title: Colitis, independent of macronutrient intake, compromises bone structure and strength in growing piglets.
abstract: Deterioration in bone health is a concern in managing pediatric inflammatory bowel diseases, but clear understanding of the independent contributions of disease and nutrition is lacking. This study aimed to ascertain whether bone health could be conserved during colitis by maintaining adequate nutritional intake in growing piglets.
  
  
  
  The effect of colitis on bone structure and strength was determined in piglets with dextran sulphate sodium-induced colitis. Piglets received either 100% macro/micronutrient requirements or 50% macro/100% micronutrient requirements. Femurs were analyzed for dual-energy x-ray absorptiometry, peripheral quantitative computed tomography, microcomputed tomography, and 3-point bending tests.
  
  
  
  Colitis, regardless of a well-nourished or malnourished diet, compromised areal bone mineral density (-17%) and volumetric bone mineral density (-20%) in cortical and trabecular bone. Structural integrity at mid-diaphysis was maintained during colitis; however, lower cortical area, trabecular area, and bone mineral content resulted in lower energy to break.
  
  
  
  Colitis compromises both bone structure and strength of long bones in piglets, independent of macronutrient intakes. Although confirmation of these findings in pediatric cohorts is needed, these data identify aspects of bone health that may be affected by inflammatory bowel disease.
authors.affiliation: School of Dietetics and Human Nutrition, McGill University, Montreal, Quebec, Canada.
authors.forename: Photios
authors.initials: P
authors.lastname: Vassilyadi
authors.affiliation: School of Dietetics and Human Nutrition, McGill University, Montreal, Quebec, Canada.|Diabetes and Nutritional Sciences Division, Faculty of Life Sciences and Medicine, King's College, London, UK.
authors.forename: Scott V
authors.initials: SV
authors.lastname: Harding
authors.affiliation: School of Dietetics and Human Nutrition, McGill University, Montreal, Quebec, Canada.|Department of Kinesiology and Physical Education, Wilfrid Laurier University, Waterloo, Ontario, Canada.
authors.forename: Tom J
authors.initials: TJ
authors.lastname: Hazell
authors.affiliation: School of Dietetics and Human Nutrition, McGill University, Montreal, Quebec, Canada.
authors.forename: Hope A
authors.initials: HA
authors.lastname: Weiler
authors.affiliation: School of Dietetics and Human Nutrition, McGill University, Montreal, Quebec, Canada.
authors.forename: Linda J
authors.initials: LJ
authors.lastname: Wykes
mesh_terms: D015502:Absorptiometry, Photon; D000818:Animals; D001696:Biomechanical Phenomena; D015519:Bone Density; D003092:Colitis / Q000150:complications / Q000503:physiopathology*; D016264:Dextran Sulfate / Q000737:chemistry; D004032:Diet; D005269:Femur / Q000002:abnormalities* / Q000000981:diagnostic imaging* / Q000473:pathology; D007249:Inflammation; D018977:Micronutrients; D009752:Nutritional Status; D013552:Swine; D055114:X-Ray Microtomography
chemical_list: D018977:Micronutrients; D016264:Dextran Sulfate