title: Modelling the cost-effectiveness of pharmacist-managed anticoagulation service for older adults with atrial fibrillation in Singapore.
abstract: Background Oral anticoagulation with warfarin is the cornerstone therapy in atrial fibrillation (AF) for stroke prevention. Multi-disciplinary anticoagulation management services have been shown to be cost-effective in the United States, Hong Kong and Thailand, but the findings are not readily generalizable to Singapore's healthcare system. Objective This study aimed to evaluate the cost-effectiveness of pharmacist-managed anticoagulation clinic (ACC) compared with usual care (UC) for the management of older adults with AF receiving oral anticoagulation with warfarin. Setting Pharmacist-managed ACC in an academic medical centre. Method A Markov model with 3-month cycle length and 30-year time horizon compared costs and quality-adjusted life-years (QALYs) of ACC and UC from the patient's and healthcare provider's perspectives. Four pathways based on time in therapeutic range (TTR) were: ACC TTR < 70 %, ACC TTR ≥ 70 %, UC TTR < 70 % and UC TTR ≥ 70 %. A hypothetical cohort of 70-year-old Singaporean AF patients receiving warfarin was utilised. Local data from national disease registries, patient surveys and hospital databases were used. When local data was not available, published studies on Asian populations were utilized when available. One-way sensitivity analyses and probabilistic sensitivity analyses were performed to account for uncertainties. Costs and QALYs were discounted annually by 3 %. Main outcome measure Costs and QALYs of ACC and UC. Results Pharmacist-managed ACC was found to dominate UC in all comparisons. It improved effectiveness by 0.19 and 0.13 QALYs at TTR < 70 % and TTR ≥ 70 % respectively compared with UC. From the patient's perspective, ACC reduced costs by SG$1222.67 (€1110.24) for TTR < 70 % and SG$1008.16 (€915.46) for TTR ≥ 70 %. Similar trends were observed from the healthcare provider's perspective, with ACC reducing costs by SG$1444.79 (€1311.94) for TTR < 70 % and SG$1269.17 (€1152.46) for TTR ≥ 70 % compared with UC. The results were robust to variations of the parameters over their plausible ranges in one-way sensitivity analyses. Probabilistic sensitivity analyses demonstrated that ACC was cost-effective more than 79 % of the time from both perspectives at a willingness-to-pay threshold of SG$69,050 (€62,701) per QALY. Conclusion Pharmacist-managed ACC is more effective and less costly compared with UC regardless of the quality of anticoagulation therapy. The findings support the current body of evidence demonstrating the cost-effectiveness of ACC.
authors.affiliation: Department of Pharmacy, KK Women's and Children's Hospital, 100 Bukit Timah Road, Singapore, 229899, Singapore.
authors.forename: Wen Bing Brandon
authors.initials: WB
authors.lastname: Chua
authors.affiliation: Department of Pharmacy, Singapore General Hospital, Block 3 Level 1, Outram Road, Singapore, 169608, Singapore.|Department of Pharmacy, Faculty of Science, National University of Singapore, Block S4A Level 3, 18 Science Drive 4, Singapore, 117543, Singapore.
authors.forename: Hua Heng McVin
authors.initials: HH
authors.lastname: Cheen
authors.affiliation: Department of Pharmacy, Singapore General Hospital, Block 3 Level 1, Outram Road, Singapore, 169608, Singapore.
authors.forename: Ming Chai
authors.initials: MC
authors.lastname: Kong
authors.affiliation: Department of Pharmacy, Singapore General Hospital, Block 3 Level 1, Outram Road, Singapore, 169608, Singapore.
authors.forename: Li Li
authors.initials: LL
authors.lastname: Chen
authors.affiliation: Department of Pharmacy, Faculty of Science, National University of Singapore, Block S4A Level 3, 18 Science Drive 4, Singapore, 117543, Singapore. phawhl@nus.edu.sg.
authors.forename: Hwee Lin
authors.initials: HL
authors.lastname: Wee
mesh_terms: D000368:Aged; D000925:Anticoagulants / Q000191:economics* / Q000627:therapeutic use; D001281:Atrial Fibrillation / Q000188:drug therapy* / Q000191:economics* / Q000453:epidemiology; D001777:Blood Coagulation / Q000187:drug effects; D015331:Cohort Studies; D003362:Cost-Benefit Analysis / Q000379:methods*; D005260:Female; D006801:Humans; D008297:Male; D018803:Models, Economic; D010595:Pharmacists / Q000191:economics*; D024382:Professional Role; D012846:Singapore / Q000453:epidemiology
chemical_list: D000925:Anticoagulants
keywords: Anticoagulation; Atrial fibrillation; Cost-effectiveness; Pharmacist; Singapore; Warfarin