title: A convergent approach to side-chain homologated derivatives of 1α,25-dihydroxyergocalciferol.
abstract: As part of our program on search for vitamin D analogs with selective biological properties, such as low or negligible calcemic action, we describe here an efficient and versatile synthetic approach to derivatives of 1α,25-dihydroxyvitamin D2with homologated side-chains and substitution at C24 for biological evaluation.
authors.affiliation: Department of Organic Chemistry, Laboratorio "Ignacio Ribas", University of Santiago de Compostela, Avda Ciencias s/n, 15782 Santiago de Compostela, Spain; Department of Chemistry and Biochemistry, UCIBIO/REQUIMTE, Rua do Campo Alegre 687, 4169-007 Porto, Portugal.
authors.forename: Silvia
authors.initials: S
authors.lastname: Vinhas
authors.affiliation: Department of Organic Chemistry, Laboratorio "Ignacio Ribas", University of Santiago de Compostela, Avda Ciencias s/n, 15782 Santiago de Compostela, Spain.
authors.forename: Socorro
authors.initials: S
authors.lastname: Vázquez
authors.affiliation: Department of Chemistry and Biochemistry, UCIBIO/REQUIMTE, Rua do Campo Alegre 687, 4169-007 Porto, Portugal.
authors.forename: J E
authors.initials: JE
authors.lastname: Rodríguez-Borges
authors.affiliation: Department of Organic Chemistry, Laboratorio "Ignacio Ribas", University of Santiago de Compostela, Avda Ciencias s/n, 15782 Santiago de Compostela, Spain. Electronic address: rita.sigueiro@usc.es.
authors.forename: Rita
authors.initials: R
authors.lastname: Sigüeiro
mesh_terms: D060326:Chemistry Techniques, Synthetic / Q000379:methods*; D004872:Ergocalciferols / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism; D014815:Vitamins / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D004872:Ergocalciferols; D014815:Vitamins; C003564:1,25-dihydroxyergocalciferol
keywords: 1,25-Dihydroxyergocalciferol; Synthesis; Vitamin D(2) side-chain analogs