title: G6PD Deficiency Does Not Enhance Susceptibility for Acquiring Helicobacter pylori Infection in Sardinian Patients.
abstract: BACKGROUND
  Subjects with glucose-6-phosphate dehydrogenase (G6PD) deficiency may be more susceptible to infections due to impaired leukocyte bactericidal activity. The disorder is common in the Mediterranean area. The aim of this study was to investigate whether G6PD deficiency may be a risk factor for acquiring H. pylori infection.
  
  
  METHODS
  We performed a retrospective study. Data from clinical records of 6565 patients (2278 men and 4287 women, median age 51, range 7‒94) who underwent upper endoscopy between 2002 and 2014 were collected. H. pylori status, assessed by histology plus rapid urease test or 13C-urea breath test, and G6PD status were also reported. A multiple logistic regression model was used to investigate the association between G6PD deficiency and H. pylori infection.
  
  
  RESULTS
  Enzyme deficiency was detected in 12% (789/6565) of the entire cohort, and more specifically in 8.3% of men and in 14.0% of women. Overall, the proportion of patients positive for H. pylori was 50.6% and 51.5% among G6PD deficient and non-deficient patients (χ² = 0.271; p = 0.315). Moreover, among G6PD-deficient and normal patients the frequency of previous H. pylori infection was similar. After adjustment for age and gender the risk for acquiring H. pylori infection was similar in G6PD-deficient and normal patients. Only age was a strong statistically significant risk predictor.
  
  
  CONCLUSIONS
  These results demonstrate for the first time that G6PD deficiency does not enhance patients' susceptibility to acquire H. pylori infection in Sardinia.
authors.affiliation: Dipartimento di Medicina Clinica e Sperimentale, University of Sassari, Sassari, Italy.|Baylor College of Medicine, Houston, Texas, United States of America.
authors.forename: Maria Pina
authors.initials: MP
authors.lastname: Dore
authors.affiliation: Dipartimento di Medicina Clinica e Sperimentale, University of Sassari, Sassari, Italy.
authors.forename: Giuseppina
authors.initials: G
authors.lastname: Marras
authors.affiliation: Dipartimento di Medicina Clinica e Sperimentale, University of Sassari, Sassari, Italy.
authors.forename: Chiara
authors.initials: C
authors.lastname: Rocchi
authors.affiliation: Dipartimento di Medicina Clinica e Sperimentale, University of Sassari, Sassari, Italy.
authors.forename: Sara
authors.initials: S
authors.lastname: Soro
authors.affiliation: Dipartimento di Medicina Clinica e Sperimentale, University of Sassari, Sassari, Italy.|Istituto Nazionale Biostrutture e Biosistemi, Sassari, Italy.
authors.forename: Giovanni Mario
authors.identifier: http://orcid.org/0000-0003-3265-2823
authors.initials: GM
authors.lastname: Pes
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D005955:Glucosephosphate Dehydrogenase Deficiency / Q000150:complications*; D016481:Helicobacter Infections / Q000150:complications / Q000235:genetics* / Q000382:microbiology; D016480:Helicobacter pylori / Q000302:isolation & purification*; D006801:Humans; D007558:Italy; D008297:Male; D008875:Middle Aged