title: EVALUATION OF ANTIOXIDANT ACTIVITY OF SOME IMINES DERIVATIVES OF L-ARGININE.
abstract: L-Arginine is an a-amino acid which plays important roles in different diseases or processes, such as Alzheimer disease, inflammatory process, healing and tissue regeneration and it also could be useful as an anti-atherosclerotic agent.
  
  
  OBJECTIVE
  Considering the large amount of studies on the beneficial effects of different antioxidants, this paper is focused on the evaluation of the antioxidant potential of some imine derivatives, synthesized by the authors and described in a previous article.
  
  
  METHODS
  The evaluation of the antioxidant power was performed using phosphomolydenum-reducing antioxidant power (PRAP) and ferric reducing antioxidant power (FRAP) assays, tests described in the literature and which are used with some minor modifications.
  
  
  RESULTS
  It was found that most of the imine derivatives are more active than the L-Arginine in the PPAP and FRAP assays. The most active derivative was the compound obtained by condensation of L-arginine with 2,3-dihydroxybenzaldehyde (2k) and 2-nitrobenzaldehyde (2g).
  
  
  CONCLUSIONS
  Following the described protocol, some imine derivatives of L-arginine were evaluated in terms of antioxidant potential using in vitro methods. The most favorable influence was obtained by the aromatic substitution with nitro and hydroxyl, the corresponding derivatives being the most active derivatives compared to L-arginine.
authors.forename: Andreea-Teodora
authors.initials: AT
authors.lastname: Iacob
authors.forename: Maria
authors.initials: M
authors.lastname: Drăgan
authors.forename: Sandra
authors.initials: S
authors.lastname: Constantin
authors.forename: Florentina
authors.initials: F
authors.lastname: Lupaşcu
authors.forename: Luminiţa
authors.initials: L
authors.lastname: Confederat
authors.forename: F
authors.initials: F
authors.lastname: Buron
authors.forename: S
authors.initials: S
authors.lastname: Routier
authors.forename: Lenuţa
authors.initials: L
authors.lastname: Profire
mesh_terms: D000975:Antioxidants / Q000138:chemical synthesis / Q000494:pharmacology*; D001120:Arginine / Q000138:chemical synthesis*; D001547:Benzaldehydes / Q000138:chemical synthesis*; D002396:Catechols / Q000138:chemical synthesis*; D004353:Drug Evaluation, Preclinical / Q000379:methods; D007097:Imines / Q000138:chemical synthesis / Q000494:pharmacology*; D066298:In Vitro Techniques
chemical_list: D000975:Antioxidants; D001547:Benzaldehydes; D002396:Catechols; D007097:Imines; C067077:2,3-dihydroxybenzaldehyde; C043850:2-nitrobenzaldehyde; D001120:Arginine