title: One-Pot Synthesis of 2-Cyano-1,4-diketones: Applications to Synthesis of Cyanosubstituted Furans, Pyrroles, and Dihydropyridazines.
abstract: A convenient synthetic route for the construction of functionalized 2-cyano-1,4-diketones has been established from the nucleophilic substitution of 2-bromoacetophenones with NaCN via the in situ-generated β-ketonitriles. This method was further applied to the synthesis of cyanosubstituted furans, pyrroles, or dihydropyridazines, which were obtained in good to excellent yields using Bi(OTf)3, NH4OAc, or N2H4. The key structures were confirmed by X-ray single crystal diffraction analysis.
authors.affiliation: Department of Medicinal and Applied Chemistry, and General Research Centers of R&D office, Kaohsiung Medical University , Kaohsiung 807, Taiwan.
authors.forename: Chieh-Kai
authors.initials: CK
authors.lastname: Chan
authors.affiliation: Department of Medicinal and Applied Chemistry, and General Research Centers of R&D office, Kaohsiung Medical University , Kaohsiung 807, Taiwan.
authors.forename: Yi-Ling
authors.initials: YL
authors.lastname: Chan
authors.affiliation: Department of Medicinal and Applied Chemistry, and General Research Centers of R&D office, Kaohsiung Medical University , Kaohsiung 807, Taiwan.
authors.forename: Yu-Lin
authors.initials: YL
authors.lastname: Tsai
authors.affiliation: Department of Medicinal and Applied Chemistry, and General Research Centers of R&D office, Kaohsiung Medical University , Kaohsiung 807, Taiwan.
authors.forename: Meng-Yang
authors.initials: MY
authors.lastname: Chang