title: Clinical Course and Outcomes of Late Kidney Allograft Dysfunction.
abstract: Background. This study is provided to increase the efficiency of the treatment of kidney transplant recipients by predicting the development of the late allotransplant dysfunction. Methods. 330 patients who have lived for more than one year with functioning kidney allograft were evaluated. To predict the subsequent duration of the well-functioning of allotransplant the prognostic significance of 15 baseline clinical and sociodemographic characteristics on the results of the survey one year after transplantation was investigated. The result was considered to be positive in constructing the regression prognostication model if recipient lived more than 3 years from the time of transplantation. Results. It was established that more late start of renal allograft dysfunction after transplantation correlates with the more time it takes till complete loss of allograft function. Creatinine and hemoglobin blood concentration and the level of proteinuria one year after transplantation within created mathematical model allow predicting the loss of kidney transplant function three years after the transplantation. Patients with kidney transplant dysfunction are advised to renew the program hemodialysis upon reaching plasma creatinine concentration 0.5-0.7 mmol/L. Conclusion. Values of creatinine, hemoglobin, and proteinuria one year after transplantation can be used for subsequent prognostication of kidney transplant function.
authors.affiliation: Transplant Center, Regional Hospital, Illyicha Avenue 14, Donetsk 83000, Ukraine.
authors.forename: Viktor
authors.identifier: 0000-0002-0144-1890
authors.initials: V
authors.lastname: Denisov
authors.affiliation: Transplant Center, Regional Hospital, Illyicha Avenue 14, Donetsk 83000, Ukraine.
authors.forename: Vadym
authors.initials: V
authors.lastname: Zakharov
authors.affiliation: Transplant Center, Regional Hospital, Illyicha Avenue 14, Donetsk 83000, Ukraine.
authors.forename: Anna
authors.initials: A
authors.lastname: Ksenofontova
authors.affiliation: Transplant Center, Regional Hospital, Illyicha Avenue 14, Donetsk 83000, Ukraine.
authors.forename: Eugene
authors.initials: E
authors.lastname: Onishchenko
authors.affiliation: Transplant Center, Regional Hospital, Illyicha Avenue 14, Donetsk 83000, Ukraine.
authors.forename: Tatyana
authors.initials: T
authors.lastname: Golubova
authors.affiliation: Transplant Center, Regional Hospital, Illyicha Avenue 14, Donetsk 83000, Ukraine.
authors.forename: Sergey
authors.initials: S
authors.lastname: Kichatyi
authors.affiliation: Transplant Center, Regional Hospital, Illyicha Avenue 14, Donetsk 83000, Ukraine.
authors.forename: Olga
authors.initials: O
authors.lastname: Zakharova