title: Treatment of periodontal intrabony defects using autologous platelet-rich fibrin and titanium platelet-rich fibrin: a randomized, clinical, comparative study.
abstract: OBJECTIVE
  The aim of the present study was to compare the effectiveness of open flap debridement (OFD) alone and OFD with either autologous platelet-rich fibrin (PRF) or titanium PRF (TPRF) in the treatment of intrabony defects (IBD).
  
  
  METHODS
  The study was conducted on patients reporting to the Department of Periodontics, The Oxford Dental College and Hospital, Bangalore, India. Thirty-eight patients with 90 periodontal IBD of moderate-severe periodontitis were selected and assigned to the OFD alone group (group I), the OFD with autologous PRF group (group II), or the OFD with TPRF group (group III). In each patient, a minimum number of two sextants were present, with probing pocket depths (PPD) ≥5 mm in at least three teeth.
  
  
  RESULTS
  At 9 months' postoperatively, upon comparing the PPD reduction, defect depth reduction, and clinical attachment level gains, it was noted that groups II and III showed statistically-significant improvements compared with group I, but no statistically-significant difference was noted between groups II and III.
  
  
  CONCLUSIONS
  The present study demonstrated that marked improvements in the clinical parameters and radiographic outcomes were noted with both autologous PRF and TPRF in the treatment of IBD.
authors.affiliation: Department of Periodontics, The Oxford Dental College & Hospital, Bangalore, Karnataka, India.
authors.forename: Anirban
authors.initials: A
authors.lastname: Chatterjee
authors.affiliation: Department of Periodontology, Government Dental College and Research Institute, Bangalore, Karnataka, India.
authors.forename: Avani R
authors.initials: AR
authors.lastname: Pradeep
authors.affiliation: Department of Periodontology, Government Dental College and Research Institute, Bangalore, Karnataka, India.
authors.forename: Vibhuti
authors.initials: V
authors.lastname: Garg
authors.affiliation: Department of Periodontics, The Oxford Dental College & Hospital, Bangalore, Karnataka, India.
authors.forename: Shravanthi
authors.initials: S
authors.lastname: Yajamanya
authors.affiliation: Department of Periodontics, The Oxford Dental College & Hospital, Bangalore, Karnataka, India.
authors.forename: Mohammed M
authors.initials: MM
authors.lastname: Ali
authors.affiliation: Department of Periodontics, The Oxford Dental College & Hospital, Bangalore, Karnataka, India.
authors.forename: V Sneha
authors.initials: VS
authors.lastname: Priya
mesh_terms: D016301:Alveolar Bone Loss / Q000209:etiology / Q000628:therapy*; D055113:Chronic Periodontitis; D006801:Humans; D007194:India; D000073183:Platelet-Rich Fibrin; D014025:Titanium
chemical_list: D014025:Titanium
keywords: growth factor; periodontal regeneration; periodontitis