title: Additive Biomanufacturing: An Advanced Approach for Periodontal Tissue Regeneration.
abstract: Periodontitis is defined as a chronic inflammatory condition, characterized by destruction of the periodontium, composed of hard (i.e. alveolar bone and cementum) and soft tissues (i.e. gingiva and periodontal ligament) surrounding and supporting the teeth. In severe cases, reduced periodontal support can lead to tooth loss, which requires tissue augmentation or procedures that initiate a repair, yet ideally a regenerative response. However, mimicking the three-dimensional complexity and functional integration of the different tissue components via scaffold- and/or matrix-based guided tissue engineering represents a great challenge. Additive biomanufacturing, a manufacturing method in which objects are designed and fabricated in a layer-by-layer manner, has allowed a paradigm shift in the current manufacturing of medical devices and implants. This shift from design-to-manufacture to manufacture-to-design, seen from a translational research point of view, provides the biomedical engineering and periodontology communities a technology with the potential to achieve tissue regeneration instead of repair. In this review, the focus is put on additively biomanufactured scaffolds for periodontal applications. Besides a general overview of the concept of additive biomanufacturing within this field, different developed scaffold designs are described. To conclude, future directions regarding advanced biomaterials and additive biomanufacturing technologies for applications in regenerative periodontology are highlighted.
authors.affiliation: Department of Orthopedics, University Medical Center Utrecht, Utrecht, The Netherlands.
authors.forename: Sarah-Sophia D
authors.initials: SD
authors.lastname: Carter
authors.affiliation: Department of Orthopedics, University Medical Center Utrecht, Utrecht, The Netherlands.|Biofabrication Facility, Regenerative Medicine Center Utrecht, University Medical Center Utrecht, Utrecht, The Netherlands.
authors.forename: Pedro F
authors.initials: PF
authors.lastname: Costa
authors.affiliation: Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Australia.
authors.forename: Cedryck
authors.initials: C
authors.lastname: Vaquette
authors.affiliation: School of Dentistry and Oral Health, Griffith University, Gold Coast, Australia.|Menzies Health Institute Queensland, Griffith University, Gold Coast, Australia.
authors.forename: Saso
authors.initials: S
authors.lastname: Ivanovski
authors.affiliation: Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Australia. dietmar.hutmacher@qut.edu.au.|Institute for Advanced Study, Technical University Munich, Munich, Germany. dietmar.hutmacher@qut.edu.au.
authors.forename: Dietmar W
authors.initials: DW
authors.lastname: Hutmacher
authors.affiliation: Department of Orthopedics, University Medical Center Utrecht, Utrecht, The Netherlands. j.malda@umcutrecht.nl.|Biofabrication Facility, Regenerative Medicine Center Utrecht, University Medical Center Utrecht, Utrecht, The Netherlands. j.malda@umcutrecht.nl.|Department of Equine Sciences, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands. j.malda@umcutrecht.nl.
authors.forename: Jos
authors.initials: J
authors.lastname: Malda
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000627:therapeutic use*; D005881:Gingiva / Q000502:physiology*; D006801:Humans; D020007:Implants, Experimental; D010513:Periodontal Ligament / Q000502:physiology*; D010518:Periodontitis / Q000378:metabolism / Q000628:therapy; D012038:Regeneration; D054457:Tissue Scaffolds
chemical_list: D001672:Biocompatible Materials
keywords: Bioprinting; Cell sheet engineering; Electrospinning; Guided tissue regeneration; Nanotechnology; Periodontology; Scaffolds; Tissue engineering & regenerative medicine (TE&RM)