title: Protective Effect of Dietary Lily Bulb on Dextran Sulfate Sodium-Induced Colitis in Rats Fed a High-Fat Diet.
abstract: Lily bulb is traditionally consumed in East Asia and contains high amounts of glucomannan. This study investigated the effect of dietary lily bulb on dextran sulfate sodium (DSS)-induced colitis in rats fed a high-fat (HF) diet. Male Sprague-Dawley rats were fed a diet containing 30% beef tallow with or without 7% steamed lily bulb powder for 17 d. Experimental colitis was induced by replacing drinking water with DSS during the last 7 d. The disease activity index (DAI) was significantly lower in the lily bulb+DSS group than in the DSS group on day 17. The fecal abundance of Bifidobacterium was significantly reduced in the DSS group compared with that in the control group, but it was recovered by lily bulb intake. Cecal butyrate, fecal mucins, and alkaline phosphatase (ALP) activity were significantly higher in the DSS group than in the control group. Dietary lily bulb potentiated the increase in cecal butyrate, fecal mucins, and the ALP activity caused by DSS treatment. These results indicate that lily bulb attenuates DSS-induced colitis by modulating colonic microflora, organic acids, mucins, and ALP activity in HF diet-fed rats.
authors.affiliation: Faculty of Human Life Sciences, Fuji Women's University.
authors.forename: Yukako
authors.initials: Y
authors.lastname: Okazaki
authors.forename: Hideyuki
authors.initials: H
authors.lastname: Chiji
authors.forename: Norihisa
authors.initials: N
authors.lastname: Kato
mesh_terms: D000469:Alkaline Phosphatase / Q000378:metabolism; D000818:Animals; D058491:Bacterial Load; D001644:Bifidobacterium; D002087:Butyrates / Q000032:analysis; D002432:Cecum / Q000737:chemistry; D003092:Colitis / Q000139:chemically induced / Q000517:prevention & control*; D016264:Dextran Sulfate / Q000494:pharmacology*; D004032:Diet; D059305:Diet, High-Fat; D005243:Feces / Q000737:chemistry / Q000382:microbiology; D027762:Lilium; D008297:Male; D008351:Mannans; D009077:Mucins / Q000032:analysis; D018517:Plant Roots / Q000737:chemistry; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D002087:Butyrates; D008351:Mannans; D009077:Mucins; C022901:(1-6)-alpha-glucomannan; D016264:Dextran Sulfate; D000469:Alkaline Phosphatase