title: EphA5 and EphA6: regulation of neuronal and spine morphology.
abstract: BACKGROUND
  The Eph family of receptor tyrosine kinases plays important roles in neural development. Previous studies have implicated Eph receptors and their ligands, the ephrins, in neuronal migration, axon bundling and guidance to specific targets, dendritic spine formation and neural plasticity. However, specific contributions of EphA5 and EphA6 receptors to the regulation of neuronal cell morphology have not been well studied.
  
  
  RESULTS
  Here we show that deletion of EphA5 and EphA6 results in abnormal Golgi staining patterns of cells in the brain, and abnormal spine morphology.
  
  
  CONCLUSIONS
  These observations suggest novel functions of these Eph receptors in the regulation of neuronal and spine structure in brain development and function.
authors.affiliation: Susan L. Cullman Laboratory for Cancer Research, Ernest Mario School of Pharmacy, Rutgers University, Piscataway, NJ 08854 USA.
authors.forename: Gitanjali
authors.initials: G
authors.lastname: Das
authors.affiliation: Susan L. Cullman Laboratory for Cancer Research, Ernest Mario School of Pharmacy, Rutgers University, Piscataway, NJ 08854 USA.
authors.forename: Qili
authors.initials: Q
authors.lastname: Yu
authors.affiliation: Susan L. Cullman Laboratory for Cancer Research, Ernest Mario School of Pharmacy, Rutgers University, Piscataway, NJ 08854 USA.
authors.forename: Ryan
authors.initials: R
authors.lastname: Hui
authors.affiliation: Department of Pharmacology and Toxicology, Ernest Mario School of Pharmacy, Rutgers University, Piscataway, NJ 08854 USA.
authors.forename: Kenneth
authors.initials: K
authors.lastname: Reuhl
authors.affiliation: Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591 USA.
authors.forename: Nicholas W
authors.initials: NW
authors.lastname: Gale
authors.affiliation: Susan L. Cullman Laboratory for Cancer Research, Ernest Mario School of Pharmacy, Rutgers University, Piscataway, NJ 08854 USA.
authors.forename: Renping
authors.initials: R
authors.lastname: Zhou
keywords: Cortex; Dendrite; EphA5; EphA6; Golgi staining; Spine