title: Nephroprotective Effect of Bauhinia tomentosa Linn against Cisplatin-Induced Renal Damage.
abstract: Cisplatin (CP) is an important chemotherapeutic drug used for the treatment of a wide variety of solid tumors. However, clinical use of CP has been limited due to its adverse effect of nephrotoxicity. In the present study, we evaluate the nephroprotective effect of Bauhinia tomentosa against CP-induced renal damage in rats. Administration of methonolic extract of B. tomentosa (250 mg/kg b.w.) results in a significant increase in antioxidant enzymes including superoxide dismutase (SOD), glutathione (GSH), and catalase (CAT). Furthermore, treatment with B. tomentosa increased body weight and relative organ weight when compared with that of the CP-induced control group. Moreover, treatment with B. tomentosa extract significantly decreased lipid peroxidation(LPO), serum urea, and creatinine when compared with the CP-induced control group. Thus, the present study highlights the potential role of B. tomentosa and its use as a new protective strategy against CP-induced nephrotoxicity.
authors.affiliation: Department of Biotechnology, Karunya University, Karunya Nagar, Coimbatore 641 114, Tamil Nadu, India.
authors.forename: Narayanan
authors.initials: N
authors.lastname: Kannan
authors.affiliation: Department of Biotechnology, Karunya University, Karunya Nagar, Coimbatore 641 114, Tamil Nadu, India.
authors.forename: Kunnathur Murugesan
authors.initials: KM
authors.lastname: Sakthivel
authors.affiliation: Division of Cancer Research, Regional Cancer Centre, Thiruvananthapuram - 695011, Kerala, India.
authors.forename: Chandrasekaran
authors.initials: C
authors.lastname: Guruvayoorappan
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000633:toxicity*; D000975:Antioxidants / Q000378:metabolism; D036481:Bauhinia / Q000737:chemistry*; D001835:Body Weight / Q000187:drug effects; D002945:Cisplatin / Q000037:antagonists & inhibitors* / Q000633:toxicity*; D007668:Kidney / Q000187:drug effects*; D008297:Male; D009929:Organ Size / Q000187:drug effects; D010936:Plant Extracts / Q000494:pharmacology*; D018515:Plant Leaves / Q000737:chemistry; D051381:Rats; D017208:Rats, Wistar
chemical_list: D000970:Antineoplastic Agents; D000975:Antioxidants; D010936:Plant Extracts; D002945:Cisplatin