title: Role of Nuclear Factor Kappa B (NF-κB) in Growth Plate Chondrogenesis.
abstract: Abstract Nuclear Factor kappa B (NF-κB) is a group of seven transcription factors. Upon activation by a variety of stimuli, NF-κB translocates to the nucleus and modulates the expression of target genes involved in cell growth, survival, and death. Previous evidence indicates that NF-κB regulates bone growth and development. We have shown that the NF-κB p65 is expressed in the growth plate and facilitates longitudinal bone growth by inducing chondrocyte proliferation and differentiation and by preventing apoptosis. Furthermore, we have demonstrated in rodents that NF-κB expressed in growth plate chondrocytes mediates the promoting effects of GH and IGF-1 on longitudinal bone growth and growth plate chondrogenesis. Lastly, functional studies carried out in two children with growth failure and GH insensitivity, and affected by two different mutations impairing NF-κB activation, indicate that NF-κB also mediates the growth-promoting effects of GH in humans.
authors.forename: Francesco
authors.initials: F
authors.lastname: De Luca
mesh_terms: D001846:Bone Development / Q000502:physiology; D020219:Chondrogenesis / Q000502:physiology*; D013006:Growth Hormone / Q000502:physiology; D006132:Growth Plate / Q000254:growth & development*; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000502:physiology; D016328:NF-kappa B / Q000502:physiology*
chemical_list: D016328:NF-kappa B; D007334:Insulin-Like Growth Factor I; D013006:Growth Hormone