title: Protective effect of ayurvedic formulations against doxorubicin-induced cardiotoxicity: Preliminary studies on Brahma Rasayana and Chyavanaprash.
abstract: OBJECTIVE
  The present work aimed to examine the efficacy of two ayurvedic formulations, Brahma Rasayana (BRM) and Chyavanaprash (CHM) to alleviate doxorubicin (DOX) induced acute cardiotoxicity.
  
  
  METHODS
  Swiss albino mice were administered with DOX (25 mg/kg, i.p.) and two doses of BRM or CHM (1 and 2 g/kg). Cardiotoxicity was assessed by measuring the levels of various antioxidant parameters in the heart as well as release of marker enzymes in the serum was assayed. Histology of the heart was also performed to check for DOX-induced damages.
  
  
  RESULTS
  Administration of either BRM or CHM (1 and 2 g/kg) maintained the antioxidant status in the heart thereby preventing tissue damage as well as the release of marker enzymes. DOX-induced variation of cardiac architecture was also prevented by BRM and CHM administration.
  
  
  CONCLUSIONS
  BRM and CHM administration could prevent DOX-induced acute cardiotoxicity.
authors.affiliation: Department of Genetics, College of Science, King Saud University, Riyadh, Saudi Arabia.
authors.forename: Entissar
authors.initials: E
authors.lastname: AlSuhailbani
authors.affiliation: Pushpagiri Institute of Medical Sciences and Research Centre, Thiruvalla, Kerala, India.
authors.forename: Aditya
authors.initials: A
authors.lastname: Menon
authors.affiliation: Pushpagiri Institute of Medical Sciences and Research Centre, Thiruvalla, Kerala, India.
authors.forename: Cherupally Krishnan Krishnan
authors.initials: CK
authors.lastname: Nair
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000378:metabolism; D066126:Cardiotoxicity / Q000517:prevention & control; D004317:Doxorubicin / Q000633:toxicity*; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D008515:Medicine, Ayurvedic; D051379:Mice; D009206:Myocardium / Q000473:pathology; D010936:Plant Extracts / Q000494:pharmacology*; D028321:Plant Preparations / Q000494:pharmacology*
chemical_list: D000975:Antioxidants; C518324:Chyavanprash; D010936:Plant Extracts; D028321:Plant Preparations; C403274:brahma rasayana; D004317:Doxorubicin