title: EVALUATION OF THE SYNTHESIS AND STRUCTURE OF NEW AZETIDIN-2-ONES OF FERULIC ACID.
abstract: OBJECTIVE
  To synthesize some new azetidin-2-ones of ferulic acid and to evaluate them from physicochemical and spectral point of view.
  
  
  METHODS
  The synthesis was carried out in several steps: (i) obtaining the ferulic acid chloride; (ii) obtaining the ferulic acid hydrazide with hydrazine hydrate (98%); (iii) condensation of ferulic acid hydrazide with different benzaldehydes (2-hydroxy-/2-nitro-/4-chloro-/4- fluoro-/4-bromo-benzaldehyde) in order to obtain the corresponding hydrazones; (iv) cy- clization of ferulic acid hydrazones with chloroacethyl chloride in freshly distilled toluene medium and in the presence of triethylamine, resulting in the corresponding azetidin-2-ones.
  
  
  RESULTS
  Six new azetidin-2-ones of ferulic acid were synthesized. They were characterized in terms of their physicochemical properties and their structure was confirmed by IR and 1H-NMR spectroscopy.
  
  
  CONCLUSIONS
  Six new azetidin-2-ones of ferulic acid were synthesized, physicochemically characterized and validated spectrally. A
authors.forename: Cătălina Daniela
authors.initials: CD
authors.lastname: Stan
authors.forename: Maria
authors.initials: M
authors.lastname: Drăgan
authors.forename: Andreea
authors.initials: A
authors.lastname: Pânzariu
authors.forename: Lenuţa
authors.initials: L
authors.lastname: Profire
mesh_terms: D000975:Antioxidants / Q000138:chemical synthesis*; D001384:Azetidines / Q000138:chemical synthesis*; D001547:Benzaldehydes / Q000737:chemistry; D002273:Carcinogens / Q000737:chemistry*; D002712:Chlorides / Q000737:chemistry*; D003373:Coumaric Acids / Q000737:chemistry*; D005021:Ethylamines / Q000737:chemistry; D006834:Hydrazines / Q000737:chemistry*; D006835:Hydrazones / Q000737:chemistry; D007202:Indicators and Reagents / Q000737:chemistry*; D012997:Solvents / Q000737:chemistry; D013055:Spectrophotometry, Infrared / Q000379:methods; D017550:Spectroscopy, Fourier Transform Infrared / Q000379:methods; D014050:Toluene / Q000737:chemistry
chemical_list: D000975:Antioxidants; D001384:Azetidines; D001547:Benzaldehydes; D002273:Carcinogens; D002712:Chlorides; D003373:Coumaric Acids; D005021:Ethylamines; D006834:Hydrazines; D006835:Hydrazones; D007202:Indicators and Reagents; D012997:Solvents; C029424:hydrazine; D014050:Toluene; C004999:ferulic acid; C016162:triethylamine