title: Impact of increased risk for fetal aneuploidy on maternal mood: a prospective longitudinal study.
abstract: BACKGROUND
  Our goal was to prospectively compare the trajectories of depression symptoms through pregnancy and postpartum between women who received normal prenatal screening results and those whose results indicated an increased risk for fetal aneuploidy.
  
  
  METHODS
  Women completed the Edinburgh Postnatal Depression Scale (EPDS) at 4-week intervals between <26 weeks' gestation and 3 months postpartum. We categorized women into four groups: (i) negative serum screening and ultrasound results (SS(-) /US(-) , n = 103), (ii) positive serum screening/negative ultrasound results (SS(+) /US(-) , n = 42), (iii) negative serum screening/positive ultrasound results (SS(-) /US(+) , n = 19), or (iv) positive serum screening and ultrasound results (SS(+) /US(+) , n = 13), and compared EPDS scores between groups using Poisson regression.
  
  
  RESULTS
  Women who received any positive prenatal screening result had significantly higher EPDS scores during pregnancy than SS(-) /US(-) women (p = 0.002), with SS(-) /US(+) women having the highest scores. During the postpartum, any positive screening test result was only marginally significantly associated with EPDS scores (p = 0.06), but women in the SS(-) /US(+) group had significantly higher scores than women in the SS(-) /US(-) group (p = 0.05).
  
  
  CONCLUSIONS
  Our data suggest that different types of prenatal screening tests may have different effects on women's moods, and that depression symptoms persist for women who have soft markers identified on ultrasound.
authors.affiliation: Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia, Canada.
authors.forename: Dayna L
authors.initials: DL
authors.lastname: Nevay
authors.affiliation: Department of Psychiatry, University of British Columbia, Vancouver, British Columbia, Canada.|Women's Health Research Institute, BC Women's Hospital & Health Centre, Vancouver, British Columbia, Canada.
authors.forename: Catriona
authors.initials: C
authors.lastname: Hippman
authors.affiliation: Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia, Canada.|Department of Psychiatry, University of British Columbia, Vancouver, British Columbia, Canada.
authors.forename: Angela
authors.initials: A
authors.lastname: Inglis
authors.affiliation: Women's Health Research Institute, BC Women's Hospital & Health Centre, Vancouver, British Columbia, Canada.
authors.forename: Arianne
authors.identifier: http://orcid.org/0000-0002-3050-0888
authors.initials: A
authors.lastname: Albert
authors.affiliation: Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia, Canada. jehannine.austin@ubc.ca.|Department of Psychiatry, University of British Columbia, Vancouver, British Columbia, Canada. jehannine.austin@ubc.ca.
authors.forename: Jehannine
authors.initials: J
authors.lastname: Austin
mesh_terms: D000782:Aneuploidy; D019052:Depression, Postpartum / Q000175:diagnosis* / Q000523:psychology; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D009035:Mothers / Q000523:psychology*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000523:psychology*; D011295:Prenatal Care / Q000379:methods; D011446:Prospective Studies; D011569:Psychiatric Status Rating Scales; D018570:Risk Assessment
keywords: Prenatal screening; depression; mood; postpartum; pregnancy; soft markers