title: Investigation of Dysregulation of Several MicroRNAs in Peripheral Blood of Schizophrenia Patients.
abstract: OBJECTIVE
  The prevalence of schizophrenia is 1%, and it is a debilitating disorder that often results in a shortened lifespan. Peripheral blood samples are good candidates to investigate because they can be easily drawn, and they are widely studied in psychiatric disorders. MicroRNAs are small non-coding RNA transcripts. They regulate the expression of genes by binding to the 3'-untranslated region (UTR) of mRNAs and pointing them to degrade. In this study, we aimed to investigate the expression of miR-9-5p, miR-29a-3p, miR-106-5p, miR-106b-5p, miR-107, miR-125a-3p, and miR-125b-3p in schizophrenia patients and healthy controls.
  
  
  METHODS
  We collected blood samples from 16 patients with schizophrenia and 16 healthy controls. MicroRNAs were measured with reverse transcriptase polymerase chain reaction.
  
  
  RESULTS
  Schizophrenia patients showed statistically significant upregulation of five microRNAs: miR9-5p (p=0.002), miR29a-3p (p＜0.001), miR106b-5p (p=0.002), miR125a-3p (p＜0.001), and miR125b-3p (p=0.018).
  
  
  CONCLUSIONS
  Our results increased the value of the miR106 and miR29 families as potentially and consistently dysregulated in psychiatric disorders. Our results should be considered preliminary, and they need confirmation in future studies with larger sample sizes.
authors.affiliation: Psychiatry Clinic, Afşın State Hospital, Kahramanmaras, Turkey.
authors.forename: Mehmet Akif
authors.initials: MA
authors.lastname: Camkurt
authors.affiliation: Psychiatry Clinic, Harran University Teaching Hospital, Şanlıurfa, Turkey.
authors.forename: Fatih
authors.initials: F
authors.lastname: Karababa
authors.affiliation: Department of Medical Biology, Faculty of Medicine, Mersin University, Mersin, Turkey.
authors.forename: Mehmet Emin
authors.initials: ME
authors.lastname: Erdal
authors.affiliation: Psychiatry Clinic, Siverek State Hospital, Şanlıurfa, Turkey.
authors.forename: Hüseyin
authors.initials: H
authors.lastname: Bayazıt
authors.affiliation: Psychiatry Clinic, Balıklıgöl State Hospital, Şanlıurfa, Turkey.
authors.forename: Sultan Basmacı
authors.initials: SB
authors.lastname: Kandemir
authors.affiliation: Department of Medical Biology, Faculty of Medicine, Mersin University, Mersin, Turkey.
authors.forename: Mustafa Ertan
authors.initials: ME
authors.lastname: Ay
authors.affiliation: Department of Child and Adolescent Psychiatry, Harran University Teaching Hospital, Şanlıurfa, Turkey.
authors.forename: Hasan
authors.initials: H
authors.lastname: Kandemir
authors.affiliation: Department of Medical Biology, Faculty of Medicine, Mersin University, Mersin, Turkey.
authors.forename: Özlem İzci
authors.initials: Öİ
authors.lastname: Ay
authors.affiliation: Psychiatry Clinic, Çumra State Hospital, Konya, Turkey.
authors.forename: Erdinç
authors.initials: E
authors.lastname: Çiçek
authors.affiliation: Department of Psychiatry and Behavioral Sciences, Harris County Psychiatric Center, University of Texas, Houston, TX, USA.
authors.forename: Salih
authors.initials: S
authors.lastname: Selek
authors.affiliation: Department of Biostatistics, Mersin University, Mersin, Turkey.
authors.forename: Bahar
authors.initials: B
authors.lastname: Taşdelen
keywords: Blood; Genes; MicroRNAs; Schizophrenia