title: Sucrose and KF quenching system for solution phase parallel synthesis.
abstract: The KF, sucrose (table sugar) exploited as quenching system in solution phase parallel synthesis. Excess of electrophiles were covalently trapped with hydroxyl functionality of sucrose and due to polar nature of sucrose derivative was solubilize in water. Potassium fluoride used to convert various excess electrophilic reagents such as acid chlorides, sulfonyl chlorides, isocyanates to corresponding fluorides, which are less susceptible for hydrolysis and subsequently sucrose traps these fluorides and dissolves them in water thus removing them from reaction mixture. Various excess electrophilic reagents such as acid chlorides, sulfonyl chlorides, and isocyanates were quenched successfully to give pure products in excellent yields.
authors.affiliation: Department of Chemistry, K. T. H. M. College (Affiliated to Savitribai Phule Pune University), Gangapur Road, Nashik, Pune, 422002 India.
authors.forename: Sunil
authors.initials: S
authors.lastname: Chavan
authors.affiliation: Department of Chemistry, K. T. H. M. College (Affiliated to Savitribai Phule Pune University), Gangapur Road, Nashik, Pune, 422002 India.
authors.forename: Rahul
authors.initials: R
authors.lastname: Watpade
authors.affiliation: Department of Chemistry, K. T. H. M. College (Affiliated to Savitribai Phule Pune University), Gangapur Road, Nashik, Pune, 422002 India.
authors.forename: Raghunath
authors.initials: R
authors.lastname: Toche
keywords: Acid chlorides; Isocyanates; KF; Parallel synthesis; Sucrose; Sulfonyl chlorides