title: Is the prognosis the same for periprosthetic joint infections due to Staphylococcus aureus versus coagulase-negative staphylococci? A retrospective study of 101 patients with 2-year minimum follow-up.
abstract: BACKGROUND
  Staphylococcus aureus (SA) and Coagulase-negative staphylococci (CoNS) are often responsible for infections of total hip arthroplasty (THA) and total knee arthroplasty (TKA). One of the main differences between these two microorganisms is their virulence, with SA presumed to be more virulent; however, few studies have specifically investigated the impact of this virulence. This inspired us to carry out a retrospective study to evaluate whether the healing rate differed between SA and CoNS infections.
  
  
  OBJECTIVE
  We hypothesised that the healing rate is lower for SA prosthetic joint infections.
  
  
  METHODS
  This was a retrospective study of 101 consecutive Staphylococcus infection cases that occurred between 2007 and 2011. There were 56 men and 45 women with an average age of 69 years (range 23-95). The infection was associated with TKA in 38 cases and THA in 63 cases. Thirty-two percent of patients had one or more comorbidities with infectious potential. In our cohort, there were 32 SA infections (31.7 %) and 69 CoNS infections (68.3 %) with 58 of the infections being methicillin-resistant (15 SA and 43 CoNS); there were 27 polymicrobial infections (26.7 %).
  
  
  RESULTS
  With a minimum 24-month follow-up after the end of antibiotic treatment, the healing rate was 70.3 % overall (71 patients). The healing rate was 75 % in the SA group (24 patients) versus 68.1 % (47 patients) in the CoNS group (P = 0.42).
  
  
  CONCLUSIONS
  Our hypothesis was not confirmed: the healing rate of SA prosthetic joint infections was not lower than that of CoNS infections.
  
  
  METHODS
  III, retrospective case-control study.
authors.affiliation: Département de Chirurgie Orthopédique et Traumatologie, Hôpital Pierre Paul Riquet place du Dr Baylac, TSA 40031, 31059, Toulouse, France. murgier.jerome@hotmail.fr.
authors.forename: J
authors.initials: J
authors.lastname: Murgier
authors.affiliation: Département de Chirurgie Orthopédique et Traumatologie, Hôpital Pierre Paul Riquet place du Dr Baylac, TSA 40031, 31059, Toulouse, France.
authors.forename: J-M
authors.initials: JM
authors.lastname: Laffosse
authors.affiliation: Département de Chirurgie Orthopédique et Traumatologie, Hôpital Pierre Paul Riquet place du Dr Baylac, TSA 40031, 31059, Toulouse, France.
authors.forename: J
authors.initials: J
authors.lastname: Cailliez
authors.affiliation: Département de Chirurgie Orthopédique et Traumatologie, Hôpital Pierre Paul Riquet place du Dr Baylac, TSA 40031, 31059, Toulouse, France.
authors.forename: E
authors.initials: E
authors.lastname: Cavaignac
authors.affiliation: Département de Chirurgie Orthopédique et Traumatologie, Hôpital Pierre Paul Riquet place du Dr Baylac, TSA 40031, 31059, Toulouse, France.
authors.forename: P
authors.initials: P
authors.lastname: Murgier
authors.affiliation: Département de Chirurgie Orthopédique et Traumatologie, Hôpital Pierre Paul Riquet place du Dr Baylac, TSA 40031, 31059, Toulouse, France.
authors.forename: X
authors.initials: X
authors.lastname: Bayle-Iniguez
authors.affiliation: Département de Chirurgie Orthopédique et Traumatologie, Hôpital Pierre Paul Riquet place du Dr Baylac, TSA 40031, 31059, Toulouse, France.
authors.forename: P
authors.initials: P
authors.lastname: Chiron
authors.affiliation: Département de Chirurgie Orthopédique et Traumatologie, Hôpital Pierre Paul Riquet place du Dr Baylac, TSA 40031, 31059, Toulouse, France.
authors.forename: P
authors.initials: P
authors.lastname: Bonnevialle
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D019644:Arthroplasty, Replacement, Hip; D019645:Arthroplasty, Replacement, Knee; D016022:Case-Control Studies; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007595:Joint Prosthesis / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D016459:Prosthesis-Related Infections / Q000175:diagnosis / Q000188:drug therapy* / Q000382:microbiology*; D012189:Retrospective Studies; D013203:Staphylococcal Infections / Q000175:diagnosis / Q000188:drug therapy* / Q000382:microbiology*; D013211:Staphylococcus aureus / Q000472:pathogenicity*; D014945:Wound Healing
chemical_list: D000900:Anti-Bacterial Agents
keywords: Periprosthetic joint infection; Staphylococcus spp.; Total hip arthroplasty; Total knee arthroplasty