title: Coupling of transient near infrared photonic with magnetic nanoparticle for potential dissipation-free biomedical application in brain.
abstract: Combined treatment strategies based on magnetic nanoparticles (MNPs) with near infrared ray (NIR) biophotonic possess tremendous potential for non-invasive therapeutic approach. Nonetheless, investigations in this direction have been limited to peripheral body region and little is known about the potential biomedical application of this approach for brain. Here we report that transient NIR exposure is dissipation-free and has no adverse effect on the viability and plasticity of major brain cells in the presence or absence superparamagnetic nanoparticles. The 808 nm NIR laser module with thermocouple was employed for functional studies upon NIR exposure to brain cells. Magnetic nanoparticles were characterized using transmission electron microscopy (TEM), X-ray diffraction (XRD), dynamic laser scattering (DLS), and vibrating sample magnetometer (VSM). Brain cells viability and plasticity were analyzed using electric cell-substrate impedance sensing system, cytotoxicity evaluation, and confocal microscopy. When efficacious non-invasive photobiomodulation and neuro-therapeutical targeting and monitoring to brain remain a formidable task, the discovery of this dissipation-free, transient NIR photonic approach for brain cells possesses remarkable potential to add new dimension.
authors.affiliation: Center for Personalized Nanomedicine/Institute of Neuroimmune Pharmacology, Department of Immunology, Herbert Wertheim College of Medicine, Florida International University, Miami, Florida 33199, USA.
authors.forename: Vidya
authors.initials: V
authors.lastname: Sagar
authors.affiliation: Center for Personalized Nanomedicine/Institute of Neuroimmune Pharmacology, Department of Immunology, Herbert Wertheim College of Medicine, Florida International University, Miami, Florida 33199, USA.
authors.forename: V S R
authors.initials: VSR
authors.lastname: Atluri
authors.affiliation: Center for Personalized Nanomedicine/Institute of Neuroimmune Pharmacology, Department of Immunology, Herbert Wertheim College of Medicine, Florida International University, Miami, Florida 33199, USA.
authors.forename: A
authors.initials: A
authors.lastname: Tomitaka
authors.affiliation: Department of Biomedical engineering, College of Engineering and Computing, Florida International University, Miami, 33174 Florida, USA.
authors.forename: P
authors.initials: P
authors.lastname: Shah
authors.affiliation: Department of Biomedical engineering, College of Engineering and Computing, Florida International University, Miami, 33174 Florida, USA.
authors.forename: A
authors.initials: A
authors.lastname: Nagasetti
authors.affiliation: Center for Personalized Nanomedicine/Institute of Neuroimmune Pharmacology, Department of Immunology, Herbert Wertheim College of Medicine, Florida International University, Miami, Florida 33199, USA.
authors.forename: S
authors.initials: S
authors.lastname: Pilakka-Kanthikeel
authors.affiliation: Center for Personalized Nanomedicine/Institute of Neuroimmune Pharmacology, Department of Immunology, Herbert Wertheim College of Medicine, Florida International University, Miami, Florida 33199, USA.
authors.forename: N
authors.initials: N
authors.lastname: El-Hage
authors.affiliation: Department of Biomedical engineering, College of Engineering and Computing, Florida International University, Miami, 33174 Florida, USA.
authors.forename: A
authors.initials: A
authors.lastname: McGoron
authors.affiliation: Department of Electrical and Computer Engineering, Yokohama National University, Yokohama 240-8501, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Takemura
authors.affiliation: Center for Personalized Nanomedicine/Institute of Neuroimmune Pharmacology, Department of Immunology, Herbert Wertheim College of Medicine, Florida International University, Miami, Florida 33199, USA.
authors.forename: M
authors.initials: M
authors.lastname: Nair
mesh_terms: D001253:Astrocytes / Q000187:drug effects; D001927:Brain Diseases / Q000628:therapy; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D004578:Electron Spin Resonance Spectroscopy; D006801:Humans; D058185:Magnetite Nanoparticles / Q000737:chemistry / Q000633:toxicity* / Q000648:ultrastructure; D010316:Particle Size; D013055:Spectrophotometry, Infrared
chemical_list: D058185:Magnetite Nanoparticles