title: Integrins AV and B8 Gene Polymorphisms and Risk for Intracerebral Hemorrhage in Greek and Polish Populations.
abstract: Α limited number of genetic variants have been linked to the development of intracerebral hemorrhage (ICH). Ιntegrin AV and/or B8-deficient mice were found to develop ICH. The present candidate gene association study was designed to investigate possible influence of integrin AV (ITGAV) and integrin B8 (ITGB8) gene region polymorphisms on the risk of ICH. 1015 participants (250 Greek and 193 Polish patients with primary ICH and 250 Greek and 322 Polish controls) were included in the study. Using logistic regression analyses, 11 tag single nucleotide polymorphisms (SNPs) for ITGAV and 11 for ITGB8 gene were tested for associations with ICH risk, lobar ICH risk and non-lobar ICH after adjustment for age, gender, history of hypertension and country of origin. Linear regression models were used to test the effect of tag SNPs on the ICH age of onset. Correction for multiple comparisons was carried out. The rs7565633 tag SNP of the ITGAV gene was independently associated with the risk of lobar ICH in the codominant model of inheritance [odds ratio (95 % confidence interval (CI)) 0.56 (0.36-0.86), p = 0.0013]. Furthermore, heterozygous individuals of the rs10251386 and the rs10239099 of the ITGB8 gene had significantly lower age of ICH onset compared to the wild-type genotypes [regression coefficient (b) -3.884 (95 % CI -6.519, -1.249), p = 0.0039 and b = -4.502 (95 % CI -7.159, -1.845), p = 0.0009, respectively]. The present study provides preliminary indication for an influence of ITGAV gene tag SNP in the development of lobar ICH and of ITGB8 gene variants in the age of ICH onset.
authors.affiliation: Laboratory of Neurogenetics, Department of Neurology, Faculty of Medicine, University of Thessaly, University Hospital of Larissa, Biopolis, Mezourlo Hill, 41100, Larissa, Greece.
authors.forename: Efthimios
authors.initials: E
authors.lastname: Dardiotis
authors.affiliation: Laboratory of Neurogenetics, Department of Neurology, Faculty of Medicine, University of Thessaly, University Hospital of Larissa, Biopolis, Mezourlo Hill, 41100, Larissa, Greece.
authors.forename: Vasileios
authors.initials: V
authors.lastname: Siokas
authors.affiliation: Intensive Care Unit, General Hospital of Larissa, Larissa, Greece.
authors.forename: Tilemachos
authors.initials: T
authors.lastname: Zafeiridis
authors.affiliation: Department of Neurosurgery, University of Thessaly, University Hospital of Larissa, Larissa, Greece.
authors.forename: Konstantinos
authors.initials: K
authors.lastname: Paterakis
authors.affiliation: Second Department of Neurology, University of Athens, School of Medicine, "Attikon" University Hospital, Athens, Greece.|International Clinical Research Center, St. Anne's University Hospital in Brno, Brno, Czech Republic.
authors.forename: Georgios
authors.initials: G
authors.lastname: Tsivgoulis
authors.affiliation: Laboratory of Neurogenetics, Department of Neurology, Faculty of Medicine, University of Thessaly, University Hospital of Larissa, Biopolis, Mezourlo Hill, 41100, Larissa, Greece.
authors.forename: Maria
authors.initials: M
authors.lastname: Dardioti
authors.affiliation: Second Department of Neurosurgery, Hippokration University Hospital, Aristotle University of Thessaloniki, Thessaloníki, Greece.
authors.forename: Savas
authors.initials: S
authors.lastname: Grigoriadis
authors.affiliation: Department of Physiology, Aristotle University of Thessaloniki, Thessaloníki, Greece.
authors.forename: Constantina
authors.initials: C
authors.lastname: Simeonidou
authors.affiliation: Department of Neurology, Papageorgiou General Hospital, Thessaloníki, Greece.
authors.forename: Georgia
authors.initials: G
authors.lastname: Deretzi
authors.affiliation: Department of Biomathematics, University of Thessaly School of Medicine, Larissa, Greece.
authors.forename: Elias
authors.initials: E
authors.lastname: Zintzaras
authors.affiliation: Department of Neurology, Medical College Jagiellonian University, Kraków, Poland.
authors.forename: Jeremiasz
authors.initials: J
authors.lastname: Jagiella
authors.affiliation: Laboratory of Neurogenetics, Department of Neurology, Faculty of Medicine, University of Thessaly, University Hospital of Larissa, Biopolis, Mezourlo Hill, 41100, Larissa, Greece. gmhadji@med.uth.gr.
authors.forename: Georgios M
authors.initials: GM
authors.lastname: Hadjigeorgiou
mesh_terms: D017668:Age of Onset; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D002540:Cerebral Cortex / Q000098:blood supply; D002543:Cerebral Hemorrhage / Q000208:ethnology / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006115:Greece / Q000453:epidemiology; D006801:Humans; D039564:Integrin alphaV / Q000235:genetics*; D039641:Integrin beta Chains / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D011044:Poland / Q000453:epidemiology; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors
chemical_list: D039564:Integrin alphaV; D039641:Integrin beta Chains; C094865:integrin beta8
keywords: ITGAV; ITGB8; Integrins; Intracerebral hemorrhage; Polymorphism; Tag SNPs