title: Multiple epithelioid hemangioedothelioma of the skull in a child: A case report.
abstract: BACKGROUND
  Epithelioid hemangioedothelioma (EHE) is a rare vascular tumor characterized by neoplastic proliferation of epithelioid or histiocytoid epithelial cells. EHE of bone constitutes <1% of primary malignant bone tumor. EHE in the skull is an extremely rare case. Here, we report a case of multiple neoplasm of the skull in a 15-month-old boy who presented with gradual facial swelling for 2 months. On computed tomography (CT) scan, multiple irregular osteolytic lesions were seen on the right maxillary, sphenoid, left zygoma, and roof of the left orbit. Excisional surgery of the lesion was planned. Histopathological and immunohistochemical examination of excised specimen suggest it to be epithelioid hemangioedothelioma. Follow-up for 6 months showed no recurrence.
  
  
  CONCLUSIONS
  Epithelioid hemangioedothelioma is a locally aggressive tumor with metastatic potential. CT imaging could help in assessment of lesion, but final diagnosis is possible only with histopathology. Complete surgical resection at the early stage of the disease is the most effective treatment with better prognosis.
authors.affiliation: Department of Radiology Department of Medical Records Management, the First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Zhu
authors.forename: Miao
authors.initials: M
authors.lastname: Fan
authors.forename: Sagar
authors.initials: S
authors.lastname: Pandey
authors.forename: Wei
authors.initials: W
authors.lastname: Liang
authors.forename: Dandan
authors.initials: D
authors.lastname: Chang
mesh_terms: D018323:Hemangioendothelioma, Epithelioid / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery; D006801:Humans; D007223:Infant; D008297:Male; D009378:Neoplasms, Multiple Primary / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery; D012888:Skull Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery