title: Clinically important difference of Stroke-Specific Quality of Life Scale for aneurysmal subarachnoid hemorrhage.
abstract: Health-related quality of life measurements, are commonly used to quantify burden of disease, to evaluate treatment method, and to facilitate benchmarking. The aim of the current study was to determine the Clinically Important Difference (CID) for a Chinese version of Stroke-specific Quality of Life (SS-QOL) in an aneurysmal subarachnoid hemorrhage (SAH) patient cohort. The study recruited SAH patients in a neurosurgical unit in Hong Kong. SAH patients who completed both 3-month and 1-year assessments were included in the analysis. The study received ethical approvals from the joint CUHK-NTEC Clinical Ethics Committee and written informed consent was obtained from all participants or their next of kins. Over a 2-year period, 65 eligible patients were included in the study. Employing the anchor-based approach with global rating of change, the CID estimate of SS-QOL total score was 4.7 (95% confidence interval [CI]: 2.5-5.3), the CID estimate for SSQOL physical subscore was 2.1 (95% CI: 0.3-2.4), and the CID estimate for SS-QOL psychosocial subscore change was 2.8 (95% CI: 1.8-3.7). In conclusion, our study defined the CID for SS-QOL applied to SAH patients and should be further validated in another SAH patient population.
authors.affiliation: Division of Neurosurgery, Department of Surgery, Prince of Wales Hospital, The Chinese University of Hong Kong, 30 Ngan Shing St, Sha Tin, New Territories, Hong Kong. Electronic address: georgewong@surgery.cuhk.edu.hk.
authors.forename: George K C
authors.initials: GK
authors.lastname: Wong
authors.affiliation: Division of Neurosurgery, Department of Surgery, Prince of Wales Hospital, The Chinese University of Hong Kong, 30 Ngan Shing St, Sha Tin, New Territories, Hong Kong.
authors.forename: Alex
authors.initials: A
authors.lastname: Lee
authors.affiliation: Division of Neurology, Prince of Wales Hospital, The Chinese University of Hong Kong, Sha Tin, New Territories, Hong Kong.
authors.forename: Adrian
authors.initials: A
authors.lastname: Wong
authors.affiliation: Division of Neurosurgery, Department of Surgery, Prince of Wales Hospital, The Chinese University of Hong Kong, 30 Ngan Shing St, Sha Tin, New Territories, Hong Kong.
authors.forename: Faith L H
authors.initials: FL
authors.lastname: Ho
authors.affiliation: Division of Neurosurgery, Department of Surgery, Prince of Wales Hospital, The Chinese University of Hong Kong, 30 Ngan Shing St, Sha Tin, New Territories, Hong Kong.
authors.forename: Sandy L Y
authors.initials: SL
authors.lastname: Leung
authors.affiliation: School of Public Health and Primary Care, Prince of Wales Hospital, The Chinese University of Hong Kong, Sha Tin, New Territories, Hong Kong.
authors.forename: Benny C Y
authors.initials: BC
authors.lastname: Zee
authors.affiliation: Division of Neurosurgery, Department of Surgery, Prince of Wales Hospital, The Chinese University of Hong Kong, 30 Ngan Shing St, Sha Tin, New Territories, Hong Kong.
authors.forename: Wai S
authors.initials: WS
authors.lastname: Poon
authors.affiliation: Department of Diagnostic Radiology, Kwong Wah Hospital, Hong Kong.
authors.forename: Deyond Y W
authors.initials: DY
authors.lastname: Siu
authors.affiliation: Department of Imaging and Interventional Radiology, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong.
authors.forename: Jill M
authors.initials: JM
authors.lastname: Abrigo
authors.affiliation: Division of Neurology, Prince of Wales Hospital, The Chinese University of Hong Kong, Sha Tin, New Territories, Hong Kong.
authors.forename: Vincent C T
authors.initials: VC
authors.lastname: Mok
mesh_terms: D000203:Activities of Daily Living; D000328:Adult; D000368:Aged; D017281:Cost of Illness; D018450:Disease Progression; D005260:Female; D006723:Hong Kong; D006801:Humans; D007802:Language; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D011788:Quality of Life; D020521:Stroke / Q000523:psychology*; D013345:Subarachnoid Hemorrhage / Q000523:psychology*; D016896:Treatment Outcome
keywords: Quality of life; Stroke; Subarachnoid hemorrhage