title: Osteonecrosis of the Jaw-a Bone Site-Specific Effect of Bisphosphonates.
abstract: A known complication that can occur in patients using bisphosphonates (BPs) is osteonecrosis of the jaw (ONJ). ONJ features bone exposure that may be associated with severe pain, swelling, local infection, and pathological fracture of the jaw. Current literature indicates that a complex combination of factors is necessary to induce ONJ. Several hypotheses about the pathophysiology of ONJ were previously reported. Here, we review these hypotheses and introduce new ideas and suggestions on this topic, focusing on bone site-specific cells, and the effect that BPs and other anti-resorptive drugs have on those cells. Gaining more insight into bone site-specific effects may help to better understand the pathogenesis ONJ, and contribute to the development of new bone site-specific anti-resorptive drugs.
authors.affiliation: Department of Oral Cell Biology and Functional Anatomy, Academic Centre for Dentistry Amsterdam (ACTA), University of Amsterdam and VU University Amsterdam, MOVE Research Institute Amsterdam, Gustav Mahlerlaan 3004, 1081 LA, Amsterdam, The Netherlands.
authors.forename: Jenny A F
authors.initials: JA
authors.lastname: Vermeer
authors.affiliation: Department of Oral Cell Biology and Functional Anatomy, Academic Centre for Dentistry Amsterdam (ACTA), University of Amsterdam and VU University Amsterdam, MOVE Research Institute Amsterdam, Gustav Mahlerlaan 3004, 1081 LA, Amsterdam, The Netherlands.
authors.forename: Greetje A P
authors.initials: GA
authors.lastname: Renders
authors.affiliation: Department of Oral Cell Biology and Functional Anatomy, Academic Centre for Dentistry Amsterdam (ACTA), University of Amsterdam and VU University Amsterdam, MOVE Research Institute Amsterdam, Gustav Mahlerlaan 3004, 1081 LA, Amsterdam, The Netherlands. v.everts@acta.nl.
authors.forename: Vincent
authors.initials: V
authors.lastname: Everts
mesh_terms: D000818:Animals; D059266:Bisphosphonate-Associated Osteonecrosis of the Jaw / Q000378:metabolism* / Q000503:physiopathology; D001853:Bone Marrow; D016723:Bone Remodeling; D001842:Bone and Bones / Q000378:metabolism*; D060833:Cellular Microenvironment; D004195:Disease Models, Animal; D006801:Humans; D010006:Osteoblasts; D010010:Osteoclasts
keywords: Bisphosphonates; Bone marrow; Jaw; Microenvironment; ONJ; Osteoclast; Osteonecrosis