title: Meeting physical activity recommendations may be protective against temporal lobe atrophy in older adults at risk for Alzheimer's disease.
abstract: BACKGROUND
  Physical activity (PA) is associated with brain health in older adults. However, it is unknown whether the current physical activity recommendations (PAR) impart substantive benefit. The objective of this study was to compare temporal lobe volumes between older adults who met PAR and those who did not.
  
  
  METHODS
  Ninety-one enrollees from the Wisconsin Registry for Alzheimer's Prevention wore an accelerometer for seven consecutive days to quantify their PA behaviors and underwent a T-1 anatomic magnetic resonance imaging scan. Participants were categorized as either having met PAR or not based on the US Department of Health and Human Services recommendations of 150 minutes of moderate-to-vigorous physical activity per week.
  
  
  RESULTS
  Participants who met PAR possessed significantly greater inferior (η(2) P  = .050) and anterior (η(2) P  = .055) temporal lobe volumes compared with those who did not (P < .05).
  
  
  CONCLUSIONS
  Individuals at-risk for AD experience accelerated rates of brain atrophy. These results suggest that regular engagement in PA at or above PAR could attenuate this decline.
authors.affiliation: William S. Middleton Memorial Veterans Hospital, Madison, WI, USA; Department of Kinesiology, University of Wisconsin School of Education, Madison, WI, USA.
authors.forename: Ryan J
authors.initials: RJ
authors.lastname: Dougherty
authors.affiliation: William S. Middleton Memorial Veterans Hospital, Madison, WI, USA; Department of Kinesiology, Iowa State University College of Human Sciences, Ames, IA, USA.
authors.forename: Laura D
authors.initials: LD
authors.lastname: Ellingson
authors.affiliation: Geriatric Research Education and Clinical Center, William S. Middleton Memorial Veterans Hospital, Madison, WI, USA; Wisconsin Alzheimer's Disease Research Center, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA; Wisconsin Alzheimer's Institute, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
authors.forename: Stephanie A
authors.initials: SA
authors.lastname: Schultz
authors.affiliation: Geriatric Research Education and Clinical Center, William S. Middleton Memorial Veterans Hospital, Madison, WI, USA; Wisconsin Alzheimer's Disease Research Center, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA; Wisconsin Alzheimer's Institute, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
authors.forename: Elizabeth A
authors.initials: EA
authors.lastname: Boots
authors.affiliation: William S. Middleton Memorial Veterans Hospital, Madison, WI, USA; Department of Family Medicine and Community Health, University of Wisconsin, Madison, WI, USA.
authors.forename: Jacob D
authors.initials: JD
authors.lastname: Meyer
authors.affiliation: William S. Middleton Memorial Veterans Hospital, Madison, WI, USA; Department of Kinesiology, University of Wisconsin School of Education, Madison, WI, USA.
authors.forename: Jacob B
authors.initials: JB
authors.lastname: Lindheimer
authors.affiliation: William S. Middleton Memorial Veterans Hospital, Madison, WI, USA; Department of Kinesiology, University of Wisconsin School of Education, Madison, WI, USA.
authors.forename: Stephanie
authors.initials: S
authors.lastname: Van Riper
authors.affiliation: William S. Middleton Memorial Veterans Hospital, Madison, WI, USA; Department of Kinesiology, University of Wisconsin School of Education, Madison, WI, USA.
authors.forename: Aaron J
authors.initials: AJ
authors.lastname: Stegner
authors.affiliation: Department of Kinesiology, University of Wisconsin School of Education, Madison, WI, USA; Wisconsin Alzheimer's Disease Research Center, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA; Wisconsin Alzheimer's Institute, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
authors.forename: Dorothy F
authors.initials: DF
authors.lastname: Edwards
authors.affiliation: Geriatric Research Education and Clinical Center, William S. Middleton Memorial Veterans Hospital, Madison, WI, USA; Wisconsin Alzheimer's Disease Research Center, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA; Wisconsin Alzheimer's Institute, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
authors.forename: Jennifer M
authors.initials: JM
authors.lastname: Oh
authors.affiliation: Wisconsin Alzheimer's Institute, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
authors.forename: Rebecca L
authors.initials: RL
authors.lastname: Koscik
authors.affiliation: Department of Biostatistics & Medical Informatics, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
authors.forename: Maritza N
authors.initials: MN
authors.lastname: Dowling
authors.affiliation: Geriatric Research Education and Clinical Center, William S. Middleton Memorial Veterans Hospital, Madison, WI, USA; Wisconsin Alzheimer's Disease Research Center, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
authors.forename: Catherine L
authors.initials: CL
authors.lastname: Gallagher
authors.affiliation: Geriatric Research Education and Clinical Center, William S. Middleton Memorial Veterans Hospital, Madison, WI, USA; Wisconsin Alzheimer's Disease Research Center, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
authors.forename: Cynthia M
authors.initials: CM
authors.lastname: Carlsson
authors.affiliation: Wisconsin Alzheimer's Disease Research Center, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
authors.forename: Howard A
authors.initials: HA
authors.lastname: Rowley
authors.affiliation: Geriatric Research Education and Clinical Center, William S. Middleton Memorial Veterans Hospital, Madison, WI, USA; Wisconsin Alzheimer's Disease Research Center, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA; Wisconsin Alzheimer's Institute, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
authors.forename: Barbara B
authors.initials: BB
authors.lastname: Bendlin
authors.affiliation: Geriatric Research Education and Clinical Center, William S. Middleton Memorial Veterans Hospital, Madison, WI, USA; Wisconsin Alzheimer's Disease Research Center, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
authors.forename: Sanjay
authors.initials: S
authors.lastname: Asthana
authors.affiliation: Wisconsin Alzheimer's Disease Research Center, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA; Wisconsin Alzheimer's Institute, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA; Department of Neurology, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
authors.forename: Bruce P
authors.initials: BP
authors.lastname: Hermann
authors.affiliation: Wisconsin Alzheimer's Disease Research Center, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA; Wisconsin Alzheimer's Institute, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
authors.forename: Mark A
authors.initials: MA
authors.lastname: Sager
authors.affiliation: Geriatric Research Education and Clinical Center, William S. Middleton Memorial Veterans Hospital, Madison, WI, USA; Wisconsin Alzheimer's Disease Research Center, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA; Wisconsin Alzheimer's Institute, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
authors.forename: Sterling C
authors.initials: SC
authors.lastname: Johnson
authors.affiliation: Geriatric Research Education and Clinical Center, William S. Middleton Memorial Veterans Hospital, Madison, WI, USA; Wisconsin Alzheimer's Disease Research Center, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA; Wisconsin Alzheimer's Institute, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
authors.forename: Ozioma C
authors.initials: OC
authors.lastname: Okonkwo
authors.affiliation: William S. Middleton Memorial Veterans Hospital, Madison, WI, USA; Department of Kinesiology, University of Wisconsin School of Education, Madison, WI, USA.
authors.forename: Dane B
authors.initials: DB
authors.lastname: Cook
keywords: APOE ε4; Alzheimer's disease; Dementia; Exercise; Family history; Neuroimaging