title: Estimation of Tumor Interstitial Fluid Pressure (TIFP) Noninvasively.
abstract: Tumor interstitial fluid pressure (TIFP), is a physiological parameter with demonstrated predictive value for a tumor's aggressiveness, drug delivery, as well as response to treatments such as radiotherapy and chemotherapy. Despite its utility, measurement of TIFP has been limited by the need for invasive procedures. In this work, the theoretical basis for approaching the absolute value of TIFP and the experimental method for noninvasively measuring TIFP are presented. Given specific boundary and continuity conditions, we convert theoretical variables into measurable variables by applying MRI technology. The work shows that TIFP in the central region of the tumor can be estimated by an analysis of the variation of tissue fluid motion in the tumor rim and surrounding tissue. It is determined from three noninvasive measurable parameters: i) an estimate of the velocity of the tumor interstitial fluid at the tumor surface, which is maximal, ii) a measurement of the distance from the tumor surface to where the tumor exudates are absorbed (or normalized), and iii) an estimate of the hydraulic conductivity of the interstitium through which the tumor exudate travels. We experimentally show that the fluid flow within the tumor rim is not uniform, even for a round shaped tumor, and demonstrate the procedures for the noninvasive measurement of TIFP.
authors.affiliation: Department of Physics, University of Windsor, Windsor, Ontario, Canada.
authors.forename: Long Jian
authors.initials: LJ
authors.lastname: Liu
authors.affiliation: Department of Physics, University of Windsor, Windsor, Ontario, Canada.|Department of Radiation Oncology, Henry Ford Hospital, Detroit, Michigan, United States of America.
authors.forename: Stephen L
authors.initials: SL
authors.lastname: Brown
authors.affiliation: Department of Radiation Oncology, Henry Ford Hospital, Detroit, Michigan, United States of America.|Department of Neurology, Henry Ford Hospital, Detroit, Michigan, United States of America.
authors.forename: James R
authors.initials: JR
authors.lastname: Ewing
authors.affiliation: Department of Radiology, Windsor Regional Hospital, Windsor, Ontario, Canada.
authors.forename: Brigitte D
authors.initials: BD
authors.lastname: Ala
authors.affiliation: Department of Radiation Oncology, Windsor Regional Hospital, Windsor, Ontario, Canada.
authors.forename: Kenneth M
authors.initials: KM
authors.lastname: Schneider
authors.affiliation: Department of Physics, University of Windsor, Windsor, Ontario, Canada.
authors.forename: Mordechay
authors.initials: M
authors.lastname: Schlesinger
mesh_terms: D001826:Body Fluids; D001943:Breast Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology*; D005260:Female; D006801:Humans; D008113:Liver Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology*; D008279:Magnetic Resonance Imaging; D008962:Models, Theoretical; D011312:Pressure