title: Treatment of breast cancer 2 (BRCA2)-mutant follicular dendritic cell sarcoma with a poly ADP-ribose polymerase (PARP) inhibitor: a case report.
abstract: BACKGROUND
  Follicular dendritic cell sarcoma is a rare tumour with clinical behaviour covering a spectrum from indolent to aggressive disease. Treatment recommendations are currently based on case reports and small series describing combinations of surgery, chemotherapy and radiotherapy providing the best patient outcomes. Recent knowledge on molecular aberrations in this disease have not yet impacted on therapeutic decisions.
  
  
  METHODS
  We describe a case of progressive follicular dendritic cell sarcoma of the lung and pleura, treated based on knowledge of the tumour's molecular aberrations. The patient was initially treated with surgery, chemotherapy and radiotherapy and developed disease progression. Mutation testing by Caris molecular intelligence demonstrated a breast cancer 2 gene mutation and further treatment with carboplatin and veliparib achieved disease stabilisation.
  
  
  CONCLUSIONS
  Understanding of the molecular profile of rare tumours is key to improve therapeutic decision making and patient outcomes.
authors.affiliation: Scientia Clinical Research, UNSW, Sydney, NSW, 2052, Australia. c.lemech@unsw.edu.au.|Faculty of Medicine, University of New South Wales, Sydney, NSW, 2052, Australia. c.lemech@unsw.edu.au.
authors.forename: Charlotte R
authors.initials: CR
authors.lastname: Lemech
authors.affiliation: Prince of Wales Hospital, Barker Street, Randwick, 2031, Australia.
authors.forename: Rachel
authors.initials: R
authors.lastname: Williams
authors.affiliation: Faculty of Medicine, University of New South Wales, Sydney, NSW, 2052, Australia.|Prince of Wales Hospital, Barker Street, Randwick, 2031, Australia.
authors.forename: Stephen R
authors.initials: SR
authors.lastname: Thompson
authors.affiliation: Royal Prince Alfred Medical Centre, 203/100 Carillon Avenue, Newtown, NSW, 2042, Australia.
authors.forename: Brian
authors.initials: B
authors.lastname: McCaughan
authors.affiliation: Faculty of Medicine, University of New South Wales, Sydney, NSW, 2052, Australia.|Prince of Wales Hospital, Barker Street, Randwick, 2031, Australia.
authors.forename: Melvin
authors.initials: M
authors.lastname: Chin
mesh_terms: D000368:Aged; D024682:BRCA2 Protein / Q000235:genetics*; D054740:Dendritic Cell Sarcoma, Follicular / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000235:genetics* / Q000473:pathology; D018450:Disease Progression; D005260:Female; D006801:Humans; D009154:Mutation / Q000235:genetics*; D000067856:Poly(ADP-ribose) Polymerase Inhibitors / Q000627:therapeutic use*; D011065:Poly(ADP-ribose) Polymerases / Q000378:metabolism*; D049268:Positron-Emission Tomography
chemical_list: D024682:BRCA2 Protein; D000067856:Poly(ADP-ribose) Polymerase Inhibitors; D011065:Poly(ADP-ribose) Polymerases
keywords: BRCA2 mutation; Case report; Follicular dendritic cell sarcoma; Veliparib