title: Complex Assembly of Polymer Conjugated Mesoporous Silica Nanoparticles for Intracellular pH-Responsive Drug Delivery.
abstract: There is a great challenge in constructing pH-responsive drug delivery systems in biomedical application research. Many nanocomposites are intended to be pH-responsive as drug carriers because of a tumorous or intracellular mildly acidic environment. However, it is always difficult to find an appropriate system for quick response and release before the carrier is excreted from the living system. In this work, hyperbranched polymer, hyperbranched polyglycerol (hPG), and conjugated mesoporous silica nanoparticles (MSNs) were assembled as complexes to serve as drug carriers. Herein, the conjugated polymer-MSNs interacted through the Schiff base bond, which possessed a mildly acidic responsive property. Interestingly, the assembled system could rapidly respond and release guest molecules inside cancer cells. This would make the entrapped drug released before the carriers escape from the endosome counterpart. The results show that the assembled composite complexes can be considered to be a drug delivery system for cancer therapy.
authors.affiliation: CAS Key Laboratory for Biological Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology , Beijing 100190, China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Yang
authors.affiliation: Department of Chemistry and Biochemistry, Freie Universität Berlin , Takustrasse 3, 14195 Berlin, Germany.
authors.forename: Katharina
authors.initials: K
authors.lastname: Achazi
authors.affiliation: Beijing National Laboratory for Molecular Sciences (BNLMS), Key Laboratory of Colloid and Interface Science, Institute of Chemistry, Chinese Academy of Sciences (CAS) , Beijing 100190, China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Jia
authors.affiliation: Department of Chemistry and Biochemistry, Freie Universität Berlin , Takustrasse 3, 14195 Berlin, Germany.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Wei
authors.affiliation: Department of Chemistry and Biochemistry, Freie Universität Berlin , Takustrasse 3, 14195 Berlin, Germany.
authors.forename: Rainer
authors.initials: R
authors.lastname: Haag
authors.affiliation: CAS Key Laboratory for Biological Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology , Beijing 100190, China.|Beijing National Laboratory for Molecular Sciences (BNLMS), Key Laboratory of Colloid and Interface Science, Institute of Chemistry, Chinese Academy of Sciences (CAS) , Beijing 100190, China.
authors.forename: Junbai
authors.initials: J
authors.lastname: Li
mesh_terms: D000072283:A549 Cells; D003432:Cross-Linking Reagents; D004337:Drug Carriers / Q000737:chemistry*; D016503:Drug Delivery Systems; D004705:Endocytosis; D005456:Fluorescent Dyes / Q000008:administration & dosage / Q000493:pharmacokinetics; D005990:Glycerol / Q000737:chemistry; D006801:Humans; D006863:Hydrogen-Ion Concentration; D018613:Microscopy, Confocal; D046529:Microscopy, Electron, Transmission; D053758:Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D036103:Nanotechnology; D009369:Neoplasms / Q000188:drug therapy; D011108:Polymers / Q000737:chemistry; D012235:Rhodamines / Q000008:administration & dosage / Q000493:pharmacokinetics; D012545:Schiff Bases / Q000737:chemistry; D012822:Silicon Dioxide / Q000737:chemistry; D059016:Tumor Microenvironment
chemical_list: D003432:Cross-Linking Reagents; D004337:Drug Carriers; D005456:Fluorescent Dyes; D011108:Polymers; D012235:Rhodamines; D012545:Schiff Bases; C043941:polyglycerol; D012822:Silicon Dioxide; C029773:rhodamine B; D005990:Glycerol