title: The effect of glycaemic control in type 2 diabetic patients with subclinical hypothyroidism.
abstract: OBJECTIVE
  The purpose of this study was to investigate the effect of glycaemic control on subclinical hypothyroidism (SCH) in Chinese type 2 diabetic patients.
  
  
  METHODS
  The study included 476 diabetic patients with SCH admitted for treatment of type 2 diabetes. The controls were selected euthyroid patients with similar characteristics regarding [age, body mass index (BMI), gender, previous hypertension or duration of diabetes, and smoke]. Total cholesterol (TC), LDL cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), triglyceride (TG), the homeostatic model assessment of insulin resistance ratio (HOMA-IR), fasting plasma glucose, hemoglobin A1c(HbA1c), as well as plasma levels of thyrotrophin, and free thyroxine (FT4) were assessed at baseline and after 6 months of glycaemic control treatment.
  
  
  RESULTS
  The LDL-C level and HOMA-IR value were significantly higher in the SCH group. Glycaemic control reduced HOMA-IR, HbA1c, LDL-C, and TG level in patients with SCH. Furthermore, glycaemic control plays a negative effect on thyrotrophin in the SCH group, while this effect was not observed in euthyroid subjects. HbA1cplays a positive correlation with HOMA-IR (r = 0.048, p < 0.001), fasting plasma glucose (r = 0.086, p < 0.001), LDL-C (r = 0.062, p < 0.001) and TG (r = 0.021, p = 0.009).
  
  
  CONCLUSIONS
  Our study shows that glycaemic control may bring some benefits to type 2 diabetic patients with SCH.
authors.affiliation: Renmin Hospital of Wuhan University, Wuhan, China.
authors.forename: X
authors.initials: X
authors.lastname: Fu
authors.affiliation: Renmin Hospital of Wuhan University, Wuhan, China. 13437111270@163.com.
authors.forename: H
authors.initials: H
authors.lastname: Xia
authors.affiliation: The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
authors.forename: H
authors.initials: H
authors.lastname: Mao
authors.affiliation: The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
authors.forename: S
authors.initials: S
authors.lastname: Zhao
authors.affiliation: The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
authors.forename: Z
authors.initials: Z
authors.lastname: Wang
mesh_terms: D015415:Biomarkers / Q000097:blood*; D001786:Blood Glucose / Q000032:analysis*; D002851:Chromatography, High Pressure Liquid; D003924:Diabetes Mellitus, Type 2 / Q000150:complications* / Q000188:drug therapy; D005260:Female; D005455:Fluorescent Antibody Technique; D038321:Glycemic Index; D006801:Humans; D006943:Hyperglycemia / Q000188:drug therapy* / Q000209:etiology / Q000473:pathology; D007003:Hypoglycemia / Q000188:drug therapy* / Q000209:etiology / Q000473:pathology; D007004:Hypoglycemic Agents / Q000627:therapeutic use*; D007037:Hypothyroidism / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies
chemical_list: D015415:Biomarkers; D001786:Blood Glucose; D007004:Hypoglycemic Agents
keywords: Glycaemic control; Subclinical hypothyroidism; Thyrotrophin; Type 2 diabetes mellitus