title: An updated meta-analysis of 37 case-control studies on the association between NFKB1 -94ins/del ATTG promoter polymorphism and cancer susceptibility.
abstract: As a cell survival signal, nuclear factor-kappa B (NFKB) is associated with the pathogenesis of numerous malignancies. According to several studies, NFKB1 -94ins/del ATTG promoter polymorphism is associated with the risk of different malignancies, but the results were not consistent. Therefore, we performed an updated meta-analysis based on 37 case-control studies from 33 articles (16,271 cases and 22,781 controls) to clarify the relationship. The odds ratio (OR) and 95% confidence interval (CI) were used to determine the strength of the association. We found that the NFKB1 -94ins/del ATTG promoter polymorphism was significantly associated with increased susceptibility to cancer in the recessive (II vs. ID+DD, OR = 1.140, 95% CI = 1.029-1.263, p =0.012), homozygote (II vs. DD, OR = 1.259, 95% CI = 1.068-1.485, p =0.006), and allele (I vs. D, OR = 1.109, 95% CI = 1.025-1.199, p =0.010) genetic models. The subgroup analysis for ethnicity found that the NFKB1 -94ins/del ATTG promoter polymorphism was significantly associated with an increased susceptibility to cancer in Asians and with a decreased susceptibility in Caucasians. The stratified analyses revealed significant associations between the polymorphism and increased susceptibility to ovarian cancer, oral squamous cell carcinoma, and nasopharyngeal carcinoma.
authors.affiliation: Department of Thoracic Oncology, West China Hospital/West China School of Medicine, Sichuan University, Chengdu, China.
authors.forename: Yi-Qiao
authors.initials: YQ
authors.lastname: Luo
authors.affiliation: Department of Orthopaedics, West China School of Medicine, West China Hospital, Sichuan University, Chengdu, China.
authors.forename: Duan
authors.initials: D
authors.lastname: Wang
authors.affiliation: Sichuan Mianyang 404 Hospital, Mianyang, China.
authors.forename: Teng
authors.initials: T
authors.lastname: Gong
authors.affiliation: Department of Thoracic Oncology, West China Hospital, Sichuan University, Chengdu, China.
authors.forename: Jiang
authors.initials: J
authors.lastname: Zhu
mesh_terms: D000483:Alleles; D044466:Asian People; D002294:Carcinoma, Squamous Cell / Q000175:diagnosis / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D020022:Genetic Predisposition to Disease; D006720:Homozygote; D006801:Humans; D009062:Mouth Neoplasms / Q000175:diagnosis / Q000235:genetics*; D052002:NF-kappa B p50 Subunit / Q000235:genetics*; D009303:Nasopharyngeal Neoplasms / Q000175:diagnosis / Q000235:genetics*; D016017:Odds Ratio; D010051:Ovarian Neoplasms / Q000175:diagnosis / Q000235:genetics*; D011110:Polymorphism, Genetic; D011401:Promoter Regions, Genetic; D016896:Treatment Outcome; D044465:White People
chemical_list: D052002:NF-kappa B p50 Subunit; C489548:NFKB1 protein, human
keywords: NFKB1; cancer; meta-analysis; polymorphism