title: Recent Advances in Mechanobiology of Osteosarcoma.
abstract: Mechanotransduction is a key process by which cells perceive extracellular mechanical cues/intercellular physical interactions and transform them into intracellular biochemical signals. This physiological process is crucial during bone development and bone remodeling throughout childhood and adult life, whereas several aberrations during this process have emerged as a distinct pathogenic molecular entity in bone maladies and tumor formation. The present review focuses on recent advances regarding the mechanobiology of osteosarcoma, the most common type of bone cancer. Special emphasis is given on the mechano-responsive signal transduction pathways underlying osteosarcoma pathology and on specific mechanosensitive molecules engaged in osteosarcoma development. J. Cell. Biochem. 118: 232-236, 2017. © 2016 Wiley Periodicals, Inc.
authors.affiliation: Department of Biological Chemistry, Medical School, National and Kapodistrian University of Athens, Athens, 11527, Greece.
authors.forename: Christos
authors.initials: C
authors.lastname: Adamopoulos
authors.affiliation: Department of Biological Chemistry, Medical School, National and Kapodistrian University of Athens, Athens, 11527, Greece.
authors.forename: Antonios N
authors.initials: AN
authors.lastname: Gargalionis
authors.affiliation: Department of Biological Chemistry, Medical School, National and Kapodistrian University of Athens, Athens, 11527, Greece.
authors.forename: Christina
authors.initials: C
authors.lastname: Piperi
authors.affiliation: Department of Biological Chemistry, Medical School, National and Kapodistrian University of Athens, Athens, 11527, Greece.
authors.forename: Athanasios G
authors.initials: AG
authors.lastname: Papavassiliou
mesh_terms: D000818:Animals; D001859:Bone Neoplasms / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D040542:Mechanotransduction, Cellular; D012516:Osteosarcoma / Q000378:metabolism* / Q000473:pathology
keywords: CANCER; MECHANOTRANSDUCTION; OSTEOSARCOMA; POLYCYSTIN MECHANOBIOLOGY