title: Cytochrome and sulfotransferase gene variation in north African populations.
abstract: To describe the diversity of four cytochrome and four sulfotransferase polymorphisms in six north African samples. Scarce data have been compiled for these samples despite the rich genetic background of north African populations.
  
  
  
  CYP3A4*1B, CYP3A4*17, CYP3A4*3, CYP3A5*3, SULT1A1*2, SULT1A2*2, SULT1A2*3 and SULT1E1*2 polymorphisms were explored in 556 individuals from Morocco, Algeria, Tunisia and Libya.
  
  
  
  Allele frequencies in our samples largely exceeded the variation ranges described for European populations, especially for CYP3A4*1B, SULT1A1*2 and SULT1A2*3.
  
  
  
  North African populations are heterogeneous, genetically diverse and show a considerable sub-Saharan African contribution for markers associated with increased risk of prostate cancer and with differential drug metabolism.
authors.affiliation: Basic Biomedical Sciences Department, Universidad Europea de Madrid, Madrid, Spain.
authors.forename: Ana
authors.initials: A
authors.lastname: Fernández-Santander
authors.affiliation: Basic Biomedical Sciences Department, Universidad Europea de Madrid, Madrid, Spain.
authors.forename: Apolonia
authors.initials: A
authors.lastname: Novillo
authors.affiliation: Basic Biomedical Sciences Department, Universidad Europea de Madrid, Madrid, Spain.
authors.forename: María
authors.initials: M
authors.lastname: Gaibar
authors.affiliation: Basic Biomedical Sciences Department, Universidad Europea de Madrid, Madrid, Spain.
authors.forename: Alicia
authors.initials: A
authors.lastname: Romero-Lorca
authors.affiliation: Section of Zoology and Anthropology, Department of Evolutive Biology, Ecology and Environmental Sciences, Faculty of Biology, University of Barcelona, Barcelona, Spain.|Institut de Recerca de la Biodiversitat (IRBio), Universitat de Barcelona, Barcelona, Spain.
authors.forename: Pedro
authors.initials: P
authors.lastname: Moral
authors.affiliation: Departamento de Genética, Antropología Física y Fisiología Animal (UPV/EHU), Leioa, Spain.
authors.forename: David
authors.initials: D
authors.lastname: Sánchez-Cuenca
authors.affiliation: Laboratoire de Biochimie Appliquée, Faculté des Sciences de la Nature et de la Vie, Université de Bejaia, Algeria.
authors.forename: Nadir
authors.initials: N
authors.lastname: Amir
authors.affiliation: Faculty of Pharmacy, University of Monastir, Monastir, Tunisia.
authors.forename: Hassen
authors.initials: H
authors.lastname: Chaabani
authors.affiliation: Départément de Biologie, Faculté des Sciences, Université Chouaib Doukkali, El Jadida, Morocco.
authors.forename: Nourdin
authors.initials: N
authors.lastname: Harich
authors.affiliation: Section of Zoology and Anthropology, Department of Evolutive Biology, Ecology and Environmental Sciences, Faculty of Biology, University of Barcelona, Barcelona, Spain.|Institut de Recerca de la Biodiversitat (IRBio), Universitat de Barcelona, Barcelona, Spain.
authors.forename: Maria Esther
authors.initials: ME
authors.lastname: Esteban
mesh_terms: D000352:Africa, Northern / Q000453:epidemiology; D044383:Black People / Q000235:genetics*; D003580:Cytochromes / Q000235:genetics*; D005006:Ethnicity; D005787:Gene Frequency / Q000235:genetics; D014644:Genetic Variation / Q000235:genetics*; D006801:Humans; D015810:Linkage Disequilibrium; D008297:Male; D011110:Polymorphism, Genetic / Q000235:genetics; D011471:Prostatic Neoplasms / Q000453:epidemiology / Q000235:genetics; D015238:Sulfotransferases / Q000235:genetics*
chemical_list: D003580:Cytochromes; D015238:Sulfotransferases
keywords: cytochrome; genetic diversity; north African populations; sulfotransferase