title: Evaluation of neuroendocrine tumors with 99mTc-EDDA/HYNIC TOC.
abstract: BACKGROUND
  This paper is the short review of our preliminary results obtained with 99mTc-EDDA/HYNIC-TOC.
  
  
  METHODS
  The total of 495 patients with different neuroendocrine tumors were investigated during last few years.
  
  
  RESULTS
  There have been 334 true positive (TP), 73 true negative (TN), 6 false positive (FP) and 82 false negative findings (FN). Diagnosis was made according to SPECT findings in 122 patients (25%). The mean T/NT ratio for TP cases was significantly higher (p < 0.01) on SPECT (3.12 ± 1.13) than on whole body scan (2.2 ± 0.75). According to our results, overall sensitivity of the method is 80%, specificity 92%, positive predictive value 98%, negative predictive value 47% and accuracy 82%. Fifteen TP patients underwent therapy with 90Y-DOTATATE.
  
  
  CONCLUSIONS
  Scintigraphy of neuroendocrine tumors with 99mTc-Tektrotyd is a useful method for diagnosis, staging and follow up of the patients suspected to have neuroendocrine tumors. SPECT had important role in diagnosis. It is also helpful in the appropriate choice of the therapy, including the peptide receptor radionuclide therapy. In the absence of 68Ga-labeled peptides and PET/CT, the special emphasize should be given to application of SPECT/CT as well as to the radioguided surgery.
authors.affiliation: Center for Nuclear Medicine Clinical Center of Serbia, Faculty of Medicine University of Belgrade. vera.artiko@gmail.com.
authors.forename: Vera
authors.initials: V
authors.lastname: Artiko
authors.forename: Aida
authors.initials: A
authors.lastname: Afgan
authors.forename: Jelena
authors.initials: J
authors.lastname: Petrović
authors.forename: Branislava
authors.initials: B
authors.lastname: Radović
authors.forename: Nebojša
authors.initials: N
authors.lastname: Petrović
authors.forename: Marina
authors.initials: M
authors.lastname: Vlajković
authors.forename: Dragana
authors.initials: D
authors.lastname: Šobić-Šaranović
authors.forename: Vladimir
authors.initials: V
authors.lastname: Obradović
mesh_terms: D004492:Edetic Acid / Q000031:analogs & derivatives* / Q000737:chemistry; D005188:False Negative Reactions; D005189:False Positive Reactions; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis; D018358:Neuroendocrine Tumors / Q000000981:diagnostic imaging* / Q000473:pathology; D015282:Octreotide / Q000031:analogs & derivatives* / Q000737:chemistry; D015609:Organotechnetium Compounds / Q000737:chemistry*; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D015609:Organotechnetium Compounds; C410263:technetium Tc 99m hydrazinonicotinyl-Tyr(3)-octreotide; C026058:EDDA; D004492:Edetic Acid; D015282:Octreotide
keywords: 99mTc-EDDA/HYNIC-TOC; NET; SPECT; scintigraphy