title: What Happens When Underperforming Big Ideas in Research Become Entrenched?
authors.affiliation: Laboratory of Human Integrative Physiology and Department of Anesthesiology, Mayo Clinic, Rochester, Minnesota.
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Joyner
authors.affiliation: Departments of Epidemiology and Biostatistics and Pediatrics and Human Development, College of Human Medicine, Michigan State University, East Lansing.
authors.forename: Nigel
authors.initials: N
authors.lastname: Paneth
authors.affiliation: Stanford Prevention Research Center, Department of Medicine and Meta-Research Innovation Center at Stanford, Stanford University, Stanford, California.
authors.forename: John P A
authors.initials: JP
authors.lastname: Ioannidis
mesh_terms: D035843:Biomedical Research / Q000191:economics / Q000592:standards*; D004194:Disease / Q000235:genetics; D057286:Electronic Health Records / Q000191:economics; D015316:Genetic Therapy / Q000706:statistics & numerical data; D014644:Genetic Variation; D006801:Humans; D058990:Molecular Targeted Therapy; D009316:National Institutes of Health (U.S.); D009369:Neoplasms / Q000235:genetics / Q000628:therapy; D057285:Precision Medicine / Q000592:standards / Q000639:trends; D039781:PubMed / Q000706:statistics & numerical data; D011643:Publishing / Q000706:statistics & numerical data / Q000639:trends; D012109:Research Support as Topic; D033581:Stem Cell Transplantation; D014481:United States