title: Copper-Promoted Cyclization of α-Amino Nitrile-Tethered Enynes: Controllable Synthesis of 3-Azabicyclo[4.1.0]hepta-2,4-dienes and 4,5-Dihydro-3H-azepines.
abstract: The first example of Cu-promoted cyclization of α-amino nitrile-tethered enynes incorporating an electron-deficient alkene component is described. A wide range of functionalized 3-azabicyclo[4.1.0]hepta-2,4-dienes and 4,5-dihydro-3H-azepines were prepared efficiently in a controllable manner. Moreover, the diverse cascade process enables efficient incorporation of tertiary amine moieties under mild reaction conditions. A possible reaction pathway is proposed on the basis of a series of control experiments.
authors.affiliation: College of Chemistry and ‡College of Life Science, Jilin University , 2699 Qianjin Street, Changchun 130012, China.
authors.forename: Qiu-Qin
authors.initials: QQ
authors.lastname: Xu
authors.affiliation: College of Chemistry and ‡College of Life Science, Jilin University , 2699 Qianjin Street, Changchun 130012, China.
authors.forename: Qi-Lan
authors.initials: QL
authors.lastname: Hou
authors.affiliation: College of Chemistry and ‡College of Life Science, Jilin University , 2699 Qianjin Street, Changchun 130012, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Liu
authors.affiliation: College of Chemistry and ‡College of Life Science, Jilin University , 2699 Qianjin Street, Changchun 130012, China.
authors.forename: Hai-Jing
authors.initials: HJ
authors.lastname: Wang
authors.affiliation: College of Chemistry and ‡College of Life Science, Jilin University , 2699 Qianjin Street, Changchun 130012, China.
authors.forename: Wei-Wei
authors.initials: WW
authors.lastname: Liao