title: A Single-Institution Radical Surgery Results in Stage IB2/IIA2 (Bulky) Cervical Cancer.
abstract: The aim of this study is to evaluate the results of radical surgery in patients with stage IB2 to IIA2 cervical cancer who were operated on at our center between 2002 and 2015.
  
  
  
  Forty-seven cases of patients with stage IB2/IIA2 cervical cancer who underwent primary radical surgery between 2002 and 2015 were enrolled in this study. Patients' files and pathological reports were retrospectively reviewed. Surgical, pathological, and clinical variables were analyzed and their impact on survival period was researched. Disease-free survival and overall survival periods were determined using the Kaplan-Meier test. The P value was considered significant if less than 0.05.
  
  
  
  Type C2 radical hysterectomy with lymphadenectomy (5 pelvic, 42 pelvic and para-aortic) was performed for all of the 47 patients in accordance with the Querleu-Morrow classification. Thirty-three of the cases were stage Ib2 and 14 cases were IIa2. Five years of overall survival was 80%. Recurrence was noted in 10 (7 pelvic, 3 extrapelvic) patients. Adjuvant therapies were needed for 83% of the patients. A univariate analysis was made for all included variables in this research and, other than recurrence, none of them was found to be statistically significant on OS and DFS.
  
  
  
  Although adjuvant therapies are often resorted to, primary radical surgery is also a reasonable treatment option for stage IB2/IIA2 cervical cancer, especially in young premenopausal patients when preserving ovarian functions is desired.
authors.affiliation: *Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, Faculty of Medicine, Çukurova University, Adana; †Department of Obstetrics and Gynecology, Kirikkale Government Hospital, Kirikkale; and ‡Department of Biostatistic, Faculty of Medicine, and §Department of Pathology, Division of Gynecologic Pathology, Faculty of Medicine, Çukurova University, Adana, Turkey.
authors.forename: Ghanim
authors.initials: G
authors.lastname: Khatib
authors.forename: Ümran
authors.initials: Ü
authors.lastname: Küçükgöz Güleç
authors.forename: Ahmet
authors.initials: A
authors.lastname: Bariş Güzel
authors.forename: Berk
authors.initials: B
authors.lastname: Uygur
authors.forename: Gülşah
authors.initials: G
authors.lastname: Seydaoğlu
authors.forename: Derya
authors.initials: D
authors.lastname: Gümürdülü
authors.forename: Mehmet Ali
authors.initials: MA
authors.lastname: Vardar
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000473:pathology / Q000601:surgery; D005260:Female; D006801:Humans; D007044:Hysterectomy; D008197:Lymph Node Excision; D008198:Lymph Nodes / Q000473:pathology / Q000601:surgery; D008875:Middle Aged; D009367:Neoplasm Staging; D012189:Retrospective Studies; D016896:Treatment Outcome; D002583:Uterine Cervical Neoplasms / Q000473:pathology* / Q000601:surgery*