title: Atypical teratoid/rhabdoid tumor arising in a malignant glioma.
abstract: Atypical teratoid/rhabdoid tumor (AT/RT), a highly malignant brain tumor in young children, usually arises de novo and has only rarely been described as a secondary malignancy. Here, we present a case of a child with glioblastoma, who was treated postoperatively by a combination of temozolomide, irradiation, and bevacizumab. AT/RT was diagnosed as a secondary tumor, 2.5 years following primary diagnosis. The child died 13 months after the diagnosis of AT/RT. This case demonstrates that malignant gliomas may give rise to AT/RT. It also emphasizes the diagnostic value of a repeated tumor biopsy in the recurrence setting.
authors.affiliation: 2nd Department of Pediatrics, Semmelweis University, Budapest, Hungary.
authors.forename: Barbara
authors.initials: B
authors.lastname: Bozzai
authors.affiliation: Department of Neuropathology, Institute of Neuropathology, University Hospital Münster, Münster, Germany.
authors.forename: Martin
authors.initials: M
authors.lastname: Hasselblatt
authors.affiliation: 1st Department of Pathology and Experimental Cancer Research, Semmelweis University, Budapest, Hungary.
authors.forename: Eszter
authors.initials: E
authors.lastname: Turányi
authors.affiliation: Department of Oncology, Children's Hospital and Swabian Children's Cancer Center, Augsburg, Germany.
authors.forename: Michael C
authors.initials: MC
authors.lastname: Frühwald
authors.affiliation: Department of Human Genetics, Institute of Human Genetics, Christian-Albrechts-University Kiel, Kiel, Germany.|Department of Human Genetics, Institute of Human Genetics, University of Ulm, Ulm, Germany.
authors.forename: Reiner
authors.initials: R
authors.lastname: Siebert
authors.affiliation: Department of Human Genetics, Institute of Human Genetics, Christian-Albrechts-University Kiel, Kiel, Germany.|Department of Human Genetics, Institute of Human Genetics, University of Ulm, Ulm, Germany.
authors.forename: Susanne
authors.initials: S
authors.lastname: Bens
authors.affiliation: Department of Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
authors.forename: Reinhard
authors.initials: R
authors.lastname: Schneppenheim
authors.affiliation: Division of Pediatric Neurooncology, German Cancer Research Center DKFZ, Heidelberg, Germany.|German Cancer Consortium, Core Center Heidelberg, Heidelberg, Germany.
authors.forename: Marcel
authors.initials: M
authors.lastname: Kool
authors.affiliation: Department of Radiotherapy, National Institute of Oncology, Budapest, Hungary.
authors.forename: Gábor
authors.initials: G
authors.lastname: Stelczer
authors.affiliation: Division of Neuropathology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary.
authors.forename: Tibor
authors.initials: T
authors.lastname: Hortobágyi
authors.affiliation: 2nd Department of Pediatrics, Semmelweis University, Budapest, Hungary.
authors.forename: Peter
authors.initials: P
authors.lastname: Hauser
mesh_terms: D002675:Child, Preschool; D003131:Combined Modality Therapy; D005260:Female; D005910:Glioma / Q000473:pathology / Q000628:therapy*; D006801:Humans; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis* / Q000209:etiology; D009367:Neoplasm Staging; D016609:Neoplasms, Second Primary / Q000175:diagnosis* / Q000209:etiology; D011379:Prognosis; D018335:Rhabdoid Tumor / Q000175:diagnosis* / Q000209:etiology; D013724:Teratoma / Q000175:diagnosis* / Q000209:etiology
keywords: atypical teratoid/rhabdoid tumor; glioblastoma; irradiation; pleomorphic xanthoastrocytoma; temozolomide; therapy-induced secondary tumor