title: The Role of Transoral Robotic Surgery in the Management of HPV Negative Oropharyngeal Squamous Cell Carcinoma.
abstract: The incidence of oropharyngeal squamous cell carcinoma (OPSCC) is on the rise. This is largely due to the rapid increase in HPV positive OPSCC, which has been shown to confer a survival advantage. HPV negative OPSCC, however, has a more aggressive tumor biology and is a challenge to treat with standard current therapies. Chemoradiation has demonstrated poor locoregional control in HPV negative OPSCC, and open surgeries are associated with high morbidity. Transoral robotic surgery (TORS) has been proposed as an option to both intensify treatment and decrease surgical morbidity for patients with HPV negative OPSCC. TORS can be utilized as a primary treatment or in persistent, recurrent, or second primary OPSCC. There is emerging data showing improved functional outcomes with TORS versus open surgery or chemoradiation. Unfortunately, there have been no randomized trials comparing TORS to chemoradiation in HPV negative OPSCC. This article will review utility of TORS for HPV negative OPSCC.
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, National Naval Medical Center San Diego, 34800 Bob Wilson Dr, San Deigo, CA, 92134, USA.
authors.forename: Ryan
authors.initials: R
authors.lastname: Sload
authors.affiliation: Department Head and Neck Surgery, MD Anderson Cancer Center, 1400 Pressler Street, Unit 1445, Houston, TX, 77030, USA.
authors.forename: Natalie
authors.initials: N
authors.lastname: Silver
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Tulane University, 1430 Tulane Avenue, New Orleans, LA, 70112, USA.
authors.forename: Basit Abjul
authors.initials: BA
authors.lastname: Jawad
authors.affiliation: Department Head and Neck Surgery, MD Anderson Cancer Center, 1400 Pressler Street, Unit 1445, Houston, TX, 77030, USA. NGross@MDAnderson.org.
authors.forename: Neil D
authors.initials: ND
authors.lastname: Gross
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000473:pathology / Q000601:surgery* / Q000821:virology; D006801:Humans; D009959:Oropharyngeal Neoplasms / Q000473:pathology / Q000601:surgery* / Q000821:virology; D027383:Papillomaviridae / Q000472:pathogenicity; D065287:Robotic Surgical Procedures
keywords: HPV negative; Oropharynx; Squamous cell carcinoma of the oropharynx; TORS; Transoral robotic surgery