title: Upregulation of miR-522 is associated with poor outcome of hepatocellular carcinoma.
abstract: The aim of our study was to explore the clinicopathologic and prognostic significance of miR-522 expression in human hepatocellular carcinoma (HCC).
  
  
  
  The expression of miR-522 in 161 HCC tissues and adjacent non-tumor tissues was examined using quantitative real-time-PCR. The association of miR-522 expression with clinicopathological features and the prognosis of HCC patients were also analyzed. The overall survival (OS) was analyzed by log-rank test. Cox regression models were fitted to analyze the effect of prognostic factors on OS.
  
  
  
  The relative level of miR-522 was significantly higher in HCC tissues compared to the adjacent normal liver tissues. In addition, miR-522 upregulation more frequently occurred in HCC specimens with lymph node metastasis (p = 0.000), and tumor grade (p = 0.002). Moreover, the level of miR-522 expression was markedly correlated with the HCC patients' overall survival (p < 0.000). In the Cox proportional hazard model, the results showed that miR-522 overexpression was an independent prognostic factor for OS CONCLUSIONS: Overexpression of miR-522 functions as an unfavorable prognostic biomarker in HCC patients.
authors.affiliation: Department of General Surgery, Department of Endocrinology; The Third People's Hospital of Yancheng City, Jiangsu Province, China. pqsh333@yeah.net.
authors.forename: Y-H
authors.initials: YH
authors.lastname: Shi
authors.forename: B-B
authors.initials: BB
authors.lastname: Qi
authors.forename: X-B
authors.initials: XB
authors.lastname: Liu
authors.forename: H-M
authors.initials: HM
authors.lastname: Ding
mesh_terms: D006528:Carcinoma, Hepatocellular / Q000235:genetics* / Q000473:pathology; D015972:Gene Expression Regulation, Neoplastic / Q000502:physiology; D006801:Humans; D053208:Kaplan-Meier Estimate; D008113:Liver Neoplasms / Q000235:genetics* / Q000473:pathology; D035683:MicroRNAs / Q000096:biosynthesis / Q000235:genetics; D015854:Up-Regulation
chemical_list: C560599:MIRN522 microRNA, human; D035683:MicroRNAs