title: Early surgery in Crohn's disease a benefit in selected cases.
abstract: OBJECTIVE
  To compare the outcomes of a cohort of Crohn's disease (CD) patients undergoing early surgery (ES) to those undergoing initial medical therapy (IMT).
  
  
  METHODS
  We performed a review of a prospective database CD patients managed at a single tertiary institution. Inclusion criteria were all patients with ileal or ileocolonic CD between 1995-2014. Patients with incomplete data, isolated colonic or perianal CD were excluded. Primary endpoints included the need for, and time to subsequent surgery. Secondary endpoints included the number and duration of hospital admissions, and medical therapy.
  
  
  RESULTS
  Forty-two patients underwent ES and 115 underwent IMT. The operative intervention rate at 5 years in the ES group was 14.2% vs IMT 31.3% (HR = 0.41, 95%CI: 0.23-0.72, P = 0.041). The ES group had fewer hospital admissions per patient [median 1 vs 3 (P = 0.012)] and fewer patients required anti-TNF therapy than IMT (33.3% vs 57%, P = 0.003). A subgroup analysis of 62 IMT patients who had undergone surgery were compared to ES patients, and showed similar 5 year (from index surgery) re-operation rates 16.1% vs 14.3%. In this subset, a significant difference was still found in median number of hospital admissions favouring ES, 1 vs 2 (P = 0.002).
  
  
  CONCLUSIONS
  Our data supports other recent studies suggesting that patients with ileocolonic CD may have a more benign disease course if undergoing early surgical intervention, with fewer admissions to hospital and a trend to reduced overall operation rates.
authors.affiliation: Vinna An, Lauren Cohen, Matthew Lawrence, Michelle Thomas, James Moore, Department of Colorectal Surgery, Royal Adelaide Hospital, Adelaide 5000, Australia.
authors.forename: Vinna
authors.initials: V
authors.lastname: An
authors.affiliation: Vinna An, Lauren Cohen, Matthew Lawrence, Michelle Thomas, James Moore, Department of Colorectal Surgery, Royal Adelaide Hospital, Adelaide 5000, Australia.
authors.forename: Lauren
authors.initials: L
authors.lastname: Cohen
authors.affiliation: Vinna An, Lauren Cohen, Matthew Lawrence, Michelle Thomas, James Moore, Department of Colorectal Surgery, Royal Adelaide Hospital, Adelaide 5000, Australia.
authors.forename: Matthew
authors.initials: M
authors.lastname: Lawrence
authors.affiliation: Vinna An, Lauren Cohen, Matthew Lawrence, Michelle Thomas, James Moore, Department of Colorectal Surgery, Royal Adelaide Hospital, Adelaide 5000, Australia.
authors.forename: Michelle
authors.initials: M
authors.lastname: Thomas
authors.affiliation: Vinna An, Lauren Cohen, Matthew Lawrence, Michelle Thomas, James Moore, Department of Colorectal Surgery, Royal Adelaide Hospital, Adelaide 5000, Australia.
authors.forename: Jane
authors.initials: J
authors.lastname: Andrews
authors.affiliation: Vinna An, Lauren Cohen, Matthew Lawrence, Michelle Thomas, James Moore, Department of Colorectal Surgery, Royal Adelaide Hospital, Adelaide 5000, Australia.
authors.forename: James
authors.initials: J
authors.lastname: Moore
keywords: Crohn’s disease; Inflammatory bowel disease; Operation; Surgery; Terminal ileitis