title: An assessment of olfactory function in patients with laryngopharyngeal reflux disease.
abstract: CONCLUSIONS
  The results reported here indicate that there was a statistically significant difference in the olfactory functions of laryngopharyngeal reflux patients vs the healthy group. To the best of the authors' knowledge, this study is the first to evaluate the olfactory function of patients diagnosed with laryngopharyngeal reflux using an objective method, 24-h pH monitoring.
  
  
  OBJECTIVE
  The aim of this study was to investigate olfactory functions in laryngopharyngeal reflux (LPR) patients and compare the results with healthy controls.
  
  
  METHODS
  A total of 60 participants; 30 men and women with a diagnosis of laryngopharyngeal reflux and 30 healthy controls, were included in the study. Patients in the laryngopharyngeal reflux group were evaluated by the Reflux Symptom Index (RSI), Reflux Finding Scores (RFS), and finally 24-h pH monitoring to confirm the diagnosis of laryngopharyngeal reflux. The Sniffin' Sticks olfactory test results of the laryngopharyngeal reflux and control groups were compared, and the relationship between the study findings and the olfactory parameters were evaluated.
  
  
  RESULTS
  The odor threshold, odor discrimination, odor identification, and TDI scores of the laryngopharyngeal reflux group were significantly lower than those of the control group. Also there was a statistically significant negative correlation detected between the olfactory test and some symptom and finding scores.
authors.affiliation: a Department of Otolaryngology, Head and Neck Surgery , Istanbul Gaziosmanpasa Taksim Education and Research Hospital , Istanbul , Turkey.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Emre Dinc
authors.affiliation: b Department of Otolaryngology, Head and Neck Surgery , Izmir Bozyaka Education and Research Hospital , Izmir , Turkey.
authors.forename: Abdullah
authors.initials: A
authors.lastname: Dalgic
authors.affiliation: a Department of Otolaryngology, Head and Neck Surgery , Istanbul Gaziosmanpasa Taksim Education and Research Hospital , Istanbul , Turkey.
authors.forename: Mehmet Ozgur
authors.initials: MO
authors.lastname: Avincsal
authors.affiliation: a Department of Otolaryngology, Head and Neck Surgery , Istanbul Gaziosmanpasa Taksim Education and Research Hospital , Istanbul , Turkey.
authors.forename: Seckin
authors.initials: S
authors.lastname: Ulusoy
authors.affiliation: c Department of General Surgery , Istanbul Gaziosmanpasa Taksim Education and Research Hospital , Istanbul , Turkey.
authors.forename: Akgun
authors.initials: A
authors.lastname: Celik
authors.affiliation: a Department of Otolaryngology, Head and Neck Surgery , Istanbul Gaziosmanpasa Taksim Education and Research Hospital , Istanbul , Turkey.
authors.forename: Omer Necati
authors.initials: ON
authors.lastname: Develioglu
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D050782:Esophageal pH Monitoring; D005260:Female; D006801:Humans; D057045:Laryngopharyngeal Reflux / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012903:Smell
keywords: Laryngopharyngeal reflux; Sniffin’ Sticks; olfactory function; pH monitoring