title: [Clinical value of T-cell interferon releases detection of tuberculosis infection assay in quick diagnosis of spinal tuberculosis].
abstract: OBJECTIVE
  To evaluate the value of T-cell interferon releases detection of tuberculosis infection(T-SPOT.TB)assay in quick diagnosis of spinal tuberculosis.
  
  
  METHODS
  From January 2012 to June 2015, a group of 122 diagnosed patients with spinal tuberculosis in the Qingdao Municipal Chest Hospital and a group of 86 patients suspected with spinal tuberculosis in Department of Orthopaedic, the Qingdao Third People's Hospital were accepted to undergone TB-DOT, T-SPOT.TB and TB-DNA PCR tests Department of Clinical Laboratory.
  
  
  RESULTS
  The sensitivity of TB-DOT, T-SPOT.TB and TB-DNA PCR tests were 69.7%, 86.1% and 56.6%, respectively.The sensitivity of T-SPOT.TB was significantly higher than TB-DOT and TB-DNA PCR tests (χ(2)=9.51, P<0.05; χ(2)=25.96, P<0.05). The specificity of TB-DOT, T-SPOT.TB and TB-DNA PCR tests were 62.8%, 88.3% and 91.9%, respectively.The specificity of T-SPOT.TB was significantly higher than TB-DOT test (χ(2)=15.25, P<0.05).
  
  
  CONCLUSIONS
  T-SPOT.TB assay possesses high sensitivity and specificity in quick diagnosis of patients with spinal tuberculosis, which is valuable in diagnosis of spinal tuberculosis.
authors.affiliation: Department of Clinical Laboratory, Qingdao Municipal Chest Hospital, Qingdao 266041, China.
authors.forename: Y Z
authors.initials: YZ
authors.lastname: Hua
authors.forename: S Y
authors.initials: SY
authors.lastname: Cheng
authors.forename: G H
authors.initials: GH
authors.lastname: Jiang
authors.forename: M W
authors.initials: MW
authors.lastname: Zhao
mesh_terms: D006761:Hospitals; D006801:Humans; D006967:Hypersensitivity; D007372:Interferons; D010351:Patient Discharge; D016133:Polymerase Chain Reaction; D013601:T-Lymphocytes; D013909:Thorax; D014399:Tuberculosis, Spinal
chemical_list: D007372:Interferons