title: Why are we Still Dialyzing Overdoses to Tricyclic Antidepressants? A subanalysis of the NPDS database.
abstract: A recent analysis of the American Association of Poison Control Centers database, showed that poisonings from toxins not usually considered amenable to extracorporeal purification ("non-classic toxins" such as ethanol and tricyclic antidepressants) continue to be reported. This publication investigates factors that may explain these findings. Our results suggest that: 1) the relatively high absolute number of ECTR performed for non-classic toxins may simply reflect the large number of exposures to these toxins, 2) poisoning from another toxin may have been the reason for ECTR initiation in some exposures to non-classic toxins, 3) poisoning from non-classic toxins may receive ECTR for purposes other than toxin removal, and 4) the decisional threshold to initiate ECTR may be lower for non-classic toxins because of heightened toxicity.
authors.affiliation: Department of Medical Biology, Sacré-Coeur Hospital, University of Montreal, Montreal, Canada.
authors.forename: Valery
authors.initials: V
authors.lastname: Lavergne
authors.affiliation: Division of Medical Toxicology, Ronald O. Perelman Department of Emergency Medicine, New York University School of Medicine, New York.
authors.forename: Robert S
authors.initials: RS
authors.lastname: Hoffman
authors.affiliation: Indiana Poison Center, Indiana University Health, Indianapolis.
authors.forename: James B
authors.initials: JB
authors.lastname: Mowry
authors.affiliation: Department of Nephrology, Verdun Hospital, University of Montreal, Montreal, Canada.
authors.forename: Monique
authors.initials: M
authors.lastname: Cormier
authors.affiliation: Department of Medicine & Emergency Medicine, McGill University Health Centre, McGill University, Centre anti-poison du Quebec, Montreal, Canada.|Province of Alberta Drug Information Service, Calgary, Alberta.
authors.forename: Sophie
authors.initials: S
authors.lastname: Gosselin
authors.affiliation: Medical School, Australian National University and Renal Medicine, The Canberra Hospital, Canberra, Australia.
authors.forename: Darren M
authors.initials: DM
authors.lastname: Roberts
authors.affiliation: Department of Nephrology, Verdun Hospital, University of Montreal, Montreal, Canada. marcghannoum@gmail.com.
authors.forename: Marc
authors.initials: M
authors.lastname: Ghannoum
mesh_terms: D000929:Antidepressive Agents, Tricyclic / Q000506:poisoning*; D016208:Databases, Factual; D006464:Hemoperfusion; D006801:Humans; D011039:Poison Control Centers; D011041:Poisoning / Q000628:therapy*
chemical_list: D000929:Antidepressive Agents, Tricyclic