title: Highly selective determination of amitriptyline using Nafion-AuNPs@branched polyethyleneimine-derived carbon hollow spheres in pharmaceutical drugs and biological fluids.
abstract: In this paper, AuNPs@Polyethyleneimine-derived carbon hollow spheres were synthesized by a versatile and facile method in three steps and successfully developed and validated as Amitriptyline sensor using cyclic voltammetry (CV), chronoamperometry (CA) and differential pulse voltammetry (DPV) methods. The characterization of the electrode surface has been carried out by means of scanning electron microscopy (SEM), transmission electron microscopy (TEM), x-ray diffraction (XRD), x-ray photo-electron spectrum (XPS), electrochemical impedance spectroscopy (EIS) and chronocoulometry (CC). The obtained negatively charged modified electrode was highly selective to Amitriptyline and it was shown a wide linear range from 0.1 to 700μmolL(-1), with a lower detection limit of 0.034μmolL(-1) (n=5, S/N=3), revealing the high-sensitivity properties. The modified electrode is used to achieve the real-time quantitative detection of AMT for biological applications, and satisfactory results are obtained. Due to the advantages of the sensor, its selectivity, sensitivity and stability, it will have a bright future in the field of medical diagnosis.
authors.affiliation: Faculty of Chemistry, Shahid Beheshti University, G. C., P.O. Box 19839-4716, Tehran, Iran.
authors.forename: Zeinab Rezayati
authors.initials: ZR
authors.lastname: Zad
authors.affiliation: Faculty of Chemistry, Shahid Beheshti University, G. C., P.O. Box 19839-4716, Tehran, Iran. Electronic address: ss-hosseiny@cc.sbu.ac.ir.
authors.forename: Saied Saeed Hosseiny
authors.initials: SSH
authors.lastname: Davarani
authors.affiliation: Islamic Azad University - Ilam Branch, Ilam, Iran.
authors.forename: Ali Reza
authors.initials: AR
authors.lastname: Taheri
authors.affiliation: Faculty of Chemistry, Shahid Beheshti University, G. C., P.O. Box 19839-4716, Tehran, Iran.
authors.forename: Yasamin
authors.initials: Y
authors.lastname: Bide
mesh_terms: D000639:Amitriptyline / Q000097:blood*; D003217:Conductometry / Q000295:instrumentation*; D004867:Equipment Design; D019544:Equipment Failure Analysis; D005465:Fluorocarbon Polymers / Q000737:chemistry*; D006046:Gold / Q000737:chemistry; D006801:Humans; D053768:Metal Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D058608:Nanopores / Q000648:ultrastructure; D054118:Nanospheres / Q000737:chemistry* / Q000648:ultrastructure; D037742:Nanotubes, Carbon / Q000737:chemistry* / Q000648:ultrastructure; D011094:Polyethyleneimine / Q000737:chemistry; D016062:Porosity; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity
chemical_list: D005465:Fluorocarbon Polymers; D037742:Nanotubes, Carbon; D000639:Amitriptyline; C040402:perfluorosulfonic acid; D006046:Gold; D011094:Polyethyleneimine
keywords: Amitriptyline; Carbon hollow spheres; Electrochemical sensor; Modified Au electrode; Nafion