title: Lycopene Consumption and Risk of Colorectal Cancer: A Meta-Analysis of Observational Studies.
abstract: A number of epidemiological studies have explored the association between lycopene or lycopene-rich food intake and the risk of colorectal cancer, but the results of these studies have not been consistent. We conducted a systematic review and meta-analysis of studies published in the PubMed and EMBASE databases to quantitatively assess the association between lycopene consumption and the risk of colorectal cancer. A total of 15 studies were included in the meta-analysis, and the summary relative risk (RR) for highest versus lowest category indicated no significant association between lycopene consumption and the risk of colorectal cancer [RR = 0.94, 95% confidence interval (CI): 0.80-1.10]. However, a significant inverse association was observed between lycopene consumption and the site of cancer in the colon (RR = 0.88, 95% CI: 0.81-0.96). We also found that the incidence of colon cancer and lycopene intake did not exhibit dose-response relationships. The Grades of Recommendations Assessment, Development and Evaluation (GRADE) quality in our study was very low. In conclusion, this meta-analysis indicates that lycopene consumption is not associated with the risk of colorectal cancer. Further research will be needed in this area to provide conclusive evidence.
authors.affiliation: a Department of General Surgery , Xiangya Hospital of Central South University , Changsha , China.
authors.forename: Xin
authors.initials: X
authors.lastname: Wang
authors.affiliation: b Department of Physiology , Xiangya School of Medical Central South University , Changsha , China.
authors.forename: Hui-Hui
authors.initials: HH
authors.lastname: Yang
authors.affiliation: c Department of Psychology , The Second Artillery General Hospital, PLA . Beijing , China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Liu
authors.affiliation: d Department of Science and Education , The First People's Hospital of Changde City , Changde , China.
authors.forename: Quan
authors.initials: Q
authors.lastname: Zhou
authors.affiliation: e Department of General Surgery , Xiangya Hospital of Central South University , Changsha , China.
authors.forename: Zi-Hua
authors.initials: ZH
authors.lastname: Chen
mesh_terms: D016588:Anticarcinogenic Agents / Q000627:therapeutic use*; D000975:Antioxidants / Q000627:therapeutic use*; D002338:Carotenoids / Q000627:therapeutic use*; D016022:Case-Control Studies; D015331:Cohort Studies; D015179:Colorectal Neoplasms / Q000453:epidemiology / Q000517:prevention & control*; D000072001:Diet, Healthy; D019587:Dietary Supplements; D019317:Evidence-Based Medicine; D006801:Humans; D000077276:Lycopene; D064887:Observational Studies as Topic; D015203:Reproducibility of Results; D012306:Risk
chemical_list: D016588:Anticarcinogenic Agents; D000975:Antioxidants; D002338:Carotenoids; D000077276:Lycopene