title: Splanchnic Oxygenation at First Enteral Feeding in Preterm Infants: Correlation With Feeding Intolerance.
abstract: Preterm infants are at risk of developing gastrointestinal complications such as feeding intolerance and necrotizing enterocolitis. Near-infrared spectroscopy (NIRS) provides continuous monitoring of abdominal oxygenation (ArSO2) and could help to predict gastrointestinal complications in preterm neonates. In this prospective observational study, ArSO2 patterns at first enteral feed were evaluated by NIRS in 61 clinically stable preterm infants. Splanchnic-cerebral oxygenation ratio, which is a marker of gut hypoxia, was also calculated. ArSO2 and splanchnic-cerebral oxygenation ratio were significantly lower both at baseline and after feeding administration in infants who later developed feeding intolerance (n = 23). NIRS could help the early prediction of gastrointestinal complications in high-risk preterm infants.
authors.affiliation: *Neonatology and Neonatal Intensive Care Unit, Department of Medical and Surgical Sciences, St. Orsola-Malpighi Hospital †Department of Biomedical and Neuromotor Sciences (DIBINEM), Division of Hygiene and Biostatistics, University of Bologna, Bologna, Italy.
authors.forename: Luigi
authors.initials: L
authors.lastname: Corvaglia
authors.forename: Silvia
authors.initials: S
authors.lastname: Martini
authors.forename: Barbara
authors.initials: B
authors.lastname: Battistini
authors.forename: Paola
authors.initials: P
authors.lastname: Rucci
authors.forename: Giacomo
authors.initials: G
authors.lastname: Faldella
authors.forename: Arianna
authors.initials: A
authors.lastname: Aceti
mesh_terms: D015415:Biomarkers / Q000378:metabolism; D004750:Enteral Nutrition / Q000009:adverse effects*; D005260:Female; D005767:Gastrointestinal Diseases / Q000175:diagnosis / Q000209:etiology* / Q000378:metabolism; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D007235:Infant, Premature, Diseases / Q000175:diagnosis / Q000209:etiology* / Q000378:metabolism; D008297:Male; D010100:Oxygen / Q000378:metabolism*; D011446:Prospective Studies; D018570:Risk Assessment; D012307:Risk Factors; D019265:Spectroscopy, Near-Infrared; D013152:Splanchnic Circulation
chemical_list: D015415:Biomarkers; D010100:Oxygen