title: Pancreatic developmental defect evaluated by celiac artery angiography in a patient with MODY5.
abstract: The hepatocyte nuclear factor 1β gene (HNF1B) is responsible for maturity-onset diabetes of the young type 5 (MODY5), which is characterized by early-onset diabetes mellitus and urogenital malformations. HNF1B is expressed during visceral endoderm formation. We identified a disruption of the great pancreatic artery in a patient with MODY5 with no pancreatic body or tail. Our finding supports the significance of HNF1B in the development of the pancreas.
authors.affiliation: Diabetes Center, Tokyo Women's Medical University, Tokyo, Japan; Tokyo Women's Medical University Institute of Medical Genetics, Tokyo, Japan; Tokyo Women's Medical University Institute of Integrated Medical Science, Tokyo, Japan.
authors.forename: Naoko
authors.identifier: 0000-0002-1857-7890
authors.initials: N
authors.lastname: Iwasaki
authors.affiliation: Department of Cardiovascular Medicine, Nippon Medical School , Tokyo, Japan.
authors.forename: Masashi
authors.initials: M
authors.lastname: Tsurumi
authors.affiliation: Department of Cardiovascular Medicine, Nippon Medical School , Tokyo, Japan.
authors.forename: Kuniya
authors.initials: K
authors.lastname: Asai
authors.affiliation: Department of Cardiovascular Medicine, Nippon Medical School , Tokyo, Japan.
authors.forename: Wataru
authors.initials: W
authors.lastname: Shimuzu
authors.affiliation: Division of Clinical Genetics, Nippon Medical School , Tokyo, Japan.
authors.forename: Atsushi
authors.initials: A
authors.lastname: Watanabe
authors.affiliation: Diabetes Center, Tokyo Women's Medical University , Tokyo, Japan.
authors.forename: Makiko
authors.initials: M
authors.lastname: Ogata
authors.affiliation: Diabetes Center, Tokyo Women's Medical University , Tokyo, Japan.
authors.forename: Miho
authors.initials: M
authors.lastname: Takizawa
authors.affiliation: Diabetes Center, Tokyo Women's Medical University , Tokyo, Japan.
authors.forename: Risa
authors.initials: R
authors.lastname: Ide
authors.affiliation: Tokyo Women's Medical University Institute of Medical Genetics, Tokyo, Japan; Tokyo Women's Medical University Institute of Integrated Medical Science, Tokyo, Japan.
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Yamamoto
authors.affiliation: Tokyo Women's Medical University Institute of Medical Genetics, Tokyo, Japan; Tokyo Women's Medical University Institute of Integrated Medical Science, Tokyo, Japan.
authors.forename: Kayoko
authors.initials: K
authors.lastname: Saito