title: Tissue-Resident CD169(+) Macrophages Form a Crucial Front Line against Plasmodium Infection.
abstract: Tissue macrophages exhibit diverse functions, ranging from the maintenance of tissue homeostasis, including clearance of senescent erythrocytes and cell debris, to modulation of inflammation and immunity. Their contribution to the control of blood-stage malaria remains unclear. Here, we show that in the absence of tissue-resident CD169(+) macrophages, Plasmodium berghei ANKA (PbA) infection results in significantly increased parasite sequestration, leading to vascular occlusion and leakage and augmented tissue deposition of the malarial pigment hemozoin. This leads to widespread tissue damage culminating in multiple organ inflammation. Thus, the capacity of CD169(+) macrophages to contain the parasite burden and its sequestration into different tissues and to limit infection-induced inflammation is crucial to mitigating Plasmodium infection and pathogenesis.
authors.affiliation: Nanyang Technological University, School of Biological Sciences, 60 Nanyang Drive, Singapore 637551, Singapore.
authors.forename: Pravesh
authors.initials: P
authors.lastname: Gupta
authors.affiliation: Nanyang Technological University, School of Biological Sciences, 60 Nanyang Drive, Singapore 637551, Singapore; Singapore Immunology Network, Agency for Science, Technology and Research (A(∗)STAR), 8A Biomedical Grove, Singapore 138648, Singapore.
authors.forename: Si Min
authors.initials: SM
authors.lastname: Lai
authors.affiliation: Nanyang Technological University, School of Biological Sciences, 60 Nanyang Drive, Singapore 637551, Singapore.
authors.forename: Jianpeng
authors.initials: J
authors.lastname: Sheng
authors.affiliation: Nanyang Technological University, School of Biological Sciences, 60 Nanyang Drive, Singapore 637551, Singapore.
authors.forename: Piotr
authors.initials: P
authors.lastname: Tetlak
authors.affiliation: Singapore Immunology Network, Agency for Science, Technology and Research (A(∗)STAR), 8A Biomedical Grove, Singapore 138648, Singapore.
authors.forename: Akhila
authors.initials: A
authors.lastname: Balachander
authors.affiliation: Singapore Immunology Network, Agency for Science, Technology and Research (A(∗)STAR), 8A Biomedical Grove, Singapore 138648, Singapore.
authors.forename: Carla
authors.initials: C
authors.lastname: Claser
authors.affiliation: Nanyang Technological University, School of Biological Sciences, 60 Nanyang Drive, Singapore 637551, Singapore; Singapore Immunology Network, Agency for Science, Technology and Research (A(∗)STAR), 8A Biomedical Grove, Singapore 138648, Singapore.
authors.forename: Laurent
authors.initials: L
authors.lastname: Renia
authors.affiliation: Nanyang Technological University, School of Biological Sciences, 60 Nanyang Drive, Singapore 637551, Singapore.
authors.forename: Klaus
authors.initials: K
authors.lastname: Karjalainen
authors.affiliation: Nanyang Technological University, School of Biological Sciences, 60 Nanyang Drive, Singapore 637551, Singapore. Electronic address: ruedl@ntu.edu.sg.
authors.forename: Christiane
authors.initials: C
authors.lastname: Ruedl
mesh_terms: D000818:Animals; D004912:Erythrocytes / Q000469:parasitology; D006420:Hemeproteins / Q000378:metabolism; D008264:Macrophages / Q000469:parasitology* / Q000473:pathology; D008288:Malaria / Q000276:immunology*; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D008822:Mice, Transgenic; D010962:Plasmodium berghei / Q000469:parasitology*; D063267:Sialic Acid Binding Ig-like Lectin 1 / Q000235:genetics*
chemical_list: D006420:Hemeproteins; D063267:Sialic Acid Binding Ig-like Lectin 1; C571167:Siglec1 protein, mouse; C020753:hemozoin