title: Immune Response Signaling: Combinatorial and Dynamic Control.
abstract: Macrophages mount complex responses to pathogens. Although several key signaling pathways have been identified, it remains unclear how they work together to provide specificity. In a recent paper, Gottschalk et al. report that differential dose-response behaviors of the NFκB and MAPK pathways allow dose-specific gene expression programs.
authors.affiliation: Department of Microbiology, Immunology, and Molecular Genetics, Institute for Quantitative and Computational Biosciences, UCLA, Los Angeles, CA, USA. Electronic address: ahoffmann@ucla.edu.
authors.forename: Alexander
authors.initials: A
authors.lastname: Hoffmann
mesh_terms: D000818:Animals; D016207:Cytokines / Q000378:metabolism; D048049:Extracellular Signal-Regulated MAP Kinases / Q000378:metabolism; D053263:Gene Regulatory Networks; D006801:Humans; D007111:Immunity, Cellular; D007249:Inflammation / Q000276:immunology*; D008264:Macrophages / Q000276:immunology*; D016328:NF-kappa B / Q000378:metabolism; D020239:Receptor Cross-Talk; D051192:Receptors, Pattern Recognition / Q000378:metabolism; D015398:Signal Transduction; D015533:Transcriptional Activation
chemical_list: D016207:Cytokines; D016328:NF-kappa B; D051192:Receptors, Pattern Recognition; D048049:Extracellular Signal-Regulated MAP Kinases