title: Therapeutic potential of coumarins as antiviral agents.
abstract: Coumarins have received a considerable attention in the last three decades as a lead structures for the discovery of orally bioavailable non-peptidic antiviral agents. A lot of structurally diverse coumarins analogues were found to display remarkable array of affinity with the different molecular targets for antiviral agents and slight modifications around the central motif result in pronounced changes in its antiviral spectrum. This manuscript thoroughly reviews the design, discovery and structure-activity relationship studies of the coumarin analogues as antiviral agents focusing mainly on lead optimization and its development into clinical candidates.
authors.affiliation: School of Chemical Sciences, Universiti Sains Malaysia, Minden, 11800 Penang, Malaysia; Department of Pharmaceutical Chemistry, Alwar Pharmacy College, M.I.A., Alwar, Rajasthan 301030, India. Electronic address: drzahin@gmail.com.
authors.forename: Mohd Zaheen
authors.initials: MZ
authors.lastname: Hassan
authors.affiliation: School of Chemical Sciences, Universiti Sains Malaysia, Minden, 11800 Penang, Malaysia. Electronic address: ohasnah@usm.my.
authors.forename: Hasnah
authors.initials: H
authors.lastname: Osman
authors.affiliation: Institute for Research in Molecular Medicine, Universiti Sains Malaysia, Minden, 11800 Penang, Malaysia.
authors.forename: Mohamed Ashraf
authors.initials: MA
authors.lastname: Ali
authors.affiliation: Maharishi Arvind College of Pharmacy, Ambabari, Jaipur 302 039, India.
authors.forename: Mohamed Jawed
authors.initials: MJ
authors.lastname: Ahsan
mesh_terms: D000998:Antiviral Agents / Q000737:chemistry / Q000494:pharmacology*; D003374:Coumarins / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D058990:Molecular Targeted Therapy
chemical_list: D000998:Antiviral Agents; D003374:Coumarins
keywords: Anti-HCV; Anti-HIV; Anti-herpes; Anti-influenza; Antiviral; Coumarin