title: [Cancer genetic screening for patient with multiple renal tumors: What is the current practice for what results?].
abstract: OBJECTIVE
  To evaluate in a high volume center the practice and the performance of cancer genetic screening for patients with multiple renal tumors without a predisposition to kidney tumors known at the time of surgery.
  
  
  METHODS
  All patients treated for multiple renal tumors from January 2000 to December 2013 in our center were included. Patients with a family history of renal cell carcinoma, a kidney disease or a genetic predisposition to renal cancer known at the time of surgery were excluded from the analysis. Our list of patients was retrospectively compared to the records from PREDIR (PREDisposition to Kidney Tumors) center of Île-de-France, which regionally centralizes the care of patients with kidney tumors associated with a genetic predisposition.
  
  
  RESULTS
  One hundred and thirty-six patients were included. Twenty-six patients of 136 (19%) were referred to PREDIR center: 23 followed the screening and 3 did not show up in consultation. Of the 23 patients screened, three genetic predispositions to kidney tumors were identified (13%). Of the 95 patients with synchronous tumors, 48% with more than 3 tumors benefited from cancer genetics investigation against 13% of those presenting only two tumors.
  
  
  CONCLUSIONS
  Our study shows that cancer genetic investigations are not routinely offered to patients with multiple kidney tumors, conversely to existing guidelines. Urologists must be aware of this screening.
  
  
  METHODS
  4.
authors.affiliation: Service d'urologie, hôpital européen Georges-Pompidou, université Paris-Descartes (ParisV) , 20, rue Leblanc, 75015 Paris, France. Electronic address: aurelien.beaugerie@aphp.fr.
authors.forename: A
authors.initials: A
authors.lastname: Beaugerie
authors.affiliation: Service d'anatomie-pathologique, hôpital Necker-Enfants Malades, université Paris-Descartes (ParisV) , 75015 Paris, France.
authors.forename: V
authors.initials: V
authors.lastname: Verkarre
authors.affiliation: Service d'urologie, hôpital européen Georges-Pompidou, université Paris-Descartes (ParisV) , 20, rue Leblanc, 75015 Paris, France.
authors.forename: F
authors.initials: F
authors.lastname: Audenet
authors.affiliation: Service d'urologie, hôpital européen Georges-Pompidou, université Paris-Descartes (ParisV) , 20, rue Leblanc, 75015 Paris, France.
authors.forename: T
authors.initials: T
authors.lastname: Le Guilchet
authors.affiliation: Service d'urologie, hôpital européen Georges-Pompidou, université Paris-Descartes (ParisV) , 20, rue Leblanc, 75015 Paris, France.
authors.forename: S
authors.initials: S
authors.lastname: Hurel
authors.affiliation: Centre PREDIR, hôpital de Bicêtre, université Paris-Sud (Paris XIII) , 94270 Le Kremlin-Bicêtre, France.
authors.forename: S
authors.initials: S
authors.lastname: Richard
authors.affiliation: Service de radiologie adulte, hôpital Necker-Enfants Malades, université Paris-Descartes (ParisV) , 75015 Paris, France.
authors.forename: J M
authors.initials: JM
authors.lastname: Corréas
authors.affiliation: Service d'urologie, hôpital européen Georges-Pompidou, université Paris-Descartes (ParisV) , 20, rue Leblanc, 75015 Paris, France.
authors.forename: E
authors.initials: E
authors.lastname: Fontaine
authors.affiliation: Service d'urologie, hôpital européen Georges-Pompidou, université Paris-Descartes (ParisV) , 20, rue Leblanc, 75015 Paris, France.
authors.forename: A
authors.initials: A
authors.lastname: Méjean
authors.affiliation: Service d'urologie, hôpital européen Georges-Pompidou, université Paris-Descartes (ParisV) , 20, rue Leblanc, 75015 Paris, France.
authors.forename: M O
authors.initials: MO
authors.lastname: Timsit
mesh_terms: D055088:Early Detection of Cancer; D005260:Female; D005820:Genetic Testing; D006801:Humans; D007680:Kidney Neoplasms / Q000175:diagnosis* / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary / Q000175:diagnosis* / Q000235:genetics*; D012189:Retrospective Studies
keywords: Cancer genetic screening; Dépistage oncogénétique; Multiple tumors; Renal cell tumors; Tumeurs multiples; Tumeurs à cellules rénales