title: The effect of exercise training on cutaneous microvascular reactivity: A systematic review and meta-analysis.
abstract: OBJECTIVE
  This study aimed to review the efficacy of exercise training for improving cutaneous microvascular reactivity in response to local stimulus in human adults.
  
  
  METHODS
  Systematic review with meta-analysis.
  
  
  METHODS
  A systematic search of Medline, Cinahl, AMED, Web of Science, Scopus, and Embase was conducted up to June 2015. Included studies were controlled trials assessing the effect of an exercise training intervention on cutaneous microvascular reactivity as instigated by local stimulus such as local heating, iontophoresis and post-occlusive reactive hyperaemia. Studies where the control was only measured at baseline or which included participants with vasospastic disorders were excluded. Two authors independently reviewed and selected relevant controlled trials and extracted data. Quality was assessed using the Downs and Black checklist.
  
  
  RESULTS
  Seven trials were included, with six showing a benefit of exercise training but only two reaching statistical significance with effect size ranging from -0.14 to 1.03. The meta-analysis revealed that aerobic exercise had a moderate statistically significant effect on improving cutaneous microvascular reactivity (effect size (ES)=0.43, 95% CI: 0.08-0.78, p=0.015).
  
  
  CONCLUSIONS
  Individual studies employing an exercise training intervention have tended to have small sample sizes and hence lacked sufficient power to detect clinically meaningful benefits to cutaneous microvascular reactivity. Pooled analysis revealed a clear benefit of exercise training on improving cutaneous microvascular reactivity in older and previously inactive adult cohorts. Exercise training may provide a cost-effective option for improving cutaneous microvascular reactivity in adults and may be of benefit to those with cardiovascular disease and metabolic disorders such as diabetes.
authors.affiliation: School of Health Sciences, University of Newcastle, Australia. Electronic address: sean.lanting@newcastle.edu.au.
authors.forename: Sean M
authors.initials: SM
authors.lastname: Lanting
authors.affiliation: Faculty of Health Sciences, University of Sydney, Australia; Charles Perkins Centre, University of Sydney, Australia.
authors.forename: Nathan A
authors.initials: NA
authors.lastname: Johnson
authors.affiliation: School of Exercise Science, Australian Catholic University, Australia.
authors.forename: Michael K
authors.initials: MK
authors.lastname: Baker
authors.affiliation: Charles Perkins Centre, University of Sydney, Australia.
authors.forename: Ian D
authors.initials: ID
authors.lastname: Caterson
authors.affiliation: School of Health Sciences, University of Newcastle, Australia; Priority Research Centre for Physical activity and Nutrition, University of Newcastle, Australia.
authors.forename: Vivienne H
authors.initials: VH
authors.lastname: Chuter
mesh_terms: D001810:Blood Volume; D015444:Exercise / Q000502:physiology*; D006801:Humans; D055806:Microvessels / Q000502:physiology*; D016032:Randomized Controlled Trials as Topic; D012867:Skin / Q000098:blood supply*
keywords: Exercise; Microcirculation; Physical activity; Vasodilation