title: Parameters and outcomes in 525 patients operated on for oral squamous cell carcinoma.
abstract: OBJECTIVE
  This report analyzed the outcomes of patients undergoing surgery for oral squamous cell carcinoma (OSCC) to identify the value of prognostic factors.
  
  
  METHODS
  A total of 525 patients were studied who had undergone surgery for oral squamous cell carcinoma (OSCC) between 2000 and 2011, of whom 222 had received postoperative radiation-therapy (PORT) and or chemoradiation-therapy (PORTC). For each patient, personal data, histological findings, treatment and outcome were recorded and analyzed statistically. Survival curves were calculated using the Kaplan-Meier algorithm, and the difference in survival among subgroups was examined.
  
  
  RESULTS
  The overall survival (OS) and disease-specific survival (DSS) 5-year survival rate in the 525 patients were respectively 71.38% and 73.18%. The differences in the overall survival and disease-specific 5-year survival were significant (p < 0.05) for age < 40 years, site of origin, N status, staging, grading, osseous medullar infiltration, and perineural invasion. In patients undergoing radiation therapy, only perineural invasion negatively influenced the survival prognosis. In 150 pT1 cases of tongue and floor-of-mouth cancer, an infiltration depth (ID) > 4 mm was statistically correlated with poorer prognosis.
  
  
  CONCLUSIONS
  The results demonstrate an improvement in the 5-year OS and DSS rates during the past decade compared with the previous decade. Univariate analysis revealed that age, tumor staging, and lymph node involvement, extracapsular spread, grading, perineurial invasion, infiltration depth, and osseus medullary invasion were associated significantly with overall survival and disease-specific survival.
authors.affiliation: Department of Maxillofacial Surgery, University of Turin, Turin, Italy.
authors.forename: P
authors.initials: P
authors.lastname: Garzino-Demo
authors.affiliation: Department of Maxillofacial Surgery, University of Turin, Turin, Italy. Electronic address: emanuele.zavattero@gmail.com.
authors.forename: E
authors.initials: E
authors.lastname: Zavattero
authors.affiliation: Radiotherapy Department, University of Turin, Turin, Italy.
authors.forename: P
authors.initials: P
authors.lastname: Franco
authors.affiliation: Department of Maxillofacial Surgery, University of Turin, Turin, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Fasolis
authors.affiliation: Department of Maxillofacial Surgery, University of Turin, Turin, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Tanteri
authors.affiliation: Department of Maxillofacial Surgery, University of Turin, Turin, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Mettus
authors.affiliation: Department of Maxillofacial Surgery, University of Turin, Turin, Italy.
authors.forename: P
authors.initials: P
authors.lastname: Tosco
authors.affiliation: Department of Medical Sciences, University of Turin, Turin, Italy.
authors.forename: L
authors.initials: L
authors.lastname: Chiusa
authors.affiliation: Medical Oncology Division, San Giovanni Battista Hospital of Turin, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Airoldi
authors.affiliation: Medical Oncology Division, San Giovanni Battista Hospital of Turin, Italy.
authors.forename: O
authors.initials: O
authors.lastname: Ostellino
authors.affiliation: Medical Oncology Division, San Giovanni Battista Hospital of Turin, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Schena
authors.affiliation: Radiotherapy Department, University of Turin, Turin, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Rampino
authors.affiliation: Radiotherapy Department, University of Turin, Turin, Italy.
authors.forename: U
authors.initials: U
authors.lastname: Ricardi
authors.affiliation: Unit of Cancer Epidemiology, San Giovanni Battista Hospital, University of Turin, Turin, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Evangelista
authors.affiliation: Unit of Cancer Epidemiology, San Giovanni Battista Hospital, University of Turin, Turin, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Merletti
authors.affiliation: Department of Maxillofacial Surgery, University of Turin, Turin, Italy.
authors.forename: S
authors.initials: S
authors.lastname: Berrone
authors.affiliation: Department of Maxillofacial Surgery, University of Turin, Turin, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Ramieri
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D059248:Chemoradiotherapy; D005260:Female; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D009367:Neoplasm Staging; D011379:Prognosis; D018714:Radiotherapy, Adjuvant; D015996:Survival Rate; D016896:Treatment Outcome
keywords: Head and neck cancer; Oral cancer; Squamous cell carcinoma