title: The evolving role of adiponectin as an additive biomarker in HFrEF.
abstract: Heart failure (HF) is a growing health problem. Despite improved management and outcome, the number of patients with HF is expected to keep rising in the following years. In recent research, adiponectin was shown to exert beneficial effects in the cardiovascular system, but the protein was also implicated in the development and progression of HF. The objective of this review is to provide an overview of current knowledge on the role of adiponectin in HF with reduced ejection fraction. We discuss the cardioprotective and (anti-) inflammatory actions of adiponectin and its potential use in clinical diagnosis and prognosis.
authors.affiliation: Laboratory for Cellular and Molecular Cardiology, Department of Cardiology, Antwerp University Hospital, Edegem, Belgium. tahnee.sente@uantwerpen.be.|Cardiovascular Diseases, Department of Translational Pathophysiological Research, University of Antwerp, Universiteitsplein 1, 2610, Antwerp, Belgium. tahnee.sente@uantwerpen.be.
authors.forename: Tahnee
authors.initials: T
authors.lastname: Sente
authors.affiliation: Laboratory for Cellular and Molecular Cardiology, Department of Cardiology, Antwerp University Hospital, Edegem, Belgium.|Cardiovascular Diseases, Department of Translational Pathophysiological Research, University of Antwerp, Universiteitsplein 1, 2610, Antwerp, Belgium.
authors.forename: Andreas
authors.initials: A
authors.lastname: Gevaert
authors.affiliation: Cardiovascular Diseases, Department of Translational Pathophysiological Research, University of Antwerp, Universiteitsplein 1, 2610, Antwerp, Belgium.
authors.forename: An
authors.initials: A
authors.lastname: Van Berendoncks
authors.affiliation: Laboratory for Cellular and Molecular Cardiology, Department of Cardiology, Antwerp University Hospital, Edegem, Belgium.|Cardiovascular Diseases, Department of Translational Pathophysiological Research, University of Antwerp, Universiteitsplein 1, 2610, Antwerp, Belgium.
authors.forename: Christiaan J
authors.initials: CJ
authors.lastname: Vrints
authors.affiliation: Laboratory for Cellular and Molecular Cardiology, Department of Cardiology, Antwerp University Hospital, Edegem, Belgium.|Cardiovascular Diseases, Department of Translational Pathophysiological Research, University of Antwerp, Universiteitsplein 1, 2610, Antwerp, Belgium.
authors.forename: Vicky Y
authors.initials: VY
authors.lastname: Hoymans
mesh_terms: D052242:Adiponectin / Q000097:blood* / Q000502:physiology; D015415:Biomarkers / Q000097:blood; D002908:Chronic Disease; D018450:Disease Progression; D006333:Heart Failure / Q000097:blood* / Q000503:physiopathology*; D006801:Humans; D011379:Prognosis; D012307:Risk Factors; D013318:Stroke Volume
chemical_list: D052242:Adiponectin; D015415:Biomarkers
keywords: Adiponectin; Biomarker; Cardioprotection; Heart failure; Inflammation