title: Corticosteroids as an adjunct to propranolol for infantile haemangiomas complicated by recalcitrant ulceration.
abstract: A small subset of patients with infantile haemangiomas (IHs) can present with serious complications, the most common of which is ulceration. Ulcerated IHs can be extremely painful and always result in scarring. Numerous studies support the efficacy and reduced side-effects of propranolol relative to systemic corticosteroids, which led to the adoption of propranolol as the mainstay of IH treatment. However, in certain cases of IH with complex ulceration, propranolol monotherapy may not be sufficient. In this case report, we present two cases that illustrate the effectiveness of the adjunctive use of oral corticosteroids for the treatment of select IHs with recalcitrant painful ulceration, which were refractory to conservative wound care, laser therapy and oral propranolol. We suggest a continuing niche role for the brief use of corticosteroids as an effective adjunct to oral propranolol in managing a subset of complex IHs complicated by intractable ulceration.
authors.affiliation: Department of Dermatology, Division of Pediatric Dermatology, Johns Hopkins University School of Medicine, 200 North Wolfe Street, Unit 2107, Baltimore, 21287, MD, U.S.A.
authors.forename: E
authors.initials: E
authors.lastname: Lie
authors.affiliation: Department of Dermatology, Division of Pediatric Dermatology, Johns Hopkins University School of Medicine, 200 North Wolfe Street, Unit 2107, Baltimore, 21287, MD, U.S.A.
authors.forename: K B
authors.initials: KB
authors.lastname: Püttgen
mesh_terms: D000284:Administration, Oral; D002908:Chronic Disease; D004359:Drug Therapy, Combination; D005938:Glucocorticoids / Q000008:administration & dosage*; D006391:Hemangioma / Q000150:complications / Q000188:drug therapy*; D006801:Humans; D007223:Infant; D008297:Male; D011239:Prednisolone / Q000008:administration & dosage; D011433:Propranolol / Q000008:administration & dosage*; D012878:Skin Neoplasms / Q000150:complications / Q000188:drug therapy*; D012883:Skin Ulcer / Q000188:drug therapy / Q000209:etiology*; D016896:Treatment Outcome; D014665:Vasodilator Agents / Q000008:administration & dosage*
chemical_list: D005938:Glucocorticoids; D014665:Vasodilator Agents; D011239:Prednisolone; D011433:Propranolol