title: [Novel approaches to control the rise in pertussis cases].
abstract: Pertussis is a respiratory disease caused by the Gram-negative encapsulated bacterium Bordetella pertussis. Despite the high vaccination coverage rate and addition of new booster doses to the immunisation scheme (in response to the epidemiological situation), pertussis is on the rise not only in the Czech Republic but also in many other countries. The age groups at highest risk are infants and, to a lower extent, newborns who can get infected before receiving the first dose of vaccine and develop a severe course of the disease, often requiring admission to hospital. The most common source of infection are adults or adolescents from the childs close environment who experience a mild course of the disease because of the previous vaccination. The immune response induced by the currently available acellular vaccines does not last. It can be reasonably assumed that pertussis has been underreported. Multiple studies have shown mutations in the causative bacterium that confer higher pathogenicity to it, either as a result of enhanced production of pertussis toxin or loss of some antigens. Possible strategies to control these negative trends are to develop novel more effective vaccines using new adjuvants or to use whole-cell vaccines. Maternal vaccination in pregnancy trimester 3 also turned out to be effective.
  
  
  BACKGROUND
  pertussis - vaccination - epidemiology - diagnosis - newborns.
authors.forename: J
authors.initials: J
authors.lastname: Machač
authors.forename: R
authors.initials: R
authors.lastname: Chlíbek
authors.forename: S
authors.initials: S
authors.lastname: Plíšek
mesh_terms: D000293:Adolescent; D000328:Adult; D001886:Bordetella pertussis; D002648:Child; D002675:Child, Preschool; D018153:Czech Republic; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D010567:Pertussis Vaccine; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000453:epidemiology / Q000276:immunology / Q000517:prevention & control; D014611:Vaccination; D014917:Whooping Cough / Q000453:epidemiology / Q000276:immunology / Q000517:prevention & control; D055815:Young Adult
chemical_list: D010567:Pertussis Vaccine