title: Cationic Ionic Liquids Organic Ligands Based Metal-Organic Frameworks for Fabrication of Core-Shell Microspheres for Hydrophilic Interaction Liquid Chromatography.
abstract: In this study, new metal-organic frameworks (MOFs) nanocrystals modified SiO2 core-shell microspheres were designed with cationic ionic liquids (ILs) 1,3-bis(4-carboxybutyl)imidazolium bromide (ILI) as organic ligands. By further adjustment the growth cycles, the new ILI-01@SiO2 core-shell stationary phase was facilely fabricated. The developed stationary phase was respectively characterized via element analysis, thermogravimetric analysis, scanning electron microscopy, X-ray diffraction, and Fourier transform infrared spectrometry. Because the introduction of cationic imidazolium-based ILs ILI for fabrication of the MOFs nanocrystals shell, the new stationary phase exhibits the retention mechanism of hydrophilic interaction liquid chromatography (HILIC). Many polar samples, such as amides, vitamins, nucleic acid bases, and nucleosides, were utilized to investigate the performance of the prepared ILI-01@SiO2 column. Compared to the conventional aminosilica column, the new ILI-01@SiO2 column displays high separation selectivity in a shorter separation time. Furthermore, the new ILI-01@SiO2 column was also used for detection of illegal melamine addition in the baby formula. All the above results demonstrate the new ILI-01@SiO2 core-shell stationary phase is of good potentials for high-selectivity separation the polar samples.
authors.affiliation: College of Pharmacy, Key Laboratory of Medicinal Chemistry & Molecular Diagnosis, Ministry of Education, Hebei University , Baoding 071002, China.
authors.forename: Qian
authors.initials: Q
authors.lastname: Dai
authors.affiliation: College of Pharmacy, Key Laboratory of Medicinal Chemistry & Molecular Diagnosis, Ministry of Education, Hebei University , Baoding 071002, China.
authors.forename: Junqian
authors.initials: J
authors.lastname: Ma
authors.affiliation: College of Pharmacy, Key Laboratory of Medicinal Chemistry & Molecular Diagnosis, Ministry of Education, Hebei University , Baoding 071002, China.
authors.forename: Siqi
authors.initials: S
authors.lastname: Ma
authors.affiliation: College of Pharmacy, Key Laboratory of Medicinal Chemistry & Molecular Diagnosis, Ministry of Education, Hebei University , Baoding 071002, China.
authors.forename: Shengyu
authors.initials: S
authors.lastname: Wang
authors.affiliation: College of Chemistry and Environmental Science, Hebei University , Baoding 071002, China.
authors.forename: Lijun
authors.initials: L
authors.lastname: Li
authors.affiliation: College of Pharmacy, Key Laboratory of Medicinal Chemistry & Molecular Diagnosis, Ministry of Education, Hebei University , Baoding 071002, China.
authors.forename: Xianghui
authors.initials: X
authors.lastname: Zhu
authors.affiliation: College of Pharmacy, Key Laboratory of Medicinal Chemistry & Molecular Diagnosis, Ministry of Education, Hebei University , Baoding 071002, China.
authors.forename: Xiaoqiang
authors.initials: X
authors.lastname: Qiao
keywords: HILIC; MOFs nanocrystals; core−shell stationary phase; high-efficiency separation; ionic liquids