title: Advanced-Stage Nasopharyngeal Carcinoma: Restaging System after Neoadjuvant Chemotherapy on the Basis of MR Imaging Determines Survival.
abstract: Purpose To evaluate the prognostic value of the restaging system after neoadjuvant chemotherapy (NACT) in patients with advanced-stage nasopharyngeal carcinoma (NPC). Materials and Methods This study was approved by the clinical research committee and a written informed consent was required before enrolling in the study. Prospectively enrolled were 412 consecutive patients with stage III-IVb NPC treated with NACT followed by concurrent chemotherapy and radiation therapy. Patients were staged before NACT and restaged after NACT. The progression-free survival (PFS) and distant metastasis-free survival (DMFS) were calculated with the Kaplan-Meier method, and differences were compared by using the log-rank test. Results Post-NACT T classification (PFS, P = .001) and N classification (PFS, P < .001; DMFS, P = .001) resulted in better survival curve separations than pre-NACT T classification and N classification. Patients downstaged from N2-N3 to N0-N1 disease had a better prognosis than did patients who continued to have N2-N3 diseases (3-year PFS, 83.8% vs 66.6%, P = .001; 3-year DMFS, 88.0% vs 78.4%, P = .026). Multivariate analysis revealed that post-NACT T classification (hazard ratio [HR] = 1.67; 95% confidence interval [CI]: 1.18, 2.36; P = .003) and post-NACT N classification (HR = 1.54; 95% CI: 1.17, 2.03; P = .002) were independent prognostic factors for PFS; also, post-NACT N classification (HR = 1.48; 95% CI: 1.05, 2.07; P = .025) was an independent prognostic factor for DMFS. Multivariate analysis in patients with N2-N3 disease demonstrated that the N downstaging effects of NACT was the only independent prognostic factor for PFS (HR = 0.48; 95% CI: 0.29, 0.81; P = .006) and DMFS (HR = 0.52; 95% CI: 0.28, 0.97; P = .039). Conclusion The post-NACT stage is more representative of prognosis than the pre-NACT stage in advanced-stage NPC patients, which suggests that major clinical decisions should be based on the post-NACT stage.©RSNA, 2016 Online supplemental material is available for this article.
authors.affiliation: From the State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine (L.T.L., Q.Y.C., L.Q.T., L.Z., S.S.G., C.M.X., X.W.L., L.G., H.Y.M., M.Y.C., C.Z., X.G., K.J.C., C.N.Q., M.S.Z., J.X.B., M.H.H., J.Y.S., Y.S., J.M., H.Q.M.), Department of Nasopharyngeal Carcinoma (L.T.L., Q.Y.C., L.Q.T., L.Z., S.S.G., L.G., H.Y.M., M.Y.C., C.Z., X.G., K.J.C., C.N.Q., H.Q.M.), Imaging Diagnosis and Interventional Center (C.M.X., X.W.L.), Good Clinical Practice Center (M.H.H.), Department of Molecular Diagnostics (J.Y.S.), and Department of Radiation Oncology (Y.S., J.M.), Sun Yat-sen University Cancer Center, 651 Dongfeng Road East, Guangzhou 510060, P.R. China (H.Q.M.).
authors.forename: Li-Ting
authors.initials: LT
authors.lastname: Liu
authors.affiliation: From the State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine (L.T.L., Q.Y.C., L.Q.T., L.Z., S.S.G., C.M.X., X.W.L., L.G., H.Y.M., M.Y.C., C.Z., X.G., K.J.C., C.N.Q., M.S.Z., J.X.B., M.H.H., J.Y.S., Y.S., J.M., H.Q.M.), Department of Nasopharyngeal Carcinoma (L.T.L., Q.Y.C., L.Q.T., L.Z., S.S.G., L.G., H.Y.M., M.Y.C., C.Z., X.G., K.J.C., C.N.Q., H.Q.M.), Imaging Diagnosis and Interventional Center (C.M.X., X.W.L.), Good Clinical Practice Center (M.H.H.), Department of Molecular Diagnostics (J.Y.S.), and Department of Radiation Oncology (Y.S., J.M.), Sun Yat-sen University Cancer Center, 651 Dongfeng Road East, Guangzhou 510060, P.R. China (H.Q.M.).
authors.forename: Qiu-Yan
authors.initials: QY
authors.lastname: Chen
authors.affiliation: From the State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine (L.T.L., Q.Y.C., L.Q.T., L.Z., S.S.G., C.M.X., X.W.L., L.G., H.Y.M., M.Y.C., C.Z., X.G., K.J.C., C.N.Q., M.S.Z., J.X.B., M.H.H., J.Y.S., Y.S., J.M., H.Q.M.), Department of Nasopharyngeal Carcinoma (L.T.L., Q.Y.C., L.Q.T., L.Z., S.S.G., L.G., H.Y.M., M.Y.C., C.Z., X.G., K.J.C., C.N.Q., H.Q.M.), Imaging Diagnosis and Interventional Center (C.M.X., X.W.L.), Good Clinical Practice Center (M.H.H.), Department of Molecular Diagnostics (J.Y.S.), and Department of Radiation Oncology (Y.S., J.M.), Sun Yat-sen University Cancer Center, 651 Dongfeng Road East, Guangzhou 510060, P.R. China (H.Q.M.).
authors.forename: Lin-Quan
authors.initials: LQ
authors.lastname: Tang
authors.affiliation: From the State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine (L.T.L., Q.Y.C., L.Q.T., L.Z., S.S.G., C.M.X., X.W.L., L.G., H.Y.M., M.Y.C., C.Z., X.G., K.J.C., C.N.Q., M.S.Z., J.X.B., M.H.H., J.Y.S., Y.S., J.M., H.Q.M.), Department of Nasopharyngeal Carcinoma (L.T.L., Q.Y.C., L.Q.T., L.Z., S.S.G., L.G., H.Y.M., M.Y.C., C.Z., X.G., K.J.C., C.N.Q., H.Q.M.), Imaging Diagnosis and Interventional Center (C.M.X., X.W.L.), Good Clinical Practice Center (M.H.H.), Department of Molecular Diagnostics (J.Y.S.), and Department of Radiation Oncology (Y.S., J.M.), Sun Yat-sen University Cancer Center, 651 Dongfeng Road East, Guangzhou 510060, P.R. China (H.Q.M.).
authors.forename: Lu
authors.initials: L
authors.lastname: Zhang
authors.affiliation: From the State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine (L.T.L., Q.Y.C., L.Q.T., L.Z., S.S.G., C.M.X., X.W.L., L.G., H.Y.M., M.Y.C., C.Z., X.G., K.J.C., C.N.Q., M.S.Z., J.X.B., M.H.H., J.Y.S., Y.S., J.M., H.Q.M.), Department of Nasopharyngeal Carcinoma (L.T.L., Q.Y.C., L.Q.T., L.Z., S.S.G., L.G., H.Y.M., M.Y.C., C.Z., X.G., K.J.C., C.N.Q., H.Q.M.), Imaging Diagnosis and Interventional Center (C.M.X., X.W.L.), Good Clinical Practice Center (M.H.H.), Department of Molecular Diagnostics (J.Y.S.), and Department of Radiation Oncology (Y.S., J.M.), Sun Yat-sen University Cancer Center, 651 Dongfeng Road East, Guangzhou 510060, P.R. China (H.Q.M.).
authors.forename: Shan-Shan
authors.initials: SS
authors.lastname: Guo
authors.affiliation: From the State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine (L.T.L., Q.Y.C., L.Q.T., L.Z., S.S.G., C.M.X., X.W.L., L.G., H.Y.M., M.Y.C., C.Z., X.G., K.J.C., C.N.Q., M.S.Z., J.X.B., M.H.H., J.Y.S., Y.S., J.M., H.Q.M.), Department of Nasopharyngeal Carcinoma (L.T.L., Q.Y.C., L.Q.T., L.Z., S.S.G., L.G., H.Y.M., M.Y.C., C.Z., X.G., K.J.C., C.N.Q., H.Q.M.), Imaging Diagnosis and Interventional Center (C.M.X., X.W.L.), Good Clinical Practice Center (M.H.H.), Department of Molecular Diagnostics (J.Y.S.), and Department of Radiation Oncology (Y.S., J.M.), Sun Yat-sen University Cancer Center, 651 Dongfeng Road East, Guangzhou 510060, P.R. China (H.Q.M.).
authors.forename: Chuan-Miao
authors.initials: CM
authors.lastname: Xie
authors.affiliation: From the State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine (L.T.L., Q.Y.C., L.Q.T., L.Z., S.S.G., C.M.X., X.W.L., L.G., H.Y.M., M.Y.C., C.Z., X.G., K.J.C., C.N.Q., M.S.Z., J.X.B., M.H.H., J.Y.S., Y.S., J.M., H.Q.M.), Department of Nasopharyngeal Carcinoma (L.T.L., Q.Y.C., L.Q.T., L.Z., S.S.G., L.G., H.Y.M., M.Y.C., C.Z., X.G., K.J.C., C.N.Q., H.Q.M.), Imaging Diagnosis and Interventional Center (C.M.X., X.W.L.), Good Clinical Practice Center (M.H.H.), Department of Molecular Diagnostics (J.Y.S.), and Department of Radiation Oncology (Y.S., J.M.), Sun Yat-sen University Cancer Center, 651 Dongfeng Road East, Guangzhou 510060, P.R. China (H.Q.M.).
authors.forename: Xue-Wen
authors.initials: XW
authors.lastname: Liu
authors.affiliation: From the State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine (L.T.L., Q.Y.C., L.Q.T., L.Z., S.S.G., C.M.X., X.W.L., L.G., H.Y.M., M.Y.C., C.Z., X.G., K.J.C., C.N.Q., M.S.Z., J.X.B., M.H.H., J.Y.S., Y.S., J.M., H.Q.M.), Department of Nasopharyngeal Carcinoma (L.T.L., Q.Y.C., L.Q.T., L.Z., S.S.G., L.G., H.Y.M., M.Y.C., C.Z., X.G., K.J.C., C.N.Q., H.Q.M.), Imaging Diagnosis and Interventional Center (C.M.X., X.W.L.), Good Clinical Practice Center (M.H.H.), Department of Molecular Diagnostics (J.Y.S.), and Department of Radiation Oncology (Y.S., J.M.), Sun Yat-sen University Cancer Center, 651 Dongfeng Road East, Guangzhou 510060, P.R. China (H.Q.M.).
authors.forename: Ling
authors.initials: L
authors.lastname: Guo
authors.affiliation: From the State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine (L.T.L., Q.Y.C., L.Q.T., L.Z., S.S.G., C.M.X., X.W.L., L.G., H.Y.M., M.Y.C., C.Z., X.G., K.J.C., C.N.Q., M.S.Z., J.X.B., M.H.H., J.Y.S., Y.S., J.M., H.Q.M.), Department of Nasopharyngeal Carcinoma (L.T.L., Q.Y.C., L.Q.T., L.Z., S.S.G., L.G., H.Y.M., M.Y.C., C.Z., X.G., K.J.C., C.N.Q., H.Q.M.), Imaging Diagnosis and Interventional Center (C.M.X., X.W.L.), Good Clinical Practice Center (M.H.H.), Department of Molecular Diagnostics (J.Y.S.), and Department of Radiation Oncology (Y.S., J.M.), Sun Yat-sen University Cancer Center, 651 Dongfeng Road East, Guangzhou 510060, P.R. China (H.Q.M.).
authors.forename: Hao-Yuan
authors.initials: HY
authors.lastname: Mo
authors.affiliation: From the State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine (L.T.L., Q.Y.C., L.Q.T., L.Z., S.S.G., C.M.X., X.W.L., L.G., H.Y.M., M.Y.C., C.Z., X.G., K.J.C., C.N.Q., M.S.Z., J.X.B., M.H.H., J.Y.S., Y.S., J.M., H.Q.M.), Department of Nasopharyngeal Carcinoma (L.T.L., Q.Y.C., L.Q.T., L.Z., S.S.G., L.G., H.Y.M., M.Y.C., C.Z., X.G., K.J.C., C.N.Q., H.Q.M.), Imaging Diagnosis and Interventional Center (C.M.X., X.W.L.), Good Clinical Practice Center (M.H.H.), Department of Molecular Diagnostics (J.Y.S.), and Department of Radiation Oncology (Y.S., J.M.), Sun Yat-sen University Cancer Center, 651 Dongfeng Road East, Guangzhou 510060, P.R. China (H.Q.M.).
authors.forename: Ming-Yuan
authors.initials: MY
authors.lastname: Chen
authors.affiliation: From the State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine (L.T.L., Q.Y.C., L.Q.T., L.Z., S.S.G., C.M.X., X.W.L., L.G., H.Y.M., M.Y.C., C.Z., X.G., K.J.C., C.N.Q., M.S.Z., J.X.B., M.H.H., J.Y.S., Y.S., J.M., H.Q.M.), Department of Nasopharyngeal Carcinoma (L.T.L., Q.Y.C., L.Q.T., L.Z., S.S.G., L.G., H.Y.M., M.Y.C., C.Z., X.G., K.J.C., C.N.Q., H.Q.M.), Imaging Diagnosis and Interventional Center (C.M.X., X.W.L.), Good Clinical Practice Center (M.H.H.), Department of Molecular Diagnostics (J.Y.S.), and Department of Radiation Oncology (Y.S., J.M.), Sun Yat-sen University Cancer Center, 651 Dongfeng Road East, Guangzhou 510060, P.R. China (H.Q.M.).
authors.forename: Chong
authors.initials: C
authors.lastname: Zhao
authors.affiliation: From the State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine (L.T.L., Q.Y.C., L.Q.T., L.Z., S.S.G., C.M.X., X.W.L., L.G., H.Y.M., M.Y.C., C.Z., X.G., K.J.C., C.N.Q., M.S.Z., J.X.B., M.H.H., J.Y.S., Y.S., J.M., H.Q.M.), Department of Nasopharyngeal Carcinoma (L.T.L., Q.Y.C., L.Q.T., L.Z., S.S.G., L.G., H.Y.M., M.Y.C., C.Z., X.G., K.J.C., C.N.Q., H.Q.M.), Imaging Diagnosis and Interventional Center (C.M.X., X.W.L.), Good Clinical Practice Center (M.H.H.), Department of Molecular Diagnostics (J.Y.S.), and Department of Radiation Oncology (Y.S., J.M.), Sun Yat-sen University Cancer Center, 651 Dongfeng Road East, Guangzhou 510060, P.R. China (H.Q.M.).
authors.forename: Xiang
authors.initials: X
authors.lastname: Guo
authors.affiliation: From the State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine (L.T.L., Q.Y.C., L.Q.T., L.Z., S.S.G., C.M.X., X.W.L., L.G., H.Y.M., M.Y.C., C.Z., X.G., K.J.C., C.N.Q., M.S.Z., J.X.B., M.H.H., J.Y.S., Y.S., J.M., H.Q.M.), Department of Nasopharyngeal Carcinoma (L.T.L., Q.Y.C., L.Q.T., L.Z., S.S.G., L.G., H.Y.M., M.Y.C., C.Z., X.G., K.J.C., C.N.Q., H.Q.M.), Imaging Diagnosis and Interventional Center (C.M.X., X.W.L.), Good Clinical Practice Center (M.H.H.), Department of Molecular Diagnostics (J.Y.S.), and Department of Radiation Oncology (Y.S., J.M.), Sun Yat-sen University Cancer Center, 651 Dongfeng Road East, Guangzhou 510060, P.R. China (H.Q.M.).
authors.forename: Ka-Jia
authors.initials: KJ
authors.lastname: Cao
authors.affiliation: From the State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine (L.T.L., Q.Y.C., L.Q.T., L.Z., S.S.G., C.M.X., X.W.L., L.G., H.Y.M., M.Y.C., C.Z., X.G., K.J.C., C.N.Q., M.S.Z., J.X.B., M.H.H., J.Y.S., Y.S., J.M., H.Q.M.), Department of Nasopharyngeal Carcinoma (L.T.L., Q.Y.C., L.Q.T., L.Z., S.S.G., L.G., H.Y.M., M.Y.C., C.Z., X.G., K.J.C., C.N.Q., H.Q.M.), Imaging Diagnosis and Interventional Center (C.M.X., X.W.L.), Good Clinical Practice Center (M.H.H.), Department of Molecular Diagnostics (J.Y.S.), and Department of Radiation Oncology (Y.S., J.M.), Sun Yat-sen University Cancer Center, 651 Dongfeng Road East, Guangzhou 510060, P.R. China (H.Q.M.).
authors.forename: Chao-Nan
authors.initials: CN
authors.lastname: Qian
authors.affiliation: From the State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine (L.T.L., Q.Y.C., L.Q.T., L.Z., S.S.G., C.M.X., X.W.L., L.G., H.Y.M., M.Y.C., C.Z., X.G., K.J.C., C.N.Q., M.S.Z., J.X.B., M.H.H., J.Y.S., Y.S., J.M., H.Q.M.), Department of Nasopharyngeal Carcinoma (L.T.L., Q.Y.C., L.Q.T., L.Z., S.S.G., L.G., H.Y.M., M.Y.C., C.Z., X.G., K.J.C., C.N.Q., H.Q.M.), Imaging Diagnosis and Interventional Center (C.M.X., X.W.L.), Good Clinical Practice Center (M.H.H.), Department of Molecular Diagnostics (J.Y.S.), and Department of Radiation Oncology (Y.S., J.M.), Sun Yat-sen University Cancer Center, 651 Dongfeng Road East, Guangzhou 510060, P.R. China (H.Q.M.).
authors.forename: Mu-Sheng
authors.initials: MS
authors.lastname: Zeng
authors.affiliation: From the State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine (L.T.L., Q.Y.C., L.Q.T., L.Z., S.S.G., C.M.X., X.W.L., L.G., H.Y.M., M.Y.C., C.Z., X.G., K.J.C., C.N.Q., M.S.Z., J.X.B., M.H.H., J.Y.S., Y.S., J.M., H.Q.M.), Department of Nasopharyngeal Carcinoma (L.T.L., Q.Y.C., L.Q.T., L.Z., S.S.G., L.G., H.Y.M., M.Y.C., C.Z., X.G., K.J.C., C.N.Q., H.Q.M.), Imaging Diagnosis and Interventional Center (C.M.X., X.W.L.), Good Clinical Practice Center (M.H.H.), Department of Molecular Diagnostics (J.Y.S.), and Department of Radiation Oncology (Y.S., J.M.), Sun Yat-sen University Cancer Center, 651 Dongfeng Road East, Guangzhou 510060, P.R. China (H.Q.M.).
authors.forename: Jin-Xin
authors.initials: JX
authors.lastname: Bei
authors.affiliation: From the State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine (L.T.L., Q.Y.C., L.Q.T., L.Z., S.S.G., C.M.X., X.W.L., L.G., H.Y.M., M.Y.C., C.Z., X.G., K.J.C., C.N.Q., M.S.Z., J.X.B., M.H.H., J.Y.S., Y.S., J.M., H.Q.M.), Department of Nasopharyngeal Carcinoma (L.T.L., Q.Y.C., L.Q.T., L.Z., S.S.G., L.G., H.Y.M., M.Y.C., C.Z., X.G., K.J.C., C.N.Q., H.Q.M.), Imaging Diagnosis and Interventional Center (C.M.X., X.W.L.), Good Clinical Practice Center (M.H.H.), Department of Molecular Diagnostics (J.Y.S.), and Department of Radiation Oncology (Y.S., J.M.), Sun Yat-sen University Cancer Center, 651 Dongfeng Road East, Guangzhou 510060, P.R. China (H.Q.M.).
authors.forename: Ming-Huang
authors.initials: MH
authors.lastname: Hong
authors.affiliation: From the State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine (L.T.L., Q.Y.C., L.Q.T., L.Z., S.S.G., C.M.X., X.W.L., L.G., H.Y.M., M.Y.C., C.Z., X.G., K.J.C., C.N.Q., M.S.Z., J.X.B., M.H.H., J.Y.S., Y.S., J.M., H.Q.M.), Department of Nasopharyngeal Carcinoma (L.T.L., Q.Y.C., L.Q.T., L.Z., S.S.G., L.G., H.Y.M., M.Y.C., C.Z., X.G., K.J.C., C.N.Q., H.Q.M.), Imaging Diagnosis and Interventional Center (C.M.X., X.W.L.), Good Clinical Practice Center (M.H.H.), Department of Molecular Diagnostics (J.Y.S.), and Department of Radiation Oncology (Y.S., J.M.), Sun Yat-sen University Cancer Center, 651 Dongfeng Road East, Guangzhou 510060, P.R. China (H.Q.M.).
authors.forename: Jian-Yong
authors.initials: JY
authors.lastname: Shao
authors.affiliation: From the State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine (L.T.L., Q.Y.C., L.Q.T., L.Z., S.S.G., C.M.X., X.W.L., L.G., H.Y.M., M.Y.C., C.Z., X.G., K.J.C., C.N.Q., M.S.Z., J.X.B., M.H.H., J.Y.S., Y.S., J.M., H.Q.M.), Department of Nasopharyngeal Carcinoma (L.T.L., Q.Y.C., L.Q.T., L.Z., S.S.G., L.G., H.Y.M., M.Y.C., C.Z., X.G., K.J.C., C.N.Q., H.Q.M.), Imaging Diagnosis and Interventional Center (C.M.X., X.W.L.), Good Clinical Practice Center (M.H.H.), Department of Molecular Diagnostics (J.Y.S.), and Department of Radiation Oncology (Y.S., J.M.), Sun Yat-sen University Cancer Center, 651 Dongfeng Road East, Guangzhou 510060, P.R. China (H.Q.M.).
authors.forename: Ying
authors.initials: Y
authors.lastname: Sun
authors.affiliation: From the State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine (L.T.L., Q.Y.C., L.Q.T., L.Z., S.S.G., C.M.X., X.W.L., L.G., H.Y.M., M.Y.C., C.Z., X.G., K.J.C., C.N.Q., M.S.Z., J.X.B., M.H.H., J.Y.S., Y.S., J.M., H.Q.M.), Department of Nasopharyngeal Carcinoma (L.T.L., Q.Y.C., L.Q.T., L.Z., S.S.G., L.G., H.Y.M., M.Y.C., C.Z., X.G., K.J.C., C.N.Q., H.Q.M.), Imaging Diagnosis and Interventional Center (C.M.X., X.W.L.), Good Clinical Practice Center (M.H.H.), Department of Molecular Diagnostics (J.Y.S.), and Department of Radiation Oncology (Y.S., J.M.), Sun Yat-sen University Cancer Center, 651 Dongfeng Road East, Guangzhou 510060, P.R. China (H.Q.M.).
authors.forename: Jun
authors.initials: J
authors.lastname: Ma
authors.affiliation: From the State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine (L.T.L., Q.Y.C., L.Q.T., L.Z., S.S.G., C.M.X., X.W.L., L.G., H.Y.M., M.Y.C., C.Z., X.G., K.J.C., C.N.Q., M.S.Z., J.X.B., M.H.H., J.Y.S., Y.S., J.M., H.Q.M.), Department of Nasopharyngeal Carcinoma (L.T.L., Q.Y.C., L.Q.T., L.Z., S.S.G., L.G., H.Y.M., M.Y.C., C.Z., X.G., K.J.C., C.N.Q., H.Q.M.), Imaging Diagnosis and Interventional Center (C.M.X., X.W.L.), Good Clinical Practice Center (M.H.H.), Department of Molecular Diagnostics (J.Y.S.), and Department of Radiation Oncology (Y.S., J.M.), Sun Yat-sen University Cancer Center, 651 Dongfeng Road East, Guangzhou 510060, P.R. China (H.Q.M.).
authors.forename: Hai-Qiang
authors.initials: HQ
authors.lastname: Mai
mesh_terms: D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D014408:Biomarkers, Tumor / Q000032:analysis; D002277:Carcinoma; D017024:Chemotherapy, Adjuvant; D002945:Cisplatin / Q000008:administration & dosage; D000077143:Docetaxel; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D000077274:Nasopharyngeal Carcinoma; D009303:Nasopharyngeal Neoplasms / Q000188:drug therapy* / Q000473:pathology* / Q000532:radiotherapy; D020360:Neoadjuvant Therapy; D009367:Neoplasm Staging; D011379:Prognosis; D011446:Prospective Studies; D050397:Radiotherapy, Intensity-Modulated; D015996:Survival Rate; D043823:Taxoids; D016896:Treatment Outcome
chemical_list: D014408:Biomarkers, Tumor; D043823:Taxoids; D000077143:Docetaxel; D002945:Cisplatin; D005472:Fluorouracil