title: Aspirin use and bleeding volume in skin cancer patients undergoing surgery: a randomized controlled trial.
abstract: ᅟ: We investigated the occurrence of bleeding complications in patients who underwent skin tumor surgery and compared it between Aspirin users and a placebo control group. In this double blind randomized controlled trial, 32 patients who continued taking aspirin (intervention group) and 38 patients who stopped taking Aspirin (placebo group) before surgery were compared in terms of intraoprative and postoperative bleeding problems, hematoma and local signs of coagulopathy. There was no statistically significant difference in intraoprative bleeding between the study groups (P = 0.107). We concluded that continuation of Aspirin therapy had no significant effect on bleeding complications in patients who underwent skin tumor surgery.
  
  
  BACKGROUND
  IRCT201602049768N5 Flow chart of the study process and its final finding.
authors.affiliation: Department of Plastic Surgery, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Arman
authors.initials: A
authors.lastname: Engheta
authors.affiliation: Department of Plastic Surgery, Razi Hospital, Tehran University of Medical Sciences, Vahdat Eslami st, Tehran, Iran. H_abianeh@yahoo.com.
authors.forename: Shahryar
authors.initials: S
authors.lastname: Hadadi Abianeh
authors.affiliation: Department of Plastic Surgery, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Ali
authors.initials: A
authors.lastname: Atri
authors.affiliation: Department of Anesthesiology, Razi Hospital, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Mehdi
authors.initials: M
authors.lastname: Sanatkarfar
mesh_terms: D000368:Aged; D000925:Anticoagulants / Q000627:therapeutic use*; D001241:Aspirin / Q000627:therapeutic use*; D004311:Double-Blind Method; D005260:Female; D006470:Hemorrhage / Q000139:chemically induced*; D006801:Humans; D007431:Intraoperative Complications / Q000139:chemically induced; D008297:Male; D008875:Middle Aged; D010975:Platelet Aggregation Inhibitors / Q000627:therapeutic use*; D011183:Postoperative Complications / Q000139:chemically induced; D012878:Skin Neoplasms / Q000601:surgery*
chemical_list: D000925:Anticoagulants; D010975:Platelet Aggregation Inhibitors; D001241:Aspirin
keywords: Acetyl salicylic acid; Aspirin; Bleeding; Complication; Skin cancer; Surgery