title: Cu(II) doped polyaniline nanoshuttles for multimodal tumor diagnosis and therapy.
abstract: Nanodevices for multimodal tumor theranostics have shown great potentials for noninvasive tumor diagnosis and therapy, but the libraries of multimodal theranostic building blocks should be further stretched. In this work, Cu(II) ions are doped into polyaniline (Pani) nanoshuttles (NSs) to produce Cu-doped Pani (CuPani) NSs, which are demonstrated as new multimodal building blocks to perform tumor theranostics. The CuPani NSs are capable of shortening the longitudinal relaxation (T1) of protons under magnetic fields and can help light up tumors in T1-weighted magnetic resonance imaging. In addition, the released Cu(II) ions from CuPani NSs lead to cytotoxicity, showing the behavior of chemotherapeutic agent. The good photothermal performance of CuPani NSs also makes them as photothermal agents to perform thermochemotherapy. By combining near-infrared laser irradiation, a complete tumor ablation is achieved and no tumor recurrence is observed.
authors.affiliation: State Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University, Changchun 130012, PR China.
authors.forename: Min
authors.initials: M
authors.lastname: Lin
authors.affiliation: Department of Oral Pathology, School and Hospital of Stomatology, Jilin University, Changchun 130021, PR China.
authors.forename: Dandan
authors.initials: D
authors.lastname: Wang
authors.affiliation: State Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University, Changchun 130012, PR China.
authors.forename: Shuyao
authors.initials: S
authors.lastname: Li
authors.affiliation: Department of Oral Pathology, School and Hospital of Stomatology, Jilin University, Changchun 130021, PR China.
authors.forename: Qi
authors.initials: Q
authors.lastname: Tang
authors.affiliation: State Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University, Changchun 130012, PR China.
authors.forename: Shuwei
authors.initials: S
authors.lastname: Liu
authors.affiliation: State Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University, Changchun 130012, PR China.
authors.forename: Rui
authors.initials: R
authors.lastname: Ge
authors.affiliation: State Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University, Changchun 130012, PR China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Department of Thyroid Surgery, China-Japan Union Hospital, Jilin University, Changchun 130033, PR China. Electronic address: daqizhang@yeah.net.
authors.forename: Daqi
authors.initials: D
authors.lastname: Zhang
authors.affiliation: Department of Oral Pathology, School and Hospital of Stomatology, Jilin University, Changchun 130021, PR China. Electronic address: hcsun@mail.jlu.edu.cn.
authors.forename: Hongchen
authors.initials: H
authors.lastname: Sun
authors.affiliation: State Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University, Changchun 130012, PR China. Electronic address: hao_zhang@jlu.edu.cn.
authors.forename: Hao
authors.initials: H
authors.lastname: Zhang
authors.affiliation: State Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University, Changchun 130012, PR China.
authors.forename: Bai
authors.initials: B
authors.lastname: Yang
mesh_terms: D000814:Aniline Compounds / Q000737:chemistry*; D000818:Animals; D003287:Contrast Media / Q000737:chemistry; D003300:Copper / Q000737:chemistry / Q000627:therapeutic use*; D006367:HeLa Cells; D006801:Humans; D006979:Hyperthermia, Induced / Q000379:methods; D007259:Infrared Rays / Q000627:therapeutic use; D053685:Laser Therapy / Q000379:methods*; D053768:Metal Nanoparticles / Q000737:chemistry / Q000627:therapeutic use* / Q000648:ultrastructure; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D009374:Neoplasms, Experimental / Q000000981:diagnostic imaging* / Q000628:therapy*; D010789:Phototherapy / Q000379:methods; D000068936:Theranostic Nanomedicine / Q000379:methods*; D016896:Treatment Outcome
chemical_list: D000814:Aniline Compounds; D003287:Contrast Media; C416807:polyaniline; D003300:Copper
keywords: Magnetic resonance imaging; Nanoshuttles; Polyaniline; Theranostics; Thermochemotherapy