title: Clinical significance of ventilator-associated event.
abstract: A novel surveillance algorithm of ventilator-associated event (VAE) was introduced to overcome the subjectivity of conventional ventilator-associated pneumonia. We investigated the risk factors and prognostic values of VAE.
  
  
  
  We conducted a retrospective study of 869 patients treated with mechanical ventilation for greater than or equal to 2 calendar days from January 2013 to June 2014. We compared the episodes of mechanical ventilation with or without VAE and analyzed risk factors and clinical outcomes of VAE.
  
  
  
  Among 1031 episodes of mechanical ventilation, 92 episodes were complicated with VAE. VAE occurred more frequently when the initial causes of mechanical ventilation were trauma (odds ratio [OR], 2.7; 95% confidence interval [CI], 1.1-6.3) and pulmonary edema (OR, 2.4; 95% CI, 1.2-4.7). VAE was significantly associated with prolonged mechanical ventilation (5 vs 12 days; P<.001), reduced rate of successful extubation (50.1% vs 17.5%; P<.001), and increased 30-day mortality (35.6% vs 74.2%; P<.001). VAE was a significant risk factor of 30-day mortality on multivariate regression analysis (OR, 3.6; 95% CI, 2.0-6.6; P<.001).
  
  
  
  Patients treated with mechanical ventilation due to pulmonary edema or trauma had increased risk of VAE, with its development indicative of adverse clinical outcomes.
authors.affiliation: Division of Pulmonary, Allergy and Critical Care Medicine, Department of Internal Medicine, Korea University Guro Hospital, Korea University College of Medicine, Seoul, Republic of Korea.
authors.forename: Jae Kyeom
authors.initials: JK
authors.lastname: Sim
authors.affiliation: Division of Pulmonary, Allergy and Critical Care Medicine, Department of Internal Medicine, Korea University Guro Hospital, Korea University College of Medicine, Seoul, Republic of Korea. Electronic address: happymaria0101@hanmail.net.
authors.forename: Jee Youn
authors.initials: JY
authors.lastname: Oh
authors.affiliation: Division of Pulmonary, Allergy and Critical Care Medicine, Department of Internal Medicine, Korea University Guro Hospital, Korea University College of Medicine, Seoul, Republic of Korea.
authors.forename: Kyung Hoon
authors.initials: KH
authors.lastname: Min
authors.affiliation: Division of Pulmonary, Allergy and Critical Care Medicine, Department of Internal Medicine, Korea University Guro Hospital, Korea University College of Medicine, Seoul, Republic of Korea.
authors.forename: Gyu Young
authors.initials: GY
authors.lastname: Hur
authors.affiliation: Division of Pulmonary, Sleep and Critical Care Medicine, Department of Internal Medicine, Korea University Ansan Hospital, Korea University College of Medicine, Ansan, Republic of Korea.
authors.forename: Seung Heon
authors.initials: SH
authors.lastname: Lee
authors.affiliation: Division of Pulmonary, Allergy and Critical Care Medicine, Department of Internal Medicine, Korea University Guro Hospital, Korea University College of Medicine, Seoul, Republic of Korea.
authors.forename: Sung Yong
authors.initials: SY
authors.lastname: Lee
authors.affiliation: Division of Pulmonary, Sleep and Critical Care Medicine, Department of Internal Medicine, Korea University Ansan Hospital, Korea University College of Medicine, Ansan, Republic of Korea.
authors.forename: Je Hyeong
authors.initials: JH
authors.lastname: Kim
authors.affiliation: Division of Pulmonary, Sleep and Critical Care Medicine, Department of Internal Medicine, Korea University Ansan Hospital, Korea University College of Medicine, Ansan, Republic of Korea.
authors.forename: Chol
authors.initials: C
authors.lastname: Shin
authors.affiliation: Division of Pulmonary, Allergy and Critical Care Medicine, Department of Internal Medicine, Korea University Guro Hospital, Korea University College of Medicine, Seoul, Republic of Korea.
authors.forename: Jae Jeong
authors.initials: JJ
authors.lastname: Shim
authors.affiliation: Division of Pulmonary, Allergy and Critical Care Medicine, Department of Internal Medicine, Korea University Guro Hospital, Korea University College of Medicine, Seoul, Republic of Korea.
authors.forename: Kyung Ho
authors.initials: KH
authors.lastname: Kang
mesh_terms: D000368:Aged; D060666:Airway Extubation / Q000009:adverse effects; D003422:Critical Care; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D053717:Pneumonia, Ventilator-Associated / Q000453:epidemiology* / Q000517:prevention & control; D056910:Republic of Korea / Q000453:epidemiology; D012121:Respiration, Artificial / Q000009:adverse effects; D012189:Retrospective Studies; D012307:Risk Factors
keywords: Pulmonary edema; Trauma; Ventilator-associated event; Ventilator-associated pneumonia