title: Mortality in Mild Cognitive Impairment: A Longitudinal Study in Memory Clinics.
abstract: Patients with mild cognitive impairment (MCI) are at greater risk of mortality than the general population. Comparatively little research has examined predictors of mortality in MCI and no research has examined whether time-varying variables, such as change in cognition and function, predict survival.
  
  
  
  To identify predictors of mortality in patients with MCI.
  
  
  
  185 patients with MCI were recruited from nine memory clinics around Australia. Patients completed measures of cognition, function, and neuropsychiatric symptoms over three years. Mortality data were obtained from state registries eight years after baseline.
  
  
  
  55 (30%) patients died within this period. Older age, lower cognitive and functional ability at baseline, and greater decline in functional ability over six months predicted mortality.
  
  
  
  Easily measurable clinical data predict mortality in patients with MCI. Longitudinal assessment over time can provide additional information about patients' risk.
authors.affiliation: Dementia Collaborative Research Centre, School of Psychiatry, UNSW Australia, Sydney, Australia.|Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Sydney, Australia.
authors.forename: Michael H
authors.initials: MH
authors.lastname: Connors
authors.affiliation: Academic Unit for Psychiatry of Old Age, University of Melbourne, Melbourne, Australia.|National Ageing Research Institute, Melbourne, Australia.
authors.forename: David
authors.initials: D
authors.lastname: Ames
authors.affiliation: Queen Elizabeth Hospital, Adelaide, Australia.
authors.forename: Karyn
authors.initials: K
authors.lastname: Boundy
authors.affiliation: School of Medicine and Pharmacology, University of Western Australia, Crawley, Australia.
authors.forename: Roger
authors.initials: R
authors.lastname: Clarnette
authors.affiliation: Sydney Medical School, University of Sydney, Sydney, Australia.
authors.forename: Sue
authors.initials: S
authors.lastname: Kurrle
authors.affiliation: Faculty of Health, Deakin University, Geelong, Australia.
authors.forename: Alastair
authors.initials: A
authors.lastname: Mander
authors.affiliation: School of Medicine and Population Health, University of Newcastle, Newcastle, Australia.
authors.forename: John
authors.initials: J
authors.lastname: Ward
authors.affiliation: Austin Hospital, Heidelberg, Australia.
authors.forename: Michael
authors.initials: M
authors.lastname: Woodward
authors.affiliation: Dementia Collaborative Research Centre, School of Psychiatry, UNSW Australia, Sydney, Australia.|Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Sydney, Australia.
authors.forename: Henry
authors.initials: H
authors.lastname: Brodaty
mesh_terms: D000367:Age Factors; D000368:Aged; D001315:Australia; D060825:Cognitive Dysfunction / Q000401:mortality* / Q000628:therapy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D000073216:Mental Status and Dementia Tests; D016016:Proportional Hazards Models; D012307:Risk Factors; D012737:Sex Factors
keywords: Lifespan; longitudinal studies; mild cognitive impairment; mortality; risk factors; survival