title: Au nanoparticles/poly(caffeic acid) composite modified glassy carbon electrode for voltammetric determination of acetaminophen.
abstract: An Au nanoparticles/poly(caffeic acid) (AuNPs/PCA) composite modified glassy carbon (GC) electrode was prepared by successively potentiostatic technique in pH 7.4 phosphate buffer solution containing 0.02mM caffeic acid and 1.0mM HAuCl4. Electrochemical characterization of the AuNPs/PCA-GC electrode was investigated by electrochemical impedance spectroscopy and cyclic voltammetry. The electrochemical behavior of acetaminophen (AP) at the AuNPs/PCA-GC electrode was also studied by cyclic voltammetry. Compared with bare GC and poly(caffeic acid) modified GC electrode, the AuNPs/PCA-GC electrode was exhibited excellent electrocatalytic activity toward the oxidation of AP. The plot of catalytic current versus AP concentration showed two linear segments in the concentration ranges 0.2-20µM and 50-1000µM. The detection limit of 14 nM was obtained by using the first range of the calibration plot. The AuNPs/PCA-GC electrode has been successfully applied and validated by analyzing AP in blood, urine and pharmaceutical samples.
authors.affiliation: College of Science, Northwest A&F University, Yangling, Shaanxi 712100, PR China.
authors.forename: Tianbao
authors.initials: T
authors.lastname: Li
authors.affiliation: College of Science, Northwest A&F University, Yangling, Shaanxi 712100, PR China.
authors.forename: Juan
authors.initials: J
authors.lastname: Xu
authors.affiliation: College of Veterinary Medicine, Northwest A&F University, Yangling, Shaanxi 712100, PR China.
authors.forename: Lei
authors.initials: L
authors.lastname: Zhao
authors.affiliation: College of Science, Northwest A&F University, Yangling, Shaanxi 712100, PR China.
authors.forename: Shaofei
authors.initials: S
authors.lastname: Shen
authors.affiliation: College of Science, Northwest A&F University, Yangling, Shaanxi 712100, PR China.
authors.forename: Maosen
authors.initials: M
authors.lastname: Yuan
authors.affiliation: College of Science, Northwest A&F University, Yangling, Shaanxi 712100, PR China.
authors.forename: Wenming
authors.initials: W
authors.lastname: Liu
authors.affiliation: College of Science, Northwest A&F University, Yangling, Shaanxi 712100, PR China.
authors.forename: Qin
authors.initials: Q
authors.lastname: Tu
authors.affiliation: College of Science, Northwest A&F University, Yangling, Shaanxi 712100, PR China.
authors.forename: Ruijin
authors.initials: R
authors.lastname: Yu
authors.affiliation: College of Science, Northwest A&F University, Yangling, Shaanxi 712100, PR China; College of Veterinary Medicine, Northwest A&F University, Yangling, Shaanxi 712100, PR China. Electronic address: jywang@nwsuaf.edu.cn.
authors.forename: Jinyi
authors.initials: J
authors.lastname: Wang
mesh_terms: D000082:Acetaminophen / Q000032:analysis*; D001774:Blood Chemical Analysis; D002109:Caffeic Acids / Q000737:chemistry*; D002244:Carbon / Q000737:chemistry*; D002623:Chemistry Techniques, Analytical / Q000295:instrumentation*; D004566:Electrodes; D006046:Gold / Q000737:chemistry*; D057230:Limit of Detection; D053768:Metal Nanoparticles / Q000737:chemistry*; D004364:Pharmaceutical Preparations / Q000737:chemistry; D014556:Urine / Q000737:chemistry
chemical_list: D002109:Caffeic Acids; D004364:Pharmaceutical Preparations; D000082:Acetaminophen; D002244:Carbon; D006046:Gold
keywords: Acetaminophen; Cyclic voltammetry; Modified electrode; Nanoparticles; Poly(caffeic acid)