title: Irritable bowel syndrome, the microbiota and the gut-brain axis.
abstract: Irritable bowel syndrome is a common functional gastrointestinal disorder and it is now evident that irritable bowel syndrome is a multi-factorial complex of changes in microbiota and immunology. The bidirectional neurohumoral integrated communication between the microbiota and the autonomous nervous system is called the gut-brain-axis, which integrates brain and GI functions, such as gut motility, appetite and weight. The gut-brain-axis has a central function in the perpetuation of irritable bowel syndrome and the microbiota plays a critical role. The purpose of this article is to review recent research concerning the epidemiology of irritable bowel syndrome, influence of microbiota, probiota, gut-brain-axis, and possible treatment modalities on irritable bowel syndrome.
authors.affiliation: a Speciallægecentret ved Diakonissestiftelsen , Frederiksberg , Denmark.
authors.forename: Hans
authors.initials: H
authors.lastname: Raskov
authors.affiliation: b Department of Surgery , Zealand University Hospital, University of Copenhagen, Copenhagen , Denmark.|c Centre for Perioperative Optimization, Herlev Hospital, University of Copenhagen , Copenhagen , Denmark.
authors.forename: Jakob
authors.initials: J
authors.lastname: Burcharth
authors.affiliation: c Centre for Perioperative Optimization, Herlev Hospital, University of Copenhagen , Copenhagen , Denmark.|d Department of Surgery , Hvidovre Hospital, University of Copenhagen , Copenhagen , Denmark.
authors.forename: Hans-Christian
authors.initials: HC
authors.lastname: Pommergaard
authors.affiliation: c Centre for Perioperative Optimization, Herlev Hospital, University of Copenhagen , Copenhagen , Denmark.
authors.forename: Jacob
authors.initials: J
authors.lastname: Rosenberg
mesh_terms: D000818:Animals; D001921:Brain / Q000503:physiopathology*; D000069196:Gastrointestinal Microbiome; D041981:Gastrointestinal Tract / Q000382:microbiology / Q000503:physiopathology*; D006801:Humans; D043183:Irritable Bowel Syndrome / Q000382:microbiology* / Q000503:physiopathology
keywords: gut-brain axis; irritable bowel syndrome; microbiota