title: Cerebral circulation in aging.
abstract: Cerebral circulation is known to be protected by the regulatory function against the hypoperfusion that will affect the cognitive function as a result of brain ischemia and energy failure. The regulatory function includes cerebrovascular autoregulation, chemical control, metabolic control, and neurogenic control, and those compensatory mechanisms can be influenced by hypertension, atherosclerosis, cardiac diseases, cerebrovascular diseases and aging. On the other hand, large and/or small infarction, intracranial hemorrhage, subarachnoid hemorrhage, atherosclerosis, amylod angiopathy are also more directly associated with cognitive decline not only in those with vascular cognitive impairment or vascular dementia but also those with Alzheimer's disease.
authors.affiliation: Department of Neurology, Clinical Research Institute, Yokohama General Hospital, Yokohama, Japan. Electronic address: nagata@yokoso.or.jp.
authors.forename: Ken
authors.initials: K
authors.lastname: Nagata
authors.affiliation: Department of Neurology, Clinical Research Institute, Yokohama General Hospital, Yokohama, Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Yamazaki
authors.affiliation: Department of Neurology, Clinical Research Institute, Yokohama General Hospital, Yokohama, Japan.
authors.forename: Daiki
authors.initials: D
authors.lastname: Takano
authors.affiliation: Department of Neurology and Gerontology, Iwate Medical University, Morioka, Japan.
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Maeda
authors.affiliation: Department of Neurology, Research Institute for Brain and Blood Vessels, Akita, Japan.
authors.forename: Yumi
authors.initials: Y
authors.lastname: Fujimaki
authors.affiliation: Department of Neurology, Research Institute for Brain and Blood Vessels, Akita, Japan.
authors.forename: Taizen
authors.initials: T
authors.lastname: Nakase
authors.affiliation: Department of Neurology, Noshiro Yamamoto Medical Association Hospital, Noshiro, Japan.
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Sato
mesh_terms: D000375:Aging / Q000502:physiology*; D000818:Animals; D001812:Blood-Brain Barrier; D001921:Brain / Q000098:blood supply* / Q000254:growth & development*; D002560:Cerebrovascular Circulation / Q000502:physiology*; D004734:Energy Metabolism / Q000502:physiology; D006706:Homeostasis / Q000502:physiology; D006801:Humans