title: Microinjection of the melanin-concentrating hormone into the sublaterodorsal tegmental nucleus inhibits REM sleep in the rat.
abstract: A study was performed on the effects of local microinjection of melanin-concentrating hormone (MCH) into the right sublaterodorsal tegmental nucleus (SLD) on sleep and wakefulness in rats prepared for chronic sleep recordings. MCH 200ng significantly decreased rapid-eye-movement sleep (REMS) time during the first and second 2-h of the recording period which was related to the reduction of the number of REMS periods and the increase of REMS latency. It is proposed that REMS inhibition was related to the direct deactivation of SLD glutamatergic neurons by the peptide.
authors.affiliation: Department of Pharmacology and Therapeutics, School of Medicine Clinics Hospital, University of the Republic, Montevideo 11600, Uruguay. Electronic address: jmonti@mednet.org.uy.
authors.forename: Jaime M
authors.initials: JM
authors.lastname: Monti
authors.affiliation: Department of Physiology, School of Medicine, University of the Republic, Montevideo 11300, Uruguay.
authors.forename: Pablo
authors.initials: P
authors.lastname: Torterolo
authors.affiliation: Department of Pharmacology and Therapeutics, School of Medicine Clinics Hospital, University of the Republic, Montevideo 11600, Uruguay.
authors.forename: Héctor
authors.initials: H
authors.lastname: Jantos
authors.affiliation: Department of Physiology, School of Medicine, University of the Republic, Montevideo 11300, Uruguay.
authors.forename: Patricia
authors.initials: P
authors.lastname: Lagos
mesh_terms: D000818:Animals; D004569:Electroencephalography; D007028:Hypothalamic Hormones / Q000008:administration & dosage* / Q000502:physiology*; D008297:Male; D008543:Melanins / Q000008:administration & dosage* / Q000502:physiology*; D008845:Microinjections; D009474:Neurons / Q000502:physiology; D009778:Occipital Lobe / Q000502:physiology; D010907:Pituitary Hormones / Q000008:administration & dosage* / Q000502:physiology*; D051381:Rats; D017208:Rats, Wistar; D012895:Sleep, REM; D013681:Tegmentum Mesencephali / Q000502:physiology*; D014851:Wakefulness
chemical_list: D007028:Hypothalamic Hormones; D008543:Melanins; D010907:Pituitary Hormones; C019463:melanin-concentrating hormone
keywords: Glutamate; Melanin-concentrating hormone; REM sleep; Sleep; Sublaterodorsal tegmental nucleus