title: [Relationship between sleep architecture and blood pressure dynamic change in patients with sleep apnea syndrome].
abstract: OBJECTIVE
  To investigate sleep architecture and blood pressure dynamic change in patients with Sleep apnea syndrome by electrocardiogram-based cardiopulmonary coupling analysis system.
  
  
  METHODS
  Seventy-nine sleep disorder participants (PSQI≥8) were enrolled. Electrocardiogram-based cardiopulmonary coupling analysis device and ambulatory blood pressure monitoring were synchronously used to evaluate sleep architecture and blood pressure circadian rhythm. The patients were divided into SAS group (47 participants) and non-SAS group (32 participants) according to the Apnea Hypopnea Index (AHI) that calculated by CPC device. The data of sleep architecture and blood pressure variability were compared between two groups.
  
  
  RESULTS
  Compared with non-SAS group, SAS group have less proportion of deep sleep, more proportion of light sleep, higher mean blood pressure in 24 hours and daytime, lower nocturnal blood pressure dipping, faster mean heart rate in night time (P<0.05). AHI has moderate inverse correlation with deep sleep time, wake/dream time (-0.6≤r<-0.3), moderate positive correlation with light sleep time (0.3<r≤0.6), high inverse correlation with nocturnal blood pressure dipping (r=-0.785, P=0.000), moderate positive correlation with mean diastolic blood pressure (r=0.425, P=0.019).
  
  
  CONCLUSIONS
  Our study shows that less proportion of deep sleep, more proportion of light sleep, 24 hours mean blood pressure and nocturnal blood pressure increase in the patients with Sleep Apnea Syndrome. The severity of Sleep Apnea Syndrome has a positive correlation with the severity of abnormal sleep architecture and the degree of blood pressure elevation.
authors.affiliation: Internation Medical Center, China-Japan Friendship Hospital, Beijing 100029, China.
authors.forename: Y Q
authors.initials: YQ
authors.lastname: Zhu
authors.forename: Q
authors.initials: Q
authors.lastname: Long
authors.forename: C
authors.initials: C
authors.lastname: Wang
authors.forename: X J
authors.initials: XJ
authors.lastname: Shuai
authors.forename: B
authors.initials: B
authors.lastname: Chen
authors.forename: J
authors.initials: J
authors.lastname: Kong
authors.forename: Y L
authors.initials: YL
authors.lastname: Wei
mesh_terms: D001794:Blood Pressure / Q000502:physiology*; D018660:Blood Pressure Monitoring, Ambulatory; D002940:Circadian Rhythm; D004562:Electrocardiography; D005260:Female; D006801:Humans; D008297:Male; D017286:Polysomnography; D012890:Sleep / Q000502:physiology; D012891:Sleep Apnea Syndromes / Q000503:physiopathology*; D012893:Sleep Wake Disorders / Q000503:physiopathology*