title: [ERRORS IN DIAGNOSIS AND TREATMENT OF IMMUNODEPENDENT PATHOLOGY (ORIGINAL CONCEPT)].
abstract: Based on many years of experience in 2009, we developed the original concept of a mixed approach to the treatment of infectious diseases in patients. During 2.5 years(from 2013 to June 2015) to have applied for consultative-diagnostic help of 3965 patients who had not verified the primary diagnosis. The basic principle of verification of the pathology of the removal of various causes immunosuppression. Based on our extensive, research and observation was often found in patients ascaridosis (55%) and giardiasis (65%), as a possible cause of immunosuppression. In 13% of patients was found the mucosal candidiasis. Among frequently and chronically ill persons we identified the active forms of Epstein-Barr virus (quantitative polymerase chain reaction in saliva) in 40%. The criterion for assessing performance immunogram was a decrease of two sigmal deviation from the lower age limit. In the study of neutrophil myeloperoxidase content observed decline (< 60%) in 99 (9.7%) of 1015 patients, indicating a fairly common cause of long-term permit infection in the tissues and persistence C. albicans. In the study of lymphocyte subpopulations often demonstrated reduction in the number of natural killer cells (26.7% of subjects), which shows a decline of one of the most important factors of congenital immunity. Among the humoral immune disorders often noted the decrease of total IgG (2.4%) and its subclass IgG1 (22.1%), indicating a significant diagnostic value determination of IgG subclasses it even with normal serum total. Thus, approximately 76% of patients often suffer set of a decrease immunity. Patients developed with mixed infections caused by various bacterial, fungal, viral and protozoan agents and worms. Immunological study of patients should be redynamics after eliminating the causes immunosuppression and sanitation foci of infection. Only multi-level examination of the patient will determine the final diagnosis and adequate treatment.
authors.forename: V E
authors.initials: VE
authors.lastname: Kazmirchuk
authors.forename: V V
authors.initials: VV
authors.lastname: Tsaryk
authors.forename: D V
authors.initials: DV
authors.lastname: Maltsev
authors.forename: V V
authors.initials: VV
authors.lastname: Dyseeva
authors.forename: T V
authors.initials: TV
authors.lastname: Voytyuk
authors.forename: E I
authors.initials: EI
authors.lastname: Sidorenko
authors.forename: I I
authors.initials: II
authors.lastname: Solon'ko
authors.forename: A V
authors.initials: AV
authors.lastname: Pyankova
mesh_terms: D000818:Animals; D000935:Antifungal Agents / Q000627:therapeutic use; D000977:Antiparasitic Agents / Q000627:therapeutic use; D000998:Antiviral Agents / Q000627:therapeutic use; D001196:Ascariasis / Q000175:diagnosis* / Q000188:drug therapy / Q000276:immunology / Q000469:parasitology; D001200:Ascaris / Q000472:pathogenicity / Q000502:physiology; D002176:Candida albicans / Q000472:pathogenicity / Q000502:physiology; D002177:Candidiasis / Q000175:diagnosis* / Q000188:drug therapy / Q000276:immunology / Q000382:microbiology; D003951:Diagnostic Errors / Q000517:prevention & control*; D020031:Epstein-Barr Virus Infections / Q000175:diagnosis* / Q000188:drug therapy / Q000276:immunology / Q000821:virology; D005260:Female; D016829:Giardia lamblia / Q000472:pathogenicity / Q000502:physiology; D005873:Giardiasis / Q000175:diagnosis* / Q000188:drug therapy / Q000276:immunology / Q000469:parasitology; D004854:Herpesvirus 4, Human / Q000472:pathogenicity / Q000502:physiology; D006801:Humans; D016867:Immunocompromised Host; D007074:Immunoglobulin G / Q000096:biosynthesis; D007155:Immunologic Factors / Q000627:therapeutic use; D007165:Immunosuppression Therapy; D007694:Killer Cells, Natural / Q000276:immunology / Q000473:pathology; D008297:Male; D009504:Neutrophils / Q000276:immunology / Q000473:pathology; D009195:Peroxidase / Q000096:biosynthesis / Q000276:immunology
chemical_list: D000935:Antifungal Agents; D000977:Antiparasitic Agents; D000998:Antiviral Agents; D007074:Immunoglobulin G; D007155:Immunologic Factors; D009195:Peroxidase