title: The human gut microbiome of Latin America populations: a landscape to be discovered.
abstract: The gut microbiome is critical for human health, and its alteration is associated with intestinal, autoimmune and metabolic diseases. Numerous studies have focused on prevention or treatment of dysbiotic microbiome to reduce the risk or effect of these diseases. A key issue is to define the microbiome associated with the state of good health. The purpose of this review is to describe factors influencing the gut microbiome with special emphasis on contributions from Latin America. In addition, we will highlight opportunities for future studies on gut microbiome in Latin America.
  
  
  
  A relevant factor influencing gut microbiome composition is geographical location associated with specific genetic, dietary and lifestyle factors. Geographical specificities suggest that a universal 'healthy microbiome' is unlikely.
  
  
  
  Several research programs, mostly from Europe and North America, are extensively sequencing gut microbiome of healthy people, whereas data from Latin America remain scarce yet slowly increasing. Few studies have shown difference in the composition of gut microbiome between their local populations with that of other industrialized countries (North American populations). Latin America is composed of countries with a myriad of lifestyles, traditions, genetic backgrounds and socioeconomic conditions, which may determine differences in gut microbiome of individuals from different countries. This represents an opportunity to better understand the relationship between these factors and gut microbiome.
authors.affiliation: aMicrobiology and Mycology Program, ICBM bDepartment of Pediatrics, Center of Molecular Studies, Faculty of Medicine, University of Chile, Santiago, Chile.
authors.forename: Fabien
authors.initials: F
authors.lastname: Magne
authors.forename: Miguel L
authors.initials: ML
authors.lastname: O'Ryan
authors.forename: Roberto
authors.initials: R
authors.lastname: Vidal
authors.forename: Mauricio
authors.initials: M
authors.lastname: Farfan
mesh_terms: D064806:Dysbiosis; D000069196:Gastrointestinal Microbiome; D006801:Humans; D015212:Inflammatory Bowel Diseases; D007843:Latin America; D008019:Life Style; D009765:Obesity