title: Developmental Drift and the Role of Wnt Signaling in Aging.
abstract: Population aging is a public health problem affecting the majority of the developed world. As populations age, the incidence of degenerative diseases increases exponentially, leading to large increases in public spending on healthcare. Here we summarize recent findings on the developmental drift theory of aging, and the links that have been established between aging and the Wnt signaling pathways. We focus on insights derived from model organisms connecting the evolutionary basis of aging and the link to developmental programming.
authors.affiliation: Yale-NUS College, Singapore 138527, Singapore. Gruber@yale-nus.edu.sg.|Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Singapore. Gruber@yale-nus.edu.sg.
authors.forename: Jan
authors.initials: J
authors.lastname: Gruber
authors.affiliation: Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Singapore. yee.zhuangli@u.nus.edu.
authors.forename: Zhuangli
authors.initials: Z
authors.lastname: Yee
authors.affiliation: Yale-NUS College, Singapore 138527, Singapore. Nicholas.Tolwinski@yale-nus.edu.sg.|Department of Biological Sciences, National University of Singapore, Singapore 138615, Singapore. Nicholas.Tolwinski@yale-nus.edu.sg.
authors.forename: Nicholas S
authors.initials: NS
authors.lastname: Tolwinski
keywords: aging; developmental drift; wnt