title: Powdered Wound Dressing Materials Made from wild Silkworm Antheraea pernyi Silk Fibroin on Full-skin Thickness Burn Wounds on Rats.
abstract: OBJECTIVE
  This study evaluated powdered burn wound dressing materials from wild silkworm fibroin in an animal model.
  
  
  METHODS
  Fifteen rats were used in this experiment. Full-thickness 2×2 cm burn wounds were created on the back of rats under anesthesia. In the two experimental groups, the wounds were treated with two different dressing materials made from silkworm fibroin. In the Control Group, natural healing without any dressing material was set as control. The wound surface area was measured at five days, seven days and 14 days. Wound healing was evaluated by histologic analysis.
  
  
  RESULTS
  By gross observation, there were no infections or severe inflammations through 14 days post-injury. The differences among groups were statistically significant at seven days and 14 days, postoperatively (P <0.037 and 0.001, respectively). By post hoc test, the defect size was significantly smaller in experimental Group 1 compared with the Control Group and experimental Group 2 at seven days postoperatively (P =0.022 and 0.029, respectively). The difference between Group 1 and Group 2 was statistically significant at 14 days postoperatively (P <0.001). Group 1 and control also differed significantly (P =0.002). Group 1 showed a smaller residual scar than the Control Group and Group 2 at 14 days post-injury. Histologic analysis showed more re-epithelization in Groups 1 and 2 than in the Control Groups.
  
  
  CONCLUSIONS
  Burn wound healing was accelerated with silk fibroin spun by wild silkworm Antheraea pernyi. There was no atypical inflammation with silk dressing materials. In conclusion, silk dressing materials can be used for treatment of burn wound.
authors.affiliation: Department of Oral and Maxillofacial Surgery, College of Dentistry, Gangneung Wonju National University.
authors.forename: Min-Keun
authors.initials: MK
authors.lastname: Kim
authors.affiliation: Department of Oral Anatomy, College of Dentistry and Research Institute of Oral Science, Gangneung-Wonju National University.
authors.forename: Ki-Yeon
authors.initials: KY
authors.lastname: Yoo
authors.affiliation: Department of Oral and Maxillofacial Surgery, College of Dentistry, Gangneung Wonju National University.
authors.forename: Kwang-Jun
authors.initials: KJ
authors.lastname: Kwon
authors.affiliation: Department of Oral and Maxillofacial Surgery, College of Dentistry, Gangneung Wonju National University.
authors.forename: Seong-Gon
authors.initials: SG
authors.lastname: Kim
authors.affiliation: Department of Oral and Maxillofacial Surgery, College of Dentistry, Gangneung Wonju National University.
authors.forename: Young-Wook
authors.initials: YW
authors.lastname: Park
authors.affiliation: Sericultural & Apicultural Materials Division, National Academy of Agricultural Science, Rural Development Administration.
authors.forename: Kwang-Gill
authors.initials: KG
authors.lastname: Lee
authors.affiliation: Sericultural & Apicultural Materials Division, National Academy of Agricultural Science, Rural Development Administration.
authors.forename: You-Young
authors.initials: YY
authors.lastname: Jo
authors.affiliation: Sericultural & Apicultural Materials Division, National Academy of Agricultural Science, Rural Development Administration.
authors.forename: Hae-Yong
authors.initials: HY
authors.lastname: Kweon
keywords: Antheraea pernyi; Full thickness burn wound; Rats; Silk fibroin; Wound dressing