title: The role of CXCR3 and its ligands in renal transplant outcome.
abstract: Chemokines and their corresponding receptors serve as pro-inflammatory and migratory signals for immune cells. CXCR3 and its corresponding ligands, CXCL9, CXCL10 and CXCL11, participate in the induction of immune responses against several foreign antigens. Numerous cells, including macrophages, NK cells and T lymphocytes, express CXCR3 and thus, expression of the receptor and its ligands can induce activity of these important immune cells against foreign antigens, including allogeneic grafts. Several parameters of the immune system participate in the induction and stimulation of powerful immune responses against allogeneic grafts. A thorough understanding of the parameters that regulate these responses can provide insights into new methods for immunotherapy during organ transplantation. The aim of this review is to address the most recent information regarding the roles played by CXCR3 and its corresponding ligands in the outcome of renal transplantation.
authors.affiliation: Pathology and Stem cell Research center, Department of Pathology, Afzalipour School of Medicine, Kerman University of Medical Sciences, Kerman, Iran.
authors.forename: Shahriar
authors.initials: S
authors.lastname: Dabiri
authors.affiliation: Department of Microbiology, Kerman Branch, Islamic Azad University, Kerman, Iran, Branch, Islamic Azad University, Kerman, Iran.
authors.forename: Ashraf
authors.initials: A
authors.lastname: Kariminik
authors.affiliation: School of Natural Sciences, Eskitis Institute for Drug Discovery, Griffith University, Nathan, Queensland, Australia.
authors.forename: Derek
authors.initials: D
authors.lastname: Kennedy
mesh_terms: D000818:Animals; D019743:Chemokines, CXC / Q000235:genetics / Q000378:metabolism; D006084:Graft Rejection; D006085:Graft Survival / Q000235:genetics / Q000276:immunology; D006801:Humans; D007674:Kidney Diseases / Q000235:genetics / Q000378:metabolism / Q000628:therapy; D016030:Kidney Transplantation; D008024:Ligands; D054367:Receptors, CXCR3 / Q000235:genetics / Q000378:metabolism*; D016176:T-Lymphocyte Subsets / Q000276:immunology / Q000378:metabolism; D016896:Treatment Outcome
chemical_list: D019743:Chemokines, CXC; D008024:Ligands; D054367:Receptors, CXCR3