title: Probing inclusion complexes of cyclodextrins with amino acids by physicochemical approach.
abstract: Formations of host-guest inclusion complexes of two natural amino acids, viz., l-Leucine and l-Isoleucine as guests with α and β-cyclodextrins have been investigated which include diverse applications in modern science such as controlled delivery in the field of pharmaceuticals, food processing etc. Surface tension and conductivity studies establish the formation of inclusion complexes with 1:1 stoichiometry. The interactions of cyclodextrins with amino acids have been supported by density, viscosity, refractive index, hydration and solvation number measurements indicating higher degree of inclusion in case of α-cyclodextrin. l-Leucine interacts more with the hydrophobic cavity of cyclodextrin than its isomer. With the help of stability constant by NMR titration, hydrophobic effect, H-bonds and structural effects the formations of inclusion complexes have been explained.
authors.affiliation: Department of Chemistry, University of North Bengal, Darjeeling 734013, India. Electronic address: mahendraroy2002@yahoo.co.in.
authors.forename: Mahendra Nath
authors.initials: MN
authors.lastname: Roy
authors.affiliation: Department of Chemistry, University of North Bengal, Darjeeling 734013, India.
authors.forename: Aditi
authors.initials: A
authors.lastname: Roy
authors.affiliation: Department of Chemistry, University of North Bengal, Darjeeling 734013, India.
authors.forename: Subhadeep
authors.initials: S
authors.lastname: Saha
mesh_terms: D006863:Hydrogen-Ion Concentration; D007532:Isoleucine / Q000737:chemistry*; D007930:Leucine / Q000737:chemistry*; D066244:Proton Magnetic Resonance Spectroscopy; D013499:Surface Properties; D014783:Viscosity; D047391:alpha-Cyclodextrins / Q000737:chemistry*; D047392:beta-Cyclodextrins / Q000737:chemistry*
chemical_list: D047391:alpha-Cyclodextrins; D047392:beta-Cyclodextrins; D007532:Isoleucine; D007930:Leucine; C031215:betadex; C032613:alpha-cyclodextrin
keywords: Amino acid; Cyclodextrin; Inclusion complex; Physicochemical studies; Spectroscopic investigation; Thermodynamic parameter; l-Isoleucine (PubChem CID: 6306); l-Leucine (PubChem CID: 6106); α-Cyclodextrin (PubChem CID: 444913); β- (PubChem CID: 444041)