title: Biomedical Applications of Quantum Dots, Nucleic Acid-Based Aptamers, and Nanostructures in Biosensors.
abstract: This review is a survey of the biomedical applications of semiconductor quantum dots, nucleic acid-based aptamers, and nanosensors as molecular biosensors. It focuses on the detection of analytes in biomedical applications using (1) advances in molecular beacons incorporating semiconductor quantum dots and nanoscale quenching elements; (2) aptamer-based nanosensors on a variety of platforms, including graphene; (3) Raman scattering and surface-enhanced Raman scattering (SERS) using nanostructures for enhanced SERS spectra of biomolecules, including aptamers; and (4) the electrical and optical properties of nanostructures incorporated into molecular beacons and aptamer-based nanosensors. Research done at the University of Illinois at Chicago (UIC) is highlighted throughout since it emphasizes the specific approaches taken by the bioengineering department at UIC.
authors.affiliation: Bioengineering Department, University of Illinois at Chicago.
authors.forename: Xenia
authors.initials: X
authors.lastname: Meshik
authors.affiliation: Electrical & Computer Engineering Department, University of Illinois at Chicago.
authors.forename: Sidra
authors.initials: S
authors.lastname: Farid
authors.affiliation: Electrical & Computer Engineering Department, University of Illinois at Chicago.
authors.forename: Min
authors.initials: M
authors.lastname: Choi
authors.affiliation: Electrical & Computer Engineering Department, University of Illinois at Chicago.
authors.forename: Yi
authors.initials: Y
authors.lastname: Lan
authors.affiliation: Electrical & Computer Engineering Department, University of Illinois at Chicago.
authors.forename: Souvik
authors.initials: S
authors.lastname: Mukherjee
authors.affiliation: Electrical & Computer Engineering Department, University of Illinois at Chicago.
authors.forename: Debopam
authors.initials: D
authors.lastname: Datta
authors.affiliation: Bioengineering Department, University of Illinois at Chicago; Physics Department, University of Illinois at Chicago.
authors.forename: Mitra
authors.initials: M
authors.lastname: Dutta
authors.affiliation: Bioengineering Department, University of Illinois at Chicago; Electrical & Computer Engineering Department, University of Illinois at Chicago; Physics Department, University of Illinois at Chicago.
authors.forename: Michael A
authors.initials: MA
authors.lastname: Stroscio
mesh_terms: D052157:Aptamers, Nucleotide; D015374:Biosensing Techniques / Q000379:methods*; D049329:Nanostructures; D009696:Nucleic Acids / Q000737:chemistry*; D045663:Quantum Dots
chemical_list: D052157:Aptamers, Nucleotide; D009696:Nucleic Acids