title: Prevention of Cervix Cancer in India.
abstract: Cervical cancer is the fourth most common cancer among women globally and the second most common cancer among Indian women. India alone bears 23% of the global cervical cancer burden. In India, population-based cervical cancer screening is largely nonexistent in most regions due to competing healthcare priorities, insufficient financial resources and a limited number of trained providers. Hence, most of the cases present in advanced stages of the disease, thus leading to increased mortality and reduced survival. Various screening options like cytology, visual-based screening and testing for high-risk HPV are available. Several cross-sectional studies have looked at the comparative efficacy of different screening tests. Three important randomized controlled trials from India have shown the efficacy of screening once in a life time with HPV DNA, one-time screening with VIA by trained nurses and four-time screening with VIA by trained primary health workers, reducing mortality due to cervical cancers. Prevention of cervical cancers with two-dose HPV vaccination and early detection of precancerous cervical lesions of the eligible population through screening and their appropriate treatment with a single-visit 'screen-and-treat' approach appear to be promising for low-middle-income countries including India.
authors.affiliation: Department of Preventive Oncology, Tata Memorial Hospital, Mumbai, India.
authors.forename: Gauravi A
authors.initials: GA
authors.lastname: Mishra
authors.forename: Sharmila A
authors.initials: SA
authors.lastname: Pimple
authors.forename: Surendra S
authors.initials: SS
authors.lastname: Shastri
mesh_terms: D019342:Acetic Acid; D003906:Developing Countries; D055088:Early Detection of Cancer / Q000379:methods*; D005260:Female; D006801:Humans; D007194:India; D007202:Indicators and Reagents; D030361:Papillomavirus Infections / Q000175:diagnosis / Q000517:prevention & control*; D053918:Papillomavirus Vaccines; D002583:Uterine Cervical Neoplasms / Q000175:diagnosis / Q000517:prevention & control*; D014611:Vaccination
chemical_list: D007202:Indicators and Reagents; D053918:Papillomavirus Vaccines; D019342:Acetic Acid