title: BCR-ABL transcript variations in chronic phase chronic myelogenous leukemia patients on imatinib first-line: Possible role of the autologous immune system.
abstract: Many chronic myelogenous leukemia (CML) patients in chronic phase who respond well to imatinib therapy show fluctuations in their leukemic loads in the long-term. We developed a mathematical model of CML that incorporates the intervention of an autologous immune response. Our results suggest that the patient's immune system plays a crucial role in imatinib therapy in maintaining disease control over time. The observed BCR-ABL/ABL oscillations in such patients provide a signature of the autologous immune response.
authors.affiliation: Department of Mathematics and Center for Scientific Computation and Mathematical Modeling (CSCAMM), University of Maryland , College Park, MD, USA.
authors.forename: Geoffrey D
authors.initials: GD
authors.lastname: Clapp
authors.affiliation: Inria, and Université de Lyon, Université Claude Bernard Lyon, CNRS UMR 5208, Institute Camille Jordan , Villeurbanne Cedex, France.
authors.forename: Thomas
authors.initials: T
authors.lastname: Lepoutre
authors.affiliation: Hematology Department 1G, Center Hospatlier Lyon, Sud, Pierre-Bénite, France and INSERM U1052, CRCL, Center Léon Bérard , Lyon, France.
authors.forename: Franck E
authors.initials: FE
authors.lastname: Nicolini
authors.affiliation: Department of Mathematics and Center for Scientific Computation and Mathematical Modeling (CSCAMM), University of Maryland , College Park, MD, USA.
authors.forename: Doron
authors.initials: D
authors.lastname: Levy
keywords: Chronic myelogenous leukemia; TKI; imatinib; mathematical modeling