title: The role of human papillomavirus in head and neck cancer and the impact on radiotherapy outcome.
abstract: CONCLUSIONS
  HPV + HNSCC patients have improved Overall Survival (OS), Disease Specific Survival (DSS), Disease Free Survival (DFS), and Progression Free Survival (PFS). The radiotherapy treatment can't improve the Survival of the HPV-negative HNSCC patients.
  
  
  OBJECTIVE
  To investigate the role of Human papillomavirus in head and neck cancer and the impact on radiotherapy outcome.
  
  
  METHODS
  A search in PubMed and Chinese CNKI (2000-2015) was performed. This meta-analysis was done using RevMan 5.1 software. Outcomes included OS, DSS, DFS, PFS, and Treatment responses rates (RR).
  
  
  RESULTS
  A total of 2620 patients in 10 studies were included. The Positive detective rates of HPV and P16 are 32.5% (425/1309) and 42.5% (526/1239). OS and PFS were improved in HPV + patients compared to HPV - patients (HR = 0.48; 95% CI = 0.37-0.62, p < 0.0001) and (HR = 0.49; 95% CI = 0.31-0.78, p < 0.0001). The survival benefit was similar in HPV-16 + patients (adjusted HR = 0.39; 95% CI = 0.21-0.60, p < 0.0001). The DFS of P16 + patients improved (HR = 0.70; 95% CI = 0.55-0.89, p < 0.0001). The treatment response of p16 + patients didn't significantly improve compared with p16- patients (HR = 1.44; 95% CI = 1.01-2.05, p = 0.05).
authors.affiliation: a Department of Otolaryngology-Head and Neck Surgery , First Affiliated Hospital of Zhengzhou University , Zhengzhou , Henan , PR China.
authors.forename: Xiaoyuan
authors.initials: X
authors.lastname: Zhu
authors.affiliation: a Department of Otolaryngology-Head and Neck Surgery , First Affiliated Hospital of Zhengzhou University , Zhengzhou , Henan , PR China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Wang
authors.affiliation: a Department of Otolaryngology-Head and Neck Surgery , First Affiliated Hospital of Zhengzhou University , Zhengzhou , Henan , PR China.
authors.forename: Honghai
authors.initials: H
authors.lastname: Zhu
authors.affiliation: a Department of Otolaryngology-Head and Neck Surgery , First Affiliated Hospital of Zhengzhou University , Zhengzhou , Henan , PR China.
authors.forename: Weihua
authors.initials: W
authors.lastname: Lou
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000401:mortality / Q000532:radiotherapy / Q000821:virology*; D018572:Disease-Free Survival; D006258:Head and Neck Neoplasms / Q000401:mortality / Q000532:radiotherapy / Q000821:virology*; D006801:Humans; D030361:Papillomavirus Infections / Q000150:complications*; D016896:Treatment Outcome
keywords: Head and neck cancer; human papillomavirus; radiotherapy