title: Multi-component determination and chemometric analysis of Paris polyphylla by ultra high performance liquid chromatography with photodiode array detection.
abstract: Multi-source analysis of traditional Chinese medicine is key to ensuring its safety and efficacy. Compared with traditional experimental differentiation, chemometric analysis is a simpler strategy to identify traditional Chinese medicines. Multi-component analysis plays an increasingly vital role in the quality control of traditional Chinese medicines. A novel strategy, based on chemometric analysis and quantitative analysis of multiple components, was proposed to easily and effectively control the quality of traditional Chinese medicines such as Chonglou. Ultra high performance liquid chromatography was more convenient and efficient. Five species of Chonglou were distinguished by chemometric analysis and nine saponins, including Chonglou saponins I, II, V, VI, VII, D, and H, as well as dioscin and gracillin, were determined in 18 min. The method is feasible and credible, and enables to improve quality control of traditional Chinese medicines and natural products.
authors.affiliation: National Institutes for Food and Drug Control, Beijing, China.
authors.forename: Pei
authors.initials: P
authors.lastname: Chen
authors.affiliation: National Institutes for Food and Drug Control, Beijing, China.
authors.forename: Hong-Yu
authors.initials: HY
authors.lastname: Jin
authors.affiliation: National Institutes for Food and Drug Control, Beijing, China.|Xinjiang Institute for Food and Drug Control, Urumqi, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Sun
authors.affiliation: National Institutes for Food and Drug Control, Beijing, China. masc@nicpbp.org.cn.
authors.forename: Shuang-Cheng
authors.initials: SC
authors.lastname: Ma
mesh_terms: D002851:Chromatography, High Pressure Liquid / Q000295:instrumentation / Q000379:methods*; D004144:Diosgenin / Q000031:analogs & derivatives / Q000737:chemistry; D004365:Drugs, Chinese Herbal / Q000737:chemistry*; D019668:Liliaceae / Q000737:chemistry*; D011786:Quality Control; D012503:Saponins / Q000737:chemistry
chemical_list: D004365:Drugs, Chinese Herbal; D012503:Saponins; C019357:dioscin; D004144:Diosgenin
keywords: Chemometric analysis; Multi-component determination; Paridis Rhizoma; Traditional Chinese medicine; Ultra high performance liquid chromatography