title: Does Hsp60 Provide a Link between Mitochondrial Stress and Inflammation in Diabetes Mellitus?
abstract: The focus of this review is to summarise the known relationships between the expression of heat shock protein 60 (Hsp60) and its association with the pathogenesis of Type 1 and Type 2 diabetes mellitus. Hsp60 is a mitochondrial stress protein that is induced by mitochondrial impairment. It is known to be secreted from a number of cell types and circulating levels have been documented in both Types 1 and 2 diabetes mellitus patients. The biological significance of extracellular Hsp60, however, remains to be established. We will examine the links between Hsp60 and cellular anti- and proinflammatory processes and specifically address how Hsp60 appears to affect immune inflammation by at least two different mechanisms: as a ligand for innate immune receptors and as an antigen recognised by adaptive immune receptors. We will also look at the role of Hsp60 during immune cell activation in atherosclerosis, a significant risk factor during the pathogenesis of diabetes mellitus.
authors.affiliation: School of Science, University of Waikato, Private Bag 3105, Hamilton 3240, New Zealand.
authors.forename: Joshua
authors.identifier: 0000-0003-0979-417X
authors.initials: J
authors.lastname: Juwono
authors.affiliation: School of Science, University of Waikato, Private Bag 3105, Hamilton 3240, New Zealand.
authors.forename: Ryan D
authors.identifier: 0000-0002-5954-8770
authors.initials: RD
authors.lastname: Martinus
mesh_terms: D050197:Atherosclerosis / Q000276:immunology; D018834:Chaperonin 60 / Q000276:immunology* / Q000378:metabolism; D003920:Diabetes Mellitus / Q000276:immunology* / Q000378:metabolism; D006801:Humans; D007249:Inflammation; D008928:Mitochondria / Q000276:immunology* / Q000378:metabolism
chemical_list: D018834:Chaperonin 60