title: Association between SKIV2L polymorphism rs429608 and age-related macular degeneration: A meta-analysis.
abstract: This study was conducted to comprehensively evaluate the potential association of SKIV2L polymorphism rs429608 with age-related macular degeneration (AMD) through a meta-analysis.
  
  
  
  We performed a literature search in EMBASE, PubMed, Web of Science, and the Chinese Biomedical Database for AMD genetic studies published before August 30, 2015. Odds ratios (ORs) and 95% confidence intervals (95% CIs) were calculated for single-nucleotide polymorphisms (SNPs) using fixed-effect models or random effect models according to between-study heterogeneity. Publication bias analyses were conducted using Egger's test.
  
  
  
  A total of five studies from published articles were included, and a total number of 2789 AMD cases and 3451 healthy controls were tested in this meta-analysis. The results demonstrated that SKIV2L rs429608 is associated with AMD under allelic model (A vs. G; OR = 0.52, 95% CI 0.44-0.62, p < 0.001), heterozygous model (AG vs. GG; OR = 0.51; 95%CI, 0.38-0.68; p < 0.001; PQ= 0.48; I2= 0) and dominant model (AA+AG vs. GG; OR = 0.49; 95%CI 0.37-0.65; p < 0.001; PQ= 0.44; I2= 0), but not under other genetic models.
  
  
  
  This meta-analysis showed that SKIV2L rs429608 was statistically associated with AMD and it might exert a protective effect on AMD. Further investigations are needed to validate the association and confirm the role of SKIV2L in AMD.
authors.affiliation: a College of Life Science and Engineering , Southwest Jiaotong University , Chengdu , China.|b Sichuan Provincial Key Laboratory for Human Disease Gene Study , Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China , Chengdu , China.|c Health Management Center , Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China , Chengdu , China.
authors.forename: Ping
authors.initials: P
authors.lastname: Shuai
authors.affiliation: a College of Life Science and Engineering , Southwest Jiaotong University , Chengdu , China.|b Sichuan Provincial Key Laboratory for Human Disease Gene Study , Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China , Chengdu , China.
authors.forename: Zimeng
authors.initials: Z
authors.lastname: Ye
authors.affiliation: c Health Management Center , Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China , Chengdu , China.
authors.forename: Yuping
authors.initials: Y
authors.lastname: Liu
authors.affiliation: d Department of Ophthalmology , Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China , Chengdu , China.
authors.forename: Chao
authors.initials: C
authors.lastname: Qu
authors.affiliation: a College of Life Science and Engineering , Southwest Jiaotong University , Chengdu , China.|b Sichuan Provincial Key Laboratory for Human Disease Gene Study , Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China , Chengdu , China.
authors.forename: Xiaoqi
authors.initials: X
authors.lastname: Liu
authors.affiliation: b Sichuan Provincial Key Laboratory for Human Disease Gene Study , Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China , Chengdu , China.
authors.forename: Huaichao
authors.initials: H
authors.lastname: Luo
authors.affiliation: b Sichuan Provincial Key Laboratory for Human Disease Gene Study , Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China , Chengdu , China.
authors.forename: Xiaoyun
authors.initials: X
authors.lastname: Feng
authors.affiliation: b Sichuan Provincial Key Laboratory for Human Disease Gene Study , Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China , Chengdu , China.
authors.forename: Xiulan
authors.initials: X
authors.lastname: Li
authors.affiliation: a College of Life Science and Engineering , Southwest Jiaotong University , Chengdu , China.|b Sichuan Provincial Key Laboratory for Human Disease Gene Study , Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China , Chengdu , China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Shi
authors.affiliation: b Sichuan Provincial Key Laboratory for Human Disease Gene Study , Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China , Chengdu , China.
authors.forename: Bo
authors.initials: B
authors.lastname: Gong
mesh_terms: D000483:Alleles; D017242:Complement Factor H / Q000235:genetics; D004265:DNA Helicases / Q000235:genetics*; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006801:Humans; D008268:Macular Degeneration / Q000235:genetics*; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors
chemical_list: D017242:Complement Factor H; D004265:DNA Helicases; C114718:SKIV2L protein, human
keywords: AMD; SKIV2L; SNP; meta-analysis