title: Concepts in regenerative medicine: Past, present, and future in articular cartilage treatment.
abstract: Regenerative medicine is emerging with great interest and hope from patients, industry, academia, and medical professionals. Cartilage regeneration, restoration, or repair is one of the prime targets that remains largely unsolved, and many believe that regenerative medicine can possibly deliver solutions that can be widely used to address the current gap(s) in treatment. In the United States, Europe, Australia, and India the regulation of regenerative based treatments has become a big debate. Although the rules and regulations remain unclear, clinicians that are interested should carry-on with the best available guidelines to ensure safety and compliance during delivery in clinical practice to avoid regulatory infraction. Many have made significant investment of time, resources, and facilities in recent years to provide new regenerative treatment options and advance medical care for patients. Instead of reinventing the wheel, it would be more efficient to adopt currently accepted standards and nomenclature borrowed from transplantation science, and cord blood storage industries. The purposes of this article are to provide some historical background to the field of regenerative medicine as it applies to cartilage, and how this field has developed. This will be followed by a separate discussion on regulatory oversight and input and how it has influenced access to care. Furthermore, we discuss current clinical techniques and progress, and ways to deliver these treatments to patients safely, effectively, and in a cost sensitive manner, concluding with an overview of some of the promising regenerative techniques specific to cartilage.
authors.affiliation: Andrews Research & Education Institute, Gulf Breeze, FL, USA.
authors.forename: Adam W
authors.initials: AW
authors.lastname: Anz
authors.affiliation: Infohealth FZE, Dubai, United Arab Emirates.
authors.forename: Asawari
authors.initials: A
authors.lastname: Bapat
authors.affiliation: Dr. Humeira Badsha Medical Center, Dubai, United Arab Emirates; Orthopaedics, Rehabilitation, and Podiatry Department, Ft. Belvoir Community Hospital, Ft. Belvoir, VA, USA.
authors.forename: William D
authors.initials: WD
authors.lastname: Murrell
keywords: Cartilage; Clinical techniques; Mesenchymal stem cells; Regenerative medicine; Regulatory rules for clinical practice