title: Primary intraspinal dumbbell-shaped mesenchymal chondrosarcoma with massive calcifications: a case report and review of the literature.
abstract: BACKGROUND
  Mesenchymal chondrosarcoma is a rare malignant tumor arising from bone or soft tissues. Instraspinal dumbbell-shaped mesenchymal chondrosarcoma is even rarer; however, it should not be neglected by clinicians.
  
  
  METHODS
  A 26-year-old female was referred to our hospital with a 1.5-month history of sciatic pain and numbness in the left leg. Computed tomography and magnetic resonance imaging scans revealed an intraspinal dumbbell-shaped mass which had distinguishing features of neurogenic tumors, surprisingly, with massive calcifications, and no tumor metastasis was found. Then the patient underwent a total resection of the tumor, and during the operation, we found that the right nerve root of the fifth lumbar almost disappeared. The tumor was diagnosed as mesenchymal chondrosarcoma by histopathological examination after operation. Adjuvant therapies were not performed. However, recurrence of the tumor occurred 5 months later, and she underwent a total resection again combined with radiotherapy after second surgery.
  
  
  CONCLUSIONS
  To the best of our knowledge, this case study presents the first report in literature about primary instraspinal dumbbell-shaped mesenchymal chondrosarcoma with massive calcifications, which may provide some evidence for clinical practice. As the clinical symptoms and radiographic findings of mesenchymal chondrosarcoma are usually not specific, clinicians should consider it as a possible case and diagnose it through careful histopathological examination. Sometimes, calcification could be seen in tumors, which may influence or reflect the growth of tumor and disease prognosis. Although prognosis in mesenchymal chondrosarcoma varies from person to person, generally, complete resection, adjuvant therapy, and regular examinations are recommended to perform for patients with mesenchymal chondrosarcoma.
authors.affiliation: Guangdong Provincial Hospital of Chinese Medicine, No. 111 Dade Road, Yuexiu District, Guangzhou, 510120, China.|Guangzhou University of Chinese Medicine, Guangzhou, China.|Guangdong Provincial Academy of Chinese Medical Sciences, Guangzhou, China.
authors.forename: Shudong
authors.initials: S
authors.lastname: Chen
authors.affiliation: Guangdong Provincial Hospital of Chinese Medicine, No. 111 Dade Road, Yuexiu District, Guangzhou, 510120, China.|Guangdong Provincial Academy of Chinese Medical Sciences, Guangzhou, China.
authors.forename: Yufeng
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Guangdong Provincial Hospital of Chinese Medicine, No. 111 Dade Road, Yuexiu District, Guangzhou, 510120, China.|Guangdong Provincial Academy of Chinese Medical Sciences, Guangzhou, China.
authors.forename: Guoyi
authors.initials: G
authors.lastname: Su
authors.affiliation: Guangdong Provincial Hospital of Chinese Medicine, No. 111 Dade Road, Yuexiu District, Guangzhou, 510120, China.|Guangzhou University of Chinese Medicine, Guangzhou, China.|Guangdong Provincial Academy of Chinese Medical Sciences, Guangzhou, China.
authors.forename: Bolai
authors.initials: B
authors.lastname: Chen
authors.affiliation: Guangdong Provincial Hospital of Chinese Medicine, No. 111 Dade Road, Yuexiu District, Guangzhou, 510120, China. lindingkun_tcm@163.com.|Guangzhou University of Chinese Medicine, Guangzhou, China. lindingkun_tcm@163.com.|Guangdong Provincial Academy of Chinese Medical Sciences, Guangzhou, China. lindingkun_tcm@163.com.
authors.forename: Dingkun
authors.initials: D
authors.lastname: Lin
mesh_terms: D000328:Adult; D014408:Biomarkers, Tumor / Q000378:metabolism; D001706:Biopsy; D001932:Brain Neoplasms / Q000188:drug therapy / Q000532:radiotherapy / Q000556:secondary; D002114:Calcinosis / Q000000981:diagnostic imaging / Q000601:surgery*; D002648:Child; D002675:Child, Preschool; D018211:Chondrosarcoma, Mesenchymal / Q000150:complications / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery*; D005260:Female; D006801:Humans; D008159:Lumbar Vertebrae / Q000000981:diagnostic imaging / Q000601:surgery*; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000532:radiotherapy / Q000601:surgery; D011379:Prognosis; D018714:Radiotherapy, Adjuvant; D035583:Rare Diseases / Q000150:complications / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery*; D012585:Sciatica / Q000209:etiology; D013125:Spinal Neoplasms / Q000150:complications / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery*; D014057:Tomography, X-Ray Computed
chemical_list: D014408:Biomarkers, Tumor
keywords: Calcification; Intraspinal; Mesenchymal chondrosarcoma; Spinal tumor; Surgery