title: Celiac disease in children and adolescents with Hashimoto Thyroiditis.
abstract: OBJECTIVE
  The aim of this study was to evaluate clinical and laboratory findings and determine the prevalence of celiac disease (CD) in children with Hashimoto thyroiditis (HT).
  
  
  METHODS
  The data of a total of 80 patients with positive anti-thyroid antibodies who were aged between 6 and 17.9 years were retrospectively studied. Age, gender, complaints at the time of presentation, family history of thyroid disorders, clinical and laboratory findings were recorded. The levels of thyrotropin, free thyroxin, thyroid autoantibodies (thyroid peroxidase and thyroglobulin antibodies), immunoglobulin A (IgA), anti-tissue transglutaminase antibodies (IgA-tTG), and thyroid ultrasonography findings were enrolled.
  
  
  RESULTS
  Eighty patients (65 females (81.2%) and 15 males (18,8%)) were included in the study. Family history of thyroid disease was present in 38 (47.5%) patients. The most common complaints at the time of presentation were goiter (%30) and weight gain (%25). Forty three (53.8%), 23 (28.7%), and 14 (17.5%) patients presented with euthyroidism, subclinical hypothyroidism and obvious hypothyroidism. Thirty seven (46.2%) patients had goiter. IgA-tTG was found to be positive after a diagnosis of HT was made in only one patient (1.25%) and the diagnosis of CD was confirmed when intestinal biopsy of this patient revealed villus atrophy, crypt hyperplasia and increase in the intraepithelial lymphocyte count.
  
  
  CONCLUSIONS
  In our study, it was found that the most common complaints at presentation in patients with a diagnosis of hashimoto thyroiditis included goiter, weakness and weight gain and the prevalence of celiac diseases was found to be 1.25% (1/80). This study shows that the prevalence of CD in patients with a diagnosis of HT is higher compared to the prevalence in the healthy pediatric population.
authors.affiliation: Division of Pediatric Endocrinology, Dokuz Eylül University School of Medicine, İzmir, Turkey.
authors.forename: Hale
authors.initials: H
authors.lastname: Tuhan
authors.affiliation: Division of Pediatric Allergy and Immunology, Dokuz Eylül University School of Medicine, İzmir, Turkey.
authors.forename: Sakine
authors.initials: S
authors.lastname: Işık
authors.affiliation: Division of Pediatric Endocrinology, Dokuz Eylül University School of Medicine, İzmir, Turkey.
authors.forename: Ayhan
authors.initials: A
authors.lastname: Abacı
authors.affiliation: Division of Pediatric Endocrinology, Dokuz Eylül University School of Medicine, İzmir, Turkey.
authors.forename: Erdem
authors.initials: E
authors.lastname: Şimşek
authors.affiliation: Division of Pediatric Endocrinology, Dokuz Eylül University School of Medicine, İzmir, Turkey.
authors.forename: Ahmet
authors.initials: A
authors.lastname: Anık
authors.affiliation: Division of Pediatric Allergy and Immunology, Dokuz Eylül University School of Medicine, İzmir, Turkey.
authors.forename: Özden
authors.initials: Ö
authors.lastname: Anal
authors.affiliation: Division of Pediatric Endocrinology, Dokuz Eylül University School of Medicine, İzmir, Turkey.
authors.forename: Ece
authors.initials: E
authors.lastname: Böber
keywords: Celiac disease; children; hashimoto thyroiditis