title: A Five-Gene Expression Signature Predicts Clinical Outcome of Ovarian Serous Cystadenocarcinoma.
abstract: Ovarian serous cystadenocarcinoma is a common malignant tumor of female genital organs. Treatment is generally less effective as patients are usually diagnosed in the late stage. Therefore, a well-designed prognostic marker provides valuable data for optimizing therapy. In this study, we analyzed 303 samples of ovarian serous cystadenocarcinoma and the corresponding RNA-seq data. We observed the correlation between gene expression and patients' survival and eventually established a risk assessment model of five factors using Cox proportional hazards regression analysis. We found that the survival time in high-risk patients was significantly shorter than in low-risk patients in both training and testing sets after Kaplan-Meier analysis. The AUROC value was 0.67 when predicting the survival time in testing set, which indicates a relatively high specificity and sensitivity. The results suggest diagnostic and therapeutic applications of our five-gene model for ovarian serous cystadenocarcinoma.
authors.affiliation: State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing 210023, China.
authors.forename: Li-Wei
authors.identifier: 0000-0002-4045-7588
authors.initials: LW
authors.lastname: Liu
authors.affiliation: State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing 210023, China.
authors.forename: Qiuhao
authors.identifier: 0000-0002-9886-7731
authors.initials: Q
authors.lastname: Zhang
authors.affiliation: School of Life Sciences, Shanghai University, Shanghai 200444, China.
authors.forename: Wenna
authors.initials: W
authors.lastname: Guo
authors.affiliation: State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing 210023, China.
authors.forename: Kun
authors.identifier: 0000-0001-6390-1509
authors.initials: K
authors.lastname: Qian
authors.affiliation: State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing 210023, China.
authors.forename: Qiang
authors.identifier: 0000-0003-2907-9851
authors.initials: Q
authors.lastname: Wang
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D018284:Cystadenocarcinoma, Serous / Q000235:genetics*; D003710:Demography; D005260:Female; D020869:Gene Expression Profiling; D015972:Gene Expression Regulation, Neoplastic; D052138:Genes, Neoplasm; D006801:Humans; D053208:Kaplan-Meier Estimate; D008875:Middle Aged; D008954:Models, Biological; D008957:Models, Genetic; D010051:Ovarian Neoplasms / Q000235:genetics*; D016016:Proportional Hazards Models; D012372:ROC Curve; D015203:Reproducibility of Results; D016896:Treatment Outcome