title: Gold-Catalyzed Domino Synthesis of Functionalized Benzofurans and Tetracyclic Isochromans via Formal Carboalkoxylation.
abstract: A domino synthesis of benzofurans with the modification of side chains from α-alkoxyalkyl o-alkynylaryl ethers (n = 0) and electron-rich arenes has been developed. In the present domino reaction, which would proceed via the α-alkoxyalkylation of arenes with an intermediate in the migratory cycloisomerization of o-alkynylaryl ethers followed by the nucleophilic addition of benzofurans to benzyl ethers, a cationic Au(III) catalyst activates the C-C π bond and the C-O σ bond. The present method could be extended to Au(I)-catalyzed domino synthesis of tetracyclic isochromans from α-alkoxyalkyl (o-alkynylaryl)methyl ethers (n = 1) and aryl methoxymethyl ethers.
authors.affiliation: Division of Applied Chemistry, Institute of Engineering and ‡Instrumentation Analysis Center, Tokyo University of Agriculture and Technology , 2-24-16 Naka-cho, Koganei, Tokyo 184-8588, Japan.
authors.forename: Tomoyuki
authors.initials: T
authors.lastname: Obata
authors.affiliation: Division of Applied Chemistry, Institute of Engineering and ‡Instrumentation Analysis Center, Tokyo University of Agriculture and Technology , 2-24-16 Naka-cho, Koganei, Tokyo 184-8588, Japan.
authors.forename: Sho
authors.initials: S
authors.lastname: Suzuki
authors.affiliation: Division of Applied Chemistry, Institute of Engineering and ‡Instrumentation Analysis Center, Tokyo University of Agriculture and Technology , 2-24-16 Naka-cho, Koganei, Tokyo 184-8588, Japan.
authors.forename: Asuka
authors.initials: A
authors.lastname: Nakagawa
authors.affiliation: Division of Applied Chemistry, Institute of Engineering and ‡Instrumentation Analysis Center, Tokyo University of Agriculture and Technology , 2-24-16 Naka-cho, Koganei, Tokyo 184-8588, Japan.
authors.forename: Ryota
authors.initials: R
authors.lastname: Kajihara
authors.affiliation: Division of Applied Chemistry, Institute of Engineering and ‡Instrumentation Analysis Center, Tokyo University of Agriculture and Technology , 2-24-16 Naka-cho, Koganei, Tokyo 184-8588, Japan.
authors.forename: Keiichi
authors.initials: K
authors.lastname: Noguchi
authors.affiliation: Division of Applied Chemistry, Institute of Engineering and ‡Instrumentation Analysis Center, Tokyo University of Agriculture and Technology , 2-24-16 Naka-cho, Koganei, Tokyo 184-8588, Japan.
authors.forename: Akio
authors.initials: A
authors.lastname: Saito