title: Regenerated cellulose/wool blend enhanced biomimetic hydroxyapatite mineralization.
abstract: The current article investigates the effect of bioactive cellulose/wool blend on calcium phosphate biomimetic mineralization. Regenerated cellulose/wool blend was prepared by dissolution-regeneration of neat cellulose and natural wool in 1-butyl-3-methyl imidazolium chloride [Bmim][Cl], as a solvent for the two polymers. Crystalline hydroxyapatite nanofibers with a uniform size, shape and dimension were formed after immersing the bioactive blend in simulated body fluid. The cytotoxicity of cellulose/wool/hydroxyapatite was studied using animal fibroblast baby hamster kidney cells (BHK-21) and the result displayed good cytocompatability. This research work presents a green processing method for the development of novel cellulose/wool/hydroxyapatite hybrid materials for tissue engineering applications.
authors.affiliation: Cellulose and Paper Department, National Research Centre, 33 El-Bohouth st., Dokki, P.O. 12622, Giza, Egypt. Electronic address: Ahmed_nigm78@yahoo.com.
authors.forename: Ahmed
authors.initials: A
authors.lastname: Salama
authors.affiliation: Cellulose and Paper Department, National Research Centre, 33 El-Bohouth st., Dokki, P.O. 12622, Giza, Egypt.
authors.forename: Mohamed
authors.initials: M
authors.lastname: El-Sakhawy
mesh_terms: D000818:Animals; D040761:Biomimetic Materials / Q000494:pharmacology*; D016923:Cell Death / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D002482:Cellulose / Q000494:pharmacology*; D006224:Cricetinae; D017886:Durapatite / Q000494:pharmacology*; D008903:Minerals / Q000494:pharmacology*; D012756:Sheep; D017550:Spectroscopy, Fourier Transform Infrared; D013499:Surface Properties; D013818:Thermogravimetry; D014935:Wool / Q000737:chemistry*; D014961:X-Ray Diffraction
chemical_list: D008903:Minerals; D002482:Cellulose; D017886:Durapatite
keywords: Calcium phosphate; Cellulose; Ionic liquid; Mineralization; Wool