title: Acidosis and Urinary Calcium Excretion: Insights from Genetic Disorders.
abstract: Metabolic acidosis is associated with increased urinary calcium excretion and related sequelae, including nephrocalcinosis and nephrolithiasis. The increased urinary calcium excretion induced by metabolic acidosis predominantly results from increased mobilization of calcium out of bone and inhibition of calcium transport processes within the renal tubule. The mechanisms whereby acid alters the integrity and stability of bone have been examined extensively in the published literature. Here, after briefly reviewing this literature, we consider the effects of acid on calcium transport in the renal tubule and then discuss why not all gene defects that cause renal tubular acidosis are associated with hypercalciuria and nephrocalcinosis.
authors.affiliation: Departments of Pediatrics and todd2@ualberta.ca.|Physiology, University of Alberta, Edmonton, Canada.
authors.forename: R Todd
authors.initials: RT
authors.lastname: Alexander
authors.affiliation: Physiology, University of Alberta, Edmonton, Canada.
authors.forename: Emmanuelle
authors.initials: E
authors.lastname: Cordat
authors.affiliation: Institut National de la Santé et de la Recherche Médicale U970, Paris Centre de Recherche Cardiovasculaire, Université Paris Descartes, Sorbonne Paris Cité, Paris, France.
authors.forename: Régine
authors.initials: R
authors.lastname: Chambrey
authors.affiliation: Department of Cardiovascular and Renal Research, Institute of Molecular Medicine, University of Southern Denmark, Odense, Demark; and.
authors.forename: Henrik
authors.initials: H
authors.lastname: Dimke
authors.affiliation: Institut National de la Santé et de la Recherche Médicale U970, Paris Centre de Recherche Cardiovasculaire, Université Paris Descartes, Sorbonne Paris Cité, Paris, France.|Department of Physiologie, Hôpital Européen Georges Pompidou, Assistance Publique Hôpitaux de Paris, Paris, France.
authors.forename: Dominique
authors.initials: D
authors.lastname: Eladari
mesh_terms: D000137:Acid-Base Imbalance / Q000150:complications / Q000209:etiology / Q000378:metabolism; D000138:Acidosis / Q000145:classification / Q000235:genetics* / Q000652:urine*; D001847:Bone Diseases / Q000209:etiology; D002118:Calcium / Q000378:metabolism / Q000652:urine*; D006801:Humans; D053565:Hypercalciuria / Q000209:etiology; D007684:Kidney Tubules / Q000378:metabolism; D009397:Nephrocalcinosis / Q000209:etiology
chemical_list: D002118:Calcium
keywords: calcium; chronic metabolic acidosis; hypercalciuria; renal tubular acidosis