title: Linking cancer-induced Nlrp3 inflammasome activation to efficient NK cell-mediated immunosurveillance.
abstract: We have recently demonstrated that the Nlrp3 inflammasome can detect the presence of colorectal cancer (CRC) metastatic growth in the liver and limit its growth. Inflammasome signaling primed natural killer (NK) cells through Interleukin (IL)-18 and activated their ability to trigger FasL-induced apoptosis of the tumor.
authors.affiliation: Department of Biochemistry, McGill University , Montreal, Quebec, Canada.
authors.forename: Maryse
authors.initials: M
authors.lastname: Dagenais
authors.affiliation: Department of Biochemistry, McGill University, Montreal, Quebec, Canada; Department of Medicine, McGill University, Montreal, Quebec, Canada; Department of Microbiology and Immunology McGill University, Montreal, Quebec, Canada.
authors.forename: Maya
authors.initials: M
authors.lastname: Saleh
keywords: Apoptosis; Fas; NK cells; Nlrp3 inflammasome; cancer; immunosurveillance; immunotherapy; innate immunity