title: Palladium-catalyzed β-(hetero)arylation of α,β-unsaturated valerolactams.
abstract: A method for the palladium-catalyzed arylation of α,β-unsaturated valerolactams is reported. This new protocol provides arylation products in yields up to 95% and is applicable to a wide array of aryl and heteroaryl bromides. The optimization, scope and limitations are described.
authors.affiliation: Pfizer Worldwide Medicinal Chemistry, Eastern Point Road, Groton, Connecticut 06340, USA. daniel.canterbury@pfizer.com.
authors.forename: Daniel P
authors.initials: DP
authors.lastname: Canterbury
authors.affiliation: Pfizer Worldwide Medicinal Chemistry, Eastern Point Road, Groton, Connecticut 06340, USA. daniel.canterbury@pfizer.com.
authors.forename: Kevin D
authors.initials: KD
authors.lastname: Hesp
authors.affiliation: Pfizer Worldwide Medicinal Chemistry, Eastern Point Road, Groton, Connecticut 06340, USA. daniel.canterbury@pfizer.com.
authors.forename: Jana
authors.initials: J
authors.lastname: Polivkova
mesh_terms: D002384:Catalysis; D006842:Hydrocarbons, Brominated / Q000138:chemical synthesis* / Q000737:chemistry; D007769:Lactams / Q000737:chemistry*; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry*
chemical_list: D006842:Hydrocarbons, Brominated; D007769:Lactams; C511520:valerolactam; D010165:Palladium