title: Chromosome 14 Abnormality with a Breakpoint of p12 in Adult T-cell Leukemia.
abstract: We describe a patient with adult T-cell leukemia (ATL) with a 14p chromosomal abnormality. Cytogenetic study revealed two clonal populations of leukemic cells in the peripheral blood sample. Both clones were karyotypically related to each other. One of them showed rearrangement of chromosome 14 at break band p 12 (14p12) in addition to + 3, + 7, -X and del(6) (q14q21). The nucleolar organizer region (NOR) is assigned to the band 14p12 and the role of the rearrangement of chromosome 14p12 in the pathogenesis of ATL is discussed.
authors.affiliation: a Second Department of Medicine, Kyoto Prefectural University of Medicine, Kawaramachi-Hirokoji, Kamikyo-ku, Kyoto, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Itoh
authors.affiliation: a Second Department of Medicine, Kyoto Prefectural University of Medicine, Kawaramachi-Hirokoji, Kamikyo-ku, Kyoto, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Oku
authors.affiliation: a Second Department of Medicine, Kyoto Prefectural University of Medicine, Kawaramachi-Hirokoji, Kamikyo-ku, Kyoto, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Gotoh
authors.affiliation: a Second Department of Medicine, Kyoto Prefectural University of Medicine, Kawaramachi-Hirokoji, Kamikyo-ku, Kyoto, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Inaba
authors.affiliation: a Second Department of Medicine, Kyoto Prefectural University of Medicine, Kawaramachi-Hirokoji, Kamikyo-ku, Kyoto, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Murakami
authors.affiliation: a Second Department of Medicine, Kyoto Prefectural University of Medicine, Kawaramachi-Hirokoji, Kamikyo-ku, Kyoto, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Oku
authors.affiliation: a Second Department of Medicine, Kyoto Prefectural University of Medicine, Kawaramachi-Hirokoji, Kamikyo-ku, Kyoto, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Takeda
authors.affiliation: a Second Department of Medicine, Kyoto Prefectural University of Medicine, Kawaramachi-Hirokoji, Kamikyo-ku, Kyoto, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Ura
authors.affiliation: a Second Department of Medicine, Kyoto Prefectural University of Medicine, Kawaramachi-Hirokoji, Kamikyo-ku, Kyoto, Japan.
authors.forename: C
authors.initials: C
authors.lastname: Shimazaki
authors.affiliation: a Second Department of Medicine, Kyoto Prefectural University of Medicine, Kawaramachi-Hirokoji, Kamikyo-ku, Kyoto, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Nakanishi
authors.affiliation: a Second Department of Medicine, Kyoto Prefectural University of Medicine, Kawaramachi-Hirokoji, Kamikyo-ku, Kyoto, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Haruyama
authors.affiliation: a Second Department of Medicine, Kyoto Prefectural University of Medicine, Kawaramachi-Hirokoji, Kamikyo-ku, Kyoto, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Nakagawa
authors.affiliation: b Department of Laboratory Medicine, Kyoto Prefectural University of Medicine, Kawaramachi-Hirokoji, Kamikyo-ku, Kyoto, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Fujita
authors.affiliation: c Third Department of Medicine, Kyoto Prefectural University of Medicine, Kawaramachi-Hirokoji, Kamikyo-ku, Kyoto, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Taniwaki
keywords: 14p12; Adult T-cell leukemia; Breakpoint; Chromosome abnormality; Nucleolar organizer region