title: Antibacterial and Antifungal Activities of Lectin Extracted from Fruiting Bodies of the Korean Cauliflower Medicinal Mushroom, Sparassis latifolia (Agaricomycetes).
abstract: In this article we describe the isolation and characterization of a novel lectin from fruiting bodies of the mushroom Sparassis latifolia. The antibacterial activity of the purified lectin against Escherichia coli and resistant strains of Staphylococcus aureus and Pseudomonas aeruginosa as well as the antifungal activity against Candida and Fusarium species were determined. Circular dichroism spectroscopy and the tryptophan blue shift assay indicated that the lectin interacts with microbial surfaces. This suggests the potential of the lectin isolated from S. latifolia, a valuable source of bioactive constituents, as a therapeutic in pharmaceutical agent.
authors.affiliation: Department of Biochemical and Polymer Engineering, Chosun University, Gwangju, Korea.
authors.forename: Gayathri
authors.initials: G
authors.lastname: Chandrasekaran
authors.affiliation: Department of BioNano Technology, Gachon University, Seongnam-si, Gyeonggi-do, Korea.
authors.forename: Young-Chul
authors.initials: YC
authors.lastname: Lee
authors.affiliation: Korea Forest Research Institute, Seoul, Korea.
authors.forename: Hyun
authors.initials: H
authors.lastname: Park
authors.affiliation: Department of Biochemical and Polymer Engineering, Chosun University, Gwangju, Korea.
authors.forename: Yuanzheng
authors.initials: Y
authors.lastname: Wu
authors.affiliation: Department of Biochemical and Polymer Engineering, Chosun University, Gwangju, Korea.
authors.forename: Hyun-Jae
authors.initials: HJ
authors.lastname: Shin
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D000935:Antifungal Agents / Q000302:isolation & purification / Q000494:pharmacology*; D001487:Basidiomycota / Q000737:chemistry*; D045424:Complex Mixtures; D004926:Escherichia coli / Q000187:drug effects; D048690:Fruiting Bodies, Fungal / Q000737:chemistry*; D037102:Lectins / Q000302:isolation & purification / Q000494:pharmacology*; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D013211:Staphylococcus aureus / Q000187:drug effects
chemical_list: D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D045424:Complex Mixtures; D037102:Lectins