title: Activity of Ceftazidime-Avibactam against Clinical and Isogenic Laboratory Pseudomonas aeruginosa Isolates Expressing Combinations of Most Relevant β-Lactam Resistance Mechanisms.
abstract: The activity of ceftazidime-avibactam was compared with that of ceftazidime alone and meropenem against a collection of 190 Pseudomonas aeruginosa clinical isolates recovered from a multicenter study of bloodstream infections. The addition of avibactam increased ceftazidime susceptibility in the complete collection of strains (64.7% to 91.1%) and particularly among subsets of isolates showing AmpC hyperproduction (10.9% to 76.1%) or multidrug resistance (MDR) profiles (27% to 77.8%). The MICs of ceftazidime-avibactam, in contrast with those of ceftazidime or meropenem, remained at ≤4 μg/ml for a panel of 16 P. aeruginosa PAO1 isogenic mutants expressing multiple combinations of the most relevant β-lactam resistance mechanisms.
authors.affiliation: Servicio de Microbiología and Unidad de Investigación, Hospital Universitario Son Espases, Instituto de Investigación Sanitaria de Palma (IdISPa), Palma de Mallorca, Spain Spanish Network for Research in Infectious Diseases (REIPI), Seville, Spain.
authors.forename: Gabriel
authors.initials: G
authors.lastname: Torrens
authors.affiliation: Servicio de Microbiología and Unidad de Investigación, Hospital Universitario Son Espases, Instituto de Investigación Sanitaria de Palma (IdISPa), Palma de Mallorca, Spain Spanish Network for Research in Infectious Diseases (REIPI), Seville, Spain gabriel.cabot@ssib.es.
authors.forename: Gabriel
authors.identifier: 0000-0002-6452-9945
authors.initials: G
authors.lastname: Cabot
authors.affiliation: Spanish Network for Research in Infectious Diseases (REIPI), Seville, Spain Servicio de Microbiología, Hospital Universitario Marqués de Valdecilla-IDIVAL, Santander, Spain.
authors.forename: Alain A
authors.initials: AA
authors.lastname: Ocampo-Sosa
authors.affiliation: Spanish Network for Research in Infectious Diseases (REIPI), Seville, Spain Hospital Universitario Virgen Macarena, Instituto de Biomédicina de Sevilla (IBiS), Universidad de Sevilla, Seville, Spain.
authors.forename: M Carmen
authors.initials: MC
authors.lastname: Conejo
authors.affiliation: Servicio de Microbiología and Unidad de Investigación, Hospital Universitario Son Espases, Instituto de Investigación Sanitaria de Palma (IdISPa), Palma de Mallorca, Spain Spanish Network for Research in Infectious Diseases (REIPI), Seville, Spain.
authors.forename: Laura
authors.initials: L
authors.lastname: Zamorano
authors.affiliation: Spanish Network for Research in Infectious Diseases (REIPI), Seville, Spain Servicio de Microbiología, Hospital de Sant Pau, Barcelona, Spain.
authors.forename: Ferrán
authors.identifier: 0000-0002-4302-2838
authors.initials: F
authors.lastname: Navarro
authors.affiliation: Spanish Network for Research in Infectious Diseases (REIPI), Seville, Spain Hospital Universitario Virgen Macarena, Instituto de Biomédicina de Sevilla (IBiS), Universidad de Sevilla, Seville, Spain.
authors.forename: Álvaro
authors.initials: Á
authors.lastname: Pascual
authors.affiliation: Spanish Network for Research in Infectious Diseases (REIPI), Seville, Spain Servicio de Microbiología, Hospital Universitario Marqués de Valdecilla-IDIVAL, Santander, Spain Departamento de Biología Molecular, Universidad de Cantabria, Santander, Spain.
authors.forename: Luis
authors.initials: L
authors.lastname: Martínez-Martínez
authors.affiliation: Servicio de Microbiología and Unidad de Investigación, Hospital Universitario Son Espases, Instituto de Investigación Sanitaria de Palma (IdISPa), Palma de Mallorca, Spain Spanish Network for Research in Infectious Diseases (REIPI), Seville, Spain.
authors.forename: Antonio
authors.initials: A
authors.lastname: Oliver
mesh_terms: D053961:Azabicyclo Compounds / Q000494:pharmacology*; D002442:Ceftazidime / Q000494:pharmacology*; D004338:Drug Combinations; D006801:Humans; D000077731:Meropenem; D008826:Microbial Sensitivity Tests; D011550:Pseudomonas aeruginosa / Q000187:drug effects* / Q000302:isolation & purification; D013845:Thienamycins / Q000494:pharmacology; D018440:beta-Lactam Resistance / Q000187:drug effects*
chemical_list: D053961:Azabicyclo Compounds; D004338:Drug Combinations; D013845:Thienamycins; C000595613:avibactam, ceftazidime drug combination; D002442:Ceftazidime; D000077731:Meropenem