title: Stool DNA Analysis is Cost-Effective for Colorectal Cancer Surveillance in Patients With Ulcerative Colitis.
abstract: Patients with chronic ulcerative colitis are at increased risk for colorectal neoplasia (CRN). Surveillance by white-light endoscopy (WLE) or chromoendoscopy may reduce risk of CRN, but these strategies are underused. Analysis of DNA from stool samples (sDNA) can detect CRN with high levels of sensitivity, but it is not clear if this approach is cost-effective. We simulated these strategies for CRN detection to determine which approach is most cost-effective.
  
  
  
  We adapted a previously published Markov model to simulate the clinical course of chronic ulcerative colitis, the incidence of cancer or dysplasia, and costs and benefits of care with 4 surveillance strategies: (1) analysis of sDNA and diagnostic chromoendoscopy for patients with positive results, (2) analysis of sDNA with diagnostic WLE for patients with positive results, (3) chromoendoscopy with targeted collection of biopsies, or (4) WLE with random collection of biopsies. Costs were based on 2014 Medicare reimbursement. The primary outcome was the incremental cost-effectiveness ratio (incremental cost/incremental difference in quality-adjusted life-years) compared with no surveillance and a willingness-to-pay threshold of $50,000.
  
  
  
  All strategies fell below the willingness-to-pay threshold at 2-year intervals. Incremental cost-effectiveness ratios were $16,362 per quality-adjusted life-year for sDNA analysis with diagnostic chromoendoscopy; $18,643 per quality-adjusted life-year for sDNA analysis with diagnostic WLE; $23,830 per quality-adjusted life-year for chromoendoscopy alone; and $27,907 per quality-adjusted life-year for WLE alone. In sensitivity analyses, sDNA analysis with diagnostic chromoendoscopy was more cost-effective than chromoendoscopy alone, up to a cost of $1135 per sDNA test. sDNA analysis remained cost-effective at all rates of compliance; when combined with diagnostic chromoendoscopy, this approach was preferred over chromoendoscopy alone, when the specificity of the sDNA test for CRN was >65%.
  
  
  
  Based on a Markov model, surveillance for CRN is cost-effective for patients with chronic ulcerative colitis. Analysis of sDNA with chromoendoscopies for patients with positive results was more cost-effective than chromoendoscopy or WLE alone.
authors.affiliation: Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota. Electronic address: kisiel.john@mayo.edu.
authors.forename: John B
authors.initials: JB
authors.lastname: Kisiel
authors.affiliation: Division of Gastroenterology, Scripps Clinic, La Jolla, California; Scripps Translational Science Institute, La Jolla, California.
authors.forename: Gauree G
authors.initials: GG
authors.lastname: Konijeti
authors.affiliation: EmpiraQA LLC, Long Grove, Illinois.
authors.forename: Andrew J
authors.initials: AJ
authors.lastname: Piscitello
authors.affiliation: EmpiraQA LLC, Long Grove, Illinois.
authors.forename: Tarun
authors.initials: T
authors.lastname: Chandra
authors.affiliation: Boston Healthcare Associates, Boston, Massachusetts.
authors.forename: Thomas F
authors.initials: TF
authors.lastname: Goss
authors.affiliation: Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota.
authors.forename: David A
authors.initials: DA
authors.lastname: Ahlquist
authors.affiliation: Center for Digestive Disorders, Boston Medical Center, Section of Gastroenterology, Boston University School of Medicine, Boston, Massachusetts.
authors.forename: Francis A
authors.initials: FA
authors.lastname: Farraye
authors.affiliation: Division of Gastroenterology and Hepatology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts.
authors.forename: Ashwin N
authors.initials: AN
authors.lastname: Ananthakrishnan
mesh_terms: D003093:Colitis, Ulcerative / Q000150:complications*; D015179:Colorectal Neoplasms / Q000175:diagnosis*; D003362:Cost-Benefit Analysis; D004247:DNA / Q000032:analysis*; D055088:Early Detection of Cancer / Q000191:economics* / Q000379:methods*; D005243:Feces / Q000737:chemistry*; D006801:Humans
chemical_list: D004247:DNA
keywords: Cost Benefit Analysis; ICER; Inflammatory Bowel Diseases; QALY