title: Microvillus inclusion disease: a subtotal enterectomy as a bridge to transplantation.
abstract: BACKGROUND
  Microvillus inclusion disease (MVID) is a known congenital cause of intractable diarrhea resulting in permanent intestinal failure. There is need for a lifelong total parenteral nutrition (TPN) from diagnosis and the prognosis is poor. Most patients die by the second decade of life as a result of complications of parenteral alimentation including liver failure or sepsis. The only available treatment at this moment is a small bowel transplantation. But before that moment, the patients often suffer from a persistent failure to thrive and electrolyte disturbances despite continuous TPN.
  
  
  RESULTS
  We report what we believe is a first case of an extensive small bowel resection in a 5-month-old boy with proven MVID to act as a bridge to (liver-) intestinal transplantation to treat failure to thrive and intractable diarrhea.
  
  
  CONCLUSIONS
  An extensive small bowel resection can be done to enhance the chance of survival leading up to the transplantation by managing fluid and electrolyte imbalance. It facilitates medical management of these patients and makes a bowel transplantation possible at a later stage.
authors.affiliation: a Department of Gastroenterology, Hepatology and Nutrition , University Hospital Gasthuisberg , Leuven , Belgium.
authors.forename: Karen
authors.initials: K
authors.lastname: van Hoeve
authors.affiliation: a Department of Gastroenterology, Hepatology and Nutrition , University Hospital Gasthuisberg , Leuven , Belgium.
authors.forename: Ilse
authors.initials: I
authors.lastname: Hoffman
authors.affiliation: b Fabio Fusaro MD Neonatal Surgery Unit , Bambino Gesù Children's and Research Hospital , Rome , Italy.
authors.forename: Fabio
authors.initials: F
authors.lastname: Fusaro
authors.affiliation: c Department of Transplantation , University Hospital Gasthuisberg , Leuven , Belgium.
authors.forename: Jacques
authors.initials: J
authors.lastname: Pirenne
authors.affiliation: d Department Pediatrics and Neonatology , GZA St-Augustinus Hospital Antwerp , Wilrijk , Belgium.
authors.forename: Ann
authors.initials: A
authors.lastname: Vander Auwera
authors.affiliation: d Department Pediatrics and Neonatology , GZA St-Augustinus Hospital Antwerp , Wilrijk , Belgium.
authors.forename: Anne-Marie
authors.initials: AM
authors.lastname: Dieltjens
authors.affiliation: e Department of Pathology , University Hospital Gasthuisberg , Leuven , Belgium.
authors.forename: Gert
authors.initials: G
authors.lastname: De Hertogh
authors.affiliation: c Department of Transplantation , University Hospital Gasthuisberg , Leuven , Belgium.
authors.forename: Diethard
authors.initials: D
authors.lastname: Monbaliu
authors.affiliation: f Department of Abdominal Surgery , University Hospital Gasthuisberg , Leuven , Belgium.
authors.forename: Marc
authors.initials: M
authors.lastname: Miserez
mesh_terms: D001706:Biopsy; D013505:Digestive System Surgical Procedures / Q000379:methods*; D005500:Follow-Up Studies; D006801:Humans; D007231:Infant, Newborn; D007422:Intestines / Q000000981:diagnostic imaging / Q000601:surgery*; D008286:Malabsorption Syndromes / Q000175:diagnosis / Q000601:surgery*; D008297:Male; D008871:Microvilli / Q000473:pathology*; D009081:Mucolipidoses / Q000175:diagnosis / Q000601:surgery*; D016377:Organ Transplantation; D013997:Time Factors
keywords: Failure to thrive; microvillus inclusion disease; small bowel resection; transplantation