title: The role of epsilon PKC in acute and chronic diseases: Possible pharmacological implications of its modulators.
abstract: Epsilon Protein kinase C (εPCK) is a particular kinase that, when activated, is able to protect against different stress injuries and therefore has been proposed to be a potential molecular target against acute and chronic diseases. Particular attention has been focused on εPCK for its involvement in the protective mechanism of Ischemic Preconditioning (IPC), a powerful endogenous mechanism characterized by subthreshold ischemic insults able to protect organs against ischemic injury. Therefore, in the past decades several εPCK modulators have been tested with the object to emulate εPCK mediate protection. Among these the most promising, so far, has been the ΨεRACK peptide, a homologous of RACK receptor for εPKC, that when administrated can mimic its effect in the cells. However, results from studies on εPCK indicate controversial role of this kinase in different organs and diseases, such as myocardial infarct, stroke, diabetes and cancer. Therefore, in this review we provide a discussion on the function of εPCK in acute and chronic diseases and how the different activators and inhibitors have been used to modulate its activity. A better understanding of its function is still needed to definitively target εPCK as novel therapeutic strategy.
authors.affiliation: Department of Systems Medicine, School of Medicine, University of Rome Tor Vergata, Rome, Italy.
authors.forename: Barbara
authors.initials: B
authors.lastname: Capuani
authors.affiliation: Department of Systems Medicine, School of Medicine, University of Rome Tor Vergata, Rome, Italy.
authors.forename: Francesca
authors.initials: F
authors.lastname: Pacifici
authors.affiliation: Department of Systems Medicine, School of Medicine, University of Rome Tor Vergata, Rome, Italy.
authors.forename: Donatella
authors.initials: D
authors.lastname: Pastore
authors.affiliation: Department of Biomedical Sciences and Human Oncology, University of Bari ⿿Aldo Moro⿿, Bari, Italy.
authors.forename: Raffaele
authors.initials: R
authors.lastname: Palmirotta
authors.affiliation: Department of Systems Medicine, School of Medicine, University of Rome Tor Vergata, Rome, Italy.
authors.forename: Giulia
authors.initials: G
authors.lastname: Donadel
authors.affiliation: Department of Systems Medicine, School of Medicine, University of Rome Tor Vergata, Rome, Italy.
authors.forename: Roberto
authors.initials: R
authors.lastname: Arriga
authors.affiliation: Department of Systems Medicine, School of Medicine, University of Rome Tor Vergata, Rome, Italy.
authors.forename: Alfonso
authors.initials: A
authors.lastname: Bellia
authors.affiliation: Department of Systems Medicine, School of Medicine, University of Rome Tor Vergata, Rome, Italy.
authors.forename: Nicola
authors.initials: N
authors.lastname: Di Daniele
authors.affiliation: Department of Systems Medicine, School of Medicine, University of Rome Tor Vergata, Rome, Italy.
authors.forename: Paola
authors.initials: P
authors.lastname: Rogliani
authors.affiliation: Department of Translational Medical Sciences, University of Naples ⿿Federico II⿿, Naples, Italy.
authors.forename: Pasquale
authors.initials: P
authors.lastname: Abete
authors.affiliation: Department of Systems Medicine, School of Medicine, University of Rome Tor Vergata, Rome, Italy.
authors.forename: Paolo
authors.initials: P
authors.lastname: Sbraccia
authors.affiliation: IRCCS San Raffaele Pisana, Rome, Italy; San Raffaele Roma Open University, Via di Val Cannuta 247, 00166 Rome, Italy.
authors.forename: Fiorella
authors.initials: F
authors.lastname: Guadagni
authors.affiliation: Department of Systems Medicine, School of Medicine, University of Rome Tor Vergata, Rome, Italy.
authors.forename: Davide
authors.initials: D
authors.lastname: Lauro
authors.affiliation: Department of Systems Medicine, School of Medicine, University of Rome Tor Vergata, Rome, Italy; IRCCS San Raffaele Pisana, Rome, Italy. Electronic address: david.dellamorte@uniroma2.it.
authors.forename: David
authors.initials: D
authors.lastname: Della-Morte
mesh_terms: D000208:Acute Disease; D000818:Animals; D002908:Chronic Disease; D006331:Heart Diseases / Q000378:metabolism / Q000517:prevention & control; D006801:Humans; D008659:Metabolic Diseases / Q000378:metabolism; D009369:Neoplasms / Q000378:metabolism; D000066829:Neuroprotection; D051744:Protein Kinase C-epsilon / Q000378:metabolism*
chemical_list: D051744:Protein Kinase C-epsilon
keywords: Acute diseases; Cancer; Chronic diseases; Epsilon PKC; Epsilon PKC modulators; Ischemic preconditioning; Metabolism