title: Homeostasis of chosen bioelements in organs of rats receiving lithium and/or selenium.
abstract: Lithium is an essential trace element, widely used in medicine and its application is often long-term. Despite beneficial effects, its administration can lead to severe side effects including hyperparathyroidism, renal and thyroid disorders. The aim of the current study was to evaluate the influence of lithium and/or selenium treatment on magnesium, calcium and silicon levels in rats' organs as well as the possibility of using selenium as an adjuvant in lithium therapy. The study was performed on rats divided into four groups (six animals each): control-treated with saline; Li-treated with Li2CO3 (2.7 mg Li/kg b.w.); Se-treated with Na2SeO3·H2O (0.5 mg Se/kg b.w.); Se + Li-treated simultaneously with Li2CO3 and Na2SeO3·H2O (2.7 mg Li/kg b.w. and of 0.5 mg Se/kg b.w., respectively). The administration was performed in form of water solutions by stomach tube once a day for 3 weeks. In the organs (liver, kidney, brain, spleen, heart, lung and femoral muscle) the concentrations of magnesium, calcium and silicon were determined. Magnesium was increased in liver of Se and Se + Li given rats. Lithium decreased tissue Ca and co-administration of selenium reversed this effect. Silicon was not affected by any treatment. The beneficial effect of selenium on disturbances of calcium homeostasis let suggest that further research on selenium application as an adjuvant in lithium therapy is worth being performed.
authors.affiliation: Chair and Department of Medical Chemistry, Medical University of Lublin, Chodźki 4a, 20-093, Lublin, Poland.
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Kiełczykowska
authors.affiliation: Chair and Department of Medical Chemistry, Medical University of Lublin, Chodźki 4a, 20-093, Lublin, Poland.
authors.forename: Irena
authors.initials: I
authors.lastname: Musik
authors.affiliation: Chair and Department of Medical Chemistry, Medical University of Lublin, Chodźki 4a, 20-093, Lublin, Poland.
authors.forename: Renata
authors.initials: R
authors.lastname: Żelazowska
authors.affiliation: Chair and Department of Medical Chemistry, Medical University of Lublin, Chodźki 4a, 20-093, Lublin, Poland.
authors.forename: Anna
authors.initials: A
authors.lastname: Lewandowska
authors.affiliation: Chair and Department of Medical Chemistry, Medical University of Lublin, Chodźki 4a, 20-093, Lublin, Poland.
authors.forename: Jacek
authors.initials: J
authors.lastname: Kurzepa
authors.affiliation: Chair and Department of Medical Chemistry, Medical University of Lublin, Chodźki 4a, 20-093, Lublin, Poland. joanna.kocot@umlub.pl.
authors.forename: Joanna
authors.initials: J
authors.lastname: Kocot
mesh_terms: D000284:Administration, Oral; D000818:Animals; D002118:Calcium / Q000032:analysis / Q000493:pharmacokinetics*; D006706:Homeostasis / Q000187:drug effects*; D008094:Lithium / Q000008:administration & dosage / Q000494:pharmacology*; D008274:Magnesium / Q000032:analysis / Q000493:pharmacokinetics*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D012643:Selenium / Q000008:administration & dosage / Q000494:pharmacology*; D012825:Silicon / Q000032:analysis / Q000493:pharmacokinetics*; D014018:Tissue Distribution
chemical_list: D008094:Lithium; D012643:Selenium; D008274:Magnesium; D002118:Calcium; D012825:Silicon
keywords: Calcium; Lithium; Magnesium; Male rats; Selenium; Silicon