title: [Modern look at pharmacotherapy of osteoarthritis accomplished with cardiovascular disease].
abstract: ABSTR ACTCT Introduction: At present, the main pathogenetic link in the development of OA as atherosclerosis is chronic inflammation, which is based on the activation of pro-inflammatory mediators and disorders of cholesterol metabolism. The aim of the research was to study the efficiency of the use of rosuvastatin in the treatment of patients with osteoarthritis in the combined arterial disease.
  
  
  METHODS
  The study was conducted on the basis of the Poltava Regional Clinical Hospital. N.V. Sklifosovsky and Research Institute of Genetic and immunological bases of pathology and pharmacogenetics higher state educational institution of Ukraine "Ukrainian Medical Dental Academy" (HSEЕU «UMUMCA»). Results of treatment of 30 patients with osteoarthritis and hypertension who received treatment with rosuvastatin.
  
  
  CONCLUSIONS
  It was concluded that the use of rosuvastatin in these patients can reduce pain, improve joint function, reduce disease activity and improve quality of life for patients. Besides rosuvastatin does not affect the level of systolic and diastolic blood pressure and can be used with concomitant hypertension.
authors.affiliation: Высшее Государственное Учебное Заведение Украины «Украинская Медицинская Стоматологическая Академия», Г. Полтава, Украина, ул. Чайковского, дом 7, кв. 32 36002 г. Полтава, Украина. +38 09 91 74 23 16 g_haymenova@mail.ru.
authors.forename: Галина С
authors.initials: ГС
authors.lastname: Хайменова
authors.affiliation: Высшее Государственное Учебное Заведение Украины «Украинская Медицинская Стоматологическая Академия», Г. Полтава, Украина
authors.forename: Марина Ю
authors.initials: МЮ
authors.lastname: Бабанина
authors.affiliation: Высшее Государственное Учебное Заведение Украины «Украинская Медицинская Стоматологическая Академия», Г. Полтава, Украина
authors.forename: Григорий В
authors.initials: ГВ
authors.lastname: Волченко
authors.affiliation: Высшее Государственное Учебное Заведение Украины «Украинская Медицинская Стоматологическая Академия», Г. Полтава, Украина
authors.forename: Максим В
authors.initials: МВ
authors.lastname: Ткаченко
authors.affiliation: Высшее Государственное Учебное Заведение Украины «Украинская Медицинская Стоматологическая Академия», Г. Полтава, Украина
authors.forename: Игорь В
authors.initials: ИВ
authors.lastname: Иваницкий
authors.affiliation: Высшее Государственное Учебное Заведение Украины «Украинская Медицинская Стоматологическая Академия», Г. Полтава, Украина
authors.forename: Вячеслав Н
authors.initials: ВН
authors.lastname: Ждан
mesh_terms: D002318:Cardiovascular Diseases / Q000150:complications / Q000188:drug therapy*; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000627:therapeutic use*; D010003:Osteoarthritis / Q000151:congenital / Q000188:drug therapy*; D011788:Quality of Life; D000068718:Rosuvastatin Calcium / Q000627:therapeutic use*; D014455:Ukraine
chemical_list: D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D000068718:Rosuvastatin Calcium
keywords: hypertension; osteoarthritis; rosuvastatin