title: Endocrine-specific NIR fluorophores for adrenal gland targeting.
abstract: The adrenal glands (AGs) are relatively small yet require definitive identification during their resection, or more commonly their avoidance. To enable image-guided surgery involving the AGs, we have developed novel near-infrared (NIR) fluorophores that target the AGs after a single intravenous injection, which provided dual-NIR image-guided resection or avoidance of the AGs during both open and minimally-invasive surgery.
authors.affiliation: Division of Hematology/Oncology, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA and Department of Gastroenterological Surgery II, Hokkaido University Graduate School of Medicine, Sapporo 060-8638, Japan.
authors.forename: Yoshitomo
authors.initials: Y
authors.lastname: Ashitate
authors.affiliation: Department of Chemistry, Georgia State University, Atlanta, GA 30303, USA. mhenary1@gsu.edu.
authors.forename: Andrew
authors.initials: A
authors.lastname: Levitz
authors.affiliation: Division of Hematology/Oncology, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA and Department of Surgery, Chonnam National University Medical School, Gwangju 501-746, South Korea.
authors.forename: Min Ho
authors.initials: MH
authors.lastname: Park
authors.affiliation: Division of Hematology/Oncology, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA and Department of Biomedical Sciences, Chonnam National University Medical School, Gwangju 501-746, South Korea.
authors.forename: Hoon
authors.initials: H
authors.lastname: Hyun
authors.affiliation: Division of Hematology/Oncology, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA.
authors.forename: Vivek
authors.initials: V
authors.lastname: Venugopal
authors.affiliation: Division of Hematology/Oncology, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA and Gordon Center for Medical Imaging, Division of Nuclear Medicine and Molecular Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA. hchoi12@mgh.harvard.edu.
authors.forename: GwangLi
authors.initials: G
authors.lastname: Park
authors.affiliation: Gordon Center for Medical Imaging, Division of Nuclear Medicine and Molecular Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA. hchoi12@mgh.harvard.edu.
authors.forename: Georges
authors.initials: G
authors.lastname: El Fakhri
authors.affiliation: Department of Chemistry, Georgia State University, Atlanta, GA 30303, USA. mhenary1@gsu.edu.
authors.forename: Maged
authors.initials: M
authors.lastname: Henary
authors.affiliation: Division of Hematology/Oncology, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA and ICube Laboratory, University of Strasbourg, Illkirch cedex 67412, France.
authors.forename: Sylvain
authors.initials: S
authors.lastname: Gioux
authors.affiliation: Division of Hematology/Oncology, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA and Curadel, LLC, 377 Plantation Street, Worcester, MA 01605, USA.
authors.forename: John V
authors.initials: JV
authors.lastname: Frangioni
authors.affiliation: Division of Hematology/Oncology, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA and Gordon Center for Medical Imaging, Division of Nuclear Medicine and Molecular Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA. hchoi12@mgh.harvard.edu.
authors.forename: Hak Soo
authors.initials: HS
authors.lastname: Choi
mesh_terms: D000311:Adrenal Glands / Q000601:surgery*; D005456:Fluorescent Dyes / Q000008:administration & dosage / Q000737:chemistry*; D006801:Humans; D007259:Infrared Rays; D007275:Injections, Intravenous; D025321:Surgery, Computer-Assisted
chemical_list: D005456:Fluorescent Dyes