title: [Cytokine profile in young children with acute stenotic laryngotracheitis].
abstract: BACKGROUND
  One of the most severe complications of acute respiratory infections in young children is acute stenotic laryngotracheitis (croup). The relationship between cytokine blood levels and symptoms of croup, croup severity, disease sequel, despite numerous studies is still unclear.
  
  
  OBJECTIVE
  Cytokine profile in young children with acute stenotic laryngotracheitis investigation.
  
  
  METHODS
  112 children aged 12 min. - 36 mon. with acute stenotic laryngotracheitis which were treated at the Lviv Regional Infectious Diseases Hospital were kept under observation. Croup symptoms, levels of interleukins (IL1, IL4, IL6, IL10, IL17) in serum, DNA and RNA viruses in respiratory nasal mucus were studied; Chan croup severity was used.
  
  
  RESULTS
  In the pathogenesis of croup has an important role the imbalance between inflammatory (IL1, IL6) and anti-inflammatory (IL4, IL10, IL17) cytokines, which does not reduce the intensity of inflammatory reactions and its lead to local swelling, muscle spasm, excessive production of mucus in the place of viral replication. The levels of inflammatory and anti-inflammatory cytokines in the blood serum of children with croup were significantly higher than in patients with acute laryngitis. In patients with recurrent croup, unlike patients with the first case of croup does we don't see a significant correlation between the concentrations of inflammatory and anti-inflammatory cytokine levels Conclusions: The significantly higher levels of cytokines in children with croup compared with the group of patients with acute laryngitis were found, imbalance between anti-inflammatory (IL1, IL6) cytokine levels and inflammatory (IL4, IL10, IL17) cytokine levels in children who developed recurrent croup.
authors.affiliation: ЛЬВІВСЬКИЙ НАЦІОНАЛЬНИЙ МЕДИЧНИЙ УНІВЕРСИТЕТ ІМЕНІ ДАНИЛА ГАЛИЦЬКОГО, вул. Героїв Майдану 14 кв.4 м. Львів, Україна, Tel: +380967775377 hladchenko.olya@gmail.com.
authors.forename: Ольга І
authors.initials: ОІ
authors.lastname: Гладченко
authors.affiliation: ЛЬВІВСЬКИЙ НАЦІОНАЛЬНИЙ МЕДИЧНИЙ УНІВЕРСИТЕТ ІМЕНІ ДАНИЛА ГАЛИЦЬКОГО, ЛЬВІВ, УКРАЇНА
authors.forename: Павло В
authors.initials: ПВ
authors.lastname: Токарєв
authors.affiliation: ЛЬВІВСЬКИЙ НАЦІОНАЛЬНИЙ МЕДИЧНИЙ УНІВЕРСИТЕТ ІМЕНІ ДАНИЛА ГАЛИЦЬКОГО, ЛЬВІВ, УКРАЇНА
authors.forename: Олександр Б
authors.initials: ОБ
authors.lastname: Надрага
mesh_terms: D000208:Acute Disease; D002675:Child, Preschool; D003440:Croup / Q000276:immunology*; D016207:Cytokines / Q000378:metabolism*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007249:Inflammation; D007827:Laryngitis / Q000276:immunology*; D014136:Tracheitis / Q000276:immunology*
chemical_list: D016207:Cytokines
keywords: acute stenotic laryngotracheitis; children; croup; cytokines