title: Mild Cognitive Impairment in Patients with Early-Onset Parkinson's Disease.
abstract: Few studies have described mild cognitive impairment (MCI) and cognitive characteristics in early-onset Parkinson's disease (EOPD). This study describes attention/working memory, language, memory, visuospatial abilities, executive function, and frequency of MCI and dementia in EOPD.
  
  
  
  Eighty-one EOPD patients were administered neuropsychological tests and the Beck Depression Inventory. Scores were compared with age/education-appropriate norms and were correlated to years of disease progression and severity of motor symptoms. The frequency of MCI and dementia was determined by the Movement Disorder Society criteria.
  
  
  
  Thirty-one percent of patients met the MCI criteria, but none had dementia. Commonly affected domains were memory, visuospatial, and executive function. Cognitive dysfunction was not explained by depression or severity of motor symptoms.
  
  
  
  One third of EOPD patients presented with MCI, which was not associated with the same risk factors as reported in late-onset Parkinson's disease. MCI could have a different prognostic value in EOPD.
authors.affiliation: Interdisciplinary Investigation Unit in Health and Education Sciences, Master in Psychology, Clinical Neuropsychology Residency Program, FES Iztacala, Universidad Nacional Autónoma de México, Mexico City, Mexico.
authors.forename: Ana Natalia
authors.initials: AN
authors.lastname: Seubert-Ravelo
authors.forename: M Guillermina
authors.initials: MG
authors.lastname: Yáñez-Téllez
authors.forename: Hermelinda
authors.initials: H
authors.lastname: Salgado-Ceballos
authors.forename: Rodrigo Erick
authors.initials: RE
authors.lastname: Escartín-Pérez
authors.forename: Gabriel Adolfo
authors.initials: GA
authors.lastname: Neri-Nani
authors.forename: Salvador
authors.initials: S
authors.lastname: Velázquez-Osuna
mesh_terms: D017668:Age of Onset; D000368:Aged; D000377:Agnosia / Q000175:diagnosis / Q000453:epidemiology; D060825:Cognitive Dysfunction / Q000175:diagnosis / Q000453:epidemiology / Q000503:physiopathology / Q000523:psychology; D003704:Dementia / Q000175:diagnosis / Q000453:epidemiology; D003863:Depression / Q000175:diagnosis / Q000453:epidemiology; D018450:Disease Progression; D056344:Executive Function; D005260:Female; D006801:Humans; D008297:Male; D008570:Memory, Short-Term; D009483:Neuropsychological Tests; D010300:Parkinson Disease / Q000175:diagnosis / Q000453:epidemiology / Q000503:physiopathology / Q000523:psychology; D011569:Psychiatric Status Rating Scales; D012307:Risk Factors; D013223:Statistics as Topic