title: The lncRNA MALAT1 is a novel biomarker for gastric cancer metastasis.
abstract: The metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) is frequently over-expressed and serves as a prognostic marker in human cancers. However, little is known about the role of MALAT1 in gastric cancer. Here, we reported that the tissue and plasma MALAT1 levels were significantly higher in gastric cancer patients with distant metastasis (P<0.01) than patients without distant metastasis and the healthy controls. In addition, high levels of plasma MALAT1 independently correlated to a poor prognosis for gastric cancer patients (hazard ratio, 0.242; 95% CI, 0.154-0.836; P=0.036; Cox regression analysis). Functional studies revealed that knockdown of MALAT1 could inhibit cell proliferation, cell cycle progression, migration and invasion, and promote apoptosis in gastric cancer cells. Furthermore, the miR-122-IGF-1R signaling correlated with the dysregulated MALAT1 expression in gastric cancer. These data suggest that MALAT1 could function as an oncogene in gastric cancer, and high MALAT1 level could serve as a potential biomarker for the distant metastasis of gastric cancer.
authors.affiliation: Laboratory of Signal Transduction & Molecular Targeted Therapy, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, and Collaborative Innovation Center for Biotherapy, Chengdu, Sichuan Province, China.
authors.forename: Hongwei
authors.initials: H
authors.lastname: Xia
authors.affiliation: Department of Medical Oncology, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China.|Department of Medical Oncology, Xian Yang Central Hospital, Xian Yang City, Shanxi Province, China.
authors.forename: Qingjuan
authors.initials: Q
authors.lastname: Chen
authors.affiliation: Department of Medical Oncology, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Chen
authors.affiliation: Laboratory of Signal Transduction & Molecular Targeted Therapy, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, and Collaborative Innovation Center for Biotherapy, Chengdu, Sichuan Province, China.
authors.forename: Xiaojun
authors.initials: X
authors.lastname: Ge
authors.affiliation: Department of Medical Oncology, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China.
authors.forename: Weibing
authors.initials: W
authors.lastname: Leng
authors.affiliation: Laboratory of Signal Transduction & Molecular Targeted Therapy, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, and Collaborative Innovation Center for Biotherapy, Chengdu, Sichuan Province, China.
authors.forename: Qiulin
authors.initials: Q
authors.lastname: Tang
authors.affiliation: Department of Medical Oncology, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China.
authors.forename: Ming
authors.initials: M
authors.lastname: Ren
authors.affiliation: Laboratory of Signal Transduction & Molecular Targeted Therapy, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, and Collaborative Innovation Center for Biotherapy, Chengdu, Sichuan Province, China.
authors.forename: Liang
authors.initials: L
authors.lastname: Chen
authors.affiliation: Department of Medical Oncology, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China.
authors.forename: Dandan
authors.initials: D
authors.lastname: Yuan
authors.affiliation: Laboratory of Signal Transduction & Molecular Targeted Therapy, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, and Collaborative Innovation Center for Biotherapy, Chengdu, Sichuan Province, China.
authors.forename: Yucheng
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Department of Medical Oncology, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China.
authors.forename: Ming
authors.initials: M
authors.lastname: Liu
authors.affiliation: Department of Radiology, West China Hospital of Sichuan University, Chengdu, Sichuan Province, China.
authors.forename: Qiyong
authors.initials: Q
authors.lastname: Gong
authors.affiliation: Laboratory of Signal Transduction & Molecular Targeted Therapy, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, and Collaborative Innovation Center for Biotherapy, Chengdu, Sichuan Province, China.|Department of Medical Oncology, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China.
authors.forename: Feng
authors.initials: F
authors.lastname: Bi
mesh_terms: D000230:Adenocarcinoma / Q000097:blood* / Q000401:mortality / Q000473:pathology / Q000556:secondary; D000077192:Adenocarcinoma of Lung; D017209:Apoptosis / Q000235:genetics; D014408:Biomarkers, Tumor / Q000097:blood / Q000378:metabolism*; D063646:Carcinogenesis / Q000473:pathology*; D045744:Cell Line, Tumor; D049109:Cell Proliferation; D018450:Disease Progression; D015536:Down-Regulation; D059585:G1 Phase Cell Cycle Checkpoints / Q000235:genetics; D055785:Gene Knockdown Techniques; D006801:Humans; D008175:Lung Neoplasms / Q000097:blood* / Q000401:mortality / Q000473:pathology / Q000556:secondary; D035683:MicroRNAs / Q000378:metabolism; D009367:Neoplasm Staging; D009857:Oncogenes; D011379:Prognosis; D034622:RNA Interference; D062085:RNA, Long Noncoding / Q000097:blood / Q000235:genetics / Q000378:metabolism*; D034741:RNA, Small Interfering / Q000378:metabolism; D012372:ROC Curve; D017526:Receptor, IGF Type 1; D017451:Receptors, Somatomedin / Q000378:metabolism; D012044:Regression Analysis; D015398:Signal Transduction; D013274:Stomach Neoplasms / Q000097:blood / Q000401:mortality / Q000473:pathology*; D015854:Up-Regulation
chemical_list: D014408:Biomarkers, Tumor; C000597236:IGF1R protein, human; C557041:MALAT1 long non-coding RNA, human; C531907:MIRN122 microRNA, human; D035683:MicroRNAs; D062085:RNA, Long Noncoding; D034741:RNA, Small Interfering; D017451:Receptors, Somatomedin; D017526:Receptor, IGF Type 1
keywords: MALAT1; gastric cancer; long non-coding RNA; metastasis; miR-122