title: A newly developed tracheal tube offering 'pressurised sealing' outperforms currently available tubes in preventing cuff leakage: A benchtop study.
abstract: BACKGROUND
  No currently used tracheal tube offers full protection against aspiration of oropharyngeal secretions into the lower airways.
  
  
  OBJECTIVE
  We developed a tracheal tube equipped with two polyvinylchloride (PVC) cuffs with a supplementary port opening between the cuffs through which a continuous positive pressure of 5 cmH2O is provided [double-cuffed PVC (PVCdc)]. We compared this PVCdc with four different cuff types (cylindrical PVC, conical PVC, cylindrical polyurethane and conical polyurethane).
  
  
  METHODS
  A comparison study using an in-vitro benchtop model of an artificial rigid trachea.
  
  
  METHODS
  Tracheal tubes were placed in the artificial trachea. Both cuffs were kept inflated at 25 cmH2O. Total 3 ml dyed water was placed above the cuff and leakage recorded under static and dynamic [5 cmH2O positive end-expiratory pressure (PEEP) alone or positive pressure ventilation plus 5 cmH2O PEEP] conditions. At the end of the dynamic experiments, PEEP was zeroed (PEEP alone) or the tracheal tubes were disconnected from the ventilator (positive pressure ventilation plus PEEP).
  
  
  RESULTS
  In the static model, leakage flows [medians (range)] were 9.8 (6.2 to 20) for the cylindrical PVC, 1.3 (0.2 to 3.8) for the conical PVC, 0.03 (0.007 to 0.1) for the cylindrical polyurethane, 0.04 (0.003 to 0.2) for the conical polyurethane and 0.0 (0.0 to 0.0) ml min for the PVCdc cuff (P < 0.001, PVCdc vs. all other cuffs). In the dynamic setting, no leakage was detected for up to 60 min with any of the cuffs studied. Loss of PEEP or tracheal tube disconnection resulted in dye inflow alongside all cuffs except for the PVCdc (P < 0.001, PVCdc vs. all other cuffs).
  
  
  CONCLUSIONS
  A 'pressure seal' incorporated in a double-cuffed tracheal tube prevented fluid passage into the lower airways. Clinically, this may translate into absence of inflow of bacteriologically contaminated secretions into the lungs and thus a lower incidence of ventilator-associated infection.
authors.affiliation: From the Intensive Care Department, University Hospital Brussels, Vrije Universiteit Brussel, Brussels, Belgium (HDS, ES, MD, WS, GD, PMH).
authors.forename: Herbert D
authors.initials: HD
authors.lastname: Spapen
authors.forename: Emiel
authors.initials: E
authors.lastname: Suys
authors.forename: Marc
authors.initials: M
authors.lastname: Diltoer
authors.forename: Wim
authors.initials: W
authors.lastname: Stiers
authors.forename: Geert
authors.initials: G
authors.lastname: Desmet
authors.forename: Patrick M
authors.initials: PM
authors.lastname: Honoré
mesh_terms: D004867:Equipment Design / Q000295:instrumentation* / Q000379:methods / Q000592:standards; D007442:Intubation, Intratracheal / Q000295:instrumentation* / Q000379:methods / Q000592:standards; D008422:Materials Testing / Q000295:instrumentation* / Q000592:standards; D008954:Models, Biological; D011143:Polyvinyl Chloride / Q000592:standards; D011175:Positive-Pressure Respiration / Q000295:instrumentation / Q000379:methods / Q000592:standards
chemical_list: D011143:Polyvinyl Chloride