title: [Research advances in the role of interleukin-21 in chronic hepatitis B virus infection].
abstract: Interleukin-21 (IL-21) is a cytokine mainly secreted by activated CD4+ T cells and natural killer T cells and has multiple effects. It is involved in innate and adaptive immune responses. Recent studies have shown that IL-21 can promote functional activation of various immune cells in the process of hepatitis B virus (HBV) infection, and the gene polymorphisms of IL-21 is associated with the susceptibility to HBV. In addition, the expression of IL-21 is closely associated with HV genotype, HBV clearance, HBeAg seroconversion, HBV-related liver cirrhosis, liver failure, liver cancer, and autoimmune disease. This article reviews the research advances in clinical trials with reference to the aspects above.
authors.affiliation: Department of Infectious Diseases, Kunming General Hospital of Chengdu Military Command, Kunming 650032, China; Kunming General Hespital Chengdu Military Command, Teaching Hospital of Kunming Medical University, Kunming 650032, China.
authors.forename: R
authors.initials: R
authors.lastname: Ding
authors.affiliation: Department of Infectious Diseases, Kunming General Hospital of Chengdu Military Command, Kunming 650032, China; Department of Infectious Diseases, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
authors.forename: S W
authors.initials: SW
authors.lastname: Ma
mesh_terms: D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D005838:Genotype; D006513:Hepatitis B e Antigens; D006515:Hepatitis B virus / Q000235:genetics; D019694:Hepatitis B, Chronic / Q000276:immunology*; D006801:Humans; D007378:Interleukins / Q000276:immunology*; D008103:Liver Cirrhosis / Q000821:virology; D008113:Liver Neoplasms / Q000821:virology; D008213:Lymphocyte Activation; D055611:Natural Killer T-Cells / Q000276:immunology; D000098546:Interleukin-21
chemical_list: D006513:Hepatitis B e Antigens; D007378:Interleukins; D000098546:Interleukin-21