title: CHOP Versus Chlorambucil + Prednisolone in Chronic Lymphocytic Leukemia.
abstract: One hundred and fifty-seven previously untreated stage B or C B-CLL patients were randomized to treatment with either chlorambucil + prednisolone (CLBP) 5 days every 4 weeks or CHOP every 4 weeks. Significantly more patients achieved complete remission on CHOP, but duration of response and survival were equal in the two regimens. Non-responders on CLBP were switched to CHOP, so that finally most patients received nearly the same amount and quality of treatment, which possibly explains the lack of difference in survival. However, compared to previous studies, the study-designed intensive chemotherapy seems to prolong survival for patients with advanced disease, especially those in stage C.
authors.affiliation: a Rigshospitalet, Copenhagen, Med.-Hematol. Dept. L.
authors.forename: M M
authors.initials: MM
authors.lastname: Hansen
authors.affiliation: b Viborg Hospital, Med. Dept. L.
authors.forename: E
authors.initials: E
authors.lastname: Andersen
authors.affiliation: c Gentofte Hospital, Med.-Hematol. Dept. C.
authors.forename: H
authors.initials: H
authors.lastname: Birgens
authors.affiliation: d Odense Hospital, Hematol. Dept. R.
authors.forename: B E
authors.initials: BE
authors.lastname: Christensen
authors.affiliation: e Hvidovre Hospital, Med.-Hematol. Dept. L.
authors.forename: T G
authors.initials: TG
authors.lastname: Christensen
authors.affiliation: a Rigshospitalet, Copenhagen, Med.-Hematol. Dept. L.
authors.forename: C
authors.initials: C
authors.lastname: Geisler
authors.affiliation: f Aarhus County Hospital, Med.-Hematol. Dept. B.
authors.forename: K
authors.initials: K
authors.lastname: Meldgaard
authors.affiliation: g Aarhus Municipal Hospital, the Radium Centre.
authors.forename: D
authors.initials: D
authors.lastname: Pedersen
keywords: CHOP; CLL; Chemotherapy; Chlorambucil and Prednisone