title: Efforts to eliminate the latent reservoir in resting CD4+ T cells: strategies for curing HIV-1 infection.
abstract: Since the introduction of the first antiretroviral drug, zidovudine, in 1987, over 25 different antiretroviral agents from six different drug classes have been approved for the treatment of HIV-1 infection. Today, combination antiretroviral therapy (ART) is extremely effective in suppressing HIV-1 replication, providing durable control of the virus in adherent patients. However, despite the effectiveness of ART in blocking viral replication, HIV-1 infection cannot be cured by ART alone because HIV-1 establishes a state of latent infection in a small pool of resting, memory CD4+ T cells. Some new developments in the search for a cure are discussed.
authors.affiliation: Johns Hopkins University School of Medicine , Baltimore , USA.
authors.forename: Ya-Chi
authors.initials: YC
authors.lastname: Ho
authors.affiliation: Johns Hopkins University School of Medicine , Baltimore , USA.
authors.forename: Janet D
authors.initials: JD
authors.lastname: Siliciano
keywords: HIV-1; cure; latent reservoir; memory CD4+ T cells; resting