title: Harnessing the IL-7/IL-7Rα axis to improve tumor immunotherapy.
abstract: IL-7 and IL-15 are critical for supporting T cells transferred into a lymphopenic environment. As activated CD8(+) T cells downregulate IL-7Rα, it is thought IL-15 is more important. However, we find that CD8(+) T cells activated with IL-12 have elevated IL-7Rα and rely on IL-7 for persistence and antitumor immunity.
authors.affiliation: Department of Surgery, Medical University of South Carolina , Charleston, SC.
authors.forename: C Bryce
authors.initials: CB
authors.lastname: Johnson
authors.affiliation: Department of Microbiology & Immunology, Medical University of South Carolina , Charleston, SC.
authors.forename: John
authors.initials: J
authors.lastname: Wrangle
authors.affiliation: Department of Surgery, Medical University of South Carolina , Charleston, SC.
authors.forename: Shikhar
authors.initials: S
authors.lastname: Mehrotra
authors.affiliation: Department of Microbiology & Immunology, Medical University of South Carolina , Charleston, SC.
authors.forename: Zihai
authors.initials: Z
authors.lastname: Li
authors.affiliation: Department of Surgery, Medical University of South Carolina, Charleston, SC; Department of Microbiology & Immunology, Medical University of South Carolina, Charleston, SC.
authors.forename: Chrystal M
authors.initials: CM
authors.lastname: Paulos
authors.affiliation: Department of Surgery, Medical University of South Carolina , Charleston, SC.
authors.forename: David J
authors.initials: DJ
authors.lastname: Cole
authors.affiliation: Academy of Immunology and Microbiology, Institute for Basic Science, Pohang, South Korea; Department of Integrative Biosciences and Biotechnology, Pohang University of Science and Technology, Pohang, South Korea; Division of Developmental Immunology, La Jolla Institute for Allergy and Immunology, La Jolla, CA, USA.
authors.forename: Charles D
authors.initials: CD
authors.lastname: Surh
authors.affiliation: Department of Surgery, Medical University of South Carolina, Charleston, SC; Department of Microbiology & Immunology, Medical University of South Carolina, Charleston, SC.
authors.forename: Mark P
authors.initials: MP
authors.lastname: Rubinstein
keywords: Adoptive cellular therapy; CD8; IL-15; IL-7; IL-7Ra