title: Association of dental and periodontal disease with chronic kidney disease in patients of a single, tertiary care centre in Thailand.
abstract: Several studies have shown an association between oral diseases and chronic kidney disease (CKD), and regular oral care may be an important strategy for reducing the burden of CKD. The objective of this study was therefore to evaluate the association between dental and periodontal diseases in Thai patients with various stages of CKD.
  
  
  
  This was designed as a cross-sectional study and was performed between 2011 and 2012. The inclusion criteria were age >20 years and a diagnosis of CKD for at least 90 days. Data from medical records were collected, clinical oral examination was performed, and data were statistically analysed.
  
  
  
  A total of 129 patients with different stages of CKD were included. Ninety-eight (76%) were men. The age range was 30-86 years. The Decay, Missing and Filling Tooth Index and the number of missing teeth were higher in the group with moderate CKD than in the control group (21 vs 17.5, p=0.045, 13 vs 8 p=0.01, respectively). Serum albumin levels decreased when estimated glomerular filtration rate (eGFR) was in decline (γ=0.33; p=0.002). Severe periodontitis was significantly higher in the 'more severe CKD group' (eGFR <60 mL/min/1.73 m(2)) than in the 'less severe CKD group' (eGFR 60-90 mL/min/1.73 m(2); 24% vs 9%, p=0.03). Severe periodontitis, eGFR <30 mL/min/1.73 m(2) and brushing teeth more than once a day were associated with hypoalbuminaemia (defined as <3.8 g/dL) (OR (95% CI) 5.88 (1.64 to 21.11), 5.80 (1.58 to 21.35) and 0.16 (0.05 to 0.60), respectively).
  
  
  
  Severe periodontal diseases were more prevalent in patients with more severe CKD than in those with less severe CKD. The novel association of serum albumin levels with periodontal status was demonstrated in progressive stages of CKD. Dental intervention may be beneficial from the early stages of CKD.
authors.affiliation: Medicine Division, Medical Department, Golden Jubilee Medical Center, Mahidol University, Nakhon Pathom, Thailand.
authors.forename: R
authors.initials: R
authors.lastname: Ausavarungnirun
authors.affiliation: Department of Oral and Maxillofacial Radiology, Faculty of Dentistry, Mahidol University, Bangkok, Thailand.
authors.forename: S
authors.initials: S
authors.lastname: Wisetsin
authors.affiliation: Medicine Division, Medical Department, Golden Jubilee Medical Center, Mahidol University, Nakhon Pathom, Thailand.
authors.forename: N
authors.initials: N
authors.lastname: Rongkiettechakorn
authors.affiliation: Department of Oral Medicine and Periodontics, Faculty of Dentistry, Mahidol University, Bangkok, Thailand.
authors.forename: S
authors.initials: S
authors.lastname: Chaichalermsak
authors.affiliation: Medicine Department, Saraburi Hospital, Muang, Saraburi, Thailand.
authors.forename: U
authors.initials: U
authors.lastname: Udompol
authors.affiliation: Medicine Division, Medical Department, Golden Jubilee Medical Center, Mahidol University, Nakhon Pathom, Thailand.
authors.forename: M
authors.initials: M
authors.lastname: Rattanasompattikul
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D034141:Hypoalbuminemia / Q000097:blood*; D008297:Male; D008875:Middle Aged; D010510:Periodontal Diseases / Q000453:epidemiology*; D015995:Prevalence; D051436:Renal Insufficiency, Chronic / Q000453:epidemiology*; D012307:Risk Factors; D012720:Severity of Illness Index; D062606:Tertiary Care Centers / Q000706:statistics & numerical data; D013785:Thailand / Q000453:epidemiology
keywords: Chronic kidney disease; Complications of chronic kidney disease; Dental disease; Hypoalbuminemia; Periodontal disease