title: Adult-onset opsoclonus-myoclonus syndrome due to West Nile Virus treated with intravenous immunoglobulin.
abstract: A 63-year-old female with no significant past medical history was presented with a 5-day history of progressive opsoclonus-myoclonus, headaches, and fevers. Her workup was significant only for positive West-Nile Virus serum serologies. She received a 2-day course of intravenous immunoglobulin (IvIG). At an 8-week follow up, she had a complete neurological remission. Adult-onset opsoclonus-myoclonus syndrome is a rare condition for which paraneoplastic and infectious causes have been attributed. To our knowledge, this is the first case reported of opsoclonus-myoclonus secondary to West-Nile Virus treated with intravenous immunoglobulin monotherapy.
authors.affiliation: Division of Neurology, University of Toronto, Toronto, ON, Canada.
authors.forename: Julien
authors.initials: J
authors.lastname: Hébert
authors.affiliation: Faculty of Medicine, University of Toronto, Toronto, ON, Canada.
authors.forename: David
authors.initials: D
authors.lastname: Armstrong
authors.affiliation: Division of Infectious Diseases, Sunnybrook Health Sciences Center, Toronto, ON, Canada.|Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, ON, Canada.
authors.forename: Nick
authors.initials: N
authors.lastname: Daneman
authors.affiliation: Division of Neurology, Sunnybrook Health Sciences Center, A402, 2075 Bayview avenue, Toronto, ON, Canada, M4N 3M5.
authors.forename: Jennifer Deborah
authors.initials: JD
authors.lastname: Jain
authors.affiliation: Division of Neurology, Sunnybrook Health Sciences Center, A402, 2075 Bayview avenue, Toronto, ON, Canada, M4N 3M5. james.perry@sunnybrook.ca.
authors.forename: James
authors.initials: J
authors.lastname: Perry
mesh_terms: D005260:Female; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use*; D008875:Middle Aged; D053578:Opsoclonus-Myoclonus Syndrome / Q000175:diagnosis / Q000188:drug therapy* / Q000209:etiology / Q000276:immunology; D016896:Treatment Outcome; D014901:West Nile Fever / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy* / Q000276:immunology; D014902:West Nile virus / Q000276:immunology* / Q000302:isolation & purification / Q000472:pathogenicity
chemical_list: D016756:Immunoglobulins, Intravenous
keywords: Opsoclonus-myoclonus syndrome; West Nile virus