title: Adipocytes and Neutrophils Give a Helping Hand to Pancreatic Cancers.
abstract: Obesity-induced inflammation can build up a confined microenvironment in pancreatic adenocarcinoma that is associated with increased desmoplasia, neutrophil recruitment, reduced delivery of chemotherapeutic drugs, and immune evasion. Targeting molecular pathways empowering this circuit might represent a necessary measure to reach clinical efficacy for combination therapies in patients with excess body weight. Cancer Discov; 6(8); 821-3. ©2016 AACR.See related article by Incio et al., p. 852.
authors.affiliation: Immunology, Department of Medicine, Verona University Hospital, Verona, Italy. vincenzo.bronte@univr.it.
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Bronte
authors.affiliation: Medical Oncology, Department of Medicine, Verona University Hospital, Verona, Italy.
authors.forename: Giampaolo
authors.initials: G
authors.lastname: Tortora
mesh_terms: D017667:Adipocytes / Q000378:metabolism*; D000818:Animals; D002450:Cell Communication; D016207:Cytokines / Q000378:metabolism; D006801:Humans; D018836:Inflammation Mediators / Q000378:metabolism; D014411:Neoplastic Stem Cells / Q000378:metabolism; D009504:Neutrophils / Q000276:immunology* / Q000378:metabolism*; D010190:Pancreatic Neoplasms / Q000209:etiology* / Q000378:metabolism* / Q000473:pathology / Q000628:therapy; D059016:Tumor Microenvironment
chemical_list: D016207:Cytokines; D018836:Inflammation Mediators