title: Galactose-decorated light-responsive hydrogelator precursors for selectively killing cancer cells.
abstract: A multi-functional gelator precursor with high photosensitivity is rationally designed, which can not only selectively target hepatocellular carcinoma (HCC) cells, but also form intracellular self-assembly triggered by light and subsequently inducing cell death. The study develops a methodology to design biological targets of supramolecular self-assembly under external stimuli for cancer research.
authors.affiliation: State Key Lab of Metal Matrix Composites, School of Materials Science and Engineering, Shanghai Jiao Tong University, 800 Dongchuan Road, 200240, Shanghai, China. clfeng@sjtu.edu.cn.
authors.forename: Wei
authors.initials: W
authors.lastname: Ji
authors.affiliation: State Key Lab of Metal Matrix Composites, School of Materials Science and Engineering, Shanghai Jiao Tong University, 800 Dongchuan Road, 200240, Shanghai, China. clfeng@sjtu.edu.cn.
authors.forename: Guofeng
authors.initials: G
authors.lastname: Liu
authors.affiliation: State Key Lab of Metal Matrix Composites, School of Materials Science and Engineering, Shanghai Jiao Tong University, 800 Dongchuan Road, 200240, Shanghai, China. clfeng@sjtu.edu.cn.
authors.forename: Fang
authors.initials: F
authors.lastname: Wang
authors.affiliation: Department of Nephrology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University, 227 South Chongqing Road, 200011, Shanghai, China.
authors.forename: Zhu
authors.initials: Z
authors.lastname: Zhu
authors.affiliation: State Key Lab of Metal Matrix Composites, School of Materials Science and Engineering, Shanghai Jiao Tong University, 800 Dongchuan Road, 200240, Shanghai, China. clfeng@sjtu.edu.cn.
authors.forename: Chuanliang
authors.initials: C
authors.lastname: Feng
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology*; D006528:Carcinoma, Hepatocellular / Q000188:drug therapy / Q000473:pathology*; D016923:Cell Death; D005690:Galactose / Q000737:chemistry*; D006801:Humans; D020100:Hydrogels / Q000737:chemistry*; D008027:Light; D008113:Liver Neoplasms / Q000188:drug therapy / Q000473:pathology*; D014407:Tumor Cells, Cultured
chemical_list: D000970:Antineoplastic Agents; D020100:Hydrogels; D005690:Galactose