title: Organocatalytic Enantioselective Cross-Dehydrogenative Coupling of N-Carbamoyl Cyclic Amines with Aldehydes.
abstract: The existing catalytic enantioselective cross-dehydrogenative coupling of cyclic amines predominantly focused on reactive N-aryl tetrahydroisoquinolines, which typically suffered from limited substrate generality and synthetic utility, and required the use of metal catalyst. Herein, a metal-free catalytic enantioselective cross-dehydrogenative coupling of N-carbamoyl cyclic amines and aldehydes has been reported for the first time. Employing an easily installed and functionalized acyl protecting group rather than the widely adopted aryl moiety endows the enantioselective process with better substrate generality and broader synthetic utility.
authors.affiliation: School of Pharmaceutical Sciences, Shandong University , Jinan 250012, China.
authors.forename: Zhiyu
authors.initials: Z
authors.lastname: Xie
authors.affiliation: School of Pharmaceutical Sciences, Shandong University , Jinan 250012, China.|Department of Pharmacy, Xi'an Central Hospital , Xi'an 710003, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Zan
authors.affiliation: School of Pharmaceutical Sciences, Shandong University , Jinan 250012, China.
authors.forename: Shutao
authors.initials: S
authors.lastname: Sun
authors.affiliation: School of Pharmaceutical Sciences, Shandong University , Jinan 250012, China.
authors.forename: Xinhui
authors.initials: X
authors.lastname: Pan
authors.affiliation: School of Pharmaceutical Sciences, Shandong University , Jinan 250012, China.|School of Chemistry and Chemical Engineering, Shandong University , Jinan 250100, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Liu