title: Dynamics of Metabolism and Decision Making During Alcohol Consumption: Modeling and Analysis.
abstract: Heavy alcohol consumption is considered an important public health issue in the United States as over 88 000 people die every year from alcohol-related causes. Research is being conducted to understand the etiology of alcohol consumption and to develop strategies to decrease high-risk consumption and its consequences, but there are still important gaps in determining the main factors that influence the consumption behaviors throughout the drinking event. There is a need for methodologies that allow us not only to identify such factors but also to have a comprehensive understanding of how they are connected and how they affect the dynamical evolution of a drinking event. In this paper, we use previous empirical findings from laboratory and field studies to build a mathematical model of the blood alcohol concentration dynamics in individuals that are in drinking events. We characterize these dynamics as the result of the interaction between a decision-making system and the metabolic process for alcohol. We provide a model of the metabolic process for arbitrary alcohol intake patterns and a characterization of the mechanisms that drive the decision-making process of a drinker during the drinking event. We use computational simulations and Lyapunov stability theory to analyze the effects of the parameters of the model on the blood alcohol concentration dynamics that are characterized. Also, we propose a methodology to inform the model using data collected in situ and to make estimations that provide additional information to the analysis. We show how this model allows us to analyze and predict previously observed behaviors, to design new approaches for the collection of data that improves the construction of the model, and help with the design of interventions.
authors.forename: Luis Felipe
authors.initials: LF
authors.lastname: Giraldo
authors.forename: Kevin M
authors.initials: KM
authors.lastname: Passino
authors.forename: John D
authors.initials: JD
authors.lastname: Clapp
authors.forename: Danielle
authors.initials: D
authors.lastname: Ruderman
mesh_terms: D000428:Alcohol Drinking / Q000097:blood / Q000453:epidemiology / Q000378:metabolism / Q000523:psychology; D000067401:Blood Alcohol Content; D003491:Cybernetics; D003657:Decision Making / Q000502:physiology*; D005246:Feedback; D006801:Humans; D015233:Models, Statistical; D012815:Signal Processing, Computer-Assisted
chemical_list: D000067401:Blood Alcohol Content