title: Construction of the 1,5-Benzodiazepine Skeleton from o-Phenylendiamine and Propargylic Alcohols via a Domino Gold-Catalyzed Hydroamination/Cyclization Process.
abstract: The gold-catalyzed reaction of o-phenylendiamine with propargylic alcohols affords 1,5-benzodiazepines bearing different substituents on the 2 and 4 positions. The method allows even for the selective preparation of 4-substituted 1,5-benzodiazepine derivatives.
authors.affiliation: Dipartimento di Chimica e Tecnologie del Farmaco, La Sapienza, Università di Roma , P.le A. Moro 5, 00185 Rome, Italy.
authors.forename: Sandro
authors.initials: S
authors.lastname: Cacchi
authors.affiliation: Dipartimento di Chimica e Tecnologie del Farmaco, La Sapienza, Università di Roma , P.le A. Moro 5, 00185 Rome, Italy.
authors.forename: Giancarlo
authors.initials: G
authors.lastname: Fabrizi
authors.affiliation: Dipartimento di Chimica e Tecnologie del Farmaco, La Sapienza, Università di Roma , P.le A. Moro 5, 00185 Rome, Italy.
authors.forename: Antonella
authors.initials: A
authors.lastname: Goggiamani
authors.affiliation: Dipartimento di Chimica e Tecnologie del Farmaco, La Sapienza, Università di Roma , P.le A. Moro 5, 00185 Rome, Italy.
authors.forename: Antonia
authors.initials: A
authors.lastname: Iazzetti