title: The Safety of Ovarian Preservation in Early-Stage Adenocarcinoma Compared With Squamous Cell Carcinoma of Uterine Cervix: A Systematic Review and Meta-Analysis of Observational Studies.
abstract: The aim of this study was to compare the incidence of ovarian metastasis (OM) in adenocarcinoma (ADC) and squamous cell carcinoma (SCC) in early-stage cervical cancer and evaluate the safety of ovarian preservation in early-stage ADC.
  
  
  
  To perform a meta-analysis to compare the incidence of OM between early-stage ADC and SCC, we searched PubMed, EMBASE, and Cochrane for observational studies that compared it with pathological evidence after radical hysterectomy and oophorectomy. Odds ratios with 95% confidence intervals were calculated with a fixed effects model. We also found a few articles evaluating the oncological prognosis of patients with ovarian preservation to perform a systematic review.
  
  
  
  A total of 5 studies were included in the meta-analyses. The incidence of OM of patients with early-stage ADC and SCC were 2% and 0.4%, respectively (odds ratio, 5.27; 95% confidence interval, 2.14-13.45). In 1427 patients with ADC or SCC of the cervix FIGO stage (CIS-IIA) who underwent hysterectomy, no ovarian recurrences were observed after unilateral or bilateral ovarian preservation in ADC patients in the follow-up (30-68 months); however, 15 patients with SCC developed pelvic recurrence.
  
  
  
  Although the incidence of OM was higher in early-stage ADC than SCC according to ovarian pathology, it might be relatively safe to perform ovarian preservation with early-stage ADC because of low ovarian recurrence rate in short-term follow-ups.
authors.affiliation: Department of Obstetrics and Gynecology, Peking University First Hospital, Beijing, China.
authors.forename: Xiao-Bing
authors.initials: XB
authors.lastname: Jiao
authors.forename: Jun
authors.initials: J
authors.lastname: Hu
authors.forename: Li-Rong
authors.initials: LR
authors.lastname: Zhu
mesh_terms: D000230:Adenocarcinoma / Q000453:epidemiology* / Q000473:pathology / Q000556:secondary; D002294:Carcinoma, Squamous Cell / Q000453:epidemiology* / Q000473:pathology / Q000556:secondary; D005260:Female; D006801:Humans; D015994:Incidence; D009367:Neoplasm Staging; D064887:Observational Studies as Topic; D059351:Organ Sparing Treatments / Q000009:adverse effects / Q000379:methods / Q000706:statistics & numerical data*; D010051:Ovarian Neoplasms / Q000453:epidemiology* / Q000556:secondary*; D002583:Uterine Cervical Neoplasms / Q000453:epidemiology* / Q000473:pathology