title: Voxel-based morphometry to detect effect of APOE on brain gray matter changes in Parkinson's Disease.
abstract: The goal of the study was to determine association between APOE Ɛ4 and gray matter changes in PD patients, with or without dementia. Twenty-five PD patients with the APOE Ɛ4 (13 with dementia), 24 without Ɛ4 (12 with dementia), and 26 controls were selected. We found no significant differences between PD patients and controls, or between PD patients with and without the APOE Ɛ4 allele, with regard to VBM analysis. Our results provide no evidence of an association of the APOE Ɛ4 and gray matter degenerative changes in patients with PD, either with or without dementia.
authors.affiliation: Institute of Molecular Bioimaging and Physiology of the National Research Council (IBFM-CNR), University Magna Graecia, Catanzaro, Italy. Electronic address: g.nicoletti@unicz.it.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Nicoletti
authors.affiliation: Functional MR Unit, Departmentof Biomedical and NeuroMotor Sciences (DiBiNeM), University of Bologna, Italy. Electronic address: davidneil.manners@unibo.it.
authors.forename: David Neil
authors.initials: DN
authors.lastname: Manners
authors.affiliation: Institute of Molecular Bioimaging and Physiology of the National Research Council (IBFM-CNR), University Magna Graecia, Catanzaro, Italy.
authors.forename: Fabiana
authors.initials: F
authors.lastname: Novellino
authors.affiliation: Functional MR Unit, Departmentof Biomedical and NeuroMotor Sciences (DiBiNeM), University of Bologna, Italy.
authors.forename: Claudia
authors.initials: C
authors.lastname: Testa
authors.affiliation: Institute of Molecular Bioimaging and Physiology of the National Research Council (IBFM-CNR), University Magna Graecia, Catanzaro, Italy.
authors.forename: Monica
authors.initials: M
authors.lastname: Gagliardi
authors.affiliation: Functional MR Unit, Departmentof Biomedical and NeuroMotor Sciences (DiBiNeM), University of Bologna, Italy.
authors.forename: Caterina
authors.initials: C
authors.lastname: Tonon
authors.affiliation: Functional MR Unit, Departmentof Biomedical and NeuroMotor Sciences (DiBiNeM), University of Bologna, Italy.
authors.forename: Raffaele
authors.initials: R
authors.lastname: Lodi
authors.affiliation: Institute of Molecular Bioimaging and Physiology of the National Research Council (IBFM-CNR), University Magna Graecia, Catanzaro, Italy; Institute of Neurology, University "Magna Graecia", Catanzaro, Italy.
authors.forename: Aldo
authors.initials: A
authors.lastname: Quattrone
mesh_terms: D000368:Aged; D000483:Alleles; D053327:Apolipoprotein E4 / Q000235:genetics; D001057:Apolipoproteins E; D001921:Brain / Q000000981:diagnostic imaging* / Q000473:pathology; D016022:Case-Control Studies; D003704:Dementia / Q000000981:diagnostic imaging* / Q000235:genetics / Q000473:pathology / Q000523:psychology; D005260:Female; D066128:Gray Matter / Q000000981:diagnostic imaging* / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000000981:diagnostic imaging* / Q000235:genetics / Q000473:pathology / Q000523:psychology
chemical_list: D053327:Apolipoprotein E4; D001057:Apolipoproteins E