title: Peripheral sensory neuropathy is associated with altered postocclusive reactive hyperemia in the diabetic foot.
abstract: OBJECTIVE
  This study examined whether the presence of peripheral sensory neuropathy or cardiac autonomic deficits is associated with postocclusive reactive hyperemia (reflective of microvascular function) in the diabetic foot.
  
  
  METHODS
  99 participants with type 2 diabetes were recruited into this cross-sectional study. The presence of peripheral sensory neuropathy was determined with standard clinical tests and cardiac autonomic function was assessed with heart rate variation testing. Postocclusive reactive hyperemia was measured with laser Doppler in the hallux. Multiple hierarchical regression was performed to examine relationships between neuropathy and the peak perfusion following occlusion and the time to reach this peak.
  
  
  RESULTS
  Peripheral sensory neuropathy predicted 22% of the variance in time to peak following occlusion (p<0.05), being associated with a slower time to peak but was not associated with the magnitude of the peak. Heart rate variation was not associated with the postocclusive reactive hyperemia response.
  
  
  CONCLUSIONS
  This study found an association between the presence of peripheral sensory neuropathy in people with diabetes and altered microvascular reactivity in the lower limb.
authors.affiliation: Faculty of Health and Medicine , University of Newcastle , Ourimbah, New South Wales , Australia.
authors.forename: Alex L
authors.initials: AL
authors.lastname: Barwick
authors.affiliation: Faculty of Health and Medicine , University of Newcastle , Ourimbah, New South Wales , Australia.
authors.forename: John W
authors.initials: JW
authors.lastname: Tessier
authors.affiliation: Faculty of Science and Information Technology , University of Newcastle , Callaghan, New South Wales , Australia.
authors.forename: Xanne
authors.initials: X
authors.lastname: Janse de Jonge
authors.affiliation: Faculty of Health and Medicine , University of Newcastle , Ourimbah, New South Wales , Australia.
authors.forename: James R
authors.initials: JR
authors.lastname: Ivers
authors.affiliation: Faculty of Health and Medicine , University of Newcastle , Ourimbah, New South Wales , Australia.
authors.forename: Vivienne H
authors.initials: VH
authors.lastname: Chuter
keywords: Microvascular; Neuropathy; Neuropathy Complications; Neuropathy and Vascular Disease