title: Controlled release of diclofenac sodium in glycolipid incorporated micro emulsions.
abstract: The effect of the glycolipid, hexadecyl-β-d-glucopyranoside, incorporated in microemulsions (ME(1)) towards the enhancement of skin absorption and skin permeation of Diclofenac sodium (DS(2)) was evaluated. A Franz diffusion cell with a piece of pig's ear epidermis indicated that the optimized ME formulation with glycolipid (0.05wt%) exhibited significantly higher permeability than the conventional formulations. The releasing profiles of DS from ME formulations exhibited first order release kinetics resembling a diffusion controlled release model for the first 8h. Incorporating hexadecyl-β-D glucopyranoside in ME formulations shows significant potential as a delivery vehicle in the cosmetics and pharmaceutical industry.
authors.affiliation: Postgraduate Institute of Science, University of Peradeniya, Peradeniya, Sri Lanka. Electronic address: pubudupremarathne@gmail.com.
authors.forename: E P N
authors.initials: EP
authors.lastname: Premarathne
authors.affiliation: Postgraduate Institute of Science, University of Peradeniya, Peradeniya, Sri Lanka; Department of Chemistry, Faculty of Science, University of Peradeniya, Peradeniya, Sri Lanka. Electronic address: nedrak@pdn.ac.lk.
authors.forename: D N
authors.initials: DN
authors.lastname: Karunaratne
authors.affiliation: Postgraduate Institute of Science, University of Peradeniya, Peradeniya, Sri Lanka; Department of Chemistry, Faculty of Science, University of Peradeniya, Peradeniya, Sri Lanka. Electronic address: chandanip@pdn.ac.lk.
authors.forename: A D L Chandani
authors.initials: AD
authors.lastname: Perera
mesh_terms: D000818:Animals; D003692:Delayed-Action Preparations / Q000008:administration & dosage / Q000737:chemistry / Q000378:metabolism; D004008:Diclofenac / Q000008:administration & dosage / Q000737:chemistry / Q000378:metabolism*; D016503:Drug Delivery Systems / Q000379:methods*; D065546:Drug Liberation; D004655:Emulsions / Q000008:administration & dosage / Q000737:chemistry / Q000378:metabolism*; D004817:Epidermis / Q000187:drug effects / Q000378:metabolism*; D006017:Glycolipids / Q000008:administration & dosage / Q000737:chemistry / Q000378:metabolism*; D009924:Organ Culture Techniques; D012869:Skin Absorption / Q000187:drug effects / Q000502:physiology; D013552:Swine
chemical_list: D003692:Delayed-Action Preparations; D004655:Emulsions; D006017:Glycolipids; D004008:Diclofenac
keywords: Citric acid (PubChem CID: 311); Controlled release; Diclofenac sodium (DS) (PubChem CID: 5018304); Diffusion cell; Disodium phosphate (PubChem CID: 24203); Drug delivery; Glycolipid; Microemulsion; Potassium chloride (PubChem CID: 4873); Potassium dihydrogen phosphate (PubChem CID: 516951); Release kinetics; Skin absorption; Skin permeation; Sodium chloride (PubChem CID: 5234); Sorbitan monooleate (PubChem CID: 9920342)