title: Human Respiratory Syncytial Virus: An Introduction.
abstract: Human respiratory syncytial virus (RSV) is understood to be a significant human pathogen in infants, young children, and the elderly and the immunocompromised. Over the last decade many important mechanisms contributing to RSV infection, replication, and disease pathogenesis have been revealed; however, there is still insufficient knowledge which has in part hampered vaccine development. Considerable information is accumulating regarding how RSV proteins modulate molecular signaling and immune responses to infection. Understanding how RSV interacts with its host is crucial to facilitate the development of safe and effective vaccines and therapeutic treatments.In this chapter, we provide a brief introduction into RSV replication, pathogenesis, and host immune response, and summarize the state of RSV vaccine and antiviral compounds in clinical stages of development. This chapter frames features of this book and the molecular methods used for understanding RSV interaction with the host.
authors.affiliation: Department of Infectious Diseases, College of Veterinary Medicine, Animal Health Research Center, University of Georgia, 111 Carlton Street, Athens, GA, 30602, USA.
authors.forename: Patricia A
authors.initials: PA
authors.lastname: Jorquera
authors.affiliation: Department of Infectious Diseases, College of Veterinary Medicine, Animal Health Research Center, University of Georgia, 111 Carlton Street, Athens, GA, 30602, USA.
authors.forename: Lydia
authors.initials: L
authors.lastname: Anderson
authors.affiliation: Department of Infectious Diseases, College of Veterinary Medicine, Animal Health Research Center, University of Georgia, 111 Carlton Street, Athens, GA, 30602, USA. ratripp@uga.edu.
authors.forename: Ralph A
authors.initials: RA
authors.lastname: Tripp
mesh_terms: D000368:Aged; D002648:Child; D054884:Host-Pathogen Interactions; D006801:Humans; D007113:Immunity, Innate; D016867:Immunocompromised Host; D007223:Infant; D018357:Respiratory Syncytial Virus Infections / Q000276:immunology* / Q000628:therapy / Q000821:virology; D018113:Respiratory Syncytial Virus, Human / Q000472:pathogenicity / Q000502:physiology*; D015398:Signal Transduction; D014764:Viral Proteins / Q000276:immunology; D014765:Viral Vaccines / Q000627:therapeutic use; D014779:Virus Replication
chemical_list: D014764:Viral Proteins; D014765:Viral Vaccines
keywords: Adaptive immune response; Antiviral compounds; Innate immune response; RSV proteins; Respiratory syncytial virus; Vaccine