title: Autologous Bone-Marrow Transplantation in Acute Lymphoblastic Leukaemia: 1980-89.
abstract: The outcome of conventional therapy in adult acute lymphoblastic leukaemia (ALL) is disappointing. Allogeneic bone-marrow transplantation may give improved results but has only limited applicability because of the lack of a suitable donor in most patients. We have therefore investigated intensive chemotherapy and chemo/radiotherapy protocols with autologous bone-marrow rescue. 31 patients have been treated, 14 beyond first remission and 17 in first remission. The result of this therapy in both groups is poor with only 2 longterm survivors in each group. There is no reason to believe from this study that ablative therapy with autologous bone-marrow rescue will yield superior results to conventional therapy in adult ALL but further experience with TBI containing regimes is required.
authors.affiliation: a University College Hospital, London, UK.
authors.forename: A K
authors.initials: AK
authors.lastname: Mcmillan
authors.affiliation: a University College Hospital, London, UK.
authors.forename: J G
authors.initials: JG
authors.lastname: Gribben
authors.affiliation: a University College Hospital, London, UK.
authors.forename: D C
authors.initials: DC
authors.lastname: Linch
authors.affiliation: b Whipps Cross Hospital, London, UK.
authors.forename: C
authors.initials: C
authors.lastname: Anderson
authors.affiliation: a University College Hospital, London, UK.
authors.forename: J D
authors.initials: JD
authors.lastname: Richards
authors.affiliation: a University College Hospital, London, UK.
authors.forename: A H
authors.initials: AH
authors.lastname: Goldstone
keywords: Autologous bone-marrow transplantation; acute lymphoblastic leukaemia