title: A Survey of BRCA1, BRCA2, and PALB2 mutations in women with breast cancer in Trinidad and Tobago.
abstract: The mortality rate from breast cancer in the nation of Trinidad and Tobago is among the highest of any country in the Caribbean region. The contribution of inherited gene mutations to the burden of breast cancer in Trinidad and Tobago has not been studied. We examined the prevalence of mutations in three susceptibility genes (BRCA1, BRCA2, and PALB2) in breast cancer patients in Trinidad and Tobago. We studied 268 unselected breast cancer patients from Trinidad and Tobago and looked for mutations across the entire coding sequences of BRCA1, BRCA2, and PALB2. Overall, 28 of 268 patients (10.4 %) had a mutation in one of the three genes, including 15 in BRCA1, ten in BRCA2, two in PALB2, and one in both BRCA2 and PALB2. There were 25 different mutations identified; of these, four mutations were seen in two patients each. Given the high prevalence of mutations, it is reasonable to offer genetic testing for these three genes to all breast cancer patients in Trinidad and Tobago.
authors.affiliation: Sylvester Comprehensive Cancer Center, University of Miami, 1475 NW 12th Avenue, D8-4, Miami, FL, 33136, USA.
authors.forename: Talia
authors.initials: T
authors.lastname: Donenberg
authors.affiliation: Women's College Research Institute, University of Toronto, Toronto, Canada.|Institute of Medical Science, University of Toronto, Toronto, Canada.
authors.forename: Humayun
authors.initials: H
authors.lastname: Ahmed
authors.affiliation: Women's College Research Institute, University of Toronto, Toronto, Canada.
authors.forename: Robert
authors.initials: R
authors.lastname: Royer
authors.affiliation: Women's College Research Institute, University of Toronto, Toronto, Canada.
authors.forename: Shiyu
authors.initials: S
authors.lastname: Zhang
authors.affiliation: Women's College Research Institute, University of Toronto, Toronto, Canada.|Institute of Medical Science, University of Toronto, Toronto, Canada.|Dalla Lana School of Public Health, University of Toronto, Toronto, Canada.
authors.forename: Steven A
authors.initials: SA
authors.lastname: Narod
authors.affiliation: Sylvester Comprehensive Cancer Center, University of Miami, 1475 NW 12th Avenue, D8-4, Miami, FL, 33136, USA.
authors.forename: Sophia
authors.initials: S
authors.lastname: George
authors.affiliation: Women's College Research Institute, University of Toronto, Toronto, Canada.|Institute of Medical Science, University of Toronto, Toronto, Canada.|Dalla Lana School of Public Health, University of Toronto, Toronto, Canada.
authors.forename: Mohammad R
authors.initials: MR
authors.lastname: Akbari
authors.affiliation: Breast Surgery Unit, St. James Medical Complex, Northwest Regional Health Authority, Trinidad and Tobago, Division of General and Breast Surgery, University of Toronto, Toronto, Canada.
authors.forename: Jameel
authors.initials: J
authors.lastname: Ali
authors.affiliation: Sylvester Comprehensive Cancer Center, University of Miami, 1475 NW 12th Avenue, D8-4, Miami, FL, 33136, USA. jhurley@miami.edu.
authors.forename: Judith
authors.identifier: 0000-0002-0879-6184
authors.initials: J
authors.lastname: Hurley
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D019313:BRCA1 Protein / Q000235:genetics*; D024682:BRCA2 Protein / Q000235:genetics*; D001943:Breast Neoplasms / Q000453:epidemiology / Q000235:genetics*; D000076164:Fanconi Anemia Complementation Group N Protein / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D015994:Incidence; D008875:Middle Aged; D009154:Mutation; D059645:Mutation Rate; D015995:Prevalence; D017422:Sequence Analysis, DNA; D011795:Surveys and Questionnaires; D014300:Trinidad and Tobago / Q000453:epidemiology; D055815:Young Adult
chemical_list: D019313:BRCA1 Protein; C492913:BRCA1 protein, human; D024682:BRCA2 Protein; C551750:BRCA2 protein, human; D000076164:Fanconi Anemia Complementation Group N Protein; C512790:PALB2 protein, human
keywords: BRCA1; Bahamas; Breast cancer; Hereditary