title: Vibrational Analysis of Lung Tumor Cell Lines: Implementation of an Invasiveness Scale Based on the Cell Infrared Signatures.
abstract: Assessing the tumor invasiveness is a paramount diagnostic step to improve the patients care. Infrared spectroscopy access the chemical composition of samples; and in combination with statistical multivariate processing, presents the capacity to highlight subtle molecular alterations associated with malignancy development. Our investigation demonstrated that infrared signatures of cell lines presenting various invasiveness phenotypes contain discriminant spectral features, which are useful informative signals to implement an objective invasiveness scale. This last development reflects the interest of vibrational approach as a candidate biophotonic label-free technique, usable in routine clinics, to characterize quantitatively tumor aggressiveness. In addition, the methodology can reveal the heterogeneity of cancer cells, opening the way to further researches in cancer science.
authors.affiliation: Equipe MéDIAN-Biophotonique et Technologies pour la Santé Université de Reims Champagne-Ardenne, UFR de Pharmacie, 51 rue Cognacq-Jay, 51096 Reims, France.|CNRS UMR 7369 MEDyC, SFR Cap-Santé, 51 rue Cognacq-Jay, 51096 Reims, France.
authors.forename: Vincent
authors.initials: V
authors.lastname: Gaydou
authors.affiliation: INSERM UMR-S 903, SFR CAP-Santé, University of Reims-Champagne-Ardenne , 45, rue Cognacq-Jay, 51092 Reims, France.|Biopathology Laboratory, Centre Hospitalier et Universitaire de Reims , 45 Rue Cognacq-Jay, 51092 Reims, France.|Platform of Cellular and Tissular Imaging (PICT), Université de Reims Champagne-Ardenne , 51 rue Cognacq-Jay, 51096 Reims, France.
authors.forename: Myriam
authors.initials: M
authors.lastname: Polette
authors.affiliation: Equipe MéDIAN-Biophotonique et Technologies pour la Santé Université de Reims Champagne-Ardenne, UFR de Pharmacie, 51 rue Cognacq-Jay, 51096 Reims, France.|CNRS UMR 7369 MEDyC, SFR Cap-Santé, 51 rue Cognacq-Jay, 51096 Reims, France.|Platform of Cellular and Tissular Imaging (PICT), Université de Reims Champagne-Ardenne , 51 rue Cognacq-Jay, 51096 Reims, France.
authors.forename: Cyril
authors.initials: C
authors.lastname: Gobinet
authors.affiliation: INSERM UMR-S 903, SFR CAP-Santé, University of Reims-Champagne-Ardenne , 45, rue Cognacq-Jay, 51092 Reims, France.|Biopathology Laboratory, Centre Hospitalier et Universitaire de Reims , 45 Rue Cognacq-Jay, 51092 Reims, France.
authors.forename: Claire
authors.initials: C
authors.lastname: Kileztky
authors.affiliation: Equipe MéDIAN-Biophotonique et Technologies pour la Santé Université de Reims Champagne-Ardenne, UFR de Pharmacie, 51 rue Cognacq-Jay, 51096 Reims, France.|CNRS UMR 7369 MEDyC, SFR Cap-Santé, 51 rue Cognacq-Jay, 51096 Reims, France.
authors.forename: Jean-François
authors.initials: JF
authors.lastname: Angiboust
authors.affiliation: Equipe MéDIAN-Biophotonique et Technologies pour la Santé Université de Reims Champagne-Ardenne, UFR de Pharmacie, 51 rue Cognacq-Jay, 51096 Reims, France.|CNRS UMR 7369 MEDyC, SFR Cap-Santé, 51 rue Cognacq-Jay, 51096 Reims, France.
authors.forename: Michel
authors.initials: M
authors.lastname: Manfait
authors.affiliation: INSERM UMR-S 903, SFR CAP-Santé, University of Reims-Champagne-Ardenne , 45, rue Cognacq-Jay, 51092 Reims, France.|Biopathology Laboratory, Centre Hospitalier et Universitaire de Reims , 45 Rue Cognacq-Jay, 51092 Reims, France.
authors.forename: Philippe
authors.initials: P
authors.lastname: Birembaut
authors.affiliation: Equipe MéDIAN-Biophotonique et Technologies pour la Santé Université de Reims Champagne-Ardenne, UFR de Pharmacie, 51 rue Cognacq-Jay, 51096 Reims, France.|CNRS UMR 7369 MEDyC, SFR Cap-Santé, 51 rue Cognacq-Jay, 51096 Reims, France.|Platform of Cellular and Tissular Imaging (PICT), Université de Reims Champagne-Ardenne , 51 rue Cognacq-Jay, 51096 Reims, France.
authors.forename: Olivier
authors.initials: O
authors.lastname: Piot
mesh_terms: D000465:Algorithms; D006801:Humans; D008175:Lung Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology*; D009361:Neoplasm Invasiveness / Q000000981:diagnostic imaging* / Q000473:pathology*; D013055:Spectrophotometry, Infrared / Q000295:instrumentation; D014407:Tumor Cells, Cultured; D014732:Vibration