title: Long-term prognostic significance of pentraxin-3 in patients with acute myocardial infarction: 5-year prospective cohort study.
abstract: OBJECTIVE
  A predictive role of serum Pentraxin 3 (PTX3) for short-term adverse cardiovascular events including mortality in acute myocardial infarction (AMI) was reported in recent studies. The aim of the study was to investigate long-term prognostic significance of serum PTX3 in an AMI with 5-year follow-up period in this study.
  
  
  METHODS
  In this prospective study, 140 patients, who were admitted to the emergency department between January 2011 and December 2011 with acute chest pain and/or dyspnea and diagnosed with AMI and 60 healthy controls were included. PTX3 levels were measured at admission by using an ELISA method. The study group was divided into tertiles on the basis of admission PTX3 values: the high-PTX3 group (≥4.27 ng/mL), the middle-PTX3 groups (4.27-1.63 ng/mL), and the low-PTX3 group (≤1.63 ng/mL).
  
  
  RESULTS
  PTX3 level was significantly more greatly increased in the AMI group than in the controls (2.27±0.81 vs. 0.86±0.50 ng/mL, p<0.001). PTX3 level was found to be significantly positively correlated with TIMI score (r=0.368, p=0.037), high sensitive C-reactive protein (hsCRP) (r=0.452, p=0.024), pro-BNP (r=0.386, p=0.029), troponin I (r=0.417, p=<0.001), and GRACE score (r=0.355, p=0.045), and negatively correlated with HDL cholesterol (r=-0.203, p=0.016) and LVEF (r=-0.345, p=0.028). In multivariate analysis, PTX3 (OR=1.12, 95% CI 1.04-1.20; p=0.001) was a significant independent predictor of long-term cardiovascular mortality, after adjusting for other risk factors.
  
  
  CONCLUSIONS
  PTX3 is a novel biomarker that may help to identify high risk individuals with AMI, who are potentially at risk of early major adverse cardiovascular events including mortality in the long-term period.
authors.affiliation: Department of Cardiology, Faculty of Medicine, Trakya University; Edirne-Turkey. svtaltay@gmail.com.
authors.forename: Servet
authors.initials: S
authors.lastname: Altay
authors.affiliation: Department of Cardiology, Mustafa Kemalpaşa State Hospital; Bursa-Turkey.
authors.forename: Hüseyin Altuğ
authors.initials: HA
authors.lastname: Çakmak
authors.affiliation: Department of Cardiology, Siyami Ersek Thoracic and Cardiovascular Surgery Training and Research Hospital; İstanbul-Turkey.
authors.forename: Tuğba
authors.initials: T
authors.lastname: Kemaloğlu Öz
authors.affiliation: Department of Cardiology, Siyami Ersek Thoracic and Cardiovascular Surgery Training and Research Hospital; İstanbul-Turkey.
authors.forename: Fatma
authors.initials: F
authors.lastname: Özpamuk Karadeniz
authors.affiliation: Department of Cardiology, Faculty of Medicine, Yeditepe University; İstanbul-Turkey.
authors.forename: Ayça
authors.initials: A
authors.lastname: Türer
authors.affiliation: Department of Cardiology, Siyami Ersek Thoracic and Cardiovascular Surgery Training and Research Hospital; İstanbul-Turkey.
authors.forename: Hatice Betül
authors.initials: HB
authors.lastname: Erer
authors.affiliation: Department of Biochemistry, Siyami Ersek Thoracic and Cardiovascular Surgery Training and Research Hospital; İstanbul-Turkey.
authors.forename: Gülen Feyzan
authors.initials: GF
authors.lastname: Kılıç
authors.affiliation: Department of Cardiology, Cerrahpaşa Faculty of Medicine, İstanbul University, İstanbul; Ankara-Turkey.
authors.forename: İbrahim
authors.initials: İ
authors.lastname: Keleş
authors.affiliation: Department of Public Health, Cerrahpaşa Faculty of Medicine, İstanbul University, İstanbul; Ankara-Turkey.
authors.forename: Günay
authors.initials: G
authors.lastname: Can
authors.affiliation: Department of Cardiology, Siyami Ersek Thoracic and Cardiovascular Surgery Training and Research Hospital; İstanbul-Turkey.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Eren
mesh_terms: D015415:Biomarkers / Q000097:blood*; D002097:C-Reactive Protein / Q000378:metabolism*; D015331:Cohort Studies; D005260:Female; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009203:Myocardial Infarction / Q000097:blood / Q000401:mortality*; D011237:Predictive Value of Tests; D011446:Prospective Studies; D012307:Risk Factors; D000683:Serum Amyloid P-Component / Q000378:metabolism*; D016019:Survival Analysis; D014421:Turkey; D000099153:Pentraxins
chemical_list: D015415:Biomarkers; D002097:C-Reactive Protein; D000683:Serum Amyloid P-Component; D000099153:Pentraxins