title: Utilizing on- and off-line monitoring tools to follow a kinetic resolution step during flow synthesis.
abstract: In situ reaction monitoring tools offer the ability to track the progress of a synthetic reaction in real time to facilitate reaction optimization and provide kinetic/mechanistic insight. Herein, we report the utilization of flow NMR, flow IR, and other off-line spectroscopy tools to monitor the progress of a flow chemistry reaction. The on-line and off-line tools were selected to facilitate the stereoselective kinetic resolution of a key racemic monomer, which lacked a chromophore, making conventional reaction monitoring difficult. Copyright © 2016 John Wiley & Sons, Ltd.
authors.affiliation: Medicinal Sciences, Pfizer Worldwide Research and Development, Groton, CT, United States.
authors.forename: Kathleen A
authors.initials: KA
authors.lastname: Farley
authors.affiliation: Medicinal Sciences, Pfizer Worldwide Research and Development, Groton, CT, United States.
authors.forename: Usa
authors.initials: U
authors.lastname: Reilly
authors.affiliation: Medicinal Sciences, Pfizer Worldwide Research and Development, Groton, CT, United States.
authors.forename: Dennis P
authors.initials: DP
authors.lastname: Anderson
authors.affiliation: Medicinal Sciences, Pfizer Worldwide Research and Development, Groton, CT, United States.
authors.forename: Brian P
authors.initials: BP
authors.lastname: Boscoe
authors.affiliation: Medicinal Sciences, Pfizer Worldwide Research and Development, Groton, CT, United States.
authors.forename: Mark W
authors.initials: MW
authors.lastname: Bundesmann
authors.affiliation: Medicinal Sciences, Pfizer Worldwide Research and Development, Groton, CT, United States.
authors.forename: David A
authors.initials: DA
authors.lastname: Foley
authors.affiliation: Medicinal Sciences, Pfizer Worldwide Research and Development, Groton, CT, United States.
authors.forename: Manjinder S
authors.initials: MS
authors.lastname: Lall
authors.affiliation: Medicinal Sciences, Pfizer Worldwide Research and Development, Groton, CT, United States.
authors.forename: Chao
authors.initials: C
authors.lastname: Li
authors.affiliation: Medicinal Sciences, Pfizer Worldwide Research and Development, Groton, CT, United States.
authors.forename: Matthew R
authors.initials: MR
authors.lastname: Reese
authors.affiliation: Medicinal Sciences, Pfizer Worldwide Research and Development, Groton, CT, United States.
authors.forename: Jiangli
authors.initials: J
authors.lastname: Yan
keywords: 1H NMR; enzyme; flow IR; flow NMR; flow synthesis; kinetic resolution; reaction monitoring