title: Design Some New Type-I c-met Inhibitors Based on Molecular Docking and Topomer CoMFA Research.
abstract: In this paper, a specific design strategy targeting c-met kinase was reported based on docking modeling and topomer comparative molecular field analysis (Topomer CoMFA). A novel U-shape conformation which is distinct from the literature was demonstrated by molecular docking among 68 U-shape c-met inhibitors. According to the docking results, two Topomer CoMFA models with high predictive ability were established based on the two fragment rule. The results from both docking and topomer CoMFA showed that the π-π stacking interaction with Tyr1230 and the hydrogen bond with hinge region play an important role in inhibitory activity. Furthermore, the flexible linker and the adjacent solvent group would be favorable to stabilize the conformation and to enhance the two interactions mentioned above. Based on our patent, 14 new compounds were designed by our design strategy. The binding mode exhibited as expected and their activities were predicted by topomer CoMFA model. The preliminary biological tests showed most of them have potent activity to c-met kinase. Our study would provide guidelines to design some new U-shaped c-met inhibitors with new scaffolds and optimize the current molecules.
authors.affiliation: School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, 510515, P. R. China.
authors.forename: Yuanxin
authors.initials: Y
authors.lastname: Tian
authors.affiliation: Guangdong Provincial Key Laboratory of Food Quality and Safety, South China Agricultural University, Guangzhou 510642, P. R. China.
authors.forename: Yudong
authors.initials: Y
authors.lastname: Shen
authors.affiliation: School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, 510515, P. R. China.
authors.forename: Xianzuo
authors.initials: X
authors.lastname: Zhang
authors.affiliation: School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, 510515, P. R. China.
authors.forename: Lianbao
authors.initials: L
authors.lastname: Ye
authors.affiliation: School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, 510515, P. R. China.
authors.forename: Zhonghuang
authors.initials: Z
authors.lastname: Li
authors.affiliation: Guangzhou Jinan Biomedicine Research and Development Center, Guangdong Provincial Key Laboratory of Bioengineering Medicine, Jinan University, Guangzhou, 510632, P. R. China.
authors.forename: Zhong
authors.initials: Z
authors.lastname: Liu
authors.affiliation: School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, 510515, P. R. China. zhangjj@smu.edu.cn.
authors.forename: Jiajie
authors.initials: J
authors.lastname: Zhang
authors.affiliation: School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, 510515, P. R. China. shuguang@smu.edu.cn.
authors.forename: Shuguang
authors.initials: S
authors.lastname: Wu
keywords: Docking; Drug design; Topomer CoMFA; c-met Inhibitors