title: Integrated Endoscopic System Based on Optical Imaging and Hyperspectral Data Analysis for Colorectal Cancer Detection.
abstract: OBJECTIVE
  Two-dimensional hyperspectral data systems with enhanced area detection and diagnostic abilities are now available in gastrointestinal endoscopy for colorectal cancer. We evaluated a new hyperspectral system for diagnosis of colorectal cancer.
  
  
  METHODS
  A resected-specimen spectrum observation module (stereoscopic macroscope, hyperspectral camera, and xenon lamp) was used to evaluate 21 resected colorectal cancer specimens (ex vivo experiment). A colonoscopy spectrum observation module (imaging fiberscope and hyperspectral camera) was used to perform 24 colonoscopic spectroscopy evaluations (in vivo experiment).
  
  
  RESULTS
  An approximately 525-nm increase in spectral absorption occurred between normal mucosa and adenoma, with a tendency toward decreased absorption rates with aggravation of other tumor types. In vivo discrimination between tumorous and non-tumorous tissues showed 72.5% sensitivity and 82.1% specificity.
  
  
  CONCLUSIONS
  This in vivo hyperspectral diagnostic system showed that reflectance spectra intensity may discriminate between normal and abnormal colonic mucosa.
authors.affiliation: Center for Integration of Advanced Medicine, Life Science and Innovative Technology, Kyushu University, Fukuoka, Japan Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
authors.forename: Ryuichi
authors.initials: R
authors.lastname: Kumashiro
authors.affiliation: Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
authors.forename: Kozo
authors.initials: K
authors.lastname: Konishi
authors.affiliation: PENTAX Lifecare Division, Hoya Corporation, Tokyo, Japan.
authors.forename: Tohru
authors.initials: T
authors.lastname: Chiba
authors.affiliation: Department of Disaster and Emergency Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
authors.forename: Tomohiko
authors.initials: T
authors.lastname: Akahoshi
authors.affiliation: Second Department of Internal Medicine Kyushu University Hospital, Fukuoka, Japan.
authors.forename: Shotaro
authors.initials: S
authors.lastname: Nakamura
authors.affiliation: Department of Disaster and Emergency Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
authors.forename: Masaharu
authors.initials: M
authors.lastname: Murata
authors.affiliation: Center for Integration of Advanced Medicine, Life Science and Innovative Technology, Kyushu University, Fukuoka, Japan Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
authors.forename: Morimasa
authors.initials: M
authors.lastname: Tomikawa
authors.affiliation: Second Department of Internal Medicine Kyushu University Hospital, Fukuoka, Japan.
authors.forename: Takayuki
authors.initials: T
authors.lastname: Matsumoto
authors.affiliation: Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
authors.forename: Yoshihiko
authors.initials: Y
authors.lastname: Maehara
authors.affiliation: Center for Integration of Advanced Medicine, Life Science and Innovative Technology, Kyushu University, Fukuoka, Japan Second Department of Internal Medicine Kyushu University Hospital, Fukuoka, Japan mhashi@dem.med.kyushu-u.ac.jp.
authors.forename: Makoto
authors.initials: M
authors.lastname: Hashizume
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001706:Biopsy; D003111:Colonic Polyps / Q000000981:diagnostic imaging / Q000473:pathology; D003113:Colonoscopy; D015179:Colorectal Neoplasms / Q000175:diagnosis* / Q000000981:diagnostic imaging* / Q000473:pathology / Q000601:surgery; D016099:Endoscopy, Gastrointestinal; D005260:Female; D006801:Humans; D007413:Intestinal Mucosa / Q000000981:diagnostic imaging / Q000473:pathology; D008297:Male; D008875:Middle Aged; D061848:Optical Imaging / Q000379:methods
keywords: Hyperspectral analysis; colonoscopy; optical biopsy; reluctant spectroscopy