title: MANAGEMENT OF OSTEOMYELITIS CAUSED BY SALMONELLA ENTERICA SUBSP. HOUTENAE IN A TAYLOR'S CANTIL (AGKISTRODON BILINEATUS TAYLORI) USING AMIKACIN DELIVERED VIA OSMOTIC PUMP.
abstract: An adult female Taylor's cantil (Agkistrodon bilineatus taylori) presented with marked spinal and mandibular osteomyelitis that cultured positive for Salmonella enterica subsp. houtenae, serovar IV 43:z4,z32:-. Progression of osteomyelitis was arrested by treatment using amikacin (0.026 mg/kg per hour) delivered via subcutaneous osmotic pump for 10 mo, replacing the pump every 4 wk. No adverse effects on renal function were appreciated throughout the course of therapy. Amikacin therapy was discontinued after improvement with treatment, but 5 mo later, bony lesions worsened, and an additional abscess formed at the previous pump site. The animal's condition declined and euthanasia was elected. Postmortem examination confirmed marked osteomyelitis with Salmonella infection of same serovar as the initial biopsy. This report highlights the pathogenicity of the S. enterica subsp. houtenae serovar and the ability to deliver effective amikacin dosage via osmotic pump to arrest osteomyelitis due to salmonellosis in a venomous snake.
authors.forename: Meredith M
authors.initials: MM
authors.lastname: Clancy
authors.forename: Alisa L
authors.initials: AL
authors.lastname: Newton
authors.forename: John M
authors.initials: JM
authors.lastname: Sykes
mesh_terms: D017836:Agkistrodon; D000583:Amikacin / Q000008:administration & dosage / Q000627:therapeutic use*; D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000627:therapeutic use; D007260:Infusion Pumps; D010019:Osteomyelitis / Q000188:drug therapy / Q000382:microbiology / Q000662:veterinary*; D011859:Radiography; D012481:Salmonella Infections, Animal / Q000188:drug therapy / Q000382:microbiology*; D019779:Salmonella enterica; D013131:Spine / Q000000981:diagnostic imaging / Q000473:pathology
chemical_list: D000900:Anti-Bacterial Agents; D000583:Amikacin
keywords: Agkistrodon; Salmonella; amikacin; osmotic pump; osteomyelitis; snake