title: Progression and predictors of mild cognitive impairment in Chinese elderly: A prospective follow-up in the Shanghai Aging Study.
abstract: BACKGROUND
  The Shanghai Aging Study is a community-based study aiming to investigate the incidence and progression of cognitive decline in Chinese elderly, with the operational procedures and diagnostic criteria similar to cohort studies in developed countries.
  
  
  METHODS
  We prospectively evaluated 362 individuals with mild cognitive impairment (MCI) diagnosed at baseline through a clinical and neuropsychological interview. Diagnoses of dementia and MCI were made using standard criteria via consensus diagnosis.
  
  
  RESULTS
  The conversion rate to dementia was 6.0 per 100 person-years, while the reversion rate to cognitive normal was 7.8 per 100 person-years. Amnestic MCI multiple domains was the most risky type for dementia (conversion rate: 14.2 per 100 person-years). Older age (hazard ratio [HR] = 1.09), apolipoprotein E (APOE ε4) (HR = 2.15), and low MMSE score (HR = 1.18) were predictors for dementia.
  
  
  CONCLUSIONS
  Approximately 6% of elderly with MCI progress to dementia annually. Prospective studies are needed to further examine risk and protective predictors and to seek proper interventions for cognitive decline.
authors.affiliation: Institute of Neurology, Huashan Hospital, Fudan University, WHO Collaborating Center for Research and Training in Neurosciences, Shanghai, China.
authors.forename: Ding
authors.initials: D
authors.lastname: Ding
authors.affiliation: Institute of Neurology, Huashan Hospital, Fudan University, WHO Collaborating Center for Research and Training in Neurosciences, Shanghai, China.
authors.forename: Qianhua
authors.initials: Q
authors.lastname: Zhao
authors.affiliation: Institute of Neurology, Huashan Hospital, Fudan University, WHO Collaborating Center for Research and Training in Neurosciences, Shanghai, China.
authors.forename: Qihao
authors.initials: Q
authors.lastname: Guo
authors.affiliation: Department of Health Statistics, School of Public Health, Fudan University, Shanghai, China; The Key Laboratory of Public Health Safety, Fudan University, Shanghai, China.
authors.forename: Xiaoniu
authors.initials: X
authors.lastname: Liang
authors.affiliation: Department of Health Statistics, School of Public Health, Fudan University, Shanghai, China; The Key Laboratory of Public Health Safety, Fudan University, Shanghai, China.
authors.forename: Jianfeng
authors.initials: J
authors.lastname: Luo
authors.affiliation: Institute of Neurology, Huashan Hospital, Fudan University, WHO Collaborating Center for Research and Training in Neurosciences, Shanghai, China.
authors.forename: Lirong
authors.initials: L
authors.lastname: Yu
authors.affiliation: Institute of Neurology, Huashan Hospital, Fudan University, WHO Collaborating Center for Research and Training in Neurosciences, Shanghai, China.
authors.forename: Li
authors.initials: L
authors.lastname: Zheng
authors.affiliation: Institute of Neurology, Huashan Hospital, Fudan University, WHO Collaborating Center for Research and Training in Neurosciences, Shanghai, China.
authors.forename: Zhen
authors.initials: Z
authors.lastname: Hong
keywords: Aging; Conversion; Dementia; Mild cognitive impairment; Progression; Risk factor; prospective study