title: Autologous Unpurged Bone Marrow Transplantation for Acute Non Lymphoblastic Leukemia in First Remission.
abstract: Forty consecutive adult patients under the age of 50 with acute non-lymphoblastic leukemia (ANLL) in first complete remission, underwent autologous bone marrow transplantation (ABMT) between March 1984 and April 1990. The conditioning regimen employed included cyclophosphamide and total body irradiation, followed by the administration of unpurged ABMT. The median time from diagnosis to transplant was 7 months (3-15 months), and the median time from complete remission to ABMT was 4 months (range 3-9 months). Twenty-two (51%) patients remain in complete remission 6-81 months (median 24 months) after ABMT. The causes of death were, recurrent leukemia (11 patients), parenchymal toxicities such as acute respiratory distress syndrome and veno-occlusive disease (3 patients), hemorrhage (2 patients) and infection (2 patients). Eleven patients relapsed after 3-12 months (median 5 months). This study has produced survival data comparable to those of other institutions employing TBI for either allo or autotransplants.
authors.affiliation: a Oncohematologic and ABMT Section, Division of Hematology II, S. Maztino's Hospital, Genoa, Italy.
authors.forename: A M
authors.initials: AM
authors.lastname: Carella
authors.affiliation: a Oncohematologic and ABMT Section, Division of Hematology II, S. Maztino's Hospital, Genoa, Italy.
authors.forename: S
authors.initials: S
authors.lastname: Nati
authors.affiliation: a Oncohematologic and ABMT Section, Division of Hematology II, S. Maztino's Hospital, Genoa, Italy.
authors.forename: P
authors.initials: P
authors.lastname: Carlier
authors.affiliation: a Oncohematologic and ABMT Section, Division of Hematology II, S. Maztino's Hospital, Genoa, Italy.
authors.forename: D
authors.initials: D
authors.lastname: Pierluigi
authors.affiliation: b Division of Hematology I, University of Genoa, Genoa, Italy.
authors.forename: D
authors.initials: D
authors.lastname: Giordano
authors.affiliation: b Division of Hematology I, University of Genoa, Genoa, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Congiu
authors.affiliation: b Division of Hematology I, University of Genoa, Genoa, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Santini
authors.affiliation: c Institute of Radiology, University of Genoa, Genoa, Italy.
authors.forename: D
authors.initials: D
authors.lastname: Scarpati
authors.affiliation: d National Institute for Cancer Research, Genoa, Italy.
authors.forename: S
authors.initials: S
authors.lastname: Barra
authors.affiliation: d National Institute for Cancer Research, Genoa, Italy.
authors.forename: R
authors.initials: R
authors.lastname: Corvo
authors.affiliation: d National Institute for Cancer Research, Genoa, Italy.
authors.forename: V
authors.initials: V
authors.lastname: Vitale
authors.affiliation: b Division of Hematology I, University of Genoa, Genoa, Italy.
authors.forename: M R
authors.initials: MR
authors.lastname: Raffo
authors.affiliation: b Division of Hematology I, University of Genoa, Genoa, Italy.
authors.forename: R
authors.initials: R
authors.lastname: Cerri
authors.affiliation: b Division of Hematology I, University of Genoa, Genoa, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Risso
authors.affiliation: b Division of Hematology I, University of Genoa, Genoa, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Spriano
authors.affiliation: b Division of Hematology I, University of Genoa, Genoa, Italy.
authors.forename: R
authors.initials: R
authors.lastname: Vimercati
authors.affiliation: b Division of Hematology I, University of Genoa, Genoa, Italy.
authors.forename: E
authors.initials: E
authors.lastname: Pungolino
authors.affiliation: a Oncohematologic and ABMT Section, Division of Hematology II, S. Maztino's Hospital, Genoa, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Bacigalupo
authors.affiliation: b Division of Hematology I, University of Genoa, Genoa, Italy.
authors.forename: E
authors.initials: E
authors.lastname: Damasio
keywords: ANLL; Autologous BMT