title: Development of innovative hybrid and intrinsically magnetic nanobeads as a drug delivery system.
abstract: Synthesis of superparamagnetic hybrid nanobeads (MHNs) made of iron-substituted hydroxyapatite nanophase mineralizing a self-assembling alginate (Alg) matrix to be used as drug carriers, with ability of remote activation by magnetic signaling.
  
  
  
  Iron-doped apatite was heterogeneously nucleated on the self-assembling Alg matrix by a bioinspired mineralization process and MHNs are formed by a subsequent emulsification by oil-in-water technique.
  
  
  
  The obtained MHNs exhibited biomimetic composition, adequate swelling properties in physiological-like environment and superparamagnetic properties. The assembling of Alg induced the egg-like rearrangement of the mineralized composite that was then stabilized through cross-linking reaction with calcium ions.
  
  
  
  The new MHNs can be considered as a promising biocompatible and bio-resorbable drug delivery system with magnetic properties, thus opening to smart applications in nanomedicine.
authors.affiliation: Institute of Science & Technology for Ceramics, National Research Council of Italy, ISTEC-CNR, Faenza, Italy.
authors.forename: Elisabetta
authors.initials: E
authors.lastname: Campodoni
authors.affiliation: Institute of Science & Technology for Ceramics, National Research Council of Italy, ISTEC-CNR, Faenza, Italy.
authors.forename: Alessio
authors.initials: A
authors.lastname: Adamiano
authors.affiliation: Institute of Science & Technology for Ceramics, National Research Council of Italy, ISTEC-CNR, Faenza, Italy.|University "Gabriele D'Annunzio" of Chieti-Pescara, Chieti, Italy.
authors.forename: Samuele M
authors.initials: SM
authors.lastname: Dozio
authors.affiliation: Institute of Science & Technology for Ceramics, National Research Council of Italy, ISTEC-CNR, Faenza, Italy.
authors.forename: Silvia
authors.initials: S
authors.lastname: Panseri
authors.affiliation: Institute of Science & Technology for Ceramics, National Research Council of Italy, ISTEC-CNR, Faenza, Italy.
authors.forename: Monica
authors.initials: M
authors.lastname: Montesi
authors.affiliation: Institute of Science & Technology for Ceramics, National Research Council of Italy, ISTEC-CNR, Faenza, Italy.
authors.forename: Simone
authors.initials: S
authors.lastname: Sprio
authors.affiliation: Institute of Science & Technology for Ceramics, National Research Council of Italy, ISTEC-CNR, Faenza, Italy.
authors.forename: Anna
authors.initials: A
authors.lastname: Tampieri
authors.affiliation: Institute of Science & Technology for Ceramics, National Research Council of Italy, ISTEC-CNR, Faenza, Italy.
authors.forename: Monica
authors.initials: M
authors.lastname: Sandri
mesh_terms: D000464:Alginates / Q000737:chemistry*; D002118:Calcium / Q000737:chemistry; D004337:Drug Carriers / Q000737:chemistry*; D016503:Drug Delivery Systems; D017886:Durapatite / Q000737:chemistry*; D020723:Glucuronic Acid / Q000737:chemistry; D006603:Hexuronic Acids / Q000737:chemistry; D007501:Iron / Q000737:chemistry*; D059346:Magnets / Q000737:chemistry*; D053758:Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure
chemical_list: D000464:Alginates; D004337:Drug Carriers; D006603:Hexuronic Acids; D020723:Glucuronic Acid; D017886:Durapatite; D007501:Iron; D002118:Calcium
keywords: drug delivery; hybrid nanoparticles; iron-doped apatite; nanotechnology; regenerative medicine; superparamagnetism