title: Poly-carboxylic acids functionalized chitosan nanocarriers for controlled and targeted anti-cancer drug delivery.
abstract: The present study evaluates the in-vitro cisplatin (CDDP) release from four different poly oxalates cross-linked chitosan (CS) nanocomposites. The poly oxalates were synthesized from the reaction of four different dicarboxylic acids with ethylene glycol (EG). The encapsulation of CDDP on CS cross-linked with Oxalic acid-EG, Succinic acid-EG, Citric acid-EG and tartaric acid-EG carriers were carried out by the ionic gelation technique. The poly-oxalate nanocarriers were characterized by scanning electron microscopy, atomic force microscopy, X-ray diffraction studies and zeta potential analysis. The stability of poly-oxalates was calculated by the density functional theory (DFT) using Gaussview 05. Excellent drug release kinetics and good biocompatibility of nanocomposites were observed for the in-vitro analysis. The unloaded poly oxalate nanocomposites perform to have a low inherent cytotoxicity, whereas the loaded nanocomposites were as active as free CDDP in the MCF-7 cancer cell line. The tumor growth inhibitions of CDDP-loaded nanocomposites are more or equal to that of free CDDP. Taken together, these two poly oxalate nanocomposites are established as promising drug carriers for the delivery of CDDP.
authors.affiliation: Biomaterials in Medicinal Chemistry Laboratory, Department of Natural Products Chemistry, School of Chemistry, Madurai Kamaraj University, Madurai 625 021, Tamil Nadu, India. Electronic address: rajanm153@gmail.com.
authors.forename: Mariappan
authors.initials: M
authors.lastname: Rajan
authors.affiliation: Department of Microbial Technology, School of Biological Science, Madurai Kamaraj University, Madurai 625 021, Tamil Nadu, India.
authors.forename: Maruthamuthu
authors.initials: M
authors.lastname: Murugan
authors.affiliation: Center for Advanced Materials, Qatar University, 2713 Doha, Qatar.
authors.forename: Deepalekshmi
authors.initials: D
authors.lastname: Ponnamma
authors.affiliation: Center for Advanced Materials, Qatar University, 2713 Doha, Qatar.
authors.forename: Kishor Kumar
authors.initials: KK
authors.lastname: Sadasivuni
authors.affiliation: Department of Botany and Microbiology, College of Science, King Saud University, Riyadh 11451, Saudi Arabia.
authors.forename: Murugan A
authors.initials: MA
authors.lastname: Munusamy
mesh_terms: D000970:Antineoplastic Agents / Q000494:pharmacology*; D002264:Carboxylic Acids / Q000737:chemistry*; D016923:Cell Death / Q000187:drug effects; D048271:Chitosan / Q000737:chemistry*; D002945:Cisplatin / Q000494:pharmacology; D003692:Delayed-Action Preparations; D004337:Drug Carriers / Q000737:chemistry*; D016503:Drug Delivery Systems; D065546:Drug Liberation; D006801:Humans; D061986:MCF-7 Cells; D018625:Microscopy, Atomic Force; D053761:Nanocomposites / Q000737:chemistry* / Q000648:ultrastructure; D055672:Static Electricity; D014961:X-Ray Diffraction
chemical_list: D000970:Antineoplastic Agents; D002264:Carboxylic Acids; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D048271:Chitosan; D002945:Cisplatin
keywords: Chitosan; Cisplatin; Drug delivery; Ionic gelation; Nanocomposites; Polyoxalate