title: [Targeting high-risk drugs to optimize clinical pharmacists' intervention].
abstract: OBJECTIVE
  By the Order of 6 April 2011, the pharmacist must validate all the prescriptions containing "high-risk drugs" or those of "patients at risk". To optimize this clinical pharmacy activity, we identified high-risk drugs.
  
  
  METHODS
  A list of high-risk drugs has been established using literature, pharmacists' interventions (PI) performed in our hospital and a survey sent to hospital pharmacists. In a prospective study (analysis of 100 prescriptions for each high-risk drug selected), we have identified the most relevant to target.
  
  
  RESULTS
  We obtained a statistically significant PI rate (P<0.05) for digoxin, oral anticoagulants direct, oral methotrexate and colchicine.
  
  
  CONCLUSIONS
  This method of targeted pharmaceutical validation based on high-risk drugs is relevant to detect patients with high risk of medicine-related illness.
authors.affiliation: Service de pharmacie, hôpital Nord-Ouest, plateau d'Ouilly, BP 80436, 69655 Villefranche-sur-Saône cedex, France. Electronic address: annelaure.mouterde@gmail.com.
authors.forename: Anne-Laure
authors.initials: AL
authors.lastname: Mouterde
authors.affiliation: Service de pharmacie, hôpital Nord-Ouest, plateau d'Ouilly, BP 80436, 69655 Villefranche-sur-Saône cedex, France.
authors.forename: Magali
authors.initials: M
authors.lastname: Bourdelin
authors.affiliation: Service de pharmacie, hôpital Nord-Ouest, plateau d'Ouilly, BP 80436, 69655 Villefranche-sur-Saône cedex, France.
authors.forename: Ophélie
authors.initials: O
authors.lastname: Maison
authors.affiliation: Service de pharmacie, hôpital Nord-Ouest, plateau d'Ouilly, BP 80436, 69655 Villefranche-sur-Saône cedex, France.
authors.forename: Sandra
authors.initials: S
authors.lastname: Coursier
authors.affiliation: Service de pharmacie, hôpital Nord-Ouest, plateau d'Ouilly, BP 80436, 69655 Villefranche-sur-Saône cedex, France.
authors.forename: Hervé
authors.initials: H
authors.lastname: Bontemps
keywords: Clinical pharmacy; Drugs; Hospital; Hôpital; Interventions pharmaceutiques; Médicaments; Pharmacie clinique; Pharmacists’ intervention