title: Two new cyclic bisbibenzyl derivatives from Hebertus dicranus.
abstract: In the present study, two new cyclic bisbibenzyls (1, 2) co-occuring with a known compound, isoplagiochins C (3) were isolated from Hebertus dicranus. The structures were determined mainly by extensive 1D and 2D NMR experiments, and the absolute configurations of 1 and 2 were established by the circular dichroism spectrum. Furthermore, all these three rare compounds were tested in vitro for inhibitory activity against the growth of human cancer cell lines (A549, HCT116, MDA-MB-231, and BEL7404) by the MTT assay, and compound 2 exhibited moderately inhibitory activity with IC50 values ranging from 13.89 to 31.62 μmol·L(-1). In conclusion, our results provided a basis for future development and modification of these compounds for cancer therapy.
authors.affiliation: School of Pharmacy and Life Science, Jiujiang University, Jiujiang 332000, China.
authors.forename: Chang-Long
authors.initials: CL
authors.lastname: Xu
authors.affiliation: School of Pharmacy, Second Military Medical University, Shanghai 200433, China.
authors.forename: Jin-Xin
authors.initials: JX
authors.lastname: Wang
authors.affiliation: School of Pharmacy, Second Military Medical University, Shanghai 200433, China. Electronic address: faranli@hotmail.com.
authors.forename: Hui-Liang
authors.initials: HL
authors.lastname: Li
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000302:isolation & purification; D045744:Cell Line, Tumor; D004365:Drugs, Chinese Herbal / Q000737:chemistry* / Q000302:isolation & purification; D035926:Hepatophyta / Q000737:chemistry*; D006801:Humans; D015394:Molecular Structure
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D004365:Drugs, Chinese Herbal
keywords: (Hebertus dicranus); Circular dichroism spectrum; Cyclic bisbibenzyl