title: Insulin sensitivity, body composition and adipose depots following 12 w combined endurance and strength training in dysglycemic and normoglycemic sedentary men.
abstract: BACKGROUND
  Insulin resistance and dysglycemia are associated with physical inactivity and adiposity, and may be improved by exercise.
  
  
  OBJECTIVE
  Investigate the effect of exercise on insulin sensitivity, body composition and adipose depots in sedentary men with (n = 11) or without (n = 11) overweight and dysglycemia.
  
  
  METHODS
  Euglycemic-hyperinsulinemic clamp, ankle-to-neck MRI, MRS, muscle and adipose tissue biopsies before and after 12 weeks combined strength and endurance exercise.
  
  
  RESULTS
  Insulin sensitivity, VO2max, strength, whole-body and muscle fat content, and abdominal adipose depots were improved without obvious differences between normo- and dysglycemic men. Hepatic fat, waist circumference and subcutaneous adipose tissue were reduced in the dysglycemic group. For both groups plasma adiponectin was reduced, whereas IL-6 was unchanged. Visceral fat was preferentially lost compared with other adipose depots.
  
  
  CONCLUSIONS
  Body composition, fat distribution and insulin sensitivity improved following training in sedentary middle-aged men with and without dysglycemia.
authors.affiliation: a Department of Nutrition , University of Oslo , Oslo , Norway.|b Department of Endocrinology , Morbid Obesity and Preventive Medicine, Oslo University Hospital , Oslo , Norway.
authors.forename: Torgrim Mikal
authors.initials: TM
authors.lastname: Langleite
authors.affiliation: c Department of Physical Performance , Norwegian School of Sport Sciences , Oslo , Norway.
authors.forename: Jørgen
authors.initials: J
authors.lastname: Jensen
authors.affiliation: a Department of Nutrition , University of Oslo , Oslo , Norway.
authors.forename: Frode
authors.initials: F
authors.lastname: Norheim
authors.affiliation: b Department of Endocrinology , Morbid Obesity and Preventive Medicine, Oslo University Hospital , Oslo , Norway.
authors.forename: Hanne Løvdal
authors.initials: HL
authors.lastname: Gulseth
authors.affiliation: c Department of Physical Performance , Norwegian School of Sport Sciences , Oslo , Norway.
authors.forename: Daniel Steensen
authors.initials: DS
authors.lastname: Tangen
authors.affiliation: c Department of Physical Performance , Norwegian School of Sport Sciences , Oslo , Norway.
authors.forename: Kristoffer Jensen
authors.initials: KJ
authors.lastname: Kolnes
authors.affiliation: b Department of Endocrinology , Morbid Obesity and Preventive Medicine, Oslo University Hospital , Oslo , Norway.|d Institute of Clinical Medicine, Faculty of Medicine, University of Oslo , Oslo , Norway.
authors.forename: Ansgar
authors.initials: A
authors.lastname: Heck
authors.affiliation: e The Intervention Centre, Oslo University Hospital , Oslo , Norway.
authors.forename: Tryggve
authors.initials: T
authors.lastname: Storås
authors.affiliation: c Department of Physical Performance , Norwegian School of Sport Sciences , Oslo , Norway.
authors.forename: Guro
authors.initials: G
authors.lastname: Grøthe
authors.affiliation: c Department of Physical Performance , Norwegian School of Sport Sciences , Oslo , Norway.
authors.forename: Marius Adler
authors.initials: MA
authors.lastname: Dahl
authors.affiliation: a Department of Nutrition , University of Oslo , Oslo , Norway.
authors.forename: Anders
authors.initials: A
authors.lastname: Kielland
authors.affiliation: a Department of Nutrition , University of Oslo , Oslo , Norway.
authors.forename: Torgeir
authors.initials: T
authors.lastname: Holen
authors.affiliation: f Department of Radiology , Oslo University Hospital , Oslo , Norway.
authors.forename: Hans Jørgen
authors.initials: HJ
authors.lastname: Noreng
authors.affiliation: c Department of Physical Performance , Norwegian School of Sport Sciences , Oslo , Norway.
authors.forename: Hans Kristian
authors.initials: HK
authors.lastname: Stadheim
authors.affiliation: e The Intervention Centre, Oslo University Hospital , Oslo , Norway.|g Department of Physics , University of Oslo , Oslo , Norway , and.
authors.forename: Atle
authors.initials: A
authors.lastname: Bjørnerud
authors.affiliation: c Department of Physical Performance , Norwegian School of Sport Sciences , Oslo , Norway.
authors.forename: Egil Ivar
authors.initials: EI
authors.lastname: Johansen
authors.affiliation: c Department of Physical Performance , Norwegian School of Sport Sciences , Oslo , Norway.|h Department of Endocrinology and Internal Medicine , Aarhus University Hospital , Aarhus , Denmark.
authors.forename: Birgitte
authors.initials: B
authors.lastname: Nellemann
authors.affiliation: b Department of Endocrinology , Morbid Obesity and Preventive Medicine, Oslo University Hospital , Oslo , Norway.|d Institute of Clinical Medicine, Faculty of Medicine, University of Oslo , Oslo , Norway.
authors.forename: Kåre Inge
authors.initials: KI
authors.lastname: Birkeland
authors.affiliation: a Department of Nutrition , University of Oslo , Oslo , Norway.
authors.forename: Christian A
authors.initials: CA
authors.lastname: Drevon
mesh_terms: D050154:Adiposity; D000328:Adult; D000368:Aged; D001823:Body Composition; D016022:Case-Control Studies; D015444:Exercise; D006801:Humans; D006943:Hyperglycemia / Q000503:physiopathology*; D007003:Hypoglycemia / Q000503:physiopathology*; D007333:Insulin Resistance; D008297:Male; D008875:Middle Aged; D055070:Resistance Training
keywords: Adipokines; muscle fat; myokines; prediabetes; visceral fat