title: Cost-effectiveness of a herpes zoster vaccination program among the French elderly people.
abstract: A vaccine against herpes zoster (HZ) and its complications has already proven safe and effective against infection and pain and against the related deterioration of quality of life in the elderly. In order to inform the vaccination decision-making process regarding inclusion of this vaccine in the French immunization schedule, we assessed the cost-effectiveness of several vaccination scenarios, compared to no vaccination. We chose to use a previously published Markov model. Starting vaccination in elderly individuals aged 65, 70 and 75 y old appears more cost-effective than vaccination for those aged 60 y old, with a cost-effectiveness ratio between 30,000 and 35,000 euros per quality-adjusted-life year (QALY) gained for the first 3 age groups versus 54,500 €; for the latter group. These results largely contributed to the recommendation to include the HZ vaccination in the French immunization schedule for people aged between 65 and 74 y old in France.
authors.affiliation: a Santé Publique France, French National Public Health Agency , Saint-Maurice , France.
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Belchior
authors.affiliation: a Santé Publique France, French National Public Health Agency , Saint-Maurice , France.
authors.forename: Daniel
authors.initials: D
authors.lastname: Lévy-Bruhl
authors.affiliation: a Santé Publique France, French National Public Health Agency , Saint-Maurice , France.
authors.forename: Yann
authors.initials: Y
authors.lastname: Le Strat
authors.affiliation: a Santé Publique France, French National Public Health Agency , Saint-Maurice , France.
authors.forename: Magid
authors.initials: M
authors.lastname: Herida
mesh_terms: D000368:Aged; D003362:Cost-Benefit Analysis; D005260:Female; D005602:France / Q000453:epidemiology; D006562:Herpes Zoster / Q000191:economics* / Q000453:epidemiology / Q000517:prevention & control*; D053061:Herpes Zoster Vaccine / Q000008:administration & dosage* / Q000191:economics*; D006801:Humans; D017589:Immunization Programs / Q000191:economics*; D008297:Male; D008875:Middle Aged
chemical_list: D053061:Herpes Zoster Vaccine
keywords: Herpes zoster; cost-effectiveness; epidemiology; infectious disease; mathematical modeling; postherpetic neuralgia; vaccination; vaccine; vaccinology; viral