title: Mitochondrial redox system, dynamics, and dysfunction in lung inflammaging and COPD.
abstract: Myriad forms of endogenous and environmental stress disrupt mitochondrial function by impacting critical processes in mitochondrial homeostasis, such as mitochondrial redox system, oxidative phosphorylation, biogenesis, and mitophagy. External stressors that interfere with the steady state activity of mitochondrial functions are generally associated with an increase in reactive oxygen species, inflammatory response, and induction of cellular senescence (inflammaging) potentially via mitochondrial damage associated molecular patterns (DAMPS). Many of these are the key events in the pathogenesis of chronic obstructive pulmonary disease (COPD) and its exacerbations. In this review, we highlight the primary mitochondrial quality control mechanisms that are influenced by oxidative stress/redox system, including role of mitochondria during inflammation and cellular senescence, and how mitochondrial dysfunction contributes to the pathogenesis of COPD and its exacerbations via pathogenic stimuli.
authors.affiliation: Department of Environmental Medicine, Lung Biology and Disease Program, University of Rochester Medical Center, Rochester, NY, USA.
authors.forename: Chad A
authors.initials: CA
authors.lastname: Lerner
authors.affiliation: Department of Environmental Medicine, Lung Biology and Disease Program, University of Rochester Medical Center, Rochester, NY, USA.
authors.forename: Isaac K
authors.initials: IK
authors.lastname: Sundar
authors.affiliation: Department of Environmental Medicine, Lung Biology and Disease Program, University of Rochester Medical Center, Rochester, NY, USA. Electronic address: irfan_rahman@urmc.rochester.edu.
authors.forename: Irfan
authors.initials: I
authors.lastname: Rahman
mesh_terms: D006801:Humans; D008168:Lung / Q000276:immunology / Q000503:physiopathology*; D008928:Mitochondria / Q000378:metabolism* / Q000473:pathology*; D010084:Oxidation-Reduction; D018384:Oxidative Stress; D029424:Pulmonary Disease, Chronic Obstructive / Q000503:physiopathology*; D017382:Reactive Oxygen Species
chemical_list: D017382:Reactive Oxygen Species
keywords: Cellular senescence; DAMPs; Inflammation; Mitophagy; Oxidative phosphorylation; Redox; Telomere