title: PHARMACOKINETIC EVALUATION OF A LONG-ACTING FENTANYL SOLUTION AFTER TRANSDERMAL ADMINISTRATION IN HELMETED GUINEAFOWL (NUMIDA MELEAGRIS).
abstract: The objective of this study was to investigate the pharmacokinetics of a long-acting fentanyl solution in helmeted guineafowl ( Numida meleagris ) after transdermal administration. Twenty-one guineafowl received a single administration of 5 mg/kg of fentanyl transdermal solution. No adverse effects on behavior were appreciated. Plasma fentanyl concentrations were determined by liquid chromatography-mass spectrometry analysis of protein-precipitated samples. Mean maximum plasma concentration was 228.8 ng/ml at 4 hr. The mean plasma terminal half-life was 33.2 hr. At 168 hr the mean plasma concentration was 1.3 ng/ml. A single topical dose of 5 mg/kg appears to be safe for use in this species and maintained plasma concentrations above those reported to be analgesic in dogs for at least 7 days.
authors.forename: Lynnette
authors.initials: L
authors.lastname: Waugh
authors.forename: Heather
authors.initials: H
authors.lastname: Knych
authors.forename: Gretchen
authors.initials: G
authors.lastname: Cole
authors.forename: Jennifer
authors.initials: J
authors.lastname: D'Agostino
mesh_terms: D000279:Administration, Cutaneous; D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000493:pharmacokinetics*; D019540:Area Under Curve; D003692:Delayed-Action Preparations; D005260:Female; D005283:Fentanyl / Q000008:administration & dosage / Q000493:pharmacokinetics*; D046094:Galliformes / Q000097:blood*; D006207:Half-Life; D008297:Male
chemical_list: D000900:Anti-Bacterial Agents; D003692:Delayed-Action Preparations; D005283:Fentanyl
keywords: Analgesia; Numida meleagris; Recuvyra™; avian; fentanyl solution; guineafowl