title: Rapid Intracranial Response to Osimertinib in a Patient with Epidermal Growth Factor Receptor T790M-Positive Adenocarcinoma of the Lung.
abstract: BACKGROUND
  Osimertinib (AZD9291, Tagrisso) is a potent, irreversible third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI).
  
  
  METHODS
  Our report demonstrates that osimertinib is able to inhibit the growth of a radiotherapy- and surgery-refractory EGFR T790M-positive brain metastasis in a patient with lung adenocarcinoma.
  
  
  CONCLUSIONS
  These data show that re-biopsy in EGFR-mutated non-small cell lung cancer patients with acquired TKI resistance should be performed.
authors.affiliation: Department of Medical Oncology and Hematology, Kantonsspital St. Gallen, St. Gallen, Switzerland.
authors.forename: Hermann
authors.initials: H
authors.lastname: Reichegger
authors.forename: Wolfram
authors.initials: W
authors.lastname: Jochum
authors.forename: Diana
authors.initials: D
authors.lastname: Förbs
authors.forename: Claudia
authors.initials: C
authors.lastname: Hader
authors.forename: Martin
authors.initials: M
authors.lastname: Früh
mesh_terms: D000178:Acrylamides; D000230:Adenocarcinoma / Q000188:drug therapy* / Q000235:genetics / Q000556:secondary*; D000328:Adult; D000814:Aniline Compounds; D000970:Antineoplastic Agents / Q000008:administration & dosage; D001932:Brain Neoplasms / Q000188:drug therapy* / Q000235:genetics / Q000556:secondary*; D066246:ErbB Receptors / Q000235:genetics*; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy / Q000235:genetics*; D010879:Piperazines / Q000008:administration & dosage*; D017354:Point Mutation / Q000235:genetics; D047428:Protein Kinase Inhibitors / Q000008:administration & dosage; D016896:Treatment Outcome; D007211:Indoles; D011743:Pyrimidines
chemical_list: D000178:Acrylamides; D000814:Aniline Compounds; D000970:Antineoplastic Agents; D066246:ErbB Receptors; D010879:Piperazines; D047428:Protein Kinase Inhibitors; C000596361:osimertinib; D007211:Indoles; D011743:Pyrimidines