title: p53 mutations promote proteasomal activity.
abstract: p53 mutations occur very frequently in human cancer. Besides abrogating the tumour suppressive functions of wild-type p53, many of those mutations also acquire oncogenic gain-of-function activities. Augmentation of proteasome activity is now reported as a common gain-of-function mechanism shared by different p53 mutants, which promotes cancer resistance to proteasome inhibitors.
authors.affiliation: Department of Molecular Cell Biology, The Weizmann Institute, Rehovot 76100, Israel.
authors.forename: Moshe
authors.initials: M
authors.lastname: Oren
authors.affiliation: Department of Molecular Cell Biology, The Weizmann Institute, Rehovot 76100, Israel.
authors.forename: Eran
authors.initials: E
authors.lastname: Kotler
mesh_terms: D000818:Animals; D015972:Gene Expression Regulation, Neoplastic / Q000187:drug effects / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D006801:Humans; D009154:Mutation / Q000235:genetics*; D009369:Neoplasms / Q000235:genetics*; D061988:Proteasome Inhibitors / Q000494:pharmacology; D016159:Tumor Suppressor Protein p53 / Q000235:genetics*
chemical_list: D061988:Proteasome Inhibitors; D016159:Tumor Suppressor Protein p53