title: Synthesis of Degradable Poly[(Ethylene Glycol)-co-(Glycolic Acid)] via the Post-Polymerization Oxyfunctionalization of Poly(Ethylene Glycol).
abstract: To enhance the limited degradability of poly(ethylene glycol) (PEG), a straightforward method of synthesizing poly[(ethylene glycol)-co-(glycolic acid)] (P(EG-co-GA)) via a ruthenium-catalyzed, post-polymerization oxyfunctionalization of various PEGs is developed. Using this method, a set of copolymers with GA compositions of up to 8 mol% are prepared with minimal reduction in molecular weight (<10%) when compared to their commercially available starting materials. The P(EG-co-GA) copolymers are shown to undergo hydrolysis under mild conditions.
authors.affiliation: Department of Chemistry, The University of Texas at Austin, Austin, TX, 78712, USA.
authors.forename: Di
authors.initials: D
authors.lastname: Liu
authors.affiliation: Center for Multidimensional Carbon Materials (CMCM), Institute for Basic Science (IBS), Ulsan, 44919, Republic of Korea. bielawski@unist.ac.kr.|Department of Chemistry and Department of Energy Engineering, Ulsan National Institute of Science and Technology (UNIST), Ulsan, 44919, Republic of Korea. bielawski@unist.ac.kr.
authors.forename: Christopher W
authors.initials: CW
authors.lastname: Bielawski
mesh_terms: D010100:Oxygen / Q000737:chemistry*; D011091:Polyesters / Q000138:chemical synthesis* / Q000737:chemistry; D011092:Polyethylene Glycols / Q000138:chemical synthesis / Q000737:chemistry*; D058105:Polymerization
chemical_list: D011091:Polyesters; C000617214:poly((ethylene glycol)-co-(glycolic acid)); D011092:Polyethylene Glycols; D010100:Oxygen
keywords: biodegradable polymers; drug delivery systems; poly(ethylene glycol); post-polymerization modification; ruthenium