title: Strength Training Prevents Hyperinsulinemia, Insulin Resistance, and Inflammation Independent of Weight Loss in Fructose-Fed Animals.
abstract: The aim of this study was to compare the effects of aerobic, strength, and combined training on metabolic disorders induced by a fructose-rich diet. Wistar rats (120 days old) were randomized into five groups (n = 8-14): C (control diet and sedentary), F (fed the fructose-rich diet and sedentary), FA (fed the fructose-rich diet and subject to aerobic exercise), FS (fed the fructose-rich diet and subject to strength exercise), and FAS (fed the fructose-rich diet and subject to combined aerobic and strength exercises). After the 8-week experiment, glucose homeostasis, blood biochemistry, tissue triglycerides, and inflammation were evaluated and analyzed. The strength protocol exerted greater effects on glucose homeostasis, insulin sensitivity, and liver lipid contents than other protocols (all P < 0.05). All three exercise protocols induced a remarkable reduction in inflammation, tissue triglyceride content, and inflammatory pathways, which was achieved through c-Jun NH2-terminal kinase (JNK) phosphorylation and factor nuclear kappa B (NFkB) activation in both the liver and the muscle. Our data suggest that strength training reduced the severity of most of the metabolic disorders induced by a fructose-rich diet and could be the most effective strategy to prevent or treat fructose-induced metabolic diseases.
authors.affiliation: Department of Nutrition, Metabolism and Exercise, Campinas State University (UNICAMP), Limeira/SP, Brazil.|Medical Sciences University, Campinas State University (UNICAMP), Campinas/SP, Brazil.
authors.forename: José D
authors.initials: JD
authors.lastname: Botezelli
authors.affiliation: Medical Sciences University, Campinas State University (UNICAMP), Campinas/SP, Brazil.
authors.forename: Andressa
authors.initials: A
authors.lastname: Coope
authors.affiliation: Medical Sciences University, Campinas State University (UNICAMP), Campinas/SP, Brazil.
authors.forename: Ana C
authors.initials: AC
authors.lastname: Ghezzi
authors.affiliation: Department of Physical Education, Mato Grosso Federal University (UFMT), Cuiabá/MT, Brazil.
authors.forename: Lucieli T
authors.initials: LT
authors.lastname: Cambri
authors.affiliation: Department of Nutrition, Metabolism and Exercise, Campinas State University (UNICAMP), Limeira/SP, Brazil.
authors.forename: Leandro P
authors.initials: LP
authors.lastname: Moura
authors.affiliation: Department of Nutrition, Metabolism and Exercise, Campinas State University (UNICAMP), Limeira/SP, Brazil.
authors.forename: Pedro P M
authors.initials: PP
authors.lastname: Scariot
authors.affiliation: Department of Nutrition, Metabolism and Exercise, Campinas State University (UNICAMP), Limeira/SP, Brazil.
authors.forename: Rodrigo Stellzer
authors.initials: RS
authors.lastname: Gaspar
authors.affiliation: Department of Pharmaceutical Business and Administrative Sciences; MCPHS University, Boston/MA, USA.|Department of Surgery; Brigham and Women's Hospital, Harvard Medical School, Boston/MA, USA.
authors.forename: Rania A
authors.initials: RA
authors.lastname: Mekary
authors.affiliation: Department of Nutrition, Metabolism and Exercise, Campinas State University (UNICAMP), Limeira/SP, Brazil.
authors.forename: Eduardo Rochete
authors.initials: ER
authors.lastname: Ropelle
authors.affiliation: Department of Nutrition, Metabolism and Exercise, Campinas State University (UNICAMP), Limeira/SP, Brazil.
authors.forename: José Rodrigo
authors.initials: JR
authors.lastname: Pauli
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D004040:Dietary Carbohydrates / Q000008:administration & dosage / Q000009:adverse effects; D005632:Fructose / Q000008:administration & dosage* / Q000009:adverse effects; D006946:Hyperinsulinism / Q000097:blood / Q000517:prevention & control*; D015228:Hypertriglyceridemia / Q000209:etiology; D007249:Inflammation / Q000517:prevention & control*; D007333:Insulin Resistance; D008099:Liver / Q000378:metabolism / Q000473:pathology; D008297:Male; D008659:Metabolic Diseases / Q000209:etiology / Q000503:physiopathology / Q000517:prevention & control; D010805:Physical Conditioning, Animal / Q000379:methods*; D051381:Rats; D017208:Rats, Wistar; D055070:Resistance Training; D015431:Weight Loss
chemical_list: D001786:Blood Glucose; D004040:Dietary Carbohydrates; D005632:Fructose