title: Reducing prostaglandin E2 production to raise cancer immunogenicity.
abstract: Cyclooxygenases (COX), commonly upregulated in numerous cancers, generate prostaglandin E2 (PGE2), which has been implicated in key aspects of malignant growth including proliferation, invasion and angiogenesis. Recently, we showed that production of PGE2 by cancer cells dominantly enables progressive tumor growth via immune escape and that cyclooxygenase inhibitors synergize with immunotherapy to enhance tumor eradication.
authors.affiliation: Cancer Inflammation and Immunity Group, Cancer Research UK Manchester Institute, The University of Manchester , Manchester, UK.
authors.forename: Santiago
authors.initials: S
authors.lastname: Zelenay
authors.affiliation: Immunobiology Laboratory, The Francis Crick Institute, Lincoln's Inn Fields Laboratory , 44 Lincoln's Inn Fields , London, UK.
authors.forename: Caetano
authors.initials: C
authors.lastname: Reis e Sousa
keywords: COX-2; Cancer inflammation; cancer immune evasion; cancer immunity; dendritic cells; immunotherapy