title: [Endoscopic treatment of 140 pituitary tumors, results and complications].
abstract: OBJECTIVE
  To present the clinical and radiographic outcomes of 140 patients with pituitary adenomas treated by an endoscopic endonasal approach (EEA) over a period of 4 years.
  
  
  METHODS
  A retrospective analysis was performed between 2011 and 2014. Pre and post operative MRI, ophtalmological assessment, endocrinological laboratory evaluation and surgical morbidity and mortality were assessed.
  
  
  RESULTS
  57,9% of the patients had functional tumors (n=81), acromegaly being the most frequent sub-type (29.3%). 78.6% of the lesions were macroadenomas (n=110) of which 56.4% (n=62) involved the cavernous sinus, 61 patients presented with visual field defects (44%) of which 50.8% of patients showed improvement after surgery. Gross total removal was achieved in 60% of the cases. Hormonal remission was achieved in the 75% of the patients with functional tumors. The morbidity rate was 15% and one patient died after surgery (mortality 0.7%).
  
  
  CONCLUSIONS
  EEA is a safe and effective tool to treat pituitary adenomas. The main limitation for complete surgical resection is the cavernous sinus invasion.
authors.affiliation: Servicio de Neurocirugía, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina.
authors.forename: Sofia
authors.initials: S
authors.lastname: Beltrame
authors.affiliation: Servicio de Neurocirugía, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina.
authors.forename: Maximiliano
authors.initials: M
authors.lastname: Toscano
authors.affiliation: Department of Neurological Surgery, University of Pittsburgh, Pensylvania, Estados Unidos.
authors.forename: Ezequiel
authors.initials: E
authors.lastname: Goldschmidt
authors.affiliation: Servicio de Neurocirugía, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina.
authors.forename: Lucas
authors.initials: L
authors.lastname: Garategui
authors.affiliation: Servicio de Neurocirugía, Hospital Padilla, Tucumán, Argentina.
authors.forename: Alvaro
authors.initials: A
authors.lastname: Campero
authors.affiliation: Servicio de Neurocirugía, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina.
authors.forename: Claudio
authors.initials: C
authors.lastname: Yampolsky
authors.affiliation: Servicio de Neurocirugía, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina.
authors.forename: Antonio
authors.initials: A
authors.lastname: Carrizo
authors.affiliation: Servicio de Neurocirugía, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina. Electronic address: pablo.ajler@hospitalitaliano.org.ar.
authors.forename: Pablo
authors.initials: P
authors.lastname: Ajler
mesh_terms: D000236:Adenoma / Q000000981:diagnostic imaging / Q000601:surgery; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D005500:Follow-Up Studies; D020249:Hormone Replacement Therapy; D006801:Humans; D007018:Hypopituitarism / Q000188:drug therapy / Q000209:etiology; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009296:Nasal Cavity; D057605:Natural Orifice Endoscopic Surgery / Q000379:methods*; D010911:Pituitary Neoplasms / Q000150:complications / Q000000981:diagnostic imaging / Q000453:epidemiology / Q000601:surgery*; D011183:Postoperative Complications / Q000209:etiology; D012086:Reoperation; D012189:Retrospective Studies; D013101:Sphenoid Sinus / Q000601:surgery; D016896:Treatment Outcome; D014786:Vision Disorders / Q000209:etiology; D014794:Visual Fields; D055815:Young Adult
keywords: Adenomas de hipófisis; Endoscopia; Endoscopy; Pituitary adenomas; Transnasal