title: "Smart" nickel oxide based core-shell nanoparticles for combined chemo and photodynamic cancer therapy.
abstract: We report "smart" nickel oxide nanoparticles (NOPs) as multimodal cancer therapy agent. Water-dispersible and light-sensitive NiO core was synthesized with folic acid (FA) connected bovine serum albumin (BSA) shell on entrapped doxorubicin (DOX). The entrapped drug from NOP-DOX@BSA-FA was released in a sustained way (64 hours, pH=5.5, dark conditions) while a robust release was found under red light exposure (in 1/2 hour under λmax=655 nm, 50 mW/cm(2), at pH=5.5). The cell viability, thiobarbituric acid reactive substances and diphenylisobenzofuran assays conducted under light and dark conditions revealed a high photodynamic therapy potential of our construct. Furthermore, we found that the combined effect of DOX and NOPs from NOP-DOX@BSA-FA resulted in cell death approximately eightfold high compared to free DOX. We propose that NOP-DOX@BSA-FA is a potential photodynamic therapy agent and a collective drug delivery system for the systemic administration of cancer chemotherapeutics resulting in combination therapy.
authors.affiliation: Department of Physics, The Islamia University of Bahawalpur; Nanosciences and Technology Department, National Centre for Physics, Islamabad; Institute of Biomedical and Genetic Engineering, Islamabad, Pakistan.
authors.forename: Shazia
authors.initials: S
authors.lastname: Bano
authors.affiliation: Nanosciences and Technology Department, National Centre for Physics, Islamabad.
authors.forename: Samina
authors.initials: S
authors.lastname: Nazir
authors.affiliation: Institute of Biomedical and Genetic Engineering, Islamabad, Pakistan.
authors.forename: Saeeda
authors.initials: S
authors.lastname: Munir
authors.affiliation: College of Pharmacy, King Saud University, Riyadh, Kingdom of Saudi Arabia.
authors.forename: Mohamed Fahad
authors.initials: MF
authors.lastname: AlAjmi
authors.affiliation: Department of Physics, The Islamia University of Bahawalpur.
authors.forename: Muhammad
authors.initials: M
authors.lastname: Afzal
authors.affiliation: Institute of Biomedical and Genetic Engineering, Islamabad, Pakistan.
authors.forename: Kehkashan
authors.initials: K
authors.lastname: Mazhar
mesh_terms: D000970:Antineoplastic Agents / Q000494:pharmacology / Q000627:therapeutic use*; D016923:Cell Death / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D004317:Doxorubicin / Q000494:pharmacology / Q000627:therapeutic use; D016503:Drug Delivery Systems; D065546:Drug Liberation; D005492:Folic Acid / Q000494:pharmacology / Q000627:therapeutic use; D006367:HeLa Cells; D006801:Humans; D008856:Microscopy, Fluorescence; D053758:Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D054118:Nanospheres / Q000648:ultrastructure; D009369:Neoplasms / Q000188:drug therapy*; D009532:Nickel / Q000737:chemistry*; D010778:Photochemotherapy / Q000379:methods*; D017382:Reactive Oxygen Species / Q000378:metabolism; D012710:Serum Albumin, Bovine / Q000737:chemistry
chemical_list: D000970:Antineoplastic Agents; D017382:Reactive Oxygen Species; D012710:Serum Albumin, Bovine; D009532:Nickel; D004317:Doxorubicin; D005492:Folic Acid; C028007:nickel monoxide
keywords: bovine serum albumin; cancer; light-triggered drug release; multi-model therapy