title: Area under curve of temporal estradiol measurements for prediction of the detrimental effect of estrogen exposure on implantation.
abstract: OBJECTIVE
  To assess whether the area under the curve of temporal estradiol measurements (AUCEM) during cycles of assisted reproductive technology (ART) can be used to predict failure of implantation and clinical pregnancy.
  
  
  METHODS
  In a prospective study, women aged 24-39years undergoing ART at a center in Turkey were enrolled between January and December 2014. Eligible patients had a regular menstrual cycle, normal levels of serum prolactin, and no hormone treatment within the past 3months. The area under the curve of the time course of estradiol measurements was calculated for each participant, and assessed for its ability to predict successful implantation.
  
  
  RESULTS
  Among 282 participants, 109 (38.6%) women had successful implantation. There was a significant difference between the two groups of women in AUCEM, estradiol per day (AUCEM divided by duration of stimulation), and endometrial thickness on the day of human chorionic gonadotropin administration (P<0.05 for all).
  
  
  CONCLUSIONS
  The area under the curve of estradiol measurements during ART cycles might be useful for predicting failure of implantation and clinical pregnancy.
authors.affiliation: Department of Obstetrics and Gynecology, Zeynep Kamil Training and Research Hospital, Istanbul, Turkey.
authors.forename: Tayfun
authors.initials: T
authors.lastname: Kutlu
authors.affiliation: Department of Obstetrics and Gynecology, Zeynep Kamil Training and Research Hospital, Istanbul, Turkey. Electronic address: enozkaya1979@gmail.com.
authors.forename: Enis
authors.initials: E
authors.lastname: Ozkaya
authors.affiliation: Department of Obstetrics and Gynecology, Zeynep Kamil Training and Research Hospital, Istanbul, Turkey.
authors.forename: Habibe
authors.initials: H
authors.lastname: Ayvaci
authors.affiliation: Department of Obstetrics and Gynecology, Zeynep Kamil Training and Research Hospital, Istanbul, Turkey.
authors.forename: Belgin
authors.initials: B
authors.lastname: Devranoglu
authors.affiliation: Department of Obstetrics and Gynecology, Zeynep Kamil Training and Research Hospital, Istanbul, Turkey.
authors.forename: Ilhan
authors.initials: I
authors.lastname: Sanverdi
authors.affiliation: Department of Obstetrics and Gynecology, Zeynep Kamil Training and Research Hospital, Istanbul, Turkey.
authors.forename: Yavuz
authors.initials: Y
authors.lastname: Sahin
authors.affiliation: Department of Obstetrics and Gynecology, Zeynep Kamil Training and Research Hospital, Istanbul, Turkey.
authors.forename: Taylan
authors.initials: T
authors.lastname: Senol
authors.affiliation: Department of Obstetrics and Gynecology, Zeynep Kamil Training and Research Hospital, Istanbul, Turkey.
authors.forename: Ates
authors.initials: A
authors.lastname: Karateke
mesh_terms: D000328:Adult; D019540:Area Under Curve; D006063:Chorionic Gonadotropin / Q000008:administration & dosage*; D010064:Embryo Implantation; D004717:Endometrium / Q000378:metabolism; D004958:Estradiol / Q000097:blood*; D005260:Female; D005640:Follicle Stimulating Hormone / Q000008:administration & dosage*; D006801:Humans; D008597:Menstrual Cycle / Q000187:drug effects; D015999:Multivariate Analysis; D011247:Pregnancy; D011446:Prospective Studies; D012372:ROC Curve; D012044:Regression Analysis; D012102:Reproductive Control Agents / Q000008:administration & dosage*; D020554:Sperm Injections, Intracytoplasmic; D014421:Turkey; D055815:Young Adult
chemical_list: D006063:Chorionic Gonadotropin; D012102:Reproductive Control Agents; D004958:Estradiol; D005640:Follicle Stimulating Hormone
keywords: Area under the curve of estradiol measurements; Assisted reproductive technology; Clinical pregnancy; Freeze-all policy; Implantation