title: The Relation Between GABA and L-Arginine Levels With Some Stroke Risk Factors in Acute Ischemic Stroke Patients.
abstract: Changes in extra and intracellular neurotransmitter amino acids concentration in the early stage of acute cerebral ischemia have been reported. In this the study, serum level of gamma aminobutyric acid (GABA) and L-Arginine in acute ischemic stroke patients was assessed. 60 patients with acute ischemic stroke and sixthy healthy volunteers as a control group were assessed. Serum GABA was measured with modified enzymatic method and serum L- Arginine was measured by modified Sakaguchi method. Serum GABA level in stroke cases was lower than that of the control group. There was no relationship between GABA level and age or gender. Also, no significant correlation was observed between GABA levels with ischemic stroke risk factors such as smoking, diabetes mellitus, and hypertension. Serum L- Arginine level in patients was slightly increased in comparison with control group. There was a positive relationship between serum L- Arginine level and acute ischemic stroke risk factors. Serum GABA level was reduced in patients and had no correlation with acute ischemic stroke risk factors.
authors.affiliation: Department of Clinical Biochemistry, Babol University of Medical Sciences. Babol, Iran.; Student Research Committee, Babol University of Medical Sciences, Babol, Iran.
authors.forename: Mohsen
authors.initials: M
authors.lastname: Hosinian
authors.affiliation: Department of Clinical Biochemistry, Babol University of Medical Sciences. Babol, Iran.; Cellular and Molecular Biology Research Center (CMBRC), Health Reasearch Institute, Babol University of Medical Sciences, Babol, Iran.
authors.forename: Durdi
authors.initials: D
authors.lastname: Qujeq
authors.affiliation: Department of Neurology, Ayatollah Rouhani Hospital, Babol University of Medical Sciences, Babol, Iran.; Mobility Impairment Research Center, Babol University of Medical Sciences, Babol, Iran.
authors.forename: Alijan
authors.initials: A
authors.lastname: Ahmadi Ahangar
keywords: Gamma aminobutyric acid (GABA); acute ischemic stroke; arginine