title: Metal-Organic-Framework-Derived Mesoporous Carbon Nanospheres Containing Porphyrin-Like Metal Centers for Conformal Phototherapy.
abstract: Mesoporous carbon nanospheres containing porphyrin-like metal centers (denoted as "PMCS") are successfully synthesized by the pyrolysis of an imidazolate framework using a mesoporous-silica protection strategy. The PMCS allow infrared and photoacoustic imaging and synergetic photothermal therapy/photodynamic therapy derived from the porphyrin-like moieties, offering the possibility of real-time monitoring of therapeutic processes and image-guided precise conformal phototherapy. PMCS thus represent a novel multifunctional theranostic platform for improved treatment efficiencies.
authors.affiliation: Beijing Key Laboratory of Bioprocess, Beijing Advanced Innovation Center for Soft Matter Science and Engineering, Beijing Laboratory of Biomedical Materials, Beijing University of Chemical Technology, Beijing, 100029, P. R. China.|Key Laboratory of Photochemical Conversion and Optoelectronic Materials, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing, 100190, P. R. China.|State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, 100085, P. R. China.|University of Chinese Academy of Sciences, Beijing, 100049, P. R. China.
authors.forename: Shunhao
authors.initials: S
authors.lastname: Wang
authors.affiliation: Key Laboratory of Photochemical Conversion and Optoelectronic Materials, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing, 100190, P. R. China.
authors.forename: Lu
authors.initials: L
authors.lastname: Shang
authors.affiliation: Beijing Institute of Nanoenergy and Nanosystems, National Center for Nanoscience and Technology (NCNST), Chinese Academy of Sciences, Beijing, 100083, P. R. China.
authors.forename: Linlin
authors.initials: L
authors.lastname: Li
authors.affiliation: Department of Materials Science and Engineering, State University of New York at Stony Brook, Stony Brook, NY, 11790, USA.
authors.forename: Yingjie
authors.initials: Y
authors.lastname: Yu
authors.affiliation: Key Laboratory of Molecular Imaging, The State Key Laboratory of Management and Control for Complex Systems, Institute of Automation, Chinese Academy of Sciences, Beijing, 100190, P. R. China.
authors.forename: Chongwei
authors.initials: C
authors.lastname: Chi
authors.affiliation: Key Laboratory of Molecular Imaging, The State Key Laboratory of Management and Control for Complex Systems, Institute of Automation, Chinese Academy of Sciences, Beijing, 100190, P. R. China.
authors.forename: Kun
authors.initials: K
authors.lastname: Wang
authors.affiliation: State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, 100085, P. R. China.|University of Chinese Academy of Sciences, Beijing, 100049, P. R. China.
authors.forename: Jie
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Key Laboratory of Photochemical Conversion and Optoelectronic Materials, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing, 100190, P. R. China.|University of Chinese Academy of Sciences, Beijing, 100049, P. R. China.
authors.forename: Run
authors.initials: R
authors.lastname: Shi
authors.affiliation: Beijing Key Laboratory of Bioprocess, Beijing Advanced Innovation Center for Soft Matter Science and Engineering, Beijing Laboratory of Biomedical Materials, Beijing University of Chemical Technology, Beijing, 100029, P. R. China.
authors.forename: Heyun
authors.initials: H
authors.lastname: Shen
authors.affiliation: School of Chemical Sciences, The University of Auckland, Auckland, 1142, New Zealand.
authors.forename: Geoffrey I N
authors.initials: GI
authors.lastname: Waterhouse
authors.affiliation: State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, 100085, P. R. China. sjliu@rcees.ac.cn.
authors.forename: Sijin
authors.initials: S
authors.lastname: Liu
authors.affiliation: Key Laboratory of Molecular Imaging, The State Key Laboratory of Management and Control for Complex Systems, Institute of Automation, Chinese Academy of Sciences, Beijing, 100190, P. R. China.
authors.forename: Jie
authors.initials: J
authors.lastname: Tian
authors.affiliation: Key Laboratory of Photochemical Conversion and Optoelectronic Materials, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing, 100190, P. R. China. tierui@mail.ipc.ac.cn.
authors.forename: Tierui
authors.initials: T
authors.lastname: Zhang
authors.affiliation: Beijing Key Laboratory of Bioprocess, Beijing Advanced Innovation Center for Soft Matter Science and Engineering, Beijing Laboratory of Biomedical Materials, Beijing University of Chemical Technology, Beijing, 100029, P. R. China. liuhy@mail.buct.edu.cn.
authors.forename: Huiyu
authors.initials: H
authors.lastname: Liu
mesh_terms: D002244:Carbon; D008670:Metals; D054118:Nanospheres; D010789:Phototherapy; D011166:Porphyrins
chemical_list: D008670:Metals; D011166:Porphyrins; D002244:Carbon
keywords: mesoporous carbon nanoframes; photodynamic therapy; photothermal therapy; porphyrin-like metal centers; reactive oxygen species