title: Correlative study of peripheral ATP1A1 gene expression level to anxiety severity score on major depressive disorder patients.
abstract: BACKGROUND
  Major depressive disorder (MDD) frequently co-occurs with other psychiatric problems. Our previous study showed that ATP1A1 gene expression level was significantly decreased in MDD patients. This research explores the potential correlations between the ATP1A1 expression level reduction and MDD patients' clinical manifestation.
  
  
  METHODS
  All participant patients were diagnosed by Diagnostic and Statistical Manual of Mental Disorders - 4th edition (DSM-IV). Hamilton rating scale for depression (HAM-D) and anxiety (HAM-A) were applied to group patients into different categories. ATP1A1 expression level was measured by reverse transcript real-time polymerase chain reaction.
  
  
  RESULTS
  ATP1A1 expression levels of all MDD subgroups showed significant reduction compared to the control group (p<0.01). Further, the trend of ATP1A1 expression level reduction is significantly related to MDD patients' HAM-A scores (p<0.01). However, there was no significance between ATP1A1 level and HAM-D scores (p>0.05).
  
  
  CONCLUSIONS
  ATP1A1 expression level reduction is related to MDD anxiety score, which may be an explanation for the clinical manifestations and the underlining physiological mechanisms.
authors.forename: Jingjie
authors.initials: J
authors.lastname: Zhao
authors.forename: Xu
authors.initials: X
authors.lastname: Guo
authors.forename: Yi
authors.initials: Y
authors.lastname: Du
authors.forename: Yu
authors.initials: Y
authors.lastname: Han
authors.forename: Yongzhi
authors.initials: Y
authors.lastname: Wang
authors.forename: Li
authors.initials: L
authors.lastname: Li
authors.forename: Jialin
authors.initials: J
authors.lastname: Qian
authors.forename: Mingzhen
authors.initials: M
authors.lastname: Li
authors.forename: Huijuan
authors.initials: H
authors.lastname: Wu
authors.forename: Teresa
authors.initials: T
authors.lastname: Golden
authors.forename: Ning
authors.initials: N
authors.lastname: Wu
mesh_terms: D000328:Adult; D001007:Anxiety / Q000175:diagnosis* / Q000235:genetics / Q000378:metabolism*; D003865:Major Depressive Disorder / Q000175:diagnosis* / Q000235:genetics / Q000378:metabolism*; D005260:Female; D005786:Gene Expression Regulation; D006801:Humans; D008297:Male; D008875:Middle Aged; D012720:Severity of Illness Index; D000254:Sodium-Potassium-Exchanging ATPase / Q000096:biosynthesis* / Q000235:genetics
chemical_list: C499076:ATP1A1 protein, human; D000254:Sodium-Potassium-Exchanging ATPase