title: Role of NK, NKT cells and macrophages in liver transplantation.
abstract: Liver transplantation has become the treatment of choice for acute or chronic liver disease. Because the liver acts as an innate immunity-dominant organ, there are immunological differences between the liver and other organs. The specific features of hepatic natural killer (NK), NKT and Kupffer cells and their role in the mechanism of liver transplant rejection, tolerance and hepatic ischemia-reperfusion injury are discussed in this review.
authors.affiliation: René Fahrner, Felix Dondorf, Michael Ardelt, Utz Settmacher, Falk Rauchfuss, Department of General, Visceral and Vascular Surgery, Jena University Hospital, 07747 Jena, Germany.
authors.forename: René
authors.initials: R
authors.lastname: Fahrner
authors.affiliation: René Fahrner, Felix Dondorf, Michael Ardelt, Utz Settmacher, Falk Rauchfuss, Department of General, Visceral and Vascular Surgery, Jena University Hospital, 07747 Jena, Germany.
authors.forename: Felix
authors.initials: F
authors.lastname: Dondorf
authors.affiliation: René Fahrner, Felix Dondorf, Michael Ardelt, Utz Settmacher, Falk Rauchfuss, Department of General, Visceral and Vascular Surgery, Jena University Hospital, 07747 Jena, Germany.
authors.forename: Michael
authors.initials: M
authors.lastname: Ardelt
authors.affiliation: René Fahrner, Felix Dondorf, Michael Ardelt, Utz Settmacher, Falk Rauchfuss, Department of General, Visceral and Vascular Surgery, Jena University Hospital, 07747 Jena, Germany.
authors.forename: Utz
authors.initials: U
authors.lastname: Settmacher
authors.affiliation: René Fahrner, Felix Dondorf, Michael Ardelt, Utz Settmacher, Falk Rauchfuss, Department of General, Visceral and Vascular Surgery, Jena University Hospital, 07747 Jena, Germany.
authors.forename: Falk
authors.initials: F
authors.lastname: Rauchfuss
mesh_terms: D006084:Graft Rejection / Q000276:immunology*; D006801:Humans; D007108:Immune Tolerance / Q000276:immunology; D007694:Killer Cells, Natural / Q000276:immunology*; D007728:Kupffer Cells / Q000276:immunology*; D008107:Liver Diseases / Q000276:immunology*; D016031:Liver Transplantation; D008264:Macrophages / Q000276:immunology; D055611:Natural Killer T-Cells / Q000276:immunology*; D015427:Reperfusion Injury / Q000276:immunology*
keywords: Graft rejection; Ischemia-reperfusion injury; Kupffer cells; Liver transplantation; Natural killer cells