title: Clinical and economic burden of bloodstream infections in critical care patients with central venous catheters.
abstract: Bloodstream infections (BSIs) complicate the management of intensive care unit (ICU) patients. We assessed the clinical and economic impact of BSI among patients of a managed care provider group who had a central venous catheter (CVC) placed in the ICU.
  
  
  
  We considered hospitalizations occurring between January 1, 2011, and September 30, 2014, that involved an ICU stay during which a CVC was placed. Comparisons were made between episodes where the patient did vs did not develop BSI after CVC insertion. Length of stay, costs of index hospitalization, and total costs over the 180 days after discharge were compared using linear mixed models. Inhospital mortality and 30-day readmission rates were compared using negative binomial regression models.
  
  
  
  Development of BSI was associated with longer hospital stay (+7 days), more than 3-fold increase in risk of inhospital death, and an additional $129 000 in costs for the index hospitalization. No statistically significant differences in 30-day readmission rates or costs of care over the 180-day period after discharge from the index admission were observed.
  
  
  
  Bloodstream infections after CVC placement in ICU patients are associated with significant increases in costs of care and risk of death during the index hospitalization but no differences in readmissions or costs after discharge.
authors.affiliation: DaVita Clinical Research, Minneapolis, MN, USA. Electronic address: steven.brunelli@davita.com.
authors.forename: Steven M
authors.initials: SM
authors.lastname: Brunelli
authors.affiliation: DaVita Clinical Research, Minneapolis, MN, USA.
authors.forename: Wendy
authors.initials: W
authors.lastname: Turenne
authors.affiliation: DaVita Clinical Research, Minneapolis, MN, USA.
authors.forename: Scott
authors.initials: S
authors.lastname: Sibbel
authors.affiliation: DaVita Clinical Research, Minneapolis, MN, USA.
authors.forename: Abigail
authors.initials: A
authors.lastname: Hunt
authors.affiliation: CorMedix, Inc, Bedminster, NJ, USA.
authors.forename: Antony
authors.initials: A
authors.lastname: Pfaffle
mesh_terms: D000368:Aged; D055499:Catheter-Related Infections / Q000191:economics / Q000453:epidemiology*; D062905:Central Venous Catheters / Q000009:adverse effects*; D003422:Critical Care; D005260:Female; D017048:Health Care Costs / Q000706:statistics & numerical data; D006801:Humans; D007362:Intensive Care Units; D007902:Length of Stay / Q000191:economics / Q000706:statistics & numerical data*; D016014:Linear Models; D008297:Male; D011446:Prospective Studies; D012189:Retrospective Studies; D018805:Sepsis / Q000191:economics / Q000453:epidemiology*; D014481:United States / Q000453:epidemiology
keywords: Bloodstream infection; Central venous catheter; Cost; Intensive care unit; Mortality; Readmission