title: Long-term Survival After Surgical Treatment of Renal Cell Carcinoma Metastasis Within the Pancreas.
abstract: BACKGROUND
  The role of radical pancreatic surgery for metastatic lesions of renal cell carcinoma (RCC) remains unclear.
  
  
  METHODS
  In this analysis, 19 patients underwent pancreatic resections for metastases of RCC between 2000 and 2014.
  
  
  RESULTS
  Pancreatic metastases were diagnosed 10.2±27.1 years after primary diagnosis of RCC. Surgical approaches included pylorus preserving pancreatoduodenectomy (PPPD) (n=10, 55.6%), followed by distal pancreatectomy (n=5, 27.8%) and total pancreatectomy (n=4, 22.2%). The survival after 1, 3 and 5 years was 88.9%, 80% and 71.4%, respectively. Patients after PPPD procedure had a significant worse survival (p=0.030). RCC stage VI tumors seem to be associated with decreased short- and long-term survival rates (p=0.03). Additional metastatic lesions in the further postoperative course had no impact on outcome.
  
  
  CONCLUSIONS
  The results of our analysis demonstrate promising long-term results with regard to disease-free and overall survival after surgical therapy for pancreatic metastases of renal cell carcinoma.
authors.affiliation: Department of General, Visceral and Transplantation Surgery, Charité - Universitaetsmedizin Berlin, Berlin, Germany panagiotis.fikatas@charite.de.
authors.forename: Panagiotis
authors.initials: P
authors.lastname: Fikatas
authors.affiliation: Department of General, Visceral and Transplantation Surgery, Charité - Universitaetsmedizin Berlin, Berlin, Germany.
authors.forename: Fritz
authors.initials: F
authors.lastname: Klein
authors.affiliation: Department of General, Visceral and Transplantation Surgery, Charité - Universitaetsmedizin Berlin, Berlin, Germany.
authors.forename: Andreas
authors.initials: A
authors.lastname: Andreou
authors.affiliation: Department of General, Visceral and Transplantation Surgery, Charité - Universitaetsmedizin Berlin, Berlin, Germany.
authors.forename: Rosa Bianca
authors.initials: RB
authors.lastname: Schmuck
authors.affiliation: Department of General, Visceral and Transplantation Surgery, Charité - Universitaetsmedizin Berlin, Berlin, Germany.
authors.forename: Johann
authors.initials: J
authors.lastname: Pratschke
authors.affiliation: Department of General, Visceral and Transplantation Surgery, Charité - Universitaetsmedizin Berlin, Berlin, Germany.
authors.forename: Marcus
authors.initials: M
authors.lastname: Bahra
mesh_terms: D000328:Adult; D000368:Aged; D002292:Carcinoma, Renal Cell / Q000453:epidemiology / Q000473:pathology / Q000601:surgery*; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis; D010179:Pancreas / Q000473:pathology / Q000601:surgery*; D010180:Pancreatectomy; D010190:Pancreatic Neoplasms / Q000453:epidemiology / Q000473:pathology / Q000556:secondary / Q000601:surgery*
keywords: Renal cell carcinoma; metastasis; pancreas; survival