title: The association of three promoter polymorphisms in interleukin-10 gene with the risk for colorectal cancer and hepatocellular carcinoma: A meta-analysis.
abstract: Mounting evidence supports a potent inhibitory role of interleukin-10 (IL-10) in tumor carcinogenesis, angiogenesis and metastasis. This meta-analysis was designed to examine the association of three promoter polymorphisms (-592C > A, -819C > T and -1082G > A) in IL-10 gene with the risk for colorectal cancer and hepatocellular carcinoma. Qualification assessment and data collection were completed by two authors independently. The random-effects model using the DerSimonian and Laird method was fitted by the STATA software. Twenty-five articles involving 5933 cases and 9724 controls were meta-analyzed. Overall comparisons of the mutant alleles (-592A, -819T and -1082A) of three promoter polymorphisms with alternative wild alleles failed to reveal any statistical significance for both colorectal cancer and hepatocellular carcinoma (P > 0.05), and the likelihood of heterogeneity was low (I(2) < 50%). For -592C > A polymorphism, a significant risk for colorectal cancer was identified when analysis was restricted to East Asians (odds ratio or OR = 1.41, 95% confidence interval or CI: 1.18-1.68, P < 0.001) and retrospective studies (OR = 1.23, 95% CI: 1.09-1.39, P = 0.001). As weighed by the Egger's test and the fill-and-trim method, there was a low probability of publication bias for all studied polymorphisms. Our findings collectively suggest that the -592C > A polymorphism in IL-10 gene might be a susceptibility locus for colorectal cancer in East Asians.
authors.affiliation: Department of Gastroenterology, The First Hospital of Qiqihar City, Qiqihar, Heilongjiang, China.
authors.forename: Yan-Hui
authors.initials: YH
authors.lastname: Shi
authors.affiliation: Department of Gastroenterology, The First Hospital of Qiqihar City, Qiqihar, Heilongjiang, China.
authors.forename: Dong-Mei
authors.initials: DM
authors.lastname: Zhao
authors.affiliation: Department of Physiology, Qiqihar Medical University, Qiqihar, Heilongjiang, China.
authors.forename: Yue-Fei
authors.initials: YF
authors.lastname: Wang
authors.affiliation: Department of Physiology, Qiqihar Medical University, Qiqihar, Heilongjiang, China.
authors.forename: Xue
authors.initials: X
authors.lastname: Li
authors.affiliation: Department of Gastroenterology, The First Hospital of Qiqihar City, Qiqihar, Heilongjiang, China.
authors.forename: Man-Ru
authors.initials: MR
authors.lastname: Ji
authors.affiliation: Department of Gastroenterology, The First Hospital of Qiqihar City, Qiqihar, Heilongjiang, China.
authors.forename: Dan-Na
authors.initials: DN
authors.lastname: Jiang
authors.affiliation: Intervention Therapy Department, The First Hospital of Qiqihar City, Qiqihar, Heilongjiang, China.
authors.forename: Bai-Ping
authors.initials: BP
authors.lastname: Xu
authors.affiliation: Central Laboratory, Qiqihar Medical University, Qiqihar, Heilongjiang, China.
authors.forename: Li
authors.initials: L
authors.lastname: Zhou
authors.affiliation: Department of Physiology, Qiqihar Medical University, Qiqihar, Heilongjiang, China.
authors.forename: Chang-Zhu
authors.initials: CZ
authors.lastname: Lu
authors.affiliation: Department of Physiology, Qiqihar Medical University, Qiqihar, Heilongjiang, China.
authors.forename: Bin
authors.initials: B
authors.lastname: Wang
mesh_terms: D044466:Asian People / Q000235:genetics; D006528:Carcinoma, Hepatocellular / Q000235:genetics*; D015179:Colorectal Neoplasms / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D006801:Humans; D016753:Interleukin-10 / Q000235:genetics*; D008113:Liver Neoplasms / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D011401:Promoter Regions, Genetic / Q000235:genetics
chemical_list: C508609:IL10 protein, human; D016753:Interleukin-10