title: Changes in serum lipid profile in the acute and convalescent Plasmodium vivax malaria: A cohort study.
abstract: Although serum lipids are known to be altered in Plasmodium falciparum-induced malaria, little is known about such changes due to Plasmodium vivax infection. This cohort study assessed serum concentrations of triglycerides, total cholesterol, low-density lipoprotein (LDL), and high-density lipoprotein (HDL) in 164 patients in the acute phase of malaria caused by P. vivax and characterized these changes in the convalescent phase after treatment with chloroquine and primaquine. Compared to reference values, serum total cholesterol, LDL, and HDL levels were lower and triglyceride levels were higher in the acute phase. Moreover, the parasite density was negatively correlated with LDL (r=-0,189; p=0.027) and HDL (r=-0,256; p=0.001) serum levels. Eighty patients returned for clinical and laboratory revaluation 7-12days after treatment initiation. All patients showed parasite clearance and the absence of symptoms during the convalescent phase. Analysis of the serum lipids of these 80 patients showed significant increases in the serum levels of total cholesterol (p<0.0001), LDL (p<0.0001), and HDL (p<0.0001) as well as a significant reduction in triglycerides (p=0.004), indicating a trend towards a return to normal levels. This transient change in lipid profile between the acute and convalescent stages may be useful for the clinical monitoring of patients treated for vivax malaria.
authors.affiliation: Hospital Universitário Júlio Müller, Universidade Federal de Mato Grosso, Rua Dr. Luiz Philipe Pereira Leite sn, Bairro Alvorada, Cuiabá (MT), CEP: 78048-902, Brazil.
authors.forename: Teresinha C
authors.initials: TC
authors.lastname: Mesquita
authors.affiliation: Hospital Universitário Júlio Müller, Universidade Federal de Mato Grosso, Rua Dr. Luiz Philipe Pereira Leite sn, Bairro Alvorada, Cuiabá (MT), CEP: 78048-902, Brazil.
authors.forename: Thamires G O
authors.initials: TG
authors.lastname: Martin
authors.affiliation: Centro Universitário UNIVAG, Curso de Biomedicina, Av Dom Orlando Chaves 2655, Bairro Cristo Rei, Várzea Grande (MT), CEP: 78118-000, Brazil.
authors.forename: Eduardo R
authors.initials: ER
authors.lastname: Alves
authors.affiliation: Hospital Universitário Júlio Müller, Universidade Federal de Mato Grosso, Rua Dr. Luiz Philipe Pereira Leite sn, Bairro Alvorada, Cuiabá (MT), CEP: 78048-902, Brazil.
authors.forename: Marcia B C
authors.initials: MB
authors.lastname: Mello
authors.affiliation: Hospital Universitário Júlio Müller, Universidade Federal de Mato Grosso, Rua Dr. Luiz Philipe Pereira Leite sn, Bairro Alvorada, Cuiabá (MT), CEP: 78048-902, Brazil; Faculdade de Ciências Biomédicas de Cacoal, Av. Cuiabá 3087, Bairro Jd Clodoaldo, Cacoal (RO), CEP: 76.963-665, Brazil.
authors.forename: Andreia F
authors.initials: AF
authors.lastname: Nery
authors.affiliation: Hospital Universitário Júlio Müller, Universidade Federal de Mato Grosso, Rua Dr. Luiz Philipe Pereira Leite sn, Bairro Alvorada, Cuiabá (MT), CEP: 78048-902, Brazil.
authors.forename: Luciano T
authors.initials: LT
authors.lastname: Gomes
authors.affiliation: Hospital Universitário Júlio Müller, Universidade Federal de Mato Grosso, Rua Dr. Luiz Philipe Pereira Leite sn, Bairro Alvorada, Cuiabá (MT), CEP: 78048-902, Brazil. Electronic address: corfontes@gmail.com.
authors.forename: Cor Jesus F
authors.initials: CJ
authors.lastname: Fontes
mesh_terms: D000293:Adolescent; D000328:Adult; D000962:Antimalarials / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D002738:Chloroquine / Q000627:therapeutic use; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D015331:Cohort Studies; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D016780:Malaria, Vivax / Q000097:blood / Q000188:drug therapy / Q000534:rehabilitation*; D008297:Male; D008875:Middle Aged; D011319:Primaquine / Q000627:therapeutic use; D014280:Triglycerides / Q000097:blood; D055815:Young Adult
chemical_list: D000962:Antimalarials; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D014280:Triglycerides; D002738:Chloroquine; D002784:Cholesterol; D011319:Primaquine
keywords: Lipids; Malaria; Plasmodium vivax