title: Xylan-based temperature/pH sensitive hydrogels for drug controlled release.
abstract: Xylan-based temperature/pH sensitive hydrogels were prepared by the crosslinking copolymerization of xylan with N-isopropylacrylamide (NIPAm) and acrylic acid (AA) using N,Ń-methylenebis-acrylamide (MBA) as a cross-linker and 2,2-dimethoxy-2-phenylacetophenone as a photoinitiator via ultraviolet irradiation. The influence of the NIPAm, AA and MBA amount on properties of xylan-based hydrogels was discussed. The morphology and interactions of hydrogels were characterized by SEM and FTIR. The lower critical solution temperature (LCST) of hydrogels was investigated by DSC. The results indicated that the LCST of hydrogels emerged at around 34°C and increased with increasing the AA content. The drug encapsulation efficiency of as-prepared hydrogels reached to 97.60% and the cumulative release rate of acetylsalicylic acid was 90.12% and 26.35% in the intestinal and gastric fluid, respectively. Xylan-based hydrogels were proved to be biocompatible with NIH3T3 cell by MTT assay and showed the promising application as drug carriers for the intestinal-targeted oral drug delivery.
authors.affiliation: State Key Laboratory of Pulp and Paper Engineering, South China University of Technology, Guangzhou, 510640, Guangdong, China.
authors.forename: Cundian
authors.initials: C
authors.lastname: Gao
authors.affiliation: State Key Laboratory of Pulp and Paper Engineering, South China University of Technology, Guangzhou, 510640, Guangdong, China. Electronic address: renjunli@scut.edu.cn.
authors.forename: Junli
authors.initials: J
authors.lastname: Ren
authors.affiliation: State Key Laboratory of Pulp and Paper Engineering, South China University of Technology, Guangzhou, 510640, Guangdong, China.
authors.forename: Cui
authors.initials: C
authors.lastname: Zhao
authors.affiliation: State Key Laboratory of Pulp and Paper Engineering, South China University of Technology, Guangzhou, 510640, Guangdong, China.
authors.forename: Weiqing
authors.initials: W
authors.lastname: Kong
authors.affiliation: State Key Laboratory of Pulp and Paper Engineering, South China University of Technology, Guangzhou, 510640, Guangdong, China.
authors.forename: Qingqing
authors.initials: Q
authors.lastname: Dai
authors.affiliation: State Key Laboratory of Pulp and Paper Engineering, South China University of Technology, Guangzhou, 510640, Guangdong, China.
authors.forename: Qifeng
authors.initials: Q
authors.lastname: Chen
authors.affiliation: State Key Laboratory of Pulp and Paper Engineering, South China University of Technology, Guangzhou, 510640, Guangdong, China.
authors.forename: Chuanfu
authors.initials: C
authors.lastname: Liu
authors.affiliation: Beijing Key Laboratory of Lignocellulosic Chemistry, College of Materials Science and Technology, Beijing Forestry University, Beijing, 100083, China.
authors.forename: Runcang
authors.initials: R
authors.lastname: Sun
mesh_terms: D000098:Acetophenones / Q000737:chemistry; D000178:Acrylamides / Q000737:chemistry; D000180:Acrylic Resins / Q000008:administration & dosage / Q000737:chemistry*; D000818:Animals; D001241:Aspirin / Q000008:administration & dosage / Q000737:chemistry*; D002470:Cell Survival / Q000187:drug effects; D003692:Delayed-Action Preparations / Q000008:administration & dosage / Q000737:chemistry; D004337:Drug Carriers / Q000008:administration & dosage / Q000737:chemistry*; D065546:Drug Liberation; D020100:Hydrogels / Q000008:administration & dosage / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D051379:Mice; D041681:NIH 3T3 Cells; D013696:Temperature; D014466:Ultraviolet Rays; D014990:Xylans / Q000008:administration & dosage / Q000737:chemistry*
chemical_list: D000098:Acetophenones; D000178:Acrylamides; D000180:Acrylic Resins; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D020100:Hydrogels; D014990:Xylans; C452198:2,2-dimethoxy-2-phenylacetophenone; C052970:poly-N-isopropylacrylamide; C021221:N,N'-methylenebisacrylamide; D001241:Aspirin
keywords: Biocompatibility; Drug release; Hydrogels; Temperature/pH sensitivity; Xylan