title: Synthesis and crystal structures of cobalt(II), cadmium(II), and zinc(II) complexes of 4-nitro phenylcyanamide: enhancing the biological properties through bound to human serum albumin.
abstract: Metal complexes of the type [Co(phen)2(4-NO2pcyd)2].CH3OH, 1, [Zn(phen)2(4-NO2pcyd)2].CH3OH, 2, [Cd(phen)2(4-NO2pcyd)2], and 3, (phen = 1,10-phenanthroline, 4-NO2pcyd = 4-nitro phenylcyanamide) have been studied. The synthesis, characterization, and the biological activities of complexes 1-3 have been investigated. The geometries of complexes 1-3 were confirmed by single-crystal X-ray crystallography. The interactions of complexes 1-3 with human serum albumin (HSA) were studied using fluorescence and circular dichroism spectroscopy. The thermodynamic studies have showed the reaction for the binding of complexes 1-3 with HSA is hydrophobic (ΔH0˂ 0 and ΔS0> 0). The in vitro cytotoxic potential of complexes 1-3 and their complexes with HSA were examined. The complexes 1-3 with HSA enhance about 3-fold cytotoxicity in cancer cells lines.
authors.affiliation: a Department of Chemistry , Isfahan University of Technology , Isfahan 84156-83111 , Iran.
authors.forename: Mehdi
authors.initials: M
authors.lastname: Jazestani
authors.affiliation: a Department of Chemistry , Isfahan University of Technology , Isfahan 84156-83111 , Iran.
authors.forename: Hossein
authors.initials: H
authors.lastname: Chiniforoshan
authors.affiliation: a Department of Chemistry , Isfahan University of Technology , Isfahan 84156-83111 , Iran.
authors.forename: Leila
authors.initials: L
authors.lastname: Tabrizi
authors.affiliation: b School of Chemistry , National University of Ireland Galway , University Road, Galway , Ireland.
authors.forename: Patrick
authors.initials: P
authors.lastname: McArdle
mesh_terms: D001665:Binding Sites; D002104:Cadmium / Q000737:chemistry; D002942:Circular Dichroism; D003035:Cobalt / Q000737:chemistry; D056831:Coordination Complexes / Q000138:chemical synthesis / Q000737:chemistry*; D003300:Copper / Q000737:chemistry; D018360:Crystallography, X-Ray; D003484:Cyanamide / Q000737:chemistry*; D006801:Humans; D011485:Protein Binding / Q000187:drug effects; D000075462:Serum Albumin, Human / Q000737:chemistry*; D015032:Zinc / Q000737:chemistry
chemical_list: D056831:Coordination Complexes; D002104:Cadmium; D003035:Cobalt; D003484:Cyanamide; D003300:Copper; D015032:Zinc; D000075462:Serum Albumin, Human
keywords: 4-nitro phenylcyanamide; DNA binding; DNA cleavage; cytotoxicity; metal complexes