title: AURORA: bariatric surgery registration in women of reproductive age - a multicenter prospective cohort study.
abstract: The expansion of the obesity epidemic is accompanied with an increase in bariatric procedures, in particular in women of reproductive age. The weight loss induced by the surgery is believed to reverse the negative impact of overweight and obesity on female reproduction, however, research is limited to in particular retrospective cohort studies and a growing number of small case-series and case-(control) studies.
  
  
  
  AURORA is a multicenter prospective cohort study. The main objective is to collect long-term data on reproductive outcomes before and after bariatric surgery and in a subsequent pregnancy. Women aged 18-45 years are invited to participate at 4 possible inclusion moments: 1) before surgery, 2) after surgery, 3) before 15 weeks of pregnancy and 4) in the immediate postpartum period (day 3-4). Depending on the time of inclusion, data are collected before surgery (T1), 3 weeks and 3, 6, 12 or x months after surgery (T2-T5) and during the first, second and third trimester of pregnancy (T6-T8), at delivery (T9) and 6 weeks and 6 months after delivery (T10-T11). Online questionnaires are send on the different measuring moments. Data are collected on contraception, menstrual cycle, sexuality, intention of becoming pregnant, diet, physical activity, lifestyle, psycho-social characteristics and dietary supplement intake. Fasting blood samples determine levels of vitamin A, D, E, K, B-1, B-12 and folate, albumin, total protein, coagulation parameters, magnesium, calcium, zinc and glucose. Participants are weighted every measuring moment. Fetal ultrasounds and pregnancy course and complications are reported every trimester of pregnancy. Breastfeeding is recorded and breast milk composition in the postpartum period is studied.
  
  
  
  AURORA is a multicenter prospective cohort study extensively monitoring women before undergoing bariatric surgery until a subsequent pregnancy and postpartum period.
  
  
  
  Retrospectively registered (July 2015 - NCT02515214 ).
authors.affiliation: Department of Development and Regeneration, KU Leuven, Herestraat 49, 3000, Leuven, Belgium. goele.jans@med.kuleuven.be.
authors.forename: Goele
authors.initials: G
authors.lastname: Jans
authors.affiliation: Department of Clinical and Experimental Medicine, KU Leuven, Herestraat 49, 3000, Leuven, Belgium.|Department of Endocrinology, University Hospitals Leuven, Herestraat 49, 3000, Leuven, Belgium.
authors.forename: Christophe
authors.initials: C
authors.lastname: Matthys
authors.affiliation: Scientific Institute of Public Health, Department of Public Health and Surveillance, Unit Surveys, Lifestyle and Chronic Diseases, Juliette Wytsmanstraat 14, 1050, Brussels, Belgium.
authors.forename: Sarah
authors.initials: S
authors.lastname: Bel
authors.affiliation: Department of Development and Regeneration, KU Leuven, Herestraat 49, 3000, Leuven, Belgium.
authors.forename: Lieveke
authors.initials: L
authors.lastname: Ameye
authors.affiliation: Department of Clinical and Experimental Medicine, KU Leuven, Herestraat 49, 3000, Leuven, Belgium.|Department of Abdominal Surgery, University Hospitals Leuven, Herestraat 49, 3000, Leuven, Belgium.
authors.forename: Matthias
authors.initials: M
authors.lastname: Lannoo
authors.affiliation: Department of Clinical and Experimental Medicine, KU Leuven, Herestraat 49, 3000, Leuven, Belgium.|Department of Endocrinology, University Hospitals Leuven, Herestraat 49, 3000, Leuven, Belgium.
authors.forename: Bart
authors.initials: B
authors.lastname: Van der Schueren
authors.affiliation: Department of Abdominal Surgery, St-Jan Hospital Bruges, Ruddershove 10, 8000, Bruges, Belgium.
authors.forename: Bruno
authors.initials: B
authors.lastname: Dillemans
authors.affiliation: Department of Abdominal Surgery, St-Nikolaas Hospital, Moerlandstraat 1, 9100, St-Niklaas, Belgium.
authors.forename: Luc
authors.initials: L
authors.lastname: Lemmens
authors.affiliation: Medicosurgical unit for metabolic diseases, CHR Mons Hainaut, 5 avenue Baudouin de Constantinople, 7000, Mons, Belgium.
authors.forename: Jean-Pierre
authors.initials: JP
authors.lastname: Saey
authors.affiliation: Department of Gastrointestinal Surgery, Ghent University Hospital, De Pintelaan 185, 9000, Ghent, Belgium.
authors.forename: Yves
authors.initials: Y
authors.lastname: van Nieuwenhove
authors.affiliation: Department of Obstetrics and Gynecology, CHR Mons Hainaut, 5 avenue Baudouin de Constantinople, 7000, Mons, Belgium.
authors.forename: Pascale
authors.initials: P
authors.lastname: Grandjean
authors.affiliation: Department of Obstetrics, Gynecology and Reproduction, St-Augustinus Hospital Wilrijk, Oosterveldlaan 24, 2610, Wilrijk, Belgium.
authors.forename: Ben
authors.initials: B
authors.lastname: De Becker
authors.affiliation: Department of Obstetrics and Gynecology, St-Lucas Hospital Bruges, St-Lucaslaan 29, 8310, Bruges, Belgium.
authors.forename: Hilde
authors.initials: H
authors.lastname: Logghe
authors.affiliation: Department of Obstetrics and Gynecology, ZNA Middelheim, Lindendreef 1, 2020, Antwerp, Belgium.
authors.forename: Marc
authors.initials: M
authors.lastname: Coppens
authors.affiliation: Department of Obstetrics and Gynecology, Ghent University Hospital, De Pintelaan 185, 9000, Ghent, Belgium.
authors.forename: Kristien
authors.initials: K
authors.lastname: Roelens
authors.affiliation: Department of Obstetrics and Gynecology, St-Jan Hospital Bruges, Ruddershove 10, 8000, Bruges, Belgium.
authors.forename: Anne
authors.initials: A
authors.lastname: Loccufier
authors.affiliation: Department of Development and Regeneration, KU Leuven, Herestraat 49, 3000, Leuven, Belgium.|Department of Obstetrics and Gynecology, University Hospitals Leuven, Herestraat 49, 3000, Leuven, Belgium.
authors.forename: Johan
authors.initials: J
authors.lastname: Verhaeghe
authors.affiliation: Department of Development and Regeneration, KU Leuven, Herestraat 49, 3000, Leuven, Belgium.|Department of Obstetrics, Gynecology and Reproduction, St-Augustinus Hospital Wilrijk, Oosterveldlaan 24, 2610, Wilrijk, Belgium.|Department of Obstetrics and Gynecology, University Hospitals Leuven, Herestraat 49, 3000, Leuven, Belgium.
authors.forename: Roland
authors.initials: R
authors.lastname: Devlieger
mesh_terms: D000293:Adolescent; D000328:Adult; D050110:Bariatric Surgery; D001942:Breast Feeding; D002985:Clinical Protocols; D004032:Diet / Q000706:statistics & numerical data; D019587:Dietary Supplements / Q000706:statistics & numerical data; D005260:Female; D006801:Humans; D008019:Life Style; D008597:Menstrual Cycle; D008875:Middle Aged; D008895:Milk, Human / Q000737:chemistry; D009765:Obesity / Q000150:complications / Q000503:physiopathology / Q000601:surgery*; D011184:Postoperative Period; D011247:Pregnancy; D011248:Pregnancy Complications / Q000209:etiology*; D011256:Pregnancy Outcome; D057234:Preoperative Period; D011446:Prospective Studies; D043762:Reproductive Behavior / Q000706:statistics & numerical data*; D012725:Sexual Behavior; D055815:Young Adult
keywords: Bariatric surgery; Breast feeding; Contraception; Fertility; Obesity; Pregnancy; Reproduction