title: C-reactive protein, platelets, and patent ductus arteriosus.
abstract: The association between inflammation, platelets, and patent ductus arteriosus (PDA) has not been studied so far. The purpose of this study was to evaluate whether C-reactive protein (CRP) is related to low platelet count and PDA. This was a retrospective study of 88 infants with a birth weight ≤1500 g and a gestational age ≤30 weeks. Platelet count, CRP, and an echocardiogram were assessed in all infants. The subjects were matched by sex, gestational age, and birth weight. Differences were compared using the χ2, t-test, or Mann-Whitney U-test, as appropriate. Significant variables were entered into a logistic regression model. The association between CRP and platelets was evaluated by correlation and regression analysis. Platelet count (167 000 vs. 213 000 µl-1, p = 0.015) was lower and the CRP (0.45 vs. 0.20 mg/dl, p = 0.002) was higher, and the platelet count correlated inversely with CRP (r = -0.145, p = 0.049) in the infants with vs. without PDA. Only CRP was independently associated with PDA in a logistic regression model (OR 64.1, 95% confidence interval 1.4-2941, p = 0.033).
authors.affiliation: a Department of Pediatrics and Neonatology , Instituto Universitario de Ciencias Biomédicas de Córdoba (IUCBC) , Córdoba , Argentina.
authors.forename: Leonardo
authors.initials: L
authors.lastname: Meinarde
authors.affiliation: a Department of Pediatrics and Neonatology , Instituto Universitario de Ciencias Biomédicas de Córdoba (IUCBC) , Córdoba , Argentina.
authors.forename: Macarena
authors.initials: M
authors.lastname: Hillman
authors.affiliation: a Department of Pediatrics and Neonatology , Instituto Universitario de Ciencias Biomédicas de Córdoba (IUCBC) , Córdoba , Argentina.
authors.forename: Alina
authors.initials: A
authors.lastname: Rizzotti
authors.affiliation: b Hematology and Oncology , Instituto Universitario de Ciencias Biomédicas de Córdoba (IUCBC) , Córdoba , Argentina.
authors.forename: Ana Lisa
authors.initials: AL
authors.lastname: Basquiera
authors.affiliation: c Vascular Medicine and Thrombosis , Hospital Privado, Instituto Universitario de Ciencias Biomédicas de Córdoba (IUCBC) , Córdoba , Argentina.
authors.forename: Aldo
authors.initials: A
authors.lastname: Tabares
authors.affiliation: a Department of Pediatrics and Neonatology , Instituto Universitario de Ciencias Biomédicas de Córdoba (IUCBC) , Córdoba , Argentina.|d Instituto de Investigaciones en Ciencias de la Salud, Universidad Nacional de Córdoba, Consejo Nacional de Investigaciones Científicas y Técnicas (INICSA-UNC-CONICET) , Córdoba , Argentina.
authors.forename: Eduardo
authors.initials: E
authors.lastname: Cuestas
mesh_terms: D001792:Blood Platelets; D002097:C-Reactive Protein; D004374:Ductus Arteriosus, Patent / Q000097:blood* / Q000175:diagnosis; D004452:Echocardiography; D005260:Female; D006801:Humans; D007230:Infant, Low Birth Weight; D007231:Infant, Newborn; D007234:Infant, Premature; D008297:Male; D010976:Platelet Count; D012189:Retrospective Studies
chemical_list: D002097:C-Reactive Protein
keywords: C-reactive protein; patent ductus arteriosus; platelets