title: The correlation of clinical and chromosomal alterations of benign meningiomas and their recurrences.
abstract: Meningiomas (MGs) are the frequent benign intracranial tumors. Their complete removal does not always guarantee relapse-free survival. Recurrence-associated chromosomal anomalies in MGs haves been proposed as prognostic factors in addition to the World Health Organisation (WHO) grading, tumor size and resection rate. The aim of this study was to evaluate the frequency of deletions on chromosomes in sporadic MGs and to correlate them with the clinical findings and tumor behaviour. Along with survival, the tumor recurrence was the main endpoint. Chromosomal loss of heterozygosity (LOH) was studied. 46 benign MGs were subjected to the analysis, complete tumor resection was intended and no early mortalities were observed. Incomplete removal was related to parasagittal location and psammomatous hisptopathology (p<0.01). Chromosomal alterations were present in 82.6% of cases; LOH at 22q (67.4%) and 1p (34.8%) were the most frequent and associated with male sex (p=0.04). Molecular findings were not specific for any of the histopathologic grade. Tumor recurrence (14 of 46) correlated with tumor size (≥35mm), LOH at 1p, 14q, coexistence of LOH at 1p/14q, 10q/14q, 'complex karyotype' status (≥2 LOHs excluding 22q), patient age (younger <35), and Simpson grading of resection rate (≥3 of worse prognosis). The last 3 variables were independent significant prognostic factors in multivariate analysis and of the same importance in recurrence prediction (Receiver Operating Characteristic curves comparison p>0.05). Among the cases of recurrence, tumor progression was observed in 3 of 14. In 2 cases, LOH on 1p and/or coexistence of LOH 1p/14q correlated with anaplastic transformation.
authors.affiliation: Neurosurgery Department, Regional Specialist Hospital, Olsztyn, Poland.
authors.forename: Waldemar
authors.initials: W
authors.lastname: Och
authors.affiliation: Neurosurgery Department, Medical University of Gdansk, Gdansk, Poland. Electronic address: tszmuda@gumed.edu.pl.
authors.forename: Tomasz
authors.initials: T
authors.lastname: Szmuda
authors.affiliation: Neurosurgery Department, Regional Specialist Hospital, Olsztyn, Poland.
authors.forename: Kamil
authors.initials: K
authors.lastname: Kulbacki
authors.affiliation: Neurosurgery Department, Regional Specialist Hospital, Olsztyn, Poland.
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Witek
authors.affiliation: Department of Molecular Pathology and Neuropathology, Medical University of Łódź, Łódź, Poland.
authors.forename: Beata
authors.initials: B
authors.lastname: Sikorska
authors.affiliation: Department of Molecular Pathology and Neuropathology, Medical University of Łódź, Łódź, Poland.
authors.forename: Magdalena
authors.initials: M
authors.lastname: Zakrzewska
authors.affiliation: Department of Preventive Medicine and Education, Medical University of Gdańsk, Gdańsk, Poland.
authors.forename: Janusz
authors.initials: J
authors.lastname: Springer
authors.affiliation: Department of Medical Pathomorphology, Medical University of Białystok, Białystok, Poland.
authors.forename: Joanna
authors.initials: J
authors.lastname: Reszeć
authors.affiliation: Neurosurgery Department, Regional Specialist Hospital, Olsztyn, Poland.
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Parda
authors.affiliation: Department of Molecular Pathology and Neuropathology, Medical University of Łódź, Łódź, Poland.
authors.forename: Paweł P
authors.initials: PP
authors.lastname: Liberski
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D002869:Chromosome Aberrations; D002872:Chromosome Deletion; D018450:Disease Progression; D005260:Female; D006801:Humans; D019656:Loss of Heterozygosity / Q000235:genetics*; D008297:Male; D008577:Meningeal Neoplasms / Q000235:genetics* / Q000473:pathology / Q000601:surgery; D008579:Meningioma / Q000235:genetics* / Q000473:pathology / Q000601:surgery; D008875:Middle Aged; D060787:Neoplasm Grading; D009364:Neoplasm Recurrence, Local / Q000235:genetics*; D011379:Prognosis; D012372:ROC Curve; D012737:Sex Factors; D015996:Survival Rate; D055815:Young Adult
keywords: LOH; Loss of heterozygosity; Meningioma; Tumour recurrence