title: Modulation of Irisin and Physical Activity on Executive Functions in Obesity and Morbid obesity.
abstract: Whether the executive profile is different between obesity (OB) and morbid obesity (MO) remains unclear. Recent evidence suggests that physical activity (PA) can act as a cognitive enhancer. Irisin is a recently discovered hormone associated with some of the positive effects of PA. The objective of the study was to investigate the executive profile in OB and MO, and to explore the role of PA and irisin. 114 participants were included (21 OB, 44 MO and 49 healthy controls-HC) in the study and assessed with the Wisconsin Card Sorting Test, Stroop Color and Word Test, and Iowa Gambling Task. All participants were female, aged between 18 and 60 years. Results showed a similar dysfunctional profile on decision making in OB and MO compared with HC. Thus, no specific neuropsychological profiles between OB and MO can be clearly observed in our sample. However, a negative correlation was found between irisin and executive functioning. These results demonstrate a specific executive profile in OB and a relevant and negative modulation of irisin on executive functioning. Although irisin might be a promising target for the treatment of obesity, its effects on cognition might be considered when thinking about its therapeutic use.
authors.affiliation: Department of Psychiatry, University Hospital of Bellvitge-IDIBELL, Barcelona, Spain.|CIBER Fisiopatología Obesidad y Nutrición (CIBERObn), Instituto Salud Carlos III, Spain.
authors.forename: A B
authors.initials: AB
authors.lastname: Fagundo
authors.affiliation: Department of Psychiatry, University Hospital of Bellvitge-IDIBELL, Barcelona, Spain.|CIBER Fisiopatología Obesidad y Nutrición (CIBERObn), Instituto Salud Carlos III, Spain.|Department of Clinical Sciences, School of Medicine, University of Barcelona, Spain.
authors.forename: S
authors.initials: S
authors.lastname: Jiménez-Murcia
authors.affiliation: Department of Psychiatry, University Hospital of Bellvitge-IDIBELL, Barcelona, Spain.|CIBER Fisiopatología Obesidad y Nutrición (CIBERObn), Instituto Salud Carlos III, Spain.
authors.forename: C
authors.initials: C
authors.lastname: Giner-Bartolomé
authors.affiliation: Department of Psychiatry, University Hospital of Bellvitge-IDIBELL, Barcelona, Spain.|CIBER Fisiopatología Obesidad y Nutrición (CIBERObn), Instituto Salud Carlos III, Spain.
authors.forename: Z
authors.initials: Z
authors.lastname: Agüera
authors.affiliation: Department of Psychiatry, University Hospital of Bellvitge-IDIBELL, Barcelona, Spain.|CIBER Fisiopatología Obesidad y Nutrición (CIBERObn), Instituto Salud Carlos III, Spain.
authors.forename: S
authors.initials: S
authors.lastname: Sauchelli
authors.affiliation: CIBER Fisiopatología Obesidad y Nutrición (CIBERObn), Instituto Salud Carlos III, Spain.|Endocrine Division, Complejo Hospitalario U. de Santiago, Santiago de Compostela University, Spain.
authors.forename: M
authors.initials: M
authors.lastname: Pardo
authors.affiliation: CIBER Fisiopatología Obesidad y Nutrición (CIBERObn), Instituto Salud Carlos III, Spain.|Endocrine Division, Complejo Hospitalario U. de Santiago, Santiago de Compostela University, Spain.
authors.forename: A B
authors.initials: AB
authors.lastname: Crujeiras
authors.affiliation: CIBER Fisiopatología Obesidad y Nutrición (CIBERObn), Instituto Salud Carlos III, Spain.|Departament de Psicobiologia i Metodologia, Universitat Autònoma de Barcelona, Spain.
authors.forename: R
authors.initials: R
authors.lastname: Granero
authors.affiliation: CIBER Fisiopatología Obesidad y Nutrición (CIBERObn), Instituto Salud Carlos III, Spain.|Department of Pyschological, Personality, Evaluation and Treatment of the University of Valencia, Spain.
authors.forename: R
authors.initials: R
authors.lastname: Baños
authors.affiliation: CIBER Fisiopatología Obesidad y Nutrición (CIBERObn), Instituto Salud Carlos III, Spain.|Department of Basic Psychology, Clinic and Psychobiology of the University Jaume I, Castellón, Spain.
authors.forename: C
authors.initials: C
authors.lastname: Botella
authors.affiliation: CIBER Fisiopatología Obesidad y Nutrición (CIBERObn), Instituto Salud Carlos III, Spain.|Human Pharmacology and Clinical Neurosciences Research Group, Neuroscience Research Program, IMIM-Hospital del Mar Research Institute, Parc de Salut Mar, Barcelona, Spain.
authors.forename: R
authors.initials: R
authors.lastname: de la Torre
authors.affiliation: CIBER Fisiopatología Obesidad y Nutrición (CIBERObn), Instituto Salud Carlos III, Spain.|Service of Diabetes, Endocrinology and Nutrition, Institut d'Investigació Biomèdica de Girona (IdlBGi) Hospital Dr Josep Trueta, Girona, Spain.
authors.forename: J M
authors.initials: JM
authors.lastname: Fernández-Real
authors.affiliation: CIBER Fisiopatología Obesidad y Nutrición (CIBERObn), Instituto Salud Carlos III, Spain.|Service of Diabetes, Endocrinology and Nutrition, Hospital Clínico Universitario Virgen de Victoria, Málaga, Spain.
authors.forename: J C
authors.initials: JC
authors.lastname: Fernández-García
authors.affiliation: CIBER Fisiopatología Obesidad y Nutrición (CIBERObn), Instituto Salud Carlos III, Spain.|Department of Endocrinology and Nutrition, University of Navarra, Pamplona, Spain.
authors.forename: G
authors.initials: G
authors.lastname: Frühbeck
authors.affiliation: CIBER Fisiopatología Obesidad y Nutrición (CIBERObn), Instituto Salud Carlos III, Spain.|Department of Endocrinology and Nutrition, University of Navarra, Pamplona, Spain.
authors.forename: A
authors.initials: A
authors.lastname: Rodríguez
authors.affiliation: Department of Psychiatry, University Hospital of Bellvitge-IDIBELL, Barcelona, Spain.|CIBER Fisiopatología Obesidad y Nutrición (CIBERObn), Instituto Salud Carlos III, Spain.
authors.forename: N
authors.initials: N
authors.lastname: Mallorquí-Bagué
authors.affiliation: Departament de Psicobiologia i Metodologia, Universitat Autònoma de Barcelona, Spain.
authors.forename: S
authors.initials: S
authors.lastname: Tárrega
authors.affiliation: CIBER Fisiopatología Obesidad y Nutrición (CIBERObn), Instituto Salud Carlos III, Spain.|Service of Diabetes, Endocrinology and Nutrition, Hospital Clínico Universitario Virgen de Victoria, Málaga, Spain.
authors.forename: F J
authors.initials: FJ
authors.lastname: Tinahones
authors.affiliation: Service of Diabetes, Endocrinology and Nutrition, Institut d'Investigació Biomèdica de Girona (IdlBGi) Hospital Dr Josep Trueta, Girona, Spain.
authors.forename: R
authors.initials: R
authors.lastname: Rodriguez
authors.affiliation: CIBER Fisiopatología Obesidad y Nutrición (CIBERObn), Instituto Salud Carlos III, Spain.|Service of Diabetes, Endocrinology and Nutrition, Institut d'Investigació Biomèdica de Girona (IdlBGi) Hospital Dr Josep Trueta, Girona, Spain.
authors.forename: F
authors.initials: F
authors.lastname: Ortega
authors.affiliation: Department of Psychiatry, University Hospital of Bellvitge-IDIBELL, Barcelona, Spain.|Department of Clinical Sciences, School of Medicine, University of Barcelona, Spain.|CIBER Salud Mental (CIBERSAM), Instituto Salud Carlos III, Spain.
authors.forename: J M
authors.initials: JM
authors.lastname: Menchón
authors.affiliation: CIBER Fisiopatología Obesidad y Nutrición (CIBERObn), Instituto Salud Carlos III, Spain.|Endocrine Division, Complejo Hospitalario U. de Santiago, Santiago de Compostela University, Spain.
authors.forename: F F
authors.initials: FF
authors.lastname: Casanueva
authors.affiliation: Department of Psychiatry, University Hospital of Bellvitge-IDIBELL, Barcelona, Spain.|CIBER Fisiopatología Obesidad y Nutrición (CIBERObn), Instituto Salud Carlos III, Spain.|Department of Clinical Sciences, School of Medicine, University of Barcelona, Spain.
authors.forename: F
authors.initials: F
authors.lastname: Fernández-Aranda
mesh_terms: D000293:Adolescent; D000328:Adult; D003657:Decision Making; D015444:Exercise; D005260:Female; D005353:Fibronectins / Q000378:metabolism*; D006801:Humans; D008875:Middle Aged; D009767:Obesity, Morbid / Q000378:metabolism / Q000503:physiopathology / Q000523:psychology
chemical_list: C577593:FNDC5 protein, human; D005353:Fibronectins