title: Suitable intravenous fluid for preventing dysnatremia in children with gastroenteritis; a randomized clinical trial.
abstract: BACKGROUND
  Gastroenteritis (GE) is one of the most common pediatric diseases. Hyponatremia commonly occurs by administering hypotonic fluids to GE and hospitalized children. Yet, there is no consensus on the ideal method of treatment.
  
  
  OBJECTIVE
  we aimed to assess suitable intravenous (IV) fluid for preventing dysnatremia in children with GE.
  
  
  METHODS
  This is a double blind randomized clinical trial, which was conducted on infants of 6 months up to 14 years children with GE. Children were randomly assigned in 2 different groups. Group A; received 20 cc/kg 0.9% isotonic saline as a bolus, and 0.45% hypotonic saline as sum of maintenance fluid and volume deficit. Group B was treated with the same bolus and 0.9% isotonic saline with 20 mEq/L KCl as sum of maintenance fluid and volume deficit. Blood and urine samples were taken at admission, 4 and 24 hours. Data were analyzed by independent t test, Mann-Whitney U test, Friedmann test, chi-square and 2-tailed repeated measurements by SPSS version 19.
  
  
  RESULTS
  Baseline hyponatremia and isonatremia were detected in 24 (31.5%) and 51 (67.1%) patients, respectively. Mean level of sodium at T0, T4 and T 24 mentioned no significant difference between groups. No hypernatremia was noted by administering isotonic saline. RESULTS showed that 4 and 24 hours after administration isotonic saline, the mean plasma sodium differed significantly in baseline hyponatremic patients. However, no significant difference was noted after 4 and 24 hours in group A.
  
  
  CONCLUSIONS
  According to the considerable effect of isotonic saline on hyponatremic patients, it seems that administering isotonic fluids regardless of the types of dysnatremia can be recommended to lessen clinicians' conflicting decision-making in selecting an appropriate fluid.
authors.affiliation: Pediatrics Growth Disorders Research Center, 17 Shahrivar Hospital, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran.
authors.forename: Kioomars
authors.initials: K
authors.lastname: Golshekan
authors.affiliation: Pediatrics Growth Disorders Research Center, 17 Shahrivar Hospital, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran.
authors.forename: Hamidreza
authors.initials: H
authors.lastname: Badeli
authors.affiliation: Pediatrics Growth Disorders Research Center, 17 Shahrivar Hospital, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran.
authors.forename: Mahboube
authors.initials: M
authors.lastname: Miri
authors.affiliation: Pediatrics Growth Disorders Research Center, 17 Shahrivar Hospital, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran.
authors.forename: Maryam
authors.initials: M
authors.lastname: Mirzaie
authors.affiliation: Pediatrics Growth Disorders Research Center, 17 Shahrivar Hospital, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran.
authors.forename: Afagh
authors.initials: A
authors.lastname: Hassanzadeh Rad
authors.affiliation: Chancellorship for Research, Guilan University of Medical Sciences, Rasht, Iran.
authors.forename: Fatemeh
authors.initials: F
authors.lastname: Salamat
authors.affiliation: Pediatrics Growth Disorders Research Center, 17 Shahrivar Hospital, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran.
authors.forename: Sepideh
authors.initials: S
authors.lastname: Abdi Tazeabadi
authors.affiliation: Pediatrics Growth Disorders Research Center, 17 Shahrivar Hospital, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran.
authors.forename: Nahid
authors.initials: N
authors.lastname: Bidar
authors.affiliation: Pediatrics Growth Disorders Research Center, 17 Shahrivar Hospital, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran.
authors.forename: Kobra
authors.initials: K
authors.lastname: Blouki-Moghaddam
authors.affiliation: Pediatrics Growth Disorders Research Center, 17 Shahrivar Hospital, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran.
authors.forename: Houman
authors.initials: H
authors.lastname: Hashemian
keywords: Children; Gastroenteritis; Hypernatremia; Hyponatremia