title: Neuroendocrine neoplasms and somatostatin receptor subtypes expression.
abstract: Neuroendocrine neoplasms (NENs) show wide spectrum of clinical course - from benign biological potential to recurrences and rapidly progressive disease. Somatostatin analogs that bind to somatostatin receptor are part of the therapy; detection and evaluation of activation of somatostatin receptor subtypes are part of the process of new therapy induction. When using RT-PCR method and immunohistochemistry, it is possible to detect more than two SSTR subtypes in majority or all neuroendo-crine neoplasms regardless tumor origin. Generally with some exceptions, from the viewpoint of tumor grade - apart the site of origin, there is a tendency to decrease the percentage of SSTRs expression; 100% (G1, 2)-85.7% (G3) for SSTR 1; 81.8% (G1, 2)-61.9% (G3) for SSTR 2; 54.5% (G1, 2)-52.4% (G3) for SSTR 3; 9% (G1, 2)-4.8% (G3) for SSTR 5. Different studies indi-cate significant differences in the expression of SSTR 1 and 2A and 2B between NEC G3 small cell type and non-small cell type. Further research on SSTRs expression in NEN could serve as base to development and improvement of somatostatin analogs' pharmacotherapy in patients with unsatisfactory course.
authors.affiliation: Chair and Department of Pathomorphology, Jagiellonian University Medical College. jerzy.hankus@uj.edu.pl.
authors.forename: Jerzy
authors.initials: J
authors.lastname: Hankus
authors.forename: Romana
authors.initials: R
authors.lastname: Tomaszewska
mesh_terms: D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D018358:Neuroendocrine Tumors / Q000235:genetics* / Q000378:metabolism*; D017481:Receptors, Somatostatin / Q000235:genetics* / Q000378:metabolism*
chemical_list: D017481:Receptors, Somatostatin
keywords: NEN; SSTR; expression; neuroendocrine neoplasm; somatostatin; somatostatin receptor