title: An Electronic Health Record Investigation of Lenticulostriate Vasculopathy Features.
abstract: ObjectiveLenticulostriate vasculopathy (LSV) is characterized by linear hyperechogenicities in the basal ganglia found on the head ultrasounds of infants. We reviewed electronic health records of infants with and without LSV to investigate whether physician dictations indicated symptoms which could reflect subtle basal ganglia injury.Study DesignIn a case-control study, we analyzed data from 46 infants with LSV and 127 controls. Infants were stratified between term and preterm birth. Odds ratios (ORs) and 95% confidence intervals were calculated for tone abnormalities, apnea, feeding difficulties, seizures, and movement abnormalities in the presence of LSV.ResultsBoth term and preterm infants with LSV showed elevated risks for tone abnormalities (OR: 3.6 and 2.9, respectively). Term infants with LSV showed elevated risks for hypotonia (OR: 4.3), apnea (OR: 2.9), and feeding difficulties (OR: 4.1). Preterm infants with LSV showed elevated risks for truncal hypotonia (OR: 3.9) and hyperreflexia (OR: 3.9).ConclusionOur findings provide some evidence that LSV is associated with an increased risk of early signs of abnormal development, possibly relating to signs of subtle basal ganglia injury. Historically LSV has been considered incidental. The associations identified here suggest that LSV findings are worthy of further study.
authors.affiliation: Department of Pediatrics-Rheumatology, Stanford University, Stanford, California.
authors.forename: Jennifer
authors.initials: J
authors.lastname: Frankovich
authors.affiliation: Department of Pediatrics-Neonatology, Stanford University, Stanford, California.
authors.forename: Maximillian
authors.initials: M
authors.lastname: Egan
authors.affiliation: Department of Pediatrics-Rheumatology, Stanford University, Stanford, California.
authors.forename: Talia
authors.initials: T
authors.lastname: Mahony
authors.affiliation: Department of Pediatrics-Neonatology, Stanford University, Stanford, California.
authors.forename: William
authors.initials: W
authors.lastname: Benitz
authors.affiliation: Department of Pediatrics-Neonatology, Stanford University, Stanford, California.
authors.forename: Gary
authors.initials: G
authors.lastname: Shaw
mesh_terms: D001049:Apnea / Q000209:etiology*; D020144:Basal Ganglia Cerebrovascular Disease / Q000150:complications*; D016022:Case-Control Studies; D057286:Electronic Health Records; D001068:Feeding and Eating Disorders / Q000209:etiology*; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D009069:Movement Disorders / Q000209:etiology*; D009123:Muscle Hypotonia / Q000209:etiology*; D047928:Premature Birth; D012640:Seizures / Q000209:etiology*; D047929:Term Birth