title: Synthesis and Antiproliferative Activity of [RuCp(PPh3)2(HdmoPTA)](OSO2CF3)2 (HdmoPTA = 3,7-H-3,7-Dimethyl-1,3,7-triaza-5-phosphabicyclo[3.3.1]nonane).
abstract: The complex [RuCp(PPh3)2(HdmoPTA)](OSO2CF3)2 (2; HdmoPTA = 3,7-H-3,7-dimethyl-1,3,7-triaza-5-phosphabicyclo[3.3.1]nonane) was synthesized and characterized. Its crystal structure was determined by single-crystal X-ray diffraction. The complex showed a more potent antiproliferative activity than cisplatin against a representative panel of human cancer cells.
authors.affiliation: Sección de Química Inorgánica, Departamento de Química, Facultad de Ciencias, Universidad de La Laguna , C/Astrofísico Francisco Sánchez 3, La Laguna 38200, Tenerife, Spain.
authors.forename: Zenaida
authors.initials: Z
authors.lastname: Mendoza
authors.affiliation: Sección de Química Inorgánica, Departamento de Química, Facultad de Ciencias, Universidad de La Laguna , C/Astrofísico Francisco Sánchez 3, La Laguna 38200, Tenerife, Spain.
authors.forename: Pablo
authors.initials: P
authors.lastname: Lorenzo-Luis
authors.affiliation: Área de Química Inorgánica-CIESOL, Facultad de Ciencias, Universidad de Almería , Almería 04120, Spain.
authors.forename: Manuel
authors.initials: M
authors.lastname: Serrano-Ruiz
authors.affiliation: BioLab, Instituto Universitario de Bio-Orgánica "Antonio González", Centro de Investigaciones Biomédicas de Canarias, Universidad de La Laguna , C/Astrofísico Francisco Sánchez 2, La Laguna 38200, Tenerife, Spain.
authors.forename: Elva
authors.initials: E
authors.lastname: Martín-Batista
authors.affiliation: BioLab, Instituto Universitario de Bio-Orgánica "Antonio González", Centro de Investigaciones Biomédicas de Canarias, Universidad de La Laguna , C/Astrofísico Francisco Sánchez 2, La Laguna 38200, Tenerife, Spain.
authors.forename: José M
authors.initials: JM
authors.lastname: Padrón
authors.affiliation: Área de Química Inorgánica-CIESOL, Facultad de Ciencias, Universidad de Almería , Almería 04120, Spain.
authors.forename: Franco
authors.initials: F
authors.lastname: Scalambra
authors.affiliation: Área de Química Inorgánica-CIESOL, Facultad de Ciencias, Universidad de Almería , Almería 04120, Spain.
authors.forename: Antonio
authors.initials: A
authors.lastname: Romerosa
mesh_terms: D000473:Alkanes / Q000737:chemistry; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D060326:Chemistry Techniques, Synthetic; D002945:Cisplatin / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D015394:Molecular Structure; D012428:Ruthenium / Q000737:chemistry; D012995:Solubility
chemical_list: D000473:Alkanes; D000970:Antineoplastic Agents; D012428:Ruthenium; D002945:Cisplatin; C017573:nonane