title: The "Fully Catalytic System" in Mitsunobu Reaction Has Not Been Realized Yet.
abstract: An investigation of the recently reported "fully catalytic Mitsunobu reaction" using catalytic amounts of a phosphine reagent and an azo reagent has shown that although benzyl 4-nitrobenzoate is formed under the fully catalytic conditions, the same result is obtained if the hydrazine catalyst is omitted, indicating that this is not a Mitsunobu reaction. In addition, when the reaction between (-)-ethyl lactate and 4-nitrobenzoic acid was carried out using the "fully catalytic" method, the corresponding ester was formed but in very low yield and with predominant retention of configuration. Unfortunately, the system catalytic in phosphine reagent is incompatible with that in the azo reagent.
authors.affiliation: Graduate School of Natural Science and Technology, Kanazawa University , Kakuma-machi, Kanazawa 920-1192, Japan.
authors.forename: Daisuke
authors.initials: D
authors.lastname: Hirose
authors.affiliation: Faculty of Chemistry and Chemical Technology, University of Ljubljana , Večna pot 113, SI-1000, Ljubljana, Slovenia.
authors.forename: Martin
authors.initials: M
authors.lastname: Gazvoda
authors.affiliation: Faculty of Chemistry and Chemical Technology, University of Ljubljana , Večna pot 113, SI-1000, Ljubljana, Slovenia.
authors.forename: Janez
authors.initials: J
authors.lastname: Košmrlj
authors.affiliation: School of Pharmaceutical Sciences, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University , Kakuma-machi, Kanazawa 920-1192, Japan.
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Taniguchi