title: Sensory Gating Deficits in First-Episode Psychosis: Evidence From Neurophysiology, Psychophysiology, and Neuropsychology.
abstract: Sensory gating deficits are commonly found in patients with schizophrenia. However, there is still scarce research on this issue. Thirty-eight patients with first-episode psychosis (FEP) were compared to thirty-eight controls. A condition-test paradigm of event-related potentials (ERP), prepulse inhibition (PPI), and some specific tasks of the MATRICS Consensus Cognitive Battery (MCCB) were used (i.e., TMT, BACS-SC, and Fluency for processing speed and CPT-IP for attention and vigilance). The ERP components measured were P50, N1, and P2. The PPI intervals examined were 30, 60, and 120 msec. Regarding the MCCB, processing speed and attention/vigilance cognitive domains were selected. FEP patients showed significant deficits in N1 and P2 components, at 30 and 60 PPI levels and in all the MCCB subtests selected. We obtained significant relationships in N1 with PPI-60, and with one MCCB subtest for processing speed. In addition, this same subtest showed significant association with P2. Therefore, sensory gating functioning is widely impaired since the very early stages of schizophrenia.
authors.affiliation: *Neuroscience Center, University of Helsinki, Helsinki, Finland; †Laboratory of Clinical Psychophysiology and ‡Department of Psychiatry, Hospital 12 de Octubre, Madrid; §Department of Basic Psychology II (Cognitive Processes), Complutense University of Madrid; ∥Centro de Investigación Biomédica en Red de Salud Mental, CIBERSAM, Madrid; ¶Department of Psychiatry, Complutense University of Madrid, Madrid, Spain; and #Department of Molecular and Cellular Neuroscience, The Scripps Research Institute, La Jolla, CA.
authors.forename: Isabel
authors.initials: I
authors.lastname: Morales-Muñoz
authors.forename: Rosa
authors.initials: R
authors.lastname: Jurado-Barba
authors.forename: Sara
authors.initials: S
authors.lastname: Fernández-Guinea
authors.forename: Roberto
authors.initials: R
authors.lastname: Rodríguez-Jiménez
authors.forename: Miguel Ángel
authors.initials: MÁ
authors.lastname: Jiménez-Arriero
authors.forename: José R
authors.initials: JR
authors.lastname: Criado
authors.forename: Gabriel
authors.initials: G
authors.lastname: Rubio
mesh_terms: D000161:Acoustic Stimulation / Q000379:methods; D000328:Adult; D004569:Electroencephalography / Q000379:methods; D005260:Female; D006801:Humans; D008297:Male; D009483:Neuropsychological Tests; D011602:Psychophysiologic Disorders / Q000175:diagnosis / Q000503:physiopathology / Q000523:psychology; D011603:Psychophysiology; D011618:Psychotic Disorders / Q000175:diagnosis / Q000503:physiopathology* / Q000523:psychology; D013216:Reflex, Startle / Q000502:physiology*; D012559:Schizophrenia / Q000175:diagnosis / Q000503:physiopathology*; D012565:Schizophrenic Psychology; D055139:Sensory Gating / Q000502:physiology*