title: Triggering Intracellular Receptors for Vaccine Adjuvantation.
abstract: Immune adjuvants are components that stimulate, potentiate, or modulate the immune response to an antigen. They are key elements of vaccines in both the prophylactic and therapeutic domains. In the past decade substantial progress in our understanding of innate immunity has paved the way for the design of next-generation adjuvants that stimulate a wide range of receptors. Within the framework of vaccine adjuvant design, this review outlines the interest of targeting endosomal and intracellular receptors to enhance and guide the immune response. We present and compare the molecules as well as potential combinations which are currently in the spotlight. We emphasize how targeting the appropriate receptor can direct immunity towards the appropriate response, such as a cytotoxic or mucosal response.
authors.affiliation: Laboratoire de Biologie Tissulaire et d'Ingénierie Thérapeutique, Unité Mixte de Recherche 5305, Université Lyon 1, Centre National de la Recherche Scientifique (CNRS), Institut de Biologie et Chimie des Protéines (IBCP)-Lyon, France; InvivoGen, Toulouse, France; Groupe Immunité des Muqueuses et Agents Pathogènes, Institut National de la Santé et de la Recherche Médicale (INSERM) Centre d'Investigation Clinique 1408 Vaccinologie, Faculté de Médecine de Saint-Etienne-Saint-Etienne, France.
authors.forename: Alice
authors.initials: A
authors.lastname: Gutjahr
authors.affiliation: InvivoGen, Toulouse, France.
authors.forename: Gérard
authors.initials: G
authors.lastname: Tiraby
authors.affiliation: InvivoGen, Toulouse, France.
authors.forename: Eric
authors.initials: E
authors.lastname: Perouzel
authors.affiliation: Laboratoire de Biologie Tissulaire et d'Ingénierie Thérapeutique, Unité Mixte de Recherche 5305, Université Lyon 1, Centre National de la Recherche Scientifique (CNRS), Institut de Biologie et Chimie des Protéines (IBCP)-Lyon, France.
authors.forename: Bernard
authors.initials: B
authors.lastname: Verrier
authors.affiliation: Groupe Immunité des Muqueuses et Agents Pathogènes, Institut National de la Santé et de la Recherche Médicale (INSERM) Centre d'Investigation Clinique 1408 Vaccinologie, Faculté de Médecine de Saint-Etienne-Saint-Etienne, France. Electronic address: stephane.paul@chu-st-etienne.fr.
authors.forename: Stéphane
authors.initials: S
authors.lastname: Paul
mesh_terms: D000276:Adjuvants, Immunologic; D000818:Animals; D011992:Endosomes / Q000378:metabolism*; D006801:Humans; D007113:Immunity, Innate; D058990:Molecular Targeted Therapy; D015290:Second Messenger Systems / Q000276:immunology*; D015398:Signal Transduction; D014611:Vaccination; D014612:Vaccines / Q000276:immunology*
chemical_list: D000276:Adjuvants, Immunologic; D014612:Vaccines