title: Should I Stay or Should I Go?
abstract: In this issue of Neuron, Lee et al. (2016) assessed the brain-wide effects of stimulating the direct and indirect pathway by optogenetic activation of D1 and D2 striatal neurons. This work demonstrates the exquisite power of combining cell-type-specific perturbation methods with focal and whole-brain measurements of brain activity.
authors.affiliation: Laboratory of Neuro-and Psychophysiology, Department of Neurosciences, KU Leuven Medical School, 3000 Leuven, Belgium; Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA 02129, USA; Department of Radiology, Harvard Medical School, Boston, MA 02114, USA. Electronic address: wim@nmr.mgh.harvard.edu.
authors.forename: Wim
authors.initials: W
authors.lastname: Vanduffel
authors.affiliation: Laboratory of Neuro-and Psychophysiology, Department of Neurosciences, KU Leuven Medical School, 3000 Leuven, Belgium; Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA 02129, USA.
authors.forename: John T
authors.initials: JT
authors.lastname: Arsenault
mesh_terms: D000818:Animals; D003342:Corpus Striatum / Q000187:drug effects* / Q000378:metabolism; D004298:Dopamine / Q000378:metabolism*; D018492:Dopamine Antagonists / Q000494:pharmacology*; D006801:Humans; D009474:Neurons / Q000187:drug effects* / Q000502:physiology; D017447:Receptors, Dopamine D1 / Q000378:metabolism*; D017448:Receptors, Dopamine D2 / Q000378:metabolism*
chemical_list: D018492:Dopamine Antagonists; D017447:Receptors, Dopamine D1; D017448:Receptors, Dopamine D2; D004298:Dopamine