title: Resveratrol affects DNA damage induced by ionizing radiation in human lymphocytes in vitro.
abstract: Resveratrol (3,4',5-trihydroxystilbene; RSV) acts on cancer cells in several ways, inducing cell cycle delay and apoptotic death, and enhancing ionizing radiation (IR)-mediated responses. However, fewer studies have examined RSV effects on normal cells. We have treated human lymphocytes in vitro with RSV, either alone or combined with IR, to evaluate its potential use as a radioprotector. We measured the effects of RSV on induction of DNA damage, repair kinetics, and modulation of histone deacetylase activity.
authors.affiliation: Dipartimento di Scienze, Università "Roma TRE", Roma, Italy.
authors.forename: Emiliano
authors.initials: E
authors.lastname: Basso
authors.affiliation: Dipartimento di Scienze, Università "Roma TRE", Roma, Italy.
authors.forename: Giulia
authors.initials: G
authors.lastname: Regazzo
authors.affiliation: Istituto di Biologia Molecolare e Patologia, CNR, Roma, Italy.
authors.forename: Mario
authors.initials: M
authors.lastname: Fiore
authors.affiliation: Sezione di Tossicologia e Scienze Biomediche, ENEA, Casaccia Roma, Italy.
authors.forename: Valentina
authors.initials: V
authors.lastname: Palma
authors.affiliation: Dipartimento di Scienze, Università "Roma TRE", Roma, Italy.
authors.forename: Gianandrea
authors.initials: G
authors.lastname: Traversi
authors.affiliation: Sezione di Tossicologia e Scienze Biomediche, ENEA, Casaccia Roma, Italy.
authors.forename: Antonella
authors.initials: A
authors.lastname: Testa
authors.affiliation: Istituto di Biologia Molecolare e Patologia, CNR, Roma, Italy.
authors.forename: Francesca
authors.initials: F
authors.lastname: Degrassi
authors.affiliation: Dipartimento di Scienze, Università "Roma TRE", Roma, Italy. Electronic address: renata.cozzi@uniroma3.it.
authors.forename: Renata
authors.initials: R
authors.lastname: Cozzi
mesh_terms: D017209:Apoptosis / Q000187:drug effects / Q000528:radiation effects; D002453:Cell Cycle / Q000187:drug effects / Q000528:radiation effects; D004249:DNA Damage / Q000187:drug effects / Q000528:radiation effects; D005434:Flow Cytometry; D006801:Humans; D008214:Lymphocytes / Q000187:drug effects / Q000528:radiation effects; D011839:Radiation, Ionizing; D000077185:Resveratrol; D013267:Stilbenes / Q000494:pharmacology*
chemical_list: D013267:Stilbenes; D000077185:Resveratrol
keywords: Ionizing radiations resveratrol dicentrics ƴH2AX DNA damage repair HDAC activity