title: Effect of micronized progesterone on fetal-placental volume in first-trimester threatened abortion.
abstract: OBJECTIVE
  To compare the effect of oral micronized progesterone (OMP) on the first-trimester fetal and placental volumes using three-dimensional ultrasonography and extended imaging virtual organ computer-aided analysis (XI VOCAL) method in threatened abortion.
  
  
  METHODS
  This randomized controlled trial enrolled women with threatened abortion and a singleton pregnancy from 6-8 6/7 weeks of gestation. A total of 60 women with threatened abortion were randomly assigned to one of two groups: OMP (400 mg/day) (n = 30) and control groups (n = 30). The XI VOCAL method was used for all volume measurements using three-dimensional ultrasonography. All patients were evaluated for fetal, amniotic, and placental volumes during the initial diagnosis and after 4 weeks.
  
  
  RESULTS
  After treatment, placental volume difference was significantly higher in the OMP group (336%, 67-1,077) than in the control group (141%, 29-900) (p = 0.007). The mean differences in gestational sac, amniotic sac, and embryonic volumes between the OMP and control groups were not statistically significant.
  
  
  CONCLUSIONS
  Hormonal support with OMP is associated with increased placental volume in first-trimester threatened abortion when compared with the control group. © 2016 Wiley Periodicals, Inc. J Clin Ultrasound 45:14-19, 2017.
authors.affiliation: Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, Hacettepe University Faculty of Medicine, Ankara, Turkey.
authors.forename: Mert
authors.initials: M
authors.lastname: Turgal
authors.affiliation: Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, Hacettepe University Faculty of Medicine, Ankara, Turkey.
authors.forename: Emine
authors.initials: E
authors.lastname: Aydin
authors.affiliation: Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, Hacettepe University Faculty of Medicine, Ankara, Turkey.
authors.forename: Ozgur
authors.initials: O
authors.lastname: Ozyuncu
mesh_terms: D000033:Abortion, Threatened / Q000000981:diagnostic imaging / Q000188:drug therapy*; D000284:Administration, Oral; D000328:Adult; D005260:Female; D047109:Fetal Development / Q000187:drug effects*; D006801:Humans; D021621:Imaging, Three-Dimensional; D009929:Organ Size / Q000187:drug effects; D010920:Placenta / Q000033:anatomy & histology / Q000000981:diagnostic imaging / Q000187:drug effects*; D011247:Pregnancy; D011261:Pregnancy Trimester, First; D011374:Progesterone / Q000494:pharmacology* / Q000627:therapeutic use; D011372:Progestins / Q000494:pharmacology* / Q000627:therapeutic use; D011446:Prospective Studies; D016896:Treatment Outcome; D016216:Ultrasonography, Prenatal
chemical_list: D011372:Progestins; D011374:Progesterone
keywords: XI-VOCAL; obstetrics; threatened abortion; three-dimensional ultrasonography; volume measurement