title: Survival prognostic factors for patients with synchronous brain oligometastatic non-small-cell lung carcinoma receiving local therapy.
abstract: BACKGROUND
  Clinical evidence for patients with synchronous brain oligometastatic non-small-cell lung carcinoma is limited. We aimed to summarize the clinical data of these patients to explore the survival prognostic factors for this population.
  
  
  METHODS
  From September 1995 to July 2011, patients with 1-3 synchronous brain oligometastases, who were treated with stereotactic radiosurgery (SRS) or surgical resection as the primary treatment, were identified at Shanghai Chest Hospital.
  
  
  RESULTS
  A total of 76 patients (22 patients underwent brain surgery as primary treatment and 54 patients received SRS) were available for survival analysis. The overall survival (OS) for patients treated with SRS and brain surgery as the primary treatment were 12.6 months (95% confidence interval [CI] 10.3-14.9) and 16.4 months (95% CI 8.8-24.1), respectively (adjusted hazard ratio =0.59, 95% CI 0.33-1.07, P=0.08). Among 76 patients treated with SRS or brain surgery, 21 patients who underwent primary tumor resection did not experience a significantly improved OS (16.4 months, 95% CI 9.6-23.2), compared with those who did not undergo resection (11.9 months, 95% CI 9.7-14.0; adjusted hazard ratio =0.81, 95% CI 0.46-1.44, P=0.46). Factors associated with survival benefits included stage I-II of primary lung tumor and solitary brain metastasis.
  
  
  CONCLUSIONS
  There was no significant difference in OS for patients with synchronous brain oligometastasis receiving SRS or surgical resection. Among this population, the number of brain metastases and stage of primary lung disease were the factors associated with a survival benefit.
authors.affiliation: Department of Pulmonary.
authors.forename: Hao
authors.initials: H
authors.lastname: Bai
authors.affiliation: Department of Pulmonary.
authors.forename: Jianlin
authors.initials: J
authors.lastname: Xu
authors.affiliation: Department of Pathology.
authors.forename: Haitang
authors.initials: H
authors.lastname: Yang
authors.affiliation: Department of Pulmonary.
authors.forename: Bo
authors.initials: B
authors.lastname: Jin
authors.affiliation: Department of Pulmonary.
authors.forename: Yuqing
authors.initials: Y
authors.lastname: Lou
authors.affiliation: Central Laboratory, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai, People's Republic of China.
authors.forename: Dan
authors.initials: D
authors.lastname: Wu
authors.affiliation: Department of Pulmonary.
authors.forename: Baohui
authors.initials: B
authors.lastname: Han
keywords: brain; non-small-cell lung carcinoma; oligometastases; stereotactic radiosurgery; surgery