title: Xerostomia, Hyposalivation, and Salivary Flow in Diabetes Patients.
abstract: The presence of xerostomia and hyposalivation is frequent among diabetes mellitus (DM) patients. It is not clear if the presence of xerostomia and hyposalivation is greater in DM than non-DM patients. The aims of this systematic review are (1) to compare the prevalence rates of xerostomia, (2) to evaluate the salivary flow rate, and (3) to compare the prevalence rates of hyposalivation in DM versus non-DM population. This systematic review was conducted according to the PRISMA group guidelines by performing systematic literature searches in biomedical databases from 1970 until January 18th, 2016. All studies showed higher prevalence of xerostomia in DM patients in relation to non-DM population, 12.5%-53.5% versus 0-30%. Studies that analyzed the quantity of saliva in DM population in relation to non-DM patients reported higher flow rates in non-DM than in DM patients. The variation flow rate among different studies in each group (DM/CG) is very large. Only one existing study showed higher hyposalivation prevalence in DM than non-DM patients (45% versus 2.5%). In addition, quality assessment showed the low quality of the existing studies. We recommend new studies that use more precise and current definitions concerning the determination and diagnosis of DM patients and salivary flow collection.
authors.affiliation: Department of Oral Medicine and Surgery, School of Dentistry, Complutense University, 28040 Madrid, Spain.
authors.forename: Rosa María
authors.identifier: 0000-0002-5727-0920
authors.initials: RM
authors.lastname: López-Pintor
authors.affiliation: Department of Oral Medicine and Surgery, School of Dentistry, Complutense University, 28040 Madrid, Spain.
authors.forename: Elisabeth
authors.initials: E
authors.lastname: Casañas
authors.affiliation: Department of Oral Medicine and Surgery, School of Dentistry, Complutense University, 28040 Madrid, Spain.
authors.forename: José
authors.identifier: 0000-0003-1060-5305
authors.initials: J
authors.lastname: González-Serrano
authors.affiliation: Department of Oral Medicine and Surgery, School of Dentistry, Complutense University, 28040 Madrid, Spain.
authors.forename: Julia
authors.identifier: 0000-0002-4460-3183
authors.initials: J
authors.lastname: Serrano
authors.affiliation: Department of Oral Medicine and Surgery, School of Dentistry, Complutense University, 28040 Madrid, Spain.
authors.forename: Lucía
authors.initials: L
authors.lastname: Ramírez
authors.affiliation: Department of Oral Medicine and Surgery, School of Dentistry, Complutense University, 28040 Madrid, Spain.
authors.forename: Lorenzo
authors.initials: L
authors.lastname: de Arriba
authors.affiliation: Department of Oral Medicine and Surgery, School of Dentistry, Complutense University, 28040 Madrid, Spain.
authors.forename: Gonzalo
authors.initials: G
authors.lastname: Hernández
mesh_terms: D048909:Diabetes Complications / Q000453:epidemiology* / Q000503:physiopathology; D003920:Diabetes Mellitus / Q000453:epidemiology*; D006801:Humans; D012463:Saliva / Q000378:metabolism; D012469:Salivary Glands / Q000378:metabolism; D014987:Xerostomia / Q000453:epidemiology* / Q000503:physiopathology