title: Efficacy of repetitive transcranial magnetic stimulation with quetiapine in treating bipolar II depression: a randomized, double-blinded, control study.
abstract: The clinical and cognitive responses to repetitive transcranial magnetic stimulation (rTMS) in bipolar II depressed patients remain unclear. In this study, thirty-eight bipolar II depressed patients were randomly assigned into three groups: (i) left high-frequency (n = 12), (ii) right low-frequency (n = 13), (iii) sham stimulation (n = 13), and underwent four-week rTMS with quetiapine concomitantly. Clinical efficacy was evaluated at baseline and weekly intervals using the 17-item Hamilton Depression Rating Scale (HDRS-17) and Montgomery-Asberg Depression Rating Scale (MADRS). Cognitive functioning was assessed before and after the study with the Wisconsin Card Sorting Test (WCST), Stroop Word-Color Interference Test (Stroop), and Trail Making Test (TMT). Thirty-five patients were included in the final analysis. Overall, the mean scores of both the HDRS-17 and the MADRS significantly decreased over the 4-week trial, which did not differ among the three groups. Exploratory analyses revealed no differences in factor scores of HDRS-17s, or in response or remission rates. Scores of WCST, Stroop, or TMT did not differ across the three groups. These findings indicated active rTMS combined with quetiapine was not superior to quetiapine monotherapy in improving depressive symptoms or cognitive performance in patients with bipolar II depression.
authors.affiliation: Department of Psychiatry, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China.|The Key Laboratory of Mental Disorder's Management of Zhejiang Province, Hangzhou 310003, China.
authors.forename: Shao-Hua
authors.initials: SH
authors.lastname: Hu
authors.affiliation: Zhejiang University School of Medicine, Hangzhou 310058, China.
authors.forename: Jian-Bo
authors.initials: JB
authors.lastname: Lai
authors.affiliation: Epidemiology Division &MRI Unit, Department of Psychiatry, Columbia University &New York State Psychiatric Institute, New York 10032, USA.
authors.forename: Dong-Rong
authors.initials: DR
authors.lastname: Xu
authors.affiliation: Department of Psychiatry, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China.|The Key Laboratory of Mental Disorder's Management of Zhejiang Province, Hangzhou 310003, China.
authors.forename: Hong-Li
authors.initials: HL
authors.lastname: Qi
authors.affiliation: Institute of the Developing Mind, Children's Hospital Los Angeles, University of Southern California, Los Angeles, California 90027, USA.
authors.forename: Bradley S
authors.initials: BS
authors.lastname: Peterson
authors.affiliation: The Key Laboratory of Mental Disorder's Management of Zhejiang Province, Hangzhou 310003, China.|Department of Neurobiology; Key Laboratory of Medical Neurobiology of Ministry of Health of China; Zhejiang Province Key Laboratory of Neurobiology, Zhejiang University School of Medicine, Hangzhou 310058, China.
authors.forename: Ai-Min
authors.initials: AM
authors.lastname: Bao
authors.affiliation: Department of Psychiatry, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China.|The Key Laboratory of Mental Disorder's Management of Zhejiang Province, Hangzhou 310003, China.
authors.forename: Chan-Chan
authors.initials: CC
authors.lastname: Hu
authors.affiliation: Department of Psychiatry, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China.|The Key Laboratory of Mental Disorder's Management of Zhejiang Province, Hangzhou 310003, China.
authors.forename: Man-Li
authors.initials: ML
authors.lastname: Huang
authors.affiliation: Department of Psychiatry, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China.|The Key Laboratory of Mental Disorder's Management of Zhejiang Province, Hangzhou 310003, China.
authors.forename: Jing-Kai
authors.initials: JK
authors.lastname: Chen
authors.affiliation: Department of Psychiatry, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China.|The Key Laboratory of Mental Disorder's Management of Zhejiang Province, Hangzhou 310003, China.
authors.forename: Ning
authors.initials: N
authors.lastname: Wei
authors.affiliation: Department of Psychiatry, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China.|The Key Laboratory of Mental Disorder's Management of Zhejiang Province, Hangzhou 310003, China.
authors.forename: Jian-Bo
authors.initials: JB
authors.lastname: Hu
authors.affiliation: Department of Psychiatry, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China.|The Key Laboratory of Mental Disorder's Management of Zhejiang Province, Hangzhou 310003, China.
authors.forename: Shu-Lan
authors.initials: SL
authors.lastname: Li
authors.affiliation: Department of Psychiatry, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China.|The Key Laboratory of Mental Disorder's Management of Zhejiang Province, Hangzhou 310003, China.
authors.forename: Wei-Hua
authors.initials: WH
authors.lastname: Zhou
authors.affiliation: Department of Psychiatry, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China.|The Key Laboratory of Mental Disorder's Management of Zhejiang Province, Hangzhou 310003, China.
authors.forename: Wei-Juan
authors.initials: WJ
authors.lastname: Xu
authors.affiliation: Department of Psychiatry, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China.|The Key Laboratory of Mental Disorder's Management of Zhejiang Province, Hangzhou 310003, China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Xu
mesh_terms: D000293:Adolescent; D000328:Adult; D014150:Antipsychotic Agents / Q000627:therapeutic use*; D001714:Bipolar Disorder / Q000188:drug therapy / Q000523:psychology / Q000628:therapy*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D000069348:Quetiapine Fumarate / Q000627:therapeutic use*; D050781:Transcranial Magnetic Stimulation / Q000379:methods*; D016896:Treatment Outcome
chemical_list: D014150:Antipsychotic Agents; D000069348:Quetiapine Fumarate