title: Migration Suppression of Small Cell Lung Cancer by Polysaccharides from Nostoc commune Vaucher.
abstract: Nostoc commune Vauch., classified into cyanobacteria, has been always well appreciated as a healthy food and medicine worldwide owing to its rich nutrition and potent bioactivities. Nevertheless, the inhibitory effect of polysaccharides from N. commune Vauch. (NVPS) against cancer cell progression and metastasis is still being unraveled. The results in this study showed that NVPS remarkably suppressed cell migration through blocking the epithelial-mesenchymal transition program in NCI-H446 and NCI-H1688 human small cell lung cancer cells. The inhibitory effects were attributed to the suppression of integrin β1/FAK signaling through regulating cell-matrix adhesion. Furthermore, NVPS treatment could increase E-cadherin expression, but down-regulate N-cadherin, Vimentin, and MMP-9 expression, which resulted in the blockage of STAT3 nuclear translocation and JAK1 signaling. These findings suggest that NVPS may be a good candidate for development as a possible antitumor agent against small cell lung cancer.
authors.affiliation: College of Life Science and ‡Institute of Biotechnology, the Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education, Shanxi University , Taiyuan 030006, China.
authors.forename: Min
authors.initials: M
authors.lastname: Guo
authors.affiliation: College of Life Science and ‡Institute of Biotechnology, the Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education, Shanxi University , Taiyuan 030006, China.
authors.forename: Guo-Bin
authors.initials: GB
authors.lastname: Ding
authors.affiliation: College of Life Science and ‡Institute of Biotechnology, the Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education, Shanxi University , Taiyuan 030006, China.
authors.forename: Peng
authors.initials: P
authors.lastname: Yang
authors.affiliation: College of Life Science and ‡Institute of Biotechnology, the Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education, Shanxi University , Taiyuan 030006, China.
authors.forename: Lichao
authors.initials: L
authors.lastname: Zhang
authors.affiliation: College of Life Science and ‡Institute of Biotechnology, the Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education, Shanxi University , Taiyuan 030006, China.
authors.forename: Haili
authors.initials: H
authors.lastname: Wu
authors.affiliation: College of Life Science and ‡Institute of Biotechnology, the Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education, Shanxi University , Taiyuan 030006, China.
authors.forename: Hanqing
authors.initials: H
authors.lastname: Li
authors.affiliation: College of Life Science and ‡Institute of Biotechnology, the Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education, Shanxi University , Taiyuan 030006, China.
authors.forename: Zhuoyu
authors.initials: Z
authors.lastname: Li
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology*; D015820:Cadherins / Q000235:genetics / Q000378:metabolism; D002465:Cell Movement / Q000187:drug effects; D015536:Down-Regulation / Q000187:drug effects; D015972:Gene Expression Regulation, Neoplastic / Q000187:drug effects; D006801:Humans; D019012:Integrin beta1 / Q000235:genetics / Q000378:metabolism; D008175:Lung Neoplasms / Q000188:drug therapy / Q000235:genetics / Q000378:metabolism / Q000503:physiopathology*; D009362:Neoplasm Metastasis; D050501:Nostoc commune / Q000737:chemistry*; D011134:Polysaccharides / Q000737:chemistry / Q000494:pharmacology*; D050796:STAT3 Transcription Factor / Q000235:genetics / Q000378:metabolism; D015398:Signal Transduction / Q000187:drug effects; D055752:Small Cell Lung Carcinoma / Q000188:drug therapy / Q000235:genetics / Q000378:metabolism / Q000503:physiopathology*; D014746:Vimentin / Q000235:genetics / Q000378:metabolism
chemical_list: D000970:Antineoplastic Agents; D015820:Cadherins; D019012:Integrin beta1; D011134:Polysaccharides; D050796:STAT3 Transcription Factor; D014746:Vimentin
keywords: Nostoc commune Vauch.; cell migration; epithelial−mesenchymal transition; polysaccharides; small cell lung cancer