title: The effect of cytomegalovirus infection on acute rejection in kidney transplanted patients.
abstract: BACKGROUND
  It is known that cytomegalovirus (CMV) infection is a common problem among kidney transplant patients. This infection can be increased morbidity and decreased graft survival. This problem has been associated with acute rejection too.
  
  
  METHODS
  One hundred and thirty renal transplant patients were included in a prospective, case-control study. The renal transplant patients were divided into two groups; patients group with CMV infection and control group without CMV infection. Serum CMV-IgG in all patients was positive (donor and recipients). None of patients had received anti-thymocyte-globulin and thymoglobulin. CMV infection was diagnosed by quantitative CMV-PCR (polymerase chain reaction) test (more than 500 copies/μg). Rejection episode was defined by kidney isotope scan or biopsy.
  
  
  RESULTS
  In the group of 66 CMV infection patients (41 male [62.1%] and 25 female [37.9%]) the incidence of graft rejection was 36%, however in the group of 64 control patients the incidence of graft rejection was 9.4 % (P < 0.005).
  
  
  CONCLUSIONS
  CMV infection is important predisposing factor for acute allograft rejection after kidney transplantation. The results of this study suggests that the control of CMV infection could decrease episodes of acute kidney rejection.
authors.affiliation: Kidney Transplantation Complications Research Center, Montaserie Organ Transplantation Hospital, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
authors.forename: Boshra
authors.initials: B
authors.lastname: Hasanzamani
authors.affiliation: Kidney Transplantation Complications Research Center, Montaserie Organ Transplantation Hospital, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
authors.forename: Maryam
authors.initials: M
authors.lastname: Hami
authors.affiliation: Kidney Transplantation Complications Research Center, Montaserie Organ Transplantation Hospital, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
authors.forename: Vajihe
authors.initials: V
authors.lastname: Zolfaghari
authors.affiliation: Kidney Transplantation Complications Research Center, Montaserie Organ Transplantation Hospital, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
authors.forename: Mahtab
authors.initials: M
authors.lastname: Torkamani
authors.affiliation: Kidney Transplantation Complications Research Center, Montaserie Organ Transplantation Hospital, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
authors.forename: Mahin
authors.initials: M
authors.lastname: Ghorban Sabagh
authors.affiliation: Kidney Transplantation Complications Research Center, Montaserie Organ Transplantation Hospital, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
authors.forename: Saiideh
authors.initials: S
authors.lastname: Ahmadi Simab
keywords: Acute rejection; Cytomegalovirus; Kidney transplantation