title: Healthcare Resource Utilisation Associated with Herpes Zoster in a Prospective Cohort of Older Australian Adults.
abstract: BACKGROUND
  Herpes zoster (HZ) is a common condition that increases in incidence with older age but vaccines are available to prevent the disease. However, there are limited data estimating the health system burden attributable to herpes zoster by age.
  
  
  METHODS
  In this study, we quantified excess healthcare resource usage associated with HZ during the acute/sub-acute period of disease (21days before to 90 days after onset) in 5952 cases and an equal number of controls matched on age, sex, and prior healthcare resource usage. Estimates were adjusted for potential confounders in multivariable regression models. Using population-based estimates of HZ incidence, we calculated the age-specific excess number of health service usage events attributable to HZ in the population.
  
  
  RESULTS
  Per HZ case, there was an average of 0.06 (95% CI 0.04-0.08) excess hospitalisations, 1.61 (95% CI 1.51-1.69) excess general practitioner visits, 1.96 (95% CI 1.86-2.15) excess prescriptions filled and 0.11 (95% CI 0.09-0.13) excess emergency department visits. The average number of healthcare resource use events, and the estimated excess per 100,000 population increased with increasing age but were similar for men and women, except for higher rates of hospitalisation in men. The excess annual HZ associated burden of hospitalisations was highest in adults ≥80 years (N = 2244, 95%CI 1719-2767); GP visits was highest in those 60-69 years (N = 50567, 95%CI 39958-61105), prescriptions and ED visits were highest in 70-79 years (N = 50524, 95%CI 40634-60471 and N = 2891, 95%CI 2319-3449 respectively).
  
  
  CONCLUSIONS
  This study provides important data to establish the healthcare utilisation associated with HZ against which detailed cost-effectiveness analyses of HZ immunisation in older adults can be conducted.
authors.affiliation: School of Public Health and Community Medicine, University of New South Wales (UNSW), Sydney, Australia.
authors.forename: Surendra
authors.initials: S
authors.lastname: Karki
authors.affiliation: School of Public Health and Community Medicine, University of New South Wales (UNSW), Sydney, Australia.
authors.forename: Anthony T
authors.initials: AT
authors.lastname: Newall
authors.affiliation: School of Public Health and Community Medicine, University of New South Wales (UNSW), Sydney, Australia.|National Centre for Immunisation Research and Surveillance of Vaccine Preventable Diseases, The Children's Hospital Network, Westmead, NSW, Australia.
authors.forename: C Raina
authors.initials: CR
authors.lastname: MacIntyre
authors.affiliation: School of Public Health and Community Medicine, University of New South Wales (UNSW), Sydney, Australia.
authors.forename: Anita E
authors.initials: AE
authors.lastname: Heywood
authors.affiliation: National Centre for Immunisation Research and Surveillance of Vaccine Preventable Diseases, The Children's Hospital Network, Westmead, NSW, Australia.
authors.forename: Peter
authors.initials: P
authors.lastname: McIntyre
authors.affiliation: National Centre for Epidemiology and Population Health, Australian National University, Canberra, ACT, Australia.|The Sax Institute, Sydney, Australia.
authors.forename: Emily
authors.initials: E
authors.lastname: Banks
authors.affiliation: School of Public Health and Community Medicine, University of New South Wales (UNSW), Sydney, Australia.
authors.forename: Bette
authors.initials: B
authors.lastname: Liu
mesh_terms: D000208:Acute Disease; D000368:Aged; D000369:Aged, 80 and over; D001315:Australia; D016022:Case-Control Studies; D003362:Cost-Benefit Analysis / Q000706:statistics & numerical data*; D003695:Delivery of Health Care / Q000191:economics / Q000706:statistics & numerical data*; D004636:Emergency Service, Hospital / Q000706:statistics & numerical data; D005260:Female; D006562:Herpes Zoster / Q000191:economics* / Q000276:immunology / Q000503:physiopathology / Q000517:prevention & control; D053061:Herpes Zoster Vaccine / Q000008:administration & dosage / Q000191:economics; D014645:Herpesvirus 3, Human / Q000472:pathogenicity / Q000502:physiology; D006760:Hospitalization / Q000191:economics* / Q000706:statistics & numerical data; D006801:Humans; D007114:Immunization / Q000191:economics*; D015994:Incidence; D008297:Male; D008875:Middle Aged
chemical_list: D053061:Herpes Zoster Vaccine