title: Synthesis and antifungal activity of dehydroabietic acid-based 1,3,4-thiadiazole-thiazolidinone compounds.
abstract: In an attempt to search for new natural products-based antifungal agents, a series of novel dehydroabietic acid derivatives bearing a 1,3,4-thiadiazole-thiazolidinone moiety were designed and synthesized. The primary bioassay used showed that at a concentration of [Formula: see text], the target compounds 3c, 3f, and 3n exhibited excellent antifungal activity (91.3 % inhibition) against Gibberella zeae, which was equivalent to the commercial antifungal drug azoxystrobin (positive control).
authors.affiliation: School of Chemistry and Chemical Engineering, Guangxi University, Nanning, 530004, Guangxi, People's Republic of China.
authors.forename: Naiyuan
authors.initials: N
authors.lastname: Chen
authors.affiliation: School of Chemistry and Chemical Engineering, Guangxi University, Nanning, 530004, Guangxi, People's Republic of China. wgduan@gxu.edu.cn.
authors.forename: Wengui
authors.initials: W
authors.lastname: Duan
authors.affiliation: School of Chemistry and Chemical Engineering, Guangxi University, Nanning, 530004, Guangxi, People's Republic of China.
authors.forename: Guishan
authors.initials: G
authors.lastname: Lin
authors.affiliation: School of Chemistry and Chemical Engineering, Guangxi University, Nanning, 530004, Guangxi, People's Republic of China.
authors.forename: Luzhi
authors.initials: L
authors.lastname: Liu
authors.affiliation: School of Chemistry and Chemical Engineering, Guangxi University, Nanning, 530004, Guangxi, People's Republic of China.
authors.forename: Rui
authors.initials: R
authors.lastname: Zhang
authors.affiliation: Guangxi Key Laboratory of Functional Phytochemicals Research and Utilization, Guangxi Institute of Botany, Guangxi Zhuang Autonomous Region and Chinese Academy of Sciences, Guilin, 541006, Guangxi, People's Republic of China.
authors.forename: Dianpeng
authors.initials: D
authors.lastname: Li
mesh_terms: D045784:Abietanes / Q000737:chemistry*; D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D005658:Fungi / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D013830:Thiadiazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D045784:Abietanes; D000935:Antifungal Agents; D013830:Thiadiazoles; C013913:dehydroabietic acid
keywords: Activity; Antifungal; Dehydroabietic acid; Natural product; Thiadiazole; Thiazolidinone