title: Clinicopathological Characteristics, Treatment, and Prognosis of 21 Patients with Primary Gastric Squamous Cell Carcinoma.
abstract: We performed a retrospective analysis of 21 patients with primary gastric squamous cell carcinoma (PGSCC) who were admitted to our hospital from October 2008 to October 2014. The median age was 67 years and male predominance was observed, the most common tumor locations were the upper third of the stomach, most of the clinical manifestations were identical to those of other types of gastric tumors, and the tumor cells had positive immunoreactivity for p63 and CK5/6. In terms of treatments, surgery (R0 resection) is the main treatment; the effect of other treatments is unclear. The median survival time for the surgery group and nonsurgery group was 46 and 4.5 months, respectively. Probably due to limited number of cases, no significant difference in median survival time was observed between the surgery alone group and the surgery plus adjuvant therapy group (46 versus 51 months, P = 0.310). A standard chemotherapy regimen for this disease has not yet been established; the choice of its chemotherapy regimens tends to follow the principle of the treatment of gastric adenocarcinoma or esophageal cancer. PGSCC generally had a poor prognosis, and early detection, early diagnosis, and early surgical treatment are beneficial to patients.
authors.affiliation: Cancer Center, West China Hospital, Sichuan University, 37 Guoxue Alley, Chengdu, Sichuan 610041, China.
authors.forename: Yang
authors.identifier: 0000-0002-2830-3914
authors.initials: Y
authors.lastname: Chen
authors.affiliation: Cancer Center, West China Hospital, Sichuan University, 37 Guoxue Alley, Chengdu, Sichuan 610041, China.
authors.forename: Hong
authors.identifier: 0000-0002-2087-3306
authors.initials: H
authors.lastname: Zhu
authors.affiliation: Cancer Center, West China Hospital, Sichuan University, 37 Guoxue Alley, Chengdu, Sichuan 610041, China.
authors.forename: Feng
authors.initials: F
authors.lastname: Xu
authors.affiliation: Cancer Center, West China Hospital, Sichuan University, 37 Guoxue Alley, Chengdu, Sichuan 610041, China.
authors.forename: Yidan
authors.initials: Y
authors.lastname: Cao
authors.affiliation: Cancer Center, West China Hospital, Sichuan University, 37 Guoxue Alley, Chengdu, Sichuan 610041, China.
authors.forename: Xingting
authors.initials: X
authors.lastname: Gu
authors.affiliation: Cancer Center, West China Hospital, Sichuan University, 37 Guoxue Alley, Chengdu, Sichuan 610041, China.
authors.forename: Yuming
authors.initials: Y
authors.lastname: Wan
authors.affiliation: Cancer Center, West China Hospital, Sichuan University, 37 Guoxue Alley, Chengdu, Sichuan 610041, China.
authors.forename: Hongfeng
authors.identifier: 0000-0002-8610-1341
authors.initials: H
authors.lastname: Gou