title: Cranberry extract supplementation exerts preventive effects through alleviating Aβ toxicity in Caenorhabditis elegans model of Alzheimer's disease.
abstract: Cranberry extract (CBE) rich in polyphenols are potent to delay paralysis induced by alleviating β-amyloid (Aβ) toxicity in C. elegans model of Alzheimer's disease (AD). In order to better apply CBE as an anti-AD agent efficiently, we sought to deterrmine whether preventive or therapeutic effect contributes more prominently toward CBE's anti-AD activity. As the level of Aβ toxicity and memory health are two major pathological parameters in AD, in the present study, we compared the effects of CBE on Aβ toxicity and memory health in the C. elegans AD model treated with preventive and therapeutic protocols. Our results revealed that CBE prominently showed the preventive efficacy, providing a basis for further investigation of these effects in mammals.
authors.affiliation: School of Life Science and Technology, China Pharmaceutical University, Nanjing 210009, China; Department of Biological Sciences, Clemson University, Clemson, SC 29634, USA.
authors.forename: Hong
authors.initials: H
authors.lastname: Guo
authors.affiliation: Department of Biological Sciences, Clemson University, Clemson, SC 29634, USA; Institute for Engaged Aging, Clemson University, Clemson, SC 29634, USA. Electronic address: ydong@clemson.edu.
authors.forename: Yu-Qing
authors.initials: YQ
authors.lastname: Dong
authors.affiliation: School of Life Science and Technology, China Pharmaceutical University, Nanjing 210009, China. Electronic address: yebp@cpu.edu.cn.
authors.forename: Bo-Ping
authors.initials: BP
authors.lastname: Ye
mesh_terms: D000544:Alzheimer Disease / Q000188:drug therapy* / Q000235:genetics / Q000378:metabolism / Q000523:psychology; D016229:Amyloid beta-Peptides / Q000378:metabolism / Q000633:toxicity*; D000818:Animals; D017173:Caenorhabditis elegans / Q000187:drug effects* / Q000378:metabolism; D019587:Dietary Supplements / Q000032:analysis*; D004195:Disease Models, Animal; D005260:Female; D005638:Fruit / Q000737:chemistry; D006801:Humans; D008297:Male; D008568:Memory / Q000187:drug effects; D010936:Plant Extracts / Q000008:administration & dosage*; D029799:Vaccinium macrocarpon / Q000737:chemistry*
chemical_list: D016229:Amyloid beta-Peptides; D010936:Plant Extracts
keywords: Aβ toxicity; Body paralysis; Caenorhabditis elegans; Cranberry polyphenols; Prevention