title: Meta-analysis of the relationship between microRNA-499 rs3746444 polymorphism and hepatocellular carcinoma risk in Asians.
abstract: OBJECTIVE
  Numerous studies have reported the role of microRNA-499 rs3746444 polymorphism with hepatocellular carcinoma. (HCC) risk in Asians, but the specific association is still controversial.
  
  
  METHODS
  To derive a more precise estimation of the relationship, a meta-analysis was performed. An electronic search of PubMed database was conducted to select relevant studies. Odds ratios. (ORs) with 95% confidence intervals. (CIs) were estimated to assess the relationship between microRNA-499 rs3746444 polymorphism and HCC risk in Asians.
  
  
  RESULTS
  Eight relevant studies including 2196 cases and 2701 controls were included in this meta-analysis. When all the eligible studies were pooled into this meta-analysis, no significant association of HCC risk with microRNA-499 rs3746444 polymorphism was found in Asians (TT vs. CC: OR = 1.00 95% CI = 0.54-1.83; TT vs. TC: OR = 0.89, 95% CI = 0.66-1.20; dominant model: OR = 1.13, 95% CI = 0.81-1.58; recessive model: OR = 0.99, 95% CI = 0.56-1.76).
  
  
  CONCLUSIONS
  This meta-analysis suggests that the microRNA-499 rs3746444 polymorphism is not contributed to the risk of HCC in Asians. However, more studies should be performed in the future to confirm this association.
authors.affiliation: Department of Radiology, Anhui Provincial Hospital Affiliated to Anhui Medical University, Hefei, China.
authors.forename: Weiyu
authors.initials: W
authors.lastname: Wang
authors.affiliation: Department of Radiology, Anhui Provincial Hospital Affiliated to Anhui Medical University, Hefei, China.
authors.forename: Hanlin
authors.initials: H
authors.lastname: Qin
authors.affiliation: Department of Radiology, Anhui Provincial Hospital Affiliated to Anhui Medical University, Hefei, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Zhou
authors.affiliation: Department of Hepatic Surgery, Anhui Provincial Hospital Affiliated to Anhui Medical University, Hefei, China.
authors.forename: Jinliang
authors.initials: J
authors.lastname: Ma
mesh_terms: D000483:Alleles; D044466:Asian People / Q000235:genetics*; D006528:Carcinoma, Hepatocellular / Q000235:genetics*; D016022:Case-Control Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008113:Liver Neoplasms / Q000235:genetics*; D035683:MicroRNAs; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D017594:Publication Bias; D012307:Risk Factors
chemical_list: C548683:MIRN499 microRNA, human; D035683:MicroRNAs