title: The role of microRNAs in metabolic interactions between viruses and their hosts.
abstract: Productive viral infection requires changes to the cellular metabolic landscape in order to obtain the building blocks and create the microenvironments necessary for the viral life cycle. In mammals, these alterations of metabolic pathways have been shown to be mediated in part by host and virus-encoded microRNAs. To counteract virally-induced changes in the cellular metabolic profile, the interferon-regulated antiviral response restricts viral access to key metabolites by altering cellular metabolism, mediated through induction of specific microRNAs regulating key lipid biosynthetic processes. In this review, we examine recent studies demonstrating the important role of microRNAs in the regulation of metabolic flux during viral infection.
authors.affiliation: Department of Chemistry and Biomolecular Sciences, Faculty of Science, University of Ottawa, 10 Marie Curie, Ottawa, Ontario, Canada K1N 6N5.
authors.forename: Megan H
authors.initials: MH
authors.lastname: Powdrill
authors.affiliation: Department of Chemistry and Biomolecular Sciences, Faculty of Science, University of Ottawa, 10 Marie Curie, Ottawa, Ontario, Canada K1N 6N5.
authors.forename: Geneviève F
authors.initials: GF
authors.lastname: Desrochers
authors.affiliation: Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, 451 Smyth Road, Ottawa, Ontario, Canada K1H 8M5. Electronic address: R.Singaravelu@gmail.com.
authors.forename: Ragunath
authors.initials: R
authors.lastname: Singaravelu
authors.affiliation: Department of Chemistry and Biomolecular Sciences, Faculty of Science, University of Ottawa, 10 Marie Curie, Ottawa, Ontario, Canada K1N 6N5; Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, 451 Smyth Road, Ottawa, Ontario, Canada K1H 8M5. Electronic address: John.Pezacki@uottawa.ca.
authors.forename: John Paul
authors.initials: JP
authors.lastname: Pezacki
mesh_terms: D000818:Animals; D054884:Host-Pathogen Interactions; D006801:Humans; D007372:Interferons / Q000276:immunology; D050356:Lipid Metabolism; D035683:MicroRNAs / Q000378:metabolism*; D012367:RNA, Viral / Q000378:metabolism; D014777:Virus Diseases / Q000378:metabolism*; D018406:Virus Physiological Phenomena; D014779:Virus Replication; D014780:Viruses / Q000472:pathogenicity
chemical_list: D035683:MicroRNAs; D012367:RNA, Viral; D007372:Interferons