title: Ever HRD a ubiquitin-gated channel?
abstract: Elimination of misfolded proteins of the endoplasmic reticulum (ER) requires their retrotranslocation from the ER to the cytosol via membrane-bound ubiquitin ligase complexes. Baldridge and Rapoport now reconstitute a key step of retrotranslocation, demonstrating a protein conduit gated by ubiquitination.
authors.affiliation: Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
authors.forename: Ting
authors.initials: T
authors.lastname: Zhang
authors.affiliation: Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
authors.forename: Yihong
authors.initials: Y
authors.lastname: Ye
mesh_terms: D060746:Endoplasmic Reticulum-Associated Degradation; D017510:Protein Folding; D012441:Saccharomyces cerevisiae; D029701:Saccharomyces cerevisiae Proteins; D025801:Ubiquitin; D044767:Ubiquitin-Protein Ligases
chemical_list: D029701:Saccharomyces cerevisiae Proteins; D025801:Ubiquitin; C104621:HRD1 protein, S cerevisiae; D044767:Ubiquitin-Protein Ligases