title: Decellularized scaffolds in regenerative medicine.
abstract: Allogeneic organ transplantation remains the ultimate solution for end-stage organ failure. Yet, the clinical application is limited by the shortage of donor organs and the need for lifelong immunosuppression, highlighting the importance of developing effective therapeutic strategies. In the field of regenerative medicine, various regenerative technologies have lately been developed using various biomaterials to address these limitations. Decellularized scaffolds, derived mainly from various non-autologous organs, have been proved a regenerative capability in vivo and in vitro and become an emerging treatment approach. However, this regenerative capability varies between scaffolds as a result of the diversity of anatomical structure and cellular composition of organs used for decellularization. Herein, recent advances in scaffolds based on organ regeneration in vivo and in vitro are highlighted along with aspects where further investigations and analyses are needed.
authors.affiliation: Department of Anatomy, Wenzhou Medical University, Wenzhou, China.|Institute of Bioscaffold Transplantation and Immunology, Wenzhou Medical University, Wenzhou, China.
authors.forename: Yaling
authors.initials: Y
authors.lastname: Yu
authors.affiliation: Department of Anatomy, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia.
authors.forename: Ali
authors.initials: A
authors.lastname: Alkhawaji
authors.affiliation: Institute of Neuroscience, Wenzhou Medical University, Wenzhou, China.
authors.forename: Yuqiang
authors.initials: Y
authors.lastname: Ding
authors.affiliation: Department of Anatomy, Wenzhou Medical University, Wenzhou, China.|Institute of Bioscaffold Transplantation and Immunology, Wenzhou Medical University, Wenzhou, China.|Institute of Neuroscience, Wenzhou Medical University, Wenzhou, China.
authors.forename: Jin
authors.initials: J
authors.lastname: Mei
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry*; D001921:Brain / Q000502:physiology; D006321:Heart / Q000502:physiology; D006801:Humans; D007668:Kidney / Q000502:physiology; D008099:Liver / Q000502:physiology; D008168:Lung / Q000502:physiology; D010179:Pancreas / Q000502:physiology; D012038:Regeneration; D044968:Regenerative Medicine / Q000379:methods*; D012879:Skin Physiological Phenomena; D013116:Spinal Cord / Q000502:physiology; D023822:Tissue Engineering / Q000379:methods*; D054457:Tissue Scaffolds / Q000737:chemistry*
chemical_list: D001672:Biocompatible Materials
keywords: decellularized scaffold; extracellular matrix; in vivo/in vitro; organ; regeneration