title: Magnetic Resonance Imaging of Glucose Uptake and Metabolism in Patients with Head and Neck Cancer.
abstract: Imaging metabolic dysfunction, a hallmark of solid tumors, usually requires radioactive tracers. Chemical exchange saturation transfer (CEST) imaging can potentially detect and visualize glucose uptake and metabolism, without the need for radioisotopes. Here, we tested the feasibility of using glucose CEST (glucoCEST) to image unlabeled glucose uptake in head and neck cancer by using a clinical 3T magnetic resonance imaging (MRI) scanner. The average CEST contrast between tumors and normal tissue in 17 patients was 7.58% (P = 0.006) in the 3-4 ppm offset frequency range and 5.06% (P = 0.02) in 1-5 ppm range. In a subgroup of eight patients, glucoCEST signal enhancement was higher in tumors than in normal muscle (4.98% vs. 1.28%, P < 0.021). We conclude that glucoCEST images of head and neck cancer can be obtained with a clinical 3T MRI scanner.
authors.affiliation: Department of Radiation Physics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
authors.forename: Jihong
authors.initials: J
authors.lastname: Wang
authors.affiliation: Department of Imaging Physics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
authors.forename: Joseph
authors.initials: J
authors.lastname: Weygand
authors.affiliation: Department of Imaging Physics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
authors.forename: Ken-Pin
authors.initials: KP
authors.lastname: Hwang
authors.affiliation: Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.|Department of Clinical Oncology and Nuclear Medicine, Faculty of Medicine, Alexandria University, Alexandria, Egypt.
authors.forename: Abdallah S R
authors.initials: AS
authors.lastname: Mohamed
authors.affiliation: Department of Imaging Physics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
authors.forename: Yao
authors.initials: Y
authors.lastname: Ding
authors.affiliation: Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
authors.forename: Clifton D
authors.initials: CD
authors.lastname: Fuller
authors.affiliation: Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.|Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
authors.forename: Stephen Y
authors.initials: SY
authors.lastname: Lai
authors.affiliation: Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
authors.forename: Steven J
authors.initials: SJ
authors.lastname: Frank
authors.affiliation: Division of MR Research, Department of Radiology, Johns Hopkins University, Baltimore, MD, USA.
authors.forename: Jinyuan
authors.initials: J
authors.lastname: Zhou
mesh_terms: D001692:Biological Transport / Q000502:physiology; D002294:Carcinoma, Squamous Cell / Q000000981:diagnostic imaging / Q000473:pathology*; D005947:Glucose / Q000378:metabolism*; D006258:Head and Neck Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology*; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D008279:Magnetic Resonance Imaging / Q000379:methods*; D009960:Oropharynx / Q000000981:diagnostic imaging* / Q000473:pathology*; D049268:Positron-Emission Tomography / Q000379:methods
chemical_list: D005947:Glucose