title: Dynamics of Concomitant Functional Mitral Regurgitation in Patients with Aortic Stenosis Undergoing TAVI.
abstract: BACKGROUND
  The aim of this study was to investigate the echocardiographic features of functional mitral regurgitation (MR) in patients with aortic stenosis (AS) pre- and post-trans catheter aortic valve implantation (TAVI).
  
  
  METHODS
  The study subjects consisted of 79 patients with severe AS, who underwent TAVI. The echocardiographic parameters related to MR severity prior to TAVI and the change in these parameters and MR severity within one month after implantation were retrospectively evaluated.
  
  
  RESULTS
  The mean left ventricular ejection fraction (LVEF) was 53 ± 12%, and the mean MR severity was 1.2 ± 0.7. Among the baseline parameters, age (p = 0.019, r = 0.264), LV mass (p = 0.017, r = 0.269), deceleration time (DT) (p = 0.019, r = -0.266), left atrial diameter (p = 0.003, r = 0.325), were related to pre-procedure MR severity. After TAVI, the grade of MR (1.2 ± 0.7 vs. 0.8 ± 0.6, p < 0.001) and MR duration (43 ± 19% vs. 31 ± 23%, p < 0.001) were significantly decreased. The grade of pre-procedural MR (p < 0.001) was a predictor of residual MR after TAVI. However, there was not a significant change in the left ventricular echocardiographic parameters after TAVI [LVEF (53 ± 12 vs. 52 ± 11, p = 0.285), and LV mass (302 ± 84 vs. 306 ± 76 g, p = 0.495)].
  
  
  CONCLUSIONS
  In patients with severe AS, functional MR is related to age, LV mass, DT and left atrial diameter. TAVI improves MR in these patients, even before LV remodelling occurs.
authors.affiliation: Department of Cardiology; ; Gazi University, School of Medicine, Department of Cardiology, Ankara, Turkey.
authors.forename: Asife
authors.initials: A
authors.lastname: Sahinarslan
authors.affiliation: Department of Cardiology;
authors.forename: Francesco
authors.initials: F
authors.lastname: Vecchio
authors.affiliation: Department of Cardiology;
authors.forename: Philip
authors.initials: P
authors.lastname: MacCarthy
authors.affiliation: Department of Cardiology;
authors.forename: Rafal
authors.initials: R
authors.lastname: Dworakowski
authors.affiliation: Department of Cardiovascular Surgery, King's College Hospital, London, UK;
authors.forename: Ranjit
authors.initials: R
authors.lastname: Deshpande
authors.affiliation: Department of Cardiovascular Surgery, King's College Hospital, London, UK;
authors.forename: Olaf
authors.initials: O
authors.lastname: Wendler
authors.affiliation: Department of Cardiology;
authors.forename: Mark
authors.initials: M
authors.lastname: Monaghan
keywords: Aortic stenosis; Mitral regurgitation; Trans catheter aortic valve implantation (TAVI)