title: Predictors of outcomes in outpatients with anorexia nervosa - Results from the ANTOP study.
abstract: This study aimed to determine predictors of BMI and recovery for outpatients with anorexia nervosa (AN). Patients were participants of the ANTOP (Anorexia Nervosa Treatment of Out-Patients) trial and randomized to focal psychodynamic therapy (FPT), enhanced cognitive behavior therapy (CBT-E), or optimized treatment as usual (TAU-O). N=169 patients participated in the one-year follow-up (T4). Outcomes were the BMI and global outcome (recovery/partial syndrome/full syndrome) at T4. We examined the following baseline variables as possible predictors: age, BMI, duration of illness, subtype of AN, various axis I diagnoses, quality of life, self-esteem, and psychological characteristics relevant to AN. Linear and logistic regression analyses were conducted to identify the predictors of the BMI and global outcome. The strongest positive predictor for BMI and recovery at T4 was a higher baseline BMI of the patients. Negative predictors for BMI and recovery were a duration of illness >6 years and a lifetime depression diagnosis at baseline. Additionally, higher bodily pain was significantly associated with a lower BMI and self-esteem was a positive predictor for recovery at T4. A higher baseline BMI and shorter illness duration led to a better outcome. Further research is necessary to investigate whether or not AN patients with lifetime depression, higher bodily pain, and lower self-esteem may benefit from specific treatment approaches.
authors.affiliation: Department of General Internal Medicine and Psychosomatics, University of Heidelberg, Germany. Electronic address: beate.wild@med.uni-heidelberg.de.
authors.forename: Beate
authors.initials: B
authors.lastname: Wild
authors.affiliation: Department of General Internal Medicine and Psychosomatics, University of Heidelberg, Germany.
authors.forename: Hans-Christoph
authors.initials: HC
authors.lastname: Friederich
authors.affiliation: Department of Psychosomatic Medicine and Psychotherapy, University of Tübingen, Germany.
authors.forename: Stephan
authors.initials: S
authors.lastname: Zipfel
authors.affiliation: Department of Psychosomatic Medicine and Psychotherapy, University of Tübingen, Germany.
authors.forename: Gaby
authors.initials: G
authors.lastname: Resmark
authors.affiliation: Department of Psychosomatic Medicine and Psychotherapy, University of Tübingen, Germany.
authors.forename: Katrin
authors.initials: K
authors.lastname: Giel
authors.affiliation: Department of Psychosomatic Medicine and Psychotherapy, University of Tübingen, Germany.
authors.forename: Martin
authors.initials: M
authors.lastname: Teufel
authors.affiliation: Department of General Internal Medicine and Psychosomatics, University of Heidelberg, Germany.
authors.forename: Dieter
authors.initials: D
authors.lastname: Schellberg
authors.affiliation: Department of Psychosomatic Medicine and Psychotherapy, University Medical Center Hamburg-Eppendorf, Germany.
authors.forename: Bernd
authors.initials: B
authors.lastname: Löwe
authors.affiliation: Department of Psychosomatic Medicine and Psychotherapy, Medical School Hanover, Germany.
authors.forename: Martina
authors.initials: M
authors.lastname: de Zwaan
authors.affiliation: Department of Psychosomatic Medicine and Psychotherapy, University of Freiburg, Germany.
authors.forename: Almut
authors.initials: A
authors.lastname: Zeeck
authors.affiliation: Department of Psychosomatic Medicine and Psychotherapy, University of Bochum, Germany.
authors.forename: Stephan
authors.initials: S
authors.lastname: Herpertz
authors.affiliation: Department of Psychosomatic Medicine and Psychotherapy, University of Münster, Germany.
authors.forename: Markus
authors.initials: M
authors.lastname: Burgmer
authors.affiliation: Department of Psychosomatic Medicine and Psychotherapy, University of Ulm, Germany.
authors.forename: Jörn
authors.initials: J
authors.lastname: von Wietersheim
authors.affiliation: Department of Psychosomatic Medicine and Psychotherapy, University of Essen, Germany.
authors.forename: Sefik
authors.initials: S
authors.lastname: Tagay
authors.affiliation: Department of Psychosomatic Medicine and Psychotherapy, Technical University of Munich, Munich, Germany.
authors.forename: Andreas
authors.initials: A
authors.lastname: Dinkel
authors.affiliation: Department of General Internal Medicine and Psychosomatics, University of Heidelberg, Germany.
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Herzog
mesh_terms: D000328:Adult; D000553:Ambulatory Care / Q000379:methods / Q000523:psychology; D000856:Anorexia Nervosa / Q000175:diagnosis / Q000523:psychology* / Q000628:therapy*; D015992:Body Mass Index; D015928:Cognitive Behavioral Therapy / Q000379:methods*; D003863:Depression / Q000175:diagnosis / Q000523:psychology / Q000628:therapy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D010045:Outpatients / Q000523:psychology*; D011237:Predictive Value of Tests; D064889:Psychotherapy, Psychodynamic / Q000379:methods*; D011788:Quality of Life / Q000523:psychology; D012649:Self Concept; D016896:Treatment Outcome; D055815:Young Adult
keywords: ANTOP; Anorexia nervosa; BMI; Depression; Duration of disorder; Outcome; Outpatients; Predictors