title: Assessing the effects of 35 European-derived BMI-associated SNPs in Mexican children.
abstract: The prevalence of obesity in Mexico has increased at an alarming rate in both adults and children. This study was undertaken to test in Mexican children the effects of single nucleotide polymorphisms (SNP) that have been associated with body mass index (BMI) and obesity in Europeans.
  
  
  
  School-age children (N = 1,559, 5-17 years) were recruited in Mexico City. Thirty-five SNPs with established effects on BMI and obesity were genotyped and analyzed individually and as a combined gene score (GS).
  
  
  
  SNPs in FAIM2 (rs7138803), GPRC5BB (rs12444979), MTIF3 (rs4771122), TFAP2B (rs987237), TMEM18 (rs7561317), and the GS were significantly associated with BMI. The GS explained 0.9% of the variance of BMI. Also, SNPs in LRRN6C (rs10968576) and MC4R (rs17782313) were significantly associated with overweight and obesity categories, respectively. Importantly, the effect allele frequency of 26/35 SNPs (74.3%) differed significantly between Mexican children and European adults. No significant gene × environment or gene × gene interactions were detected after Bonferroni adjustment.
  
  
  
  Several SNPs first associated with BMI/obesity in European adults replicated well in Mexican children, and investigating differences in the distribution of effect alleles across ethnic populations may shed light on genetic susceptibilities of different populations to obesity.
authors.affiliation: Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada.
authors.forename: Arkan
authors.initials: A
authors.lastname: Abadi
authors.affiliation: Medical Research Unit in Biochemistry, Hospital de Especialidades, Centro Médico Nacional Siglo XXI del Instituto Mexicano del Seguro Social, Mexico City, Mexico.
authors.forename: Jesus
authors.initials: J
authors.lastname: Peralta-Romero
authors.affiliation: Medical Research Unit in Biochemistry, Hospital de Especialidades, Centro Médico Nacional Siglo XXI del Instituto Mexicano del Seguro Social, Mexico City, Mexico.
authors.forename: Fernando
authors.initials: F
authors.lastname: Suarez
authors.affiliation: Medical Research Unit in Biochemistry, Hospital de Especialidades, Centro Médico Nacional Siglo XXI del Instituto Mexicano del Seguro Social, Mexico City, Mexico.
authors.forename: Jaime
authors.initials: J
authors.lastname: Gomez-Zamudio
authors.affiliation: Centro de investigación sobre enfermedades infecciosas, Instituto Nacional de Salud Pública, Cuernavaca, Morelos, Mexico.
authors.forename: Ana I
authors.initials: AI
authors.lastname: Burguete-Garcia
authors.affiliation: Medical Research Unit in Biochemistry, Hospital de Especialidades, Centro Médico Nacional Siglo XXI del Instituto Mexicano del Seguro Social, Mexico City, Mexico.
authors.forename: Miguel
authors.initials: M
authors.lastname: Cruz
authors.affiliation: Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada.|Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada.
authors.forename: David
authors.initials: D
authors.lastname: Meyre
mesh_terms: D000293:Adolescent; D015992:Body Mass Index; D002648:Child; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D005838:Genotype; D006801:Humans; D008297:Male; D008800:Mexico / Q000453:epidemiology; D009765:Obesity / Q000235:genetics; D050177:Overweight / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D044465:White People / Q000235:genetics