title: Development of rheumatoid arthritis during treatment of multiple sclerosis with interferon beta 1-a. Coincidence of two conditions or a complication of treatment: A case report.
abstract: Coexistence of multiple sclerosis (MS) with other autoimmune diseases has been attributed to common background genetic or environmental factors. This study presents development of rheumatoid arthritis (RA) during treatment of MS. The MS was confirmed by the Mc Donald criteria and the diagnosis of RA was confirmed by the ACR/EULAR criteria. A 35 years old women with 9 years of MS who was receiving interferon beta 1-a (INF) for 7 years and who did not respond to conventional therapy of RA over 8 months developed clinical manifestations of RA. But a rapid response was observed after discontinuation of INF. These findings suggest a possible contribution of INF in the development of RA.
authors.affiliation: Departments of Neurology, Rouhani Hospital, Babol University of Medical Sciences, Babol, Iran; Clinical Research Development Unit of Rouhani Hospital, Babol University of Medical Sciences, Babol, Iran.
authors.forename: Seyed Mohammad Masood
authors.initials: SM
authors.lastname: Hojjati
authors.affiliation: Clinical Research Development Unit of Rouhani Hospital, Babol University of Medical Sciences, Babol, Iran; Department of Internal Medicine, Division of Rheumatology, Rouhani Hospital, Babol University of Medical Sciences, Babol, Iran.
authors.forename: Behzad
authors.initials: B
authors.lastname: Heidari
authors.affiliation: Clinical Research Development Unit of Rouhani Hospital, Babol University of Medical Sciences, Babol, Iran; Department of Internal Medicine, Division of Rheumatology, Rouhani Hospital, Babol University of Medical Sciences, Babol, Iran.
authors.forename: Mansour
authors.initials: M
authors.lastname: Babaei
keywords: Coexistence; Interferon beta 1-a; Multiple sclerosis; Rheumatoid arthritis