title: Green synthesized cerium oxide nanoparticle: A prospective drug against oxidative harm.
abstract: Cerium oxide nanoparticle (CeONP) of size 2-3nm was synthesized by a new, simple and green method at ambient temperature, using cerium nitrate as prime precursor and Aloe vera leaf extract as stabilizing agent. Of the two oxidation states (+3) and (+4) of cerium, it was dominantly present in (+3) state in CeONP and cyclic conversion of Ce(III)O→Ce(IV)O→Ce(III)O by reaction with H2O2 implied uninterrupted antioxidant property of CeONP. Moreover, the higher oxygen defect in the crystal lattice produced particles with higher antioxidant activity. CeONP was found to neutralize the deleterious effects of H2O2 viz., cell death, generation of intracellular reactive oxygen species and loss of connectivity in mouse neural cells. Therefore, CeONP might have potential use in future as an anti-oxidant drug.
authors.affiliation: Department of Biochemistry and Biophysics, University of Kalyani, Kalyani, 741235, West Bengal, India.
authors.forename: Debanjan
authors.initials: D
authors.lastname: Dutta
authors.affiliation: Department of Biochemistry and Biophysics, University of Kalyani, Kalyani, 741235, West Bengal, India.
authors.forename: Riya
authors.initials: R
authors.lastname: Mukherjee
authors.affiliation: Department of Biochemistry and Biophysics, University of Kalyani, Kalyani, 741235, West Bengal, India.
authors.forename: Mousumi
authors.initials: M
authors.lastname: Patra
authors.affiliation: Department of Biochemistry and Biophysics, University of Kalyani, Kalyani, 741235, West Bengal, India.
authors.forename: Milon
authors.initials: M
authors.lastname: Banik
authors.affiliation: Department of Biochemistry and Biophysics, University of Kalyani, Kalyani, 741235, West Bengal, India.
authors.forename: Rakhi
authors.initials: R
authors.lastname: Dasgupta
authors.affiliation: Saha Institute of Nuclear Physics, Kolkata, 700064, India.
authors.forename: Manabendra
authors.initials: M
authors.lastname: Mukherjee
authors.affiliation: Department of Biochemistry and Biophysics, University of Kalyani, Kalyani, 741235, West Bengal, India. Electronic address: tarakdb@yahoo.com.
authors.forename: Tarakdas
authors.initials: T
authors.lastname: Basu
mesh_terms: D000504:Aloe / Q000737:chemistry*; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D002470:Cell Survival / Q000187:drug effects; D002563:Cerium / Q000008:administration & dosage / Q000737:chemistry*; D006861:Hydrogen Peroxide / Q000494:pharmacology; D006863:Hydrogen-Ion Concentration; D051379:Mice; D053758:Nanoparticles / Q000008:administration & dosage / Q000737:chemistry*; D009447:Neuroblastoma / Q000188:drug therapy / Q000473:pathology*; D016877:Oxidants / Q000494:pharmacology; D010084:Oxidation-Reduction; D010936:Plant Extracts / Q000494:pharmacology*; D018515:Plant Leaves / Q000737:chemistry; D011446:Prospective Studies; D017382:Reactive Oxygen Species / Q000378:metabolism; D014407:Tumor Cells, Cultured
chemical_list: D000975:Antioxidants; D016877:Oxidants; D010936:Plant Extracts; D017382:Reactive Oxygen Species; D002563:Cerium; C030583:ceric oxide; D006861:Hydrogen Peroxide
keywords: Aloe-vera extract; Anti-oxidant activity; Cerium oxide nanoparticles; Green synthesis; Mouse neural cells