title: Near Full-Length Genomic Characterization of a Novel HIV-1 Unique Recombinant (CRF55_01B/CRF07_BC) from a Malaysian Immigrant Worker in Zhejiang, China.
abstract: Recombinant forms contribute substantially to the genetic diversity of human immunodeficiency virus type 1 (HIV-1). Here we report a novel HIV-1 recombinant detected from a comprehensive HIV-1 molecular epidemiologic study among cross-border populations in China. Near full-length genome (NFLG) phylogenetic analysis showed that the novel HIV-1 recombinant ZJCIQ15005, which was isolated from a Malaysian immigrant worker in Zhejiang, China, clustered with CRF55_01B reference sequences but set up a distinct branch. Recombinant analysis showed that the NFLG of ZJCIQ15005 composed of CRF55_01B (as the backbone) and CRF07_BC, with 12 recombinant break points observed in the pol, vif, vpr, tat, rev, env, nef, and 3'LTR regions. This is the first detection of a novel HIV-1 recombinant (CRF55_01B/CRF07_BC) in immigrant workers in China. The emergence of this recombinant may increase the complexity of the HIV-1 epidemic in China and suggests the importance of continuous surveillance of the dynamic changes of HIV-1.
authors.affiliation: 1 Zhuhai International Travel Healthcare Center , Zhuhai, China .
authors.forename: Haibo
authors.initials: H
authors.lastname: Wang
authors.affiliation: 2 Zhejiang International Travel Healthcare Center , Hangzhou, China .
authors.forename: Peng
authors.initials: P
authors.lastname: Luo
authors.affiliation: 3 Beijing International Travel Healthcare Center , Beijing, China .
authors.forename: Hong
authors.initials: H
authors.lastname: Zhu
authors.affiliation: 4 Yunnan International Travel Healthcare Center , Kunming, China .
authors.forename: Ningli
authors.initials: N
authors.lastname: Wang
authors.affiliation: 5 State Key Laboratory for Infectious Disease Prevention and Control, National Center for AIDS/STD Control and Prevention, Chinese Center for Disease Control and Prevention , Beijing, China .
authors.forename: Jing
authors.initials: J
authors.lastname: Hu
authors.affiliation: 1 Zhuhai International Travel Healthcare Center , Zhuhai, China .
authors.forename: Qiuhua
authors.initials: Q
authors.lastname: Mo
authors.affiliation: 1 Zhuhai International Travel Healthcare Center , Zhuhai, China .
authors.forename: Ze
authors.initials: Z
authors.lastname: Yang
authors.affiliation: 5 State Key Laboratory for Infectious Disease Prevention and Control, National Center for AIDS/STD Control and Prevention, Chinese Center for Disease Control and Prevention , Beijing, China .
authors.forename: Yi
authors.initials: Y
authors.lastname: Feng
mesh_terms: D000328:Adult; D002681:China; D016000:Cluster Analysis; D054242:Emigrants and Immigrants; D019143:Evolution, Molecular; D016679:Genome, Viral; D015658:HIV Infections / Q000821:virology*; D015497:HIV-1 / Q000145:classification* / Q000235:genetics* / Q000302:isolation & purification; D006801:Humans; D008297:Male; D010802:Phylogeny; D011995:Recombination, Genetic; D017422:Sequence Analysis, DNA
keywords: China; HIV; URF; recombinant