title: Evaluation of Dogs with Border Collie Collapse, Including Response to Two Standardized Strenuous Exercise Protocols.
abstract: Clinical and metabolic variables were evaluated in 13 dogs with border collie collapse (BCC) before, during, and following completion of standardized strenuous exercise protocols. Six dogs participated in a ball-retrieving protocol, and seven dogs participated in a sheep-herding protocol. Findings were compared with 16 normal border collies participating in the same exercise protocols (11 retrieving, five herding). Twelve dogs with BCC developed abnormal mentation and/or an abnormal gait during evaluation. All dogs had post-exercise elevations in rectal temperature, pulse rate, arterial blood pH, PaO2, and lactate, and decreased PaCO2 and bicarbonate, as expected with strenuous exercise, but there were no significant differences between BCC dogs and normal dogs. Electrocardiography demonstrated sinus tachycardia in all dogs following exercise. Needle electromyography was normal, and evaluation of muscle biopsy cryosections using a standard panel of histochemical stains and reactions did not reveal a reason for collapse in 10 dogs with BCC in which these tests were performed. Genetic testing excluded the dynamin-1 related exercise-induced collapse mutation and the V547A malignant hyperthermia mutation as the cause of BCC. Common reasons for exercise intolerance were eliminated. Although a genetic basis is suspected, the cause of collapse in BCC was not determined.
authors.affiliation: From the Department of Small Animal Clinical Sciences (S.T., C.S., L.S.) and the Department of Large Animal Clinical Sciences (T.E.), Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, Canada; the University of Minnesota, Minneapolis, MN (K.M., J.M., E.P.); and the Comparative Neuromuscular Laboratory, Department of Pathology, University of California-San Diego, La Jolla, CA (G.D.S.).
authors.forename: Susan
authors.initials: S
authors.lastname: Taylor
authors.affiliation: From the Department of Small Animal Clinical Sciences (S.T., C.S., L.S.) and the Department of Large Animal Clinical Sciences (T.E.), Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, Canada; the University of Minnesota, Minneapolis, MN (K.M., J.M., E.P.); and the Comparative Neuromuscular Laboratory, Department of Pathology, University of California-San Diego, La Jolla, CA (G.D.S.).
authors.forename: Cindy
authors.initials: C
authors.lastname: Shmon
authors.affiliation: From the Department of Small Animal Clinical Sciences (S.T., C.S., L.S.) and the Department of Large Animal Clinical Sciences (T.E.), Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, Canada; the University of Minnesota, Minneapolis, MN (K.M., J.M., E.P.); and the Comparative Neuromuscular Laboratory, Department of Pathology, University of California-San Diego, La Jolla, CA (G.D.S.).
authors.forename: Lillian
authors.initials: L
authors.lastname: Su
authors.affiliation: From the Department of Small Animal Clinical Sciences (S.T., C.S., L.S.) and the Department of Large Animal Clinical Sciences (T.E.), Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, Canada; the University of Minnesota, Minneapolis, MN (K.M., J.M., E.P.); and the Comparative Neuromuscular Laboratory, Department of Pathology, University of California-San Diego, La Jolla, CA (G.D.S.).
authors.forename: Tasha
authors.initials: T
authors.lastname: Epp
authors.affiliation: From the Department of Small Animal Clinical Sciences (S.T., C.S., L.S.) and the Department of Large Animal Clinical Sciences (T.E.), Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, Canada; the University of Minnesota, Minneapolis, MN (K.M., J.M., E.P.); and the Comparative Neuromuscular Laboratory, Department of Pathology, University of California-San Diego, La Jolla, CA (G.D.S.).
authors.forename: Katie
authors.initials: K
authors.lastname: Minor
authors.affiliation: From the Department of Small Animal Clinical Sciences (S.T., C.S., L.S.) and the Department of Large Animal Clinical Sciences (T.E.), Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, Canada; the University of Minnesota, Minneapolis, MN (K.M., J.M., E.P.); and the Comparative Neuromuscular Laboratory, Department of Pathology, University of California-San Diego, La Jolla, CA (G.D.S.).
authors.forename: James
authors.initials: J
authors.lastname: Mickelson
authors.affiliation: From the Department of Small Animal Clinical Sciences (S.T., C.S., L.S.) and the Department of Large Animal Clinical Sciences (T.E.), Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, Canada; the University of Minnesota, Minneapolis, MN (K.M., J.M., E.P.); and the Comparative Neuromuscular Laboratory, Department of Pathology, University of California-San Diego, La Jolla, CA (G.D.S.).
authors.forename: Edward
authors.initials: E
authors.lastname: Patterson
authors.affiliation: From the Department of Small Animal Clinical Sciences (S.T., C.S., L.S.) and the Department of Large Animal Clinical Sciences (T.E.), Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, Canada; the University of Minnesota, Minneapolis, MN (K.M., J.M., E.P.); and the Comparative Neuromuscular Laboratory, Department of Pathology, University of California-San Diego, La Jolla, CA (G.D.S.).
authors.forename: G Diane
authors.initials: GD
authors.lastname: Shelton
mesh_terms: D000818:Animals; D001786:Blood Glucose; D001831:Body Temperature; D002245:Carbon Dioxide / Q000097:blood; D003402:Creatine Kinase / Q000097:blood; D004283:Dog Diseases / Q000235:genetics / Q000628:therapy*; D004285:Dogs; D005260:Female; D006339:Heart Rate; D006863:Hydrogen-Ion Concentration; D019344:Lactic Acid / Q000097:blood; D008297:Male; D018482:Muscle, Skeletal / Q000502:physiology; D009154:Mutation; D010100:Oxygen / Q000097:blood; D010805:Physical Conditioning, Animal; D019289:Pyruvic Acid / Q000097:blood; D019837:Ryanodine Receptor Calcium Release Channel / Q000235:genetics / Q000378:metabolism
chemical_list: D001786:Blood Glucose; D019837:Ryanodine Receptor Calcium Release Channel; D002245:Carbon Dioxide; D019344:Lactic Acid; D019289:Pyruvic Acid; D003402:Creatine Kinase; D010100:Oxygen