title: Rapidly progressive neurological deterioration in anti-AMPA receptor encephalitis with additional CRMP5 antibodies.
abstract: Anti-α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR) encephalitis positive for additional onconeural antibodies is rarely reported. Here we report the clinical features of a patient who developed limbic encephalitis with both glutamate receptor 2 (GluR2) and collapsin response mediator protein 5 (CRMP5) antibodies. Brain magnetic resonance imaging revealed multifocal encephalopathy. Chest computed tomography showed a highly suspicious malignant thymoma. He experienced rapid neurological deterioration during hospitalization. This report indicates that the clinical diversity of anti-AMPAR encephalitis and the presence of onconeural antibodies may lead to poor prognosis.
authors.affiliation: Department of Neurology, The First Affiliated Hospital of Zhengzhou University, No.1 Jianshe E Rd, Erqi District, Zhengzhou, 450052, Henan, China.
authors.forename: Shuangshuang
authors.initials: S
authors.lastname: Yang
authors.affiliation: Department of Neurology, The First Affiliated Hospital of Zhengzhou University, No.1 Jianshe E Rd, Erqi District, Zhengzhou, 450052, Henan, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Qin
authors.affiliation: Department of Neurology, The First Affiliated Hospital of Zhengzhou University, No.1 Jianshe E Rd, Erqi District, Zhengzhou, 450052, Henan, China.
authors.forename: Jinghong
authors.initials: J
authors.lastname: Li
authors.affiliation: Department of Neurology, The First Affiliated Hospital of Zhengzhou University, No.1 Jianshe E Rd, Erqi District, Zhengzhou, 450052, Henan, China.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Gao
authors.affiliation: Department of Neurology, The First Affiliated Hospital of Zhengzhou University, No.1 Jianshe E Rd, Erqi District, Zhengzhou, 450052, Henan, China.
authors.forename: Lu
authors.initials: L
authors.lastname: Zhao
authors.affiliation: Department of Neurology, The First Affiliated Hospital of Zhengzhou University, No.1 Jianshe E Rd, Erqi District, Zhengzhou, 450052, Henan, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Wu
authors.affiliation: Department of Neurology, The First Affiliated Hospital of Zhengzhou University, No.1 Jianshe E Rd, Erqi District, Zhengzhou, 450052, Henan, China.
authors.forename: Bo
authors.initials: B
authors.lastname: Song
authors.affiliation: Department of Neurology, The First Affiliated Hospital of Zhengzhou University, No.1 Jianshe E Rd, Erqi District, Zhengzhou, 450052, Henan, China.
authors.forename: Yuming
authors.initials: Y
authors.lastname: Xu
authors.affiliation: Department of Neurology, The First Affiliated Hospital of Zhengzhou University, No.1 Jianshe E Rd, Erqi District, Zhengzhou, 450052, Henan, China. sunshilei18@163.com.
authors.forename: Shilei
authors.initials: S
authors.lastname: Sun
mesh_terms: D000328:Adult; D020274:Autoimmune Diseases of the Nervous System / Q000276:immunology / Q000473:pathology / Q000503:physiopathology; D004660:Encephalitis / Q000276:immunology / Q000473:pathology / Q000503:physiopathology; D006801:Humans; D006867:Hydrolases; D008297:Male; D008869:Microtubule-Associated Proteins; D009419:Nerve Tissue Proteins / Q000276:immunology*; D017470:Receptors, Glutamate / Q000276:immunology*; D013945:Thymoma / Q000000981:diagnostic imaging*; D013953:Thymus Neoplasms / Q000000981:diagnostic imaging*
chemical_list: D008869:Microtubule-Associated Proteins; D009419:Nerve Tissue Proteins; D017470:Receptors, Glutamate; C492973:alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid subtype glutamate receptor, human; C415087:DPYSL5 protein, human; D006867:Hydrolases
keywords: AMPAR; Antibodies; Autoimmune; CRMP5; Encephalitis; Thymoma