title: Different Alterations of Cerebral Regional Homogeneity in Early-Onset and Late-Onset Parkinson's Disease.
abstract: HIGHLIGHTS Eighteen EOPD, 21 LOPD and 37 age-matched normal control subjects participated in the resting state fMRI scans.Age at onset of PD modulates the distribution of cerebral regional homogeneity during resting state.Disproportionate putamen alterations are more prominent in PD patients with a younger age of onset.
  
  
  OBJECTIVE
  Early-onset Parkinson's disease (EOPD) is distinct from late-onset PD (LOPD) as it relates to the clinical profile and response to medication. The objective of current paper is to investigate whether characteristics of spontaneous brain activity in the resting state are associated with the age of disease onset.
  
  
  METHODS
  We assessed the correlation between neural activity and age-at-onset in a sample of 39 PD patients (18 EOPD and 21 LOPD) and 37 age-matched normal control subjects. Regional homogeneity (ReHo) approaches were employed using ANOVA with two factors: PD and age.
  
  
  RESULTS
  In the comparisons between LOPD and EOPD, EOPD revealed lower ReHo values in the right putamen and higher ReHo values in the left superior frontal gyrus. Compared with age-matched control subjects, EOPD exhibited lower ReHo values in the right putamen and higher ReHo values in the left inferior temporal gyrus; However, LOPD showed lower ReHo values in the right putamen and left insula. The ReHo values were negatively correlated with the UPDRS total scores in the right putamen in LOPD, but a correlation between the ReHo value and UPDRS score was not detected in EOPD.
  
  
  CONCLUSIONS
  Our findings support the notion that age at onset is associated with the distribution of cerebral regional homogeneity in the resting state and suggest that disproportionate putamen alterations are more prominent in patients with a younger age of onset.
authors.affiliation: Department of Internal Medicine, The University Hospital, Chongqing University Chongqing, China.
authors.forename: Ke
authors.initials: K
authors.lastname: Sheng
authors.affiliation: Department of Radiology, the First Affiliated Hospital, Chongqing Medical University Chongqing, China.
authors.forename: Weidong
authors.initials: W
authors.lastname: Fang
authors.affiliation: Department of Neurology, The First Affiliated Hospital, Chongqing Medical University Chongqing, China.
authors.forename: Yingcheng
authors.initials: Y
authors.lastname: Zhu
authors.affiliation: Department of Neurology, The First Affiliated Hospital, Chongqing Medical University Chongqing, China.
authors.forename: Guangying
authors.initials: G
authors.lastname: Shuai
authors.affiliation: Department of Neurology, The First Affiliated Hospital, Chongqing Medical University Chongqing, China.
authors.forename: Dezhi
authors.initials: D
authors.lastname: Zou
authors.affiliation: Department of Neurology, The First Affiliated Hospital, Chongqing Medical University Chongqing, China.
authors.forename: Meilan
authors.initials: M
authors.lastname: Su
authors.affiliation: Department of Neurology, The First Affiliated Hospital, Chongqing Medical University Chongqing, China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Han
authors.affiliation: Department of Neurology, The First Affiliated Hospital, Chongqing Medical University Chongqing, China.
authors.forename: Oumei
authors.initials: O
authors.lastname: Cheng
keywords: early-onset Parkinson's disease; late-onset Parkinson's disease; putamen; regional homogeneity; resting-state functional MRI