title: Hydroxytyrosol modulates Par j 1-induced IL-10 production by PBMCs in healthy subjects.
abstract: Several papers have demonstrated the importance of substances from natural sources which can exert powerful anti-inflammatory effects. In this respect, hydroxytyrosol, one of the major elements of the phenolic components of olive oil, has been extensively studied for its anti-inflammatory activities and safety profile. In this report, we demonstrate that the co-stimulation of human PBMCs from healthy subjects with the Par j 1 allergen and hydroxytyrosol induced a statistically significant increase in the amount of Par j 1-induced IL-10, demonstrating that hydroxytyrosol can modulate an allergen-specific immune response potentiating a suppressive immune response towards an allergen. Our work opens the way to further studies to elaborate the possibility of using hydroxytyrosol as a nutrient for allergy prevention.
authors.affiliation: Istituto di Biomedicina e di Immunologia Molecolare del Consiglio Nazionale delle Ricerche, Via Ugo La Malfa 153, 90146 Palermo, Italy.
authors.forename: Angela
authors.initials: A
authors.lastname: Bonura
authors.affiliation: Istituto di Biomedicina e di Immunologia Molecolare del Consiglio Nazionale delle Ricerche, Via Ugo La Malfa 153, 90146 Palermo, Italy.
authors.forename: Sara
authors.initials: S
authors.lastname: Vlah
authors.affiliation: Istituto di Biomedicina e di Immunologia Molecolare del Consiglio Nazionale delle Ricerche, Via Ugo La Malfa 153, 90146 Palermo, Italy.
authors.forename: Alessandra
authors.initials: A
authors.lastname: Longo
authors.affiliation: Istituto di Biomedicina e di Immunologia Molecolare del Consiglio Nazionale delle Ricerche, Via Ugo La Malfa 153, 90146 Palermo, Italy.
authors.forename: Matteo
authors.initials: M
authors.lastname: Bulati
authors.affiliation: Istituto di Biomedicina e di Immunologia Molecolare del Consiglio Nazionale delle Ricerche, Via Ugo La Malfa 153, 90146 Palermo, Italy.
authors.forename: Mario R
authors.initials: MR
authors.lastname: Melis
authors.affiliation: Istituto di Biomedicina e di Immunologia Molecolare del Consiglio Nazionale delle Ricerche, Via Ugo La Malfa 153, 90146 Palermo, Italy.
authors.forename: Fabio
authors.initials: F
authors.lastname: Cibella
authors.affiliation: Istituto di Biomedicina e di Immunologia Molecolare del Consiglio Nazionale delle Ricerche, Via Ugo La Malfa 153, 90146 Palermo, Italy. Electronic address: paolo.colombo@ibim.cnr.it.
authors.forename: Paolo
authors.initials: P
authors.lastname: Colombo
mesh_terms: D000485:Allergens / Q000276:immunology; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D052179:Antigens, Plant / Q000276:immunology; D002478:Cells, Cultured; D004032:Diet; D006801:Humans; D006967:Hypersensitivity / Q000178:diet therapy* / Q000276:immunology; D056747:Immunomodulation; D016753:Interleukin-10 / Q000378:metabolism; D007963:Leukocytes, Mononuclear / Q000187:drug effects* / Q000276:immunology; D000069463:Olive Oil; D010626:Phenylethyl Alcohol / Q000031:analogs & derivatives* / Q000494:pharmacology; D010940:Plant Proteins / Q000276:immunology; D027003:Urticaceae / Q000276:immunology
chemical_list: D000485:Allergens; D000893:Anti-Inflammatory Agents; D052179:Antigens, Plant; D000069463:Olive Oil; C105336:PMAI protein, Parietaria judaica; D010940:Plant Proteins; C005975:3,4-dihydroxyphenylethanol; D016753:Interleukin-10; D010626:Phenylethyl Alcohol