title: Two new sesquiterpenoids produced by halophilic Nocardiopsis chromatogenes YIM 90109.
abstract: Two new germacradiene-type sesquiterpenoids, including 1(10)E,5E-germacradiene-9β,11-diol (or 9β-hydroxyl germacradienol) (1) and 11-hydroxy-1(10)E,5E-germacradien-2-one (2-oxygermacradienol) (2), together with a known geosmin-type sesquiterpenoid (1β,4β,4aβ,7α,8aα)-4,8a-dimethyloctahydronaphthalene-1,4a,7(2H)-triol (3), were elucidated by their NMR spectroscopic data, HR-ESI-MS and single-crystal X-ray diffraction from the halophilic strain Nocardiopsis chromatogenes YIM 90109. The antimicrobial activities were evaluated by paper diffusion method.
authors.affiliation: a Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences , Shandong University , Jinan , China.
authors.forename: Ming-Wei
authors.initials: MW
authors.lastname: Sun
authors.affiliation: b College of Basic Medicine , Yunnan University of Traditional Chinese Medicine , Kunming , China.
authors.forename: Xiao-Mei
authors.initials: XM
authors.lastname: Zhang
authors.affiliation: a Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences , Shandong University , Jinan , China.
authors.forename: Hui-Li
authors.initials: HL
authors.lastname: Bi
authors.affiliation: c State Key Laboratory of Biocontrol and Guangdong provincial Key Laboratory of Plant Resources, College of Ecology and Evolution , Sun Yat-Sen University , Guangzhou , China.|d Key Laboratory of Biogeography and Bioresource in Arid Land , Xinjiang Institute of Ecology and Geography, Chinese Academy of Sciences , Urumqi , China.
authors.forename: Wen-Jun
authors.initials: WJ
authors.lastname: Li
authors.affiliation: a Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences , Shandong University , Jinan , China.
authors.forename: Chun-Hua
authors.initials: CH
authors.lastname: Lu
mesh_terms: D000192:Actinomycetales / Q000737:chemistry*; D000890:Anti-Infective Agents / Q000737:chemistry* / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D005285:Fermentation; D005658:Fungi / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D012717:Sesquiterpenes / Q000737:chemistry* / Q000494:pharmacology*; D021241:Spectrometry, Mass, Electrospray Ionization; D014961:X-Ray Diffraction
chemical_list: C000618252:(10)E,5E-germacradiene-9beta,11-diol; C000618253:11-hydroxy-1(10)E,5E-germacradien-2-one; D000890:Anti-Infective Agents; D012717:Sesquiterpenes
keywords: Germacradiene-type sesquiterpenoids; Nocardiopsis chromatogenes; antimicrobial activities; crystal X-ray diffraction