title: The incidence of sexually acquired reactive arthritis: a systematic literature review.
abstract: Reactive arthritis (ReA) is an inflammatory spondyloarthritis occurring after infection at a distant site. Chlamydia trachomatis is proposed to be the most common cause of ReA, yet the incidence of sexually acquired ReA (SARA) has not been well established. We therefore carried out a systematic literature review to collate and critically evaluate the published evidence regarding the incidence of SARA. MEDLINE and EMBASE databases were searched using free-text and MeSH terms relating to infection and ReA. The title and abstract of articles returned were screened independently by two reviewers and potentially relevant articles assessed in full. Data was extracted from relevant articles and a risk of bias assessment carried out using a validated tool. Heterogeneity of study methodology and results precluded meta-analysis. The search yielded a total of 11,680 articles, and a further 17 were identified from review articles. After screening, 55 papers were assessed in full, from which 3 met the relevant inclusion criteria for the review. The studies reported an incidence of SARA of 3.0-8.1 % and were found to be of low to moderate quality. More studies are required to address the lack of data regarding the incidence of SARA. Specific and sensitive classification criteria must be developed in order for consistent classification and valid conclusions to be drawn. In clinical practice, it is recommended clinicians discuss the possibility of ReA developing at the time of STI diagnosis and to encourage patients to return if they experience any relevant symptoms.
authors.affiliation: School of Biological Sciences, Victoria University of Wellington, Wellington, New Zealand. hayley.denison@vuw.ac.nz.
authors.forename: Hayley J
authors.initials: HJ
authors.lastname: Denison
authors.affiliation: MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton, United Kingdom.
authors.forename: Elizabeth M
authors.initials: EM
authors.lastname: Curtis
authors.affiliation: MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton, United Kingdom.
authors.forename: Michael A
authors.initials: MA
authors.lastname: Clynes
authors.affiliation: College of Health, Massey University, Wellington, New Zealand.
authors.forename: Collette
authors.initials: C
authors.lastname: Bromhead
authors.affiliation: School of Biological Sciences, Victoria University of Wellington, Wellington, New Zealand.|MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton, United Kingdom.
authors.forename: Elaine M
authors.initials: EM
authors.lastname: Dennison
authors.affiliation: Rehabilitation Teaching and Research Unit, Department of Medicine, University of Otago Wellington, Wellington, New Zealand.
authors.forename: Rebecca
authors.initials: R
authors.lastname: Grainger
mesh_terms: D016918:Arthritis, Reactive / Q000453:epidemiology*; D002690:Chlamydia Infections / Q000453:epidemiology*; D006801:Humans; D015994:Incidence; D000091402:Prohibitins; D012749:Sexually Transmitted Diseases / Q000453:epidemiology*
keywords: Incidence; Reactive arthritis < rheumatic diseases; Sexually transmitted infections; Systematic review