title: Multi-functional lectin-like transcript-1: A new player in human immune regulation.
abstract: Lectins and C-type lectins are a heterogeneous group of proteins with a diverse range of functions. Two C-type lectins, found in the Natural Killer gene Complex (NKC), Lectin-like transcript 1 (LLT1) and CD161, have recently gained interest from a broad range of immunological and non-immunological fields. LLT1 in particular has a diverse functional repertoire, from NK cell and B cell regulation to bone metabolism. This review seeks to bring together nearly two decades of research on these receptors and describe their importance in the immune system.
authors.affiliation: Peter Medawar Building for Pathogen Research, University of Oxford, Oxford, UK. Electronic address: alba.llibre@ndm.ox.ac.uk.
authors.forename: Alba
authors.initials: A
authors.lastname: Llibre
authors.affiliation: Peter Medawar Building for Pathogen Research, University of Oxford, Oxford, UK; Oxford NIHR Biomedical Research Centre, Oxford OX3 9DU, UK.
authors.forename: Paul
authors.initials: P
authors.lastname: Klenerman
authors.affiliation: Peter Medawar Building for Pathogen Research, University of Oxford, Oxford, UK; Oxford NIHR Biomedical Research Centre, Oxford OX3 9DU, UK. Electronic address: chris.willberg@ndm.ox.ac.uk.
authors.forename: Christian B
authors.initials: CB
authors.lastname: Willberg
mesh_terms: D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology*; D001842:Bone and Bones / Q000378:metabolism*; D006801:Humans; D007109:Immunity; D056747:Immunomodulation; D007694:Killer Cells, Natural / Q000276:immunology*; D037181:Lectins, C-Type / Q000276:immunology*; D055651:NK Cell Lectin-Like Receptor Subfamily B / Q000276:immunology*; D010012:Osteogenesis; D011956:Receptors, Cell Surface / Q000276:immunology*
chemical_list: C400041:CLEC2D protein, human; C527203:KLRB1 protein, human; D037181:Lectins, C-Type; D055651:NK Cell Lectin-Like Receptor Subfamily B; D011956:Receptors, Cell Surface
keywords: C-type lectin-like receptors; Carbohydrate recognition domain; Lectin-like transcript 1; Natural killer gene complex; Osteoclast inhibitory lectin