title: Neural correlates of motor recovery after robot-assisted stroke rehabilitation: a case series study.
abstract: Robot-assisted bilateral arm therapy (RBAT) has shown promising results in stroke rehabilitation; however, connectivity mapping of the sensorimotor networks after RBAT remains unclear. We used fMRI before and after RBAT and a dose-matched control intervention (DMCI) to explore the connectivity changes in 6 subacute stroke patients. Sensorimotor functions improved in the RBAT and DMCI groups after treatment. Enhanced activation changes were observed in bilateral primary motor cortex (M1) and bilateral supplementary motor area (SMA) after RBAT. Dynamic causal model analysis revealed that interhemispheric connections were enhanced in RBAT patients. These preliminary findings suggest that intracortical and intercortical coupling might underlie poststroke RBAT.
authors.affiliation: a School of Occupational Therapy, College of Medicine , National Taiwan University , Taipei , Taiwan.
authors.forename: Yang-Teng
authors.initials: YT
authors.lastname: Fan
authors.affiliation: a School of Occupational Therapy, College of Medicine , National Taiwan University , Taipei , Taiwan.|b Division of Occupational Therapy, Department of Physical Medicine and Rehabilitation , National Taiwan University Hospital , Taipei , Taiwan.
authors.forename: Keh-Chung
authors.initials: KC
authors.lastname: Lin
authors.affiliation: c Department of Medical Imaging and Radiological Sciences , Chang Gung University , Taoyuan , Taiwan.|d Department of Imaging Physics, Division of Diagnostic Imaging , The University of Texas MD Anderson Cancer Center , Houston , TX , USA.
authors.forename: Ho-Ling
authors.initials: HL
authors.lastname: Liu
authors.affiliation: e Department of Occupational Therapy and Graduate Institute of Behavioral Sciences, College of Medicine , Chang Gung University , Taoyuan , Taiwan.|f Healthy Aging Research Center , Chang Gung University , Taoyuan , Taiwan.
authors.forename: Ching-Yi
authors.initials: CY
authors.lastname: Wu
authors.affiliation: g Department of Diagnostic Radiology , Chang Gung Memorial Hospital , Keelung , Taiwan.|h MRI Center , Chang Gung Memorial Hospital , Taoyuan , Taiwan.
authors.forename: Yau-Yau
authors.initials: YY
authors.lastname: Wai
authors.affiliation: i Department of Neurology and Stroke Center , Chang Gung Memorial Hospital , Taoyuan , Taiwan.
authors.forename: Tsong-Hai
authors.initials: TH
authors.lastname: Lee
mesh_terms: D000328:Adult; D001931:Brain Mapping; D007839:Functional Laterality / Q000502:physiology; D006225:Hand / Q000503:physiopathology; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D008959:Models, Neurological; D009068:Movement / Q000502:physiology*; D009434:Neural Pathways / Q000000981:diagnostic imaging / Q000502:physiology; D011597:Psychomotor Performance / Q000502:physiology; D020127:Recovery of Function / Q000502:physiology*; D012371:Robotics / Q000379:methods*; D020521:Stroke / Q000503:physiopathology*; D000071939:Stroke Rehabilitation
keywords: Bilateral arm training; dynamic causal model (DCM); neuroplasticity; robot; stroke