title: Bone marrow mesenchymal stem cell therapy in ischemic stroke: mechanisms of action and treatment optimization strategies.
abstract: Animal and clinical studies have confirmed the therapeutic effect of bone marrow mesenchymal stem cells on cerebral ischemia, but their mechanisms of action remain poorly understood. Here, we summarize the transplantation approaches, directional migration, differentiation, replacement, neural circuit reconstruction, angiogenesis, neurotrophic factor secretion, apoptosis, immunomodulation, multiple mechanisms of action, and optimization strategies for bone marrow mesenchymal stem cells in the treatment of ischemic stroke. We also explore the safety of bone marrow mesenchymal stem cell transplantation and conclude that bone marrow mesenchymal stem cell transplantation is an important direction for future treatment of cerebral ischemia. Determining the optimal timing and dose for the transplantation are important directions for future research.
authors.affiliation: Department of Neurosurgery, the First Hospital of Jilin University, Changchun, Jilin Province, China; Department of Neurosurgery, Hongqi Hospital of Mudanjiang Medical University, Mudanjiang, Heilongjiang Province, China.
authors.forename: Guihong
authors.initials: G
authors.lastname: Li
authors.affiliation: School of Pharmacy, Mudanjiang Medical University, Mudanjiang, Heilongjiang Province, China.
authors.forename: Fengbo
authors.initials: F
authors.lastname: Yu
authors.affiliation: Department of Neurosurgery, the First Hospital of Jilin University, Changchun, Jilin Province, China.
authors.forename: Ting
authors.initials: T
authors.lastname: Lei
authors.affiliation: Department of Neurosurgery, the First Hospital of Jilin University, Changchun, Jilin Province, China.
authors.forename: Haijun
authors.initials: H
authors.lastname: Gao
authors.affiliation: Department of Neurosurgery, the First Hospital of Jilin University, Changchun, Jilin Province, China.
authors.forename: Peiwen
authors.initials: P
authors.lastname: Li
authors.affiliation: Department of Neurosurgery, the First Hospital of Jilin University, Changchun, Jilin Province, China.
authors.forename: Yuxue
authors.initials: Y
authors.lastname: Sun
authors.affiliation: Department of Neurosurgery, the First Hospital of Jilin University, Changchun, Jilin Province, China.
authors.forename: Haiyan
authors.initials: H
authors.lastname: Huang
authors.affiliation: Department of Neurosurgery, Hongqi Hospital of Mudanjiang Medical University, Mudanjiang, Heilongjiang Province, China.
authors.forename: Qingchun
authors.identifier: 0000-0003-1082-2692
authors.initials: Q
authors.lastname: Mu
keywords: angiogenesis; animal model; clinical application; genetic modification; ischemia/reperfusion injury; mechanisms of action; nerve regeneration; neural regeneration; replacement therapy; research progress