title: Highly sensitive detection of dipicolinic acid with a water-dispersible terbium-metal organic framework.
abstract: The sensitive detection of dipicolinic acid (DPA) is strongly associated with the sensing of bacterial organisms in food and many types of environmental samples. To date, the demand for a sensitive detection method for bacterial toxicity has increased remarkably. Herein, we investigated the DPA detection potential of a water-dispersible terbium-metal organic framework (Tb-MOF) based on the fluorescence quenching mechanism. The Tb-MOF showed a highly sensitive ability to detect DPA at a limit of detection of 0.04nM (linear range of detection: 1nM to 5µM) and also offered enhanced selectivity from other commonly associated organic molecules. The present study provides a basis for the application of Tb-MOF for direct, convenient, highly sensitive, and specific detection of DPA in the actual samples.
authors.affiliation: Central Scientific Instruments Organisation (CSIR-CSIO), Sector 30C, Chandigarh, 160030 India; Academy of Scientific and Innovative Research, CSIR-CSIO, Sector 30C, Chandigarh, 160030 India.
authors.forename: Neha
authors.initials: N
authors.lastname: Bhardwaj
authors.affiliation: Central Scientific Instruments Organisation (CSIR-CSIO), Sector 30C, Chandigarh, 160030 India; Academy of Scientific and Innovative Research, CSIR-CSIO, Sector 30C, Chandigarh, 160030 India.
authors.forename: Sanjeev
authors.initials: S
authors.lastname: Bhardwaj
authors.affiliation: Central Scientific Instruments Organisation (CSIR-CSIO), Sector 30C, Chandigarh, 160030 India; Academy of Scientific and Innovative Research, CSIR-CSIO, Sector 30C, Chandigarh, 160030 India.
authors.forename: Jyotsana
authors.initials: J
authors.lastname: Mehta
authors.affiliation: Department of Civil and Environmental Engineering, Hanyang University, 222 Wangsimni-Ro, Seoul, 04763 Korea. Electronic address: kkim61@hanyang.ac.kr.
authors.forename: Ki-Hyun
authors.initials: KH
authors.lastname: Kim
authors.affiliation: Central Scientific Instruments Organisation (CSIR-CSIO), Sector 30C, Chandigarh, 160030 India; Academy of Scientific and Innovative Research, CSIR-CSIO, Sector 30C, Chandigarh, 160030 India. Electronic address: dr.akashdeep@csio.res.in.
authors.forename: Akash
authors.initials: A
authors.lastname: Deep
mesh_terms: D015415:Biomarkers / Q000032:analysis; D008163:Luminescent Measurements / Q000379:methods*; D053768:Metal Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D053761:Nanocomposites / Q000737:chemistry* / Q000648:ultrastructure; D010848:Picolinic Acids / Q000032:analysis*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013171:Spores, Bacterial / Q000302:isolation & purification* / Q000378:metabolism; D013725:Terbium / Q000737:chemistry*; D014867:Water / Q000737:chemistry
chemical_list: D015415:Biomarkers; D010848:Picolinic Acids; D014867:Water; D013725:Terbium; C004860:dipicolinic acid
keywords: Dipicolinic acid; Fluorescence; Metal organic framework; Sensor; Terbium