title: Regulation of centriolar satellite integrity and its physiology.
abstract: Centriolar satellites comprise cytoplasmic granules that are located around the centrosome. Their molecular identification was first reported more than a quarter of a century ago. These particles are not static in the cell but instead constantly move around the centrosome. Over the last decade, significant advances in their molecular compositions and biological functions have been achieved due to comprehensive proteomics and genomics, super-resolution microscopy analyses and elegant genetic manipulations. Centriolar satellites play pivotal roles in centrosome assembly and primary cilium formation through the delivery of centriolar/centrosomal components from the cytoplasm to the centrosome. Their importance is further underscored by the fact that mutations in genes encoding satellite components and regulators lead to various human disorders such as ciliopathies. Moreover, the most recent findings highlight dynamic structural remodelling in response to internal and external cues and unexpected positive feedback control that is exerted from the centrosome for centriolar satellite integrity.
authors.affiliation: Lincoln's Inn Fields Laboratory, The Francis Crick Institute, 44 Lincoln's Inn Fields, London, WC2A 3LY, UK.|Developmental Biomedical Science, Graduate School of Biological Sciences, Nara Institute of Science and Technology (NAIST), 8916-5 Takayama, Ikoma, Nara, 630-0192, Japan.
authors.forename: Akiko
authors.initials: A
authors.lastname: Hori
authors.affiliation: Lincoln's Inn Fields Laboratory, The Francis Crick Institute, 44 Lincoln's Inn Fields, London, WC2A 3LY, UK. takashi-toda@hiroshima-u.ac.jp.|Department of Molecular Biotechnology, Hiroshima Research Center for Healthy Aging (HiHA), Graduate School of Advanced Sciences of Matter, Hiroshima University, 1-3-1 Kagamiyama, Higashi-Hiroshima, 739-8530, Japan. takashi-toda@hiroshima-u.ac.jp.
authors.forename: Takashi
authors.identifier: 0000-0001-7851-1757
authors.initials: T
authors.lastname: Toda
mesh_terms: D000818:Animals; D002453:Cell Cycle; D002502:Centrioles / Q000502:physiology*; D002923:Cilia / Q000378:metabolism; D003594:Cytoplasmic Granules / Q000502:physiology*; D006801:Humans; D008870:Microtubules / Q000378:metabolism; D013312:Stress, Physiological
keywords: Cellular stress; Centriole; Ciliogenesis; MSD1/SSX2IP; Microtubule; PCM1; PLK4; Phosphorylation; Ubiquitylation