title: Process Development for Separation of Conformers from Derivatives of Resorcin[4]arenes and Pyrogallol[4]arenes.
abstract: Macrocyclic compounds, such as resorcin[4]arenes and pyrogallol[4]arenes, have proven to be useful building blocks in the construction of supramolecular organic frameworks (SOFs) because of their unique bowl-like shape and ability to interact through variety of intermolecular interactions. Herein, we report the synthesis and crystal structures of two functionalized resorcin[4]arenes and pyroagllol[4]arenes, 4-hydroxyphenylresorcin[4]arenes, and 4-hydroxyphenylpyrogallol[4]arenes. These phenyl-functionalized macrocycles usually have different conformers, such as cone, boat, chair, saddle, and diamond. The successful separation of predominant conformers from the crude product was carried out with solvent-extraction technique. The shape and molecular arrangement of these conformers in the individual crystal structure was verified with single-crystal X-ray diffraction studies.
authors.affiliation: Department of Chemistry, University of Missouri-Columbia, 601 S College Ave, Columbia, MO, 65211, USA.
authors.forename: Rahul S
authors.initials: RS
authors.lastname: Patil
authors.affiliation: Department of Chemistry, University of Missouri-Columbia, 601 S College Ave, Columbia, MO, 65211, USA.
authors.forename: Chen
authors.identifier: http://orcid.org/0000-0001-5552-1960
authors.initials: C
authors.lastname: Zhang
authors.affiliation: Department of Chemistry, University of Missouri-Columbia, 601 S College Ave, Columbia, MO, 65211, USA. AtwoodJ@missouri.edu.
authors.forename: Jerry L
authors.initials: JL
authors.lastname: Atwood
keywords: isomeric conformers; macrocycles; molecular building blocks; solvent extractions; supramolecular organic frameworks