title: Impact of CT-apelin and NT-proBNP on identifying non-responders to cardiac resynchronization therapy.
abstract: BACKGROUND
  Assessment of response to cardiac resynchronization therapy (CRT) is essential.
  
  
  OBJECTIVE
  To assess the predictive value of CT-apelin together with NT-proBNP in patients undergoing CRT.
  
  
  METHODS
  Serum CT-apelin and NT-proBNP were measured by ELISA before, and six months after CRT. Primary endpoint was non-response (<4% increase in LVEF) after six months.
  
  
  RESULTS
  From 81 patients, 15 proved to be non-responders. Six-month CT-apelin was superior compared to NT-proBNP in identifying non-responders by multivariate ROC (CT-apelin: p = 0.01, NT-proBNP: p = 0.13) and by logistic regression (CT-apelin: p = 0.01, NT-proBNP: p = 0.41) analyses.
  
  
  CONCLUSIONS
  Six-month CT-apelin might be a valuable novel biomarker in identifying non-responders to CRT that was superior to NT-proBNP.
authors.affiliation: a Heart and Vascular Center Semmelweis University , Budapest , Hungary.
authors.forename: Annamária
authors.initials: A
authors.lastname: Kosztin
authors.affiliation: a Heart and Vascular Center Semmelweis University , Budapest , Hungary.
authors.forename: Gábor
authors.initials: G
authors.lastname: Széplaki
authors.affiliation: a Heart and Vascular Center Semmelweis University , Budapest , Hungary.
authors.forename: Attila
authors.initials: A
authors.lastname: Kovács
authors.affiliation: a Heart and Vascular Center Semmelweis University , Budapest , Hungary.|b National Heart and Lung Institute Imperial College , London , United Kingdom.
authors.forename: Gábor
authors.initials: G
authors.lastname: Földes
authors.affiliation: c Heart Institute, Medical School, University of Pécs , Pécs , Hungary.
authors.forename: István
authors.initials: I
authors.lastname: Szokodi
authors.affiliation: a Heart and Vascular Center Semmelweis University , Budapest , Hungary.
authors.forename: Klaudia
authors.initials: K
authors.lastname: Vivien Nagy
authors.affiliation: a Heart and Vascular Center Semmelweis University , Budapest , Hungary.|e University of Rochester, Medical Center , Rochester , NY , USA.
authors.forename: Valentina
authors.initials: V
authors.lastname: Kutyifa
authors.affiliation: a Heart and Vascular Center Semmelweis University , Budapest , Hungary.
authors.forename: Éva
authors.initials: É
authors.lastname: Fórizs
authors.affiliation: a Heart and Vascular Center Semmelweis University , Budapest , Hungary.
authors.forename: Eszter M
authors.initials: EM
authors.lastname: Végh
authors.affiliation: a Heart and Vascular Center Semmelweis University , Budapest , Hungary.
authors.forename: László
authors.initials: L
authors.lastname: Gellér
authors.affiliation: a Heart and Vascular Center Semmelweis University , Budapest , Hungary.
authors.forename: Dávid
authors.initials: D
authors.lastname: Becker
authors.affiliation: a Heart and Vascular Center Semmelweis University , Budapest , Hungary.|d Heart Center , Balatonfüred , Hungary.
authors.forename: Dániel
authors.initials: D
authors.lastname: Aradi
authors.affiliation: a Heart and Vascular Center Semmelweis University , Budapest , Hungary.
authors.forename: Béla
authors.initials: B
authors.lastname: Merkely
mesh_terms: D000368:Aged; D000073861:Apelin; D015415:Biomarkers / Q000097:blood; D058406:Cardiac Resynchronization Therapy; D005260:Female; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000097:blood*; D008297:Male; D008875:Middle Aged; D020097:Natriuretic Peptide, Brain / Q000097:blood*; D010446:Peptide Fragments / Q000097:blood*; D011237:Predictive Value of Tests; D012044:Regression Analysis; D016896:Treatment Outcome
chemical_list: C115436:APLN protein, human; D000073861:Apelin; D015415:Biomarkers; D036341:Intercellular Signaling Peptides and Proteins; D010446:Peptide Fragments; C109794:pro-brain natriuretic peptide (1-76); D020097:Natriuretic Peptide, Brain
keywords: CRT responder; Cardiovascular disease; NT-proBNP; apelin; renal disease