title: Enhancement of arterial pulsation during flow-mediated dilation is impaired in the presence of ischemic heart disease.
abstract: OBJECTIVE
  The aim of this study is to investigate the relationship between arterial pulse amplitude change under increased shear stress and the presence of ischemic heart disease (IHD).
  
  
  METHODS
  This study comprised 31 subjects, including 14 subjects with IHD. We investigated the change in brachial artery pulse amplitude during flow-mediated dilation (FMD) using ultrasonography.
  
  
  RESULTS
  The arterial pulse amplitude increased during FMD in 19 subjects, whereas it decreased in 12 subjects. There was a marked difference in the change in arterial pulse amplitude (the maximum amplitude of the arterial pulse amplitude during FMD/the arterial pulse amplitude at baseline) between subjects with and without IHD (0.98 ± 0.53 and 1.37 ± 0.53, p = 0.028). Furthermore, decreased arterial pulse amplitude during FMD was a significant predictor of IHD after adjustment of age, blood pressure, the presence of each type of coronary risks, the value of FMD and sex (p = 0.0001).
  
  
  CONCLUSIONS
  The decrease of arterial pulsation amplitude during FMD was a useful predictive parameter for IHD.
authors.affiliation: Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655 Japan.
authors.forename: Eisuke
authors.initials: E
authors.lastname: Amiya
authors.affiliation: Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655 Japan.
authors.forename: Masafumi
authors.initials: M
authors.lastname: Watanabe
authors.affiliation: Department of Pathophysiological Laboratory Sciences, Nagoya University Graduate School of Medicine, Nagoya, Aichi Japan.
authors.forename: Shogo
authors.initials: S
authors.lastname: Watanabe
authors.affiliation: Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655 Japan ; Department of Clinical Research Support Center, The University of Tokyo Hospital, Tokyo, Japan.
authors.forename: Munenori
authors.initials: M
authors.lastname: Takata
authors.affiliation: Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655 Japan.
authors.forename: Issei
authors.initials: I
authors.lastname: Komuro
keywords: Arterial pulsation; Flow-mediated dilation; Ischemic heart disease; Vascular ultrasound