title: The effect of diabetes with pharmacotherapy for breast cancer on care resource use.
abstract: BACKGROUND
  The aim of this study was to quantify the effects of diabetes with pharmacotherapy-treated breast cancer on care resource use.
  
  
  METHODS
  The study was designed as a single institutional retrospective cohort study using hospital administrative data. The subjects were 152 patients admitted to a hospital from 2008 to 2012 diagnosed with breast cancer, and who underwent pharmacotherapy. We identified diabetes group and nondiabetes group in addition to other variables and quantified the effects of diabetes with breast cancer patients undergoing pharmacotherapy on care resource use, using a multilevel linear regression model.
  
  
  RESULTS
  Diabetes was significantly correlated to both longer length of stay (coefficient standard error: 0.75 [0.19], P < 0.001) and higher total hospital charge (0.72 [0.18], P < 0.001), controlled for age, pharmacotherapeutic agent, steroid use, admission route, procedures, and postpharmacotherapy events.
  
  
  CONCLUSIONS
  This study showed that diabetes itself is a risk factor for greater care resource use after controlling for confounding factors. Pharmacotherapy for breast cancer may influence poor glycemic control, thus leading to greater care resource use. Early detection and careful monitoring of diabetes are essential in malignancy to eliminate this burden on the health care system.
authors.affiliation: Department of Healthcare Administration and Management, Graduate School of Healthcare Sciences, Kyushu University, Fukuoka, Japan.
authors.forename: Toshiki
authors.initials: T
authors.lastname: Maeda
authors.affiliation: Department of Healthcare Administration and Management, Graduate School of Healthcare Sciences, Kyushu University, Fukuoka, Japan.
authors.forename: Akira
authors.initials: A
authors.lastname: Babazono
authors.affiliation: Department of Healthcare Administration and Management, Graduate School of Healthcare Sciences, Kyushu University, Fukuoka, Japan.
authors.forename: Takumi
authors.initials: T
authors.lastname: Nishi
authors.affiliation: Department of Healthcare Administration and Management, Graduate School of Healthcare Sciences, Kyushu University, Fukuoka, Japan.
authors.forename: Hiroki
authors.initials: H
authors.lastname: Miyazaki
authors.affiliation: Division of Internal Medicine, Okinawa Chubu Hospital 281, Miyazato, Uruma, Okinawa, Japan.
authors.forename: Kazumitsu
authors.initials: K
authors.lastname: Tamaki
authors.affiliation: Department of Management, Okinawa Chubu Hospital 281, Miyazato, Uruma, Okinawa, Japan.
authors.forename: Masashi
authors.initials: M
authors.lastname: Fujii
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use; D001943:Breast Neoplasms / Q000150:complications* / Q000188:drug therapy / Q000453:epidemiology*; D003920:Diabetes Mellitus; D005260:Female; D006295:Health Resources; D017052:Hospital Mortality; D006760:Hospitalization; D006801:Humans; D008875:Middle Aged; D010342:Patient Acceptance of Health Care