title: Chlorhexidine hexametaphosphate as a wound care material coating: antimicrobial efficacy, toxicity and effect on healing.
abstract: In this study, chlorhexidine hexametaphosphate (CHX-HMP) is investigated as a persistent antimicrobial coating for wound care materials.
  
  
  
  CHX-HMP was used as a wound care material coating and compared with chlorhexidine digluconate materials with respect to antimicrobial efficacy, toxicity and wound closure.
  
  
  
  Antimicrobial efficacy at day 1, 3 and 7 was observed with experimental and commercial materials. CHX-HMP coated materials had less toxic effect on human placental cells than commercial chlorhexidine dressings. CHX-HMP in pluronic gel did not delay healing but reduced wound colonization by E. faecalis.
  
  
  
  CHX-HMP could become a useful component of wound care materials with sustained antimicrobial efficacy, lower toxicity than chlorhexidine digluconate materials, and reduction in wound colonization without affecting closure.
authors.affiliation: Oral Nanoscience, School of Oral & Dental Sciences, University of Bristol, UK.
authors.forename: Michele E
authors.initials: ME
authors.lastname: Barbour
authors.affiliation: School of Health Sciences, Cardiff Metropolitan University, UK.
authors.forename: Sarah E
authors.initials: SE
authors.lastname: Maddocks
authors.affiliation: Oral Nanoscience, School of Oral & Dental Sciences, University of Bristol, UK.|Bristol Centre for Functional Nanomaterials, University of Bristol, UK.
authors.forename: Helena J
authors.initials: HJ
authors.lastname: Grady
authors.affiliation: School of Biochemistry, University of Bristol, UK.
authors.forename: James A
authors.initials: JA
authors.lastname: Roper
authors.affiliation: Centre for Membrane Interactions & Dynamics, Department of Biomedical Science, University of Sheffield, UK.
authors.forename: Mark D
authors.initials: MD
authors.lastname: Bass
authors.affiliation: Bristol Centre for Functional Nanomaterials, University of Bristol, UK.
authors.forename: Andrew M
authors.initials: AM
authors.lastname: Collins
authors.affiliation: School of Clinical Sciences, University of Bristol, UK.
authors.forename: Rachel M
authors.initials: RM
authors.lastname: Dommett
authors.affiliation: Bioengineering, Innovation & Research Hub (BIRCH), University Hospitals Bristol, UK.
authors.forename: Margaret
authors.initials: M
authors.lastname: Saunders
mesh_terms: D000818:Animals; D000891:Anti-Infective Agents, Local / Q000737:chemistry / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects*; D001424:Bacterial Infections / Q000517:prevention & control*; D002460:Cell Line; D002710:Chlorhexidine / Q000031:analogs & derivatives / Q000494:pharmacology*; D020099:Coated Materials, Biocompatible / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D008810:Mice, Inbred C57BL; D010710:Phosphates / Q000737:chemistry / Q000494:pharmacology; D014945:Wound Healing / Q000187:drug effects*
chemical_list: D000891:Anti-Infective Agents, Local; D020099:Coated Materials, Biocompatible; D010710:Phosphates; C005035:hexametaphosphate; D002710:Chlorhexidine
keywords: antimicrobial; catheter; chlorhexidine; healing; safety; toxicity; wound care