title: Revisiting the Heterogeneous IFN-γ Response of Bacille of Calmette-Guérin (BCG)-Revaccinated Healthy Volunteers in a Randomized Controlled Trial: Effect of the Body Mass Index and of the IFNG+874 A/T Polymorphism.
abstract: In trials evaluating the immune responses to Bacille of Calmette-Guérin (BCG), the genetic background and the nutritional status are host-related factors that could affect the heterogeneity in these parameters. The IFNG+874 A/T (rs 62559044) polymorphism has been reported to influence the IFN-γ production by BCG-vaccinated individuals challenged in vitro with mycobacterial antigens. The body mass index (BMI) is a proxy for the nutritional status and has been associated both with the susceptibility to tuberculosis and with the IFN-γ response. We show that although the IFNG+874 A/T polymorphism was not associated with the heterogeneity of IFN-γ production in a randomized controlled trial that evaluated long-term immune responses to BCG revaccination previously conducted in Salvador, Bahia, Brazil, the effect of this polymorphism on the observed increase in IFN-γ production among revaccinated subjects was adjusted in individuals with a low BMI.
authors.affiliation: Universidade Federal da Bahia, Salvador, BA, Brazil.|Instituto Gonçalo Moniz, Fundação Oswaldo Cruz, Salvador, BA, Brazil.
authors.forename: Elisabete L
authors.initials: EL
authors.lastname: Conceição
authors.affiliation: Universidade Federal da Bahia, Salvador, BA, Brazil.
authors.forename: Francisco S
authors.initials: FS
authors.lastname: Nascimento-Sampaio
authors.affiliation: Universidade Federal da Bahia, Salvador, BA, Brazil.
authors.forename: Paulo A
authors.initials: PA
authors.lastname: Schwingel
authors.affiliation: Universidade Federal da Bahia, Salvador, BA, Brazil.|Instituto Gonçalo Moniz, Fundação Oswaldo Cruz, Salvador, BA, Brazil.
authors.forename: Evelin S
authors.initials: ES
authors.lastname: Oliveira
authors.affiliation: Instituto Gonçalo Moniz, Fundação Oswaldo Cruz, Salvador, BA, Brazil.
authors.forename: Michael S
authors.initials: MS
authors.lastname: Rocha
authors.affiliation: Instituto Gonçalo Moniz, Fundação Oswaldo Cruz, Salvador, BA, Brazil.|Escola Bahiana de Medicina e Saúde Pública, Salvador, BA, Brazil.
authors.forename: Igor
authors.initials: I
authors.lastname: Vieira
authors.affiliation: Universidade Federal da Bahia, Salvador, BA, Brazil.
authors.forename: Carlos M C
authors.initials: CM
authors.lastname: Mendes
authors.affiliation: Universidade Federal da Bahia, Salvador, BA, Brazil.
authors.forename: Adelmir
authors.initials: A
authors.lastname: Souza-Machado
authors.affiliation: Faculdade de Medicina, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
authors.forename: Martha M
authors.initials: MM
authors.lastname: Oliveira
authors.affiliation: Universidade Federal da Bahia, Salvador, BA, Brazil.|Instituto Gonçalo Moniz, Fundação Oswaldo Cruz, Salvador, BA, Brazil.
authors.forename: Manoel
authors.initials: M
authors.lastname: Barral-Netto
authors.affiliation: Escola Bahiana de Medicina e Saúde Pública, Salvador, BA, Brazil.|Hospital Santa Izabel, Salvador, BA, Brazil.
authors.forename: Jamocyr M
authors.initials: JM
authors.lastname: Marinho
authors.affiliation: Universidade Federal da Bahia, Salvador, BA, Brazil.|Instituto Gonçalo Moniz, Fundação Oswaldo Cruz, Salvador, BA, Brazil.
authors.forename: Theolis
authors.identifier: http://orcid.org/0000-0003-1928-0404
authors.initials: T
authors.lastname: Barbosa
mesh_terms: D001500:BCG Vaccine / Q000008:administration & dosage*; D015992:Body Mass Index; D001938:Brazil; D064368:Healthy Volunteers; D006801:Humans; D007117:Immunization, Secondary; D007371:Interferon-gamma / Q000096:biosynthesis* / Q000235:genetics; D015999:Multivariate Analysis; D011110:Polymorphism, Genetic
chemical_list: D001500:BCG Vaccine; D007371:Interferon-gamma