title: Illuminating Flash Point: Comprehensive Prediction Models.
abstract: Flash point is an important property of chemical compounds that is widely used to evaluate flammability hazard. However, there is often a significant gap between the demand for experimental flash point data and their availability. Furthermore, the determination of flash point is difficult and costly, particularly for some toxic, explosive, or radioactive compounds. The development of a reliable and widely applicable method to predict flash point is therefore essential. In this paper, the construction of a quantitative structure - property relationship model with excellent performance and domain of applicability is reported. It uses the largest data set to date of 9399 chemically diverse compounds, with flash point spanning from less than -130 °C to over 900 °C. The model employs only computed parameters, eliminating the need for experimental data that some earlier computational models required. The model allows accurate prediction of flash point for a broad range of compounds that are unavailable or not yet synthesized. This single model with a very broad range of chemical and flash point applicability will allow accurate predictions of this important property to be made for a broad range of new materials.
authors.affiliation: CSIRO Manufacturing Flagship, Private Bag 10, Clayton South MDC, VIC, 3169, Australia.
authors.forename: Tu C
authors.initials: TC
authors.lastname: Le
authors.affiliation: CSIRO Manufacturing Flagship, Private Bag 10, Clayton South MDC, VIC, 3169, Australia.
authors.forename: Mathew
authors.initials: M
authors.lastname: Ballard
authors.affiliation: CSIRO Manufacturing Flagship, Private Bag 10, Clayton South MDC, VIC, 3169, Australia.
authors.forename: Phillip
authors.initials: P
authors.lastname: Casey
authors.affiliation: CSIRO Digital Productivity Flagship, Private Bag 33, Clayton South MDC, VIC, 3169, Australia.
authors.forename: Ming S
authors.initials: MS
authors.lastname: Liu
authors.affiliation: CSIRO Manufacturing Flagship, Private Bag 10, Clayton South MDC, VIC, 3169, Australia. dave.winkler@csiro.au.|Monash Institute of Pharmaceutical Sciences, Parkville, VIC, 3052, Australia tel: +61 3 9545 2477. dave.winkler@csiro.au.|Latrobe Institute for Molecular Sciences bun doors, VIC, 3086, Australia. dave.winkler@csiro.au.
authors.forename: David A
authors.initials: DA
authors.lastname: Winkler
mesh_terms: D062126:Databases, Chemical; D008956:Models, Chemical
keywords: Domain of applicability; Flash point; Neural network; Quantitative structure-property relationship; Robust model prediction