title: [Analysis of clinical characteristics and risk of stroke and death within 1 year of patients with nonvalvular atrial fibrillation combined with diabetes mellitus].
abstract: OBJECTIVE
  To explore the clinical characteristics and impact of diabetes mellitus (DM) on prognosis in patients with nonvalvular atrial fibrillation (AF).
  
  
  METHODS
  Data of nonvalvular AF patients in the Chinese Emergency Atrial Fibrillation Registry Study were retrospectively analyzed. The eligible patients were divided into the DM group and the non-DM group. Uni- and multi-variate Cox regression analysis were used to explore risk factors of 1-year outcomes.
  
  
  RESULTS
  A total of 1 644 patients were enrolled in the study with 227 patients combined with DM (16.8%). Compared with non-DM group, patients with DM were older and had higher body weight, had higher prevalence of myocardial infarction, coronary heart disease, hypertension and stroke, and were at higher risk of thromboembolism. The proportion of anticoagulant treatment was low in both groups (10.1% vs 7.4%, P=0.141). Compared with patients without DM, patients with DM had higher all-cause mortality (19.5% vs 12.7%, P=0.004), cardiovascular death (10.8% vs 7.02%, P=0.047) and combined end events (CEE, 26.4% vs 2.4%, P=0.023), while with comparable incidence of stroke (10.1% vs 7.4%, P=0.141). Multi-variate Cox regression analysis showed that DM was an independent risk factor for 1-year all-cause mortality (HR=1.558, 95% CI 1.126-2.156), cardiovascular death (HR=1.615, 95% CI 1.052-2.479) and CEE (HR=1.523, 95% CI 1.098-2.112), while not for stroke (HR=1.523, 95% CI 1.098-2.112).
  
  
  CONCLUSIONS
  DM is the independent risk factor for all-cause mortality, cardiovascular death and combined end events in patients with nonvalvular AF, while not a predictor for the occurrence of stroke.
authors.affiliation: Emergency and Intensive Care Center, Fuwai Hospital, National Center for Cardiovascular Disease, Chinese Academy of Medical Science and Peking Union Medical College, Beijing 100037, China.
authors.forename: S
authors.initials: S
authors.lastname: Wu
authors.forename: Y M
authors.initials: YM
authors.lastname: Yang
authors.forename: J
authors.initials: J
authors.lastname: Zhu
authors.forename: B
authors.initials: B
authors.lastname: Huang
authors.forename: J
authors.initials: J
authors.lastname: Wang
authors.forename: H B
authors.initials: HB
authors.lastname: Wan
authors.forename: H
authors.initials: H
authors.lastname: Zhang
authors.forename: X H
authors.initials: XH
authors.lastname: Shao
mesh_terms: D000925:Anticoagulants; D001281:Atrial Fibrillation; D048909:Diabetes Complications; D003920:Diabetes Mellitus; D006801:Humans; D006973:Hypertension; D015994:Incidence; D009203:Myocardial Infarction; D011379:Prognosis; D012189:Retrospective Studies; D012307:Risk Factors; D020521:Stroke; D013997:Time Factors
chemical_list: D000925:Anticoagulants