title: Group A rotavirus gastroenteritis: post-vaccine era, genotypes and zoonotic transmission.
abstract: ABSTRACTThis article provides a review of immunity, diagnosis, and clinical aspects of rotavirus disease. It also informs about the changes in epidemiology of diarrheal disease and genetic diversity of circulating group A rotavirus strains following the introduction of vaccines. Group A rotavirus is the major pathogen causing gastroenteritis in animals. Its segmented RNA genome can lead to the emergence of new or unusual strains in human populations via interspecies transmission and/or reassortment events.RESUMOEste artigo fornece uma revisão sobre imunidade, diagnóstico e aspectos clínicos da doença causada por rotavírus. Também aponta as principais mudanças no perfil epidemiológico da doença diarreica e na diversidade genética das cepas circulantes de rotavírus do grupo A, após a introdução vacinal. O rotavírus do grupo A é o principal patógeno associado à gastroenterite em animais. Seu genoma RNA segmentado pode levar ao surgimento de cepas novas ou incomuns na população humana, por meio de transmissão entre espécies e eventos de rearranjo.
authors.affiliation: Instituto Adolfo Lutz, São Paulo, SP, Brazil.
authors.forename: Adriana
authors.initials: A
authors.lastname: Luchs
authors.affiliation: Instituto Adolfo Lutz, São Paulo, SP, Brazil.
authors.forename: Maria do Carmo Sampaio Tavares
authors.initials: Mdo C
authors.lastname: Timenetsky
mesh_terms: D000818:Animals; D001938:Brazil / Q000453:epidemiology; D003967:Diarrhea / Q000821:virology; D005759:Gastroenteritis / Q000276:immunology / Q000628:therapy / Q000662:veterinary / Q000821:virology*; D014644:Genetic Variation; D005838:Genotype; D006801:Humans; D012401:Rotavirus / Q000235:genetics / Q000472:pathogenicity / Q000502:physiology; D012400:Rotavirus Infections / Q000503:physiopathology / Q000628:therapy / Q000635:transmission / Q000662:veterinary; D022243:Rotavirus Vaccines / Q000276:immunology / Q000627:therapeutic use; D015047:Zoonoses / Q000635:transmission / Q000821:virology
chemical_list: D022243:Rotavirus Vaccines