title: Changing of IKZF1 genotype during Philadelphia-negative precursor-B acute lymphoblastic leukemia progression: a short clinical report.
abstract: •The case demonstrated a rare event of clonal heterogeneity by IKZF1 gene status in BCRABL1- ALL.•IKZF1 deletions are secondary events in ALL caused by clonal evolution during the treatment.•It's prognostic significance could be more crucial in BCR-ABL- rather than in BCR-ABL + ALL.•IKZF1 gene alterations may be determined and proved at the genome, expression and protein level.•IKZF1 deletions are suitable for MRD detection but not stable compared to Ig/TCR rearrangement.
authors.affiliation: Belarusian Research Centre for Pediatric Oncology, Hematology and Immunology, 223053, Republic of Belarus, Minsk region, v. Borovlyani, Frunzenskaya st., 43, Belarus.
authors.forename: Volha
authors.initials: V
authors.lastname: Vshyukova
authors.affiliation: Belarusian Research Centre for Pediatric Oncology, Hematology and Immunology, 223053, Republic of Belarus, Minsk region, v. Borovlyani, Frunzenskaya st., 43, Belarus.
authors.forename: Alexander
authors.initials: A
authors.lastname: Meleshko
authors.affiliation: Belarusian Research Centre for Pediatric Oncology, Hematology and Immunology, 223053, Republic of Belarus, Minsk region, v. Borovlyani, Frunzenskaya st., 43, Belarus.
authors.forename: Natalia
authors.initials: N
authors.lastname: Mihal
authors.affiliation: Belarusian Research Centre for Pediatric Oncology, Hematology and Immunology, 223053, Republic of Belarus, Minsk region, v. Borovlyani, Frunzenskaya st., 43, Belarus.
authors.forename: Olga
authors.initials: O
authors.lastname: Aleinikova