title: Inhibition of IL-6 trans-signaling in the brain increases sociability in the BTBR mouse model of autism.
abstract: Autism is a severe neurodevelopmental disorder with a large population prevalence, characterized by abnormal reciprocal social interactions, communication deficits, and repetitive behaviors with restricted interests. The BTBR T(+)Itpr3(tf) (BTBR) mice have emerged as strong candidates to serve as models of a range of autism-relevant behaviors. Increasing evidences suggest that interleukin (IL)-6, one of the most important neuroimmune factors, was involved in the pathophysiology of autism. It is of great importance to further investigate whether therapeutic interventions in autism can be achieved through the manipulation of IL-6. Our previous studies showed that IL-6 elevation in the brain could mediate autistic-like behaviors, possibly through the imbalances of neural circuitry and impairments of synaptic plasticity. In this study, we evaluate whether inhibiting IL-6 signaling in the brain is sufficient to modulate the autism-like behaviors on the BTBR mice. The results showed that chronic infusion of an analog of the endogenous IL-6 trans-signaling blocker sgp130Fc protein increased the sociability in BTBR mice. Furthermore, no change was observed in the number of excitatory synapse, level of synaptic proteins, density of dentitic spine and postsynaptic density in BTBR cortices after inhibiting IL-6 trans-signaling. However, inhibition of IL-6 trans-signaling increased the evoked glutamate release in synaptoneurosomes from the cerebral cortex of BTBR mice. Our findings suggest that inhibition of excessive production of IL-6 may have selective therapeutic efficacy in treating abnormal social behaviors in autism.
authors.affiliation: Department of Rehabilitation Medicine, Shanxi Provincial People's Hospital, Affiliate of Shanxi Medical University, Taiyuan, China. Electronic address: hongenwei@gmail.com.
authors.forename: Hongen
authors.initials: H
authors.lastname: Wei
authors.affiliation: Central Laboratory, Shanxi Provincial People's Hospital, Affiliate of Shanxi Medical University, Taiyuan, China.
authors.forename: Yuehong
authors.initials: Y
authors.lastname: Ma
authors.affiliation: Central Laboratory, Shanxi Provincial People's Hospital, Affiliate of Shanxi Medical University, Taiyuan, China.
authors.forename: Jianrong
authors.initials: J
authors.lastname: Liu
authors.affiliation: Central Laboratory, Shanxi Provincial People's Hospital, Affiliate of Shanxi Medical University, Taiyuan, China.
authors.forename: Caiyun
authors.initials: C
authors.lastname: Ding
authors.affiliation: Central Laboratory, Shanxi Provincial People's Hospital, Affiliate of Shanxi Medical University, Taiyuan, China.
authors.forename: Guorong
authors.initials: G
authors.lastname: Jin
authors.affiliation: Central Laboratory, Shanxi Provincial People's Hospital, Affiliate of Shanxi Medical University, Taiyuan, China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Neurology, Shanxi Provincial People's Hospital, Affiliate of Shanxi Medical University, Taiyuan, China.
authors.forename: Fengyun
authors.initials: F
authors.lastname: Hu
authors.affiliation: Department of Rehabilitation Medicine, Shanxi Provincial People's Hospital, Affiliate of Shanxi Medical University, Taiyuan, China.
authors.forename: Li
authors.initials: L
authors.lastname: Yu
mesh_terms: D000818:Animals; D001321:Autistic Disorder / Q000188:drug therapy / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D001522:Behavior, Animal; D002540:Cerebral Cortex / Q000378:metabolism* / Q000473:pathology; D050822:Cytokine Receptor gp130 / Q000627:therapeutic use; D004195:Disease Models, Animal; D006801:Humans; D007141:Immunoglobulin Fc Fragments / Q000494:pharmacology; D015850:Interleukin-6 / Q000235:genetics / Q000378:metabolism*; D051379:Mice; D008822:Mice, Transgenic; D009473:Neuronal Plasticity; D057907:Post-Synaptic Density / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D011994:Recombinant Proteins / Q000494:pharmacology; D015398:Signal Transduction; D000093242:Interleukin-6 Inhibitors
chemical_list: D050822:Cytokine Receptor gp130; D007141:Immunoglobulin Fc Fragments; D015850:Interleukin-6; D011994:Recombinant Proteins; D000093242:Interleukin-6 Inhibitors; C494200:Il6st protein, mouse; C577686:interleukin-6, mouse
keywords: Autism; BTBR; Glutamate release; IL-6; Sociability