title: Release studies of trans-anethole from β-cyclodextrin solid inclusion complexes by Multiple Headspace Extraction.
abstract: This study aimed to evaluate the effect of the preparation method, temperature and humidity on the release of aroma from β-cyclodextrin (β-CD) solid inclusion complexes (IC). Therefore β-CD/trans-anethole (β-CD/AN) IC were prepared by freeze-drying (FD) and co-precipitation coupled to FD (Cop-FD). Release experiments were performed at various temperatures and relative humidities (RH). Multiple headspace extraction-gas chromatography (MHE) was used to determine the loading capacity (LC) and encapsulation efficiency (EE%) and perform release studies. Results underlined that the quantification of encapsulated AN by MHE requires the IC dissolution. The release of AN was accelerated by increases in RH and temperature. However, it was quite negligible below 75% RH. The release behavior of AN was well simulated by Avrami's equation. Cop-FD IC retained more efficiently AN and the release depended on the preparation method and treatment conditions. Thus, the preparation method could be chosen based on the application.
authors.affiliation: Unité de Chimie Environnementale et Interactions sur le Vivant (UCEIV, EA 4492), SFR Condorcet FR CNRS 3417, ULCO, F-59140 Dunkerque, France; Bioactive Molecules Research Group, Faculty of Sciences-2, Lebanese University, Fanar, Lebanon.
authors.forename: Miriana
authors.initials: M
authors.lastname: Kfoury
authors.affiliation: Bioactive Molecules Research Group, Faculty of Sciences-2, Lebanese University, Fanar, Lebanon.
authors.forename: Lizette
authors.initials: L
authors.lastname: Auezova
authors.affiliation: Bioactive Molecules Research Group, Faculty of Sciences-2, Lebanese University, Fanar, Lebanon.
authors.forename: Hélène
authors.initials: H
authors.lastname: Greige-Gerges
authors.affiliation: Section of Chemistry, Department of Chemistry and Bioscience, Aalborg University, Fredrik Bajers Vej 7H, DK-9220 Aalborg East, Denmark.
authors.forename: Kim L
authors.initials: KL
authors.lastname: Larsen
authors.affiliation: Unité de Chimie Environnementale et Interactions sur le Vivant (UCEIV, EA 4492), SFR Condorcet FR CNRS 3417, ULCO, F-59140 Dunkerque, France. Electronic address: lamotte@univ-littoral.fr.
authors.forename: Sophie
authors.initials: S
authors.lastname: Fourmentin
mesh_terms: D000081248:Allylbenzene Derivatives; D000840:Anisoles / Q000737:chemistry*; D011232:Chemical Precipitation; D005612:Freeze Drying; D006813:Humidity; D007700:Kinetics; D013696:Temperature; D047392:beta-Cyclodextrins / Q000737:chemistry*
chemical_list: D000081248:Allylbenzene Derivatives; D000840:Anisoles; D047392:beta-Cyclodextrins; C006578:anethole
keywords: Controlled release; Inclusion complexes; Multiple headspace extraction; Relative humidity; Temperature; β-Cyclodextrin