title: Physically and chemically cross-linked cellulose cryogels: Structure, properties and application for controlled release.
abstract: Porous cellulose matrices were prepared via cellulose dissolution in 8wt% NaOH-water, physical gelation and chemical cross-linking with epichlorohydrin (ECH), coagulation in water and lyophilisation. Cellulose and cross-linker concentration were varied. The behaviour of gels upon coagulation and the swelling of cryogels in water were analysed. An anomalous high swelling at cross-linker concentration around stoichiometric molar ratio with cellulose was observed. Cellulose cryogel morphology, crystallinity and density were studied. The influence of chemical cross-linking on cellulose swelling was explained by suggesting that ECH acts as a spacer preventing cellulose chains tight packing during coagulation. Cellulose was loaded with a model drug, procaine hydrochloride, and the kinetics of its release was investigated.
authors.affiliation: "Petru Poni" Institute of Macromolecular Chemistry, Department of Physical Chemistry of Polymers, 41A Grigore Ghica Voda Alley, 700487 Iasi, Romania. Electronic address: dciolacu@icmpp.ro.
authors.forename: Diana
authors.initials: D
authors.lastname: Ciolacu
authors.affiliation: MINES ParisTech, PSL Research University, CEMEF-Centre de Mise en Forme des Matériaux, CNRS UMR 7635, CS 10207 rue Claude Daunesse, 06904 Sophia Antipolis, France.
authors.forename: Cyrielle
authors.initials: C
authors.lastname: Rudaz
authors.affiliation: "Babes-Bolyai" University, Faculty of Physics, Mihail Kogalniceanu, 1, 3400 Cluj-Napoca, Romania.
authors.forename: Mihai
authors.initials: M
authors.lastname: Vasilescu
authors.affiliation: MINES ParisTech, PSL Research University, CEMEF-Centre de Mise en Forme des Matériaux, CNRS UMR 7635, CS 10207 rue Claude Daunesse, 06904 Sophia Antipolis, France. Electronic address: Tatiana.Budtova@mines-paristech.fr.
authors.forename: Tatiana
authors.initials: T
authors.lastname: Budtova
mesh_terms: D000779:Anesthetics, Local / Q000737:chemistry; D002482:Cellulose / Q000737:chemistry*; D003432:Cross-Linking Reagents / Q000737:chemistry; D059985:Cryogels / Q000737:chemistry*; D003692:Delayed-Action Preparations / Q000737:chemistry; D065546:Drug Liberation; D004811:Epichlorohydrin / Q000737:chemistry; D015394:Molecular Structure; D011343:Procaine / Q000737:chemistry
chemical_list: D000779:Anesthetics, Local; D003432:Cross-Linking Reagents; D059985:Cryogels; D003692:Delayed-Action Preparations; D004811:Epichlorohydrin; D011343:Procaine; D002482:Cellulose
keywords: Cellulose; Controlled release; Cross-linking; Cryogel; Hydrogel; Swelling