title: Antioxidant status of serum bilirubin and uric acid in patients with polymyositis and dermatomyositis.
abstract: OBJECTIVE
  Oxidative stress and variations in antioxidant status are implicated in the pathogenesis of inflammatory and autoimmune diseases. Polymyositis and dermatomyositis (PM/DM) are autoimmune diseases with inflammatory cells infiltrating into skeletal muscles, and the antioxidant status is still controversial. The aim of our study was to investigate the correlation between PM/DM and the antioxidant status of serum bilirubin (Tbil, Dbil and Ibil) and uric acid (UA).
  
  
  METHODS
  We measured serum concentrations of bilirubin (Tbil, Dbil and Ibil) and uric acid in 384 individuals, including 110 PM/DM patients and 274 healthy controls.
  
  
  RESULTS
  We found that PM/DM patients had significantly lower serum concentrations of bilirubin (Tbil and Ibil) and uric acid than healthy controls, whether male or female. Also, after separately adjusting the covariances of age and gender, Tbil, Dbil, Ibil and UA were all relevant factors for PM/DM. Moreover, there were no significant differences in serum antioxidant molecule levels between PM and DM subgroups.
  
  
  CONCLUSIONS
  Our study demonstrated the low serum levels of bilirubin and uric acid in patients with PM/DM. This suggested low antioxidant status in PM/DM patients with excessive oxidative stress.
authors.affiliation: a Department of Neurology, The First Affiliated Hospital of Wenzhou Medical University , Wenzhou , China.
authors.forename: Zhibo
authors.initials: Z
authors.lastname: Chen
authors.affiliation: a Department of Neurology, The First Affiliated Hospital of Wenzhou Medical University , Wenzhou , China.
authors.forename: Zhongqian
authors.initials: Z
authors.lastname: Su
authors.affiliation: a Department of Neurology, The First Affiliated Hospital of Wenzhou Medical University , Wenzhou , China.
authors.forename: Wanhui
authors.initials: W
authors.lastname: Pang
authors.affiliation: a Department of Neurology, The First Affiliated Hospital of Wenzhou Medical University , Wenzhou , China.
authors.forename: Yuanyuan
authors.initials: Y
authors.lastname: Huang
authors.affiliation: a Department of Neurology, The First Affiliated Hospital of Wenzhou Medical University , Wenzhou , China.
authors.forename: Jie
authors.initials: J
authors.lastname: Lin
authors.affiliation: b Department of Intensive Care Unit, Ruian People's Hospital, The Third Affiliated Hospital of Wenzhou Medical University , Wenzhou , China.
authors.forename: Zhangna
authors.initials: Z
authors.lastname: Ding
authors.affiliation: c Department of Endocrinology, The First Affiliated Hospital of Wenzhou Medical University , Wenzhou , China.
authors.forename: Senmin
authors.initials: S
authors.lastname: Wu
authors.affiliation: d Department of Intensive Care Unit, The First Affiliated Hospital of Wenzhou Medical University , Wenzhou , China.
authors.forename: Shunyao
authors.initials: S
authors.lastname: Xu
authors.affiliation: a Department of Neurology, The First Affiliated Hospital of Wenzhou Medical University , Wenzhou , China.
authors.forename: Weiwei
authors.initials: W
authors.lastname: Quan
authors.affiliation: e Department of Gastroenterology, The First Affiliated Hospital of Wenzhou Medical University , Wenzhou , China.
authors.forename: Juzeng
authors.initials: J
authors.lastname: Zheng
authors.affiliation: f Department of Laboratory Medicine, The First Affiliated Hospital of Wenzhou Medical University , Wenzhou , China.
authors.forename: Huale
authors.initials: H
authors.lastname: Chen
authors.affiliation: a Department of Neurology, The First Affiliated Hospital of Wenzhou Medical University , Wenzhou , China.
authors.forename: Zhengzheng
authors.initials: Z
authors.lastname: Li
authors.affiliation: a Department of Neurology, The First Affiliated Hospital of Wenzhou Medical University , Wenzhou , China.
authors.forename: Xiang
authors.initials: X
authors.lastname: Li
authors.affiliation: a Department of Neurology, The First Affiliated Hospital of Wenzhou Medical University , Wenzhou , China.
authors.forename: Jia
authors.initials: J
authors.lastname: Li
authors.affiliation: a Department of Neurology, The First Affiliated Hospital of Wenzhou Medical University , Wenzhou , China.
authors.forename: Yiyun
authors.initials: Y
authors.lastname: Weng
authors.affiliation: a Department of Neurology, The First Affiliated Hospital of Wenzhou Medical University , Wenzhou , China.
authors.forename: Xu
authors.initials: X
authors.lastname: Zhang
mesh_terms: D000328:Adult; D000368:Aged; D001663:Bilirubin / Q000097:blood*; D003882:Dermatomyositis / Q000097:blood; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress / Q000502:physiology*; D017285:Polymyositis / Q000097:blood*; D014527:Uric Acid / Q000097:blood*
chemical_list: D014527:Uric Acid; D001663:Bilirubin
keywords: antioxidant; bilirubin; dermatomyositis; polymyositis; uric acid