title: The influence of tissue microenvironment on stem cell-based cartilage repair.
abstract: Mesenchymal stem/progenitor cells and induced pluripotent stem cells have become viable cell sources for prospective cell-based cartilage engineering and tissue repair. The development and function of stem cells are influenced by the tissue microenvironment. Specifically, the local tissue microenvironment can dictate how stem cells integrate into the existing tissue matrix and how successfully they can restore function to the damaged area in question. This review focuses on the microenvironmental features of articular cartilage and how they influence stem cell-based cartilage tissue repair. Also discussed are current tissue-engineering strategies used in combination with cell-based therapies, all of which are designed to mimic the natural properties of cartilage tissue in order to achieve a better healing response.
authors.affiliation: Department of Orthopaedics, Alpert Medical School of Brown University/Rhode Island Hospital, Providence, Rhode Island.|Bone and Joint Research Center, The First Affiliated Hospital, Frontier Institute of Science and Technology, Xi'an Jiaotong University, Xi'an, China.
authors.forename: Chathuraka T
authors.initials: CT
authors.lastname: Jayasuriya
authors.affiliation: Department of Orthopaedics, Alpert Medical School of Brown University/Rhode Island Hospital, Providence, Rhode Island.|Bone and Joint Research Center, The First Affiliated Hospital, Frontier Institute of Science and Technology, Xi'an Jiaotong University, Xi'an, China.
authors.forename: Yupeng
authors.initials: Y
authors.lastname: Chen
authors.affiliation: Bone and Joint Research Center, The First Affiliated Hospital, Frontier Institute of Science and Technology, Xi'an Jiaotong University, Xi'an, China.
authors.forename: Wenguang
authors.initials: W
authors.lastname: Liu
authors.affiliation: Department of Orthopaedics, Alpert Medical School of Brown University/Rhode Island Hospital, Providence, Rhode Island.|Bone and Joint Research Center, The First Affiliated Hospital, Frontier Institute of Science and Technology, Xi'an Jiaotong University, Xi'an, China.
authors.forename: Qian
authors.initials: Q
authors.lastname: Chen
mesh_terms: D000818:Animals; D002358:Cartilage, Articular / Q000473:pathology / Q000502:physiology*; D060833:Cellular Microenvironment / Q000502:physiology*; D019902:Chondrocytes / Q000502:physiology; D006801:Humans; D057026:Induced Pluripotent Stem Cells / Q000502:physiology* / Q000637:transplantation; D059630:Mesenchymal Stem Cells / Q000502:physiology*; D023822:Tissue Engineering / Q000379:methods*
keywords: articular cartilage; cartilage repair; chondroprogenitor; microenvironment; progenitor; stem cells