title: Associations between functional FCGR2A R131H and FCGR3A F158V polymorphisms and responsiveness to TNF blockers in spondyloarthropathy, psoriasis and Crohn's disease: a meta-analysis.
abstract: The aim of the current study was to investigate whether FCGR polymorphisms are associated with responsiveness to anti-TNF-α therapy in patients with spondyloarthropathy, psoriasis, and Crohn's disease.
  
  
  
  We conducted a meta-analysis to evaluate the association between the functional FCGR3A F158V and FCGR2A R131H polymorphisms and responsiveness to TNF blockers.
  
  
  
  The meta-analysis indicated that responsiveness to TNF blockers was associated with the FCGR3A V allele (odds ratio: 3.308; 95% CI: 1.053-10.39; p = 0.040) and the FCGR2A RR + RH genotype (odds ratio: 3.904; p = 0.027) in patients with a follow-up time of ≥6 months.
  
  
  
  FCGR3A V and FCGR2A R allele carriers show better responsiveness to anti-TNF-α therapy in patients with follow-up times ≥6 months.
authors.affiliation: Division of Rheumatology, Department of Internal Medicine, Korea University College of Medicine, Seoul, Korea.
authors.forename: Young Ho
authors.initials: YH
authors.lastname: Lee
authors.affiliation: Division of Rheumatology, Department of Internal Medicine, Korea University College of Medicine, Seoul, Korea.
authors.forename: Sung Jae
authors.initials: SJ
authors.lastname: Choi
authors.affiliation: Division of Rheumatology, Department of Internal Medicine, Korea University College of Medicine, Seoul, Korea.
authors.forename: Jong Dae
authors.initials: JD
authors.lastname: Ji
authors.affiliation: Division of Rheumatology, Department of Internal Medicine, Korea University College of Medicine, Seoul, Korea.
authors.forename: Gwan Gyu
authors.initials: GG
authors.lastname: Song
mesh_terms: D003424:Crohn Disease / Q000188:drug therapy* / Q000235:genetics*; D014644:Genetic Variation / Q000235:genetics; D006801:Humans; D011110:Polymorphism, Genetic / Q000235:genetics; D011565:Psoriasis / Q000188:drug therapy* / Q000235:genetics*; D017452:Receptors, IgG / Q000235:genetics*; D025242:Spondylarthropathies / Q000188:drug therapy* / Q000235:genetics*; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors*
chemical_list: C445323:FCGR2A protein, human; C496124:FCGR3A protein, human; D017452:Receptors, IgG; D014409:Tumor Necrosis Factor-alpha
keywords: FCGR polymorphism; TNF blockers; responsiveness; spondyloarthropathy