title: Genomic landscape of gastric cancer: molecular classification and potential targets.
abstract: Gastric cancer imposes a considerable health burden worldwide, and its mortality ranks as the second highest for all types of cancers. The limited knowledge of the molecular mechanisms underlying gastric cancer tumorigenesis hinders the development of therapeutic strategies. However, ongoing collaborative sequencing efforts facilitate molecular classification and unveil the genomic landscape of gastric cancer. Several new drivers and tumorigenic pathways in gastric cancer, including chromatin remodeling genes, RhoA-related pathways, TP53 dysregulation, activation of receptor tyrosine kinases, stem cell pathways and abnormal DNA methylation, have been revealed. These newly identified genomic alterations await translation into clinical diagnosis and targeted therapies. Considering that loss-of-function mutations are intractable, synthetic lethality could be employed when discussing feasible therapeutic strategies. Although many challenges remain to be tackled, we are optimistic regarding improvements in the prognosis and treatment of gastric cancer in the near future.
authors.affiliation: Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, 200241, China.
authors.forename: Jiawei
authors.initials: J
authors.lastname: Guo
authors.affiliation: Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, 200241, China.
authors.forename: Weiwei
authors.initials: W
authors.lastname: Yu
authors.affiliation: Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, 200241, China.
authors.forename: Hui
authors.initials: H
authors.lastname: Su
authors.affiliation: Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, 200241, China. xfpang@bio.ecnu.edu.cn.
authors.forename: Xiufeng
authors.initials: X
authors.lastname: Pang
mesh_terms: D042002:Chromatin Assembly and Disassembly; D019175:DNA Methylation; D015972:Gene Expression Regulation, Neoplastic; D023281:Genomics / Q000379:methods*; D006801:Humans; D009154:Mutation; D020794:Receptor Protein-Tyrosine Kinases / Q000235:genetics; D013234:Stem Cells / Q000166:cytology; D013274:Stomach Neoplasms / Q000235:genetics*; D016159:Tumor Suppressor Protein p53 / Q000235:genetics; D020742:rhoA GTP-Binding Protein / Q000235:genetics
chemical_list: C495901:TP53 protein, human; D016159:Tumor Suppressor Protein p53; C066737:RHOA protein, human; D020794:Receptor Protein-Tyrosine Kinases; D020742:rhoA GTP-Binding Protein
keywords: DNA methylation; RhoA; chromatin remodeling; gastric cancer; p53; receptor tyrosine kinase