title: (IPr)CuF-catalyzed α-site regiocontrolled trans-hydrofluorination of ynamides.
abstract: With Et3N·3HF as the fluorination reagent, (IPr)CuF-catalyzed α-site regiocontrolled trans-hydrofluorination of ynamides has been achieved, affording (Z)-α-fluoroenamides in moderate to excellent yields. It was interesting to note that the regioselectivity of the reaction is reversed to that observed in the (Ph3P)3CuF-catalyzed hydrofluorination of ynamides. Additionally, a variety of different ynamides including oxazolidinonyl-, imidazolyl-, and N-sulfonyl ynamides were suitable for the reaction system and the subsequent oxidation of the fluorinated products enables a convenient synthesis to α-fluoroimides.
authors.affiliation: Department of Applied Chemistry, College of Chemistry and Molecular Engineering, Nanjing Tech University, Nanjing 211816, People' s Republic of China. hegk@njtech.edu.cn zhuhj@njtech.edu.cn.
authors.forename: Guohao
authors.initials: G
authors.lastname: Zhu
authors.affiliation: Department of Applied Chemistry, College of Chemistry and Molecular Engineering, Nanjing Tech University, Nanjing 211816, People' s Republic of China. hegk@njtech.edu.cn zhuhj@njtech.edu.cn.
authors.forename: Shineng
authors.initials: S
authors.lastname: Qiu
authors.affiliation: Department of Applied Chemistry, College of Chemistry and Molecular Engineering, Nanjing Tech University, Nanjing 211816, People' s Republic of China. hegk@njtech.edu.cn zhuhj@njtech.edu.cn.
authors.forename: Yang
authors.initials: Y
authors.lastname: Xi
authors.affiliation: Department of Applied Chemistry, College of Chemistry and Molecular Engineering, Nanjing Tech University, Nanjing 211816, People' s Republic of China. hegk@njtech.edu.cn zhuhj@njtech.edu.cn.
authors.forename: Yao
authors.initials: Y
authors.lastname: Ding
authors.affiliation: Department of Applied Chemistry, College of Chemistry and Molecular Engineering, Nanjing Tech University, Nanjing 211816, People' s Republic of China. hegk@njtech.edu.cn zhuhj@njtech.edu.cn.
authors.forename: Dongming
authors.initials: D
authors.lastname: Zhang
authors.affiliation: Department of Applied Chemistry, College of Chemistry and Molecular Engineering, Nanjing Tech University, Nanjing 211816, People' s Republic of China. hegk@njtech.edu.cn zhuhj@njtech.edu.cn.
authors.forename: Rong
authors.initials: R
authors.lastname: Zhang
authors.affiliation: Department of Applied Chemistry, College of Chemistry and Molecular Engineering, Nanjing Tech University, Nanjing 211816, People' s Republic of China. hegk@njtech.edu.cn zhuhj@njtech.edu.cn.
authors.forename: Guangke
authors.initials: G
authors.lastname: He
authors.affiliation: Department of Applied Chemistry, College of Chemistry and Molecular Engineering, Nanjing Tech University, Nanjing 211816, People' s Republic of China. hegk@njtech.edu.cn zhuhj@njtech.edu.cn.
authors.forename: Hongjun
authors.initials: H
authors.lastname: Zhu