title: Serum Sialic Acid Concentration and Content in ApoB-Containing Lipoproteins in Liver Diseases.
abstract: BACKGROUND
  The great significance for the metabolism of lipoproteins is the composition of carbohydrate chain of apolipoproteins, where sialic acid (SA) is located. In VILDL and LDL sialic acid is attached to apolipoprotein B. The sialylation of serum proteins including apolipoprotein B can be affected in the course of liver diseases. Therefore, the aim of this study was to assess the effect of liver diseases on the concentration and content of SA in ApoB-containing lipoproteins.
  
  
  METHODS
  The tested group consisted of 165 patients (118 males, 47 females) with liver diseases: alcoholic cirrhosis, non-alcoholic cirrhosis, chronic hepatitis, toxic hepatitis, chronic viral hepatitis, and liver cancer. ApoB-containing lipoproteins were isolated by a turbidimetric procedure and SA concentration was measured according to an enzymatic method.
  
  
  RESULTS
  There was a significant increase in the serum concentration of SA in ApoB-containing lipoproteins in viral hepatitis. Although the serum concentration of ApoB was not significantly different between specific liver diseases, the serum levels of SA in ApoB-containing lipoproteins appeared to be different. There is an association between SA concentration and triglycerides in alcoholic cirrhosis and viral hepatitis. Also, in viral hepatitis SA concentration correlated negatively with HDL-cholesterol. The content of SA in ApoB-containing lipoproteins in alcoholic cirrhosis and viral hepatitis was significantly higher than that in the control group, but did not differ between diseases.
  
  
  CONCLUSIONS
  This study may explain the variations in serum lipids and lipoproteins in liver diseases. It seems that the reason for these abnormalities is the changes in the concentration of sialic acid in ApoB-containing lipoproteins.
authors.forename: Monika
authors.initials: M
authors.lastname: Gudowska
authors.forename: Ewa
authors.initials: E
authors.lastname: Gruszewska
authors.forename: Bogdan
authors.initials: B
authors.lastname: Cylwik
authors.forename: Anatol
authors.initials: A
authors.lastname: Panasiuk
authors.forename: Robert
authors.initials: R
authors.lastname: Filisiak
authors.forename: Maciej
authors.initials: M
authors.lastname: Szmitkowski
authors.forename: Lech
authors.initials: L
authors.lastname: Chrostek
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D053299:Apolipoprotein B-100 / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D056486:Chemical and Drug Induced Liver Injury / Q000097:blood* / Q000175:diagnosis; D005260:Female; D006525:Hepatitis, Viral, Human / Q000097:blood* / Q000175:diagnosis; D006801:Humans; D008074:Lipoproteins / Q000097:blood*; D008103:Liver Cirrhosis / Q000097:blood* / Q000175:diagnosis; D008104:Liver Cirrhosis, Alcoholic / Q000097:blood / Q000175:diagnosis; D008113:Liver Neoplasms / Q000097:blood* / Q000175:diagnosis; D008297:Male; D008875:Middle Aged; D019158:N-Acetylneuraminic Acid / Q000097:blood*; D009391:Nephelometry and Turbidimetry; D055815:Young Adult
chemical_list: C569471:APOB protein, human; D053299:Apolipoprotein B-100; D015415:Biomarkers; D008074:Lipoproteins; D019158:N-Acetylneuraminic Acid