title: Sound tuning of amygdala plasticity in auditory fear conditioning.
abstract: Various auditory tones have been used as conditioned stimuli (CS) for fear conditioning, but researchers have largely neglected the effect that different types of auditory tones may have on fear memory processing. Here, we report that at lateral amygdala (LA) synapses (a storage site for fear memory), conditioning with different types of auditory CSs (2.8 kHz tone, white noise, FM tone) recruits distinct forms of long-term potentiation (LTP) and inserts calcium permeable AMPA receptor (CP-AMPAR) for variable periods. White noise or FM tone conditioning produced brief insertion (<6 hr after conditioning) of CP-AMPARs, whereas 2.8 kHz tone conditioning induced more persistent insertion (≥6 hr). Consistently, conditioned fear to 2.8 kHz tone but not to white noise or FM tones was erased by reconsolidation-update (which depends on the insertion of CP-AMPARs at LA synapses) when it was performed 6 hr after conditioning. Our data suggest that conditioning with different auditory CSs recruits distinct forms of LA synaptic plasticity, resulting in more malleable fear memory to some tones than to others.
authors.affiliation: School of Biological Sciences, College of Natural Sciences, Seoul National University, 1 Gwanangno, Seoul 08826, Korea.
authors.forename: Sungmo
authors.initials: S
authors.lastname: Park
authors.affiliation: School of Biological Sciences, College of Natural Sciences, Seoul National University, 1 Gwanangno, Seoul 08826, Korea.
authors.forename: Junuk
authors.initials: J
authors.lastname: Lee
authors.affiliation: School of Biological Sciences, College of Natural Sciences, Seoul National University, 1 Gwanangno, Seoul 08826, Korea.
authors.forename: Kyungjoon
authors.initials: K
authors.lastname: Park
authors.affiliation: Center for Neuroscience and Center for Functional Connectomics, Korea Institute of Science and Technology, Seoul 136791, Korea.
authors.forename: Jeongyeon
authors.initials: J
authors.lastname: Kim
authors.affiliation: Institute of Neuroscience, Technical University of Munich, 80333, Germany.
authors.forename: Beomjong
authors.initials: B
authors.lastname: Song
authors.affiliation: The Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.
authors.forename: Ingie
authors.initials: I
authors.lastname: Hong
authors.affiliation: Ewha Brain Institute, Ewha W. University, Seoul, Korea.|Department of Brain and Cognitive Sciences, Scranton College, Ewha W. University, Seoul, Korea.
authors.forename: Jieun
authors.initials: J
authors.lastname: Kim
authors.affiliation: Department of Neural Development and Disease, Korea Brain Research Institute, Daegu, Korea.
authors.forename: Sukwon
authors.initials: S
authors.lastname: Lee
authors.affiliation: School of Biological Sciences, College of Natural Sciences, Seoul National University, 1 Gwanangno, Seoul 08826, Korea.
authors.forename: Sukwoo
authors.initials: S
authors.lastname: Choi
mesh_terms: D000161:Acoustic Stimulation; D000679:Amygdala / Q000502:physiology*; D000818:Animals; D003213:Conditioning, Psychological; D005239:Fear / Q000502:physiology*; D066298:In Vitro Techniques; D017774:Long-Term Potentiation; D008297:Male; D009473:Neuronal Plasticity; D018408:Patch-Clamp Techniques; D051381:Rats; D017207:Rats, Sprague-Dawley; D018091:Receptors, AMPA / Q000378:metabolism; D013016:Sound
chemical_list: D018091:Receptors, AMPA