title: Revisiting the scissor-like mechanism of activation for the erythropoietin receptor.
abstract: An interpretation of alternative crystal structures of the erythropoietin receptor, with and without ligand, led to the proposal of a scissor-like mechanism of activation. This model has been propagated in the literature and is still being used to interpret crystal structures of related type-I cytokine receptors. Here, we assess whether the model remains compatible with current knowledge on the family of type-I cytokine receptors, and consider whether the model, as initially presented, is truly supported by the crystal structures on which it was originally based.
authors.affiliation: School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Australia.
authors.forename: Michael S P
authors.initials: MS
authors.lastname: Corbett
authors.affiliation: School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Australia.
authors.forename: David
authors.initials: D
authors.lastname: Poger
authors.affiliation: School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Australia. a.e.mark@uq.edu.au.|Institute for Molecular Bioscience, The University of Queensland, Brisbane, Australia. a.e.mark@uq.edu.au.
authors.forename: Alan E
authors.identifier: 0000-0001-5880-4798
authors.initials: AE
authors.lastname: Mark
mesh_terms: D000818:Animals; D006801:Humans; D056004:Molecular Dynamics Simulation; D000072417:Protein Domains; D017467:Receptors, Erythropoietin / Q000737:chemistry* / Q000378:metabolism; D015398:Signal Transduction
chemical_list: D017467:Receptors, Erythropoietin
keywords: X-ray crystallography; erythropoietin; receptor activation