title: Assessment of antigenic difference of equine influenza virus strains by challenge study in horses.
abstract: We previously reported that horse antiserum against the Japanese equine influenza vaccine virus, A/equine/La Plata/1993 (LP93) exhibited reduced cross-neutralization against some Florida sublineage Clade (Fc) 2 viruses, for example, A/equine/Carlow/2011 (CL11). As a result, Japanese vaccine manufacturers will replace LP93 with A/equine/Yokohama/aq13/2010 (Y10, Fc2). To assess the benefit of updating the vaccine, five horses vaccinated with inactivated Y10 vaccine and five vaccinated with inactivated LP93 were challenged by exposure to a nebulized aerosol of CL11. The durations of pyrexia (≥38.5°C) and other adverse clinical symptoms experienced by the Y10 group were significantly shorter than those of the LP93 group.
authors.affiliation: Equine Research Institute, Japan Racing Association, Shimotsuke, Tochigi, Japan. yamanaka@equinst.go.jp.
authors.forename: Takashi
authors.initials: T
authors.lastname: Yamanaka
authors.affiliation: Equine Research Institute, Japan Racing Association, Shimotsuke, Tochigi, Japan.|Virology Unit, Irish Equine Centre, Johnstown, Naas, Co. Kildare, Ireland.
authors.forename: Manabu
authors.initials: M
authors.lastname: Nemoto
authors.affiliation: Equine Research Institute, Japan Racing Association, Shimotsuke, Tochigi, Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Bannai
authors.affiliation: Equine Research Institute, Japan Racing Association, Shimotsuke, Tochigi, Japan.
authors.forename: Koji
authors.initials: K
authors.lastname: Tsujimura
authors.affiliation: Equine Research Institute, Japan Racing Association, Shimotsuke, Tochigi, Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Kondo
authors.affiliation: Equine Research Institute, Japan Racing Association, Shimotsuke, Tochigi, Japan.
authors.forename: Tomio
authors.initials: T
authors.lastname: Matsumura
authors.affiliation: Virology Unit, Irish Equine Centre, Johnstown, Naas, Co. Kildare, Ireland.
authors.forename: Sarah
authors.initials: S
authors.lastname: Gildea
authors.affiliation: Virology Unit, Irish Equine Centre, Johnstown, Naas, Co. Kildare, Ireland.
authors.forename: Ann
authors.initials: A
authors.lastname: Cullinane
mesh_terms: D000818:Animals; D000914:Antibodies, Viral / Q000097:blood* / Q000276:immunology; D000956:Antigens, Viral / Q000235:genetics / Q000276:immunology*; D006734:Horse Diseases / Q000276:immunology* / Q000821:virology; D006736:Horses; D053123:Influenza A Virus, H3N8 Subtype / Q000276:immunology*; D009980:Influenza A virus / Q000276:immunology; D007252:Influenza Vaccines / Q000276:immunology*; D009976:Orthomyxoviridae Infections / Q000276:immunology / Q000662:veterinary* / Q000821:virology; D015164:Vaccines, Inactivated / Q000008:administration & dosage / Q000276:immunology
chemical_list: D000914:Antibodies, Viral; D000956:Antigens, Viral; D007252:Influenza Vaccines; D015164:Vaccines, Inactivated
keywords: H3N8; challenge study; equine influenza; inactivated whole vaccine