title: A Patient with Giant Rippled-Pattern Sebaceoma in the Occipital Region.
abstract: A 72-year-old male visited a nearby hospital with a large tumor in his occipital region, which had existed since 20 years. Since malignant tumor was suspected, he was referred to our department. At the initial consultation, an elastic-hard, yellow-brown, sessile tumor, measuring 8 × 7 × 5 cm and with a flat surface, was observed in the occipital region. The tumor was resected and covered with artificial dermis. Histopathologically, the lesion was composed of basal-cell-like cells with nest formation in the dermis. A rippled pattern, or the single-line arrangement of tumor cells involving the stroma, was present. In addition, some tumor clusters revealed the differentiation to sebaceous glands, and these cells were positive for cytokeratin (AE1/AE3) and epithelial membrane antigen, which is consistent with the staining of sebaceous glands. On the contrary, tumor cells were negative for epithelial antigen (Ber-EP4), and Ki67 (MIB1) index was 5% or lower. Therefore, we diagnosed the tumor as rippled-pattern sebaceoma and not as basal cell carcinoma. Although this case was quite unique in its large size, immunostaining was useful for the definite diagnosis.
authors.affiliation: Department of Dermatology, Fujita Health University School of Medicine, Toyoake, Japan.
authors.forename: Masayuki
authors.initials: M
authors.lastname: Takahashi
authors.affiliation: Department of Dermatology, Fujita Health University School of Medicine, Toyoake, Japan.
authors.forename: Masaru
authors.initials: M
authors.lastname: Arima
authors.affiliation: Department of Dermatology, Fujita Health University School of Medicine, Toyoake, Japan.
authors.forename: Yohei
authors.initials: Y
authors.lastname: Iwata
authors.affiliation: Department of Dermatology, Kariya Toyota General Hospital, Kariya, Japan.
authors.forename: Kayoko
authors.initials: K
authors.lastname: Suzuki
authors.affiliation: Department of Diagnostic Pathology, Fujita Health University Banbuntane Houtokukai Hospital, Nagoya, Japan.
authors.forename: Yoshikazu
authors.initials: Y
authors.lastname: Mizoguchi
authors.affiliation: Department of Diagnostic Pathology, Fujita Health University School of Medicine, Toyoake, Japan.
authors.forename: Makoto
authors.initials: M
authors.lastname: Kuroda
authors.affiliation: Department of Dermatology, Fujita Health University School of Medicine, Toyoake, Japan.
authors.forename: Kayoko
authors.initials: K
authors.lastname: Matsunaga
keywords: Giant sebaceoma; Occipital region; Rippled pattern