title: Blood vessel formation and function in bone.
abstract: In addition to their conventional role as a conduit system for gases, nutrients, waste products or cells, blood vessels in the skeletal system play active roles in controlling multiple aspects of bone formation and provide niches for hematopoietic stem cells that reside within the bone marrow. In addition, recent studies have highlighted roles for blood vessels during bone healing. Here, we provide an overview of the architecture of the bone vasculature and discuss how blood vessels form within bone, how their formation is modulated, and how they function during development and fracture repair.
authors.affiliation: Max-Planck-Institute for Molecular Biomedicine, Department of Tissue Morphogenesis and University of Münster, Faculty of Medicine, Münster D-48149, Germany.
authors.forename: Kishor K
authors.initials: KK
authors.lastname: Sivaraj
authors.affiliation: Max-Planck-Institute for Molecular Biomedicine, Department of Tissue Morphogenesis and University of Münster, Faculty of Medicine, Münster D-48149, Germany ralf.adams@mpi-muenster.mpg.de.
authors.forename: Ralf H
authors.identifier: 0000-0003-3031-7677
authors.initials: RH
authors.lastname: Adams
mesh_terms: D000818:Animals; D001842:Bone and Bones / Q000098:blood supply*; D019902:Chondrocytes / Q000166:cytology; D042783:Endothelial Cells / Q000166:cytology; D006801:Humans; D018919:Neovascularization, Physiologic / Q000502:physiology; D010006:Osteoblasts / Q000166:cytology; D010010:Osteoclasts / Q000166:cytology; D010012:Osteogenesis / Q000502:physiology*; D014945:Wound Healing / Q000502:physiology
keywords: Angiogenesis; Blood vessels; Bone; Chondrocyte; Endothelial cell; Osteoblast; Osteoclast