title: Circadian clock control of hepatic lipid metabolism: role of small heterodimer partner (Shp).
abstract: Hepatic steatosis, the accumulation of triglyceride droplets in the hepatocytes, is a common hepatic pathology seen in subjects with obesity/metabolic syndrome and those with excessive alcohol use. The pathogenesis underlying hepatic steatosis is complex. Recent studies have shown the specific role played by the molecular clock mechanism in the control of lipid metabolism and that the disruption of these tissue clocks may lead to the disturbances in lipid homeostasis. This review reports a novel role of small heterodimer partner in maintaining triglyceride and lipoprotein homeostasis through neuronal PAS domain protein 2.
authors.affiliation: Department of Physiology & Neurobiology, University of Connecticut, Storrs, Connecticut, USA Veterans Affairs Connecticut Healthcare System, West Haven, Connecticut, USA Department of Internal Medicine, Section of Digestive Diseases, Yale University, New Haven, Connecticut, USA School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, China.
authors.forename: Li
authors.initials: L
authors.lastname: Wang
authors.affiliation: Division of Gastroenterology and Hepatology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA Roudebush Veterans Administration Medical Center, Indianapolis, Indiana, USA Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, Indiana, USA.
authors.forename: Suthat
authors.initials: S
authors.lastname: Liangpunsakul
mesh_terms: D000818:Animals; D057906:Circadian Clocks; D006801:Humans; D050356:Lipid Metabolism; D008099:Liver / Q000378:metabolism*; D008954:Models, Biological; D018160:Receptors, Cytoplasmic and Nuclear / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D018160:Receptors, Cytoplasmic and Nuclear; C099713:nuclear receptor subfamily 0, group B, member 2
keywords: Lipid Metabolism