title: No impairment of pulmonary function in children with Henoch-Schonlein purpura after 4-year follow-up.
abstract: Henoch-Schonlein purpura (HSP) is a generalized form of IgA-mediated vasculitis that usually spares pulmonary circulation. Nevertheless, it is conceivable that subclinical changes at the HSP onset may lead to lung impairment in the long term. Therefore, we decided to follow a group of HSP patients for 4 years to monitor changes in pulmonary function. A group of 11 children and adolescents diagnosed with HSP without apparent pulmonary involvement was subjected to pulmonary function tests (PFTs), i.e., spirometry, body plethysmography, and diffusing capacity for CO (DLCO); these tests were repeated after 48 months. No significant impairment was observed in variables of spirometry, body plethysmography, and DLCO expressed as % of predicted values (% predicted) after 4 years. Specifically, no significant change in DLCO, corrected for blood hemoglobin concentration was noted, i.e., 79.3 ± 10.1 vs. 81.6 ± 14.7 % predicted at the beginning and the end of the study, respectively. IgA vasculitis seems to spare pulmonary circulation as we found no impairment in PFTs within the study time frame and a median of almost 6 years from the first episode of the disease.
authors.affiliation: Department of Clinical Physiology, Medical University of Lodz, Lodz, Poland.
authors.forename: Izabela
authors.initials: I
authors.lastname: Grabska-Kobylecka
authors.affiliation: Department of Clinical Physiology, Medical University of Lodz, Lodz, Poland.
authors.forename: Dariusz
authors.initials: D
authors.lastname: Nowak
authors.affiliation: Department of Sleep Medicine and Metabolic Disorders, Medical University of Lodz, Mazowiecka 6/8, 92-215, Lodz, Poland.
authors.forename: Anna
authors.initials: A
authors.lastname: Wlodarczyk
authors.affiliation: Department of Sleep Medicine and Metabolic Disorders, Medical University of Lodz, Mazowiecka 6/8, 92-215, Lodz, Poland. piotr.bialasiewicz@umed.lodz.pl.
authors.forename: Piotr
authors.initials: P
authors.lastname: Bialasiewicz
mesh_terms: D000293:Adolescent; D002648:Child; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D011695:IgA Vasculitis / Q000175:diagnosis / Q000503:physiopathology*; D008168:Lung / Q000503:physiopathology*; D008297:Male; D011446:Prospective Studies; D012129:Respiratory Function Tests; D055815:Young Adult
keywords: Diffusing capacity for CO; Henoch-Schonlein purpura; IgA vasculitis; Pulmonary function tests