title: Predictors of community-associated Staphylococcus aureus, methicillin-resistant and methicillin-susceptible Staphylococcus aureus skin and soft tissue infections in primary-care settings.
abstract: Skin and soft tissue infections (SSTIs) due to Staphylococcus aureus have become increasingly common in the outpatient setting; however, risk factors for differentiating methicillin-resistant S. aureus (MRSA) and methicillin-susceptible S. aureus (MSSA) SSTIs are needed to better inform antibiotic treatment decisions. We performed a case-case-control study within 14 primary-care clinics in South Texas from 2007 to 2015. Overall, 325 patients [S. aureus SSTI cases (case group 1, n = 175); MRSA SSTI cases (case group 2, n = 115); MSSA SSTI cases (case group 3, n = 60); uninfected control group (control, n = 150)] were evaluated. Each case group was compared to the control group, and then qualitatively contrasted to identify unique risk factors associated with S. aureus, MRSA, and MSSA SSTIs. Overall, prior SSTIs [adjusted odds ratio (aOR) 7·60, 95% confidence interval (CI) 3·31-17·45], male gender (aOR 1·74, 95% CI 1·06-2·85), and absence of healthcare occupation status (aOR 0·14, 95% CI 0·03-0·68) were independently associated with S. aureus SSTIs. The only unique risk factor for community-associated (CA)-MRSA SSTIs was a high body weight (⩾110 kg) (aOR 2·03, 95% CI 1·01-4·09).
authors.affiliation: College of Pharmacy, The University of Texas at Austin,Austin, TX,USA.
authors.forename: G C
authors.initials: GC
authors.lastname: Lee
authors.affiliation: Texas Tech University Health Sciences Center,School of Pharmacy,Dallas, TX,USA.
authors.forename: R G
authors.initials: RG
authors.lastname: Hall
authors.affiliation: College of Pharmacy, The University of Texas at Austin,Austin, TX,USA.
authors.forename: N K
authors.initials: NK
authors.lastname: Boyd
authors.affiliation: Department of Clinical Laboratory Sciences,School of Health Professions,University of Texas Health Science Center,San Antonio, TX,USA.
authors.forename: S D
authors.initials: SD
authors.lastname: Dallas
authors.affiliation: South Texas Ambulatory Research Network, The University of Texas Health Science Center,San Antonio, TX,USA.
authors.forename: L C
authors.initials: LC
authors.lastname: Du
authors.affiliation: South Texas Ambulatory Research Network, The University of Texas Health Science Center,San Antonio, TX,USA.
authors.forename: L B
authors.initials: LB
authors.lastname: Treviño
authors.affiliation: South Texas Ambulatory Research Network, The University of Texas Health Science Center,San Antonio, TX,USA.
authors.forename: C
authors.initials: C
authors.lastname: Retzloff
authors.affiliation: South Texas Ambulatory Research Network, The University of Texas Health Science Center,San Antonio, TX,USA.
authors.forename: S B
authors.initials: SB
authors.lastname: Treviño
authors.affiliation: College of Pharmacy, The University of Texas at Austin,Austin, TX,USA.
authors.forename: K A
authors.initials: KA
authors.lastname: Lawson
authors.affiliation: College of Pharmacy, The University of Texas at Austin,Austin, TX,USA.
authors.forename: J P
authors.initials: JP
authors.lastname: Wilson
authors.affiliation: Department of Clinical Pathology and Genomic Medicine,Methodist Research Institute,Houston, TX,USA.
authors.forename: R J
authors.initials: RJ
authors.lastname: Olsen
authors.affiliation: Department of Biology,The University of Texas San Antonio,San Antonio, TX,USA.
authors.forename: Y
authors.initials: Y
authors.lastname: Wang
authors.affiliation: College of Pharmacy, The University of Texas at Austin,Austin, TX,USA.
authors.forename: C R
authors.initials: CR
authors.lastname: Frei
mesh_terms: D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D017714:Community-Acquired Infections / Q000453:epidemiology* / Q000382:microbiology; D005260:Female; D006801:Humans; D008297:Male; D055624:Methicillin-Resistant Staphylococcus aureus / Q000502:physiology; D008875:Middle Aged; D011320:Primary Health Care; D012307:Risk Factors; D018461:Soft Tissue Infections / Q000453:epidemiology* / Q000382:microbiology; D013203:Staphylococcal Infections / Q000453:epidemiology* / Q000382:microbiology; D013207:Staphylococcal Skin Infections / Q000453:epidemiology / Q000382:microbiology; D013211:Staphylococcus aureus / Q000502:physiology*; D013781:Texas / Q000453:epidemiology; D055815:Young Adult
keywords: 
                 Staphylococcus aureus
              ; Epidemiology; soft tissue infections