title: A Prognostic Nomogram for Overall Survival of Patients After Hepatectomy for Intrahepatic Cholangiocarcinoma.
abstract: OBJECTIVE
  We hypothesized that a nomogram can accurately predict overall survival (OS) for patients with intrahepatic cholangiocarcinoma (ICC) after hepatectomy.
  
  
  METHODS
  A nomogram to predict OS based was developed using data from 185 ICC patients who had undergone hepatectomy. The nomogram was evaluated by concordance index (C-index), as well as testing calibration of predicted OS with observed OS for both internal and external cohorts.
  
  
  RESULTS
  Ten clinicopathological independent factors for OS prediction were selected for use in the nomogram. For internal validation, the calibration curve for probability of OS showed good agreement between prediction by the nomogram and actual observation. In three external validation cohorts, the nomogram discrimination was also superior to two other staging systems.
  
  
  CONCLUSIONS
  A nomogram integrating ten clinicopathological variables was developed that may assist in individual prognostic prediction of ICC after hepatectomy.
authors.affiliation: General Surgery Department, Chang Gung Memorial Hospital, Linkou Branch, Taoyuan, Taiwan, R.O.C. yehchunnan@gmail.com tsy470127@cgmh.org.tw.
authors.forename: Chun-Nan
authors.initials: CN
authors.lastname: Yeh
authors.affiliation: General Surgery Department, Chang Gung Memorial Hospital, Linkou Branch, Taoyuan, Taiwan, R.O.C. Graduate Institute of Clinical Medical Sciences, Chang Gung University, Taoyuan, Taiwan. R.O.C.
authors.forename: Shang-Yu
authors.initials: SY
authors.lastname: Wang
authors.affiliation: Division of Hematology-Oncology, Department of Internal Medicine, Chang Gung Memorial Hospital, Kaohsiung Branch, Kaohsiung, Taiwan, R.O.C.
authors.forename: Yen-Yang
authors.initials: YY
authors.lastname: Chen
authors.affiliation: Divsion of Hematology and Oncology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan, R.O.C. Institute of Clinical Medicine, National Yang-Ming University, Taipei, Taiwan, R.O.C.
authors.forename: Ming-Huang
authors.initials: MH
authors.lastname: Chen
authors.affiliation: General Surgery Department, Chang Gung Memorial Hospital, Keelung Branch, Keelung, Taiwan, R.O.C.
authors.forename: Kun-Chun
authors.initials: KC
authors.lastname: Chiang
authors.affiliation: General Surgery Department, Chang Gung Memorial Hospital, Linkou Branch, Taoyuan, Taiwan, R.O.C.
authors.forename: Chi-Tung
authors.initials: CT
authors.lastname: Cheng
authors.affiliation: General Surgery Department, Chang Gung Memorial Hospital, Linkou Branch, Taoyuan, Taiwan, R.O.C.
authors.forename: Chun-Yi
authors.initials: CY
authors.lastname: Tsai
authors.affiliation: Department of General Surgery, Chang Gung Memorial Hospital, Kaohsiung Branch, Kaohsiung, Taiwan, R.O.C.
authors.forename: Chih-Chi
authors.initials: CC
authors.lastname: Wang
authors.affiliation: General Surgery Department, Chang Gung Memorial Hospital, Linkou Branch, Taoyuan, Taiwan, R.O.C. yehchunnan@gmail.com tsy470127@cgmh.org.tw.
authors.forename: Ta-Sen
authors.initials: TS
authors.lastname: Yeh
authors.affiliation: Department of Anatomical Biology, Chang Gung Memorial Hospital, Linkow Branch, Taoyuan, Taiwan, R.O.C.
authors.forename: Tse-Ching
authors.initials: TC
authors.lastname: Chen
mesh_terms: D000328:Adult; D000368:Aged; D001650:Bile Duct Neoplasms / Q000453:epidemiology / Q000473:pathology / Q000601:surgery*; D018281:Cholangiocarcinoma / Q000453:epidemiology / Q000473:pathology / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D006498:Hepatectomy; D006801:Humans; D053208:Kaplan-Meier Estimate; D008113:Liver Neoplasms / Q000453:epidemiology / Q000473:pathology / Q000601:surgery*; D008875:Middle Aged; D009367:Neoplasm Staging; D049451:Nomograms; D011379:Prognosis
keywords: Prognosis; cholangiocarcinoma; hepatectomy; nomogram; overall survival