title: Noise-induced multistability in the regulation of cancer by genes and pseudogenes.
abstract: We extend a previously introduced model of stochastic gene regulation of cancer to a nonlinear case having both gene and pseudogene messenger RNAs (mRNAs) self-regulated. The model consists of stochastic Boolean genetic elements and possesses noise-induced multistability (multimodality). We obtain analytical expressions for probabilities for the case of constant but finite number of microRNA molecules which act as a noise source for the competing gene and pseudogene mRNAs. The probability distribution functions display both the global bistability regime as well as even-odd number oscillations for a certain range of model parameters. Statistical characteristics of the mRNA's level fluctuations are evaluated. The obtained results of the extended model advance our understanding of the process of stochastic gene and pseudogene expressions that is crucial in regulation of cancer.
authors.affiliation: Institute of Physics, Academia Sinica, Nankang, Taipei 11529, Taiwan.
authors.forename: K G
authors.initials: KG
authors.lastname: Petrosyan
authors.affiliation: Institute of Physics, Academia Sinica, Nankang, Taipei 11529, Taiwan.
authors.forename: Chin-Kun
authors.initials: CK
authors.lastname: Hu
mesh_terms: D000465:Algorithms; D015972:Gene Expression Regulation, Neoplastic; D035683:MicroRNAs / Q000378:metabolism; D008957:Models, Genetic; D009369:Neoplasms / Q000235:genetics* / Q000378:metabolism*; D010507:Periodicity; D011544:Pseudogenes; D012333:RNA, Messenger / Q000378:metabolism; D013269:Stochastic Processes
chemical_list: D035683:MicroRNAs; D012333:RNA, Messenger