title: The SAATELLITE and EVADE Clinical Studies Within the COMBACTE Consortium: A Public-Private Collaborative Effort in Designing and Performing Clinical Trials for Novel Antibacterial Drugs to Prevent Nosocomial Pneumonia.
abstract: The Innovative Medicines Initiative-funded COMBACTE consortium fosters academic-industry partnership in pioneering studies to combat serious bacterial infections. We describe how this partnership is advancing the development of 2 monoclonal antibodies, MEDI4893 and MEDI3902, for the prevention of nosocomial pneumonia.
authors.affiliation: INSERM CIC 1435, INSERM UMR 1092 and Service de Réanimation Polyvalente, CHU Dupuytren, Limoges.
authors.forename: Bruno
authors.initials: B
authors.lastname: François
authors.affiliation: Service de Réanimation Médicale, Institute of Cardiometabolism and Nutrition, Groupe Hospitalier Pitié-Salpêtrière, Assistance Publique-Hôpitaux de Paris, Université Pierre et Marie Curie-Paris 6, France.
authors.forename: Jean
authors.initials: J
authors.lastname: Chastre
authors.affiliation: Service de Médecine Intensive Adulte et Centre des Brûlés, Département des Centres Interdisciplinaire et Logistique Médicale, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland.
authors.forename: Philippe
authors.initials: P
authors.lastname: Eggiman
authors.affiliation: Service des Soins Intensifs, Cliniques Universitaires St Luc, Université Catholique de Louvain, Bruxelles, Belgium.
authors.forename: Pierre-François
authors.initials: PF
authors.lastname: Laterre
authors.affiliation: Servei de Pneumologia, Hospital Clinic, Universitat de Barcelona, IDIBAPS CIBERES.
authors.forename: Antoni
authors.initials: A
authors.lastname: Torres
authors.affiliation: Servicio de Medicina Intensiva, Hospital Clínico San Carlos, Madrid, Spain.
authors.forename: Miguel
authors.initials: M
authors.lastname: Sanchez
authors.affiliation: MedImmune, One MedImmune Way, Gaithersburg, Maryland.
authors.forename: Mark T
authors.initials: MT
authors.lastname: Esser
authors.affiliation: MedImmune, One MedImmune Way, Gaithersburg, Maryland.
authors.forename: Brian
authors.initials: B
authors.lastname: Bishop
authors.affiliation: Department of Medical Microbiology and Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, The Netherlands.
authors.forename: Marc
authors.initials: M
authors.lastname: Bonten
authors.affiliation: Laboratory of Medical Microbiology, VAXINFECTIO, University of Antwerp, Belgium.
authors.forename: Herman
authors.initials: H
authors.lastname: Goosens
authors.affiliation: MedImmune, One MedImmune Way, Gaithersburg, Maryland.
authors.forename: Hasan S
authors.initials: HS
authors.lastname: Jafri
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D000911:Antibodies, Monoclonal / Q000627:therapeutic use*; D003428:Cross Infection / Q000517:prevention & control*; D055808:Drug Discovery; D006801:Humans; D018410:Pneumonia, Bacterial / Q000517:prevention & control*; D053717:Pneumonia, Ventilator-Associated / Q000517:prevention & control; D055818:Public-Private Sector Partnerships; D014481:United States
chemical_list: D000900:Anti-Bacterial Agents; D000911:Antibodies, Monoclonal
keywords: ICU; monoclonal antibody; nosocomial pneumonia; ventilator-associated pneumonia