title: Hypo-high-density Lipoprotein Cholesterolemia Caused by Evacuation after the Fukushima Daiichi Nuclear Power Plant Accident: Results from the Fukushima Health Management Survey.
abstract: Objective The Great East Japan Earthquake and the Fukushima Daiichi nuclear disaster forced the evacuation of residents and led to many changes in the lifestyle of the evacuees. A comprehensive health check was implemented to support the prevention of lifestyle-related disease, and we analyzed changes in lipid metabolism before and after these disasters. Methods Subjects included Japanese men and women living near the Fukushima Daiichi nuclear power plant in Fukushima Prefecture. Annual health checkups, focusing on metabolic syndromes, were conducted for persons ≥40 years of age by the Heath Care Insures. Results A total of 27,486 subjects underwent a follow-up examination after the disaster, with a mean follow-up of 1.6 years. Following the disaster, the prevalence of hypo-high-density lipoprotein (HDL) cholesterolemia increased significantly from 6.0% to 7.2%. In the hypo-HDL cholesterolemia group, the body mass index (BMI), blood pressure, and LDL-C level increased significantly in men after the disaster. On the other hand, in the normal HDL-C level group, the BMI, blood pressure, glucose and lipid metabolism, and liver function were adversely affected. The decrease in HDL-C was significantly greater in evacuees than non-evacuees in the normal HDL-C level group. Furthermore, a multivariate logistic regression analysis showed that the evacuation was significantly associated with the incidence of hypo-HDL cholesterolemia. Conclusion This is the first study to evaluate how the evacuation affected the incidence of hypo-HDL cholesterolemia and led to an increase in cardiovascular disease. This information may be important in the follow-up and lifestyle change recommendations for evacuees.
authors.affiliation: Department of Nephrology, Hypertension, Diabetology, Endocrinology, and Metabolism, Fukushima Medical University, Japan.
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Satoh
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Ohira
authors.forename: Masato
authors.initials: M
authors.lastname: Nagai
authors.forename: Mitsuaki
authors.initials: M
authors.lastname: Hosoya
authors.forename: Akira
authors.initials: A
authors.lastname: Sakai
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Watanabe
authors.forename: Akira
authors.initials: A
authors.lastname: Ohtsuru
authors.forename: Yukihiko
authors.initials: Y
authors.lastname: Kawasaki
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Suzuki
authors.forename: Atsushi
authors.initials: A
authors.lastname: Takahashi
authors.forename: Gen
authors.initials: G
authors.lastname: Kobashi
authors.forename: Kotaro
authors.initials: K
authors.lastname: Ozasa
authors.forename: Seiji
authors.initials: S
authors.lastname: Yasumura
authors.forename: Shunichi
authors.initials: S
authors.lastname: Yamashita
authors.forename: Kenji
authors.initials: K
authors.lastname: Kamiya
authors.forename: Masafumi
authors.initials: M
authors.lastname: Abe
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001786:Blood Glucose; D001794:Blood Pressure; D015992:Body Mass Index; D005260:Female; D062406:Fukushima Nuclear Accident; D006306:Health Surveys / Q000706:statistics & numerical data*; D006801:Humans; D007009:Hypolipoproteinemias / Q000453:epidemiology*; D015994:Incidence; D007564:Japan / Q000453:epidemiology; D008019:Life Style; D008055:Lipids / Q000097:blood; D008075:Lipoproteins, HDL / Q000097:blood*; D008111:Liver Function Tests; D008297:Male; D024821:Metabolic Syndrome / Q000453:epidemiology*; D008875:Middle Aged; D015995:Prevalence
chemical_list: D001786:Blood Glucose; D008055:Lipids; D008075:Lipoproteins, HDL