title: Rheology-sensitive response of zeolite-supported anti-inflammatory drug systems.
abstract: Drug release from inorganic supports is a challenge for the scientific community for various reasons, related to the low costs of the systems and the possibility of easily regulating the drug release. In the present work, surface-modified zeolite particles are used as carriers for non steroidal antiflammatory drugs (NSAIDs). The release of the drug has been studied in a solution that simulates the intestinal fluid as well as in a gel-like system, based on a surfactant and a binding salt. In the solution case, the quantity of drug released has been tracked via spectrophotometric assay. Release in the gel has been monitored by rheological methods. The molecular conformation of the NSAIDs is fundamental for the interaction with the zeolite surface, whose modified surface has a strong binding energy. It has been proven that the main mechanism for the drug release is anion exchange. It has been found that the NSAIDs, used in their sodic form, can act as binding salts by themselves in the gel-like system, thus changing the viscoelastic response of the overall solution. Drug release kinetics in the solution compare quantitatively well with the released drug in the gel-like fluid, as measured by rheometry.
authors.affiliation: Department of Chemical, Materials and Industrial Production Engineering, Università degli Studi di Napoli Federico II, P.le Tecchio 80, 80125 Napoli, Italy. Electronic address: r.pasquino@unina.it.
authors.forename: R
authors.initials: R
authors.lastname: Pasquino
authors.affiliation: Department of Chemical, Materials and Industrial Production Engineering, Università degli Studi di Napoli Federico II, P.le Tecchio 80, 80125 Napoli, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Di Domenico
authors.affiliation: Department of Science and Technology, University of Sannio, Via dei Mulini 59/A, 82100 Benevento, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Izzo
authors.affiliation: Department of Chemical, Materials and Industrial Production Engineering, Università degli Studi di Napoli Federico II, P.le Tecchio 80, 80125 Napoli, Italy.
authors.forename: D
authors.initials: D
authors.lastname: Gaudino
authors.affiliation: Department of Chemical, Materials and Industrial Production Engineering, Università degli Studi di Napoli Federico II, P.le Tecchio 80, 80125 Napoli, Italy.
authors.forename: V
authors.initials: V
authors.lastname: Vanzanella
authors.affiliation: Department of Chemical, Materials and Industrial Production Engineering, Università degli Studi di Napoli Federico II, P.le Tecchio 80, 80125 Napoli, Italy.
authors.forename: N
authors.initials: N
authors.lastname: Grizzuti
authors.affiliation: Department of Chemical, Materials and Industrial Production Engineering, Università degli Studi di Napoli Federico II, P.le Tecchio 80, 80125 Napoli, Italy.
authors.forename: B
authors.initials: B
authors.lastname: de Gennaro
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry*; D004337:Drug Carriers / Q000737:chemistry*; D065546:Drug Liberation; D012212:Rheology; D013501:Surface-Active Agents / Q000737:chemistry*; D014783:Viscosity; D017641:Zeolites / Q000737:chemistry*
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D004337:Drug Carriers; D013501:Surface-Active Agents; D017641:Zeolites
keywords: Binding salt; Drug release; Inorganic supports; Rheology; Surfactant