title: [Matrix Gla protein as natural inhibitor of vascular calcification and potential treatment target].
abstract: Vascular calcification was once regarded as an advanced stage of atherosclerosis only. However, calcification is currently considered as highly regulated and potentially reversible process.Matrix Gla protein (MGP) represents natural inhibitor of vascular calcification, whereas vitamin K is key co-factor of its maturation to the active form. There is accumulating evidence that vitamin K status and corresponding MGP activity may influence cardiovascular risk. This review summarizes pathophysiological mechanism and recent evidence relative to MGP. Moreover, available data concerning vitamin K supplementation are depicted.
authors.forename: Otto
authors.initials: O
authors.lastname: Mayer
mesh_terms: D000933:Antifibrinolytic Agents / Q000627:therapeutic use; D002135:Calcium-Binding Proteins / Q000627:therapeutic use*; D019587:Dietary Supplements; D016326:Extracellular Matrix Proteins / Q000627:therapeutic use*; D006801:Humans; D012307:Risk Factors; D061205:Vascular Calcification / Q000517:prevention & control*; D014812:Vitamin K / Q000627:therapeutic use*; D000097568:Matrix Gla Protein
chemical_list: D000933:Antifibrinolytic Agents; D002135:Calcium-Binding Proteins; D016326:Extracellular Matrix Proteins; D014812:Vitamin K; D000097568:Matrix Gla Protein
keywords: cardiovascular diseases.; matrix Gla protein; vascular calcifications; vitamin K