title: Impact of body mass index on outcome in stroke patients treated with intravenous thrombolysis.
abstract: The impact of body mass index (BMI) on outcome in stroke patients treated with intravenous thrombolysis (IVT) was investigated.
  
  
  
  In a multicentre IVT-register-based observational study, BMI with (i) poor 3-month outcome (i.e. modified Rankin Scale scores 3-6), (ii) death and (iii) symptomatic intracranial haemorrhage (sICH) based on criteria of the ECASS II trial was compared. BMI was used as a continuous and categorical variable distinguishing normal weight (reference group 18.5-24.9 kg/m2) from underweight (<18.5 kg/m2), overweight (25-29.9 kg/m2) and obese (≥30 kg/m2) patients. Univariable and multivariable regression analyses with adjustments for age and stroke severity were done and odds ratios with 95% confidence intervals [OR (95% CI)] were calculated.
  
  
  
  Of 1798 patients, 730 (40.6%) were normal weight, 55 (3.1%) were underweight, 717 (39.9%) overweight and 295 (16.4%) obese. Poor outcome occurred in 38.1% of normal weight patients and did not differ significantly from underweight (45.5%), overweight (36.1%) and obese (32.5%) patients. The same was true for death (9.5% vs. 14.5%, 9.6% and 7.5%) and sICH (3.9% vs. 5.5%, 4.3%, 2.7%). Neither in univariable nor in multivariable analyses did the risks of poor outcome, death or sICH differ significantly between BMI groups. BMI as a continuous variable was not associated with poor outcome, death or sICH in unadjusted [OR (95% CI) 0.99 (0.97-1.01), 0.98 (0.95-1.02), 0.98 (0.94-1.04)] or adjusted analyses [OR (95% CI) 1.01 (0.98-1.03), 0.99 (0.95-1.05), 1.01 (0.97-1.05)], respectively.
  
  
  
  In this largest study to date, investigating the impact of BMI in IVT-treated stroke patients, BMI had no prognostic meaning with regard to 3-month functional outcome, death or occurrence of sICH.
authors.affiliation: Stroke Centre and Neurology, University Hospital Basel, Basel, Switzerland.
authors.forename: H
authors.initials: H
authors.lastname: Gensicke
authors.affiliation: Stroke Centre and Neurology, University Hospital Basel, Basel, Switzerland.
authors.forename: A
authors.initials: A
authors.lastname: Wicht
authors.affiliation: Department of Neurology, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland.
authors.forename: O
authors.initials: O
authors.lastname: Bill
authors.affiliation: Stroke Unit, Department of Neuroscience, Nuovo Ospedale Civile S. Agostino-Estense, AUSL Modena, Modena, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Zini
authors.affiliation: Department of Clinical and Experimental Sciences, Neurology Clinic, University of Brescia, Brescia, Italy.
authors.forename: P
authors.initials: P
authors.lastname: Costa
authors.affiliation: Department of Neurology, Kantonsspital St Gallen, St Gallen, Switzerland.
authors.forename: G
authors.initials: G
authors.lastname: Kägi
authors.affiliation: Department of Neurology, Kantonsspital St Gallen, St Gallen, Switzerland.
authors.forename: R
authors.initials: R
authors.lastname: Stark
authors.affiliation: Stroke Centre and Neurology, University Hospital Basel, Basel, Switzerland.
authors.forename: D J
authors.initials: DJ
authors.lastname: Seiffge
authors.affiliation: Stroke Centre and Neurology, University Hospital Basel, Basel, Switzerland.
authors.forename: C
authors.initials: C
authors.lastname: Traenka
authors.affiliation: Stroke Centre and Neurology, University Hospital Basel, Basel, Switzerland.
authors.forename: N
authors.initials: N
authors.lastname: Peters
authors.affiliation: Stroke Centre and Neurology, University Hospital Basel, Basel, Switzerland.
authors.forename: L H
authors.initials: LH
authors.lastname: Bonati
authors.affiliation: Stroke Unit, Department of Neuroscience, Nuovo Ospedale Civile S. Agostino-Estense, AUSL Modena, Modena, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Giovannini
authors.affiliation: Stroke Centre and Neurology, University Hospital Basel, Basel, Switzerland.
authors.forename: G M
authors.initials: GM
authors.lastname: De Marchis
authors.affiliation: Department of Clinical and Experimental Sciences, Neurology Clinic, University of Brescia, Brescia, Italy.
authors.forename: L
authors.initials: L
authors.lastname: Poli
authors.affiliation: Stroke Centre and Neurology, University Hospital Basel, Basel, Switzerland.
authors.forename: A
authors.initials: A
authors.lastname: Polymeris
authors.affiliation: Department of Neurology, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland.|Department of Neurology, University Hospital Antwerp, Edegem, Belgium.
authors.forename: P
authors.initials: P
authors.lastname: Vanacker
authors.affiliation: Department of Neurology, University Hospital Berne, Berne, Switzerland.
authors.forename: H
authors.initials: H
authors.lastname: Sarikaya
authors.affiliation: Stroke Centre and Neurology, University Hospital Basel, Basel, Switzerland.
authors.forename: P A
authors.initials: PA
authors.lastname: Lyrer
authors.affiliation: Department of Clinical and Experimental Sciences, Neurology Clinic, University of Brescia, Brescia, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Pezzini
authors.affiliation: Stroke Unit, Department of Neuroscience, Nuovo Ospedale Civile S. Agostino-Estense, AUSL Modena, Modena, Italy.
authors.forename: L
authors.initials: L
authors.lastname: Vandelli
authors.affiliation: Department of Neurology, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland.
authors.forename: P
authors.initials: P
authors.lastname: Michel
authors.affiliation: Stroke Centre and Neurology, University Hospital Basel, Basel, Switzerland.|Neurorehabilitation Unit, University Centre for Medicine of Aging and Rehabilitation, Felix Platter Hospital, Basel, Switzerland.
authors.forename: S T
authors.initials: ST
authors.lastname: Engelter
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D015992:Body Mass Index; D002545:Brain Ischemia / Q000188:drug therapy*; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D020300:Intracranial Hemorrhages / Q000209:etiology; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012306:Risk; D020521:Stroke / Q000188:drug therapy*; D015912:Thrombolytic Therapy / Q000009:adverse effects*; D016896:Treatment Outcome
keywords: body mass index; intravenous thrombolysis; outcome; stroke; symptomatic intracranial haemorrhage