title: Reduced serum concentrations of brain-derived neurotrophic factor (BDNF) in transsexual Brazilian men.
abstract: Serum BDNF levels are significantly decreased in transsexual Brazilian women when compared to cis-sexual men. Since transsexual men are also exposed to chronic social stress and have a high prevalence of associated psychopathologies, it is plausible to inquire if BDNF serum levels are altered in transsexual men as well. Therefore, our objective was to evaluate differences in BDNF serum level of transsexual men when compared to cis-sexual men and women. Our sample comprises 27 transsexual men, 31 cis-sexual women and 30 cis-sexual men recruited between 2011 and 2015. We observed that BDNF serum concentration is decreased in transsexual men comparing to cis-sexual men and women. Cross-sex hormone treatment, chronic social stress or long-term gender dysphoria (GD) could explain the variation found in BDNF serum levels.
authors.affiliation: Department of Psychiatry/Hospital de Clínicas de Porto Alegre/Universidade Federal do Rio Grande do Sul Porto Alegre, Brazil. Electronic address: annamarthavf@gmail.com.
authors.forename: Anna Martha Vaitses
authors.initials: AMV
authors.lastname: Fontanari
authors.affiliation: Psychology Graduate Program, Pontifícia Universidade Católica do Rio Grande do Sul Porto Alegre, Brazil. Electronic address: angelobrandellicosta@gmail.com.
authors.forename: Angelo Brandelli
authors.initials: AB
authors.lastname: Costa
authors.affiliation: Department of Psychiatry/Hospital de Clínicas de Porto Alegre/Universidade Federal do Rio Grande do Sul Porto Alegre, Brazil. Electronic address: biancawaguiar@gmail.com.
authors.forename: Bianca
authors.initials: B
authors.lastname: Aguiar
authors.affiliation: Department of Endocrinology/Hospital de Clínicas de Porto Alegre/Universidade Federal do Rio Grande do Sul Porto Alegre, Brazil. Electronic address: cintiatusset@yahoo.com.br.
authors.forename: Cíntia
authors.initials: C
authors.lastname: Tusset
authors.affiliation: Department of Psychiatry/Hospital de Clínicas de Porto Alegre/Universidade Federal do Rio Grande do Sul Porto Alegre, Brazil. Electronic address: tahianasa@yahoo.com.br.
authors.forename: Tahiana
authors.initials: T
authors.lastname: Andreazza
authors.affiliation: Department of Psychiatry/Hospital de Clínicas de Porto Alegre/Universidade Federal do Rio Grande do Sul Porto Alegre, Brazil. Electronic address: maikoschneider@hcpa.edu.br.
authors.forename: Maiko
authors.initials: M
authors.lastname: Schneider
authors.affiliation: Department of Psychiatry/Hospital de Clínicas de Porto Alegre/Universidade Federal do Rio Grande do Sul Porto Alegre, Brazil. Electronic address: eduarda_dr@hotmail.com.
authors.forename: Eduarda Dias
authors.initials: ED
authors.lastname: da Rosa
authors.affiliation: Department of Psychiatry/Hospital de Clínicas de Porto Alegre/Universidade Federal do Rio Grande do Sul Porto Alegre, Brazil. Electronic address: biancasoll.psi@gmail.com.
authors.forename: Bianca Machado Borba
authors.initials: BMB
authors.lastname: Soll
authors.affiliation: Department of Psychiatry/Hospital de Clínicas de Porto Alegre/Universidade Federal do Rio Grande do Sul Porto Alegre, Brazil. Electronic address: karinesfono@hotmail.com.
authors.forename: Karine
authors.initials: K
authors.lastname: Schwarz
authors.affiliation: Department of Psychiatry/Hospital de Clínicas de Porto Alegre/Universidade Federal do Rio Grande do Sul Porto Alegre, Brazil. Electronic address: dhiordanc@gmail.com.
authors.forename: Dhiordan Cardoso
authors.initials: DC
authors.lastname: da Silva
authors.affiliation: Universidade Federal de Ciências da Saúde de Porto Alegre Porto Alegre, Brazil. Electronic address: b.andreoliveira@gmail.com.
authors.forename: André Oliveira
authors.initials: AO
authors.lastname: Borba
authors.affiliation: Department of Psychiatry/Hospital de Clínicas de Porto Alegre/Universidade Federal do Rio Grande do Sul Porto Alegre, Brazil. Electronic address: andressalaurenh@gmail.com.
authors.forename: Andressa
authors.initials: A
authors.lastname: Mueller
authors.affiliation: Department of Psychiatry / Universidade Federal do Paraná (UFPR) Porto Alegre, Brazil. Electronic address: rmassuda@gmail.com.
authors.forename: Raffael
authors.initials: R
authors.lastname: Massuda
authors.affiliation: Department of Psychiatry/Hospital de Clínicas de Porto Alegre Porto Alegre, Brazil. Electronic address: mirlobato@gmail.com.
authors.forename: Maria Inês Rodrigues
authors.initials: MIR
authors.lastname: Lobato
mesh_terms: D000328:Adult; D019208:Brain-Derived Neurotrophic Factor / Q000097:blood*; D001938:Brazil; D005260:Female; D006801:Humans; D008297:Male; D012737:Sex Factors; D014189:Transsexualism / Q000097:blood*
chemical_list: D019208:Brain-Derived Neurotrophic Factor; C579455:BDNF protein, human
keywords: BDNF; Gender dysphoria; Neurotrophin; Transgender; Transsexualism; Transsexuality