title: Chemical constituents of Narcissus tazetta var. chinensis and their antioxidant activities.
abstract: Two new flavan derivatives tazettones C-D (1-2), one new β-coumaranone (tazettone E, 3), one new flavan (tazettone F, 4), and one new phenylpropanoid (tazettone G, 5), together with six known flavonoids (6-11), were isolated from the bulbs of Narcissus tazetta var. chinensis Roem. Their structures were elucidated by spectroscopic analysis. In addition, the structures of 1-3 were confirmed by single crystal X-ray diffraction. All isolated compounds were tested for antioxidant activity by Cell Counting Kit-8 (CCK-8) assay. Compounds 6-8 and 10-11 exhibited potent antioxidant activity against H2O2-induced impairment in human SH-SY5Y neuroblastoma cells at tested concentrations.
authors.affiliation: Department of Phytochemistry, School of Pharmacy, Second Military Medical University, Shanghai 200433, China.
authors.forename: Ka-Li
authors.initials: KL
authors.lastname: Fu
authors.affiliation: School of Pharmaceutical Science and Yunnan Key Laboratory of Pharmacology of Natural Products, Kunming Medical University, Kunming 650500, Yunnan, China.
authors.forename: Xian
authors.initials: X
authors.lastname: Li
authors.affiliation: Department of Phytochemistry, School of Pharmacy, Second Military Medical University, Shanghai 200433, China.
authors.forename: Ji
authors.initials: J
authors.lastname: Ye
authors.affiliation: Department of Phytochemistry, School of Pharmacy, Second Military Medical University, Shanghai 200433, China.
authors.forename: Lu
authors.initials: L
authors.lastname: Lu
authors.affiliation: Department of Phytochemistry, School of Pharmacy, Second Military Medical University, Shanghai 200433, China.
authors.forename: Xi-Ke
authors.initials: XK
authors.lastname: Xu
authors.affiliation: Department of Phytochemistry, School of Pharmacy, Second Military Medical University, Shanghai 200433, China.
authors.forename: Hui-Liang
authors.initials: HL
authors.lastname: Li
authors.affiliation: Department of Phytochemistry, School of Pharmacy, Second Military Medical University, Shanghai 200433, China; Shanghai Institute of Pharmaceutical Industry, Shanghai 200400, China. Electronic address: wdzhangy@hotmail.com.
authors.forename: Wei-Dong
authors.initials: WD
authors.lastname: Zhang
authors.affiliation: Department of Phytochemistry, School of Pharmacy, Second Military Medical University, Shanghai 200433, China. Electronic address: shenyunheng@hotmail.com.
authors.forename: Yun-Heng
authors.initials: YH
authors.lastname: Shen
mesh_terms: D000975:Antioxidants / Q000737:chemistry* / Q000302:isolation & purification; D045744:Cell Line, Tumor; D044950:Flavanones / Q000737:chemistry* / Q000302:isolation & purification; D006801:Humans; D006861:Hydrogen Peroxide; D015394:Molecular Structure; D031427:Narcissus / Q000737:chemistry*; D018517:Plant Roots / Q000737:chemistry*
chemical_list: D000975:Antioxidants; D044950:Flavanones; D006861:Hydrogen Peroxide
keywords: Amaryllidaceae; Antioxidant activity; Flavan; Narcissus tazetta var. chinensis; SH-SY5Y cell