title: Antivirals for Respiratory Viral Infections: Problems and Prospects.
abstract: In the past two decades, several newly emerging and reemerging viral respiratory pathogens including several influenza viruses (avian influenza and pandemic influenza), severe acute respiratory syndrome coronavirus (SARS-CoV), and Middle East respiratory syndrome coronavirus (MERS-CoV), have continued to challenge medical and public health systems. Thereafter, the development of cost-effective, broad-spectrum antiviral agents is the urgent mission of both virologists and pharmacologists. Current antiviral developments have focused targets on viral entry, replication, release, and intercellular pathways essential for viral life cycle. Here, we review the current literature on challenges and prospects in the development of these antivirals.
authors.affiliation: The First College of Clinical Medical Science, China Three Gorges University/Yichang Central People's Hospital, Yichang, China.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Liu
authors.affiliation: The First College of Clinical Medical Science, China Three Gorges University/Yichang Central People's Hospital, Yichang, China.
authors.forename: Yuan-Hong
authors.initials: YH
authors.lastname: Zhou
authors.affiliation: The First College of Clinical Medical Science, China Three Gorges University/Yichang Central People's Hospital, Yichang, China.
authors.forename: Feng
authors.initials: F
authors.lastname: Ye
authors.affiliation: State Key Laboratory of Virology, Institute of Medical Virology, School of Medicine, Wuhan University, Wuhan, China.
authors.forename: Zhan-Qiu
authors.initials: ZQ
authors.lastname: Yang
mesh_terms: D000818:Animals; D000998:Antiviral Agents / Q000627:therapeutic use*; D018352:Coronavirus Infections / Q000188:drug therapy* / Q000821:virology*; D006801:Humans; D065207:Middle East Respiratory Syndrome Coronavirus; D012141:Respiratory Tract Infections / Q000188:drug therapy* / Q000821:virology*; D045473:Severe acute respiratory syndrome-related coronavirus; D045169:Severe Acute Respiratory Syndrome / Q000188:drug therapy / Q000821:virology
chemical_list: D000998:Antiviral Agents