title: SIRT1 and NAD+ precursors: Therapeutic targets in multiple sclerosis a review.
abstract: Neurodegeneration is an important determinant of disability in multiple sclerosis (MS) but while currently approved treatments reduce inflammation, they have not been shown to reduce neurodegeneration. SIRT1, a NAD dependent protein deacetylase, has been implicated in the pathogenesis of neurodegeneration in neurological diseases including MS. We have studied the role of SIRT1 in experimental autoimmune encephalomyelitis (EAE) and found evidence for a neuroprotective role. In this review we summarize the most recent findings from the use of SIRT1 activators and SIRT1 overexpression in transgenic mice. These data support provide a rational for the use of SIRT1 activators in MS.
authors.affiliation: Department of Neurology, University of Maryland, Baltimore, MD 21201, USA; Research Service, VA Maryland Health Care System, Baltimore, MD 21201, USA.
authors.forename: Vamshi K C
authors.initials: VK
authors.lastname: Nimmagadda
authors.affiliation: Department of Neurology, University of Maryland, Baltimore, MD 21201, USA; Research Service, VA Maryland Health Care System, Baltimore, MD 21201, USA; VA Multiple Sclerosis Center of Excellence East, Baltimore, MD 21201, USA.
authors.forename: Tapas K
authors.initials: TK
authors.lastname: Makar
authors.affiliation: Department of Neurology, University of Maryland, Baltimore, MD 21201, USA.
authors.forename: Krish
authors.initials: K
authors.lastname: Chandrasekaran
authors.affiliation: Department of Neurology, University of Maryland, Baltimore, MD 21201, USA.
authors.forename: Avinash Rao
authors.initials: AR
authors.lastname: Sagi
authors.affiliation: Department of Neurology, University of Maryland, Baltimore, MD 21201, USA.
authors.forename: Jayanta
authors.initials: J
authors.lastname: Ray
authors.affiliation: Department of Neurology, University of Maryland, Baltimore, MD 21201, USA; Research Service, VA Maryland Health Care System, Baltimore, MD 21201, USA.
authors.forename: James W
authors.initials: JW
authors.lastname: Russell
authors.affiliation: Department of Neurology, University of Maryland, Baltimore, MD 21201, USA; Research Service, VA Maryland Health Care System, Baltimore, MD 21201, USA; VA Multiple Sclerosis Center of Excellence East, Baltimore, MD 21201, USA. Electronic address: christopher.bever@va.gov.
authors.forename: Christopher T
authors.initials: CT
authors.lastname: Bever
mesh_terms: D000818:Animals; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000188:drug therapy / Q000378:metabolism; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D009103:Multiple Sclerosis / Q000188:drug therapy / Q000378:metabolism*; D009243:NAD / Q000096:biosynthesis*; D056564:Sirtuin 1 / Q000096:biosynthesis*
chemical_list: D007166:Immunosuppressive Agents; D009243:NAD; C447939:SIRT1 protein, human; D056564:Sirtuin 1
keywords: EAE; Multiple sclerosis; NAD; Neurodegeneration; SIRT1