title: Single cell analysis revealed a coexistence of NOTCH1 and TP53 mutations within the same cancer cells in chronic lymphocytic leukaemia patients.
authors.affiliation: Central European Institute of Technology (CEITEC), Masaryk University, Brno, Czech Republic.
authors.forename: Barbara
authors.initials: B
authors.lastname: Kantorova
authors.affiliation: Central European Institute of Technology (CEITEC), Masaryk University, Brno, Czech Republic.|Department of Internal Medicine - Hematology and Oncology, University Hospital Brno, Brno, Czech Republic.
authors.forename: Jitka
authors.initials: J
authors.lastname: Malcikova
authors.affiliation: Central European Institute of Technology (CEITEC), Masaryk University, Brno, Czech Republic.
authors.forename: Kamila
authors.initials: K
authors.lastname: Brazdilova
authors.affiliation: Department of Internal Medicine - Hematology and Oncology, University Hospital Brno, Brno, Czech Republic.
authors.forename: Marek
authors.initials: M
authors.lastname: Borsky
authors.affiliation: Central European Institute of Technology (CEITEC), Masaryk University, Brno, Czech Republic.|Department of Internal Medicine - Hematology and Oncology, University Hospital Brno, Brno, Czech Republic.
authors.forename: Karla
authors.initials: K
authors.lastname: Plevova
authors.affiliation: Department of Pathology, University Hospital Brno, Brno, Czech Republic.
authors.forename: Jana
authors.initials: J
authors.lastname: Smardova
authors.affiliation: Central European Institute of Technology (CEITEC), Masaryk University, Brno, Czech Republic.
authors.forename: Lenka
authors.initials: L
authors.lastname: Radova
authors.affiliation: Central European Institute of Technology (CEITEC), Masaryk University, Brno, Czech Republic.
authors.forename: Nikola
authors.initials: N
authors.lastname: Tom
authors.affiliation: Department of Internal Medicine - Hematology and Oncology, University Hospital Brno, Brno, Czech Republic.
authors.forename: Martin
authors.initials: M
authors.lastname: Trbusek
authors.affiliation: Department of Internal Medicine - Hematology and Oncology, University Hospital Brno, Brno, Czech Republic.
authors.forename: Eva
authors.initials: E
authors.lastname: Diviskova
authors.affiliation: Department of Internal Medicine - Hematology and Oncology, University Hospital Brno, Brno, Czech Republic.
authors.forename: Hana Skuhrova
authors.initials: HS
authors.lastname: Francova
authors.affiliation: Central European Institute of Technology (CEITEC), Masaryk University, Brno, Czech Republic.
authors.forename: Veronika
authors.initials: V
authors.lastname: Navrkalova
authors.affiliation: Central European Institute of Technology (CEITEC), Masaryk University, Brno, Czech Republic.|Department of Internal Medicine - Hematology and Oncology, University Hospital Brno, Brno, Czech Republic.
authors.forename: Michael
authors.initials: M
authors.lastname: Doubek
authors.affiliation: Department of Internal Medicine - Hematology and Oncology, University Hospital Brno, Brno, Czech Republic.
authors.forename: Yvona
authors.initials: Y
authors.lastname: Brychtova
authors.affiliation: Central European Institute of Technology (CEITEC), Masaryk University, Brno, Czech Republic.|Department of Internal Medicine - Hematology and Oncology, University Hospital Brno, Brno, Czech Republic.
authors.forename: Jiri
authors.initials: J
authors.lastname: Mayer
authors.affiliation: Central European Institute of Technology (CEITEC), Masaryk University, Brno, Czech Republic.|Department of Internal Medicine - Hematology and Oncology, University Hospital Brno, Brno, Czech Republic.
authors.forename: Sarka
authors.initials: S
authors.lastname: Pospisilova
mesh_terms: D000483:Alleles; D060965:Clonal Evolution / Q000235:genetics; D004252:DNA Mutational Analysis / Q000379:methods; D005838:Genotype; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000175:diagnosis* / Q000188:drug therapy / Q000235:genetics*; D051881:Receptor, Notch1 / Q000235:genetics*; D059010:Single-Cell Analysis / Q000379:methods; D016159:Tumor Suppressor Protein p53 / Q000235:genetics*
chemical_list: D051881:Receptor, Notch1; D016159:Tumor Suppressor Protein p53
keywords: 
  CLL
  ; NOTCH1 mutation; TP53 mutations; clonal evolution; single cell analysis