title: Molecular Mechanisms of Cutaneous Inflammatory Disorder: Atopic Dermatitis.
abstract: Atopic dermatitis (AD) is a multifactorial inflammatory skin disease resulting from interactions between genetic susceptibility and environmental factors. The pathogenesis of AD is poorly understood, and the treatment of recalcitrant AD is still challenging. There is accumulating evidence for new gene polymorphisms related to the epidermal barrier function and innate and adaptive immunity in patients with AD. Newly-found T cells and dendritic cell subsets, cytokines, chemokines and signaling pathways have extended our understanding of the molecular pathomechanism underlying AD. Genetic changes caused by environmental factors have been shown to contribute to the pathogenesis of AD. We herein present a review of the genetics, epigenetics, barrier dysfunction and immunological abnormalities in AD with a focus on updated molecular biology.
authors.affiliation: Department of Dermatology, St. Paul's Hospital, College of Medicine, The Catholic University of Korea, Seoul 02559, Korea. mdkjeun@naver.com.
authors.forename: Jung Eun
authors.initials: JE
authors.lastname: Kim
authors.affiliation: Department of Dermatology, Yeouido St. Mary's Hospital, College of Medicine, The Catholic University of Korea, 62 Yeouido-dong, Yeongdeungpo-gu, Seoul 07345, Korea. rodmann@nate.com.
authors.forename: Jong Sic
authors.initials: JS
authors.lastname: Kim
authors.affiliation: Department of Life Science, SookmyungWomen's University, Seoul 140-742, Korea. cdhkor@sookmyung.ac.kr.
authors.forename: Dae Ho
authors.initials: DH
authors.lastname: Cho
authors.affiliation: Department of Dermatology, Yeouido St. Mary's Hospital, College of Medicine, The Catholic University of Korea, 62 Yeouido-dong, Yeongdeungpo-gu, Seoul 07345, Korea. hjpark@catholic.ac.kr.
authors.forename: Hyun Jeong
authors.initials: HJ
authors.lastname: Park
mesh_terms: D000818:Animals; D003876:Dermatitis, Atopic / Q000503:physiopathology*; D006801:Humans; D007249:Inflammation / Q000503:physiopathology*
keywords: atopic dermatitis; barrier; epigenomics; genetics; immunologic abnormalities