title: Ofatumumab treatment in lupus nephritis patients.
abstract: Rituximab is frequently used in systemic lupus erythematosus; however, side effects such as infusion-related reactions limit its use. In this case report, we describe, for the first time, treatment with ofatumumab in four patients with lupus nephritis. The treatment was well tolerated in three of the patients, and a reduction of proteinuria was seen in all cases. This emphasizes the importance of alternative B-cell-depleting therapies in patients with an initial good response to rituximab, but who develop side effects.
authors.affiliation: Department of Medicine, Rheumatology Unit , Karolinska Institute , Stockholm , Sweden.
authors.forename: Malena Loberg
authors.initials: ML
authors.lastname: Haarhaus
authors.affiliation: Department of Medicine, Rheumatology Unit , Karolinska Institute , Stockholm , Sweden.
authors.forename: Elisabet
authors.initials: E
authors.lastname: Svenungsson
authors.affiliation: Department of Medicine, Rheumatology Unit , Karolinska Institute , Stockholm , Sweden.
authors.forename: Iva
authors.initials: I
authors.lastname: Gunnarsson
keywords: infusion reactions; lupus nephritis; ofatumumab; rituximab; systemic lupus erythematosus