title: Post renal transplant pure red cell aplasia-is tacrolimus a culprit?
abstract: Anemia is not uncommon in the post-renal transplant period and has been reported in up to 40% of renal transplant recipients. It is commonly due to drugs and infections. While post-transplantation anemia is usually due to graft dysfunction and drugs such as mycophenolate and cotrimoxazole, tacrolimus is an uncommon cause. Tacrolimus is usually not believed to be significantly myelosuppressive, but it can cause anemia due to thrombotic microangiopathy. A literature review shows a very small number of reported cases of pure red cell aplasia (PRCA) where tacrolimus seemed to be a causative agent. We report a case series of three renal transplant recipients who were on tacrolimus and presented with chronic transfusion requiring anemia due to PRCA.
authors.affiliation: Department of Nephrology , IPGME&R SSKM Hospital , Kolkata-20 , India.
authors.forename: Malagouda R
authors.initials: MR
authors.lastname: Patil
authors.affiliation: Department of Nephrology , IPGME&R SSKM Hospital , Kolkata-20 , India.
authors.forename: Arpita Roy
authors.initials: AR
authors.lastname: Choudhury
authors.affiliation: Department of Nephrology , IPGME&R SSKM Hospital , Kolkata-20 , India.
authors.forename: Manong
authors.initials: M
authors.lastname: Chohwanglim
authors.affiliation: Department of Nephrology , IPGME&R SSKM Hospital , Kolkata-20 , India.
authors.forename: Smita
authors.initials: S
authors.lastname: Divyaveer
authors.affiliation: Department of Nephrology , IPGME&R SSKM Hospital , Kolkata-20 , India.
authors.forename: Chetan
authors.initials: C
authors.lastname: Mahajan
authors.affiliation: Department of Nephrology , IPGME&R SSKM Hospital , Kolkata-20 , India.
authors.forename: Rajendra
authors.initials: R
authors.lastname: Pandey
keywords: anemia; hemoglobin; pure red cell aplasia; tacrolimus; transplantation