title: Reduced local diffusion homogeneity as a biomarker for temporal lobe epilepsy.
abstract: In the present study, we adopted a novel method-local diffusion homogeneity (LDH)-to characterize the structure feature in mesial temporal lobe epilepsy (MTLE). Diffusion-weighted images were acquired from 11 left MTLE patients, 16 right MTLE patients, and 20 healthy controls from May 2014 to January 2015. Local diffusion homogeneity was compared among patient groups and controls by 2 sample t test. The discriminative value of LDH abnormalities was examined by receiver operating characteristic (ROC) curve analysis. Correlations with disease duration and onset age in both patient groups were assessed using Pearson's coefficient. Both patient groups exhibited lower LDH in the anterior corpus callosum (P < 0.05, corrected), and this regional anomaly exhibited excellent classification performance in left MTLE patients (sensitivity = 82%, specificity = 100%), right MTLE patients (sensitivity = 81%, specificity = 90%), and the entire patient cohort (sensitivity = 82%, specificity = 95%). In summary, left and right MTLE patients show common pathological changes in the anterior corpus callosum. This regional LDH abnormality is a potential quantitative biomarker for MTLE.
authors.affiliation: Department of Neurology, the First Affiliated Hospital of Guangxi Medical University, Nanning Department of Neurology, the Nanxishan Hospital of Guangxi Zhuang Autonomous Region, Guilin Department of Radiology, the First Affiliated Hospital of Guangxi Medical University, Nanning, China.
authors.forename: Hui-Hua
authors.initials: HH
authors.lastname: Liu
authors.forename: Jun
authors.initials: J
authors.lastname: Wang
authors.forename: Xue-Mei
authors.initials: XM
authors.lastname: Chen
authors.forename: Jian-Ping
authors.initials: JP
authors.lastname: Li
authors.forename: Wei
authors.initials: W
authors.lastname: Ye
authors.forename: Jinou
authors.initials: J
authors.lastname: Zheng
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D003337:Corpus Callosum / Q000473:pathology*; D038524:Diffusion Magnetic Resonance Imaging; D004833:Epilepsy, Temporal Lobe / Q000473:pathology*; D005260:Female; D006801:Humans; D008297:Male; D011446:Prospective Studies; D012372:ROC Curve; D012680:Sensitivity and Specificity