title: Hypolipidemic effect of dihydroisoquinoline oxaziridine in high-fat diet-fed rats.
abstract: Obesity is a serious health problem that increases the risk of many complications, including diabetes and cardiovascular disease. This study aims to evaluate, for the first time, the effects of oxaziridine 3 on lipoprotein lipase activity in the serum of rats fed with a high-fat diet (HFD) on body weight, lipid profile and liver-kidney functions. The administration of oxaziridine 3 to HFD-rats lowered body weight and inhibited the lipase activity of obese rats leading to notable decrease of T-Ch, TGs and LDL-Ch levels accompanied with an increase in HDL-Ch concentration in serum. Moreover, the findings of this study revealed that oxaziridine 3 helped to protect liver tissue from the appearance of fatty cysts. Additionally, oxaziridine 3 administration to HFD-rats induces antioxidant activity proven by the increase of superoxide dismutase (SOD) and catalase (CAT) activities and the decrease in Thiobarbituric acid reactive substances (TBARS) levels. It also induces the protection of liver-kidney functions confirmed by a decrease in the levels of toxicity parameters in blood.
authors.affiliation: Laboratory of Chemistry of Natural Products, Faculty of Sciences, University of Sfax, B.P. 1171, 3000 Sfax, Tunisia.
authors.forename: Rihab
authors.initials: R
authors.lastname: Aydi
authors.affiliation: Laboratory of plant biotechnology applied to crop improvement, Faculty of Sciences, University of Sfax, 802, 3018 Sfax, Tunisia.
authors.forename: Amel Ben
authors.initials: AB
authors.lastname: Gara
authors.affiliation: Biochemistry Laboratory, CHU Hédi Chaker, Sfax 3000, Tunisia.
authors.forename: Rim
authors.initials: R
authors.lastname: Chaaben
authors.affiliation: Pharmacology Laboratory, Faculty of Medicine, University of Sfax, 3000 Sfax, Tunisia.
authors.forename: Hajer Ben
authors.initials: HB
authors.lastname: Saad
authors.affiliation: Laboratory of plant biotechnology applied to crop improvement, Faculty of Sciences, University of Sfax, 802, 3018 Sfax, Tunisia.
authors.forename: Lotfi
authors.initials: L
authors.lastname: Fki
authors.affiliation: Laboratory of Animal Ecophysiology, Faculty of Sciences, University of Sfax, P.O. box 802, 3018 Sfax, Tunisia.
authors.forename: Abdelfattah
authors.initials: A
authors.lastname: ElFeki
authors.affiliation: Laboratory of Biomass Valorization and Proteins Production in Eukaryotes, Center of Biotechnology of Sfax, University of Sfax, PB" 1177", 3038 Sfax, Tunisia.
authors.forename: Hafedh
authors.initials: H
authors.lastname: Belghith
authors.affiliation: Laboratory of plant biotechnology applied to crop improvement, Faculty of Sciences, University of Sfax, 802, 3018 Sfax, Tunisia.
authors.forename: Karima
authors.initials: K
authors.lastname: Belghith
authors.affiliation: Laboratory of Chemistry of Natural Products, Faculty of Sciences, University of Sfax, B.P. 1171, 3000 Sfax, Tunisia. Electronic address: majed_kammoun@yahoo.fr.
authors.forename: Majed
authors.initials: M
authors.lastname: Kammoun
mesh_terms: D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002374:Catalase / Q000378:metabolism; D059305:Diet, High-Fat; D000960:Hypolipidemic Agents / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology*; D007422:Intestines / Q000187:drug effects / Q000201:enzymology; D007546:Isoquinolines / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology*; D007668:Kidney / Q000187:drug effects / Q000473:pathology / Q000503:physiopathology; D008049:Lipase / Q000097:blood; D008055:Lipids / Q000097:blood; D008099:Liver / Q000187:drug effects / Q000473:pathology / Q000503:physiopathology; D008297:Male; D017208:Rats, Wistar; D013482:Superoxide Dismutase / Q000378:metabolism; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism
chemical_list: D000960:Hypolipidemic Agents; D007546:Isoquinolines; D008055:Lipids; D017392:Thiobarbituric Acid Reactive Substances; D002374:Catalase; D013482:Superoxide Dismutase; D008049:Lipase
keywords: Liver-kidney functions; Obesity; Oxaziridine