title: Neuropeptide Y associated with asthma in young adults.
abstract: OBJECTIVE
  Neuropeptide Y, a widely circulating neurotransmitter, plays a pivotal role in energy balance, immunomodulation and asthma, and several NPY polymorphisms are promising genetic risk factors for asthma and obesity. We explored the associations of candidate NPY gene polymorphisms with prevalent asthma and its relationship with obesity in young adult asthma patients free of other chronic medical morbidity.
  
  
  METHODS
  Five common gene variants of NPY (rs16147 (-399T/C), rs17149106 (-602G/T), rs16140 (+1000C/G), rs5573 (+1201A/G), rs5574 (+5327C/T)) previously validated to account for most of the NPY expression in vitro and in vivo were investigated in 126 physician-diagnosed asthma patients without other chronic medical morbidity and 182 healthy controls (21-35years). Plasma levels of NPY, adiponectin, and CRP were determined using ELISA, and IL-6 was measured by Luminex in a subgroup of 70 patients and 69 age- and sex-matched healthy controls.
  
  
  RESULTS
  In logistic regression models controlling for gender and obesity, the CT genotype of rs5574 (OR=0.54, 95%CI: 0.30-0.89) and the GT genotype of rs17149106 (OR=5.58, 95%CI: 1.09-28.54) were significantly associated with asthma. No significant interaction between NPY SNP polymorphisms and obesity were detected. Plasma NPY level was correlated with adiponectin levels (p<0.05). Compared with the healthy controls, patients with asthma had higher BMI (p<0.001), adiponectin (p<0.05), IL-6 (p=0.001) and CRP (p<0.001), and lower NPY levels (p<0.01).
  
  
  CONCLUSIONS
  The CT genotype of rs5574 and the GT genotype of rs17149106 are significantly associated with prevalent asthma.
authors.affiliation: Department of Clinical Psychology and Psychiatry/School of Public Health, Zhejiang University College of Medicine, Hangzhou, China.
authors.forename: Yanxia
authors.initials: Y
authors.lastname: Lu
authors.affiliation: Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR), Singapore.
authors.forename: Anand Kumar
authors.initials: AK
authors.lastname: Andiappan
authors.affiliation: Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR), Singapore.
authors.forename: Bernett
authors.initials: B
authors.lastname: Lee
authors.affiliation: Department of Psychological Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
authors.forename: Roger
authors.initials: R
authors.lastname: Ho
authors.affiliation: Division of Respiratory and Critical Care Medicine, Department of Medicine, National University Hospital System, Singapore.
authors.forename: Tow Keang
authors.initials: TK
authors.lastname: Lim
authors.affiliation: Emergency Medicine Department, National University Health System, Singapore.
authors.forename: Win Sen
authors.initials: WS
authors.lastname: Kuan
authors.affiliation: Department of Pediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
authors.forename: Daniel Yam Thiam
authors.initials: DY
authors.lastname: Goh
authors.affiliation: Emergency Medicine Department, National University Health System, Singapore.
authors.forename: Malcolm
authors.initials: M
authors.lastname: Mahadevan
authors.affiliation: Emergency Medicine Department, National University Health System, Singapore.
authors.forename: Tiong Beng
authors.initials: TB
authors.lastname: Sim
authors.affiliation: Department of Otolaryngology, National University of Singapore, Singapore.
authors.forename: De Yun
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Pediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
authors.forename: Hugo P S
authors.initials: HP
authors.lastname: Van Bever
authors.affiliation: Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR), Singapore.
authors.forename: Olaf
authors.initials: O
authors.lastname: Rotzschke
authors.affiliation: Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR), Singapore.
authors.forename: Anis
authors.initials: A
authors.lastname: Larbi
authors.affiliation: Department of Psychological Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore. Electronic address: pcmngtp@nus.edu.sg.
authors.forename: Tze Pin
authors.initials: TP
authors.lastname: Ng
mesh_terms: D052242:Adiponectin / Q000097:blood; D050154:Adiposity / Q000235:genetics; D000328:Adult; D001249:Asthma / Q000453:epidemiology / Q000235:genetics*; D002097:C-Reactive Protein / Q000378:metabolism; D015897:Comorbidity; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D009478:Neuropeptide Y / Q000097:blood / Q000235:genetics*; D009765:Obesity / Q000453:epidemiology / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D015995:Prevalence; D055815:Young Adult
chemical_list: D052242:Adiponectin; D009478:Neuropeptide Y; D002097:C-Reactive Protein
keywords: Adiposity; Asthma control; Neuropeptide Y polymorphism