title: HPLC profiling of antimicrobial and antioxidant phyco sugars isolated from the South West coast of India.
abstract: Phyco sugars isolated from the South West coast of India are commercially and therapeutically interesting due to their various biological activities. These sugars were isolated from six (three red and three green) seaweed species using water at 100°C followed by precipitation using ethanol. The physical, chemical and biological characteristics were explored with specific highlights onto the specific rotation, HPLC-RI sugar speciation, antioxidant and antimicrobial activities. The biological properties were evaluated based on multiple methods and standards, such that the actual nature of the sugar is understood. G. corticata var. cylindrica (31.66%) had the highest sugar content. All the sugars had levo rotatory specific rotation and interesting chemical characteristics. Sugars isolated had competitive biological activities and had the presence of seven monosaccharides and one disaccharide. The results highlighted the socio-economic importance of seaweeds which could be developed as a potential source of bioactive compounds in the upcoming future.
authors.affiliation: Department of Chemical Oceanography, School of Marine Sciences, Cochin University of Science and Technology (CUSAT), Cochin 682016, India. Electronic address: abhilashpkailas@gmail.com.
authors.forename: Abhilash Parameswaran
authors.initials: AP
authors.lastname: Kailas
authors.affiliation: Department of Chemical Oceanography, School of Marine Sciences, Cochin University of Science and Technology (CUSAT), Cochin 682016, India.
authors.forename: Sukumaran Muraleedharan
authors.initials: SM
authors.lastname: Nair
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D000975:Antioxidants / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D002851:Chromatography, High Pressure Liquid; D007194:India; D012624:Seaweed / Q000737:chemistry; D000073893:Sugars / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D013431:Sulfates / Q000032:analysis
chemical_list: D000900:Anti-Bacterial Agents; D000975:Antioxidants; D000073893:Sugars; D013431:Sulfates
keywords: Bioactivity; HPLC; Phyco sugars; Specific rotation; Sulfate