title: [Expression of major histocompatibility complex class Ⅰ chain-related protein A and B in operable lung adenocarcinoma and its clinical significance].
abstract: OBJECTIVE
  To explore the expression of major histocompatibility complex classⅠchain-related protein A and B (MICA/B) in operable lung adenocarcinoma and its clinical significance.
  
  
  METHODS
  Between January 2002 and December 2003, 100 patients with operable lung adenocarcinoma in People's Hospital of Zhengzhou were collected. The expression of MICA/B was examined by immunohistochemistry staining.According to immunohistochemical staining, the cases with score ≥5 points were high expression of MICA/B while <5 points were low expression of MICA/B.Chi-square test was utilized to analyze the relationship between MICA/B expression and clinicopathologic features. The association between MICA/B protein and overall survival in the patients with operable lung adenocarcinoma was analyzed by Kaplan-Meier survival curve, together with Log-Rank test. The COX regression model was established to analyze the single and combined effects of these covariants.
  
  
  RESULTS
  The percentage with high expression of MICA/B protein in operable lung adenocarcinoma tissue was 38% (38/100). The over-expression rate of MICA/B protein in the group with mutant epidermal growth factor receptor (EGFR) gene was significantly higher than that in the group with wild EGFR gene (93.8% vs 11.8%, P<0.001). No statistical significance was observed between the expression of MICA/B protein and other clinicopathologic parameters, including age, sex, TNM stage, T- staging, histological grade and lymph node metastasis. Kaplan-Meier analysis showed that overexpression of MICA/B protein was closely associated with shorter survival time (10.4 vs 28.9 months, P=0.005).
  
  
  CONCLUSIONS
  Overexpression of MICA/B in operable lung adenocarcinoma tissue is closely related to the mutations of EGFR and overall survival, which may be a poor prognosis indicator in patients with operable lung adenocarcinoma.
authors.affiliation: Department of Oncology, the People's Hospital of Zhengzhou, Zhengzhou 450003, China.
authors.forename: J Z
authors.initials: JZ
authors.lastname: Zhao
authors.forename: J Z
authors.initials: JZ
authors.lastname: Mei
authors.forename: W
authors.initials: W
authors.lastname: Song
authors.forename: G J
authors.initials: GJ
authors.lastname: Liu
authors.forename: R T
authors.initials: RT
authors.lastname: Feng
mesh_terms: D000230:Adenocarcinoma; D000077192:Adenocarcinoma of Lung; D066246:ErbB Receptors; D015395:Histocompatibility Antigens Class I; D006801:Humans; D007150:Immunohistochemistry; D053208:Kaplan-Meier Estimate; D008175:Lung Neoplasms; D008207:Lymphatic Metastasis
chemical_list: D015395:Histocompatibility Antigens Class I; C099187:MHC class I-related chain A; C098080:MICB antigen; C512478:EGFR protein, human; D066246:ErbB Receptors