title: Tumour volumes: Predictors of early treatment response in locally advanced head and neck cancers treated with definitive chemoradiation.
abstract: OBJECTIVE
  To analyse and predict early response 3 months post definitive chemoradiation (CCRT) utilising tumour volume (TV) measurement in locally advanced head and neck cancers (LAHNC).
  
  
  BACKGROUND
  LAHNC are 3-dimentional lesions. The largest diameter of these tumours measured for T-classification may not necessarily reflect the true tumour dimensions. TV accurately reflects the tumour burden because it is a measurement of tumour burden in all three dimensions.
  
  
  METHODS
  It is a single institutional prospective study including 101 patients with LAHNC treated with definitive CCRT. TV data noted were primary tumour volume (PTV), total nodal volume (TNV) and total tumour volume (TTV). Response evaluation was done at 3 months after the completion of definitive CCRT and patients were categorised either having achieved complete response (CR) or residual disease.
  
  
  RESULTS
  Patients who had not achieved CR were found to have larger TV compared with those who had achieved CR. There were significant inverse correlations between PTV and response (median 16.37 cm(3) vs. 45.2 cm(3); p = 0.001), and between TTV and response (median 36.14 cm(3) vs. 66.06 cm(3); p < 0.001). Receiver operating characteristic (ROC) analysis identified an "optimal cut-off" value of 41 cm(3) for PTV and 42 cm(3) for TTV above and below which the magnitude of difference in response was the greatest.
  
  
  CONCLUSIONS
  If response evaluation 3 months post CCRT is to be predicted it is simply not enough to measure the largest single dimension of the tumour. TV seems to be a better and more accurate reflection of the true total tumour burden or extent of the disease.
authors.affiliation: Dept of Radiation Oncology, Rajiv Gandhi Cancer Institute and Research Centre, Sector 5, Rohini, New Delhi 110085, India.
authors.forename: Parveen
authors.initials: P
authors.lastname: Ahlawat
authors.affiliation: Dept of Radiation Oncology, Rajiv Gandhi Cancer Institute and Research Centre, Sector 5, Rohini, New Delhi 110085, India.
authors.forename: Sheh
authors.initials: S
authors.lastname: Rawat
authors.affiliation: Dept of Radiation Oncology, Rajiv Gandhi Cancer Institute and Research Centre, Sector 5, Rohini, New Delhi 110085, India.
authors.forename: Anjali
authors.initials: A
authors.lastname: Kakria
authors.affiliation: Dept of Radiation Oncology, Rajiv Gandhi Cancer Institute and Research Centre, Sector 5, Rohini, New Delhi 110085, India.
authors.forename: Manoj
authors.initials: M
authors.lastname: Pal
authors.affiliation: Dept of Radiation Oncology, Rajiv Gandhi Cancer Institute and Research Centre, Sector 5, Rohini, New Delhi 110085, India.
authors.forename: Deepika
authors.initials: D
authors.lastname: Chauhan
authors.affiliation: Dept of Radiation Oncology, Rajiv Gandhi Cancer Institute and Research Centre, Sector 5, Rohini, New Delhi 110085, India.
authors.forename: Sarthak
authors.initials: S
authors.lastname: Tandon
authors.affiliation: Dept of Radiation Oncology, Rajiv Gandhi Cancer Institute and Research Centre, Sector 5, Rohini, New Delhi 110085, India.
authors.forename: Shraddha
authors.initials: S
authors.lastname: Jain
keywords: Chemoradiation; Early response; Head neck; Prognostic factors; Tumour volume