title: Evaluation of efficacy and biocompatibility of a new absorbable synthetic substitute as a dural onlay graft in a large animal model.
abstract: BACKGROUND
  Numerous dura substitutes are commercially available, but no absorbable synthetic dura repair product has been used for both onlay and suture applications.
  
  
  OBJECTIVE
  The safety and effectiveness of a new absorbable synthetic substitute composed of Poly-L-lactide microfibers as onlay dural graft were evaluated.
  
  
  METHODS
  Physical properties and performance of the microfibrous synthetic dural substitute implanted as an onlay or suturable grafts were compared with these commercial products, including CODMAN ETHISORB™ Dura Patch and DuraGen™ Dural Graft Matrix, in a canine duraplasty model. The cerebrospinal fluid (CSF) leakage, macroscopic and microscopic observation at 30 and 90 days after implantation were investigated.
  
  
  RESULTS
  The absorbable synthetic dural substitute exhibited good wettability and conformability. When implanted as an onlay graft, it can prevent CSF leakage and integrate with the surrounding tissue to repair dural defects, indicating its good efficacy and biocompatibility as an onlay graft.
  
  
  CONCLUSIONS
  Based on the excellent physical properties and performances mentioned above, the new absorbable synthetic substitute can be applied as a dural graft for both onlay and suturable applications.
authors.affiliation: a Department of Mechanical Engineering , University of Texas at El Paso , El Paso , TX , USA.
authors.forename: Kunxue
authors.initials: K
authors.lastname: Deng
authors.affiliation: b Beijing Translational Engineering Center for 3D printer in Clinical Neuroscience, Department of Neurosurgery, Beijing Tiantan Hospital , Capital Medical University , Beijing , China.
authors.forename: Xun
authors.initials: X
authors.lastname: Ye
authors.affiliation: a Department of Mechanical Engineering , University of Texas at El Paso , El Paso , TX , USA.|c Multidisciplinary Research Center , Shantou University , Shantou , China.
authors.forename: Yaya
authors.initials: Y
authors.lastname: Yang
authors.affiliation: d School of Bioscience & Bioengineering , South China University of Technology , Guangzhou , China.
authors.forename: Man
authors.initials: M
authors.lastname: Liu
authors.affiliation: e Department of Neurosurgery , University Medical Centre Mainz, Johannes Gutenberg University of Mainz , Mainz , Germany.
authors.forename: Ali
authors.initials: A
authors.lastname: Ayyad
authors.affiliation: b Beijing Translational Engineering Center for 3D printer in Clinical Neuroscience, Department of Neurosurgery, Beijing Tiantan Hospital , Capital Medical University , Beijing , China.
authors.forename: Yuanli
authors.initials: Y
authors.lastname: Zhao
authors.affiliation: d School of Bioscience & Bioengineering , South China University of Technology , Guangzhou , China.
authors.forename: Yuyu
authors.initials: Y
authors.lastname: Yuan
authors.affiliation: b Beijing Translational Engineering Center for 3D printer in Clinical Neuroscience, Department of Neurosurgery, Beijing Tiantan Hospital , Capital Medical University , Beijing , China.
authors.forename: Jizong
authors.initials: J
authors.lastname: Zhao
authors.affiliation: a Department of Mechanical Engineering , University of Texas at El Paso , El Paso , TX , USA.|f Bio-manufacturing Center, Department of Mechanical Engineering , Tsinghua University , Beijing , China.
authors.forename: Tao
authors.initials: T
authors.lastname: Xu
mesh_terms: D000818:Animals; D065634:Cerebrospinal Fluid Leak / Q000601:surgery*; D004195:Disease Models, Animal; D004285:Dogs; D004388:Dura Mater / Q000601:surgery; D066298:In Vitro Techniques; D007284:Inlays / Q000379:methods*; D011091:Polyesters / Q000627:therapeutic use*; D013997:Time Factors
chemical_list: D011091:Polyesters; C033616:poly(lactide)
keywords: Absorbable synthetic dural substitute; Biomimetic; Dural repair; Onlay; Suturable