title: Protein expression of ATP-binding cassette transporters ABCC10 and ABCC11 associates with survival of colorectal cancer patients.
abstract: This study investigated the prognostic importance of protein expression of ATP-binding cassette (ABC) transporters ABCC10 and ABCC11 in colorectal cancer.
  
  
  
  Protein content of ABCC10 and ABCC11 was assessed in tumor tissue blocks of 140 colorectal cancer patients and associated with survival of patients with regard to 5-fluorouracil-based therapy.
  
  
  
  Low ABCC10 protein content in tumors increased hazard ratio of patient's death more than three times in comparison with high ABCC10-expressing tumors (P = 0.004). In contrast, the low ABCC11 content increased the hazard ratio of cancer recurrence in patients almost four times (P = 0.016). Analysis of patients treated with regimens based on 5-fluorouracil revealed that patients with low ABCC11 content in their tumors had shorter disease-free interval than those with higher content (P = 0.024).
  
  
  
  The present study shows for the first time that the protein expression of ABCC10 significantly associates with overall survival and the expression of ABCC11 with disease-free interval of colorectal cancer patients and provides strong impulse for further validation of their prognostic value in colorectal cancer.
authors.affiliation: Department of Histology and Embryology, Faculty of Medicine in Pilsen, Charles University in Prague, Pilsen, Czech Republic.
authors.forename: V
authors.initials: V
authors.lastname: Krizkova
authors.affiliation: Department of Pathology, Faculty Hospital and Faculty of Medicine in Pilsen, Charles University in Prague, Pilsen, Czech Republic.
authors.forename: M
authors.initials: M
authors.lastname: Dubova
authors.affiliation: Biomedical Centre, Faculty of Medicine in Pilsen, Charles University in Prague, Alej Svobody 76, 323 00, Pilsen, Czech Republic.
authors.forename: S
authors.initials: S
authors.lastname: Susova
authors.affiliation: Biomedical Centre, Faculty of Medicine in Pilsen, Charles University in Prague, Alej Svobody 76, 323 00, Pilsen, Czech Republic.|Deparment of Surgery, Faculty Hospital and Faculty of Medicine in Pilsen, Charles University in Prague, Pilsen, Czech Republic.
authors.forename: O
authors.initials: O
authors.lastname: Vycital
authors.affiliation: Biomedical Centre, Faculty of Medicine in Pilsen, Charles University in Prague, Alej Svobody 76, 323 00, Pilsen, Czech Republic.|Deparment of Surgery, Faculty Hospital and Faculty of Medicine in Pilsen, Charles University in Prague, Pilsen, Czech Republic.
authors.forename: J
authors.initials: J
authors.lastname: Bruha
authors.affiliation: Biomedical Centre, Faculty of Medicine in Pilsen, Charles University in Prague, Alej Svobody 76, 323 00, Pilsen, Czech Republic.|Deparment of Surgery, Faculty Hospital and Faculty of Medicine in Pilsen, Charles University in Prague, Pilsen, Czech Republic.
authors.forename: M
authors.initials: M
authors.lastname: Skala
authors.affiliation: Biomedical Centre, Faculty of Medicine in Pilsen, Charles University in Prague, Alej Svobody 76, 323 00, Pilsen, Czech Republic.|Deparment of Surgery, Faculty Hospital and Faculty of Medicine in Pilsen, Charles University in Prague, Pilsen, Czech Republic.
authors.forename: V
authors.initials: V
authors.lastname: Liska
authors.affiliation: Department of Pathology, Faculty Hospital and Faculty of Medicine in Pilsen, Charles University in Prague, Pilsen, Czech Republic.
authors.forename: O
authors.initials: O
authors.lastname: Daum
authors.affiliation: Biomedical Centre, Faculty of Medicine in Pilsen, Charles University in Prague, Alej Svobody 76, 323 00, Pilsen, Czech Republic. pavel.soucek@lfp.cuni.cz.
authors.forename: P
authors.initials: P
authors.lastname: Soucek
mesh_terms: D018528:ATP-Binding Cassette Transporters / Q000378:metabolism*; D000368:Aged; D000964:Antimetabolites, Antineoplastic / Q000627:therapeutic use*; D015179:Colorectal Neoplasms / Q000188:drug therapy* / Q000473:pathology; D018572:Disease-Free Survival; D005260:Female; D005472:Fluorouracil / Q000627:therapeutic use*; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D027425:ATP-Binding Cassette, Sub-Family C Proteins / Q000378:metabolism*; D009364:Neoplasm Recurrence, Local; D011379:Prognosis; D012189:Retrospective Studies; D015996:Survival Rate
chemical_list: D018528:ATP-Binding Cassette Transporters; D000964:Antimetabolites, Antineoplastic; D005472:Fluorouracil; D027425:ATP-Binding Cassette, Sub-Family C Proteins; C421142:ABCC10 protein, human; C435500:ABCC11 protein, human
keywords: Colorectal cancer; Immunohistochemistry; Prognosis; Protein