title: Liver dysfunction and anti-thyroid therapy.
abstract: Thioamides have been used in the management of hyperthyroidism for over 50 years. Liver dysfunction is a rare but important side effect associated with their use. Recently, cases of liver failure associated with propylthiouracil have prompted the Federal Drug Administration to issue a Boxed Warning to the label of propylthiouracil regarding its risk of potentially fatal liver injury and acute liver failure in adults and children. Herein, we present a case to underline the importance of recognising the similar potential for severe hepatic dysfunction with the use of other thioamides.
authors.affiliation: Department of Endocrinology and Diabetes, St Vincent's Hospital-Melbourne, Melbourne, VIC, Australia.
authors.forename: Danae A
authors.initials: DA
authors.lastname: Papachristos
authors.affiliation: Department of Endocrinology and Diabetes, St Vincent's Hospital-Melbourne, Melbourne, VIC, Australia.
authors.forename: Jenny
authors.initials: J
authors.lastname: Huynh
authors.affiliation: Endocrine Centre of Excellence, Austin Health, Melbourne, VIC, Australia; Department of Medicine, University of Melbourne, Melbourne, VIC, Australia.
authors.forename: Mathis
authors.initials: M
authors.lastname: Grossman
authors.affiliation: Department of Endocrinology and Diabetes, St Vincent's Hospital-Melbourne, Melbourne, VIC, Australia; Department of Medicine, University of Melbourne, Melbourne, VIC, Australia.
authors.forename: Richard J
authors.initials: RJ
authors.lastname: MacIsaac
keywords: Diabetes/endocrinology; carbimazole; hyperthyroidism; liver dysfunction; pharmacoepidemiology/drug safety