title: Quality of life in patients with nonalcoholic fatty liver disease in combination with essential hypertension considering taste sensitivity to sodium chloride.
abstract: BACKGROUND
  Nonalcoholic fatty liver disease and hypertensive disease - is the most common combination of abnormalities that occur in people suffering from metabolic syndrome. Their combination not only causes concurrent damage of the liver and the heart, caused by common pathogenic beginning, and also mutually complicate the disease course of each other. The leading role in the development of nonalcoholic fatty liver disease belongs to abdominal obesity and insulin resistance, and is seen as a manifestation of liver disease in metabolic syndrome. Genetic predisposition, lifestyle, improper nutrition, including excessive use of sodium chloride, lead to excessive formation of visceral adipose tissue with development of abdominal obesity, which is a likely criterion of insulin resistance. The long course of nonalcoholic fatty liver disease in combination with essential hypertension in excessive consumption of sodium chloride may negatively affect their quality of life. The aim of the study is to find out the features of quality of life in patients with nonalcoholic fatty liver disease in combination with hypertensive disease with different taste sensitivity to sodium chloride.
  
  
  METHODS
  We have investigated the quality of life of 65 patients with nonalcoholic fatty liver disease in combination with hypertensive disease II stage with different taste sensitivity to sodium chloride. Salt taste sensitivity threshold to sodium chloride is determined by the method of R. Henkin. Assessment of quality of life was performed using the Ukrainian version of the questionnaire Medical Outcomes Study Short Form 36 (MO S SF-36).
  
  
  RESULTS
  Was revealed that in patients with nonalcoholic fatty liver disease in combination with hypertensive disease II stage with high salt taste sensitivity threshold observed the decline in the quality of life that manifests as a decline in physical condition (especially of the physical functioning, physical role functioning and general health perceptions) and mental health (especially social functioning). Also the increased salt intake and salt appetite in patients with high salt taste sensitivity threshold were noted (p <0,05).
  
  
  CONCLUSIONS
  Reducing the use of sodium chloride can be a preventive measure easier than a decrease in body weight, and one that will reduce the body weight, especially in people with nonalcoholic fatty liver disease in combination with hypertensive disease, can reduce the risk of complications and improve quality of life in patients.
authors.affiliation: Department of Faculty Therapy, Medical Faculty, Uzhhorod National University, Gryboyedova street, 10, 88000 Uzhhorod, Ukraine Tel.: (0312)64-36-52 e-mail: anna.fatula@gmail.com.
authors.forename: Hanna Y
authors.initials: HY
authors.lastname: Mashura
authors.affiliation: Department of Faculty Therapy, Medical Faculty, Uzhhorod National University, Uzhhorod, Ukraine.
authors.forename: Taras M
authors.initials: TM
authors.lastname: Hanych
authors.affiliation: Department of Faculty Therapy, Medical Faculty, Uzhhorod National University, Uzhhorod, Ukraine.
authors.forename: Alexander A
authors.initials: AA
authors.lastname: Rishko
mesh_terms: D000075222:Essential Hypertension / Q000150:complications*; D006304:Health Status; D006801:Humans; D065626:Non-alcoholic Fatty Liver Disease / Q000150:complications*; D011788:Quality of Life; D012965:Sodium Chloride; D013649:Taste
chemical_list: D012965:Sodium Chloride
keywords: hypertensive disease; nonalcoholic fatty liver disease; quality of life; salt taste sensitivity threshold; sodium chloride