title: Endoscopic Ultrasound-Guided Radiofrequency Ablation of the Pancreatic Tumors: A Promising Tool in Management of Pancreatic Tumors.
abstract: Objective. Radiofrequency ablation is a well-established antitumor treatment and is recognized as one of the least invasive therapeutic modalities for pancreatic neoplasm. Endoscopic ultrasound-guided radiofrequency ablation (EUS-RFA) delivery can be used to treat both pancreatic cancer and asymptomatic premalignant pancreatic neoplasms and may serve as a less invasive alternative to surgical resection. This is an appealing option that may result in less morbidity and mortality. The aim of this review was to summarize and evaluate the clinical and technical effectiveness of EUS-guided RFA of pancreatic neoplasms. Methods. A through literature review was performed to identify the studies describing this novel technique. In this review article, we have summarized human case series. The indications, techniques, limitations, and complications reported are discussed. Results. A total of six studies were included. Overall, a 100% technical success rate was reported in human studies. Complications related to endoscopic ultrasound-guided radiofrequency ablation delivery have been described; however, few cases have presented life-threatening outcomes. Conclusion. We believe that this novel technique can be a safe and effective alternative approach in the management of selected patients.
authors.affiliation: Department of Gastroenterology, The Brooklyn Hospital Center-Clinical Affiliate of Mount Sinai Hospital, Brooklyn, NY 11201, USA.
authors.forename: Kinesh
authors.identifier: 0000-0001-9139-8736
authors.initials: K
authors.lastname: Changela
authors.affiliation: Department of Internal Medicine, Mount Sinai West, New York, NY, USA.
authors.forename: Rashmee
authors.identifier: 0000-0002-8345-0263
authors.initials: R
authors.lastname: Patil
authors.affiliation: Department of Gastroenterology, The Brooklyn Hospital Center-Clinical Affiliate of Mount Sinai Hospital, Brooklyn, NY 11201, USA.
authors.forename: Sushil
authors.identifier: 0000-0003-1364-4414
authors.initials: S
authors.lastname: Duddempudi
authors.affiliation: Department of Gastroenterology, St. Barnabas Hospital, Bronx, NY, USA.
authors.forename: Vinaya
authors.identifier: 0000-0002-3789-5392
authors.initials: V
authors.lastname: Gaduputi
mesh_terms: D017115:Catheter Ablation / Q000379:methods*; D019160:Endosonography; D006801:Humans; D010190:Pancreatic Neoplasms / Q000000981:diagnostic imaging / Q000601:surgery*; D018084:Ultrasonography, Interventional