title: Significance of positive selection and gene duplication in adaptive evolution: in memory of Austin L. Hughes.
abstract: In this minireview, we highlight the contributions of the late Austin L. Hughes to two areas of molecular evolution: the role of positive (Darwinian) selection, and the impact of gene duplications during genome evolution.
authors.affiliation: UCD Conway Institute and School of Medicine, University College Dublin, Dublin 4, Ireland. kenneth.wolfe@ucd.ie.
authors.forename: Ken
authors.initials: K
authors.lastname: Wolfe
authors.affiliation: Cancer Inflammation Program, Laboratory of Experimental Immunology, Leidos-Frederick, Incorporated, Frederick National Laboratory for Cancer Research, Frederick, MD, 21702, USA.
authors.forename: Colm
authors.initials: C
authors.lastname: Ó'hUigín
mesh_terms: D000222:Adaptation, Physiological / Q000235:genetics*; D000818:Animals; D005075:Biological Evolution; D020440:Gene Duplication; D016678:Genome; D006801:Humans; D012641:Selection, Genetic / Q000235:genetics*
keywords: Duplication; Evolution; Selection