title: Translocation (14;19)(q32;q13.1) in a Young Patient who Developed a Large Cell Lymphoma after an Initial Diagnosis of CLL.
abstract: A translocation (14;19)(q32;q13.1) was found in a 31 year old man with a large cell lymphoma which had evolved from chronic lymphocytic leukaemia (CLL). Molecular analysis showed a monoclonal proliferation of B cells with rearrangement of the immunoglobulin (Ig) heavy and kappa light chain genes, and of the bcl-3 gene on chromosome 19q. Nine cases with t(14;19) from the literature were reviewed; B cell lymphoma had been diagnosed in eight and acute biphenotypic leukaemia in one of these cases. Four had transformed from CLL to a more aggressive disease, as in the present case. Two out of seven patients as well as the present one, with t(14;19) and CLL were young (less than 40). The t(14;19) is usually associated with other cytogenetic abnormalities; in our case a (15;16)(q15;p13) translocation was found and appears to be an additional nonrandom aberration in t(14;19) disorders.
authors.affiliation: a Centre for Human Genetics, University of Leuven, Leuven, Belgium.
authors.forename: A M
authors.initials: AM
authors.lastname: Busschots
authors.affiliation: a Centre for Human Genetics, University of Leuven, Leuven, Belgium.
authors.forename: C
authors.initials: C
authors.lastname: Mecucci
authors.affiliation: a Centre for Human Genetics, University of Leuven, Leuven, Belgium.
authors.forename: M
authors.initials: M
authors.lastname: Stul
authors.affiliation: a Centre for Human Genetics, University of Leuven, Leuven, Belgium.
authors.forename: E
authors.initials: E
authors.lastname: Vandenberghe
authors.affiliation: b Department of Hematology, Brussels, Belgium.
authors.forename: J L
authors.initials: JL
authors.lastname: Michaux
authors.affiliation: c Department of Pathology, U.C.L., Brussels, Belgium.
authors.forename: H
authors.initials: H
authors.lastname: Noel
authors.affiliation: a Centre for Human Genetics, University of Leuven, Leuven, Belgium.
authors.forename: J J
authors.initials: JJ
authors.lastname: Cassiman
authors.affiliation: a Centre for Human Genetics, University of Leuven, Leuven, Belgium.
authors.forename: H
authors.initials: H
authors.lastname: Van Den Berghe
keywords: 14;19 translocation; CLL; NHL; large cell lymphoma