title: Effect of Temperature and Moisture on the Physical Stability of Binary and Ternary Amorphous Solid Dispersions of Celecoxib.
abstract: The effectiveness of different polymers, alone or in combination, in inhibiting the crystallization of celecoxib (CEX) from amorphous solid dispersions (ASDs) exposed to different temperatures and relative humidities was evaluated. It was found that polyvinylpyrrolidone (PVP) and PVP-vinyl acetate formed stronger or more extensive hydrogen bonding with CEX than cellulose-based polymers. This, combined with their better effectiveness in raising the glass transition temperature (Tg) of the dispersions, provided better physical stabilization of amorphous CEX against crystallization in the absence of moisture when compared with dispersions formed with cellulose derivatives. In ternary dispersions containing 2 polymers, the physical stability was minimally impaired by the presence of a cellulose-based polymer when the major polymer present was PVP. On exposure to moisture, stability of the CEX ASDs was strongly affected by both the dispersion hygroscopicity and the strength of the intermolecular interactions. Binary and ternary ASDs containing PVP appeared to undergo partial amorphous-amorphous phase separation when exposed 94% relative humidity, followed by crystallization, whereas other binary ASDs crystallized directly without amorphous-amorphous phase separation.
authors.affiliation: Department of Industrial and Physical Pharmacy, College of Pharmacy, Purdue University, West Lafayette, Indiana 47907.
authors.forename: Tian
authors.initials: T
authors.lastname: Xie
authors.affiliation: Department of Industrial and Physical Pharmacy, College of Pharmacy, Purdue University, West Lafayette, Indiana 47907. Electronic address: lstaylor@purdue.edu.
authors.forename: Lynne S
authors.initials: LS
authors.lastname: Taylor
mesh_terms: D000068579:Celecoxib / Q000737:chemistry*; D002482:Cellulose / Q000737:chemistry; D003460:Crystallization; D052246:Cyclooxygenase 2 Inhibitors / Q000737:chemistry*; D004355:Drug Stability; D005079:Excipients / Q000737:chemistry*; D006813:Humidity; D011145:Polyvinyls / Q000737:chemistry; D011205:Povidone / Q000737:chemistry; D013696:Temperature; D017155:Wettability
chemical_list: D052246:Cyclooxygenase 2 Inhibitors; D005079:Excipients; D011145:Polyvinyls; C036549:pioloform; D002482:Cellulose; D011205:Povidone; D000068579:Celecoxib
keywords: amorphous; crystallization; polymers; solubility; stabilization