title: Antitumor and immunomodulatory activities of thiosemicarbazones and 1,3-Thiazoles in Jurkat and HT-29 cells.
abstract: Cancer remains a high incidence and mortality disease, causing around 8.2 million of deaths in the last year. Current chemotherapy needs to be expanded, making research for new drugs a necessary task. Immune system modulation is an emerging concept in cancer cell proliferation control. In fact, there are a number of mechanisms underlying the role immune system plays in tumor cells. In this work, we describe the structural design, synthesis, antitumor and immunomodulatory potential of 31 new 1,3-thiazole and thiosemicarbazone compounds. Cisplatin was used as anticancer drug control. Cytotoxicity against J774A.1 macrophages and antitumor activity against HT-29 and Jurkat cells was determined. These 1,3-thiazole and thiosemicarbazone compounds not only exhibited cytotoxicity in cancer cells, but were able to cause irreversible cancer cell damage by inducing necrosis and apoptosis. In addition, these compounds, especially pyridyl-thiazoles compounds, regulated immune factors such as interleukin 10 and tumor necrosis factor, possible by directing immune system in favor of modulating cancer cell proliferation. By examining their pharmacological activity, we were able to identify new potent and selective anticancer compounds.
authors.affiliation: Fundação Oswaldo Cruz, Centro de Pesquisa Aggeu Magalhães, Laboratório de Imunogenética, CEP 50670-420, Recife, PE, Brazil. Electronic address: thiago.andre.ufpe@gmail.com.
authors.forename: Thiago André R
authors.initials: TA
authors.lastname: Dos Santos
authors.affiliation: Fundação Oswaldo Cruz, Centro de Pesquisa Aggeu Magalhães, Laboratório de Imunogenética, CEP 50670-420, Recife, PE, Brazil. Electronic address: acllb2003@yahoo.com.br.
authors.forename: Aline Caroline
authors.initials: AC
authors.lastname: da Silva
authors.affiliation: Universidade Federal de Pernambuco, Departamento de Ciências Farmacêuticas, CEP 50740-520, Recife, PE, Brazil.
authors.forename: Elany Barbosa
authors.initials: EB
authors.lastname: Silva
authors.affiliation: Universidade Federal de Pernambuco, Departamento de Ciências Farmacêuticas, CEP 50740-520, Recife, PE, Brazil.
authors.forename: Paulo André Teixeira de Moraes
authors.initials: PA
authors.lastname: Gomes
authors.affiliation: Universidade Federal de Pernambuco, Departamento de Ciências Farmacêuticas, CEP 50740-520, Recife, PE, Brazil.
authors.forename: José Wanderlan Pontes
authors.initials: JW
authors.lastname: Espíndola
authors.affiliation: Universidade Federal de Pernambuco, Departamento de Ciências Farmacêuticas, CEP 50740-520, Recife, PE, Brazil.
authors.forename: Marcos Veríssimo de Oliveira
authors.initials: MV
authors.lastname: Cardoso
authors.affiliation: Fundação Oswaldo Cruz, Centro de Pesquisas Gonçalo Moniz, CEP 40296-710, Salvador, BA, Brazil.
authors.forename: Diogo Rodrigo Magalhaes
authors.initials: DR
authors.lastname: Moreira
authors.affiliation: Universidade Federal de Pernambuco, Departamento de Ciências Farmacêuticas, CEP 50740-520, Recife, PE, Brazil.
authors.forename: Ana Cristina Lima
authors.initials: AC
authors.lastname: Leite
authors.affiliation: Fundação Oswaldo Cruz, Centro de Pesquisa Aggeu Magalhães, Laboratório de Imunogenética, CEP 50670-420, Recife, PE, Brazil. Electronic address: valeria@cpqam.fiocruz.br.
authors.forename: Valéria R A
authors.initials: VR
authors.lastname: Pereira
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects; D019073:HT29 Cells; D006801:Humans; D007155:Immunologic Factors / Q000494:pharmacology*; D016753:Interleukin-10 / Q000096:biosynthesis; D019169:Jurkat Cells; D008264:Macrophages / Q000187:drug effects / Q000378:metabolism; D051379:Mice; D013844:Thiazoles / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D013882:Thiosemicarbazones / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D014409:Tumor Necrosis Factor-alpha / Q000096:biosynthesis
chemical_list: D000970:Antineoplastic Agents; D007155:Immunologic Factors; D013844:Thiazoles; D013882:Thiosemicarbazones; D014409:Tumor Necrosis Factor-alpha; D016753:Interleukin-10
keywords: 1,3-thiazoles; Cancer; Cell death; Drug development; Immune system; Thiosemicarbazones