title: Papain-like cysteine proteases as hubs in plant immunity.
abstract: 902 I. 902 II. 903 III. 903 IV. 903 V. 905 VI. 905 VII. 905 906 References 906 SUMMARY: Plants deploy a sophisticated immune system to cope with different microbial pathogens and other invaders. Recent research provides an increasing body of evidence for papain-like cysteine proteases (PLCPs) being central hubs in plant immunity. PLCPs are required for full resistance of plants to various pathogens. At the same time, PLCPs are targeted by secreted pathogen effectors to suppress immune responses. Consequently, they are subject to a co-evolutionary host-pathogen arms race. When activated, PLCPs induce a broad spectrum of defense responses including plant cell death. While the important role of PLCPs in plant immunity has become more evident, it remains largely elusive how these enzymes are activated and which signaling pathways are triggered to orchestrate different downstream responses.
authors.affiliation: Botanical Institute and Center of Excellence on Plant Sciences (CEPLAS), University of Cologne, BioCenter, Zuelpicher Str. 47a, D-50674, Cologne, Germany.
authors.forename: Johana C
authors.initials: JC
authors.lastname: Misas-Villamil
authors.affiliation: The Plant Chemetics Laboratory, Department of Plant Sciences, University of Oxford, South Parks Lane Road, Oxford, OX1 3RB, UK.
authors.forename: Renier A L
authors.initials: RA
authors.lastname: van der Hoorn
authors.affiliation: Botanical Institute and Center of Excellence on Plant Sciences (CEPLAS), University of Cologne, BioCenter, Zuelpicher Str. 47a, D-50674, Cologne, Germany.
authors.forename: Gunther
authors.initials: G
authors.lastname: Doehlemann
mesh_terms: D000222:Adaptation, Physiological; D016923:Cell Death; D054884:Host-Pathogen Interactions / Q000276:immunology; D010206:Papain / Q000737:chemistry / Q000378:metabolism*; D057865:Plant Immunity; D011956:Receptors, Cell Surface / Q000378:metabolism
chemical_list: D011956:Receptors, Cell Surface; D010206:Papain
keywords: apoplast; cysteine proteases; papain-like cysteine proteases (PLCPs); pathogen effectors; plant immune signaling