title: Air-Stable Pd Catalytic Systems for Sequential One-Pot Synthesis of Challenging Unsymmetrical Aminoaromatics.
abstract: The selective functionalization of dibromoaromatic scaffolds using air-stable palladium catalytic systems was carried out. This methodology involved rapid mono and diselective Buchwald-Hartwig aminations via microwave irradiation. The conditions were optimized to couple sequentially different moieties in one pot. Couplings with a wide scope of amines allowed accessing a new library of symmetrical and unsymmetrical derivatives (35 examples). Using this versatile method, a near-IR push-pull sensor was prepared installing the electron-donating and -withdrawing groups through a multicomponent reaction. These conditions revealed to be gram-scalable and adaptable to various groups; hence, promoting facile use in synthetic chemistry.
authors.affiliation: Institut de Chimie de Nice, UMR 7272, Université de Nice Sophia Antipolis, CNRS , Parc Valrose, 06108 Nice, Cedex 2, France.
authors.forename: Janah
authors.initials: J
authors.lastname: Shaya
authors.affiliation: Institut de Chimie de Nice, UMR 7272, Université de Nice Sophia Antipolis, CNRS , Parc Valrose, 06108 Nice, Cedex 2, France.
authors.forename: Marie-Angélique
authors.initials: MA
authors.lastname: Deschamps
authors.affiliation: Institut de Chimie de Nice, UMR 7272, Université de Nice Sophia Antipolis, CNRS , Parc Valrose, 06108 Nice, Cedex 2, France.
authors.forename: Benoît Y
authors.initials: BY
authors.lastname: Michel
authors.affiliation: Institut de Chimie de Nice, UMR 7272, Université de Nice Sophia Antipolis, CNRS , Parc Valrose, 06108 Nice, Cedex 2, France.
authors.forename: Alain
authors.initials: A
authors.lastname: Burger