title: Regulation of B cell functions by Toll-like receptors and complement.
abstract: B cell functions triggered by the clonally-rearranged antigen-specific B cell receptor (BCR) are regulated by several germ-line encoded receptors - including Toll-like receptors (TLRs) and complement receptors (CRs). Simultaneous or sequential engagement of these structures expressed either on the cell membrane or intracellularly, may fundamentally alter and fine tune activation, antibody and cytokine production of B cells. Here we review the expression and function of TLRs and various C3 fragment binding CRs on B cells, emphasizing their role in different human B cell subsets under physiological and pathological conditions. Studies underlining the importance of the crosstalk between TLRs and CRs in regulating B cell functions are also highlighted.
authors.affiliation: MTA-ELTE Immunology Research Group, Budapest, Eötvös Loránd University, Pázmány Péter s. 1/C, Budapest H-1117, Hungary.
authors.forename: Mariann
authors.initials: M
authors.lastname: Kremlitzka
authors.affiliation: Department of Immunology, Eötvös Loránd University, Pázmány Péter s. 1/C, Budapest H-1117, Hungary.
authors.forename: Bernadett
authors.initials: B
authors.lastname: Mácsik-Valent
authors.affiliation: MTA-ELTE Immunology Research Group, Budapest, Eötvös Loránd University, Pázmány Péter s. 1/C, Budapest H-1117, Hungary; Department of Immunology, Eötvös Loránd University, Pázmány Péter s. 1/C, Budapest H-1117, Hungary. Electronic address: anna.erdei@freemail.hu.
authors.forename: Anna
authors.initials: A
authors.lastname: Erdei
mesh_terms: D000818:Animals; D015551:Autoimmunity; D001402:B-Lymphocytes / Q000276:immunology* / Q000378:metabolism*; D003165:Complement System Proteins / Q000276:immunology* / Q000378:metabolism*; D004198:Disease Susceptibility; D005786:Gene Expression Regulation; D006801:Humans; D007113:Immunity, Innate; D056747:Immunomodulation; D011485:Protein Binding; D011951:Receptors, Complement / Q000378:metabolism; D015398:Signal Transduction; D051193:Toll-Like Receptors / Q000378:metabolism*
chemical_list: D011951:Receptors, Complement; D051193:Toll-Like Receptors; D003165:Complement System Proteins
keywords: B cells; Complement system; Crosstalk; TLR