title: LncRNA CCAT2 predicts poor prognosis and regulates growth and metastasis in small cell lung cancer.
abstract: LncRNA colon cancer-associated transcript 2 (CCAT2) was firstly discovered and found overexpressed in colorectal cancer, and identified as is oncogenic lncRNA. However, the significance of CCAT2 in small cell lung cancer (SCLC) remains unclear. The expression of CCAT2 in SCLC tissues and cell lines was detected, and the association between CCAT2 expression and clinicopathological factors was analyzed. Cell proliferation and invasion assays were conducted by using SCLC cell lines transfected with CCAT2-siRNA or NC-siRNA. In our results, CCAT2 expression was elevated in SCLC tissues and cell lines, and correlated with malignant status and poor prognosis of SCLC patients. Furthermore, knockdown of CCAT2 expression effectively suppressed SCLC cell growth and metastasis in vitro. In conclusion, CCAT2 serves as an oncogenic lncRNA, and an independent unfavorable prognostic factor in SCLC patients.
authors.affiliation: Department of Clinical Laboratory, Yantai Yuhuangding Hospital, Yantai, 264000, Shandong province, China.
authors.forename: Shifeng
authors.initials: S
authors.lastname: Chen
authors.affiliation: Department of Clinical Laboratory, Yantai Yuhuangding Hospital, Yantai, 264000, Shandong province, China.
authors.forename: Hong
authors.initials: H
authors.lastname: Wu
authors.affiliation: Department of Clinical Laboratory, Yantai Yuhuangding Hospital, Yantai, 264000, Shandong province, China.
authors.forename: Na
authors.initials: N
authors.lastname: Lv
authors.affiliation: Department of Clinical Laboratory, Yantai Yuhuangding Hospital, Yantai, 264000, Shandong province, China.
authors.forename: Hongling
authors.initials: H
authors.lastname: Wang
authors.affiliation: Department of Clinical Laboratory, Yantai Yuhuangding Hospital, Yantai, 264000, Shandong province, China.
authors.forename: Yushu
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Clinical Laboratory, Yantai Yuhuangding Hospital, Yantai, 264000, Shandong province, China.
authors.forename: Qianqing
authors.initials: Q
authors.lastname: Tang
authors.affiliation: Department of Clinical Laboratory, Yantai Yuhuangding Hospital, Yantai, 264000, Shandong province, China.
authors.forename: Huiyuan
authors.initials: H
authors.lastname: Shao
authors.affiliation: Department of Clinical Laboratory, Yantai Yuhuangding Hospital, Yantai, 264000, Shandong province, China. Electronic address: sunchengming_dr@163.com.
authors.forename: Chengming
authors.initials: C
authors.lastname: Sun
mesh_terms: D045744:Cell Line, Tumor; D049109:Cell Proliferation; D018450:Disease Progression; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D055785:Gene Knockdown Techniques; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics* / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009362:Neoplasm Metastasis; D011379:Prognosis; D016016:Proportional Hazards Models; D062085:RNA, Long Noncoding / Q000235:genetics* / Q000378:metabolism; D055752:Small Cell Lung Carcinoma / Q000235:genetics* / Q000473:pathology*
chemical_list: D062085:RNA, Long Noncoding; C000609264:long non-coding RNA CCAT2, human
keywords: CCAT2; LncRNA; Metastasis; Proliferation; SCLC