title: Role of bioactive fatty acids in nonalcoholic fatty liver disease.
abstract: Nonalcoholic fatty liver disease (NAFLD) is characterized by fat deposition in hepatocytes, and a strong association with nutritional factors. Dietary fatty acids are classified according to their biochemical properties, which confer their bioactive roles. Monounsaturated fatty acids have a dual role in various human and murine models. In contrast, polyunsaturated fatty acids exhibit antiobesity, anti steatosic and anti-inflammatory effects. The combination of these forms of fatty acids-according to dietary type, daily intake and the proportion of n-6 to n-3 fats-can compromise hepatic lipid metabolism. A chemosensory rather than a nutritional role makes bioactive fatty acids possible biomarkers for NAFLD. Bioactive fatty acids provide health benefits through modification of fatty acid composition and modulating the activity of liver cells during liver fibrosis. More and better evidence is necessary to elucidate the role of bioactive fatty acids in nutritional and clinical treatment strategies for patients with NAFLD.
authors.affiliation: Translational Research Unit, Medica Sur Clinic & Foundation, Puente de Piedra 150 Toriello Guerra, Tlalpan, ZC 14050, Mexico City, Mexico.
authors.forename: Eva
authors.initials: E
authors.lastname: Juárez-Hernández
authors.affiliation: Translational Research Unit, Medica Sur Clinic & Foundation, Puente de Piedra 150 Toriello Guerra, Tlalpan, ZC 14050, Mexico City, Mexico.
authors.forename: Norberto C
authors.initials: NC
authors.lastname: Chávez-Tapia
authors.affiliation: Translational Research Unit, Medica Sur Clinic & Foundation, Puente de Piedra 150 Toriello Guerra, Tlalpan, ZC 14050, Mexico City, Mexico.|Obesity and Digestive Diseases Unit, Medica Sur Clinic & Foundation, Mexico City, Mexico.
authors.forename: Misael
authors.initials: M
authors.lastname: Uribe
authors.affiliation: Translational Research Unit, Medica Sur Clinic & Foundation, Puente de Piedra 150 Toriello Guerra, Tlalpan, ZC 14050, Mexico City, Mexico. vbarberob@medicasur.org.mx.
authors.forename: Varenka J
authors.initials: VJ
authors.lastname: Barbero-Becerra
mesh_terms: D004032:Diet; D004041:Dietary Fats / Q000008:administration & dosage / Q000009:adverse effects / Q000145:classification; D005227:Fatty Acids / Q000008:administration & dosage / Q000145:classification / Q000502:physiology*; D005229:Fatty Acids, Monounsaturated; D015525:Fatty Acids, Omega-3; D043371:Fatty Acids, Omega-6; D005231:Fatty Acids, Unsaturated; D006801:Humans; D050356:Lipid Metabolism / Q000187:drug effects; D008099:Liver / Q000378:metabolism; D008103:Liver Cirrhosis; D065626:Non-alcoholic Fatty Liver Disease / Q000503:physiopathology*
chemical_list: D004041:Dietary Fats; D005227:Fatty Acids; D005229:Fatty Acids, Monounsaturated; D015525:Fatty Acids, Omega-3; D043371:Fatty Acids, Omega-6; D005231:Fatty Acids, Unsaturated
keywords: Fatty acids; Liver diseases; Nutrition; Risk factors