title: [BRAIN NATRIURETIC PEPTIDE AS A MARKER OF SEVERITY OF PATIENT'S CONDITION AFTER SEVERE TRAUMATIC BRAIN INJURY].
abstract: The aim of the study was to assess the significance of NT-proBNP levels as a predictor of the severity of patients' condition after severe TBI and critical stress of the heart. In this prospective observational study 118 patients admitted on 1-4 day after severe TBI (GCS <8 points on admission) was supervised. The average age of patients was 32 +/- 16 years, 28 women and 90 men were in this group. 12 of the observed patients died within the first 10 days. NT-proBNP level was determined by immunochemiluminescent analyzer "Immulite 2000" (Siemens). Blood sampling was performed daily at 8:00 am during the acute period--an average for 7 days (5 to 10) from the date of admission. At the same time hemodynamic status was assessed by PiCCO. It has been shown that NT-proBNP level may be not only a marker of severity of condition and poor outcome in patients with severe TBI, but also can be used as a good predictor of exhaustion of compensatory myocardial capacity in these patients.
authors.forename: A A
authors.initials: AA
authors.lastname: Sychev
authors.forename: I A
authors.initials: IA
authors.lastname: Savin
authors.forename: A S
authors.initials: AS
authors.lastname: Goyachev
authors.forename: V D
authors.initials: VD
authors.lastname: Tenedieva
authors.forename: A V
authors.initials: AV
authors.lastname: Oshorov
authors.forename: A A
authors.initials: AA
authors.lastname: Polupan
authors.forename: A G
authors.initials: AG
authors.lastname: Gavrilov
authors.forename: A A
authors.initials: AA
authors.lastname: Potapov
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood*; D000070642:Brain Injuries, Traumatic / Q000097:blood* / Q000401:mortality / Q000503:physiopathology; D005260:Female; D006439:Hemodynamics; D006801:Humans; D008297:Male; D008875:Middle Aged; D020097:Natriuretic Peptide, Brain / Q000097:blood*; D011379:Prognosis
chemical_list: D015415:Biomarkers; D020097:Natriuretic Peptide, Brain