title: A pioneer experience in Malaysia on In-house Radio-labelling of (131)I-rituximab in the treatment of Non-Hodgkin's Lymphoma and a case report of high dose (131)I-rituximab-BEAM conditioning autologous transplant.
abstract: Radioimmunotherapy is an established treatment modality in Non-Hodgkin's lymphoma. The only two commercially available radioimmunotherapies - (90)Y-ibritumomab tiuxetan is expensive and (131)I-tositumomab has been discontinued from commercial production. In resource limited environment, self-labelling (131)I-rituximab might be the only viable practical option. We reported our pioneer experience in Malaysia on self-labelling (131)I-rituximab, substituting autologous haematopoietic stem cell transplantation (HSCT) and a patient, the first reported case, received high dose (131)I-rituximab (6000MBq/163mCi) combined with BEAM conditioning for autologous HSCT.
authors.affiliation: Department of Medicine, Faculty of Medicine and Health Sciences, Universiti Malaysia Sarawak, Kota Samarahan, Sarawak, 94300 Malaysia. Electronic address: kuanjewwin@gmail.com.
authors.forename: Jew Win
authors.initials: JW
authors.lastname: Kuan
authors.affiliation: Department of Nuclear Medicine, Sarawak General Hospital, Jalan Hospital, Kuching, Sarawak, 93586 Malaysia. Electronic address: jameslawcs@yahoo.com.
authors.forename: Chiong Soon
authors.initials: CS
authors.lastname: Law
authors.affiliation: Sterile Production Section, Department of Pharmacy, Sarawak General Hospital, Jalan Hospital, Kuching, Sarawak, 93586 Malaysia. Electronic address: xiangqiwong@yahoo.com.
authors.forename: Xiang Qi
authors.initials: XQ
authors.lastname: Wong
authors.affiliation: Sterile Production Section, Department of Pharmacy, Sarawak General Hospital, Jalan Hospital, Kuching, Sarawak, 93586 Malaysia. Electronic address: david_koct@yahoo.co.uk.
authors.forename: Ching Tiong
authors.initials: CT
authors.lastname: Ko
authors.affiliation: Department of Nuclear Medicine, Sarawak General Hospital, Jalan Hospital, Kuching, Sarawak, 93586 Malaysia. Electronic address: zoolhilmi_75@hotmail.com.
authors.forename: Zool Hilmi
authors.initials: ZH
authors.lastname: Awang
authors.affiliation: Haemotology Unit, Department of Medicine, Sarawak General Hospital, Jalan Hospital, Kuching, Sarawak, 93586 Malaysia. Electronic address: leepingc@gmail.com.
authors.forename: Lee Ping
authors.initials: LP
authors.lastname: Chew
authors.affiliation: Department of Haematology, Ampang Hospital, Jalan Mewah Utara, Pandan Mewah, Ampang, Selangor, 68000 Malaysia. Electronic address: drchangkm@gmail.com.
authors.forename: Kian Meng
authors.initials: KM
authors.lastname: Chang
mesh_terms: D000328:Adult; D058846:Antibodies, Monoclonal, Murine-Derived; D018380:Hematopoietic Stem Cell Transplantation / Q000379:methods*; D006801:Humans; D007553:Isotope Labeling; D008228:Lymphoma, Non-Hodgkin / Q000473:pathology* / Q000628:therapy*; D008296:Malaysia; D008875:Middle Aged; D010865:Pilot Projects; D016499:Radioimmunotherapy / Q000379:methods; D019275:Radiopharmaceuticals; D011879:Radiotherapy Dosage; D000069283:Rituximab; D016896:Treatment Outcome
chemical_list: D058846:Antibodies, Monoclonal, Murine-Derived; D019275:Radiopharmaceuticals; D000069283:Rituximab; C507388:131I-rituximab
keywords: (131)I-rituximab; Iodine-131; Non-Hodgkin's lymphoma; Radioimmunotherapy; Rituximab