title: Genetics and metabolic deregulation following cancer initiation: A world to explore.
abstract: Cancer is a group of highly complex and heterogeneous diseases with several causes. According to the stochastic model, cancer initiates from mutation in somatic cells, leading to genomic instability and cell transformation. This canonical pathway of carcinogenesis is related to the discovery of important mechanisms that regulate cancer initiation. However, there are few studies describing genetic and metabolic alterations that deregulate transformed cells, resulting in epithelial-mesenchymal transition (EMT) and its most dramatic consequence, the metastasis. This review summarizes the main genetics and metabolic changes induced by reactive oxygen species (ROS) that lead to EMT.
authors.affiliation: Laboratório de Genética, Instituto Butantan, Brazil; Programa de Pós-graduação Interunidades em Biotecnologia, Instituto de Ciências Biomédicas (ICB), Universidade de São Paulo (USP), Brazil.
authors.forename: Rodrigo Pinheiro
authors.initials: RP
authors.lastname: Araldi
authors.affiliation: Laboratório de Genética, Instituto Butantan, Brazil.
authors.forename: Diego Grando
authors.initials: DG
authors.lastname: Módolo
authors.affiliation: Laboratório de Genética, Instituto Butantan, Brazil.
authors.forename: Paulo Luiz
authors.initials: PL
authors.lastname: de Sá Júnior
authors.affiliation: Departamento de Bioquímica e Biologia Tecidual, Instituto de Biologia (IB), Universidade Estadual de Campinas (UNICAMP), Brazil.
authors.forename: Sílvio Roberto
authors.initials: SR
authors.lastname: Consonni
authors.affiliation: Laboratório de Genética, Instituto Butantan, Brazil.
authors.forename: Rodrigo Franco
authors.initials: RF
authors.lastname: de Carvalho
authors.affiliation: Dipartimento di Medicina Veterinaria e Produzioni Animali, Università degli Studi di Napoli Federico II, Italy.
authors.forename: Franco Peppino
authors.initials: FP
authors.lastname: Roperto
authors.affiliation: Laboratório de Genética, Instituto Butantan, Brazil.
authors.forename: Willy
authors.initials: W
authors.lastname: Beçak
authors.affiliation: Laboratório de Genética, Instituto Butantan, Brazil. Electronic address: rita.stocco@butantan.gov.br.
authors.forename: Rita
authors.initials: R
authors.lastname: de Cassia Stocco
mesh_terms: D000818:Animals; D063646:Carcinogenesis / Q000235:genetics* / Q000378:metabolism*; D004734:Energy Metabolism; D058750:Epithelial-Mesenchymal Transition; D006801:Humans; D009362:Neoplasm Metastasis; D017382:Reactive Oxygen Species / Q000378:metabolism; D015290:Second Messenger Systems
chemical_list: D017382:Reactive Oxygen Species
keywords: Epithelial–mesenchymal transition; Oncogenesis; Oncogenic viruses; ROS