title: Primary Soft Tissue Lymphomas: Description of Seven Cases and Review of the Literature.
abstract: The present study describes a series of primary soft tissue lymphomas, including immunohistochemical characterization by tissue microarray and cytogenetic profiling. Formalin-fixed, paraffin-embedded tissue samples were collected from patients who underwent soft tissue biopsy. Cases were selected according to the definition of primary soft tissue lymphoma as a lymphoid malignancy arising in soft tissues without evidence of other nodal or extranodal localization for a period of at least 6 months. Our series comprised seven patients with a mean age of 72 years. There were three diffuse large B-cell lymphomas (DLBCLs); one B-cell lymphoma, unclassifiable, with features intermediate between DLBCL and Burkitt lymphoma; one DLBCL derived from follicular lymphoma; one ALK-negative anaplastic large cell lymphoma; and one follicular lymphoma. Immunohistochemical and molecular profiles were consistent with the histological diagnoses. The present study contributes to our knowledge about uncommon presentation of lymphoid neoplasms and confirms previously published clinical-pathological data. We present, for the first time, the complete immunohistochemical profile and molecular cytogenetic studies of these lymphoid neoplasms. A rare case of a primary soft tissue ALK-negative anaplastic large cell lymphoma is described in detail.
authors.affiliation: Division of Pathology, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, via F. Sforza, 35, 20122, Milan, Italy.
authors.forename: Alessandro
authors.initials: A
authors.lastname: Del Gobbo
authors.affiliation: Division of Pathology, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, via F. Sforza, 35, 20122, Milan, Italy.
authors.forename: Stefano
authors.initials: S
authors.lastname: Fiori
authors.affiliation: Division of Pathology, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, via F. Sforza, 35, 20122, Milan, Italy.
authors.forename: Giulia
authors.initials: G
authors.lastname: Ercoli
authors.affiliation: Division of Pathology, Istituto Ortopedico "G. Pini", p.zza Cardinale A. Ferrari 1, 20122, Milan, Italy.
authors.forename: Andrea
authors.initials: A
authors.lastname: Di Bernardo
authors.affiliation: Division of Pathology, Istituto Ortopedico "G. Pini", p.zza Cardinale A. Ferrari 1, 20122, Milan, Italy.
authors.forename: Antonina
authors.initials: A
authors.lastname: Parafioriti
authors.affiliation: Hematology Unit, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, via F. Sforza, 35, 20122, Milan, Italy.
authors.forename: Sonia
authors.initials: S
authors.lastname: Fabris
authors.affiliation: Hematology Unit, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, via F. Sforza, 35, 20122, Milan, Italy.
authors.forename: Alessandra
authors.initials: A
authors.lastname: Iurlo
authors.affiliation: Hematology Unit, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, via F. Sforza, 35, 20122, Milan, Italy.|Department of Clinical Sciences and Community Health, University of Milan, via F. Sforza, 35, 20122, Milan, Italy.
authors.forename: Antonino
authors.initials: A
authors.lastname: Neri
authors.affiliation: Division of Pathology, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, via F. Sforza, 35, 20122, Milan, Italy.|Department of Pathophysiology and Transplantation, University of Milan Medical School, Fondazione IRCCS Ca' Granda - Ospedale Maggiore Policlinico, via F. Sforza, 35, 20122, Milan, Italy.
authors.forename: Silvano
authors.initials: S
authors.lastname: Bosari
authors.affiliation: Division of Pathology, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, via F. Sforza, 35, 20122, Milan, Italy. umberto.gianelli@unimi.it.|Department of Pathophysiology and Transplantation, University of Milan Medical School, Fondazione IRCCS Ca' Granda - Ospedale Maggiore Policlinico, via F. Sforza, 35, 20122, Milan, Italy. umberto.gianelli@unimi.it.
authors.forename: Umberto
authors.initials: U
authors.lastname: Gianelli
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000077548:Anaplastic Lymphoma Kinase; D002051:Burkitt Lymphoma / Q000378:metabolism / Q000473:pathology*; D005260:Female; D006801:Humans; D016403:Lymphoma, Large B-Cell, Diffuse / Q000378:metabolism / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D020794:Receptor Protein-Tyrosine Kinases / Q000378:metabolism; D012983:Soft Tissue Neoplasms / Q000378:metabolism / Q000473:pathology*
chemical_list: C000626173:ALK protein, human; D000077548:Anaplastic Lymphoma Kinase; D020794:Receptor Protein-Tyrosine Kinases
keywords: C-myc oncogene; FISH; Lymphoma; Soft tissue tumors