title: Bacterial magnetic nanoparticles for photothermal therapy of cancer under the guidance of MRI.
abstract: The bacterial magnetic nanoparticles (BMPs) are biomineralized by the magnetotactic bacteria and naturally covered with a layer of biomembrane. Herein, BMPs were isolated and firstly used for the photothermal therapy (PTT) of cancer under the guidance of magnetic resonance imaging (MRI) in vitro and in vivo. The results showed that BMPs could rapidly convert the energy of 808 nm near-infrared (NIR) light into heat. After internalization by the HepG2 tumor cells, BMPs with good biocompatibility could induce an efficient killing effect after NIR light irradiation, along with a change of mitochondrial membrane potential (ΔΨm) and level of intracellular reactive oxygen species (ROS). The in vivo therapy also confirms that PTT with BMPs could effectively and completely ablate the tumor in mice without inducing observable toxicity. T2-weighted MRI showed a clear tumor boundary and a 25% enhancement of negative contrast enhancement at the tumor site, suggesting that BMPs can act as an effective MRI contrast agent for guiding the PTT. Our results indicate that BMPs could be a potential theranostic agent for simultaneous MRI and PTT of cancer.
authors.affiliation: Beijing Key Laboratory of Bioelectromagnetism, Institute of Electrical Engineering, Chinese Academy of Sciences, Beijing 100190, PR China. Electronic address: chenchf@mail.iee.ac.cn.
authors.forename: Chuanfang
authors.initials: C
authors.lastname: Chen
authors.affiliation: Key Laboratory of Photochemical Conversion and Optoelectronic Materials, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100190, PR China.
authors.forename: Shunhao
authors.initials: S
authors.lastname: Wang
authors.affiliation: Beijing Institute of Nanoenergy and Nanosystems, Chinese Academy of Sciences, National Center for Nanoscience and Technology (NCNST), Beijing, 100083, PR China. Electronic address: lilinlin@binn.cas.cn.
authors.forename: Linlin
authors.initials: L
authors.lastname: Li
authors.affiliation: Beijing Key Laboratory of Bioelectromagnetism, Institute of Electrical Engineering, Chinese Academy of Sciences, Beijing 100190, PR China.
authors.forename: Pingping
authors.initials: P
authors.lastname: Wang
authors.affiliation: Beijing Key Laboratory of Bioelectromagnetism, Institute of Electrical Engineering, Chinese Academy of Sciences, Beijing 100190, PR China.
authors.forename: Changyou
authors.initials: C
authors.lastname: Chen
authors.affiliation: Beijing Key Laboratory of Bioelectromagnetism, Institute of Electrical Engineering, Chinese Academy of Sciences, Beijing 100190, PR China.
authors.forename: Zhaoyu
authors.initials: Z
authors.lastname: Sun
authors.affiliation: Beijing Key Laboratory of Bioelectromagnetism, Institute of Electrical Engineering, Chinese Academy of Sciences, Beijing 100190, PR China.
authors.forename: Tao
authors.initials: T
authors.lastname: Song
mesh_terms: D000818:Animals; D005260:Female; D056945:Hep G2 Cells; D006801:Humans; D006979:Hyperthermia, Induced / Q000379:methods; D008279:Magnetic Resonance Imaging / Q000379:methods*; D058185:Magnetite Nanoparticles / Q000737:chemistry / Q000382:microbiology / Q000627:therapeutic use*; D042201:Magnetospirillum / Q000737:chemistry / Q000378:metabolism*; D051379:Mice; D008813:Mice, Inbred ICR; D009374:Neoplasms, Experimental / Q000000981:diagnostic imaging* / Q000628:therapy*; D010789:Phototherapy / Q000379:methods*; D000068936:Theranostic Nanomedicine / Q000379:methods*; D016896:Treatment Outcome
chemical_list: D058185:Magnetite Nanoparticles
keywords: Bacterial magnetic nanoparticles; Magnetic resonance imaging; NIR light; Photothermal therapy; Tumor