title: Effects of Exogenous Carbon Monoxide Releasing Molecules on the Development of Zebrafish Embryos and Larvae.
abstract: The use of exogenous carbon monoxide releasing molecules (CORMs) provides promise for clinical application; however, the hazard potential of CORMs in vivo remains poorly understood. The developmental toxicity of CORM-3 was investigated by exposure to concentrations ranging from 6.25 to 400 μmol/L during 4-144 h post fertilization. Toxicity endpoints of mortality, spontaneous movement, heart rate, hatching rate, malformation, body length, and larval behavior were measured. CORM-3 disrupted the progression of zebrafish larval development at concentrations exceeding 50 μmol/L, resulting in embryonic developmental toxicity.
authors.affiliation: School/Hospital of Stomatology, Lanzhou University, Lanzhou 730000, Gansu, China.
authors.forename: Jing E
authors.initials: JE
authors.lastname: Song
authors.affiliation: Department of Medical Physics, Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000, Gansu, China; Key Laboratory of Heavy Ion Radiation Biology and Medicine, Chinese Academy of Sciences, Lanzhou 730000, Gansu, China; Key Laboratory of Heavy Ion Radiation Medicine of Gansu Province, Lanzhou 730000, Gansu, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Si
authors.affiliation: Department of Medical Physics, Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000, Gansu, China; Key Laboratory of Heavy Ion Radiation Biology and Medicine, Chinese Academy of Sciences, Lanzhou 730000, Gansu, China; Key Laboratory of Heavy Ion Radiation Medicine of Gansu Province, Lanzhou 730000, Gansu, China.
authors.forename: Rong
authors.initials: R
authors.lastname: Zhou
authors.affiliation: Gansu Medicinal College, Pingliang 744000, Gansu, China.
authors.forename: Hua Peng
authors.initials: HP
authors.lastname: Liu
authors.affiliation: School/Hospital of Stomatology, Lanzhou University, Lanzhou 730000, Gansu, China.
authors.forename: Zhen Guo
authors.initials: ZG
authors.lastname: Wang
authors.affiliation: Department of Medical Physics, Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000, Gansu, China; Key Laboratory of Heavy Ion Radiation Biology and Medicine, Chinese Academy of Sciences, Lanzhou 730000, Gansu, China; Key Laboratory of Heavy Ion Radiation Medicine of Gansu Province, Lanzhou 730000, Gansu, China.
authors.forename: Lu
authors.initials: L
authors.lastname: Gan
authors.affiliation: Lanzhou veolia Water(Group) Co., Ltd, Lanzhou 730000, Gansu, China.
authors.forename: Fang
authors.initials: F
authors.lastname: Gui
authors.affiliation: School/Hospital of Stomatology, Lanzhou University, Lanzhou 730000, Gansu, China.
authors.forename: Bin
authors.initials: B
authors.lastname: Liu
authors.affiliation: Department of Medical Physics, Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000, Gansu, China; Key Laboratory of Heavy Ion Radiation Biology and Medicine, Chinese Academy of Sciences, Lanzhou 730000, Gansu, China; Key Laboratory of Heavy Ion Radiation Medicine of Gansu Province, Lanzhou 730000, Gansu, China.
authors.forename: Hong
authors.initials: H
authors.lastname: Zhang
mesh_terms: D000818:Animals; D002248:Carbon Monoxide / Q000494:pharmacology; D002316:Cardiotonic Agents / Q000633:toxicity*; D004305:Dose-Response Relationship, Drug; D004625:Embryo, Nonmammalian / Q000187:drug effects; D047108:Embryonic Development / Q000187:drug effects*; D009942:Organometallic Compounds / Q000633:toxicity*; D015027:Zebrafish / Q000196:embryology* / Q000378:metabolism
chemical_list: D002316:Cardiotonic Agents; D009942:Organometallic Compounds; C476530:tricarbonylchloro(glycinato)ruthenium(II); D002248:Carbon Monoxide