title: 14-3-3zeta Positive Cells Show More Tumorigenic Characters in Human Glioblastoma.
abstract: OBJECTIVE
  Expression of 14-3-3zeta is upregulated in many cancer types and plays an important role in tumorigenesis. Our previous studies have shown that 14-3-3zeta has a positive expression and is associated with a poor prognosis in patients with glioblastoma. In this study, we investigated whether 14-3-3zeta positive cells show more tumorigenic character and stronger chemotherapy resistance.
  
  
  METHODS
  Six human glioblastoma cells lines were derived from the 6 patients with tumor, and the cells were sorted by 14-3-3zeta expression. The cell viability, invasion, tumorigenic ability and chemotherapy resistance were compared between the 14-3-3 positive and negative expression groups.
  
  
  RESULTS
  14-3-3zeta positive cells displayed oncogenic properties, more tumorigenic character, high invasiveness, tumorsphere formation ability and resistance to temozolomide chemotherapy treatment.
  
  
  CONCLUSIONS
  Cells with 14-3-3zeta positive expression show more tumorigenic character and should be administered other treatments in the future.
authors.affiliation: Wuhan General Hospital of Guangzhou Military Command, Department of Neurosurgery, Wuhan, China.
authors.forename: Zhonghua
authors.initials: Z
authors.lastname: Luo
authors.forename: Xiaoliang
authors.initials: X
authors.lastname: Yang
authors.forename: Lian-Ting
authors.initials: LT
authors.lastname: Ma
authors.forename: Zhiqun
authors.initials: Z
authors.lastname: Wu
authors.forename: Guozheng
authors.initials: G
authors.lastname: Xu
authors.forename: Xiaofeng
authors.initials: X
authors.lastname: Wang
authors.forename: Weidong
authors.initials: W
authors.lastname: Cao
mesh_terms: D048948:14-3-3 Proteins / Q000378:metabolism*; D045744:Cell Line, Tumor / Q000378:metabolism*; D002468:Cell Physiological Phenomena; D005909:Glioblastoma / Q000378:metabolism*; D006801:Humans
chemical_list: D048948:14-3-3 Proteins