title: [Diabetes mellitus and bone].
abstract: It has been shown that diabetic patients have bone fragility independent of bone mineral density. Recently, diabetes-related bone disease is recognized as one of diabetic complications. It is reported that advanced glycation end products(AGEs)collagen cross-links, low bone turnover with osteoblastic dysfunction, and abnormality of microarchitectures such as cortical porosity and deterioration of trabecular bone structure are involved in diabetes-related bone disease. AGEs and homocysteine directly and negatively affect osteoblasts and osteocytes. Moreover, anti-diabetic drugs also affect bone metabolism. Therefore, the underlying mechanisms are very complex. In this review, we describe the effects of diabetes on bone metabolism based on the recent evidence.
authors.affiliation: Internal Medicine 1, Shimane University Faculty of Medicine, Japan.
authors.forename: Ippei
authors.initials: I
authors.lastname: Kanazawa
authors.affiliation: Internal Medicine 1, Shimane University Faculty of Medicine, Japan.
authors.forename: Toshitsugu
authors.initials: T
authors.lastname: Sugimoto
mesh_terms: D000818:Animals; D015519:Bone Density; D001842:Bone and Bones / Q000378:metabolism* / Q000503:physiopathology; D048909:Diabetes Complications; D003920:Diabetes Mellitus / Q000378:metabolism*; D050723:Fractures, Bone / Q000209:etiology; D017127:Glycation End Products, Advanced / Q000378:metabolism; D006710:Homocysteine / Q000378:metabolism; D006801:Humans
chemical_list: D017127:Glycation End Products, Advanced; D006710:Homocysteine