title: Bright and photostable fluorescent probe with aggregation-induced emission characteristics for specific lysosome imaging and tracking.
abstract: We develop a new lysosome-targeting AIE fluorescent probe tetraphenylethene-morpholine (TPE-MPL), by incorporating a typical lysosome-targeting moiety of morpholine into a stable tetraphenylethene skeleton. Due to both the AIE and antenna effects, TPE-MPL possesses superior photostability, appreciable tolerance to microenvironment change and high lysosome targeting ability. Our findings confirm that TPE-MPL is a well-suited imaging agent for targeting lysosome and tracking dynamic movement of lysosome. Moreover, due to its synthetic accessibility, TPE-MPL could be further modified as a dual-functional probe for lysosome, thereby gain further insight into the role of lysosome in biomedical applications.
authors.affiliation: College of Chemistry and Chemical Engineering, Central South University, Changsha, Hunan 410083, PR China.
authors.forename: Jiang
authors.initials: J
authors.lastname: Ouyang
authors.affiliation: College of Chemistry and Chemical Engineering, Central South University, Changsha, Hunan 410083, PR China; Key Laboratory of Luminescent Materials and Devices, South China University of Technology, Guangzhou, Guangdong 510640, PR China.
authors.forename: Qiguang
authors.initials: Q
authors.lastname: Zang
authors.affiliation: College of Chemistry and Chemical Engineering, Central South University, Changsha, Hunan 410083, PR China.
authors.forename: Wansong
authors.initials: W
authors.lastname: Chen
authors.affiliation: College of Chemistry and Chemical Engineering, Central South University, Changsha, Hunan 410083, PR China.
authors.forename: Liqiang
authors.initials: L
authors.lastname: Wang
authors.affiliation: College of Chemistry and Chemical Engineering, Central South University, Changsha, Hunan 410083, PR China.
authors.forename: Shuo
authors.initials: S
authors.lastname: Li
authors.affiliation: Xiangya Hospital, Central South University, Changsha, Hunan 410008, PR China; Xiangya School of Medicine, Central South University, Changsha, Hunan 410008, PR China.
authors.forename: Ren-Yu
authors.initials: RY
authors.lastname: Liu
authors.affiliation: Xiangya Hospital, Central South University, Changsha, Hunan 410008, PR China; Xiangya School of Medicine, Central South University, Changsha, Hunan 410008, PR China.
authors.forename: Yuanyuan
authors.initials: Y
authors.lastname: Deng
authors.affiliation: Xiangya Hospital, Central South University, Changsha, Hunan 410008, PR China.
authors.forename: Zhao-Qian
authors.initials: ZQ
authors.lastname: Liu
authors.affiliation: College of Chemistry and Chemical Engineering, Central South University, Changsha, Hunan 410083, PR China.
authors.forename: Juan
authors.initials: J
authors.lastname: Li
authors.affiliation: College of Chemistry and Chemical Engineering, Central South University, Changsha, Hunan 410083, PR China. Electronic address: dengliu@csu.edu.cn.
authors.forename: Liu
authors.initials: L
authors.lastname: Deng
authors.affiliation: College of Chemistry and Chemical Engineering, Central South University, Changsha, Hunan 410083, PR China. Electronic address: liuyounian@csu.edu.cn.
authors.forename: You-Nian
authors.initials: YN
authors.lastname: Liu
mesh_terms: D005456:Fluorescent Dyes / Q000378:metabolism*; D008247:Lysosomes / Q000378:metabolism*; D061848:Optical Imaging / Q000379:methods*
chemical_list: D005456:Fluorescent Dyes
keywords: Aggregation-induced emission; Fluorescent imaging; Lysosome-targeting; Morpholine; Tetraphenylethene