title: Fabrication of a novel bone ash-reinforced gelatin/alginate/hyaluronic acid composite film for controlled drug delivery.
abstract: In this study, a novel pH-sensitive composite film with enhanced thermal and mechanical properties was prepared by the incorporation of bone ash at varying concentrations from 0 to 10v.% into gelatin/sodium alginate/hyaluronic acid (Gel/SA/HyA) polymeric structure for colon-specific drug delivery system. Films were characterized by FT-IR, SEM, and XRD analyses. Thermal and mechanical performances of films were determined by DSC, TGA and universal mechanical tester, respectively. Results proved that thermal stability and mechanical properties of bone ash-reinforced composite films improved significantly with respect to that of neat Gel/SA/HyA film. Cytotoxicity assay for composite films was carried out by using L929 cells. Water uptake capacity of films was determined by swelling test. Herein, release experiments of 5-Fluorouracil (5-FU) were performed in two different solutions (pH 2.1 and 7.4). The results assured that Gel/SA/HyA film containing BA could be considered as a potential biomaterial for controlled drug delivery systems.
authors.affiliation: Marmara University, Department of Chemical Engineering, 34722 Istanbul, Turkey. Electronic address: neslihan.alemdar@marmara.edu.tr.
authors.forename: Neslihan
authors.initials: N
authors.lastname: Alemdar
mesh_terms: D000464:Alginates / Q000737:chemistry*; D000818:Animals; D002460:Cell Line; D003106:Colon / Q000378:metabolism; D003692:Delayed-Action Preparations; D004337:Drug Carriers / Q000737:chemistry* / Q000633:toxicity; D065546:Drug Liberation; D005780:Gelatin / Q000737:chemistry*; D020723:Glucuronic Acid / Q000737:chemistry; D006603:Hexuronic Acids / Q000737:chemistry; D006820:Hyaluronic Acid / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D051379:Mice; D008903:Minerals / Q000737:chemistry*; D009928:Organ Specificity; D013696:Temperature; D014867:Water / Q000737:chemistry
chemical_list: D000464:Alginates; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D006603:Hexuronic Acids; D008903:Minerals; D014867:Water; C028705:bone ash; D020723:Glucuronic Acid; D005780:Gelatin; D006820:Hyaluronic Acid
keywords: Bone ash; Drug delivery systems; Mechanical properties; Polymeric network; pH-sensitive release