title: Ceanothane-type triterpenoids from Cyphostemma adenocaule.
abstract: Phytochemical investigation of the methanol extract of Cyphostemma adenocaule liana (bark and wood) led to the isolation of two new ceanothane-type triterpenoids, cyphostemmic acid A 1 and cyphostemmic acid B 2, together with the known triterpenoids 3-7, β-sitosterol and its glucoside. The structures of the isolated compounds were established by 1D- and 2D-NMR spectroscopy. Ozonolysis of cyphostemmic acid A 1, epigouanic acid A 3 and betulin 6 yielded semisynthetic derivatives, cyphostemmic acid C 8, cyphostemmic acid D 9, and 3β,28-dihydroxy-30-norlupan-20-one 10 respectively. Compounds 1-4, 6, 8-10 were tested in vitro, for their antiplasmodial activity against Plasmodium falciparum 3D7 strain and showed weak activity.
authors.affiliation: Department of Chemistry, Faculty of Science, University of Dschang, P.O. Box 67, Dschang, Cameroon.
authors.forename: Jean Rodolphe
authors.initials: JR
authors.lastname: Chouna
authors.affiliation: Laboratoire d'Innovation Thérapeutique, UMR7200 CNRS/Université de Strasbourg, Labex Médalis, Faculté de Pharmacie, 74 Route du Rhin, 67412, Illkirch, France.|Institut de Parasitologie et de Pathologie Tropicale, EA 7292 Dynamique des Intercations Hôte-Pathogènes, Faculté de Médecine, 3 rue Koberlé, 67000, Strasbourg, France.
authors.forename: Flore
authors.initials: F
authors.lastname: Nardella
authors.affiliation: Department of Chemistry, Higher Teacher Training College, University of Yaoundé 1, P.O. Box 47, Yaoundé, Cameroon.
authors.forename: Bruno Ndjakou
authors.initials: BN
authors.lastname: Lenta
authors.affiliation: Laboratoire d'Innovation Thérapeutique, UMR7200 CNRS/Université de Strasbourg, Labex Médalis, Faculté de Pharmacie, 74 Route du Rhin, 67412, Illkirch, France.
authors.forename: Catherine
authors.initials: C
authors.lastname: Vonthron-Sénécheau
authors.affiliation: Department of Chemistry, Faculty of Science, University of Dschang, P.O. Box 67, Dschang, Cameroon. pnfalango@yahoo.fr.
authors.forename: Pépin
authors.initials: P
authors.lastname: Nkeng-Efouet-Alango
authors.affiliation: Organic and Bioorganic Chemistry, Department of Chemistry, Bielefeld University, P.O. Box 100131, 33501, Bielefeld, Germany.
authors.forename: Norbert
authors.initials: N
authors.lastname: Sewald
keywords: Antiplasmodial; Ceanothane-type triterpenoids; Cyphostemma adenocaule; Vitaceae