title: [Not Available].
abstract: The incidence of mesothelioma in Italy shows wide geographical variation, with the highest incidence rates in Genoa and Friuli Venezia Giulia (FVG). For mesothelioma, national standard incidence rates are not available prior to the calendar year 2006.
  
  
  
  To estimate the Standardized Incidence rate Ratio (SIR) of mesothelioma in a cohort of former workers undergoing health surveillance because of previous asbestos exposure, when sex-, age-, and calendar year-specific rates of the national standard are not available and the number of expected cases calculated from the regional rates is biased by the size of the study cohort.
  
  
  
  We conducted a sensitivity analysis in a cohort of 2,488 men. We considered every Italian cancer registry available with complete data in the period 1995-2007 (N=14). We calculated, for each year and age group, the corresponding weighted mean rate of 10 registries of North-Italy (Mean W10), the weighted mean rate of all 14 registries available (Mean W14) and considered FVG standard rate.
  
  
  
  During the period 1995-2007, we observed 25 incident cases of mesothelioma with expected cases that varied between 2.00 (Mean W14) and 2.56 (FVG standard rate), with a SIR of 12.49 (CI95% 8.08-18.48) and 9.76 (CI95% 6.32-14.45) respectively.
  
  
  
  Our results show that the use of FVG rates as standard does not lead to significant distortions in the calculation of the expected cases. However, distortion is remarkable in the SIRs estimation. Using a weighted mean standard incidence rate may be a valid alternative for SIR estimate when national standard rates are not available.
authors.affiliation: Dipartimento di Scienze Mediche e Biologiche, Università di Udine, Udine, Italia Dipartimento di Medicina Clinica e Sperimentale, Università di Parma, Parma, Italia Servizio Prevenzione Igiene e Sicurezza negli Ambienti di Lavoro (SPISAL), ULSS n. 12, Mestre, Italia. fabiano.barbiero@uniud.it.
authors.forename: Fabiano
authors.initials: F
authors.lastname: Barbiero
authors.forename: Manuela
authors.initials: M
authors.lastname: Giangreco
authors.forename: Federica Edith
authors.initials: FE
authors.lastname: Pisa
authors.forename: Corrado
authors.initials: C
authors.lastname: Negro
authors.forename: Massimo
authors.initials: M
authors.lastname: Bovenzi
authors.forename: Valentina
authors.initials: V
authors.lastname: Rosolen
authors.forename: Fabio
authors.initials: F
authors.lastname: Barbone
mesh_terms: D001194:Asbestos / Q000009:adverse effects*; D015331:Cohort Studies; D006801:Humans; D015994:Incidence; D007558:Italy / Q000453:epidemiology; D008297:Male; D008654:Mesothelioma / Q000453:epidemiology* / Q000209:etiology*; D009784:Occupational Diseases / Q000453:epidemiology* / Q000209:etiology*; D016273:Occupational Exposure / Q000009:adverse effects*
chemical_list: D001194:Asbestos
keywords: Analisi di Sensibilità, Sir, Mesotelioma, Amianto/Sensitivity Analysis, Sir, Mesothelioma, Asbestos