title: Acute effects of walking and combined exercise on oxidative stress and vascular function in peripheral artery disease.
abstract: The aim of this study was to compare the effects of a single session of walking and combined exercise on oxidative stress and vascular function in peripheral arterial disease patients. Thirteen patients with peripheral arterial disease underwent two experimental sessions in random order: walking (ten sets of 2-min walking at the speed corresponding to the onset of claudication pain with 2-min interval between sets) and combined exercise (1 × 10 reps in eight resistance exercises plus five-two-minute sets of walking). Before and after the exercise, vascular function (blood flow, leg vascular resistance and blood-flow postreactive hyperaemia) and oxidative stress (malondialdehyde and plasma nitrite levels) were obtained. Blood flow increased similarly after both sessions, whilst leg vascular resistance decreased similarly after both sessions. Plasma nitrite increased only after the combined exercise. Malondialdehyde decreased after both sessions, and the decrease was greater after combined exercise. As a conclusion, a single session of combined exercise improves blood flow and leg vascular resistance similarly to walking session; however, combined exercise promoted better effects on oxidative stress.
authors.affiliation: Exercise Hemodynamic Laboratory, School of Physical Education and Sport, University of São Paulo, São Paulo, Brazil.
authors.forename: Aluísio H R A
authors.initials: AHRA
authors.lastname: Lima
authors.affiliation: Graduate Program in Physical Education, University of Pernambuco and University Federal of Paraiba, Paraiba, Brazil.
authors.forename: Marilia A
authors.initials: MA
authors.lastname: Correia
authors.affiliation: Graduate Program in Physical Education, University of Pernambuco and University Federal of Paraiba, Paraiba, Brazil.
authors.forename: Antônio H G
authors.initials: AHG
authors.lastname: Soares
authors.affiliation: Graduate Program in Physical Education, University of Pernambuco and University Federal of Paraiba, Paraiba, Brazil.
authors.forename: Breno Q
authors.initials: BQ
authors.lastname: Farah
authors.affiliation: Exercise Hemodynamic Laboratory, School of Physical Education and Sport, University of São Paulo, São Paulo, Brazil.
authors.forename: Cláudia L M
authors.initials: CLM
authors.lastname: Forjaz
authors.affiliation: Israel Institute of Education and Research Albert Einstein, Hospital Israelita Albert Einstein, São Paulo, Brazil.
authors.forename: Alexandre S
authors.initials: AS
authors.lastname: Silva
authors.affiliation: Graduate Program in Physical Education, University of Pernambuco and University Federal of Paraiba, Paraiba, Brazil.
authors.forename: Maria S
authors.initials: MS
authors.lastname: Brasileiro-Santos
authors.affiliation: Graduate Program in Physical Education, University of Pernambuco and University Federal of Paraiba, Paraiba, Brazil.
authors.forename: Amilton C
authors.initials: AC
authors.lastname: Santos
authors.affiliation: Israel Institute of Education and Research Albert Einstein, Hospital Israelita Albert Einstein, São Paulo, Brazil.
authors.forename: Raphael M
authors.initials: RM
authors.lastname: Ritti-Dias
mesh_terms: D000368:Aged; D055109:Ankle Brachial Index; D015415:Biomarkers / Q000097:blood; D001794:Blood Pressure; D005260:Female; D006439:Hemodynamics; D006801:Humans; D006940:Hyperemia / Q000503:physiopathology; D007383:Intermittent Claudication / Q000097:blood / Q000175:diagnosis / Q000503:physiopathology / Q000628:therapy*; D035002:Lower Extremity / Q000098:blood supply*; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D008875:Middle Aged; D009573:Nitrites / Q000097:blood; D018384:Oxidative Stress; D058729:Peripheral Arterial Disease / Q000097:blood / Q000175:diagnosis / Q000503:physiopathology / Q000628:therapy*; D055070:Resistance Training / Q000379:methods*; D012307:Risk Factors; D013997:Time Factors; D016896:Treatment Outcome; D014655:Vascular Resistance; D000072797:Walking Speed
chemical_list: D015415:Biomarkers; D009573:Nitrites; D008315:Malondialdehyde
keywords: aerobic exercise; blood flow velocity; endothelial function; intermittent claudication; resistance exercise