title: Modulation of tumorigenesis by the pro-inflammatory microRNA miR-301a in mouse models of lung cancer and colorectal cancer.
abstract: Lung cancer and colorectal cancer account for over one-third of all cancer deaths in the United States. MicroRNA-301a (miR-301a) is an activator of both nuclear factor-κB (NF-κB) and Stat3, and is overexpressed in both deadly malignancies. In this work, we show that genetic ablation of miR-301a reduces Kras-driven lung tumorigenesis in mice. And miR-301a deficiency protects animals from dextran sodium sulfate-induced colon inflammation and colitis-associated colon carcinogenesis. We also demonstrate that miR-301a deletion in bone marrow-derived cells attenuates tumor growth in the colon carcinogenesis model. Our findings ascertain that one microRNA-miR-301a-activates two major inflammatory pathways (NF-κB and Stat3) in vivo, generating a pro-inflammatory microenvironment that facilitates tumorigenesis.
authors.affiliation: Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA; Department of Biochemistry and Molecular Biology, School of Medicine, University of Louisville, Louisville, KY, USA; Diabetes and Obesity Center, Department of Medicine, University of Louisville, Louisville, KY, USA; Institute of Pharmaceutical Research, South China Normal University, Guangzhou, China.
authors.forename: Xiaodong
authors.initials: X
authors.lastname: Ma
authors.affiliation: Department of Histology and Embryology; Southern Medical University , Guangzhou, China.
authors.forename: Fang
authors.initials: F
authors.lastname: Yan
authors.affiliation: Department of Biochemistry and Molecular Biology, School of Medicine, University of Louisville , Louisville, KY, USA.
authors.forename: Qipan
authors.initials: Q
authors.lastname: Deng
authors.affiliation: Department of Biochemistry and Molecular Biology, School of Medicine, University of Louisville , Louisville, KY, USA.
authors.forename: Fenge
authors.initials: F
authors.lastname: Li
authors.affiliation: Department of Medical Laboratory and Central Laboratory, The Central Hospital of Wuhan , Wuhan, China.
authors.forename: Zhongxin
authors.initials: Z
authors.lastname: Lu
authors.affiliation: Institute of Biochemistry and Cell Biology, Shanghai Institutes of Biological Sciences, Chinese Academy of Sciences , Shanghai, China.
authors.forename: Mofang
authors.initials: M
authors.lastname: Liu
authors.affiliation: Department of Gastroenterology, Shenzhen Municipal People's Hospital, Jinan University of Medical Sciences , Shenzhen, China.
authors.forename: Lisheng
authors.initials: L
authors.lastname: Wang
authors.affiliation: Diabetes and Obesity Center, Department of Medicine, University of Louisville , Louisville, KY, USA.
authors.forename: Daniel J
authors.initials: DJ
authors.lastname: Conklin
authors.affiliation: Diabetes and Obesity Center, Department of Medicine, University of Louisville , Louisville, KY, USA.
authors.forename: James
authors.initials: J
authors.lastname: McCracken
authors.affiliation: Diabetes and Obesity Center, Department of Medicine, University of Louisville , Louisville, KY, USA.
authors.forename: Sanjay
authors.initials: S
authors.lastname: Srivastava
authors.affiliation: Diabetes and Obesity Center, Department of Medicine, University of Louisville , Louisville, KY, USA.
authors.forename: Aruni
authors.initials: A
authors.lastname: Bhatnagar
authors.affiliation: Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA; Department of Biochemistry and Molecular Biology, School of Medicine, University of Louisville, Louisville, KY, USA; Diabetes and Obesity Center, Department of Medicine, University of Louisville, Louisville, KY, USA.
authors.forename: Yong
authors.initials: Y
authors.lastname: Li
keywords: Kras; NF-κB; Stat3; colon cancer; lung cancer; miR-301a; tumor microenvironment