title: Association between CD14 SNP -159 C/T and gastric cancer: an independent case-control study and an updated meta-analysis.
abstract: OBJECTIVE
  The association between CD14 -159C/T polymorphism and the susceptibility to gastric cancer (GC) has been reported. However, the results were inconclusive. In the present study, a case-control study and a meta-analysis were performed to assess the possible association between -159C/T in the CD14 gene and GC risk.
  
  
  METHODS
  Relevant studies were searched in several databases including PubMed, Web of Science, EMBASE, Chinese National Knowledge Infrastructure database, and Wanfang database (last search was performed on December 30, 2015). In addition, a case-control study involving 164 GC cases and 169 controls was also performed in the analysis. Statistical analysis was performed by the software Revman5.3.
  
  
  RESULTS
  A total of ten published studies and the present case-control study involving 2,844 GC and 3,983 controls were included for the meta-analysis. The analysis result indicated that the T allele of CD14 -159C/T polymorphism did not confer risk for GC (in our study: [P=0.93]; in the meta-analysis: T vs 2N odds ratio =1.28 and 95% confidence interval (CI) =0.95-1.24, [P=0.24]). However, we found a significant association in the recessive model (in our study: TT vs TC+CC [P=0.04]; in the meta-analysis: TT vs TC+CC odds ratio =1.12 and 95% CI =1.01-1.26, [P=0.04]). Furthermore, a subgroup analysis by ethnicity showed that TT genotype was significantly associated with GC in Asian (odds ratio =1.17 and 95% CI =1.02-1.34, [P=0.02]) but not in Caucasian.
  
  
  CONCLUSIONS
  Our results highlight the TT genotype of CD14 -159C/T as a genetic susceptibility factor for gastric cancer, particularly, in Asians and population-based controls.
authors.affiliation: Department of Internal Medicine of Traditional Chinese Medicine, Hainan Medical University, Hainan; Department of Pathophysiology, Harbin Medical University, Harbin.
authors.forename: Ai-Min
authors.initials: AM
authors.lastname: Gong
authors.affiliation: Department of Pathophysiology, Harbin Medical University, Harbin.
authors.forename: Xin-Yuan
authors.initials: XY
authors.lastname: Li
authors.affiliation: Department of Internal Medicine of Traditional Chinese Medicine, Hainan Medical University, Hainan.
authors.forename: Yi-Qiang
authors.initials: YQ
authors.lastname: Xie
authors.affiliation: Department of Nephrology, Ningbo Tradition Chinese Medicine Hospital affiliated to Zhejiang Chinese Medical University, Ningbo.
authors.forename: Zhan-Dong
authors.initials: ZD
authors.lastname: Jia
authors.affiliation: The Fifth Department of Acupuncture.
authors.forename: Yuan-Xin
authors.initials: YX
authors.lastname: Li
authors.affiliation: Department of Nephrology, Jining Tradition Chinese Medicine Hospital, Jining, People's Republic of China.
authors.forename: Yong-Yan
authors.initials: YY
authors.lastname: Zou
authors.affiliation: Department of Pathophysiology, Harbin Medical University, Harbin.
authors.forename: Chang-Qing
authors.initials: CQ
authors.lastname: Xu
authors.affiliation: Department of Pathophysiology, Harbin Medical University, Harbin.
authors.forename: Zhen-Yu
authors.initials: ZY
authors.lastname: Wang
keywords: CD14; gastric cancer; meta-analysis; polymorphism