title: Antioxidant, Anti-Inflammatory, and Antitumor Activities of Cultured Mycelia and Fruiting Bodies of the Elm Oyster Mushroom, Hypsizygus ulmarius (Agaricomycetes).
abstract: Ethanoic extracts from the fruiting bodies and mycelia of the elm oyster mushroom, Hypsizygus ulmarius, were evaluated for their antioxidant, anti-inflammatory, and antitumor properties. Ethnolic extracts of fruiting body and mycelia showed 88%, 85%, 71%, and 85%, 65%, 70% 2,2-diphenyl-1-picrylhydrazyl, hydroxyl (DPPH) and 2,2'-azinobis (3-ethyl benzothiazolin-6-sulfonic acid) (ABTS) radical-scavenging activities, respectively, at a concentration of 1000 µg/mL. The anti-inflammatory activity was determined using carrageenan- and formalin- induced paw edema models. Diclofenac was used as the standard drug. In both models, the mycelia extract showed higher activity than the fruiting body extract. The antitumor effect of the extracts against Dalton's Lymphoma Ascites cell-line-induced tumors showed significant antitumor activity. Mycochemical analysis confirmed the presence of many pharmacologically active compounds such as phenol, alkaloids, proteins, tannins, and polysaccharides. Among these, polysaccharides and phenolic compounds were present at a higher concentration in both extracts. These compounds might be largely responsible for the mushroom's medicinal properties. The results of this study indicate that H. ulmarius possesses significant antioxidant, anti-inflammatory, and antitumor properties.
authors.affiliation: Department of Microbiology, Amala Cancer Research Centre, Amala Nagar, Thrissur, India.
authors.forename: Panavalappil
authors.initials: P
authors.lastname: Greeshma
authors.affiliation: Department of Microbiology, Amala Cancer Research Centre, Amala Nagar, Thrissur, India.
authors.forename: Korattuvalappil S
authors.initials: KS
authors.lastname: Ravikumar
authors.affiliation: Department of Microbiology, St. Mary's College, Thrissur, India.
authors.forename: Mangalathmelathil N
authors.initials: MN
authors.lastname: Neethu
authors.affiliation: Indian Institute of Horticultural Research, Bangalore, India.
authors.forename: Meera
authors.initials: M
authors.lastname: Pandey
authors.affiliation: Department of Life Sciences, University of Calicut, Thenjipalam, Malappuram, India.
authors.forename: Karattuthodi Fathimathu
authors.initials: KF
authors.lastname: Zuhara
authors.affiliation: Department of Microbiology, Amala Cancer Research Centre, Amala Nagar, Thrissur 680 555, Kerala, India.
authors.forename: Kainoor K
authors.initials: KK
authors.lastname: Janardhanan
mesh_terms: D000363:Agaricales / Q000737:chemistry*; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000494:pharmacology*; D000975:Antioxidants / Q000494:pharmacology*; D052160:Benzothiazoles; D001713:Biphenyl Compounds; D045424:Complex Mixtures / Q000494:pharmacology*; D004008:Diclofenac / Q000494:pharmacology; D004195:Disease Models, Animal; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy*; D048690:Fruiting Bodies, Fungal / Q000737:chemistry; D008297:Male; D051379:Mice; D025282:Mycelium / Q000737:chemistry; D010851:Picrates; D013451:Sulfonic Acids
chemical_list: D000893:Anti-Inflammatory Agents; D000970:Antineoplastic Agents; D000975:Antioxidants; D052160:Benzothiazoles; D001713:Biphenyl Compounds; D045424:Complex Mixtures; D010851:Picrates; D013451:Sulfonic Acids; D004008:Diclofenac; C002502:2,2'-azino-di-(3-ethylbenzothiazoline)-6-sulfonic acid; C004931:1,1-diphenyl-2-picrylhydrazyl