title: [Evaluation of the Effects of Remifentanil Doses on Hemodynamics and Perfusion Index at the Onset of Pneumoperitoneum during Laparoscopic Surgery].
abstract: BACKGROUND
  The aim of this study was to investigate whether changes in perfusion index (PI) correlate with non-invasive haemodynamic parameters (HR, BP) following the onset of pneumoperitoneum under two doses (moderate-dose (MD) and high-dose (HD)) of remifentanil and to compare its reliability.
  
  
  METHODS
  We divided 33 patients who were scheduled for laparoscopic surgery under general anesthesia into two groups according to the dose of continuously infused remifentanil: moderate dose 0.5 μg x kg(-1) x min(1) (MD group, n = 16) and high dose 1.0 μg x kg(-1) x min(-1) (HD group, n = 17). Non-invasive blood pressure (NIBP), HR, and PI were measured before the start of surgery (time 1), after the start of surgery (time 2), before the start of pneumoperitoneum (time 3), and 1 min after the stable state of pneumoperitoneum (time 4).
  
  
  RESULTS
  PI decreased from the baseline after pneumoperitoneum in MD group, on the other hand PI did not change in HD group. Between the two groups, the magnitude of the PI changes was statistically different although MBP and HR were not statistically different
  
  
  CONCLUSIONS
  PI may be a reliable and easier alternative to conventional haemodynamic parameters for detection of stress response to pneumoperitoneum during remifentanil anaesthesia in adult patients.
authors.forename: Makoto
authors.initials: M
authors.lastname: Sato
authors.forename: Atsushi
authors.initials: A
authors.lastname: Kurosawa
authors.forename: Tomoki
authors.initials: T
authors.lastname: Sasakawa
authors.forename: Takayuki
authors.initials: T
authors.lastname: Kunisawa
authors.forename: Osamu
authors.initials: O
authors.lastname: Takahata
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Iwasaki
mesh_terms: D000768:Anesthesia, General; D018686:Anesthetics, Intravenous; D005260:Female; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D010535:Laparoscopy; D008297:Male; D008875:Middle Aged; D010880:Piperidines / Q000008:administration & dosage*; D011027:Pneumoperitoneum / Q000601:surgery*; D000077208:Remifentanil; D015203:Reproducibility of Results
chemical_list: D018686:Anesthetics, Intravenous; D010880:Piperidines; D000077208:Remifentanil