title: The Rhesus Monkey Connectome Predicts Disrupted Functional Networks Resulting from Pharmacogenetic Inactivation of the Amygdala.
abstract: Contemporary research suggests that the mammalian brain is a complex system, implying that damage to even a single functional area could have widespread consequences across the system. To test this hypothesis, we pharmacogenetically inactivated the rhesus monkey amygdala, a subcortical region with distributed and well-defined cortical connectivity. We then examined the impact of that perturbation on global network organization using resting-state functional connectivity MRI. Amygdala inactivation disrupted amygdalocortical communication and distributed corticocortical coupling across multiple functional brain systems. Altered coupling was explained using a graph-based analysis of experimentally established structural connectivity to simulate disconnection of the amygdala. Communication capacity via monosynaptic and polysynaptic pathways, in aggregate, largely accounted for the correlational structure of endogenous brain activity and many of the non-local changes that resulted from amygdala inactivation. These results highlight the structural basis of distributed neural activity and suggest a strategy for linking focal neuropathology to remote neurophysiological changes.
authors.affiliation: Department of Psychiatry and Behavioral Sciences, University of California, Davis, Sacramento, CA 95817, USA; The MIND Institute, University of California, Davis, Sacramento, CA 95817, USA; Center for Neuroscience, University of California, Davis, Davis, CA 95616, USA.
authors.forename: David S
authors.initials: DS
authors.lastname: Grayson
authors.affiliation: Department of Psychiatry and Behavioral Sciences, University of California, Davis, Sacramento, CA 95817, USA; California National Primate Research Center, University of California, Davis, Davis, CA 95616, USA.
authors.forename: Eliza
authors.initials: E
authors.lastname: Bliss-Moreau
authors.affiliation: Department of Psychiatry and Behavioral Sciences, University of California, Davis, Sacramento, CA 95817, USA; California National Primate Research Center, University of California, Davis, Davis, CA 95616, USA.
authors.forename: Christopher J
authors.initials: CJ
authors.lastname: Machado
authors.affiliation: Department of Psychiatry and Behavioral Sciences, University of California, Davis, Sacramento, CA 95817, USA; The MIND Institute, University of California, Davis, Sacramento, CA 95817, USA; California National Primate Research Center, University of California, Davis, Davis, CA 95616, USA.
authors.forename: Jeffrey
authors.initials: J
authors.lastname: Bennett
authors.affiliation: Rotman Research Institute, Baycrest Centre, Toronto, ON M6A 2E1, Canada.
authors.forename: Kelly
authors.initials: K
authors.lastname: Shen
authors.affiliation: Oregon National Primate Research Center, Beaverton, OR 97006, USA.
authors.forename: Kathleen A
authors.initials: KA
authors.lastname: Grant
authors.affiliation: Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, OR 97239, USA; Department of Psychiatry, Oregon Health and Science University, Portland, OR 97239, USA; Advanced Imaging Research Center, Oregon Health and Science University, Portland, OR 97239, USA.
authors.forename: Damien A
authors.initials: DA
authors.lastname: Fair
authors.affiliation: Department of Psychiatry and Behavioral Sciences, University of California, Davis, Sacramento, CA 95817, USA; The MIND Institute, University of California, Davis, Sacramento, CA 95817, USA; Center for Neuroscience, University of California, Davis, Davis, CA 95616, USA; California National Primate Research Center, University of California, Davis, Davis, CA 95616, USA. Electronic address: dgamaral@ucdavis.edu.
authors.forename: David G
authors.initials: DG
authors.lastname: Amaral
mesh_terms: D000679:Amygdala / Q000503:physiopathology*; D000818:Animals; D063132:Connectome / Q000379:methods; D008253:Macaca mulatta; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008959:Models, Neurological; D009415:Nerve Net / Q000502:physiology / Q000503:physiopathology*; D009434:Neural Pathways / Q000503:physiopathology*; D010597:Pharmacogenetics / Q000379:methods