title: The role low microRNA-335 expression in prognosis prediction of human cancers.
abstract: BACKGROUND
  MicroRNA-335 (miR-335) serves as one of the known miRs in human cancers, however, its prognostic role has yet been settled down. The present research is formed to discuss whether or not miR-335 could be identified as a prognostic biomarker of human cancers.
  
  
  METHODS
  All eligible references from four main databases were included in this study based on the inclusion/exclusion criteria. Moreover, we performed a meta-analysis to explore the prognostic role of miR-335 in human cancers.
  
  
  RESULTS
  Finally, we found eight articles which met the inclusion/exclusion criteria, involving 1098 subjects. miR-335 is deregulated in human cancer tissues compared to noncancerous tissues. We found that the pooled hazard ratios with 95% confidence interval were 1.35 (1.00, 1.83) for overall survival and 1.54 (0.36, 6.68) for relapse-free survival.
  
  
  CONCLUSIONS
  The prognostic value of the low miR-335 expression cannot be completely decided based on the present evidences. More related clinical research should be implemented to further study the prognostic role of miR-335 in human cancers.
authors.affiliation: Department of Gynaecology and Obstetrics, Renmin Hospital of Wuhan University, Wuhan 430060, Hubei Province, P.R. China.
authors.forename: Du
authors.initials: D
authors.lastname: He
authors.affiliation: Department of Gynaecology and Obstetrics, Renmin Hospital of Wuhan University, Wuhan 430060, Hubei Province, P.R. China.
authors.forename: Li
authors.initials: L
authors.lastname: Hong
authors.affiliation: Department of Gynaecology and Obstetrics, Renmin Hospital of Wuhan University, Wuhan 430060, Hubei Province, P.R. China.
authors.forename: Wenjun
authors.initials: W
authors.lastname: Guo
mesh_terms: D014408:Biomarkers, Tumor; D005500:Follow-Up Studies; D015870:Gene Expression; D006801:Humans; D035683:MicroRNAs / Q000235:genetics*; D009369:Neoplasms / Q000175:diagnosis / Q000235:genetics* / Q000401:mortality*; D011379:Prognosis; D016016:Proportional Hazards Models; D017594:Publication Bias
chemical_list: D014408:Biomarkers, Tumor; C556347:MIRN335 microRNA, human; D035683:MicroRNAs