title: Smart Organic Two-Dimensional Materials Based on a Rational Combination of Non-covalent Interactions.
abstract: Rational design of organic 2D (O2D) materials has made some progress, but it is still in its infancy. A class of self-assembling small molecules is presented that form nano/microscale supramolecular 2D materials in aqueous media. A judicial combination of four different intermolecular interactions forms the basis for the robust formation of these ultrathin assemblies. These assemblies can be programmed to disassemble in response to a specific protein and release its non-covalently bound guest molecules.
authors.affiliation: Department of Chemistry, University of Massachusetts Amherst, Amherst, MA, 01003, USA.
authors.forename: Wei
authors.initials: W
authors.lastname: Bai
authors.affiliation: Department of Chemistry, University of Massachusetts Amherst, Amherst, MA, 01003, USA.
authors.forename: Ziwen
authors.initials: Z
authors.lastname: Jiang
authors.affiliation: Department of Polymer Science and Engineering, University of Massachusetts Amherst, Amherst, MA, 01003, USA.
authors.forename: Alexander E
authors.initials: AE
authors.lastname: Ribbe
authors.affiliation: Department of Chemistry, University of Massachusetts Amherst, Amherst, MA, 01003, USA. thai@chem.umass.edu.
authors.forename: S
authors.identifier: 0000-0002-6475-6726
authors.initials: S
authors.lastname: Thayumanavan
mesh_terms: D003692:Delayed-Action Preparations / Q000737:chemistry*; D016503:Drug Delivery Systems; D006860:Hydrogen Bonding; D057927:Hydrophobic and Hydrophilic Interactions; D049329:Nanostructures / Q000737:chemistry* / Q000648:ultrastructure; D009930:Organic Chemicals / Q000737:chemistry; D054852:Small Molecule Libraries / Q000737:chemistry; D055672:Static Electricity; D014867:Water / Q000737:chemistry
chemical_list: D003692:Delayed-Action Preparations; D009930:Organic Chemicals; D054852:Small Molecule Libraries; D014867:Water
keywords: controlled release; organic 2D materials; self-assembly; stimuli-responsive materials; ultra-thin assemblies