title: Circulating Omentin-1 and Chronic Painful Temporomandibular Disorders.
abstract: OBJECTIVE
  To investigate the relationship between omentin-1 levels and painful temporomandibular disorders (TMD).
  
  
  METHODS
  In a case-control design, chronic painful TMD cases (n = 90) and TMD-free controls (n = 54) were selected from participants in the multisite OPPERA study (Orofacial Pain: Prospective Evaluation and Risk Assessment). Painful TMD case status was determined by examination using established Research Diagnostic Criteria for TMD (RDC/TMD). Levels of omentin-1 in stored blood plasma samples were measured by using an enzyme linked immunosorbent assay. Binary logistic regression was used to calculate the odds ratios (ORs) and 95% confidence limits (CLs) for the association between omentin-1 and painful TMD. Models were adjusted for study site, age, sex, and body mass index.
  
  
  RESULTS
  The unadjusted association between omentin-1 and chronic painful TMD was statistically nonsignificant (P = .072). Following adjustment for covariates, odds of TMD pain decreased 36% per standard deviation increase in circulating omentin-1 (adjusted OR = 0.64; 95% CL: 0.43, 0.96; P = .031).
  
  
  CONCLUSIONS
  Circulating levels of omentin-1 were significantly lower in painful TMD cases than controls, suggesting that TMD pain is mediated by inflammatory pathways.
authors.forename: Jennifer B
authors.initials: JB
authors.lastname: Harmon
authors.forename: Anne E
authors.initials: AE
authors.lastname: Sanders
authors.forename: Rebecca S
authors.initials: RS
authors.lastname: Wilder
authors.forename: Greg K
authors.initials: GK
authors.lastname: Essick
authors.forename: Gary D
authors.initials: GD
authors.lastname: Slade
authors.forename: Jane E
authors.initials: JE
authors.lastname: Hartung
authors.forename: Andrea G
authors.initials: AG
authors.lastname: Nackley
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D001416:Back Pain / Q000097:blood; D015992:Body Mass Index; D016022:Case-Control Studies; D002908:Chronic Disease; D016207:Cytokines / Q000097:blood*; D005157:Facial Pain / Q000097:blood; D005260:Female; D058851:GPI-Linked Proteins / Q000097:blood; D006261:Headache / Q000097:blood; D006801:Humans; D037102:Lectins / Q000097:blood*; D008297:Male; D010147:Pain Measurement / Q000379:methods; D012737:Sex Factors; D013705:Temporomandibular Joint Disorders / Q000097:blood*; D055815:Young Adult
chemical_list: D016207:Cytokines; D058851:GPI-Linked Proteins; C432397:ITLN1 protein, human; D037102:Lectins