title: The protective cardiac effects of Β-myrcene after global cerebral ıschemia/reperfusion in C57BL/J6 mouse.
abstract: OBJECTIVE
  To investigate the protective effect of β-myrcene (MYR) on oxidative and histological damage in mice heart tissue caused global cerebral ischemia/reperfusion (IR) in C57BL/J6 mice.
  
  
  METHODS
  Animals(n=40) were randomly divided into four groups: (1)control, (2)IR, (3)MYR and (4)MYR+IR. The control group was received 0.1% carboxymethyl cellulose as a vehicle following a medial incision without carotid occlusion. In the IR group, the bilateral carotid arteries were clipped for 15min, and treated with the vehicle intraperitoneally(ip) for 10 days. MYR (200mg/kg) was received dissolved in 0.1%CMC for 10 days. In the MYR+IR group, the IR model was applied exactly as in the IR group, and then they were treated with MYR 10 days.
  
  
  RESULTS
  The cerebral IR caused oxidative damage (increase TBARS, decrease antioxidant parameters). Treatment of MYR was increased in GSH,GPx,CAT,SOD activity while TBARS level was decreased. In addition, degenerative changes in I/R group heart tissue were ameliorated by MYR administration.
  The administration of β-myrcene protects oxidative and histological damage in the heart tissue after global ischemia-reperfusion and may be useful safe alternative treatment for cardiac tissue after ischemic stroke.
authors.affiliation: Assistant Professor, Department of Pharmacology and Toxicology, Faculty of Veterinary, University of Firat, Elazig, Turkey. Acquisition of data, manuscript writing.
authors.forename: Gul Baykalir
authors.initials: GB
authors.lastname: Burcu
authors.affiliation: Professor, Department of Medical Pharmacology, Faculty of Medicine, University of Inonu, Malatya, Turkey. Design of the study, manuscript writing, carry out the study.
authors.forename: Ciftci
authors.initials: C
authors.lastname: Osman
authors.affiliation: Assistant Professor, Department of Histology and Embryology, Faculty of Medicine, University of Inonu, Malatya, Turkey. Histological examinations.
authors.forename: Cetin
authors.initials: C
authors.lastname: Aslı
authors.affiliation: Professor, Department of Brain and Neurosurgery, Faculty of Medicine, University of Inonu, Malatya, Turkey. Design of the study.
authors.forename: Oztanir Mustafa
authors.initials: OM
authors.lastname: Namik
authors.affiliation: PhD, Department of Pharmaceutical Toxicology, Faculty of Pharmacy, University of Inonu, Malatya, Turkey. Biochemical experiments.
authors.forename: Basak Türkmen
authors.initials: BT
authors.lastname: Neşe
mesh_terms: D000080462:Acyclic Monoterpenes; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D002545:Brain Ischemia / Q000150:complications*; D002316:Cardiotonic Agents / Q000494:pharmacology*; D002374:Catalase / Q000378:metabolism; D005978:Glutathione / Q000378:metabolism; D005979:Glutathione Peroxidase / Q000378:metabolism; D006321:Heart / Q000187:drug effects*; D008297:Male; D008810:Mice, Inbred C57BL; D023421:Models, Animal; D039821:Monoterpenes / Q000494:pharmacology*; D009206:Myocardium / Q000378:metabolism / Q000473:pathology; D018384:Oxidative Stress / Q000187:drug effects; D011897:Random Allocation; D015427:Reperfusion Injury / Q000150:complications*; D013482:Superoxide Dismutase / Q000378:metabolism; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism
chemical_list: D000080462:Acyclic Monoterpenes; D000975:Antioxidants; D002316:Cardiotonic Agents; D039821:Monoterpenes; D017392:Thiobarbituric Acid Reactive Substances; C008574:beta-myrcene; D002374:Catalase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D005978:Glutathione