title: Impact of the Recent Mouse P-Glycoprotein Structure for Structure-Based Ligand Design.
abstract: P-Glycoprotein (P-gp), a transmembrane, ATP-dependent drug efflux transporter, has attracted considerable interest both with respect to its role in tumour cell multidrug resistance and in absorption-distribution and elimination of drugs. Although known since more than 30 years, the understanding of the molecular basis of drug/transporter interaction is still limited, which is mainly due to the lack of structural information available. However, within the past decade X-ray structures of several bacterial homologues as well as very recently also of mouse P-gp have become available. Within this review we give an overview on the current status of structural information available and on its impact for structure-based drug design.
authors.affiliation: University of Vienna, Department of Medicinal Chemistry, Althanstraße 14, 1090 Wien, Austria phone: +43-1-4277-55110; fax: +43-1-4277-9551.
authors.forename: Freya
authors.initials: F
authors.lastname: Klepsch
authors.affiliation: University of Vienna, Department of Medicinal Chemistry, Althanstraße 14, 1090 Wien, Austria phone: +43-1-4277-55110; fax: +43-1-4277-9551. Gerhard.f.ecker@univie.ac.at.
authors.forename: Gerhard F
authors.initials: GF
authors.lastname: Ecker
keywords: Drug design, Ligands; Molecular modelling; Proteins