title: Separation by nanoparticles plasmonic resonance with low stress in microfluidics channel (analytical and design).
abstract: In this study, nanoparticles near-field plasmonic resonance is used to improve the traditional cell separation main outputs such as viability and efficiency. The live cells viability is severely depend on stresses, which are applied on cells in the microfluidics channel. Hence, for improving the cell viability, the enforced stresses inside of the structure should be declined. The major factors of the enforced stresses are related to the electric field non-uniformity, which are attributed to the hurdles and applied voltage magnitude. Therefore, in this study, a new structure is presented and thereby, the magnitude of the applied stresses on live cells is minimised which is contributed to the decreasing the non-uniformity strength of channel. It should be noted that in the new structure two arrays of nanoparticles were used to produce a short range and localised non-uniform electrical field because of their near-field plasmonic resonance. Hence, the enforced stress on the live cell severely decreased at the far-field and confined at the small section of the channel. It is due to, the near-field plasmonic amplitude is dramatically disappeared by increasing distance, hence, the cells far from the nanoparticles will be endured the low level but effective amount of the optical force.
authors.affiliation: Chemical Engineering Department, Bioengineering Division, Hacettepe University, 06800, Ankara, Turkey. tirdad.zey@gmail.com.
authors.forename: Ahmad
authors.initials: A
authors.lastname: SalmanOgli
authors.affiliation: Computer Science Faculty, Tabriz University, Tabriz, Iran.
authors.forename: Farshad
authors.initials: F
authors.lastname: Farhadnia
authors.affiliation: Chemical Engineering Department, Bioengineering Division, Hacettepe University, 06800, Ankara, Turkey.
authors.forename: Erhan
authors.initials: E
authors.lastname: Piskin
mesh_terms: D002469:Cell Separation / Q000295:instrumentation*; D017076:Computer-Aided Design; D004574:Electromagnetic Fields; D004586:Electrophoresis / Q000295:instrumentation*; D004867:Equipment Design; D019544:Equipment Failure Analysis; D056656:Lab-On-A-Chip Devices; D008846:Micromanipulation / Q000295:instrumentation*; D009038:Motion; D053758:Nanoparticles / Q000737:chemistry / Q000528:radiation effects*; D011829:Radiation Dosage; D013314:Stress, Mechanical; D020349:Surface Plasmon Resonance / Q000295:instrumentation*