title: Operationalizing Frailty in the Atherosclerosis Risk in Communities Study Cohort.
abstract: Factors that may contribute to the development of frailty in late life have not been widely investigated. The Atherosclerosis Risk in Communities (ARIC) Study cohort presents an opportunity to examine relationships of midlife risk factors with frailty in late life. However, we first present findings on the validation of an established frailty phenotype in this predominantly biracial population of older adults.
  
  
  
  Among 6,080 participants, we defined frailty based upon the Cardiovascular Health Study (CHS) criteria incorporating measures of weight loss, exhaustion, slow walking speed, low physical activity, and low grip strength. Criterion and predictive validity of the frailty phenotype were estimated from associations between frailty status and participants' physical and mental health status, physiologic markers, and incident clinical outcomes.
  
  
  
  A total of 393 (6.5%) participants were classified as frail and 50.4% pre-frail, similar to CHS (6.9% frail, 46.6% pre-frail). In age-adjusted analyses, frailty was concurrently associated with depressive symptoms, low self-rated health, low medication adherence, and clinical biomarker levels (ie, cholesterol, hemoglobin A1c, white blood cell count, C-reactive protein, and hemoglobin). During 1-year follow-up, frailty was associated with falls, low physical ability, fatigue, and mortality.
  
  
  
  These findings support the validity of the CHS frailty phenotype in the ARIC Study cohort. Future studies in ARIC may elucidate early-life exposures that contribute to late-life frailty.
authors.affiliation: Department of Epidemiology, University of North Carolina Gillings School of Global Public Health, Chapel Hill.
authors.forename: Anna M
authors.initials: AM
authors.lastname: Kucharska-Newton
authors.affiliation: Department of Epidemiology, University of North Carolina Gillings School of Global Public Health, Chapel Hill.
authors.forename: Priya
authors.initials: P
authors.lastname: Palta
authors.affiliation: Collaborative Studies Coordinating Center, Department of Biostatistics, University of North Carolina Gillings School of Global Public Health, Chapel Hill.
authors.forename: Sheila
authors.initials: S
authors.lastname: Burgard
authors.affiliation: Department of Medicine, University of Mississippi Medical Center, Jackson.
authors.forename: Michael E
authors.initials: ME
authors.lastname: Griswold
authors.affiliation: Department of Epidemiology, University of North Carolina Gillings School of Global Public Health, Chapel Hill.
authors.forename: Jennifer L
authors.initials: JL
authors.lastname: Lund
authors.affiliation: Division of Epidemiology and Community Health, University of Minnesota, Minneapolis.
authors.forename: Benjamin D
authors.initials: BD
authors.lastname: Capistrant
authors.affiliation: Division of Gerontology and Geriatric Medicine, Department of Medicine, Wake Forest University, Winston-Salem, North Carolina.
authors.forename: Stephen B
authors.initials: SB
authors.lastname: Kritchevsky
authors.affiliation: Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland.
authors.forename: Karen
authors.initials: K
authors.lastname: Bandeen-Roche
authors.affiliation: Department of Medicine, University of Mississippi Medical Center, Jackson.
authors.forename: B Gwen
authors.initials: BG
authors.lastname: Windham
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D050197:Atherosclerosis / Q000453:epidemiology* / Q000209:etiology* / Q000235:genetics; D015331:Cohort Studies; D005260:Female; D016330:Frail Elderly; D015577:Geriatric Assessment; D006801:Humans; D008297:Male; D010641:Phenotype; D018570:Risk Assessment
keywords: Cohort study; Epidemiology; Frailty