title: Glucose- or insulin resistance-mediated β-cell replication: PKCζ integrates the proliferative signaling.
abstract: Glucose- or insulin resistance-mediated β-cell replication serves as a useful physiological model of β-cell mass expansion to study the pathophysiology of type 2 diabetes. Lakshmipathi et al. (2016) report that PKCζ activation is crucial for compensatory β-cell proliferation induced by glucose stimulation or high-fat diet-feeding.
authors.affiliation: Department of Endocrinology and Metabolism, Graduate School of Medicine, Yokohama-City University, Yokohama, Japan.
authors.forename: Jun
authors.initials: J
authors.lastname: Shirakawa
authors.affiliation: Department of Endocrinology and Metabolism, Graduate School of Medicine, Yokohama-City University, Yokohama, Japan.
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Terauchi
mesh_terms: D000818:Animals; D003924:Diabetes Mellitus, Type 2; D005947:Glucose; D007333:Insulin Resistance; D050417:Insulin-Secreting Cells / Q000166:cytology; D008810:Mice, Inbred C57BL
chemical_list: D005947:Glucose