title: Copper-Catalyzed N-Arylation of 2-Pyridones Employing Diaryliodonium Salts at Room Temperature.
abstract: A new and mild synthetic approach for the N-arylation of 2-pyridones with diaryliodonium salts has been developed. Most reactions proceed readily at room temperature in the presence of 10 mol % of copper chloride. As a result, a wide range of N-arylpyridine-2-ones were synthesized in yields of 23% to 99%. With this method, an antifibrotic drug, Pirfenidone, was successfully synthesized in 99% yield within 30 min at room temperature.
authors.affiliation: Department of Chemistry and Nano Science, Ewha Womans University , Seoul 120-750, South Korea.
authors.forename: Seo-Hee
authors.initials: SH
authors.lastname: Jung
authors.affiliation: Department of Chemistry and Nano Science, Ewha Womans University , Seoul 120-750, South Korea.
authors.forename: Dan-Bi
authors.initials: DB
authors.lastname: Sung
authors.affiliation: Department of Chemistry and Nano Science, Ewha Womans University , Seoul 120-750, South Korea.
authors.forename: Cho-Hee
authors.initials: CH
authors.lastname: Park
authors.affiliation: Department of Chemistry and Nano Science, Ewha Womans University , Seoul 120-750, South Korea.
authors.forename: Won-Suk
authors.initials: WS
authors.lastname: Kim
mesh_terms: D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D015394:Molecular Structure; D009861:Onium Compounds / Q000737:chemistry*; D011728:Pyridones / Q000737:chemistry*; D012492:Salts / Q000737:chemistry; D013057:Spectrum Analysis / Q000379:methods; D013237:Stereoisomerism; D013696:Temperature
chemical_list: D009861:Onium Compounds; D011728:Pyridones; D012492:Salts; D003300:Copper