title: Silk Sericin-Functionalized Bacterial Cellulose as a Potential Wound-Healing Biomaterial.
abstract: Bacterial cellulose (BC) is a polysaccharide known as a suitable matrix for proper wound healing. To improve this ability, BC was functionalized with silk sericin (SS) that has cytoprotective and mitogenic effects. The composites obtained by solution impregnation were stabilized by hydrogen bonds, and SS could be released in a controlled manner. The constructs were highly porous with interconnected pores allowing for high water uptake that varied with the SS concentration used for sample preparation. While SS did not disrupt the stability of the BC network, soluble SS diffusing from the composites did not influence keratinocyte growth but enhanced fibroblast proliferation, which would further optimize the wound healing process and improve extracellular matrix production, accelerating healing. Further, improved cell viability was observed upon the composites. Because of their attractive structure and properties, these BC-SS biomaterials represent potential candidates not only for wound dressing applications but also for tissue engineering.
authors.affiliation: Department of Biomedical Engineering, College of Life Science and Technology, Huazhong University of Science and Technology , Wuhan 430074 People's Republic of China.
authors.forename: Lallepak
authors.initials: L
authors.lastname: Lamboni
authors.affiliation: Department of Chemistry Institute for Advanced Study, Division of Biomedical Engineering, Hong Kong University of Science and Technology , Clear Water Bay, Kowloon, Hong Kong, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Li
authors.affiliation: The Key Lab of Molecular Biophysics of MOE, College of Life Science and Technology, Huazhong University of Science and Technology , Wuhan 430074, China.
authors.forename: Jianfeng
authors.initials: J
authors.lastname: Liu
authors.affiliation: Department of Biomedical Engineering, College of Life Science and Technology, Huazhong University of Science and Technology , Wuhan 430074 People's Republic of China.
authors.forename: Guang
authors.initials: G
authors.lastname: Yang
mesh_terms: D001672:Biocompatible Materials / Q000737:chemistry / Q000494:pharmacology*; D049109:Cell Proliferation / Q000187:drug effects; D002478:Cells, Cultured; D002482:Cellulose / Q000737:chemistry / Q000494:pharmacology*; D005347:Fibroblasts / Q000166:cytology / Q000187:drug effects; D006801:Humans; D015603:Keratinocytes / Q000166:cytology / Q000187:drug effects; D011135:Polysaccharides, Bacterial / Q000737:chemistry / Q000494:pharmacology*; D047030:Sericins / Q000737:chemistry*; D047011:Silk / Q000737:chemistry*; D023822:Tissue Engineering; D014945:Wound Healing / Q000187:drug effects*
chemical_list: D001672:Biocompatible Materials; D011135:Polysaccharides, Bacterial; D047030:Sericins; D047011:Silk; D002482:Cellulose