title: Primary Orbital Histiocytic Sarcoma in a Child Successfully Treated With Multiagent Chemotherapy.
abstract: Histiocytic sarcoma (HS), a malignant proliferation of mature tissue histiocytes presenting with single or multifocal extranodal tumors, is rarely seen in children. Primary orbital HS has never been reported in a child. Disseminated disease to the bone marrow typically has an aggressive course and poor prognosis. There is no consensus currently on the optimal therapeutic approach for HS. We present the case of a 2-year-old girl with orbital HS with likely bone marrow involvement treated successfully with multiagent chemotherapy, now in complete remission and disease free 3.5 years from end of therapy.
authors.affiliation: Departments of *Pediatrics, Division of Pediatric Hematology Oncology §Ophthalmology and Visual Sciences ∥Pathology ¶Radiology, University of Illinois at Chicago †Department of Pediatrics, Division of Pediatric Hematology Oncology, Rush University Medical Center ‡Department of Pediatrics, Division of Pediatric Hematology Oncology, John. H. Stroger hospital, Chicago, IL.
authors.forename: Nupur
authors.initials: N
authors.lastname: Mittal
authors.forename: Vinay
authors.initials: V
authors.lastname: Aakalu
authors.forename: Sangeeta
authors.initials: S
authors.lastname: Mehendele
authors.forename: Pete
authors.initials: P
authors.lastname: Setabutr
authors.forename: Edward
authors.initials: E
authors.lastname: Michals
authors.forename: Mary L
authors.initials: ML
authors.lastname: Schmidt
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002675:Child, Preschool; D005260:Female; D054747:Histiocytic Sarcoma / Q000175:diagnosis / Q000188:drug therapy* / Q000473:pathology; D006801:Humans; D008279:Magnetic Resonance Imaging; D009918:Orbital Neoplasms / Q000175:diagnosis / Q000188:drug therapy* / Q000473:pathology; D016896:Treatment Outcome