title: Metabolomics Profiling for Obstructive Sleep Apnea and Simple Snorers.
abstract: Few clinical studies have explored altered urinary metabolite levels in patients with obstructive sleep apnea (OSA). Thus, we applied a metabolomics approach to analyze urinary metabolites in three groups of participants: patients with polysomnography (PSG)-confirmed OSA, simple snorers (SS), and normal subjects. Ultra-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry and gas chromatography coupled with time-of-flight mass spectrometry were used. A total of 21 and 31 metabolites were differentially expressed in the SS and OSA groups, respectively. Patients with OSA had 18 metabolites different from those with SS. Of the 56 metabolites detected among the 3 groups, 24 were consistently higher or lower. A receiver operator curve analysis revealed that the combination of 4-hydroxypentenoic acid, arabinose, glycochenodeoxycholate-3-sulfate, isoleucine, serine, and xanthine produced a moderate diagnostic score with a sensitivity (specificity) of 75% (78%) for distinguishing OSA from those without OSA. The combination of 4-hydroxypentenoic acid, 5-dihydrotestosterone sulfate, serine, spermine, and xanthine distinguished OSA from SS with a sensitivity of 85% and specificity of 80%. Multiple metabolites and metabolic pathways associated with SS and OSA were identified using the metabolomics approach, and the altered metabolite signatures could potentially serve as an alternative diagnostic method to PSG.
authors.affiliation: Department of Otolaryngology Head and Neck Surgery &Center of Sleep Medicine, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Yishan Road 600, 200233 Shanghai, China.|Otolaryngological Institute of Shanghai Jiao Tong University, Yishan Road 600, 200233 Shanghai, China.|Clinical Research Center, Shanghai Jiao Tong University School of Medicine, South Chongqing Road 225, 200020 Shanghai, China.
authors.forename: Huajun
authors.initials: H
authors.lastname: Xu
authors.affiliation: Center for Translational Medicine, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Yishan Road 600, 200233 Shanghai, China.
authors.forename: Xiaojiao
authors.initials: X
authors.lastname: Zheng
authors.affiliation: Department of Otolaryngology Head and Neck Surgery &Center of Sleep Medicine, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Yishan Road 600, 200233 Shanghai, China.|Otolaryngological Institute of Shanghai Jiao Tong University, Yishan Road 600, 200233 Shanghai, China.|Clinical Research Center, Shanghai Jiao Tong University School of Medicine, South Chongqing Road 225, 200020 Shanghai, China.
authors.forename: Yingjun
authors.initials: Y
authors.lastname: Qian
authors.affiliation: Department of Otolaryngology Head and Neck Surgery &Center of Sleep Medicine, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Yishan Road 600, 200233 Shanghai, China.|Otolaryngological Institute of Shanghai Jiao Tong University, Yishan Road 600, 200233 Shanghai, China.|Clinical Research Center, Shanghai Jiao Tong University School of Medicine, South Chongqing Road 225, 200020 Shanghai, China.
authors.forename: Jian
authors.initials: J
authors.lastname: Guan
authors.affiliation: Department of Otolaryngology Head and Neck Surgery &Center of Sleep Medicine, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Yishan Road 600, 200233 Shanghai, China.|Otolaryngological Institute of Shanghai Jiao Tong University, Yishan Road 600, 200233 Shanghai, China.|Clinical Research Center, Shanghai Jiao Tong University School of Medicine, South Chongqing Road 225, 200020 Shanghai, China.
authors.forename: Hongliang
authors.initials: H
authors.lastname: Yi
authors.affiliation: Department of Otolaryngology Head and Neck Surgery &Center of Sleep Medicine, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Yishan Road 600, 200233 Shanghai, China.|Otolaryngological Institute of Shanghai Jiao Tong University, Yishan Road 600, 200233 Shanghai, China.|Clinical Research Center, Shanghai Jiao Tong University School of Medicine, South Chongqing Road 225, 200020 Shanghai, China.
authors.forename: Jianyin
authors.initials: J
authors.lastname: Zou
authors.affiliation: Department of Otolaryngology Head and Neck Surgery &Center of Sleep Medicine, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Yishan Road 600, 200233 Shanghai, China.|Otolaryngological Institute of Shanghai Jiao Tong University, Yishan Road 600, 200233 Shanghai, China.|Clinical Research Center, Shanghai Jiao Tong University School of Medicine, South Chongqing Road 225, 200020 Shanghai, China.
authors.forename: Yuyu
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Otolaryngology Head and Neck Surgery &Center of Sleep Medicine, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Yishan Road 600, 200233 Shanghai, China.|Otolaryngological Institute of Shanghai Jiao Tong University, Yishan Road 600, 200233 Shanghai, China.
authors.forename: Lili
authors.initials: L
authors.lastname: Meng
authors.affiliation: Center for Translational Medicine, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Yishan Road 600, 200233 Shanghai, China.
authors.forename: Aihua
authors.initials: A
authors.lastname: Zhao
authors.affiliation: Department of Otolaryngology Head and Neck Surgery &Center of Sleep Medicine, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Yishan Road 600, 200233 Shanghai, China.|Otolaryngological Institute of Shanghai Jiao Tong University, Yishan Road 600, 200233 Shanghai, China.|Clinical Research Center, Shanghai Jiao Tong University School of Medicine, South Chongqing Road 225, 200020 Shanghai, China.
authors.forename: Shankai
authors.initials: S
authors.lastname: Yin
authors.affiliation: Clinical Research Center, Shanghai Jiao Tong University School of Medicine, South Chongqing Road 225, 200020 Shanghai, China.|Center for Translational Medicine, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Yishan Road 600, 200233 Shanghai, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Jia
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood* / Q000652:urine*; D015992:Body Mass Index; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008297:Male; D055442:Metabolome; D055432:Metabolomics; D008875:Middle Aged; D012372:ROC Curve; D020181:Sleep Apnea, Obstructive / Q000378:metabolism*; D012913:Snoring / Q000378:metabolism*
chemical_list: D015415:Biomarkers