title: New approaches for fibrosis regression in alcoholic cirrhosis.
abstract: Liver fibrosis is a dynamic process of fibrinogenesis and fibrinolysis. It is sequelae of recurrent injury and inflammation to the liver. Only recently has there been significant progress in understanding the pathophysiology behind liver fibrosis. This has allowed for the development of identifiable targets for potential therapies. In this article we will discuss the underlying general cellular mechanisms that play a key role in the pathway of fibrinogenesis and fibrinolysis and then focus on the mechanisms that are key in alcohol-induced liver fibrosis. Challenges in formulating potential fibrosis therapies as well as current potential targets for liver fibrosis will be reviewed as well.
authors.affiliation: Section of Digestive Diseases, Department of Veterans Affairs Connecticut Healthcare, West Haven, CT, 06516, USA. wajahat.mehal@yale.edu.|Section of Digestive Diseases, Department of Internal Medicine, Yale University, New Haven, CT, 06520, USA. wajahat.mehal@yale.edu.
authors.forename: Wajahat
authors.initials: W
authors.lastname: Mehal
authors.affiliation: Section of Digestive Diseases, Department of Internal Medicine, Yale University, New Haven, CT, 06520, USA.
authors.forename: Uyen
authors.initials: U
authors.lastname: To
mesh_terms: D000437:Alcoholism / Q000188:drug therapy / Q000276:immunology / Q000473:pathology; D000818:Animals; D002986:Clinical Trials as Topic; D019468:Disease Management; D006801:Humans; D008104:Liver Cirrhosis, Alcoholic / Q000188:drug therapy / Q000276:immunology / Q000473:pathology*; D015398:Signal Transduction
keywords: Fibrosis; Inflammatory; Liver