title: Autologous Bone Marrow Transplantation Followed by Involved Field Radiotherapy in Patients with Relapsed or Refractory Hodgkin's Disease.
abstract: Twenty-six patients with refractory or relapsed Hodgkin's disease were treated with high dose cyclophosphamide, BCNU, etoposide, and thiotepa followed by autologous hematopoietic stem cell rescue. Involved field radiotherapy was given following hematologic recovery in selected patients. The overall response rate to the high dose chemotherapy was 69% with 34% complete responses. Following radiotherapy, the complete response rate increased to 50%. The predicted disease-free survival at two years is 22%. Toxicity with this regimen was significant, with five patients dying as a result of transplant related complications. We conclude that the addition of thiotepa to the standard CBV regimen did not result in improved therapeutic efficacy and possibly contributed significantly to the toxicity of the treatment.
authors.affiliation: a The Section of Hematology/Oncology and the Department of Radiation Oncology, The University of Chicago Medical Center, Chicago, Illinois, USA.
authors.forename: J A
authors.initials: JA
authors.lastname: Moormeier
authors.affiliation: a The Section of Hematology/Oncology and the Department of Radiation Oncology, The University of Chicago Medical Center, Chicago, Illinois, USA.
authors.forename: S F
authors.initials: SF
authors.lastname: Williams
authors.affiliation: a The Section of Hematology/Oncology and the Department of Radiation Oncology, The University of Chicago Medical Center, Chicago, Illinois, USA.
authors.forename: L S
authors.initials: LS
authors.lastname: Kaminer
authors.affiliation: a The Section of Hematology/Oncology and the Department of Radiation Oncology, The University of Chicago Medical Center, Chicago, Illinois, USA.
authors.forename: E D
authors.initials: ED
authors.lastname: Ellis
authors.affiliation: a The Section of Hematology/Oncology and the Department of Radiation Oncology, The University of Chicago Medical Center, Chicago, Illinois, USA.
authors.forename: M
authors.initials: M
authors.lastname: Garner
authors.affiliation: a The Section of Hematology/Oncology and the Department of Radiation Oncology, The University of Chicago Medical Center, Chicago, Illinois, USA.
authors.forename: R
authors.initials: R
authors.lastname: Farah
authors.affiliation: a The Section of Hematology/Oncology and the Department of Radiation Oncology, The University of Chicago Medical Center, Chicago, Illinois, USA.
authors.forename: R R
authors.initials: RR
authors.lastname: Weichselbaum
authors.affiliation: a The Section of Hematology/Oncology and the Department of Radiation Oncology, The University of Chicago Medical Center, Chicago, Illinois, USA.
authors.forename: J D
authors.initials: JD
authors.lastname: Bitran
keywords: Autologous bone marrow transplantation; Hodgkin's disease; thiotepa