title: Click-Dimerized Cinchona Alkaloids.
abstract: A series of Cinchona alkaloid-derived dimers were obtained in high yields in copper-catalyzed 1,3-dipolar "click" cycloaddition using bis(TMS)butadiyne and other bivalent alkynes. The products with bitriazole linkers were effective ligands for asymmetric copper-catalyzed Michael addition. It was shown that the presence of such linker was responsible for effective chirality transfer.
authors.affiliation: Department of Organic Chemistry, Wrocław University of Technology , Wyspiańskiego 27, Wrocław 50-370, Poland.
authors.forename: Przemysław J
authors.initials: PJ
authors.lastname: Boratyński
authors.affiliation: Department of Organic Chemistry, Wrocław University of Technology , Wyspiańskiego 27, Wrocław 50-370, Poland.
authors.forename: Rafał
authors.initials: R
authors.lastname: Kowalczyk
mesh_terms: D000480:Alkynes / Q000737:chemistry; D066241:Carbon-13 Magnetic Resonance Spectroscopy; D002930:Cinchona Alkaloids / Q000737:chemistry*; D057930:Click Chemistry; D003300:Copper / Q000737:chemistry; D061565:Cycloaddition Reaction; D019281:Dimerization; D066244:Proton Magnetic Resonance Spectroscopy; D021241:Spectrometry, Mass, Electrospray Ionization
chemical_list: D000480:Alkynes; D002930:Cinchona Alkaloids; D003300:Copper