title: Reference Values of Total Lean Mass, Appendicular Lean Mass, and Fat Mass Measured with Dual-Energy X-ray Absorptiometry in a Healthy Mexican Population.
abstract: The aim of this study was to develop age- and gender-specific reference values of total lean body mass (LBM), appendicular lean body mass (ALBM), and fat mass (FM) by dual-energy X-ray absorptiometry (DXA) data in a healthy Mexican population. A cross-sectional analysis was conducted on 9518 healthy subjects 7-89 years of age participating in the baseline measurement of the Health Workers Cohort Study. Using DXA, LBM, ALBM, and FM were measured. Using these data, LBM index (LBMI), ALBM index (ALBMI), and fat mass index (FMI) were calculated. LMI, ALMI, and FMI were calculated as the LBM, ALBM, and FM kg divided by the height in meters squared. Males and females were analyzed separately; sex-specific means and standard deviations for LBM, ALBM, FM, LBMI, ALBMI, and FMI were calculated. A total of 2829 males and 6694 females were included in the final analysis. Strong sex gaps were observed after 12 years in LBM, ALBM, LBMI, and ALBMI (P < 0.01). LBM and ALBM values continue to increase for males up to age 20; females plateaued approximately after age 15. Significant sex differences were also observed for FM and FMI. Significant sex- and age-related differences exist in LBM, ALBM, and FM in the Mexican population. In addition, given the null data available in this area, these reference values may be useful in the evaluation of a variety of childhood and adult abnormalities involving lean body mass deficits, mainly in the assessment of muscle wasting, with important medical and epidemiological uses.
authors.affiliation: Unidad de Investigación en Epidemiología Clínica, Hospital Infantil de México Federico Gómez, Ciudad de México, Mexico.
authors.forename: Patricia
authors.initials: P
authors.lastname: Clark
authors.affiliation: Unidad de Investigación en Epidemiología Clínica, Hospital Infantil de México Federico Gómez, Ciudad de México, Mexico. edenovag@gmail.com.
authors.forename: Edgar
authors.initials: E
authors.lastname: Denova-Gutiérrez
authors.affiliation: Unidad de Investigación en Epidemiología Clínica, Hospital Infantil de México Federico Gómez, Ciudad de México, Mexico.
authors.forename: Regina
authors.initials: R
authors.lastname: Ambrosi
authors.affiliation: INSERM UMR, University of Lyon, Lyon, France.
authors.forename: Pawel
authors.initials: P
authors.lastname: Szulc
authors.affiliation: Centro Médico Nacional SIGLO XXI, Instituto Mexicano del Seguro Social, Ciudad de México, Mexico.
authors.forename: Rodolfo
authors.initials: R
authors.lastname: Rivas-Ruiz
authors.affiliation: Unidad de Investigación Epidemiológica y en Servicios de Salud, Instituto Mexicano del Seguro Social, Cuernavaca, Mexico.|Centro de Investigación en Salud Poblacional, Instituto Nacional de Salud Pública, Cuernavaca, Mexico.
authors.forename: Jorge
authors.initials: J
authors.lastname: Salmerón
mesh_terms: D015502:Absorptiometry, Photon; D000273:Adipose Tissue / Q000000981:diagnostic imaging*; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001823:Body Composition; D002648:Child; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D018482:Muscle, Skeletal / Q000000981:diagnostic imaging*; D012016:Reference Values; D012727:Sex Characteristics; D055815:Young Adult
keywords: Appendicular lean body mass; Dual-energy X-ray absorptiometry; Fat mass; Health Workers Cohort Study; Lean body mass; Mexican population; Reference values