title: Bone Marrow Metastases from a 1p/19q Co-deleted Oligodendroglioma - A Case Report.
abstract: BACKGROUND
  Metastasis of oligodendroglioma outside of the central nervous system (CNS) is a very rare event.
  
  
  METHODS
  We describe in detail the clinical story of a 50-year-old woman diagnosed with profound pancytopenia and signs of extramedullary hematopoiesis caused by diffuse bone marrow replacement by a metastatic oligodendroglioma.
  
  
  RESULTS
  Upon development of pancytopenia, a diagnostic bone marrow examination revealed the presence of metastatic oligodendroglial cells. No others sites of malignant dissemination were found outside the CNS. Despite best supportive care, the patient died three weeks after diagnosis of myelophthisis.
  
  
  CONCLUSIONS
  Extracranial metastases from CNS oligodendroglioma are a very rare event but can be the cause of bone marrow failure.
authors.affiliation: Department of Medical Oncology, UZ Brussel, Brussels, Belgium.
authors.forename: Marieke
authors.initials: M
authors.lastname: Demeulenaere
authors.affiliation: Department of Neurosurgery, UZ Brussel, Brussels, Belgium.
authors.forename: Johnny
authors.initials: J
authors.lastname: Duerinck
authors.affiliation: Department of Neurosurgery, UZ Brussel, Brussels, Belgium.
authors.forename: Stephanie
authors.initials: S
authors.lastname: DU Four
authors.affiliation: Department of Hematology, UZ Brussel, Brussels, Belgium.
authors.forename: Karel
authors.initials: K
authors.lastname: Fostier
authors.affiliation: Department of Neurology and Neuropathology, UZ Brussel, Brussels, Belgium.
authors.forename: Alex
authors.initials: A
authors.lastname: Michotte
authors.affiliation: Department of Medical Oncology, UZ Brussel, Brussels, Belgium Bart.Neyns@uzbrussel.be.
authors.forename: Bart
authors.initials: B
authors.lastname: Neyns
mesh_terms: D000328:Adult; D019046:Bone Marrow Neoplasms / Q000000981:diagnostic imaging* / Q000556:secondary; D001932:Brain Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology; D002872:Chromosome Deletion; D002878:Chromosomes, Human, Pair 1 / Q000235:genetics; D002888:Chromosomes, Human, Pair 19 / Q000235:genetics; D017809:Fatal Outcome; D005260:Female; D005625:Frontal Lobe / Q000473:pathology; D006801:Humans; D009837:Oligodendroglioma / Q000000981:diagnostic imaging* / Q000556:secondary
keywords: 1p/19q co-deletion; bone marrow metastases; oligodendroglioma