title: Identification of a prodigiosin cyclization gene in the roseophilin producer and production of a new cyclized prodigiosin in a heterologous host.
authors.affiliation: Department of Medicinal and Life Science, Faculty of Pharmaceutical Sciences, Tokyo University of Science, Chiba, Japan.
authors.forename: Shoko
authors.initials: S
authors.lastname: Kimata
authors.affiliation: Department of Medicinal and Life Science, Faculty of Pharmaceutical Sciences, Tokyo University of Science, Chiba, Japan.
authors.forename: Masumi
authors.initials: M
authors.lastname: Izawa
authors.affiliation: College of Pharmaceutical Sciences, Ritsumeikan University, Shiga, Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Kawasaki
authors.affiliation: Department of Medicinal and Life Science, Faculty of Pharmaceutical Sciences, Tokyo University of Science, Chiba, Japan.
authors.forename: Yoichi
authors.initials: Y
authors.lastname: Hayakawa
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D015964:Gene Expression Regulation, Bacterial / Q000502:physiology; D006575:Heterocyclic Compounds, 3-Ring / Q000378:metabolism; D006801:Humans; D015394:Molecular Structure; D005810:Multigene Family; D011353:Prodigiosin / Q000031:analogs & derivatives* / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D011758:Pyrroles / Q000378:metabolism; D048372:Streptomyces coelicolor / Q000378:metabolism*
chemical_list: D000970:Antineoplastic Agents; D006575:Heterocyclic Compounds, 3-Ring; D011758:Pyrroles; C000628848:propyl-meta-cyclooctylprodiginine; C408872:roseophilin; D011353:Prodigiosin