title: SYSTEMIC HISTIOCYTIC SARCOMA IN A COMMON HIPPOPOTAMUS (HIPPOPOTAMUS AMPHIBIUS).
abstract: A 37-yr-old captive common hippopotamus (Hippopotamus amphibius) developed lethargy and decline in mobility that progressed to death, despite supportive therapy. Histopathologic examination revealed severe, diffuse, intravascular and interstitial infiltration of neoplastic histiocytes in the spleen, liver, lymph nodes, lungs, large intestine, kidneys, and thyroid gland. Neoplastic cells were pleomorphic with marked anisocytosis and anisokaryosis, scattered multinucleated giant cells, numerous bizarre mitotic figures, and marked erythrophagocytosis. Immunohistochemistry demonstrated that neoplastic cells were positive for ionized calcium-binding adapter molecule 1 (a histiocytic marker) and negative for CD3 (a T-cell marker) and myeloperoxidase, confirming the diagnosis of systemic histiocytic sarcoma.
authors.forename: Luciana Fachini
authors.initials: LF
authors.lastname: da Costa
authors.forename: Marcelo Campos Cordeiro
authors.initials: MC
authors.lastname: Malta
authors.forename: Herlandes Penha
authors.initials: HP
authors.lastname: Tinoco
authors.forename: Lilian Botelho
authors.initials: LB
authors.lastname: de Medeiros
authors.forename: Ana Luiza Sarkis Vieira
authors.initials: AL
authors.lastname: Bittar
authors.forename: Aline Rodrigues
authors.initials: AR
authors.lastname: Hoffmann
authors.forename: Felipe
authors.initials: F
authors.lastname: Pierezan
authors.forename: Tatiane Alves
authors.initials: TA
authors.lastname: da Paixão
authors.forename: Renato Lima
authors.initials: RL
authors.lastname: Santos
mesh_terms: D000818:Animals; D001188:Artiodactyla; D017809:Fatal Outcome; D005260:Female; D054747:Histiocytic Sarcoma / Q000473:pathology / Q000662:veterinary*
keywords: Hippopotamus; Hippopotamus amphibius; malignant histiocytosis; neoplasia; systemic histiocytic sarcoma