title: DC vaccine generated by ALA-PDT-induced immunogenic apoptotic cells for skin squamous cell carcinoma.
abstract: Dendritic cell (DC) vaccines were generated by apoptotic squamous cell carcinoma (SCC) cells induced by 5-aminolevulinic acid (ALA)-mediated photodynamic therapy (PDT). ALA-PDT-DC vaccine inhibited the growth of SCC in mice, indicating that immunogenic apoptotic cells can activate an effective antitumor adaptive immunity and lead to a DC vaccine-based cancer immunotherapy.
authors.affiliation: Department of Photomedicine, Shanghai Skin Disease Hospital , Shanghai, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Ji
authors.affiliation: Department of Photomedicine, Shanghai Skin Disease Hospital , Shanghai, China.
authors.forename: Yunfeng
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Department of Photomedicine, Shanghai Skin Disease Hospital, Shanghai, China; Biophotonics Research Laboratory, Center for Interdisciplinary Biomedical Education and Research, University of Central Oklahoma, Edmond, OK, USA.
authors.forename: Wei R
authors.initials: WR
authors.lastname: Chen
authors.affiliation: Department of Photomedicine, Shanghai Skin Disease Hospital , Shanghai, China.
authors.forename: Xiuli
authors.initials: X
authors.lastname: Wang
keywords: Dendritic cells; PDT-DC vaccine; immunogenic apoptotic cells; photodynamic therapy; squamous cell carcinoma