title: β-Boswellic acid, a bioactive substance used in food supplements, inhibits protein synthesis by targeting the ribosomal machinery.
abstract: The Boswellia gum resin extracts have been used in traditional medicines because of their remarkable anti-inflammatory properties. Nowadays, these extracts are on the market as food supplements. β-Boswellic acid (βBA) is one of the main pentacyclic triterpene components, among the family of BAs, of the Boswellia gum resins. BAs have been broadly studied and are well known for their wide anti-inflammatory and potential anticancer properties. In this paper, a mass spectrometry-based chemoproteomic approach has been applied to characterize the whole βBA interacting profile. Among the large numbers of proteins fished out, proteasome, 14-3-3 and some ribosomal proteins were considered the most interesting targets strictly connected to the modulation of the cancer progression. In particular, because of their recent assessment as innovative chemotherapeutic targets, the ribosomal proteins were considered the most attractive βBA partners, and the biological role of their interaction with the natural compound has been evaluated. Copyright © 2016 John Wiley & Sons, Ltd.
authors.affiliation: Dipartimento di Farmacia, Università degli Studi di Salerno, Via Giovanni Paolo II, 132, Fisciano, 84084, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Casapullo
authors.affiliation: Dipartimento di Farmacia, Università degli Studi di Salerno, Via Giovanni Paolo II, 132, Fisciano, 84084, Italy.
authors.forename: C
authors.initials: C
authors.lastname: Cassiano
authors.affiliation: Dipartimento di Farmacia, Università degli Studi di Salerno, Via Giovanni Paolo II, 132, Fisciano, 84084, Italy.|PhD Program in Drug Discovery and Development, Università degli studi di Salerno, Via Giovanni Paolo II 132, Fisciano, SA, I-84084, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Capolupo
authors.affiliation: Dipartimento di Farmacia, Università degli Studi di Salerno, Via Giovanni Paolo II, 132, Fisciano, 84084, Italy.|PhD Program in Drug Discovery and Development, Università degli studi di Salerno, Via Giovanni Paolo II 132, Fisciano, SA, I-84084, Italy.|Farmaceutici Damor S.p.A, Via E. Scaglione 27, 80145, Naples, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Del Gaudio
authors.affiliation: Dipartimento di Farmacia, Università degli Studi di Salerno, Via Giovanni Paolo II, 132, Fisciano, 84084, Italy.
authors.forename: R
authors.initials: R
authors.lastname: Esposito
authors.affiliation: Dipartimento di Farmacia, Università degli Studi di Salerno, Via Giovanni Paolo II, 132, Fisciano, 84084, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Tosco
authors.affiliation: Dipartimento di Farmacia, Università degli Studi di Salerno, Via Giovanni Paolo II, 132, Fisciano, 84084, Italy.
authors.forename: R
authors.initials: R
authors.lastname: Riccio
authors.affiliation: Dipartimento di Farmacia, Università degli Studi di Salerno, Via Giovanni Paolo II, 132, Fisciano, 84084, Italy.
authors.forename: M C
authors.initials: MC
authors.lastname: Monti
mesh_terms: D029743:Boswellia / Q000737:chemistry*; D002846:Chromatography, Affinity; D019587:Dietary Supplements / Q000032:analysis*; D055808:Drug Discovery / Q000295:instrumentation*; D006367:HeLa Cells; D006801:Humans; D013058:Mass Spectrometry; D014176:Protein Biosynthesis / Q000187:drug effects; D040901:Proteomics; D012116:Resins, Plant / Q000737:chemistry; D012270:Ribosomes / Q000187:drug effects* / Q000378:metabolism*; D014315:Triterpenes / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*
chemical_list: D012116:Resins, Plant; D014315:Triterpenes; C054625:boswellic acid
keywords: chemical proteomics; food supplements; ribosome; traditional medicine; triterpenes