title: Successful Treatment of Aspergillus Empyema Using Open Window Thoracostomy Salvage Treatment and the Local Administration of an Antifungal Agent.
abstract: A 76-year-old woman received long-term immunosuppressive treatment for collagen vascular disease-associated interstitial pneumonia. The patient developed a cavitary mass lesion in the right lower lung field, and both nontuberculous mycobacteria and Aspergillus spp. were isolated after bronchial washing. The patient underwent a right lower lobectomy but developed Aspergillus empyema. Empyema due to Aspergillus spp. is a rare and life-threatening condition; however, the standard therapeutic strategies for treating Aspergillus empyema are not clear. We herein report a case of Aspergillus empyema that was successfully treated with a combination therapy which included open-window thoracostomy and the administration of antifungal agents (systemic micafungin and local amphotericin-B).
authors.affiliation: Department of Respiratory Medicine, Nagasaki University Graduate School of Biomedical Sciences, Japan.
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Ashizawa
authors.forename: Shigeki
authors.initials: S
authors.lastname: Nakamura
authors.forename: Shotaro
authors.initials: S
authors.lastname: Ide
authors.forename: Masato
authors.initials: M
authors.lastname: Tashiro
authors.forename: Takahiro
authors.initials: T
authors.lastname: Takazono
authors.forename: Yoshifumi
authors.initials: Y
authors.lastname: Imamura
authors.forename: Taiga
authors.initials: T
authors.lastname: Miyazaki
authors.forename: Koichi
authors.initials: K
authors.lastname: Izumikawa
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Yamamoto
authors.forename: Katsunori
authors.initials: K
authors.lastname: Yanagihara
authors.forename: Yoshitsugu
authors.initials: Y
authors.lastname: Miyazaki
authors.forename: Shigeru
authors.initials: S
authors.lastname: Kohno
mesh_terms: D000368:Aged; D000935:Antifungal Agents / Q000627:therapeutic use*; D016724:Empyema, Pleural / Q000188:drug therapy* / Q000601:surgery*; D005260:Female; D006801:Humans; D055732:Pulmonary Aspergillosis / Q000188:drug therapy* / Q000601:surgery*; D016879:Salvage Therapy; D013908:Thoracotomy / Q000379:methods*; D016896:Treatment Outcome
chemical_list: D000935:Antifungal Agents