title: Role of18F-FDG PET/CT differentiating olfactory neuroblastoma from sinonasal undifferentiated carcinoma.
abstract: The purpose of this study is to demonstrate the potential contribution of positron emission tomography (PET)/computed tomography (CT) to help differentiate olfactory neuroblastoma (ONB) from sinonasal undifferentiated carcinoma (SNUC).
  
  
  
  Following approval by the institutional review board at the Wexner Medical Center at the Ohio State University, Columbus, Ohio, a pilot study with retrospective review of patients with biopsy-proven diagnosis of ONB s and SNUC s was conducted. Staging PET/CT scans were reviewed to document the maximum standardized uptake value (SUVmax). A statistical comparison of SUVmax was performed.
  
  
  
  We identified 13 patients (7 with ONBs and 6 with SNUCs) with mean age 60.2 years who had undergone staging F-18 fluorodeoxyglucose (18F-FDG) PET/CT of the primary tumor at the time of their diagnosis. Mean SUVmax was found to be five-fold higher in SNUC patients (35.63, range 10.8-77.9) than in ONB patients (7.24, range 4.6-10.7) (P ≤ 0.00169).
  
  
  
  Maximum standardized uptake value of18F-FDG PET/CT can be used to initially discriminate between ONB and SNUC. This finding may prove helpful to guide diagnostic and treatment planning when the histopathologic diagnosis is inconclusive.
  
  
  
  4. Laryngoscope, 2016 127:321-324, 2017.
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, The Ohio State University Wexner Medical Center, Ohio, U.S.A.
authors.forename: Ahmad H
authors.initials: AH
authors.lastname: Elkhatib
authors.affiliation: College of Medicine, The Ohio State University, Columbus, Ohio, U.S.A.
authors.forename: Liuba
authors.initials: L
authors.lastname: Soldatova
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, The Ohio State University Wexner Medical Center, Ohio, U.S.A.|Department of Neurological Surgery, The Ohio State University Wexner Medical Center, Ohio, U.S.A.
authors.forename: Ricardo L
authors.initials: RL
authors.lastname: Carrau
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, The Ohio State University Wexner Medical Center, Ohio, U.S.A.
authors.forename: Ralph Abi
authors.initials: RA
authors.lastname: Hachem
authors.affiliation: Department of Neurosurgery, Hospital Santa Cruz, Curitiba, Brazil.
authors.forename: Leo
authors.initials: L
authors.lastname: Ditzel
authors.affiliation: Department of Otolaryngology-Head & Neck Surgery, Royal Prince Alfred Hospital, Sydney, New South Wales, Australia.
authors.forename: Raewyn
authors.initials: R
authors.lastname: Campbell
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, The Ohio State University Wexner Medical Center, Ohio, U.S.A.|Department of Neurological Surgery, The Ohio State University Wexner Medical Center, Ohio, U.S.A.
authors.forename: Daniel M
authors.initials: DM
authors.lastname: Prevedello
authors.affiliation: Department of Radiology, The Ohio State University Wexner Medical Center, Ohio, U.S.A.
authors.forename: Luciano
authors.initials: L
authors.lastname: Prevedello
authors.affiliation: Department of Neurosurgery, Hospital Santa Cruz, Curitiba, Brazil.
authors.forename: Leo F S Ditzel
authors.initials: LF
authors.lastname: Filho
authors.affiliation: Department of Otolaryngology-Head & Neck Surgery, Royal Prince Alfred Hospital, Sydney, New South Wales, Australia.
authors.forename: Raewyn G
authors.initials: RG
authors.lastname: Campbell
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001706:Biopsy; D002277:Carcinoma / Q000000981:diagnostic imaging* / Q000473:pathology; D003937:Diagnosis, Differential; D018304:Esthesioneuroblastoma, Olfactory / Q000000981:diagnostic imaging* / Q000473:pathology; D005260:Female; D019788:Fluorodeoxyglucose F18; D006801:Humans; D008297:Male; D008875:Middle Aged; D060787:Neoplasm Grading; D009367:Neoplasm Staging; D009666:Nose / Q000000981:diagnostic imaging / Q000473:pathology; D009669:Nose Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology; D010255:Paranasal Sinus Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology; D010256:Paranasal Sinuses / Q000000981:diagnostic imaging / Q000473:pathology; D010865:Pilot Projects; D000072078:Positron Emission Tomography Computed Tomography
chemical_list: D019788:Fluorodeoxyglucose F18
keywords: PET/CT; SNUC; SUVmax; olfactory neuroblastoma; sinonasal undifferentiated carcinoma