title: Acute lymphoblastic leukemia with e1a3 BCR/ABL fusion protein. A report of two cases.
abstract: B Acute Lymphoblastic leukemia (B-ALL) with Philadelphia chromosome (Ph') is a neoplasm of lymphoblast committed to the B cell lineage. The clinical presentation of B-ALL Ph'+ is similar to B-ALL, but is more common in adults than in children. The e1a3 rare variant is produced by the fusion of BCR exon 1 to ABL exon 3. The presence of this translocation has been associated with good disease outcome for chronic myeloid leukemia in a very small series of only 5 cases; there is no such evidence for B-ALL. We report two new cases of B-ALL Ph+ with the rare e1a3 fusion transcript. The e1a3 and e1a2 (p190) transcripts have been reported to have a similar molecular weight and probably a similar clinical profile, thus in these cases the presence of e1a3 was associated with extramedullary infiltration and disease acceleration.
authors.affiliation: Department of Hematology, University Hospital Son Espases, Palma de Mallorca, Spain.
authors.forename: Bernardo
authors.initials: B
authors.lastname: López-Andrade
authors.affiliation: Department of Hematology, University Hospital Son Espases, Palma de Mallorca, Spain.
authors.forename: Francesca
authors.initials: F
authors.lastname: Sartori
authors.affiliation: Department of Hematology, University Hospital Son Espases, Palma de Mallorca, Spain.|Instituto de Investigación Sanitaria de Palma (IdISPa), Palma de Mallorca, Spain.
authors.forename: Antonio
authors.initials: A
authors.lastname: Gutiérrez
authors.affiliation: Department of Hematology, University Hospital Son Espases, Palma de Mallorca, Spain.
authors.forename: Lucia
authors.initials: L
authors.lastname: García
authors.affiliation: Department of Immunology, University Hospital Son Espases, Palma de Mallorca, Spain.
authors.forename: Vanesa
authors.initials: V
authors.lastname: Cunill
authors.affiliation: Department of Hematology, University Hospital Son Espases, Palma de Mallorca, Spain.
authors.forename: María Antonia
authors.initials: MA
authors.lastname: Durán
authors.affiliation: Department of Hematology, University Hospital Son Espases, Palma de Mallorca, Spain.|Instituto de Investigación Sanitaria de Palma (IdISPa), Palma de Mallorca, Spain.
authors.forename: Antonia
authors.initials: A
authors.lastname: Sampol
authors.affiliation: Department of Genetics, University Hospital Son Espases, Palma de Mallorca, Spain.
authors.forename: Marta
authors.initials: M
authors.lastname: Bernués
authors.affiliation: Department of Immunology, University Hospital Son Espases, Palma de Mallorca, Spain.
authors.forename: Julio
authors.initials: J
authors.lastname: Iglesias
authors.affiliation: Department of Pathology, University Hospital Son Espases, Palma de Mallorca, Spain.
authors.forename: Rafael
authors.initials: R
authors.lastname: Ramos
authors.affiliation: Department of Hematology, University Hospital Son Espases, Palma de Mallorca, Spain.
authors.forename: Josep
authors.initials: J
authors.lastname: Lladó
authors.affiliation: Department of Hematology, University Hospital Son Espases, Palma de Mallorca, Spain.
authors.forename: María
authors.initials: M
authors.lastname: Sánchez
authors.affiliation: Department of Hematology, University Hospital Son Espases, Palma de Mallorca, Spain.
authors.forename: Juan Carlos
authors.initials: JC
authors.lastname: Amat
authors.affiliation: Department of Hematology, University Hospital Son Espases, Palma de Mallorca, Spain.|Instituto de Investigación Sanitaria de Palma (IdISPa), Palma de Mallorca, Spain.
authors.forename: Jordi
authors.initials: J
authors.lastname: Martínez-Serra