title: LncRNA RSU1P2 contributes to tumorigenesis by acting as a ceRNA against let-7a in cervical cancer cells.
abstract: Long non-coding RNAs (lncRNAs) can regulate gene expression at different levels and are widely participate in various physiological and pathological processes. Emerging evidences suggests that a number of differentially expressed lncRNAs are involved in tumorigenesis. However, the function and expression regulation of a vast majority of these unique RNAs is little known. Here, we found that the lncRNA Ras suppressor protein 1 pseudogene 2 (RSU1P2) is upregulateded in cervical cancer tissues and has a tumour-promoting role. We revealed that RSU1P2 acts as a competitive endogenous RNA (ceRNA) through regulating the expression of IGF1R, N-myc and EphA4. The mechanism of this regulation is via competition for the shared microRNA let-7a. This competition promotes the malignant phenotype of cervical carcinoma cells. The transcription factor N-myc forms a positive feedback loop with RSU1P2 by in turn activating its expression, thereby enhancing its oncogenic capacity. Hence, cancer-selective targeting of RSU1P2 could have strong benefits.
authors.affiliation: Tianjin Life Science Research Center, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, China.
authors.forename: Qian
authors.initials: Q
authors.lastname: Liu
authors.affiliation: Tianjin Life Science Research Center, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, China.
authors.forename: Xu
authors.initials: X
authors.lastname: Guo
authors.affiliation: Tianjin Life Science Research Center, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, China.
authors.forename: Shengshun
authors.initials: S
authors.lastname: Que
authors.affiliation: Tianjin Life Science Research Center, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, China.
authors.forename: Xi
authors.initials: X
authors.lastname: Yang
authors.affiliation: Tianjin Life Science Research Center, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, China.
authors.forename: Hongxia
authors.initials: H
authors.lastname: Fan
authors.affiliation: Tianjin Life Science Research Center, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, China.
authors.forename: Min
authors.initials: M
authors.lastname: Liu
authors.affiliation: Tianjin Life Science Research Center, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Li
authors.affiliation: Tianjin Life Science Research Center, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, China.
authors.forename: Hua
authors.initials: H
authors.lastname: Tang
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000235:genetics; D002453:Cell Cycle / Q000235:genetics; D045744:Cell Line, Tumor; D002471:Cell Transformation, Neoplastic / Q000235:genetics*; D004195:Disease Models, Animal; D058750:Epithelial-Mesenchymal Transition / Q000235:genetics; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D064593:Heterografts; D006801:Humans; D051379:Mice; D035683:MicroRNAs / Q000235:genetics*; D034622:RNA Interference; D062085:RNA, Long Noncoding / Q000235:genetics*; D047368:Tumor Burden; D002583:Uterine Cervical Neoplasms / Q000235:genetics* / Q000473:pathology
chemical_list: D035683:MicroRNAs; D062085:RNA, Long Noncoding; C487931:mirnlet7 microRNA, human
keywords: Let-7; N-myc; ceRNA; lnc-RNA; miRNA