title: Herpesvirus Respiratory Infections in Immunocompromised Patients: Epidemiology, Management, and Outcomes.
abstract: Among immunocompromised individuals, members of the human Herpesviridae family are frequently encountered pathogens. Cytomegalovirus, herpes simplex virus 1 and 2, varicella zoster virus, Epstein-Barr virus, and human herpesvirus-6, -7, and -8 all establish latency after infection and can reactivate during periods of immunosuppression, leading to both direct and indirect adverse effects on the host including severe organ dysfunction as well as allograft rejection and loss after transplantation. While not all herpesviruses are primary respiratory pathogens, many of their manifestations include involvement of the respiratory tract. This article discusses the individual viruses, their epidemiology, and clinical manifestations as well as recommended treatment and preventive strategies.
authors.affiliation: Division of Infectious Diseases, Department of Medicine, Loyola University, Maywood, Illinois.
authors.forename: Gail E
authors.initials: GE
authors.lastname: Reid
authors.affiliation: Division of Pulmonary, Critical Care Medicine, Allergy, and Clinical Immunology, Department of Medicine, The David Geffen School of Medicine at University of California at Los Angeles, Los Angeles, California.
authors.forename: Joseph P
authors.initials: JP
authors.lastname: Lynch
authors.affiliation: Division of Pulmonary, Critical Care Medicine, Allergy, and Clinical Immunology, Department of Medicine, The David Geffen School of Medicine at University of California at Los Angeles, Los Angeles, California.
authors.forename: Samuel
authors.initials: S
authors.lastname: Weigt
authors.affiliation: Division of Pulmonary, Critical Care Medicine, Allergy, and Clinical Immunology, Department of Medicine, The David Geffen School of Medicine at University of California at Los Angeles, Los Angeles, California.
authors.forename: David
authors.initials: D
authors.lastname: Sayah
authors.affiliation: Division of Pulmonary, Critical Care Medicine, Allergy, and Clinical Immunology, Department of Medicine, The David Geffen School of Medicine at University of California at Los Angeles, Los Angeles, California.
authors.forename: John A
authors.initials: JA
authors.lastname: Belperio
authors.affiliation: Division of Infectious Diseases, Department of Medicine, Loyola University, Maywood, Illinois.
authors.forename: Shellee A
authors.initials: SA
authors.lastname: Grim
authors.affiliation: Division of Infectious Diseases, Department of Medicine, Loyola University, Maywood, Illinois.
authors.forename: Nina M
authors.initials: NM
authors.lastname: Clark
mesh_terms: D006566:Herpesviridae Infections / Q000150:complications / Q000453:epidemiology / Q000628:therapy; D006801:Humans; D016867:Immunocompromised Host; D012141:Respiratory Tract Infections / Q000150:complications / Q000453:epidemiology / Q000628:therapy / Q000821:virology*