title: Nephroprotective and antioxidant properties of Artemisia arborescens hydroalcoholic extract against oestroprogestative-induced kidney damages in rats.
abstract: OBJECTIVE
  Currently, medicinal plants are found to have biological and pharmacological activities and are used in various domains. This study, carried out on Wistar rats, evaluates the beneficial effects of Artemisia arborscens extract on oestroprogestative-induced damages in kidney.
  
  
  METHODS
  Thirty-six 3-month-old Wistar rats were divided into 4 batches of nine each: a control group, a group of rats receiving oestroprogestative treatment, a group undergoing oestroprogestative treatment after receiving Artemisia arborescens extract in drinking water, and a group that received only Artemisia arborescens.
  
  
  RESULTS
  Artemisia arborescens extract was found to optimize many parameters which were shifted to pathological values as a consequence of oestroprogestative toxicity: plasma creatinine and urea levels were decreased, uric acid and proteins were restored to normal values. The alteration of renal architecture was also suppressed. In addition, superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPX) activities that had been reduced in kidney of the treated group were restored by Aretmisia arborscens-based treatments and, therefore, the lipid peroxidation level was reduced in the renal tissue compared to the control group.
  
  
  CONCLUSIONS
  The obtained results confirmed that the Artemisia-based treatment allowed efficient protection against oestroprogestative-induced nephrotoxicity by restoring the activities of kidney. The protective effect of Artemisia arborescens was mainly attributed to antioxidant properties as well as the presence of phenolic acids and flavonoids detected by means of HPLC.
authors.affiliation: Laboratory of Animal Ecophysiology, Unit of Environmental Pathophysiology, Development of Bioactive Molecules and Mathematical Modelling, Sfax, Tunisia. Electronic address: s.dhibi@yahoo.fr.
authors.forename: Sabah
authors.initials: S
authors.lastname: Dhibi
authors.affiliation: Laboratory of Animal Ecophysiology, Unit of Environmental Pathophysiology, Development of Bioactive Molecules and Mathematical Modelling, Sfax, Tunisia.
authors.forename: Hafsia
authors.initials: H
authors.lastname: Bouzenna
authors.affiliation: Laboratory of Animal Ecophysiology, Unit of Environmental Pathophysiology, Development of Bioactive Molecules and Mathematical Modelling, Sfax, Tunisia.
authors.forename: Noura
authors.initials: N
authors.lastname: Samout
authors.affiliation: The Higher Institute of Business Administration of Gafsa, University of Gafsa, Tunisia.
authors.forename: Zied
authors.initials: Z
authors.lastname: Tlili
authors.affiliation: Laboratory of Animal Ecophysiology, Unit of Environmental Pathophysiology, Development of Bioactive Molecules and Mathematical Modelling, Sfax, Tunisia.
authors.forename: Abdelfettah
authors.initials: A
authors.lastname: Elfeki
authors.affiliation: Laboratory of Animal Ecophysiology, Unit of Environmental Pathophysiology, Development of Bioactive Molecules and Mathematical Modelling, Sfax, Tunisia.
authors.forename: Najla
authors.initials: N
authors.lastname: Hfaiedh
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D019306:Artemisia / Q000737:chemistry*; D015415:Biomarkers / Q000097:blood; D001713:Biphenyl Compounds / Q000737:chemistry; D002851:Chromatography, High Pressure Liquid; D004958:Estradiol / Q000009:adverse effects*; D000431:Ethanol / Q000737:chemistry; D016166:Free Radical Scavengers / Q000494:pharmacology; D007668:Kidney / Q000187:drug effects / Q000473:pathology*; D015227:Lipid Peroxidation / Q000187:drug effects; D010084:Oxidation-Reduction / Q000187:drug effects; D010851:Picrates / Q000737:chemistry; D010936:Plant Extracts / Q000494:pharmacology*; D011374:Progesterone / Q000009:adverse effects*; D020011:Protective Agents / Q000494:pharmacology*; D017208:Rats, Wistar; D014867:Water / Q000737:chemistry
chemical_list: D000975:Antioxidants; D015415:Biomarkers; D001713:Biphenyl Compounds; D016166:Free Radical Scavengers; D010851:Picrates; D010936:Plant Extracts; D020011:Protective Agents; D014867:Water; D000431:Ethanol; D011374:Progesterone; D004958:Estradiol; C004931:1,1-diphenyl-2-picrylhydrazyl
keywords: Artemisia arborescens extract; Oestroprogestative treatment; Oxidative stress