title: [Mesenchymal stem/stroma cells : Therapeutic potential in the treatment of autoimmune diseases].
abstract: Mesenchymal stem and stromal cells (MSC) are propagated for the treatment of autoimmune and autoinflammatory processes. These cells can be relatively easily obtained from various tissues. The MSC feature anti-inflammatory and immunosuppressive properties in vitro as well as in animal models. Initial reports on the clinical application of MSC for various diseases are available, some with promising results and so far no reported toxicity; however, data from phase III studies are still lacking and crucial questions are still unanswered. The MSC preparations used are heterogeneous and also differ depending on the source and it is unclear whether autologous (own) or allogeneic (foreign) MSC are more suitable for therapeutic use. Long-term consequences, such as possible malignant transformation and possible endogenous tumor growth stimulation cannot be completely excluded. Ultimately, these questions can only be answered through randomized controlled trials for defined clinical indications with defined MSC.
authors.affiliation: Institut für Transfusionsmedizin und Immunhämatologie, DRK Blutspendedienst Baden-Württemberg-Hessen GmbH, Klinikum der Goethe Universität, Sandhofstr. 1, 60528, Frankfurt/Main, Deutschland.
authors.forename: R
authors.initials: R
authors.lastname: Schäfer
authors.affiliation: Rheumatologische Klinik, Universitätsspital Basel, Petersgraben 4, 4031, Basel, Schweiz. thomas.daikeler@usb.ch.
authors.forename: T
authors.initials: T
authors.lastname: Daikeler
mesh_terms: D001327:Autoimmune Diseases / Q000175:diagnosis* / Q000628:therapy*; D019317:Evidence-Based Medicine; D006801:Humans; D045164:Mesenchymal Stem Cell Transplantation / Q000009:adverse effects* / Q000379:methods*; D011230:Precancerous Conditions / Q000209:etiology* / Q000517:prevention & control; D012219:Rheumatology / Q000639:trends; D016896:Treatment Outcome
keywords: Immunomodulation; Immunosuppression; Systemic lupus erythematosus; Systemic sclerosis; Transplantation