title: Analysis of pre- and post-pregnancy issues in women with hyperemesis gravidarum.
abstract: The purpose of this study is to determine the frequency of reporting of both pre-pregnancy and post-pregnancy psychosocial and physical issues in women with hyperemesis gravidarum (HG). Conditions in 449 women with HG were compared to 459 unaffected women (controls). Binary responses were analyzed using either Chi-squared or Fishers Exact test. Continuous responses were analyzed using a t-test. Among 60 pre-pregnancy conditions surveyed, 10 common (>5%) maternal pre-pregnancy conditions were significantly more frequently reported by women with HG. Twenty rare (<5% controls) pre-pregnancy conditions with significantly increased reporting in the HG group were identified. Thirty (50%) pre-pregnancy conditions were similarly reported between cases and controls. Among 80 post-pregnancy factors surveyed, women with HG also showed significantly higher reporting for 7 common and 50 rare post-pregnancy outcomes. Women with HG are significantly more likely to self-report physical and psychosocial issues both before and after pregnancy.
authors.affiliation: Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA, United States.
authors.forename: Rayna
authors.initials: R
authors.lastname: Tian
authors.affiliation: Hyperemesis Education and Research Foundation, Damascus, OR, United States.
authors.forename: Kimber
authors.initials: K
authors.lastname: MacGibbon
authors.affiliation: Department of Obstetrics and Gynecology, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States.
authors.forename: Bhuvan
authors.initials: B
authors.lastname: Martin
authors.affiliation: Department of Obstetrics and Gynecology, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States.
authors.forename: Patrick
authors.initials: P
authors.lastname: Mullin
authors.affiliation: Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA, United States; Department of Obstetrics and Gynecology, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States. Electronic address: mfejzo@mednet.ucla.edu.
authors.forename: Marlena
authors.initials: M
authors.lastname: Fejzo
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D006939:Hyperemesis Gravidarum / Q000150:complications* / Q000453:epidemiology*; D020407:Internet; D008875:Middle Aged; D011247:Pregnancy; D057566:Self Report; D011795:Surveys and Questionnaires; D013997:Time Factors; D055815:Young Adult
keywords: Hyperemesis gravidarum; Nausea; Pregnancy; Psychosocial