title: Dendritic cells and adipose tissue.
abstract: Visceral adipose tissue inflammation in obesity is an established risk factor for metabolic syndrome, which can include insulin resistance, type 2 diabetes, hypertension and cardiovascular diseases. With obesity and related metabolic disorders reaching epidemic proportions globally, an understanding of the mechanisms of adipose tissue inflammation is crucial. Within the immune cell cohort, dendritic cells (DC) play a key role in balancing tolerance and immunity. Despite decades of research into the characterization of DC in lymphoid and non-lymphoid organs, their role in adipose tissue function is poorly understood. There is now an increasing interest in identification and characterization of DC in adipose tissue and understanding their function in regulating tissue metabolic homeostasis. This review provides an overview of the study of DC in adipose tissue, focusing on possible mechanisms by which DC may contribute to adipose tissue homeostasis.
authors.affiliation: William Harvey Research Institute, Barts and the London, Queen Mary University of London, London, UK.
authors.forename: Sandeep
authors.initials: S
authors.lastname: Sundara Rajan
authors.affiliation: William Harvey Research Institute, Barts and the London, Queen Mary University of London, London, UK. m.longhi@qmul.ac.uk.
authors.forename: Maria Paula
authors.initials: MP
authors.lastname: Longhi
mesh_terms: D000273:Adipose Tissue / Q000276:immunology* / Q000473:pathology; D000818:Animals; D003713:Dendritic Cells / Q000276:immunology*; D003924:Diabetes Mellitus, Type 2 / Q000276:immunology*; D006706:Homeostasis; D006801:Humans; D056747:Immunomodulation; D007249:Inflammation; D007333:Insulin Resistance; D009765:Obesity / Q000276:immunology*
keywords: adipose tissue; dendritic cells; inflammation; metabolism; obesity