title: A depression network of functionally connected regions discovered via multi-attribute canonical correlation graphs.
abstract: To establish brain network properties associated with major depressive disorder (MDD) using resting-state functional magnetic resonance imaging (Rs-fMRI) data, we develop a multi-attribute graph model to construct a region-level functional connectivity network that uses all voxel level information. For each region pair, we define the strength of the connectivity as the kernel canonical correlation coefficient between voxels in the two regions; and we develop a permutation test to assess the statistical significance. We also construct a network based classifier for making predictions on the risk of MDD. We apply our method to Rs-fMRI data from 20 MDD patients and 20 healthy control subjects in the Predictors of Remission in Depression to Individual and Combined Treatments (PReDICT) study. Using this method, MDD patients can be distinguished from healthy control subjects based on significant differences in the strength of regional connectivity. We also demonstrate the performance of the proposed method using simulationstudies.
authors.affiliation: Department of Biostatistics, University of Michigan, United States. Electronic address: jiankang@umich.edu.
authors.forename: Jian
authors.initials: J
authors.lastname: Kang
authors.affiliation: Department of Biostatistics, Columbia University, United States.
authors.forename: F DuBois
authors.initials: FD
authors.lastname: Bowman
authors.affiliation: Department of Psychiatry Behavioral Sciences, Emory University, United States.
authors.forename: Helen
authors.initials: H
authors.lastname: Mayberg
authors.affiliation: Department of Financial Engineering Operational Research, Princeton University, United States.
authors.forename: Han
authors.initials: H
authors.lastname: Liu
mesh_terms: D000328:Adult; D000465:Algorithms; D001921:Brain / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D063132:Connectome / Q000379:methods; D003627:Data Interpretation, Statistical; D003865:Major Depressive Disorder / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D005260:Female; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D007090:Image Interpretation, Computer-Assisted / Q000379:methods; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D009415:Nerve Net / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013223:Statistics as Topic