title: High-throughput acoustic separation of platelets from whole blood.
abstract: Platelets contain growth factors which are important in biomedical and clinical applications. In this work, we present an acoustic separation device for high-throughput, non-invasive platelet isolation. In particular, we separated platelets from whole blood at a 10 mL min(-1) throughput, which is three orders of magnitude greater than that of existing acoustic-based platelet separation techniques. Without sample dilution, we observed more than 80% RBC/WBC removal and platelet recovery. High throughput, high separation efficiency, and biocompatibility make this device useful for many clinical applications.
authors.affiliation: Department of Engineering Science and Mechanics, The Pennsylvania State University, University Park, PA 16802, USA.
authors.forename: Yuchao
authors.initials: Y
authors.lastname: Chen
authors.forename: Mengxi
authors.initials: M
authors.lastname: Wu
authors.forename: Liqiang
authors.initials: L
authors.lastname: Ren
authors.forename: Jiayang
authors.initials: J
authors.lastname: Liu
authors.forename: Pamela H
authors.initials: PH
authors.lastname: Whitley
authors.forename: Lin
authors.initials: L
authors.lastname: Wang
authors.forename: Tony Jun
authors.initials: TJ
authors.lastname: Huang
mesh_terms: D000162:Acoustics; D001792:Blood Platelets / Q000166:cytology*; D002469:Cell Separation / Q000379:methods*; D006801:Humans