title: Gonadotoxic Effects of Nilotinib in Chronic Myeloid Leukemia Treatment Dose in a Mouse Model.
abstract: OBJECTIVE
  Tyrosine kinase inhibitors may have deleterious effects on spermatogenesis or folliculogenesis, resulting in male or female subfertility. The aim of this study is to determine the effect of nilotinib, which is used routinely to treat chronic myeloid leukemia, on spermatogenesis and folliculogenesis by using histopathological parameters.
  
  
  METHODS
  Ten male and ten female mice were orally treated with nilotinib at 20 mg/kg body weight dissolved in drinking water daily for 2 months.
  
  
  RESULTS
  When compared with the control group, a statistically significant decrease was demonstrated in the total follicle numbers of the female mice in the nilotinib group (268±110 vs. 170±60; p=0.03). Active spermatogenesis was observed in each tubule sample taken from the mice in the control and nilotinib groups. Spermatogenic activity was similar in the two groups.
  
  
  CONCLUSIONS
  We have demonstrated that even though spermatogenesis is preserved, folliculogenesis is inhibited by the usage of a continuous nilotinib treatment dose in chronic myeloid leukemia.
authors.affiliation: Ufuk University Faculty of Medicine, Department of Hematology, Ankara, Turkey E-mail: guldanecengiz@gmail.com.
authors.forename: Güldane
authors.initials: G
authors.lastname: Cengiz Seval
authors.forename: Sinan
authors.initials: S
authors.lastname: Özkavukçu
authors.forename: Murat
authors.initials: M
authors.lastname: Seval
authors.forename: Meltem
authors.initials: M
authors.lastname: Aylı
mesh_terms: D000818:Animals; D005260:Female; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000188:drug therapy / Q000378:metabolism / Q000473:pathology; D008297:Male; D051379:Mice; D009374:Neoplasms, Experimental / Q000188:drug therapy / Q000378:metabolism / Q000473:pathology; D006080:Ovarian Follicle / Q000378:metabolism / Q000473:pathology; D011743:Pyrimidines / Q000009:adverse effects* / Q000494:pharmacology; D013091:Spermatogenesis / Q000187:drug effects*
chemical_list: D011743:Pyrimidines; C498826:nilotinib