title: Insulin Resistance and Obesity Affect Lipid Profile in the Salivary Glands.
abstract: In today's world wrong nutritional habits together with a low level of physical activity have given rise to the development of obesity and its comorbidity, insulin resistance. More specifically, many researches indicate that lipids are vitally involved in the onset of a peripheral tissue (e.g., skeletal muscle, heart, and liver) insulin resistance. Moreover, it seems that diabetes can also induce changes in respect of lipid composition of both the salivary glands and saliva. However, judging by the number of research articles, the salivary glands lipid profile still has not been sufficiently explored. In the current study we aim to assess the changes in the main lipid fractions, namely, triacylglycerols, phospholipids, free fatty acids, and diacylglycerols, in the parotid and the submandibular salivary glands of rats exposed to a 5-week high fat diet regimen. We observed that the high caloric fat diet caused a significant change in the salivary glands lipid composition, especially with respect to PH and TG, but not DAG or FFAs, classes. The observed reduction in PH concentration is an interesting phenomenon frequently signifying the atrophy and malfunctions in the saliva secreting organs. On the other hand, the increased accumulation of TG in the glands may be an important clinical manifestation of metabolic syndrome and type 2 diabetes mellitus.
authors.affiliation: County Veterinary Inspection, 26B Zwycięstwa Street, 15-959 Białystok, Poland.
authors.forename: Jan
authors.initials: J
authors.lastname: Matczuk
authors.affiliation: Department of Conservative Dentistry, Medical University of Bialystok, 1 Kilińskiego Street, 15-222 Białystok, Poland.
authors.forename: Anna
authors.initials: A
authors.lastname: Zalewska
authors.affiliation: Department of Physiology, Medical University of Bialystok, 2C Mickiewicza Street, 15-222 Białystok, Poland.
authors.forename: Bartłomiej
authors.initials: B
authors.lastname: Łukaszuk
authors.affiliation: Institute of Health Care Higher Vocational School, 10 Noniewicza Street, 16-400 Suwałki, Poland.
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Knaś
authors.affiliation: Students' Scientific Group "Stomatological Biochemistry", Department of Conservative Dentistry, Medical University of Bialystok, 1 Kilińskiego Street, 15-222 Białystok, Poland.
authors.forename: Mateusz
authors.initials: M
authors.lastname: Maciejczyk
authors.affiliation: Department of Hygiene, Epidemiology and Ergonomics, Medical University of Bialystok, 2C Mickiewicza Street, 15-222 Białystok, Poland.
authors.forename: Marta
authors.initials: M
authors.lastname: Garbowska
authors.affiliation: Department of Public Health, Medical University of Bialystok, 1 Kilińskiego Street, 15-222 Białystok, Poland.
authors.forename: Dominika M
authors.initials: DM
authors.lastname: Ziembicka
authors.affiliation: Department of Conservative Dentistry, Medical University of Bialystok, 1 Kilińskiego Street, 15-222 Białystok, Poland.
authors.forename: Danuta
authors.initials: D
authors.lastname: Waszkiel
authors.affiliation: Department of Physiology, Medical University of Bialystok, 2C Mickiewicza Street, 15-222 Białystok, Poland.
authors.forename: Adrian
authors.initials: A
authors.lastname: Chabowski
authors.affiliation: Department of Hygiene, Epidemiology and Ergonomics, Medical University of Bialystok, 2C Mickiewicza Street, 15-222 Białystok, Poland.
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Żendzian-Piotrowska
authors.affiliation: Department of Physiology, Medical University of Bialystok, 2C Mickiewicza Street, 15-222 Białystok, Poland.
authors.forename: Krzysztof
authors.identifier: 0000-0003-4927-4304
authors.initials: K
authors.lastname: Kurek
mesh_terms: D000818:Animals; D059305:Diet, High-Fat; D004075:Diglycerides / Q000378:metabolism*; D005230:Fatty Acids, Nonesterified / Q000378:metabolism*; D007333:Insulin Resistance; D008297:Male; D009765:Obesity / Q000378:metabolism*; D010306:Parotid Gland / Q000378:metabolism*; D010743:Phospholipids / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D012469:Salivary Glands / Q000378:metabolism; D013363:Submandibular Gland / Q000378:metabolism*; D014280:Triglycerides / Q000378:metabolism*
chemical_list: D004075:Diglycerides; D005230:Fatty Acids, Nonesterified; D010743:Phospholipids; D014280:Triglycerides