title: Copper-catalyzed oxyamination of electron-deficient alkenes with N-acyloxyamines.
abstract: A Cu(i)-catalyzed direct intermolecular oxyamination of electron deficient alkenes is disclosed. This process is characterized by difunctionalization of a variety of α,β-unsaturated ketones with easily available N-acyloxyamine reagents as both amine and oxygen donors, which delivers ester derivatives of β-amino alcohols in good yields as well as with high regioselectivity. Control studies suggested the involvement of alkyl radical species on the way of product formation.
authors.affiliation: Department of Chemistry, University of Science and Technology of China, Hefei, Anhui 230026, P. R. China and Institute of Advanced Synthesis, College of Chemistry and Molecular Engineering, Jiangsu National Synergetic Innovation Center for Advanced Materials, Nanjing Tech University, Nanjing, Jiangsu 210009, P. R. China. iamcfeng@njtech.edu.cn.
authors.forename: Shichao
authors.initials: S
authors.lastname: Ren
authors.affiliation: Department of Chemistry, University of Science and Technology of China, Hefei, Anhui 230026, P. R. China and Institute of Advanced Synthesis, College of Chemistry and Molecular Engineering, Jiangsu National Synergetic Innovation Center for Advanced Materials, Nanjing Tech University, Nanjing, Jiangsu 210009, P. R. China. iamcfeng@njtech.edu.cn.
authors.forename: Shengjin
authors.initials: S
authors.lastname: Song
authors.affiliation: Institute of Advanced Synthesis, College of Chemistry and Molecular Engineering, Jiangsu National Synergetic Innovation Center for Advanced Materials, Nanjing Tech University, Nanjing, Jiangsu 210009, P. R. China. iamcfeng@njtech.edu.cn.
authors.forename: Lu
authors.initials: L
authors.lastname: Ye
authors.affiliation: Institute of Advanced Synthesis, College of Chemistry and Molecular Engineering, Jiangsu National Synergetic Innovation Center for Advanced Materials, Nanjing Tech University, Nanjing, Jiangsu 210009, P. R. China. iamcfeng@njtech.edu.cn.
authors.forename: Chao
authors.initials: C
authors.lastname: Feng
authors.affiliation: Department of Chemistry, University of Science and Technology of China, Hefei, Anhui 230026, P. R. China and Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore 637371, Singapore. teckpeng@ntu.edu.sg.
authors.forename: Teck-Peng
authors.initials: TP
authors.lastname: Loh