title: Filling the (SR)GAP in Excitatory/Inhibitory Balance.
abstract: In this issue of Neuron, Fossati et al. (2016) report that through its domain structure, SRGAP2A, a Rho-GTPase-activating protein, can co-regulate excitatory and inhibitory synapse development, offering a putative evolutionary genetic mechanism for preserving excitatory/inhibitory balance during speciation.
authors.affiliation: Picower Institute for Learning and Memory, Departments of Biology and Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
authors.forename: Jaichandar
authors.initials: J
authors.lastname: Subramanian
authors.affiliation: Picower Institute for Learning and Memory, Departments of Biology and Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. Electronic address: nedivi@mit.edu.
authors.forename: Elly
authors.initials: E
authors.lastname: Nedivi
mesh_terms: D000818:Animals; D020690:GTPase-Activating Proteins / Q000235:genetics* / Q000378:metabolism; D006801:Humans; D009154:Mutation / Q000235:genetics; D009474:Neurons / Q000378:metabolism*; D013569:Synapses / Q000502:physiology*
chemical_list: D020690:GTPase-Activating Proteins; C465659:SRGAP3 protein, human; C085379:rho GTPase-activating protein