title: Clinical Features and Peripheral Blood T Lymphocyte Subsets in Hand, Foot, and Mouth Disease According to Different Pathogens.
abstract: OBJECTIVE
  To investigate the changes in lymphocyte subsets that are caused by infection with different pathogens in children with hand, foot, and mouth disease.
  
  
  METHODS
  T lymphocyte subsets were measured in the patients' peripheral blood, and serum, throat swab, and fecal samples were tested for enterovirus.
  
  
  RESULTS
  Fecal and throat swab samples exhibited similar positive detection rates, and were significantly more likely to be positive, compared to serum samples (P < 0.01). The EV71-positive group exhibited significantly lower CD4 + TM cell counts (QR: 1.058), compared to the CD4 + TM cell counts in the CoxA16-positive group (QR: 1.391; P < 0.05).
  
  
  CONCLUSIONS
  Throat swab and fecal samples exhibited significantly higher positive detection rates, compared to serum samples. In addition, EV71-infected children exhibited significantly lower CD4+ T-cell counts, compared to CoxA16-infected children, which suggests that EV71 infection may be associated with a poorer prognosis.
authors.affiliation: Department of Infectious Diseases, Fenghua People's Hospital, Fenghua, Zhejiang Province, 315500, China. jianfangzhoucn@126.com.
authors.forename: Jian-Fang
authors.initials: JF
authors.lastname: Zhou
authors.affiliation: Department of Infectious Diseases, The Affiliated Huashan Hospital of Fudan University, Shanghai, China.
authors.forename: Zhi-Yong
authors.initials: ZY
authors.lastname: Chen
authors.affiliation: Department of Infectious Diseases, Fenghua People's Hospital, Fenghua, Zhejiang Province, 315500, China.
authors.forename: Shan-Ming
authors.initials: SM
authors.lastname: Yang
authors.affiliation: Department of Infectious Diseases, Fenghua People's Hospital, Fenghua, Zhejiang Province, 315500, China.
authors.forename: Jia-Zhen
authors.initials: JZ
authors.lastname: Chen
authors.affiliation: Department of Infectious Diseases, Fenghua People's Hospital, Fenghua, Zhejiang Province, 315500, China.
authors.forename: Ling-Ye
authors.initials: LY
authors.lastname: Zhou
authors.affiliation: Department of Infectious Diseases, Fenghua People's Hospital, Fenghua, Zhejiang Province, 315500, China.
authors.forename: Ya-Fen
authors.initials: YF
authors.lastname: Wang
authors.affiliation: Department of Infectious Diseases, Fenghua People's Hospital, Fenghua, Zhejiang Province, 315500, China.
authors.forename: Gang
authors.initials: G
authors.lastname: Wang
authors.affiliation: Department of Infectious Diseases, Fenghua People's Hospital, Fenghua, Zhejiang Province, 315500, China.
authors.forename: Xia-Jian
authors.initials: XJ
authors.lastname: Yu
authors.affiliation: Department of Infectious Diseases, The Affiliated Huashan Hospital of Fudan University, Shanghai, China.
authors.forename: Wen-Hong
authors.initials: WH
authors.lastname: Zhang
mesh_terms: D002675:Child, Preschool; D005243:Feces / Q000821:virology; D005260:Female; D006232:Hand, Foot and Mouth Disease / Q000097:blood* / Q000821:virology*; D006801:Humans; D007223:Infant; D008297:Male; D010614:Pharynx / Q000821:virology; D016133:Polymerase Chain Reaction; D011379:Prognosis; D016176:T-Lymphocyte Subsets
keywords: Clinical features; Hand-foot-and-mouth disease; T lymphocyte subsets in peripheral blood