title: Antimuscarinics, β-3 Agonists, and Phosphodiesterase Inhibitors in the Treatment of Male Lower Urinary Tract Symptoms: An Evolving Paradigm.
abstract: It is increasingly recognized that the bladder is the originator of storage lower urinary tract symptoms, including overactive bladder in men. As these symptoms are most bothersome for patients, there has been an increasing interest in the evaluation of drug treatment to better target the bladder. Consequently, several new drug classes have been introduced to the therapeutic armamentarium. Antimuscarinics, which were previously avoided due to the concern regarding urinary retention, are now used in routine practice; however, their use is still hampered by discontinuation due to side effects.
authors.affiliation: Department of Urology, Royal Hallamshire Hospital, Glossop Road, Sheffield S10 2JF, UK.
authors.forename: Nadir I
authors.initials: NI
authors.lastname: Osman
authors.affiliation: Department of Urology, Royal Hallamshire Hospital, Glossop Road, Sheffield S10 2JF, UK; Department of Urology, University of Dammam, Bashar Ibn Burd Street, Khobar 31952, Kingdom of Saudi Arabia.
authors.forename: Reem
authors.initials: R
authors.lastname: Aldamanhori
authors.affiliation: Department of Urology, Royal Hallamshire Hospital, Glossop Road, Sheffield S10 2JF, UK.
authors.forename: Altaf
authors.initials: A
authors.lastname: Mangera
authors.affiliation: Department of Urology, Royal Hallamshire Hospital, Glossop Road, Sheffield S10 2JF, UK. Electronic address: c.r.chapple@sheffield.ac.uk.
authors.forename: Christopher R
authors.initials: CR
authors.lastname: Chapple
mesh_terms: D058667:Adrenergic beta-3 Receptor Agonists / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D006801:Humans; D059411:Lower Urinary Tract Symptoms / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology; D008297:Male; D018727:Muscarinic Antagonists / Q000627:therapeutic use*; D010726:Phosphodiesterase Inhibitors / Q000627:therapeutic use*; D011470:Prostatic Hyperplasia / Q000150:complications* / Q000188:drug therapy; D014563:Urodynamics / Q000187:drug effects*
chemical_list: D058667:Adrenergic beta-3 Receptor Agonists; D018727:Muscarinic Antagonists; D010726:Phosphodiesterase Inhibitors
keywords: Antimuscarinics; Lower urinary tract symptoms; Phosphodiesterase inhibitors; Storage LUTS; β-3 Agonists