title: Impact of the Daily Use of a Microcrystal Hydroxyapatite Dentifrice on De Novo Plaque Formation and Clinical/Microbiological Parameters of Periodontal Health. A Randomized Trial.
abstract: OBJECTIVE
  This 12-week prospective, randomized, double-blind, two-center trial evaluated the impact of a microcrystalline zinc hydroxyapatite (mHA) dentifrice on plaque formation rate (PFR) in chronic periodontitis patients. We hypothesized that mHA precipitates cause delayed plaque development when compared to a fluoridated control (AmF/SnF2), and therefore would improve periodontal health.
  
  
  METHODS
  At baseline and after 4 and 12 weeks, PFR and other clinical and microbiological parameters were recorded. Seventy periodontitis patients received a mHA or AmF/SnF2 dentifrice as daily oral care without hygiene instructions. Four weeks after baseline, participants received full mouth debridement and continued using the dentifrices for another 8 weeks.
  
  
  RESULTS
  Primary outcome PFR did not change statistically significantly from baseline to weeks 4 and 12, neither in mHA (n = 33; 51.7±17.2% vs. 48.5±16.65% vs. 48.4±19.9%) nor in AmF/SnF2-group (n = 34; 52.3±17.5% vs. 52.5±21.3% vs. 46.1±21.8%). Secondary clinical parameters such as plaque control record, gingival index, bleeding on probing, and pocket probing depth improved, but between-group differences were not statistically significant. Microbiological analyses showed similar slight decreases in colony-forming units in both groups.
  
  
  CONCLUSIONS
  In patients with mild-to-moderate periodontitis, periodontal therapy and use of a mHA-or AmF/SnF2 dentifrice without instructions induced comparable improvements in periodontal health but did not significantly reduce the PFR.
  
  
  BACKGROUND
  ClincalTrials.gov NCT02697539.
authors.affiliation: Department of Periodontology, University Hospital Muenster, Muenster, Germany.
authors.forename: Inga
authors.initials: I
authors.lastname: Harks
authors.affiliation: Department of Periodontology, University Hospital Wuerzburg, Wuerzburg, Germany.
authors.forename: Yvonne
authors.initials: Y
authors.lastname: Jockel-Schneider
authors.affiliation: Department of Periodontology, University Hospital Wuerzburg, Wuerzburg, Germany.
authors.forename: Ulrich
authors.initials: U
authors.lastname: Schlagenhauf
authors.affiliation: Society for Biometry and Psychometry, Bielefeld, Germany.
authors.forename: Theodor W
authors.initials: TW
authors.lastname: May
authors.affiliation: Department of Periodontology, University Hospital Muenster, Muenster, Germany.
authors.forename: Martina
authors.initials: M
authors.lastname: Gravemeier
authors.affiliation: Department of Periodontology, University Hospital Muenster, Muenster, Germany.
authors.forename: Karola
authors.initials: K
authors.lastname: Prior
authors.affiliation: Department of Periodontology, University Hospital Muenster, Muenster, Germany.|Private Practice, Wuerzburg, Germany.
authors.forename: Gregor
authors.initials: G
authors.lastname: Petersilka
authors.affiliation: Department of Periodontology, University Hospital Muenster, Muenster, Germany.
authors.forename: Benjamin
authors.initials: B
authors.lastname: Ehmke
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D015169:Colony Count, Microbial; D003460:Crystallization; D003773:Dental Plaque; D003802:Dentifrices / Q000627:therapeutic use*; D004311:Double-Blind Method; D017886:Durapatite / Q000737:chemistry / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010316:Particle Size; D010519:Periodontium / Q000382:microbiology / Q000502:physiology*; D055815:Young Adult
chemical_list: D003802:Dentifrices; D017886:Durapatite