title: Targeting the interaction of Aurora kinases and SIRT1 mediated by Wnt signaling pathway in colorectal cancer: A critical review.
abstract: The Aurora kinases belong to the family of serine/threonine kinase, a central regulator of mitosis and their expression increased during G2/M phase. It is classified into Aurora A, B and C, each has distinct roles in cellular processes, which includes regulation of spindle assembly, function of centrosomes, cytoskeleton and cytokinesis. During cancer growth, their rapid increase makes most attractive marker for cancer treatment at present. However Aurora A kinase is known to be a marker for cancer therapy, the most important serine/threonine kinase of Aurora B kinase involvement in cancer is still inadequate. Subsequently, the recent findings revealed that the class III histone deacetylase of SIRT1 is a key regulator to activate Aurora kinases from S phase damaged DNA through Wnt signaling pathway. Even if both Aurora A kinase and SIRT1 serve as a marker for cancer therapy, the present review reveals it is interaction in Wnt signaling pathway that solely for colorectal cancer.
authors.affiliation: Department of Biomedical Science, School of Basic Medical Science, Bharathidasan University, Tiruchirappalli- 620 024, TN, India.
authors.forename: Boopathi
authors.initials: B
authors.lastname: Subramaniyan
authors.affiliation: Department of Biomedical Science, School of Basic Medical Science, Bharathidasan University, Tiruchirappalli- 620 024, TN, India.
authors.forename: Kaviya
authors.initials: K
authors.lastname: Jagadeesan
authors.affiliation: Department of Biomedical Science, School of Basic Medical Science, Bharathidasan University, Tiruchirappalli- 620 024, TN, India.
authors.forename: Sabitha
authors.initials: S
authors.lastname: Ramakrishnan
authors.affiliation: Department of Biomedical Science, School of Basic Medical Science, Bharathidasan University, Tiruchirappalli- 620 024, TN, India. Electronic address: mathan@bdu.ac.in.
authors.forename: Ganeshan
authors.initials: G
authors.lastname: Mathan
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology / Q000627:therapeutic use; D064127:Aurora Kinases / Q000378:metabolism*; D015179:Colorectal Neoplasms / Q000188:drug therapy* / Q000378:metabolism*; D006801:Humans; D011485:Protein Binding / Q000187:drug effects; D056564:Sirtuin 1 / Q000378:metabolism*; D060449:Wnt Signaling Pathway / Q000187:drug effects
chemical_list: D000970:Antineoplastic Agents; D064127:Aurora Kinases; D056564:Sirtuin 1
keywords: Aurora kinases; SIRT1; Wnt signaling pathway and colorectal cancer