title: Extractive Atmospheric Pressure Photoionization (EAPPI) Mass Spectrometry: Rapid Analysis of Chemicals in Complex Matrices.
abstract: Extractive atmospheric pressure photoionization (EAPPI) mass spectrometry was designed for rapid qualitative and quantitative analysis of chemicals in complex matrices. In this method, an ultrasonic nebulization system was applied to sample extraction, nebulization, and vaporization. Mixed with a gaseous dopant, vaporized analytes were ionized through ambient photon-induced ion-molecule reactions, and were mass-analyzed by a high resolution time-of-flight mass spectrometer (TOF-MS). After careful optimization and testing with pure sample solution, EAPPI was successfully applied to the fast screening of capsules, soil, natural products, and viscous compounds. Analysis was completed within a few seconds without the need for preseparation. Moreover, the quantification capability of EAPPI for matrices was evaluated by analyzing six polycyclic aromatic hydrocarbons (PAHs) in soil. The correlation coefficients (R (2) ) for standard curves of all six PAHs were above 0.99, and the detection limits were in the range of 0.16-0.34 ng/mg. In addition, EAPPI could also be used to monitor organic chemical reactions in real time. Graphical Abstract ᅟ.
authors.affiliation: National Synchrotron Radiation Laboratory, University of Science and Technology of China, Hefei, 230029, China.
authors.forename: Chengyuan
authors.initials: C
authors.lastname: Liu
authors.affiliation: National Synchrotron Radiation Laboratory, University of Science and Technology of China, Hefei, 230029, China.
authors.forename: Jiuzhong
authors.initials: J
authors.lastname: Yang
authors.affiliation: Research and Development Centre, China Tobacco Anhui Industrial Co., Ltd., Hefei, 230088, China.
authors.forename: Jian
authors.initials: J
authors.lastname: Wang
authors.affiliation: Research and Development Centre, China Tobacco Anhui Industrial Co., Ltd., Hefei, 230088, China.
authors.forename: Yonghua
authors.initials: Y
authors.lastname: Hu
authors.affiliation: National Synchrotron Radiation Laboratory, University of Science and Technology of China, Hefei, 230029, China.
authors.forename: Wan
authors.initials: W
authors.lastname: Zhao
authors.affiliation: Power Machinery and Engineering of Ministry of Education, Shanghai Jiao Tong University, Shanghai, 200240, China.
authors.forename: Zhongyue
authors.initials: Z
authors.lastname: Zhou
authors.affiliation: Power Machinery and Engineering of Ministry of Education, Shanghai Jiao Tong University, Shanghai, 200240, China.
authors.forename: Fei
authors.initials: F
authors.lastname: Qi
authors.affiliation: National Synchrotron Radiation Laboratory, University of Science and Technology of China, Hefei, 230029, China. panyang@ustc.edu.cn.
authors.forename: Yang
authors.initials: Y
authors.lastname: Pan
keywords: Ambient ionization; Extractive atmospheric pressure photoionization; Mass spectrometry; Ultrasonic nebulization; Ultrasonic nebulization extraction