title: The protective effect of infliximab against carbon tetrachloride-induced acute lung injury.
abstract: OBJECTIVE
  Carbon tetrachloride (CCl4) causes pulmonary toxicity. Infliximab (Ib) is a potent inhibitor of tumor necrosis factor-alpha (TNF-α). We aimed to investigate whether Ib has a protective effect on CCl4 induced lung injury.
  
  
  METHODS
  Rats were divided into control, CCl4, and CCl4+Ib groups. A single dose of 2 ml/kg CCI4 was administered to CCI4 group and a single dose of 7 mg/kg Ib was given to CCl4+Ib group 24 hr before applying CCI4.
  
  
  RESULTS
  TNF-α, malondialdehyde (MDA), nitric oxide (NO) and caspase-3 levels of the CCl4 group were markedly higher than both the control and CCl4+Ib groups. The CCI4+Ib group had lower histopathological injury than the CCl4 group.
  
  
  CONCLUSIONS
  Ib as a strong TNF-α blocker decreases the production of proinflammatory cytokines, MDA, and oxidative stress leading to a protective effect against CCl4 induced lung tissue injury.
authors.affiliation: Recep Tayyip Erdogan University, School of Medicine, Department of Thoracic Surgery, Rize, Turkey.
authors.forename: Aysel
authors.initials: A
authors.lastname: Kurt
authors.affiliation: Recep Tayyip Erdogan University, School of Medicine, Department of Histology and Embryology, Rize, Turkey.
authors.forename: Levent
authors.initials: L
authors.lastname: Tumkaya
authors.affiliation: Department of Internal Medicine, Ordu Kumru State Hospital, Ordu, Turkey.
authors.forename: Suleyman
authors.initials: S
authors.lastname: Yuce
authors.affiliation: Recep Tayyip Erdogan University, School of Medicine, Department of Thoracic Surgery, Rize, Turkey.
authors.forename: Hasan
authors.initials: H
authors.lastname: Turut
authors.affiliation: Recep Tayyip Erdogan University, School of Medicine, Department of Biochemistry, Rize, Turkey.
authors.forename: Medine Cumhur
authors.initials: MC
authors.lastname: Cure
authors.affiliation: Recep Tayyip Erdogan University, School of Medicine, Department of Pathology, Rize, Turkey.
authors.forename: Ibrahim
authors.initials: I
authors.lastname: Sehitoglu
authors.affiliation: Recep Tayyip Erdogan University, School of Medicine, Department of Histology and Embryology, Rize, Turkey.
authors.forename: Yildiray
authors.initials: Y
authors.lastname: Kalkan
authors.affiliation: Recep Tayyip Erdogan University, School of Medicine, Department of Internal Medicine, Rize, Turkey.
authors.forename: Gokhan
authors.initials: G
authors.lastname: Pusuroglu
authors.affiliation: Recep Tayyip Erdogan University, School of Medicine, Department of Internal Medicine, Rize, Turkey.
authors.forename: Erkan
authors.initials: E
authors.lastname: Cure
keywords: Carbon tetrachloride; Infliximab; Nitric oxide; Oxidative stress; Pulmonary toxicity