title: Simultaneous determination of environmental estrogens: Diethylstilbestrol and estradiol using Cu-BTC frameworks-sensitized electrode.
abstract: It is quite important to monitor environmental estrogens in a rapid, sensitive, simple and cost-effective manner due to their wide existence and high toxicity. Using 1,3,5-Benzenetricarboxylic acid (H3BTC) as the ligand and copper ions as the center, Cu-BTC frameworks with surface area of 654.6m(2)/g were prepared, and then used to construct a novel electrochemical sensing platform for diethylstilbestrol (DES) and estradiol (E2). On the surface of Cu-BTC frameworks, two oxidation waves at 0.26V and 0.45V are observed for DES and E2, and the oxidation signals are improved greatly. The prepared Cu-BTC frameworks not only enhance the accumulation efficiency of DES and E2, but also improve their electron transfer ability. The influences of pH value, modification amount of Cu-BTC and accumulation time were examined. As a result, a highly-sensitive, rapid and convenient electrochemical method was developed for the simultaneous determination of DES and E2, with detection limit of 2.7nM and 1.1nM. The practical applications manifest this new sensing system is accurate and feasible.
authors.affiliation: Key Laboratory for Material Chemistry of Energy Conversion and Storage, Ministry of Education, School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology, Wuhan 430074, China.
authors.forename: Liudi
authors.initials: L
authors.lastname: Ji
authors.affiliation: Key Laboratory for Material Chemistry of Energy Conversion and Storage, Ministry of Education, School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology, Wuhan 430074, China.
authors.forename: Yanying
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Key Laboratory for Material Chemistry of Energy Conversion and Storage, Ministry of Education, School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology, Wuhan 430074, China. Electronic address: kbwu@hust.edu.cn.
authors.forename: Kangbing
authors.initials: K
authors.lastname: Wu
authors.affiliation: Department of Gastrointestinal Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China. Electronic address: weikangzhang11@163.com.
authors.forename: Weikang
authors.initials: W
authors.lastname: Zhang
mesh_terms: D003300:Copper / Q000737:chemistry*; D004054:Diethylstilbestrol / Q000032:analysis*; D004566:Electrodes; D004784:Environmental Monitoring / Q000379:methods*; D004958:Estradiol / Q000032:analysis*; D057230:Limit of Detection; D014233:Tricarboxylic Acids / Q000737:chemistry*
chemical_list: D014233:Tricarboxylic Acids; D004958:Estradiol; D004054:Diethylstilbestrol; D003300:Copper; C069849:trimesic acid
keywords: Cu-BTC frameworks; Diethylstilbestrol; Electrochemical sensor; Environmental estrogens; Estradiol