title: Association of NKAPL, TSPAN18, and MPC2 gene variants with schizophrenia based on new data and a meta-analysis in Han Chinese.
abstract: BACKGROUND
  Schizophrenia (SZ) is suggested to be a complex polygenetic disorder with high heritability. Genome-wide association studies have found that the rs1635, rs11038167, and rs10489202 polymorphisms are associated with SZ in Han Chinese. However, results of validation studies are inconsistent. This study aimed to test the association between the NKAPL rs1635, TSPAN18 rs11038167, and MPC2 rs10489202 polymorphisms and SZ in a Chinese population.
  
  
  METHODS
  This study contained 700 unrelated SZ patients (300 Zhuang and 400 Han) and 700 gender- and age-matched controls (300 Zhuang and 400 Han). The polymorphisms in TSPAN18 (rs11038167), NKAPL (rs1635), and MPC2 (rs10489202) were genotyped using the Sequenom MassARRAY method. Statistical analyses were performed with PLINK program and SPSS l6.0 for Windows. STATA11.1 was used for meta-analysis.
  
  
  RESULTS
  No statistically significant difference was found in different allele and genotype frequencies of rs1635, rs11038167, and rs10489202 between SZ cases and controls of Zhuang and Han ethnicities and the total samples (all p>0.05). Further meta-analysis suggested that single-nucleotide polymorphism rs10489202 was significantly associated with SZ in a Han Chinese population (p OR=0.002).
  
  
  CONCLUSIONS
  Our case-control study failed to validate the significant association of NKAPL rs1635, TSPAN18 rs11038167, and MPC2 rs10489202 polymorphisms with SZ susceptibility in the southern Zhuang or Han Chinese population. However, meta-analysis showed a significant association between MPC2 variant rs10489202 and SZ susceptibility in Han Chinese.
authors.affiliation: 1School of Public Health,Guangxi Medical University,Nanning,Guangxi,China.
authors.forename: Zhen
authors.initials: Z
authors.lastname: Li
authors.affiliation: 3First Affiliated Hospital,Guangxi University of Chinese Medicine,Nanning,Guangxi,China.
authors.forename: Tingting
authors.initials: T
authors.lastname: Shen
authors.affiliation: 4Chinese Center for Disease Control and Prevention,Nanning,Guangxi,China.
authors.forename: Ran
authors.initials: R
authors.lastname: Xin
authors.affiliation: 3First Affiliated Hospital,Guangxi University of Chinese Medicine,Nanning,Guangxi,China.
authors.forename: Baoyun
authors.initials: B
authors.lastname: Liang
authors.affiliation: 1School of Public Health,Guangxi Medical University,Nanning,Guangxi,China.
authors.forename: Juan
authors.initials: J
authors.lastname: Jiang
authors.affiliation: 1School of Public Health,Guangxi Medical University,Nanning,Guangxi,China.
authors.forename: Weijun
authors.initials: W
authors.lastname: Ling
authors.affiliation: 1School of Public Health,Guangxi Medical University,Nanning,Guangxi,China.
authors.forename: Bo
authors.initials: B
authors.lastname: Wei
authors.affiliation: 1School of Public Health,Guangxi Medical University,Nanning,Guangxi,China.
authors.forename: Li
authors.initials: L
authors.lastname: Su
mesh_terms: D000328:Adult; D027321:Anion Transport Proteins / Q000235:genetics*; D044466:Asian People; D016022:Case-Control Studies; D002681:China / Q000453:epidemiology; D056970:Co-Repressor Proteins / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D005838:Genotype; D006801:Humans; D008297:Male; D033681:Mitochondrial Membrane Transport Proteins / Q000235:genetics*; D009687:Nuclear Proteins / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D012559:Schizophrenia / Q000235:genetics*; D059470:Tetraspanins / Q000235:genetics*
chemical_list: D027321:Anion Transport Proteins; D056970:Co-Repressor Proteins; C000595572:MPC2 protein, human; D033681:Mitochondrial Membrane Transport Proteins; C569368:NKAPL protein, human; D009687:Nuclear Proteins; C556852:TSPAN18 protein, human; D059470:Tetraspanins
keywords: 
                 MPC2
              ; 
                 NKAPL
              ; 
                 TSPAN18
              ; association studies; schizophrenia