title: Recent Advances of Using Hybrid Nanocarriers in Remotely Controlled Therapeutic Delivery.
abstract: The development of hybrid biomaterials has been attracting great attention in the design of materials for biomedicine. The nanosized level of inorganic and organic or even bioactive components can be combined into a single material by this approach, which has created entirely new advanced compositions with truly unique properties for drug delivery. The recent advances in using hybrid nanovehicles as remotely controlled therapeutic delivery carriers are summarized with respect to different nanostructures, including hybrid host-guest nanoconjugates, micelles, nanogels, core-shell nanoparticles, liposomes, mesoporous silica, and hollow nanoconstructions. In addition, the controlled release of guest molecules from these hybrid nanovehicles in response to various remote stimuli such as alternating magnetic field, near infrared, or ultrasound triggers is further summarized to introduce the different mechanisms of remotely triggered release behavior. Through proper chemical functionalization, the hybrid nanovehicle system can be further endowed with many new properties toward specific biomedical applications.
authors.affiliation: Institute of Materials Research and Engineering (IMRE), A*STAR, 2 Fusionopolis Way. Innovis, #08-03, Singapore, 138634, Singapore.
authors.forename: Zibiao
authors.initials: Z
authors.lastname: Li
authors.affiliation: Institute of Materials Research and Engineering (IMRE), A*STAR, 2 Fusionopolis Way. Innovis, #08-03, Singapore, 138634, Singapore.
authors.forename: Enyi
authors.initials: E
authors.lastname: Ye
authors.affiliation: Department of Materials Science and Engineering, National University of Singapore, 9 Engineering Drive 1, Singapore, 117576, Singapore.
authors.lastname: David
authors.affiliation: Singapore Eye Research Institute, 11 Third Hospital Avenue, Singapore, 168751, Singapore.
authors.forename: Rajamani
authors.initials: R
authors.lastname: Lakshminarayanan
authors.affiliation: Institute of Materials Research and Engineering (IMRE), A*STAR, 2 Fusionopolis Way. Innovis, #08-03, Singapore, 138634, Singapore. lohxj@imre.a-star.edu.sg.|Department of Materials Science and Engineering, National University of Singapore, 9 Engineering Drive 1, Singapore, 117576, Singapore. lohxj@imre.a-star.edu.sg.|Singapore Eye Research Institute, 11 Third Hospital Avenue, Singapore, 168751, Singapore. lohxj@imre.a-star.edu.sg.
authors.forename: Xian Jun
authors.initials: XJ
authors.lastname: Loh
mesh_terms: D004337:Drug Carriers / Q000737:chemistry*; D016503:Drug Delivery Systems / Q000379:methods*; D065546:Drug Liberation; D008081:Liposomes / Q000737:chemistry; D060526:Magnetic Fields; D053758:Nanoparticles / Q000737:chemistry*
chemical_list: D004337:Drug Carriers; D008081:Liposomes
keywords: NIR; drug delivery; nanoparticles; remote; ultrasound