title: Role of race in kidney transplant outcomes in children with focal segmental glomerulosclerosis.
abstract: It is well established that racial differences exist in kidney transplant outcomes; however, there are no studies which focus on the role of race in transplant outcomes specifically in children diagnosed with FSGS. Associations between race and transplant outcomes in FSGS children were evaluated using the Organ Procurement and Transplantation Network database from 2000 to 2012. Recipients aged 2-21 years who received a kidney-only transplant were included. Multivariate regression models were used to evaluate transplant outcomes by race. Five hundred and thirty-six recipients (59.7% male, 15.6±3.9 years) were black and 1134 (55.7% male, 14.3±5.0 years) were non-black. Graft survival was significantly shorter in the black group (4.2±3.1 vs 4.6±3.3 years, P=.005). Black race was associated with significantly higher risk of graft failure (HR 1.34, 95% CI=1.21-1.49, P<.0001), acute rejection (OR 1.66 95% CI=1.39-1.97, P<.0001), and delayed graft function (OR 1.51, 95% CI=1.33-1.72, P<.001) compared to non-black race. There were no significant differences in mortality, prolonged hospitalization, or FSGS recurrence between groups. Race is a significant predictor for worse transplant outcomes in children with FSGS.
authors.affiliation: Division of Nephrology, Department of Pediatrics, Cohen Children's Medical Center of New York, New Hyde Park, NY, USA.
authors.forename: Ivan
authors.initials: I
authors.lastname: Guan
authors.affiliation: Division of Nephrology, Department of Pediatrics, Cohen Children's Medical Center of New York, New Hyde Park, NY, USA.
authors.forename: Pamela
authors.initials: P
authors.lastname: Singer
authors.affiliation: Division of Nephrology, Department of Pediatrics, Cohen Children's Medical Center of New York, New Hyde Park, NY, USA.
authors.forename: Rachel
authors.initials: R
authors.lastname: Frank
authors.affiliation: Division of Nephrology, Department of Pediatrics, Cohen Children's Medical Center of New York, New Hyde Park, NY, USA.
authors.forename: Nataliya
authors.initials: N
authors.lastname: Chorny
authors.affiliation: Division of Nephrology, Department of Pediatrics, Cohen Children's Medical Center of New York, New Hyde Park, NY, USA.
authors.forename: Lulette
authors.initials: L
authors.lastname: Infante
authors.affiliation: Division of Nephrology, Department of Pediatrics, Cohen Children's Medical Center of New York, New Hyde Park, NY, USA.
authors.forename: Christine B
authors.initials: CB
authors.lastname: Sethna
mesh_terms: D000293:Adolescent; D001741:Black or African American; D002648:Child; D002675:Child, Preschool; D016208:Databases, Factual; D051799:Delayed Graft Function / Q000208:ethnology*; D005260:Female; D005500:Follow-Up Studies; D005923:Glomerulosclerosis, Focal Segmental / Q000208:ethnology / Q000401:mortality / Q000601:surgery*; D006084:Graft Rejection / Q000208:ethnology*; D006085:Graft Survival; D054624:Health Status Disparities; D006801:Humans; D016030:Kidney Transplantation / Q000401:mortality; D007902:Length of Stay / Q000706:statistics & numerical data; D008297:Male; D012008:Recurrence; D012044:Regression Analysis; D012189:Retrospective Studies; D012307:Risk Factors; D016019:Survival Analysis; D014481:United States; D055815:Young Adult
keywords: outcomes; pediatric; renal transplant