title: Pd(II)-Catalyzed Intramolecular Tandem Olefin Amidation/C-H Activation Protocol for the Syntheses of the Protoberberine Class of Natural Products.
abstract: A Pd(II)-catalyzed intramolecular tandem olefin amidation/C-H activation protocol has been developed for the synthesis of an 8-oxoprotoberberine core. It was successfully applied for the syntheses of (±)-8-oxocanadine, (±)-8-oxotetrahydropalmitine, and (±)-8-oxostylopine, which can be easily converted to the respective protoberberine natural products. The short synthetic route demonstrated would be useful for the synthesis of a large number of natural products and their analogues featuring a protoberberine scaffold.
authors.affiliation: Division of Organic Chemistry, CSIR-National Chemical Laboratory , Pune 411 008, India.
authors.forename: Dnyaneshwar N
authors.initials: DN
authors.lastname: Garad
authors.affiliation: Division of Organic Chemistry, CSIR-National Chemical Laboratory , Pune 411 008, India.
authors.forename: Santosh B
authors.initials: SB
authors.lastname: Mhaske