title: The Use of Solid-Phase Concentrated Growth Factors for Surgical Defects in the Treatment of Dysplastic Lesions of the Oral Mucosa.
abstract: OBJECTIVE
  Use of the skin graft and artificial dermis to reconstruct a defect after the excision of dysplastic lesions of the oral mucosa has been practiced for years. The purpose of this case series was to introduce a novel resolution-that is, an operating procedure using solid-phase concentrated growth factors (SPCGFs) to reconstruct oral mucosa defects-and observe the postoperative results and evaluate its clinical effects.
  
  
  METHODS
  In this consecutive serial case study of patients with oral dysplastic lesions who underwent operations from April 2015 through July 2015, the primary endpoint of the study was to observe the clinical wound-healing profile at 1 week, 3 weeks, 3 months, and 6 months postoperatively. The secondary endpoint was to observe maximal interincisal opening (MIO) and wound pain preoperatively and at 1 and 3 days, 1 and 3 weeks, and 3 and 6 months postoperatively. The minimum follow-up was 8 months, and the longest was 1 year.
  
  
  RESULTS
  All sites had healed with complete epithelialization after 3 weeks postoperatively. All patients had a wound-healing score no higher than 3 at 3 weeks postoperatively. The preoperative MIO was 52 ± 4.64 mm and the 6-month postoperative MIO was 49.2 ± 3.03 mm. No patient reported further pain from 3 weeks postoperatively. No recurrence of the lesion was found at or after the 6-month follow-up period.
  
  
  CONCLUSIONS
  The results of this study show that the use of SPCGFs to reconstruct oral mucosa defects is feasible and practical. The efficacy of SPCGFs needs to be verified by additional studies with higher-level evidence bases in the future.
authors.affiliation: Attending Physician, Department of Psychiatry, Kaohsiung Armed Forces General Hospital, Kaohsiung; Graduate Student, Graduate Institute of Medical Science, College of Health Science, Chang Jung Christian University, Tainan, Taiwan.
authors.forename: Shang-Lun
authors.initials: SL
authors.lastname: Lin
authors.affiliation: Associate Professor, School of Medicine, Griffith University, Gold Coast, Australia.
authors.forename: Shang-Liang
authors.initials: SL
authors.lastname: Wu
authors.affiliation: Vice Superintendent, Department of General Surgery, Madou Sin Lau Hospital, Madou; Presbyterian Church in Taiwan, Tainan; Assistant Professor, Department of Health Care Administration, Chang Jung Christian University, Tainan, Taiwan.
authors.forename: Chiang-Chin
authors.initials: CC
authors.lastname: Tsai
authors.affiliation: Associate Professor, Graduate Institute of Medical Science, College of Health Science, Chang Jung Christian University, Tainan, Taiwan.
authors.forename: Shun-Yao
authors.initials: SY
authors.lastname: Ko
authors.affiliation: Director, Department of Oral and Maxillofacial Surgery, Chi-Mei Medical Center, Liouying, Tainan, Taiwan.
authors.forename: Wei-Fan
authors.initials: WF
authors.lastname: Chiang
authors.affiliation: Director, Department of Oral and Maxillofacial Surgery, Tainan Sin Lau Hospital, Tainan; Presbyterian Church in Taiwan, Tainan; Assistant Professor, Graduate Institute of Medical Science, College of Health Science, Chang Jung Christian University, Tainan, Taiwan. Electronic address: jungwuyang1979@gmail.com.
authors.forename: Jung-Wu
authors.initials: JW
authors.lastname: Yang
mesh_terms: D000368:Aged; D002498:Centrifugation; D005500:Follow-Up Studies; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D009061:Mouth Mucosa / Q000473:pathology / Q000601:surgery*; D009062:Mouth Neoplasms / Q000473:pathology / Q000601:surgery*; D019651:Plastic Surgery Procedures / Q000379:methods*; D015607:Stents; D013536:Suture Techniques; D014945:Wound Healing
chemical_list: D036341:Intercellular Signaling Peptides and Proteins