title: TGF-β1 rs1982073 polymorphism contributes to radiation pneumonitis in lung cancer patients: a meta-analysis.
abstract: Transforming growth factor beta 1(TGF-β1) polymorphism was associated with radiation pneumonitis (RP) susceptibility, but their results have been inconsistent. The PubMed and CNKI were searched for case-control studies published up to Januray 01, 2016 was Data were extracted and pooled odds ratios (OR) with 95% confidence intervals (CI) were calculated. In this meta-analysis, we assessed eight publications involving 368 radiation pneumonitis cases and 855 controls of the association between TGF-β1 T869C (rs1982073) and G915C (rs1800471) polymorphism and RP susceptibility. Our analysis suggested that TGF-β1 T869C rs1982073 polymorphism was associated with lower RP risk for CT combined CC versus TT model (OR = 0.58, 95% CI = 0.43-0.77). However, for the G915C rs1800471 polymorphism, no association was found between the polymorphism and the susceptibility to RP in GC combined CC versus GG model (OR = 0.82, 95% CI = 0.50-1.35). These results from the meta-analysis suggest that T869C rs1982073 polymorphism of TGF-β1 may be associated with RP risk, and there may be no association between G915C polymorphism and RP risk.
authors.affiliation: Department of Radiation Oncology, Jinling Hospital, Medical School of Nanjing University, Nanjing, China.
authors.forename: Ze-Tian
authors.initials: ZT
authors.lastname: Shen
authors.affiliation: Department of Radiation Oncology, Jinling Hospital, Medical School of Nanjing University, Nanjing, China.
authors.forename: Jun-Shu
authors.initials: JS
authors.lastname: Shen
authors.affiliation: Department of Radiation Oncology, Jinling Hospital, Medical School of Nanjing University, Nanjing, China.
authors.forename: Xiao-Qin
authors.initials: XQ
authors.lastname: Ji
authors.affiliation: Department of Radiation Oncology, Jinling Hospital, Medical School of Nanjing University, Nanjing, China.
authors.forename: Bing
authors.initials: B
authors.lastname: Li
authors.affiliation: Department of Radiation Oncology, Jinling Hospital, Medical School of Nanjing University, Nanjing, China.
authors.forename: Xi-Xu
authors.initials: XX
authors.lastname: Zhu
mesh_terms: D016022:Case-Control Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D008175:Lung Neoplasms / Q000150:complications* / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D017594:Publication Bias; D017564:Radiation Pneumonitis / Q000150:complications* / Q000235:genetics*; D012307:Risk Factors; D053773:Transforming Growth Factor beta1 / Q000235:genetics*
chemical_list: D053773:Transforming Growth Factor beta1
keywords: TGF-β1; lung cancer; meta-analysis; polymorphism; radiation pneumonitis