title: Antibiotic drug discovery.
abstract: Due to the threat posed by the increase of highly resistant pathogenic bacteria, there is an urgent need for new antibiotics; all the more so since in the last 20 years, the approval for new antibacterial agents had decreased. The field of natural product discovery has undergone a tremendous development over the past few years. This has been the consequence of several new and revolutionizing drug discovery and development techniques, which is initiating a 'New Age of Antibiotic Discovery'. In this review, we concentrate on the most significant discovery approaches during the last and present years and comment on the challenges facing the community in the coming years.
authors.affiliation: Interfaculty Institute of Microbiology and Infection Medicine Tuebingen, Microbiology/Biotechnology, University of Tuebingen, Auf der Morgenstelle 28, 72076, Tuebingen, Germany.|German Center for Infection Research (DZIF), Partner Site Tuebingen, Tuebingen, Germany.
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Wohlleben
authors.affiliation: Interfaculty Institute of Microbiology and Infection Medicine Tuebingen, Microbiology/Biotechnology, University of Tuebingen, Auf der Morgenstelle 28, 72076, Tuebingen, Germany.|German Center for Infection Research (DZIF), Partner Site Tuebingen, Tuebingen, Germany.
authors.forename: Yvonne
authors.initials: Y
authors.lastname: Mast
authors.affiliation: Interfaculty Institute of Microbiology and Infection Medicine Tuebingen, Microbiology/Biotechnology, University of Tuebingen, Auf der Morgenstelle 28, 72076, Tuebingen, Germany.|German Center for Infection Research (DZIF), Partner Site Tuebingen, Tuebingen, Germany.
authors.forename: Evi
authors.initials: E
authors.lastname: Stegmann
authors.affiliation: Interfaculty Institute of Microbiology and Infection Medicine Tuebingen, Microbiology/Biotechnology, University of Tuebingen, Auf der Morgenstelle 28, 72076, Tuebingen, Germany.|German Center for Infection Research (DZIF), Partner Site Tuebingen, Tuebingen, Germany.
authors.forename: Nadine
authors.initials: N
authors.lastname: Ziemert
mesh_terms: D000900:Anti-Bacterial Agents / Q000302:isolation & purification* / Q000494:pharmacology*; D001688:Biological Products / Q000302:isolation & purification* / Q000494:pharmacology*; D055808:Drug Discovery / Q000379:methods* / Q000639:trends
chemical_list: D000900:Anti-Bacterial Agents; D001688:Biological Products