title: Adsorption and desorption behaviors of cetylpyridinium chloride on hydroxyapatite nanoparticles with different morphologies.
abstract: Application of hydroxyapatite (HAp) nanoparticles to repair damaged enamel has attracted recent attention. In this study, HAp nanoparticles with various morphologies (spherical, short-rod, long-rod and fiber morphologies) were synthesized via chemical precipitation methods without the addition of template molecules, and the adsorption/desorption behaviors of a cationic antibacterial agent, cetylpyridinium chloride (CPC), on the HAp nanoparticles were evaluated. The adsorption of CPC on each HAp nanoparticle showed Langmuir-type adsorption, and the short-rod/long-rod HAp nanoparticles showed thermodynamically more stable adsorption of CPC than that with the spherical/fiber HAp nanoparticles. The desorption rate of CPC from the short-rod/long-rod HAp nanoparticles was slower than that of the spherical/fiber HAp nanoparticles. The HAp nanoparticles with different CPC release profiles presented here have potential applications as nanoparticulate enamel repair agents with antibacterial properties.
authors.affiliation: Department of Biomaterials, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University.
authors.forename: Masahiro
authors.initials: M
authors.lastname: Okada
authors.forename: Daisuke
authors.initials: D
authors.lastname: Hiramatsu
authors.forename: Takumi
authors.initials: T
authors.lastname: Okihara
authors.forename: Takuya
authors.initials: T
authors.lastname: Matsumoto
mesh_terms: D000327:Adsorption; D002594:Cetylpyridinium; D003743:Dental Enamel; D017886:Durapatite; D053758:Nanoparticles
chemical_list: D017886:Durapatite; D002594:Cetylpyridinium