title: From HBV to HPV: Designing vaccines for extensive and intensive vaccination campaigns worldwide.
abstract: HBsAg and HPV L1 proteins - the HBV and HPV antigens utilized in current vaccines - share amino acid sequences with human proteins such as cardiomyopathy-associated protein 5, titin, protein-arginine deiminase, E3 ubiquitin-protein ligase RNF19A, bassoon, G-protein coupled receptor for fatty acids, insulin isoform 2, and mitogen-activated protein kinase kinase kinase 10, inter alia. Many shared peptides are also part of immunopositive epitopes. The data 1) support the possibility of crossreactions between the two viral antigens and human proteins that, when altered, may associate with neuropsychiatric, cardiovascular and metabolic diseases such as multiple sclerosis, amyotrophic lateral sclerosis, diabetes, and sudden death; 2) confirm the concept that only vaccines based on sequences unique to pathogens might nullify potential crossreactivity risks in vaccination protocols.
authors.affiliation: Department of Biosciences, Biotechnologies and Biopharmaceutics, University of Bari, Bari 70126, Italy. Electronic address: darja.kanduc@uniba.it.
authors.forename: Darja
authors.initials: D
authors.lastname: Kanduc
authors.affiliation: Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Tel-Hashomer 5265601, Israel.
authors.forename: Yehuda
authors.initials: Y
authors.lastname: Shoenfeld
mesh_terms: D000595:Amino Acid Sequence; D000956:Antigens, Viral / Q000737:chemistry / Q000276:immunology*; D036022:Capsid Proteins / Q000737:chemistry / Q000276:immunology; D003429:Cross Reactions; D000939:Epitopes / Q000737:chemistry; D006514:Hepatitis B Surface Antigens / Q000737:chemistry / Q000276:immunology*; D017325:Hepatitis B Vaccines / Q000009:adverse effects / Q000737:chemistry / Q000276:immunology*; D006801:Humans; D017589:Immunization Programs; D009856:Oncogene Proteins, Viral / Q000737:chemistry / Q000276:immunology; D053918:Papillomavirus Vaccines / Q000009:adverse effects / Q000737:chemistry / Q000276:immunology*; D014611:Vaccination; D014759:Viral Envelope Proteins / Q000737:chemistry / Q000276:immunology
chemical_list: D000956:Antigens, Viral; D036022:Capsid Proteins; D000939:Epitopes; C114580:HPV L1 protein, Human papillomavirus; D006514:Hepatitis B Surface Antigens; D017325:Hepatitis B Vaccines; C096362:L protein, hepatitis B virus; D009856:Oncogene Proteins, Viral; D053918:Papillomavirus Vaccines; D014759:Viral Envelope Proteins
keywords: Autoimmune reactions; HBV/HPV vaccines; Peptide crossreactivity; Peptide uniqueness concept; Safe and effective vaccines