title: Total synthesis of teixobactin.
abstract: To cope with the global bacterial multidrug resistance, scientific communities have devoted significant efforts to develop novel antibiotics, particularly those with new modes of actions. Teixobactin, recently isolated from uncultured bacteria, is considered as a promising first-in-class drug candidate for clinical development. Herein, we report its total synthesis by a highly convergent Ser ligation approach and this strategy allows us to prepare several analogues of the natural product.
authors.affiliation: Department of Chemistry, State Key Lab of Synthetic Chemistry, The University of Hong Kong, Pokfulam Road, Hong Kong, China.
authors.forename: Kang
authors.initials: K
authors.lastname: Jin
authors.affiliation: Department of Chemistry, State Key Lab of Synthetic Chemistry, The University of Hong Kong, Pokfulam Road, Hong Kong, China.
authors.forename: Iek Hou
authors.initials: IH
authors.lastname: Sam
authors.affiliation: Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong, China.
authors.forename: Kathy Hiu Laam
authors.initials: KHL
authors.lastname: Po
authors.affiliation: Department of Chemistry, State Key Lab of Synthetic Chemistry, The University of Hong Kong, Pokfulam Road, Hong Kong, China.
authors.forename: Du'an
authors.initials: D
authors.lastname: Lin
authors.affiliation: Department of Chemistry, University of Central Florida, 4111 Libra Drive, Orlando, Florida 32816, USA.
authors.forename: Ebrahim H
authors.initials: EH
authors.lastname: Ghazvini Zadeh
authors.affiliation: Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong, China.
authors.forename: Sheng
authors.identifier: http://orcid.org/0000-0003-3526-7808
authors.initials: S
authors.lastname: Chen
authors.affiliation: Department of Chemistry, University of Central Florida, 4111 Libra Drive, Orlando, Florida 32816, USA.
authors.forename: Yu
authors.initials: Y
authors.lastname: Yuan
authors.affiliation: Department of Chemistry, State Key Lab of Synthetic Chemistry, The University of Hong Kong, Pokfulam Road, Hong Kong, China.
authors.forename: Xuechen
authors.initials: X
authors.lastname: Li