title: Fundamental effects of PD-1 antibody on the body: a brief report.
abstract: We report the case of a 61-year-old man with squamous cell carcinoma of the left lung and mediastinal lymph node metastases who received nivolumab and experienced a better antitumor effect than expected but died soon afterward. A clinical analysis showed that the grades of the treatment-related events did not cause death. The immunological impact of this treatment on his body, especially at his age and with concurrent infection, possibly augmented by the blockade of the PD-1/PD-L1 signaling pathway, is proposed to be one of the key factors for his death. Consequently, we suggest that the cellular immune status and the clinical characteristics of patients, especially the symptoms like concurrent infection, should be considered in the design of clinical protocol of such a kind of therapy.
authors.affiliation: Cancer Therapy Center.
authors.forename: Wei
authors.initials: W
authors.lastname: Wang
authors.affiliation: Cancer Therapy Center.
authors.forename: Bing
authors.initials: B
authors.lastname: Liu
authors.affiliation: Cancer Therapy Center.
authors.forename: Guangxian
authors.initials: G
authors.lastname: Liu
authors.affiliation: Department of Healthcare and Medicine, Affiliated Hospital of the Academy of Military Medical Sciences, Beijing, People's Republic of China.
authors.forename: Wanfeng
authors.initials: W
authors.lastname: Guo
keywords: PD-1; immunosuppression; immunotherapy; lung cancer; lung infection; nivolumab