title: Effect of n-3 Polyunsaturated Fatty Acids on Regression of Coronary Atherosclerosis in Statin Treated Patients Undergoing Percutaneous Coronary Intervention.
abstract: OBJECTIVE
  Statins remain the mainstay of secondary coronary artery disease (CAD) prevention, but n-3 polyunsaturated fatty acids (ω-3 PUFA) display biological effects that may also reduce the risk of atherosclerosis and CAD. However, data on the possible antiatherosclerotic benefits of adding ω-3 PUFA to statin therapy are limited. This study aimed to investigate the potential additive effects of ω-3 PUFA on regression of atherosclerosis in CAD patients receiving statin therapy and stent implantation.
  
  
  METHODS
  Seventy-four CAD patients undergoing percutaneous coronary intervention (PCI) with stent implantation were enrolled, prescribed statins, and randomly assigned to two groups: n-3 group (ω-3 PUFA 3 g/day, n=38) or placebo group (placebo, n=36). All patients completed the study follow-up consisting of an intravascular ultrasound at baseline and at 12 months.
  
  
  RESULTS
  There was no difference in the baseline characteristics and distribution of other medications. No significant differences were observed in primary endpoints, including changes in atheroma volume index (-12.65% vs. -8.51%, p=0.768) and percent atheroma volume (-4.36% vs. -9.98%, p=0.526), and in secondary endpoints including a change in neointimal volume index (7.84 vs. 4.94 mm(3)/mm, p=0.087).
  
  
  CONCLUSIONS
  ω-3 PUFA had no definite additional effect on the regression of coronary atherosclerosis when added to statin in CAD patients undergoing PCI.
authors.affiliation: Division of Cardiology, Department of Internal Medicine, Pusan National University Hospital, Busan, Korea.
authors.forename: Jinhee
authors.initials: J
authors.lastname: Ahn
authors.affiliation: Division of Cardiology, Department of Internal Medicine, Pusan National University Hospital, Busan, Korea.
authors.forename: Seo Kwang
authors.initials: SK
authors.lastname: Park
authors.affiliation: Division of Cardiology, Department of Internal Medicine, Pusan National University Hospital, Busan, Korea.
authors.forename: Tae Sik
authors.initials: TS
authors.lastname: Park
authors.affiliation: Department of Internal Medicine, Busan Medical Center, Busan, Korea.
authors.forename: Jin Hee
authors.initials: JH
authors.lastname: Kim
authors.affiliation: Department of Biostatistics, Pusan National University Hospital, Busan, Korea.
authors.forename: Eunyoung
authors.initials: E
authors.lastname: Yun
authors.affiliation: Department of Cardiovascular Surgery, Pusan National University Hospital, Busan, Korea.
authors.forename: Sang-Pil
authors.initials: SP
authors.lastname: Kim
authors.affiliation: Division of Cardiology, Department of Internal Medicine, Pusan National University Hospital, Busan, Korea.
authors.forename: Hye Won
authors.initials: HW
authors.lastname: Lee
authors.affiliation: Division of Cardiology, Department of Internal Medicine, Pusan National University Hospital, Busan, Korea.
authors.forename: Jun-Hyok
authors.initials: JH
authors.lastname: Oh
authors.affiliation: Division of Cardiology, Department of Internal Medicine, Pusan National University Hospital, Busan, Korea.
authors.forename: Jung Hyun
authors.initials: JH
authors.lastname: Choi
authors.affiliation: Division of Cardiology, Department of Internal Medicine, Pusan National University Hospital, Busan, Korea.
authors.forename: Kwang Soo
authors.initials: KS
authors.lastname: Cha
authors.affiliation: Division of Cardiology, Department of Internal Medicine, Pusan National University Hospital, Busan, Korea.
authors.forename: Taek Jong
authors.initials: TJ
authors.lastname: Hong
authors.affiliation: Family Medicine Clinic and Research Institute of Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Yangsan, Korea.; Medical Education Unit and Medical Research Institute, Pusan National University School of Medicine, Yangsan, Korea.
authors.forename: Sang Yeoup
authors.initials: SY
authors.lastname: Lee
authors.affiliation: Division of Cardiology, Department of Internal Medicine, Pusan National University Hospital, Busan, Korea.
authors.forename: Han Cheol
authors.initials: HC
authors.lastname: Lee
keywords: Atherosclerosis; Coronary artery disease; Statin; n-3 polyunsaturated fatty acids