title: Cognitive Reserve and the Prevention of Dementia: the Role of Physical and Cognitive Activities.
abstract: The article discusses the two most significant modifiable risk factors for dementia, namely, physical inactivity and lack of stimulating cognitive activity, and their effects on developing cognitive reserve.
  
  
  
  Both of these leisure-time activities were associated with significant reductions in the risk of dementia in longitudinal studies. In addition, physical activity, particularly aerobic exercise, is associated with less age-related gray and white matter loss and with less neurotoxic factors. On the other hand, cognitive training studies suggest that training for executive functions (e.g., working memory) improves prefrontal network efficiency, which provides support to brain functioning in the face of cognitive decline. While physical activity preserves neuronal structural integrity and brain volume (hardware), cognitive activity strengthens the functioning and plasticity of neural circuits (software), thus supporting cognitive reserve in different ways. Future research should examine whether lifestyle interventions incorporating these two domains can reduce incident dementia.
authors.affiliation: Department of Health and Physical Education, The Education University of Hong Kong, 10 Lo Ping Road, Tai Po, N.T., Hong Kong. takcheng@eduhk.hk.|Department of Clinical Psychology, Norwich Medical School, University of East Anglia, Norfolk, NR4 7TJ, UK. takcheng@eduhk.hk.
authors.forename: Sheung-Tak
authors.initials: ST
authors.lastname: Cheng
mesh_terms: D003071:Cognition / Q000502:physiology*; D058245:Cognitive Reserve / Q000502:physiology*; D003704:Dementia / Q000503:physiopathology / Q000517:prevention & control / Q000523:psychology; D015444:Exercise / Q000523:psychology*; D006801:Humans; D007858:Learning; D008019:Life Style
keywords: Cognitive activity; Cognitive reserve; Dementia; Physical activity