title: Significance of kinase activity in the dynamic invadosome.
abstract: Invadosomes are actin rich protrusive structures that facilitate invasive migration in multiple cell types. Comprised of invadopodia and podosomes, these highly dynamic structures adhere to and degrade the extracellular matrix, and are also thought to play a role in mechanosensing. Many extracellular signals have been implicated in invadosome stimulation, activating complex signalling cascades to drive the formation, activity and turnover of invadosomes. While the structural components of invadosomes have been well studied, the regulation of invadosome dynamics is still poorly understood. Protein kinases are essential to this regulation, affecting all stages of invadosome dynamics and allowing tight spatiotemporal control of their activity. Invadosome organisation and function have been linked to pathophysiological states such as cancer invasion and metastasis; therapeutic targeting of invadosome regulatory components is thus warranted. In this review, we discuss the involvement of kinase signalling in every stage of the invadosome life cycle and evaluate its significance.
authors.affiliation: Randall Division of Cell & Molecular Biophysics, King's College London, Guy's Campus, London SE1 1UL, UK.
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Foxall
authors.affiliation: Cancer Division, King's College London, Guy's Campus, London SE1 1UL, UK.
authors.forename: Aikaterini
authors.initials: A
authors.lastname: Pipili
authors.affiliation: Randall Division of Cell & Molecular Biophysics, King's College London, Guy's Campus, London SE1 1UL, UK. Electronic address: gareth.jones@kcl.ac.uk.
authors.forename: Gareth E
authors.initials: GE
authors.lastname: Jones
authors.affiliation: Cancer Division, King's College London, Guy's Campus, London SE1 1UL, UK. Electronic address: claire.wells@kcl.ac.uk.
authors.forename: Claire M
authors.initials: CM
authors.lastname: Wells
mesh_terms: D000818:Animals; D002448:Cell Adhesion; D005109:Extracellular Matrix / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D009361:Neoplasm Invasiveness; D009363:Neoplasm Proteins / Q000378:metabolism*; D009369:Neoplasms / Q000378:metabolism* / Q000473:pathology; D000069261:Podosomes / Q000378:metabolism* / Q000473:pathology; D011494:Protein Kinases / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D009363:Neoplasm Proteins; D011494:Protein Kinases
keywords: Actin; Invadopodia; Kinases; Podosomes; Src; Tyrosine phosphorylation