title: Physiochemical basis of human degenerative disease.
abstract: The onset of human degenerative diseases in humans, including type 2 diabetes, cardiovascular disease, neurological disorders, neurodevelopmental disease and neurodegenerative disease has been shown to be related to exposures to persistent organic pollutants, including polychlorinated biphenyls, chlorinated pesticides, polybrominated diphenyl ethers and others, as well as to polynuclear aromatic hydrocarbons, phthalates, bisphenol-A and other aromatic lipophilic species. The onset of these diseases has also been related to exposures to transition metal ions. A physiochemical mechanism for the onset of degenerative environmental disease dependent upon exposure to a combination of lipophilic aromatic hydrocarbons and transition metal ions is proposed here. The findings reported here also, for the first time, explain why aromatic hydrocarbons exhibit greater toxicity than aliphatic hydrocarbons of equal carbon numbers.
authors.affiliation: Zeliger Research and Consulting, Cape Elizabeth, Maine, USA.
authors.forename: Harold I
authors.initials: HI
authors.lastname: Zeliger
authors.affiliation: Harvard Medical School, Joslin Diabetes Center, Boston, Massachusetts, USA.
authors.forename: Boguslaw
authors.initials: B
authors.lastname: Lipinski
keywords: Alzheimer's disease; cancer; degenerative environmental disease; diabetes; membrane permeability; toxicity mechanism