title: An arsenal of magnetic nanoparticles; perspectives in the treatment of cancer.
abstract: Nanomedicine is an emerging field, which constitutes a new direction in the treatment of cancer. Magnetic nanoparticles (MNPs) can circumvent vascular tissue to concentrate at the site of the tumor. Under the influence of an external, alternating magnetic field, MNPs generate high temperatures within the tumor and ablate malignant cells while inflicting minimal damage to healthy host tissue. Due to their theranostic properties, they constitute a promising candidate for the treatment of cancer. A critical review of the type, size and therapeutic effect of different MNPs is presented, following an appraisal of the literature in the last 5 years. This is a multibillion dollar industry, with a few studies moving to clinical trials within the next 5 years.
authors.affiliation: School of Medicine, Imperial College London, London, UK.
authors.forename: Dimitrios
authors.initials: D
authors.lastname: Karponis
authors.affiliation: School of Healthcare Science, Faculty of Science & Engineering, Manchester Metropolitan University, Manchester, UK.
authors.forename: May
authors.initials: M
authors.lastname: Azzawi
authors.affiliation: Center for Nanotechnology & Regenerative Medicine, University College London, London, UK.|NanoRegMed Ltd, The London BioScience Innovation Center, London, UK.
authors.forename: Alexander
authors.initials: A
authors.lastname: Seifalian
mesh_terms: D000818:Animals; D006801:Humans; D006979:Hyperthermia, Induced / Q000379:methods*; D058185:Magnetite Nanoparticles / Q000737:chemistry / Q000627:therapeutic use* / Q000648:ultrastructure; D050997:Nanomedicine / Q000379:methods*; D036103:Nanotechnology / Q000379:methods*; D009369:Neoplasms / Q000473:pathology / Q000628:therapy*
chemical_list: D058185:Magnetite Nanoparticles
keywords: breast cancer; cancer; hyperthermia; iron nanoparticles; lung cancer; magnetic nanoparticles; nanomaterial; nanotechnology; superparamagnetic nanoparticles