title: Consumption of pomegranate juice decreases blood lipid peroxidation and levels of arachidonic acid in women with metabolic syndrome.
abstract: BACKGROUND
  Pomegranate juice is a rich source of polyphenols and is thus a promising dietary antioxidant with numerous health-promoting effects. These include a beneficial impact on cardiovascular health that could be partly attributed to the effects of polyphenols on lipid metabolism. The aim of this study was to investigate whether consumption of pomegranate juice for 6 weeks could modify lipid peroxidation and phospholipid fatty acid composition of plasma and erythrocytes in subjects with metabolic syndrome. Twenty-three women, aged 40-60 years, were enrolled and randomly assigned into two groups: the intervention group, in which each participant consumed 300 mL of juice per day for 6 weeks; and a control group.
  
  
  RESULTS
  A statistically significant decrease in the relative amount of arachidonic acid (P < 0.05) and an increase in the relative amount of saturated fatty acids (P < 0.05) were observed in the intervention group at the end of the consumption period. In addition, pomegranate juice significantly increased the relative amount of total mono-unsaturated fatty acids (P < 0.05), and significantly decreased the levels of thiobarbituric acid reactive substances in erythrocytes (P < 0.05). The status of blood lipids and the values for blood pressure were not changed during the study.
  
  
  CONCLUSIONS
  The results obtained indicate a positive impact of the consumption of pomegranate juice on lipid peroxidation and fatty acid status in subjects with metabolic syndrome and suggest potential anti-inflammatory and cardio-protective effects. © 2016 Society of Chemical Industry.
authors.affiliation: Centre of Research Excellence in Nutrition and Metabolism, Institute for Medical Research, University of Belgrade, Tadeusa Koscuska 1, 11129, Belgrade, Serbia.
authors.forename: Milica I
authors.initials: MI
authors.lastname: Kojadinovic
authors.affiliation: Centre of Research Excellence in Nutrition and Metabolism, Institute for Medical Research, University of Belgrade, Tadeusa Koscuska 1, 11129, Belgrade, Serbia.
authors.forename: Aleksandra C
authors.initials: AC
authors.lastname: Arsic
authors.affiliation: Centre of Research Excellence in Nutrition and Metabolism, Institute for Medical Research, University of Belgrade, Tadeusa Koscuska 1, 11129, Belgrade, Serbia.
authors.forename: Jasmina D
authors.initials: JD
authors.lastname: Debeljak-Martacic
authors.affiliation: Centre of Research Excellence in Nutrition and Metabolism, Institute for Medical Research, University of Belgrade, Tadeusa Koscuska 1, 11129, Belgrade, Serbia.
authors.forename: Aleksandra I
authors.initials: AI
authors.lastname: Konic-Ristic
authors.affiliation: Centre of Research Excellence in Nutrition and Metabolism, Institute for Medical Research, University of Belgrade, Tadeusa Koscuska 1, 11129, Belgrade, Serbia.
authors.forename: Nevena Dj
authors.initials: ND
authors.lastname: Kardum
authors.affiliation: Centre of Research Excellence in Nutrition and Metabolism, Institute for Medical Research, University of Belgrade, Tadeusa Koscuska 1, 11129, Belgrade, Serbia.
authors.forename: Tamara B
authors.initials: TB
authors.lastname: Popovic
authors.affiliation: Centre of Research Excellence in Nutrition and Metabolism, Institute for Medical Research, University of Belgrade, Tadeusa Koscuska 1, 11129, Belgrade, Serbia.
authors.forename: Marija D
authors.initials: MD
authors.lastname: Glibetic
mesh_terms: D000328:Adult; D016718:Arachidonic Acid / Q000097:blood*; D005260:Female; D005638:Fruit / Q000737:chemistry / Q000378:metabolism; D000067030:Fruit and Vegetable Juices / Q000032:analysis*; D006801:Humans; D015227:Lipid Peroxidation; D008055:Lipids / Q000097:blood*; D029561:Lythraceae / Q000737:chemistry / Q000378:metabolism*; D024821:Metabolic Syndrome / Q000097:blood / Q000178:diet therapy*; D008875:Middle Aged
chemical_list: D008055:Lipids; D016718:Arachidonic Acid
keywords: arachidonic acid; fatty acid; lipid peroxidation; metabolic syndrome; pomegranate juice