title: The development of PubMed search strategies for patient preferences for treatment outcomes.
abstract: The importance of respecting patients' preferences when making treatment decisions is increasingly recognized. Efficiently retrieving papers from the scientific literature reporting on the presence and nature of such preferences can help to achieve this goal. The objective of this study was to create a search filter for PubMed to help retrieve evidence on patient preferences for treatment outcomes.
  
  
  
  A total of 27 journals were hand-searched for articles on patient preferences for treatment outcomes published in 2011. Selected articles served as a reference set. To develop optimal search strategies to retrieve this set, all articles in the reference set were randomly split into a development and a validation set. MeSH-terms and keywords retrieved using PubReMiner were tested individually and as combinations in PubMed and evaluated for retrieval performance (e.g. sensitivity (Se) and specificity (Sp)).
  
  
  
  Of 8238 articles, 22 were considered to report empirical evidence on patient preferences for specific treatment outcomes. The best search filters reached Se of 100 % [95 % CI 100-100] with Sp of 95 % [94-95 %] and Sp of 97 % [97-98 %] with 75 % Se [74-76 %]. In the validation set these queries reached values of Se of 90 % [89-91 %] with Sp 94 % [93-95 %] and Se of 80 % [79-81 %] with Sp of 97 % [96-96 %], respectively.
  
  
  
  Narrow and broad search queries were developed which can help in retrieving literature on patient preferences for treatment outcomes. Identifying such evidence may in turn enhance the incorporation of patient preferences in clinical decision making and health technology assessment.
authors.affiliation: Radboud Institute for Health Sciences, Radboud University Medical Center, Nijmegen, The Netherlands. Ralph.vanHoorn@radboudumc.nl.
authors.forename: Ralph
authors.identifier: 0000-0003-1413-1602
authors.initials: R
authors.lastname: van Hoorn
authors.affiliation: Radboud Institute for Health Sciences, Radboud University Medical Center, Nijmegen, The Netherlands.
authors.forename: Wietske
authors.initials: W
authors.lastname: Kievit
authors.affiliation: Health Economics and Decision Science (HEDS), School of Health and Related Research (ScHARR), University of Sheffield Regent Court, Sheffield, United Kingdom.
authors.forename: Andrew
authors.initials: A
authors.lastname: Booth
authors.affiliation: Department of Health Services Research, Institute for Public Health and Nursing Research (IPP), University of Bremen, Bremen, Germany.|Health Sciences Bremen, University of Bremen, Bremen, Germany.
authors.forename: Kati
authors.initials: K
authors.lastname: Mozygemba
authors.affiliation: Centre for Medical Ethics, University of Oslo, Oslo, Norway.
authors.forename: Kristin Bakke
authors.initials: KB
authors.lastname: Lysdahl
authors.affiliation: Institute of Bioethics and Medical Humanities, "A. Gemelli" School of Medicine, Università Cattolica del Sacro Cuore, Rome, Italy.
authors.forename: Pietro
authors.initials: P
authors.lastname: Refolo
authors.affiliation: Institute of Bioethics and Medical Humanities, "A. Gemelli" School of Medicine, Università Cattolica del Sacro Cuore, Rome, Italy.
authors.forename: Dario
authors.initials: D
authors.lastname: Sacchini
authors.affiliation: Department of Health Services Research, Institute for Public Health and Nursing Research (IPP), University of Bremen, Bremen, Germany.|Health Sciences Bremen, University of Bremen, Bremen, Germany.
authors.forename: Ansgar
authors.initials: A
authors.lastname: Gerhardus
authors.affiliation: Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, The Netherlands.
authors.forename: Gert Jan
authors.initials: GJ
authors.lastname: van der Wilt
authors.affiliation: Radboud Institute for Health Sciences, Radboud University Medical Center, Nijmegen, The Netherlands.
authors.forename: Marcia
authors.initials: M
authors.lastname: Tummers
mesh_terms: D006801:Humans; D057240:Patient Preference; D039781:PubMed; D016896:Treatment Outcome
keywords: Evidence-based medicine*; Information storage and retrieval/methods*; MEDLINE; Patient preferences; Treatment outcome