title: Serum malondialdehyde level and activity of total antioxidant status of dogs with age-related cataract.
abstract: OBJECTIVE
  determination of malondialdehyde (MDA) level and total antioxidant status (TAS) in the serum of dogs with age-related cataract.
  
  
  METHODS
  Forty dogs, 10-16 years of age, which were diagnosed with age-related cataract were examined. The control group consisted of 12 dogs, 8-13 years of age, without cataract. MDA was determined using a Perkin-Elmer LS 30 luminescence spectrometer using the method with thiobarbituric acid (TBA). TAS was determined using the colorimetric method with a set of Randox Total Antioxidant Status reagents.
  
  
  RESULTS
  The results show a higher level of MDA with statistically significant difference and lower activity of TAS in the serum of dogs with age-related cataract.
  
  
  CONCLUSIONS
  The results obtained indicate higher systemic lipid peroxidation and weakening of the general defense system in dogs with age-related cataract. These results suggest that such conditions may have an effect on the development of age-related cataract and are consistent with the theory of free radical age-related cataract development.
authors.forename: J
authors.initials: J
authors.lastname: Madany
mesh_terms: D000375:Aging; D000818:Animals; D000975:Antioxidants / Q000378:metabolism*; D002386:Cataract / Q000097:blood / Q000378:metabolism / Q000662:veterinary*; D004283:Dog Diseases; D004285:Dogs; D008315:Malondialdehyde / Q000097:blood*
chemical_list: D000975:Antioxidants; D008315:Malondialdehyde