title: Rh-Catalyzed [3 + 2] Cycloaddition of 1-Sulfonyl-1,2,3-triazoles: Access to the Framework of Aspidosperma and Kopsia Indole Alkaloids.
abstract: A Rh(II)-catalyzed dearomative intramolecular [3 + 2] dipolar cycloaddition involving the indolic C2-C3 carbon-carbon double bond has been developed. The reaction was launched from the triazole moiety within the substrate and proceeded efficiently under mild conditions. A wide range of functional groups could be tolerated. These features render the current reaction a highly useful tool for the synthesis of polycyclic indole alkaloids, as showcased by a rapid assembly of the core structure of Aspidosperma and the related alkaloids.
authors.affiliation: State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engeneering, Lanzhou University , Lanzhou 730000, China.|State Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences , 345 Lingling Road, Shanghai 200032, China.
authors.forename: Yun
authors.initials: Y
authors.lastname: Li
authors.affiliation: State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engeneering, Lanzhou University , Lanzhou 730000, China.
authors.forename: Qingyu
authors.initials: Q
authors.lastname: Zhang
authors.affiliation: State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engeneering, Lanzhou University , Lanzhou 730000, China.
authors.forename: Qiucheng
authors.initials: Q
authors.lastname: Du
authors.affiliation: State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engeneering, Lanzhou University , Lanzhou 730000, China.|Laboratory of Chemical Genomics, School of Chemical Biology and Biotechnology, Shenzhen Graduate School of Peking University , Shenzhen 518055, China.
authors.forename: Hongbin
authors.initials: H
authors.lastname: Zhai