title: Elevated nitric oxide levels associated with hepatic cell apoptosis during liver injury.
abstract: Hepatic injury is a major event in liver surgery such as liver transplantation and it always leads to hepatic cell apoptosis. Nitric oxide (NO) is a key signaling regulation molecule. Many researchers have shown that increased NO level can influence liver cell apoptosis by promoting or inhibiting the relative signaling pathways that are involved in the caspase family, Bax/Bcl-2, mitochondria, oxidative stress, death receptors, and mitogen-activated protein kinases. Elucidating the relationships between NO and hepatic cell apoptosis is necessary for ameliorating prognosis of liver surgery. This article reviews the newest research progress in the relationships between higher NO levels and hepatic cell apoptosis in liver injury.
authors.affiliation: Department of Physiology, College of Medicine, Nanchang University, Nanchang, China.
authors.forename: Hui
authors.identifier: http://orcid.org/0000-0002-1093-1509
authors.initials: H
authors.lastname: Liu
authors.affiliation: Department of Physiology, College of Medicine, Nanchang University, Nanchang, China.
authors.forename: Qian
authors.initials: Q
authors.lastname: Li
authors.affiliation: Department of Physiology, College of Medicine, Nanchang University, Nanchang, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Physiology, College of Medicine, Nanchang University, Nanchang, China.
authors.forename: Huimin
authors.initials: H
authors.lastname: Hong
authors.affiliation: Department of Physiology, College of Medicine, Nanchang University, Nanchang, China.
authors.forename: Mengting
authors.initials: M
authors.lastname: Chen
authors.affiliation: Department of Physiology, College of Medicine, Nanchang University, Nanchang, China.
authors.forename: Yingyi
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Experimental Teaching, Nanchang University, Nanchang, China.
authors.forename: Fenfang
authors.initials: F
authors.lastname: Hong
authors.affiliation: Department of Physiology, College of Medicine, Nanchang University, Nanchang, China.
authors.forename: Shulong
authors.initials: S
authors.lastname: Yang
keywords: apoptosis; hepatic injury; liver cell; nitric oxide