title: Risk factors for new-onset diabetes mellitus after living donor kidney transplantation in Korea - a retrospective single center study.
abstract: New-onset diabetes mellitus after transplantation (NODAT) is a serious complication following renal transplantation. The aim of this study was to identify the risk factors for the development of NODAT in Korean transplant patients.
  
  
  
  Recipients who underwent living donor kidney transplantation between January 2009 and April 2012 at Asan Medical Center were reviewed. Diagnosis of NODAT was defined according to the American Diabetes Association criteria.
  
  
  
  A total of 418 patients were enrolled. NODAT was diagnosed in 85 (20.4 %) patients within 1 year. By multivariate analysis, old age (odds ratio [OR], 1.05; 95 % Confidence interval [CI]: 1.01-1.08), family history of diabetes mellitus (OR, 2.48; 95 % CI: 1.04-5.94), pre-transplant high serum glucose level (OR, 1.04; 95 % CI: 1.01-1.08), and obesity (OR, 3.46; 95 % CI: 1.55-7.73) were independent risk factors for NODAT.
  
  
  
  Old age, family history of diabetes, pre-transplant high plasma glucose level, and obesity are independent factors associated with the development of diabetes after renal transplantation. In contrast, serum magnesium levels and the use of tacrolimus are not associated with the development of NODAT.
authors.affiliation: Division of a Nephrology, Gangneung Asan hospital, University of Ulsan College of Medicine, Gangneung, South Korea.
authors.forename: Hoon
authors.initials: H
authors.lastname: Yu
authors.affiliation: Division of a Nephrology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea.
authors.forename: Hyosang
authors.initials: H
authors.lastname: Kim
authors.affiliation: Division of a Nephrology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea.
authors.forename: Chung Hee
authors.initials: CH
authors.lastname: Baek
authors.affiliation: Division of a Nephrology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea.
authors.forename: Seung Don
authors.initials: SD
authors.lastname: Baek
authors.affiliation: Division of a Nephrology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea.
authors.forename: Soomin
authors.initials: S
authors.lastname: Jeung
authors.affiliation: Department of Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea.
authors.forename: Duck Jong
authors.initials: DJ
authors.lastname: Han
authors.affiliation: Division of a Nephrology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea. skpark@amc.seoul.kr.
authors.forename: Su-Kil
authors.initials: SK
authors.lastname: Park
mesh_terms: D000328:Adult; D000367:Age Factors; D001786:Blood Glucose / Q000378:metabolism; D003920:Diabetes Mellitus / Q000453:epidemiology* / Q000209:etiology* / Q000235:genetics; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D016030:Kidney Transplantation / Q000009:adverse effects*; D019520:Living Donors; D008274:Magnesium / Q000097:blood; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000453:epidemiology; D057234:Preoperative Period; D056910:Republic of Korea / Q000453:epidemiology; D012189:Retrospective Studies; D012307:Risk Factors; D016559:Tacrolimus / Q000627:therapeutic use
chemical_list: D001786:Blood Glucose; D007166:Immunosuppressive Agents; D008274:Magnesium; D016559:Tacrolimus
keywords: Diabetes mellitus; Kidney Transplantation; Magnesium; Tacrolimus