title: Conclusions: Calls to action for improving the life of MS patients and their families.
abstract: The first and second Pan-European MS Multi-stakeholder Colloquia were set up to increase cross-talk and communication between the different stakeholders in MS and developed joint Calls to Action to improve (equal) access to quality care and treatment for MS in Europe.
  
  
  
  To summarise the 10 integrated and interrelated Calls to Action developed.
  
  
  
  Call 1: increase awareness in the European community about the burden MS places on patients, caregivers and society. Call 2: improve communication towards the European community on the direct and indirect cost burden of MS. Call 3: perform patient research to (re)define treatment goals/endpoints from a humanistic/patient perspective point of view. Call 4: develop new tools to better capture the total clinical burden of MS. Call 5: develop a protocol for standardisation of MRI for optimising its use as a marker of disability progression in MS. Call 6: support research to find other (molecular) biomarkers which can predict long-term disability progression and (monitor) individual treatment response. Call 7: align CHMP/EMA and HTA decision-making process. Call 8: develop separate EMA guidelines for evaluating follow-on products of non-biological complex drugs. Call 9: support people with MS remaining (physically) active and at work and stimulate the implementation of specialised care centres. Call 10: support the continuation of multi-stakeholder colloquia.
authors.affiliation: Department of Neurology, University of Lille, CHRU de Lille, Lille International Research Inflammation Center (LIRIC), INSRRM U995, FHU Imminent, Lille, France patrick.vermersch@univ-lille2.fr.
authors.forename: Patrick
authors.initials: P
authors.lastname: Vermersch
authors.affiliation: Managing Director at Ismar Healthcare, Lier, Belgium.
authors.forename: Louis
authors.initials: L
authors.lastname: Smets
authors.affiliation: Department of Neurology, St. Josef-Hospital, Ruhr University Bochum, Bochum, Germany.
authors.forename: Ralf
authors.initials: R
authors.lastname: Gold
mesh_terms: D000066491:Clinical Decision-Making; D003299:Cooperative Behavior; D017281:Cost of Illness; D004185:Disability Evaluation; D006801:Humans; D033183:Interdisciplinary Communication; D008279:Magnetic Resonance Imaging; D009103:Multiple Sclerosis / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000523:psychology / Q000628:therapy*; D010358:Patient Participation; D011379:Prognosis; D058996:Quality Improvement; D019984:Quality Indicators, Health Care; D011788:Quality of Life; D000073597:Stakeholder Participation
keywords: Multiple sclerosis; clinician; multi-stakeholders; patient; payer; regulator