title: Single-agent cytarabine is insufficient for the treatment of human mantle cell lymphoma in mouse xenograft model.
abstract: Mantle cell lymphoma is an aggressive type of B-cell non-Hodgkin lymphoma with adverse prognosis. It was demonstrated that alternation of CHOP and DHAP chemotherapy improved outcome of mantle cell lymphoma patients. However, which components of DHAP, cisplatin, cytarabine, or both, were responsible for the improved outcome remained unclear. To answer this question, antitumor efficacies of equally toxic doses of cytarabine, cisplatin, and three different combinations were compared in vivo using mouse xenograft models of mantle cell lymphoma. We demonstrated that cisplatin, alone or with cytarabine, is significantly superior to single-agent cytarabine in both eliminating lymphoma cells and suppressing their proliferation rate.
authors.forename: M
authors.initials: M
authors.lastname: Klanova
authors.forename: T
authors.initials: T
authors.lastname: Soukup
authors.forename: J
authors.initials: J
authors.lastname: Molinsky
authors.forename: L
authors.initials: L
authors.lastname: Lateckova
authors.forename: P
authors.initials: P
authors.lastname: Vockova
authors.forename: M
authors.initials: M
authors.lastname: Alam
authors.forename: J
authors.initials: J
authors.lastname: Zivny
authors.forename: M
authors.initials: M
authors.lastname: Trneny
authors.forename: P
authors.initials: P
authors.lastname: Klener
mesh_terms: D000818:Animals; D000964:Antimetabolites, Antineoplastic / Q000627:therapeutic use*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D002945:Cisplatin / Q000627:therapeutic use*; D003520:Cyclophosphamide / Q000627:therapeutic use; D003561:Cytarabine / Q000627:therapeutic use*; D003907:Dexamethasone / Q000627:therapeutic use; D004195:Disease Models, Animal; D004317:Doxorubicin / Q000627:therapeutic use; D006801:Humans; D020522:Lymphoma, Mantle-Cell / Q000188:drug therapy* / Q000473:pathology; D051379:Mice; D016688:Mice, Inbred NOD; D016513:Mice, SCID; D011241:Prednisone / Q000627:therapeutic use; D016896:Treatment Outcome; D014750:Vincristine / Q000627:therapeutic use; D023041:Xenograft Model Antitumor Assays
chemical_list: D000964:Antimetabolites, Antineoplastic; D003561:Cytarabine; D014750:Vincristine; D003907:Dexamethasone; D004317:Doxorubicin; D003520:Cyclophosphamide; D002945:Cisplatin; D011241:Prednisone
keywords: DHAP.; cisplatin; high-dose cytarabin; mantle cell lymphoma (MCL)