title: Genetic polymorphisms influence on the response to clopidogrel in peripheral artery disease patients following percutaneous transluminal angioplasty.
abstract: To study the association of ABCB1 and CYP2C19 polymorphisms and the clopidogrel response in Spanish peripheral artery disease patients following percutaneous transluminal angioplasty (PTA) and to perform a meta-analysis.
  
  
  
  72 patients were recruited and 122 patients included in the meta-analysis. We evaluated the effect of ABCB1 3435 C>T, CYP2C19*2 and CYP2C19*3 and primary end point (restenosis/occlusion of the treated lesions) during 12 months after PTA.
  
  
  
  CYP2C19*2 and/or ABCB1 TT patients were associated with primary end point (OR: 5.00; 95% CI: 1.75-14.27). The meta-analysis confirmed the association of CYP2C19*2 and new atherothrombotic ischemic events (OR: 5.40; 95% CI: 2.30-12.70).
  
  
  
  The CYP2C19 and ABCB1 polymorphisms could be genetic markers of cardiovascular events in peripheral artery disease patients following PTA treated with clopidogrel.
authors.affiliation: Department of Clinical Pharmacy, San Cecilio University Hospital, Institute for Biomedical Research, ibs.GRANADA, Spain.
authors.forename: Xando
authors.initials: X
authors.lastname: Díaz-Villamarín
authors.affiliation: Department of Clinical Pharmacy, San Cecilio University Hospital, Institute for Biomedical Research, ibs.GRANADA, Spain.
authors.forename: Cristina Lucía
authors.initials: CL
authors.lastname: Dávila-Fajardo
authors.affiliation: Genomics Unit, Centre for Genomics & Oncological Research (GENYO), Pfizer University of Granada-Andalusian Regional Government, Health Sciences Technology Park, Granada, Spain.
authors.forename: Luis Javier
authors.initials: LJ
authors.lastname: Martínez-González
authors.affiliation: Bioinformatics Unit, Centre for Genomics & Oncological Research (GENYO), Pfizer University of Granada-Andalusian Regional Government, Health Sciences Technology Park, Granada, Spain.
authors.forename: Pedro
authors.initials: P
authors.lastname: Carmona-Sáez
authors.affiliation: Department of Cardiology, San Cecilio University Hospital, Institute for Biomedical Research, ibs.GRANADA, Spain.
authors.forename: Jesús
authors.initials: J
authors.lastname: Sánchez-Ramos
authors.affiliation: Department of Clinical Pharmacy, San Cecilio University Hospital, Institute for Biomedical Research, ibs.GRANADA, Spain.|Genomics Unit, Centre for Genomics & Oncological Research (GENYO), Pfizer University of Granada-Andalusian Regional Government, Health Sciences Technology Park, Granada, Spain.
authors.forename: María Jesús
authors.initials: MJ
authors.lastname: Álvarez Cubero
authors.affiliation: Department of Vascular Surgery, San Cecilio University Hospital, Institute for Biomedical Research, ibs.GRANADA, Spain.
authors.forename: Luis Miguel
authors.initials: LM
authors.lastname: Salmerón-Febres
authors.affiliation: Department of Clinical Pharmacy, San Cecilio University Hospital, Institute for Biomedical Research, ibs.GRANADA, Spain.
authors.forename: Jose
authors.initials: J
authors.lastname: Cabeza Barrera
authors.affiliation: Department of Vascular Surgery, San Cecilio University Hospital, Institute for Biomedical Research, ibs.GRANADA, Spain.
authors.forename: Fidel
authors.initials: F
authors.lastname: Fernández-Quesada
mesh_terms: D018435:ATP Binding Cassette Transporter, Subfamily B / Q000235:genetics; D000368:Aged; D017130:Angioplasty; D050197:Atherosclerosis / Q000235:genetics / Q000601:surgery; D000077144:Clopidogrel; D065731:Cytochrome P-450 CYP2C19 / Q000235:genetics; D005260:Female; D005838:Genotype; D006083:Graft Occlusion, Vascular / Q000453:epidemiology / Q000235:genetics; D006801:Humans; D035002:Lower Extremity / Q000098:blood supply; D008297:Male; D058729:Peripheral Arterial Disease / Q000188:drug therapy* / Q000235:genetics*; D010975:Platelet Aggregation Inhibitors / Q000627:therapeutic use*; D011110:Polymorphism, Genetic / Q000235:genetics*; D013030:Spain; D013988:Ticlopidine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D016896:Treatment Outcome
chemical_list: C513055:ABCB1 protein, human; D018435:ATP Binding Cassette Transporter, Subfamily B; D010975:Platelet Aggregation Inhibitors; D000077144:Clopidogrel; C045793:CYP2C19 protein, human; D065731:Cytochrome P-450 CYP2C19; D013988:Ticlopidine
keywords: SNP; clopidogrel; percutaneous transluminal angioplasty; pharmacogenetics