title: Liquid-Infused Poly(styrene-b-isobutylene-b-styrene) Microfiber Coating Prevents Bacterial Attachment and Thrombosis.
abstract: Infection and thrombosis associated with medical implants cause significant morbidity and mortality worldwide. As we know, current technologies to prevent infection and thrombosis may cause severe side effects. To overcome these complications without using antimicrobial and anticoagulant drugs, we attempt to prepare a liquid-infused poly(styrene-b-isobutylene-b-styrene) (SIBS) microfiber coating, which can be directly coated onto medical devices. Notably, the SIBS microfiber was fabricated through solution blow spinning. Compared to electrospinning, the solution blow spinning method is faster and less expensive, and it is easy to spray fibers onto different targets. The lubricating liquids then wick into and strongly adhere the microfiber coating. These slippery coatings can effectively suppress blood cell adhesion, reduce hemolysis, and inhibit blood coagulation in vitro. In addition, Pseudomonas aeruginosa (P. aeruginosa) on the lubricant infused coatings slides readily, and no visible residue is left after tilting. We furthermore confirm that the lubricants have no effects on bacterial growth. The slippery coatings are also not cytotoxic to L929 cells. This liquid-infused SIBS microfiber coating could reduce the infection and thrombosis of medical devices, thus benefiting human health.
authors.affiliation: School of Polymer Science and Engineering, Qingdao University of Science and Technology , Qingdao 266042, People's Republic of China.|State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences , Changchun 130022, People's Republic of China.
authors.forename: Shuaishuai
authors.initials: S
authors.lastname: Yuan
authors.affiliation: School of Polymer Science and Engineering, Qingdao University of Science and Technology , Qingdao 266042, People's Republic of China.
authors.forename: Zhibo
authors.initials: Z
authors.lastname: Li
authors.affiliation: State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences , Changchun 130022, People's Republic of China.
authors.forename: Lingjie
authors.initials: L
authors.lastname: Song
authors.affiliation: State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences , Changchun 130022, People's Republic of China.
authors.forename: Hengchong
authors.initials: H
authors.lastname: Shi
authors.affiliation: State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences , Changchun 130022, People's Republic of China.
authors.forename: Shifang
authors.initials: S
authors.lastname: Luan
authors.affiliation: State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences , Changchun 130022, People's Republic of China.
authors.forename: Jinghua
authors.initials: J
authors.lastname: Yin
mesh_terms: D001777:Blood Coagulation; D020099:Coated Materials, Biocompatible; D006801:Humans; D054327:Lubricants; D013343:Styrenes / Q000737:chemistry*; D013927:Thrombosis
chemical_list: D020099:Coated Materials, Biocompatible; D054327:Lubricants; D013343:Styrenes; C500040:poly(styrene-b-isobutylene-b-styrene)
keywords: antibacterial; hemocompatibility; microfiber; slippery coating; solution blow spinning; thermoplastic elastomer