title: Retrospective study: The diagnostic accuracy of conventional forceps biopsy of gastric epithelial compared to endoscopic submucosal dissection (STROBE compliant).
abstract: Conventional forceps biopsy (CFB) is the most popular way to screen for gastric epithelial neoplasia (GEN) and adenocarcinoma of gastric epithelium. The aim of this study was to compare the diagnostic accuracy between conventional forceps biopsy and endoscopic submucosal dissection (ESD).Four hundred forty-four patients who finally undertook ESD in our hospital were enrolled from Jan 1, 2009 to Sep 1, 2015. We retrospectively assessed the characteristics of pathological results of CFB and ESD.The concordance rate between CFB and ESD specimens was 68.92% (306/444). Men showed a lower concordance rate (63.61% vs 79.33%; P = 0.001) and concordance patients were younger (P = 0.048). In multivariate analysis, men significantly had a lower concordance rate (coefficient -0.730, P = 0.002) and a higher rate of pathological upgrade (coefficient -0.648, P = 0.015). Locations of CFB did not influence the concordance rate statistically.The concordance rate was relatively high in our hospital. According to our analysis, old men plus gastric fundus or antrum of CFB were strongly suggested to perform ESD if precancerous lesions were found. And young women with low-grade intraepithelial neoplasia could select regular follow-up.
authors.affiliation: Department of Gastroenterology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China.
authors.forename: Chao
authors.initials: C
authors.lastname: Lu
authors.forename: Xueyou
authors.initials: X
authors.lastname: Lv
authors.forename: Yiming
authors.initials: Y
authors.lastname: Lin
authors.forename: Dejian
authors.initials: D
authors.lastname: Li
authors.forename: Lihua
authors.initials: L
authors.lastname: Chen
authors.forename: Feng
authors.initials: F
authors.lastname: Ji
authors.forename: Youming
authors.initials: Y
authors.lastname: Li
authors.forename: Chaohui
authors.initials: C
authors.lastname: Yu
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology*; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D001706:Biopsy / Q000379:methods*; D002278:Carcinoma in Situ / Q000473:pathology*; D000069916:Endoscopic Mucosal Resection / Q000379:methods*; D004848:Epithelium / Q000473:pathology*; D005260:Female; D005753:Gastric Mucosa / Q000473:pathology*; D005773:Gastroscopy / Q000379:methods*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D012737:Sex Factors; D013223:Statistics as Topic; D013274:Stomach Neoplasms / Q000473:pathology*; D013525:Surgical Instruments