title: Anti-inflammatory and Anti-oxidative Effects of Dexpanthenol on Lipopolysaccharide Induced Acute Lung Injury in Mice.
abstract: The aim of this study is to investigate the effects of dexpanthenol in a model of acute lung injury (ALI) induced by lipopolysaccharides (LPS). Lung injury was induced by exposure to atomized LPS. Mice were randomly divided into four groups: control group; Dxp (500 mg/kg) group; LPS group; LPS + Dxp (500 mg/kg) group. The effects of dexpanthenol on LPS-induced neutrophil recruitment, cytokine levels, total protein concentration, myeloperoxidase (MPO), malondialdehyde (MDA), superoxide dismutase (SOD), and glutathione (GSH) contents were examined. Additionally, lung tissue was examined by histology to investigate the changes in pathology in the presence and absence of dexpanthenol. In LPS-challenged mice, dexpanthenol significantly improved lung edema. Dexpanthenol also markedly inhibited the LPS-induced neutrophiles influx, protein leakage, and release of TNF-α and IL-6 in bronchoalveolar lavage fluid (BALF). Furthermore, dexpanthenol attenuated MPO activity and MDA contents and increased SOD and GSH activity in the LPS-challenged lung tissue. These data suggest that dexpanthenol protects mice from LPS-induced acute lung injury by its anti-inflammatory and anti-oxidative activities.
authors.affiliation: Department of Respiratory Medicine, The First Affiliated Hospital of Guangdong Pharmaceutical University, Guangzhou, 510080, China.
authors.forename: Wan
authors.initials: W
authors.lastname: Li-Mei
authors.affiliation: Department of Respiratory Medicine, The First Affiliated Hospital of Guangdong Pharmaceutical University, Guangzhou, 510080, China.
authors.forename: Tan
authors.initials: T
authors.lastname: Jie
authors.affiliation: School of Pharmaceutical Science, Southern Medical University, Guangzhou, 510515, China.
authors.forename: Wan
authors.initials: W
authors.lastname: Shan-He
authors.affiliation: Department of Pharmacy, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510120, China.
authors.forename: Meng
authors.initials: M
authors.lastname: Dong-Mei
authors.affiliation: Department of Pharmacy, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510120, China. ypj725@163.com.
authors.forename: Yu
authors.identifier: http://orcid.org/0000-0002-9968-3280
authors.initials: Y
authors.lastname: Peng-Jiu
mesh_terms: D055371:Acute Lung Injury / Q000188:drug therapy* / Q000473:pathology; D000818:Animals; D000893:Anti-Inflammatory Agents; D000975:Antioxidants; D001992:Bronchoalveolar Lavage Fluid / Q000737:chemistry / Q000166:cytology; D016207:Cytokines / Q000378:metabolism; D007249:Inflammation / Q000188:drug therapy; D008070:Lipopolysaccharides; D051379:Mice; D020556:Neutrophil Infiltration / Q000187:drug effects; D010205:Pantothenic Acid / Q000031:analogs & derivatives* / Q000494:pharmacology; D011506:Proteins / Q000032:analysis / Q000378:metabolism
chemical_list: D000893:Anti-Inflammatory Agents; D000975:Antioxidants; D016207:Cytokines; D008070:Lipopolysaccharides; D011506:Proteins; D010205:Pantothenic Acid; C007288:dexpanthenol
keywords: acute lung injury; dexpanthenol; lipopolysaccharide