title: MODELING H-ARS USING HEMATOLOGICAL PARAMETERS: A COMPARISON BETWEEN THE NON-HUMAN PRIMATE AND MINIPIG.
abstract: Multiple hematological biomarkers (i.e. complete blood counts and serum chemistry parameters) were used in a multivariate linear-regression fit to create predictive algorithms for estimating the severity of hematopoietic acute radiation syndrome (H-ARS) using two different species (i.e. Göttingen Minipig and non-human primate (NHP) (Macacca mulatta)). Biomarker data were analyzed prior to irradiation and between 1-60 days (minipig) and 1-30 days (NHP) after irradiation exposures of 1.6-3.5 Gy (minipig) and 6.5 Gy (NHP)60Co gamma ray doses at 0.5-0.6 Gy min-1and 0.4 Gy min-1, respectively. Fitted radiation risk and injury categorization (RRIC) values and RRIC prediction percent accuracies were compared between the two models. Both models estimated H-ARS severity with over 80% overall predictive power and with receiver operating characteristic curve area values of 0.884 and 0.825. These results based on two animal radiation models support the concept for the use of a hematopoietic-based algorithm for predicting the risk of H-ARS in humans.
authors.affiliation: Scientific Research Department, Armed Forces Radiobiology Research Institute, Uniformed Services University of the Health Sciences, 8901 Wisconsin Avenue, Bethesda, MD 20889-5603, USA david.bolduc@usuhs.edu.
authors.forename: David L
authors.initials: DL
authors.lastname: Bolduc
authors.affiliation: Scientific Research Department, Armed Forces Radiobiology Research Institute, Uniformed Services University of the Health Sciences, 8901 Wisconsin Avenue, Bethesda, MD 20889-5603, USA.
authors.forename: Rolf
authors.initials: R
authors.lastname: Bünger
authors.affiliation: Scientific Research Department, Armed Forces Radiobiology Research Institute, Uniformed Services University of the Health Sciences, 8901 Wisconsin Avenue, Bethesda, MD 20889-5603, USA.
authors.forename: Maria
authors.initials: M
authors.lastname: Moroni
authors.affiliation: Scientific Research Department, Armed Forces Radiobiology Research Institute, Uniformed Services University of the Health Sciences, 8901 Wisconsin Avenue, Bethesda, MD 20889-5603, USA.
authors.forename: William F
authors.initials: WF
authors.lastname: Blakely
mesh_terms: D054508:Acute Radiation Syndrome / Q000097:blood* / Q000175:diagnosis*; D000818:Animals; D001681:Biological Assay / Q000379:methods*; D015415:Biomarkers / Q000097:blood; D003198:Computer Simulation; D006402:Hematologic Diseases / Q000097:blood* / Q000175:diagnosis*; D006801:Humans; D008253:Macaca mulatta; D008955:Models, Cardiovascular; D011874:Radiometry / Q000379:methods*; D015203:Reproducibility of Results; D018570:Risk Assessment / Q000379:methods; D012680:Sensitivity and Specificity; D013045:Species Specificity; D013552:Swine; D013556:Swine, Miniature
chemical_list: D015415:Biomarkers