title: DIABETES ALTERS THE MAGNITUDE OF VITREOMACULAR ADHESION.
abstract: OBJECTIVE
  To quantify the changes in vitreomacular interactions that occur with aging in diabetic eyes in comparison with age-matched control eyes.
  
  
  METHODS
  Spectral-domain optical coherence tomography (Spectralis; Heidelberg Engineering) foveal scans of diabetic patients, without evidence of cystoid macular edema, were included. Twenty-five raster foveal scans were performed on every subject. Area of vitreomacular adhesion was delineated using the Spectralis drawing tool and calculated in square millimeter. Data collected included gender, race, best-corrected visual acuity, and posterior vitreous detachment status. Subjects were divided into age groups according to decade of life.
  
  
  RESULTS
  Spectral-domain optical coherence tomography scans from 141 diabetic patients were analyzed. Area of vitreomacular adhesion (mm) showed a hyperbolic decline in diabetic patients (35.5 ± 0, 35.0 ± 3, 34.0 ± 3, 33.9 ± 5, 33.7 ± 6, 29.0 ± 11, 23 ± 15, 13 ± 15). With aging, incidence of posterior vitreous detachment increased and incidence of complete attachment decreased.
  
  
  CONCLUSIONS
  Diabetes affects the magnitude of attachment of the vitreous gel to the macula that results in stronger and longer lasting attachment of the gel throughout life. Gender differences were not noticed in diabetic patients, suggesting that vitreomacular adhesion remains robust in both genders in diabetes despite aging.
authors.affiliation: *New York Eye and Ear Infirmary of Mount Sinai, New York, New York; †Department of Ophthalmology, University of Louisville School of Medicine, Louisville, Kentucky; ‡duPont Manual High School, Louisville, Kentucky; and §Department of Ophthalmology and Visual Sciences, University of Massachusetts School of Medicine, Worcester, Massachusetts.
authors.forename: Brooke Lw
authors.initials: BL
authors.lastname: Nesmith
authors.forename: Agustina C
authors.initials: AC
authors.lastname: Palacio
authors.forename: Yam
authors.initials: Y
authors.lastname: Schaal
authors.forename: Akash
authors.initials: A
authors.lastname: Gupta
authors.forename: Shlomit
authors.initials: S
authors.lastname: Schaal
mesh_terms: D000328:Adult; D017677:Age Distribution; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000502:physiology*; D016022:Case-Control Studies; D003920:Diabetes Mellitus; D003930:Diabetic Retinopathy / Q000473:pathology* / Q000503:physiopathology; D005260:Female; D005858:Germany / Q000453:epidemiology; D006801:Humans; D015994:Incidence; D008266:Macula Lutea / Q000473:pathology* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D000267:Tissue Adhesions / Q000473:pathology* / Q000503:physiopathology; D041623:Tomography, Optical Coherence; D014822:Vitreous Body / Q000473:pathology* / Q000503:physiopathology; D020255:Vitreous Detachment / Q000453:epidemiology / Q000473:pathology*; D055815:Young Adult