title: Enantioselective Organocatalyzed Transformations of β-Ketoesters.
abstract: The β-ketoester structural motif continues to intrigue chemists with its electrophilic and nucleophilic sites. Proven to be a valuable tool within organic synthesis, natural product, and medicinal chemistry, reports on chiral β-ketoester molecular skeletons display a steady increase. With the reignition of organocatalysis in the past decade, asymmetric methods available for the synthesis of this structural unit has significantly expanded, making it one of the most exploited substrates for organocatalytic transformations. This review provides comprehensive information on the plethora of organocatalysts used in stereoselective organocatalyzed construction of β-ketoester-containing compounds.
authors.affiliation: Catalysis and Peptide Research Unit, University of KwaZulu Natal , Durban, 4001, South Africa.
authors.forename: Thavendran
authors.initials: T
authors.lastname: Govender
authors.affiliation: Catalysis and Peptide Research Unit, University of KwaZulu Natal , Durban, 4001, South Africa.|P. I. Arvidsson, Science for Life Laboratory, Drug Discovery and Development Platform and Division of Translational Medicine and Chemical Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet SE-171 77 Stockholm, Sweden.
authors.forename: Per I
authors.initials: PI
authors.lastname: Arvidsson
authors.affiliation: Catalysis and Peptide Research Unit, University of KwaZulu Natal , Durban, 4001, South Africa.
authors.forename: Glenn E M
authors.initials: GE
authors.lastname: Maguire
authors.affiliation: Catalysis and Peptide Research Unit, University of KwaZulu Natal , Durban, 4001, South Africa.
authors.forename: Hendrik G
authors.initials: HG
authors.lastname: Kruger
authors.affiliation: Catalysis and Peptide Research Unit, University of KwaZulu Natal , Durban, 4001, South Africa.
authors.forename: Tricia
authors.initials: T
authors.lastname: Naicker
mesh_terms: D000447:Aldehydes / Q000737:chemistry; D002384:Catalysis; D060326:Chemistry Techniques, Synthetic; D004952:Esters / Q000737:chemistry*; D006860:Hydrogen Bonding; D007097:Imines / Q000737:chemistry; D007659:Ketones / Q000737:chemistry*; D008301:Maleimides / Q000737:chemistry; D009574:Nitro Compounds / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D000447:Aldehydes; D004952:Esters; D007097:Imines; D007659:Ketones; D008301:Maleimides; D009574:Nitro Compounds