title: Tendinopathy and Tendon Rupture Associated with Statins.
abstract: Use of statins may be associated with certain tendinopathies and tendon ruptures, especially of the Achilles, quadriceps, and distal biceps tendons. Tendinopathy usually occurs within the first year of statin use and improves after the drug therapy is stopped. Systemic conditions with a higher risk of tendon rupture include diabetes, gout, rheumatoid arthritis, and chronic kidney disease. Certain drugs, such as corticosteroids and fluoroquinolones, have also been implicated in tendon ruptures. Patients with these systemic conditions who are taking statins in combination with other drugs that increase the risk of tendon injury should be educated about this risk and alternative treatments, including diet and exercise.
authors.affiliation: Department of Orthopaedic Surgery, Warren Alpert Medical School of Brown University, Rhode Island Hospital, Providence, Rhode Island.
authors.forename: Matthew E
authors.initials: ME
authors.lastname: Deren
authors.affiliation: Department of Orthopaedic Surgery, Warren Alpert Medical School of Brown University, Rhode Island Hospital, Providence, Rhode Island.
authors.forename: Stephen A
authors.initials: SA
authors.lastname: Klinge
authors.affiliation: Wesleyan University, Middletown, Connecticut.|Southern New England Rehabilitation Center, North Providence, Rhode Island.
authors.forename: Nita H
authors.initials: NH
authors.lastname: Mukand
authors.affiliation: Department of Orthopaedic Surgery, Warren Alpert Medical School of Brown University, Rhode Island Hospital, Providence, Rhode Island.|Southern New England Rehabilitation Center, North Providence, Rhode Island.|Tufts University School of Medicine, Medford, Massachusetts.
authors.forename: Jon A
authors.initials: JA
authors.lastname: Mukand
mesh_terms: D000125:Achilles Tendon; D024841:Fluoroquinolones; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000009:adverse effects*; D012421:Rupture; D052256:Tendinopathy / Q000139:chemically induced*; D013708:Tendon Injuries / Q000139:chemically induced*
chemical_list: D024841:Fluoroquinolones; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors