title: Intrusive Thoughts Elicited by Direct Electrical Stimulation during Stereo-Electroencephalography.
abstract: Cortical direct electrical stimulation (DES) is a method of brain mapping used during invasive presurgical evaluation of patients with intractable epilepsy. Intellectual auras like intrusive thoughts, also known as forced thinking (FT), have been reported during frontal seizures. However, there are few reports on FT obtained during DES in frontal cortex. We report three cases in which we obtained intrusive thoughts while stimulating the dorsolateral prefrontal cortex and the white matter in the prefrontal region. In order to highlight the effective connectivity that might explain this clinical response, we have analyzed cortico-cortical potentials evoked by single pulse electrical stimulation.
authors.affiliation: Department of Neurology, University Emergency Hospital , Bucharest , Romania.
authors.forename: Irina
authors.initials: I
authors.lastname: Popa
authors.affiliation: Department of Physics, University of Bucharest, Bucharest, Romania; Epilepsy Center, University Hospital of Freiburg, Freiburg, Germany.
authors.forename: Cristian
authors.initials: C
authors.lastname: Donos
authors.affiliation: Department of Physics, University of Bucharest, Bucharest, Romania; FHC Inc., Bowdoin, ME, USA.
authors.forename: Andrei
authors.initials: A
authors.lastname: Barborica
authors.affiliation: Department of Neurosurgery, Bagdasar-Arseni Emergency Hospital , Bucharest , Romania.
authors.forename: Ioan
authors.initials: I
authors.lastname: Opris
authors.affiliation: Department of Neurology, University Emergency Hospital , Bucharest , Romania.
authors.forename: Mihai Dragoş
authors.initials: MD
authors.lastname: Mălîia
authors.affiliation: Department of Physics, University of Bucharest , Bucharest , Romania.
authors.forename: Mirela
authors.initials: M
authors.lastname: Ene
authors.affiliation: Department of Neurological Surgery, Miller School of Medicine, University of Miami , Miami, FL , USA.
authors.forename: Jean
authors.initials: J
authors.lastname: Ciurea
authors.affiliation: Department of Neurology, University Emergency Hospital, Bucharest, Romania; Department of Neurology, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania.
authors.forename: Ioana
authors.initials: I
authors.lastname: Mîndruţă
keywords: brain connectivity; electrical stimulation; epilepsy; forced thinking; prefrontal cortex