title: EFFECT OF ε-AMINOCAPROIC ACID ON FIBRINOLYSIS IN PLASMA OF ASIAN ELEPHANTS (ELEPHAS MAXIMUS).
abstract: ε-Aminocaproic acid (EACA) is a lysine analogue antifibrinolytic drug used to treat bleeding disorders in humans and domestic animals. Use in zoological medicine is rare and dose recommendations are anecdotal, but EACA may be a valuable therapeutic option for bleeding disorders in exotic species, including Asian elephants ( Elephas maximus ). This study used an in vitro model of hyperfibrinolysis and a thromboelastograph-based assay to estimate the therapeutic plasma concentration of EACA in Asian elephants (61.5 μg/ml, 95% CI = 34.6-88.5 μg/ml). Substantial but incomplete inhibition of lysis was seen at relatively low concentrations of EACA (40 μg/ml). Asian elephants appear sensitive to EACA-mediated inhibition of hyperfibrinolysis. Doses published for domestic animals, targeting higher plasma concentrations, may be inappropriate in this species.
authors.forename: Sarrah
authors.initials: S
authors.lastname: Kaye
authors.forename: Noha
authors.initials: N
authors.lastname: Abou-Madi
authors.forename: Daniel J
authors.initials: DJ
authors.lastname: Fletcher
mesh_terms: D015119:Aminocaproic Acid / Q000494:pharmacology*; D000818:Animals; D000933:Antifibrinolytic Agents / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004606:Elephants / Q000097:blood*; D005260:Female; D005342:Fibrinolysis / Q000187:drug effects*; D008297:Male; D013916:Thrombelastography / Q000662:veterinary
chemical_list: D000933:Antifibrinolytic Agents; D015119:Aminocaproic Acid
keywords: Asian elephant; Elephas maximus; fibrinolysis; thromboelastography; ε-aminocaproic acid