title: Short-term moderate diet restriction in adulthood can reverse oxidative, cardiovascular and metabolic alterations induced by postnatal overfeeding in mice.
abstract: We aimed to determine whether moderate diet restriction could restore cardiac, oxidative and metabolic alterations induced by postnatal overfeeding (PNOF). Litters of C57BL/6 male mice were either maintained at 9 (normal litter, NL), or reduced to 3 (small litter, SL) in order to induce PNOF. At 6 months, half of the NL and SL mice were subjected to 20% calorie-restriction (CR: NLCR, SLCR) for one month, while the other half continued to eat ad libitum (AL: NLAL, SLAL). Six-month old SL mice presented overweight, fat accumulation, hyperleptinemia, glucose intolerance, insulin resistance, increased cardiac ROS production and decreased left ventricular ejection fraction (LVEF). After CR, SL mice body weight was normalized; however, their fat mass and leptinemia were not decreased, glucose metabolism was improved and LVEF was increased. In SL mice, CR increased the cardiac mitochondrial respiratory rate and decreased cardiac ROS production. Hearts from SLCR mice showed better recovery and smaller postischemic infarct size. Intriguingly, no difference was observed between NLAL and NLCR mice for most of the parameters investigated. Short-term moderate CR not only normalized body weight in SL mice but also improved metabolic programming and reversed oxidative and cardiac dysfunction induced by PNOF.
authors.affiliation: Inserm UMR866, Laboratoire de Physiopathologie et Pharmacologie Cardio-Métaboliques (LPPCM), Université de Bourgogne Franche-Comté, Dijon, France.
authors.forename: Na
authors.initials: N
authors.lastname: Li
authors.affiliation: Inserm UMR866, Laboratoire de Physiopathologie et Pharmacologie Cardio-Métaboliques (LPPCM), Université de Bourgogne Franche-Comté, Dijon, France.|Service de Cardiologie, Centre Hospitalier Universitaire, Dijon, France.
authors.forename: Charles
authors.initials: C
authors.lastname: Guenancia
authors.affiliation: Inserm UMR866, Laboratoire de Physiopathologie et Pharmacologie Cardio-Métaboliques (LPPCM), Université de Bourgogne Franche-Comté, Dijon, France.
authors.forename: Eve
authors.initials: E
authors.lastname: Rigal
authors.affiliation: Inserm UMR866, Laboratoire de Physiopathologie et Pharmacologie Cardio-Métaboliques (LPPCM), Université de Bourgogne Franche-Comté, Dijon, France.
authors.forename: Olivier
authors.initials: O
authors.lastname: Hachet
authors.affiliation: Inserm UMR866, Laboratoire de Physiopathologie et Pharmacologie Cardio-Métaboliques (LPPCM), Université de Bourgogne Franche-Comté, Dijon, France.
authors.forename: Pauline
authors.initials: P
authors.lastname: Chollet
authors.affiliation: CNRS UMR 6265, Centre des Sciences du Goût de l'Alimentation, Dijon, France.|INRA UMR 1324, Centre des Sciences du Goût de l'Alimentation, Dijon, France.|Univ. Bourgogne Franche-Comté, UMR Centre des Sciences du Goût de l'Alimentation Dijon, France.
authors.forename: Lucie
authors.initials: L
authors.lastname: Desmoulins
authors.affiliation: CNRS UMR 6265, Centre des Sciences du Goût de l'Alimentation, Dijon, France.|INRA UMR 1324, Centre des Sciences du Goût de l'Alimentation, Dijon, France.|Univ. Bourgogne Franche-Comté, UMR Centre des Sciences du Goût de l'Alimentation Dijon, France.
authors.forename: Corinne
authors.initials: C
authors.lastname: Leloup
authors.affiliation: Inserm UMR866, Laboratoire de Physiopathologie et Pharmacologie Cardio-Métaboliques (LPPCM), Université de Bourgogne Franche-Comté, Dijon, France.
authors.forename: Luc
authors.initials: L
authors.lastname: Rochette
authors.affiliation: Inserm UMR866, Laboratoire de Physiopathologie et Pharmacologie Cardio-Métaboliques (LPPCM), Université de Bourgogne Franche-Comté, Dijon, France.
authors.forename: Catherine
authors.initials: C
authors.lastname: Vergely
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D001823:Body Composition; D001835:Body Weight; D031204:Caloric Restriction / Q000379:methods*; D007333:Insulin Resistance; D008098:Litter Size; D008297:Male; D008659:Metabolic Diseases / Q000178:diet therapy*; D051379:Mice; D008810:Mice, Inbred C57BL; D008929:Mitochondria, Heart / Q000187:drug effects / Q000502:physiology*; D018384:Oxidative Stress / Q000187:drug effects