title: Multi-layer ventilation inhomogeneity in cystic fibrosis.
abstract: Differences in regional lung function between the 3rd and 5th intercostal space (ICS) were explored in 10 cystic fibrosis (CF) patients and compared to 10 lung-healthy controls by electrical impedance tomography (EIT). Regional ratios of impedance changes corresponding to the maximal volume of air exhaled within the first second of a forced expiration (ΔIFEV1) and the forced vital capacity (ΔIFVC) were determined. Regional airway obstruction and ventilation inhomogeneity were assessed by the frequency distribution of these ratios (ΔIFEV1/ΔIFVC) and an inhomogeneity index (GITI). The mean of the frequency distribution of ΔIFEV1/ΔIFVCand the GITIin both thorax planes were significantly different between CF patients and controls (p<0.001). CF patients exhibited a significantly lower mean of ΔIFEV1/ΔIFVCfrequency distribution (p<0.05) and a significantly higher degree of ventilation inhomogeneity (p<0.01) in the 3rd ICS compared to the 5th ICS. Results indicated that EIT measurements at more cranial thorax planes may benefit the early diagnosis in CF.
authors.affiliation: Institute of Technical Medicine, Furtwangen University, Jakob-Kienzle-Straße 17, 78054 Villingen-Schwenningen, Germany; Department of Radiology, LMU University of Munich, Ziemssenstrasse 1, 80336 Munich, Germany(1). Electronic address: Sabine.Krueger-Ziolek@hs-furtwangen.de.
authors.forename: Sabine
authors.initials: S
authors.lastname: Krueger-Ziolek
authors.affiliation: Institute of Technical Medicine, Furtwangen University, Jakob-Kienzle-Straße 17, 78054 Villingen-Schwenningen, Germany; Department of Radiology, LMU University of Munich, Ziemssenstrasse 1, 80336 Munich, Germany(1).
authors.forename: Benjamin
authors.initials: B
authors.lastname: Schullcke
authors.affiliation: Institute of Technical Medicine, Furtwangen University, Jakob-Kienzle-Straße 17, 78054 Villingen-Schwenningen, Germany.
authors.forename: Zhanqi
authors.initials: Z
authors.lastname: Zhao
authors.affiliation: Institute of Technical Medicine, Furtwangen University, Jakob-Kienzle-Straße 17, 78054 Villingen-Schwenningen, Germany; Department of Radiology, LMU University of Munich, Ziemssenstrasse 1, 80336 Munich, Germany(1).
authors.forename: Bo
authors.initials: B
authors.lastname: Gong
authors.affiliation: Medizinische Klinik V (Pneumology), LMU University of Munich, Ziemssenstrasse 1, 80336 Munich, Germany(1).
authors.forename: Susanne
authors.initials: S
authors.lastname: Naehrig
authors.affiliation: Department of Radiology, LMU University of Munich, Ziemssenstrasse 1, 80336 Munich, Germany(1).
authors.forename: Ullrich
authors.initials: U
authors.lastname: Müller-Lisse
authors.affiliation: Institute of Technical Medicine, Furtwangen University, Jakob-Kienzle-Straße 17, 78054 Villingen-Schwenningen, Germany.
authors.forename: Knut
authors.initials: K
authors.lastname: Moeller
mesh_terms: D000328:Adult; D003550:Cystic Fibrosis / Q000473:pathology* / Q000503:physiopathology*; D017097:Electric Impedance; D005260:Female; D005541:Forced Expiratory Volume / Q000502:physiology; D006801:Humans; D008168:Lung / Q000503:physiopathology*; D008176:Lung Volume Measurements; D008297:Male; D008875:Middle Aged; D012123:Pulmonary Ventilation / Q000502:physiology*; D013147:Spirometry; D014054:Tomography; D014797:Vital Capacity / Q000502:physiology
keywords: Cystic fibrosis; Electrical impedance tomography; Regional lung function; Ventilation inhomogeneity