title: Corpus callosum integrity is affected by mood disorders and also by the suicide attempt history: A diffusion tensor imaging study.
abstract: Some MRI studies have noted alterations in the corpus callosum (CC) white matter integrity of individuals with mood disorders and also in patients with suicidal behavior. We investigated the specific impact of suicidal behavior on CC integrity in mood disorders.
  
  
  
  CC structural changes were assessed by diffusion tensor imaging (DTI) in 121 women 18-50-year-old): 41 with bipolar disorder (BD), 50 with major depressive disorder (MDD) and 30 healthy controls (HC). Fractional anisotropy (FA) and DTI metrics were calculated for the genu, body and splenium of CC and compared in the three groups by MANCOVA. Then, they were re-analyzed relative to the suicide attempt history within the MDD and BD groups and to the suicide number/severity.
  
  
  
  FA values for the CC genu and body were lower in non-suicide attempters with BD than with MDD and in HC. Conversely, FA values for all CC regions were significantly lower in suicide attempters with BD than in HC. Finally, higher number of suicide attempts (>2) and elevated Suicidal Intent Scale score were associated with significant splenium alterations.
  
  
  
  Limitations include the cross-sectional design (non-causal study), the potential influence of medications and concerns about the generalizability to men.
  
  
  
  Genu and body are altered in non-suicide attempters with BD, while splenium is specifically altered in suicide attempters, independently from their psychiatric status. History of suicide attempts may be a source of heterogeneity in the association between CC alterations and BD and may partially explain the variable results of previous studies.
authors.affiliation: Inserm, U1061, La Colombière Hospital, Montpellier F-34093, France; University of Montpellier, Montpellier F-34000, France; CHRU Montpellier, Montpellier F-34093, France.
authors.forename: Fabienne
authors.initials: F
authors.lastname: Cyprien
authors.affiliation: University of Montpellier, Montpellier F-34000, France; CHRU Montpellier, Montpellier F-34093, France.
authors.forename: Nicolas Menjot
authors.initials: NM
authors.lastname: de Champfleur
authors.affiliation: University of Montpellier, Montpellier F-34000, France; CHRU Montpellier, Montpellier F-34093, France; CNRS, UMR 5221, Montpellier F-34093, France.
authors.forename: Jérémy
authors.initials: J
authors.lastname: Deverdun
authors.affiliation: Inserm, U1061, La Colombière Hospital, Montpellier F-34093, France; University of Montpellier, Montpellier F-34000, France; CHRU Montpellier, Montpellier F-34093, France.
authors.forename: Emilie
authors.initials: E
authors.lastname: Olié
authors.affiliation: CHRU Montpellier, Montpellier F-34093, France.
authors.forename: Emmanuelle
authors.initials: E
authors.lastname: Le Bars
authors.affiliation: University of Montpellier, Montpellier F-34000, France; CHRU Montpellier, Montpellier F-34093, France.
authors.forename: Alain
authors.initials: A
authors.lastname: Bonafé
authors.affiliation: Inserm, U1061, La Colombière Hospital, Montpellier F-34093, France; University of Montpellier, Montpellier F-34000, France; CHRU Montpellier, Montpellier F-34093, France; CIC 1001, Montpellier F-34000, France.
authors.forename: Thibault
authors.initials: T
authors.lastname: Mura
authors.affiliation: McGill University, Department of Psychiatry, Canada; Douglas Mental Health University Institute, McGill Group for Suicide Studies, Montréal, Québec, Canada.
authors.forename: Fabrice
authors.initials: F
authors.lastname: Jollant
authors.affiliation: Inserm, U1061, La Colombière Hospital, Montpellier F-34093, France; University of Montpellier, Montpellier F-34000, France; CHRU Montpellier, Montpellier F-34093, France; Fondamental Foundation, France. Electronic address: sylvaine.artero@inserm.fr.
authors.forename: Philippe
authors.initials: P
authors.lastname: Courtet
authors.affiliation: Inserm, U1061, La Colombière Hospital, Montpellier F-34093, France; University of Montpellier, Montpellier F-34000, France. Electronic address: sylvaine.artero@inserm.fr.
authors.forename: Sylvaine
authors.initials: S
authors.lastname: Artero
mesh_terms: D000328:Adult; D016880:Anisotropy; D001714:Bipolar Disorder / Q000000981:diagnostic imaging*; D016022:Case-Control Studies; D003337:Corpus Callosum / Q000000981:diagnostic imaging*; D003430:Cross-Sectional Studies; D003865:Major Depressive Disorder / Q000000981:diagnostic imaging*; D056324:Diffusion Tensor Imaging; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D019964:Mood Disorders / Q000000981:diagnostic imaging; D013406:Suicide, Attempted; D066127:White Matter / Q000000981:diagnostic imaging*; D055815:Young Adult
keywords: Bipolar disorder; Corpus callosum; Diffusion tensor imaging; Major depressive disorder; Mood disorders; Suicide