title: Perspectives of ofatumumab as CD20 targeted therapy in rheumatoid arthritis and other autoimmune diseases.
abstract: Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune condition viewed as a severe destructive disease. The treatment strategies include anti-CD20 monoclonal antibody (mAb)-targeting B cells. Ofatumumab specifically targets a membrane-proximal epitope on the CD20 molecule distinct from other anti-CD20 antibodies including rituximab and ocrelizumab, and bind the epitope located on the large loop of CD20. This explains a more durable B-cell depletion and a different pharmacodynamic. We review the pharmacodynamic of B-cell depletion and analyze the results in RA and other B-cell-mediated autoimmune diseases. The randomized trial in RA showed clinical efficacy comparable to rituximab at week 24. However, structural impact has not been demonstrated. Studies including RA patients refractory to rituximab would be useful to define the optimal strategy of ofatumumab therapy.
authors.affiliation: Inserm, U1183, Hôpital Saint-Eloi, Montpellier, F-34295 France.|Université MONTPELLIER, UFR de Médecine, Montpellier, F-34000 France.|Service d'immuno-Rhumatologie, CHU Lapeyronie, Montpellier, F-34295 France.
authors.forename: Yves Marie
authors.initials: YM
authors.lastname: Pers
authors.affiliation: Inserm, U1183, Hôpital Saint-Eloi, Montpellier, F-34295 France.|Université MONTPELLIER, UFR de Médecine, Montpellier, F-34000 France.|Service d'immuno-Rhumatologie, CHU Lapeyronie, Montpellier, F-34295 France.
authors.forename: Christian
authors.initials: C
authors.lastname: Jorgensen
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D000911:Antibodies, Monoclonal / Q000627:therapeutic use*; D061067:Antibodies, Monoclonal, Humanized / Q000627:therapeutic use; D018951:Antigens, CD20 / Q000276:immunology*; D001172:Arthritis, Rheumatoid / Q000276:immunology / Q000628:therapy*; D001327:Autoimmune Diseases / Q000276:immunology / Q000628:therapy*; D001402:B-Lymphocytes / Q000276:immunology*; D006801:Humans; D007167:Immunotherapy / Q000379:methods*; D008212:Lymphocyte Depletion; D016032:Randomized Controlled Trials as Topic; D000069283:Rituximab / Q000627:therapeutic use
chemical_list: D000893:Anti-Inflammatory Agents; D000911:Antibodies, Monoclonal; D061067:Antibodies, Monoclonal, Humanized; D018951:Antigens, CD20; D000069283:Rituximab; C533411:ocrelizumab; C527517:ofatumumab
keywords: anti-CD20; biological; ofatumumab; rheumatoid arthritis