title: SYNTHESIS AND ANTIMICROBIAL PROPERTIES OF NEW MANDELATE IONIC LIQUIDS.
abstract: Novel mandelate ionic liquids with quartenary ammonium cations were synthesized and characterized. The compounds exhibit antimicrobial activity and the most potent one is of similar efficacy against Gram+ bacteria as its counterpart chloride. On the other hand, the mandelates are much less active against Gram-bacteria and fungi. QSAR models suggest that, with respect to cation, their potency depends on lipophilicity. The synthesized ionic liquids are also quite cytotoxic against mammalian cells.
authors.forename: Anna
authors.initials: A
authors.lastname: Wiśniewska
authors.forename: Piotr F J
authors.initials: PF
authors.lastname: Lipińsk
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Woźniak
authors.forename: Fabiola
authors.initials: F
authors.lastname: Sanjuan-Szklarz
authors.forename: Anna
authors.initials: A
authors.lastname: Cieniecka-Rosłonkiewicz
authors.forename: Alicja
authors.initials: A
authors.lastname: Michalczyk
authors.forename: Zbigniew
authors.initials: Z
authors.lastname: Dabrowski
authors.forename: Anna
authors.initials: A
authors.lastname: Kulig-Adamiak
authors.forename: Joanna
authors.initials: J
authors.lastname: Matalińska
authors.forename: Andrzej
authors.initials: A
authors.lastname: Leś
authors.forename: Jacek
authors.initials: J
authors.lastname: Cybulski
mesh_terms: D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D018360:Crystallography, X-Ray; D006094:Gram-Positive Bacteria / Q000187:drug effects; D052578:Ionic Liquids / Q000737:chemistry* / Q000494:pharmacology*; D008333:Mandelic Acids / Q000138:chemical synthesis* / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D021281:Quantitative Structure-Activity Relationship; D012996:Solutions
chemical_list: D000890:Anti-Infective Agents; D052578:Ionic Liquids; D008333:Mandelic Acids; D012996:Solutions