title: Analysis of extended haplotype in Korean cattle (Hanwoo) population.
abstract: Korean cattle (Hanwoo) are categorized into three breeds based on color: brown, brindle, and black. Among these breeds, brown Hanwoo has been subjected to intensive selection to improve meat traits. To identify genetic traces driven by recent selection in brown Hanwoo, we scanned the genomes of brown and brindle Hanwoo using a bovine SNP chip. We identified 17 candidate selection signatures in brown Hanwoo and sequenced four candidate regions from 10 individuals each of brown and brindle Hanwoo. In particular, non-synonymous SNPs in the ADSL gene (K88M, L189H, and R302Q) might have had mutational effects on protein structure as a result of altering the purine pathway during nucleotide breakdown. The ADSL gene was previously reported to affect meat quality and yield in livestock. Meat quality and yield are main breeding goals for brown Hanwoo, and our results support a potential causal influence of non-synonymous SNPs in the ADSL gene. [BMB Reports 2016; 49(9): 514-519].
authors.affiliation: Division of Animal Genomics & Bioinformatics, National Institute of Animal Science, RDA, Jeonju 55365, Korea.
authors.forename: Dajeong
authors.initials: D
authors.lastname: Lim
authors.affiliation: Division of Animal Genomics & Bioinformatics, National Institute of Animal Science, RDA, Jeonju 55365, Korea.
authors.forename: Bong Hwan
authors.initials: BH
authors.lastname: Choi
authors.affiliation: Division of Animal Genomics & Bioinformatics, National Institute of Animal Science, RDA, Jeonju 55365, Korea.
authors.forename: Yong Min
authors.initials: YM
authors.lastname: Cho
authors.affiliation: Division of Animal Genomics & Bioinformatics, National Institute of Animal Science, RDA, Jeonju 55365, Korea.
authors.forename: Han Ha
authors.initials: HH
authors.lastname: Chai
authors.affiliation: Division of Animal Genomics & Bioinformatics, National Institute of Animal Science, RDA, Jeonju 55365, Korea.
authors.forename: Gul Won
authors.initials: GW
authors.lastname: Jang
authors.affiliation: School of Environmental and Rural Science, University of New England, Armidale, NSW 2351, Australia.
authors.forename: Cedric
authors.initials: C
authors.lastname: Gondro
authors.affiliation: Hanwoo Department, Korea Animal Improvement Association, Seoul 06668, Korea.
authors.forename: Yeoung Ho
authors.initials: YH
authors.lastname: Jeoung
authors.affiliation: Division of Animal and Dairy Science, Chung Nam National University, Daejeon 34134, Korea.
authors.forename: Seung Hwan
authors.initials: SH
authors.lastname: Lee
mesh_terms: D000264:Adenylosuccinate Lyase / Q000235:genetics; D000818:Animals; D001947:Breeding; D002417:Cattle; D016678:Genome; D005838:Genotype; D006239:Haplotypes; D006720:Homozygote; D008460:Meat / Q000032:analysis; D020641:Polymorphism, Single Nucleotide; D025341:Principal Component Analysis; D056910:Republic of Korea; D017422:Sequence Analysis, DNA
chemical_list: D000264:Adenylosuccinate Lyase