title: Copper-catalyzed difluoromethylation of propargylamide-substituted indoles: synthesis of mono- and bis-difluoromethylated indoloazepinone derivatives.
abstract: A novel copper-catalyzed difluoromethylation of 2- or 3-propargylamide-substituted indoles with ICF2CO2Et via a radical cascade cyclization process is described. A wide substrate scope is compatible with the reaction conditions to synthesize mono- and bis-difluoromethylated indoloazepinone derivatives, which contain a seven-membered ring.
authors.affiliation: State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, China. liangym@lzu.edu.cn.
authors.forename: Hui-Liang
authors.initials: HL
authors.lastname: Hua
authors.affiliation: State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, China. liangym@lzu.edu.cn.
authors.forename: Bo-Sheng
authors.initials: BS
authors.lastname: Zhang
authors.affiliation: State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, China. liangym@lzu.edu.cn.
authors.forename: Yu-Tao
authors.initials: YT
authors.lastname: He
authors.affiliation: State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, China. liangym@lzu.edu.cn.
authors.forename: Yi-Feng
authors.initials: YF
authors.lastname: Qiu
authors.affiliation: State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, China. liangym@lzu.edu.cn.
authors.forename: Jing-Yuan
authors.initials: JY
authors.lastname: Hu
authors.affiliation: State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, China. liangym@lzu.edu.cn.
authors.forename: Yu-Chen
authors.initials: YC
authors.lastname: Yang
authors.affiliation: State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, China. liangym@lzu.edu.cn.
authors.forename: Yong-Min
authors.initials: YM
authors.lastname: Liang