title: Chitosan/lecithin liposomal nanovesicles as an oral insulin delivery system.
abstract: In the present work, insulin-chitosan polyelectrolyte complexes associated to lecithin liposomes were investigated as a new carrier for oral delivery of insulin. The preparation was characterized in terms of particle size, zeta potential and encapsulation efficiency. Surface tension measurements revealed that insulin-chitosan polyelectrolyte complexes have some degree of hydrophobicity and should be added to lecithin liposomal dispersion and not the vice versa to prevent their adsorption on the surface. Stability of insulin was enhanced when it was associated to liposomes. Significant reduction of blood glucose levels was noticed after oral administration of liposomal preparation to streptozotocin diabetic rats compared to control. The hypoglycemic activity was more prolonged compared to subcutaneously administered insulin.
authors.affiliation: a Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy and Medical Sciences , Petra University , Amman , Jordan.
authors.forename: Mayyas
authors.initials: M
authors.lastname: Al-Remawi
authors.affiliation: b Department of Pharmaceutics and Pharmaceutical Technology, College of Pharmacy , Taif University , Taif , Saudi Arabia.
authors.forename: Amani
authors.initials: A
authors.lastname: Elsayed
authors.affiliation: c Department of Clinical Pharmacy, College of Pharmacy , Taif University , Taif , Saudi Arabia.
authors.forename: Ibrahim
authors.initials: I
authors.lastname: Maghrabi
authors.affiliation: b Department of Pharmaceutics and Pharmaceutical Technology, College of Pharmacy , Taif University , Taif , Saudi Arabia.
authors.forename: Mohammad
authors.initials: M
authors.lastname: Hamaidi
authors.affiliation: d Department of Drug Registration, Jordan Food and Drug Administration , Amman , Jordan.
authors.forename: Nisrein
authors.initials: N
authors.lastname: Jaber
mesh_terms: D000284:Administration, Oral; D000818:Animals; D048271:Chitosan / Q000737:chemistry*; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy; D004337:Drug Carriers / Q000737:chemistry*; D004355:Drug Stability; D007004:Hypoglycemic Agents / Q000008:administration & dosage* / Q000627:therapeutic use; D007328:Insulin / Q000008:administration & dosage* / Q000627:therapeutic use; D054709:Lecithins / Q000737:chemistry*; D008081:Liposomes; D008297:Male; D053758:Nanoparticles / Q000737:chemistry*; D017208:Rats, Wistar; D013499:Surface Properties
chemical_list: D004337:Drug Carriers; D007004:Hypoglycemic Agents; D007328:Insulin; D054709:Lecithins; D008081:Liposomes; D048271:Chitosan
keywords: Chitosan; insulin; lecithin; liposomes; nanovesicles