title: Biodegradable polymeric microcapsules for sustained release of riboflavin.
abstract: In the current study, a series of polylactic acid and polylactic-co-glycolic acid were prepared in an easy, simple, safe and economically feasible way with yield% greater than 90%. Studying the effect of a catalyst on polymerization process was performed. Riboflavin (RF) was chosen as a model drug and microencapsulated in different (drug: polymer) ratios to modify its performance via o/w emulsion solvent evaporation technique and characterized in terms of the morphology and entrapment efficiency (E.E.) and evaluated via in vitro RF release studies. It has been found that, the release rate consists a burst release at the first 12h, followed by a gradual release over 3days. The cumulative riboflavin release from these microcapsules formulations at the end of 3days was 70% and 80% for PDLA and PDLAGA respectively. The kinetics of release profiles were zero order. The highest (E.E.) of RF obtained among all formulations was 85%.
authors.affiliation: Chemistry Department, Faculty of Science, Al-Azhar University, Nasr City, Cairo, Egypt; Solid dosage forms Department, EIPICO, Egypt.
authors.forename: A M
authors.initials: AM
authors.lastname: Abd El-Hay
authors.affiliation: Chemistry Department, Faculty of Science, Al-Azhar University, Nasr City, Cairo, Egypt.
authors.forename: A M
authors.initials: AM
authors.lastname: Naser
authors.affiliation: Pharmaceutics and Industrial Pharmacy Department, Faculty of Pharmacy, Cairo University, Cairo, Egypt.
authors.forename: A
authors.initials: A
authors.lastname: Badawi
authors.affiliation: Polymers and Pigments Department, National Research Center, Dokki, Giza, Egypt.
authors.forename: M A
authors.initials: MA
authors.lastname: Abd El-Ghaffar
authors.affiliation: Chemistry Department, Faculty of Science, Al-Azhar University, Nasr City, Cairo, Egypt. Electronic address: hamada199820000@yahoo.com.
authors.forename: H
authors.initials: H
authors.lastname: Abd El-Wahab
authors.affiliation: Pharmaceutics and Industrial Pharmacy Department, Faculty of Pharmacy, Modern University for Technology and Information (MTI), Cairo, Egypt.
authors.forename: Doaa A
authors.initials: DA
authors.lastname: Helal
mesh_terms: D002214:Capsules; D003692:Delayed-Action Preparations; D004339:Drug Compounding / Q000379:methods; D065546:Drug Liberation; D004655:Emulsions; D007700:Kinetics; D019344:Lactic Acid / Q000737:chemistry*; D010316:Particle Size; D017319:Photosensitizing Agents / Q000737:chemistry*; D011091:Polyesters / Q000737:chemistry*; D011100:Polyglycolic Acid / Q000737:chemistry*; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D012256:Riboflavin / Q000737:chemistry*; D012996:Solutions
chemical_list: D002214:Capsules; D003692:Delayed-Action Preparations; D004655:Emulsions; D017319:Photosensitizing Agents; D011091:Polyesters; D012996:Solutions; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D019344:Lactic Acid; C033616:poly(lactide); D012256:Riboflavin
keywords: Biocompatible; Biodegradable; Microcapsules; Riboflavin