title: Maxillofacial Changes in Melnick-Needles Syndrome.
abstract: Background. Melnick-Needles Syndrome is rare congenital hereditary skeletal dysplasia caused by mutations in the FLNA gene, which codifies the protein filamin A. This condition leads to serious skeletal abnormalities, including the stomatognathic region. Case Presentation. This paper describes the case of a 13-year-old girl diagnosed with Melnick-Needles Syndrome presenting with different forms of skeletal dysplasia, such as cranial hyperostosis, short upper limbs, bowed long bones, metaphyseal thickening, genu valgum (knock-knee), shortened distal phalanges, narrow pelvis and shoulders, rib tapering and irregularities, elongation of the vertebrae, kyphoscoliosis, micrognathia, hypoplastic coronoid processes of the mandible, left stylohyoid ligament suggesting ossification, and dental development anomalies. Conclusion. Knowledge of this rare syndrome on the part of dentists is important due to the fact that this condition involves severe abnormalities of the stomatognathic system that cause an impact on the development of the entire face as well as functional and esthetic impairments.
authors.affiliation: Brazilian Association of Dentistry, 57037-240 Maceió, AL, Brazil.
authors.forename: Leilane Larissa
authors.initials: LL
authors.lastname: Albuquerque do Nascimento
authors.affiliation: Postgraduate Program in Biophotonics Applied to Health Sciences, Nove de Julho University, 01504-001 São Paulo, SP, Brazil.
authors.forename: Monica da Consolação Canuto
authors.initials: Mda C
authors.lastname: Salgueiro
authors.affiliation: Brazilian Association of Dentistry, 57037-240 Maceió, AL, Brazil.
authors.forename: Mariana
authors.initials: M
authors.lastname: Quintela
authors.affiliation: Nove de Julho University, 01504-001 São Paulo, SP, Brazil.
authors.forename: Victor Perez
authors.identifier: 0000-0003-2726-157X
authors.initials: VP
authors.lastname: Teixeira
authors.affiliation: Postgraduate Program in Biophotonics Applied to Health Sciences, Nove de Julho University, 01504-001 São Paulo, SP, Brazil.
authors.forename: Ana Carolina Costa
authors.initials: AC
authors.lastname: Mota
authors.affiliation: Postgraduate Program in Rehabilitation Sciences, Nove de Julho University, 01504-001 São Paulo, SP, Brazil.
authors.forename: Camila Haddad Leal
authors.identifier: 0000-0002-0035-8008
authors.initials: CH
authors.lastname: de Godoy
authors.affiliation: Postgraduate Program in Biophotonics Applied to Health Sciences, Nove de Julho University, 01504-001 São Paulo, SP, Brazil; Postgraduate Program in Rehabilitation Sciences, Nove de Julho University, 01504-001 São Paulo, SP, Brazil.
authors.forename: Sandra Kalil
authors.identifier: 0000-0002-9853-1138
authors.initials: SK
authors.lastname: Bussadori