title: Image-guided biopsy in primary lung cancer: Why, when and how.
abstract: Initial histopathological analysis of a pulmonary lesion is mandatory whenever a lung cancer is suspected in order to determine the optimal diagnostic strategy. Adequate material must be obtained for a definite histological diagnosis (preferable to a cytological one) and in some cases (mainly in adenocarcinoma) molecular analysis. The two main methods to obtain adequate biopsy samples are flexible bronchoscopy and computed tomography (CT)-guided lung biopsy. Flexible bronchoscopy is a valuable method for proximal tumors. On the other hand, CT-guided lung biopsy is more accurate for peripheral tumors. CT-guided lung biopsy is a reliable procedure that conveys a 90% sensitivity for the diagnosis of lung cancer. When performed in a secured environment after contraindications evaluation, its severe complications rate is low, mainly consisting of pneumothorax requiring chest tube placement and hemoptysis.
authors.affiliation: Department of Radiology, Inserm UMR_S1165, Paris Diderot University, Sorbonne Paris-Cité, AP-HP, Saint-Louis Hospital, 1, avenue Claude-Vellefaux, 75010 Paris, France. Electronic address: constancedemm@gmail.com.
authors.forename: C
authors.initials: C
authors.lastname: de Margerie-Mellon
authors.affiliation: Department of Radiology, Inserm UMR_S1165, Paris Diderot University, Sorbonne Paris-Cité, AP-HP, Saint-Louis Hospital, 1, avenue Claude-Vellefaux, 75010 Paris, France.
authors.forename: C
authors.initials: C
authors.lastname: de Bazelaire
authors.affiliation: Department of Radiology, Inserm UMR_S1165, Paris Diderot University, Sorbonne Paris-Cité, AP-HP, Saint-Louis Hospital, 1, avenue Claude-Vellefaux, 75010 Paris, France.
authors.forename: E
authors.initials: E
authors.lastname: de Kerviler
mesh_terms: D000230:Adenocarcinoma / Q000000981:diagnostic imaging / Q000473:pathology; D001999:Bronchoscopy; D006469:Hemoptysis / Q000209:etiology; D006801:Humans; D061705:Image-Guided Biopsy / Q000009:adverse effects / Q000379:methods*; D008168:Lung / Q000000981:diagnostic imaging / Q000473:pathology; D008175:Lung Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology*; D011030:Pneumothorax / Q000209:etiology; D012680:Sensitivity and Specificity; D014057:Tomography, X-Ray Computed / Q000379:methods*
keywords: Computed tomography; Image-guided biopsy; Lung biopsy; Lung cancer