title: Grey matter atrophy in prodromal stage of dementia with Lewy bodies and Alzheimer's disease.
abstract: Little is known about the patterns of brain atrophy in prodromal dementia with Lewy bodies (pro-DLB).
  
  
  
  In this study, we used SPM8 with diffeomorphic anatomical registration through exponentiated lie algebra to measure grey matter (GM) volume and investigate patterns of GM atrophy in pro-DLB (n = 28) and prodromal Alzheimer's disease (pro-AD) (n = 27) and compared and contrasted them with those in elderly control subjects (n = 33) (P ≤ 0.05 corrected for family-wise error).
  
  
  
  Patients with pro-DLB showed diminished GM volumes of bilateral insulae and right anterior cingulate cortex compared with control subjects. Comparison of GM volume between patients with pro-AD and control subjects showed a more extensive pattern, with volume reductions in temporal (hippocampi and superior and middle gyri), parietal and frontal structures in the former. Direct comparison of prodromal groups suggested that more atrophy was evident in the parietal lobes of patients with pro-AD than patients with pro-DLB. In patients with pro-DLB, we found that visual hallucinations were associated with relative atrophy of the left cuneus.
  
  
  
  Atrophy in pro-DLB involves the insulae and anterior cingulate cortex, regions rich in von Economo neurons, which we speculate may contribute to the early clinical phenotype of pro-DLB.
authors.affiliation: Geriatrics day hospital and neuropsychology unit. Geriatrics department and Neurology service, Memory Resources and Research Centre (CMRR), University Hospital of Strasbourg, Strasbourg, France. f.blanc@unistra.fr.|Team IMIS/Neurocrypto, French National Center for Scientific Research (CNRS), ICube Laboratory and Fédération de Médecine Translationnelle de Strasbourg (FMTS), University of Strasbourg, Strasbourg, France. f.blanc@unistra.fr.|Institute of Neuroscience, Campus for Aging and Vitality, Newcastle University, Newcastle upon Tyne, UK. f.blanc@unistra.fr.
authors.forename: Frederic
authors.identifier: 0000-0002-6714-3247
authors.initials: F
authors.lastname: Blanc
authors.affiliation: Institute of Neuroscience, Campus for Aging and Vitality, Newcastle University, Newcastle upon Tyne, UK.
authors.forename: Sean J
authors.initials: SJ
authors.lastname: Colloby
authors.affiliation: Geriatrics day hospital and neuropsychology unit. Geriatrics department and Neurology service, Memory Resources and Research Centre (CMRR), University Hospital of Strasbourg, Strasbourg, France.|Team IMIS/Neurocrypto, French National Center for Scientific Research (CNRS), ICube Laboratory and Fédération de Médecine Translationnelle de Strasbourg (FMTS), University of Strasbourg, Strasbourg, France.
authors.forename: Benjamin
authors.initials: B
authors.lastname: Cretin
authors.affiliation: Team IMIS/Neurocrypto, French National Center for Scientific Research (CNRS), ICube Laboratory and Fédération de Médecine Translationnelle de Strasbourg (FMTS), University of Strasbourg, Strasbourg, France.
authors.forename: Paulo Loureiro
authors.initials: PL
authors.lastname: de Sousa
authors.affiliation: Geriatrics day hospital and neuropsychology unit. Geriatrics department and Neurology service, Memory Resources and Research Centre (CMRR), University Hospital of Strasbourg, Strasbourg, France.
authors.forename: Catherine
authors.initials: C
authors.lastname: Demuynck
authors.affiliation: Institute of Neuroscience, Campus for Aging and Vitality, Newcastle University, Newcastle upon Tyne, UK.|Department of Psychiatry, University of Cambridge, Cambridge Biomedical Campus, Cambridge, UK.
authors.forename: John T
authors.initials: JT
authors.lastname: O'Brien
authors.affiliation: Geriatrics day hospital and neuropsychology unit. Geriatrics department and Neurology service, Memory Resources and Research Centre (CMRR), University Hospital of Strasbourg, Strasbourg, France.
authors.forename: Catherine
authors.initials: C
authors.lastname: Martin-Hunyadi
authors.affiliation: Institute of Neuroscience, Campus for Aging and Vitality, Newcastle University, Newcastle upon Tyne, UK.
authors.forename: Ian
authors.initials: I
authors.lastname: McKeith
authors.affiliation: Geriatrics day hospital and neuropsychology unit. Geriatrics department and Neurology service, Memory Resources and Research Centre (CMRR), University Hospital of Strasbourg, Strasbourg, France.|Team IMIS/Neurocrypto, French National Center for Scientific Research (CNRS), ICube Laboratory and Fédération de Médecine Translationnelle de Strasbourg (FMTS), University of Strasbourg, Strasbourg, France.
authors.forename: Nathalie
authors.initials: N
authors.lastname: Philippi
authors.affiliation: Institute of Neuroscience, Campus for Aging and Vitality, Newcastle University, Newcastle upon Tyne, UK.
authors.forename: John-Paul
authors.initials: JP
authors.lastname: Taylor
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000000981:diagnostic imaging*; D001284:Atrophy / Q000000981:diagnostic imaging; D001921:Brain / Q000000981:diagnostic imaging*; D005260:Female; D066128:Gray Matter / Q000000981:diagnostic imaging*; D006801:Humans; D021621:Imaging, Three-Dimensional; D020961:Lewy Body Disease / Q000000981:diagnostic imaging*; D008279:Magnetic Resonance Imaging; D008297:Male; D009929:Organ Size; D062706:Prodromal Symptoms; D012044:Regression Analysis
keywords: Alzheimer’s dementia; Alzheimer’s disease; Dementia with Lewy bodies; Insula; Lewy body disease; MRI; Mild cognitive impairment; Prodromal Alzheimer’s disease; Prodromal dementia with Lewy bodies