title: Clear-Cell (Reticulated) Transformation of Eyelid Eccrine Sweat Glands.
abstract: A 24-year-old man with a painful, recurrent left upper eyelid nodule underwent an excision. Histopathologic evaluation disclosed a granulomatous process, most likely in response to a ruptured epidermoid cyst. In the vicinity of the nodule were multiple eccrine sweat glands displaying a curious clear-cell appearance in the adlumenal cells, the first example of such a phenomenon in the eyelids. Alcian blue, periodic acid Schiff, and documented staining failed to disclose, respectively, any cytoplasmic mucosubstances, glycogen accumulation, or lipid in the adlumenal secretory cells. Cytokeratin 7 immunostained the adlumenal cells of the eccrine secretory coil, while cytokeratin 5/6 stained the ablumenal myoepithelial and ductular cells. Gross cystic disease fluid protein 15, normally demonstrable in the eccrine secretory cells, was not detectable. Clear-cell transformation should not be confused with syringoma of the lower eyelids, in which glycogen is responsible for the ablumenal clear-cell change.
authors.affiliation: *David G. Cogan Laboratory of Ophthalmic Pathology; and †Ophthalmic Plastic Service, Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts, U.S.A.
authors.forename: Frederick A
authors.initials: FA
authors.lastname: Jakobiec
authors.forename: Anna M
authors.initials: AM
authors.lastname: Stagner
authors.forename: Nahyoung Grace
authors.initials: NG
authors.lastname: Lee
mesh_terms: D001706:Biopsy; D002471:Cell Transformation, Neoplastic / Q000473:pathology*; D004439:Eccrine Glands / Q000473:pathology*; D005142:Eyelid Neoplasms / Q000473:pathology*; D005143:Eyelids / Q000473:pathology*; D006801:Humans; D008297:Male; D013544:Sweat Gland Neoplasms / Q000473:pathology*; D055815:Young Adult