title: Serum paraoxonase 1 activity in patients with iron deficiency anemia.
abstract: BACKGROUND
  In this study we aimed to detect paraoxonase 1 (PON-1) activity in iron deficiency anemia (IDA) and to compare it with healthy controls by observing the change after iron therapy.
  
  
  METHODS
  In this study, 50 adult patients with IDA and 40 healthy subjects were enrolled. All patients were analyzed at the beginning and after treatment according to laboratory assessments.
  
  
  RESULTS
  Mean paraoxonase and arylesterase activities in the iron deficiency anemia group were significantly lower than mean activities of the control group (102.4 ±19.2 U/l and 163.3 ±13.68 U/l, respectively and 157.3 ±26.4 U/l and 256.1 ±24.6 U/l, respectively; p = 0.0001 for both). Paraoxonase and arylesterase activities significantly increased after treatment for IDA (143.2 ±13.9 and 197.6 ±27.9 U/l, respectively, p = 0.0001). Mean activities after treatment with iron were significantly lower than mean activities in the control group (p = 0.002; p = 0.0001 respectively).
  
  
  CONCLUSIONS
  Paraoxonase and arylesterase activities in patients with IDA significantly increased after treatment with iron therapy. In adults IDA may also be one of the factors associated with increased risk of atherosclerosis.
authors.affiliation: Department of Internal Medicine, Bakırkoy Dr. Sadi Konuk Training and Research Hospital, Istanbul, Turkey.
authors.forename: Yildiz
authors.initials: Y
authors.lastname: Okuturlar
authors.affiliation: Department of Biochemistry, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, Istanbul, Turkey.
authors.forename: Asuman
authors.initials: A
authors.lastname: Gedikbasi
authors.affiliation: Department of Nephrology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, Istanbul, Turkey.
authors.forename: Nilgul
authors.initials: N
authors.lastname: Akalin
authors.affiliation: Department of Oncology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, Istanbul, Turkey.
authors.forename: Meral
authors.initials: M
authors.lastname: Gunaldi
authors.affiliation: Department of Internal Medicine, Bakırkoy Dr. Sadi Konuk Training and Research Hospital, Istanbul, Turkey.
authors.forename: Deniz
authors.initials: D
authors.lastname: Yilmaz
authors.affiliation: Department of Endocrinology and Metabolism, Bakırkoy Dr. Sadi Konuk Training and Research Hospital, Istanbul, Turkey.
authors.forename: Meral
authors.initials: M
authors.lastname: Mert
authors.affiliation: Department of Internal Medicine, Bakırkoy Dr. Sadi Konuk Training and Research Hospital, Istanbul, Turkey.
authors.forename: Ozlem
authors.initials: O
authors.lastname: Harmankaya
authors.affiliation: Department of Gastroenterology, Bakırkoy Dr. Sadi Konuk Training and Research Hospital, Istanbul, Turkey.
authors.forename: Aliye
authors.initials: A
authors.lastname: Soylu
authors.affiliation: Department of Endocrinology and Metabolism, Bakırkoy Dr. Sadi Konuk Training and Research Hospital, Istanbul, Turkey.
authors.forename: Pinar
authors.initials: P
authors.lastname: Karakaya
authors.affiliation: Department of Internal Medicine, Bakırkoy Dr. Sadi Konuk Training and Research Hospital, Istanbul, Turkey.
authors.forename: Abdulbaki
authors.initials: A
authors.lastname: Kumbasar
keywords: arylesterase; atherosclerosis; iron deficiency anemia; paraoxonase