title: Protein aggregation and neurodegenerative diseases: From theory to therapy.
abstract: The study of protein misfolding and aggregation saw resurgence in the last decade. Aggregation is the main cause of several human neurodegenerative diseases which makes this field as the leading edge in the science today. Protein aggregation is a highly complex process resulting in formation of a variety of aggregates with different structures and morphologies. Many of them are highly cytotoxic. In-depth knowledge about structure, mechanism of formation, and physiological effects of aggregates will shed new light on the aggregation-mediated cell toxicity, and helps in deciphering new target for drug design and development. This review summarizes the existing information on the molecular mechanism of protein misfolding and aggregation involved in neurodegeneration stressing on the possible therapeutic intervention in neurodegenerative diseases. As our knowledge about the relation between the protein misfolding and disease pathogenesis will be enhanced, more specific and promising treatment opportunities will come into existence.
authors.affiliation: Centre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, Jamia Nagar, New Delhi, 10025, India. Electronic address: vijay9595@st.jmi.ac.in.
authors.forename: Vijay
authors.initials: V
authors.lastname: Kumar
authors.affiliation: Centre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, Jamia Nagar, New Delhi, 10025, India.
authors.forename: Neha
authors.initials: N
authors.lastname: Sami
authors.affiliation: Centre for Biological Sciences, Central University of South Bihar, Patna, 800014, India.
authors.forename: Tara
authors.initials: T
authors.lastname: Kashav
authors.affiliation: Centre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, Jamia Nagar, New Delhi, 10025, India.
authors.forename: Asimul
authors.initials: A
authors.lastname: Islam
authors.affiliation: Centre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, Jamia Nagar, New Delhi, 10025, India.
authors.forename: Faizan
authors.initials: F
authors.lastname: Ahmad
authors.affiliation: Centre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, Jamia Nagar, New Delhi, 10025, India. Electronic address: mihassan@jmi.ac.in.
authors.forename: Md Imtaiyaz
authors.initials: MI
authors.lastname: Hassan
mesh_terms: D000818:Animals; D016923:Cell Death; D002986:Clinical Trials as Topic; D006801:Humans; D019636:Neurodegenerative Diseases / Q000150:complications / Q000378:metabolism* / Q000473:pathology / Q000628:therapy*; D009474:Neurons / Q000473:pathology; D066329:Protein Aggregates; D057165:Proteostasis Deficiencies / Q000150:complications
chemical_list: D066329:Protein Aggregates
keywords: Cell toxicity; Drug target; Misfolding and aggregation; Neurodegenerative diseases; Therapeutic intervention