title: Meroterpenoids with New Skeletons from Myrtus communis and Structure Revision of Myrtucommulone K.
abstract: Five sesquiterpene-based meroterpenoids with three kinds of new skeletons [1, 2, 3, (+)-4, and (-)-4] were isolated from the leaves of Myrtus communis. Compound 1 featured a new carbon skeleton with an unprecedented octahydrospiro[bicyclo[7.2.0]undecane-2,2'-chromene] tetracyclic ring system, which possessed two preferred conformations detected by variable-temperature NMR spectroscopy experiments. In addition, the structure of reported myrtucommulone K was revised to be compound 3. The plausible biosynthetic pathways of these meroterpenoids and their cytotoxicities are discussed.
authors.affiliation: Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy and ‡JNU-HKUST Joint Laboratory for Neuroscience & Innovative Drug Research, Jinan University , Guangzhou 510632, People's Republic of China.
authors.forename: Chao
authors.initials: C
authors.lastname: Liu
authors.affiliation: Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy and ‡JNU-HKUST Joint Laboratory for Neuroscience & Innovative Drug Research, Jinan University , Guangzhou 510632, People's Republic of China.
authors.forename: Song
authors.initials: S
authors.lastname: Ang
authors.affiliation: Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy and ‡JNU-HKUST Joint Laboratory for Neuroscience & Innovative Drug Research, Jinan University , Guangzhou 510632, People's Republic of China.
authors.forename: Xiao-Jun
authors.initials: XJ
authors.lastname: Huang
authors.affiliation: Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy and ‡JNU-HKUST Joint Laboratory for Neuroscience & Innovative Drug Research, Jinan University , Guangzhou 510632, People's Republic of China.
authors.forename: Hai-Yan
authors.initials: HY
authors.lastname: Tian
authors.affiliation: Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy and ‡JNU-HKUST Joint Laboratory for Neuroscience & Innovative Drug Research, Jinan University , Guangzhou 510632, People's Republic of China.
authors.forename: Yuan-Yuan
authors.initials: YY
authors.lastname: Deng
authors.affiliation: Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy and ‡JNU-HKUST Joint Laboratory for Neuroscience & Innovative Drug Research, Jinan University , Guangzhou 510632, People's Republic of China.
authors.forename: Dong-Mei
authors.initials: DM
authors.lastname: Zhang
authors.affiliation: Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy and ‡JNU-HKUST Joint Laboratory for Neuroscience & Innovative Drug Research, Jinan University , Guangzhou 510632, People's Republic of China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy and ‡JNU-HKUST Joint Laboratory for Neuroscience & Innovative Drug Research, Jinan University , Guangzhou 510632, People's Republic of China.
authors.forename: Wen-Cai
authors.initials: WC
authors.lastname: Ye
authors.affiliation: Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy and ‡JNU-HKUST Joint Laboratory for Neuroscience & Innovative Drug Research, Jinan University , Guangzhou 510632, People's Republic of China.
authors.forename: Lei
authors.initials: L
authors.lastname: Wang
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004354:Drug Screening Assays, Antitumor; D056945:Hep G2 Cells; D006801:Humans; D031651:Myrtus / Q000737:chemistry*; D010696:Phloroglucinol / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D018515:Plant Leaves / Q000737:chemistry; D013329:Structure-Activity Relationship; D013729:Terpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D013729:Terpenes; C000627693:myrtucommulone K; D010696:Phloroglucinol