title: A Review on Pharmacological Properties of Coumarins.
abstract: The coumarin (benzopyran-2-one, or chromen-2-one) ring system, present in many natural products, displays diverse pharmacological properties. It has attracted the attention of chemists and medicinal chemists for decades. Many molecules based on the coumarin ring system have been described utilizing innovative synthetic methods. These synthetic routes have led to interesting analogues of coumarins which possess pharmacological activities like anti-HIV, antimicrobial, antiinflammatory, anticancer, anti-TB, anticonvulsant and MAO inhibitory properties. Details of these studies, correlating structure with biological activity are described in this review.
authors.affiliation: Department of Chemistry, Jawaharlal Nehru Technological University College of Engineering, Kukatpally, Hyderabad 500 085. India.
authors.forename: Devulapally
authors.initials: D
authors.lastname: Srikrishna
authors.affiliation: Department of Regulatory Toxicology, National Institute of Pharmaceutical Education and Research, Balanagar, Hyderabad 500 037. India.
authors.forename: Chandraiah
authors.initials: C
authors.lastname: Godugu
authors.affiliation: Department of Chemistry, Jawaharlal Nehru Technological University College of Engineering, Kukatpally, Hyderabad 500 085. India.
authors.forename: Pramod Kumar
authors.initials: PK
authors.lastname: Dubey
mesh_terms: D000818:Animals; D019380:Anti-HIV Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D000890:Anti-Infective Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D000927:Anticonvulsants / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D000972:Antineoplastic Agents, Phytogenic / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D000995:Antitubercular Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D003374:Coumarins / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D008996:Monoamine Oxidase Inhibitors / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology
chemical_list: D019380:Anti-HIV Agents; D000890:Anti-Infective Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D000927:Anticonvulsants; D000972:Antineoplastic Agents, Phytogenic; D000995:Antitubercular Agents; D003374:Coumarins; D008996:Monoamine Oxidase Inhibitors
keywords: Anticancer; MAO inhibitory; anti-inflammatory; anticonvulsant; antimicrobial; antioxidant; coumarin; pharmacological
  properties