title: The SLC2A14 gene: genomic locus, tissue expression, splice variants, and subcellular localization of the protein.
abstract: The SLC2A14 gene encodes for GLUT14, an orphan member of the facilitated membrane glucose transporter family, which was originally described to be exclusively expressed in human testis. However, genetic variations in SLC2A14 are associated with chronic diseases such as Alzheimer's disease and Inflammatory Bowel Disease, which cannot be explained by a strictly testicular expression. Therefore we analyzed available information on the SLC2A14 gene to update knowledge of the locus and its encoded products. This report presents an expanded SLC2A14 gene locus and a more diverse tissue expression, concurring with the existing evidence for disease associations. The exon utilization is tissue specific, with major expression in testis. When the 2 major testicular protein isoforms were expressed in mammalian cells, they located to the plasmalemma membrane, providing early evidence that GLUT14 could function as a membrane transporter.
authors.affiliation: a Department of Human Nutritional Sciences, University of Manitoba, Winnipeg, MB R3T 2N2, Canada.
authors.forename: Mandana
authors.initials: M
authors.lastname: Amir Shaghaghi
authors.affiliation: b Department of Plant Science, University of Manitoba, Winnipeg, MB, Canada.
authors.forename: Brent
authors.initials: B
authors.lastname: Murphy
authors.affiliation: a Department of Human Nutritional Sciences, University of Manitoba, Winnipeg, MB R3T 2N2, Canada.
authors.forename: Peter
authors.initials: P
authors.lastname: Eck
mesh_terms: D017398:Alternative Splicing / Q000235:genetics*; D014644:Genetic Variation / Q000235:genetics*; D015894:Genome, Human; D023281:Genomics; D051246:Glucose Transport Proteins, Facilitative / Q000235:genetics* / Q000378:metabolism*; D006801:Humans; D020033:Protein Isoforms; D013347:Subcellular Fractions; D014018:Tissue Distribution
chemical_list: D051246:Glucose Transport Proteins, Facilitative; D020033:Protein Isoforms; C474630:SLC2A14 protein, human
keywords: GLUT14; SLC2A14