title: COMPARISON TACHOCOMB WITH SURGIWRAP, SURGICEL AND LYODURA IN EPIDURAL FIBROSIS: AN EXPERIMENTAL RAT MODEL.
abstract: OBJECTIVE
  We designed this study to evaluate the effect of TachoComb and to compare it with SurgiWrap, Surgicel, and Lyodura in an experimental rat model for epidural fibrosis (EF).
  
  
  METHODS
  This prospective and experimental rat model study was performed at Dicle University, School of Medicine, Department of Neurosurgery, in Diyarbakir, Turkey, between January 2005 and June 2005, using 50 Sprague Dawley rats (30 female and 20 male) with a mean weight of 290 g. The rats were divided into five groups: TachoComb, Surgicel, SurgiWrap, Lyodura, and control.
  
  
  RESULTS
  Eight weeks after laminectomy, the rats were killed and EF was evaluated. EF was statistically different between the groups. The lowest EF score was in the TachoComb group (F = 6.915, p < 0.001).
  
  
  CONCLUSIONS
  According to this study, TachoComb was found to be a more effective agent in decreasing EF than Surgicel, SurgiWrap, or Lyodura.
authors.forename: Huseyin
authors.initials: H
authors.lastname: Karasu
authors.forename: Işil
authors.initials: I
authors.lastname: Güzel
mesh_terms: D000818:Animals; D007611:Aprotinin / Q000494:pharmacology*; D002483:Cellulose, Oxidized / Q000494:pharmacology*; D003094:Collagen / Q000494:pharmacology*; D004195:Disease Models, Animal; D004338:Drug Combinations; D004824:Epidural Space / Q000473:pathology*; D005260:Female; D005340:Fibrinogen / Q000494:pharmacology*; D005355:Fibrosis / Q000209:etiology / Q000517:prevention & control*; D007796:Laminectomy / Q000009:adverse effects / Q000379:methods*; D008159:Lumbar Vertebrae; D008297:Male; D011446:Prospective Studies; D051381:Rats; D017207:Rats, Sprague-Dawley; D013917:Thrombin / Q000494:pharmacology*; D014421:Turkey
chemical_list: D002483:Cellulose, Oxidized; D004338:Drug Combinations; C032281:Lyodura; C093991:tachocomb; C013695:Surgicel; D005340:Fibrinogen; D003094:Collagen; D007611:Aprotinin; D013917:Thrombin