title: Contributions of the Central Extended Amygdala to Fear and Anxiety.
abstract: It is widely thought that phasic and sustained responses to threat reflect dissociable circuits centered on the central nucleus of the amygdala (Ce) and the bed nucleus of the stria terminalis (BST), the two major subdivisions of the central extended amygdala. Early versions of this hypothesis remain highly influential and have been incorporated into the National Institute of Mental Health Research Research Domain Criteria framework. However, new observations encourage a different perspective. Anatomical studies show that the Ce and BST form a tightly interconnected unit, where different kinds of threat-relevant information can be integrated and used to assemble states of fear and anxiety. Imaging studies in humans and monkeys show that the Ce and BST exhibit similar functional profiles. Both regions are sensitive to a range of aversive challenges, including uncertain or temporally remote threat; both covary with concurrent signs and symptoms of fear and anxiety; both show phasic responses to short-lived threat; and both show heightened activity during sustained exposure to diffusely threatening contexts. Mechanistic studies demonstrate that both regions can control the expression of fear and anxiety during sustained exposure to diffuse threat. These observations compel a reconsideration of the central extended amygdala's contributions to fear and anxiety and its role in neuropsychiatric disease.
authors.affiliation: Department of Psychology, Neuroscience and Cognitive Science Program, and Maryland Neuroimaging Center, University of Maryland, College Park, Maryland 20742, and shackman@umd.edu fox.drew@gmail.com.
authors.forename: Alexander J
authors.identifier: 0000-0002-3629-4704
authors.initials: AJ
authors.lastname: Shackman
authors.affiliation: Department of Psychology and California National Primate Research Center, University of California, Davis, California 95616 shackman@umd.edu fox.drew@gmail.com.
authors.forename: Andrew S
authors.initials: AS
authors.lastname: Fox
mesh_terms: D000818:Animals; D001007:Anxiety / Q000503:physiopathology* / Q000523:psychology*; D066272:Basolateral Nuclear Complex / Q000503:physiopathology*; D066274:Central Amygdaloid Nucleus / Q000503:physiopathology*; D019317:Evidence-Based Medicine; D019260:Expressed Emotion; D005239:Fear / Q000523:psychology*; D006801:Humans; D008959:Models, Neurological; D009415:Nerve Net / Q000503:physiopathology*; D011323:Primates
keywords: affective neuroscience; fMRI; fear and anxiety; mood and anxiety disorders; neuroimaging; nonhuman primates