title: Fermentative production of high titer gluconic and xylonic acids from corn stover feedstock by Gluconobacter oxydans and techno-economic analysis.
abstract: High titer gluconic acid and xylonic acid were simultaneously fermented by Gluconobacter oxydans DSM 2003 using corn stover feedstock after dry dilute sulfuric acid pretreatment, biodetoxification and high solids content hydrolysis. Maximum sodium gluconate and xylonate were produced at the titer of 132.46g/L and 38.86g/L with the overall yield of 97.12% from glucose and 90.02% from xylose, respectively. The drawbacks of filamentous fungus Aspergillus niger including weak inhibitor tolerance, large pellet formation and no xylose utilization were solved by using the bacterium strain G. oxydans. The obtained sodium gluconate/xylonate product was highly competitive as cement retarder additive to the commercial product from corn feedstock. The techno-economic analysis (TEA) based on the Aspen Plus modeling was performed and the minimum sodium gluconate/xylonate product selling price (MGSP) was calculated as $0.404/kg. This study provided a practical and economic competitive process of lignocellulose utilization for production of value-added biobased chemicals.
authors.affiliation: State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, China.
authors.forename: Hongsen
authors.initials: H
authors.lastname: Zhang
authors.affiliation: State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, China.
authors.forename: Gang
authors.initials: G
authors.lastname: Liu
authors.affiliation: State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, China.
authors.forename: Jian
authors.initials: J
authors.lastname: Zhang
authors.affiliation: State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, China. Electronic address: jbao@ecust.edu.cn.
authors.forename: Jie
authors.initials: J
authors.lastname: Bao
mesh_terms: D018533:Biomass; D003365:Costs and Cost Analysis; D005285:Fermentation; D005942:Gluconates / Q000378:metabolism*; D020600:Gluconobacter oxydans / Q000378:metabolism*; D005947:Glucose / Q000378:metabolism; D008031:Lignin / Q000737:chemistry / Q000378:metabolism*; D010072:Oxamic Acid / Q000031:analogs & derivatives* / Q000378:metabolism; D013464:Sulfuric Acids / Q000737:chemistry; D014994:Xylose / Q000378:metabolism; D003313:Zea mays
chemical_list: D005942:Gluconates; D013464:Sulfuric Acids; C036909:lignocellulose; D008031:Lignin; D014994:Xylose; D005947:Glucose; C033158:sulfuric acid; D010072:Oxamic Acid; C030691:gluconic acid
keywords: Aspen Plus modeling; Gluconate; Gluconobacter oxydans DSM 2003; Lignocellulose; Xylonate