title: Motion of tympanic membrane in guinea pig otitis media model measured by scanning laser Doppler vibrometry.
abstract: Otitis media (OM) is an inflammatory or infectious disease of the middle ear. Acute otitis media (AOM) and otitis media with effusion (OME) are the two major types of OM. However, the tympanic membrane (TM) motion differences induced by AOM and OME have not been quantified in animal models in the literature. In this study, the guinea pig AOM and OME models were created by transbullar injection of Streptococcus pneumoniae type 3 and lipopolysaccharide, respectively. To explore the effects of OM on the entire TM vibration, the measurements of full-field TM motions were performed in the AOM, OME and untreated control ears by using scanning laser Doppler vibrometry (SLDV). The results showed that both AOM and OME generally reduced the displacement peak and produced the traveling-wave-like motions at relatively low frequencies. Compared with the normal ear, OME resulted in a significant change of the TM displacement mainly in the inferior portion of the TM, and AOM significantly affected the surface motion across four quadrants. The SLDV measurements provide more insight into sound-induced TM vibration in diseased ears.
authors.affiliation: School of Aerospace and Mechanical Engineering and Biomedical Engineering Center, University of Oklahoma, Norman, OK, USA.
authors.forename: Xuelin
authors.initials: X
authors.lastname: Wang
authors.affiliation: School of Aerospace and Mechanical Engineering and Biomedical Engineering Center, University of Oklahoma, Norman, OK, USA.
authors.forename: Xiying
authors.initials: X
authors.lastname: Guan
authors.affiliation: Polytec Inc., Irvine, CA, USA.
authors.forename: Mario
authors.initials: M
authors.lastname: Pineda
authors.affiliation: School of Aerospace and Mechanical Engineering and Biomedical Engineering Center, University of Oklahoma, Norman, OK, USA. Electronic address: rgan@ou.edu.
authors.forename: Rong Z
authors.initials: RZ
authors.lastname: Gan
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D004432:Ear, Middle / Q000000981:diagnostic imaging; D006168:Guinea Pigs; D017078:Laser-Doppler Flowmetry; D008070:Lipopolysaccharides / Q000737:chemistry; D009038:Motion; D010033:Otitis Media / Q000000981:diagnostic imaging* / Q000503:physiopathology; D010034:Otitis Media with Effusion / Q000000981:diagnostic imaging* / Q000503:physiopathology; D014432:Tympanic Membrane / Q000000981:diagnostic imaging* / Q000503:physiopathology; D014732:Vibration
chemical_list: D008070:Lipopolysaccharides
keywords: Acute otitis media; Middle ear; Otitis media with effusion; Tympanic membrane