title: Rapid screening of copper intermediates in Cu(i)-catalyzed azide-alkyne cycloaddition using a modified ICP-MS/MS platform.
abstract: Rapid screening of Cu(+)-intermediates by using (63)Cu(+) or (65)Cu(+) ions as catalysts with or without ligand protection in Cu(i)-catalyzed azide-alkyne cycloaddition was realized using an on-line modified ICP-MS/MS platform in this work, while the Cu(+)-intermediates without ligand protection are very active, which are extremely difficult to be observed using other existing techniques. This universal platform was suitable to study the mechanism of organic reactions catalyzed by unstable metal(i) ions as well as to discover new candidates for metal(i) catalysts.
authors.affiliation: Department of Chemistry, Tsinghua University, Beijing 100084, China. xrzhang@mail.tsinghua.edu.cn.
authors.forename: Qian
authors.initials: Q
authors.lastname: He
authors.affiliation: Department of Chemistry, Tsinghua University, Beijing 100084, China. xrzhang@mail.tsinghua.edu.cn.
authors.forename: Zhi
authors.initials: Z
authors.lastname: Xing
authors.affiliation: National Institute of Metrology, Beijing 100029, China.
authors.forename: Chao
authors.initials: C
authors.lastname: Wei
authors.affiliation: National Institute of Metrology, Beijing 100029, China.
authors.forename: Xiang
authors.initials: X
authors.lastname: Fang
authors.affiliation: Department of Chemistry, Tsinghua University, Beijing 100084, China. xrzhang@mail.tsinghua.edu.cn.
authors.forename: Sichun
authors.initials: S
authors.lastname: Zhang
authors.affiliation: Department of Chemistry, Tsinghua University, Beijing 100084, China. xrzhang@mail.tsinghua.edu.cn.
authors.forename: Xinrong
authors.initials: X
authors.lastname: Zhang