title: A Genome-Wide Search for Greek and Jewish Admixture in the Kashmiri Population.
abstract: The Kashmiri population is an ethno-linguistic group that resides in the Kashmir Valley in northern India. A longstanding hypothesis is that this population derives ancestry from Jewish and/or Greek sources. There is historical and archaeological evidence of ancient Greek presence in India and Kashmir. Further, some historical accounts suggest ancient Hebrew ancestry as well. To date, it has not been determined whether signatures of Greek or Jewish admixture can be detected in the Kashmiri population. Using genome-wide genotyping and admixture detection methods, we determined there are no significant or substantial signs of Greek or Jewish admixture in modern-day Kashmiris. The ancestry of Kashmiri Tibetans was also determined, which showed signs of admixture with populations from northern India and west Eurasia. These results contribute to our understanding of the existing population structure in northern India and its surrounding geographical areas.
authors.affiliation: Department of Human Genetics, University of Utah School of Medicine, Salt Lake City, Utah, United States of America.
authors.forename: Jonathan M
authors.identifier: http://orcid.org/0000-0002-5424-4401
authors.initials: JM
authors.lastname: Downie
authors.affiliation: Division of Hematology and Hematologic Malignancies, Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City, Utah, United States of America.
authors.forename: Tsewang
authors.initials: T
authors.lastname: Tashi
authors.affiliation: Division of Hematology and Hematologic Malignancies, Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City, Utah, United States of America.
authors.forename: Felipe Ramos
authors.initials: FR
authors.lastname: Lorenzo
authors.affiliation: Department of Human Genetics, University of Utah School of Medicine, Salt Lake City, Utah, United States of America.
authors.forename: Julie Ellen
authors.initials: JE
authors.lastname: Feusier
authors.affiliation: Department of Internal & Pulmonary Medicine, Sher-i-Kashmir Institute of Medical Sciences, Srinagar, Jammu and Kashmir, India.
authors.forename: Hyder
authors.initials: H
authors.lastname: Mir
authors.affiliation: Division of Hematology and Hematologic Malignancies, Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City, Utah, United States of America.
authors.forename: Josef T
authors.initials: JT
authors.lastname: Prchal
authors.affiliation: Department of Human Genetics, University of Utah School of Medicine, Salt Lake City, Utah, United States of America.
authors.forename: Lynn B
authors.initials: LB
authors.lastname: Jorde
authors.affiliation: Department of Internal & Pulmonary Medicine, Sher-i-Kashmir Institute of Medical Sciences, Srinagar, Jammu and Kashmir, India.
authors.forename: Parvaiz A
authors.initials: PA
authors.lastname: Koul
mesh_terms: D004247:DNA / Q000737:chemistry / Q000302:isolation & purification / Q000378:metabolism; D005828:Genetics, Population; D055106:Genome-Wide Association Study; D005838:Genotype; D006115:Greece; D006801:Humans; D007194:India; D007585:Jews / Q000235:genetics*; D020411:Oligonucleotide Array Sequence Analysis; D020641:Polymorphism, Single Nucleotide; D025341:Principal Component Analysis; D044465:White People / Q000235:genetics*
chemical_list: D004247:DNA