title: AB0 blood types: impact on development of prosthetic mechanical valve thrombosis.
abstract: The non-O alleles of the ABO genotype have been associated with an increased risk of thrombosis. We aimed to assess the association between blood group status and prosthetic valve thrombosis.
  
  
  
  The association between AB0 blood group status and prosthetic valve thrombosis was assessed in this retrospective study. Transesophageal echocardiography was performed in 149 patients with a diagnosis of prosthetic valve thrombosis and in 192 control subjects.
  
  
  
  Non-0 blood group type (p<0.001), presence of NYHA class III-IV status (p<0.001), and central nervous system (p<0.001) and non-central nervous system (p<0.001) emboli were significantly more prevalent in prosthetic valve thrombosis patients than in the control subjects. The incidence of ineffective anticoagulation was higher in patients with prosthetic valve thrombosis than in controls (p<0.001), as was the presence of moderate to severe left atrial spontaneous echo contrast (p<0.001). The non-0 blood prosthetic valve thrombosis subgroup had a higher incidence of obstructive thrombi and central nervous system thrombotic events than having 0 blood prosthetic valve thrombosis subgroup. Non-0 blood group, ineffective anticoagulation, left atrial spontaneous echo contrast, and a poor NYHA functional capacity were identified to be the predictors of prosthetic valve thrombosis.
  
  
  
  Our data demonstrate that patients with non-0 compared with 0 blood groups have higher incidence of prosthetic valve thrombosis and central nervous system embolism and similar rates of non-central nervous system embolism at presentation compared with 0 blood group type. Thus, non-O blood group may be a risk factor that may be prone to the development of prosthetic valve thrombosis in patients with prosthetic heart valves.
authors.affiliation: Department of Cardiology, Evliya Çelebi Training and Research Hospital; Kütahya-Turkey.
authors.forename: Mehmet Ali
authors.initials: MA
authors.lastname: Astarcıoğlu
authors.affiliation: Department of Cardiology, Koşuyolu Kartal Heart Training and Research Hospital; İstanbul-Turkey.
authors.forename: Macit
authors.initials: M
authors.lastname: Kalçık
authors.affiliation: Department of Cardiology, Koşuyolu Kartal Heart Training and Research Hospital; İstanbul-Turkey.
authors.forename: Mahmut
authors.initials: M
authors.lastname: Yesin
authors.affiliation: Department of Cardiology, Koşuyolu Kartal Heart Training and Research Hospital; İstanbul-Turkey.
authors.forename: Mustafa Ozan
authors.initials: MO
authors.lastname: Gürsoy
authors.affiliation: Department of Cardiology, Evliya Çelebi Training and Research Hospital; Ku¨tahya-Turkey.
authors.forename: Taner
authors.initials: T
authors.lastname: Şen
authors.affiliation: Department of Cardiology, Koşuyolu Kartal Heart Training and Research Hospital; İstanbul-Turkey.
authors.forename: Süleyman
authors.initials: S
authors.lastname: Karakoyun
authors.affiliation: Department of Cardiology, Koşuyolu Kartal Heart Training and Research Hospital; İstanbul-Turkey.
authors.forename: Sabahattin
authors.initials: S
authors.lastname: Gündüz
authors.affiliation: Department of Cardiology, Koşuyolu Kartal Heart Training and Research Hospital; İstanbul-Turkey.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Özkan
mesh_terms: D000017:ABO Blood-Group System; D017548:Echocardiography, Transesophageal; D006349:Heart Valve Diseases; D006350:Heart Valve Prosthesis / Q000009:adverse effects*; D006801:Humans; D008943:Mitral Valve; D012189:Retrospective Studies; D013927:Thrombosis / Q000209:etiology*
chemical_list: D000017:ABO Blood-Group System