title: Expression of the inhibitory Ly49E receptor is not critically involved in the immune response against cutaneous, pulmonary or liver tumours.
abstract: Natural killer (NK) lymphocytes are part of the innate immune system and are important in immune protection against tumourigenesis. NK cells display a broad repertoire of activating and inhibitory cell surface receptors that regulate NK cell activity. The Ly49 family of NK receptors is composed of several members that recognize major histocompatibility complex class I (MHC-I) or MHC-I-related molecules. Ly49E is a unique inhibitory member, being triggered by the non-MHC-I-related protein urokinase plasminogen activator (uPA) in contrast to the known MHC-I-triggering of the other inhibitory Ly49 receptors. Ly49E also has an uncommon expression pattern on NK cells, including high expression on liver DX5(-) NK cells. Furthermore, Ly49E is the only Ly49 member expressed by epidermal γδ T cells. As γδ T cells and/or NK cells have been shown to be involved in the regulation of cutaneous, pulmonary and liver malignancies, and as uPA is involved in tumourigenesis, we investigated the role of the inhibitory Ly49E receptor in the anti-tumour immune response. We demonstrate that, although Ly49E is highly expressed on epidermal γδ T cells and liver NK cells, this receptor does not play a major role in the control of skin tumour formation or in lung and liver tumour development.
authors.affiliation: Laboratory of Experimental Immunology, Ghent University, Ghent, Belgium.
authors.forename: Jessica
authors.initials: J
authors.lastname: Filtjens
authors.affiliation: Myeloid Cell Immunology Lab, VIB Inflammation Research Center, Ghent, Belgium.|Lab of Cellular and Molecular Immunology, Vrije Universiteit Brussel, Brussels, Belgium.
authors.forename: Jiri
authors.initials: J
authors.lastname: Keirsse
authors.affiliation: Laboratory of Experimental Immunology, Ghent University, Ghent, Belgium.
authors.forename: Els
authors.initials: E
authors.lastname: Van Ammel
authors.affiliation: Laboratory of Experimental Immunology, Ghent University, Ghent, Belgium.
authors.forename: Sylvie
authors.initials: S
authors.lastname: Taveirne
authors.affiliation: Laboratory of Experimental Immunology, Ghent University, Ghent, Belgium.
authors.forename: Aline
authors.initials: A
authors.lastname: Van Acker
authors.affiliation: Laboratory of Experimental Immunology, Ghent University, Ghent, Belgium.
authors.forename: Tessa
authors.initials: T
authors.lastname: Kerre
authors.affiliation: Laboratory of Experimental Immunology, Ghent University, Ghent, Belgium.
authors.forename: Tom
authors.initials: T
authors.lastname: Taghon
authors.affiliation: Laboratory of Experimental Immunology, Ghent University, Ghent, Belgium.
authors.forename: Bart
authors.initials: B
authors.lastname: Vandekerckhove
authors.affiliation: Laboratory of Experimental Immunology, Ghent University, Ghent, Belgium.
authors.forename: Jean
authors.initials: J
authors.lastname: Plum
authors.affiliation: Myeloid Cell Immunology Lab, VIB Inflammation Research Center, Ghent, Belgium.|Lab of Cellular and Molecular Immunology, Vrije Universiteit Brussel, Brussels, Belgium.
authors.forename: Jo A
authors.initials: JA
authors.lastname: Van Ginderachter
authors.affiliation: Laboratory of Experimental Immunology, Ghent University, Ghent, Belgium.
authors.forename: Georges
authors.initials: G
authors.lastname: Leclercq
mesh_terms: D000818:Animals; D007111:Immunity, Cellular; D007694:Killer Cells, Natural / Q000276:immunology* / Q000473:pathology; D008113:Liver Neoplasms / Q000235:genetics / Q000276:immunology* / Q000473:pathology; D008175:Lung Neoplasms / Q000235:genetics / Q000276:immunology* / Q000473:pathology; D051379:Mice; D018345:Mice, Knockout; D055650:NK Cell Lectin-Like Receptor Subfamily A / Q000235:genetics / Q000276:immunology*; D009363:Neoplasm Proteins / Q000235:genetics / Q000276:immunology*; D016692:Receptors, Antigen, T-Cell, gamma-delta / Q000235:genetics / Q000276:immunology; D012878:Skin Neoplasms / Q000235:genetics / Q000276:immunology* / Q000473:pathology; D013601:T-Lymphocytes / Q000276:immunology* / Q000473:pathology
chemical_list: C527093:Klra5 protein, mouse; D055650:NK Cell Lectin-Like Receptor Subfamily A; D009363:Neoplasm Proteins; D016692:Receptors, Antigen, T-Cell, gamma-delta