title: Tanshinones and mental diseases: from chemistry to medicine.
abstract: The prevalence of mental diseases, especially neurodegenerative disorders, is ever-increasing, while treatment options for such disorders are limited and insufficient. In this scarcity of available medication, it is a feasible strategy to search for potential drugs among natural compounds, such as those found in plants. One such plant source is the root of Chinese sage, Salvia miltiorrhiza Bunge (Labiatae), which contains several compounds reported to possess neuroprotective activities. The most important of these compounds are tanshinones, which have been reported to possess ameliorative activity against a myriad of mental diseases such as Alzheimer's disease, cerebral ischemia/reperfusion injury, and glioma, along with promoting neuronal differentiation and manifesting antinociceptive and anticonvulsant outcomes. This review offers a critical evaluation of the utility of tanshinones to treat mental illnesses, and sheds light on the underlying mechanisms through which these naturally occurring compounds confer neuroprotection.
authors.forename: Sana
authors.initials: S
authors.lastname: Javed
authors.forename: Ameema
authors.initials: A
authors.lastname: Tariq
authors.forename: Touqeer
authors.initials: T
authors.lastname: Ahmed
authors.forename: Barbara
authors.initials: B
authors.lastname: Budzyńska
authors.forename: Silvia
authors.initials: S
authors.lastname: Tejada
authors.forename: Maria
authors.initials: M
authors.lastname: Daglia
authors.forename: Seyed Fazel
authors.initials: SF
authors.lastname: Nabavi
authors.forename: Eduardo
authors.initials: E
authors.lastname: Sobarzo-Sánchez
authors.forename: Seyed Mohammad
authors.initials: SM
authors.lastname: Nabavi
mesh_terms: D045784:Abietanes / Q000627:therapeutic use*; D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use*; D006801:Humans; D008516:Medicine, Chinese Traditional / Q000379:methods; D001523:Mental Disorders / Q000188:drug therapy*; D010616:Phenanthrenes / Q000627:therapeutic use*; D010936:Plant Extracts / Q000627:therapeutic use*
chemical_list: D045784:Abietanes; D000975:Antioxidants; D010616:Phenanthrenes; D010936:Plant Extracts; C021751:tanshinone