title: [The clinical manifestation and analysis of eosinophilic granulomatous vasculitis].
abstract: OBJECTIVE
  To evaluate the clinical features, treatment and prognosis of Eosinophilic Granulomatous Vasculitis.
  
  
  METHODS
  We analyzed retrospectively the clinical and laboratory features, treatment and prognosis of 43 patients with Eosinophilic Granulomatous Vasculitis who admitted to the Department of Rheumatology of the First Affiliated University Hospital of Sun Yat-sen University between 2005 and 2014.
  
  
  RESULTS
  Of the 43 patients, 31 patients (72.1%) had allergic symptoms in the disease course and 16 patients (37.2%) had asthma and lung wheezing sound when performing the physical examination.Organs involvements included skin, acra, lung, kidney, central and peripheral nervous system, digestive system and heart.Positive antineutrophilic cytoplasmic antibody (ANCA) which mainly with MPO-ANCA was found in 18 patients (41.9%). Thirty-nine patients (90.7%)had high blood eosinophil level while all patients (100%) had elevated IgE.Two patients died of multiple organ failure in their acute phase, and the others had favorable prognosis after receiving the treatment of glucocorticoid combine with cyclophosphamide or methotrexate.
  
  
  CONCLUSIONS
  Eosinophilic Granulomatous Vasculitiscould make damage to organs and tissues.Only 72.1% patients had allergic symptoms and 37.2% patients had asthma and lung wheezing sound.More than half patients have the negative ANCA.Glucocorticoidcombine with cyclophosphamide or methotrexate can achieve satisfactory therapeutic effects.
authors.affiliation: Department of Rheumatology, the First Affiliated Hospital of Sun Yet-sen University, Guangzhou 510080, China.
authors.forename: F
authors.initials: F
authors.lastname: Su
authors.forename: Q
authors.initials: Q
authors.lastname: Qiu
authors.forename: D M
authors.initials: DM
authors.lastname: Cai
authors.forename: L Q
authors.initials: LQ
authors.lastname: Liang
authors.forename: X Y
authors.initials: XY
authors.lastname: Yang
mesh_terms: D015267:Churg-Strauss Syndrome; D003520:Cyclophosphamide; D006801:Humans; D007668:Kidney; D008168:Lung; D008727:Methotrexate; D011379:Prognosis; D012189:Retrospective Studies; D012867:Skin
chemical_list: D003520:Cyclophosphamide; D008727:Methotrexate