title: [Surgical removal of Salzmann's nodules using intraoperative mitomycin C].
abstract: Salzmann's nodules comprise a heterogeneous group of greyish superficial corneal opacities. A substantial percentage is most likely caused by dystrophies. This could explain the recurrences after surgical removal. The Eye Center of the University Hospital Freiburg has been using mitomycin C intraoperatively during surgical removal of Salzmann's nodules since 2007 to prevent recurrences. We recently performed an uncontrolled prospective trial to evaluate this approach and also reviewed the literature. Worldwide, a total of 38 eyes have been treated with mitomycin C during surgery for Salzmann's nodules. No recurrences have been reported so far with follow-up exceeding at least 2 years in almost all eyes. No severe side effects have been observed to date. We therefore think that mitomycin C during surgery for Salzmann's nodules is advisable despite the lack of evidence from a randomized clinical trial. However, all patients must consent to the off label use of mitomycin C.
authors.affiliation: Klinik für Augenheilkunde, Universitätsklinikum Freiburg, Medizinische Fakultät, Albert-Ludwigs-Universität Freiburg, Killianstr. 5, 79106, Freiburg, Deutschland. daniel.boehringer@uniklinik-freiburg.de.
authors.forename: D
authors.initials: D
authors.lastname: Böhringer
authors.affiliation: Klinik für Augenheilkunde, Universitätsklinikum Freiburg, Medizinische Fakultät, Albert-Ludwigs-Universität Freiburg, Killianstr. 5, 79106, Freiburg, Deutschland.
authors.forename: D
authors.initials: D
authors.lastname: Widmer
authors.affiliation: Klinik für Augenheilkunde, Universitätsklinikum Freiburg, Medizinische Fakultät, Albert-Ludwigs-Universität Freiburg, Killianstr. 5, 79106, Freiburg, Deutschland.
authors.forename: P
authors.initials: P
authors.lastname: Eberwein
authors.affiliation: Klinik für Augenheilkunde, Universitätsklinikum Freiburg, Medizinische Fakultät, Albert-Ludwigs-Universität Freiburg, Killianstr. 5, 79106, Freiburg, Deutschland.
authors.forename: P
authors.initials: P
authors.lastname: Maier
authors.affiliation: Klinik für Augenheilkunde, Universitätsklinikum Freiburg, Medizinische Fakultät, Albert-Ludwigs-Universität Freiburg, Killianstr. 5, 79106, Freiburg, Deutschland.
authors.forename: T
authors.initials: T
authors.lastname: Reinhard
mesh_terms: D000328:Adult; D000368:Aged; D003131:Combined Modality Therapy / Q000379:methods; D003318:Corneal Opacity / Q000000981:diagnostic imaging / Q000473:pathology* / Q000628:therapy*; D005500:Follow-Up Studies; D006801:Humans; D008137:Longitudinal Studies; D008875:Middle Aged; D016685:Mitomycin / Q000008:administration & dosage*; D056687:Off-Label Use; D013508:Ophthalmologic Surgical Procedures / Q000379:methods*; D010865:Pilot Projects; D012008:Recurrence; D016896:Treatment Outcome
chemical_list: D016685:Mitomycin
keywords: Corneal degeneration; Dystrophy; Off label use; Prevention; Recurrence