title: Hydrogen isotope exchange with highly active iridium(I) NHC/phosphine complexes: a comparative counterion study.
abstract: Herein, we present a range of substrates that undergo hydrogen isotope exchange with an iridium(I) N-heterocyclic carbene/phosphine complex bearing the less coordinating tetrakis[3,5-bis(trifluoromethyl)phenyl]borate counterion and compare these with labelling using the equivalent, more established hexafluorophosphate complex. The changes in reactivity and selectivity of these complexes in a series of solvents are examined. Copyright © 2016 John Wiley & Sons, Ltd.
authors.affiliation: Department of Pure and Applied Chemistry, WestCHEM, University of Strathclyde, Glasgow, Scotland, UK.
authors.forename: William J
authors.initials: WJ
authors.lastname: Kerr
authors.affiliation: Department of Pure and Applied Chemistry, WestCHEM, University of Strathclyde, Glasgow, Scotland, UK.
authors.forename: Richard J
authors.initials: RJ
authors.lastname: Mudd
authors.affiliation: Department of Pure and Applied Chemistry, WestCHEM, University of Strathclyde, Glasgow, Scotland, UK.
authors.forename: Philippa K
authors.initials: PK
authors.lastname: Owens
authors.affiliation: Department of Pure and Applied Chemistry, WestCHEM, University of Strathclyde, Glasgow, Scotland, UK.
authors.forename: Marc
authors.initials: M
authors.lastname: Reid
authors.affiliation: GlaxoSmithKline R&D, Medicines Research Centre, Stevenage, England, UK.
authors.forename: Jack A
authors.initials: JA
authors.lastname: Brown
authors.affiliation: GlaxoSmithKline R&D, Medicines Research Centre, Stevenage, England, UK.
authors.forename: Sebastien
authors.initials: S
authors.lastname: Campos
mesh_terms: D001895:Boron / Q000737:chemistry; D002384:Catalysis; D003903:Deuterium / Q000737:chemistry*; D007495:Iridium / Q000737:chemistry*; D009942:Organometallic Compounds / Q000737:chemistry*; D010720:Phosphines / Q000737:chemistry*; D014316:Tritium / Q000737:chemistry*
chemical_list: D009942:Organometallic Compounds; D010720:Phosphines; D014316:Tritium; D007495:Iridium; D003903:Deuterium; C044646:phosphine; D001895:Boron
keywords: N-heterocyclic carbene; deuteration; iridium; ortho-hydrogen isotope exchange