title: PURTSCHER RETINOPATHY AS A MANIFESTATION OF HEMOPHAGOCYTIC LYMPHOHISTIOCYTOSIS.
abstract: OBJECTIVE
  The authors describe a woman diagnosed with hemophagocytic lymphohistiocytosis and found to have retinal examination findings consistent with Purtscher retinopathy.
  
  
  METHODS
  A 52-year-old woman underwent multimodal imaging, including color fundus photography and spectral-domain optical coherence tomography, to confirm the diagnosis.
  
  
  RESULTS
  The ophthalmic examination and imaging confirmed the findings of Purtscher retinopathy with significant inner retinal thickening on spectral-domain optical coherence tomography. Throughout a hospital course complicated by multi-organ failure, she continued to have profoundly limited visual acuity, likely resulting from inner retinal ischemia affecting the posterior pole of both eyes.
  
  
  CONCLUSIONS
  The authors describe a patient with hemophagocytic lymphohistiocytosis, a disease characterized by disruption of normal natural killer cell activity with subsequent uncontrolled cytokine release, who presented with Purtscher retinopathy confirmed with spectral-domain optical coherence tomography.
authors.affiliation: *Department of Ophthalmology, Edward S. Harkness Eye Institute, Columbia University College of Physicians and Surgeons, New York, New York; †Vitreous Retina Macular Consultants of New York, New York, New York; and ‡LuEsther T. Mertz Retinal Research Center, Manhattan Eye, Ear, and Throat Institute, New York, New York.
authors.forename: Dov B
authors.initials: DB
authors.lastname: Sebrow
authors.forename: Elona
authors.initials: E
authors.lastname: Dhrami-Gavazi
authors.forename: Jason D
authors.initials: JD
authors.lastname: Horowitz
authors.forename: Lawrence A
authors.initials: LA
authors.lastname: Yannuzzi
mesh_terms: D005260:Female; D006801:Humans; D007511:Ischemia / Q000209:etiology; D051359:Lymphohistiocytosis, Hemophagocytic / Q000150:complications*; D008875:Middle Aged; D012164:Retinal Diseases / Q000209:etiology*