title: Upper airway structural changes induced by CPAP in OSAS patients: a study using drug-induced sleep endoscopy.
abstract: We studied upper airway structural changes induced by continuous positive airway pressure (CPAP) in obstructive sleep apnea syndrome (OSAS) patients using drug-induced sleep endoscopy (DISE). This prospective study was conducted at an academic secondary referral center. In total, 28 male OSAS patients (mean age 41.1 years) with only retropalatal level obstructions were enrolled. Measurements of the obstruction site were obtained in two steps: first a measurement was taken of the obstruction site in accordance with sleep apnea, then, a measurement was taken of the obstruction site in accordance with DISE-assisted CPAP titration, including quantitative changes in the occlusion site before and after CPAP in pixel format using an area calculation program. There was a tendency for persistent closing in cases of antero-posterior (AP) obstruction versus cases of lateral (Lat) obstruction in the CPAP titration. Lat obstructions showed a tendency to be wider than AP obstructions in the quantitative analysis. These results show that the pattern and degree of airway expansion after CPAP differ in accordance with the obstruction site.
authors.affiliation: Department Otorhinolaryngology-Head and Neck Surgery, Busan Saint Mary's Hospital, 538-41 Yongho-dong, Nam-gu, Busan, South Korea.
authors.forename: Sung Hoon
authors.initials: SH
authors.lastname: Jung
authors.affiliation: Department Otorhinolaryngology-Head and Neck Surgery, Busan Saint Mary's Hospital, 538-41 Yongho-dong, Nam-gu, Busan, South Korea. koosookweon@naver.com.
authors.forename: Soo Kweon
authors.initials: SK
authors.lastname: Koo
authors.affiliation: Department Otorhinolaryngology-Head and Neck Surgery, Busan Saint Mary's Hospital, 538-41 Yongho-dong, Nam-gu, Busan, South Korea.
authors.forename: Jang Won
authors.initials: JW
authors.lastname: Choi
authors.affiliation: Department Otorhinolaryngology-Head and Neck Surgery, Busan Saint Mary's Hospital, 538-41 Yongho-dong, Nam-gu, Busan, South Korea.
authors.forename: Ji Seung
authors.initials: JS
authors.lastname: Moon
authors.affiliation: Department Otorhinolaryngology-Head and Neck Surgery, Busan Saint Mary's Hospital, 538-41 Yongho-dong, Nam-gu, Busan, South Korea.
authors.forename: Sang Hoon
authors.initials: SH
authors.lastname: Lee
mesh_terms: D000328:Adult; D045422:Continuous Positive Airway Pressure; D004724:Endoscopy / Q000379:methods; D006801:Humans; D008297:Male; D008875:Middle Aged; D017286:Polysomnography / Q000379:methods; D011446:Prospective Studies; D020181:Sleep Apnea, Obstructive / Q000503:physiopathology* / Q000628:therapy*; D016896:Treatment Outcome
keywords: Continuous positive airway pressure; Quantitative analysis; Sleep apnea syndrome