title: [A survey of correlation between serum 25-hydroxyvitamin D levels and dyslipidemia rlsk among middle-aged individuals in Beijing].
abstract: OBJECTIVE
  To evaluate vitamin D status in middle-aged subjects in Beijing and explore the correlation between serum 25-hydroxyvitamin D[25(OH)D] levels and dyslipidemia.
  
  
  METHODS
  A total of 448 individuals over 40 years old were enrolled in the cross-sectional survey. The general information, blood biochemical and lipid profiles and serum 25(OH)D levels were collected. The subjects were either divided into two groups (the dyslipidemia group and the non-dyslipidemia group) based on the lipid levels, or four groups according to quartiles of 25(OH)D levels. The association between 25(OH)D levels and dyslipidemia risk was analyzed by a logistic regression analysis.
  
  
  RESULTS
  A total of 234 cases were in dyslipidemia group, which accounted for 52.23% of the subjects. The serum 25(OH)D levels were significantly lower in the dyslipidemia group than in the non-dyslipidemia group both in men and in women (all P<0.05). The median serum 25(OH)D level in the total subjects was 15.7 (12.2, 20.1)μg/L with 91.1% subjects of serum 25(OH)D level<30 μg/L. The proportion of subjects with dyslipidemia (high TC, high TG, high LDL-C, or low HDL-C) increased with the decrease of 25(OH)D level quartiles (P<0.05). After adjustment of confounding factors, the logistic regression analysis showed that subjects in the lowest 25(OH) D quartile group had 143% higher risks for dyslipidemia than those in the highest quartile group.
  
  
  CONCLUSIONS
  These findings indicate that 25(OH)D insufficiency is highly prevalent among middle-aged individuals and it may be associated with the risk of dyslipidemia.
authors.affiliation: Department of Geriatric Endocrinology, General Hospital of PLA, Beijing 100853, China.
authors.forename: L L
authors.initials: LL
authors.lastname: Zhang
authors.forename: Y H
authors.initials: YH
authors.lastname: Lu
authors.forename: X L
authors.initials: XL
authors.lastname: Cheng
authors.forename: M Y
authors.initials: MY
authors.lastname: Liu
authors.forename: B R
authors.initials: BR
authors.lastname: Sun
authors.forename: C L
authors.initials: CL
authors.lastname: Li
mesh_terms: D000368:Aged; D000068476:Beijing / Q000453:epidemiology; D003430:Cross-Sectional Studies; D050171:Dyslipidemias / Q000097:blood / Q000453:epidemiology / Q000209:etiology*; D005260:Female; D006801:Humans; D008055:Lipids / Q000097:blood*; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D011795:Surveys and Questionnaires; D014807:Vitamin D / Q000031:analogs & derivatives* / Q000097:blood
chemical_list: D008055:Lipids; D014807:Vitamin D; C104450:25-hydroxyvitamin D