title: BET bromodomain proteins and epigenetic regulation of inflammation: implications for type 2 diabetes and breast cancer.
abstract: Chronic inflammation drives pathologies associated with type 2 diabetes (T2D) and breast cancer. Obesity-driven inflammation may explain increased risk and mortality of breast cancer with T2D reported in the epidemiology literature. Therapeutic approaches to target inflammation in both T2D and cancer have so far fallen short of the expected improvements in disease pathogenesis or outcomes. The targeting of epigenetic regulators of cytokine transcription and cytokine signaling offers one promising, untapped approach to treating diseases driven by inflammation. Recent work has deeply implicated the Bromodomain and Extra-Terminal domain (BET) proteins, which are acetylated histone "readers", in epigenetic regulation of inflammation. This review focuses on inflammation associated with T2D and breast cancer, and the possibility of targeting BET proteins as an approach to regulating inflammation in the clinic. Understanding inflammation in the context of BET protein regulation may provide a basis for designing promising therapeutics for T2D and breast cancer.
authors.affiliation: Cancer Center, Boston University School of Medicine, 72 East Concord Street, Room K520, Boston, MA, 02118, USA.|Department of Microbiology, Training Program in Inflammatory Disorders, 72 East Concord Street, K520, Boston, MA, 02118, USA.
authors.forename: Dequina A
authors.initials: DA
authors.lastname: Nicholas
authors.affiliation: Cancer Center, Boston University School of Medicine, 72 East Concord Street, Room K520, Boston, MA, 02118, USA.
authors.forename: Guillaume
authors.initials: G
authors.lastname: Andrieu
authors.affiliation: Cancer Center, Boston University School of Medicine, 72 East Concord Street, Room K520, Boston, MA, 02118, USA.
authors.forename: Katherine J
authors.initials: KJ
authors.lastname: Strissel
authors.affiliation: Department of Microbiology, Training Program in Inflammatory Disorders, 72 East Concord Street, K520, Boston, MA, 02118, USA.
authors.forename: Barbara S
authors.initials: BS
authors.lastname: Nikolajczyk
authors.affiliation: Cancer Center, Boston University School of Medicine, 72 East Concord Street, Room K520, Boston, MA, 02118, USA. gdenis@bu.edu.|Section of Hematology/Oncology, Department of Pharmacology and Experimental Therapeutics, Boston University School of Medicine, 72 East Concord Street, K520, Boston, MA, 02118, USA. gdenis@bu.edu.
authors.forename: Gerald V
authors.identifier: 0000-0001-9886-0401
authors.initials: GV
authors.lastname: Denis
mesh_terms: D001943:Breast Neoplasms / Q000235:genetics*; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics*; D044127:Epigenesis, Genetic; D005260:Female; D006801:Humans; D007249:Inflammation / Q000235:genetics*; D009687:Nuclear Proteins / Q000378:metabolism*; D009765:Obesity / Q000235:genetics
chemical_list: D009687:Nuclear Proteins
keywords: Chromatin reader; Metabolism