title: Association study of C-reactive protein associated gene HNF1A with ischemic stroke in Chinese population.
abstract: Ischemic stroke is a life-threatening condition due to obstructed blood supply of the brain. Elevation of plasma C-reactive protein, an important inflammatory marker, was known to associate with increased risk of ischemic stroke. Previous studies reported association between genetic variants of HNF1A and plasma level of C-reactive protein. The HNF1A gene encodes a hepatocyte transcription factor which might have regulatory effects on C-reactive protein synthesis in liver. Therefore, the C-reactive protein associated gene HNF1A seems to be a promising candidate gene for ischemic stroke.
  
  
  
  We used HNF1A as a candidate gene of ischemic stroke and evaluated seven common variants of HNF1A for their contribution to ischemic stroke. The association analysis of HNF1A variants with ischemic stroke was performed in a Chinese population with 918 cases and 979 controls. For total ischemic stroke and large vessel disease subtype, none of variants exceeded significant threshold. For small vessel disease subtype of ischemic stroke, the G allele of rs7953249 showed nominal association (OR = 0.82, p = 0.04) after data adjustment for conventional risk factors. However, our preliminary results did not survived bonferroni correction for multiple comparisons.
  
  
  
  Common genetic variants of HNF1A showed nominal association with small vessel disease subtype of ischemic stroke though not survived bonferroni correction for multiple comparisons. The association between HNF1A and ischemic stroke is limited by small effects of individual SNPs. Our study provided additional genetic evidences to understand the role of HNF1A gene and C-reactive protein underlying ischemic stroke.
authors.affiliation: Fujian University of Traditional Chinese Medicine, No.1 Qiuyang Road, Shangjie, Minhou, Fuzhou, 350122, China.|Fujian University of Traditional Chinese Medicine Subsidiary Rehabilitation Hospital, Fuzhou, China.|Academy of Integrative Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou, China.
authors.forename: Haibin
authors.initials: H
authors.lastname: Shi
authors.affiliation: Health Management Center, The Second Hospital of Dalian Medical University, Dalian, China.
authors.forename: Song
authors.initials: S
authors.lastname: Leng
authors.affiliation: Department of Neurology, The People's Hospital of Fujian Province, Fuzhou, China.
authors.forename: Hui
authors.initials: H
authors.lastname: Liang
authors.affiliation: The Second People's Hospital Affiliated to Fujian University of Traditional Chinese Medicine, Fuzhou, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Zheng
authors.affiliation: Fujian University of Traditional Chinese Medicine, No.1 Qiuyang Road, Shangjie, Minhou, Fuzhou, 350122, China. cld@fjtcm.edu.cn.
authors.forename: Lidian
authors.initials: L
authors.lastname: Chen
mesh_terms: D000368:Aged; D000483:Alleles; D044466:Asian People / Q000235:genetics*; D002097:C-Reactive Protein / Q000032:analysis*; D016022:Case-Control Studies; D002681:China; D005260:Female; D055106:Genome-Wide Association Study; D005838:Genotype; D051538:Hepatocyte Nuclear Factor 1-alpha / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D020521:Stroke / Q000235:genetics* / Q000473:pathology
chemical_list: C496487:HNF1A protein, human; D051538:Hepatocyte Nuclear Factor 1-alpha; D002097:C-Reactive Protein
keywords: Association study; C-reactive protein; HNF1A; Ischemic stroke; Single nucleotide polymorphism