title: The double-edged role of 12/15-lipoxygenase during inflammation and immunity.
abstract: 12/15-Lipoxygenase (12/15-LOX) mediates the enzymatic oxidation of polyunsaturated fatty acids, thereby contributing to the generation of various bioactive lipid mediators. Although 12/15-LOX has been implicated in the pathogenesis of multiple chronic inflammatory diseases, its physiologic functions seem to include potent immune modulatory properties that physiologically contribute to the resolution of inflammation and the clearance of inflammation-associated tissue damage. This review aims to give a comprehensive overview about our current knowledge on the role of this enzyme during the regulation of inflammation and immunity. This article is part of a Special Issue entitled: Lipid modification and lipid peroxidation products in innate immunity and inflammation edited by Christoph J. Binder.
authors.affiliation: Department of Internal Medicine 3 and Institute for Clinical Immunology, University Hospital Erlangen, Erlangen, Germany; Nikolaus Fiebiger Center of Molecular Medicine, University Hospital Erlangen, University of Erlangen-Nuremberg, Erlangen, Germany.
authors.forename: Jochen A
authors.initials: JA
authors.lastname: Ackermann
authors.affiliation: Department of Internal Medicine 3 and Institute for Clinical Immunology, University Hospital Erlangen, Erlangen, Germany; Nikolaus Fiebiger Center of Molecular Medicine, University Hospital Erlangen, University of Erlangen-Nuremberg, Erlangen, Germany.
authors.forename: Katharina
authors.initials: K
authors.lastname: Hofheinz
authors.affiliation: Department of Internal Medicine 3 and Institute for Clinical Immunology, University Hospital Erlangen, Erlangen, Germany.
authors.forename: Mario M
authors.initials: MM
authors.lastname: Zaiss
authors.affiliation: Department of Internal Medicine 3 and Institute for Clinical Immunology, University Hospital Erlangen, Erlangen, Germany; Nikolaus Fiebiger Center of Molecular Medicine, University Hospital Erlangen, University of Erlangen-Nuremberg, Erlangen, Germany. Electronic address: gerhard.kroenke@uk-erlangen.de.
authors.forename: Gerhard
authors.initials: G
authors.lastname: Krönke
mesh_terms: D000818:Animals; D001092:Arachidonate 12-Lipoxygenase / Q000276:immunology* / Q000378:metabolism*; D001093:Arachidonate 15-Lipoxygenase / Q000276:immunology* / Q000378:metabolism*; D006801:Humans; D007109:Immunity / Q000276:immunology*; D007249:Inflammation / Q000276:immunology / Q000378:metabolism*; D015227:Lipid Peroxidation / Q000276:immunology / Q000502:physiology
chemical_list: D001092:Arachidonate 12-Lipoxygenase; D001093:Arachidonate 15-Lipoxygenase
keywords: Inflammation; Lipid oxidation; Lipoxins; Lipoxygenase; Macrophages; Resolution