title: Effect of multipurpose solutions on in vivo surface wettability of a silicone hydrogel lens.
abstract: OBJECTIVE
  To compare the in vivo surface wettability of silicone hydrogel (SiHy) contact lenses pre-soaked overnight in different multipurpose solutions (MPS) and normal saline.
  
  
  METHODS
  In this double-blinded, randomized and self-controlled study, 36 subjects were fitted with three pairs of contact lenses (senofilcon A) pre-soaked overnight in five different MPS and saline in a randomized order. Each pair of lenses (pre-soaked in two different solutions the night before) were worn for 15min before assessment of pre-lens non-invasive tear break-up time (PL-NITBUT) using the Medmont corneal topographer (video recording). Corneal integrity was assessed using a slit lamp and a resting interval of 20min was allowed between each pair of lenses to ensure post-lens wear corneal integrity.
  
  
  RESULTS
  Thirty subjects completed the study. The median PL-NITBUT ranged from 2.84s to 3.08s with lenses pre-soaked in different MPS, compared to 2.78s with lenses pre-soaked in saline. No significant differences in PL-NITBUT were found among lenses pre-soaked in different solutions (p=0.647).
  
  
  CONCLUSIONS
  In vivo surface wettability, in terms of PL-NITBUT after 15min of lens wear, of senofilcon A contact lenses pre-soaked overnight in different MPS were not significantly different from those pre-soaked in saline.
authors.affiliation: School of Optometry, The Hong Kong Polytechnic University, Hong Kong, China. Electronic address: kklau@polyu.edu.hk.
authors.forename: Jason Ki-Kit
authors.initials: JK
authors.lastname: Lau
authors.affiliation: School of Optometry, The Hong Kong Polytechnic University, Hong Kong, China.
authors.forename: Hoi-Ting
authors.initials: HT
authors.lastname: So
authors.affiliation: School of Optometry, The Hong Kong Polytechnic University, Hong Kong, China.
authors.forename: Tsz-Kit
authors.initials: TK
authors.lastname: Chiang
authors.affiliation: School of Optometry, The Hong Kong Polytechnic University, Hong Kong, China.
authors.forename: Pauline
authors.initials: P
authors.lastname: Cho
mesh_terms: D000328:Adult; D018639:Contact Lens Solutions / Q000737:chemistry*; D003263:Contact Lenses, Hydrophilic; D004311:Double-Blind Method; D004867:Equipment Design; D019544:Equipment Failure Analysis; D005260:Female; D006801:Humans; D020100:Hydrogels / Q000737:chemistry; D008297:Male; D008422:Materials Testing; D017755:Prosthesis Fitting / Q000379:methods*; D020034:Silicone Gels / Q000737:chemistry*; D013666:Tears / Q000737:chemistry*; D017155:Wettability; D014906:Wetting Agents / Q000737:chemistry*
chemical_list: D018639:Contact Lens Solutions; D020100:Hydrogels; D020034:Silicone Gels; D014906:Wetting Agents
keywords: Multipurpose solution; PL-NITBUT; Silicone hydrogel; Wettability