title: Amide bond-containing monodisperse polyethylene glycols beyond 10 000 Da.
abstract: Although monodisperse polyethylene glycols (M-PEGs) above 4000 Da are especially valuable in biomedical applications, their synthesis remains a long-standing challenge. To this end, a peptide-based strategy for such M-PEGs was developed. With macrocyclic sulfates as the key intermediates, a panel of oligoethylene glycol (OEG) containing ω-amino acids were prepared with high efficiency. Through solid phase peptide synthesis (SPPS), these amino acids were conveniently assembled into a series of amide bond-containing M-PEGs with high flexibility in molecular weight and amide density selection. With this strategy, an M-PEG of 10 262 Da was prepared on a gram scale and its biocompatibility was assessed in a mice model.
authors.affiliation: Hubei Province Engineering and Technology Research Center for Fluorinated Pharmaceuticals and School of Pharmaceutical Sciences, Wuhan University, Wuhan 430071, China. zgyang@whu.edu.cn zxjiang@whu.edu.cn.
authors.forename: Zihong
authors.initials: Z
authors.lastname: Wan
authors.affiliation: Hubei Province Engineering and Technology Research Center for Fluorinated Pharmaceuticals and School of Pharmaceutical Sciences, Wuhan University, Wuhan 430071, China. zgyang@whu.edu.cn zxjiang@whu.edu.cn.
authors.forename: Yu
authors.initials: Y
authors.lastname: Li
authors.affiliation: Hubei Province Engineering and Technology Research Center for Fluorinated Pharmaceuticals and School of Pharmaceutical Sciences, Wuhan University, Wuhan 430071, China. zgyang@whu.edu.cn zxjiang@whu.edu.cn.
authors.forename: Shaowei
authors.initials: S
authors.lastname: Bo
authors.affiliation: Hubei Province Engineering and Technology Research Center for Fluorinated Pharmaceuticals and School of Pharmaceutical Sciences, Wuhan University, Wuhan 430071, China. zgyang@whu.edu.cn zxjiang@whu.edu.cn.
authors.forename: Ming
authors.initials: M
authors.lastname: Gao
authors.affiliation: Hubei Province Engineering and Technology Research Center for Fluorinated Pharmaceuticals and School of Pharmaceutical Sciences, Wuhan University, Wuhan 430071, China. zgyang@whu.edu.cn zxjiang@whu.edu.cn.
authors.forename: Xuemeng
authors.initials: X
authors.lastname: Wang
authors.affiliation: Hubei Province Engineering and Technology Research Center for Fluorinated Pharmaceuticals and School of Pharmaceutical Sciences, Wuhan University, Wuhan 430071, China. zgyang@whu.edu.cn zxjiang@whu.edu.cn.
authors.forename: Kai
authors.initials: K
authors.lastname: Zeng
authors.affiliation: Hubei Province Engineering and Technology Research Center for Fluorinated Pharmaceuticals and School of Pharmaceutical Sciences, Wuhan University, Wuhan 430071, China. zgyang@whu.edu.cn zxjiang@whu.edu.cn.
authors.forename: Xin
authors.initials: X
authors.lastname: Tao
authors.affiliation: Hubei Province Engineering and Technology Research Center for Fluorinated Pharmaceuticals and School of Pharmaceutical Sciences, Wuhan University, Wuhan 430071, China. zgyang@whu.edu.cn zxjiang@whu.edu.cn.
authors.forename: Xuefei
authors.initials: X
authors.lastname: Li
authors.affiliation: Hubei Province Engineering and Technology Research Center for Fluorinated Pharmaceuticals and School of Pharmaceutical Sciences, Wuhan University, Wuhan 430071, China. zgyang@whu.edu.cn zxjiang@whu.edu.cn and Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, Hengyang 421001, China.
authors.forename: Zhigang
authors.initials: Z
authors.lastname: Yang
authors.affiliation: Hubei Province Engineering and Technology Research Center for Fluorinated Pharmaceuticals and School of Pharmaceutical Sciences, Wuhan University, Wuhan 430071, China. zgyang@whu.edu.cn zxjiang@whu.edu.cn and State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, Dong Hua University, Shanghai 201620, China.
authors.forename: Zhong-Xing
authors.initials: ZX
authors.lastname: Jiang
mesh_terms: D000577:Amides / Q000737:chemistry*; D000818:Animals; D001672:Biocompatible Materials / Q000138:chemical synthesis / Q000737:chemistry*; D051379:Mice; D008815:Mice, Inbred Strains; D008970:Molecular Weight; D011092:Polyethylene Glycols / Q000138:chemical synthesis / Q000737:chemistry*
chemical_list: D000577:Amides; D001672:Biocompatible Materials; D011092:Polyethylene Glycols