title: Serum Liver Fibrosis Markers in the Prognosis of Liver Cirrhosis: A Prospective Observational Study.
abstract: BACKGROUND The prognostic role of serum liver fibrosis markers in cirrhotic patients remains unclear. We performed a prospective observational study to evaluate the effect of amino-terminal pro-peptide of type III pro-collagen (PIIINP), collagen IV (CIV), laminin (LN), and hyaluronic acid (HA) on the prognosis of liver cirrhosis. MATERIAL AND METHODS All patients who were diagnosed with liver cirrhosis and admitted to our department were prospectively enrolled. PIIINP, CIV, LN, and HA levels were tested. RESULTS Overall, 108 cirrhotic patients were included. Correlation analysis demonstrated that CIV (coefficient r: 0.658, p<0.001; coefficient r: 0.368, p<0.001), LN (coefficient r: 0.450, p<0.001; coefficient r: 0.343, p<0.001), and HA (coefficient r: 0.325, p=0.001; coefficient r: 0.282, p=0.004) levels, but not PIIINP level (coefficient r: 0.081, p=0.414; coefficient r: 0.090, p=0.363), significantly correlated with Child-Pugh and MELD scores. Logistic regression analysis demonstrated that HA (odds ratio=1.00003, 95% confidence interval [CI]=1.000004-1.000056, p=0.022) was significantly associated with the 6-month mortality. Receiver operating characteristics analysis demonstrated that the area under the curve (AUC) of HA for predicting the 6-month mortality was 0.612 (95%CI=0.508-0.709, p=0.1531). CONCLUSIONS CIV, LN, and HA levels were significantly associated with the severity of liver dysfunction, but might be inappropriate for the prognostic assessment of liver cirrhosis.
authors.affiliation: Liver Cirrhosis Group, Department of Gastroenterology, General Hospital of Shenyang Military Area, Shenyang, Liaoning, China (mainland).
authors.forename: Xingshun
authors.initials: X
authors.lastname: Qi
authors.affiliation: Liver Cirrhosis Group, Department of Gastroenterology, General Hospital of Shenyang Military Area, Shenyang, Liaoning, China (mainland).
authors.forename: Xu
authors.initials: X
authors.lastname: Liu
authors.affiliation: Liver Cirrhosis Group, Department of Gastroenterology, General Hospital of Shenyang Military Area, Shenyang, Liaoning, China (mainland).
authors.forename: Yongguo
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Liver Cirrhosis Group, Department of Gastroenterology, General Hospital of Shenyang Military Area, Shenyang, Liaoning, China (mainland).
authors.forename: Yue
authors.initials: Y
authors.lastname: Hou
authors.affiliation: Liver Cirrhosis Group, Department of Gastroenterology, General Hospital of Shenyang Military Area, Shenyang, Liaoning, China (mainland).
authors.forename: Linan
authors.initials: L
authors.lastname: Ren
authors.affiliation: Liver Cirrhosis Group, Department of Gastroenterology, General Hospital of Shenyang Military Area, Shenyang, Liaoning, China (mainland).
authors.forename: Chunyan
authors.initials: C
authors.lastname: Wu
authors.affiliation: Liver Cirrhosis Group, Department of Gastroenterology, General Hospital of Shenyang Military Area, Shenyang, Liaoning, China (mainland).
authors.forename: Jiang
authors.initials: J
authors.lastname: Chen
authors.affiliation: Liver Cirrhosis Group, Department of Gastroenterology, General Hospital of Shenyang Military Area, Shenyang, Liaoning, China (mainland).
authors.forename: Chunlian
authors.initials: C
authors.lastname: Xia
authors.affiliation: Liver Cirrhosis Group, Department of Gastroenterology, General Hospital of Shenyang Military Area, Shenyang, Liaoning, China (mainland).
authors.forename: Jiajun
authors.initials: J
authors.lastname: Zhao
authors.affiliation: Liver Cirrhosis Group, Department of Gastroenterology, General Hospital of Shenyang Military Area, Shenyang, Liaoning, China (mainland).
authors.forename: Di
authors.initials: D
authors.lastname: Wang
authors.affiliation: Liver Cirrhosis Group, Department of Gastroenterology, General Hospital of Shenyang Military Area, Shenyang, Liaoning, China (mainland).
authors.forename: Yanlin
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Liver Cirrhosis Group, Department of Gastroenterology, General Hospital of Shenyang Military Area, Shenyang, Liaoning, China (mainland).
authors.forename: Xia
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Liver Cirrhosis Group, Department of Gastroenterology, General Hospital of Shenyang Military Area, Shenyang, Liaoning, China (mainland).
authors.forename: Hao
authors.initials: H
authors.lastname: Lin
authors.affiliation: Liver Cirrhosis Group, Department of Gastroenterology, General Hospital of Shenyang Military Area, Shenyang, Liaoning, China (mainland).
authors.forename: Hezhi
authors.initials: H
authors.lastname: Wang
authors.affiliation: Liver Cirrhosis Group, Department of Gastroenterology, General Hospital of Shenyang Military Area, Shenyang, Liaoning, China (mainland).
authors.forename: Jinling
authors.initials: J
authors.lastname: Wang
authors.affiliation: Liver Cirrhosis Group, Department of Gastroenterology, General Hospital of Shenyang Military Area, Shenyang, Liaoning, China (mainland).
authors.forename: Zhongmin
authors.initials: Z
authors.lastname: Cui
authors.affiliation: Liver Cirrhosis Group, Department of Gastroenterology, General Hospital of Shenyang Military Area, Shenyang, Liaoning, China (mainland).
authors.forename: Xueyan
authors.initials: X
authors.lastname: Li
authors.affiliation: Liver Cirrhosis Group, Department of Gastroenterology, General Hospital of Shenyang Military Area, Shenyang, Liaoning, China (mainland).
authors.forename: Han
authors.initials: H
authors.lastname: Deng
authors.affiliation: Liver Cirrhosis Group, Department of Gastroenterology, General Hospital of Shenyang Military Area, Shenyang, Liaoning, China (mainland).
authors.forename: Feifei
authors.initials: F
authors.lastname: Hou
authors.affiliation: Liver Cirrhosis Group, Department of Gastroenterology, General Hospital of Shenyang Military Area, Shenyang, Liaoning, China (mainland).
authors.forename: Ying
authors.initials: Y
authors.lastname: Peng
authors.affiliation: Liver Cirrhosis Group, Department of Gastroenterology, General Hospital of Shenyang Military Area, Shenyang, Liaoning, China (mainland).
authors.forename: Xueying
authors.initials: X
authors.lastname: Wang
authors.affiliation: Liver Cirrhosis Group, Department of Gastroenterology, General Hospital of Shenyang Military Area, Shenyang, Liaoning, China (mainland).
authors.forename: Xiaodong
authors.initials: X
authors.lastname: Shao
authors.affiliation: Liver Cirrhosis Group, Department of Gastroenterology, General Hospital of Shenyang Military Area, Shenyang, Liaoning, China (mainland).
authors.forename: Hongyu
authors.initials: H
authors.lastname: Li
authors.affiliation: Liver Cirrhosis Group, Department of Gastroenterology, General Hospital of Shenyang Military Area, Shenyang, Liaoning, China (mainland).
authors.forename: Xiaozhong
authors.initials: X
authors.lastname: Guo
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood; D024141:Collagen Type IV / Q000097:blood; D005260:Female; D019694:Hepatitis B, Chronic / Q000097:blood / Q000473:pathology; D006801:Humans; D006820:Hyaluronic Acid / Q000097:blood; D007797:Laminin / Q000097:blood; D008103:Liver Cirrhosis / Q000097:blood* / Q000473:pathology / Q000821:virology; D008297:Male; D008875:Middle Aged; D010446:Peptide Fragments / Q000097:blood; D011347:Procollagen / Q000097:blood; D011379:Prognosis; D011446:Prospective Studies; D012372:ROC Curve
chemical_list: D015415:Biomarkers; D024141:Collagen Type IV; D007797:Laminin; D010446:Peptide Fragments; D011347:Procollagen; C041876:procollagen Type III-N-terminal peptide; D006820:Hyaluronic Acid