title: IGF1R and c-met as therapeutic targets for colorectal cancer.
abstract: The type 1 IGF receptor (IGF1R) and mesenchymal-epithelial transition (MET) are hetrodimeric and transmembrane receptor tyrosine kinases, which are frequently overexpressed by several tumor types, including colorectal cancer (CRC). These receptors bind to their specific ligands, insulin growth factors (IGFs) and hepatocyte growth factor (HGF), respectively, and promote signaling cascades which mediates many functions such as proliferation and protection against apoptosis, cell scattering, tumor cell motility, invasion and metastasis. In patients with metastatic colorectal cancer (mCRC), IGF1R and c-met expression confer resistance to cetuximab (monoclonal antibodies against EGFR). Therefore, the c-met and IGF1R are now an attractive novel target for anticancer therapy. In this review, we will describe correlation between two receptors and their activation effects in tumor cells, and finally introduce useful and available strategies for their targeting.
authors.affiliation: Liver and Gastrointestinal Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran; Student's Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.
authors.forename: Hajar
authors.initials: H
authors.lastname: Shali
authors.affiliation: Immunology research center, Tabriz University of Medical Sciences, Tabriz, Iran; Department of Immunology, School of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
authors.forename: Majid
authors.initials: M
authors.lastname: Ahmadi
authors.affiliation: Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
authors.forename: Hossein Samadi
authors.initials: HS
authors.lastname: Kafil
authors.affiliation: Department of Anesthesiology, School of Medicine, Imam reza Hospital, Tabriz University of Medical Sciences, Tabriz, Iran. Electronic address: Dorostia@gmail.com.
authors.forename: Abbasali
authors.initials: A
authors.lastname: Dorosti
authors.affiliation: Immunology research center, Tabriz University of Medical Sciences, Tabriz, Iran; Department of Immunology, School of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran. Electronic address: Yousefime@tbzmed.ac.ir.
authors.forename: Mehdi
authors.initials: M
authors.lastname: Yousefi
mesh_terms: D000818:Animals; D015179:Colorectal Neoplasms / Q000378:metabolism* / Q000628:therapy*; D006801:Humans; D008954:Models, Biological; D058990:Molecular Targeted Therapy; D019859:Proto-Oncogene Proteins c-met / Q000378:metabolism*; D017526:Receptor, IGF Type 1 / Q000378:metabolism*
chemical_list: D019859:Proto-Oncogene Proteins c-met; D017526:Receptor, IGF Type 1
keywords: Colorectal cancer; IGF1R; Receptor tyrosine kinase; c-Met