title: Acute Cardiotoxicity After Daunorubicin in Acute Myeloid Leukaemia.
abstract: Use of the anthracycline antibiotics daunorubicin and adriamycin as antineoplastic agents is limited by dose-dependent, late cardiac toxicity. We describe a patient who developed fatal cardiogenic shock after comparatively low dose daunorubicin early in the treatment of acute myeloid leukaemia (A.M.L.). She was young with no previous cardiac history: investigations for an infectious aetiology were negative and at post-mortem there was no evidence of leukaemic infiltration. This unusual case demonstrates that standard doses of daunorubicin in A.M.L. may be followed early in the treatment by severe cardiac damage.
authors.affiliation: a Departments of Haematology Western Infirmary, Western Infirmary, Dumbarton Road, Glasgow, Scotland, UK.
authors.forename: T L
authors.initials: TL
authors.lastname: Holyoake
authors.affiliation: b Departments of Pathology, Western Infirmary, Dumbarton Road, Glasgow, Scotland, UK.
authors.forename: K J
authors.initials: KJ
authors.lastname: Hillan
authors.affiliation: a Departments of Haematology Western Infirmary, Western Infirmary, Dumbarton Road, Glasgow, Scotland, UK.
authors.forename: N P
authors.initials: NP
authors.lastname: Lucie
keywords: Anthracyclines; cardiac toxicity; daunorubicin