title: Bisphosphonate treatment and dental implants: A systematic review.
abstract: BACKGROUND
  To analyze articles that studied patients submitted to diphosphonates therapy and who received dental implants before, during or after bisphosphonate (BP) treatment, compared to healthy patients, analyzing the increase of failure and loss of implants or bisphosphonate related osteonecrosis of the jaw (BRONJ) incidence.
  
  
  METHODS
  The Preferred Reporting Items for Systematic Reviews and Meta-analysis (PRISMA) statement was used in this study. The clinical question in "PICO" format was: In patients under bisphosphonate therapy, do dental implants placement, compared to healthy patients, increase the failure and loss of implants or bisphosphonate related osteonecrosis of the jaw incidence? PubMed/MEDLINE was searched for articles published up until April 15, 2015 using a combination of MeSH terms and their Entry terms.
  
  
  RESULTS
  The search resulted in 375 articles. After selection according to the eligibility criteria, 15 studies fulfilled were included (eight retrospective, one prospective and six case series), with a total of 1339 patients analyzed, 3748 implants placed, 152 loss of implants and 78 cases of BRONJ.
  
  
  CONCLUSIONS
  Due to the lack of randomized clinical trials looking at this theme, further studies with longer follow-up are needed to elucidate the remaining questions. Thus, it is wise to be careful when planning dental implant surgery in patients undergoing bisphosphonate therapy because of the risk of developing BRONJ as well as occurring failure of implant. Moreover, complete systemic condition of the patient must be also taking into considering when such procedures are performed.
authors.affiliation: Area of Oral & Maxillofacial Surgery, and Implantology, School of Dentistry, Federal University of Uberlândia, Avenida Pará, 1720, bloco 4T, CEP 38405-900 Uberlândia, Minas Gerais, Brazil, liviabonjardim@hotmail.com.
authors.forename: N-R
authors.initials: NR
authors.lastname: de-Freitas
authors.forename: L-B
authors.initials: LB
authors.lastname: Lima
authors.forename: M-B
authors.initials: MB
authors.lastname: de-Moura
authors.forename: C-C-F
authors.initials: CC
authors.lastname: Veloso-Guedes
authors.forename: P-C
authors.initials: PC
authors.lastname: Simamoto-Júnior
authors.forename: D
authors.initials: D
authors.lastname: de-Magalhães
mesh_terms: D050071:Bone Density Conservation Agents / Q000627:therapeutic use*; D015921:Dental Implants; D004164:Diphosphonates / Q000627:therapeutic use*; D006801:Humans; D011446:Prospective Studies; D012189:Retrospective Studies
chemical_list: D050071:Bone Density Conservation Agents; D015921:Dental Implants; D004164:Diphosphonates