title: Radiation driven epithelial-mesenchymal transition is mediated by Notch signaling in breast cancer.
abstract: Epithelial to mesenchymal transition (EMT) is developmental process associated with cancer metastasis. Here, we found that breast carcinoma cells adopt epithelial-to-mesenchymal transition (EMT) in response to fractionated-radiation. Importantly, we show that Notch signaling is highly activated in fractionally-irradiated tumors as compared to non-irradiated tumors that are accompanied by an EMT. Moreover, we uncovered the mechanism of Notch-driven EMT, in which Notch enhanced EMT through IL-6/JAK/STAT3 signaling axis in mammary tumor cells. Collectively, we present converging evidence from our studies that Notch2 is a critical mediator of radiation-induced EMT and responsible for induced malignant tumor growth.
authors.affiliation: Department of Life Science, College of Natural Sciences, Hanyang University, Seoul, Korea.
authors.forename: Rae-Kwon
authors.initials: RK
authors.lastname: Kim
authors.affiliation: Department of Life Science, College of Natural Sciences, Hanyang University, Seoul, Korea.
authors.forename: Neha
authors.initials: N
authors.lastname: Kaushik
authors.affiliation: Department of Life Science, College of Natural Sciences, Hanyang University, Seoul, Korea.
authors.forename: Yongjoon
authors.initials: Y
authors.lastname: Suh
authors.affiliation: Department of Life Science, College of Natural Sciences, Hanyang University, Seoul, Korea.
authors.forename: Ki-Chun
authors.initials: KC
authors.lastname: Yoo
authors.affiliation: Department of Life Science, College of Natural Sciences, Hanyang University, Seoul, Korea.
authors.forename: Yan-Hong
authors.initials: YH
authors.lastname: Cui
authors.affiliation: Laboratory of Radiation Exposure and Therapeutics, National Radiation Emergency Medical Center, Korea Institute of Radiological and Medical Sciences, Seoul, Korea.
authors.forename: Min-Jung
authors.initials: MJ
authors.lastname: Kim
authors.affiliation: Division of Radiation Effect, Korea Institute of Radiological and Medical Sciences, Seoul, Korea.
authors.forename: Hae-June
authors.initials: HJ
authors.lastname: Lee
authors.affiliation: Department of Radiation Biology, Environmental Radiation Research Group, Korea Atomic Energy Research Institute, Daejeon, Korea.
authors.forename: In-Gyu
authors.initials: IG
authors.lastname: Kim
authors.affiliation: Department of Life Science, College of Natural Sciences, Hanyang University, Seoul, Korea.
authors.forename: Su-Jae
authors.initials: SJ
authors.lastname: Lee
mesh_terms: D000818:Animals; D001943:Breast Neoplasms / Q000378:metabolism / Q000473:pathology*; D045744:Cell Line, Tumor; D019583:Dose Fractionation, Radiation; D058750:Epithelial-Mesenchymal Transition / Q000528:radiation effects*; D005260:Female; D064593:Heterografts; D006801:Humans; D051379:Mice; D008807:Mice, Inbred BALB C; D011878:Radiotherapy / Q000009:adverse effects; D051883:Receptor, Notch2 / Q000378:metabolism*; D015398:Signal Transduction / Q000528:radiation effects*
chemical_list: C497764:NOTCH2 protein, human; D051883:Receptor, Notch2
keywords: EMT; Notch signaling; breast cancer; interleukin-6; radiation