title: Effects of Lactobacillus gasseri OLL2716 on Helicobacter pylori-Associated Dyspepsia: A Multicenter Randomized Double-Blind Controlled Trial.
abstract: Some Lactobacillus spp. suppress Helicobacter pylori in the stomach and have potential therapeutic applications for the treatment of gastrointestinal conditions. In this study, the effects of Lactobacillus strains on functional dyspepsia associated with H. pylori infection were examined. Volunteers were screened using the (13)C-urea breath test (UBT) and H. pylori stool test, and 131 participants who met the selection criteria (mean age: 48.9 years) were randomly given L. gasseri OLL2716-containing yogurt or placebo yogurt once daily for 12 weeks. Gastrointestinal symptoms (epigastric pain, bloating, postprandial fullness, nausea, and heartburn) and the levels of serum pepsinogen (PG), (13)C-UBT, and H. pylori stool antigen were assessed. No significant differences were observed between the groups in UBT results, H. pylori stool antigens, or the serum PGI/II ratio. In the L. gasseri group, postprandial fullness was significantly lower at the end of the trial compared to the initial level (p < 0.05) and significantly fewer patients had a VAS score of >10 for bloating compared to the placebo group (p < 0.05). Dietary supplementation with L. gasseri OLL2716-containing yogurt may effectively suppress dyspeptic symptoms in H. pylori-infected patients. This study was registered at the University Hospital Medical Network Clinical Trial Registry (UMIN000016746).
authors.affiliation: Department of Internal Medicine, Tokai University School of Medicine, Shimokasuya, Isehara, Kanagawa 259-1193, Japan.
authors.forename: Atsushi
authors.identifier: 0000-0003-0067-4008
authors.initials: A
authors.lastname: Takagi
authors.affiliation: Department of Internal Medicine, Tokai University School of Medicine, Shimokasuya, Isehara, Kanagawa 259-1193, Japan.
authors.forename: Hidetaka
authors.identifier: 0000-0002-1734-0840
authors.initials: H
authors.lastname: Yanagi
authors.affiliation: Department of Internal Medicine, Tokai University School of Medicine, Shimokasuya, Isehara, Kanagawa 259-1193, Japan.
authors.forename: Hideki
authors.initials: H
authors.lastname: Ozawa
authors.affiliation: Department of Gastroenterology, Kohnodai Hospital, National Center for Global Health and Medicine, 1-7-1 Kohnodai, Ichikawa, Chiba 272-8516, Japan.
authors.forename: Naomi
authors.initials: N
authors.lastname: Uemura
authors.affiliation: Department of Medicine, Social Insurance Shiga Hospital, 16-1 Fujimidai, Otsu, Shiga 520-0846, Japan.
authors.forename: Shigemi
authors.identifier: 0000-0003-1386-0985
authors.initials: S
authors.lastname: Nakajima
authors.affiliation: Department of General Medicine, Kawasaki Medical School, 577 Matsushima, Kurashiki, Okayama 701-0192, Japan.
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Inoue
authors.affiliation: Department of Endoscopy, Tokyo Medical College, 6-7-1 Nishishijuku, Tokyo 160-0023, Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Kawai
authors.affiliation: Research & Development Laboratories, Meiji Co. Ltd., 540 Naruta, Odawara, Kanagawa 250-0862, Japan.
authors.forename: Toshihiro
authors.initials: T
authors.lastname: Ohtsu
authors.affiliation: Division of Infectious Disease, Tokai University School of Medicine, Shimokasuya, Isehara, Kanagawa 259-1193, Japan.
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Koga