title: Treatment of Aggressive Prolactin-Secreting Pituitary Adenomas with Adjuvant Temozolomide Chemotherapy: A Review.
abstract: Most prolactin-secreting pituitary adenomas demonstrate slow growth and are effectively managed with medical/surgical therapy. Rarely, these tumors can behave aggressively with rapid growth and invasion of local tissues, and are refractory to medical, surgical, or radio-surgical therapies. We report a case of a prolactin-secreting adenoma in a young woman, which became progressively aggressive and refractory to usual treatment modalities, but responded to treatment with the chemotherapeutic agent temozolomide. In addition, we review the literature for treatment of refractory adenomas with temozolomide. The clinical and pathologic characteristics of aggressive prolactin-secreting adenomas are reviewed, as well as their response to dopamine agonists, surgery, radiotherapy, and chemotherapy.
authors.affiliation: Seattle Science Foundation ; Neurological Surgery, Wayne State University.
authors.forename: Marc
authors.initials: M
authors.lastname: Moisi
authors.affiliation: Neurological Surgery, University of Louisville ; Neurological Surgery, University of California, Irvine ; Neurological Surgery, Swedish Neuroscience Institute.
authors.forename: Aurora S
authors.initials: AS
authors.lastname: Cruz
authors.affiliation: Neuro-oncology, Swedish Neuroscience Institute.
authors.forename: Tara
authors.initials: T
authors.lastname: Benkers
authors.affiliation: Pathology, CellNetix.
authors.forename: Steven
authors.initials: S
authors.lastname: Rostad
authors.affiliation: Endocrinology, Swedish Neuroscience Institute.
authors.forename: Frances Broyles
authors.initials: FB
authors.lastname: Broyles
authors.affiliation: Swedish Pituitary Center, Swedish Neuroscience Institute.
authors.forename: Kevin
authors.initials: K
authors.lastname: Yuen
authors.affiliation: Swedish Neuroscience Institute.
authors.forename: Marc
authors.initials: M
authors.lastname: Mayberg
keywords: aggressive pituitary tumor; prolactinoma; radiosurgery; temozolomide