title: AdipoScan: A Novel Transient Elastography-Based Tool Used to Non-Invasively Assess Subcutaneous Adipose Tissue Shear Wave Speed in Obesity.
abstract: We describe a novel device called the AdipoScan that was adapted from the FibroScan to specifically assess shear wave speed (SWS) in human abdominal subcutaneous adipose tissue (scAT). Measurement reproducibility was assessed on tissue-mimicking phantoms with and without repositioning, with resultant coefficients of variation of 1% and 0%, respectively, as well as in vivo (14% and 7%, respectively). The applicability of the AdipoScan was tested on 19 non-obese volunteers, and a scAT thickness >2 cm was found to be mandatory to perform a valid measurement. Abdominal scAT SWS was assessed in 73 severely obese subjects, all candidates for bariatric surgery. Subcutaneous AT SWS was positively associated with scAT fibrosis and obesity-related co-morbidities such as hypertension, glycemic status, dyslipidemia and liver dysfunction. These results suggest that the AdipoScan could be a useful non-invasive tool to evaluate scAT fibrosis and metabolic complications in obesity. Further investigation is required to evaluate the relevance of using the AdipoScan to predict patient weight trajectories and metabolic outcomes after bariatric surgery.
authors.affiliation: R&D Department, Echosens, Paris, France. Electronic address: magali.sasso@echosens.com.
authors.forename: Magali
authors.initials: M
authors.lastname: Sasso
authors.affiliation: R&D Department, Echosens, Paris, France; Institute of Cardiometabolism and Nutrition, ICAN, UMR INSERM/UPMC 1166, Nutrition Department, Pitié-Salpêtrière Hospital, Paris, France.
authors.forename: Yuejun
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Institute of Cardiometabolism and Nutrition, ICAN, UMR INSERM/UPMC 1166, Nutrition Department, Pitié-Salpêtrière Hospital, Paris, France.
authors.forename: Judith
authors.initials: J
authors.lastname: Aron-Wisnewsky
authors.affiliation: Department of General, Digestive and Metabolic Surgery, Assistance Publique-Hôpitaux de Paris, Ambroise Paré Teaching Hospital, Boulogne, France.
authors.forename: Jean-Luc
authors.initials: JL
authors.lastname: Bouillot
authors.affiliation: R&D Department, Echosens, Paris, France; Institute of Cardiometabolism and Nutrition, ICAN, UMR INSERM/UPMC 1166, Nutrition Department, Pitié-Salpêtrière Hospital, Paris, France.
authors.forename: Mériem
authors.initials: M
authors.lastname: Abdennour
authors.affiliation: R&D Department, Echosens, Paris, France.
authors.forename: Michel
authors.initials: M
authors.lastname: Clet
authors.affiliation: R&D Department, Echosens, Paris, France.
authors.forename: Laurent
authors.initials: L
authors.lastname: Sandrin
authors.affiliation: Department of Anatomic Pathology, Assistance Publique-Hôpitaux de Paris, Pitié-Salpêtrière Hospital, Paris, France.
authors.forename: Gilles
authors.initials: G
authors.lastname: le Naour
authors.affiliation: Department of Anatomic Pathology, Assistance Publique-Hôpitaux de Paris, Beaujon Hospital, Clichy, France.
authors.forename: Pierre
authors.initials: P
authors.lastname: Bedossa
authors.affiliation: Institute of Cardiometabolism and Nutrition, ICAN, UMR INSERM/UPMC 1166, Nutrition Department, Pitié-Salpêtrière Hospital, Paris, France.
authors.forename: Joan
authors.initials: J
authors.lastname: Tordjman
authors.affiliation: Institute of Cardiometabolism and Nutrition, ICAN, UMR INSERM/UPMC 1166, Nutrition Department, Pitié-Salpêtrière Hospital, Paris, France.
authors.forename: Karine
authors.initials: K
authors.lastname: Clément
authors.affiliation: R&D Department, Echosens, Paris, France.
authors.forename: Véronique
authors.initials: V
authors.lastname: Miette
mesh_terms: D050153:Abdominal Fat / Q000000981:diagnostic imaging; D000328:Adult; D054459:Elasticity Imaging Techniques / Q000295:instrumentation* / Q000379:methods*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000000981:diagnostic imaging*; D019047:Phantoms, Imaging; D015203:Reproducibility of Results; D050151:Subcutaneous Fat / Q000000981:diagnostic imaging*
keywords: Abdominal subcutaneous adipose tissue; AdipoScan; Bariatric surgery; Obesity; Shear wave speed; Transient elastography