title: Effect of ionic interaction between a hyperpolarized magnetic resonance chemical probe and a gadolinium contrast agent for the hyperpolarized lifetime after dissolution.
abstract: In hyperpolarization of (13)C-enriched magnetic resonance chemical probes in the solid-state, a trace amount of gadolinium (Gd) contrast agent can be used to maximize polarization of the (13)C nuclear spins. Here, we report systematic measurement of the spin-lattice relaxation time (T1) and enhancement level of (13)C-enriched chemical probes in the presence of various Gd contrast agents in the liquid-state after dissolution. Using two different (13)C probes having opposite electric charges at neutral pH, we clearly show the T1 of hyperpolarized (13)C was barely affected by the use of a Gd complex that displays repulsive interaction with the (13)C probe in solution, whilst T1 was drastically shortened when there was ionic attraction between probe and complex.
authors.affiliation: Incubation Center for Advanced Medical Science, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan. Electronic address: tkksg@fmu.ac.jp.
authors.forename: Yoichi
authors.initials: Y
authors.lastname: Takakusagi
authors.affiliation: Incubation Center for Advanced Medical Science, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan.
authors.forename: Kaori
authors.initials: K
authors.lastname: Inoue
authors.affiliation: Japan Redox Ltd., 4-29-49-805 Chiyo, Hakata-ku, Fukuoka 812-0044, Japan.
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Naganuma
authors.affiliation: Innovation Center for Medical Redox Navigation, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan.
authors.forename: Fuminori
authors.initials: F
authors.lastname: Hyodo
authors.affiliation: Incubation Center for Advanced Medical Science, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan; Innovation Center for Medical Redox Navigation, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan. Electronic address: ichikawa.kazuhiro.684@m.kyushu-u.ac.jp.
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Ichikawa
keywords: Chemical probe; Gadolinium; Hyperpolarization; NMR; Spin-lattice relaxation time