title: FAMA: A Molecular Link between Stomata and Myrosin Cells.
abstract: Plants use sophisticated defense strategies against herbivores, including the myrosinase-glucosinolate system in Brassicales plants. This system sequesters myrosinase in myrosin cells, which are idioblasts in inner leaf tissues, and produces a toxic compound when cells are damaged by herbivores. Although the molecular mechanisms underlying myrosin cell development are largely unknown, recent studies have revealed that two key components, a basic helix-loop-helix (bHLH) transcription factor (FAMA) and vesicle trafficking factors (such as SYNTAXIN OF PLANTS 22), regulate the differentiation and fate determination of myrosin cells. FAMA also functions as a master regulator of guard cell (GC) differentiation. In this review, we discuss how FAMA operates two distinct genetic programs: the generation of myrosin cells in inner plant tissue and GCs in the epidermis.
authors.affiliation: Graduate School of Science, Kyoto University, Kyoto 606-8502, Japan.
authors.forename: Makoto
authors.initials: M
authors.lastname: Shirakawa
authors.affiliation: Graduate School of Science, Kyoto University, Kyoto 606-8502, Japan.
authors.forename: Haruko
authors.initials: H
authors.lastname: Ueda
authors.affiliation: Graduate School of Science, Kyoto University, Kyoto 606-8502, Japan.
authors.forename: Tomoo
authors.initials: T
authors.lastname: Shimada
authors.affiliation: Graduate School of Science, Kyoto University, Kyoto 606-8502, Japan. Electronic address: ihnishi@gr.bot.kyoto-u.ac.jp.
authors.forename: Ikuko
authors.initials: I
authors.lastname: Hara-Nishimura
mesh_terms: D051792:Basic Helix-Loop-Helix Proteins / Q000235:genetics / Q000502:physiology*; D019607:Brassicaceae / Q000166:cytology / Q000235:genetics / Q000502:physiology; D002454:Cell Differentiation / Q000235:genetics / Q000502:physiology; D018506:Gene Expression Regulation, Plant / Q000235:genetics / Q000502:physiology; D018515:Plant Leaves / Q000166:cytology* / Q000502:physiology; D010940:Plant Proteins / Q000502:physiology*; D054046:Plant Stomata / Q000502:physiology*
chemical_list: D051792:Basic Helix-Loop-Helix Proteins; D010940:Plant Proteins
keywords: FAMA; ICE1/SCREAM; bHLH transcription factor; cell differentiation; myrosin cell; stomata