title: The Proteasome: More Than a Means to an End.
abstract: The proteasome regulates timed degradation of proteins using both intrinsic and extrinsic receptors that recognize polyubiquitin chains on targets. In this issue of Structure, Chen et al. (2016) outline the structural basis of how intrinsic receptors prefer ubiquitin-like domains rather than ubiquitin, to bind extrinsic co-receptors.
authors.affiliation: Department of Biochemistry, University of Alberta, Edmonton, AB T6G 2H7, Canada. Electronic address: leo.spyracopoulos@ualberta.ca.
authors.forename: Leo
authors.initials: L
authors.lastname: Spyracopoulos
mesh_terms: D002352:Carrier Proteins; D025821:Polyubiquitin / Q000737:chemistry*; D046988:Proteasome Endopeptidase Complex / Q000737:chemistry*; D025801:Ubiquitin / Q000737:chemistry
chemical_list: D002352:Carrier Proteins; D025801:Ubiquitin; D025821:Polyubiquitin; D046988:Proteasome Endopeptidase Complex