title: Changes in Cognitive Function Following Bariatric Surgery: a Systematic Review.
abstract: Increased body mass is directly associated with reduced cognitive function. The aim of this study was to systematically review the effect of bariatric weight loss surgery on cognitive function. A comprehensive and unrestricted literature search was conducted using the following databases: MEDLINE, EMBASE, PubMed, Scopus, Web of Sciences, and the Cochrane Library. A total of 414 publications were identified, of which 18 were included in the final review. Cognitive function as measured by a number of different assessment tools was shown to improve following surgically induced weight loss in most studies. Significant and rapid weight loss resulting from bariatric surgery is associated with prompt and sustained improvements in cognitive function including memory, executive function, and cognitive control.
authors.affiliation: Department of Neurosciences, University Hospital of Wales, Cardiff and Vale University Health Board, Cardiff, CF14 4XW, UK. HandleyJ1@cardiff.ac.uk.
authors.forename: Joel D
authors.initials: JD
authors.lastname: Handley
authors.affiliation: Department of Medicine, Bronglais General Hospital, Hywel Dda University Health Board, Aberystwyth, SY23 1ER, UK.
authors.forename: David M
authors.initials: DM
authors.lastname: Williams
authors.affiliation: Welsh Institute of Metabolic and Obesity Surgery, Morriston Hospital, ABMU Health Board, Swansea, SA6 6NL, UK.
authors.forename: Scott
authors.initials: S
authors.lastname: Caplin
authors.affiliation: Diabetes Research Group, Institute of Life Sciences, College of Medicine, Swansea University, Swansea, SA2 8PP, UK.
authors.forename: Jeffrey W
authors.initials: JW
authors.lastname: Stephens
authors.affiliation: Welsh Institute of Metabolic and Obesity Surgery, Morriston Hospital, ABMU Health Board, Swansea, SA6 6NL, UK.
authors.forename: Jonathan
authors.initials: J
authors.lastname: Barry
mesh_terms: D050110:Bariatric Surgery / Q000523:psychology*; D003071:Cognition / Q000502:physiology*; D003072:Cognition Disorders / Q000209:etiology / Q000601:surgery*; D006801:Humans; D009765:Obesity / Q000150:complications / Q000523:psychology* / Q000601:surgery*; D015431:Weight Loss / Q000502:physiology*
keywords: Alzheimer’s; Alzheimer’s disease; Bariatric surgery; Cognition; Cognitive function; Dementia; Gastric band; Gastric bypass; Gastric surgery; Memory; Roux-en-Y; Sleeve gastrectomy and weight loss surgery; Systematic review