title: Induction Chemotherapy Followed by Concurrent Chemoradiation in the Management of Different Stages of Cervical Carcinoma: 5-year Retrospective Study.
abstract: OBJECTIVE
  The data of survival for Indian cervical cancer patients treated by indigenous modifications of the protocol are scarce. The objective of this retrospective study was to analyze the efficacy and tolerability in patients of cervical carcinoma treated by neoadjuvant chemotherapy followed by concurrent chemoradiation.
  
  
  METHODS
  Three hundred and thirty two cases of squamous cell carcinoma of cervix who received 3 cycles of neoadjuvant chemotherapy followed concurrent chemoradiation were retrospectively analyzed for overall survival (OS), disease-free survival (DFS), and local pelvic control rate.
  
  
  RESULTS
  The 3-year OS and DFS were 93.7 % for stage I-B, 88.0 and 84.0 % for stage II-A, 82.8 and 79.7 % for stage II-B, 70.0 and 64.9 % for stage III-A, 59.3 and 52.4 % for stage III-B, and 53.6 and 32.1 % for stage IV-A disease. The 5-year OS and DFS rates were 93.7 and 87.5 % for stage I-B, 84.0 % for Stage II-A, 79.7 and 76.6 % for stage II-B, 67.6 and 59.5 % for stage III-A, 48.4 and 41.9 % for stage III-B, and 28.6 and 14.3 % for stage IV-A disease.
  
  
  CONCLUSIONS
  Neoadjuvant chemotherapy followed by concurrent chemoradiation is feasible and produces impressive disease-free and overall survival. This protocol is especially helpful for busy cancer centers with long waiting lists on radiotherapy machines.
authors.affiliation: Department of Radiation Oncology, Acharya Tulsi Regional Cancer Treatment & Research Institute, Bikaner, Rajasthan India.
authors.forename: Kamlesh Kumar
authors.initials: KK
authors.lastname: Harsh
authors.affiliation: Department of Radiation Oncology, Acharya Tulsi Regional Cancer Treatment & Research Institute, Bikaner, Rajasthan India ; Room No. 73, PG Boys Hostel, PBM Hospital Campus, Bikaner, 334003 Rajasthan India.
authors.forename: Akhil
authors.identifier: 0000-0001-6006-2631
authors.initials: A
authors.lastname: Kapoor
authors.affiliation: Department of Radiation Oncology, Acharya Tulsi Regional Cancer Treatment & Research Institute, Bikaner, Rajasthan India.
authors.forename: Murali
authors.initials: M
authors.lastname: Paramanandhan
authors.affiliation: Department of Radiation Oncology, Acharya Tulsi Regional Cancer Treatment & Research Institute, Bikaner, Rajasthan India.
authors.forename: Satya
authors.initials: S
authors.lastname: Narayan
authors.affiliation: Department of Radiation Oncology, Acharya Tulsi Regional Cancer Treatment & Research Institute, Bikaner, Rajasthan India.
authors.forename: Ramesh
authors.initials: R
authors.lastname: Purohit
authors.affiliation: Department of Radiation Oncology, Acharya Tulsi Regional Cancer Treatment & Research Institute, Bikaner, Rajasthan India.
authors.forename: Pramila
authors.initials: P
authors.lastname: Kumari
authors.affiliation: Department of Radiation Oncology, Acharya Tulsi Regional Cancer Treatment & Research Institute, Bikaner, Rajasthan India.
authors.forename: Mukesh Kumar
authors.initials: MK
authors.lastname: Singhal
keywords: Cervical carcinoma; Concurrent chemoradiation; Neoadjuvant chemotherapy; Squamous cell carcinoma