title: Short sleep duration is associated with increased risk of pre-hypertension and hypertension in Chinese early middle-aged females.
abstract: OBJECTIVE
  The aim of this study is to investigate the relationship between sleep duration and hypertension in a middle-aged Chinese population.
  
  
  METHODS
  Cross-sectional data of 20,505 individuals aged 35-64 years from Taizhou longitudinal study was used. Logistic regression models were used to calculate odds ratios (ORs) for the risk of pre-hypertension and hypertension in association with sleep duration.
  
  
  RESULTS
  Short sleep duration was associated with high systolic and diastolic blood pressure in comparison with sleep duration of 7-8 h in females. Short sleep duration was also associated with an increased risk of hypertension in females. Age-stratified analysis showed that as compared with sleep duration of 7-8 h, sleep duration <6 h increased risk of hypertension after controlling for multiple covariates with an OR of 1.766 (1.024-2.775) in early middle-aged females of 35-44 years. More importantly, sleeping less than 6 h is associated with increased risk of pre-hypertension in females of this age category, after controlling for multiple covariates with an OR of 1.769 (1.058-2.958).
  
  
  CONCLUSIONS
  Sleeping less than 6 h a day is associated with increased risk of pre-hypertension and hypertension in Chinese early middle-aged females. The high-risk populations require sufficient sleep, which could probably prevent the increased risk of pre-hypertension as well as hypertension.
authors.affiliation: Unit of Epidemiology, State Key Laboratory of Genetic Engineering and MOE Key Laboratory of Contemporary Anthropology, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University, 220 Handan Rd, Shanghai, 200433, China.
authors.forename: Xun-Ming
authors.initials: XM
authors.lastname: Sun
authors.affiliation: Unit of Epidemiology, State Key Laboratory of Genetic Engineering and MOE Key Laboratory of Contemporary Anthropology, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University, 220 Handan Rd, Shanghai, 200433, China.
authors.forename: Shun
authors.initials: S
authors.lastname: Yao
authors.affiliation: Unit of Epidemiology, State Key Laboratory of Genetic Engineering and MOE Key Laboratory of Contemporary Anthropology, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University, 220 Handan Rd, Shanghai, 200433, China.
authors.forename: Shu-Juan
authors.initials: SJ
authors.lastname: Hu
authors.affiliation: Unit of Epidemiology, State Key Laboratory of Genetic Engineering and MOE Key Laboratory of Contemporary Anthropology, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University, 220 Handan Rd, Shanghai, 200433, China.
authors.forename: Zu-Yun
authors.initials: ZY
authors.lastname: Liu
authors.affiliation: Taizhou Research Institute of Health Sciences, Taizhou, Jiangsu, 225312, China.
authors.forename: Ya-Jun
authors.initials: YJ
authors.lastname: Yang
authors.affiliation: Taizhou Research Institute of Health Sciences, Taizhou, Jiangsu, 225312, China.
authors.forename: Zi-Yu
authors.initials: ZY
authors.lastname: Yuan
authors.affiliation: Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
authors.forename: Wei-Min
authors.initials: WM
authors.lastname: Ye
authors.affiliation: Unit of Epidemiology, State Key Laboratory of Genetic Engineering and MOE Key Laboratory of Contemporary Anthropology, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University, 220 Handan Rd, Shanghai, 200433, China.
authors.forename: Li
authors.initials: L
authors.lastname: Jin
authors.affiliation: Unit of Epidemiology, State Key Laboratory of Genetic Engineering and MOE Key Laboratory of Contemporary Anthropology, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University, 220 Handan Rd, Shanghai, 200433, China. xiaofengwang71@163.com.
authors.forename: Xiao-Feng
authors.initials: XF
authors.lastname: Wang
mesh_terms: D000328:Adult; D002681:China; D005260:Female; D006801:Humans; D006973:Hypertension / Q000453:epidemiology* / Q000209:etiology*; D008875:Middle Aged; D058246:Prehypertension / Q000453:epidemiology* / Q000209:etiology*; D018570:Risk Assessment / Q000706:statistics & numerical data; D012893:Sleep Wake Disorders / Q000150:complications* / Q000453:epidemiology*; D013223:Statistics as Topic
keywords: Female; Hypertension; Middle-aged population; Pre-hypertension; Sleep duration