title: Downregulation of miR-145-5p correlates with poor prognosis in gastric cancer.
abstract: The aim of this study was to explore the clinical significance of miR-145-5p expression in gastric cancer (GC).
  
  
  
  Expression of miR-145-5p was evaluated by qRT- PCR in tumor and normal gastric tissues in 145 GC patients. The correlation between the miR-145-5p expression and clinicopathological parameters was investigated. Finally, the survival was assessed by the Kaplan-Meier method and proportional hazards model.
  
  
  
  Expression levels of miR-145-5p in GC tissues were significantly lower than those in adjacent normal tissues (p < 0.001). MiR-145-5p expression was significantly associated with lymph node metastasis, metastasis stage, and distant metastasis (all p < 0.05). Furthermore, Patients with low miR-145-5p expression had poorer overall survival time than those with high miR-145-5p expression (p = 0.014). Moreover, univariate and multivariate Cox analysis showed that miR-145-5p was an independent prognostic indicator for OS (p = 0.011).
  
  
  
  MiR-145-5p is down-expressed in GC, and can be used as a marker of poor prognosis in GC patients.
authors.affiliation: Department of Oncology, Heping Hospital, Changzhi Medical College, Changzhi, Shanxi, P.R. China. weiw5m@sina.com.
authors.forename: Y
authors.initials: Y
authors.lastname: Zhang
authors.forename: X
authors.initials: X
authors.lastname: Wen
authors.forename: X-L
authors.initials: XL
authors.lastname: Hu
authors.forename: L-Z
authors.initials: LZ
authors.lastname: Cheng
authors.forename: J-Y
authors.initials: JY
authors.lastname: Yu
authors.forename: Z-B
authors.initials: ZB
authors.lastname: Wei
mesh_terms: D014408:Biomarkers, Tumor / Q000235:genetics; D015536:Down-Regulation; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D035683:MicroRNAs / Q000235:genetics / Q000378:metabolism; D011379:Prognosis; D013274:Stomach Neoplasms / Q000235:genetics*
chemical_list: D014408:Biomarkers, Tumor; D035683:MicroRNAs