title: Inflammatory Cytokines Interleukin-1β and Tumour Necrosis Factor-α - Novel Biomarkers for the Detection of Periodontal Diseases: a Literature Review.
abstract: OBJECTIVE
  The article aims to discuss the IL-1β and TNF-α potential use as salivary biomarkers of periodontal diseases pathogenesis and progression.
  
  
  METHODS
  This literature review has been registered in PROSPERO database with following number: CRD42016035729. Data investigation was performed on PubMed database as the main source of studies. The following search terms were used: "salivary biomarkers", "periodontal diseases", "TNF-alpha", "Interleukin-1 beta". Clinical trials and animal experimental models of periodontal disease were included in the discussion. In regards to inclusive dates, published studies from January 2006 to December 2015 were considered in this review along with the mentioned inclusion criteria.
  
  
  RESULTS
  IL-1β and TNF-α salivary levels increased in diseased groups, they were associated with onset and disease severity, and their levels reduced in response to periodontal therapy. IL-1β and TNF-α could be promising biomarkers in the detection of periodontal diseases.
  
  
  CONCLUSIONS
  The use of a salivary cytokine-based diagnosis appears to be a screening method capable of diagnosing periodontal diseases in an early fashion, establishing an era of individualized clinical decisions.
authors.affiliation: Faculty of Dentistry, Federal University of Ceará, Sobral, Ceará Brazil.
authors.forename: Francisco Isaac Fernandes
authors.initials: FI
authors.lastname: Gomes
authors.affiliation: Faculty of Dentistry, Federal University of Ceará, Sobral, Ceará Brazil.
authors.forename: Maria Gerusa Brito
authors.initials: MG
authors.lastname: Aragão
authors.affiliation: Faculty of Dentistry, Federal University of Ceará, Sobral, Ceará Brazil.
authors.forename: Francisco Cesar Barroso
authors.initials: FC
authors.lastname: Barbosa
authors.affiliation: Faculty of Medicine, Federal University of Ceará, Sobral, Ceará Brazil.
authors.forename: Mirna Marques
authors.initials: MM
authors.lastname: Bezerra
authors.affiliation: Faculty of Medicine, Federal University of Ceará, Sobral, Ceará Brazil.
authors.forename: Vicente
authors.initials: V
authors.lastname: de Paulo Teixeira Pinto
authors.affiliation: Faculty of Dentistry, Federal University of Ceará, Sobral, Ceará Brazil.
authors.forename: Hellíada Vasconcelos
authors.initials: HV
authors.lastname: Chaves
keywords: TNF-alpha; biological markers; interleukin-1beta; periodontal diseases