title: MiR-329 suppresses osteosarcoma development by downregulating Rab10.
abstract: MiR-329 has been proved to be a tumor suppressor gene in various malignancies, however, its role in osteosarcoma remains elusive. We found that miR-329 is remarkably downregulated in osteosarcoma tissues and relates to advanced stages. MiR-329 is able to inhibit osteosarcoma cell proliferation, promote apoptosis, and induce G0/G1 cell cycle arrest. In addition, miR-329 also suppresses wound-healing and migration ability of osteosarcoma cells and inhibits tumorigenicity in vivo. Rab10 was identified as a target of miR-329 in osteosarcoma and mediates its biofunction. These findings may shed light to the understanding of tumor development in osteosarcoma.
authors.affiliation: Department of Orthopedics, Shanghai Tenth People's Hospital, Tong Ji University School of Medicine, China.
authors.forename: Wenwei
authors.initials: W
authors.lastname: Jiang
authors.affiliation: Department of Orthopedics, Wuxi Taihu Hospital, China.
authors.forename: Jin
authors.initials: J
authors.lastname: Liu
authors.affiliation: Department of Orthopedics, Shanghai Tenth People's Hospital, Tong Ji University School of Medicine, China.
authors.forename: Tianyang
authors.initials: T
authors.lastname: Xu
authors.affiliation: Department of Orthopedics, Suzhou Municipal Hospital of Nanjing Medical University, China.
authors.forename: Xiao
authors.initials: X
authors.lastname: Yu
mesh_terms: D017209:Apoptosis / Q000235:genetics; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000235:genetics; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D035683:MicroRNAs / Q000096:biosynthesis / Q000235:genetics*; D012516:Osteosarcoma / Q000235:genetics* / Q000473:pathology; D020691:rab GTP-Binding Proteins / Q000096:biosynthesis* / Q000235:genetics
chemical_list: C584396:MIRN329 microRNA, human; D035683:MicroRNAs; C538901:Rab10 protein, human; D020691:rab GTP-Binding Proteins
keywords: Rab10; growth; miR-329; migration; osteosarcoma