title: The antihyperlipidemic activities of enzymatic and acidic intracellular polysaccharides by Termitomyces albuminosus.
abstract: Two polysaccharides, EIPS and AIPS were obtained by the hydrolysis of IPS from Termitomyces albuminosus, and their pharmacological effects on blood lipid profiles metabolism and oxidative stress were investigated. The results demonstrated that EIPS was superior to IPS and AIPS on reducing hepatic lipid levels and preventing oxidative stress by improving serum enzyme activities (ALT, AST, and ALP), serum lipid levels (TC, TG, HDL-C, LDL-C and VLDL-C), hepatic lipid levels (TC and TG), and antioxidant status (SOD, GSH-Px, CAT, T-AOC, MDA, and LPO). These conclusions indicated that EIPS, AIPS and IPS might be suitable for functional foods and natural drugs on preventing the high-fat emulsion-induced hyperlipidemia. In addition, the monosaccharide compositions of IPS and its hydrolyzate were also processed.
authors.affiliation: Institute of Plant and Environment Protection, Beijing Academy of Agriculture and Forestry Sciences, Beijing Engineering Research Center for Edible Mushroom, Key Laboratory of Urban Agriculture (North), Ministry of Agriculture, Beijing 100097, PR China; College of Life Science, Shandong Agricultural University, Taian 271018, PR China.
authors.forename: Huajie
authors.initials: H
authors.lastname: Zhao
authors.affiliation: College of Life Science, Shandong Agricultural University, Taian 271018, PR China.
authors.forename: Shangshang
authors.initials: S
authors.lastname: Li
authors.affiliation: College of Life Science, Shandong Agricultural University, Taian 271018, PR China.
authors.forename: Jianjun
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Shandong Academy of Agricultural Science, Jinan 250100, PR China.
authors.forename: Gen
authors.initials: G
authors.lastname: Che
authors.affiliation: Quality and Safety Monitoring Center of Animal Products, Jinan 250002, PR China.
authors.forename: Meng
authors.initials: M
authors.lastname: Zhou
authors.affiliation: College of Life Science, Shandong Agricultural University, Taian 271018, PR China.
authors.forename: Min
authors.initials: M
authors.lastname: Liu
authors.affiliation: College of Life Science, Shandong Agricultural University, Taian 271018, PR China.
authors.forename: Chen
authors.initials: C
authors.lastname: Zhang
authors.affiliation: College of Life Science, Shandong Agricultural University, Taian 271018, PR China.
authors.forename: Nuo
authors.initials: N
authors.lastname: Xu
authors.affiliation: College of Life Science, Shandong Agricultural University, Taian 271018, PR China.
authors.forename: Lin
authors.initials: L
authors.lastname: Lin
authors.affiliation: Institute of Plant and Environment Protection, Beijing Academy of Agriculture and Forestry Sciences, Beijing Engineering Research Center for Edible Mushroom, Key Laboratory of Urban Agriculture (North), Ministry of Agriculture, Beijing 100097, PR China. Electronic address: ly6828@sina.com.
authors.forename: Yu
authors.initials: Y
authors.lastname: Liu
authors.affiliation: College of Life Science, Shandong Agricultural University, Taian 271018, PR China. Electronic address: jiale0525@163.com.
authors.forename: Le
authors.initials: L
authors.lastname: Jia
mesh_terms: D000975:Antioxidants / Q000378:metabolism; D001835:Body Weight / Q000187:drug effects; D004798:Enzymes / Q000378:metabolism*; D006863:Hydrogen-Ion Concentration; D006868:Hydrolysis; D000960:Hypolipidemic Agents / Q000737:chemistry / Q000494:pharmacology*; D042541:Intracellular Space / Q000737:chemistry*; D015227:Lipid Peroxidation / Q000187:drug effects; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008315:Malondialdehyde / Q000378:metabolism; D009005:Monosaccharides / Q000032:analysis; D018384:Oxidative Stress / Q000187:drug effects; D011134:Polysaccharides / Q000737:chemistry / Q000494:pharmacology*; D055434:Termitomyces / Q000166:cytology*
chemical_list: D000975:Antioxidants; D004798:Enzymes; D000960:Hypolipidemic Agents; D009005:Monosaccharides; D011134:Polysaccharides; D008315:Malondialdehyde
keywords: Antihyperlipidemic; Antioxidant; Hepatoprotective; Intracellular polysaccharides; Termitomyces albuminosus