title: A current snapshot of common genomic variants contribution in psychiatric disorders.
abstract: In the past decade, numerous advances were achieved in psychiatric genetics. Particularly, the genome wide association studies (GWAS) have contributed to uncovering new genes and pathways associated to psychiatric disorders (PDs). At the same time, with increasing sample sizes in the GWAS, the polygenic risk score (PRS) promoted an additional tool for identification and evaluation the genetic risk quantitatively in PDs. This concept review presents the state of the art GWAS analysis and PRS focusing on the genetic underpinnings of PDs. © 2016 Wiley Periodicals, Inc.
authors.affiliation: Interdisciplinary Laboratory of Clinical Neurosciences, Federal University of Sao Paulo (UNIFESP), Sao Paulo, SP, Brazil.|Department of Psychiatry, Federal University of Sao Paulo (UNIFESP), Sao Paulo, SP, Brazil.|Genetics Division, Federal University of Sao Paulo (UNIFESP), Sao Paulo, SP, Brazil.
authors.forename: Marcos L
authors.initials: ML
authors.lastname: Santoro
authors.affiliation: Interdisciplinary Laboratory of Clinical Neurosciences, Federal University of Sao Paulo (UNIFESP), Sao Paulo, SP, Brazil.|Department of Psychiatry, Federal University of Sao Paulo (UNIFESP), Sao Paulo, SP, Brazil.|Genetics Division, Federal University of Sao Paulo (UNIFESP), Sao Paulo, SP, Brazil.
authors.forename: Patricia N
authors.initials: PN
authors.lastname: Moretti
authors.affiliation: Center for Applied Genomics, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.
authors.forename: Renata
authors.initials: R
authors.lastname: Pellegrino
authors.affiliation: Interdisciplinary Laboratory of Clinical Neurosciences, Federal University of Sao Paulo (UNIFESP), Sao Paulo, SP, Brazil.|Department of Psychiatry, Federal University of Sao Paulo (UNIFESP), Sao Paulo, SP, Brazil.
authors.forename: Ary
authors.initials: A
authors.lastname: Gadelha
authors.affiliation: Interdisciplinary Laboratory of Clinical Neurosciences, Federal University of Sao Paulo (UNIFESP), Sao Paulo, SP, Brazil.|Department of Psychiatry, Federal University of Sao Paulo (UNIFESP), Sao Paulo, SP, Brazil.|Department of Pharmacology, Federal University of Sao Paulo (UNIFESP), Sao Paulo, SP, Brazil.
authors.forename: Vanessa C
authors.initials: VC
authors.lastname: Abílio
authors.affiliation: Interdisciplinary Laboratory of Clinical Neurosciences, Federal University of Sao Paulo (UNIFESP), Sao Paulo, SP, Brazil.|Department of Psychiatry, Federal University of Sao Paulo (UNIFESP), Sao Paulo, SP, Brazil.|Department of Pharmacology, Federal University of Sao Paulo (UNIFESP), Sao Paulo, SP, Brazil.
authors.forename: Mirian A F
authors.initials: MA
authors.lastname: Hayashi
authors.affiliation: Interdisciplinary Laboratory of Clinical Neurosciences, Federal University of Sao Paulo (UNIFESP), Sao Paulo, SP, Brazil.|Department of Psychiatry, Federal University of Sao Paulo (UNIFESP), Sao Paulo, SP, Brazil.|Genetics Division, Federal University of Sao Paulo (UNIFESP), Sao Paulo, SP, Brazil.
authors.forename: Sintia I
authors.initials: SI
authors.lastname: Belangero
authors.affiliation: Center for Applied Genomics, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.
authors.forename: Hakon
authors.initials: H
authors.lastname: Hakonarson
mesh_terms: D020022:Genetic Predisposition to Disease / Q000235:genetics; D014644:Genetic Variation; D055106:Genome-Wide Association Study / Q000379:methods; D023281:Genomics; D006801:Humans; D001523:Mental Disorders / Q000235:genetics* / Q000523:psychology; D020412:Multifactorial Inheritance / Q000235:genetics; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D012307:Risk Factors
keywords: GWAS; polygenic risk score; psychiatric disorder; psychiatry