title: Modulation of cardiac autonomic tone in non-hypotensive hypovolemia during blood donation.
abstract: Non-hypotensive hypovolemia, observed during mild haemorrhage or blood donation leads to reflex readjustment of the cardiac autonomic tone. In the present study, the cardiac autonomic tone was quantified using heart rate and blood pressure variability during and after non-hypotensive hypovolemia of blood donation. 86 voluntary healthy male blood donors were recruited for the study (age 35 ± 9 years; weight 78 ± 12 kg; height 174 ± 6 cms). Continuous lead II ECG and beat-to-beat blood pressure was recorded before, during and after blood donation followed by offline time and frequency domain analysis of HRV and BPV. The overall heart rate variability (SDNN and total power) did not change during or after blood donation. However, there was a decrease in indices that represent the parasympathetic component (pNN50 %, SDSD and HF) while an increase was observed in sympathetic component (LF) along with an increase in sympathovagal balance (LF:HF ratio) during blood donation. These changes were sustained for the period immediately following blood donation. No fall of blood pressure was observed during the period of study. The blood pressure variability showed an increase in the SDNN, CoV and RMSSD time domain measures in the post donation period. These results suggest that mild hypovolemia produced by blood donation is non-hypotensive but is associated with significant changes in the autonomic tone. The increased blood pressure variability and heart rate changes that are seen only in the later part of donation period could be because of the progressive hypovolemia associated parasympathetic withdrawal and sympathetic activation that manifest during the course of blood donation.
authors.affiliation: Department of Physiology, All India Institute of Medical Sciences, Room No. 2009, Teaching Block, Second Floor, Ansari Nagar, New Delhi, India.
authors.forename: Kavita
authors.initials: K
authors.lastname: Yadav
authors.affiliation: Department of Physiology, All India Institute of Medical Sciences, Room No. 2009, Teaching Block, Second Floor, Ansari Nagar, New Delhi, India.
authors.forename: Akanksha
authors.initials: A
authors.lastname: Singh
authors.affiliation: Department of Physiology, All India Institute of Medical Sciences, Room No. 2009, Teaching Block, Second Floor, Ansari Nagar, New Delhi, India. ashok.jaryal@gmail.com.
authors.forename: Ashok Kumar
authors.initials: AK
authors.lastname: Jaryal
authors.affiliation: Transfusion Medicine (Blood Bank), All India Institute of Medical Sciences, Ansari Nagar, New Delhi, India.
authors.forename: Poonam
authors.initials: P
authors.lastname: Coshic
authors.affiliation: Transfusion Medicine (Blood Bank), All India Institute of Medical Sciences, Ansari Nagar, New Delhi, India.
authors.forename: Kabita
authors.initials: K
authors.lastname: Chatterjee
authors.affiliation: Department of Physiology, All India Institute of Medical Sciences, Room No. 2009, Teaching Block, Second Floor, Ansari Nagar, New Delhi, India.
authors.forename: K K
authors.initials: KK
authors.lastname: Deepak
mesh_terms: D000328:Adult; D001158:Arteries / Q000503:physiopathology; D001341:Autonomic Nervous System / Q000503:physiopathology*; D001782:Blood Donors; D001794:Blood Pressure / Q000502:physiology; D001795:Blood Pressure Determination; D004562:Electrocardiography; D006321:Heart / Q000503:physiopathology; D006339:Heart Rate / Q000502:physiology*; D006470:Hemorrhage / Q000503:physiopathology; D006801:Humans; D007022:Hypotension; D020896:Hypovolemia / Q000503:physiopathology*; D008297:Male; D008991:Monitoring, Physiologic; D010275:Parasympathetic Nervous System / Q000502:physiology; D011311:Pressoreceptors / Q000503:physiopathology; D012815:Signal Processing, Computer-Assisted; D013564:Sympathetic Nervous System / Q000502:physiology
keywords: Blood donation; Blood pressure variability; Heart rate; Heart rate variability; Non-hypotensive hypovolemia