title: Regiodivergent Ring-Opening Reaction of Trichloromethylcyclopropane Carboxylates.
abstract: Reagent-controlled regiodivergent ring-opening reactions of trichloromethylcyclopropane carboxylates have been developed. The regioselectivity of bond cleavage is completely controlled by the proper choice of silver salts; the treatment of trichloromethylcyclopropane with AgBF4 led to C2-C3 bond cleavage and fluorination to afford fluorinated β,γ-unsaturated ester with high stereoselectivity, while the reaction with AgOAc in THF gave a γ,δ-unsaturated ester through the reductive cleavage of the C1-C2 bond.
authors.affiliation: Kobe Pharmaceutical University Motoyamakita, Higashinada, Kobe 658-8558, Japan.
authors.forename: Nobuyoshi
authors.initials: N
authors.lastname: Doi
authors.affiliation: Kobe Pharmaceutical University Motoyamakita, Higashinada, Kobe 658-8558, Japan.
authors.forename: Norihiko
authors.initials: N
authors.lastname: Takeda
authors.affiliation: Kobe Pharmaceutical University Motoyamakita, Higashinada, Kobe 658-8558, Japan.
authors.forename: Okiko
authors.initials: O
authors.lastname: Miyata
authors.affiliation: Kobe Pharmaceutical University Motoyamakita, Higashinada, Kobe 658-8558, Japan.
authors.forename: Masafumi
authors.initials: M
authors.lastname: Ueda