title: Evaluation of Peripheral Blood Circulation Disorder in Scleroderma Patients Using an Optical Sensor with a Pressurization Mechanism.
abstract: Blood circulation function of peripheral blood vessels in skin dermis was evaluated employing an optical sensor with a pressurization mechanism using the blood outflow and reflow characteristics. The device contains a light source and an optical sensor. When applied to the skin surface, it first exerts the primary pressure (higher than the systolic blood pressure), causing an outflow of blood from the dermal peripheral blood vessels. After two heartbeats, the pressure is lowered (secondary pressure) and blood reflows into the peripheral blood vessels. Hemoglobin concentration, which changes during blood outflow and reflow, is derived from the received light intensity using the Beer-Lambert law. This method was evaluated in 26 healthy female volunteers and 26 female scleroderma patients. In order to evaluate the blood circulation function of the peripheral blood vessels of scleroderma patients, pressurization sequence which consists of primary pressure followed by secondary pressure was adopted. Blood reflow during the first heartbeat period after applying the secondary pressure of 40mmHg was (mean±SD) 0.059±0.05%mm for scleroderma patients and 0.173±0.104%mm for healthy volunteers. Blood reflow was significantly lower in scleroderma patients than in healthy volunteers (p<0.05). This result indicates that the information necessary for assessing blood circulation disorder of peripheral blood vessels in scleroderma patients is objectively obtained by the proposed method.
authors.affiliation: Graduate School of Science and Technology, Gunma University, Tenjin, Kiryu, Gunma, Japan.
authors.forename: Yoshiki
authors.initials: Y
authors.lastname: Yamakoshi
authors.affiliation: Graduate School of Medicine, Gunma University, Showa, Maebashi, Gunma, Japan.
authors.forename: Sei-Ichiro
authors.initials: S
authors.lastname: Motegi
authors.affiliation: Graduate School of Medicine, Gunma University, Showa, Maebashi, Gunma, Japan.
authors.forename: Osamu
authors.initials: O
authors.lastname: Ishikawa
mesh_terms: D000368:Aged; D001783:Blood Flow Velocity / Q000502:physiology*; D001808:Blood Vessels / Q000000981:diagnostic imaging / Q000502:physiology; D005260:Female; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D008875:Middle Aged; D011312:Pressure; D012595:Scleroderma, Systemic / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D013053:Spectrophotometry
chemical_list: D006454:Hemoglobins