title: Presumed topiramate retinopathy: a case report.
abstract: BACKGROUND
  We report a case of peripheral pigmentary retinopathy and visual field loss following topiramate use for uncontrolled seizures. Such side effects have not been well documented despite the increasing use of topiramate in the past 10 years. A thorough search of available English literature revealed only a small number of reports of topiramate-induced retinopathy or visual field defects in humans. One similar case has been described. We are concerned about the possible rare instances of this occurrence in future patients and hence would like to propose a presumed correlation.
  
  
  METHODS
  A 48-year-old Chinese woman developed blurred vision after 9 months of topiramate use. Her visual acuity dropped from 1.2 to 0.7 in both eyes, with bilateral diffuse pigmentary retinopathy and a constricted visual field. Despite an improvement in visual acuity after cessation of the drug, the other clinical findings remained. The temporal relationship between the initiation of topiramate and the visual disturbance suggests that topiramate could be the cause of such signs and symptoms.
  
  
  CONCLUSIONS
  Topiramate potentially causes pigmentary retinopathy and constricted visual field.
authors.affiliation: Department of Ophthalmology, United Christian Hospital, 130 Hip Wo Street, Kwun Tong, Kowloon, Hong Kong.|Department of Ophthalmology, Tseung Kwan O Hospital, 2 Po Ning Lane, Tseung Kwan O, Hong Kong.|Department of Ophthalmology, LKS Faculty of Medicine, The University of Hong Kong, Pok Fu Lam, Hong Kong.
authors.forename: Tiffany L M
authors.initials: TL
authors.lastname: Yeung
authors.affiliation: Department of Ophthalmology, United Christian Hospital, 130 Hip Wo Street, Kwun Tong, Kowloon, Hong Kong.|Department of Ophthalmology, Tseung Kwan O Hospital, 2 Po Ning Lane, Tseung Kwan O, Hong Kong.|Department of Ophthalmology, LKS Faculty of Medicine, The University of Hong Kong, Pok Fu Lam, Hong Kong.
authors.forename: Patrick S H
authors.initials: PS
authors.lastname: Li
authors.affiliation: Department of Ophthalmology, United Christian Hospital, 130 Hip Wo Street, Kwun Tong, Kowloon, Hong Kong. kennethli@rcsed.ac.uk.|Department of Ophthalmology, Tseung Kwan O Hospital, 2 Po Ning Lane, Tseung Kwan O, Hong Kong. kennethli@rcsed.ac.uk.|Department of Ophthalmology, LKS Faculty of Medicine, The University of Hong Kong, Pok Fu Lam, Hong Kong. kennethli@rcsed.ac.uk.
authors.forename: Kenneth K W
authors.initials: KK
authors.lastname: Li
mesh_terms: D000927:Anticonvulsants / Q000009:adverse effects*; D005260:Female; D005632:Fructose / Q000009:adverse effects / Q000031:analogs & derivatives*; D006801:Humans; D008875:Middle Aged; D012174:Retinitis Pigmentosa / Q000139:chemically induced*; D000077236:Topiramate; D014786:Vision Disorders / Q000139:chemically induced
chemical_list: D000927:Anticonvulsants; D000077236:Topiramate; D005632:Fructose
keywords: Pigmentary retinopathy; Topiramate; Vision disorder; Visual field