title: ANTI-IL-2 Receptor Antibody Treatment for Lymphoproliferative Disease: Transient Response in A Case of Ki-1+ Anaplastic Large Cell Lymphoma.
abstract: Most cases of Ki-1 + anaplastic large cell lymphomas (ALCL) express the CD25 antigen, and we have recently shown that IL-2 producing cells can also be detected in these lymphomas. The latter cells may thus constitute targets for anti-CD25 Mab treatment. In one patient with a chemoresistant disseminated Ki-1 + ALCL such a therapeutic approach was undertaken. We report the dramatic antitumoral effect of anti-CD25 Mab obtained in this patient. This confirms the observation, previously reported in adult T cell leukemia, showing that this therapeutic regimen is also efficient in CD25 + solid tumors.
authors.affiliation: a INSERM U131 and Service de Médecine Interne.
authors.forename: D
authors.initials: D
authors.lastname: Emilie
authors.affiliation: c Service d'Anatomopathologie.
authors.forename: M
authors.initials: M
authors.lastname: Peuchmaur
authors.affiliation: b Laboratoire d'Hématologie, Hopital A. Béclère, Clamart, France.
authors.forename: P
authors.initials: P
authors.lastname: Solal-Celigny
authors.affiliation: a INSERM U131 and Service de Médecine Interne.
authors.forename: F
authors.initials: F
authors.lastname: Boue
authors.affiliation: a INSERM U131 and Service de Médecine Interne.
authors.forename: J F
authors.initials: JF
authors.lastname: Defraissy
authors.affiliation: a INSERM U131 and Service de Médecine Interne.
authors.forename: G
authors.initials: G
authors.lastname: Tertian
authors.affiliation: a INSERM U131 and Service de Médecine Interne.
authors.forename: J
authors.initials: J
authors.lastname: Dormont
authors.affiliation: a INSERM U131 and Service de Médecine Interne.
authors.forename: P
authors.initials: P
authors.lastname: Galanaud
keywords: Lymphoma; interleukin-2; interleukin-2 receptor; monoclonal antibody; paracrin growth