title: Dietary Nanosized Lactobacillus plantarum Enhances the Anticancer Effect of Kimchi on Azoxymethane and Dextran Sulfate Sodium-Induced Colon Cancer in C57BL/6J Mice.
abstract: This study was undertaken to evaluate enhancement of the chemopreventive properties of kimchi by dietary nanosized Lactobacillus (Lab.)plantarum (nLp) in an azoxymethane (AOM)/dextran sulfate sodium (DSS)-induced colitis-associated colorectal cancer C57BL/6J mouse model. nLp is a dead, shrunken, processed form of Lab. Plantarum isolated from kimchi that is 0.5-1.0 µm in size. The results obtained showed that animals fed kimchi with nLp (K-nLp) had longer colons and lower colon weights/length ratios and developed fewer tumors than mice fed kimchi alone (K). In addition, K-nLp administration reduced levels of proinflammatory cytokine serum levels and mediated the mRNA and protein expressions of inflammatory, apoptotic, and cell-cycle markers to suppress inflammation and induce tumor-cell apoptosis and cell-cycle arrest. Moreover, it elevated natural killer-cell cytotoxicity. The study suggests adding nLp to kimchi could improve the suppressive effect of kimchi on AOM/DSS-induced colorectal cancer. These findings indicate nLp has potential use as a functional chemopreventive ingredient in the food industry.
authors.affiliation: Department of Biotechnology, College of Life Science and Biotechnology, Korea University, Seoul 02856, Republic of Korea.
authors.forename: Hyun Ah
authors.initials: HA
authors.lastname: Lee
authors.affiliation: Biogenics Korea Co., Seoul 06628, Republic of Korea.
authors.forename: Hyunung
authors.initials: H
authors.lastname: Kim
authors.affiliation: Department of Biotechnology, College of Life Science and Biotechnology, Korea University, Seoul 02856, Republic of Korea.
authors.forename: Kwang-Won
authors.initials: KW
authors.lastname: Lee
authors.affiliation: 3Chongqing Collaborative Innovation Center for Functional Food, Chongqing University of Education, Chongqing 400067, People's Republic of China; Department of Food Science and Biotechnology, Cha University, Gyeonggido 13488, Republic of Korea.
authors.forename: Kun-Young
authors.initials: KY
authors.lastname: Park
mesh_terms: D000818:Animals; D001397:Azoxymethane / Q000494:pharmacology; D002273:Carcinogens / Q000494:pharmacology; D003092:Colitis / Q000139:chemically induced / Q000473:pathology / Q000517:prevention & control*; D003106:Colon / Q000737:chemistry / Q000502:physiology; D016264:Dextran Sulfate / Q000494:pharmacology; D004032:Diet; D005285:Fermentation; D055951:Functional Food / Q000032:analysis* / Q000382:microbiology; D048191:Lactiplantibacillus plantarum / Q000502:physiology*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D019936:Probiotics / Q000008:administration & dosage*
chemical_list: D002273:Carcinogens; D016264:Dextran Sulfate; D001397:Azoxymethane