title: Broadening Horizons: New Antibodies Against Influenza.
abstract: Seasonal influenza vaccine formulation efforts struggle to keep up with viral antigenic variation. Two studies now report engineered or naturally occurring human antibodies targeting the influenza hemagglutinin (HA) stem, with exceptional neutralizing breadth (Joyce et al., 2016; Kallewaard et al., 2016). Antibodies with similar structural features are elicited in multiple subjects, suggesting that modified vaccine regimens could provide broad protection.
authors.affiliation: Department of Pathology, Stanford University, CA 94305, USA.
authors.forename: Katherine J L
authors.initials: KJL
authors.lastname: Jackson
authors.affiliation: Department of Pathology, Stanford University, CA 94305, USA. Electronic address: sboyd1@stanford.edu.
authors.forename: Scott D
authors.initials: SD
authors.lastname: Boyd
mesh_terms: D057134:Antibodies, Neutralizing / Q000276:immunology; D000914:Antibodies, Viral / Q000276:immunology; D019267:Hemagglutinin Glycoproteins, Influenza Virus / Q000276:immunology*; D006801:Humans; D007252:Influenza Vaccines / Q000276:immunology; D007251:Influenza, Human / Q000276:immunology*
chemical_list: D057134:Antibodies, Neutralizing; D000914:Antibodies, Viral; D019267:Hemagglutinin Glycoproteins, Influenza Virus; D007252:Influenza Vaccines