title: Macular Ganglion Cell Imaging Study: Covariate Effects on the Spectral Domain Optical Coherence Tomography for Glaucoma Diagnosis.
abstract: OBJECTIVE
  To evaluate the effect of multiple covariates on the diagnostic performance of the Cirrus high-definition optical coherence tomography (HD-OCT) for glaucoma detection.
  
  
  METHODS
  A prospective case-control study was performed and included 173 recently diagnosed glaucoma patients and 63 unaffected individuals from the Macular Ganglion Cell Imaging Study. Regression analysis of receiver operating characteristic were conducted to evaluate the influence of age, spherical equivalent, axial length, optic disc size, and visual field index on the macular ganglion cell-inner plexiform layer (GCIPL) and peripapillary retinal nerve fiber layer (RNFL) measurements.
  
  
  RESULTS
  Disease severity, as measured by visual field index, had a significant effect on the diagnostic performance of all Cirrus HD-OCT parameters. Age, axial length and optic disc size were significantly associated with diagnostic accuracy of average peripapillary RNFL thickness, whereas axial length had a significant effect on the diagnostic accuracy of average GCIPL thickness.
  
  
  CONCLUSIONS
  Diagnostic performance of the Cirrus HD-OCT may be more accurate in the advanced stages of glaucoma than at earlier stages. A smaller optic disc size was significantly associated with improved the diagnostic ability of average RNFL thickness measurements; however, GCIPL thickness may be less affected by age and optic disc size.
authors.affiliation: Departement of Ophthalmology, Konyang University Hospital, Daejeon, Korea.|Chung-Ang University Graduate School, Seoul, Korea.
authors.forename: Jae Hoon
authors.initials: JH
authors.lastname: Jeong
authors.affiliation: Department of Ophthalmology, Seoul National University Hospital, Seoul, Korea.|Department of Ophthalmology, Seoul National University College of Medicine, Seoul, Korea.
authors.forename: Yun Jeong
authors.initials: YJ
authors.lastname: Choi
authors.affiliation: Department of Ophthalmology, Seoul National University Hospital, Seoul, Korea.|Department of Ophthalmology, Seoul National University College of Medicine, Seoul, Korea.
authors.forename: Ki Ho
authors.initials: KH
authors.lastname: Park
authors.affiliation: Department of Ophthalmology, Seoul National University Hospital, Seoul, Korea.|Department of Ophthalmology, Seoul National University College of Medicine, Seoul, Korea.
authors.forename: Dong Myung
authors.initials: DM
authors.lastname: Kim
authors.affiliation: Department of Ophthalmology, Seoul National University Hospital, Seoul, Korea.|Department of Ophthalmology, Seoul National University College of Medicine, Seoul, Korea.
authors.forename: Jin Wook
authors.identifier: http://orcid.org/0000-0001-7311-7080
authors.initials: JW
authors.lastname: Jeoung
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D005901:Glaucoma / Q000000981:diagnostic imaging*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009898:Optic Disk / Q000473:pathology*; D012165:Retinal Ganglion Cells / Q000473:pathology*; D041623:Tomography, Optical Coherence