title: Strategies for Gene Mapping in Inherited Ophthalmic Diseases.
abstract: Gene mapping of inherited ophthalmic diseases such as congenital cataracts, retinal degeneration, glaucoma, age-related macular degeneration, myopia, optic atrophy, and eye malformations has shed more light on the disease pathology, identified targets for research on therapeutics, earlier detection, and treatment options for disease management and patient care. This article details the different approaches to gene identification for both Mendelian and complex eye disorders.
authors.affiliation: From the SNONGC Department of Genetics and Molecular Biology, Kamal Nayan Bajaj Institute for Research in Vision and Ophthalmology (KNBIRVO), Chennai, Tamil Nadu, India.
authors.forename: Sundar
authors.initials: S
authors.lastname: Srilekha
authors.forename: Bhavna
authors.initials: B
authors.lastname: Rao
authors.forename: Divya M
authors.initials: DM
authors.lastname: Rao
authors.forename: D
authors.initials: D
authors.lastname: Sudha
authors.forename: Sathya Priya
authors.initials: SP
authors.lastname: Chandrasekar
authors.forename: A J
authors.initials: AJ
authors.lastname: Pandian
authors.forename: N
authors.initials: N
authors.lastname: Soumittra
authors.forename: S
authors.initials: S
authors.lastname: Sripriya
mesh_terms: D000818:Animals; D030801:Animals, Genetically Modified; D002874:Chromosome Mapping / Q000379:methods*; D004195:Disease Models, Animal; D015785:Eye Diseases, Hereditary / Q000235:genetics*; D008040:Genetic Linkage; D006801:Humans; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D017422:Sequence Analysis, DNA / Q000379:methods