title: Comparison of Clinical Outcomes ofBRCA1/2Pathologic Mutation, Variants of Unknown Significance, or Wild Type Epithelial Ovarian Cancer Patients.
abstract: OBJECTIVE
  The purpose of this study was to investigate the clinical features of epithelial ovarian cancer (EOC) patients according toBRCA1/2mutation status (mutation, variant of uncertain significance [VUS], or wild type).
  
  
  METHODS
  We analyzed 116 patients whoseBRCA1/2genetic test results were available for mutation type and clinical features, including progression-free survival (PFS), overall survival (OS), and response rate. These characteristics were compared according toBRCA1/2mutation status.
  
  
  RESULTS
  Thirty-seven (37/116, 31.9%)BRCA1/2mutations were identified (BRCA1, 30;BRCA2, 7). Mutation of c.3627_3628insA (p.Leu1209_Glu1210?fs) inBRCA1was observed in five patients (5/37, 13.5%). Twenty-five patients hadBRCA1/2VUSs (25/116, 21.6%). Personal histories of breast cancer were observed in 48.6% of patients withBRCA1/2mutation (18/37), 16.0% of patients withBRCA1/2VUS (4/25), and 7.4% of patients withBRCAwild type (4/54) (p < 0.001). Patients withBRCA1/2mutation showed longer OS than those withBRCA1/2wild type (p=0.005). No significant differences were detected in PFS, OS, or response rates between patients withBRCA1/2VUS andBRCA1/2mutation (p=0.772, p=0.459, and p=0.898, respectively).
  
  
  CONCLUSIONS
  PatientswithBRCA1/2mutation had longer OS than thosewithBRCA1/2wild type. Patients withBRCA1/2mutation andBRCA1/2VUS displayed similar prognoses.
authors.affiliation: Department of Obstetrics and Gynecology, Institute of Women's Life Medical Science, Women's Cancer Clinic, Yonsei University College of Medicine, Seoul, Korea.
authors.forename: Kyung Jin
authors.initials: KJ
authors.lastname: Eoh
authors.affiliation: Hereditary Cancer Clinic of Cancer Prevention Center, Yonsei Cancer Center, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.|Department of Surgery, Yonsei University College of Medicine, Seoul, Korea.
authors.forename: Hyung Seok
authors.initials: HS
authors.lastname: Park
authors.affiliation: Hereditary Cancer Clinic of Cancer Prevention Center, Yonsei Cancer Center, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.|Cancer Prevention Center, Yonsei Cancer Center, Seoul, Korea.
authors.forename: Ji Soo
authors.initials: JS
authors.lastname: Park
authors.affiliation: Hereditary Cancer Clinic of Cancer Prevention Center, Yonsei Cancer Center, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.|Department of Laboratory Medicine, Yonsei University College of Medicine, Seoul, Korea.
authors.forename: Seung-Tae
authors.initials: ST
authors.lastname: Lee
authors.affiliation: Hereditary Cancer Clinic of Cancer Prevention Center, Yonsei Cancer Center, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.|Department of Pediatrics, Yonsei University College of Medicine, Seoul, Korea.
authors.forename: Jeongwoo
authors.initials: J
authors.lastname: Han
authors.affiliation: Department of Obstetrics and Gynecology, Institute of Women's Life Medical Science, Women's Cancer Clinic, Yonsei University College of Medicine, Seoul, Korea.
authors.forename: Jung-Yun
authors.initials: JY
authors.lastname: Lee
authors.affiliation: Department of Obstetrics and Gynecology, Institute of Women's Life Medical Science, Women's Cancer Clinic, Yonsei University College of Medicine, Seoul, Korea.
authors.forename: Sang Wun
authors.initials: SW
authors.lastname: Kim
authors.affiliation: Department of Obstetrics and Gynecology, Institute of Women's Life Medical Science, Women's Cancer Clinic, Yonsei University College of Medicine, Seoul, Korea.
authors.forename: Sunghoon
authors.initials: S
authors.lastname: Kim
authors.affiliation: Department of Obstetrics and Gynecology, Institute of Women's Life Medical Science, Women's Cancer Clinic, Yonsei University College of Medicine, Seoul, Korea.
authors.forename: Young Tae
authors.initials: YT
authors.lastname: Kim
authors.affiliation: Department of Obstetrics and Gynecology, Institute of Women's Life Medical Science, Women's Cancer Clinic, Yonsei University College of Medicine, Seoul, Korea.|Hereditary Cancer Clinic of Cancer Prevention Center, Yonsei Cancer Center, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.
authors.forename: Eun Ji
authors.initials: EJ
authors.lastname: Nam
mesh_terms: D000328:Adult; D000368:Aged; D000483:Alleles; D000077216:Carcinoma, Ovarian Epithelial; D003131:Combined Modality Therapy; D005260:Female; D019398:Genes, BRCA1; D024522:Genes, BRCA2; D006801:Humans; D008875:Middle Aged; D064847:Multimodal Imaging / Q000379:methods; D009154:Mutation; D060787:Neoplasm Grading; D009367:Neoplasm Staging; D009375:Neoplasms, Glandular and Epithelial / Q000175:diagnosis / Q000235:genetics* / Q000401:mortality* / Q000628:therapy; D010051:Ovarian Neoplasms / Q000175:diagnosis / Q000235:genetics* / Q000401:mortality* / Q000628:therapy; D011379:Prognosis; D017422:Sequence Analysis, DNA; D016019:Survival Analysis; D016896:Treatment Outcome
keywords: BRCA1; BRCA2; Ovarian epithelial cancer; Prognosis