title: Transplantation.
abstract: Despite improvement in median life expectancy and overall health, some children with cystic fibrosis (CF) progress to end-stage lung or liver disease and become candidates for transplant. Transplants for children with CF hold the promise to extend and improve the quality of life, but barriers to successful long-term outcomes include shortage of suitable donor organs; potential complications from the surgical procedure and immunosuppressants; risk of rejection and infection; and the need for lifelong, strict adherence to a complex medical regimen. This article reviews the indications and complications of lung and liver transplantation in children with CF.
authors.affiliation: Department of Pediatrics, Washington University in St. Louis, Campus Box 8116, 660 South Euclid Avenue, St Louis, MO 63110, USA. Electronic address: faro_a@kids.wustl.edu.
authors.forename: Albert
authors.initials: A
authors.lastname: Faro
authors.affiliation: Department of Pediatrics, Washington University in St. Louis, Campus Box 8116, 660 South Euclid Avenue, St Louis, MO 63110, USA.
authors.forename: Alexander
authors.initials: A
authors.lastname: Weymann
mesh_terms: D002648:Child; D003550:Cystic Fibrosis / Q000150:complications / Q000601:surgery*; D006801:Humans; D016031:Liver Transplantation / Q000009:adverse effects / Q000379:methods*; D016040:Lung Transplantation / Q000009:adverse effects / Q000379:methods*; D011183:Postoperative Complications
keywords: Allograft; Cystic fibrosis; Liver transplantation; Lung transplantation; Rejection