title: Self-assembly of fully addressable DNA nanostructures from double crossover tiles.
abstract: DNA origami and single-stranded tile (SST) are two proven approaches to self-assemble finite-size complex DNA nanostructures. The construction elements appeared in structures from these two methods can also be found in multi-stranded DNA tiles such as double crossover tiles. Here we report the design and observation of four types of finite-size lattices with four different double crossover tiles, respectively, which, we believe, in terms of both complexity and robustness, will be rival to DNA origami and SST structures.
authors.affiliation: School of Life Sciences, Tsinghua University-Peking University Center for Life Sciences, Center for Synthetic and Systems Biology, Tsinghua University, Beijing 100084, China Bioengineering Graduate Program, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong Depatment of Chemistry, Tongji University, Shanghai 200092, China.
authors.forename: Wen
authors.initials: W
authors.lastname: Wang
authors.affiliation: School of Life Sciences, Tsinghua University-Peking University Center for Life Sciences, Center for Synthetic and Systems Biology, Tsinghua University, Beijing 100084, China.
authors.forename: Tong
authors.initials: T
authors.lastname: Lin
authors.affiliation: School of Life Sciences, Tsinghua University-Peking University Center for Life Sciences, Center for Synthetic and Systems Biology, Tsinghua University, Beijing 100084, China.
authors.forename: Suoyu
authors.initials: S
authors.lastname: Zhang
authors.affiliation: School of Life Sciences, Tsinghua University-Peking University Center for Life Sciences, Center for Synthetic and Systems Biology, Tsinghua University, Beijing 100084, China.
authors.forename: Tanxi
authors.initials: T
authors.lastname: Bai
authors.affiliation: Bioengineering Graduate Program, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong Depatment of Chemistry, Tongji University, Shanghai 200092, China Department of Chemical and Biomolecular Engineering, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong keymix@ust.hk.
authors.forename: Yongli
authors.initials: Y
authors.lastname: Mi
authors.affiliation: School of Life Sciences, Tsinghua University-Peking University Center for Life Sciences, Center for Synthetic and Systems Biology, Tsinghua University, Beijing 100084, China bw@tsinghua.edu.cn.
authors.forename: Bryan
authors.initials: B
authors.lastname: Wei
mesh_terms: D004247:DNA / Q000737:chemistry*; D018625:Microscopy, Atomic Force; D049329:Nanostructures / Q000737:chemistry*; D009690:Nucleic Acid Conformation
chemical_list: D004247:DNA