title: Construction of Electrochemical Chiral Interfaces with Integrated Polysaccharides via Amidation.
abstract: Polysaccharides of sodium carboxymethyl cellulose (CMC) and chitosan (CS) were integrated together via amidation reactions between the carboxyl groups on sodium CMC and the amino groups on CS. Compared with individual sodium CMC and CS, the integrated polysaccharides with a mass ratio of 1:1, CMC-CS (1:1), exhibited a three-dimensional (3D) porous network structure, resulting in a significantly enhanced hydrophility due to the exposed polar functional groups in the CMC-CS (1:1). Chiral interfaces were constructed with the integrated polysaccharides and used for electrochemical enantiorecognition of tryptophan (Trp) isomers. The CMC-CS (1:1) chiral interfaces exhibited excellent selectivity toward the Trp isomers owing to the highly hydrophilic feature of CMC-CS (1:1) and the different steric hindrance during the formation of H bonds between Trp isomers and CMC-CS (1:1). Also, the optimization in the preparation of integrated polysaccharides such as mass ratio and combination mode (amidation or electrostatic interactions) was investigated. The CMC-CS (1:1) presented the ability of determining the percentage of d-Trp in racemic mixtures, and thus, the proposed electrochemical chiral interfaces could be regarded as a potential biosensing platform for enantiorecognition of chiral compounds.
authors.affiliation: Jiangsu Key Laboratory of Advanced Catalytic Materials and Technology, School of Petrochemical Engineering, Changzhou University , Changzhou 213164, China.
authors.forename: Liping
authors.initials: L
authors.lastname: Bao
authors.affiliation: School of Chemistry and Material Engineering, Changzhou Vocational Institute of Engineering , Changzhou 213164, China.
authors.forename: Xiaohui
authors.initials: X
authors.lastname: Chen
authors.affiliation: Jiangsu Key Laboratory of Advanced Catalytic Materials and Technology, School of Petrochemical Engineering, Changzhou University , Changzhou 213164, China.
authors.forename: Baozhu
authors.initials: B
authors.lastname: Yang
authors.affiliation: Jiangsu Key Laboratory of Advanced Catalytic Materials and Technology, School of Petrochemical Engineering, Changzhou University , Changzhou 213164, China.
authors.forename: Yongxin
authors.initials: Y
authors.lastname: Tao
authors.affiliation: Jiangsu Key Laboratory of Advanced Catalytic Materials and Technology, School of Petrochemical Engineering, Changzhou University , Changzhou 213164, China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Kong
keywords: amidation; chiral interfaces; integrated polysaccharides; three-dimensional porous structure; tryptophan isomers