title: Staphylococcus aureus RNAIII and Its Regulon Link Quorum Sensing, Stress Responses, Metabolic Adaptation, and Regulation of Virulence Gene Expression.
abstract: Staphylococcus aureus RNAIII is one of the main intracellular effectors of the quorum-sensing system. It is a multifunctional RNA that encodes a small peptide, and its noncoding parts act as antisense RNAs to regulate the translation and/or the stability of mRNAs encoding transcriptional regulators, major virulence factors, and cell wall metabolism enzymes. In this review, we explain how regulatory proteins and RNAIII are embedded in complex regulatory circuits to express virulence factors in a dynamic and timely manner in response to stress and environmental and metabolic changes.
authors.affiliation: Architecture et Réactivité de l'ARN, Université de Strasbourg, CNRS, IBMC, 67084 Strasbourg, France; email: p.romby@ibmc-cnrs.unistra.fr.
authors.forename: Delphine
authors.initials: D
authors.lastname: Bronesky
authors.affiliation: College of Veterinary Medicine, Nanjing Agricultural University, Nanjing 210095, China.
authors.forename: Zongfu
authors.initials: Z
authors.lastname: Wu
authors.affiliation: Architecture et Réactivité de l'ARN, Université de Strasbourg, CNRS, IBMC, 67084 Strasbourg, France; email: p.romby@ibmc-cnrs.unistra.fr.
authors.forename: Stefano
authors.initials: S
authors.lastname: Marzi
authors.affiliation: Architecture et Réactivité de l'ARN, Université de Strasbourg, CNRS, IBMC, 67084 Strasbourg, France; email: p.romby@ibmc-cnrs.unistra.fr.
authors.forename: Philippe
authors.initials: P
authors.lastname: Walter
authors.affiliation: Université Claude Bernard Lyon 1, Ecole Normale Supérieure de Lyon, Université de Lyon, INSERM U1111, CNRS UMR 5308, CIRI, 69008 Lyon, France.
authors.forename: Thomas
authors.initials: T
authors.lastname: Geissmann
authors.affiliation: Université Claude Bernard Lyon 1, Ecole Normale Supérieure de Lyon, Université de Lyon, INSERM U1111, CNRS UMR 5308, CIRI, 69008 Lyon, France.
authors.forename: Karen
authors.initials: K
authors.lastname: Moreau
authors.affiliation: Université Claude Bernard Lyon 1, Ecole Normale Supérieure de Lyon, Université de Lyon, INSERM U1111, CNRS UMR 5308, CIRI, 69008 Lyon, France.
authors.forename: François
authors.initials: F
authors.lastname: Vandenesch
authors.affiliation: Architecture et Réactivité de l'ARN, Université de Strasbourg, CNRS, IBMC, 67084 Strasbourg, France; email: p.romby@ibmc-cnrs.unistra.fr.
authors.forename: Isabelle
authors.initials: I
authors.lastname: Caldelari
authors.affiliation: Architecture et Réactivité de l'ARN, Université de Strasbourg, CNRS, IBMC, 67084 Strasbourg, France; email: p.romby@ibmc-cnrs.unistra.fr.
authors.forename: Pascale
authors.initials: P
authors.lastname: Romby
mesh_terms: D000818:Animals; D001426:Bacterial Proteins; D015964:Gene Expression Regulation, Bacterial; D006801:Humans; D053038:Quorum Sensing; D012329:RNA, Bacterial / Q000235:genetics / Q000378:metabolism*; D018085:Regulon; D013203:Staphylococcal Infections / Q000382:microbiology*; D013211:Staphylococcus aureus / Q000201:enzymology* / Q000235:genetics / Q000472:pathogenicity* / Q000502:physiology; D014774:Virulence; D037521:Virulence Factors / Q000235:genetics* / Q000378:metabolism
chemical_list: D001426:Bacterial Proteins; D012329:RNA, Bacterial; C096035:RNAIII, Staphylococcus aureus; D037521:Virulence Factors
keywords: Staphylococcus aureus; posttranscriptional regulation; quorum sensing; regulatory RNAs