title: An analysis of autopsy cases of non-Hodgkin lymphoma-with special reference to those masquerading as acute febrile illness.
abstract: BACKGROUND
  As in any medical disorder, in non-Hodgkin lymphomas (NHLs) also, precise analysis of causes of death is needed to focus research efforts and improve morbidity and mortality.
  
  
  OBJECTIVE
  The aim of this study was to review the clinical presentation, mode of death and the immunophenotype of the autopsy cases of NHL.
  
  
  METHODS
  Autopsy cases wherein NHL was diagnosed, were selected for study.
  
  
  METHODS
  Autopsy cases which were diagnosed as NHL, either antemortem or after autopsy during a 7 years period at a tertiary care referral centre were studied and reviewed.
  
  
  METHODS
  Descriptive statistical analysis used.
  
  
  RESULTS
  The autopsy findings seen in eight cases of NHL were reviewed. Except one, all cases were above 40 years age. Infective etiology (62%) followed by cardiorespiratory failure (38%) was the cause of death observed in these patients. In three cases, the antemortem diagnosis of NHL was missed as the patients were being treated for acute febrile illness and were referred late to the Tertiary Care Centre. One of these was a case of extra-nodal primary splenic lymphoma.
  
  
  CONCLUSIONS
  As NHL present with nonspecific symptoms, these tumours may not be detected in early stages and hence may not be treated appropriately. These patients have weakened immunity and hence are prone to infection and sepsis which can be a major cause of mortality. This autopsy study experience has shown that NHL can masquerade as acute febrile illness which if not detected early and treated adequately can turn fatal.
authors.affiliation: Department of Pathology, Lokmanya Tilak Municipal Medical College, Mumbai, Maharashtra, India.
authors.forename: Sonali Rajesh
authors.initials: SR
authors.lastname: Saraf
authors.affiliation: Department of Pathology, Lokmanya Tilak Municipal Medical College, Mumbai, Maharashtra, India.
authors.forename: Nilesh S
authors.initials: NS
authors.lastname: Naphade
authors.affiliation: Department of Pathology, Lokmanya Tilak Municipal Medical College, Mumbai, Maharashtra, India.
authors.forename: Alka D
authors.initials: AD
authors.lastname: Kalgutkar
mesh_terms: D000328:Adult; D001344:Autopsy; D002423:Cause of Death; D005260:Female; D005334:Fever / Q000175:diagnosis* / Q000209:etiology; D006801:Humans; D008198:Lymph Nodes / Q000473:pathology; D008228:Lymphoma, Non-Hodgkin / Q000175:diagnosis* / Q000209:etiology; D008297:Male; D008875:Middle Aged; D064847:Multimodal Imaging; D055815:Young Adult