title: Aberrant post-translational protein modifications in the pathogenesis of alcohol-induced liver injury.
abstract: It is likely that the majority of proteins will undergo post-translational modification, be it enzymatic or non-enzymatic. These modified protein(s) regulate activity, localization and interaction with other cellular molecules thereby maintaining cellular hemostasis. Alcohol exposure significantly alters several of these post-translational modifications leading to impairments of many essential physiological processes. Here, we present new insights into novel modifications following ethanol exposure and their role in the initiation and progression of liver injury. This critical review condenses the proceedings of a symposium at the European Society for the Biomedical Research on Alcoholism Meeting held September 12-15, 2015, in Valencia, Spain.
authors.affiliation: Natalia A Osna, Murali Ganesan, Kusum K Kharbanda, Research Service, Veterans Affairs Nebraska-Western Iowa Health Care System, Omaha, NE 68105, United States.
authors.forename: Natalia A
authors.initials: NA
authors.lastname: Osna
authors.affiliation: Natalia A Osna, Murali Ganesan, Kusum K Kharbanda, Research Service, Veterans Affairs Nebraska-Western Iowa Health Care System, Omaha, NE 68105, United States.
authors.forename: Wayne G
authors.initials: WG
authors.lastname: Carter
authors.affiliation: Natalia A Osna, Murali Ganesan, Kusum K Kharbanda, Research Service, Veterans Affairs Nebraska-Western Iowa Health Care System, Omaha, NE 68105, United States.
authors.forename: Murali
authors.initials: M
authors.lastname: Ganesan
authors.affiliation: Natalia A Osna, Murali Ganesan, Kusum K Kharbanda, Research Service, Veterans Affairs Nebraska-Western Iowa Health Care System, Omaha, NE 68105, United States.
authors.forename: Irina A
authors.initials: IA
authors.lastname: Kirpich
authors.affiliation: Natalia A Osna, Murali Ganesan, Kusum K Kharbanda, Research Service, Veterans Affairs Nebraska-Western Iowa Health Care System, Omaha, NE 68105, United States.
authors.forename: Craig J
authors.initials: CJ
authors.lastname: McClain
authors.affiliation: Natalia A Osna, Murali Ganesan, Kusum K Kharbanda, Research Service, Veterans Affairs Nebraska-Western Iowa Health Care System, Omaha, NE 68105, United States.
authors.forename: Dennis R
authors.initials: DR
authors.lastname: Petersen
authors.affiliation: Natalia A Osna, Murali Ganesan, Kusum K Kharbanda, Research Service, Veterans Affairs Nebraska-Western Iowa Health Care System, Omaha, NE 68105, United States.
authors.forename: Colin T
authors.initials: CT
authors.lastname: Shearn
authors.affiliation: Natalia A Osna, Murali Ganesan, Kusum K Kharbanda, Research Service, Veterans Affairs Nebraska-Western Iowa Health Care System, Omaha, NE 68105, United States.
authors.forename: Maria L
authors.initials: ML
authors.lastname: Tomasi
authors.affiliation: Natalia A Osna, Murali Ganesan, Kusum K Kharbanda, Research Service, Veterans Affairs Nebraska-Western Iowa Health Care System, Omaha, NE 68105, United States.
authors.forename: Kusum K
authors.initials: KK
authors.lastname: Kharbanda
mesh_terms: D000107:Acetylation; D005227:Fatty Acids / Q000378:metabolism; D006031:Glycosylation; D006801:Humans; D008108:Liver Diseases, Alcoholic / Q000378:metabolism*; D008745:Methylation; D010087:Oxides / Q000378:metabolism; D050050:Protein Carbonylation; D026601:Protein D-Aspartate-L-Isoaspartate Methyltransferase / Q000378:metabolism; D011499:Protein Processing, Post-Translational; D058207:Sumoylation
chemical_list: D005227:Fatty Acids; D010087:Oxides; D026601:Protein D-Aspartate-L-Isoaspartate Methyltransferase
keywords: Acetylation; Alcohol; Betaine; Carbonylation methylation; Dysfunction; Glycosylation; Liver; Methylation; Phosphorylation; Post-translational protein modification; Sumoylation; Ubiquitination