title: Ovarian nongestational choriocarcinoma and associated adenocarcinoma with the same germ cell origin determined by a molecular genetic approach: A case report.
abstract: Ovarian non-gestational choriocarcinomas co-existing with adenocarcinoma are extremely rare and have been reported as epithelial ovarian carcinomas of a "non-germ cell origin" with "choriocarcinomatous differentiation". Although the cellular origin of non-gestational choriocarcinoma may be post-meiotic ovarian germ cells or the dedifferentiation of epithelial ovarian carcinoma, detailed genetic evidence has not yet been obtained to support this. We herein present a case of ovarian non-gestational choriocarcinoma co-existing with adenocarcinoma in a 29-year-old woman. The tumor rapidly increased in size and lung metastases appeared soon after parturition. We genetically demonstrated that the cellular origin of ovarian non-gestational choriocarcinoma was a post-meiotic germ cell derivation using a short tandem repeat analysis. The co-existing adenocarcinoma component was also shown to be of the same germ cell origin. These tumors showed the same homozygous pattern. A molecular genetic approach may be important for understanding the clinicopathological features of such tumors.
authors.affiliation: Department of Obstetrics and Gynecology, School of Medicine, Jichi Medical University, Japan.
authors.forename: Takahiro
authors.initials: T
authors.lastname: Koyanagi
authors.affiliation: Department of Obstetrics and Gynecology, School of Medicine, Jichi Medical University, Japan.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Fujiwara
authors.affiliation: Department of Reproductive Medicine, Graduate School of Medicine, Chiba University, Japan.
authors.forename: Hirokazu
authors.initials: H
authors.lastname: Usui
authors.affiliation: Department of Obstetrics and Gynecology, School of Medicine, Jichi Medical University, Japan.
authors.forename: Haruko
authors.initials: H
authors.lastname: Ariga
authors.affiliation: Department of Obstetrics and Gynecology, School of Medicine, Jichi Medical University, Japan.
authors.forename: Shizuo
authors.initials: S
authors.lastname: Machida
authors.affiliation: Department of Obstetrics and Gynecology, School of Medicine, Jichi Medical University, Japan.
authors.forename: Yuji
authors.initials: Y
authors.lastname: Takei
authors.affiliation: Department of Obstetrics and Gynecology, School of Medicine, Jichi Medical University, Japan.
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Saga
authors.affiliation: Department of Reproductive Medicine, Graduate School of Medicine, Chiba University, Japan.
authors.forename: Makio
authors.initials: M
authors.lastname: Shozu
authors.affiliation: Department of Integrative Pathology, Jichi Medical University, Japan.
authors.forename: Noriyoshi
authors.initials: N
authors.lastname: Fukushima
authors.affiliation: Department of Integrative Pathology, Jichi Medical University, Japan.
authors.forename: Toshiro
authors.initials: T
authors.lastname: Niki
authors.affiliation: Department of Obstetrics and Gynecology, School of Medicine, Jichi Medical University, Japan.
authors.forename: Shigeki
authors.initials: S
authors.lastname: Matsubara
authors.affiliation: Department of Obstetrics and Gynecology, School of Medicine, Jichi Medical University, Japan.
authors.forename: Mitsuaki
authors.initials: M
authors.lastname: Suzuki
mesh_terms: D000230:Adenocarcinoma / Q000235:genetics / Q000473:pathology*; D000328:Adult; D031954:Choriocarcinoma, Non-gestational / Q000235:genetics / Q000473:pathology*; D018240:Endodermal Sinus Tumor / Q000473:pathology; D005260:Female; D006801:Humans; D016609:Neoplasms, Second Primary / Q000473:pathology*; D010051:Ovarian Neoplasms / Q000235:genetics / Q000473:pathology*
keywords: DNA polymorphism analysis; chemotherapy; germ cell origin; non-gestational choriocarcinoma; ovarian cancer