title: Solid variant of orbital angioleiomyoma: An unusual tumor at an unusual site.
abstract: We describe the clinicopathological features of a solid variant of orbital angioleiomyoma. A review of clinical records, diagnostic, and radiographic studies combined with histopathological evaluation with standard histochemical staining and immunohistochemistry was conducted. A 22-year-old male patient presented with a mass in the region of the left lacrimal gland that was gradually increasing over the past 2 years. Radiological and clinical examinations showed no signs suspicious of a malignancy and fine needle aspiration cytology was inconclusive. Therefore, an excision biopsy was performed. On histopathological examination, the picture was consistent with a benign spindle cell tumor. Immunohistochemistry showed positivity for CD 34 and CD 31 (markers for vascular endothelium). The tumor also showed positivity for smooth muscle actin and Ki-67 proliferative index was low. Angioleiomyomas are rarely encountered in the orbit and has features seen in leiomyoma as well as some vascular tumor elements. In most cases, surgical excision is usually curative.
authors.affiliation: Ophthalmic Plastic Surgery and Ocular Oncology Services, Advanced Eye Hospital and Institute, Navi Mumbai, Maharashtra, India.
authors.forename: Akshay Gopinathan
authors.initials: AG
authors.lastname: Nair
authors.affiliation: Ophthalmic Plastic Surgery and Ocular Oncology Services, Advanced Eye Hospital and Institute, Navi Mumbai, Maharashtra, India.
authors.forename: Vandana
authors.initials: V
authors.lastname: Jain
authors.affiliation: Clinico Path Labs, Mumbai, Maharashtra, India.
authors.forename: Indumati
authors.initials: I
authors.lastname: Gopinathan
authors.affiliation: Metropolis Healthcare, Mumbai, Maharashtra, India.
authors.forename: Anuradha
authors.initials: A
authors.lastname: Murthy
mesh_terms: D018229:Angiomyoma / Q000175:diagnosis* / Q000601:surgery; D044963:Biopsy, Fine-Needle; D003937:Diagnosis, Differential; D006801:Humans; D008297:Male; D013508:Ophthalmologic Surgical Procedures; D009918:Orbital Neoplasms / Q000175:diagnosis* / Q000601:surgery; D014057:Tomography, X-Ray Computed; D055815:Young Adult