title: Effects of a dietary strawberry powder on parameters of vascular health in adolescent males.
abstract: Previous studies have shown that the intake of freeze-dried strawberry powder (FDSP) improves select markers of cardiovascular health in adults with cardiovascular risk factors; however, whether these improvements can be observed in at-risk adolescents is unknown. A randomised, double-blind, cross-over study enrolled twenty-five overweight or obese males, aged 14-18 years, to consume 50 g of a FDSP or a control powder, daily for 1 week. Before and after each test period, measures of microvascular function, plasma nitrate/nitrite, platelet reactivity and blood lipids were collected at baseline and acutely 1 h after FDSP intake. Acute plasma nitrate/nitrite levels increased 1 h after consuming the FDSP during Study Visit 1 before daily FDSP intake (P<0·001) and during Study Visit 2 after 1 week of FDSP intake (P<0·001) compared with control powder intake. As a group, fasting nitrate/nitrite levels did not significantly change after 1 week of control or FDSP intake. However, for those individuals where fasting nitrate levels increased after short-term FDSP intake compared with controls, an increase in reactive hyperaemia index (RHI) was observed (P=0·014), whereas RHI was unchanged in those individuals who did not have a significant increase in nitrate (P=0·396). Taken together, these data support the concept that strawberries can provide vascular health benefits to heavier adolescent males.
authors.affiliation: 1Department of Nutrition,University of California, Davis,One Shields Avenue,Davis,CA 95616,USA.
authors.forename: Dragana
authors.initials: D
authors.lastname: Djurica
authors.affiliation: 1Department of Nutrition,University of California, Davis,One Shields Avenue,Davis,CA 95616,USA.
authors.forename: Roberta R
authors.initials: RR
authors.lastname: Holt
authors.affiliation: 1Department of Nutrition,University of California, Davis,One Shields Avenue,Davis,CA 95616,USA.
authors.forename: Jingyan
authors.initials: J
authors.lastname: Ren
authors.affiliation: 2Department of Urology,University of California Davis Medical Center;4860 Y Street,Suite 2200 Sacramento,CA 95817,USA.
authors.forename: Alan W
authors.initials: AW
authors.lastname: Shindel
authors.affiliation: 1Department of Nutrition,University of California, Davis,One Shields Avenue,Davis,CA 95616,USA.
authors.forename: Robert M
authors.initials: RM
authors.lastname: Hackman
authors.affiliation: 1Department of Nutrition,University of California, Davis,One Shields Avenue,Davis,CA 95616,USA.
authors.forename: Carl L
authors.initials: CL
authors.lastname: Keen
mesh_terms: D000293:Adolescent; D001628:Beverages; D015415:Biomarkers / Q000097:blood; D002318:Cardiovascular Diseases / Q000209:etiology / Q000517:prevention & control*; D018592:Cross-Over Studies; D004032:Diet; D004311:Double-Blind Method; D005215:Fasting / Q000097:blood; D031985:Fragaria; D005612:Freeze Drying; D006801:Humans; D006940:Hyperemia; D008055:Lipids / Q000097:blood; D008297:Male; D009566:Nitrates / Q000097:blood; D009573:Nitrites / Q000097:blood; D050177:Overweight / Q000097:blood / Q000150:complications / Q000178:diet therapy*; D063766:Pediatric Obesity / Q000097:blood / Q000150:complications / Q000178:diet therapy*; D015539:Platelet Activation; D019518:Postprandial Period; D011208:Powders; D012307:Risk Factors
chemical_list: D015415:Biomarkers; D008055:Lipids; D009566:Nitrates; D009573:Nitrites; D011208:Powders
keywords: CV cardiovascular; FDSP freeze-dried strawberry powder; NO nitric oxide; Nitrate; Obese adolescents; PAT peripheral arterial tonometry; Peripheral arterial tonometry; RHI reactive hyperaemia index; Strawberry powder; fRHI Framingham reactive hyperaemia index