title: [Hypertension, catecholamine hypersecretion and potential for metastasis: recent progress in the pathophysiology and genetics of pheochromocytoma and paraganglioma].
abstract: Pheochromocytomas and paragangliomas are catecholamine-secreting tumors usually associated with arterial hypertension. They can contribute to acute cardiovascular events. Ten to 15 percent of tumors are metastatic. Autosomal dominant gene alterations are present in more than a third of cases. The secretory phenotype and the risk of malignancy are driven by the presence of gene mutations, specifically in the subunits of succinate dehydrogenase. Recent advances in genomics have clinical implications for family screening, biological follow-up, prediction of the risk of recurrence, and therapeutic options in cases with malignant recurrence.
authors.forename: Pierre-François
authors.initials: PF
authors.lastname: Plouin
authors.forename: Laurence
authors.initials: L
authors.lastname: Amar
authors.forename: Anne-paule
authors.initials: AP
authors.lastname: Gimenez-Roqueplo
mesh_terms: D000310:Adrenal Gland Neoplasms / Q000150:complications / Q000378:metabolism* / Q000473:pathology / Q000503:physiopathology; D002395:Catecholamines / Q000378:metabolism; D006801:Humans; D006973:Hypertension / Q000209:etiology / Q000503:physiopathology; D009362:Neoplasm Metastasis; D010235:Paraganglioma / Q000235:genetics / Q000378:metabolism* / Q000503:physiopathology / Q000556:secondary; D010673:Pheochromocytoma / Q000150:complications / Q000235:genetics / Q000378:metabolism / Q000503:physiopathology / Q000556:secondary
chemical_list: D002395:Catecholamines