title: Cytogenetic Findings and Survival in B-cell Chronic Lymphocytic Leukemia. Second IWCCLL Compilation of Data on 662 Patients.
abstract: Chromosome analysis on CLL-cells from 649 patients revealed clonal changes in 311 cases (48%). The most common abnormalities were trisomy 12 (n = 112), and structural changes on the long arm of chromosome 13 (n = 62), most of them interstitial deletions or translocations involving 13q14, the site of the retinoblastoma gene. Complex karyotypes were associated with poor prognosis, although karyotypic changes rarely develop during the course of the disease. Among patients with single chromosomal abnormalities those with trisomy 12 had a poor survival, whereas those with structural changes on chromosome 13 had as good a prognosis as patients with a normal karyotype.
authors.forename: G
authors.initials: G
authors.lastname: Juliusson
authors.forename: D
authors.initials: D
authors.lastname: Oscier
authors.forename: G
authors.initials: G
authors.lastname: Juliusson
authors.forename: G
authors.initials: G
authors.lastname: Gahrton
authors.forename: D
authors.initials: D
authors.lastname: Oscier
authors.forename: M
authors.initials: M
authors.lastname: Fitchett
authors.forename: F
authors.initials: F
authors.lastname: Ross
authors.forename: V
authors.initials: V
authors.lastname: Brito-Babapulle
authors.forename: D
authors.initials: D
authors.lastname: Catovsky
authors.forename: S
authors.initials: S
authors.lastname: Knuutila
authors.forename: E
authors.initials: E
authors.lastname: Elonen
authors.forename: M
authors.initials: M
authors.lastname: Lechleitner
authors.forename: J
authors.initials: J
authors.lastname: Tanzer
authors.forename: M
authors.initials: M
authors.lastname: Schoenwald
authors.forename: G L
authors.initials: GL
authors.lastname: Castoldi
authors.forename: A
authors.initials: A
authors.lastname: Cuneo
authors.forename: P
authors.initials: P
authors.lastname: Nowell
authors.forename: L
authors.initials: L
authors.lastname: Peterson
authors.forename: N
authors.initials: N
authors.lastname: Kay
keywords: CLL; Cytogenetic findings; survival