title: Antidepressant Use After Aneurysmal Subarachnoid Hemorrhage: A Population-Based Case-Control Study.
abstract: To elucidate the predictors of antidepressant use after subarachnoid hemorrhage from saccular intracranial aneurysm (sIA-SAH) in a population-based cohort with matched controls.
  
  
  
  The Kuopio sIA database includes all unruptured and ruptured sIA cases admitted to the Kuopio University Hospital from its defined catchment population in Eastern Finland, with 3 matched controls for each patient. The use of all prescribed medicines has been fused from the Finnish national registry of prescribed medicines. In the present study, 2 or more purchases of antidepressant medication indicated antidepressant use. The risk factors of the antidepressant use were analyzed in 940 patients alive 12 months after sIA-SAH, and the classification tree analysis was used to create a predicting model for antidepressant use after sIA-SAH.
  
  
  
  The 940 12-month survivors of sIA-SAH had significantly more antidepressant use (odds ratio, 2.6; 95% confidence interval, 2.2-3.1) than their 2676 matched controls (29% versus 14%). Classification tree analysis, based on independent risk factors, was used for the best prediction model of antidepressant use after sIA-SAH. Modified Rankin Scale until 12 months was the most potent predictor, followed by condition (Hunt and Hess Scale) and age on admission for sIA-SAH.
  
  
  
  The sIA-SAH survivors use significantly more often antidepressants, indicative of depression, than their matched population controls. Even with a seemingly good recovery (modified Rankin Scale score, 0) at 12 months after sIA-SAH, there is a significant risk of depression requiring antidepressant medication.
authors.affiliation: From the Neurosurgery (J.H., A.L., M.I.K., T.H., J.F., M.F., T.K., J.E.J., A.I.) and Neurology (R.K.) of KUH NeuroCenter, and Psychiatry (H.V.), Kuopio University Hospital, and Faculty of Health Sciences, School of Medicine, Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland; and Institute of Behavioural Sciences, University of Helsinki, Finland (K.R.). jukka.huttunen@kuh.fi.
authors.forename: Jukka
authors.initials: J
authors.lastname: Huttunen
authors.affiliation: From the Neurosurgery (J.H., A.L., M.I.K., T.H., J.F., M.F., T.K., J.E.J., A.I.) and Neurology (R.K.) of KUH NeuroCenter, and Psychiatry (H.V.), Kuopio University Hospital, and Faculty of Health Sciences, School of Medicine, Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland; and Institute of Behavioural Sciences, University of Helsinki, Finland (K.R.).
authors.forename: Antti
authors.initials: A
authors.lastname: Lindgren
authors.affiliation: From the Neurosurgery (J.H., A.L., M.I.K., T.H., J.F., M.F., T.K., J.E.J., A.I.) and Neurology (R.K.) of KUH NeuroCenter, and Psychiatry (H.V.), Kuopio University Hospital, and Faculty of Health Sciences, School of Medicine, Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland; and Institute of Behavioural Sciences, University of Helsinki, Finland (K.R.).
authors.forename: Mitja I
authors.initials: MI
authors.lastname: Kurki
authors.affiliation: From the Neurosurgery (J.H., A.L., M.I.K., T.H., J.F., M.F., T.K., J.E.J., A.I.) and Neurology (R.K.) of KUH NeuroCenter, and Psychiatry (H.V.), Kuopio University Hospital, and Faculty of Health Sciences, School of Medicine, Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland; and Institute of Behavioural Sciences, University of Helsinki, Finland (K.R.).
authors.forename: Terhi
authors.initials: T
authors.lastname: Huttunen
authors.affiliation: From the Neurosurgery (J.H., A.L., M.I.K., T.H., J.F., M.F., T.K., J.E.J., A.I.) and Neurology (R.K.) of KUH NeuroCenter, and Psychiatry (H.V.), Kuopio University Hospital, and Faculty of Health Sciences, School of Medicine, Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland; and Institute of Behavioural Sciences, University of Helsinki, Finland (K.R.).
authors.forename: Juhana
authors.initials: J
authors.lastname: Frösen
authors.affiliation: From the Neurosurgery (J.H., A.L., M.I.K., T.H., J.F., M.F., T.K., J.E.J., A.I.) and Neurology (R.K.) of KUH NeuroCenter, and Psychiatry (H.V.), Kuopio University Hospital, and Faculty of Health Sciences, School of Medicine, Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland; and Institute of Behavioural Sciences, University of Helsinki, Finland (K.R.).
authors.forename: Mikael
authors.initials: M
authors.lastname: von Und Zu Fraunberg
authors.affiliation: From the Neurosurgery (J.H., A.L., M.I.K., T.H., J.F., M.F., T.K., J.E.J., A.I.) and Neurology (R.K.) of KUH NeuroCenter, and Psychiatry (H.V.), Kuopio University Hospital, and Faculty of Health Sciences, School of Medicine, Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland; and Institute of Behavioural Sciences, University of Helsinki, Finland (K.R.).
authors.forename: Timo
authors.initials: T
authors.lastname: Koivisto
authors.affiliation: From the Neurosurgery (J.H., A.L., M.I.K., T.H., J.F., M.F., T.K., J.E.J., A.I.) and Neurology (R.K.) of KUH NeuroCenter, and Psychiatry (H.V.), Kuopio University Hospital, and Faculty of Health Sciences, School of Medicine, Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland; and Institute of Behavioural Sciences, University of Helsinki, Finland (K.R.).
authors.forename: Reetta
authors.initials: R
authors.lastname: Kälviäinen
authors.affiliation: From the Neurosurgery (J.H., A.L., M.I.K., T.H., J.F., M.F., T.K., J.E.J., A.I.) and Neurology (R.K.) of KUH NeuroCenter, and Psychiatry (H.V.), Kuopio University Hospital, and Faculty of Health Sciences, School of Medicine, Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland; and Institute of Behavioural Sciences, University of Helsinki, Finland (K.R.).
authors.forename: Katri
authors.initials: K
authors.lastname: Räikkönen
authors.affiliation: From the Neurosurgery (J.H., A.L., M.I.K., T.H., J.F., M.F., T.K., J.E.J., A.I.) and Neurology (R.K.) of KUH NeuroCenter, and Psychiatry (H.V.), Kuopio University Hospital, and Faculty of Health Sciences, School of Medicine, Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland; and Institute of Behavioural Sciences, University of Helsinki, Finland (K.R.).
authors.forename: Heimo
authors.initials: H
authors.lastname: Viinamäki
authors.affiliation: From the Neurosurgery (J.H., A.L., M.I.K., T.H., J.F., M.F., T.K., J.E.J., A.I.) and Neurology (R.K.) of KUH NeuroCenter, and Psychiatry (H.V.), Kuopio University Hospital, and Faculty of Health Sciences, School of Medicine, Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland; and Institute of Behavioural Sciences, University of Helsinki, Finland (K.R.).
authors.forename: Juha E
authors.initials: JE
authors.lastname: Jääskeläinen
authors.affiliation: From the Neurosurgery (J.H., A.L., M.I.K., T.H., J.F., M.F., T.K., J.E.J., A.I.) and Neurology (R.K.) of KUH NeuroCenter, and Psychiatry (H.V.), Kuopio University Hospital, and Faculty of Health Sciences, School of Medicine, Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland; and Institute of Behavioural Sciences, University of Helsinki, Finland (K.R.).
authors.forename: Arto
authors.initials: A
authors.lastname: Immonen
mesh_terms: D000928:Antidepressive Agents / Q000627:therapeutic use*; D016022:Case-Control Studies; D003866:Depressive Disorder / Q000188:drug therapy* / Q000209:etiology; D005260:Female; D005387:Finland; D006801:Humans; D008297:Male; D008875:Middle Aged; D012042:Registries; D013345:Subarachnoid Hemorrhage / Q000150:complications*
chemical_list: D000928:Antidepressive Agents
keywords: antidepressive agents; case–control studies; depression; epilepsy; subarachnoid hemorrhage