title: Impairment in subcortical suppression in schizophrenia: Evidence from the fBIRN Oddball Task.
abstract: Schizophrenia patients show widespread impairments in brain activity during oddball tasks, which involve responding to infrequent target stimuli while refraining from responding during continuous non-target stimuli. In a network-based investigation comparing schizophrenia or schizoaffective patients to healthy controls, we sought to clarify which networks were specifically associated with target detection using a multivariate analysis technique that identifies task-specific functional brain networks. We acquired data from the publicly available function biomedical informatics research network collaboration, including 58 patients and 50 controls. Two task-based functional brain networks were identified: (1) a response modulation network including bilateral temporal pole, supramarginal gyrus, striatum, and thalamus, on which patients showed decreased activity relative to controls; and (2) an auditory-motor response activation network, on which patients showed a slower return to baseline than controls, but no difference in peak activation. For both groups, baseline to peak activation of the response modulation network correlated negatively with peak to baseline activity in the response activation network, suggesting a role in suppressing the motor response following targets. Patients' impaired activity in the response modulation network, and subsequent longer return to baseline in the response activation network, correspond with their later and less accurate behavioral performance, suggesting that impairment in suppression of the auditory-motor response activation network could underlie oddball task deficits in schizophrenia. In addition, the magnitude of the activity in the response modulation network was correlated with intensity of delusions of reference, supporting the notion that increased referential ideation is associated with hyperactivity within the subcortical striatal-limbic network. Hum Brain Mapp 37:4640-4653, 2016. © 2016 Wiley Periodicals, Inc.
authors.affiliation: Department of Psychiatry, University of British Columbia, Vancouver, British Colombia, Canada.|BC Mental Health and Addictions Research Institute, Provincial Health Services Authority, Vancouver, British Colombia, Canada.
authors.forename: Katie M
authors.initials: KM
authors.lastname: Lavigne
authors.affiliation: Department of Psychiatry, University of British Columbia, Vancouver, British Colombia, Canada.
authors.forename: Mahesh
authors.initials: M
authors.lastname: Menon
authors.affiliation: Department of Psychiatry, University of British Columbia, Vancouver, British Colombia, Canada.|BC Mental Health and Addictions Research Institute, Provincial Health Services Authority, Vancouver, British Colombia, Canada.
authors.forename: Todd S
authors.initials: TS
authors.lastname: Woodward
mesh_terms: D000328:Adult; D001307:Auditory Perception / Q000502:physiology*; D001921:Brain / Q000000981:diagnostic imaging / Q000503:physiopathology*; D001931:Brain Mapping; D005260:Female; D006801:Humans; D007266:Inhibition, Psychological; D008279:Magnetic Resonance Imaging; D008297:Male; D009043:Motor Activity / Q000502:physiology*; D015999:Multivariate Analysis; D009434:Neural Pathways / Q000000981:diagnostic imaging / Q000503:physiopathology; D009483:Neuropsychological Tests; D011618:Psychotic Disorders / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000523:psychology; D012559:Schizophrenia / Q000000981:diagnostic imaging / Q000503:physiopathology*; D012565:Schizophrenic Psychology; D017603:Signal Detection, Psychological / Q000502:physiology
keywords: functional connectivity; functional magnetic resonance imaging; schizophrenia; target detection