title: Update on immunopathogenesis and immunotherapy in multiple sclerosis.
abstract: Multiple sclerosis is a chronic inflammatory demyelinating disease of the central nervous system. Both genetic and environmental factors are believed to contribute to the pathogenesis of the disease. Histopathological findings suggest that multiple sclerosis is an immune-mediated disease, involving both the cellular and humoral immune systems. Within the last 20 years, several disease-modifying therapies for the treatment of multiple sclerosis were established. Moreover, promising new substances are currently being tested in clinical trials and will likely broaden the therapeutic opportunities available within the upcoming years.
authors.affiliation: Department of Neurology, Klinikum Rechts der Isar, Technische Universität München, Munich, Germany.
authors.forename: Rebecca C
authors.initials: RC
authors.lastname: Selter
authors.affiliation: Department of Neurology, Klinikum Rechts der Isar, Technische Universität München, Munich, Germany; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany; Competence Network on Multiple Sklerosis, Munich, Germany.
authors.forename: Bernhard
authors.initials: B
authors.lastname: Hemmer
keywords: disease-modifying therapy; immunopathogenesis; multiple sclerosis