title: Inverse association between carbohydrate consumption and plasma adropin concentrations in humans.
abstract: The role of metabolic condition and diet in regulating circulating levels of adropin, a peptide hormone linked to cardiometabolic control, is not well understood. In this study, weight loss and diet effects on plasma adropin concentrations were examined.
  
  
  
  This report includes data from (1) a weight loss trial, (2) an evaluation of acute exercise effects on mixed-meal (60% kcal from carbohydrates) tolerance test responses, and (3) a meta-analysis to determine normal fasting adropin concentrations.
  
  
  
  Distribution of plasma adropin concentrations exhibited positive skew and kurtosis. The effect of weight loss on plasma adropin concentrations was dependent on baseline plasma adropin concentrations, with an inverse association between baseline and a decline in concentrations after weight loss (Spearman's ρ = -0.575; P < 0.001). When ranked by baseline plasma adropin concentrations, only values in the upper quartile declined with weight loss. Plasma adropin concentrations under the main area of the bell curve correlated negatively with habitual carbohydrate intake and plasma lipids. There was a negative correlation between baseline values and a transient decline in plasma adropin during the mixed-meal tolerance test.
  
  
  
  Plasma adropin concentrations in humans are sensitive to dietary macronutrients, perhaps due to habitual consumption of carbohydrate-rich diets suppressing circulating levels. Very high adropin levels may indicate cardiometabolic conditions sensitive to weight loss.
authors.affiliation: Department of Pharmacology and Physiology, Saint Louis University School of Medicine, St. Louis, Missouri, USA.
authors.forename: Joseph R
authors.initials: JR
authors.lastname: Stevens
authors.affiliation: Department of Nutrition and Exercise Physiology, University of Missouri, Columbia, Missouri, USA.
authors.forename: Monica L
authors.initials: ML
authors.lastname: Kearney
authors.affiliation: Department of Medicine, New York Obesity Research Center, New York, New York, USA.|Institute of Human Nutrition, Columbia University, New York, New York, USA.
authors.forename: Marie-Pierre
authors.initials: MP
authors.lastname: St-Onge
authors.affiliation: Department of Molecular Biosciences, School of Veterinary Medicine, University of California-Davis, Davis, California, USA.|Department of Nutrition, School of Medicine, University of California-Davis, Davis, California, USA.
authors.forename: Kimber L
authors.initials: KL
authors.lastname: Stanhope
authors.affiliation: Department of Molecular Biosciences, School of Veterinary Medicine, University of California-Davis, Davis, California, USA.|Department of Nutrition, School of Medicine, University of California-Davis, Davis, California, USA.
authors.forename: Peter J
authors.initials: PJ
authors.lastname: Havel
authors.affiliation: Department of Nutrition and Exercise Physiology, University of Missouri, Columbia, Missouri, USA.
authors.forename: Jill A
authors.initials: JA
authors.lastname: Kanaley
authors.affiliation: Department of Molecular and Integrative Physiology, University of Kansas Medical Center, Kansas City, Kansas, USA.
authors.forename: John P
authors.initials: JP
authors.lastname: Thyfault
authors.affiliation: Department of Nutrition and Dietetics, Doisy College of Health Sciences of Saint Louis University, St. Louis, Missouri, USA.
authors.forename: Edward P
authors.initials: EP
authors.lastname: Weiss
authors.affiliation: Department of Pharmacology and Physiology, Saint Louis University School of Medicine, St. Louis, Missouri, USA.
authors.forename: Andrew A
authors.initials: AA
authors.lastname: Butler
mesh_terms: D001786:Blood Glucose / Q000378:metabolism; D001798:Blood Proteins; D004040:Dietary Carbohydrates / Q000008:administration & dosage*; D004041:Dietary Fats / Q000008:administration & dosage; D005215:Fasting / Q000097:blood; D005260:Female; D005518:Food Preferences / Q000502:physiology*; D006801:Humans; D007333:Insulin Resistance; D036341:Intercellular Signaling Peptides and Proteins; D008297:Male; D010455:Peptides / Q000097:blood*
chemical_list: D001786:Blood Glucose; D001798:Blood Proteins; D004040:Dietary Carbohydrates; D004041:Dietary Fats; C568440:Enho protein, human; D036341:Intercellular Signaling Peptides and Proteins; D010455:Peptides