title: Isolation of rugosin A, B and related compounds as dipeptidyl peptidase-IV inhibitors from rose bud extract powder.
abstract: Dipeptidyl peptidase-IV (DPP-IV) is a protease responsible for the degradation of the incretin hormone. A number of DPP-IV inhibitors have been approved for use in the treatment of type 2 diabetes. While these inhibitors are effective for this treatment, methods for the prevention of this disease are also required as diabetes patient numbers are currently increasing rapidly worldwide. We screened the DPP-IV inhibitory activities of edible plant extracts with the intention of using these extracts in a functional food supplement for the prevention of diabetes. Rose (Rosa gallica) bud extract powder was a promising material with high inhibitory activity. In this study, seven ellagitannins were isolated as active compounds through activity-guided fractionations, and their DPP-IV inhibitory activities were measured. Among them, rugosin A and B showed the highest inhibitory activities and rugosin B was shown as the major contributing compound in rose bud extract powder.
authors.affiliation: a Laboratory of Food Biochemistry, Division of Applied Bioscience , Graduate School of Agriculture, Hokkaido University , Sapporo , Japan.
authors.forename: Eisuke
authors.initials: E
authors.lastname: Kato
authors.affiliation: a Laboratory of Food Biochemistry, Division of Applied Bioscience , Graduate School of Agriculture, Hokkaido University , Sapporo , Japan.
authors.forename: Yuta
authors.initials: Y
authors.lastname: Uenishi
authors.affiliation: b Q'sai Co., Ltd. , Fukuoka , Japan.
authors.forename: Yosuke
authors.initials: Y
authors.lastname: Inagaki
authors.affiliation: b Q'sai Co., Ltd. , Fukuoka , Japan.
authors.forename: Mihoko
authors.initials: M
authors.lastname: Kurokawa
authors.affiliation: a Laboratory of Food Biochemistry, Division of Applied Bioscience , Graduate School of Agriculture, Hokkaido University , Sapporo , Japan.
authors.forename: Jun
authors.initials: J
authors.lastname: Kawabata
keywords: diabetes; dipeptidyl peptidase IV; ellagitannin