title: Strategies for bioengineered scaffolds that support adipose stem cells in regenerative therapies.
abstract: Regenerative medicine possesses the potential to ameliorate damage to tissue that results from a vast range of conditions, including traumatic injury, tumor resection and inherited tissue defects. Adult stem cells, while more limited in their potential than pluripotent stem cells, are still capable of differentiating into numerous lineages and provide feasible allogeneic and autologous treatment options for many conditions. Adipose stem cells are one of the most abundant types of stem cell in the adult human. Here, we review recent advances in the development of synthetic scaffolding systems used in concert with adipose stem cells and assess their potential use for clinical applications.
authors.affiliation: Center for Stem Cell Biology & Engineering, University of California, Santa Barbara, CA, USA.|Neuroscience Research Institute, University of California, Santa Barbara, CA, USA.|Department of Molecular, Cellular & Developmental Biology, University of California, Santa Barbara, CA, USA.|Institute for Collaborative Biotechnologies, University of California, Santa Barbara, CA, USA.
authors.forename: Tracy N
authors.initials: TN
authors.lastname: Clevenger
authors.affiliation: Neuroscience Research Institute, University of California, Santa Barbara, CA, USA.|Center for Bio-Image Informatics, University of California, Santa Barbara, CA, USA.
authors.forename: Gabriel
authors.initials: G
authors.lastname: Luna
authors.affiliation: Neuroscience Research Institute, University of California, Santa Barbara, CA, USA.|Center for Bio-Image Informatics, University of California, Santa Barbara, CA, USA.
authors.forename: Steven K
authors.initials: SK
authors.lastname: Fisher
authors.affiliation: Center for Stem Cell Biology & Engineering, University of California, Santa Barbara, CA, USA.|Neuroscience Research Institute, University of California, Santa Barbara, CA, USA.|Department of Molecular, Cellular & Developmental Biology, University of California, Santa Barbara, CA, USA.|Institute for Collaborative Biotechnologies, University of California, Santa Barbara, CA, USA.
authors.forename: Dennis O
authors.initials: DO
authors.lastname: Clegg
mesh_terms: D000273:Adipose Tissue / Q000166:cytology* / Q000637:transplantation; D000818:Animals; D064987:Cell- and Tissue-Based Therapy; D006801:Humans; D012038:Regeneration / Q000502:physiology*; D033581:Stem Cell Transplantation; D013234:Stem Cells / Q000166:cytology*; D023822:Tissue Engineering / Q000379:methods*; D054457:Tissue Scaffolds
keywords: 3D scaffolds; ASC; adipose-derived stem cells; cartilaginous regeneration; osteogenic regeneration; regenerative medicine; soft-tissue regeneration; synthetic scaffold