title: Serum paraoxonase activity and oxidative stress levels in patients with cutaneous anthrax.
abstract: BACKGROUND
  Anthrax is a bacterial disease caused by the aerobic sporeforming bacterium Bacillus anthracis. It has been suggested that oxidative stress plays an important role in the pathogenesis of B. anthracis. The aim of this study was to investigate serum paraoxonase 1 (PON1) activity, catalase activity, malondialdehyde (MDA) levels, and superoxide dismutase (SOD) levels in patients with cutaneous anthrax.
  
  
  METHODS
  Fifteen patients with cutaneous anthrax and 15 healthy controls were enrolled in this study. The serum MDA levels, SOD levels, paraoxonase, arylesterase, and catalase activities were measured using a spectrophotometer.
  
  
  RESULTS
  The serum SOD levels, paraoxonase, arylesterase, and catalase activities were significantly lower in patients with cutaneous anthrax than in controls (for all, p < 0.001), whereas MDA levels were significantly higher ( p < 0.001). No significant correlation was found between serum paraoxonase activity, arylesterase activity, SOD levels, and MDA levels (all, p > 0.05) in patients with cutaneous anthrax.
  
  
  CONCLUSIONS
  The current study was the first to show decreased antioxidant levels and increased oxidant levels in patients with cutaneous anthrax. Therefore, decreased PON1 activity may play a role in the pathogenesis of cutaneous anthrax.
authors.affiliation: 1 Department of Emergency Medicine, Faculty of Medical, Yuzuncu Yıl University, Van, Turkey.
authors.forename: S
authors.initials: S
authors.lastname: Karadas
authors.affiliation: 2 Department of Internal Medicine, Faculty of Medical, Yuzuncu Yıl University, Van, Turkey.
authors.forename: M
authors.initials: M
authors.lastname: Aslan
authors.affiliation: 3 Department of Infectious Disease and Clinical Microbiology, Faculty of Medical, Yuzuncu Yıl University, Van, Turkey.
authors.forename: M R
authors.initials: MR
authors.lastname: Ceylan
authors.affiliation: 3 Department of Infectious Disease and Clinical Microbiology, Faculty of Medical, Yuzuncu Yıl University, Van, Turkey.
authors.forename: M
authors.initials: M
authors.lastname: Sunnetcioglu
authors.affiliation: 4 Department of Otorhinolaryngology, Faculty of Medical, Yuzuncu Yıl University, Van, Turkey.
authors.forename: N
authors.initials: N
authors.lastname: Bozan
authors.affiliation: 1 Department of Emergency Medicine, Faculty of Medical, Yuzuncu Yıl University, Van, Turkey.
authors.forename: H
authors.initials: H
authors.lastname: Kara
authors.affiliation: 5 Department of Chemistry, Faculty of Science and Art, Yuzuncu Yıl University, Van, Turkey.
authors.forename: H
authors.initials: H
authors.lastname: Demir
mesh_terms: D000328:Adult; D000881:Anthrax / Q000097:blood*; D043303:Aryldialkylphosphatase / Q000097:blood*; D002265:Carboxylic Ester Hydrolases / Q000097:blood; D002374:Catalase / Q000097:blood; D002784:Cholesterol / Q000097:blood; D005260:Female; D006801:Humans; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D008875:Middle Aged; D018384:Oxidative Stress; D017192:Skin Diseases, Bacterial / Q000097:blood*; D013482:Superoxide Dismutase / Q000097:blood; D014280:Triglycerides / Q000097:blood
chemical_list: D014280:Triglycerides; D008315:Malondialdehyde; D002784:Cholesterol; D002374:Catalase; D013482:Superoxide Dismutase; D002265:Carboxylic Ester Hydrolases; C019734:arylesterase; D043303:Aryldialkylphosphatase; C468406:PON1 protein, human
keywords: Cutaneous anthrax; PON1 activity; catalase activity; malondialdehyde; superoxide dismutase