title: Evaluation of oxidant, antioxidant, and S100B levels in patients with conversion disorder.
abstract: BACKGROUND
  Various psychodynamic, neurobiological, genetic, and sociocultural factors are believed to be involved in the etiology of conversion disorder (CD). Oxidative metabolism has been shown to deteriorate in association with many health problems and psychiatric disorders. We evaluated oxidative metabolism and S100B levels in the context of this multifactorial disease.
  
  
  METHODS
  Thirty-seven patients with CD (25 females and 12 males) and 42 healthy volunteers (21 females and 21 males), all matched for age and sex, were included in this study. The total oxidant status, total antioxidant status, oxidative stress index, and S100B levels were compared between the two groups.
  
  
  RESULTS
  The total oxidant status, oxidative stress index, and S100B levels were significantly higher in patients with CD than in the control group, whereas the total antioxidant status was significantly lower.
  
  
  CONCLUSIONS
  CD is associated with deterioration of oxidative metabolism and increased neuronal damage.
authors.affiliation: Department of Emergency Medicine, Faculty of Medicine, Harran University.
authors.forename: Hasan
authors.initials: H
authors.lastname: Büyükaslan
authors.affiliation: Department of Psychiatry, Balıklıgöl State Hospital.
authors.forename: Sultan Basmacı
authors.initials: SB
authors.lastname: Kandemir
authors.affiliation: Department of Psychiatry, Faculty of Medicine, Harran University, Sanliurfa.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Asoğlu
authors.affiliation: Bursa Yüksek Ihtisas Training and Research Hospital, Bursa.
authors.forename: Halil
authors.initials: H
authors.lastname: Kaya
authors.affiliation: Department of Emergency Medicine, Faculty of Medicine, Harran University.
authors.forename: Mehmet Tahir
authors.initials: MT
authors.lastname: Gökdemir
authors.affiliation: Department of Psychiatry, Faculty of Medicine, Harran University, Sanliurfa.
authors.forename: İbrahim Fatih
authors.initials: İF
authors.lastname: Karababa
authors.affiliation: Department of Emergency Medicine, Mehmet Akif İnan Research Hospital.
authors.forename: Fatih
authors.initials: F
authors.lastname: Güngörmez
authors.affiliation: Department of Child and Adolescent Psychiatry.
authors.forename: Fethiye
authors.initials: F
authors.lastname: Kılıçaslan
authors.affiliation: Department of Biochemistry, Faculty of Medicine, Harran University, Sanliurfa, Turkey.
authors.forename: Emin
authors.initials: E
authors.lastname: Şavik
keywords: S100B; conversion disorder; oxidative stress