title: Acute Myeloid Leukaemia Following Matched Allogeneic Bone Marrow Transplantation for T-Cell Lymphoblastic Lymphoma.
abstract: It is now commonly acknowledged that cells from some acute leukaemias may bear both myeloid and lymphoid markers at diagnosis, or that relapse following initial treatment may occur, with blast cells phenotypically different from those seen at initial diagnosis. Patients showing evidence of bi-linear disease seem to carry a worse prognosis for cure. Here, a case of T-cell lymphoblastic lymphoma is reported, who relapsed with acute myeloblastic leukaemia, following allogeneic bone marrow transplantation. Early diagnosis of disease with lymphoid and myeloid features is therefore warranted, so that intensive treatment programmes may be offered, in anticipation of permanent cure.
authors.affiliation: a Departments Haematology and Medical Oncology, Royal Marsden Hospital, Downs Road, Sutton, Surrey.
authors.forename: A
authors.initials: A
authors.lastname: Zuiable
authors.affiliation: a Departments Haematology and Medical Oncology, Royal Marsden Hospital, Downs Road, Sutton, Surrey.
authors.forename: J G
authors.initials: JG
authors.lastname: Treleaven
authors.affiliation: a Departments Haematology and Medical Oncology, Royal Marsden Hospital, Downs Road, Sutton, Surrey.
authors.forename: R L
authors.initials: RL
authors.lastname: Powles
authors.affiliation: a Departments Haematology and Medical Oncology, Royal Marsden Hospital, Downs Road, Sutton, Surrey.
authors.forename: H
authors.initials: H
authors.lastname: Aboud
authors.affiliation: a Departments Haematology and Medical Oncology, Royal Marsden Hospital, Downs Road, Sutton, Surrey.
authors.forename: C
authors.initials: C
authors.lastname: Tiley
authors.affiliation: b Department Haematology, Royal Sussex County Hospital, Brighton, UK.
authors.forename: M W
authors.initials: MW
authors.lastname: Kenny
authors.affiliation: a Departments Haematology and Medical Oncology, Royal Marsden Hospital, Downs Road, Sutton, Surrey.
authors.forename: J
authors.initials: J
authors.lastname: Cavenagh
keywords: Acute myeloid leukaemia; acute lymphoid leukaemia; biphenotypic disease; bone marrow transplantation; chemotherapy; leukaemia markers