title: Bupropion improved apathy in behavioral variant frontotemporal dementia: a case report.
abstract: Apathy is a common neurobehavioral sign in cases of behavioral variant frontotemporal dementia. However, there is still no established sustained effective treatment. We present the case of a 65-year-old man with behavioral variant frontotemporal dementia who suffered from severe apathy, but his apathy improved after a 10-month period of bupropion treatment. His single photon emission computed tomography report also showed slight improvement. To the best of our knowledge, such a case with imaging evidence has never been reported. Further studies to correlate the effects of bupropion on apathy in behavioral variant frontotemporal dementia patients are clearly needed.
authors.affiliation: a Department of Psychiatry , Taipei Medical University-Shuang Ho Hospital , New Taipei City , R.O.C.
authors.forename: Chia-Pei
authors.initials: CP
authors.lastname: Lin
authors.affiliation: b Department of Psychosomatic Medicine , Taipei City Psychiatric Center , Taipei City Hospital , Taipei City, R.O.C.
authors.forename: Chih-Pang
authors.initials: CP
authors.lastname: Chu
authors.affiliation: c Department of General Psychiatry , Taipei City Psychiatric Center , Taipei City Hospital , Taipei City, R.O.C.|d Department of Psychiatry, School of Medicine , Taipei Medical University , Taipei City , R.O.C.
authors.forename: Hsing-Cheng
authors.initials: HC
authors.lastname: Liu
mesh_terms: D000368:Aged; D018687:Antidepressive Agents, Second-Generation / Q000627:therapeutic use*; D057565:Apathy / Q000187:drug effects*; D001921:Brain / Q000000981:diagnostic imaging / Q000187:drug effects; D016642:Bupropion / Q000627:therapeutic use*; D057180:Frontotemporal Dementia / Q000150:complications* / Q000000981:diagnostic imaging / Q000523:psychology; D006801:Humans; D001523:Mental Disorders / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000209:etiology*; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D018687:Antidepressive Agents, Second-Generation; D016642:Bupropion
keywords: Apathy; bupropion; dopamine; motivation; single photon emission computed tomography