title: Ustekinumab Treatment and Improvement of Physical Function and Health-Related Quality of Life in Patients With Psoriatic Arthritis.
abstract: To examine the effects of ustekinumab on patient-reported outcomes (PROs) in PSUMMIT 1 and PSUMMIT 2 patients with active psoriatic arthritis (PsA) who were methotrexate (MTX) naive, MTX experienced, or anti-tumor necrosis factor (TNF) experienced.
  
  
  
  Patients in the phase 3, PSUMMIT 1 (n = 615) and PSUMMIT 2 (n = 312) studies randomly (1:1:1) received placebo, ustekinumab 45-mg, or ustekinumab 90-mg subcutaneous injections at weeks 0, 4, 16, 28, 40, and 52. The PROs (Health Assessment Questionnaire [HAQ] disability index [DI], Dermatology Life Quality Index [DLQI], 36-Item Short Form [SF-36] health survey physical (PCS) and mental component summary scores, patient assessments of pain and disease activity, and impact of disease on productivity) were assessed at weeks 0, 24, and 52. In these post hoc analyses, outcomes were compared between the ustekinumab and placebo groups for 3 mutually exclusive antecedent-exposure populations from the combined studies: MTX/anti-TNF naive (placebo, n = 56; 45 mg, n = 58; and 90 mg, n = 66), MTX experienced, biologic agent naive (placebo, n = 192; 45 mg, n = 190; and 90 mg, n = 185), and anti-TNF experienced with or without MTX (placebo, n = 62; 45 mg, n = 60; and 90 mg, n = 58).
  
  
  
  At week 24, mean improvements from baseline in HAQ DI, DLQI, and SF-36 PCS scores were significantly greater in both ustekinumab groups versus placebo across antecedent-exposure groups. Greater proportions of ustekinumab-treated than placebo-treated patients (all P < 0.05) had clinically meaningful improvements in HAQ DI (≥0.3), DLQI (≥5), and SF-36 (≥5) scores at week 24, irrespective of drug exposure. Improvements in pain, disease activity, and impact of disease on productivity were similar, and benefits were maintained through week 52.
  
  
  
  Significant improvements in PROs with ustekinumab versus placebo were observed in 3 antecedent-exposure populations of PsA patients, including those with prior MTX and anti-TNF use.
authors.affiliation: Memorial University, Newfoundland, Canada.
authors.forename: Proton
authors.initials: P
authors.lastname: Rahman
authors.affiliation: Hospital de la Santa Creu i Sant Pau, Universitat Autònoa de Barcelona, Barcelona, Spain.
authors.forename: Lluis
authors.initials: L
authors.lastname: Puig
authors.affiliation: Tufts University School of Medicine, Boston, Massachusetts.
authors.forename: Alice B
authors.initials: AB
authors.lastname: Gottlieb
authors.affiliation: University of California, San Diego.
authors.forename: Arthur
authors.initials: A
authors.lastname: Kavanaugh
authors.affiliation: University of Glasgow, Glasgow, Scotland.
authors.forename: Iain B
authors.initials: IB
authors.lastname: McInnes
authors.affiliation: University of Rochester, Rochester, New York.
authors.forename: Christopher
authors.initials: C
authors.lastname: Ritchlin
authors.affiliation: Janssen Research & Development, LLC, Spring House, Pennsylvania.
authors.forename: Shu
authors.initials: S
authors.lastname: Li
authors.affiliation: Janssen Research & Development, LLC, Spring House, Pennsylvania.
authors.forename: Yuhua
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Janssen Research & Development, LLC, Spring House, Pennsylvania.
authors.forename: Michael
authors.initials: M
authors.lastname: Song
authors.affiliation: Janssen Research & Development, LLC, Spring House, Pennsylvania.
authors.forename: Alan
authors.initials: A
authors.lastname: Mendelsohn
authors.affiliation: Janssen Global Services, LLC, Malvern, Pennsylvania.
authors.forename: Chenglong
authors.initials: C
authors.lastname: Han
mesh_terms: D000328:Adult; D015535:Arthritis, Psoriatic / Q000188:drug therapy* / Q000503:physiopathology / Q000523:psychology; D001685:Biological Factors / Q000008:administration & dosage*; D003879:Dermatologic Agents / Q000008:administration & dosage*; D004185:Disability Evaluation; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007279:Injections, Subcutaneous; D008297:Male; D008875:Middle Aged; D011788:Quality of Life; D012720:Severity of Illness Index; D016896:Treatment Outcome; D000069549:Ustekinumab / Q000008:administration & dosage*
chemical_list: D001685:Biological Factors; D003879:Dermatologic Agents; D000069549:Ustekinumab