title: Antimicrobial Agent Dosing in Infants.
abstract: The goal of this article was to review infant physiology and its effects on the pharmacokinetic properties of antimicrobial agents.
  
  
  
  A review of the drug development process was performed. A literature search was conducted on the pharmacokinetics of various antimicrobial agents in infants.
  
  
  
  The pharmacokinetic properties of antimicrobial agents in infants are most often affected by the renal maturation of premature infants. Hepatic metabolism and volume of distribution play a common role as well.
  
  
  
  The dosing and dosing intervals of various medications were reviewed and compared with details of adult dosing. It is vital to continue to gather pharmacokinetic data in infants to ensure adequate safety and dosing of medications.
authors.affiliation: Department of Pediatrics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina. Electronic address: jacob.johnson@unchealth.unc.edu.
authors.forename: Jacob K
authors.initials: JK
authors.lastname: Johnson
authors.affiliation: Department of Pediatrics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
authors.forename: Matthew M
authors.initials: MM
authors.lastname: Laughon
mesh_terms: D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000493:pharmacokinetics; D000890:Anti-Infective Agents / Q000008:administration & dosage* / Q000493:pharmacokinetics; D000935:Antifungal Agents / Q000008:administration & dosage / Q000493:pharmacokinetics; D000998:Antiviral Agents / Q000008:administration & dosage / Q000493:pharmacokinetics; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D055808:Drug Discovery / Q000379:methods; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007234:Infant, Premature / Q000378:metabolism; D007668:Kidney / Q000378:metabolism; D008099:Liver / Q000378:metabolism
chemical_list: D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D000935:Antifungal Agents; D000998:Antiviral Agents
keywords: Antibiotics; antifungals; antivirals; infants; pharmacokinetics