title: Pregabalin use disorder and secondary nicotine dependence in a woman with no substance abuse history.
abstract: This is an addictovigilance report of a pregabalin use disorder case in a young female patient who secondarily presented a tobacco use disorder after smoking initiation combined with pregabalin intake. Pregabalin was first prescribed for anxiety. Concomitant use of pregabalin with tobacco led to a synergic effect of both substances. She presented a craving behavior for pregabalin, with a tolerance phenomenon and a withdrawal syndrome between pregabaline intakes. The patient had a history of depressive disorder, personality disorder and anorexia, but never had any history of substance use disorder. This case report is noteworthy for 3 reasons: 1: this is one of the first report of pregabalin use disorder in a patient without any substance abuse disorder (licit or illicit), with the exception of a personal vulnerability factors to substance abuse; 2: the patient presented characteristics of pregabalin use disorder at usual dose (below 300mg per day), with drug-seeking behavior, tolerance phenomenon and intense craving with these moderate doses; 3: concomitant use of pregabalin with tobacco led to a synergic effect of both substances.
authors.affiliation: Université Paul-Sabatier, faculté de médecine de Toulouse, département universitaire de médecine générale de Toulouse, 133, route de Narbonne, 31062 Toulouse, France. Electronic address: damien.driot@dumg-toulouse.fr.
authors.forename: Damien
authors.initials: D
authors.lastname: Driot
authors.affiliation: Université Paul-Sabatier, faculté de médecine de Toulouse, département universitaire de médecine générale de Toulouse, 133, route de Narbonne, 31062 Toulouse, France.
authors.forename: Bruno
authors.initials: B
authors.lastname: Chicoulaa
authors.affiliation: Centre Midi-Pyrénées d'evaluation et d'information sur la pharmacodépendance et d'addictovigilance (CEIP-A), 31000 Toulouse, France.
authors.forename: Emilie
authors.initials: E
authors.lastname: Jouanjus
authors.affiliation: Université Paul-Sabatier, faculté de médecine de Toulouse, département universitaire de médecine générale de Toulouse, 133, route de Narbonne, 31062 Toulouse, France.
authors.forename: Julie
authors.initials: J
authors.lastname: Dupouy
authors.affiliation: Université Paul-Sabatier, faculté de médecine de Toulouse, département universitaire de médecine générale de Toulouse, 133, route de Narbonne, 31062 Toulouse, France.
authors.forename: Stéphane
authors.initials: S
authors.lastname: Oustric
authors.affiliation: Centre Midi-Pyrénées d'evaluation et d'information sur la pharmacodépendance et d'addictovigilance (CEIP-A), 31000 Toulouse, France.
authors.forename: Maryse
authors.initials: M
authors.lastname: Lapeyre-Mestre
keywords: Addictovigilance; Case reports; Pregabalin; Prégabaline; Présentation de cas; Substance-related disorders; Tobacco use; Troubles liés à une substance; Usage de tabac