title: Interdigitating Reticulum Cell Sarcoma Positive immunohistochemistry for HLA-DR and two other activation antigens, CD30(Ki-1) and CD25(IL2R).
abstract: This communication reports a case of the rare interdigitating reticulum cell (IDRC) sarcoma of lymph nodes in a 46-year-old man. Extensive immunophenotypic analysis on paraffin and frozen sections revealed positivity on the neoplastic cells for protein S-100 as well as for antigens CD1, HLA-DR, CD4, CD25 (IL2R) and CD30 (Ki-1). The simultaneous positivity for the three activation antigens CD30, HLA-DR, and IL2R, a phenomenon mostly described in H and S-R cells of Hodgkin's disease, is discussed in particular.
authors.affiliation: a Departments of Pathology, School of Medicine, University of Ioannina, Ioannina, Greece.
authors.forename: C S
authors.initials: CS
authors.lastname: Papadimitriou
authors.affiliation: a Departments of Pathology, School of Medicine, University of Ioannina, Ioannina, Greece.
authors.forename: M C
authors.initials: MC
authors.lastname: Bai
authors.affiliation: a Departments of Pathology, School of Medicine, University of Ioannina, Ioannina, Greece.
authors.forename: D G
authors.initials: DG
authors.lastname: Stephanou
authors.affiliation: b Internal Medicine, School of Medicine, University of Ioannina, Ioannina, Greece.
authors.forename: N A
authors.initials: NA
authors.lastname: Pavlidis
authors.affiliation: a Departments of Pathology, School of Medicine, University of Ioannina, Ioannina, Greece.
authors.forename: S E
authors.initials: SE
authors.lastname: Athanasiadou
keywords: HLA-DR; IL2R; Immunohistochemistry activation antigens; Interdigitating cell sarcoma; Ki-1