title: The effects of preoperative oral antibiotic use on the development of surgical site infection after elective colorectal resections: A retrospective cohort analysis in consecutively operated 90 patients.
abstract: OBJECTIVE
  The influence of oral antibiotic use together with mechanical bowel preparation (MBP) on surgical site infection (SSI) rate, length of hospital stay and total hospital costs in patients undergoing elective colorectal surgery were evaluated in this study.
  
  
  METHODS
  Data from 90 consecutive patients undergoing elective colorectal resection between October 2006 and September 2009 was analyzed retrospectively. All patients received MBP. Patients in group A were given oral antibiotics (a total 480 mg of gentamycin, 4 gr of metronidazole in two divided doses and 2 mg of bisacodyl PO), whereas patients in group B received no oral antibiotics. Exclusion criteria were emergent operations, laparoscopic operations, preoperative chemoradiotherapy, intraoperative colonoscopy prior to the creation of an anastomosis or antibiotic use within the previous 10 days. SSI, length of hospital stays and total hospital charges were evaluated.
  
  
  RESULTS
  Patients in both study groups, group A (n = 45) and group B (n = 45), were similar in terms of age, BMI, diverting ileostomy creation, localization and stage of the disease. Patients receiving oral antibiotics demonstrated a lower rate of wound infections (36% vs. 71%, p < 0.001), shorter hospital stay (8.1 ± 2.4 days vs. 14.2 ± 10.9 days, respectively, p < 0.001) and similar rates for anastomotic leakage (2% vs. 11%, p = 0.20). The mean ± SD total hospital charges were significantly lower in Group A (2.699 ± 0.892$) than that in Group B (4.411 ± 4.995$, p = 0.029).
  
  
  CONCLUSIONS
  Preoperative oral antibiotic use with MBP may provide faster recovery with less SSI and hospital charges.
authors.affiliation: Department of Surgery, Ufuk University, Ankara, Turkey. Electronic address: szdmir71@gmail.com.
authors.forename: Suleyman
authors.initials: S
authors.lastname: Ozdemir
authors.affiliation: Department of Surgery, Ufuk University, Ankara, Turkey.
authors.forename: Kamil
authors.initials: K
authors.lastname: Gulpinar
authors.affiliation: Department of Surgery, Ufuk University, Ankara, Turkey.
authors.forename: S Erpulat
authors.initials: SE
authors.lastname: Ozis
authors.affiliation: Department of Surgery, Ufuk University, Ankara, Turkey.
authors.forename: Zafer
authors.initials: Z
authors.lastname: Sahli
authors.affiliation: Department of Surgery, Ufuk University, Ankara, Turkey.
authors.forename: S Altug
authors.initials: SA
authors.lastname: Kesikli
authors.affiliation: Department of Surgery, Ufuk University, Ankara, Turkey.
authors.forename: Atila
authors.initials: A
authors.lastname: Korkmaz
authors.affiliation: Department of Surgery, University of Ankara, Turkey.
authors.forename: I Ethem
authors.initials: IE
authors.lastname: Gecim
mesh_terms: D000284:Administration, Oral; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D057868:Anastomotic Leak / Q000453:epidemiology; D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D019072:Antibiotic Prophylaxis; D003082:Colectomy / Q000009:adverse effects*; D003093:Colitis, Ulcerative / Q000601:surgery*; D003110:Colonic Neoplasms / Q000601:surgery*; D017558:Elective Surgical Procedures / Q000009:adverse effects; D005260:Female; D017721:Hospital Costs; D006801:Humans; D007902:Length of Stay; D008297:Male; D008795:Metronidazole / Q000008:administration & dosage; D008875:Middle Aged; D011300:Preoperative Care; D012189:Retrospective Studies; D013530:Surgical Wound Infection / Q000453:epidemiology* / Q000517:prevention & control; D055815:Young Adult
chemical_list: D000900:Anti-Bacterial Agents; D008795:Metronidazole
keywords: Colorectal resection; Oral antibiotic prophylaxis; Surgical site infection