title: Synthetic Approaches to Trifluoromethoxy-Substituted Compounds.
abstract: Because of the unique properties of the trifluoromethoxy group, molecules bearing this moiety will find applications in various fields, particularly in the life sciences. However, despite the great interest in this functional group, only a small number of trifluoromethoxylated molecules are currently synthetically accessible. Over the last few years, several innovative and promising strategies for the synthesis of trifluoromethoxylated compounds have been described. This Minireview discusses these existing methods with a particular focus on more recent advances.
authors.affiliation: Institute of Chemistry and Biochemistry (ICBMS-UMR CNRS 5246), Univ Lyon, Université Lyon 1, CNRS, 43 Bd du 11 Novembre 1918, F-69622, Villeurbanne, France. anis.tlili@univ-lyon1.fr.
authors.forename: Anis
authors.identifier: 0000-0002-3058-2043
authors.initials: A
authors.lastname: Tlili
authors.affiliation: Institute of Chemistry and Biochemistry (ICBMS-UMR CNRS 5246), Univ Lyon, Université Lyon 1, CNRS, 43 Bd du 11 Novembre 1918, F-69622, Villeurbanne, France. fabien.toulgoat@cpe.fr.|CPE-Lyon, Campus LyonTech-la Doua, 43 Bd du 11 Novembre 1918, F-69616, Villeurbanne, France. fabien.toulgoat@cpe.fr.
authors.forename: Fabien
authors.identifier: 0000-0001-7339-4985
authors.initials: F
authors.lastname: Toulgoat
authors.affiliation: Institute of Chemistry and Biochemistry (ICBMS-UMR CNRS 5246), Univ Lyon, Université Lyon 1, CNRS, 43 Bd du 11 Novembre 1918, F-69622, Villeurbanne, France. thierry.billard@univ-lyon1.fr.|CERMEP-in vivo imaging, Groupement Hospitalier Est, 59 Bd Pinel, F-69003, Lyon, France. thierry.billard@univ-lyon1.fr.
authors.forename: Thierry
authors.identifier: 0000-0002-2937-9523
authors.initials: T
authors.lastname: Billard
keywords: fluorine; hypervalent iodine compounds; synthetic methods; trifluoromethoxide; trifluoromethoxylation