title: Clinical Features of Respiratory Viral Infections Among Inpatients at a Major US Tertiary Care Hospital.
abstract: Respiratory viral illnesses (RVI) are reliably diagnosed by respiratory viral panel using polymerase chain reaction (RVP-PCR); however, owing to the scant data, clinical presentation alone is unreliable in establishing viral etiology. The primary objective of this study was to characterize signs and symptoms of RVI among inpatients in a major tertiary care hospital.
  
  
  
  Between 2013 and 2015, adult inpatients with RVI undergoing RVP-PCR were prospectively enrolled in our study. Clinical data were collected by interviews and electronic medical record reviews. Data analysis was performed using χ(2) testing, analysis of variance for continuous variables, and logistic regression modeling.
  
  
  
  Of 421 patients analyzed, 175 (41.7%) had a positive RVP-PCR. Patients were evenly matched at baseline except for renal disease. Multivariate logistic regression modeling demonstrated the following positive correlations: positive RVP-PCR with renal disease (odds ratio [OR] 2.08), cough (OR 2.28), and wheezing (OR 1.8); influenza with cough (OR 5.04), and renal disease (OR 2.17); metapneumovirus with age older than 65 (OR 3.24); respiratory syncytial viruses with wheezing (OR 3.42) and immunosuppression (OR 3.11); and parainfluenza with smoking (OR 3.16). Negative correlations included influenza with anosmia (OR 0.41); rhinovirus/enterovirus with feeling confined to bed (OR 0.3); metapneumovirus with smoking (OR 0.29); and parainfluenza with male sex (OR 0.22).
  
  
  
  In this descriptive study, we noted specific viral associations with clinical signs and symptoms among 421 inpatients with RVIs. With increasing RVP-PCR use, studies similar to ours may be able to better define the clinical presentation of RVIs and lead to evidence-based, clinical presentation-guided diagnostic and management algorithms.
authors.affiliation: From the Division of Infectious Diseases, the Department of Occupational Medicine, Epidemiology, and Prevention, and the Department of Internal Medicine, North Shore Long Island Jewish Hofstra School of Medicine, Manhasset and Great Neck, New York, War Memorial Hospital, Sault Sainte Marie, Michigan, New York University Lutheran Medical Center, Brooklyn, and Mercy Hospital, St Louis, Missouri.
authors.forename: Prashant
authors.initials: P
authors.lastname: Malhotra
authors.affiliation: From the Division of Infectious Diseases, the Department of Occupational Medicine, Epidemiology, and Prevention, and the Department of Internal Medicine, North Shore Long Island Jewish Hofstra School of Medicine, Manhasset and Great Neck, New York, War Memorial Hospital, Sault Sainte Marie, Michigan, New York University Lutheran Medical Center, Brooklyn, and Mercy Hospital, St Louis, Missouri.
authors.forename: Arthur
authors.initials: A
authors.lastname: Luka
authors.affiliation: From the Division of Infectious Diseases, the Department of Occupational Medicine, Epidemiology, and Prevention, and the Department of Internal Medicine, North Shore Long Island Jewish Hofstra School of Medicine, Manhasset and Great Neck, New York, War Memorial Hospital, Sault Sainte Marie, Michigan, New York University Lutheran Medical Center, Brooklyn, and Mercy Hospital, St Louis, Missouri.
authors.forename: Carla S
authors.initials: CS
authors.lastname: McWilliams
authors.affiliation: From the Division of Infectious Diseases, the Department of Occupational Medicine, Epidemiology, and Prevention, and the Department of Internal Medicine, North Shore Long Island Jewish Hofstra School of Medicine, Manhasset and Great Neck, New York, War Memorial Hospital, Sault Sainte Marie, Michigan, New York University Lutheran Medical Center, Brooklyn, and Mercy Hospital, St Louis, Missouri.
authors.forename: Kaitlin G
authors.initials: KG
authors.lastname: Poeth
authors.affiliation: From the Division of Infectious Diseases, the Department of Occupational Medicine, Epidemiology, and Prevention, and the Department of Internal Medicine, North Shore Long Island Jewish Hofstra School of Medicine, Manhasset and Great Neck, New York, War Memorial Hospital, Sault Sainte Marie, Michigan, New York University Lutheran Medical Center, Brooklyn, and Mercy Hospital, St Louis, Missouri.
authors.forename: Rebecca
authors.initials: R
authors.lastname: Schwartz
authors.affiliation: From the Division of Infectious Diseases, the Department of Occupational Medicine, Epidemiology, and Prevention, and the Department of Internal Medicine, North Shore Long Island Jewish Hofstra School of Medicine, Manhasset and Great Neck, New York, War Memorial Hospital, Sault Sainte Marie, Michigan, New York University Lutheran Medical Center, Brooklyn, and Mercy Hospital, St Louis, Missouri.
authors.forename: Mohammed
authors.initials: M
authors.lastname: Elfekey
authors.affiliation: From the Division of Infectious Diseases, the Department of Occupational Medicine, Epidemiology, and Prevention, and the Department of Internal Medicine, North Shore Long Island Jewish Hofstra School of Medicine, Manhasset and Great Neck, New York, War Memorial Hospital, Sault Sainte Marie, Michigan, New York University Lutheran Medical Center, Brooklyn, and Mercy Hospital, St Louis, Missouri.
authors.forename: Sandy
authors.initials: S
authors.lastname: Balwan
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D003371:Cough / Q000209:etiology / Q000821:virology; D005260:Female; D006801:Humans; D007251:Influenza, Human / Q000150:complications / Q000175:diagnosis / Q000473:pathology; D008297:Male; D008875:Middle Aged; D012135:Respiratory Sounds / Q000209:etiology; D012141:Respiratory Tract Infections / Q000150:complications / Q000175:diagnosis / Q000473:pathology* / Q000821:virology; D062606:Tertiary Care Centers / Q000706:statistics & numerical data*; D055815:Young Adult