title: Synchronous Upper and Lower Gastrointestinal Mucosa-Associated Lymphoid Tissue Lymphomas.
abstract: Mucosa-associated lymphoid tissue lymphoma (MALToma) is a subtype of B-cell non-Hodgkin's lymphoma, comprising ∼17% of all gastrointestinal (GI) tract lymphomas. It is associated with chronic inflammation and autoimmunity, for example Helicobacter pylori gastritis and Sjogren's syndrome, respectively. Approximately 50% of GI MALTomas occur in the stomach, with small bowel and colonic lesions being less frequent. Synchronous upper and lower GI MALTomas occur rarely, with few cases reported. We present the case of a 73-year-old patient who presented with change in bowel habit and was found to have synchronous multifocal upper and lower GI MALTomas, which did not respond to H. pylori cure or to rituximab therapy, but did respond to a combination of surgery and chemotherapy with rituximab and bendamustine.
authors.affiliation: Department of Gastroenterology, UHCW, Coventry, United Kingdom.
authors.forename: Michael
authors.initials: M
authors.lastname: McFarlane
authors.affiliation: Department of Gastroenterology, UHCW, Coventry, United Kingdom.
authors.forename: John Lin Hieng
authors.initials: JL
authors.lastname: Wong
authors.affiliation: Department of Haematology, Heart of England NHS Trust, Birmingham, United Kingdom.
authors.forename: Shankara
authors.initials: S
authors.lastname: Paneesha
authors.affiliation: Department of Histopathology, Heart of England NHS Trust, Birmingham, United Kingdom.
authors.forename: Zbigniew
authors.initials: Z
authors.lastname: Rudzki
authors.affiliation: Department of Gastroenterology, UHCW, Coventry, United Kingdom.
authors.forename: Ramesh
authors.initials: R
authors.lastname: Arasaradnam
authors.affiliation: Department of Gastroenterology, UHCW, Coventry, United Kingdom.
authors.forename: Chuka
authors.initials: C
authors.lastname: Nwokolo
keywords: Gastrointestinal; Lower; MALToma; Synchronous; Upper