title: Temporal T807 binding correlates with CSF tau and phospho-tau in normal elderly.
abstract: OBJECTIVE
  To better understand cross-sectional relationships between CSF and PET measures of tau pathology, we compared regional and global measures of (18)F-T807 (AV-1451) PET to CSF protein levels of total tau (t-tau), phosphorylated tau (p-tau), and β-amyloid 1-42 (Aβ42).
  
  
  METHODS
  T-tau, p-tau, and Aβ42 levels were assessed using INNOTEST xMAP immunoassays. Linear regression was used to compare regional and global measures of (18)F-T807 standardized uptake value ratios (SUVR) to CSF protein levels using data from 31 cognitively unimpaired elderly participants in the Harvard Aging Brain study.
  
  
  RESULTS
  After controlling for sex and age, total cortical (18)F-T807 binding was significantly correlated with p-tau (partial r = 0.48; p < 0.01) and at trend level with t-tau (partial r = 0.30; p = 0.12). Regional (18)F-T807 measures were more strongly correlated with CSF protein levels than the global measure, with both t-tau and p-tau significantly correlated with (18)F-T807 SUVR in entorhinal, parahippocampal, and inferior temporal cortical regions (partial r = 0.53-0.73). Peak correlations between CSF and PET measures of tau were similar to those between CSF and PET measures of amyloid burden. Finally, we observed significantly higher temporal T807 SUVR in individuals with high amyloid burden.
  
  
  CONCLUSIONS
  These data support the link between (18)F-T807 PET and CSF measures of tau pathology. In these cognitively normal individuals with (18)F-T807 binding largely restricted to the temporal lobe, (18)F-T807 SUVR in temporal regions appeared more reflective of CSF t-tau and p-tau than a total cortical measure.
authors.affiliation: From Harvard Medical School (J.P.C., A.P.S., G.A.M., B.B., T.G.-I., C.S., B.T.H., R.A.S., K.A.J.); Massachusetts General Hospital (J.P.C., A.P.S., G.A.M., B.B., T.G.-I., J.D., M.L., A.D.R., B.T.H., R.A.S., K.A.J.), Boston; Martinos Center for Biomedical Imaging (J.P.C., A.P.S., M.L., R.A.S., K.A.J.), Charlestown; Brigham and Women's Hospital (G.A.M., B.B., C.S., R.A.S., K.A.J.), Boston; Biogen (B.B.), Cambridge, MA; Lariboisiere Hospital Memory Center (J.D.), APHP, University Paris 7 Denis Diderot, France; and Harvard NeuroDiscovery Center (C.S.), Boston, MA.
authors.forename: Jasmeer P
authors.initials: JP
authors.lastname: Chhatwal
authors.affiliation: From Harvard Medical School (J.P.C., A.P.S., G.A.M., B.B., T.G.-I., C.S., B.T.H., R.A.S., K.A.J.); Massachusetts General Hospital (J.P.C., A.P.S., G.A.M., B.B., T.G.-I., J.D., M.L., A.D.R., B.T.H., R.A.S., K.A.J.), Boston; Martinos Center for Biomedical Imaging (J.P.C., A.P.S., M.L., R.A.S., K.A.J.), Charlestown; Brigham and Women's Hospital (G.A.M., B.B., C.S., R.A.S., K.A.J.), Boston; Biogen (B.B.), Cambridge, MA; Lariboisiere Hospital Memory Center (J.D.), APHP, University Paris 7 Denis Diderot, France; and Harvard NeuroDiscovery Center (C.S.), Boston, MA.
authors.forename: Aaron P
authors.initials: AP
authors.lastname: Schultz
authors.affiliation: From Harvard Medical School (J.P.C., A.P.S., G.A.M., B.B., T.G.-I., C.S., B.T.H., R.A.S., K.A.J.); Massachusetts General Hospital (J.P.C., A.P.S., G.A.M., B.B., T.G.-I., J.D., M.L., A.D.R., B.T.H., R.A.S., K.A.J.), Boston; Martinos Center for Biomedical Imaging (J.P.C., A.P.S., M.L., R.A.S., K.A.J.), Charlestown; Brigham and Women's Hospital (G.A.M., B.B., C.S., R.A.S., K.A.J.), Boston; Biogen (B.B.), Cambridge, MA; Lariboisiere Hospital Memory Center (J.D.), APHP, University Paris 7 Denis Diderot, France; and Harvard NeuroDiscovery Center (C.S.), Boston, MA.
authors.forename: Gad A
authors.initials: GA
authors.lastname: Marshall
authors.affiliation: From Harvard Medical School (J.P.C., A.P.S., G.A.M., B.B., T.G.-I., C.S., B.T.H., R.A.S., K.A.J.); Massachusetts General Hospital (J.P.C., A.P.S., G.A.M., B.B., T.G.-I., J.D., M.L., A.D.R., B.T.H., R.A.S., K.A.J.), Boston; Martinos Center for Biomedical Imaging (J.P.C., A.P.S., M.L., R.A.S., K.A.J.), Charlestown; Brigham and Women's Hospital (G.A.M., B.B., C.S., R.A.S., K.A.J.), Boston; Biogen (B.B.), Cambridge, MA; Lariboisiere Hospital Memory Center (J.D.), APHP, University Paris 7 Denis Diderot, France; and Harvard NeuroDiscovery Center (C.S.), Boston, MA.
authors.forename: Brendon
authors.initials: B
authors.lastname: Boot
authors.affiliation: From Harvard Medical School (J.P.C., A.P.S., G.A.M., B.B., T.G.-I., C.S., B.T.H., R.A.S., K.A.J.); Massachusetts General Hospital (J.P.C., A.P.S., G.A.M., B.B., T.G.-I., J.D., M.L., A.D.R., B.T.H., R.A.S., K.A.J.), Boston; Martinos Center for Biomedical Imaging (J.P.C., A.P.S., M.L., R.A.S., K.A.J.), Charlestown; Brigham and Women's Hospital (G.A.M., B.B., C.S., R.A.S., K.A.J.), Boston; Biogen (B.B.), Cambridge, MA; Lariboisiere Hospital Memory Center (J.D.), APHP, University Paris 7 Denis Diderot, France; and Harvard NeuroDiscovery Center (C.S.), Boston, MA.
authors.forename: Teresa
authors.initials: T
authors.lastname: Gomez-Isla
authors.affiliation: From Harvard Medical School (J.P.C., A.P.S., G.A.M., B.B., T.G.-I., C.S., B.T.H., R.A.S., K.A.J.); Massachusetts General Hospital (J.P.C., A.P.S., G.A.M., B.B., T.G.-I., J.D., M.L., A.D.R., B.T.H., R.A.S., K.A.J.), Boston; Martinos Center for Biomedical Imaging (J.P.C., A.P.S., M.L., R.A.S., K.A.J.), Charlestown; Brigham and Women's Hospital (G.A.M., B.B., C.S., R.A.S., K.A.J.), Boston; Biogen (B.B.), Cambridge, MA; Lariboisiere Hospital Memory Center (J.D.), APHP, University Paris 7 Denis Diderot, France; and Harvard NeuroDiscovery Center (C.S.), Boston, MA.
authors.forename: Julien
authors.initials: J
authors.lastname: Dumurgier
authors.affiliation: From Harvard Medical School (J.P.C., A.P.S., G.A.M., B.B., T.G.-I., C.S., B.T.H., R.A.S., K.A.J.); Massachusetts General Hospital (J.P.C., A.P.S., G.A.M., B.B., T.G.-I., J.D., M.L., A.D.R., B.T.H., R.A.S., K.A.J.), Boston; Martinos Center for Biomedical Imaging (J.P.C., A.P.S., M.L., R.A.S., K.A.J.), Charlestown; Brigham and Women's Hospital (G.A.M., B.B., C.S., R.A.S., K.A.J.), Boston; Biogen (B.B.), Cambridge, MA; Lariboisiere Hospital Memory Center (J.D.), APHP, University Paris 7 Denis Diderot, France; and Harvard NeuroDiscovery Center (C.S.), Boston, MA.
authors.forename: Molly
authors.initials: M
authors.lastname: LaPoint
authors.affiliation: From Harvard Medical School (J.P.C., A.P.S., G.A.M., B.B., T.G.-I., C.S., B.T.H., R.A.S., K.A.J.); Massachusetts General Hospital (J.P.C., A.P.S., G.A.M., B.B., T.G.-I., J.D., M.L., A.D.R., B.T.H., R.A.S., K.A.J.), Boston; Martinos Center for Biomedical Imaging (J.P.C., A.P.S., M.L., R.A.S., K.A.J.), Charlestown; Brigham and Women's Hospital (G.A.M., B.B., C.S., R.A.S., K.A.J.), Boston; Biogen (B.B.), Cambridge, MA; Lariboisiere Hospital Memory Center (J.D.), APHP, University Paris 7 Denis Diderot, France; and Harvard NeuroDiscovery Center (C.S.), Boston, MA.
authors.forename: Clemens
authors.initials: C
authors.lastname: Scherzer
authors.affiliation: From Harvard Medical School (J.P.C., A.P.S., G.A.M., B.B., T.G.-I., C.S., B.T.H., R.A.S., K.A.J.); Massachusetts General Hospital (J.P.C., A.P.S., G.A.M., B.B., T.G.-I., J.D., M.L., A.D.R., B.T.H., R.A.S., K.A.J.), Boston; Martinos Center for Biomedical Imaging (J.P.C., A.P.S., M.L., R.A.S., K.A.J.), Charlestown; Brigham and Women's Hospital (G.A.M., B.B., C.S., R.A.S., K.A.J.), Boston; Biogen (B.B.), Cambridge, MA; Lariboisiere Hospital Memory Center (J.D.), APHP, University Paris 7 Denis Diderot, France; and Harvard NeuroDiscovery Center (C.S.), Boston, MA.
authors.forename: Allyson D
authors.initials: AD
authors.lastname: Roe
authors.affiliation: From Harvard Medical School (J.P.C., A.P.S., G.A.M., B.B., T.G.-I., C.S., B.T.H., R.A.S., K.A.J.); Massachusetts General Hospital (J.P.C., A.P.S., G.A.M., B.B., T.G.-I., J.D., M.L., A.D.R., B.T.H., R.A.S., K.A.J.), Boston; Martinos Center for Biomedical Imaging (J.P.C., A.P.S., M.L., R.A.S., K.A.J.), Charlestown; Brigham and Women's Hospital (G.A.M., B.B., C.S., R.A.S., K.A.J.), Boston; Biogen (B.B.), Cambridge, MA; Lariboisiere Hospital Memory Center (J.D.), APHP, University Paris 7 Denis Diderot, France; and Harvard NeuroDiscovery Center (C.S.), Boston, MA.
authors.forename: Bradley T
authors.initials: BT
authors.lastname: Hyman
authors.affiliation: From Harvard Medical School (J.P.C., A.P.S., G.A.M., B.B., T.G.-I., C.S., B.T.H., R.A.S., K.A.J.); Massachusetts General Hospital (J.P.C., A.P.S., G.A.M., B.B., T.G.-I., J.D., M.L., A.D.R., B.T.H., R.A.S., K.A.J.), Boston; Martinos Center for Biomedical Imaging (J.P.C., A.P.S., M.L., R.A.S., K.A.J.), Charlestown; Brigham and Women's Hospital (G.A.M., B.B., C.S., R.A.S., K.A.J.), Boston; Biogen (B.B.), Cambridge, MA; Lariboisiere Hospital Memory Center (J.D.), APHP, University Paris 7 Denis Diderot, France; and Harvard NeuroDiscovery Center (C.S.), Boston, MA.
authors.forename: Reisa A
authors.initials: RA
authors.lastname: Sperling
authors.affiliation: From Harvard Medical School (J.P.C., A.P.S., G.A.M., B.B., T.G.-I., C.S., B.T.H., R.A.S., K.A.J.); Massachusetts General Hospital (J.P.C., A.P.S., G.A.M., B.B., T.G.-I., J.D., M.L., A.D.R., B.T.H., R.A.S., K.A.J.), Boston; Martinos Center for Biomedical Imaging (J.P.C., A.P.S., M.L., R.A.S., K.A.J.), Charlestown; Brigham and Women's Hospital (G.A.M., B.B., C.S., R.A.S., K.A.J.), Boston; Biogen (B.B.), Cambridge, MA; Lariboisiere Hospital Memory Center (J.D.), APHP, University Paris 7 Denis Diderot, France; and Harvard NeuroDiscovery Center (C.S.), Boston, MA. kajohnson@pet.mgh.harvard.edu.
authors.forename: Keith A
authors.initials: KA
authors.lastname: Johnson
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D016229:Amyloid beta-Peptides / Q000134:cerebrospinal fluid; D053327:Apolipoprotein E4 / Q000235:genetics; D001921:Brain / Q000000981:diagnostic imaging*; D002243:Carbolines / Q000493:pharmacokinetics*; D003430:Cross-Sectional Studies; D005260:Female; D015577:Geriatric Assessment; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008609:Mental Status Schedule; D010766:Phosphorylation; D049268:Positron-Emission Tomography; D013702:Temporal Lobe / Q000000981:diagnostic imaging* / Q000187:drug effects; D016875:tau Proteins / Q000134:cerebrospinal fluid*
chemical_list: D016229:Amyloid beta-Peptides; D053327:Apolipoprotein E4; D002243:Carbolines; D016875:tau Proteins; C000591008:7-(6-fluoropyridin-3-yl)-5H-pyrido(4,3-b)indole