title: Limitations and pitfalls of 99mTc-EDDA/HYNIC-TOC (Tektrotyd) scintigraphy.
abstract: Tektrotyd kit was developed by Polatom company for 99mTc labeling to make an alternative tracer of somatostatin receptor scintigraphy available. Since 2005, 99mTc-EDDA/HYNIC-Tyr3-Octreotide has been used in clinical imaging and achieved high impact in management of patients with neuroendocrine tumors. Knowing the limitations and pitfalls is essential to provide ac-curate diagnosis. Therefore, the potential pitfalls associated with the use of 99mTc-EDDA/HYNIC-TOC are reviewed on the basis of own experience. Data were analyzed of 310 patients who underwent somatostatin receptor scintigraphy with 99mTc-Tektrotyd. Pitfalls during radiolabeling process or acquisition can worsen the sensitivity of SRS (somatostatin receptor scintigraphy). Recognizing physi-ological and clinical pitfalls, the diagnostic accuracy will improve.
authors.affiliation: ScanoMed Ltd, Department of Diagnostic Imaging, University of Debrecen. garai.ildiko@scanomed.hu.
authors.forename: Ildikó
authors.initials: I
authors.lastname: Garai
authors.forename: Sandor
authors.initials: S
authors.lastname: Barna
authors.forename: Gabor
authors.initials: G
authors.lastname: Nagy
authors.forename: Attila
authors.initials: A
authors.lastname: Forgacs
mesh_terms: D004492:Edetic Acid / Q000031:analogs & derivatives* / Q000737:chemistry; D006801:Humans; D015282:Octreotide / Q000031:analogs & derivatives* / Q000737:chemistry / Q000378:metabolism; D015609:Organotechnetium Compounds / Q000737:chemistry* / Q000378:metabolism; D011877:Radionuclide Imaging / Q000379:methods*; D012680:Sensitivity and Specificity
chemical_list: D015609:Organotechnetium Compounds; C410263:technetium Tc 99m hydrazinonicotinyl-Tyr(3)-octreotide; C026058:EDDA; D004492:Edetic Acid; D015282:Octreotide
keywords: 99mTc-EDDA/HYNIC-Tyr3-octreotide; pitfalls; somatostatin receptor scintigraphy