title: The Virtual Epileptic Patient: Individualized whole-brain models of epilepsy spread.
abstract: Individual variability has clear effects upon the outcome of therapies and treatment approaches. The customization of healthcare options to the individual patient should accordingly improve treatment results. We propose a novel approach to brain interventions based on personalized brain network models derived from non-invasive structural data of individual patients. Along the example of a patient with bitemporal epilepsy, we show step by step how to develop a Virtual Epileptic Patient (VEP) brain model and integrate patient-specific information such as brain connectivity, epileptogenic zone and MRI lesions. Using high-performance computing, we systematically carry out parameter space explorations, fit and validate the brain model against the patient's empirical stereotactic EEG (SEEG) data and demonstrate how to develop novel personalized strategies towards therapy and intervention.
authors.affiliation: Aix Marseille Univ, INSERM, INS, Inst Neurosci Syst, Marseille, France. Electronic address: viktor.jirsa@univ-amu.fr.
authors.forename: V K
authors.initials: VK
authors.lastname: Jirsa
authors.affiliation: Aix Marseille Univ, INSERM, INS, Inst Neurosci Syst, Marseille, France.
authors.forename: T
authors.initials: T
authors.lastname: Proix
authors.affiliation: Aix Marseille Univ, INSERM, INS, Inst Neurosci Syst, Marseille, France.
authors.forename: D
authors.initials: D
authors.lastname: Perdikis
authors.affiliation: Aix Marseille Univ, INSERM, INS, Inst Neurosci Syst, Marseille, France.
authors.forename: M M
authors.initials: MM
authors.lastname: Woodman
authors.affiliation: Aix Marseille Univ, INSERM, INS, Inst Neurosci Syst, Marseille, France.
authors.forename: H
authors.initials: H
authors.lastname: Wang
authors.affiliation: Epilepsy Center, Cleveland Clinic, Cleveland, OH, USA.
authors.forename: J
authors.initials: J
authors.lastname: Gonzalez-Martinez
authors.affiliation: Aix Marseille Univ, INSERM, INS, Inst Neurosci Syst, Marseille, France.
authors.forename: C
authors.initials: C
authors.lastname: Bernard
authors.affiliation: Aix Marseille Univ, INSERM, INS, Inst Neurosci Syst, Marseille, France.
authors.forename: C
authors.initials: C
authors.lastname: Bénar
authors.affiliation: Aix Marseille Univ, CNRS, CRMBM, Marseille, France.
authors.forename: M
authors.initials: M
authors.lastname: Guye
authors.affiliation: Aix Marseille Univ, INSERM, INS, Inst Neurosci Syst, Marseille, France; Epilepsy Center, Cleveland Clinic, Cleveland, OH, USA.
authors.forename: P
authors.initials: P
authors.lastname: Chauvel
authors.affiliation: Aix Marseille Univ, INSERM, INS, Inst Neurosci Syst, Marseille, France; Epileptology Department, and Clinical Neurophysiology Department, Assistance Publique des Hôpitaux de Marseille, Marseille, France.
authors.forename: F
authors.initials: F
authors.lastname: Bartolomei
mesh_terms: D004827:Epilepsy / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008962:Models, Theoretical; D057285:Precision Medicine / Q000379:methods*