title: Contact Lens-induced Limbal Stem Cell Deficiency.
abstract: Limbal stem cell deficiency (LSCD) is a pathologic condition caused by the dysfunction and/or destruction of stem cell precursors of the corneal epithelium, typified clinically by corneal conjunctivalization. The purpose of this review is to critically discuss a less well-known cause of limbal stem cell disease: contact lens (CL) wear. A literature search was conducted to include original articles containing patients with CL-induced LSCD. This review describes epidemiology, diagnostic strategies, pathogenesis, differential diagnosis, and treatment modalities for this condition.
authors.affiliation: Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago, Chicago, IL, USA.
authors.forename: Jennifer
authors.initials: J
authors.lastname: Rossen
authors.affiliation: Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago, Chicago, IL, USA.
authors.forename: Alec
authors.initials: A
authors.lastname: Amram
authors.affiliation: Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago, Chicago, IL, USA.
authors.forename: Behrad
authors.initials: B
authors.lastname: Milani
authors.affiliation: Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago, Chicago, IL, USA.
authors.forename: Dongwook
authors.initials: D
authors.lastname: Park
authors.affiliation: Illinois College of Optometry, Illinois Eye Institute, Chicago, IL, USA.
authors.forename: Jennifer
authors.initials: J
authors.lastname: Harthan
authors.affiliation: Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago, Chicago, IL, USA.
authors.forename: Charlotte
authors.initials: C
authors.lastname: Joslin
authors.affiliation: Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago, Chicago, IL, USA.
authors.forename: Timothy
authors.initials: T
authors.lastname: McMahon
authors.affiliation: Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago, Chicago, IL, USA. Electronic address: adjalili@uic.edu.
authors.forename: Ali
authors.initials: A
authors.lastname: Djalilian
mesh_terms: D003261:Contact Lenses / Q000009:adverse effects*; D003316:Corneal Diseases / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology* / Q000628:therapy; D019573:Epithelium, Corneal / Q000473:pathology*; D006801:Humans; D016850:Limbus Corneae / Q000473:pathology*; D033581:Stem Cell Transplantation; D013234:Stem Cells / Q000473:pathology*; D014792:Visual Acuity
keywords: contact lens; corneal conjunctivalization; limbal stem cell deficiency; limbal stem cells