title: Frameshift mutations, neoantigens and tumor-specific CD8(+) T cells in microsatellite unstable colorectal cancers.
abstract: Microsatellite unstable colorectal cancers (CRC) express frameshift mutation-derived tumor-specific neoantigens. We recently showed that: (i) frameshift mutations were correlated with tumor-infiltrating CD8(+) T cell density, (ii) neoantigen-specific cytotoxic T cells could be obtained in patients whose tumors harbored these mutations, underlining the interest of developing personalized immunotherapy strategies in these cancers.
authors.affiliation: Inserm U1079, Institute for Research and Innovation in Biomedecine (IRIB), Rouen, France; Inserm U872, Laboratory of Integrative Cancer Immunology, Paris, France; Université Paris Descartes, Paris, France; Cordeliers Research Center, Université Pierre et Marie Curie, Paris 6, Paris, France.
authors.forename: Pauline
authors.initials: P
authors.lastname: Maby
authors.affiliation: Inserm U872, Laboratory of Integrative Cancer Immunology, Paris, France; Université Paris Descartes, Paris, France; Cordeliers Research Center, Université Pierre et Marie Curie, Paris 6, Paris, France.
authors.forename: Jérôme
authors.initials: J
authors.lastname: Galon
authors.affiliation: Inserm U1079, Institute for Research and Innovation in Biomedecine (IRIB), Rouen, France; Department of Genetics, Rouen University Hospital, Rouen, France.
authors.forename: Jean-Baptiste
authors.initials: JB
authors.lastname: Latouche
keywords: Adoptive cell transfer; colorectal cancer; frameshift mutation; immunotherapy; microsatellite instablility; neoantigen; neopeptide; tumor-specific CD8+ T cell