title: Anti-Diabetic Effect of Portulaca oleracea L. Polysaccharideandits Mechanism in Diabetic Rats.
abstract: Diabetes mellitus (DM) is a metabolic syndrome caused by multiple genetic and environmental factors. Traditional Chinese medicine preparations have shown a comprehensive and function-regulating characteristic. Purslane (Portulaca oleracea L.) is an annual succulent herb. Currently, there have been some related reports on the treatment of diabetes with purslane. The current study was designed to separate and purify the polysaccharide, a systematic study of its physical and chemical properties, antioxidant activity, and anti-diabetic mechanism, in order to provide a theoretical basis for the development of drugs of purslane. A crude water soluble polysaccharide extracted from purslane was named CPOP (crude Portulaca oleracea L. polysaccharide). Effects of CPOP on bodyweight, glucose tolerance test (GTT), fasting blood glucose (FBG), fasting serum insulin (FINS), insulin sensitivity index (ISI), interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), methane dicarboxylic aldehyde (MDA), and superoxygen dehydrogenises (SOD) were investigated. The results indicate that the oral administration of CPOP could significantly increase the body weight and significantly improve the glucose tolerance in diabetic rats. Meanwhile, CPOP could significantly reduce the FBG level, and elevate the FINS level and ISI value in diabetic rats. In addition, CPOP could significantly reduce TNF-α and IL-6 levels in diabetic rats; CPOP could also reduce MDA and SOD activities in the liver tissue of diabetic rats. These results suggest that the anti-diabetic effect of CPOP may be associated with its antioxidant and anti-inflammatory effects.
authors.affiliation: Pharmaceutical College, Jilin Medical University, Jilin 132011, China. baiyu218@163.com.
authors.forename: Yu
authors.initials: Y
authors.lastname: Bai
authors.affiliation: Department of Pharmacy, Changchun Medical College, Changchun 130033, China. zangxueli1980@163.com.
authors.forename: Xueli
authors.initials: X
authors.lastname: Zang
authors.affiliation: Department of Pathology, China-Japan Union Hospital of Jilin University, Changchun 130033, China. jjsmadina@126.com.
authors.forename: Jinshu
authors.initials: J
authors.lastname: Ma
authors.affiliation: College of Pharmacy, Beihua University, Jilin 132013, China. xuguangyu2005@163.com.
authors.forename: Guangyu
authors.initials: G
authors.lastname: Xu
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy* / Q000378:metabolism; D005951:Glucose Tolerance Test; D007004:Hypoglycemic Agents / Q000494:pharmacology*; D007333:Insulin Resistance; D015850:Interleukin-6 / Q000378:metabolism; D008297:Male; D010936:Plant Extracts / Q000494:pharmacology*; D031822:Portulaca / Q000737:chemistry*; D051381:Rats; D017207:Rats, Sprague-Dawley; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
chemical_list: D001786:Blood Glucose; D007004:Hypoglycemic Agents; D015850:Interleukin-6; D010936:Plant Extracts; D014409:Tumor Necrosis Factor-alpha
keywords: anti-diabetic; polysaccharide; purslane