title: Polymorphisms in TCF7L2 gene are associated with gestational diabetes mellitus in Chinese Han population.
abstract: This study aimed to investigate the possible association between diabetes susceptibility gene transcription factor 7-like 2 (TCF7L2) and gestational diabetes mellitus (GDM) in a Chinese Han population. A total of 556 GDM patients and 500 Non-GDM were included. Eighteen single nucleotide polymorphisms (SNPs) were evaluated. Fifteen tag SNPs were selected from HapMap CHB database with a minor allele frequency of >0.2 and r(2) of >0.8. Three additional SNPs were also chosen because these SNPs are associated with type 2 diabetes in East Asians. TCF7L2 rs290487, rs6585194, and rs7094463 polymorphisms were found to be significantly associated with GDM. In multivariate analysis, rs290487 genetic variation (OR = 2.686 per each C allele, P = 0.002), pre-BMI > 24 kg/m(2) (OR = 1.592, P = 0.018), age > 25 years (OR = 1.780, P = 0.012) and LDL-C > 3.6 mmol/L (OR = 2.034, P = 0.009) were identified as independent risk factors of GDM, rs7094463 genetic variation (OR = 0.429 per each G allele, P = 0.005) was identified as independent protect factor of GDM. This finding suggests that TCF7L2 rs290487, and rs7094463 were a potential clinical value for the prediction of GDM.
authors.affiliation: Department of Endocrinology and Metabolism, the First Affiliated Hospital, College of Medicine, Zhejiang University, Zhejiang, China.
authors.forename: Dan
authors.initials: D
authors.lastname: Ye
authors.affiliation: Department of Metabolism and Endocrinology, People's Hospital of Fuyang City, Zhejiang Province, China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Fei
authors.affiliation: Key Lab of Combined Multi-Organ Transplantation, Ministry of Public Health, Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, the First Affiliated Hospital, College of Medicine, Zhejiang University, Zhejiang, China.
authors.forename: Qi
authors.initials: Q
authors.lastname: Ling
authors.affiliation: Department of Endocrinology and Metabolism, the First Affiliated Hospital, College of Medicine, Zhejiang University, Zhejiang, China.
authors.forename: Weiwei
authors.initials: W
authors.lastname: Xu
authors.affiliation: Department of Endocrinology and Metabolism, the First Affiliated Hospital, College of Medicine, Zhejiang University, Zhejiang, China.
authors.forename: Zhe
authors.initials: Z
authors.lastname: Zhang
authors.affiliation: Department of Reproductive Endocrinology, People's Hospital, Zhejiang Province, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Shu
authors.affiliation: Department of Endocrinology and Metabolism, the First Affiliated Hospital, College of Medicine, Zhejiang University, Zhejiang, China.
authors.forename: Chengjiang
authors.initials: C
authors.lastname: Li
authors.affiliation: Department of Endocrinology and Metabolism, the First Affiliated Hospital, College of Medicine, Zhejiang University, Zhejiang, China.
authors.forename: Fengqin
authors.initials: F
authors.lastname: Dong
mesh_terms: D044466:Asian People; D016640:Diabetes, Gestational / Q000235:genetics*; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D020641:Polymorphism, Single Nucleotide; D011247:Pregnancy; D058118:Transcription Factor 7-Like 2 Protein / Q000235:genetics*
chemical_list: C544894:TCF7L2 protein, human; D058118:Transcription Factor 7-Like 2 Protein