title: The prognostic significance of serum TGF-β1 levels in patients with Crimean-Congo hemorrhagic fever.
abstract: Crimean-Congo Hemorrhagic Fever (CCHF) may exhibit a mild clinical course or a severe profile like mortal bleeding. The pathogenesis of the illness and reason of bleeding are unclear. However, endothelial injury is a key factor in the pathogenesis of the illness. Transforming growth factor beta (TGF-β) is one of the materials involved in repairing injured endothelium. This is a significant polypeptide released in pretty much all cells and important for the regulation of cellular events, epithelium formation, inflammation, blood coagulation, and collagen synthesis. This study aimed to determine the prognostic significance of serum TGF-β1 levels in CCHF patients. We examined 120 patients hospitalized with CCHF diagnosis and their serum TGF-β1 was investigated, retrospectively. Patients were put into two groups according to the existence of hemorrhage. Forty-four (36.7%) patients had hemorrhage. TGF-β1 levels in patients with bleeding were 5.2 ± 1.8, and 7.1 ± 2.2 for non-bleeding (P < 0.0001). When ROC analysis was performed in patients with CCHF alone in order to identify patients with bleeding, at a TGF-β1 cut-off point of 4.9, AUC was 0.762 (0.675-0.835), sensitivity 59.1%, specificity 85.5%, PPV 70.3%, and NPV 78.3%. We summarize that TGF-β1 level and endothelial dysfunction can be related. A decreased TGF-β1 level is a likely prognostic and diagnostic factor for bleeding in CCHF patients. Therefore, this marker should be considered in the treatment strategy for these patients. J. Med. Virol. 89:413-416, 2017. © 2016 Wiley Periodicals, Inc.
authors.affiliation: Department of Infectious Diseases and Clinical Microbiology, Karadeniz Technical University Medical Faculty, Trabzon, Turkey.
authors.forename: Gürdal
authors.initials: G
authors.lastname: Yilmaz
authors.affiliation: Department of Medical Biochemistry, Kanuni Training and Research Hospital, Trabzon, Turkey.
authors.forename: Hülya
authors.initials: H
authors.lastname: Yilmaz
authors.affiliation: Department of Infectious Diseases and Clinical Microbiology, Amasya University Sabuncuoglu Serefeddin Training and Research Hospital, Amasya, Turkey.
authors.forename: Mustafa
authors.initials: M
authors.lastname: Arslan
authors.affiliation: Department of Infectious Diseases and Clinical Microbiology, 4Recep Tayyip Erdogan University Medical Faculty, Rize, Turkey.
authors.forename: Uğur
authors.initials: U
authors.lastname: Kostakoğlu
authors.affiliation: Department of Medical Biochemistry, Karadeniz Technical University Medical Faculty, Trabzon, Turkey.
authors.forename: Ahmet
authors.initials: A
authors.lastname: Menteşe
authors.affiliation: Department of Medical Biochemistry, Karadeniz Technical University Medical Faculty, Trabzon, Turkey.
authors.forename: Süleyman Caner
authors.initials: SC
authors.lastname: Karahan
authors.affiliation: Department of Infectious Diseases and Clinical Microbiology, Karadeniz Technical University Medical Faculty, Trabzon, Turkey.
authors.forename: İftihar
authors.initials: İ
authors.lastname: Köksal
mesh_terms: D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood*; D003955:Diagnostic Tests, Routine / Q000379:methods*; D005260:Female; D006470:Hemorrhage / Q000175:diagnosis* / Q000473:pathology; D006479:Hemorrhagic Fever, Crimean / Q000175:diagnosis* / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012372:ROC Curve; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D044967:Serum / Q000737:chemistry*; D053773:Transforming Growth Factor beta1 / Q000097:blood*
chemical_list: D015415:Biomarkers; D053773:Transforming Growth Factor beta1
keywords: CCHF; Crimean-Congo hemorrhagic fever; TGF-β1