title: Prognostic Superiority of Log Odds of Positive Lymph Nodes in Stage 3 Colorectal Cancer.
abstract: Objective To evaluate the prognostic value of the log odds of positive lymph nodes (LODDS) in stage 3 colorectal cancer (CRC) patients who have undergone curative resection. Methods We performed a retrospective review of 175 stage 3 CRC patients who underwent curative resection in Peking Union Medical College Hospital from 2005 to 2012. Patients were categorized respectively according to the AJCC/UICC N grade,the metastatic lymph node ratio (LNR),and the ratio of their LODDS. The relationship between the N grade,LNR,LODDS,and overall survival (OS) rates were assessed.Results The five-year disease-free survival (DFS) was significantly different among stage 3 CRC patients in different N grade (Χ(2)=33.1,P=0.000),LNR (Χ(2)=14.3,P=0.001),and LODDS (Χ(2)=14.9,P=0.001). Univariate analysis showed that TNM stage (Χ(2)=27.0,P=0.000),cancerous node(Χ(2)=3.6,P=0.040),N grade (Χ(2)=33.1,P=0.000),LNR (Χ(2)=14.3,P=0.001),and LODDS (Χ(2)=30.4,P=0.000) were related to OS. Multivariate analysis indicated that TNM stage (HR:1.84,95%CI:1.59～6.29,P=0.001) and LODDS classification (HR:1.34,95%CI:1.01～1.80,P=0.047) were independent prognostic factors for OS in stage 3 CRC patients. Conclusion LODDS is a good prognostic indicator in stage 3 CRC patients who have undergone curative resection.
authors.affiliation: 1Department of General Surgery,PUMC Hospital,CAMS and PUMC,Beijing 100730,China;
authors.forename: Min-er
authors.lastname: Zhong
authors.affiliation: 1Department of General Surgery,PUMC Hospital,CAMS and PUMC,Beijing 100730,China;
authors.forename: Lai
authors.lastname: Xu
authors.affiliation: 2Department of Laboratory,Yunyang Traditional Chinese Medical Hospital,Chongqing 404500,China
authors.forename: Qiong
authors.initials: Q
authors.lastname: Xu
authors.affiliation: 1Department of General Surgery,PUMC Hospital,CAMS and PUMC,Beijing 100730,China;
authors.forename: Wu-yang
authors.initials: WY
authors.lastname: Ji
authors.affiliation: 1Department of General Surgery,PUMC Hospital,CAMS and PUMC,Beijing 100730,China;
authors.forename: Bei-zhan
authors.lastname: Niu
authors.affiliation: 1Department of General Surgery,PUMC Hospital,CAMS and PUMC,Beijing 100730,China;
authors.forename: Hui-zhong
authors.lastname: Qiu
authors.affiliation: 1Department of General Surgery,PUMC Hospital,CAMS and PUMC,Beijing 100730,China;
authors.forename: Bin
authors.lastname: Wu
mesh_terms: D015179:Colorectal Neoplasms / Q000175:diagnosis* / Q000473:pathology; D018572:Disease-Free Survival; D006801:Humans; D008198:Lymph Nodes / Q000473:pathology*; D008207:Lymphatic Metastasis / Q000175:diagnosis; D015999:Multivariate Analysis; D009367:Neoplasm Staging; D011379:Prognosis; D012189:Retrospective Studies; D015996:Survival Rate