title: Sleep and meal-time misalignment alters functional connectivity: a pilot resting-state study.
abstract: Delayed sleep and meal times promote metabolic dysregulation and obesity. Altered coordination of sleeping and eating times may impact food-reward valuation and interoception in the brain, yet the independent and collective contributions of sleep and meal times are unknown. This randomized, in-patient crossover study experimentally manipulates sleep and meal times while preserving sleep duration (7.05±0.44 h for 5 nights). Resting-state functional magnetic resonance imaging scans (2 × 5-minute runs) were obtained for four participants (three males; 25.3±4.6 years), each completing all study phases (normal sleep/normal meal; late sleep/normal meal; normal sleep/late meal; and late sleep/late meal). Normal mealtimes were 1, 5, 11 and 12.5 h after awakening; late mealtimes were 4.5, 8.5, 14.5 and 16 h after awakening. Seed-based resting-state functional connectivity (RSFC) was computed for a priori regions-of-interest (seeds) and contrasted across conditions. Statistically significant (P<0.05, whole-brain corrected) regionally specific effects were found for multiple seeds. The strongest effects were linked to the amygdala: increased RSFC for late versus normal mealtimes (equivalent to skipping breakfast). A main effect of sleep and interaction with meal time were also observed. Preliminary findings support the feasibility of examining the effects of sleep and meal-time misalignment, independent of sleep duration, on RSFC in regions relevant to food reward and interoception.
authors.affiliation: The Child Study Center at NYU Langone Medical Center, New York, NY, USA.
authors.forename: Y N
authors.initials: YN
authors.lastname: Yoncheva
authors.affiliation: The Child Study Center at NYU Langone Medical Center, New York, NY, USA.|Nathan Kline Institute for Psychiatric Research, Orangeburg, NY, USA.
authors.forename: F X
authors.initials: FX
authors.lastname: Castellanos
authors.affiliation: Department of Medicine, New York Obesity Research Center, Columbia University Medical Center, New York, NY, USA.
authors.forename: T
authors.initials: T
authors.lastname: Pizinger
authors.affiliation: Department of Medicine, New York Obesity Research Center, Columbia University Medical Center, New York, NY, USA.
authors.forename: K
authors.initials: K
authors.lastname: Kovtun
authors.affiliation: Department of Medicine, New York Obesity Research Center, Columbia University Medical Center, New York, NY, USA.|Institute of Human Nutrition, Columbia University Medical Center, New York, NY, USA.
authors.forename: M-P
authors.initials: MP
authors.lastname: St-Onge
mesh_terms: D000328:Adult; D015992:Body Mass Index; D001921:Brain / Q000502:physiology*; D001931:Brain Mapping; D018592:Cross-Over Studies; D005247:Feeding Behavior; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D062407:Meals / Q000502:physiology*; D009434:Neural Pathways; D010865:Pilot Projects; D012146:Rest / Q000502:physiology*; D012890:Sleep / Q000502:physiology*; D014481:United States