title: Prediction of bladder neck invasion and tumor extension to bladder neck margin by prostatic adenocarcinoma: a nomogram using biopsy data including transition zone tumor morphology.
abstract: Transition zone (TZ) prostatic adenocarcinoma can be identified on needle core biopsy based on tumor morphology, provided that the sample is preserved in a glutaraldehyde-based tissue fixative. TZ tumors have a propensity to grow larger than their peripheral counterparts without extraprostatic extension and finally to escape the gland by invading the bladder neck. We investigated the value of biopsy-determined parameters including TZ origin to predict the risk of isolated bladder neck invasion at radical prostatectomy. If reliable, this will enable urologists to expand their bladder neck dissection and avoid an isolated positive bladder neck margin. The study cohort consisted of 3942 patients with detailed pre operative biopsy information who underwent curative-intent radical prostatectomy between January 2010 and December 2015 in Western Australia. Multivariate logistic regression models were developed to predict isolated bladder neck invasion or isolated positive bladder neck margin. A predictive preoperative nomogram is presented. The predictive accuracy is shown in the calibration plot (the area under the curve: 0.777). The accuracy of the nomogram is dependent on the biopsy identification of transition zone cancer features, parameters only reliably interpretable after glutaraldehyde tissue fixation.
authors.affiliation: Uropath Pty Ltd, West Leederville, WA, 6007, Australia; School of Pathology and Laboratory Medicine, Faculty of Medicine and Dentistry, University of Western Australia, Crawley, WA, 6009, Australia. Electronic address: ronnie@uropath.com.au.
authors.forename: Ronald J
authors.initials: RJ
authors.lastname: Cohen
authors.affiliation: Uropath Pty Ltd, West Leederville, WA, 6007, Australia.
authors.forename: Jian
authors.initials: J
authors.lastname: Li
authors.affiliation: Hollywood Specialist Centre, Nedlands, WA, 6009, Australia.
authors.forename: Thomas
authors.initials: T
authors.lastname: Shannon
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology* / Q000601:surgery; D019540:Area Under Curve; D001706:Biopsy; D016009:Chi-Square Distribution; D016208:Databases, Factual; D003661:Decision Support Techniques; D005404:Fixatives; D005976:Glutaral; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D060787:Neoplasm Grading; D009361:Neoplasm Invasiveness; D049451:Nomograms; D016017:Odds Ratio; D011237:Predictive Value of Tests; D011468:Prostatectomy; D011471:Prostatic Neoplasms / Q000473:pathology* / Q000601:surgery; D012372:ROC Curve; D015203:Reproducibility of Results; D018570:Risk Assessment; D012307:Risk Factors; D016707:Tissue Fixation / Q000379:methods; D001743:Urinary Bladder / Q000473:pathology* / Q000601:surgery; D014904:Western Australia
chemical_list: D005404:Fixatives; D005976:Glutaral
keywords: Adenocarcinoma; Biopsy; Bladder neck invasion; Prostate; Transition zone