title: The diagnosis and management of the haematologic manifestations of lupus.
abstract: Haematological manifestations in systemic lupus erythematosus (SLE) are frequently observed. They are diverse and range from mild to severe. Therefore, different treatment approaches are needed from simply keeping vigilant to significant immunosuppression. Most treatment evidence is based on case-reports or small retrospective studies, as few randomized controlled trials have been performed. The development of biological therapy has opened new possible ways to treat the most severe cases but further clinical trials are necessary. In this review we consider the most common and characteristic haematological manifestations of SLE patients, focusing on their pathogenesis and management.
authors.affiliation: Internal Medicine Department, University Hospital Complex of Pontevedra, Pontevedra, Spain. Electronic address: alba.velo@gmail.com.
authors.forename: Alba
authors.initials: A
authors.lastname: Velo-García
authors.affiliation: Autoimmune Diseases Unit, Internal Medicine 7.2 Department, Hospital Curry Cabral, Centro Hospitalar Lisboa Central, Lisbon, Portugal. Electronic address: saragcastro@gmail.com.
authors.forename: Sara Guerreiro
authors.initials: SG
authors.lastname: Castro
authors.affiliation: Department of Rheumatology, University College London, UK. Electronic address: d.isenberg@ucl.ac.uk.
authors.forename: David A
authors.initials: DA
authors.lastname: Isenberg
mesh_terms: D000740:Anemia / Q000175:diagnosis / Q000209:etiology / Q000378:metabolism / Q000628:therapy; D000744:Anemia, Hemolytic, Autoimmune / Q000175:diagnosis / Q000209:etiology / Q000378:metabolism / Q000628:therapy; D019468:Disease Management; D006487:Hemostasis; D006801:Humans; D007970:Leukopenia / Q000175:diagnosis / Q000209:etiology / Q000378:metabolism / Q000628:therapy; D008180:Lupus Erythematosus, Systemic / Q000097:blood* / Q000150:complications / Q000175:diagnosis* / Q000628:therapy; D010641:Phenotype; D013921:Thrombocytopenia / Q000175:diagnosis / Q000209:etiology / Q000378:metabolism / Q000628:therapy
keywords: Anaemia; Leukopaenia; Systemic lupus erythematosus; Thrombocytopaenia