title: A study on comparative efficacy and cost effectiveness of Pregabalin and Duloxetine used in diabetic neuropathic pain.
abstract: OBJECTIVE
  The study was designed for comparing the efficacy and cost effectiveness of Pregabalin and Duloxetine used in Diabetic Neuropathic Pain.
  
  
  METHODS
  The prospective interventional 6 month study was conducted in a diabetic clinic of a 500 bedded tertiary care hospital in South India. The subjects having diagnosed with diabetic neuropathy and not treated with Pregabalin and Duloxetine or any other drugs of its class were selected. The data were collected using NPS and Neuro QoL questionnaires. The cost of both drugs used in the study was calculated as the mean of the price of 3 leading common brands of those drugs. The comparative efficacy was calculated by comparing the mean difference produced by both drugs in NPS and QoL scores. The cost effectiveness were calculated by ICER ratio.
  
  
  RESULTS
  The results have shown a significant improvement in the mean difference of NPS and Neuro QoL scores of both Pregabalin (p=<0.001) and Duloxetine (p=<0.001) before and after the therapy, the Duloxetine dominates over Pregabalin in both. The mean cost of Pregabalin for 3 months therapy was found to be INR 668.7 and that for Duloxetine was INR 756. Duloxetine showed a better effect but more expensive. ICER ratio was calculated and found that a cost of INR 61.47 per extra QoL gained by Duloxetine.
  
  
  CONCLUSIONS
  The study have revealed that, both drugs are found to be effective.On conducting cost effective analysis, a significant better improvement in QoL of patients was obtained by Duloxetine with comparatively mild increase in the price.
authors.affiliation: Department of Pharmacy Practice, National College of Pharmacy, Kozhikode, Kerala, India.
authors.forename: Midhun K
authors.initials: MK
authors.lastname: Roy
authors.affiliation: Department of Pharmacy Practice, National College of Pharmacy, Kozhikode, Kerala, India.
authors.forename: Abaedha Susan
authors.initials: AS
authors.lastname: Kuriakose
authors.affiliation: Department of Pharmaceutics, National College of Pharmacy, Manassery, Kozhikode, India. Electronic address: sujithvarma@yahoo.com.
authors.forename: Sujith K
authors.initials: SK
authors.lastname: Varma
authors.affiliation: Department of Pharmacy Practice, National College of Pharmacy, Kozhikode, Kerala, India.
authors.forename: Lejo A
authors.initials: LA
authors.lastname: Jacob
authors.affiliation: Department of Pharmacy Practice, National College of Pharmacy, Kozhikode, Kerala, India.
authors.forename: N Jeena
authors.initials: NJ
authors.lastname: Beegum
mesh_terms: D000328:Adult; D000927:Anticonvulsants / Q000191:economics* / Q000627:therapeutic use; D000928:Antidepressive Agents / Q000191:economics* / Q000627:therapeutic use; D003362:Cost-Benefit Analysis; D003929:Diabetic Neuropathies / Q000150:complications / Q000191:economics*; D000068736:Duloxetine Hydrochloride / Q000191:economics* / Q000627:therapeutic use; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007194:India; D008297:Male; D008875:Middle Aged; D009437:Neuralgia / Q000188:drug therapy / Q000191:economics* / Q000209:etiology; D059408:Pain Management; D000069583:Pregabalin / Q000191:economics* / Q000627:therapeutic use; D011379:Prognosis; D011446:Prospective Studies
chemical_list: D000927:Anticonvulsants; D000928:Antidepressive Agents; D000069583:Pregabalin; D000068736:Duloxetine Hydrochloride
keywords: Cost effectiveness; Diabetic neuropathic pain; Duloxetine; Pregabalin; Quality of life