title: Association between fibroblast growth factor receptor-2 gene polymorphism and risk of breast cancer in Chinese populations: A HuGE review and meta-analysis.
abstract: OBJECTIVE
  To evaluate the effect of fibroblast growth factor receptor.2. (FGFR2) on genetic susceptibility for breast cancer. (BC) in Chinese populations.
  
  
  METHODS
  A computerized literature search was carried out in PubMed, Chinese Biomedical Database. (CBM), and Chinese National Knowledge Infrastructure. (CNKI) to collect relevant articles. Pooled odds ratio. (OR) and 95% confidence interval. (CI) were used to assess the strength of the associations.
  
  
  RESULTS
  A total of 21 articles involving a total of 15 polymorphisms of the FGFR2 gene were included in the meta-analysis. Due to the limited studies for rs17102287, rs2981578, rs3135718, rs3803662, rs3750817, rsl0510097, rsl7542768, rs13387042, and rs1982073; we only pooled the six polymorphisms. (rs11200014, rs1219648, rs2420946, rs2912778, rs2981579, and rs2981582) into this meta.
  
  
  METHODS
  Overall, significantly increased BC risk was associated with five polymorphisms. (rs2981579, rs2981582, rs1219648, rs2420946, and rs2912778) when all studies were pooled into the meta.
  
  
  METHODS
  When stratified by ethnicity and source of controls, similar results were also detected. However, for rs2981579 no significant association was found among Chinese Han in all genetic models.
  
  
  CONCLUSIONS
  Our meta-analysis suggests that FGFR2 is likely an important genetic marker contributing to susceptibility of BC. We recommend that these single nucleotide polymorphisms to be included in future association studies and functional assays.
authors.affiliation: Department of Pathology, Health Science Center, Hebei University, Baoding, People's Republic of China.
authors.forename: Yong-Bin
authors.initials: YB
authors.lastname: Yang
authors.affiliation: Library, Hebei University, Baoding, People's Republic of China.
authors.forename: Zhan-Xue
authors.initials: ZX
authors.lastname: Zhao
authors.affiliation: Library, Hebei University, Baoding, People's Republic of China.
authors.forename: Wei
authors.initials: W
authors.lastname: Huang
authors.affiliation: Department of Pathology, Health Science Center, Hebei University, Baoding, People's Republic of China.
authors.forename: Hui
authors.initials: H
authors.lastname: Liu
authors.affiliation: Department of Pathology, Health Science Center, Hebei University, Baoding, People's Republic of China.
authors.forename: Yan-Li
authors.initials: YL
authors.lastname: Tan
authors.affiliation: Department of Obstetrics and Gynecology, Affiliated Hospital of Hebei University, Baoding, People's Republic of China.
authors.forename: Wei-Ming
authors.initials: WM
authors.lastname: Wang
mesh_terms: D000483:Alleles; D044466:Asian People / Q000235:genetics; D001943:Breast Neoplasms / Q000235:genetics*; D002681:China; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D017594:Publication Bias; D051497:Receptor, Fibroblast Growth Factor, Type 2 / Q000235:genetics*; D012306:Risk
chemical_list: D051497:Receptor, Fibroblast Growth Factor, Type 2