title: The association of Phosphatase and tensin homolog (PTEN) deletion and prostate cancer risk: A meta-analysis.
abstract: OBJECTIVE
  Phosphatase and tensin homolog (PTEN) deleted on chromosome 10, a tumor suppressor that negatively regulates the phosphoinositide-3-kinase(PI3K) which has been implicated in a number of human malignancies including prostate cancer. However the prognostic value of PTEN deletion in prostate cancer patient's diagnosis and the mechanism of PTEN deletion in prostate cancer development still remain unclear.
  
  
  METHODS
  A meta-analysis of 26 published studies including 8097 prostate cancer patients was performed.
  
  
  RESULTS
  Compared to PTEN normal patients, PTEN deletion patients showed a higher aggressive Gleason score(OR: 1.284, 95%CI=1.145-1.439) and pathological stage(OR: 1.628, 95%CI=1.270-2.087) which generally had a higher risk in prostate replace(HR: 1.738, 95%CI=1.264-2.390). Significant association between PTEN deletion and ERG rearrangements in prostate cancer development was also proved that compared to PTEN normal patients, patients with PTEN deletion showed a higher risk in ERG rearrangements(OR: 1.345, 95%CI=1.102-1.788).
  
  
  CONCLUSIONS
  This study indicated that patients with PTEN deletion were associated with higher pathological stage or Gleason score and a higher risk in prostate cancer replace potentially represent a novel clinically relevant event to identify individuals at increased risk for the occurrence, progression and prognosis of prostate cancer. Prostate cancer patients with PTEN deletion usually had a higher risk in ERG rearrangements than other patients may be a potential new area for identifying poor prognosis patients and selecting patients for targeted therapies which required confirmation through adequately designed prospective studies.
authors.affiliation: Department of clinical Laboratory, Nanjing First Hospital, Nanjing Medical University, 68 Changle Road, Nanjing 210006, Jiangsu, China.
authors.forename: Tianyi
authors.initials: T
authors.lastname: Gao
authors.affiliation: Department of clinical Laboratory, Nanjing First Hospital, Nanjing Medical University, 68 Changle Road, Nanjing 210006, Jiangsu, China.
authors.forename: Yanping
authors.initials: Y
authors.lastname: Mei
authors.affiliation: Central Laboratory, Nanjing First Hospital, Nanjing Medical University, 68 Changle Road, Nanjing 210006, Jiangsu, China.
authors.forename: Huiling
authors.initials: H
authors.lastname: Sun
authors.affiliation: Department of clinical Laboratory, Nanjing First Hospital, Nanjing Medical University, 68 Changle Road, Nanjing 210006, Jiangsu, China.
authors.forename: Zhenlin
authors.initials: Z
authors.lastname: Nie
authors.affiliation: Central Laboratory, Nanjing First Hospital, Nanjing Medical University, 68 Changle Road, Nanjing 210006, Jiangsu, China.
authors.forename: Xiangxiang
authors.initials: X
authors.lastname: Liu
authors.affiliation: Department of clinical Laboratory, Nanjing First Hospital, Nanjing Medical University, 68 Changle Road, Nanjing 210006, Jiangsu, China; Central Laboratory, Nanjing First Hospital, Nanjing Medical University, 68 Changle Road, Nanjing 210006, Jiangsu, China. Electronic address: shukwang@163.com.
authors.forename: Shukui
authors.initials: S
authors.lastname: Wang
mesh_terms: D017353:Gene Deletion; D015321:Gene Rearrangement / Q000235:genetics; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D051059:PTEN Phosphohydrolase / Q000235:genetics*; D011471:Prostatic Neoplasms / Q000235:genetics*; D017594:Publication Bias; D012307:Risk Factors
chemical_list: D051059:PTEN Phosphohydrolase; C494929:PTEN protein, human
keywords: ERG rearrangements; PTEN deletion; Prognostic value; Prostate cancer