title: Oxidative stress status in Chinese women with different clinical phenotypes of polycystic ovary syndrome.
abstract: OBJECTIVE
  To determine oxidative stress status and its association with clinical and metabolic parameters in Chinese women with different clinical phenotypes of polycystic ovary syndrome (PCOS).
  
  
  METHODS
  A cross-sectional study.
  
  
  METHODS
  A total of 544 patients with PCOS and 468 control women were included.
  
  
  METHODS
  The total oxidant status (TOS) was determined using a microplate colorimetric method. Total antioxidant capacity (T-AOC), oxidative stress index (OSI, the ratios of TOS to T-AOC) and clinical, hormonal and metabolic parameters were also analysed.
  
  
  RESULTS
  TOS and OSI were significantly higher in each of the four PCOS phenotypes based on the Rotterdam criteria than in the control women and higher in patients with hyperandrogenism (HA) than in those without HA (P < 0·05). TOS, T-AOC and OSI were higher in lean patients than in lean controls (P < 0·05). These values, except OSI, were also higher in overweight/obese patients than in lean patients, and lean or overweight/obese controls (P < 0·05). Multivariate regression analysis demonstrated that apolipoprotein (apo)A1, the Ferriman-Gallwey score, triglyceride (TG), oestradiol (E2), high-density lipoprotein cholesterol (HDL-C) and 2-h glucose levels were the main predictors of TOS; the Ferriman-Gallwey score, E2, apoA1, TG and HDL-C levels were the main predictors of OSI.
  
  
  CONCLUSIONS
  Patients with PCOS with HA have higher oxidative stress levels compared with those without HA. The increased oxidative stress in PCOS is related to HA status, increased plasma glucose, TG, HDL-C and E2levels, decreased apoA1 concentrations and a relative shortage of antioxidant capacity.
authors.affiliation: Laboratory of Genetic Disease and Perinatal Medicine, Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, Chengdu, China.
authors.forename: Renjiao
authors.initials: R
authors.lastname: Zhang
authors.affiliation: Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, Chengdu, China.
authors.forename: Hongwei
authors.initials: H
authors.lastname: Liu
authors.affiliation: Laboratory of Genetic Disease and Perinatal Medicine, Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, Chengdu, China.
authors.forename: Huai
authors.initials: H
authors.lastname: Bai
authors.affiliation: Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, Chengdu, China.
authors.forename: Yujin
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Laboratory of Genetic Disease and Perinatal Medicine, Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, Chengdu, China.
authors.forename: Qingqing
authors.initials: Q
authors.lastname: Liu
authors.affiliation: Laboratory of Genetic Disease and Perinatal Medicine, Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, Chengdu, China.
authors.forename: Linbo
authors.initials: L
authors.lastname: Guan
authors.affiliation: Laboratory of Genetic Disease and Perinatal Medicine, Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, Chengdu, China.
authors.forename: Ping
authors.initials: P
authors.lastname: Fan
mesh_terms: D000328:Adult; D044466:Asian People; D002681:China; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D009765:Obesity / Q000150:complications / Q000378:metabolism; D018384:Oxidative Stress; D010641:Phenotype; D011085:Polycystic Ovary Syndrome / Q000150:complications / Q000378:metabolism*; D055815:Young Adult