title: Association of XPC Gene Polymorphisms with Prostate Cancer Risk.
abstract: BACKGROUND
  Defective DNA repair capacity caused by inherited polymorphisms could be associated with cancer susceptibility. One of the major repair pathways is Nucleotide Excision Repair (NER). We investigated Xeroderma Pigmentosum complementation group C (XPC) polymorphisms (Lys939Gln, PAT) with the risk of prostate cancer.
  
  
  METHODS
  154 confirmed prostate cancer patients and 205 Benign Prostate Hyperplasia (BPH) controls were recruited in this survey. The genotypes were determined by PCR-Restriction Fragment Length Polymorphism (RFLP) method.
  
  
  RESULTS
  Our results indicated that there were no significant differences between the BPH group and patient group for the XPC Lys939Gln in this pathway. However, deletion/insertion (D/I) and insertion/insertion (I/I) of XPC PAT polymorphism in this pathway could decrease the risk of prostate cancer and act as a protective factor.
  
  
  CONCLUSIONS
  In this study, XPC Lys939Gln gene polymorphism was not associated with the risk of developing prostate cancer in Iranian patients. There are no association between different alleles of this polymorphism and grades and stages of tumors, but our results indicated the significant association between XPC PAT and reduction of prostate cancer risk in this group of patients. For more significant results, further samples are required.
authors.forename: Shima A
authors.initials: SA
authors.lastname: Kahnamouei
authors.forename: Behzad
authors.initials: B
authors.lastname: Narouie
authors.forename: Mehdi
authors.initials: M
authors.lastname: Sotoudeh
authors.forename: Mohammad J
authors.initials: MJ
authors.lastname: Mollakouchekian
authors.forename: Nasser
authors.initials: N
authors.lastname: Simforoosh
authors.forename: Seyed A M
authors.initials: SA
authors.lastname: Ziaee
authors.forename: Mohammad
authors.initials: M
authors.lastname: Samzadeh
authors.forename: Mahdi
authors.initials: M
authors.lastname: Afshari
authors.forename: Seyed H
authors.initials: SH
authors.lastname: Jamaldini
authors.forename: Mahdieh
authors.initials: M
authors.lastname: Imeni
authors.forename: Mandana
authors.initials: M
authors.lastname: Hasanzad
mesh_terms: D000368:Aged; D014408:Biomarkers, Tumor / Q000235:genetics*; D016022:Case-Control Studies; D004268:DNA-Binding Proteins / Q000235:genetics*; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D007492:Iran / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D060787:Neoplasm Grading; D009367:Neoplasm Staging; D010641:Phenotype; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D011471:Prostatic Neoplasms / Q000201:enzymology / Q000453:epidemiology / Q000235:genetics* / Q000473:pathology; D065840:Protective Factors; D018570:Risk Assessment; D012307:Risk Factors
chemical_list: D014408:Biomarkers, Tumor; D004268:DNA-Binding Proteins; C086984:XPC protein, human