title: Improvement in Severe Mycophenolic Acid-associated Gastrointestinal Symptoms after Changing Enteric-coated Mycophenolate Sodium to Mizoribine in Renal Transplant Recipients: Two Case Reports.
abstract: Clinical results point to a better gastrointestinal tolerability with enteric-coated mycophenolate sodium as compared to mycophenolate mofetil. However, some transplant recipients who are treated with enteric-coated mycophenolate sodium still experience gastrointestinal symptoms. We herein present two cases of renal transplant recipients with severe gastrointestinal symptoms who were switched from enteric-coated mycophenolate sodium to mizoribine, and the symptom reversal effects were evaluated using the Gastrointestinal Symptom Rating Scale. The results of this study showed a significant improvement in severe gastrointestinal symptoms in renal transplant recipients after converting from enteric-coated mycophenolate sodium to mizoribine.
authors.affiliation: Department of Urology, Chao Yang Hospital, China.
authors.forename: Hang
authors.initials: H
authors.lastname: Liu
authors.forename: Yong
authors.initials: Y
authors.lastname: Wang
authors.forename: Baohan
authors.initials: B
authors.lastname: Fan
authors.forename: Liang
authors.initials: L
authors.lastname: Ren
authors.forename: Wei
authors.initials: W
authors.lastname: Wang
authors.forename: Pengxiao
authors.initials: P
authors.lastname: Hu
authors.forename: Xiaodong
authors.initials: X
authors.lastname: Zhang
mesh_terms: D000328:Adult; D005260:Female; D005767:Gastrointestinal Diseases / Q000139:chemically induced*; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D009173:Mycophenolic Acid / Q000009:adverse effects* / Q000627:therapeutic use; D012263:Ribonucleosides / Q000008:administration & dosage / Q000627:therapeutic use*; D013608:Tablets, Enteric-Coated; D066027:Transplant Recipients
chemical_list: D007166:Immunosuppressive Agents; D012263:Ribonucleosides; D013608:Tablets, Enteric-Coated; C010052:mizoribine; D009173:Mycophenolic Acid