title: Anti-GD2 mAbs and next-generation mAb-based agents for cancer therapy.
abstract: Tumor-specific monoclonal antibodies (mAbs) have demonstrated efficacy in the clinic, becoming an important approach for cancer immunotherapy. Due to its limited expression on normal tissue, the GD2 disialogangloside expressed on neuroblastoma cells is an excellent candidate for mAb therapy. In 2015, dinutuximab (an anti-GD2 mAb) was approved by the US FDA and is currently used in a combination immunotherapeutic regimen for the treatment of children with high-risk neuroblastoma. Here, we review the extensive preclinical and clinical development of anti-GD2 mAbs and the different mechanisms by which they mediate tumor cell killing. In addition, we discuss different mAb-based strategies that capitalize on the targeting ability of anti-GD2 mAbs to potentially deliver, as monotherapy, or in combination with other treatments, improved antitumor efficacy.
authors.affiliation: Department of Human Oncology, University of Wisconsin, Madison, WI, USA.
authors.forename: Zulmarie
authors.initials: Z
authors.lastname: Perez Horta
authors.affiliation: Department of Human Oncology, University of Wisconsin, Madison, WI, USA.
authors.forename: Jacob L
authors.initials: JL
authors.lastname: Goldberg
authors.affiliation: Department of Human Oncology, University of Wisconsin, Madison, WI, USA.|Department of Pediatrics & Genetics, University of Wisconsin School of Medicine & Public Health, Madison, WI, USA.
authors.forename: Paul M
authors.initials: PM
authors.lastname: Sondel
mesh_terms: D000818:Animals; D000911:Antibodies, Monoclonal / Q000627:therapeutic use*; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D004353:Drug Evaluation, Preclinical; D004359:Drug Therapy, Combination; D005732:Gangliosides / Q000276:immunology*; D006801:Humans; D007167:Immunotherapy / Q000379:methods*; D009447:Neuroblastoma / Q000276:immunology / Q000628:therapy*; D016896:Treatment Outcome
chemical_list: D000911:Antibodies, Monoclonal; D000970:Antineoplastic Agents; D005732:Gangliosides; C019403:ganglioside, GD2; C112746:dinutuximab
keywords: cancer immunotherapy; monoclonal antibodies; neuroblastoma