title: The changes of subtypes in pediatric diabetes and their clinical and laboratory characteristics over the last 20 years.
abstract: OBJECTIVE
  We studied the changes in subtypes of diabetes mellitus (DM) in children and evaluated the characteristics of each group over the past 20 years. In addition, we also examined the correlation between the glycated hemoglobin (HbA1c) values at the time of diagnosis and lipid profiles.
  
  
  METHODS
  The patients were divided into 2 groups: there were a total of 190 patients under 20 years of age firstly diagnosed with DM in Ajou University Hospital. The patients in groups I and II were diagnosed from September 1995 to December 2004 and from January 2005 to April 2014, respectively.
  
  
  RESULTS
  The characteristics were compared between the 2 groups of patients. The result showed an increase in percentage of type 2 diabetes and maturity onset diabetes of the young (MODY) patients between the 2 groups. HbA1c and total cholesterol level had statistical significances to explain increasing the low-density lipoprotein cholesterol level among age, HbA1c, total cholesterol level, and z-scores of weight and body mass index (BMI) in type 2 diabetes. R-square was 0.074. However, z-score of BMI and total cholesterol level, not HbA1c, had statistical significances in type 1 diabetic patients. R-square was 0.323.
  
  
  CONCLUSIONS
  The increase in the proportions of both type 2 diabetes and MODY in the last 10 years needed to be reminded when diagnosing the subtypes of DM, and the dyslipidemia should be attended more as a common problem of pediatric diabetic patients.
authors.affiliation: Department of Pediatrics, CHA Bundang Medical Center, CHA University, Seongnam, Korea.
authors.forename: Eun Byul
authors.initials: EB
authors.lastname: Kwon
authors.affiliation: Department of Pediatrics, Ajou University Hospital, Ajou University School of Medicine, Suwon, Korea.
authors.forename: Hae Sang
authors.initials: HS
authors.lastname: Lee
authors.affiliation: Department of Pediatrics, Hallym University Medical Center, Hallym University College of Medicine, Seoul, Korea.
authors.forename: Young Seok
authors.initials: YS
authors.lastname: Shim
authors.affiliation: Department of Pediatrics, Masan medical center, Changwon, Korea.
authors.forename: Hwal Rim
authors.initials: HR
authors.lastname: Jeong
authors.affiliation: Department of Pediatrics, Ajou University Hospital, Ajou University School of Medicine, Suwon, Korea.
authors.forename: Jin Soon
authors.initials: JS
authors.lastname: Hwang
keywords: Adolescent; Child; Type 2 diabetes mellitus