title: Clinical impact of term-equivalent magnetic resonance imaging in extremely low-birth-weight infants at a regional NICU.
abstract: To evaluate the clinical impact of routine term-equivalent magnetic resonance imaging (TE-MRI) for extremely low-birth-weight infants at a regional neonatal intensive care unit.
  
  
  
  This is a single-center retrospective study evaluating preterm survivors who underwent TE-MRI. MRI abnormalities were compared between infants with and without cranial ultrasonography (CUS) abnormalities. Cost analysis comparing imaging modalities was also performed.
  
  
  
  TE-MRI use increased from 17% in 2006 to 76% in 2010. MRI detected new findings in nearly half of infants, whether or not they had known ultrasound abnormalities. MRI detected more cerebellar (18% vs 6%, P=0.04) and moderate white matter injury (12% vs 7%, P<0.001), and altered simulated neurological prognosis across developmental domains. The cost of TE-MRI was $1600, which was comparable to serial CUSs.
  
  
  
  TE-MRI detects new abnormalities and impacts developmental prognosis in the extremely low birth weight, which supports its use despite the added financial cost.
authors.affiliation: Division of Neonatology, Children's National Health System, Washington, DC, USA.|Department of Pediatrics, George Washington University School of Medicine and Health Sciences, Washington, DC, USA.
authors.forename: L
authors.initials: L
authors.lastname: Melbourne
authors.affiliation: Department of Pediatrics, George Washington University School of Medicine and Health Sciences, Washington, DC, USA.|Department of Neurology, Children's National Health System, Washington, DC, USA.
authors.forename: T
authors.initials: T
authors.lastname: Chang
authors.affiliation: Department of Pediatrics, George Washington University School of Medicine and Health Sciences, Washington, DC, USA.|Division of Diagnostic Imaging and Radiology, Children's National Health System, Washington, DC, USA.
authors.forename: J
authors.initials: J
authors.lastname: Murnick
authors.affiliation: Children's Hospitals Association, Overland Park, Kansas, USA.
authors.forename: I
authors.initials: I
authors.lastname: Zaniletti
authors.affiliation: Department of Pediatrics, George Washington University School of Medicine and Health Sciences, Washington, DC, USA.|Division of Psychology and Behavioral Health, Children's National Health System, Washington, DC, USA.
authors.forename: P
authors.initials: P
authors.lastname: Glass
authors.affiliation: Division of Neonatology, Children's National Health System, Washington, DC, USA.|Department of Pediatrics, George Washington University School of Medicine and Health Sciences, Washington, DC, USA.
authors.forename: A N
authors.initials: AN
authors.lastname: Massaro
mesh_terms: D001921:Brain / Q000002:abnormalities / Q000000981:diagnostic imaging*; D016022:Case-Control Studies; D004453:Echoencephalography; D005260:Female; D006801:Humans; D052577:Infant, Extremely Low Birth Weight; D062071:Infant, Extremely Premature; D007231:Infant, Newborn; D007235:Infant, Premature, Diseases / Q000000981:diagnostic imaging; D007363:Intensive Care Units, Neonatal / Q000706:statistics & numerical data; D008279:Magnetic Resonance Imaging / Q000191:economics / Q000379:methods*; D008297:Male; D012189:Retrospective Studies; D018709:Statistics, Nonparametric; D014463:Ultrasonography / Q000191:economics / Q000379:methods*