title: Congenital cataract associated with persistent fetal vasculature: findings from IoLunder2.
abstract: PurposeTo describe the frequency, characteristics, and treatment outcome of persistent fetal vasculature (PFV) in children undergoing surgery for congenital and infantile cataract in the first 2 years of life.Patients and methodsObservational population-based cohort study with case identification through active surveillance and standardised data collection via a national clinical network, the British Isles Congenital Cataract Interest Group (BCCIG).ResultsThe IoLunder2 cohort comprises 246 children undergoing surgery for bilateral and unilateral congenital and infantile cataract in the first 2 years of life. A total of 58/246 (24%) children had PFV (%): overall, 46/95 (46%) with unilateral cataract, and 12/141 (8%) with bilateral disease. Anterior segment vascular remnants were more common in bilateral than unilateral disease (75 vs 11%, P=0.01). At 1 year after surgery, 20% of children with bilateral PFV and 24% with unilateral had achieved normal vision for age within the operated eye. The prevalence of post-operative glaucoma was 9% (of children with bilateral disease) and 4% (unilateral).ConclusionPFV is significantly more common than previously reported, and outcomes are comparable to that for congenital and infantile cataract overall.
authors.affiliation: Lifecourse Epidemiology and Biostatistics Section, Population, Policy and Practice Programme, University College London Institute of Child Health, London, UK.|Great Ormond Street Hospital and Institute of Child Heath, NIHR Biomedical Research Centre, London, UK.|Moorfields Eye Hospital and Institute of Ophthalmology, NIHR Biomedical Research Centre, London, UK.|Ulverscroft Vision Research Group, London, UK.
authors.forename: A L
authors.initials: AL
authors.lastname: Solebo
authors.affiliation: Great Ormond Street Hospital and Institute of Child Heath, NIHR Biomedical Research Centre, London, UK.|Ulverscroft Vision Research Group, London, UK.
authors.forename: I
authors.initials: I
authors.lastname: Russell-Eggitt
authors.affiliation: Lifecourse Epidemiology and Biostatistics Section, Population, Policy and Practice Programme, University College London Institute of Child Health, London, UK.|Ulverscroft Vision Research Group, London, UK.
authors.forename: P
authors.initials: P
authors.lastname: Cumberland
authors.affiliation: Lifecourse Epidemiology and Biostatistics Section, Population, Policy and Practice Programme, University College London Institute of Child Health, London, UK.|Great Ormond Street Hospital and Institute of Child Heath, NIHR Biomedical Research Centre, London, UK.|Moorfields Eye Hospital and Institute of Ophthalmology, NIHR Biomedical Research Centre, London, UK.|Ulverscroft Vision Research Group, London, UK.
authors.forename: J S
authors.initials: JS
authors.lastname: Rahi
mesh_terms: D001036:Aphakia, Postcataract / Q000209:etiology*; D002386:Cataract / Q000151:congenital* / Q000503:physiopathology; D002387:Cataract Extraction; D002675:Child, Preschool; D015331:Cohort Studies; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D019654:Lens Implantation, Intraocular; D054514:Persistent Hyperplastic Primary Vitreous / Q000150:complications* / Q000175:diagnosis; D011446:Prospective Studies; D012029:Refraction, Ocular / Q000502:physiology; D006113:United Kingdom; D014792:Visual Acuity / Q000502:physiology