title: Hydrogen sulfide-releasing anti-inflammatory drugs for chemoprevention and treatment of cancer.
abstract: For many years it has been recognized that inhibition of cyclooxygenase enzymes is effective in reducing the incidence of many types of cancer, but the adverse effects of these drug, particularly in the gastrointestinal and cardiovascular systems, limits their utility. Recently developed hydrogen sulfide-releasing anti-inflammatory drugs may be a promising option for cancer chemoprevention. In this paper we review evidence suggesting that these novel compounds are effective in a range of animal models of various types of cancer, while exhibiting greatly reduced toxicity relative to currently marketed non-steroidal anti-inflammatory drugs. Some of the possible mechanisms of action of hydrogen sulfide-releasing anti-inflammatory drugs are also discussed.
authors.affiliation: Department of Pharmacy, University of Naples Federico II, Naples, Italy.
authors.forename: Angela
authors.initials: A
authors.lastname: Ianaro
authors.affiliation: Department of Pharmacy, University of Naples Federico II, Naples, Italy; Faculty of Medicine, Universidade Camilo Castelo Branco, São Paulo, SP, Brazil.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Cirino
authors.affiliation: Faculty of Medicine, Universidade Camilo Castelo Branco, São Paulo, SP, Brazil; Department of Physiology & Pharmacology, University of Calgary, Calgary, AB, Canada. Electronic address: wallacej@ucalgary.ca.
authors.forename: John L
authors.initials: JL
authors.lastname: Wallace
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*; D016588:Anticarcinogenic Agents / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*; D018890:Chemoprevention; D006801:Humans; D006862:Hydrogen Sulfide / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*; D007414:Intestinal Neoplasms / Q000188:drug therapy / Q000517:prevention & control; D008545:Melanoma / Q000517:prevention & control
chemical_list: D000893:Anti-Inflammatory Agents; D016588:Anticarcinogenic Agents; D006862:Hydrogen Sulfide
keywords: Chemoprevention; Colon cancer; Hydrogen sulfide; Inflammation; Melanoma; Transcriptomics