title: DPOAEs in infants developmentally exposed to PCBs show two differently time spaced exposure sensitive windows.
abstract: The study aim was to identify the timing of sensitive windows for ototoxicity related to perinatal exposure to PCBs. A total of 351 and 214 children from a birth cohort in eastern Slovakia underwent otoacoustic testing at 45 and 72 months, respectively, and distortion product otoacoustic emissions (DPOAEs) at 11 frequencies were recorded. Cord and child 6-, 16-, 45-, and 72- month blood samples were analyzed for PCB 153 concentration. The PCB 153 concentration-time profiles were approximated with a system model to calculate area under the PCB*time curves (AUCs) for specific time intervals (3 and 6 months for 45 and 72 months data, respectively). DPOAE amplitudes were correlated (Spearman) with cord serum PCB and AUCs, markers of prenatal and postnatal exposure, respectively. Two exposure critical windows were identified in infants, the first related to prenatal and early postnatal and the second to postnatal exposure to PCBs. Our data have shown tonotopicity, sexual dimorphism, and asymmetry in ototoxicity of PCBs.
authors.affiliation: Slovak Medical University, Limbová 14, 83303, Bratislava, Slovakia.
authors.forename: Vladimíra
authors.initials: V
authors.lastname: Koštiaková
authors.affiliation: University of Rome, Tor Vergata, Department of Physics, Rome, Italy.
authors.forename: Arturo
authors.initials: A
authors.lastname: Moleti
authors.affiliation: Slovak Medical University, Limbová 14, 83303, Bratislava, Slovakia.
authors.forename: Soňa
authors.initials: S
authors.lastname: Wimmerová
authors.affiliation: Departments of Public Health Sciences and Environmental Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA.
authors.forename: Todd A
authors.initials: TA
authors.lastname: Jusko
authors.affiliation: Slovak Medical University, Limbová 14, 83303, Bratislava, Slovakia.
authors.forename: Ľubica
authors.initials: Ľ
authors.lastname: Palkovičová Murínová
authors.affiliation: INAIL Research, Department of Occupational and Environmental Medicine, Epidemiology and Hygiene, Monteporzio Catone, Italy.
authors.forename: Renata
authors.initials: R
authors.lastname: Sisto
authors.affiliation: Slovak Medical University, Limbová 14, 83303, Bratislava, Slovakia.
authors.forename: Denisa
authors.initials: D
authors.lastname: Richterová
authors.affiliation: Department of Stomatology and Maxillofacial Surgery, Comenius University, Faculty of Medicine in Bratislava, Bratislava, Slovakia.
authors.forename: Ján
authors.initials: J
authors.lastname: Kováč
authors.affiliation: Slovak Medical University, Limbová 14, 83303, Bratislava, Slovakia.
authors.forename: Kamil
authors.initials: K
authors.lastname: Čonka
authors.affiliation: Slovak Medical University, Limbová 14, 83303, Bratislava, Slovakia.
authors.forename: Henrieta
authors.initials: H
authors.lastname: Patayová
authors.affiliation: Slovak Medical University, Limbová 14, 83303, Bratislava, Slovakia.
authors.forename: Juraj
authors.initials: J
authors.lastname: Tihányi
authors.affiliation: Slovak Medical University, Limbová 14, 83303, Bratislava, Slovakia. Electronic address: tomas.trnovec@szu.sk.
authors.forename: Tomáš
authors.initials: T
authors.lastname: Trnovec
mesh_terms: D001299:Audiometry; D002648:Child; D003051:Cochlea / Q000002:abnormalities / Q000187:drug effects / Q000503:physiopathology; D015331:Cohort Studies; D004781:Environmental Exposure / Q000009:adverse effects / Q000032:analysis*; D004785:Environmental Pollutants / Q000097:blood / Q000633:toxicity*; D005260:Female; D005312:Fetal Blood / Q000737:chemistry; D006801:Humans; D007223:Infant; D008297:Male; D010469:Perceptual Distortion / Q000187:drug effects*; D011078:Polychlorinated Biphenyls / Q000097:blood / Q000633:toxicity*; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000097:blood / Q000139:chemically induced* / Q000453:epidemiology; D018154:Slovakia
chemical_list: D004785:Environmental Pollutants; D011078:Polychlorinated Biphenyls; C014024:2,4,5,2',4',5'-hexachlorobiphenyl
keywords: Critical windows of exposure; Otoacoustic emissions; Ototoxicity; Polychlorinated biphenyls