title: Neuropathic pain in cancer patients treated with bortezomib.
abstract: BACKGROUND
  The neuropathic pain is the most habitual problem in the neuropathy induced by chemotherapy (NIQ) and the one that more interferes in the quality of life of the patients. His precocious detection turns out to be fundamental to reduce or to eliminate the problems that from this one stem. The aims of this study were: 1) determine the incident and NIQ's characteristics and neuropathic pain in patients with mieloma multiple (MM) treated with bortezomib, and 2) to evaluate the impact of the neuropathic pain in the activities of the daily life (AVD).
  
  
  METHODS
  All the patients diagnosed of MM candidates for treatment with bortezomib attended in the Hospital Joan XXIII during 2013, took part. The participants were interviewed individually and were reporting on the presence, the characteristics and the impact of the pain, as well as of the adverse effects of the bortezomib.
  
  
  RESULTS
  There took part 22 persons, of which NIQ presented the half, being the degree 2 the predominant one. The most habitual location of the neuropathic pain was hands and feet; it was appearing in a spontaneous and progressive way deteriorating in rest and during the night, with predominance of positive symptoms. The impact of the pain was reflected in all the AVD. The principal limitation was the disability to enjoy the life. The peripheral neuropathy occupied the first place in order of subjective importance for the patient followed by the fatigue and the constipation.
  
  
  CONCLUSIONS
  A proper assessment and early detection of neuropathic pain is critical to minimizing its impact on the quality of life of patients.
authors.affiliation: Servicio de Hematología, Hospital Universitario Joan XXIII de Tarragona, Tarragona, España; Cátedra de Dolor Infantil URV-Fundación Grünenthal, Unidad para el Estudio y Tratamiento del Dolor-ALGOS, Tarragona, España; Centre de Recerca en Avaluació i Mesura del Comportament (CRAMC), Tarragona, España; Institut d'Investigació Sanitària Pere Virgili, Tarragona, España. Electronic address: soniaexposito@hotmail.es.
authors.forename: S
authors.initials: S
authors.lastname: Expósito Vizcaíno
authors.affiliation: Servicio de Neurología, Hospital Universitario Joan XXIII de Tarragona, Tarragona, España; Institut d'Investigació Sanitària Pere Virgili, Tarragona, España.
authors.forename: J
authors.initials: J
authors.lastname: Casanova-Mollà
authors.affiliation: Servicio de Hematología, Hospital Universitario Joan XXIII de Tarragona, Tarragona, España; Institut d'Investigació Sanitària Pere Virgili, Tarragona, España.
authors.forename: L
authors.initials: L
authors.lastname: Escoda
authors.affiliation: Cátedra de Dolor Infantil URV-Fundación Grünenthal, Unidad para el Estudio y Tratamiento del Dolor-ALGOS, Tarragona, España; Centre de Recerca en Avaluació i Mesura del Comportament (CRAMC), Tarragona, España; Departamento de Psicología, Universitat Rovira i Virgili, Tarragona, España; Institut d'Investigació Sanitària Pere Virgili, Tarragona, España.
authors.forename: S
authors.initials: S
authors.lastname: Galán
authors.affiliation: Cátedra de Dolor Infantil URV-Fundación Grünenthal, Unidad para el Estudio y Tratamiento del Dolor-ALGOS, Tarragona, España; Centre de Recerca en Avaluació i Mesura del Comportament (CRAMC), Tarragona, España; Departamento de Psicología, Universitat Rovira i Virgili, Tarragona, España; Institut d'Investigació Sanitària Pere Virgili, Tarragona, España.
authors.forename: J
authors.initials: J
authors.lastname: Miró
mesh_terms: D000203:Activities of Daily Living; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D000069286:Bortezomib / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000188:drug therapy*; D009437:Neuralgia / Q000188:drug therapy*; D013030:Spain
chemical_list: D000970:Antineoplastic Agents; D000069286:Bortezomib
keywords: Bortezomib; Detección precoz; Dolor; Early detection; Effects on Activities of daily living; Mieloma múltiple; Multiple myeloma; Neuropatía periférica; Pain; Peripheral neuropathy; Repercusiones en las Actividades de la vida diaria