title: Protein-Based Multifunctional Nanocarriers for Imaging, Photothermal Therapy, and Anticancer Drug Delivery.
abstract: We report a simple approach for fabricating plasmonic and magneto-luminescent multifunctional nanocarriers (MFNCs) by assembling gold nanorods, iron oxide nanoparticles, and gold nanoclusters within BSA nanoparticles. The MFNCs showed self-tracking capability through single- and two-photon imaging, and the potential for magnetic targeting in vitro. Appreciable T2-relaxivity exhibited by the MFNCs indicated favorable conditions for magnetic resonance imaging. In addition to successful plasmonic-photothermal therapy of cancer cells (HeLa) in vitro, the MFNCs demonstrated efficient loading and delivery of doxorubicin to HeLa cells leading to significant cell death. The present MFNCs with their multimodal imaging and therapeutic capabilities could be eminent candidates for cancer theranostics.
authors.affiliation: Department of Chemistry and ‡ Centre for Nanotechnology, Indian Institute of Technology Guwahati , Guwahati 781039, Assam, India.
authors.forename: Uday Narayan
authors.initials: UN
authors.lastname: Pan
authors.affiliation: Department of Chemistry and ‡ Centre for Nanotechnology, Indian Institute of Technology Guwahati , Guwahati 781039, Assam, India.
authors.forename: Rumi
authors.initials: R
authors.lastname: Khandelia
authors.affiliation: Department of Chemistry and ‡ Centre for Nanotechnology, Indian Institute of Technology Guwahati , Guwahati 781039, Assam, India.
authors.forename: Pallab
authors.initials: P
authors.lastname: Sanpui
authors.affiliation: Department of Chemistry and ‡ Centre for Nanotechnology, Indian Institute of Technology Guwahati , Guwahati 781039, Assam, India.
authors.forename: Subhojit
authors.initials: S
authors.lastname: Das
authors.affiliation: Department of Chemistry and ‡ Centre for Nanotechnology, Indian Institute of Technology Guwahati , Guwahati 781039, Assam, India.
authors.forename: Anumita
authors.initials: A
authors.lastname: Paul
authors.affiliation: Department of Chemistry and ‡ Centre for Nanotechnology, Indian Institute of Technology Guwahati , Guwahati 781039, Assam, India.
authors.forename: Arun
authors.initials: A
authors.lastname: Chattopadhyay
mesh_terms: D000970:Antineoplastic Agents; D004317:Doxorubicin; D016503:Drug Delivery Systems; D006367:HeLa Cells; D006801:Humans; D008279:Magnetic Resonance Imaging; D049329:Nanostructures; D000068936:Theranostic Nanomedicine
chemical_list: D000970:Antineoplastic Agents; D004317:Doxorubicin
keywords: cancer theranostics; magnetic targeting; multifunctional nanocarriers; photoluminescence; photothermal therapy; two photon imaging