title: Assessment of the Influence of Meal Type on Fluoride Absorption due to Ingestion of professionally Applied Gels.
abstract: OBJECTIVE
  The aim of this study is to assess the influence of eating, prior to application of professionally used gels, on the rate of fluoride absorption due to the ingestion of 1.23% acidulated phosphate fluoride (APF).
  
  
  METHODS
  After fasting for 12 hours, 16 adult volunteers (> 65 kg) ingested two types of meal: Breakfast (n = 8) and Lunch (n = 8). Accidental ingestion of fluoride gel used in molding trays was simulated (12,300 ppm; 61.5 mg F; pH = 4.65) 15 minutes after eating. After ingestion of the fluoride solution, 3 mL of venous blood were collected at the following times: Zero (before ingestion) and 15, 30, 45 minutes, 1, 2, and 3 hours. Fluoride concentrations in blood plasma were determined using an ion selective electrode.
  
  
  RESULTS
  With the exception of time 0 (p > 0.05), the average blood plasma concentration of the breakfast group (BG) (0.34 ± 0.04 mg/L) was higher than that of the lunch group (LG) (0.24 ± 0.03 mg/L), with the moment of peak concentration being 2 hours after ingestion for both groups (BG = 0.4 mg/L; LG = 0.28 mg/L).
  
  
  CONCLUSIONS
  Results reinforce the idea that eating before undergoing professional application of fluoride is a factor of extreme importance regarding its safety, and that the time following a patient's heaviest meal should be the time of choice for planning clinical care.
  
  
  CONCLUSIONS
  Our results should be considered when planning collective action that involves the application of the gel on children in a school environment, thus ensuring the procedure's safety.
authors.affiliation: Department of Public Health, Sao Leopoldo Mandic School of Dentistry and Research Center, Campinas, Sao Paulo Brazil.
authors.forename: Andreany M
authors.initials: AM
authors.lastname: Cavalli
authors.affiliation: Department of Public Health, Sao Leopoldo Mandic School of Dentistry and Research Center, Campinas, Sao Paulo Brazil.
authors.forename: Adriana G
authors.initials: AG
authors.lastname: Rebouças
authors.affiliation: Department of Public Health, Jundiai Medical School, Area of Public Health, Jundiai, Center University Herminio Ometto de Araras, School of Dentistry, Araras, Sao Paulo, Brazil.
authors.forename: Luciane
authors.initials: L
authors.lastname: Zanin
authors.affiliation: Professor, Department of Public Health, Sao Leopoldo Mandic School of Dentistry and Research Center, Campinas, Sao Paulo Brazil, Phone: +19999087533, e-mail: flaviaflorio@yahoo.com.
authors.forename: Flávia M
authors.initials: FM
authors.lastname: Flório
mesh_terms: D000149:Acidulated Phosphate Fluoride / Q000008:administration & dosage* / Q000493:pharmacokinetics*; D000328:Adult; D002327:Cariostatic Agents / Q000008:administration & dosage* / Q000493:pharmacokinetics*; D004435:Eating; D005460:Fluorides, Topical / Q000008:administration & dosage* / Q000493:pharmacokinetics*; D005782:Gels; D064368:Healthy Volunteers; D006801:Humans; D006863:Hydrogen-Ion Concentration
chemical_list: D002327:Cariostatic Agents; D005460:Fluorides, Topical; D005782:Gels; D000149:Acidulated Phosphate Fluoride
keywords: Children; Clinical trial; Fluoride; Safety; Topical fluoride gel.