title: Tumor evasion of humoral immunity mediated by proteolytic impairment of antibody triggered immune effector function.
abstract: Immune suppression is recognized as a hallmark of cancer and this notion is largely based on studies on cellular immunity. Our recent studies have demonstrated a potential new mechanism of cancer suppression of immunity by impairment of antibody effector function mediated by proteolytic enzymes in the tumor microenvironment.
authors.affiliation: The Texas Therapeutics Institute, Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Centerl at Houston , Hosuton, TX, USA.
authors.forename: Ningyan
authors.initials: N
authors.lastname: Zhang
authors.affiliation: The Texas Therapeutics Institute, Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Centerl at Houston , Hosuton, TX, USA.
authors.forename: Robert E
authors.initials: RE
authors.lastname: Jordan
authors.affiliation: The Texas Therapeutics Institute, Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Centerl at Houston , Hosuton, TX, USA.
authors.forename: Zhiqiang
authors.initials: Z
authors.lastname: An
keywords: Antibody immunity; cancer immune evasion; single proteolytic cleavage of the IgG hinge; tumor microenvironment