title: THE ROLE OF CYSTEINE PROTEASE IN ALZHEIMER DISEASE.
abstract: BACKGROUND
  Cysteine protease are biological catalysts which play a pivotal role in numerous biological reactions in organism. Much of the literature is inscribed to their biochemical significance, distribution and mechanism of action. Many diseases, e.g. Alzheimer's disease, develop due to enzyme balance disruption. Understanding of cysteine protease's disbalance is therefor a key to unravel the new possibilities of treatment. Cysteine protease are one of the most important enzymes for protein disruption during programmed cell death. Whether protein disruption is part of cell deaths is not enough clear in any cases. Thereafter, any tissue disruption, including proteolysis, generate more or less inflammation appearance.
  
  
  METHODS
  This review briefly summarizes the current knowledge about pathological mechanism's that results in AD, with significant reference to the role of cysteine protease in it. Based on the summary, new pharmacological approach and development of novel potent drugs with selective toxicity targeting cysteine protease will be a major challenge in years to come.
authors.affiliation: Department of Biochemistry, Faculty of Pharmacy, University of Tuzla, Tuzla, Bosnia and Herzegovina.
authors.forename: Samra
authors.initials: S
authors.lastname: Hasanbasic
authors.affiliation: Department of Clinical Pharmacy, Faculty of Pharmacy, University of Tuzla, Tuzla, Bosnia and Herzegovina.
authors.forename: Alma
authors.initials: A
authors.lastname: Jahic
authors.affiliation: Berlin- Chemie Menarini, Representative Office in Sarajevo, Bosnia and Herzegovina.
authors.forename: Emina
authors.initials: E
authors.lastname: Karahmet
authors.affiliation: Pharmacy Pharmacom, Tuzla, Bosnia and Herzegovina.
authors.forename: Asja
authors.initials: A
authors.lastname: Sejranic
authors.affiliation: General Hospital Tesanj, Bosnia and Herzegovina; Department of Pathophysiology, Faculty of Pharmacy, Sarajevo, Bosnia and Herzegovina.
authors.forename: Besim
authors.initials: B
authors.lastname: Prnjavorac
keywords: Alzheimer’s disease; calpain; caspase; cathepsin; cystatin C; cysteine protease; inflammation