title: miR-646 is a key negative regulator of EGFR pathway in lung cancer.
abstract: As one of the leading cause of cancer-related deaths in the worldwide, lung cancer needs to be understood better. Nowadays, increasing point mutations of specific oncogenes are biomarkers used to predict the therapeutic effect of targeted therapy and lung cancer has entered the age of individual treatment. At present, many relevant researchers have suggested that EGFR is a biomarker used to predict the therapeutic effect of targeted therapy. A large number of evidence indicates that EGFR/Akt pathway plays important role in cancer growth and metastasis.
  
  
  
  In this paper, we found EGFR was a target of miR-646.
  
  
  
  Overexpression of miR-646 not only downregulated EGFR/Akt pathway, but also inhibited lung cancer cell proliferation and metastasis. At the same time, miR-646 was a prognosis factor for overall survival.
  
  
  
  Our finding could provide new insights into the molecular therapeutic of lung cancer.
authors.affiliation: a Department of Respiratory and Critical Care Medicine, Changhai Hospital , Second Military Medical University , Yangpu District , Shanghai , China.|b Department of Respiratory Medicine , No. 92 Hospital of Chinese People's Liberation Army , Yanping District, Nanping , Fujian , China.
authors.forename: Yunhu
authors.initials: Y
authors.lastname: Pan
authors.affiliation: b Department of Respiratory Medicine , No. 92 Hospital of Chinese People's Liberation Army , Yanping District, Nanping , Fujian , China.
authors.forename: Yitan
authors.initials: Y
authors.lastname: Chen
authors.affiliation: c Department of Respiratory Medicine , General Hospital of Shenyang Military Area Command , Shenhe District, Shenyang , Liaoning , China.
authors.forename: Debin
authors.initials: D
authors.lastname: Ma
authors.affiliation: b Department of Respiratory Medicine , No. 92 Hospital of Chinese People's Liberation Army , Yanping District, Nanping , Fujian , China.
authors.forename: Zhiyu
authors.initials: Z
authors.lastname: Ji
authors.affiliation: b Department of Respiratory Medicine , No. 92 Hospital of Chinese People's Liberation Army , Yanping District, Nanping , Fujian , China.
authors.forename: Fangyu
authors.initials: F
authors.lastname: Cao
authors.affiliation: b Department of Respiratory Medicine , No. 92 Hospital of Chinese People's Liberation Army , Yanping District, Nanping , Fujian , China.
authors.forename: Zhibin
authors.initials: Z
authors.lastname: Chen
authors.affiliation: a Department of Respiratory and Critical Care Medicine, Changhai Hospital , Second Military Medical University , Yangpu District , Shanghai , China.
authors.forename: Yunye
authors.initials: Y
authors.lastname: Ning
authors.affiliation: a Department of Respiratory and Critical Care Medicine, Changhai Hospital , Second Military Medical University , Yangpu District , Shanghai , China.
authors.forename: Chong
authors.initials: C
authors.lastname: Bai
mesh_terms: D000072283:A549 Cells; D000328:Adult; D000368:Aged; D000818:Animals; D000070416:Antagomirs / Q000494:pharmacology / Q000627:therapeutic use*; D004353:Drug Evaluation, Preclinical; D066246:ErbB Receptors / Q000378:metabolism*; D006801:Humans; D008175:Lung Neoplasms / Q000378:metabolism*; D008297:Male; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D035683:MicroRNAs / Q000037:antagonists & inhibitors / Q000378:metabolism*; D008875:Middle Aged; D058990:Molecular Targeted Therapy; D009368:Neoplasm Transplantation; D051057:Proto-Oncogene Proteins c-akt / Q000378:metabolism; D011897:Random Allocation
chemical_list: D000070416:Antagomirs; C000592812:MIRN646 microRNA, human; C000625497:MIRN646 microRNA, mouse; D035683:MicroRNAs; C512478:EGFR protein, human; D066246:ErbB Receptors; D051057:Proto-Oncogene Proteins c-akt
keywords: EGFR; lung cancer; metastasis; prognosis; proliferation