title: Prostate tissue retrieval after holmium laser enucleation of the prostate; assessment of non-morcellation approaches.
abstract: OBJECTIVE
  To review non-morcellation approaches for tissue retrieval after holmium laser enucleation of the prostate (HoLEP) and whether these approaches demolish the advantages of the HoLEP procedure.
  
  
  METHODS
  We reviewed our prospectively maintained laser prostate database for HoLEP procedures where non-morcellation approaches were used for retrieval of the enucleated adenoma. Non-morcellation approaches were adopted in cases of morcellator malfunction or whenever concomitant pathology indicated laparotomy. Patients were stratified into the laparotomy group (Group I) or the transurethral resection (TUR) group (Group II). Safety and efficacy of each approach were assessed and compared.
  
  
  RESULTS
  Between August 2012 and July 2015, of 392 HoLEP procedures non-morcellation approaches were used for tissue retrieval in 37 (9.4%). In 19 procedures a laparotomy approach was adopted (17 mini-laparotomies and two conventional laparotomies for concomitant diverticulectomy). TUR of the enucleated adenoma was adopted in 18 patients. Baseline demographic data and indications for surgery were comparable between the groups. However, significantly larger prostates were treated in Group I. There were no significant differences between the groups for tissue retrieval time, histopathological findings of retrieved tissue, and peri-procedure biochemical changes. However, significantly more tissue was retrieved (median tissue weight 115 vs 38 g) and at a faster rate (4.6 vs 1.09 g/min) in Group I. The median hospital stay was similar in both groups, but the median time to catheter removal was longer in Group I (5 vs 2 days). Minimal and similar peri-procedure complications were reported in both groups and in both groups there was a significant and comparable improvement in all urinary outcome measures.
  
  
  CONCLUSIONS
  In the absence or malfunction of a tissue morcellator, or whenever concomitant pathology indicates laparotomy, non-morcellation tissue retrieval approaches are feasible options for endourologists practicing transurethral enucleation of prostate adenoma. These approaches are valid alternatives retaining most of the advantages of the transurethral prostate enucleation procedure.
authors.affiliation: Prostate Unit, Urology and Nephrology Center, Mansoura University, Mansoura, Egypt.
authors.forename: Ahmed M
authors.initials: AM
authors.lastname: Elshal
authors.affiliation: Prostate Unit, Urology and Nephrology Center, Mansoura University, Mansoura, Egypt.
authors.forename: Yasser
authors.initials: Y
authors.lastname: Eldemerdash
authors.affiliation: Prostate Unit, Urology and Nephrology Center, Mansoura University, Mansoura, Egypt.
authors.forename: Ramy
authors.initials: R
authors.lastname: Mekkawy
authors.affiliation: Prostate Unit, Urology and Nephrology Center, Mansoura University, Mansoura, Egypt.
authors.forename: Diaa-Eldin
authors.initials: DE
authors.lastname: Taha
authors.affiliation: Prostate Unit, Urology and Nephrology Center, Mansoura University, Mansoura, Egypt.
authors.forename: Mahmoud
authors.initials: M
authors.lastname: Laymon
authors.affiliation: Prostate Unit, Urology and Nephrology Center, Mansoura University, Mansoura, Egypt.
authors.forename: Ahmed R
authors.initials: AR
authors.lastname: El-Nahas
authors.affiliation: Prostate Unit, Urology and Nephrology Center, Mansoura University, Mansoura, Egypt.
authors.forename: Ahmed
authors.initials: A
authors.lastname: El-Assmy
keywords: Enucleation; HoLEP, holmium laser enucleation of the prostate; Laser; Morcellation; PVR, post-void residual urine volume; Prostate; Qmax, maximum urinary flow rate; TUR, transurethral resection; TURP