title: Functional Translational Readthrough: A Systems Biology Perspective.
abstract: Translational readthrough (TR) has come into renewed focus because systems biology approaches have identified the first human genes undergoing functional translational readthrough (FTR). FTR creates functional extensions to proteins by continuing translation of the mRNA downstream of the stop codon. Here we review recent developments in TR research with a focus on the identification of FTR in humans and the systems biology methods that have spurred these discoveries.
authors.affiliation: University Medical Center, Department of Child and Adolescent Health, University of Göttingen, Göttingen, Germany.
authors.forename: Fabian
authors.initials: F
authors.lastname: Schueren
authors.affiliation: University Medical Center, Department of Child and Adolescent Health, University of Göttingen, Göttingen, Germany.
authors.forename: Sven
authors.identifier: 0000-0003-3018-6363
authors.initials: S
authors.lastname: Thoms
mesh_terms: D000818:Animals; D018388:Codon, Terminator; D004331:Drosophila melanogaster / Q000235:genetics; D023281:Genomics; D006801:Humans; D020675:Peroxisomes / Q000235:genetics*; D014176:Protein Biosynthesis / Q000235:genetics*; D012333:RNA, Messenger / Q000096:biosynthesis / Q000235:genetics; D012270:Ribosomes / Q000235:genetics*; D049490:Systems Biology
chemical_list: D018388:Codon, Terminator; D012333:RNA, Messenger