title: Two-year changes in circulating adiponectin, ectopic fat distribution and body composition in response to weight-loss diets: the POUNDS Lost Trial.
abstract: Adiponectin has a pivotal role in linking fat distribution with cardiometabolic disorders. We investigated the associations of long-term changes in circulating adiponectin with body composition and fat distribution at different abdominal depots in response to weight-loss dietary interventions, as well as the modification effect of sex.
  
  
  
  In the 2-year Preventing Overweight Using Novel Dietary Strategies (POUNDS Lost) Trial, 811 overweight or obese adults were randomly assigned to one of four diets varying in macronutrient intakes. Circulating concentrations of adiponectin were repeatedly measured at baseline, 6 months and 2 years. Body composition and fat distribution were repeatedly measured by dual-energy X-ray absorptiometry scan (n=424) and computed tomography (n=195).
  
  
  
  Over the 2-year intervention, after adjustment for age, sex, ethnicity, follow-up time, diet group, baseline body mass index and baseline level of respective outcome trait, increase of adiponectin was significantly associated with reduction of total fat mass (FM), total fat-free mass (FFM), whole body total percentage of fat mass (FM%), percentage of trunk fat (TF%), total adipose tissue (TAT), and adipose tissue mass at different depots including visceral (VAT), deep subcutaneous (DSAT) and superficial subcutaneous (SSAT; P<0.03 for each). The relations with FM, FM%, TF%, VAT and DSAT were significantly modified by sex (P for interaction=0.02, 0.005 and <0.001, 0.002, 0.03, respectively) with greater reductions associated with increase of adiponectin in men than in women.
  
  
  
  Long-term changes in circulating adiponectin were differentially associated with improvement of body composition and abdominal fat distribution in men and women.
authors.affiliation: Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
authors.forename: W
authors.initials: W
authors.lastname: Ma
authors.affiliation: Department of Epidemiology, School of Public Health and Tropical Medicine, Tulane University, New Orleans, LA, USA.
authors.forename: T
authors.initials: T
authors.lastname: Huang
authors.affiliation: Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
authors.forename: M
authors.initials: M
authors.lastname: Wang
authors.affiliation: Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
authors.forename: Y
authors.initials: Y
authors.lastname: Zheng
authors.affiliation: Department of Epidemiology, School of Public Health and Tropical Medicine, Tulane University, New Orleans, LA, USA.
authors.forename: T
authors.initials: T
authors.lastname: Wang
authors.affiliation: Department of Epidemiology, School of Public Health and Tropical Medicine, Tulane University, New Orleans, LA, USA.
authors.forename: Y
authors.initials: Y
authors.lastname: Heianza
authors.affiliation: Department of Epidemiology, School of Public Health and Tropical Medicine, Tulane University, New Orleans, LA, USA.
authors.forename: D
authors.initials: D
authors.lastname: Sun
authors.affiliation: Translational Research Institute for Metabolism and Diabetes, Florida Hospital and Sanford Burnham Institute, Orlando, FL, USA.
authors.forename: S R
authors.initials: SR
authors.lastname: Smith
authors.affiliation: Pennington Biomedical Research Center of the Louisiana State University System, Baton Rouge, LA, USA.
authors.forename: G A
authors.initials: GA
authors.lastname: Bray
authors.affiliation: Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
authors.forename: F M
authors.initials: FM
authors.lastname: Sacks
authors.affiliation: Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.|Department of Epidemiology, School of Public Health and Tropical Medicine, Tulane University, New Orleans, LA, USA.|Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA.|Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
authors.forename: L
authors.initials: L
authors.lastname: Qi
mesh_terms: D050153:Abdominal Fat / Q000378:metabolism*; D052242:Adiponectin / Q000097:blood*; D000328:Adult; D001823:Body Composition; D050218:Body Fat Distribution; D015992:Body Mass Index; D003430:Cross-Sectional Studies; D004038:Diet, Reducing / Q000379:methods; D005260:Female; D006801:Humans; D008297:Male; D009765:Obesity / Q000150:complications / Q000178:diet therapy / Q000378:metabolism*; D012307:Risk Factors; D013997:Time Factors; D016896:Treatment Outcome; D014481:United States; D015431:Weight Loss / Q000502:physiology*
chemical_list: C499918:ADIPOQ protein, human; D052242:Adiponectin