title: Association of Polymorphisms within the Serotonin Receptor Genes 5-HTR1A, 5-HTR1B, 5-HTR2A and 5-HTR2C and Migraine Susceptibility in a Turkish Population.
abstract: OBJECTIVE
  Migraine, a highly prevelant headache disorder, is regarded as a polygenic multifactorial disease. Serotonin (5-HT) and their respective receptors have been implicated in the patogenesis.
  
  
  METHODS
  We investigated the 5-HT1A, 5-HT1B, 5-HT2A, and 5-HT2C receptor gene polymorphisms and their association with migraine in Turkish patients. The rs6295, rs1300060, rs1228814, rs6311, rs6313, rs6314, rs6318, rs3813929 (-759C/T) and rs518147 polymorphisms were analyzed in 135 patients with migraine and 139 healthy subjects, using a BioMark 96.96 dynamic array system.
  
  
  RESULTS
  We found no difference in the frequency of the analyzed eight out of nine polymorpisms between migraine and control groups. However, a significant association was found between the rs3813929 polymorphism in the promoter region of 5-HTR2C gene and migraine. Also, the allele of rs3813929 was more common in the migraine group.
  
  
  CONCLUSIONS
  This result suggests that the 5-HTR2C rs3813929 polymorphism can be a genetic risk factor for migraine in a Turkish population.
authors.affiliation: Department of Neurology, Dicle University, Medical Faculty, Diyarbakır, Turkey.
authors.forename: Yavuz
authors.initials: Y
authors.lastname: Yücel
authors.affiliation: Department of Medical Genetics, Dicle University, Medical Faculty, Diyarbakır, Turkey.
authors.forename: Salih
authors.initials: S
authors.lastname: Coşkun
authors.affiliation: Department of Medical Genetics, Medical Faculty, Gazi University, Ankara, Turkey.
authors.forename: Beyhan
authors.initials: B
authors.lastname: Cengiz
authors.affiliation: Department of Neurology, Dicle University, Medical Faculty, Diyarbakır, Turkey.
authors.forename: Hasan H
authors.initials: HH
authors.lastname: Özdemir
authors.affiliation: Department of Neurology, Dicle University, Medical Faculty, Diyarbakır, Turkey.
authors.forename: Ertuğrul
authors.initials: E
authors.lastname: Uzar
authors.affiliation: Department of Medical Genetics, Dicle University, Medical Faculty, Diyarbakır, Turkey.
authors.forename: Abdullah
authors.initials: A
authors.lastname: Çim
authors.affiliation: Department of Psychiatry, Afsin State Hospital, Kahramanmaras, Turkey.
authors.forename: M Akif
authors.initials: MA
authors.lastname: Camkurt
authors.affiliation: Department of Neurology, Dicle University, Medical Faculty, Diyarbakır, Turkey.
authors.forename: M Ufuk
authors.initials: MU
authors.lastname: Aluclu
keywords: 5-HT2C; Genetic association studies; Headache; Migraine disorders; Receptor; Single nucleotide polymorphism; serotonin