title: Copper-Catalyzed 2,2,2-Trifluoroethylthiolation of Aryl Halides.
abstract: Herein, a copper-catalyzed 2,2,2-trifluoroethylthiolation reaction of aryl bromides and iodides with elemental sulfur, and 1,1,1-trifluoro-2-iodoethane is described. The reaction showed excellent functional group tolerance and allowed the synthesis of various substituted aryl 2,2,2-trifluoroethyl thioethers with good to excellent yields. This transformation constitutes a one-pot synthesis of 2,2,2-trifluoroethylthiolated compounds from inexpensive, readily available starting materials. Utility of the protocol was further demonstrated in the late-stage synthesis of the pirfenidone derivative. The copper thiolate species were prepared and proposed as key intermediates in the catalytic cycle.
authors.affiliation: State Key Laboratory of Photocatalysis on Energy and Environment, College of Chemistry, Fuzhou University , Fujian, 350108, China.
authors.forename: Shouxiong
authors.initials: S
authors.lastname: Chen
authors.affiliation: State Key Laboratory of Photocatalysis on Energy and Environment, College of Chemistry, Fuzhou University , Fujian, 350108, China.
authors.forename: Mengjia
authors.initials: M
authors.lastname: Zhang
authors.affiliation: School of Pharmaceutical Sciences, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Tsinghua University , Beijing, 100084, China.
authors.forename: Xuebin
authors.initials: X
authors.lastname: Liao
authors.affiliation: State Key Laboratory of Photocatalysis on Energy and Environment, College of Chemistry, Fuzhou University , Fujian, 350108, China.
authors.forename: Zhiqiang
authors.initials: Z
authors.lastname: Weng