title: Does masked hypertension impact left ventricular deformation?
abstract: Our aim was to compare left ventricular (LV) deformation in subjects with masked hypertension (MH) to normotensive and sustained hypertensive patients. This cross-sectional study included 185 untreated subjects who underwent 24-hour ambulatory blood pressure (BP) monitoring and complete two-dimensional echocardiographic (2DE) examination including multilayer strain analysis. MH was diagnosed if clinic BP was normal (<140/90 mm Hg), and 24-hour BP was increased (≥130/80 mm Hg). 2DE LV longitudinal and circumferential strains gradually and significantly decreased from normotensive controls across MH individuals to sustained hypertensive patients. 2DE radial strain was not different between groups. 2DE longitudinal and circumferential endocardial and midmyocardial layer strains progressively decreased from normotensive control to sustained hypertensive individuals. Longitudinal and circumferential epicardial layer strains were lower in sustained hypertensive patients than in normotensive controls. Clinic and 24-hour systolic BP were associated with 2DE LV longitudinal endocardial strain, midmyocardial strain, and 2DE circumferential endocardial strain in the whole-study population independent of LV structure and diastolic function. MH significantly affect LV deformation assessed by 2DE traditional strain and 2DE multilayer strain. Clinic and 24-hour systolic BP were associated with LV mechanics evaluated with comprehensive 2DE strain analysis independent of LV structure and diastolic function.
authors.affiliation: Cardiology Department, University Clinical Hospital Center "Dr. Dragisa Misovic-Dedinje", Belgrade, Serbia; School of Medicine, Belgrade University, Belgrade, Serbia. Electronic address: marijana_tadic@hotmail.com.
authors.forename: Marijana
authors.initials: M
authors.lastname: Tadic
authors.affiliation: Clinical Research Unit, University of Milan-Bicocca and Istituto Auxologico Italiano, Meda, Italy.
authors.forename: Cesare
authors.initials: C
authors.lastname: Cuspidi
authors.affiliation: Cardiology Department, University Clinical Hospital Center "Dr. Dragisa Misovic-Dedinje", Belgrade, Serbia.
authors.forename: Vladan
authors.initials: V
authors.lastname: Vukomanovic
authors.affiliation: Cardiology Department, University Clinical Hospital Center "Dr. Dragisa Misovic-Dedinje", Belgrade, Serbia; School of Medicine, Belgrade University, Belgrade, Serbia.
authors.forename: Vera
authors.initials: V
authors.lastname: Celic
authors.affiliation: School of Medicine, University of Nis, Nis, Serbia.
authors.forename: Ivan
authors.initials: I
authors.lastname: Tasic
authors.affiliation: Cardiology Department, University Clinical Hospital Center "Dr. Dragisa Misovic-Dedinje", Belgrade, Serbia.
authors.forename: Ana
authors.initials: A
authors.lastname: Stevanovic
authors.affiliation: Cardiology Department, University Clinical Hospital Center "Dr. Dragisa Misovic-Dedinje", Belgrade, Serbia.
authors.forename: Vesna
authors.initials: V
authors.lastname: Kocijancic
mesh_terms: D000368:Aged; D018660:Blood Pressure Monitoring, Ambulatory; D003430:Cross-Sectional Studies; D004452:Echocardiography; D005260:Female; D006352:Heart Ventricles / Q000000981:diagnostic imaging / Q000473:pathology*; D006801:Humans; D008297:Male; D059468:Masked Hypertension / Q000150:complications*; D008875:Middle Aged; D010496:Pericardium / Q000000981:diagnostic imaging / Q000473:pathology*
keywords: Arterial hypertension; function; left ventricular structure; mechanics