title: Considerations for the design, analysis and presentation of in vivo studies.
abstract: To describe, explain and give practical suggestions regarding important principles and key methodological challenges in the study design, statistical analysis, and reporting of results from in vivo studies.
  
  
  
  Pre-specifying endpoints and analysis, recognizing the common underlying assumption of statistically independent observations, performing sample size calculations, and addressing multiplicity issues are important parts of an in vivo study. A clear reporting of results and informative graphical presentations of data are other important parts.
authors.affiliation: Mdas AB, Rotfruktsgatan 12B, SE-27154 Ystad, Sweden. Electronic address: jr@mdas.se.
authors.forename: J
authors.initials: J
authors.lastname: Ranstam
authors.affiliation: Centre for Statistics in Medicine, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Botnar Research Centre Windmill Road, Oxford OX3 7LD, UK. Electronic address: jonathan.cook@csm.ox.ac.uk.
authors.forename: J A
authors.initials: JA
authors.lastname: Cook
mesh_terms: D000818:Animals; D035843:Biomedical Research / Q000379:methods* / Q000592:standards; D002985:Clinical Protocols / Q000592:standards; D003627:Data Interpretation, Statistical; D006801:Humans; D010003:Osteoarthritis / Q000628:therapy*; D011642:Publications / Q000592:standards; D016032:Randomized Controlled Trials as Topic / Q000379:methods / Q000592:standards; D012107:Research Design; D018401:Sample Size
keywords: Analysis plan; Biostatistics; Experimental design; Inference; Results presentation; Study protocol