title: Metastasectomy for Stage IV Melanoma in the Era of Effective Systemic Agents.
abstract: There is an increasing body of literature that strongly suggests that complete metastasectomy for stage IV melanoma can improve overall survival. Before 2011, the efficacy of systemic therapy for melanoma was poor, making surgical resection the mainstay for treatment and the only realistic chance for cure. Now, in just a short time span (2011-2014), we have six Food & Drug Administration (FDA)-approved drugs for patients with stage IV metastatic melanoma. In the absence of prospective clinical trials evaluating the most advantageous sequence and timing for systemic therapy and surgical resection in the setting of stage IV melanoma, the treating surgical and medical oncologists must jointly devise individual treatment plans that take into account the advantages and disadvantages of each modality. This multidisciplinary approach gives the patient the best chance for prolonged survival. This article briefly reviews the FDA-approved systemic therapy options, discusses the data for site-specific metastasectomy, critiques the previous stage IV metastasectomy trials, and presents a view for moving forward with a multidisciplinary approach in mind.
authors.affiliation: The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
authors.forename: David W
authors.initials: DW
authors.lastname: Ollila
authors.affiliation: The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
authors.forename: Nicole E
authors.initials: NE
authors.lastname: Lopez
authors.affiliation: Saint Louis University Hospital, Saint Louis, Missouri.
authors.forename: Eddy C
authors.initials: EC
authors.lastname: Hsueh
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000627:therapeutic use; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use; D002986:Clinical Trials as Topic; D003131:Combined Modality Therapy; D003952:Diagnostic Imaging / Q000379:methods; D019468:Disease Management; D006801:Humans; D008545:Melanoma / Q000175:diagnosis* / Q000401:mortality / Q000601:surgery* / Q000628:therapy; D059146:Metastasectomy / Q000379:methods*; D058990:Molecular Targeted Therapy; D064847:Multimodal Imaging / Q000379:methods; D020360:Neoadjuvant Therapy; D009362:Neoplasm Metastasis; D009367:Neoplasm Staging / Q000379:methods*; D018579:Patient Selection; D011379:Prognosis
chemical_list: D000970:Antineoplastic Agents