title: Toward an operational neuroethical risk analysis and mitigation paradigm for emerging neuroscience and technology (neuroS/T).
abstract: Research in neuroscience and neurotechnology (neuroS/T) is progressing at a rapid pace with translational applications both in medicine, and more widely in the social milieu. Current and projected neuroS/T research and its applications evoke a number of neuroethicolegal and social issues (NELSI). This paper defines inherent and derivative NELSI of current and near-term neuroS/T development and engagement, and provides an overview of our group's ongoing work to develop a systematized approach to their address. Our proposed operational neuroethical risk assessment and mitigation paradigm (ONRAMP) is presented, which entails querying, framing, and modeling patterns and trajectories of neuroS/T research and translational uses, and the NELSI generated by such advancements and their applications. Extant ethical methods are addressed, with suggestion toward possible revision or re-formulation to meet the needs and exigencies fostered by neuroS/T and resultant NELSI in multi-cultural contexts. The relevance and importance of multi-disciplinary expertise in focusing upon NELSI is discussed, and the need for neuroethics education toward cultivating such a cadre of expertise is emphasized.
authors.affiliation: Neuroethics Studies Program, Pellegrino Center for Clinical Bioethics, Georgetown University Medical Center, 4000 Reservoir Road, Bldg. D, Rm. 238, Washington, DC 20057, USA; Department of Neurology, Georgetown University Medical Center, 4000 Reservoir Road, Bldg. D, Rm. 238, Washington, DC 20057, USA. Electronic address: james.giordano@georgetown.edu.
authors.forename: James
authors.initials: J
authors.lastname: Giordano
mesh_terms: D020811:Biomedical Technology / Q000941:ethics* / Q000331:legislation & jurisprudence; D003198:Computer Simulation; D032984:Ethics, Research; D006077:Government Agencies; D006801:Humans; D062069:Inventions / Q000941:ethics; D009488:Neurosciences / Q000941:ethics* / Q000331:legislation & jurisprudence; D018570:Risk Assessment; D012940:Social Problems; D006113:United Kingdom; D014481:United States