title: Longitudinal Alteration of Intrinsic Brain Activity in the Striatum in Mild Cognitive Impairment.
abstract: The striatum is a critical functional hub in understanding neurological disorders. However, the Alzheimer's disease (AD)-associated striatal change is unclear, as is the relationship between striatal change and AD pathology. Three-year resting-state fMRI data from 15 healthy control (HC) and 20 mild cognitive impairment (MCI) participants were obtained. We analyzed the amplitude of low-frequency fluctuations (ALFF) (0.01-0.08 Hz) and two subdivided bands (slow-4:0.027-0.073 Hz; slow-5:0.01-0.027 Hz). We calculated Aβ/pTau ratio using baseline cerebrospinal fluid pTau and Aβ1-42 to represent AD pathology. Compared to HC, MCI participants showed greater decline in right putaminal ALFF, including the slow-4 band. Greater decline of ALFF in the right putamen was significantly related to the memory decline over time and lower baseline Aβ/pTau ratio regardless of age or group. The slow-4 band, relative to slow-5 band, showed a stronger correlation between Aβ/pTau ratio and decline of ALFF in the right putamen. The results suggest that the putaminal function declines early in the AD-associated neurodegeneration. The continuous decline in putaminal ALFF, especially slow-4 band, may be a sensitive marker of AD pathology such as Aβ/pTau ratio regardless of clinical diagnosis.
authors.affiliation: School of Nursing, University of Rochester Medical Center, Rochester, NY, USA.
authors.forename: Ping
authors.initials: P
authors.lastname: Ren
authors.affiliation: Department of Neurology, Buddhist Tzu Chi General Hospital, Tzu Chi University, Hualien, Taiwan.
authors.forename: Raymond Y
authors.initials: RY
authors.lastname: Lo
authors.affiliation: Department of Psychiatry, University of Rochester Medical Center, Rochester, NY, USA.|Department of Public Health Sciences, University of Rochester Medical Center, Rochester, NY, USA.
authors.forename: Benjamin P
authors.initials: BP
authors.lastname: Chapman
authors.affiliation: Department of Neurology, University of California-Irvine, Irvine, CA, USA.
authors.forename: Mark
authors.initials: M
authors.lastname: Mapstone
authors.affiliation: Department of Psychiatry, University of Rochester Medical Center, Rochester, NY, USA.
authors.forename: Anton
authors.initials: A
authors.lastname: Porsteinsson
authors.affiliation: School of Nursing, University of Rochester Medical Center, Rochester, NY, USA.|Department of Psychiatry, University of Rochester Medical Center, Rochester, NY, USA.|Department of Brain and Cognitive Science, University of Rochester, Rochester, NY, USA.
authors.forename: Feng
authors.initials: F
authors.lastname: Lin
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D016229:Amyloid beta-Peptides / Q000134:cerebrospinal fluid; D001931:Brain Mapping; D060825:Cognitive Dysfunction / Q000503:physiopathology* / Q000523:psychology; D003342:Corpus Striatum / Q000503:physiopathology*; D018450:Disease Progression; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008137:Longitudinal Studies; D008279:Magnetic Resonance Imaging; D008297:Male; D008568:Memory / Q000502:physiology; D010446:Peptide Fragments / Q000134:cerebrospinal fluid; D012146:Rest; D016875:tau Proteins / Q000134:cerebrospinal fluid
chemical_list: D016229:Amyloid beta-Peptides; C054369:MAPT protein, human; D010446:Peptide Fragments; C075222:amyloid beta-protein (1-42); D016875:tau Proteins
keywords: Amyloid-beta; low-frequency fluctuation; mild cognitive impairment; pTau; resting state fMRI; striatum