title: Pazopanib in Primary Cardiac Angiosarcoma of the Right Atrium: A Case Report.
abstract: Primary heart tumors are an extremely rare oncological entity with primary cardiac sarcomas usually representing 20% of all primary cardiac tumorous lesions [Shanmugam: Eur J Cardiothorac Surg 2006;29: 925-932; Orlandi et al.: J Thorac Oncol 2010;5: 1483-1489]. Angiosarcoma is the most prevalent histology and despite a multidisciplinary approach tends to have a dismal prognosis [Shanmugam: Eur J Cardiothorac Surg 2006;29: 925-932; Fury et al.: Cancer J 2005;11: 241-247]. Based on the prevailing literature, we report a 48-year-old woman diagnosed with primary metastatic cardiac angiosarcoma who showed a severe hypersensitivity reaction to conventional chemotherapy with taxanes but an excellent response to treatment with the multitargeted receptor tyrosine kinase inhibitor pazopanib.
authors.affiliation: Comprehensive Cancer Center - Musculo Skeletal Tumors, GIST, Bone Sarcoma & Soft Tissue Sarcoma Program, Clinical Division of Oncology, Department of Internal Medicine I, Medical University of Vienna, General Hospital Vienna, and Sarcoma Platform Austria, Vienna, Austria.
authors.forename: Sophie
authors.initials: S
authors.lastname: Schur
authors.affiliation: Comprehensive Cancer Center - Musculo Skeletal Tumors, GIST, Bone Sarcoma & Soft Tissue Sarcoma Program, Clinical Division of Oncology, Department of Internal Medicine I, Medical University of Vienna, General Hospital Vienna, and Sarcoma Platform Austria, Vienna, Austria.
authors.forename: Rainer
authors.initials: R
authors.lastname: Hamacher
authors.affiliation: Comprehensive Cancer Center - Musculo Skeletal Tumors, GIST, Bone Sarcoma & Soft Tissue Sarcoma Program, Clinical Division of Oncology, Department of Internal Medicine I, Medical University of Vienna, General Hospital Vienna, and Sarcoma Platform Austria, Vienna, Austria.
authors.forename: Thomas
authors.initials: T
authors.lastname: Brodowicz
keywords: Angiosarcoma; Cardiac sarcoma; Pazopanib; Right atrium; Soft tissue sarcoma