title: Online Registry for Nationwide Database of Current Trend of Helicobacter pylori Eradication in Korea: Interim Analysis.
abstract: Eradication of Helicobacter pylori using first-line therapy is becoming less effective. Subjects who had been treated for H. pylori infection were prospectively enrolled through an on-line database registry from October 2010 to December 2012. Demographic data, detection methods, treatment indication, regimens, durations, compliance, adverse events, and eradication results for H. pylori infection were collected. Data of 3,700 patients from 34 hospitals were analyzed. The overall eradication rate of the first-line therapy was 73.0%. Eradication failure was significantly associated with old age, concomitant medication, and comorbidity. Regional differences in eradication rates were observed. The most common first-line therapy was proton pump inhibitor-based triple therapy (standard triple therapy, STT) for 7 days (86.8%). The eradication rates varied with regimens, being 73% in STT, 81.8% in bismuth-based quadruple therapy, 100% in sequential therapy, and 90.3% in concomitant therapy. The eradication rate in treatment-naïve patients was higher than that in patients previously treated for H. pylori infection (73.8% vs. 58.5%, P < 0.001). The overall eradication rate for second-line therapy was 84.3%. There was no statistical difference in eradication rates among various regimens. H. pylori eradication rate using STT is decreasing in Korea and has become sub-optimal, suggesting the need for alternative regimens to improve the efficacy of first-line therapy for H. pylori infection.
authors.affiliation: Department of Internal Medicine, Chung-Ang University College of Medicine, Seoul, Korea .
authors.forename: Beom Jin
authors.identifier: 0000-0002-0938-6697
authors.initials: BJ
authors.lastname: Kim
authors.affiliation: Department of Internal Medicine, Chonnam National University Medical School, Gwangju, Korea .
authors.forename: Hyun-Soo
authors.identifier: 0000-0003-4834-0496
authors.initials: HS
authors.lastname: Kim
authors.affiliation: Department of Internal Medicine, Jeju National University School of Medicine, Jeju, Korea .
authors.forename: Hyun Joo
authors.identifier: 0000-0002-4107-9590
authors.initials: HJ
authors.lastname: Song
authors.affiliation: Department of Internal Medicine, Cheonan Hospital, Soon Chun Hyang University College of Medicine, Cheonan, Korea .
authors.forename: Il-Kwun
authors.identifier: 0000-0001-6732-9714
authors.initials: IK
authors.lastname: Chung
authors.affiliation: Department of Internal Medicine, Pusan National University School of Medicine, Busan, Korea .
authors.forename: Gwang Ha
authors.identifier: 0000-0001-9721-5734
authors.initials: GH
authors.lastname: Kim
authors.affiliation: Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Incheon, Korea .
authors.forename: Byung-Wook
authors.identifier: 0000-0002-2290-4954
authors.initials: BW
authors.lastname: Kim
authors.affiliation: Department of Internal Medicine, Ewha Womans University School of Medicine, Seoul, Korea .
authors.forename: Ki-Nam
authors.identifier: 0000-0003-4004-6292
authors.initials: KN
authors.lastname: Shim
authors.affiliation: Department of Internal Medicine, Kyungpook National University Medical Center, Daegu, Korea .
authors.forename: Seong Woo
authors.identifier: 0000-0002-9539-9389
authors.initials: SW
authors.lastname: Jeon
authors.affiliation: Department of Internal Medicine, Daegu Fatima Hospital, Daegu, Korea .
authors.forename: Yun Jin
authors.identifier: 0000-0002-3622-9216
authors.initials: YJ
authors.lastname: Jung
authors.affiliation: Department of Internal Medicine, Dongguk University College of Medicine Gyeongju Hospital, Gyeongju, Korea .
authors.forename: Chang-Hun
authors.identifier: 0000-0003-4036-2981
authors.initials: CH
authors.lastname: Yang
authors.affiliation: Department of Internal Medicine, Pusan Paik Hospital, Inje University College of Medicine, Busan, Korea .
authors.forename: Ji Hyun
authors.identifier: 0000-0003-0861-2792
authors.initials: JH
authors.lastname: Kim
authors.affiliation: Department of Gastroenterolgy, Bucheon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Bucheon, Korea .
authors.forename: Tae Ho
authors.identifier: 0000-0003-2015-5176
authors.initials: TH
authors.lastname: Kim
authors.affiliation: Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul, Korea .
authors.forename: Sang Gyun
authors.identifier: 0000-0003-1799-9028
authors.initials: SG
authors.lastname: Kim
authors.affiliation: Department of Internal Medicine, Kangdong Sacred Heart Hospital, Hallym University College of Medicine, Seoul, Korea .
authors.forename: Woon Geon
authors.identifier: 0000-0002-9851-5576
authors.initials: WG
authors.lastname: Shin
authors.affiliation: Department of Internal Medicine, Konyang University College of Medicine, Daejeon, Korea .
authors.forename: Sun Moon
authors.identifier: 0000-0002-0436-3381
authors.initials: SM
authors.lastname: Kim
authors.affiliation: Department of Gastroenterolgy, Bucheon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Bucheon, Korea .
authors.forename: Sok Won
authors.identifier: 0000-0003-2705-778X
authors.initials: SW
authors.lastname: Han
authors.affiliation: Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea .
authors.forename: Jun Haeng
authors.identifier: 0000-0002-5272-1841
authors.initials: JH
authors.lastname: Lee
authors.affiliation: Department of Internal Medicine, Kangdong Sacred Heart Hospital, Hallym University College of Medicine, Seoul, Korea .
authors.forename: Kyung Ho
authors.identifier: 0000-0002-9607-6258
authors.initials: KH
authors.lastname: Kim
authors.affiliation: Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Korea.; Department of Biomedical Science, Seoul National University Graduate School, Seoul, Korea.; Cancer Research Institute, Seoul National University, Seoul, Korea.
authors.forename: Sue K
authors.identifier: 0000-0001-5002-9707
authors.initials: SK
authors.lastname: Park
authors.affiliation: Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Korea .
authors.forename: Byung-Joo
authors.identifier: 0000-0003-4630-4942
authors.initials: BJ
authors.lastname: Park
authors.affiliation: Department of Biomedical Science, Seoul National University Graduate School, Seoul, Korea .
authors.forename: Joongyub
authors.identifier: 0000-0003-2784-3772
authors.initials: J
authors.lastname: Lee
authors.affiliation: Department of Internal Medicine, Chung-Ang University College of Medicine, Seoul, Korea .
authors.forename: Jae G
authors.identifier: 0000-0002-4841-9404
authors.initials: JG
authors.lastname: Kim
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D016208:Databases, Factual; D004359:Drug Therapy, Combination; D005260:Female; D016481:Helicobacter Infections / Q000188:drug therapy* / Q000382:microbiology; D016480:Helicobacter pylori / Q000302:isolation & purification; D006801:Humans; D020407:Internet; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D054328:Proton Pump Inhibitors / Q000627:therapeutic use*; D012042:Registries; D056910:Republic of Korea; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents; D054328:Proton Pump Inhibitors
keywords: Eradication Success; First-line Therapy; Helicobacter pylori; On-line Registry