title: Is Immunomodulation a Principal Mechanism Underlying How Cell-Based Therapies Enhance Stroke Recovery?
abstract: Inflammation within the brain and in peripheral tissues contributes to brain injury following ischemic stroke. Therapeutic modulation of the inflammatory response has been actively pursued as a novel stroke treatment approach for decades, without success. In recent years, extensive studies support the high potential for cell-based therapies to become a new treatment modality for stroke and other neurological disorders. In this review, we explore different types of cellular therapies and discuss how they modulate central and peripheral inflammatory processes after stroke. Apart from identifying potential targets for cell therapy, we also discuss paracrine and immunomodulatory mechanisms of cell therapy.
authors.affiliation: Stroke Program, McGovern Medical School, UTHealth, Houston, TX, USA. nikunj.b.satani@uth.tmc.edu.
authors.forename: Nikunj
authors.identifier: 0000-0003-3908-3731
authors.initials: N
authors.lastname: Satani
authors.affiliation: Stroke Program, McGovern Medical School, UTHealth, Houston, TX, USA.
authors.forename: Sean I
authors.initials: SI
authors.lastname: Savitz
mesh_terms: D000818:Animals; D064987:Cell- and Tissue-Based Therapy / Q000379:methods*; D006801:Humans; D056747:Immunomodulation / Q000502:physiology*; D020127:Recovery of Function / Q000502:physiology*; D020521:Stroke / Q000628:therapy*
keywords: Cell-based therapy; Immune response; Inflammation; Microglia; Spleen; Stroke