title: Cyclin E as a potential therapeutic target in high grade serous ovarian cancer.
abstract: Cyclin E1 (CCNE1) gene amplification occurs in approximately 20% of ovarian high grade serous carcinoma (HGSC) and is associated with chemotherapy resistance and, in some studies, overall poor prognosis. The role of cyclin E1 in inducing S phase entry relies upon its interactions with cyclin dependent kinases (CDK), specifically CDK2. Therapies to target cyclin E1-related functions have centered on CDK inhibitors and proteasome inhibitors. While many studies have helped elucidate the functions and regulatory mechanisms of cyclin E1, further research utilizing cyclin E1 as a therapeutic target in ovarian cancer is warranted. This review serves to present the scientific background describing the role and function of cyclin E1 in cancer development and progression, to distinguish cyclin E1-amplified HGSC as a unique subset of ovarian cancer deserving of further therapeutic investigation, and to provide an updated overview on the studies which have utilized cyclin E1 as a target for therapy in ovarian cancer.
authors.affiliation: Women's Cancer Program, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
authors.forename: J
authors.initials: J
authors.lastname: Kanska
authors.affiliation: Women's Cancer Program, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
authors.forename: M
authors.initials: M
authors.lastname: Zakhour
authors.affiliation: Women's Cancer Program, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
authors.forename: B
authors.initials: B
authors.lastname: Taylor-Harding
authors.affiliation: Women's Cancer Program, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
authors.forename: B Y
authors.initials: BY
authors.lastname: Karlan
authors.affiliation: Women's Cancer Program, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA. Electronic address: wiedemeyerw@cshs.org.
authors.forename: W R
authors.initials: WR
authors.lastname: Wiedemeyer
mesh_terms: D019927:Cyclin E / Q000037:antagonists & inhibitors / Q000502:physiology*; D051357:Cyclin-Dependent Kinase 2 / Q000037:antagonists & inhibitors / Q000502:physiology; D018284:Cystadenocarcinoma, Serous / Q000209:etiology* / Q000628:therapy; D005260:Female; D006801:Humans; D015513:Oncogene Proteins / Q000037:antagonists & inhibitors / Q000502:physiology*; D010051:Ovarian Neoplasms / Q000209:etiology* / Q000628:therapy
chemical_list: C475820:CCNE1 protein, human; D019927:Cyclin E; D015513:Oncogene Proteins; C495894:CDK2 protein, human; D051357:Cyclin-Dependent Kinase 2
keywords: Cyclin E; High grade serous carcinoma; Ovarian cancer