title: [A Case of a Corneal Disorder after Breast Cancer Treatment with Nab-paclitaxel].
abstract: BACKGROUND
  We report a case of a corneal disorder after breast cancer treatment with a microtubule inhibitor, nab-paclitaxel (Abraxane).
  
  
  METHODS
  A 55-year-old woman, who was referred to our clinic, presented with blurred vision. 2 weeks previously, she had been undergoing treatment with nab-paclitaxel, trastuzumab and pertuzumab. Visual acuity was 20/60 in right eye and 20/40 in left eye. Slit-lamp examination showed an atypical epithelium invasion of the cornea in both eyes and small epithelial defect in left eye. After the nab-paclitaxel treatment was discontinued the corneal findings improved. 4 months later, visual acuity was 20/15 in right eye and 20/20 in left eye.
  
  
  CONCLUSIONS
  Nab-paclitaxel can cause severe corneal disorders, but the possibility that trastuzumab and pertuzumab combination therapy is associated with these disorders cannot be denied. Clinicians should consider the possibility of the side effects caused by systemic administration in cases of corneal disorders of uncertain etiology.
authors.forename: Yuka
authors.initials: Y
authors.lastname: Hosotani
authors.forename: Takanobu
authors.initials: T
authors.lastname: Morimatsu
authors.forename: Masashi
authors.initials: M
authors.lastname: Takata
authors.forename: Osamu
authors.initials: O
authors.lastname: Mimura
mesh_terms: D000418:Albumins / Q000008:administration & dosage / Q000009:adverse effects*; D061067:Antibodies, Monoclonal, Humanized / Q000008:administration & dosage; D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage / Q000009:adverse effects*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001943:Breast Neoplasms / Q000188:drug therapy*; D003316:Corneal Diseases / Q000139:chemically induced*; D005260:Female; D006801:Humans; D008875:Middle Aged; D017239:Paclitaxel / Q000008:administration & dosage / Q000009:adverse effects*; D000068878:Trastuzumab / Q000008:administration & dosage; D014792:Visual Acuity / Q000187:drug effects*
chemical_list: C520255:130-nm albumin-bound paclitaxel; D000418:Albumins; D061067:Antibodies, Monoclonal, Humanized; D000972:Antineoplastic Agents, Phytogenic; C485206:pertuzumab; D000068878:Trastuzumab; D017239:Paclitaxel