title: Is the Mouse a Good Model of Human PPARγ-Related Metabolic Diseases?
abstract: With the increasing number of patients affected with metabolic diseases such as type 2 diabetes, obesity, atherosclerosis and insulin resistance, academic researchers and pharmaceutical companies are eager to better understand metabolic syndrome and develop new drugs for its treatment. Many studies have focused on the nuclear receptor peroxisome proliferator-activated receptor gamma (PPARγ), which plays a crucial role in adipogenesis and lipid metabolism. These studies have been able to connect this transcription factor to several human metabolic diseases. Due to obvious limitations concerning experimentation in humans, animal models-mainly mouse models-have been generated to investigate the role of PPARγ in different tissues. This review focuses on the metabolic features of human and mouse PPARγ-related diseases and the utility of the mouse as a model.
authors.affiliation: Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Debrecen, Debrecen H-4012, Hungary. papa@med.unideb.hu.
authors.forename: Attila
authors.initials: A
authors.lastname: Pap
authors.affiliation: Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Debrecen, Debrecen H-4012, Hungary. ixchelt.cuaranta@med.unideb.hu.
authors.forename: Ixchelt
authors.initials: I
authors.lastname: Cuaranta-Monroy
authors.affiliation: Sanford Burnham Prebys Medical Discovery Institute at Lake Nona, Orlando, FL 32877, USA. mpeloquin@sbpdiscovery.org.
authors.forename: Matthew
authors.initials: M
authors.lastname: Peloquin
authors.affiliation: Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Debrecen, Debrecen H-4012, Hungary. lnagy@sbpdiscovery.org.|Sanford Burnham Prebys Medical Discovery Institute at Lake Nona, Orlando, FL 32877, USA. lnagy@sbpdiscovery.org.|MTA-DE "Lendulet" Immunogenomics Research Group, University of Debrecen, Debrecen H-4012, Hungary. lnagy@sbpdiscovery.org.
authors.forename: Laszlo
authors.initials: L
authors.lastname: Nagy
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D006801:Humans; D008659:Metabolic Diseases / Q000503:physiopathology*; D051379:Mice; D047495:PPAR gamma / Q000378:metabolism*
chemical_list: D047495:PPAR gamma
keywords: PPARγ expression; human mutations; ligand activation; lipodystrophy; metabolic syndrome; mouse models