title: Evaluation of Brain Redox Status and Its Association with Cognitive Dysfunction in Diabetic Animal Models by Redox Molecular Imaging (ReMI).
abstract: Oxidative stress contributes to the development of diabetic complications. Increasing epidemiologic evidence suggests that diabetes mellitus is associated with dementia and cognitive decline. However, the underlying mechanisms are not fully understood. We have evaluated brain redox status and its association of cognitive dysfunction in diabetic animal models by dynamic nuclear polarization-magnetic resonance imaging (DNP-MRI) and other oxidative stress markers. In this review, we discuss the role of oxidative stress in the development of diabetes-related dementia and clinical regulation of the redox state in new approaches to augmenting diabetes-related dementia.
authors.affiliation: Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University.
authors.forename: Noriyuki
authors.initials: N
authors.lastname: Sonoda
authors.forename: Toyoshi
authors.initials: T
authors.lastname: Inoguchi
authors.forename: Yohei
authors.initials: Y
authors.lastname: Minami
authors.forename: Fuminori
authors.initials: F
authors.lastname: Hyodo
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Ichikawa
authors.forename: Mayumi
authors.initials: M
authors.lastname: Yamato
authors.forename: Hideo
authors.initials: H
authors.lastname: Utsumi
authors.forename: Ryoichi
authors.initials: R
authors.lastname: Takayanagi
mesh_terms: D000818:Animals; D001921:Brain / Q000000981:diagnostic imaging* / Q000378:metabolism / Q000502:physiology; D060825:Cognitive Dysfunction / Q000209:etiology; D003704:Dementia / Q000209:etiology; D048909:Diabetes Complications / Q000209:etiology*; D004195:Disease Models, Animal; D018450:Disease Progression; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D051379:Mice; D010084:Oxidation-Reduction; D018384:Oxidative Stress / Q000502:physiology*