title: Influence of natural and synthetic crosslinking reagents on the structural and mechanical properties of chitosan-based hybrid hydrogels.
abstract: The objective of this work was to correlate the physical and chemical properties of chitosan/poly(vinyl alcohol)/genipin (CS/PVA/GEN) and chitosan/poly(vinyl alcohol)/glutaraldehyde (CS/PVA/GA) hydrogels with their structural and mechanical responses. In addition, their molecular structures were determined and confirmed using FTIR spectroscopy. The results indicated that the hybrid hydrogels crosslinked with genipin showed similar crystallinity, thermal properties, elongation ratio and structural parameters as those crosslinked with glutaraldehyde. However, it was found that the elastic moduli of the two hybrid hydrogels were slightly different: 2.82±0.33MPa and 2.08±0.11MPa for GA and GEN, respectively. Although the hybrid hydrogels crosslinked with GEN presented a lower elastic modulus, the main advantage is that GEN is five to ten thousand times less cytotoxic than GA. This means that the structural and mechanical properties of hybrid hydrogels crosslinked with GEN can easily be tuned and could have potential applications in the tissue engineering, regenerative medicine, food, agriculture and environmental industries.
authors.affiliation: Instituto de Investigaciones en Materiales, Universidad Nacional Autónoma de México, Apdo. Postal 70-360, Cd. Universitaria, Cd. de México 04530, Mexico; Posgrado en Ciencia e Ingeniería de Materiales, Universidad Nacional Autónoma de México, Apdo, Postal 70-360, Cd. Universitaria, Cd. de México 04530, Mexico.
authors.forename: I M
authors.initials: IM
authors.lastname: Garnica-Palafox
authors.affiliation: Instituto de Investigaciones en Materiales, Universidad Nacional Autónoma de México, Apdo. Postal 70-360, Cd. Universitaria, Cd. de México 04530, Mexico. Electronic address: fsanchez@iim.unam.mx.
authors.forename: F M
authors.initials: FM
authors.lastname: Sánchez-Arévalo
mesh_terms: D001672:Biocompatible Materials / Q000737:chemistry; D001688:Biological Products / Q000737:chemistry*; D048271:Chitosan / Q000737:chemistry*; D005976:Glutaral / Q000737:chemistry; D020100:Hydrogels / Q000737:chemistry*; D039823:Iridoids / Q000737:chemistry; D055595:Mechanical Phenomena; D011142:Polyvinyl Alcohol / Q000737:chemistry; D013696:Temperature; D013718:Tensile Strength
chemical_list: D001672:Biocompatible Materials; D001688:Biological Products; D020100:Hydrogels; D039823:Iridoids; D011142:Polyvinyl Alcohol; D048271:Chitosan; C007834:genipin; D005976:Glutaral
keywords: Chitosan; Chitosan (PubChem CID: 71853); Genipin; Genipin (PubChem CID: 442424); Glutaraldehyde; Glutaraldehyde (PubChem CID: 3485); Hybrid hydrogels; Poly(vinyl alcohol); Polyvinyl alcohol (PubChem CID: 11199)