title: Lidocaine decreases the xylazine-evoked contractility in pregnant cows.
abstract: The objective of this in vitro study was to evaluate and compare the effects of xylazine on basal uterine contractility of bovine pregnant uterine strips and that of lidocaine on xylazine-sensitized bovine pregnant uterine strips, at different stages of pregnancy. Basal contractility was evaluated in an isolated organ bath and the functionality of the strips throughout the experiment was evaluated using a dose of carbachol (10(-5)M). Uterine motility, expressed with amplitude, frequency of contractions as well as the area under the curve, was recorded in different stages of pregnancy and data were collected at 15-min intervals (5-min before and 5-min after xylazine administration and 5-min after lidocaine addition on the plateau contraction induced by xylazine). Uterine motility increased in all the stages of pregnancy after xylazine addition and gradually decreased after treatment with lidocaine. These data suggest that lidocaine might decrease the tonic effect induced by xylazine on bovine pregnant uteri.
authors.affiliation: Department of Emergency and Organ Transplantation, Section of Veterinary Medicine and Animal Production, University of Bari Aldo Moro, S.P. per Casamassima km. 3, 70010 Valenzano, BA, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Piccinno
authors.affiliation: Department of Emergency and Organ Transplantation, Section of Veterinary Medicine and Animal Production, University of Bari Aldo Moro, S.P. per Casamassima km. 3, 70010 Valenzano, BA, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Rizzo
authors.affiliation: Department of Emergency and Organ Transplantation, Section of Veterinary Medicine and Animal Production, University of Bari Aldo Moro, S.P. per Casamassima km. 3, 70010 Valenzano, BA, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Mutinati
authors.affiliation: Self-employed Professional, Noci, Bari, Italy.
authors.forename: G
authors.initials: G
authors.lastname: D'Onghia
authors.affiliation: Department of Emergency and Organ Transplantation, Section of Veterinary Medicine and Animal Production, University of Bari Aldo Moro, S.P. per Casamassima km. 3, 70010 Valenzano, BA, Italy. Electronic address: raffaeleluigi.sciorsci@uniba.it.
authors.forename: R L
authors.initials: RL
authors.lastname: Sciorsci
mesh_terms: D000779:Anesthetics, Local / Q000008:administration & dosage / Q000494:pharmacology; D000818:Animals; D002217:Carbachol / Q000494:pharmacology; D002417:Cattle; D004359:Drug Therapy, Combination; D005260:Female; D008012:Lidocaine / Q000008:administration & dosage / Q000494:pharmacology*; D011247:Pregnancy; D046509:Tissue Culture Techniques; D014590:Uterine Contraction / Q000187:drug effects*; D014599:Uterus / Q000187:drug effects / Q000502:physiology; D014991:Xylazine / Q000008:administration & dosage / Q000494:pharmacology*
chemical_list: D000779:Anesthetics, Local; D014991:Xylazine; D002217:Carbachol; D008012:Lidocaine
keywords: Cattle; Lidocaine; Pregnancy stages; Uterine contractility; Xylazine