title: Thyroid-Like Follicular Carcinoma of the Kidney.
abstract: Thyroid-like follicular carcinoma of the kidney (TLFCK) is a rare but emerging renal neoplasm that morphologically mimics follicular carcinoma of the thyroid but lacks immunohistochemical expression of thyroid markers such as TTF-1 and thyroglobulin. Here, a case of an incidentally discovered TLFCK in a 27-year-old man is reported. Histologic evaluation demonstrated an encapsulated proliferation of variably sized thyroid follicle-like epithelial-lined spaces filled with colloid-like eosinophilic secretions. Immunohistochemical analysis confirmed lack of expression of the thyroid markers TTF-1 and thyroglobulin with expression of PAX8 and CD10, confirming a neoplasm of renal origin, which correlated to the clinical and radiographic absence of thyroid pathology. In this report, this case is described with an emphasis on the differential diagnosis.
authors.affiliation: 1 Madigan Army Medical Center, Tacoma, WA, USA.
authors.forename: Matthew J
authors.initials: MJ
authors.lastname: Muscara
authors.affiliation: 1 Madigan Army Medical Center, Tacoma, WA, USA.
authors.forename: Novae B
authors.initials: NB
authors.lastname: Simper
authors.affiliation: 2 Womack Army Medical Center, Fort Bragg, NC, USA.
authors.forename: Edwin
authors.initials: E
authors.lastname: Gandia
mesh_terms: D018263:Adenocarcinoma, Follicular / Q000175:diagnosis / Q000473:pathology*; D000328:Adult; D014408:Biomarkers, Tumor / Q000032:analysis; D006801:Humans; D007150:Immunohistochemistry; D007680:Kidney Neoplasms / Q000175:diagnosis / Q000473:pathology*; D008297:Male
chemical_list: D014408:Biomarkers, Tumor
keywords: genitourinary; renal cell carcinoma; thyroid-like follicular carcinoma