title: Impact of di-(2-ethylhexyl) phthalate on the uterus of adult Wistar rats.
abstract: Di-(2-ethylhexyl) phthalate (DEHP) is the most common plasticizer used in polyvinyl chloride-based plastics. DEHP is not covalently bound to the plastics and is easily released to the environment, resulting in human exposure. In this study, the adult rats were exposed to DEHP and its effects on the uterus was evaluated. Healthy adult female rats were treated with DEHP orally (with dose level 0, 1, 10, and 100 mg/kg body weight/day) for 30 days. No significant changes in the body weight and wet uterine weight were observed. Ovarian hormones and their receptor levels in the uterus were increased. Histological studies exhibited the structural abnormalities such as decrease in diameter, thinning of the layers and disruption in the glandular epithelium.
authors.affiliation: 1 Department of Endocrinology, University of Madras, Institute of Basic Medical Sciences.
authors.forename: D B
authors.initials: DB
authors.lastname: Somasundaram
authors.affiliation: 2 School of Allied Health Sciences, Manipal University, Manipal, Karnataka, India.
authors.forename: K
authors.initials: K
authors.lastname: Manokaran
authors.affiliation: 1 Department of Endocrinology, University of Madras, Institute of Basic Medical Sciences.
authors.forename: B C
authors.initials: BC
authors.lastname: Selvanesan
authors.affiliation: 1 Department of Endocrinology, University of Madras, Institute of Basic Medical Sciences.
authors.forename: R S
authors.initials: RS
authors.lastname: Bhaskaran
mesh_terms: D000818:Animals; D001835:Body Weight / Q000187:drug effects; D004051:Diethylhexyl Phthalate / Q000633:toxicity*; D004958:Estradiol / Q000097:blood; D047628:Estrogen Receptor alpha / Q000235:genetics / Q000378:metabolism; D047629:Estrogen Receptor beta / Q000235:genetics / Q000378:metabolism; D005260:Female; D009929:Organ Size / Q000187:drug effects; D047495:PPAR gamma / Q000235:genetics / Q000378:metabolism; D010968:Plasticizers / Q000633:toxicity*; D011374:Progesterone / Q000097:blood; D012333:RNA, Messenger / Q000378:metabolism; D017208:Rats, Wistar; D011980:Receptors, Progesterone / Q000235:genetics / Q000378:metabolism; D014599:Uterus / Q000187:drug effects* / Q000473:pathology
chemical_list: D047628:Estrogen Receptor alpha; D047629:Estrogen Receptor beta; D047495:PPAR gamma; D010968:Plasticizers; D012333:RNA, Messenger; D011980:Receptors, Progesterone; D011374:Progesterone; D004958:Estradiol; D004051:Diethylhexyl Phthalate
keywords: DEHP; PPAR; estrogen receptors; progesterone receptors; uterus