title: Brachial artery flow-mediated dilatation and carotid intima-media thickness in young ED patients with insulin resistance.
abstract: The evidence of a close relationship between cardiovascular disease and erectile dysfunction (ED) is well documented. The aim of this study is to investigate whether there is an early asymptomatic impairment of the peripheral vasculature in young ED patients without obvious cardiovascular disease. We studied a total of 261 ED patients (19-40 years old) and 40 age-matched healthy controls. All participants received questionnaires of cardiovascular risk factors and erectile function assessment, were subjected to lab tests of fasting blood sample, and underwent the ultrasonographic examination of brachial artery flow-mediated dilation (FMD) and carotid intima-media thickness (c-IMT). Insulin resistance (IR) was measured by the homeostasis model assessment of insulin resistance (HOMA-IR). Compared with normal human controls, FMD was significantly lower, whereas the average c-IMT was significantly greater in ED patients. An inverse correlation was found between FMD and mean c-IMT. The ED patients had significantly higher levels of fasting glucose, fasting insulin and HOMA-IR index, but showed relatively lower total testosterone and prolactin levels than the controls. Both FMD and c-IMT showed a significant correlation with International Index of Erectile Function-5 questionnaire (IIEF-5) score, age and HOMA-IR. Multivariate stepwise regression analysis demonstrated that age, HOMA-IR and IIEF-5 score were the risk factors associated with FMD and c-IMT. In conclusion, young ED patients in association with IR display diminished FMD and increased c-IMT. Furthermore, ED, HOMA-IR and age are independent predictors of the two subclinical atherosclerotic markers.
authors.affiliation: Department of Urology, First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.|Department of Obstetrics and Gynaecology, Sun Yat-sen Memorial Hospital of Sun Yat-sen University, Guangzhou, China.
authors.forename: S-F
authors.initials: SF
authors.lastname: Chen
authors.affiliation: Department of Ultrasonography, First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.
authors.forename: F-J
authors.initials: FJ
authors.lastname: Yao
authors.affiliation: Department of Urology, First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.
authors.forename: X-Z
authors.initials: XZ
authors.lastname: Sun
authors.affiliation: Department of Urology, First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.
authors.forename: R-P
authors.initials: RP
authors.lastname: Wu
authors.affiliation: Department of Urology, Shanghai Institute of Andrology, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
authors.forename: Y-P
authors.initials: YP
authors.lastname: Huang
authors.affiliation: Department of Urology, First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.
authors.forename: F-F
authors.initials: FF
authors.lastname: Zheng
authors.affiliation: Department of Urology, First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.
authors.forename: Q-Y
authors.initials: QY
authors.lastname: Yang
authors.affiliation: Department of Urology, First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.
authors.forename: D-Y
authors.initials: DY
authors.lastname: Han
authors.affiliation: Department of Obstetrics and Gynaecology, Sun Yat-sen Memorial Hospital of Sun Yat-sen University, Guangzhou, China.
authors.forename: M-Q
authors.initials: MQ
authors.lastname: Xie
authors.affiliation: Department of Obstetrics and Gynaecology, Sun Yat-sen Memorial Hospital of Sun Yat-sen University, Guangzhou, China.
authors.forename: M
authors.initials: M
authors.lastname: Ding
authors.affiliation: Division of Cardiology, First Affiliated Hospital, Sun Yat-sen University, Key Laboratory on Assisted Circulation, Ministry of Health, Guangzhou, China.
authors.forename: Y
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Reproductive Medicine Center, Sixth Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
authors.forename: G-H
authors.initials: GH
authors.lastname: Liu
authors.affiliation: Department of Urology, First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.
authors.forename: C-H
authors.initials: CH
authors.lastname: Deng
mesh_terms: D000328:Adult; D001786:Blood Glucose; D001916:Brachial Artery / Q000000981:diagnostic imaging / Q000503:physiopathology*; D059168:Carotid Intima-Media Thickness; D007172:Erectile Dysfunction / Q000097:blood / Q000000981:diagnostic imaging / Q000503:physiopathology*; D006801:Humans; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance / Q000502:physiology*; D008297:Male; D011388:Prolactin / Q000097:blood; D013739:Testosterone / Q000097:blood; D018616:Ultrasonography, Doppler, Duplex; D055815:Young Adult
chemical_list: D001786:Blood Glucose; D007328:Insulin; D013739:Testosterone; D011388:Prolactin