title: Concurrent Chemotherapy of Malignant Glioma in Rats by Using Multidrug-Loaded Biodegradable Nanofibrous Membranes.
abstract: Glioblastoma multiforme has a poor prognosis and is highly chemoresistant. In this study, we implanted biodegradable 1,3-bis[2-chloroethyl]-1-nitroso-urea-, irinotecan-, and cisplatin-eluting poly[(d,l)-lactide-co-glycolide] (BIC/PLGA) and virgin nanofibrous membranes on the brain surface of C6 glioma-bearing rats in concurrent and virgin groups, respectively. The concentrations of all applied drugs were significantly higher in the brain than in the blood for more than 8 weeks in all studied rats. Tumor growth was more rapid in the vehicle-treated group, and tumor volumes were significantly higher in the vehicle-treated group. Moreover, the average survival time was significantly shorter in the vehicle-treated group (P = 0.026), and the BIC/PLGA nanofibrous membranes significantly reduced the risk of mortality (P < 0.001). Furthermore, the results suggested that the BIC/PLGA nanofibers reduced the malignancy of C6 glioma. The experimental findings indicate that the multianticancer drug (i.e., BIC)-eluting PLGA nanofibers are favorable candidates for treating malignant glioma.
authors.affiliation: Department of Neurosurgery, Shuang Ho Hospital, Taipei Medical University, Taipei, Taiwan.|Department of Surgery, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.
authors.forename: Yuan-Yun
authors.initials: YY
authors.lastname: Tseng
authors.affiliation: Department of Neurosurgery, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Tao-Yuan, Taiwan.
authors.forename: Yin-Chen
authors.initials: YC
authors.lastname: Huang
authors.affiliation: Department of Neurosurgery, Taichung Tzu Chi General Hospital, The Buddhist Tzu Chi Medical Foundation, Taichung, Taiwan.
authors.forename: Tao-Chieh
authors.initials: TC
authors.lastname: Yang
authors.affiliation: Department of Neurosurgery, Shuang Ho Hospital, Taipei Medical University, Taipei, Taiwan.|Department of Surgery, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.
authors.forename: Shun-Tai
authors.initials: ST
authors.lastname: Yang
authors.affiliation: Department of Mechanical Engineering, Chang Gung University, Tao-Yuan, Taiwan.
authors.forename: Shou-Cheng
authors.initials: SC
authors.lastname: Liu
authors.affiliation: Department of Mechanical Engineering, Chang Gung University, Tao-Yuan, Taiwan.
authors.forename: Tzu-Min
authors.initials: TM
authors.lastname: Chang
authors.affiliation: Department of Anesthesiology, Chang Gung Memorial Hospital, Tao-Yuan, Taiwan.
authors.forename: Yi-Chuan
authors.initials: YC
authors.lastname: Kau
authors.affiliation: Department of Mechanical Engineering, Chang Gung University, Tao-Yuan, Taiwan.|Department of Orthopedics, Chang Gung Memorial Hospital, Tao-Yuan, Taiwan.
authors.forename: Shih-Jung
authors.initials: SJ
authors.lastname: Liu
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000493:pharmacokinetics; D001774:Blood Chemical Analysis; D001923:Brain Chemistry; D001932:Brain Neoplasms / Q000188:drug therapy* / Q000473:pathology; D004195:Disease Models, Animal; D004337:Drug Carriers / Q000008:administration & dosage*; D004358:Drug Therapy / Q000379:methods*; D005909:Glioblastoma / Q000188:drug therapy* / Q000473:pathology; D049329:Nanostructures / Q000008:administration & dosage*; D051381:Rats; D016896:Treatment Outcome
chemical_list: D000970:Antineoplastic Agents; D004337:Drug Carriers