title: The Role of Aqueous Aerosols in the "Glyoxylate Scenario": An Experimental Approach.
abstract: The origin of life is one of the fundamental questions in science. Eschenmoser proposed the "glyoxylate scenario", in which plausible abiotic synthesis pathways were suggested to be compatible with the constraints of prebiotic chemistry. In this proposal, the stem compound is HCN. In this work, we explore the "glyoxylate scenario" through several syntheses of HCN polymers, paying particular attention to the role of the aqueous aerosols, together with statistical methods, as a step to elucidate the synthetic problem of the origin of life. The soluble and insoluble HCN polymers synthetized were analyzed by GC-MS. We identified, for the first time, glyoxylic acid in these polymers, together with some constituents of the reductive tricarboxylic acid cycle, amino acids and several N-heterocycles. The findings presented herein, as the first global approach to the "glyoxylate scenario", give full effect to this hypothesis and prove that aqueous aerosols could play an important role in this plausible scene of the origin of life.
authors.affiliation: Departamento de Evolución Molecular, Centro de Astrobiología (INTA-CSIC), Ctra. Torrejón-Ajlavir, km 4,8, 28850, Torrejón de Ardoz, Madrid, Spain.
authors.forename: Margarita R
authors.initials: MR
authors.lastname: Marín-Yaseli
authors.affiliation: Departamento de Evolución Molecular, Centro de Astrobiología (INTA-CSIC), Ctra. Torrejón-Ajlavir, km 4,8, 28850, Torrejón de Ardoz, Madrid, Spain.
authors.forename: Elena
authors.initials: E
authors.lastname: González-Toril
authors.affiliation: Departamento de Evolución Molecular, Centro de Astrobiología (INTA-CSIC), Ctra. Torrejón-Ajlavir, km 4,8, 28850, Torrejón de Ardoz, Madrid, Spain.
authors.forename: Cristina
authors.initials: C
authors.lastname: Mompeán
authors.affiliation: Departamento de Evolución Molecular, Centro de Astrobiología (INTA-CSIC), Ctra. Torrejón-Ajlavir, km 4,8, 28850, Torrejón de Ardoz, Madrid, Spain. ruizbm@cab.inta-csic.es.
authors.forename: Marta
authors.initials: M
authors.lastname: Ruiz-Bermejo
keywords: HCN polymers; glyoxylate scenario; protometabolism; synthetic biology; synthetic methods