title: Obesity and Intestinal Tumorigenesis in Adult Min/+ Mice from Early-life High-fat Diet Exposure Were Not Inherited Transgenerationally.
abstract: OBJECTIVE
  Exposure to 45% fat diet in utero and during nursing increased body weight and small intestinal tumor numbers in adult F1 multiple intestinal neoplasia (Min/+) mice, implicating that early-life obesogenic conditions predispose for obesity and intestinal tumorigenesis later in life. In this study, it was examined whether these effects were transferred to the next two generations.
  
  
  RESULTS
  In F2 mice, exposed to the obesogenic diet as germ cells within the embryonic F1 mice, there were no consistent differences in body weight, blood glucose levels or small intestinal tumor numbers whether their mother or father, both, or no parents were exposed to 45% vs. 10% fat diet. In F3 mice, never exposed to obesogenic diet, no differences were found in any end-points, whether both grandparents were exposed to 45% or 10% fat, or not.
  
  
  CONCLUSIONS
  The effects of early-life high-fat diet on adult obesity and intestinal tumorigenesis were not inherited transgenera-tionally.
authors.affiliation: Department of Toxicology and Risk Assessment, Domain for Infection Control and Environmental Health, Norwegian Institute of Public Health, Oslo, Norway inger-lise.steffensen@fhi.no.
authors.forename: Inger-Lise
authors.initials: IL
authors.lastname: Steffensen
mesh_terms: D000818:Animals; D001786:Blood Glucose; D001835:Body Weight; D063646:Carcinogenesis / Q000235:genetics*; D059305:Diet, High-Fat / Q000009:adverse effects; D006801:Humans; D007414:Intestinal Neoplasms / Q000235:genetics* / Q000473:pathology; D051379:Mice; D008822:Mice, Transgenic; D009765:Obesity / Q000235:genetics* / Q000473:pathology
chemical_list: D001786:Blood Glucose
keywords: Body weight; Min mouse; high-fat diet; intestinal tumorigenesis; obesity; transgenerational