title: High Mobility Group A proteins in esophageal carcinomas.
abstract: We have recently shown that HMGA2 is overexpressed in esophageal squamous cell carcinoma (ESCC) and its detection allows to discriminate between cancer and normal surrounding tissue proposing HMGA2 as a novel diagnostic marker. Interestingly, esophageal adenocarcinoma shows an opposite behavior with the overexpression of HMGA1 but not HMGA2. Moreover, we show that the suppression of HMGA2 in 2 ESCC cell lines reduces the malignant phenotype. Then, this paper highlights a differential induction of the HMGA proteins, depending on the cancer histological type, and reinforces the perspective of an innovative esophageal cancer therapy based on the suppression of the HMGA protein function and/or expression.
authors.affiliation: a Programa de Carcinogênese Molecular, Instituto Nacional de Câncer - INCA, Rua André Cavalcanti , Rio de Janeiro , RJ , Brazil.|b Laboratório de Interações Celulares, Instituto de Ciências Biomédicas, Universidade Federal do Rio de Janeiro Prédio de Ciências da Saúde - Cidade Universitária, Ilha do Fundão, A. Carlos Chagas , Rio de Janeiro , RJ , Brasil.
authors.forename: Antonio
authors.initials: A
authors.lastname: Palumbo Júnior
authors.affiliation: a Programa de Carcinogênese Molecular, Instituto Nacional de Câncer - INCA, Rua André Cavalcanti , Rio de Janeiro , RJ , Brazil.
authors.forename: Nathalia Meireles
authors.initials: NM
authors.lastname: Da Costa
authors.affiliation: c Istituto di Endocrinologia e Oncologia Sperimentale - CNR c/o Dipartimento di Medicina Molecolare e Biotecnologie Mediche, Università degli Studi di Napoli "Federico II" - Naples , Italy.
authors.forename: Francesco
authors.initials: F
authors.lastname: Esposito
authors.affiliation: c Istituto di Endocrinologia e Oncologia Sperimentale - CNR c/o Dipartimento di Medicina Molecolare e Biotecnologie Mediche, Università degli Studi di Napoli "Federico II" - Naples , Italy.
authors.forename: Alfredo
authors.initials: A
authors.lastname: Fusco
authors.affiliation: a Programa de Carcinogênese Molecular, Instituto Nacional de Câncer - INCA, Rua André Cavalcanti , Rio de Janeiro , RJ , Brazil.
authors.forename: Luis Felipe Ribeiro
authors.initials: LF
authors.lastname: Pinto
mesh_terms: D000230:Adenocarcinoma / Q000378:metabolism / Q000473:pathology; D063646:Carcinogenesis / Q000378:metabolism / Q000473:pathology; D044127:Epigenesis, Genetic; D004938:Esophageal Neoplasms / Q000378:metabolism* / Q000473:pathology; D024003:HMGA Proteins / Q000378:metabolism*; D006801:Humans; D008954:Models, Biological
chemical_list: D024003:HMGA Proteins
keywords: HMGA based therapy; HMGA proteins; diagnostic marker; esophageal cancer; malignant phenotype