title: TSOC-HFrEF Registry: A Registry of Hospitalized Patients with Decompensated Systolic Heart Failure: Description of Population and Management.
abstract: BACKGROUND
  Heart failure (HF) is a medical condition with a rapidly increasing incidence both in Taiwan and worldwide. The objective of the TSOC-HFrEF registry was to assess epidemiology, etiology, clinical management, and outcomes in a large sample of hospitalized patients presenting with acute decompensated systolic HF.
  
  
  METHODS
  The TSOC-HFrEF registry was a prospective, multicenter, observational survey of patients presenting to 21 medical centers or teaching hospitals in Taiwan. Hospitalized patients with either acute new-onset HF or acute decompensation of chronic HFrEF were enrolled. Data including demographic characteristics, medical history, primary etiology of HF, precipitating factors for HF hospitalization, presenting symptoms and signs, diagnostic and treatment procedures, in-hospital mortality, length of stay, and discharge medications, were collected and analyzed.
  
  
  RESULTS
  A total of 1509 patients were enrolled into the registry by the end of October 2014, with a mean age of 64 years (72% were male). Ischemic cardiomyopathy and dilated cardiomyopathy were diagnosed in 44% and 33% of patients, respectively. Coronary artery disease, hypertension, diabetes, and chronic renal insufficiency were the common comorbid conditions. Acute coronary syndrome, non-compliant to treatment, and concurrent infection were the major precipitating factors for acute decompensation. The median length of hospital stay was 8 days, and the in-hospital mortality rate was 2.4%. At discharge, 62% of patients were prescribed either angiotensin-converting enzyme-inhibitors or angiotensin receptor blockers, 60% were prescribed beta-blockers, and 49% were prescribed mineralocorticoid receptor antagonists.
  
  
  CONCLUSIONS
  The TSOC-HFrEF registry provided important insights into the current clinical characteristics and management of hospitalized decompensated systolic HF patients in Taiwan. One important observation was that adherence to guideline-directed medical therapy was suboptimal.
authors.affiliation: Division of Cardiology, Chang Gung Memorial Hospital, Linkou;
authors.forename: Chun-Chieh
authors.initials: CC
authors.lastname: Wang
authors.affiliation: Heart Center, Cheng Hsin General Hospital, Taipei;
authors.forename: Hung-Yu
authors.initials: HY
authors.lastname: Chang
authors.affiliation: Heart Center, Cheng Hsin General Hospital, Taipei;
authors.forename: Wei-Hsian
authors.initials: WH
authors.lastname: Yin
authors.affiliation: Cardiology Division of Cardiovascular Medical Center, Far Eastern memorial Hospital, New Taipei City;
authors.forename: Yen-Wen
authors.initials: YW
authors.lastname: Wu
authors.affiliation: Division of Cardiology, Chang Gung Memorial Hospital, Linkou;
authors.forename: Pao-Hsien
authors.initials: PH
authors.lastname: Chu
authors.affiliation: Cardiovascular Center, National Taiwan University Hospital, Hsinchu Branch, Hsinchu;
authors.forename: Chih-Cheng
authors.initials: CC
authors.lastname: Wu
authors.affiliation: Institute of Clinical Medicine, National Cheng Kung University, College of Medicine, and National Cheng Kung University Hospital, Tainan;
authors.forename: Chih-Hsin
authors.initials: CH
authors.lastname: Hsu
authors.affiliation: Division of Cardiology, Chang Gung Memorial Hospital, Linkou;
authors.forename: Ming-Shien
authors.initials: MS
authors.lastname: Wen
authors.affiliation: Division of Cardiology, Department of Internal Medicine, Kaohsiung Medical University Chung-Ho Memorial Hospital, Kaohsiung;
authors.forename: Wen-Chol
authors.initials: WC
authors.lastname: Voon
authors.affiliation: Division of Cardiology, Department of Internal Medicine, Tri-Service General Hospital and National Defense Medical Center, Taipei;
authors.forename: Wei-Shiang
authors.initials: WS
authors.lastname: Lin
authors.affiliation: Cardiovascular Center, Taichung Veterans General Hospital, Taichung;
authors.forename: Jin-Long
authors.initials: JL
authors.lastname: Huang
authors.affiliation: Section of Cardiology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung;
authors.forename: Shyh-Ming
authors.initials: SM
authors.lastname: Chen
authors.affiliation: Division of Cardiology, Department of Internal Medicine, Chang Gung Memorial Hospital, Keelung;
authors.forename: Ning-I
authors.initials: NI
authors.lastname: Yang
authors.affiliation: Division of Cardiology, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei City;
authors.forename: Heng-Chia
authors.initials: HC
authors.lastname: Chang
authors.affiliation: Division of Cardiovascular Medicine and Cardiovascular Research Laboratory, China Medical University Hospital, Taichung;
authors.forename: Kuan-Cheng
authors.initials: KC
authors.lastname: Chang
authors.affiliation: Division of Cardiology, Taipei Veterans General Hospital;
authors.forename: Shih-Hsien
authors.initials: SH
authors.lastname: Sung
authors.affiliation: Division of Cardiology, Shin Kong Wu Ho-Su Memorial Hospital;
authors.forename: Kou-Gi
authors.initials: KG
authors.lastname: Shyu
authors.affiliation: Division of Cardiology, Department of Internal Medicine, National Taiwan University Hospital, Taipei;
authors.forename: Jiunn-Lee
authors.initials: JL
authors.lastname: Lin
authors.affiliation: Division of Cardiology, Kaohsiung Veterans General Hospital, Kaohsiung;
authors.forename: Guang-Yuan
authors.initials: GY
authors.lastname: Mar
authors.affiliation: Department of Internal Medicine, Chung-Shan Medical University Hospital, Taichung;
authors.forename: Kuei-Chuan
authors.initials: KC
authors.lastname: Chan
authors.affiliation: Division of Cardiology, Department of Internal Medicine, MacKay Memorial Hospital, Taipei;
authors.forename: Jen-Yuan
authors.initials: JY
authors.lastname: Kuo
authors.affiliation: Division of Cardiology, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien;
authors.forename: Ji-Hung
authors.initials: JH
authors.lastname: Wang
authors.affiliation: Division of Cardiovascular Medicine, Chimei Medical Center, Tainan;
authors.forename: Zhih-Cherng
authors.initials: ZC
authors.lastname: Chen
authors.affiliation: Division of Cardiology, Department of Internal Medicine, E-Da Hospital, Kaohsiung, Taiwan.
authors.forename: Wei-Kung
authors.initials: WK
authors.lastname: Tseng
authors.affiliation: Division of Cardiology, Department of Internal Medicine, Chang Gung Memorial Hospital, Keelung;
authors.forename: Wen-Jin
authors.initials: WJ
authors.lastname: Cherng
keywords: Beta-blocker; Guideline; Heart failure; Renin-angiotensin system blocker; Taiwan; Treatment