title: REM sleep behavior disorder was associated with Parkinson's disease: a community-based study.
abstract: BACKGROUND
  Our study was aimed to validate a modified RBD (REM sleep behavior disorder) single question (RBD1Q-C), study the prevalence of probable RBD (pRBD) in a rural community based on RBD1Q-C and investigate the association between pRBD and Parkinson's disease (PD).
  
  
  METHODS
  The validation study of RBD1Q-C included 32 Chinese participants (14 idiopathic RBD patients and 18 controls). All participants underwent a polysomnogram (PSG). We then conducted a door-to-door survey to estimate the prevalence of pRBD assessed by RBD1Q-C, and its association with PD among 19614 residents who lived in Malu community of Shanghai, China.
  
  
  RESULTS
  RBD1Q-C demonstrated a high sensitivity of 100%, a moderate specificity of 55.6%. The agreement between RBD1Q-C and PSG-based RBD diagnosis was good (k = 0.552). PPV of the RBD1Q-C was 63.6% and NPV was 100%. The prevalence of pRBD in Malu community was 4.9%. In people over 50 years old, presence of pRBD was significantly associated with increased risk of having PD (odds ratio = 2.61, 95% CI: 1.56-4.39).
  
  
  CONCLUSIONS
  RBD1Q-C was shown to be a useful screening tool. Based on the RBD1Q-C, we found that pRBD was not rare in Chinese rural population and associated with odds of PD, calling for more attention from patients, caregivers and physicians.
authors.affiliation: Department of Neurology and Institute of Neurology, Ruijin Hospital affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, People's Republic of China.
authors.forename: Jian-Fang
authors.initials: JF
authors.lastname: Ma
authors.affiliation: Department of Neurology and Institute of Neurology, Ruijin Hospital affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, People's Republic of China.
authors.forename: Miao-Miao
authors.initials: MM
authors.lastname: Hou
authors.affiliation: Department of Neurology and Institute of Neurology, Ruijin Hospital affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, People's Republic of China.
authors.forename: Hui-Dong
authors.initials: HD
authors.lastname: Tang
authors.affiliation: Department of Nutritional Sciences, The Pennsylvania State University, University Park, PA, 16802, USA.
authors.forename: Xiang
authors.initials: X
authors.lastname: Gao
authors.affiliation: Department of Neurology and Institute of Neurology, Ruijin Hospital affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, People's Republic of China.
authors.forename: Liang
authors.initials: L
authors.lastname: Liang
authors.affiliation: Malu Medical Center, Jia Ding district, Shanghai, 201800, People's Republic of China.
authors.forename: Li-Fang
authors.initials: LF
authors.lastname: Zhu
authors.affiliation: Department of Neurology and Institute of Neurology, Ruijin Hospital affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, People's Republic of China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Zhou
authors.affiliation: Department of Neurology and Institute of Neurology, Ruijin Hospital affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, People's Republic of China.
authors.forename: Sheng-Yu
authors.initials: SY
authors.lastname: Zha
authors.affiliation: Department of Neurology and Institute of Neurology, Ruijin Hospital affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, People's Republic of China.
authors.forename: Shi-Shuang
authors.initials: SS
authors.lastname: Cui
authors.affiliation: Department of Neurology and Institute of Neurology, Ruijin Hospital affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, People's Republic of China.
authors.forename: Juan-Juan
authors.initials: JJ
authors.lastname: Du
authors.affiliation: Department of Neurology and Institute of Neurology, Ruijin Hospital affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, People's Republic of China.
authors.forename: Gen
authors.initials: G
authors.lastname: Li
authors.affiliation: Department of Neurology and Institute of Neurology, Ruijin Hospital affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, People's Republic of China. jly0520@hotmail.com.
authors.forename: Jun
authors.initials: J
authors.lastname: Liu
authors.affiliation: Department of Neurology and Institute of Neurology, Ruijin Hospital affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, People's Republic of China. Chen_sd@medmail.com.cn.
authors.forename: Sheng-Di
authors.initials: SD
authors.lastname: Chen
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002681:China / Q000453:epidemiology; D005260:Female; D006801:Humans; D008297:Male; D008403:Mass Screening / Q000706:statistics & numerical data*; D008875:Middle Aged; D010300:Parkinson Disease / Q000453:epidemiology*; D017286:Polysomnography / Q000379:methods; D011159:Population Surveillance; D011237:Predictive Value of Tests; D015995:Prevalence; D020187:REM Sleep Behavior Disorder / Q000453:epidemiology*; D012423:Rural Health / Q000706:statistics & numerical data*; D012680:Sensitivity and Specificity; D055815:Young Adult
keywords: Community-based study; Parkinson’s disease; Prevalence; REM sleep behavior disorder