title: The use of micro-electro mechanical systems in vascular monitoring: implications for clinical use.
abstract: BACKGROUND
  BioMEMS relates to the implementation of Micro-Electro-Mechanical Systems (MEMS), in the biological and medical sphere. BioMEMS sensors are being utilized for many clinical applications, including a wireless urinary pressure system, right heart pressure sensor, and measurements on shearing force on the vascular system An important application of BioMEMS is on Heart failure (HF), a common disease, with a prevalence of 10% or more in persons 70 years of age or older, associated with high morbidity and mortality. HF affects over 5 million people and contributes to over 200,000 deaths a year in the United States alone.
  
  
  METHODS
  The purpose of this paper is to provide a short overview on the successful implementation of BioMEMS sensors in heart failure and vascular medicine. Expert commentary: BioMEMS devices have overcome current limitations in pharmacotherapies for resistant hypertension by electrical modulation of the baroreceeptors. This represents a step towards the development of biomedical micro-devices for those conditions in which pharmacotherapies result poorly effective or elicit unacceptable toxicity.
authors.affiliation: a Superior Nano Biosystems LLC , Highland Park , NJ , USA.
authors.forename: Mahyar
authors.initials: M
authors.lastname: Pourriahi
authors.affiliation: b Department of Materials Science and Engineering , University of Texas- Dallas , Richardson , Texas , USA.
authors.forename: Pablo
authors.initials: P
authors.lastname: Gurman
authors.affiliation: a Superior Nano Biosystems LLC , Highland Park , NJ , USA.
authors.forename: Jonathan
authors.initials: J
authors.lastname: Daich
authors.affiliation: a Superior Nano Biosystems LLC , Highland Park , NJ , USA.
authors.forename: Philip
authors.initials: P
authors.lastname: Cynamon
authors.affiliation: a Superior Nano Biosystems LLC , Highland Park , NJ , USA.
authors.forename: Aaron
authors.initials: A
authors.lastname: Richler
authors.affiliation: c Materials Division, Bio Group , Charles Stark Draper Laboratories , Cambridge , MA , USA.|d Center for Innovations in Care Delivery , Massachusetts General Hospital , Boston , MA , USA.
authors.forename: Noel
authors.initials: N
authors.lastname: Elman
authors.affiliation: a Superior Nano Biosystems LLC , Highland Park , NJ , USA.
authors.forename: Yitzhak
authors.initials: Y
authors.lastname: Rosen
mesh_terms: D002309:Cardiology; D002986:Clinical Trials as Topic; D006333:Heart Failure / Q000175:diagnosis; D006801:Humans; D055617:Micro-Electrical-Mechanical Systems / Q000379:methods*; D008991:Monitoring, Physiologic / Q000379:methods*; D011312:Pressure
keywords: Micro-electro-mechanical systems; capacitive pressure sensors; catheter-tip-sensor; heart failure; piezoresistive pressure sensors; vascular monitoring; wireless implantable sensors