title: CEACAM1 is overexpressed in oral tumors and related to tumorigenesis.
abstract: Carcinoembryonic antigen-related adhesion molecule 1 (CEACAM1) is a type 1 transmembrane glycoprotein belonging to the CEA family, which has been known to exist as either soluble forms in body fluids or membrane-bound forms on the cell surface. Aberrant CEACAM1 expression is associated with tumorigenesis and has been reported in a variety of human tumors, especially malignancies. The aim of this study is to determine the expression of CEACAM1 in oral tumors, trying to study CEACAM1 different expressions as a function of histotype. CEACAM1 expression was observed by immunohistochemistry (IHC) with mouse anti-human antibody for CEACAM1. IHC was performed using avidin-biotin-diaminobenzidine staining. The results were expressed as average score ± SD (0 = negative/8 = highest) for each histotype. Oral tumors expressed more CEACAM1 than normal tissues including squamous and salivary epithelia (P < 0.05). In malignancies, the squamous cell carcinoma overexpressed CEACAM1, compared to well-differentiated squamous cell with more membranous expression; the intermediately and poorly differentiated squamous cell carcinoma showed more cytoplasmic expression (P < 0.05). In addition, the salivary tumors significantly expressed more CEACAM1 than squamous cell carcinoma (P < 0.05). So, we thought oral tumors overexpressed CEACAM1 and the cytoplasmic CEACAM1 might be involved in tumorigenesis, and also CEACAM1 might be regarded as a marker of salivary glandular tumors.
authors.affiliation: Department of Geriatrics, Qilu Hospital of Shandong University, 107 Wenhua Xi Road, Jinan, 250012, Shandong, People's Republic of China.|Key Laboratory of Cardiovascular Proteomics of Shandong Province, 107 Wenhua Xi Road, Jinan, 250012, Shandong, People's Republic of China.
authors.forename: Fu-Fang
authors.initials: FF
authors.lastname: Wang
authors.affiliation: Department of Pathology, The Second Hospital, Shandong University, 247 BeiYuan Street, Jinan, 250033, Shandong, People's Republic of China.
authors.forename: Bing-Xin
authors.initials: BX
authors.lastname: Guan
authors.affiliation: Department of Pathology, The Second Hospital, Shandong University, 247 BeiYuan Street, Jinan, 250033, Shandong, People's Republic of China.
authors.forename: Jing-Yan
authors.initials: JY
authors.lastname: Yang
authors.affiliation: Department of Pathology, The Second Hospital, Shandong University, 247 BeiYuan Street, Jinan, 250033, Shandong, People's Republic of China.
authors.forename: Hai-Tao
authors.initials: HT
authors.lastname: Wang
authors.affiliation: Department of Pathology, The Second Hospital, Shandong University, 247 BeiYuan Street, Jinan, 250033, Shandong, People's Republic of China. chengjunzhou@sdu.edu.cn.
authors.forename: Cheng-Jun
authors.initials: CJ
authors.lastname: Zhou
mesh_terms: D000230:Adenocarcinoma / Q000378:metabolism / Q000473:pathology; D015703:Antigens, CD / Q000378:metabolism*; D063646:Carcinogenesis / Q000378:metabolism* / Q000473:pathology*; D002294:Carcinoma, Squamous Cell / Q000378:metabolism / Q000473:pathology; D015815:Cell Adhesion Molecules / Q000378:metabolism*; D006801:Humans; D009055:Mouth / Q000378:metabolism / Q000473:pathology; D009062:Mouth Neoplasms / Q000145:classification / Q000378:metabolism* / Q000473:pathology*
chemical_list: D015703:Antigens, CD; C069847:CD66 antigens; D015815:Cell Adhesion Molecules
keywords: CEACAM1; IHC; Oral tumors