title: The Present and Future of Genomics in Adult Reconstructive Orthopaedic Surgery.
abstract: As of 2015, members of the "baby boomer generation" comprise 75 million people in the growing United States population. Many of these individuals will be facing the need for total hip or knee replacement. Currently, the age of onset of osteoarthritis continues to decrease and the need for total joint replacements continues to increase. In current practice, nearly all patients undergoing joint replacement receive similar preoperative, intraoperative, and postoperative management strategies. However, wide variability in outcomes and satisfaction with total joint replacement still remain. The key to understanding the cause for such varied outcomes may lie in our understanding of the genetic basis of degenerative joint disease. The future of "orthogenomic" research should be centered on clinical application focusing on early preoperative identification of at-risk patients. The goal is to establish twenty-first-century patient-specific strategies for optimizing results and expectations after adult reconstructive surgery.
authors.affiliation: David Geffen School of Medicine at the University of California, Los Angeles, Los Angeles, California.|Department of Orthopaedic Surgery, New York University Langone Medical Center, Hospital for Joint Diseases, New York, NY.
authors.forename: Ameer
authors.initials: A
authors.lastname: Elbuluk
authors.affiliation: Department of Orthopaedic Surgery, New York University Langone Medical Center, Hospital for Joint Diseases, New York, NY.
authors.forename: Ajit
authors.initials: A
authors.lastname: Deshmukh
authors.affiliation: Department of Orthopaedic Surgery, New York University Langone Medical Center, Hospital for Joint Diseases, New York, NY.
authors.forename: Ifeoma
authors.initials: I
authors.lastname: Inneh
authors.affiliation: Department of Orthopaedic Surgery, New York University Langone Medical Center, Hospital for Joint Diseases, New York, NY.
authors.forename: Richard
authors.initials: R
authors.lastname: Iorio
mesh_terms: D000328:Adult; D019644:Arthroplasty, Replacement, Hip; D019645:Arthroplasty, Replacement, Knee; D023281:Genomics / Q000639:trends*; D006801:Humans; D009985:Orthopedics / Q000639:trends*; D010003:Osteoarthritis / Q000235:genetics / Q000601:surgery