title: Fucoidans in Nanomedicine.
abstract: Fucoidans are widespread cost-effective sulfated marine polysaccharides which have raised interest in the scientific community over last decades for their wide spectrum of bioactivities. Unsurprisingly, nanomedicine has grasped these compounds to develop innovative therapeutic and diagnostic nanosystems. The applications of fucoidans in nanomedicine as imaging agents, drug carriers or for their intrinsic properties are reviewed here after a short presentation of the main structural data and biological properties of fucoidans. The origin and the physicochemical specifications of fucoidans are summarized in order to discuss the strategy of fucoidan-containing nanosystems in Human health. Currently, there is a need for reproducible, well characterized fucoidan fractions to ensure significant progress.
authors.affiliation: Inserm, U1148, LVTS, University Paris Diderot, X Bichat Hospital, F-75877 Paris, France. lucas.chollet@algues-et-mer.com.|Galil&#233;e Institute, University Paris 13, Sorbonne Paris Cit&#233;, F-93430 Villetaneuse, France. lucas.chollet@algues-et-mer.com.|Algues &amp; Mer, Kernigou, F-29242 Ouessant, France. lucas.chollet@algues-et-mer.com.
authors.forename: Lucas
authors.initials: L
authors.lastname: Chollet
authors.affiliation: Inserm, U1148, LVTS, University Paris Diderot, X Bichat Hospital, F-75877 Paris, France. pierre.saboural@univ-paris13.fr.|Galil&#233;e Institute, University Paris 13, Sorbonne Paris Cit&#233;, F-93430 Villetaneuse, France. pierre.saboural@univ-paris13.fr.
authors.forename: Pierre
authors.initials: P
authors.lastname: Saboural
authors.affiliation: Inserm, U1148, LVTS, University Paris Diderot, X Bichat Hospital, F-75877 Paris, France. cedric.chauvierre@inserm.fr.|Galil&#233;e Institute, University Paris 13, Sorbonne Paris Cit&#233;, F-93430 Villetaneuse, France. cedric.chauvierre@inserm.fr.
authors.forename: Cédric
authors.initials: C
authors.lastname: Chauvierre
authors.affiliation: Algues &amp; Mer, Kernigou, F-29242 Ouessant, France. jn.villemin@algues-et-mer.com.
authors.forename: Jean-Noël
authors.initials: JN
authors.lastname: Villemin
authors.affiliation: Inserm, U1148, LVTS, University Paris Diderot, X Bichat Hospital, F-75877 Paris, France. didier.letourneur@inserm.fr.|Galil&#233;e Institute, University Paris 13, Sorbonne Paris Cit&#233;, F-93430 Villetaneuse, France. didier.letourneur@inserm.fr.
authors.forename: Didier
authors.initials: D
authors.lastname: Letourneur
authors.affiliation: Inserm, U1148, LVTS, University Paris Diderot, X Bichat Hospital, F-75877 Paris, France. frederic.chaubet@univ-paris13.fr.|Galil&#233;e Institute, University Paris 13, Sorbonne Paris Cit&#233;, F-93430 Villetaneuse, France. frederic.chaubet@univ-paris13.fr.
authors.forename: Frédéric
authors.initials: F
authors.lastname: Chaubet
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology; D000925:Anticoagulants / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000494:pharmacology; D000975:Antioxidants / Q000494:pharmacology; D000998:Antiviral Agents / Q000494:pharmacology; D003287:Contrast Media / Q000494:pharmacology; D004337:Drug Carriers / Q000494:pharmacology; D006801:Humans; D007004:Hypoglycemic Agents / Q000494:pharmacology; D015394:Molecular Structure; D050997:Nanomedicine; D000459:Phaeophyceae / Q000737:chemistry*; D011134:Polysaccharides / Q000494:pharmacology*; D012616:Sea Cucumbers / Q000737:chemistry*; D012617:Sea Urchins / Q000737:chemistry*; D012624:Seaweed / Q000737:chemistry*; D013463:Sulfuric Acid Esters / Q000494:pharmacology*
chemical_list: D000893:Anti-Inflammatory Agents; D000925:Anticoagulants; D000970:Antineoplastic Agents; D000975:Antioxidants; D000998:Antiviral Agents; D003287:Contrast Media; D004337:Drug Carriers; D007004:Hypoglycemic Agents; D011134:Polysaccharides; D013463:Sulfuric Acid Esters; C007789:fucoidan
keywords: drug delivery; fucoidans; imaging agent; nanomedicine; nanosystems; sulfated polysaccharides; tissue regeneration