title: The influence of body composition on renal function in patients with coronary artery disease and its prognostic significance: a retrospective cohort study.
abstract: We try to analyse the effect of renal functions on death in CAD patients with different body compositions.
  
  
  
  A retrospective analysis was conducted in 2989 consecutive patients with CAD confirmed by coronary angiography were enrolled and were grouped into two categories: basically preserved renal function (PRF) (eGFR ≥60 ml/min) and obviously reduced renal function (RRF) (eGFR <60 ml/min). The influence of renal insufficiency on mortality of CAD was detected in every tertile of body composition, including body mass index (BMI), body fat (BF) and lean mass index (LMI). The end points were all-cause mortality.
  
  
  
  The mean follow-up time was 29.1 ± 12.5 months and death events occurred in 271 cases. The percentage of patients with RRF was positively correlated with BF and inversely correlated with the LMI, but no relationship to BMI. The survival curves showed that the risk of death was significantly higher in the RRF patients in all subgroups stratified using BMI, BF, or LMI (log rank test, all p < 0.001). The COX multivariate regression analysis showed that the risk of death was significantly higher in the RRF patients with high BF (HR 1.95, CI 1.25-3.05) and low LMI (HR 1.82, CI 1.19-2.79). Meanwhile, risk of death was significantly higher in RRF patients with a high BMI (HR 2.08, CI 1.22-3.55) or low BMI (HR 1.98, CI 1.28-3.08) but this risk was not significant in patients with a medium BMI (HR 1.12, 0.65-1.94). The subgroup analysis of patients with acute coronary syndrome (ACS) showed similar results.
  
  
  
  For patients with CAD, renal insufficiency was positively correlated with BF, inversely correlated with LMI, and unrelated to BMI. The effect of renal insufficiency on the risk of death of CAD was related to body composition.
authors.affiliation: Department of Cardiology, West China Hospital, Sichuan University, 37 Guoxue Street, 610041, Chengdu, People's Republic of China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Peng
authors.affiliation: Department of Cardiology, West China Hospital, Sichuan University, 37 Guoxue Street, 610041, Chengdu, People's Republic of China.
authors.forename: Hua
authors.initials: H
authors.lastname: Wang
authors.affiliation: Department of Cardiology, West China Hospital, Sichuan University, 37 Guoxue Street, 610041, Chengdu, People's Republic of China.
authors.forename: Fei
authors.initials: F
authors.lastname: Chen
authors.affiliation: Department of Cardiology, West China Hospital, Sichuan University, 37 Guoxue Street, 610041, Chengdu, People's Republic of China.
authors.forename: Fang-Yang
authors.initials: FY
authors.lastname: Huang
authors.affiliation: Department of Cardiology, West China Hospital, Sichuan University, 37 Guoxue Street, 610041, Chengdu, People's Republic of China.
authors.forename: Tian-Li
authors.initials: TL
authors.lastname: Xia
authors.affiliation: Department of Cardiology, West China Hospital, Sichuan University, 37 Guoxue Street, 610041, Chengdu, People's Republic of China.
authors.forename: Yan-Biao
authors.initials: YB
authors.lastname: Liao
authors.affiliation: Department of Cardiology, West China Hospital, Sichuan University, 37 Guoxue Street, 610041, Chengdu, People's Republic of China.
authors.forename: Hua
authors.initials: H
authors.lastname: Chai
authors.affiliation: Department of Cardiology, West China Hospital, Sichuan University, 37 Guoxue Street, 610041, Chengdu, People's Republic of China.
authors.forename: Peng-Ju
authors.initials: PJ
authors.lastname: Wang
authors.affiliation: Department of Cardiology, West China Hospital, Sichuan University, 37 Guoxue Street, 610041, Chengdu, People's Republic of China.
authors.forename: Zhi-Liang
authors.initials: ZL
authors.lastname: Zuo
authors.affiliation: Department of Cardiology, West China Hospital, Sichuan University, 37 Guoxue Street, 610041, Chengdu, People's Republic of China.
authors.forename: Wei
authors.initials: W
authors.lastname: Liu
authors.affiliation: Department of Cardiology, West China Hospital, Sichuan University, 37 Guoxue Street, 610041, Chengdu, People's Republic of China.
authors.forename: Chen
authors.initials: C
authors.lastname: Zhang
authors.affiliation: Department of Cardiology, West China Hospital, Sichuan University, 37 Guoxue Street, 610041, Chengdu, People's Republic of China.
authors.forename: Yi-Jian
authors.initials: YJ
authors.lastname: Li
authors.affiliation: Department of Cardiology, West China Hospital, Sichuan University, 37 Guoxue Street, 610041, Chengdu, People's Republic of China.
authors.forename: Yi-Yue
authors.initials: YY
authors.lastname: Gui
authors.affiliation: Department of Cardiology, West China Hospital, Sichuan University, 37 Guoxue Street, 610041, Chengdu, People's Republic of China. hmaochen@vip.sina.com.
authors.forename: Mao
authors.initials: M
authors.lastname: Chen
authors.affiliation: Department of Cardiology, West China Hospital, Sichuan University, 37 Guoxue Street, 610041, Chengdu, People's Republic of China. huangdjmd@163.com.
authors.forename: De-Jia
authors.initials: DJ
authors.lastname: Huang
mesh_terms: D000328:Adult; D000368:Aged; D001823:Body Composition / Q000502:physiology*; D015992:Body Mass Index; D015331:Cohort Studies; D003324:Coronary Artery Disease / Q000150:complications* / Q000175:diagnosis*; D005260:Female; D006801:Humans; D007668:Kidney / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000150:complications* / Q000175:diagnosis; D011379:Prognosis; D012189:Retrospective Studies
keywords: Body composition; Coronary artery disease; Prognosis; Renal function