title: Intratubular large cell hyalinizing Sertoli cell tumor of the testis presenting with prepubertal gynecomastia: a case report.
abstract: Intratubular large cell hyalinizing Sertoli cell neoplasia (ITLCHSCN) resulting from Sertoli cells of the testis are mainly reported in young adults and these are rarely seen in childhood. The most common presenting symptoms of the patients diagnosed with ITLCHSCN are gynecomastia, enlargement in the testicles, increase in growth velocity, and advanced bone age. Symptoms are basically resulting from increased aromatase enzyme activity in Sertoli cells. In this case report, an eight-and-a-half-year-old case presenting with complaint of bilateral gynecomastia since two years, showing no endocrine abnormality in laboratory during two years of follow-up, determined to have progression in bilateral gynecomastia, increase in testicular volumes, advanced bone age, increase in growth velocity in the clinical follow-up, and diagnosed with ITLCHSCN after testis biopsy was presented.
authors.affiliation: a Faculty of Medicine, Department of Pediatric Endocrinology , Dokuz Eylul University , Izmir , Turkey.
authors.forename: Hale
authors.initials: H
authors.lastname: Tuhan
authors.affiliation: a Faculty of Medicine, Department of Pediatric Endocrinology , Dokuz Eylul University , Izmir , Turkey.
authors.forename: Ayhan
authors.initials: A
authors.lastname: Abaci
authors.affiliation: b Faculty of Medicine, Department of Pathology , Ege University , Izmir , Turkey.
authors.forename: Banu
authors.initials: B
authors.lastname: Sarsık
authors.affiliation: c Faculty of Medicine, Department of Pediatric Radiology , Dokuz Eylul University , Izmir , Turkey.
authors.forename: Tülay
authors.initials: T
authors.lastname: Öztürk
authors.affiliation: d Faculty of Medicine, Department of Pediatric Surgery , Dokuz Eylul University , İzmir , Turkey.
authors.forename: Mustafa
authors.initials: M
authors.lastname: Olguner
authors.affiliation: a Faculty of Medicine, Department of Pediatric Endocrinology , Dokuz Eylul University , Izmir , Turkey.
authors.forename: Gonul
authors.initials: G
authors.lastname: Catli
authors.affiliation: a Faculty of Medicine, Department of Pediatric Endocrinology , Dokuz Eylul University , Izmir , Turkey.
authors.forename: Ahmet
authors.initials: A
authors.lastname: Anik
authors.affiliation: e Faculty of Medicine, Department of Pediatric Oncology , Dokuz Eylul University , Izmir , Turkey.
authors.forename: Nur
authors.initials: N
authors.lastname: Olgun
authors.affiliation: a Faculty of Medicine, Department of Pediatric Endocrinology , Dokuz Eylul University , Izmir , Turkey.
authors.forename: Ece
authors.initials: E
authors.lastname: Bober
mesh_terms: D002648:Child; D006177:Gynecomastia / Q000209:etiology*; D006801:Humans; D008297:Male; D012707:Sertoli Cell Tumor / Q000150:complications* / Q000175:diagnosis* / Q000628:therapy; D013736:Testicular Neoplasms / Q000150:complications* / Q000175:diagnosis* / Q000628:therapy
keywords: Prepubertal gynecomastia; Sertoli cell tumor; Testicular microlithiasis