title: αvβ3 Integrin and tumour blood vessels-learning from the past to shape the future.
abstract: Angiogenesis, the formation of new blood vessels from pre-existing ones, is thought to enhance tumour growth and these blood vessels can act as conduits of tumour cell metastasis. Integrins, the family of cell surface extracellular matrix receptors, can promote endothelial cell migration and survival, both essential features of angiogenesis, and were thus considered good targets for anti-angiogenic therapy. This sparked the development of agents to block integrin function as new cancer therapies. Here, we review the current status of αvβ3-integrin in tumour angiogenesis. Learning from what we now know about integrin conformational changes and endocytosis, we discuss the possible future of targeting blood vessel αvβ3-integrin in the control of cancer.
authors.affiliation: Centre for Tumour Biology, Barts Cancer Institute-a CR-UK Centre of Excellence, Queen Mary University of London, John Vane Science Centre, Charterhouse Square, London EC1 M 6BQ, United Kingdom.
authors.forename: Fevzi
authors.initials: F
authors.lastname: Demircioglu
authors.affiliation: Centre for Tumour Biology, Barts Cancer Institute-a CR-UK Centre of Excellence, Queen Mary University of London, John Vane Science Centre, Charterhouse Square, London EC1 M 6BQ, United Kingdom. Electronic address: k.hodivala-dilke@qmul.ac.uk.
authors.forename: Kairbaan
authors.initials: K
authors.lastname: Hodivala-Dilke
mesh_terms: D000818:Animals; D006801:Humans; D039302:Integrin alphaVbeta3 / Q000378:metabolism*; D008954:Models, Biological; D058990:Molecular Targeted Therapy; D009369:Neoplasms / Q000098:blood supply* / Q000378:metabolism*; D009389:Neovascularization, Pathologic / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D039302:Integrin alphaVbeta3