title: Long-term Diet and Biomarker Changes after a Short-term Intervention among Hispanic Breast Cancer Survivors: The ¡Cocinar Para Su Salud! Randomized Controlled Trial.
abstract: Among Hispanic breast cancer survivors, we examined the long-term effects of a short-term culturally based dietary intervention on increasing fruits/vegetables (F/V), decreasing fat, and changing biomarkers associated with breast cancer recurrence risk.
  
  
  
  Spanish-speaking women (n = 70) with a history of stage 0-III breast cancer who completed treatment were randomized to ¡Cocinar Para Su Salud! (n = 34), a culturally based 9-session program (24 hours over 12 weeks, including nutrition education, cooking classes, and food-shopping field trips), or a control group (n = 36, written dietary recommendations for breast cancer survivors). Diet recalls, fasting blood, and anthropometric measures were collected at baseline, 6, and 12 months. We report changes between groups at 12 months in dietary intake and biomarkers using 2-sample Wilcoxon t tests and generalized estimating equation (GEE) models.
  
  
  
  At 12 months, the intervention group compared with the control group reported higher increases in mean daily F/V servings (total: +2.0 vs. -0.4; P < 0.01), and nonsignificant decreases in the percentage of calories from fat (-2.2% vs. -1.1%; P = 0.69) and weight (-2.6 kg vs. -1.5 kg; P = 0.56). Compared with controls, participants in the intervention group had higher increases in plasma lutein (+20.4% vs. -11.5%; P < 0.01), and borderline significant increases in global DNA methylation (+0.8% vs. -0.5%; P = 0.06).
  
  
  
  The short-term ¡Cocinar Para Su Salud! program was effective at increasing long-term F/V intake in Hispanic breast cancer survivors and changed biomarkers associated with breast cancer recurrence risk.
  
  
  
  It is possible for short-term behavioral interventions to have long-term effects on behaviors and biomarkers in minority cancer patient populations. Results can inform future study designs. Cancer Epidemiol Biomarkers Prev; 25(11); 1491-502. ©2016 AACR.
authors.affiliation: Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York. hg2120@columbia.edu.|Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, New York.
authors.forename: Heather
authors.initials: H
authors.lastname: Greenlee
authors.affiliation: Cook for Your Life, New York, New York.
authors.forename: Ann
authors.initials: A
authors.lastname: Ogden Gaffney
authors.affiliation: Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, New York.|Department of Health and Behavior Studies, Teachers College, Columbia University, New York, New York.
authors.forename: A Corina
authors.initials: AC
authors.lastname: Aycinena
authors.affiliation: Department of Health and Behavior Studies, Teachers College, Columbia University, New York, New York.
authors.forename: Pam
authors.initials: P
authors.lastname: Koch
authors.affiliation: Department of Health and Behavior Studies, Teachers College, Columbia University, New York, New York.
authors.forename: Isobel
authors.initials: I
authors.lastname: Contento
authors.affiliation: Irving Institute for Clinical and Translational Research, Columbia University, New York, New York.
authors.forename: Wahida
authors.initials: W
authors.lastname: Karmally
authors.affiliation: Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York.
authors.forename: John M
authors.initials: JM
authors.lastname: Richardson
authors.affiliation: Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York.
authors.forename: Zaixing
authors.initials: Z
authors.lastname: Shi
authors.affiliation: Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, New York.
authors.forename: Emerson
authors.initials: E
authors.lastname: Lim
authors.affiliation: Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, New York.|Department of Biostatistics, Mailman School of Public Health, Columbia University, New York, New York.
authors.forename: Wei-Yann
authors.initials: WY
authors.lastname: Tsai
authors.affiliation: Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, New York.|Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, New York.
authors.forename: Regina M
authors.initials: RM
authors.lastname: Santella
authors.affiliation: Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, New York.
authors.forename: William S
authors.initials: WS
authors.lastname: Blaner
authors.affiliation: Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, New York.
authors.forename: Robin D
authors.initials: RD
authors.lastname: Clugston
authors.affiliation: Irving Institute for Clinical and Translational Research, Columbia University, New York, New York.
authors.forename: Serge
authors.initials: S
authors.lastname: Cremers
authors.affiliation: Irving Institute for Clinical and Translational Research, Columbia University, New York, New York.
authors.forename: Susan
authors.initials: S
authors.lastname: Pollak
authors.affiliation: Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, New York.
authors.forename: Iryna
authors.initials: I
authors.lastname: Sirosh
authors.affiliation: Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York.|Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, New York.|Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, New York.
authors.forename: Katherine D
authors.initials: KD
authors.lastname: Crew
authors.affiliation: Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, New York.|Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, New York.
authors.forename: Matthew
authors.initials: M
authors.lastname: Maurer
authors.affiliation: Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, New York.|Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, New York.
authors.forename: Kevin
authors.initials: K
authors.lastname: Kalinsky
authors.affiliation: Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York.|Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, New York.|Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, New York.
authors.forename: Dawn L
authors.initials: DL
authors.lastname: Hershman
mesh_terms: D015415:Biomarkers / Q000097:blood; D001943:Breast Neoplasms; D000073116:Cancer Survivors; D018752:Diet, Fat-Restricted; D005260:Female; D005638:Fruit; D006630:Hispanic or Latino; D006801:Humans; D009364:Neoplasm Recurrence, Local / Q000097:blood / Q000178:diet therapy / Q000517:prevention & control*; D013995:Time; D014675:Vegetables
chemical_list: D015415:Biomarkers