title: Innate and adaptive immunologic functions of complement in the host response to Listeria monocytogenes infection.
abstract: Listeria monocytogenes is a leading cause of foodborne-illness associated mortality that has attracted considerable attention in recent years due to several significant outbreaks. It has also served as a model organism for the study of intracellular pathogens. For these reasons the host response to L. monocytogenes has long been the subject of investigation. A potent innate and adaptive immune response is required for containment and clearance of L. monocytogenes. However, some elements of this response, such as type 1 interferons, can be detrimental to the host. Recent studies have revealed novel functions for the complement system, an ancient arm of innate immunity, in this process. Here we review the role of complement in the host response to L. monocytogenes.
authors.affiliation: The Brown Foundation Institute of Molecular Medicine, The University of Texas Health Science Center at Houston, Houston, TX 77030, United States; University of Texas McGovern Medical School at Houston, The University of Texas Graduate School of Biomedical Sciences at Houston, Houston, TX 77030, United States.
authors.forename: Daniel G
authors.initials: DG
authors.lastname: Calame
authors.affiliation: The Brown Foundation Institute of Molecular Medicine, The University of Texas Health Science Center at Houston, Houston, TX 77030, United States.
authors.forename: Stacey L
authors.initials: SL
authors.lastname: Mueller-Ortiz
authors.affiliation: The Brown Foundation Institute of Molecular Medicine, The University of Texas Health Science Center at Houston, Houston, TX 77030, United States; Department of Biochemistry and Molecular Biology, University of Texas McGovern Medical School at Houston, Houston, TX 77030, United States. Electronic address: Rick.A.Wetsel@uth.tmc.edu.
authors.forename: Rick A
authors.initials: RA
authors.lastname: Wetsel
mesh_terms: D056704:Adaptive Immunity; D000818:Animals; D003167:Complement Activation; D003165:Complement System Proteins / Q000276:immunology*; D054884:Host-Pathogen Interactions; D006801:Humans; D007113:Immunity, Innate; D007370:Interferon Type I / Q000378:metabolism; D008089:Listeria monocytogenes / Q000276:immunology*; D008088:Listeriosis / Q000276:immunology*
chemical_list: D007370:Interferon Type I; D003165:Complement System Proteins
keywords: Complement; Foodborne illness; Immune response; Listeria monocytogenes