title: Lipid based delivery and immuno-stimulatory systems: Master tools to combat leishmaniasis.
abstract: Disease management of leishmaniasis is appalling due to lack of a human vaccine and the toxicity and resistance concerns with limited therapeutic drugs. The challenges in development of a safe vaccine for generation and maintenance of robust antileishmanial protective immunity through a human administrable route of immunization can be addressed through immunomodulation and targeted delivery. The versatility of lipid based particulate system for deliberate delivery of diverse range of molecules including immunomodulators, antigens and drugs have essentially found pivotal role in design of proficient vaccination and therapeutic strategies against leishmaniasis. The prospects of lipid based preventive and curative formulations for leishmaniasis have been highlighted in this review.
authors.affiliation: Infectious Diseases and Immunology Division, CSIR-Indian Institute of Chemical Biology, 4, Raja SC Mullick Road, Jadavpur, Kolkata 700032, West Bengal, India. Electronic address: absab2007@gmail.com.
authors.forename: Abdus
authors.initials: A
authors.lastname: Sabur
authors.affiliation: Infectious Diseases and Immunology Division, CSIR-Indian Institute of Chemical Biology, 4, Raja SC Mullick Road, Jadavpur, Kolkata 700032, West Bengal, India. Electronic address: asadseraphic.nii@gmail.com.
authors.forename: Mohammad
authors.initials: M
authors.lastname: Asad
authors.affiliation: Infectious Diseases and Immunology Division, CSIR-Indian Institute of Chemical Biology, 4, Raja SC Mullick Road, Jadavpur, Kolkata 700032, West Bengal, India. Electronic address: nali@iicb.res.in.
authors.forename: Nahid
authors.initials: N
authors.lastname: Ali
mesh_terms: D000276:Adjuvants, Immunologic; D000818:Animals; D016503:Drug Delivery Systems; D006801:Humans; D007114:Immunization; D007167:Immunotherapy / Q000379:methods* / Q000639:trends; D007896:Leishmaniasis / Q000276:immunology / Q000628:therapy*; D054332:Leishmaniasis Vaccines / Q000276:immunology*; D050356:Lipid Metabolism; D008055:Lipids
chemical_list: D000276:Adjuvants, Immunologic; D054332:Leishmaniasis Vaccines; D008055:Lipids
keywords: Adjuvant; Antigens; Delivery; Drugs; Emulsion; Immunomodulation; Immunotherapy; Leishmaniasis; Liposome; Vaccine