title: Effects of Food Thickeners on the Inhibitory Effect of Voglibose Oral-disintegrating Tablets on Post-prandial Elevation of Blood Sugar Levels.
abstract: The aim of this study was to examine the effects of food thickeners on the pharmacodynamics of voglibose, an α-glucosidase inhibitor. The pharmacodynamics of voglibose were examined in an open-label study in 9 healthy participants after the ingestion of a single oral dose of a voglibose oral-disintegrating tablet, with and without food thickener immersion. The area under the incremental blood sugar concentration-time curve was larger and the rate of increments in the blood sugar concentration was higher with the voglibose oral-disintegrating tablets immersed in the food thickener than with the tablets that were not immersed. Immersing the voglibose oral-disintegrating tablets in the food thickener possibly delayed their disintegration rate. This suggests that commercially available food thickeners may be associated with changes in the disintegration of voglibose oral-disintegrating tablets and should therefore be used carefully in certain clinical situations.
authors.affiliation: Department of Pharmacy, Hospital Bando.
authors.forename: Takashi
authors.initials: T
authors.lastname: Tomita
authors.forename: Hidekazu
authors.initials: H
authors.lastname: Goto
authors.forename: Kenji
authors.initials: K
authors.lastname: Sumiya
authors.forename: Tadashi
authors.initials: T
authors.lastname: Yoshida
authors.forename: Katsuya
authors.initials: K
authors.lastname: Tanaka
authors.forename: Yukinao
authors.initials: Y
authors.lastname: Kohda
mesh_terms: D000284:Administration, Oral; D000328:Adult; D001786:Blood Glucose / Q000378:metabolism*; D055598:Chemical Phenomena; D005260:Female; D005503:Food Additives / Q000494:pharmacology*; D065089:Glycoside Hydrolase Inhibitors / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000494:pharmacology; D006801:Humans; D007004:Hypoglycemic Agents / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000494:pharmacology; D007294:Inositol / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000493:pharmacokinetics / Q000494:pharmacology; D008297:Male; D008875:Middle Aged; D019518:Postprandial Period; D012995:Solubility; D013607:Tablets
chemical_list: D001786:Blood Glucose; D005503:Food Additives; D065089:Glycoside Hydrolase Inhibitors; D007004:Hypoglycemic Agents; D013607:Tablets; D007294:Inositol; C102817:voglibose