title: Transgenerational transmission of pregestational and prenatal experience: maternal adversity, enrichment, and underlying epigenetic and environmental mechanisms.
abstract: Transgenerational transmission refers to positive and negative adaptations in brain function and behavior that affect following generations. In this paper, empirical findings regarding the transgenerational transmission of maternal adversity during three critical periods - childhood, pregestational adulthood and pregnancy - will be reviewed in terms of pregnancy outcomes, maternal care, offspring behavior and development, and physiological functioning. Research on the transgenerational transmission of enrichment and the implications for interventions to ameliorate the consequences of adversity will also be presented. In the final section, underlying epigenetic and environmental mechanisms that have been proposed to explain how experience is transferred across generations through transgenerational transmission will be reviewed. Directions for future research are suggested throughout.
authors.affiliation: 1Department of Psychology,American University,Washington, DC,USA.
authors.forename: L
authors.initials: L
authors.lastname: Taouk
authors.affiliation: 2Department of Research,The American College of Obstetricians and Gynecologists,Washington, DC,USA.
authors.forename: J
authors.initials: J
authors.lastname: Schulkin
mesh_terms: D044127:Epigenesis, Genetic; D005260:Female; D006801:Humans; D040582:Inheritance Patterns; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D012931:Social Environment; D013315:Stress, Psychological
keywords: adversity; enrichment; epigenetics; prenatal/pregestational; transgenerational