title: Tetraspanin CD81, a modulator of immune suppression in cancer and metastasis.
abstract: Cancer cells can escape the antitumor immune response by recruiting immune suppressor cells. However, although innate myeloid-derived suppressor cells (MDSCs) and T regulatory (Treg) cells accumulate normally in tumor-bearing CD81-deficient mice, both populations are impaired in their ability to suppress the antitumor immune response.
authors.affiliation: Department of Medicine, Division of Oncology, Stanford University Medical Center , Stanford, CA, USA.
authors.forename: Felipe
authors.initials: F
authors.lastname: Vences-Catalán
authors.affiliation: Department of Medicine, Division of Oncology, Stanford University Medical Center , Stanford, CA, USA.
authors.forename: Ranjani
authors.initials: R
authors.lastname: Rajapaksa
authors.affiliation: Department of Medicine, Division of Oncology, Stanford University Medical Center , Stanford, CA, USA.
authors.forename: Minu K
authors.initials: MK
authors.lastname: Srivastava
authors.affiliation: Department of Medicine, Division of Oncology, Stanford University Medical Center , Stanford, CA, USA.
authors.forename: Aurelien
authors.initials: A
authors.lastname: Marabelle
authors.affiliation: Department of Medicine, Division of Oncology, Stanford University Medical Center , Stanford, CA, USA.
authors.forename: Chiung-Chi
authors.initials: CC
authors.lastname: Kuo
authors.affiliation: Department of Medicine, Division of Oncology, Stanford University Medical Center , Stanford, CA, USA.
authors.forename: Ronald
authors.initials: R
authors.lastname: Levy
authors.affiliation: Department of Medicine, Division of Oncology, Stanford University Medical Center , Stanford, CA, USA.
authors.forename: Shoshana
authors.initials: S
authors.lastname: Levy
keywords: CD81 knockout (CD81KO) mice; T regulatory (Treg) cells; myeloid-derived suppressor cells (MDSCs); tumor