title: Vitamin A-retinoid signaling in pulmonary development and disease.
abstract: Retinoic acid (RA), the active form of vitamin A, regulates key developmental processes in multiple organs. In the developing lung, RA is crucial for normal growth and differentiation of airways. Disruption in RA signaling or vitamin A deficiency (VAD) has been linked to aberrant development of the lung including alterations in the airway smooth muscle (SM) differentiation, development, and function. These alterations have been linked to disease states including asthma in both human and animal models.
authors.affiliation: Pulmonary Center, Boston University School of Medicine, Boston, MA, 02118, USA. hemarque@bu.edu.
authors.forename: Hector A
authors.initials: HA
authors.lastname: Marquez
authors.affiliation: Department of Medicine, Columbia Center for Human Development, Columbia University Medical Center, New York, NY, 10032, USA. wvc2104@cumc.columbia.edu.
authors.forename: Wellington V
authors.initials: WV
authors.lastname: Cardoso
keywords: Airway hyperresponsiveness; Asthma; Developmental pathways; Lung development; Retinoic acid; Smooth muscle; Vitamin A