title: Wrinkling Non-Spherical Particles and Its Application in Cell Attachment Promotion.
abstract: Surface wrinkled particles are ubiquitous in nature and present in different sizes and shapes, such as plant pollens and peppercorn seeds. These natural wrinkles provide the particles with advanced functions to survive and thrive in nature. In this work, by combining flow lithography and plasma treatment, we have developed a simple method that can rapidly create wrinkled non-spherical particles, mimicking the surface textures in nature. Due to the oxygen inhibition in flow lithography, the non-spherical particles synthesized in a microfluidic channel are covered by a partially cured polymer (PCP) layer. When exposed to plasma treatment, this PCP layer rapidly buckles, forming surface-wrinkled particles. We designed and fabricated various particles with desired shapes and sizes. The surfaces of these shapes were tuned to created wrinkle morphologies by controlling UV exposure time and the washing process. We further demonstrated that wrinkles on the particles significantly promoted cell attachment without any chemical modification, potentially providing a new route for cell attachment for various biomedical applications.
authors.affiliation: Department of Chemical Engineering, Ryerson University, 350 Victoria Street, Toronto, Ontario, M5B 2K3, Canada.|Li Ka Shing Knowledge Institute, St. Michael's Hospital, 30 Bond Street, Toronto, Ontario, M5B 1W8, Canada.
authors.forename: Minggan
authors.initials: M
authors.lastname: Li
authors.affiliation: Department of Chemical Engineering, Ryerson University, 350 Victoria Street, Toronto, Ontario, M5B 2K3, Canada.
authors.forename: Dehi
authors.initials: D
authors.lastname: Joung
authors.affiliation: Department of Chemical Engineering, Ryerson University, 350 Victoria Street, Toronto, Ontario, M5B 2K3, Canada.
authors.forename: Bethany
authors.initials: B
authors.lastname: Hughes
authors.affiliation: Department of Chemical Engineering, Ryerson University, 350 Victoria Street, Toronto, Ontario, M5B 2K3, Canada.|Li Ka Shing Knowledge Institute, St. Michael's Hospital, 30 Bond Street, Toronto, Ontario, M5B 1W8, Canada.
authors.forename: Stephen D
authors.initials: SD
authors.lastname: Waldman
authors.affiliation: Lassonde School of Engineering, York University, Keele Street, Toronto, Ontario, M3J 1P3, Canada.
authors.forename: Janusz A
authors.initials: JA
authors.lastname: Kozinski
authors.affiliation: Department of Chemical Engineering, Ryerson University, 350 Victoria Street, Toronto, Ontario, M5B 2K3, Canada.|Li Ka Shing Knowledge Institute, St. Michael's Hospital, 30 Bond Street, Toronto, Ontario, M5B 1W8, Canada.
authors.forename: Dae Kun
authors.initials: DK
authors.lastname: Hwang
mesh_terms: D000818:Animals; D002417:Cattle; D002448:Cell Adhesion; D005347:Fibroblasts / Q000166:cytology* / Q000648:ultrastructure; D044085:Microfluidics; D018613:Microscopy, Confocal; D056951:Photoelectron Spectroscopy; D011108:Polymers / Q000737:chemistry*; D013499:Surface Properties; D013997:Time Factors; D014466:Ultraviolet Rays
chemical_list: D011108:Polymers