title: Polydatin induces bone marrow stromal cells migration by activation of ERK1/2.
abstract: Bone marrow stromal cells (BMSCs) have proven to be useful for the treatment of numerous human diseases. However, the reparative ability of BMSCs is limited by their poor migration. Polydatin, widely used in traditional Chinese remedies, has proven to exert protective effects to BMSCs. However, little is known about its role in BMSCs migration. In this study, we studied the effects of polydatin on rat BMSCs migration using the scratch wound healing and transwell migration assays. Our results showed polydatin could promote BMSCs migration. Further experiments showed activation of ERK 1/2, but not JNK, was required for polydatin-induced BMSCs migration, suggesting that polydatin may promote BMSCs migration via the ERK 1/2 signaling pathways. Taken together, our results indicate that polydatin might be beneficial for stem cell replacement therapy by improving BMSCs migration.
authors.affiliation: Department of Orthopaedics, The First Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine, Baiyun District, Guangzhou, Guangdong 510405, China; Key Laboratory of Orthopaedics & Traumatology, Guangzhou University of Chinese Medicine, Guangzhou 510405, China.
authors.forename: ZhenQiu
authors.initials: Z
authors.lastname: Chen
authors.affiliation: Department of Orthopaedics, The First Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine, Baiyun District, Guangzhou, Guangdong 510405, China; Key Laboratory of Orthopaedics & Traumatology, Guangzhou University of Chinese Medicine, Guangzhou 510405, China.
authors.forename: QiuShi
authors.initials: Q
authors.lastname: Wei
authors.affiliation: Key Laboratory of Orthopaedics & Traumatology, Guangzhou University of Chinese Medicine, Guangzhou 510405, China.
authors.forename: GuoJu
authors.initials: G
authors.lastname: Hong
authors.affiliation: Key Laboratory of Orthopaedics & Traumatology, Guangzhou University of Chinese Medicine, Guangzhou 510405, China.
authors.forename: Da
authors.initials: D
authors.lastname: Chen
authors.affiliation: Department of Orthopaedics, The First Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine, Baiyun District, Guangzhou, Guangdong 510405, China.
authors.forename: Jiang
authors.initials: J
authors.lastname: Liang
authors.affiliation: Department of Orthopaedics, The First Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine, Baiyun District, Guangzhou, Guangdong 510405, China; Key Laboratory of Orthopaedics & Traumatology, Guangzhou University of Chinese Medicine, Guangzhou 510405, China. Electronic address: hw13802516062@126.com.
authors.forename: Wei
authors.initials: W
authors.lastname: He
authors.affiliation: Key Laboratory of Orthopaedics & Traumatology, Guangzhou University of Chinese Medicine, Guangzhou 510405, China; Guangdong Provincial Acadamy of Chinese Medical Sciences, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou 510120, China. Electronic address: chenmeihuionly@163.com.
authors.forename: Mei Hui
authors.initials: MH
authors.lastname: Chen
mesh_terms: D000818:Animals; D002465:Cell Movement / Q000187:drug effects*; D048430:Cell Shape / Q000187:drug effects; D004789:Enzyme Activation / Q000187:drug effects; D048049:Extracellular Signal-Regulated MAP Kinases / Q000378:metabolism*; D005960:Glucosides / Q000494:pharmacology*; D048031:JNK Mitogen-Activated Protein Kinases / Q000378:metabolism; D008297:Male; D059630:Mesenchymal Stem Cells / Q000166:cytology* / Q000187:drug effects / Q000201:enzymology*; D010766:Phosphorylation / Q000187:drug effects; D017207:Rats, Sprague-Dawley; D013267:Stilbenes / Q000494:pharmacology*
chemical_list: D005960:Glucosides; D013267:Stilbenes; D048049:Extracellular Signal-Regulated MAP Kinases; D048031:JNK Mitogen-Activated Protein Kinases; C058229:polydatin
keywords: BMSCs; ERK 1/2; Migration; Polydatin