title: Unlocking tumor vascular barriers with CXCR3: Implications for cancer immunotherapy.
abstract: Promising cancer immunotherapeutics depend on mobilization of cytotoxic T cells across tumor vascular barriers through mechanisms that are poorly understood. Recently, we discovered that the CXCR3 chemokine receptor uniquely functions as the master-regulator of cytotoxic CD8(+) T cell extravasation and tumor control despite the multiplicity of chemokines available in the tumor landscape.
authors.affiliation: Department of Immunology, Roswell Park Cancer Institute , Buffalo, NY, USA.
authors.forename: Maryann E
authors.initials: ME
authors.lastname: Mikucki
authors.affiliation: Department of Immunology, Roswell Park Cancer Institute, Buffalo, NY, USA; Department of Surgical Oncology, Roswell Park Cancer Institute, Buffalo, NY, USA.
authors.forename: Joseph J
authors.initials: JJ
authors.lastname: Skitzki
authors.affiliation: Department of Microbiology and Immunology, University of Rochester Medical Center and the Wilmot Cancer Center , Rochester, NY, USA.
authors.forename: John G
authors.initials: JG
authors.lastname: Frelinger
authors.affiliation: Center for Immunotherapy, Roswell Park Cancer Institute, Buffalo, NY, USA; Department of Gynecologic Oncology, Roswell Park Cancer Institute, Buffalo, NY, USA.
authors.forename: Kunle
authors.initials: K
authors.lastname: Odunsi
authors.affiliation: Department of Medicine, University of Chicago, Chicago, IL, USA; Department of Pathology, University of Chicago, Chicago, IL, USA; Comprehensive Cancer Center and Committee on Immunology, University of Chicago, Chicago, IL, USA.
authors.forename: Thomas F
authors.initials: TF
authors.lastname: Gajewski
authors.affiliation: Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Harvard Medical School , Boston, MA, USA.
authors.forename: Andrew D
authors.initials: AD
authors.lastname: Luster
authors.affiliation: Department of Immunology, Roswell Park Cancer Institute , Buffalo, NY, USA.
authors.forename: Sharon S
authors.initials: SS
authors.lastname: Evans
keywords: Adoptive T cell transfer; CXCR3; T cell trafficking; cancer immunotherapy; chemokine receptor; tumor vessels