title: Risk Factors of Lymph Nodes Metastases by Endometrial Cancer: A Retrospective One-center Study.
abstract: OBJECTIVE
  We aimed to identify the surgical-pathological risk factors separately for pelvic and para-aortic lymph nodes (LN) metastases in endometrial cancer (EC).
  
  
  METHODS
  The study cohort consisted of 179 patients with first diagnosis of EC, who were operated in our Institution between 2007 and 2014.
  
  
  RESULTS
  Pelvic and para-aortic LN dissection was performed in 115 patients (64.2%). The positive pelvic and para-aortic LN were diagnosed in 11.3% and 16.1% of cases, respectively. Patients with bad differentiated tumors (G3) showed about 5-times more risk to have affected LN. Deep infiltration of myometrium elevated the risk of pelvic LN infiltration 5 times and of para-aortic LN infiltration 14 times. G3, myometrial infiltration >50% and type II endometrial cancer correlated with a worse progression free survival (PFS) and overall survival (OS).
  
  
  CONCLUSIONS
  Tumor grade and deep myometrial invasion were the only significant predictors of pelvic and para-aortic lymph node metastases.
authors.affiliation: Department of Gynecology, Campus Virchow-Klinikum, Charité Medical University, Berlin, Germany Mustafa-Zelal.Muallem@charite.de.
authors.forename: Mustafa Zelal
authors.initials: MZ
authors.lastname: Muallem
authors.affiliation: Department of Gynecology, Campus Virchow-Klinikum, Charité Medical University, Berlin, Germany.
authors.forename: Jalid
authors.initials: J
authors.lastname: Sehouli
authors.affiliation: Department of Gynecology, Campus Virchow-Klinikum, Charité Medical University, Berlin, Germany.
authors.forename: Jumana
authors.initials: J
authors.lastname: Almuheimid
authors.affiliation: Department of Gynecology, Campus Virchow-Klinikum, Charité Medical University, Berlin, Germany.
authors.forename: Rolf
authors.initials: R
authors.lastname: Richter
authors.affiliation: Department for Obstetrics and Gynaecology, Julius-Maximilians-University Würzburg, School of Medicine, Würzburg, Germany.
authors.forename: Ralf
authors.initials: R
authors.lastname: Joukhadar
authors.affiliation: Department of Gynecology, Campus Virchow-Klinikum, Charité Medical University, Berlin, Germany.
authors.forename: Helmut
authors.initials: H
authors.lastname: Plett
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D018269:Carcinoma, Endometrioid / Q000473:pathology* / Q000601:surgery; D016889:Endometrial Neoplasms / Q000473:pathology* / Q000601:surgery; D005260:Female; D006801:Humans; D008197:Lymph Node Excision; D008198:Lymph Nodes / Q000473:pathology; D008207:Lymphatic Metastasis; D008875:Middle Aged; D011379:Prognosis; D012189:Retrospective Studies; D012307:Risk Factors; D047368:Tumor Burden
keywords: Risk factor; endometrial cancer; lymph node metastases