title: Circulating Prolactin and Risk of Type 2 Diabetes: A Prospective Study.
abstract: Prolactin plays an important role in maintaining a normal glucose homeostasis during pregnancy and beyond. Studies investigating the association between prolactin and type 2 diabetes beyond pregnancy are rare and none is prospective. We aimed to examine whether prolactin associates with type 2 diabetes prospectively in a Chinese population. In 2009, 2,377 participants aged 40 years or older were enrolled from Shanghai, China. Among 1,596 diabetes-free participants at baseline, 1,510 completed the follow-up investigation in 2013. Participants who had a fasting plasma glucose ≥126 mg/dL and/or a 2-hour plasma glucose ≥200 mg/dL during a 75-g oral glucose tolerance test had a definite diagnosis of type 2 diabetes or received antidiabetic therapies during follow-up were classified as having type 2 diabetes. During a mean follow-up of 3.7 years, 189 new cases of type 2 diabetes were documented. After multivariate adjustment, women in the highest quartile of prolactin showed the lowest risk for diabetes compared with those in the lowest quartile (hazard ratio = 0.48, 95% confidence interval: 0.26, 0.90). However, such significant associations were not observed in men. Prolactin may be a mediator in the pathogenesis of type 2 diabetes in women; however, more studies are needed to elucidate the underlying sex-specific mechanism.
authors.forename: Tiange
authors.initials: T
authors.lastname: Wang
authors.forename: Yu
authors.initials: Y
authors.lastname: Xu
authors.forename: Min
authors.initials: M
authors.lastname: Xu
authors.forename: Guang
authors.initials: G
authors.lastname: Ning
authors.forename: Jieli
authors.initials: J
authors.lastname: Lu
authors.forename: Meng
authors.initials: M
authors.lastname: Dai
authors.forename: Baihui
authors.initials: B
authors.lastname: Xu
authors.forename: Jichao
authors.initials: J
authors.lastname: Sun
authors.forename: Wanwan
authors.initials: W
authors.lastname: Sun
authors.forename: Shenghan
authors.initials: S
authors.lastname: Lai
authors.forename: Yufang
authors.initials: Y
authors.lastname: Bi
authors.forename: Weiqing
authors.initials: W
authors.lastname: Wang
mesh_terms: D000328:Adult; D000368:Aged; D001786:Blood Glucose / Q000378:metabolism*; D002681:China / Q000453:epidemiology; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000453:epidemiology; D005260:Female; D005951:Glucose Tolerance Test; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D010298:Parity; D017698:Postmenopause / Q000097:blood; D011388:Prolactin / Q000097:blood*; D011446:Prospective Studies; D012044:Regression Analysis; D012307:Risk Factors
chemical_list: D001786:Blood Glucose; D011388:Prolactin
keywords: prolactin; prospective study; type 2 diabetes