title: Quercetin reduces manic-like behavior and brain oxidative stress induced by paradoxical sleep deprivation in mice.
abstract: Quercetin is a known antioxidant and protein kinase C (PKC) inhibitor. Previous studies have shown that mania involves oxidative stress and an increase in PKC activity. We hypothesized that quercetin affects manic symptoms. In the present study, manic-like behavior (hyperlocomotion) and oxidative stress were induced by 24h paradoxical sleep deprivation (PSD) in male Swiss mice. Both 10 and 40mg/kg quercetin prevented PSD-induced hyperlocomotion. Quercetin reversed the PSD-induced decrease in glutathione (GSH) levels in the prefrontal cortex (PFC) and striatum. Quercetin also reversed the PSD-induced increase in lipid peroxidation (LPO) in the PFC, hippocampus, and striatum. Pearson's correlation analysis revealed a negative correlation between locomotor activity and GSH in the PFC in sleep-deprived mice and a positive correlation between locomotor activity and LPO in the PFC and striatum in sleep-deprived mice. These results suggest that quercetin exerts an antimanic-like effect at doses that do not impair spontaneous locomotor activity, and the antioxidant action of quercetin might contribute to its antimanic-like effects.
authors.affiliation: Laboratory of Physiology and Pharmacology of the Central Nervous System, Department of Pharmacology, Federal University of Paraná, Centro Politécnico, 81540-990 Curitiba, PR, Brazil.
authors.forename: Luiz K S
authors.initials: LKS
authors.lastname: Kanazawa
authors.affiliation: Laboratory of Physiology and Pharmacology of the Central Nervous System, Department of Pharmacology, Federal University of Paraná, Centro Politécnico, 81540-990 Curitiba, PR, Brazil.
authors.forename: Débora D
authors.initials: DD
authors.lastname: Vecchia
authors.affiliation: Laboratory of Physiology and Pharmacology of the Central Nervous System, Department of Pharmacology, Federal University of Paraná, Centro Politécnico, 81540-990 Curitiba, PR, Brazil.
authors.forename: Etiéli M
authors.initials: EM
authors.lastname: Wendler
authors.affiliation: Laboratory of Physiology and Pharmacology of the Central Nervous System, Department of Pharmacology, Federal University of Paraná, Centro Politécnico, 81540-990 Curitiba, PR, Brazil.
authors.forename: Palloma de A S
authors.initials: PAS
authors.lastname: Hocayen
authors.affiliation: Laboratory of Pharmacology and Metabolism, Department of Pharmacology, Federal University of Paraná, Centro Politécnico, 81540-990 Curitiba, PR, Brazil.
authors.forename: Francislaine A
authors.initials: FA
authors.lastname: Dos Reis Lívero
authors.affiliation: Laboratory of Pharmacology and Metabolism, Department of Pharmacology, Federal University of Paraná, Centro Politécnico, 81540-990 Curitiba, PR, Brazil.
authors.forename: Maria Carolina
authors.initials: MC
authors.lastname: Stipp
authors.affiliation: Laboratory of Physiology and Pharmacology of the Central Nervous System, Department of Pharmacology, Federal University of Paraná, Centro Politécnico, 81540-990 Curitiba, PR, Brazil.
authors.forename: Inara M R
authors.initials: IMR
authors.lastname: Barcaro
authors.affiliation: Laboratory of Pharmacology and Metabolism, Department of Pharmacology, Federal University of Paraná, Centro Politécnico, 81540-990 Curitiba, PR, Brazil.
authors.forename: Alexandra
authors.initials: A
authors.lastname: Acco
authors.affiliation: Laboratory of Physiology and Pharmacology of the Central Nervous System, Department of Pharmacology, Federal University of Paraná, Centro Politécnico, 81540-990 Curitiba, PR, Brazil. Electronic address: randreatini@ufpr.br.
authors.forename: Roberto
authors.initials: R
authors.lastname: Andreatini
mesh_terms: D000818:Animals; D018692:Antimanic Agents / Q000494:pharmacology*; D000975:Antioxidants / Q000494:pharmacology*; D001714:Bipolar Disorder / Q000188:drug therapy* / Q000209:etiology / Q000378:metabolism / Q000503:physiopathology; D003342:Corpus Striatum / Q000187:drug effects / Q000378:metabolism; D004195:Disease Models, Animal; D004334:Drug Administration Schedule; D005978:Glutathione / Q000819:agonists / Q000378:metabolism; D006624:Hippocampus / Q000187:drug effects / Q000378:metabolism; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D051379:Mice; D018384:Oxidative Stress / Q000187:drug effects*; D017397:Prefrontal Cortex / Q000187:drug effects / Q000378:metabolism; D011595:Psychomotor Agitation / Q000188:drug therapy* / Q000209:etiology / Q000378:metabolism / Q000503:physiopathology; D011794:Quercetin / Q000494:pharmacology*; D012892:Sleep Deprivation / Q000150:complications / Q000378:metabolism / Q000503:physiopathology
chemical_list: D018692:Antimanic Agents; D000975:Antioxidants; D011794:Quercetin; D005978:Glutathione
keywords: Bipolar disorder; Mania; Oxidative stress; Paradoxical sleep deprivation; Protein kinase C; Quercetin