title: Orthobiologic Interventions Using Ultrasound Guidance.
abstract: The application of regenerative therapies for the treatment of musculoskeletal conditions has emerged over the last decade with recent acceleration. These include prolotherapy, platelet-rich plasma, and mesenchymal stem cell therapy. These strategies augment the body's innate physiology to heal pathologic processes. This article presents an overview of platelet-rich plasma and mesenchymal stem cell therapy for the treatment of musculoskeletal injuries. A brief literature review is included, as are techniques for the use of ultrasound guidance to assist with these procedures.
authors.affiliation: Department of Physical Medicine and Rehabilitation, Rutgers University-New Jersey Medical School, Newark, NJ, USA; New Jersey Regenerative Institute, 197 Ridgedale Avenue, Suite 210, Cedar Knolls, NJ 07927, USA. Electronic address: gmalangamd@hotmail.com.
authors.forename: Gerard
authors.initials: G
authors.lastname: Malanga
authors.affiliation: Department of Physical Medicine and Rehabilitation, Rutgers University-New Jersey Medical School, Newark, NJ, USA.
authors.forename: Dena
authors.initials: D
authors.lastname: Abdelshahed
authors.affiliation: Department of Physical Medicine and Rehabilitation, Baylor College of Medicine, Houston, TX, USA.
authors.forename: Prathap
authors.initials: P
authors.lastname: Jayaram
mesh_terms: D000273:Adipose Tissue / Q000637:transplantation; D002908:Chronic Disease; D005271:Femur Head Necrosis / Q000628:therapy; D006801:Humans; D045164:Mesenchymal Stem Cell Transplantation / Q000009:adverse effects / Q000379:methods*; D009140:Musculoskeletal Diseases / Q000000981:diagnostic imaging / Q000628:therapy*; D010003:Osteoarthritis / Q000628:therapy; D053657:Platelet-Rich Plasma; D052256:Tendinopathy / Q000628:therapy; D013716:Tennis Elbow / Q000628:therapy; D018084:Ultrasonography, Interventional / Q000379:methods*; D014947:Wounds and Injuries / Q000000981:diagnostic imaging / Q000628:therapy*
keywords: Biologic agents; Ligament; Muscle; Orthobiologics; Platelet-rich plasma; Regenerative medicine; Stem cell therapy; Tendon