title: Spectral Analysis of Chinese Medicinal Herbs Based on Delayed Luminescence.
abstract: Traditional Chinese medicine (TCM) plays a critical role in healthcare; however, it lacks scientific evidence to support the multidimensional therapeutic effects. These effects are based on experience, and, to date, there is no advanced tool to evaluate these experience based effects. In the current study, Chinese herbal materials classified with different cold and heat therapeutic properties, based on Chinese medicine principles, were investigated using spectral distribution, as well as the decay probability distribution based on delayed luminescence (DL). A detection system based on ultraweak biophoton emission was developed to determine the DL decay kinetics of the cold and heat properties of Chinese herbal materials. We constructed a mathematical model to fit the experimental data and characterize the properties of Chinese medicinal herbs with different parameters. The results demonstrated that this method has good reproducibility. Moreover, there is a significant difference (p < 0.05) in the spectral distribution and the decay probability distribution of Chinese herbal materials with cold and heat properties. This approach takes advantage of the comprehensive nature of DL compared with more reductionist approaches and is more consistent with TCM principles, in which the core comprises holistic views.
authors.affiliation: Shandong Medicinal Biotechnology Center, Key Laboratory for Biotech-Drugs, Ministry of Health, Shandong Academy of Medical Sciences, Jinan, Shandong 250062, China.
authors.forename: Jingxiang
authors.identifier: 0000-0002-3981-2271
authors.initials: J
authors.lastname: Pang
authors.affiliation: Shandong Center for Disease Control and Prevention, Jinan, Shandong 250014, China.
authors.forename: Xiaoyan
authors.initials: X
authors.lastname: Zhu
authors.affiliation: Department of Basic Medicine, Shandong University of Traditional Chinese Medicine, Jinan, Shandong 250355, China.
authors.forename: Yanli
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Shandong Academy of Traditional Chinese Medicine, Jinan, Shandong 250014, China.
authors.forename: Jialei
authors.initials: J
authors.lastname: Fu
authors.affiliation: Shandong Medicinal Biotechnology Center, Key Laboratory for Biotech-Drugs, Ministry of Health, Shandong Academy of Medical Sciences, Jinan, Shandong 250062, China.
authors.forename: Xiaolei
authors.initials: X
authors.lastname: Zhao
authors.affiliation: Shandong Medicinal Biotechnology Center, Key Laboratory for Biotech-Drugs, Ministry of Health, Shandong Academy of Medical Sciences, Jinan, Shandong 250062, China.
authors.forename: Meina
authors.identifier: 0000-0002-5149-2194
authors.initials: M
authors.lastname: Yang
authors.affiliation: Sino-Dutch Centre for Preventive and Personalized Medicine/Centre for Photonics of Living Systems, Leiden University, 2300 RA Leiden, Netherlands.
authors.forename: Eduard
authors.initials: E
authors.lastname: van Wijk
authors.affiliation: Sino-Dutch Centre for Preventive and Personalized Medicine/Centre for Photonics of Living Systems, Leiden University, 2300 RA Leiden, Netherlands.
authors.forename: Mei
authors.initials: M
authors.lastname: Wang
authors.affiliation: Shandong Medicinal Biotechnology Center, Key Laboratory for Biotech-Drugs, Ministry of Health, Shandong Academy of Medical Sciences, Jinan, Shandong 250062, China.
authors.forename: Xiaoyan
authors.initials: X
authors.lastname: Nie
authors.affiliation: Shandong Medicinal Biotechnology Center, Key Laboratory for Biotech-Drugs, Ministry of Health, Shandong Academy of Medical Sciences, Jinan, Shandong 250062, China.
authors.forename: Jinxiang
authors.identifier: 0000-0001-9269-4553
authors.initials: J
authors.lastname: Han