title: Bacterial Strategies to Maintain Zinc Metallostasis at the Host-Pathogen Interface.
abstract: Among the biologically required first row, late d-block metals from MnIIto ZnII, the catalytic and structural reach of ZnIIensures that this essential micronutrient touches nearly every major metabolic process or pathway in the cell. Zn is also toxic in excess, primarily because it is a highly competitive divalent metal and will displace more weakly bound transition metals in the active sites of metalloenzymes if left unregulated. The vertebrate innate immune system uses several strategies to exploit this "Achilles heel" of microbial physiology, but bacterial evolution has responded in kind. This review highlights recent insights into transcriptional, transport, and trafficking mechanisms that pathogens use to "win the fight" over zinc and thrive in an otherwise hostile environment.
authors.affiliation: From the Departments of Chemistry and the Departamento de Quimica Inorganica, Analitica y Quimica Fisica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires C1428EHA, Argentina.
authors.forename: Daiana A
authors.initials: DA
authors.lastname: Capdevila
authors.affiliation: From the Departments of Chemistry and Molecular and Cellular Biochemistry, Indiana University, Bloomington, Indiana 47405-7102 and.
authors.forename: Jiefei
authors.initials: J
authors.lastname: Wang
authors.affiliation: From the Departments of Chemistry and Molecular and Cellular Biochemistry, Indiana University, Bloomington, Indiana 47405-7102 and giedroc@indiana.edu.
authors.forename: David P
authors.initials: DP
authors.lastname: Giedroc
mesh_terms: D000818:Animals; D001419:Bacteria / Q000378:metabolism*; D018407:Bacterial Physiological Phenomena; D054884:Host-Pathogen Interactions / Q000502:physiology*; D006801:Humans; D015032:Zinc / Q000378:metabolism*
chemical_list: D015032:Zinc
keywords: ABC transporter; allostery; antibiotics; bacteria; host-pathogen interaction; metal transporter; metallochaperone; metallophores; metalloprotein; metalloregulatory protein; metallostasis; zinc; zinc homeostasis