title: Perimovement decrease of alpha/beta oscillations in the human nucleus accumbens.
abstract: The human nucleus accumbens is thought to play an important role in guiding future action selection via an evaluation of current action outcomes. Here we provide electrophysiological evidence for a more direct, i.e., online, role during action preparation. We recorded local field potentials from the nucleus accumbens in patients with epilepsy undergoing surgery for deep brain stimulation. We found a consistent decrease in the power of alpha/beta oscillations (10-30 Hz) before and around the time of movements. This perimovement alpha/beta desynchronization was observed in seven of eight patients and was present both before instructed movements in a serial reaction time task as well as before self-paced, deliberate choices in a decision making task. A similar beta decrease over sensorimotor cortex and in the subthalamic nucleus has been directly related to movement preparation and execution. Our results support the idea of a direct role of the human nucleus accumbens in action preparation and execution.
authors.affiliation: Department of Neurology, Otto von Guericke University, Magdeburg, Germany; Department of Behavioral Neurology, Leibniz Institute for Neurobiology, Magdeburg, Germany; max-philipp.stenner@med.ovgu.de.
authors.forename: Max-Philipp
authors.initials: MP
authors.lastname: Stenner
authors.affiliation: Department of Neurology, Otto von Guericke University, Magdeburg, Germany; Department of Behavioral Neurology, Leibniz Institute for Neurobiology, Magdeburg, Germany.
authors.forename: Stefan
authors.initials: S
authors.lastname: Dürschmid
authors.affiliation: Wellcome Trust Centre for Neuroimaging, University College London, London, United Kingdom; Max Planck University College London Centre for Computational Psychiatry and Ageing Research, London, United Kingdom; and.
authors.forename: Robb B
authors.initials: RB
authors.lastname: Rutledge
authors.affiliation: Department of Neurology, Otto von Guericke University, Magdeburg, Germany; Department of Behavioral Neurology, Leibniz Institute for Neurobiology, Magdeburg, Germany.
authors.forename: Tino
authors.initials: T
authors.lastname: Zaehle
authors.affiliation: Department of Neurology, Otto von Guericke University, Magdeburg, Germany.
authors.forename: Friedhelm C
authors.initials: FC
authors.lastname: Schmitt
authors.affiliation: Department of Neurology, Otto von Guericke University, Magdeburg, Germany.
authors.forename: Jörn
authors.initials: J
authors.lastname: Kaufmann
authors.affiliation: Department of Stereotactic Neurosurgery, Otto von Guericke University, Magdeburg, Germany.
authors.forename: Jürgen
authors.initials: J
authors.lastname: Voges
authors.affiliation: Department of Neurology, Otto von Guericke University, Magdeburg, Germany; Department of Behavioral Neurology, Leibniz Institute for Neurobiology, Magdeburg, Germany.
authors.forename: Hans-Jochen
authors.initials: HJ
authors.lastname: Heinze
authors.affiliation: Wellcome Trust Centre for Neuroimaging, University College London, London, United Kingdom; Max Planck University College London Centre for Computational Psychiatry and Ageing Research, London, United Kingdom; and.
authors.forename: Raymond J
authors.initials: RJ
authors.lastname: Dolan
authors.affiliation: Department of Neurology, Otto von Guericke University, Magdeburg, Germany; Department of Behavioral Neurology, Leibniz Institute for Neurobiology, Magdeburg, Germany.
authors.forename: Mircea Ariel
authors.initials: MA
authors.lastname: Schoenfeld
mesh_terms: D000328:Adult; D000513:Alpha Rhythm / Q000502:physiology*; D001611:Beta Rhythm / Q000502:physiology*; D002755:Choice Behavior / Q000502:physiology; D003344:Cortical Synchronization / Q000502:physiology; D046690:Deep Brain Stimulation; D004827:Epilepsy / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000601:surgery / Q000628:therapy; D005260:Female; D005385:Fingers / Q000502:physiology / Q000503:physiopathology; D007839:Functional Laterality; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009043:Motor Activity / Q000502:physiology*; D009068:Movement / Q000502:physiology; D009483:Neuropsychological Tests; D009714:Nucleus Accumbens / Q000000981:diagnostic imaging / Q000502:physiology* / Q000503:physiopathology / Q000601:surgery
keywords: action preparation; beta oscillations; deep brain stimulation; nucleus accumbens