title: Comparison of two apheresis systems during hematopoietic progenitor stem cell collections at a tertiary medical center.
abstract: BACKGROUND
  The Spectra Optia is a newer apheresis system developed based on the COBE Spectra platform. COBE Spectra requires more manual control, while Spectra Optia offers greater automation. The purpose of this study was to compare the two systems during hematopoietic progenitor stem cell (HPSC) collections.
  
  
  METHODS
  A retrospective review of 41 collections performed in 26 subjects at a tertiary medical center between June 1, 2013, and December 31, 2013, was conducted, 11 with the Spectra Optia and 30 with the COBE Spectra. Six patients underwent two consecutive daily collections, first on the Spectra Optia followed by the COBE Spectra.
  
  
  RESULTS
  Procedure run time with the Spectra Optia was considerably longer than with the COBE Spectra (283 ± 11 min vs. 217 ± 2 min, respectively; p < 0.01). Mean CD34+ cell yields with the Spectra Optia were comparable with those of the COBE Spectra. Products collected with the Spectra Optia had less red blood cell contamination. However, platelet (PLT) attrition was greater with the Spectra Optia. Similar results were obtained in patients who were collected on consecutive days in both systems.
  
  
  CONCLUSIONS
  Collections with the Spectra Optia take longer and lead to greater PLT losses during HPSC collections.
authors.affiliation: Department of Pathology, University Hospitals Case Medical Center; and the, Cleveland, Ohio.|Case Western Reserve University School of Medicine, Cleveland, Ohio.
authors.forename: Yanchun
authors.initials: Y
authors.lastname: Li
authors.affiliation: Department of Pathology, University Hospitals Case Medical Center; and the, Cleveland, Ohio.|Case Western Reserve University School of Medicine, Cleveland, Ohio.
authors.forename: Jie
authors.initials: J
authors.lastname: Li
authors.affiliation: Department of Pathology, University Hospitals Case Medical Center; and the, Cleveland, Ohio.|Case Western Reserve University School of Medicine, Cleveland, Ohio.
authors.forename: Hollie M
authors.initials: HM
authors.lastname: Reeves
authors.affiliation: Department of Pathology, University Hospitals Case Medical Center; and the, Cleveland, Ohio.
authors.forename: Ramil
authors.initials: R
authors.lastname: Reyes
authors.affiliation: Department of Pathology, University Hospitals Case Medical Center; and the, Cleveland, Ohio.|Case Western Reserve University School of Medicine, Cleveland, Ohio.
authors.forename: Robert W
authors.initials: RW
authors.lastname: Maitta
mesh_terms: D000328:Adult; D000368:Aged; D018952:Antigens, CD34 / Q000032:analysis*; D001781:Blood Component Removal / Q000295:instrumentation* / Q000592:standards; D001792:Blood Platelets; D002469:Cell Separation; D004866:Equipment Contamination; D005260:Female; D006412:Hematopoietic Stem Cells / Q000166:cytology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D062606:Tertiary Care Centers; D013997:Time Factors; D055815:Young Adult
chemical_list: D018952:Antigens, CD34