title: Risk factor indicators in offspring of patients with premature coronary heart disease in Banja Luka region/Republic of Srpska/Bosnia and Herzegovina.
abstract: BACKGROUND
  Risk factor differences among offspring of patients with premature coronary heart disease (CHD) have not been widely studiem.
  
  
  METHODS
  We examined 161 persons from the region of Banja Luka, including 81 children (mean age: 25.9 years, 45.7% female) with a history of CHD and a control group of 80 persons (mean age: 24.1, 50% female). Medical history interviews and risk factor measurements were performed.
  
  
  RESULTS
  There were differences in mean body amss index (BMI) (26.1 kg/m(2) vs. 23.1 kg/m(2), p < 0.0001), waist circumference (87.7 cm vs. 83.9 cm, p = 0.002), hip circumference (99.3 cm vs. 95.84 cm, p < 0.002), systolic blood pressure (BP) (128.09 mm Hg vs. 122.7 mm Hg, p = 0.007), and diastolic BP (99.3 mm Hg vs. 95.8 mm Hg, p = 0.07). Moreover, HDL-cholesterol was significantly lower (1.1 mmol/l vs. 1.4 mmol/l, p = 0.0001), triglycerides significantly higher (2.2 mmol/l vs. 1.6 mmol/l, p = 0.001), and TC/HDL-ratio was significantly higher (5.1 vs. 4.0, p < 0.001) comparing cases and controls, respectively, adjusted for age, gender, and standard CHD risk factors total cholesterol, LDL and HDL cholesterol, smoking, systolic and diastolic BP, and BMI, those with HDL-C > 1.0 mmol/l in men and 1.2 mmol/l in women had a reduced odds (OR = 0.08, 95% CI: 0.02-0.34 of CHD as well as those with change of fat type (OR = 0.26, 95% CI: 0.11-0.60).
  
  
  CONCLUSIONS
  Children of parents with premature CHD have a significantly greater burden of CHD risk factors, with low HDL-C, in particular, being associated with an increased likelihood of being a child of a parent with premature CHD.
authors.affiliation: Department of Internal Medicine, School of Medicine, University of Banja Luka, Republic of Srpska, Bosnia and Herzegovina.
authors.forename: Dusko
authors.initials: D
authors.lastname: Vulic
authors.affiliation: Department of Cardiology, Clinical Center Banja Luka, Republic of Srpska, Bosnia and Herzegovina.
authors.forename: Sasa
authors.initials: S
authors.lastname: Loncar
authors.affiliation: Department of Cardiology, Clinical Center Banja Luka, Republic of Srpska, Bosnia and Herzegovina.
authors.forename: Miodrag
authors.initials: M
authors.lastname: Ostojic
authors.affiliation: Department of Statistics, Institute for Statitistics, Schol of Medicine, Belgrade, Serbia.
authors.forename: Jelena
authors.initials: J
authors.lastname: Marinkovic
authors.affiliation: Department of Internal Medicine, School of Medicine, University of Banja Luka, Republic of Srpska, Bosnia and Herzegovina.
authors.forename: Branka
authors.initials: B
authors.lastname: Vulic
authors.affiliation: Heart Disease Prevention Program, Division of Cardiology, Department of Medicine, University of California, Irvine, USA.
authors.forename: Nathan D
authors.initials: ND
authors.lastname: Wong
keywords: children; coronary heart disease; family history; lipids