title: Versicones E-H and arugosin K produced by the mangrove-derived fungus Aspergillus versicolor HDN11-84.
abstract: Four new xanthonoids, versicones E-H (1-4), and a biogenetically related new derivative arugosin K (5), were isolated from a culture extract of the mangrove-derived fungus Aspergillus versicolor HDN11-84. Their structures were elucidated on the basis of extensive NMR spectroscopic data analysis. Versicone E (1) represents the first example of naturally occurring xanthonoids containing a 2-butenamide moiety. Among them, 5 showed the best cytotoxicity against Hela cell line with an IC50value of 9.2 μm.
authors.affiliation: Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao, People's Republic of China.
authors.forename: Feng
authors.initials: F
authors.lastname: Li
authors.affiliation: Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao, People's Republic of China.
authors.forename: Wenqiang
authors.initials: W
authors.lastname: Guo
authors.affiliation: Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao, People's Republic of China.
authors.forename: Qian
authors.initials: Q
authors.lastname: Che
authors.affiliation: Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao, People's Republic of China.
authors.forename: Tianjiao
authors.initials: T
authors.lastname: Zhu
authors.affiliation: Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao, People's Republic of China.
authors.forename: Qianqun
authors.initials: Q
authors.lastname: Gu
authors.affiliation: Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao, People's Republic of China.
authors.forename: Dehai
authors.initials: D
authors.lastname: Li
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D001230:Aspergillus / Q000145:classification* / Q000378:metabolism*; D001578:Benzopyrans / Q000737:chemistry / Q000378:metabolism* / Q000494:pharmacology; D001584:Benzoxepins / Q000737:chemistry / Q000378:metabolism* / Q000494:pharmacology; D045744:Cell Line, Tumor; D006801:Humans; D015394:Molecular Structure; D044004:Xanthones / Q000737:chemistry / Q000378:metabolism* / Q000494:pharmacology
chemical_list: D000970:Antineoplastic Agents; D001578:Benzopyrans; D001584:Benzoxepins; D044004:Xanthones; C000618145:arugosin K