title: Sea Cucumber Saponin Echinoside A (EA) Stimulates Hepatic Fatty Acid β-Oxidation and Suppresses Fatty Acid Biosynthesis Coupling in a Diurnal Pattern.
abstract: Circadian rhythms control aspects of physiological events, including lipid metabolism, showing rhythmic fluctuation over 24 h. Therefore, it is not sufficient to evaluate thoroughly how dietary components regulate lipid metabolism with a single time-point assay. In the present study, a time-course study was performed to analyze the effect of sea cucumber saponin echinoside A (EA) on lipid metabolism over 24 h. Results showed that EA lowered the levels of TC and TG in both serum and liver at most time-points during the 24 h. Activities of hepatic lipogenic enzymes and lipolytic enzymes were inhibited and elevated respectively by EA to varied degrees at different time-points. Meanwhile, parallel variation trends of gene expression involved in fatty acid synthesis and β-oxidation were observed accordingly. The interaction between EA and lipid metabolism showed a time-dependent effect. Overall, EA impaired fatty acid synthesis and enhanced mitochondrial fatty acid β-oxidation in ad libitum feeding over 24 h.
authors.affiliation: College of Food Science and Engineering, Ocean University of China.
authors.forename: Min
authors.initials: M
authors.lastname: Wen
authors.forename: Xueyuan
authors.initials: X
authors.lastname: Fu
authors.forename: Xiuqing
authors.initials: X
authors.lastname: Han
authors.forename: Xiaoqian
authors.initials: X
authors.lastname: Hu
authors.forename: Ping
authors.initials: P
authors.lastname: Dong
authors.forename: Jie
authors.initials: J
authors.lastname: Xu
authors.forename: Yong
authors.initials: Y
authors.lastname: Xue
authors.forename: Jingfeng
authors.initials: J
authors.lastname: Wang
authors.forename: Changhu
authors.initials: C
authors.lastname: Xue
authors.forename: Yuming
authors.initials: Y
authors.lastname: Wang
mesh_terms: D000818:Animals; D002940:Circadian Rhythm; D005227:Fatty Acids / Q000096:biosynthesis / Q000378:metabolism*; D015870:Gene Expression / Q000187:drug effects; D006697:Holothurin / Q000031:analogs & derivatives* / Q000494:pharmacology; D050356:Lipid Metabolism / Q000187:drug effects*; D050155:Lipogenesis / Q000187:drug effects / Q000235:genetics; D008066:Lipolysis / Q000187:drug effects / Q000235:genetics; D008099:Liver / Q000187:drug effects / Q000201:enzymology*; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D010084:Oxidation-Reduction; D012616:Sea Cucumbers / Q000737:chemistry*
chemical_list: D005227:Fatty Acids; D006697:Holothurin; C043973:echinoside A