title: Polymorphisms in Inflammatory Mediator Genes and Risk of Preeclampsia in Taiyuan, China.
abstract: Excessive maternal inflammatory response is involved in the pathogenesis of preeclampsia. Few epidemiologic studies have investigated the associations between genetic variations in the inflammatory mediator genes and preeclampsia risk, and these studies have reached inconsistent results. We examined 31 single-nucleotide polymorphisms in IL-1A, IL-1B, IL-1R1, IL-2RA, IL-5RA, IL-6, IL-6R, TNFSF11, TNFRSF11A, IL-28RA, IRAK4, and KIT genes and the risk of preeclampsia and its clinical subtypes in a nested case-control study including 203 preeclampsia cases and 233 controls. We found that IL-1R1, IL-5RA, IL-6R, and TNFSF11 were associated with the risk of preeclampsia. Although the significant associations observed for preeclampsia overall were mainly seen for late-onset preeclampsia and severe preeclampsia, IL-6R (rs2229238) and TNFSF11 (rs9525643) polymorphisms were associated with the risk of early-onset preeclampsia. TNFSF11 (rs2200287 and rs2148072) polymorphisms were associated with risk of mild preeclampsia. Our study provided the first evidence that genetic variations in inflammatory mediator genes IL-1R1, IL-6R, TNFSF11, and IL-5RA were associated with preeclampsia risk, and the risk varied by preeclampsia subtypes.
authors.affiliation: 1 Department of Epidemiology, Shanxi Medical University School of Public Health, Taiyuan, China.
authors.forename: Weiwei
authors.initials: W
authors.lastname: Wu
authors.affiliation: 2 Department of Obstetrics, the First Affiliated Hospital, Shanxi Medical University, Taiyuan, China.
authors.forename: Hailan
authors.initials: H
authors.lastname: Yang
authors.affiliation: 1 Department of Epidemiology, Shanxi Medical University School of Public Health, Taiyuan, China.
authors.forename: Yongliang
authors.initials: Y
authors.lastname: Feng
authors.affiliation: 1 Department of Epidemiology, Shanxi Medical University School of Public Health, Taiyuan, China.
authors.forename: Ping
authors.initials: P
authors.lastname: Zhang
authors.affiliation: 3 Department of Information, the First Affiliated Hospital, Shanxi Medical University, Taiyuan, China.
authors.forename: Shuzhen
authors.initials: S
authors.lastname: Li
authors.affiliation: 4 Center For Disease Control and Prevention, Taiyuan Railway Administration, Taiyuan, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Wang
authors.affiliation: 1 Department of Epidemiology, Shanxi Medical University School of Public Health, Taiyuan, China.
authors.forename: Tingting
authors.initials: T
authors.lastname: Peng
authors.affiliation: 1 Department of Epidemiology, Shanxi Medical University School of Public Health, Taiyuan, China.
authors.forename: Fang
authors.initials: F
authors.lastname: Wang
authors.affiliation: 1 Department of Epidemiology, Shanxi Medical University School of Public Health, Taiyuan, China.
authors.forename: Bingjie
authors.initials: B
authors.lastname: Xie
authors.affiliation: 1 Department of Epidemiology, Shanxi Medical University School of Public Health, Taiyuan, China.
authors.forename: Pengge
authors.initials: P
authors.lastname: Guo
authors.affiliation: 1 Department of Epidemiology, Shanxi Medical University School of Public Health, Taiyuan, China.
authors.forename: Mei
authors.initials: M
authors.lastname: Li
authors.affiliation: 1 Department of Epidemiology, Shanxi Medical University School of Public Health, Taiyuan, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Wang
authors.affiliation: 5 Department of Environmental Health Sciences, Yale School of Public Health, New Haven, CT, USA.
authors.forename: Nan
authors.initials: N
authors.lastname: Zhao
authors.affiliation: 1 Department of Epidemiology, Shanxi Medical University School of Public Health, Taiyuan, China.
authors.forename: Suping
authors.initials: S
authors.lastname: Wang
authors.affiliation: 1 Department of Epidemiology, Shanxi Medical University School of Public Health, Taiyuan, China.|5 Department of Environmental Health Sciences, Yale School of Public Health, New Haven, CT, USA.
authors.forename: Yawei
authors.initials: Y
authors.lastname: Zhang
mesh_terms: D000328:Adult; D000483:Alleles; D016022:Case-Control Studies; D002681:China; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D007378:Interleukins / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D011225:Pre-Eclampsia / Q000235:genetics*; D011247:Pregnancy; D019009:Proto-Oncogene Proteins c-kit / Q000235:genetics*; D055815:Young Adult
chemical_list: D007378:Interleukins; D019009:Proto-Oncogene Proteins c-kit
keywords: IL-1R1; IL-5RA; genetic polymorphisms; inflammatory mediator gene; preeclampsia