title: [Stimulation of spermatogenesis: For whom? Why? How?].
abstract: The stimulation of spermatogenesis is the best treatment of infertility for male hypogonadotropic-hypogonadism. The results are very pleasing because a real improvement of semen is sometimes obtained with spontaneous pregnants describing in the literature but after a long duration of treatment, often many months. Sometimes, the treatment improves the technical conditions of ICSI for the embryologists. Stimulation of spermatogenesis by gonadotrophins rFSH and/or hCG is the most used but others treatments, like pulsatile GnRH therapy or clomifene citrate can be used. The purpose of this review is to described the different protocols of stimulation of spermatogenesis and explain their results and finally to see if others indications of stimulation of spermatogenesis are existing.
authors.affiliation: Service de gynécologie endocrinienne et médecine de la reproduction, hôpital Jeanne-de-Flandre, CHRU de Lille, avenue Eugène-Avinée, 59037 Lille cedex, France; Service d'andrologie, hôpital Albert-Calmette, CHRU de Lille, boulevard du Professeur-Jules-Leclercq, 59000 Lille cedex, France.
authors.forename: J
authors.initials: J
authors.lastname: Bertrand-Delepine
authors.affiliation: Service d'andrologie, hôpital Albert-Calmette, CHRU de Lille, boulevard du Professeur-Jules-Leclercq, 59000 Lille cedex, France; Service d'endocrinologie, hôpital Claude-Huriez, CHRU de Lille, rue Michel-Polonovski, 59037 Lille cedex, France.
authors.forename: C
authors.initials: C
authors.lastname: Leroy
authors.affiliation: Service d'andrologie, hôpital Albert-Calmette, CHRU de Lille, boulevard du Professeur-Jules-Leclercq, 59000 Lille cedex, France; EA 4308 « Gamétogenèse et qualité du gamète », CHU de Rouen, 1, rue de Germont, 76031 Rouen cedex, France.
authors.forename: J-M
authors.initials: JM
authors.lastname: Rigot
authors.affiliation: Service de gynécologie endocrinienne et médecine de la reproduction, hôpital Jeanne-de-Flandre, CHRU de Lille, avenue Eugène-Avinée, 59037 Lille cedex, France.
authors.forename: S
authors.initials: S
authors.lastname: Catteau-Jonard
authors.affiliation: Service de gynécologie endocrinienne et médecine de la reproduction, hôpital Jeanne-de-Flandre, CHRU de Lille, avenue Eugène-Avinée, 59037 Lille cedex, France.
authors.forename: D
authors.initials: D
authors.lastname: Dewailly
authors.affiliation: Service de gynécologie endocrinienne et médecine de la reproduction, hôpital Jeanne-de-Flandre, CHRU de Lille, avenue Eugène-Avinée, 59037 Lille cedex, France; Service d'andrologie, hôpital Albert-Calmette, CHRU de Lille, boulevard du Professeur-Jules-Leclercq, 59000 Lille cedex, France; EA 4308 « Gamétogenèse et qualité du gamète », CHU de Rouen, 1, rue de Germont, 76031 Rouen cedex, France. Electronic address: geoffroy.ROBIN@chru-lille.fr.
authors.forename: G
authors.initials: G
authors.lastname: Robin
mesh_terms: D006063:Chorionic Gonadotropin / Q000627:therapeutic use; D002996:Clomiphene / Q000627:therapeutic use; D005640:Follicle Stimulating Hormone / Q000627:therapeutic use; D007987:Gonadotropin-Releasing Hormone / Q000008:administration & dosage; D006801:Humans; D007006:Hypogonadism / Q000188:drug therapy* / Q000209:etiology; D007030:Hypothalamo-Hypophyseal System / Q000503:physiopathology; D007248:Infertility, Male / Q000188:drug therapy* / Q000209:etiology; D008297:Male; D013091:Spermatogenesis / Q000187:drug effects / Q000502:physiology; D013737:Testis / Q000503:physiopathology
chemical_list: D006063:Chorionic Gonadotropin; D002996:Clomiphene; D007987:Gonadotropin-Releasing Hormone; D005640:Follicle Stimulating Hormone
keywords: Citrate de clomifène; Clomifene citrate; Gonadotrophines; Gonadotropins; Hypogonadisme hypogonadotrope; Hypogonadotropic-hypogonadism; Infertilité masculine; Male infertility; Pompe à GnRH; Pulsatile GnRH therapy; Stimulation de la spermatogenèse; Stimulation of spermatogenesis