title: Prosthetic replacement vs space closure for maxillary lateral incisor agenesis: A systematic review.
abstract: BACKGROUND
  Defining the best treatment for maxillary lateral incisor agenesis is a challenge. Our aim in this study was to determine, with the evidence available in the literature, the best treatment for maxillary lateral incisor agenesis in the permanent dentition, evaluating the esthetic, occlusal (functional), and periodontal results between prosthetic replacement and orthodontic space closure.
  
  
  METHODS
  Electronic databases (CENTRAL, PubMed, Web of Science, Scopus, and LILACS) were searched in September 2014 and updated in January 2015, with no restriction on language or initial date. A manual search of the reference lists of the potential studies was performed. Risk of bias was assessed by the Newcastle Ottawa Scale.
  
  
  RESULTS
  The search identified 2174 articles, of which 1196 were excluded because they were duplicates. Titles and abstracts of 978 articles were accessed, and 957 were excluded. In total, 21 articles were read in full, and 9 case-control studies were included after applying the inclusion and exclusion criteria. Data were extracted from the articles selected, and a table was compiled for comparison and analysis of the results. There were no randomization and blinding, and the risk of bias evaluation found gaps in compatibility and outcome domains in almost all selected studies.
  
  
  CONCLUSIONS
  Tooth-supported dental prostheses of maxillary lateral incisor agenesis had worse scores in the periodontal indexes than did orthodontic space closure. Space closure is evaluated better esthetically than prosthetic replacements, and the presence or absence of a Class I relationship of the canines showed no relationship with occlusal function or with signs and symptoms of temporomandibular disorders.
authors.affiliation: Postgraduate student, Department of Orthodontics, Universidade Federal Fluminense, Niteroi, Rio de Janeiro, Brazil. Electronic address: giordanisilveira@hotmail.com.
authors.forename: Giordani Santos
authors.initials: GS
authors.lastname: Silveira
authors.affiliation: Postgraduate student, Department of Orthodontics, Universidade Federal Fluminense, Niteroi, Rio de Janeiro, Brazil.
authors.forename: Natália Valli
authors.initials: NV
authors.lastname: de Almeida
authors.affiliation: Librarian and postgraduate student, Health Science Center Library of the Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
authors.forename: Daniele Masterson Tavares
authors.initials: DM
authors.lastname: Pereira
authors.affiliation: Adjunct professor, Department of Orthodontics, Universidade Federal Fluminense, Niteroi, Rio de Janeiro, Brazil.
authors.forename: Cláudia Trindade
authors.initials: CT
authors.lastname: Mattos
authors.affiliation: Professor and chair, Department of Orthodontics, Universidade Federal Fluminense, Niteroi, Rio de Janeiro, Brazil.
authors.forename: José Nelson
authors.initials: JN
authors.lastname: Mucha
mesh_terms: D000848:Anodontia / Q000628:therapy*; D003481:Cuspid; D017266:Dental Prosthesis; D004955:Esthetics, Dental; D006801:Humans; D007180:Incisor / Q000002:abnormalities*; D008437:Maxilla; D019516:Orthodontic Space Closure / Q000379:methods*; D010512:Periodontal Index