title: Does smoking, age or gender affect the protein phenotype of extracellular vesicles in plasma?
abstract: Extracellular vesicles (EVs) are involved in several diseases, which have formed the basis for the potential use of EV analyses in a clinical setting. The protein phenotype of EVs can provide information on the functionality of the vesicles and may be used for identification of disease-related biomarkers. With this extensive study of 161 healthy individuals it was elucidated that certain markers of plasma EVs are influenced by demographic variations such as gender, age and smoking status. When the purpose is to use EVs as a diagnostic tool, it should be emphasized how important it is to choose the correct demographic group when comparing marker levels of plasma EVs.
authors.affiliation: Department of Clinical Immunology, Aalborg University Hospital, DK-9000 Aalborg, Denmark.
authors.forename: R
authors.initials: R
authors.lastname: Bæk
authors.affiliation: Department of Clinical Immunology, Aalborg University Hospital, DK-9000 Aalborg, Denmark.
authors.forename: K
authors.initials: K
authors.lastname: Varming
authors.affiliation: Department of Clinical Immunology, Aalborg University Hospital, DK-9000 Aalborg, Denmark. Electronic address: maljoe@rn.dk.
authors.forename: M M
authors.initials: MM
authors.lastname: Jørgensen
mesh_terms: D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D055252:Cell-Derived Microparticles / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D008565:Membrane Proteins / Q000097:blood*; D008875:Middle Aged; D012727:Sex Characteristics; D012907:Smoking / Q000097:blood*
chemical_list: D015415:Biomarkers; D008565:Membrane Proteins
keywords: Aging; Extracellular vesicles in plasma; Gender; Phenotyping; Smoking