title: Mitochondrial Chemical Biology: New Probes Elucidate the Secrets of the Powerhouse of the Cell.
abstract: Mitochondria are energy-producing organelles with essential functions in cell biology, and mitochondrial dysfunction is linked to a wide range of human diseases. Efforts to better understand mitochondrial biology have been limited by the lack of tools for manipulating and detecting processes occurring within the organelle. Here, we highlight recent significant advances in mitochondrial chemical biology that have produced new tools and techniques for studying mitochondria. Specifically, we focus on the development of chemical tools to perturb mitochondrial biochemistry, probes allowing precise measurement of mitochondrial function, and new techniques for high-throughput characterization of the mitochondrial proteome. Taken together, these advances in chemical biology will enable exciting new directions in mitochondrial research.
authors.affiliation: Department of Biochemistry, Faculty of Medicine, University of Toronto, Toronto, ON M5S 1A8, Canada.
authors.forename: Simon
authors.initials: S
authors.lastname: Wisnovsky
authors.affiliation: Department of Biochemistry, Faculty of Medicine, University of Toronto, Toronto, ON M5S 1A8, Canada.
authors.forename: Eric K
authors.initials: EK
authors.lastname: Lei
authors.affiliation: Department of Chemistry, Faculty of Arts and Science, University of Toronto, Toronto, ON M5S 3H6, Canada.
authors.forename: Sae Rin
authors.initials: SR
authors.lastname: Jean
authors.affiliation: Department of Biochemistry, Faculty of Medicine, University of Toronto, Toronto, ON M5S 1A8, Canada; Department of Chemistry, Faculty of Arts and Science, University of Toronto, Toronto, ON M5S 3H6, Canada; Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, ON M5S 3M2, Canada. Electronic address: shana.kelley@utoronto.ca.
authors.forename: Shana O
authors.initials: SO
authors.lastname: Kelley
mesh_terms: D000818:Animals; D004272:DNA, Mitochondrial / Q000378:metabolism; D006801:Humans; D008928:Mitochondria / Q000187:drug effects / Q000378:metabolism* / Q000502:physiology; D028361:Mitochondrial Diseases / Q000378:metabolism*
chemical_list: D004272:DNA, Mitochondrial