title: Effect of the Chronic Use of Lithium Carbonate on Induced Tooth Movement in Wistar Rats.
abstract: Patients who seek dental treatment may have bipolar disorder, and lithium carbonate (LC) is the drug of choice used in the treatment of this disorder. Taking into consideration the controversial results found in the literature, and the possible influence of LC on induced tooth movement, the objective was to evaluate tooth movement induced in rats after administration of lithium carbonate. One hundred and ninety-two rats were divided into 3 groups. In the L group, the animals received daily 60mg/kg of LC, they were not subjected to orthodontic movement, and they were euthanized after 33, 37, 44 or 51 days. In the LM group, the LC was administered for 30 days and during the subsequent 3, 7, 14 and 21 days, corresponding to the period of induced tooth movement, and they received a spring that produced a 30cN force. In the SM group, saline solution was applied. Measurements were made of tooth displacement, the numbers of osteoclasts and serum lithium phosphate (PO4), alkaline phosphatase (ALP) and creatinine levels. The tooth displacement was lower in the LM group compared to the SM group at 44 days. A tendency toward reduction in the number of osteoclasts was observed in the LM group compared to the SM group at 44 days. The average lithium were higher in the L and LM groups compared to the SM group. The opposite was observed for the PO4 group. A higher value for the ALP was found in the L group. The average creatinine level was lower in the LM group. LC inhibited tooth movement for 14 days, possibly due to the reduction in the number of osteoclasts.
authors.affiliation: Department of School of Health and Biosciences of Pontifícia Universidade Católica do Paraná, Curitiba, PR, Brazil.
authors.forename: Viviane
authors.initials: V
authors.lastname: da Silva Kagy
authors.affiliation: Department of School of Health and Biosciences of Pontifícia Universidade Católica do Paraná, Curitiba, PR, Brazil.
authors.forename: Luciana
authors.initials: L
authors.lastname: Trevisan Bittencourt Muniz
authors.affiliation: Department of School of Health and Biosciences of Pontifícia Universidade Católica do Paraná, Curitiba, PR, Brazil.
authors.forename: Arieli Carini
authors.initials: AC
authors.lastname: Michels
authors.affiliation: Department of School of Health and Biosciences of Pontifícia Universidade Católica do Paraná, Curitiba, PR, Brazil.
authors.forename: Suelen Teixeira
authors.initials: ST
authors.lastname: Luiz
authors.affiliation: Department of School of Health and Biosciences of Pontifícia Universidade Católica do Paraná, Curitiba, PR, Brazil.
authors.forename: Luciana
authors.initials: L
authors.lastname: Reis Azevedo Alanis
authors.affiliation: Department of School of Health and Biosciences of Pontifícia Universidade Católica do Paraná, Curitiba, PR, Brazil.
authors.forename: João Armando
authors.initials: JA
authors.lastname: Brancher
authors.affiliation: Department of School of Health and Biosciences of Pontifícia Universidade Católica do Paraná, Curitiba, PR, Brazil.
authors.forename: Ana Maria Trindade
authors.initials: AM
authors.lastname: Grégio
authors.affiliation: Department of School of Health and Biosciences of Pontifícia Universidade Católica do Paraná, Curitiba, PR, Brazil.
authors.forename: Sérgio Aparecido
authors.initials: SA
authors.lastname: Ignácio
authors.affiliation: Department of School of Health and Biosciences of Pontifícia Universidade Católica do Paraná, Curitiba, PR, Brazil.
authors.forename: Elisa Souza
authors.initials: ES
authors.lastname: Camargo
authors.affiliation: Department of Stomatology, School of Dentistry, Universidade Federal do Paraná, Curitiba, PR, Brazil.
authors.forename: Maria Ângela Naval
authors.initials: MÂ
authors.lastname: Machado
authors.affiliation: Department of School of Health and Biosciences of Pontifícia Universidade Católica do Paraná, Curitiba, PR, Brazil.
authors.forename: Aline Cristina Batista Rodrigues
authors.identifier: http://orcid.org/0000-0002-1678-9363
authors.initials: AC
authors.lastname: Johann
mesh_terms: D000818:Animals; D018692:Antimanic Agents / Q000008:administration & dosage / Q000009:adverse effects*; D016723:Bone Remodeling / Q000187:drug effects; D004334:Drug Administration Schedule; D016651:Lithium Carbonate / Q000008:administration & dosage / Q000009:adverse effects*; D008297:Male; D009967:Orthodontic Appliances; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors; D014070:Tooth / Q000187:drug effects* / Q000502:physiology; D014086:Tooth Mobility / Q000473:pathology; D014087:Tooth Movement Techniques
chemical_list: D018692:Antimanic Agents; D016651:Lithium Carbonate