title: Gaps in Research on Adverse Events to Transfusion in Pediatrics.
abstract: Adverse consequences of blood transfusion in children are not completely understood. Much remains to be learned about defining their mechanisms, learning how they can be avoided, and improving our understanding how to minimize the morbidity of their consequences. All types of transfusion reactions can occur in children. This article focuses on four adverse consequences that have particular relevance for pediatric populations: cytomegalovirus transmission, red blood cell alloimmunization, immune altering consequences of transfusion, and necrotizing enterocolitis.
authors.affiliation: St. Louis, MO.
authors.forename: Ronald
authors.initials: R
authors.lastname: Jackups
authors.affiliation: Boston, MA. Electronic address: wjsavage@partners.org.
authors.forename: William
authors.initials: W
authors.lastname: Savage
mesh_terms: D000483:Alleles; D000740:Anemia / Q000517:prevention & control; D001787:Blood Group Incompatibility / Q000276:immunology*; D001803:Blood Transfusion; D002648:Child; D003586:Cytomegalovirus Infections / Q000635:transmission*; D020345:Enterocolitis, Necrotizing / Q000517:prevention & control*; D017707:Erythrocyte Transfusion / Q000009:adverse effects* / Q000379:methods; D004912:Erythrocytes / Q000276:immunology; D005260:Female; D006405:Hematology / Q000379:methods / Q000639:trends; D006801:Humans; D007107:Immune System; D007114:Immunization; D008297:Male; D010372:Pediatrics / Q000379:methods; D017713:Platelet Transfusion; D012306:Risk; D065227:Transfusion Reaction
keywords: Pediatric; Transfusion; Transfusion complications; Transfusion reaction