title: Is Spectral-Domain Optical Coherence Tomography Always Able to Detect the Anti-Vascular Endothelial Growth Factor Action on Neovascular Membrane?
abstract: OBJECTIVE
  To show the presence of an active neovascular membrane in age-related macular degeneration even if optical coherence tomography (OCT) does not detect intra- or subretinal edema.
  
  
  METHODS
  This is a retrospective case report. During the follow-up after the intravitreal injection, 3 patients showed no intraretinal or subretinal edema by OCT; however, there was a progressive reduction in their visual acuity; thus, a fluorangiography (FA) examination was performed.
  
  
  RESULTS
  In these 3 cases, FA showed an active neovascular network.
  
  
  CONCLUSIONS
  OCT could show a real reduction in the edema, but it is not always able to detect neovessel presence. Intravitreal injection could improve the vessel permeability without care and delete the neovascular network.
authors.affiliation: Casa di Cura Clinica Montallegro, Genoa, Italy.
authors.forename: Luigi
authors.initials: L
authors.lastname: Borgia
authors.affiliation: Laboratorio clinico anatomo-funzionale per la diagnosi e il trattamento del glaucoma e della malattie neurooftalmologiche, Clinica Oculistica, DiNOGMI, University of Genoa, Genoa, Italy.
authors.forename: Chiara
authors.initials: C
authors.lastname: Del Noce
authors.affiliation: Laboratorio clinico anatomo-funzionale per la diagnosi e il trattamento del glaucoma e della malattie neurooftalmologiche, Clinica Oculistica, DiNOGMI, University of Genoa, Genoa, Italy.
authors.forename: Michele
authors.initials: M
authors.lastname: Iester
keywords: Age-related macular degeneration; Intravitreal injection; Spectral-domain optical coherence tomography