title: Identification of 15 genetic loci associated with risk of major depression in individuals of European descent.
abstract: Despite strong evidence supporting the heritability of major depressive disorder (MDD), previous genome-wide studies were unable to identify risk loci among individuals of European descent. We used self-report data from 75,607 individuals reporting clinical diagnosis of depression and 231,747 individuals reporting no history of depression through 23andMe and carried out meta-analysis of these results with published MDD genome-wide association study results. We identified five independent variants from four regions associated with self-report of clinical diagnosis or treatment for depression. Loci with a P value <1.0 × 10(-5) in the meta-analysis were further analyzed in a replication data set (45,773 cases and 106,354 controls) from 23andMe. A total of 17 independent SNPs from 15 regions reached genome-wide significance after joint analysis over all three data sets. Some of these loci were also implicated in genome-wide association studies of related psychiatric traits. These studies provide evidence for large-scale consumer genomic data as a powerful and efficient complement to data collected from traditional means of ascertainment for neuropsychiatric disease genomics.
authors.affiliation: Statistics, Pfizer Global Research and Development, Pfizer, Inc., Cambridge, Massachusetts, USA.
authors.forename: Craig L
authors.initials: CL
authors.lastname: Hyde
authors.affiliation: Human Genetics and Computational Biomedicine, Pfizer Global Research and Development, Pfizer, Inc., Cambridge, Massachusetts, USA.
authors.forename: Michael W
authors.initials: MW
authors.lastname: Nagle
authors.affiliation: 23andMe, Inc., Mountain View, California, USA.
authors.forename: Chao
authors.initials: C
authors.lastname: Tian
authors.affiliation: Statistics, Pfizer Global Research and Development, Pfizer, Inc., Cambridge, Massachusetts, USA.
authors.forename: Xing
authors.initials: X
authors.lastname: Chen
authors.affiliation: Human Genetics and Computational Biomedicine, Pfizer Global Research and Development, Pfizer, Inc., Cambridge, Massachusetts, USA.
authors.forename: Sara A
authors.initials: SA
authors.lastname: Paciga
authors.affiliation: Human Genetics and Computational Biomedicine, Pfizer Global Research and Development, Pfizer, Inc., Cambridge, Massachusetts, USA.
authors.forename: Jens R
authors.identifier: 0000-0001-5106-5013
authors.initials: JR
authors.lastname: Wendland
authors.affiliation: 23andMe, Inc., Mountain View, California, USA.
authors.forename: Joyce Y
authors.initials: JY
authors.lastname: Tung
authors.affiliation: 23andMe, Inc., Mountain View, California, USA.
authors.forename: David A
authors.initials: DA
authors.lastname: Hinds
authors.affiliation: Center for Experimental Drugs and Diagnostics, Center for Human Genetic Research and Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts, USA.
authors.forename: Roy H
authors.initials: RH
authors.lastname: Perlis
authors.affiliation: Human Genetics and Computational Biomedicine, Pfizer Global Research and Development, Pfizer, Inc., Cambridge, Massachusetts, USA.
authors.forename: Ashley R
authors.identifier: 0000-0003-1265-5023
authors.initials: AR
authors.lastname: Winslow
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D003865:Major Depressive Disorder / Q000235:genetics*; D005260:Female; D056426:Genetic Loci / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D005838:Genotype; D006801:Humans; D008297:Male; D015201:Meta-Analysis as Topic; D008875:Middle Aged; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D012307:Risk Factors; D044465:White People / Q000235:genetics*