title: Comparison of two diagnostic techniques, skin-prick test and component resolved diagnosis in the follow-up of a cohort of paediatric patients with pollinosis. Multicentre pilot study in a highly exposed allergenic area.
abstract: BACKGROUND
  Over the last years, different works have been published about the importance of incorporating new diagnosis techniques in allergic patients such as component-resolved diagnosis (CRD). The objective of this study is to compare the evolution of allergic sensitisation profiles by means of CRD and cutaneous tests (SPT) on pollen-allergic patients.
  
  
  METHODS
  A total of 123 patients aged between 2 and 14 years were included in an open, prospective, multicentre study. All the children had symptoms suggestive of seasonal respiratory allergic disease, with the diagnosis confirmed by cutaneous tests. Specific-IgE to major pollen-allergens (CRD) and SPT were performed at basal and after three years of follow-up.
  
  
  RESULTS
  Out of 123 patients included, a total of 85 were analysed. The mean age was 8±3 years. Significant changes in the allergic sensitisation profiles were observed for the most prevalent allergens (Olea and grass) but it is in grass, the most relevant allergen in terms of allergen pressure, where changes in both absolute and relative frequencies between SPT and CRD were more evident.
  
  
  CONCLUSIONS
  CRD seems to be an essential tool to carry out an appropriate follow-up of patients with allergic respiratory disease, as well as to decide on the immunotherapy composition that best matches the allergic sensitisation profile of patients.
authors.affiliation: Hospital Universitario de Fuenlabrada, Madrid, Spain.
authors.forename: E
authors.initials: E
authors.lastname: González-Mancebo
authors.affiliation: Allergy Department, Institute for Health Research (IDiPAZ), Hospital Universitario La Paz, Madrid, Spain.
authors.forename: J
authors.initials: J
authors.lastname: Domínguez-Ortega
authors.affiliation: Hospital Universitario Infanta Elena de Valdemoro, Madrid, Spain.
authors.forename: S
authors.initials: S
authors.lastname: Blanco-Bermejo
authors.affiliation: Hospital Infanta Cristina de Parla, Madrid, Spain.
authors.forename: E
authors.initials: E
authors.lastname: González-Seco
authors.affiliation: Hospital del Tajo de Aranjuez, Madrid, Spain.
authors.forename: M J
authors.initials: MJ
authors.lastname: Trujillo
authors.affiliation: ALK-Abelló, S.A. Madrid, Spain. Electronic address: fernando.delatorremartinez@alk.net.
authors.forename: F
authors.initials: F
authors.lastname: de la Torre
mesh_terms: D000293:Adolescent; D000485:Allergens / Q000276:immunology*; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D004781:Environmental Exposure / Q000009:adverse effects; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007114:Immunization; D007073:Immunoglobulin E / Q000097:blood; D008297:Male; D031658:Olea / Q000276:immunology; D010865:Pilot Projects; D011058:Pollen / Q000276:immunology*; D006255:Rhinitis, Allergic, Seasonal / Q000175:diagnosis*; D012621:Seasons; D012882:Skin Tests
chemical_list: D000485:Allergens; D007073:Immunoglobulin E
keywords: Allergic respiratory disease; Childhood; Component-resolved diagnosis; Pollinosis; Polysensitisation