title: Autoimmune Hepatitis and Seronegative Hepatitis Associated With Myelodysplastic Syndrome in Children.
abstract: An association between hepatitis and aplastic anemia (AA) is known as hepatitis-associated AA, and is characterized by an acute attack of hepatitis followed by the development of AA. We report 2 clinical cases of acute seronegative hepatitis in which pancytopenia with mild dysplasia developed after 3 months; however, neither of our cases fulfilled the histological criteria of AA, but rather myelodysplastic syndrome. This novel association bears considerable resemblance to hepatitis-associated AA, and raises the question of whether hepatitis-associated dysmyelopoiesis should be included in the spectrum of hypocellular myelodysplastic syndrome.
authors.affiliation: Departments of *Pediatrics †Pediatric Hepatology ‡Pathology §Pediatric Hematology and Oncology, Aarhus University Hospital, Aarhus, Denmark.
authors.forename: Line K
authors.initials: LK
authors.lastname: Rasmussen
authors.forename: Elisabeth V
authors.initials: EV
authors.lastname: Stenbøg
authors.forename: Gitte B
authors.initials: GB
authors.lastname: Kerndrup
authors.forename: Henrik
authors.initials: H
authors.lastname: Hasle
mesh_terms: D000741:Anemia, Aplastic; D002648:Child; D003937:Diagnosis, Differential; D006505:Hepatitis / Q000150:complications*; D019693:Hepatitis, Autoimmune / Q000150:complications*; D006801:Humans; D008297:Male; D009190:Myelodysplastic Syndromes / Q000209:etiology*; D010198:Pancytopenia