title: Primary Noncutaneous Malignant Melanoma of the Breast.
abstract: Primary noncutaneous breast melanoma without an apparent skin primary lesion is uncommon. Its pathogenesis is debated with some authors believing that it is a metastatic disease from an undiscovered primary or a primary that has since completely regressed but it may be a true primary tumor arising from ectopic melanocytes. We present a case of a V600E BRAF mutation-positive primary noncutaneous breast melanoma diagnosed at an early stage in a screening mammogram as a solitary breast lesion without nodal involvement. Considerations of treatment of this rare disease are discussed.
authors.affiliation: Division of Medical Oncology, Department of Internal Medicine, Sault Area Hospital, Sault Ste Marie, Ontario, Canada.
authors.forename: Mohammad
authors.initials: M
authors.lastname: Rassouli
authors.affiliation: Division of Medical Oncology, Department of Internal Medicine, Sault Area Hospital, Sault Ste Marie, Ontario, Canada.|Division of Clinical Sciences, Northern Ontario School of Medicine, Sudbury, Ontario, Canada.
authors.forename: Ioannis A
authors.initials: IA
authors.lastname: Voutsadakis
mesh_terms: D001943:Breast Neoplasms / Q000000981:diagnostic imaging* / Q000235:genetics / Q000473:pathology* / Q000628:therapy; D005260:Female; D006801:Humans; D008327:Mammography; D008545:Melanoma / Q000000981:diagnostic imaging* / Q000235:genetics / Q000473:pathology* / Q000628:therapy; D008875:Middle Aged; D009154:Mutation; D048493:Proto-Oncogene Proteins B-raf / Q000235:genetics; D012878:Skin Neoplasms / Q000473:pathology
chemical_list: C482119:BRAF protein, human; D048493:Proto-Oncogene Proteins B-raf
keywords: 
  BRAF
  ; breast; malignant melanoma; noncutaneous; parenchymal; primary