title: Quantitative structure property relationship modeling of excipient properties for prediction of formulation characteristics.
abstract: Quantitative structure property relationship (QSPR) is used to relate the excipient descriptors with the formulation properties. A QSPR model is developed by regression analysis of selected descriptors contributing towards the targeted formulation properties. Developed QSPR model is validated by the true external method where it showed good accuracy and precision in predicting the formulation composition as experimental t90% (61.35min) is observed very close to predicted t90% (67.37min). Hence, QSPR approach saves resources by predicting drug release from an unformulated formulation; avoiding repetitive trials in the development of a new formulation and/or optimization of existing one.
authors.affiliation: Department of Pharmaceutics, P.E. Society's Modern College of Pharmacy, Nigdi, Pune 411044, Maharashtra, India. Electronic address: vinod_gaikwad29@yahoo.com.
authors.forename: Vinod L
authors.initials: VL
authors.lastname: Gaikwad
authors.affiliation: Department of Pharmaceutical Chemistry, Bharati Vidyapeeth College of Pharmacy, Kolhapur 416013, Maharashtra, India. Electronic address: neelabhatia@yahoo.co.uk.
authors.forename: Neela M
authors.initials: NM
authors.lastname: Bhatia
authors.affiliation: Department of Pharmaceutical Chemistry, Bharati Vidyapeeth College of Pharmacy, Kolhapur 416013, Maharashtra, India. Electronic address: sujitdesai37@gmail.com.
authors.forename: Sujit A
authors.initials: SA
authors.lastname: Desai
authors.affiliation: Department of Pharmaceutical Chemistry, Bharati Vidyapeeth College of Pharmacy, Kolhapur 416013, Maharashtra, India. Electronic address: drmsbhatia13@gmail.com.
authors.forename: Manish S
authors.initials: MS
authors.lastname: Bhatia
mesh_terms: D004337:Drug Carriers / Q000737:chemistry; D004339:Drug Compounding; D065546:Drug Liberation; D005079:Excipients / Q000737:chemistry* / Q000494:pharmacology*; D007700:Kinetics; D008962:Models, Theoretical; D021281:Quantitative Structure-Activity Relationship; D012044:Regression Analysis
chemical_list: D004337:Drug Carriers; D005079:Excipients
keywords: Dissolution; Drug release kinetic; Excipient; Mathematical modelling; Quantitative-structure property relationship