title: Gender differences and bleeding complications after PCI on first and second generation DES.
abstract: BACKGROUND
  The aim of this study was to evaluate gender differences in the long-term clinical outcomes and safety of patients treated with first- and second generation DES.
  
  
  METHODS
  The Katowice-Zabrze Registry included 1916 consecutive patients treated with either first or second generation DES. We evaluated major adverse cardiac and cerebrovascular events (MACCE) [composite of death, myocardial infarction (MI), stroke and target vessel revascularization (TVR)] at 12-month follow-up. Safety end point was bleeding complications and stent thrombosis.
  
  
  RESULTS
  Registry included [unstable angina (UA) 1500(78%), non-ST-segment elevation myocardial infarction (NSTEMI) 285 (15%), ST-segment elevation myocardial infarction/left bundle branch block (STEMI/LBBB) 131 (7%)]. There were 35.5% females and 64.5% males. Women were older and had higher prevalence of comorbidities. Males more often had multivessel disease and higher Syntax score when comparable to females. We did not observed difference in acute and subacute stent thrombosis in our data, however, females had more in-hospital bleeding complications. Univariable Cox regression analysis revealed that women had similar outcomes when compared to men in terms of a risk of death, MI, TVR, stroke and MACCE at 1-year follow-up. There were no differences between males and females in MACCE when first- and second generation DES were analyzed separately.
  
  
  CONCLUSIONS
  Despite higher risk profile, women treated with DES have similar outcomes as males in 1-year follow-up. However there is, an increased risk of in-hospital bleedings in women.
authors.affiliation: a Third Division of Cardiology , Medical University of Silesia , Katowice , Poland.
authors.forename: Wojciech
authors.initials: W
authors.lastname: Wanha
authors.affiliation: b Division of Cardiology , Medical University of Silesia , Zabrze , Poland.
authors.forename: Damian
authors.initials: D
authors.lastname: Kawecki
authors.affiliation: a Third Division of Cardiology , Medical University of Silesia , Katowice , Poland.
authors.forename: Tomasz
authors.initials: T
authors.lastname: Roleder
authors.affiliation: a Third Division of Cardiology , Medical University of Silesia , Katowice , Poland.
authors.forename: Aleksandra
authors.initials: A
authors.lastname: Pluta
authors.affiliation: a Third Division of Cardiology , Medical University of Silesia , Katowice , Poland.
authors.forename: Kamil
authors.initials: K
authors.lastname: Marcinkiewicz
authors.affiliation: b Division of Cardiology , Medical University of Silesia , Zabrze , Poland.
authors.forename: Beata
authors.initials: B
authors.lastname: Morawiec
authors.affiliation: c Department of Cardiology , Specialistic Hospital , Tarnow , Poland.
authors.forename: Mariusz
authors.initials: M
authors.lastname: Kret
authors.affiliation: a Third Division of Cardiology , Medical University of Silesia , Katowice , Poland.
authors.forename: Tomasz
authors.initials: T
authors.lastname: Pawlowski
authors.affiliation: a Third Division of Cardiology , Medical University of Silesia , Katowice , Poland.
authors.forename: Grzegorz
authors.initials: G
authors.lastname: Smolka
authors.affiliation: a Third Division of Cardiology , Medical University of Silesia , Katowice , Poland.
authors.forename: Andrzej
authors.initials: A
authors.lastname: Ochala
authors.affiliation: a Third Division of Cardiology , Medical University of Silesia , Katowice , Poland.
authors.forename: Wojciech
authors.initials: W
authors.lastname: Wojakowski
mesh_terms: D000789:Angina, Unstable / Q000175:diagnosis / Q000401:mortality / Q000628:therapy*; D001803:Blood Transfusion; D016009:Chi-Square Distribution; D015897:Comorbidity; D054855:Drug-Eluting Stents; D005260:Female; D006470:Hemorrhage / Q000209:etiology* / Q000401:mortality / Q000628:therapy; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D000072658:Non-ST Elevated Myocardial Infarction / Q000175:diagnosis / Q000401:mortality / Q000628:therapy*; D062645:Percutaneous Coronary Intervention / Q000009:adverse effects* / Q000295:instrumentation* / Q000401:mortality; D011044:Poland; D016016:Proportional Hazards Models; D011474:Prosthesis Design; D012042:Registries; D012189:Retrospective Studies; D018570:Risk Assessment; D012307:Risk Factors; D000072657:ST Elevation Myocardial Infarction / Q000175:diagnosis / Q000401:mortality / Q000628:therapy*; D012737:Sex Factors; D013997:Time Factors; D016896:Treatment Outcome
keywords: Percutaneous coronary intervention; bleeding; drug-eluting stents; gender