title: Nickel-Promoted Recognition of Long DNA Sites by Designed Peptide Derivatives.
abstract: We describe the synthesis of designed peptidic modules that self-assemble in specific DNA sequences of 12 base pairs in the presence of Ni(II) salts. The modules consist of modified fragments of transcription factors that have been appropriately engineered to include metal-chelating His and bipyridine ligands.
authors.affiliation: Centro Singular de Investigación en Química Biolóxica e Materiais Moleculares (CIQUS), Departamento de Química Orgánica, Universidade de Santiago de Compostela, 15782, Santiago de Compostela, Spain.
authors.forename: Jéssica
authors.initials: J
authors.lastname: Rodríguez
authors.affiliation: Centro Singular de Investigación en Química Biolóxica e Materiais Moleculares (CIQUS), Departamento de Química Orgánica, Universidade de Santiago de Compostela, 15782, Santiago de Compostela, Spain.
authors.forename: Jesús
authors.initials: J
authors.lastname: Mosquera
authors.affiliation: Centro Singular de Investigación en Química Biolóxica e Materiais Moleculares (CIQUS), Departamento de Química Orgánica, Universidade de Santiago de Compostela, 15782, Santiago de Compostela, Spain. eugenio.vazquez@usc.es.
authors.forename: M Eugenio
authors.identifier: http://orcid.org/0000-0001-7500-985X
authors.initials: ME
authors.lastname: Vázquez
authors.affiliation: Centro Singular de Investigación en Química Biolóxica e Materiais Moleculares (CIQUS), Departamento de Química Orgánica, Universidade de Santiago de Compostela, 15782, Santiago de Compostela, Spain. joseluis.mascarenas@usc.es.
authors.forename: José L
authors.initials: JL
authors.lastname: Mascareñas
mesh_terms: D001483:Base Sequence; D001665:Binding Sites; D056831:Coordination Complexes / Q000737:chemistry; D004247:DNA / Q000737:chemistry*; D008024:Ligands; D009532:Nickel / Q000737:chemistry*; D009690:Nucleic Acid Conformation; D010455:Peptides / Q000737:chemistry*; D014157:Transcription Factors / Q000737:chemistry
chemical_list: D056831:Coordination Complexes; D008024:Ligands; D010455:Peptides; D014157:Transcription Factors; D009532:Nickel; D004247:DNA
keywords: DNA recognition; metallosupramolecular chemistry; minor groove binder; peptides; self-assembly