title: Acute Methiopropamine Intoxication After "Synthacaine" Consumption.
abstract: Use of methiopropamine (MPA), a synthetic metamfetamine analog, has been detected since 2011 in Europe, but there is limited information on its acute toxicity. A 30-year-old man was admitted to the emergency department in a confused state, with paranoid delusion, auditory and visual hallucinatory experiences, and incoherent speech following the use of "synthacaine" (a slang term derived from "synthetic" and "cocaine"). Toxicological screening for pharmaceuticals and drugs of abuse by liquid chromatography-diode-array detector, gas chromatography-mass spectrometry and liquid chromatography-tandem mass spectrometry (LC-MS-MS) detected MPA, which was subsequently quantified by a specific LC-MS-MS method. Of note, 13 h after presentation to the emergency department, the plasma concentration of MPA was 14 ng/mL. This case report confirms the toxicity of MPA and the need for toxicological analysis to confirm the substance actually ingested by users of new psychoactive substances.
authors.affiliation: Service de pharmacologie médicale, centre d'addictovigilance, CHU Bordeaux.
authors.forename: A
authors.initials: A
authors.lastname: Daveluy
authors.affiliation: Service de pharmacologie médicale, laboratoire de pharmacologie-toxicologie, CHU Bordeaux.
authors.forename: N
authors.initials: N
authors.lastname: Castaing
authors.affiliation: Service des urgences, CHU Bordeaux.
authors.forename: H
authors.initials: H
authors.lastname: Cherifi
authors.affiliation: CHU Lille, Unité Fonctionnelle de Toxicologie, F-59000 Lille, France.
authors.forename: C
authors.initials: C
authors.lastname: Richeval
authors.affiliation: CHU Lille, Unité Fonctionnelle de Toxicologie, F-59000 Lille, France.
authors.forename: L
authors.initials: L
authors.lastname: Humbert
authors.affiliation: Service des urgences, CHU Bordeaux.
authors.forename: I
authors.initials: I
authors.lastname: Faure
authors.affiliation: Centre anti-poison, CHU Bordeaux.
authors.forename: M
authors.initials: M
authors.lastname: Labadie
authors.affiliation: CHU Lille, Unité Fonctionnelle de Toxicologie, F-59000 Lille, France.
authors.forename: D
authors.initials: D
authors.lastname: Allorge
authors.affiliation: Service de pharmacologie médicale, centre d'addictovigilance, CHU Bordeaux.
authors.forename: F
authors.initials: F
authors.lastname: Haramburu
authors.affiliation: Service de pharmacologie médicale, laboratoire de pharmacologie-toxicologie, CHU Bordeaux.
authors.forename: M
authors.initials: M
authors.lastname: Molimard
authors.affiliation: Service de pharmacologie médicale, laboratoire de pharmacologie-toxicologie, CHU Bordeaux karine.titier@chu-bordeaux.fr.
authors.forename: K
authors.initials: K
authors.lastname: Titier
mesh_terms: D002138:Calibration; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D008401:Gas Chromatography-Mass Spectrometry; D006801:Humans; D013287:Illicit Drugs / Q000097:blood / Q000633:toxicity* / Q000652:urine; D007118:Immunoassay; D059625:Liquid-Liquid Extraction; D008297:Male; D008694:Methamphetamine / Q000031:analogs & derivatives* / Q000097:blood / Q000633:toxicity* / Q000652:urine; D021241:Spectrometry, Mass, Electrospray Ionization; D019966:Substance-Related Disorders / Q000097:blood / Q000378:metabolism* / Q000652:urine; D053719:Tandem Mass Spectrometry; D013876:Thiophenes / Q000097:blood / Q000633:toxicity* / Q000652:urine
chemical_list: C583008:1-(2-thienyl)-2-(methylamino)propane; D013287:Illicit Drugs; D013876:Thiophenes; D008694:Methamphetamine