title: Phonoarticulation in spinocerebellar ataxia type 3.
abstract: Phonoarticulation is characterized by changes in resonance, diadochokinesis, prosody, sound frequency, vocal quality, and intraoral pressure. The main aim of this study was to characterize the phonoarticulation in spinocerebellar ataxia type 3 (SCA3) and correlate it with clinical and genetic factors. Thirty-one patients with SCA3 who were subjected to spontaneous speech recordings and phonoarticulatory diadochokinesis (DDK) participated in the study. Speech analyses were performed starting after 10 s of spontaneous speech, by three experienced speech therapists, using a protocol for dysarthria adapted from the Mayo Clinic. The intra-evaluator reliability was analyzed. The lower the patient's age at disease onset was, the more frequent the occurrences of monofrequency and altered speech rhythm were. Articulation, DDK, resonance, and prosody showed a moderate correlation with the number of "CAG" triplet repeats. We conclude that the phonoarticulation of patients with Machado-Joseph disease (MJD) is characterized by mixed dysarthrophonia with cerebellar and hypokinetic components, and that there is a tendency toward higher frequency of dysarthrophonia symptoms with lower age of disease onset, longer time since onset and higher number of "CAG" triplet repeats.
authors.affiliation: School of Medicine Ribeirão Preto, USP Ribeirão Preto, Ribeirão Preto, Brazil.
authors.forename: A E
authors.initials: AE
authors.lastname: Wolf
authors.affiliation: Unicamp Medicine School, Universidade Estadual de Campinas, Rua Tessália Vieira de Camargo, 126. Cidade Universitária Zeferino Vaz, 13083-887, Campinas, São Paulo, Brazil.
authors.forename: L
authors.initials: L
authors.lastname: Mourão
authors.affiliation: Unicamp Medicine School, Universidade Estadual de Campinas, Rua Tessália Vieira de Camargo, 126. Cidade Universitária Zeferino Vaz, 13083-887, Campinas, São Paulo, Brazil.
authors.forename: M C
authors.initials: MC
authors.lastname: França
authors.affiliation: Unicamp Medicine School, Universidade Estadual de Campinas, Rua Tessália Vieira de Camargo, 126. Cidade Universitária Zeferino Vaz, 13083-887, Campinas, São Paulo, Brazil. almiromachadophd@gmail.com.
authors.forename: A J
authors.initials: AJ
authors.lastname: Machado Júnior
authors.affiliation: Unicamp Medicine School, Universidade Estadual de Campinas, Rua Tessália Vieira de Camargo, 126. Cidade Universitária Zeferino Vaz, 13083-887, Campinas, São Paulo, Brazil.
authors.forename: A N
authors.initials: AN
authors.lastname: Crespo
mesh_terms: D000293:Adolescent; D000328:Adult; D017668:Age of Onset; D000368:Aged; D004401:Dysarthria / Q000175:diagnosis / Q000209:etiology* / Q000235:genetics; D005260:Female; D006801:Humans; D017827:Machado-Joseph Disease / Q000150:complications* / Q000235:genetics; D008297:Male; D008875:Middle Aged; D015588:Observer Variation; D015203:Reproducibility of Results; D013062:Speech Articulation Tests; D066229:Speech Sound Disorder / Q000175:diagnosis / Q000209:etiology* / Q000235:genetics; D018911:Trinucleotide Repeats; D055815:Young Adult
keywords: Dysarthria; Machado–Joseph disease; Speech; Spinocerebellar ataxia; Voice