title: Hemodynamic changes in a rat parietal cortex after endothelin-1-induced middle cerebral artery occlusion monitored by optical coherence tomography.
abstract: A blockage of the middle cerebral artery (MCA) on the cortical branch will seriously affect the blood supply of the cerebral cortex. Real-time monitoring of MCA hemodynamic parameters is critical for therapy and rehabilitation. Optical coherence tomography (OCT) is a powerful imaging modality that can produce not only structural images but also functional information on the tissue. We use OCT to detect hemodynamic changes after MCA branch occlusion. We injected a selected dose of endothelin-1 (ET-1) at a depth of 1 mm near the MCA and let the blood vessels follow a process first of occlusion and then of slow reperfusion as realistically as possible to simulate local cerebral ischemia. During this period, we used optical microangiography and Doppler OCT to obtain multiple hemodynamic MCA parameters. The change trend of these parameters from before to after ET-1 injection clearly reflects the dynamic regularity of the MCA. These results show the mechanism of the cerebral ischemia-reperfusion process after a transient middle cerebral artery occlusion and confirm that OCT can be used to monitor hemodynamic parameters.
authors.affiliation: Northeastern University, School of Information Science and Engineering, No. 11 Lane Three Culture Road, Heping Area, Shenyang 110819, China.
authors.forename: Jian
authors.initials: J
authors.lastname: Liu
authors.affiliation: Northeastern University, School of Information Science and Engineering, No. 11 Lane Three Culture Road, Heping Area, Shenyang 110819, China.
authors.forename: Yushu
authors.initials: Y
authors.lastname: Ma
authors.affiliation: Northeastern University, School of Information Science and Engineering, No. 11 Lane Three Culture Road, Heping Area, Shenyang 110819, China.
authors.forename: Shidan
authors.initials: S
authors.lastname: Dou
authors.affiliation: Northeastern University, School of Information Science and Engineering, No. 11 Lane Three Culture Road, Heping Area, Shenyang 110819, China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Northeastern University, School of Information Science and Engineering, No. 11 Lane Three Culture Road, Heping Area, Shenyang 110819, China.
authors.forename: Dongsheng
authors.initials: D
authors.lastname: La
authors.affiliation: Capital Medical University, Department of Neurology, Xuan Wu Hospital, No. 45 Changchun Street, Xicheng District, Beijing 100053, China.
authors.forename: Jianghong
authors.initials: J
authors.lastname: Liu
authors.affiliation: Northeastern University, School of Information Science and Engineering, No. 11 Lane Three Culture Road, Heping Area, Shenyang 110819, China.
authors.forename: Zhenhe
authors.initials: Z
authors.lastname: Ma
mesh_terms: D000818:Animals; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D019332:Endothelin-1 / Q000494:pharmacology*; D006439:Hemodynamics / Q000187:drug effects*; D020244:Infarction, Middle Cerebral Artery / Q000000981:diagnostic imaging* / Q000473:pathology; D010296:Parietal Lobe / Q000098:blood supply* / Q000187:drug effects*; D051381:Rats; D041623:Tomography, Optical Coherence
chemical_list: D019332:Endothelin-1