title: The new Asian modified CKD-EPI equation leads to more accurate GFR estimation in Chinese patients with CKD.
abstract: OBJECTIVE
  To verify whether the new Asian modified CKD-EPI equation improved the performance of original one in determining GFR in Chinese patients with CKD.
  
  
  METHODS
  A well-designed paired cohort was set up. Measured GFR (mGFR) was the result of99mTc-diethylene triamine pentaacetic acid (99mTc-DTPA) dual plasma sample clearance method. The estimated GFR (eGFR) was the result of the CKD-EPI equation (eGFR1) and the new Asian modified CKD-EPI equation (eGFR2). The comparisons were performed to evaluate the superiority of the eGFR2 in bias, accuracy, precision, concordance correlation coefficient and the slope of regression equation and measure agreement.
  
  
  RESULTS
  A total of 195 patients were enrolled and analyzed. The new Asian modified CKD-EPI equation improved the performance of the original one in bias and accuracy. However, nearly identical performance was observed in the respect of precision, concordance correlation coefficient, slope of eGFR against mGFR and 95 % limit of agreement. In the subgroup of GFR < 60 mL min-1/1.73 m2, the bias of eGFR1 was less than eGFR2 but they have comparable precision and accuracy. In the subgroup of GFR > 60 mL min-1/1.73 m2, eGFR2 performed better than eGFR1 in terms of bias and accuracy.
  
  
  CONCLUSIONS
  The new Asian modified CKD-EPI equation can lead to more accurate GFR estimation in Chinese patients with CKD in general practice, especially in the higher GFR group.
authors.affiliation: Department of Nephrology, Bethune International Peace Hospital, No. 398 of Zhongshan Western Road, Shijiazhuang, Hebei Province, People's Republic of China.
authors.forename: Jinghua
authors.initials: J
authors.lastname: Wang
authors.affiliation: Institute of Nuclear Medicine, The Third Hospital, Hebei Medical University, No. 139 Ziqiang Road, Qiaoxi District, Shijiazhuang, 050051, Hebei, People's Republic of China. woxinfly1982@126.com.
authors.forename: Peng
authors.initials: P
authors.lastname: Xie
authors.affiliation: Institute of Nuclear Medicine, The Third Hospital, Hebei Medical University, No. 139 Ziqiang Road, Qiaoxi District, Shijiazhuang, 050051, Hebei, People's Republic of China.
authors.forename: Jian-Min
authors.initials: JM
authors.lastname: Huang
authors.affiliation: Department of Research, The Third Hospital, Hebei Medical University, No. 139 Ziqiang Road, Qiaoxi District, Shijiazhuang, 050051, Hebei, People's Republic of China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Qu
authors.affiliation: Institute of Nuclear Medicine, The Third Hospital, Hebei Medical University, No. 139 Ziqiang Road, Qiaoxi District, Shijiazhuang, 050051, Hebei, People's Republic of China.
authors.forename: Fang
authors.initials: F
authors.lastname: Zhang
authors.affiliation: Institute of Nuclear Medicine, The Third Hospital, Hebei Medical University, No. 139 Ziqiang Road, Qiaoxi District, Shijiazhuang, 050051, Hebei, People's Republic of China.
authors.forename: Ling-Ge
authors.initials: LG
authors.lastname: Wei
authors.affiliation: Institute of Nuclear Medicine, The Third Hospital, Hebei Medical University, No. 139 Ziqiang Road, Qiaoxi District, Shijiazhuang, 050051, Hebei, People's Republic of China.
authors.forename: Peng
authors.initials: P
authors.lastname: Fu
authors.affiliation: Institute of Nuclear Medicine, The Third Hospital, Hebei Medical University, No. 139 Ziqiang Road, Qiaoxi District, Shijiazhuang, 050051, Hebei, People's Republic of China.
authors.forename: Xiao-Jie
authors.initials: XJ
authors.lastname: Huang
mesh_terms: D000328:Adult; D000368:Aged; D044466:Asian People / Q000706:statistics & numerical data; D015992:Body Mass Index; D002681:China / Q000453:epidemiology; D061827:Dimensional Measurement Accuracy; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D008297:Male; D016555:Matched-Pair Analysis; D008657:Metabolic Clearance Rate; D008875:Middle Aged; D019275:Radiopharmaceuticals / Q000493:pharmacokinetics; D065667:Renal Elimination; D051436:Renal Insufficiency, Chronic / Q000175:diagnosis / Q000208:ethnology / Q000503:physiopathology; D015203:Reproducibility of Results; D016284:Technetium Tc 99m Pentetate / Q000493:pharmacokinetics* / Q000494:pharmacology
chemical_list: D019275:Radiopharmaceuticals; D016284:Technetium Tc 99m Pentetate
keywords: CKD-EPI equation; Chronic kidney disease; Glomerular filtration rate