title: Investigation of the correlation between some immune system and biochemical indicators in patients with type 2 diabetes.
abstract: OBJECTIVE
  Since changes in some immune system indicators such as leukocyte count and neutrophil to lymphocyte ratio in the blood and Inflammation is directly in relation with the pathogenesis of type 2 diabetes, metabolic syndrome and atherosclerosis, measuring these indicators in patients with type 2 diabetes and comparing them with control group can be a suitable indicator of Inflammation and prognosis of the disease.
  
  
  METHODS
  The current study was done on 75 patients with type 2 diabetes and 72 healthy individuals as patient and healthy group respectively. The selected groups have been matched for age and sex. Fasting blood sugar, lipid profile including triglycerides, total cholesterol, HDL, LDL, as well as the number of white blood cells, neutrophils, lymphocytes, neutrophils to lymphocytes ratio were measured and analyzed in both groups.
  
  
  RESULTS
  The results demonstrated that there is a significant relationship between the number of white blood cells and increase in blood sugar and also between the neutrophil to lymphocyte ratio and increase in Fasting blood sugar and triglycerides parameters. Furthermore, the average of fasting blood sugar, triglycerides, total cholesterol, LDL and neutrophil to lymphocyte ratio in patient with type 2 diabetes is significantly higher than control group.
  
  
  CONCLUSIONS
  Considering the findings of current study, we showed the inflammation and the pathogenesis caused by type 2 diabetes can be attributed to neutrophil to lymphocyte ratio.
authors.affiliation: Department of Medical Laboratory Sciences, School of Paramedicine, Hamadan University of Medical Sciences, Hamadan, Iran.|Research Center for Molecular Medicine, Hamadan University of Medical Sciences, Hamadan, Iran.|Neurophysiology Research Center, Hamadan University of Medical Sciences, Hamadan, Iran.|Molecularimmunology Research Group, Hamadan University of Medical Sciences, Hamadan, Iran.
authors.forename: Mohammad Mahdi
authors.initials: MM
authors.lastname: Eftekharian
authors.affiliation: Department of Biochemistry, Hamadan University of Medical Sciences, Hamadan, Iran.
authors.forename: Jamshid
authors.initials: J
authors.lastname: Karimi
authors.affiliation: School of Health, Hamadan University of Medical Sciences, Hamadan, Iran.
authors.forename: Mojgansadat
authors.initials: M
authors.lastname: Safe
authors.affiliation: Taamin-e-ejtemaee Hospital, Hamadan, Iran.
authors.forename: Ahmad
authors.initials: A
authors.lastname: Sadeghian
authors.affiliation: Department of Internal Medicine, Faculty of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran.
authors.forename: Shiva
authors.initials: S
authors.lastname: Borzooei
authors.affiliation: Department of Biochemistry, Students Research Center, Hamadan University of Medical Sciences, Hamadan, Iran.
authors.forename: Ehsan
authors.initials: E
authors.lastname: Siahpoushi
mesh_terms: D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D001786:Blood Glucose / Q000378:metabolism; D016022:Case-Control Studies; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000175:diagnosis* / Q000276:immunology / Q000473:pathology; D005215:Fasting; D005260:Female; D006801:Humans; D007249:Inflammation; D018655:Lymphocyte Count; D008214:Lymphocytes / Q000276:immunology* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009504:Neutrophils / Q000276:immunology* / Q000473:pathology; D011379:Prognosis; D014280:Triglycerides / Q000097:blood
chemical_list: D015415:Biomarkers; D001786:Blood Glucose; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D014280:Triglycerides
keywords: Diabetes; inflammation; neutrophil to lymphocyte ratio