title: Body weight changes after adjuvant chemotherapy of patients with breast cancer: results of a Mexican cohort study.
abstract: Weight gain is observed in breast cancer patients receiving chemotherapy and is a well-known complication. Several factors that contributing to weight gain have been identified. However, there is a lack of information about factors associated with weight changes following adjuvant chemotherapy. A retrospective cohort of 200 pre- and post-menopausal Mexican patients treated for breast cancer was made. Anthropometric variables were measured before/after treatment. Biomarkers, cellular differentiation and chemotherapy were similar between groups. Weight gain occurred in 85.6% of pre-menopausal and 72.6% of post-menopausal women (p = .03). At the end of chemotherapy, weight and body mass index (BMI) did not differ significantly between pre-menopausal (69.3 ± 12.6 kg; 26.6 ± 4.8 kg/m2) and post-menopausal women (69.5 ± 10.9 kg; 27.3 ± 4.4 kg/m2) (p = .91 and 0.34). Dexamethasone doses were higher in pre-menopausal (85.7 ± 39.1 g) than post-menopausal patients (79.2 ± 22.5 g; p = .13). Weight loss was observed in 9.2% of pre-menopausal and 20.2% of post-menopausal patients (p = .04). A multivariate analysis revealed that age (OR = 2.7; 95% CI = 1.26-5.79; p = .01), menopausal status (OR = 2.29; 95% CI = 1.09-4.80; p = .03), dexamethasone dosage (OR = 2.1; 95% CI = 1.04-4.23; p = .03) and daily caloric intake (OR = 2.3; 95% CI = 1.12-5.10; p = .02) were independent variables that inducted weight gain. Pre- and post-menopausal women gained weight, but more pre-menopausal patients showed gain. An effort should be made to administer lower steroid doses to reduce weight gain.
authors.affiliation: Private Oncology Unit, ONKOS, Guadalajara, Mexico.
authors.forename: A
authors.initials: A
authors.lastname: Vargas-Meza
authors.affiliation: Research Unit in Clinical Epidemiology, Specialties Hospital of the Western National Medical Center, Mexican Institute of Social Security, Guadalajara, Mexico.
authors.forename: M
authors.initials: M
authors.lastname: Chavez-Tostado
authors.affiliation: Private Oncology Unit, ONKOS, Guadalajara, Mexico.
authors.forename: A O
authors.initials: AO
authors.lastname: Cortes-Flores
authors.affiliation: Private Oncology Unit, ONKOS, Guadalajara, Mexico.
authors.forename: D
authors.initials: D
authors.lastname: Urias-Valdez
authors.affiliation: Private Oncology Unit, ONKOS, Guadalajara, Mexico.
authors.forename: M
authors.initials: M
authors.lastname: Delgado-Gomez
authors.affiliation: Private Oncology Unit, ONKOS, Guadalajara, Mexico.
authors.forename: G
authors.initials: G
authors.lastname: Morgan-Villela
authors.affiliation: Private Oncology Unit, ONKOS, Guadalajara, Mexico.
authors.forename: C
authors.initials: C
authors.lastname: Zuloaga-Fernandez Del Valle
authors.affiliation: Private Oncology Unit, ONKOS, Guadalajara, Mexico.
authors.forename: J
authors.initials: J
authors.lastname: Jimenez-Tornero
authors.affiliation: Private Oncology Unit, ONKOS, Guadalajara, Mexico.
authors.forename: R
authors.initials: R
authors.lastname: Zuloaga-Fernandez Del Valle
authors.affiliation: Research Unit in Clinical Epidemiology, Specialties Hospital of the Western National Medical Center, Mexican Institute of Social Security, Guadalajara, Mexico.
authors.forename: C
authors.initials: C
authors.lastname: Fuentes-Orozco
authors.affiliation: Research Unit in Clinical Epidemiology, Specialties Hospital of the Western National Medical Center, Mexican Institute of Social Security, Guadalajara, Mexico.
authors.forename: J
authors.initials: J
authors.lastname: García-Rentería
authors.affiliation: Research Unit in Clinical Epidemiology, Specialties Hospital of the Western National Medical Center, Mexican Institute of Social Security, Guadalajara, Mexico.
authors.forename: J
authors.initials: J
authors.lastname: Rendón-Félix
authors.affiliation: Research Unit in Clinical Epidemiology, Specialties Hospital of the Western National Medical Center, Mexican Institute of Social Security, Guadalajara, Mexico.
authors.forename: L
authors.initials: L
authors.lastname: Cuesta-Márquez
authors.affiliation: Research Unit in Clinical Epidemiology, Specialties Hospital of the Western National Medical Center, Mexican Institute of Social Security, Guadalajara, Mexico.
authors.forename: A
authors.initials: A
authors.lastname: Gonzalez-Ojeda
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D018931:Antineoplastic Agents, Hormonal / Q000008:administration & dosage; D015992:Body Mass Index; D001835:Body Weight; D001943:Breast Neoplasms / Q000188:drug therapy*; D017024:Chemotherapy, Adjuvant; D015331:Cohort Studies; D003907:Dexamethasone / Q000008:administration & dosage; D004305:Dose-Response Relationship, Drug; D002149:Energy Intake; D005260:Female; D006801:Humans; D008800:Mexico; D008875:Middle Aged; D015999:Multivariate Analysis; D016017:Odds Ratio; D017698:Postmenopause; D017697:Premenopause; D012189:Retrospective Studies; D015430:Weight Gain; D015431:Weight Loss
chemical_list: D000970:Antineoplastic Agents; D018931:Antineoplastic Agents, Hormonal; D003907:Dexamethasone
keywords: adjuvant; breast cancer; chemotherapy; post-menopausal; pre-menopausal; weight gain