title: Ovarian cancer chemokines may not be a significant barrier during whole tumor antigen dendritic-cell vaccine and adoptive T-cell immunotherapy.
abstract: Tumor barriers preventing T-cell homing and engraftment should be neutralized during cancer immunotherapy. We recently discovered that ovarian cancer expresses quasi-universal chemokines that can support T-cell homing. Furthermore, T cells elicited by whole tumor antigen dendritic-cell vaccines express cognate chemokine receptors which are upregulated by CD3/CD28 costimulation.
authors.affiliation: Ovarian Cancer Research Center, University of Pennsylvania, Philadelphia, PA; Department of Gynecologic Oncology, Roswell Park Cancer Institute, Buffalo, NY; Center for Immunotherapy, Roswell Park Cancer Institute, Buffalo, NY.
authors.forename: Emese
authors.initials: E
authors.lastname: Zsiros
authors.affiliation: Ovarian Cancer Research Center, University of Pennsylvania, Philadelphia, PA; Ludwig Cancer Research Center, University of Lausanne, Lausanne, Switzerland.
authors.forename: Denarda
authors.initials: D
authors.lastname: Dangaj
authors.affiliation: Department of Pathology & Laboratory Medicine, University of Pennsylvania Philadelphia, PA.
authors.forename: Carl H
authors.initials: CH
authors.lastname: June
authors.affiliation: Ovarian Cancer Research Center, University of Pennsylvania, Philadelphia, PA; Ludwig Cancer Research Center, University of Lausanne, Lausanne, Switzerland; Department of Oncology, University Hospital of Lausanne, Switzerland.
authors.forename: Lana E
authors.initials: LE
authors.lastname: Kandalaft
authors.affiliation: Ovarian Cancer Research Center, University of Pennsylvania, Philadelphia, PA; Ludwig Cancer Research Center, University of Lausanne, Lausanne, Switzerland; Department of Oncology, University Hospital of Lausanne, Switzerland.
authors.forename: George
authors.initials: G
authors.lastname: Coukos
keywords: Adoptive T cell therapy; chemokines; immunotherapy; ovarian cancer