title: [Infections and epigenetic changes in cancer].
abstract: The role of epigenetics and infectious diseases at early stages of life influence pre-malignant lesions of cancer, in particular, gastric cancer, one of the most frequent tumours in Chile, Latin America, and worldwide. This article examines the role of H.pylori and epigenetic alterations (i.e. DNA methylation) at early stages of gastric cancer and proposes, from the paediatric point of view, strategies for prevention and early detection.
authors.affiliation: Departamento de Hematología y Oncología, División de Medicina, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile. Electronic address: corvalan@med.puc.cl.
authors.forename: Alejandro H
authors.initials: AH
authors.lastname: Corvalán
authors.affiliation: Departamento de Hematología y Oncología, División de Medicina, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile.
authors.forename: María José
authors.initials: MJ
authors.lastname: Maturana
mesh_terms: D002648:Child; D002677:Chile; D019175:DNA Methylation; D055088:Early Detection of Cancer / Q000379:methods; D044127:Epigenesis, Genetic; D016481:Helicobacter Infections / Q000150:complications* / Q000453:epidemiology / Q000382:microbiology; D016480:Helicobacter pylori / Q000302:isolation & purification; D006801:Humans; D013274:Stomach Neoplasms / Q000235:genetics / Q000382:microbiology / Q000517:prevention & control*
keywords: Cáncer gástrico; DNA methylation; Gastric cancer; Helicobacter pylori; Metilación del ADN