title: Clinical significance of inflammatory mediators in the pathogenesis of oral cancer.
abstract: Oral cancer has become a grave problem in many parts of the globe with two.thirds of the cases occurring in developing countries. Chronic inflammation plays a prominent role in the development of oral cancer. The rationale for molecular targeted prevention of oral cancer is promising. Therefore, there are continued improvements to our understanding of the molecular connections between inflammation and oral cancer. The inflammatory mediators including nuclear factor kappa B, vascular endothelial growth factor, inflammatory cytokines, prostaglandin pathways, p53, reactive oxygen and nitrogen species, and microRNAs are major key players in the pathogenesis of oral cancer. Currently, visual cytology.based techniques and biopsy are used to detect dysplasia and early stage of oral squamous cell carcinoma. These approaches are limited in their ability to judge the severities of oral lesions and are useful only after the appearance of visual changes. Thus, traditional cytological and biopsy assays combined with testing of inflammatory biomarkers would be beneficial for the efficient early detection of oral dysplastic lesions and early stages of oral squamous cell carcinoma.
authors.affiliation: Biochemistry Research Division, The Gujarat Cancer and Research Institute, Ahmedabad, India.
authors.forename: Jayendrakumar B
authors.initials: JB
authors.lastname: Patel
authors.affiliation: Biochemistry Research Division, The Gujarat Cancer and Research Institute, Ahmedabad, India.
authors.forename: Franky D
authors.initials: FD
authors.lastname: Shah
authors.affiliation: Deputy Director, The Gujarat Cancer and Research Institute, Ahmedabad, India.
authors.forename: Geeta M
authors.initials: GM
authors.lastname: Joshi
authors.affiliation: Biochemistry Research Division, The Gujarat Cancer and Research Institute, Ahmedabad, India.
authors.forename: Prabhudas S
authors.initials: PS
authors.lastname: Patel
mesh_terms: D000818:Animals; D002471:Cell Transformation, Neoplastic / Q000378:metabolism*; D003474:Curcumin / Q000494:pharmacology; D016207:Cytokines / Q000378:metabolism; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D007249:Inflammation / Q000150:complications / Q000378:metabolism; D018836:Inflammation Mediators / Q000378:metabolism*; D009062:Mouth Neoplasms / Q000209:etiology* / Q000378:metabolism*; D016328:NF-kappa B / Q000378:metabolism; D009569:Nitric Oxide / Q000378:metabolism; D017382:Reactive Oxygen Species / Q000378:metabolism; D015398:Signal Transduction / Q000187:drug effects; D016159:Tumor Suppressor Protein p53 / Q000235:genetics / Q000378:metabolism; D042461:Vascular Endothelial Growth Factor A / Q000378:metabolism
chemical_list: D016207:Cytokines; D018836:Inflammation Mediators; D016328:NF-kappa B; D017382:Reactive Oxygen Species; D016159:Tumor Suppressor Protein p53; D042461:Vascular Endothelial Growth Factor A; D009569:Nitric Oxide; D003474:Curcumin