title: Ultrastructural pathology of human liver in Rift Valley fever.
abstract: Rift Valley fever (RVF) is a zoonotic disease that primarily affects ruminant animals and can also cause fatal disease in humans. In the current report, we present the ultrastructural changes in the liver of a man aged 60 years who died from RVF in the Aseer Central Hospital, Abha, Saudi Arabia. The main hepatic changes by transmission electron microscopy included the presence of 95-115 nm electron-dense particles consistent with RVF virions, nuclear condensation, vacuolar degeneration, lipid droplet accumulation and mitochondrial damage and dilation. There were also viral inclusion bodies with electron-dense aggregates, dilation of intercellular spaces, damage of sinusoidal microvilli with widening of space of Disse, dilation of bile canaliculi and increasing number of phagolysosomes.
authors.affiliation: Department of Pathology, College of Medicine, King Khalid University, Abbha, Saudi Arabia.
authors.forename: Mubarak Al
authors.initials: MA
authors.lastname: Shraim
authors.affiliation: Department of Pathology, College of Medicine, King Khalid University, Abbha, Saudi Arabia.
authors.forename: Refaat
authors.initials: R
authors.lastname: Eid
authors.affiliation: Department of Pathology, College of Medicine, King Khalid University, Abbha, Saudi Arabia.
authors.forename: Khaled
authors.initials: K
authors.lastname: Radad
authors.affiliation: Department of Pathology, Jawaharlal Nehru Medical College and Hospital, Aligarh, Uttar Pradesh, India.
authors.forename: Noora
authors.initials: N
authors.lastname: Saeed
mesh_terms: D001648:Bile Canaliculi / Q000473:pathology / Q000648:ultrastructure; D017809:Fatal Outcome; D006801:Humans; D007181:Inclusion Bodies, Viral; D008099:Liver / Q000648:ultrastructure*; D008297:Male; D008871:Microvilli; D008875:Middle Aged; D010588:Phagosomes; D012295:Rift Valley Fever / Q000473:pathology* / Q000821:virology; D012296:Rift Valley fever virus; D012529:Saudi Arabia; D014771:Virion