title: Association between XPA gene rs1800975 polymorphism and susceptibility to lung cancer: a meta-analysis.
abstract: BACKGROUND
  Xeroderma pigmentosum complementation group A (XPA) gene is a key member of nucleotide excision repair pathway. It was reported that XPA rs1800975 polymorphism was associated with susceptibility to lung cancer. However, the conclusions were controversial.
  
  
  METHODS
  We conducted a computer retrieval of PubMed, EMbase, CNKI, CBM, and WanFang infrastructure platform from 1980 to 2014. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated to estimate the association strength. Publication bias was detected by means of a funnel plot.
  
  
  RESULTS
  A total of 11 articles (12 studies) involving 4257 cases and 5294 controls were included. Significant associations could be found between rs1800975 and lung cancer risk in these three models (codominant model AG vs. AA, overdominant genetic model AG vs. AA + GG, dominant model AG + GG vs. AA) in overall. In the stratified analysis by ethnicity, we found similar results as above in the Asian population. In the smoking population, the G allele carriers were associated with a significantly reduced risk of lung cancer (AG + GG vs. AA) compared with the AA carriers．Stratified analysis showed the AG genotype and G allele carriers (AG + GG) might be a protective factor compared with the AA gene for squamous carcinoma (AG vs. AA, AG + GG vs. AA).
  
  
  CONCLUSIONS
  This meta-analysis suggested that the XPA gene rs1800975 Polymorphism was associated with lung cancer susceptibility. By performing multiple separate pairwise comparisons, carriers with AG genotype under the codominant genetic model (AG vs. AA) might play actually the leading role in associating with lung cancer susceptibility in overall and in Asians.
authors.affiliation: Department of Respiratory Medicine, Fujian province geriatric Hospital, Fuzhou, 350000, People's Republic of China.
authors.forename: Xin
authors.initials: X
authors.lastname: Liu
authors.affiliation: Department of Respiratory Medicine, Affiliated Hospital of Putian University, Putian, 351100, People's Republic of China.
authors.forename: Qunying
authors.initials: Q
authors.lastname: Lin
authors.affiliation: Department of Respiratory Medicine, Zhongshan Hospital, Fudan University, Shanghai, 200032, People's Republic of China.|Respiratory Research Institute, Fudan University, Shanghai, 200032, People's Republic of China.
authors.forename: Cuiping
authors.initials: C
authors.lastname: Fu
authors.affiliation: Department of Respiratory Medicine, Affiliated Jiangyin Hospital of Southeast University, Jiangyin, 214400, People's Republic of China.
authors.forename: Chengying
authors.initials: C
authors.lastname: Liu
authors.affiliation: Department of Respiratory Medicine, Zhongshan Hospital, Fudan University, Shanghai, 200032, People's Republic of China.|Respiratory Research Institute, Fudan University, Shanghai, 200032, People's Republic of China.
authors.forename: Fen
authors.initials: F
authors.lastname: Zhu
authors.affiliation: Department of Respiratory Medicine, Zhongshan Hospital, Fudan University, Shanghai, 200032, People's Republic of China.|Respiratory Research Institute, Fudan University, Shanghai, 200032, People's Republic of China.
authors.forename: Zilong
authors.initials: Z
authors.lastname: Liu
authors.affiliation: Department of Respiratory Medicine, Zhongshan Hospital, Fudan University, Shanghai, 200032, People's Republic of China.|Respiratory Research Institute, Fudan University, Shanghai, 200032, People's Republic of China.
authors.forename: Shanqun
authors.initials: S
authors.lastname: Li
authors.affiliation: Department of Respiratory Medicine, Shanghai Chest Hospital, Shanghai Jiaotong University, Shanghai, 200032, People's Republic of China.
authors.forename: Liyan
authors.initials: L
authors.lastname: Jiang
mesh_terms: D000483:Alleles; D044466:Asian People / Q000208:ethnology / Q000235:genetics; D002294:Carcinoma, Squamous Cell / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006579:Heterozygote; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D051760:Xeroderma Pigmentosum Group A Protein / Q000235:genetics*
chemical_list: C497314:XPA protein, human; D051760:Xeroderma Pigmentosum Group A Protein
keywords: XPA; lung cancer; polymorphisms; susceptibility