title: Protective Effect of Troxerutin on Nickel-Induced Testicular Toxicity in Wistar Rats.
abstract: Nickel (Ni)-induced oxidative damage is a serious problem that leads to reproductive system failure through testicular damage. The present investigation was carried out to determine the effect of troxerutin (Txn) on testicular toxicity induced by Ni in experimental rat testes. The oral administration of Txn (100 mg/kg body weight [bw]) showed a significant (p < 0.01) increase in superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), glutathione-S-transferase (GST), glutathione reductase (GR), glucose-6-phosphate dehydrogenase (G6PD), reduced glutathione, ascorbate, total sulphydryl groups, and testis-organ weight. Subsequently, the administration of Txn also significantly reduced the accumulation of Ni, lipid peroxidation products, and protein carbonyl levels in Txn-treated animals. Testicular protection in the experimental animals by Txn is further substantiated by a remarkable reduction of Ni, which was revealed through testicular tissue histopathology. These studies suggest that Txn could prevent oxidative damage and testicular toxicity induced by Ni in experimental animals.
authors.affiliation: Department of Biochemistry and Biotechnology, Faculty of Science, Annamalai University, Annamalai Nagar 608002, Tamil Nadu, India.
authors.forename: Perumal
authors.initials: P
authors.lastname: Elangovan
authors.affiliation: Department of Biochemistry and Biotechnology, Faculty of Science, Annamalai University, Annamalai Nagar 608002, Tamil Nadu, India.
authors.forename: Abdulkadhar Mohamed
authors.initials: AM
authors.lastname: Jalaludeen
authors.affiliation: Department of Biochemistry and Biotechnology, Faculty of Science, Annamalai University, Annamalai Nagar 608002, Tamil Nadu, India.
authors.forename: Ramalingam
authors.initials: R
authors.lastname: Ramakrishnan
authors.affiliation: Department of Biochemistry and Biotechnology, Faculty of Science, Annamalai University, Annamalai Nagar 608002, Tamil Nadu, India.
authors.forename: Leelavinothan
authors.initials: L
authors.lastname: Pari
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000378:metabolism* / Q000627:therapeutic use; D002462:Cell Membrane / Q000187:drug effects / Q000201:enzymology; D056486:Chemical and Drug Induced Liver Injury / Q000188:drug therapy / Q000517:prevention & control*; D006896:Hydroxyethylrutoside / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use; D008297:Male; D009532:Nickel / Q000633:toxicity*; D018384:Oxidative Stress / Q000187:drug effects*; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D013737:Testis / Q000187:drug effects* / Q000201:enzymology
chemical_list: D000975:Antioxidants; D006896:Hydroxyethylrutoside; C029938:nickel sulfate; D009532:Nickel; C005865:troxerutin