title: A H(+)-triggered bubble-generating nanosystem for killing cancer cells.
abstract: We constructed a H(+)-triggered bubble-generating nanosystem (BGNS), which generated CO2 bubbles in the acidic environment of lysosomes after being internalized by cancer cells. The quickly generated bubbles caused enhanced lysosomal membrane permeabilization. As expected, H(+)-triggered BGNS possessed remarkable cytotoxicity against MCF-7 breast cancer cells, and successfully overcame the multidrug resistance of MCF-7/ADR cells.
authors.affiliation: Key Laboratory on Luminescent and Real-Time Analytical Chemistry (Southwest University), College of Chemistry and Chemical Engineering, Southwest University, Beibei, Chongqing 400715, China. zhenghz@swu.edu.cn.
authors.forename: Lili
authors.initials: L
authors.lastname: Yang
authors.forename: Zuhuang
authors.initials: Z
authors.lastname: Wen
authors.forename: Yijuan
authors.initials: Y
authors.lastname: Long
authors.forename: Ning
authors.initials: N
authors.lastname: Huang
authors.forename: Yuan
authors.initials: Y
authors.lastname: Cheng
authors.forename: Li
authors.initials: L
authors.lastname: Zhao
authors.forename: Huzhi
authors.initials: H
authors.lastname: Zheng
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000378:metabolism / Q000633:toxicity; D002245:Carbon Dioxide / Q000737:chemistry; D002470:Cell Survival / Q000187:drug effects; D004317:Doxorubicin / Q000737:chemistry / Q000378:metabolism / Q000633:toxicity; D019008:Drug Resistance, Neoplasm / Q000187:drug effects; D005740:Gases / Q000737:chemistry*; D006801:Humans; D006859:Hydrogen / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D008247:Lysosomes / Q000378:metabolism; D061986:MCF-7 Cells; D018613:Microscopy, Confocal; D036103:Nanotechnology / Q000379:methods*
chemical_list: D000970:Antineoplastic Agents; D005740:Gases; D002245:Carbon Dioxide; D006859:Hydrogen; D004317:Doxorubicin