title: Hyperemesis gravidarum is associated with increased maternal serum ischemia-modified albumin.
abstract: OBJECTIVE
  Our objective was to measure the circulating levels of ischemia-modified albumin (IMA) among pregnant with hyperemesis gravidarum (HEG) and to compare their levels with age- and body mass index (BMI)-matched control pregnant women.
  
  
  METHODS
  The pregnant subjects were classified into the HEG group diagnosed with HEG (n=45) and age- and BMI-matched control group without a diagnosis of HEG (n=45) during their pregnancies. Serum IMA, hemoglobin, hematocrit, white blood cells, platelet, fasting blood glucose, creatinine, lipid profile, aspartate aminotransferase (AST) urea, alanine aminotransferase (ALT), sodium, potassium and thyroid-stimulating hormone (TSH) levels of the groups were measured.
  
  
  RESULTS
  Serum hemoglobin, hematocrit, white blood cells, platelet, fasting blood glucose, creatinine, lipid profile, AST, urea, ALT, sodium, potassium and TSH levels of the groups were statistically similar. Serum IMA values were significantly higher in subjects with HEG compared to the subjects without HEG.
  
  
  CONCLUSIONS
  We found that HEG was related to increased maternal serum IMA levels. HEG might be due to an ischemic intrauterine environment leading to elevated serum IMA concentrations.
authors.affiliation: , Faculty of Medicine.
authors.forename: Nagihan
authors.initials: N
authors.lastname: Sari
authors.affiliation: , Faculty of Medicine.
authors.forename: Hüseyin
authors.initials: H
authors.lastname: Ede
authors.affiliation: .
authors.forename: Yaprak
authors.initials: Y
authors.lastname: Engin-Ustun
authors.affiliation: , Faculty of Medicine.
authors.forename: Ayşe Yeşim
authors.initials: AY
authors.lastname: Göçmen
authors.affiliation: , Faculty of Medicine.
authors.forename: Emel Kıyak
authors.initials: EK
authors.lastname: Çağlayan
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D006939:Hyperemesis Gravidarum / Q000097:blood*; D011247:Pregnancy; D000075462:Serum Albumin, Human; D055815:Young Adult
chemical_list: D015415:Biomarkers; C561522:ischemia-modified albumin; D000075462:Serum Albumin, Human
keywords: Hyperemesis gravidarum; IMA; oxidative stress