title: Analysis of Human Papillomavirus Infection in 16,320 Patients From a Gynecology Clinic in Central South China.
abstract: OBJECTIVE
  This study aimed to investigate the relationship between persistent human papillomavirus (HPV) infection and cervical lesion.
  
  
  METHODS
  Clinical data of 16,320 patients who visited our clinic between January 2009 and December 2013 were collected. Retrospective analysis was performed to analyze the overall HPV infection and compare the infection rates of different subtypes among different age groups, to reveal the relationship between persistent HPV infection and cervical cytology.
  
  
  RESULTS
  The overall prevalence of HPV was 26.54%. The most common genotypes were HPV 52, HPV 16, HPV 58, CP8304, and HPV 53. The highest overall high-risk HPV prevalence was found in women older than 60 years, and the lowest prevalence was found in women between the ages of 30 and 39 years. There was no significant difference in low-risk HPV prevalence among different age groups (p = .693). The HPV clearance rate after 1 year among those with initial positive test was 87.65%. The constituent ratios of high- or low-risk HPV subtypes were not significantly different (p = .545) between nonpersistent-positive and persistent-positive (PP) groups. Conversely, the constituent ratios of singe- or multi-type HPV infection were significantly different (p < .05) between these 2 groups. The most common subtypes in PP group were HPV 16, 52, 58, CP8304, and 33. The occurrence rates of atypical squamous cells of undetermined significance, high-grade squamous intraepithelial lesion, and squamous cell carcinoma in the PP group significantly increased (p < .05).
  
  
  CONCLUSIONS
  Persistent HPV infections are mainly caused by multiple types of HPV and high-risk HPV. Our region should particularly pay attention to the prevention and treatment of HPV 16, 52, and 58.
authors.affiliation: Department of 1Gynecology and Obstetrics, the Third Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China; and 2Department of Gynecologic Oncology, Hunan Cancer Hospital and The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Hunan, People's Republic of China.
authors.forename: Song S
authors.initials: SS
authors.lastname: Xiao
authors.forename: Jie L
authors.initials: JL
authors.lastname: Fan
authors.forename: Si L
authors.initials: SL
authors.lastname: He
authors.forename: Yue R
authors.initials: YR
authors.lastname: Li
authors.forename: Lu Y
authors.initials: LY
authors.lastname: Wang
authors.forename: Ke N
authors.initials: KN
authors.lastname: Yu
authors.forename: Xin L
authors.initials: XL
authors.lastname: Deng
authors.forename: Min
authors.initials: M
authors.lastname: Xue
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D065309:Atypical Squamous Cells of the Cervix; D002294:Carcinoma, Squamous Cell / Q000453:epidemiology*; D002681:China / Q000453:epidemiology; D005260:Female; D005838:Genotype; D006801:Humans; D008875:Middle Aged; D027383:Papillomaviridae / Q000145:classification / Q000235:genetics / Q000302:isolation & purification*; D030361:Papillomavirus Infections / Q000150:complications / Q000453:epidemiology* / Q000821:virology*; D015995:Prevalence; D012189:Retrospective Studies; D012307:Risk Factors; D065310:Squamous Intraepithelial Lesions of the Cervix / Q000453:epidemiology*; D055815:Young Adult