title: Molecularly Imprinted Intelligent Scaffolds for Tissue Engineering Applications.
abstract: The development of molecularly imprinted polymers (MIPs) using biocompatible production methods enables the possibility to further exploit this technology for biomedical applications. Tissue engineering (TE) approaches use the knowledge of the wound healing process to design scaffolds capable of modulating cell behavior and promote tissue regeneration. Biomacromolecules bear great interest for TE, together with the established recognition of the extracellular matrix, as an important source of signals to cells, both promoting cell-cell and cell-matrix interactions during the healing process. This review focuses on exploring the potential of protein molecular imprinting to create bioactive scaffolds with molecular recognition for TE applications based on the most recent approaches in the field of molecular imprinting of macromolecules. Considerations regarding essential components of molecular imprinting technology will be addressed for TE purposes. Molecular imprinting of biocompatible hydrogels, namely based on natural polymers, is also reviewed here. Hydrogel scaffolds with molecular memory show great promise for regenerative therapies. The first molecular imprinting studies analyzing cell adhesion report promising results with potential applications for cell culture systems, or biomaterials for implantation with the capability for cell recruitment by selectively adsorbing desired molecules.
authors.affiliation: 1 Instituto de Investigação e Inovação em Saúde (i3S), Universidade do Porto , Porto, Portugal .|2 Instituto de Ciências Biomédicas Abel Salazar (ICBAS), Universidade do Porto , Porto, Portugal .|3 Faculdade de Engenharia da Universidade do Porto (FEUP) , Porto, Portugal .
authors.forename: Mariana I
authors.initials: MI
authors.lastname: Neves
authors.affiliation: 4 Department of Biomedical Engineering, The University of Texas at Austin , Austin, Texas.|5 Institute of Biomaterials, Drug Delivery and Regenerative Medicine, The University of Texas at Austin , Austin, Texas.
authors.forename: Marissa E
authors.initials: ME
authors.lastname: Wechsler
authors.affiliation: 6 3B's Research Group, Universidade do Minho , Guimarães, Portugal .
authors.forename: Manuela E
authors.initials: ME
authors.lastname: Gomes
authors.affiliation: 6 3B's Research Group, Universidade do Minho , Guimarães, Portugal .
authors.forename: Rui L
authors.initials: RL
authors.lastname: Reis
authors.affiliation: 1 Instituto de Investigação e Inovação em Saúde (i3S), Universidade do Porto , Porto, Portugal .|2 Instituto de Ciências Biomédicas Abel Salazar (ICBAS), Universidade do Porto , Porto, Portugal .|3 Faculdade de Engenharia da Universidade do Porto (FEUP) , Porto, Portugal .|7 Instituto de Engenharia Biomédica (INEB), Universidade do Porto , Porto, Portugal .
authors.forename: Pedro L
authors.initials: PL
authors.lastname: Granja
authors.affiliation: 4 Department of Biomedical Engineering, The University of Texas at Austin , Austin, Texas.|5 Institute of Biomaterials, Drug Delivery and Regenerative Medicine, The University of Texas at Austin , Austin, Texas.|8 McKetta Department of Chemical Engineering, The University of Texas at Austin , Austin, Texas.|9 Department of Surgery and Perioperative Care, Dell Medical School, The University of Texas at Austin , Austin, Texas.|10 Division of Pharmaceutics, College of Pharmacy, The University of Texas at Austin , Austin, Texas.
authors.forename: Nicholas A
authors.initials: NA
authors.lastname: Peppas
mesh_terms: D001672:Biocompatible Materials; D020100:Hydrogels; D054802:Molecular Imprinting; D011108:Polymers; D023822:Tissue Engineering
chemical_list: D001672:Biocompatible Materials; D020100:Hydrogels; D011108:Polymers
keywords: intelligent polymers; molecular imprinting; tissue engineering