title: Fampridine and quality of life in individuals with multiple sclerosis.
abstract: BACKGROUND
  Fampridine improves walking in patients with multiple sclerosis (pwMS). However, little is known about its impact on the quality of life (QoL) of pwMS.
  
  
  OBJECTIVE
  This study aimed to evaluate the contribution of fampridine on the QoL of pwMS and to determine if improvements in QoL are best associated with walk respondents.
  
  
  METHODS
  Fifty pwMS were included in this study. The PERSEPP scale and the GaitRite system were used to evaluate QoL and gait respectively. QoL was evaluated 7 days before fampridine (Pre1), on the day the fampridine treatment was initiated (Pre2), and 14 and 21 days after fampridine (Post1 and Post2 respectively). Gait was assessed at Pre-1, Pre-2 and Post-1.
  
  
  RESULTS
  For all patients, fampridine had significant effects (p = 0.05-10(-4), d = 0.25-0.45) on the Overall, Relationship difficulties, Fatigue, Time perspective and Symptoms QoL indices and for gait parameters (p = 0.05-10(-4), d = 0.17-0.38). Non-respondents scored significant effects (p < 0.05-0.01, d = 0.32-0.41) for Overall, Time perspective and Symptoms QoL indices, whereas respondents scored significant effects (p < 0.05-0.01, d = 0.51-0.8) for Overall, Relationship difficulties, Fatigue and Symptoms.
  
  
  CONCLUSIONS
  The QoL of pwMS improved after fampridine, suggesting a real benefit in their lives. However, the contributions to the overall QoL index seem different between groups.
authors.affiliation: Laboratoire d'Exploration Fonctionnelle Clinique du Mouvement, University Hospital of Besançon, 25000 Besançon, France ; Integrative and Clinical Neurosciences EA481, Bourgogne Franche-Comte University, 25000 Besançon, France.
authors.forename: Yoshimasa
authors.identifier: 0000-0002-1024-3095
authors.initials: Y
authors.lastname: Sagawa
authors.affiliation: Regional Memory Centre (CMRR), Department of Neurology, University Hospital of Besançon, 25000 Besançon, France ; Integrative and Clinical Neurosciences EA481, Bourgogne Franche-Comte University, 25000 Besançon, France.
authors.forename: Eloi
authors.initials: E
authors.lastname: Magnin
authors.affiliation: Laboratoire d'Exploration Fonctionnelle Clinique du Mouvement, University Hospital of Besançon, 25000 Besançon, France.
authors.forename: Laura
authors.initials: L
authors.lastname: Paillot
authors.affiliation: Department of Neurology, University Hospital of Besançon, 25000 Besançon, France ; Integrative and Clinical Neurosciences EA481, Bourgogne Franche-Comte University, 25000 Besançon, France.
authors.forename: Thierry
authors.initials: T
authors.lastname: Moulin
authors.affiliation: Laboratoire d'Exploration Fonctionnelle Clinique du Mouvement, University Hospital of Besançon, 25000 Besançon, France ; Integrative and Clinical Neurosciences EA481, Bourgogne Franche-Comte University, 25000 Besançon, France.
authors.forename: Pierre
authors.initials: P
authors.lastname: Decavel
keywords: Fampridine; Gait; Multiple sclerosis; Quality of life