title: Changes in the anti-HBc profile of infants born to HBV infected mothers from Iran.
abstract: From 2007 to 2014, 328 infants born to hepatitis B surface antigen (HBsAg) positive mothers, who received passive-active immunization against hepatitis B at birth were tested for HBsAg, antibody to hepatitis B core antigen (anti-HBc) and antibody to hepatitis B surface antigen (anti-HBs) at 12-15months of age. Thirteen (4%) cases were HBsAg positive. Forty-four infants who were anti-HBs, anti-HBc positive (group 1) and twenty-one infants who were anti-HBc positive alone (group 2) were identified. Both groups were followed-up annually for testing anti-HBs and anti-HBc to verify if anti-HBc was of maternal origin. In group 1, anti-HBc disappeared in 41 cases at month 24, and it disappeared from the remaining 3 cases at month 36. In group 2, anti-HBc disappeared in 18 cases at month 24 and in the remaining 3 cases at month 36. The results show that maternal anti-HBc may persist up to 3years in some children.
authors.affiliation: Infectious Diseases and Tropical Medicine Research Center, Babol University of Medical Sciences, Babol, Iran. Electronic address: hagar2q@yahoo.ca.
authors.forename: Mohammad Reza Hasanjani
authors.initials: MRH
authors.lastname: Roushan
authors.affiliation: Infectious Diseases and Tropical Medicine Research Center, Babol University of Medical Sciences, Babol, Iran.
authors.forename: Fayyaz
authors.initials: F
authors.lastname: Saedi
authors.affiliation: Razi Institute of Pathobiology, Babol, Iran.
authors.forename: Shima
authors.initials: S
authors.lastname: Soleimani
authors.affiliation: Infectious Diseases and Tropical Medicine Research Center, Babol University of Medical Sciences, Babol, Iran.
authors.forename: Masomeh
authors.initials: M
authors.lastname: Baiany
mesh_terms: D002675:Child, Preschool; D005260:Female; D006509:Hepatitis B / Q000517:prevention & control*; D006510:Hepatitis B Antibodies / Q000097:blood*; D006512:Hepatitis B Core Antigens / Q000276:immunology; D006514:Hepatitis B Surface Antigens / Q000276:immunology; D006801:Humans; D007112:Immunity, Maternally-Acquired; D007116:Immunization, Passive; D007223:Infant; D018445:Infectious Disease Transmission, Vertical / Q000517:prevention & control*; D007492:Iran; D008297:Male; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000821:virology; D014761:Viral Hepatitis Vaccines / Q000627:therapeutic use
chemical_list: D006510:Hepatitis B Antibodies; D006512:Hepatitis B Core Antigens; D006514:Hepatitis B Surface Antigens; D014761:Viral Hepatitis Vaccines
keywords: Anti-HBc; Follow-up; Infant; Maternal origin; Persistence of anti-HBc