title: Adding corticosteroids to the pudendal nerve block for pudendal neuralgia: a randomised, double-blind, controlled trial.
abstract: To compare the effect of corticosteroids combined with local anaesthetic versus local anaesthetic alone during infiltrations of the pudendal nerve for pudendal nerve entrapment.
  
  
  
  Randomised, double-blind, controlled trial.
  
  
  
  Multicentre study.
  
  
  
  201 patients were included in the study, with a subgroup of 122 women.
  
  
  
  CT-guided pudendal nerve infiltrations were performed in the sacrospinous ligament and Alcock's canal. There were three study arms: patients in Arm A (n = 68) had local anaesthetic alone, those in Arm B (n = 66) had local anaesthetic plus corticosteroid and those in Arm C (n = 67) local anaesthetic plus corticosteroid with a large volume of normal saline.
  
  
  
  The primary end-point was the pain intensity score at 3 months. Patients were regarded as responders (at least a 30-point improvement on a 100-point visual analogue scale of mean maximum pain over a 2-week period) or nonresponders.
  
  
  
  Three months' postinfiltration, 11.8% of patients in the local anaesthetic only arm (Arm A) were responders versus 14.3% in the local anaesthetic plus corticosteroid arms (Arms B and C). This difference was not statistically significant (P = 0.62). No statistically significant difference was observed in the female subgroup between Arm A and Arms B and C (P = 0.09). No significant difference was detected for the various pain assessment procedures, functional criteria or quality-of-life criteria.
  
  
  
  Corticosteroids provide no additional therapeutic benefits compared with local anaesthetic and should therefore no longer be used.
  
  
  
  Steroid infiltrations do not improve the results of local anaesthetic infiltrations in pudendal neuralgia.
authors.affiliation: Federative Centre of Pelvi-Perineology, CHU Nantes, Nantes, France.
authors.forename: J J
authors.initials: JJ
authors.lastname: Labat
authors.affiliation: Federative Centre of Pelvi-Perineology, CHU Nantes, Nantes, France.|Pain Unit, Centre Catherine de Sienne, Nantes, France.
authors.forename: T
authors.initials: T
authors.lastname: Riant
authors.affiliation: Pain Clinic, Hôpital Rothschild, Paris, France.
authors.forename: A
authors.initials: A
authors.lastname: Lassaux
authors.affiliation: Pain Unit, Centre Catherine de Sienne, Nantes, France.
authors.forename: B
authors.initials: B
authors.lastname: Rioult
authors.affiliation: Gynaecology Department, Polyclinique Hôtel-Dieu, Clermont-Ferrand, France.
authors.forename: B
authors.initials: B
authors.lastname: Rabischong
authors.affiliation: Centre Hospitalier de la Cote Basque, Bayonne, France.
authors.forename: M
authors.initials: M
authors.lastname: Khalfallah
authors.affiliation: DRCI, Hôtel Dieu, Nantes, France.
authors.forename: C
authors.initials: C
authors.lastname: Volteau
authors.affiliation: Digestive Physiology Department, Hôpital Charles Nicolle, Rouen, France.
authors.forename: A-M
authors.initials: AM
authors.lastname: Leroi
authors.affiliation: Federative Centre of Pelvi-Perineology, CHU Nantes, Nantes, France.|Gynaecology Department, Hôtel-Dieu, Nantes, France.
authors.forename: S
authors.initials: S
authors.lastname: Ploteau
mesh_terms: D000305:Adrenal Cortex Hormones / Q000008:administration & dosage*; D000779:Anesthetics, Local / Q000008:administration & dosage*; D004311:Double-Blind Method; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D008012:Lidocaine / Q000008:administration & dosage*; D008875:Middle Aged; D009407:Nerve Block / Q000379:methods*; D010147:Pain Measurement; D011446:Prospective Studies; D060525:Pudendal Nerve; D060545:Pudendal Neuralgia / Q000628:therapy*; D015641:Radiography, Interventional / Q000379:methods; D016896:Treatment Outcome
chemical_list: D000305:Adrenal Cortex Hormones; D000779:Anesthetics, Local; D008012:Lidocaine
keywords: Chronic pain; corticosteroid infiltrations; nerve block; pelvic pain; perineal pain; pudendal neuralgia