title: Intralesional Injection of Bevacizumab for the Treatment of an Apical Orbital Cavernous Venous Malformation.
abstract: Surgical excision of orbital cavernous venous malformations located in the orbital apex is challenging due to difficulty obtaining surgical exposure and higher risk of morbidity. Intralesional bevacizumab injection has been utilized for the treatment of choroidal and intracranial cavernous venous malformations. A 52-year-old woman with an orbital apical mass consistent with a cavernous venous malformation causing decreased visual acuity, diminished color vision, and visual field loss was treated with intralesional bevacizumab injected under direct surgical visualization. Subsequently, she demonstrated improved visual acuity, color vision, and slow but dramatic visual field improvement over one year. Injection of bevacizumab may be a viable alternative treatment for orbital cavernous venous malformations.
authors.affiliation: Department of Ophthalmology (ARS, MC, AJA, CEF) and Department of Radiology (DAK), University of Washington, Seattle, Washington.
authors.forename: Adam R
authors.initials: AR
authors.lastname: Sweeney
authors.forename: Michael
authors.initials: M
authors.lastname: Chappell
authors.forename: Derek A
authors.initials: DA
authors.lastname: Khorsand
authors.forename: Arash
authors.initials: A
authors.lastname: Jian-Amadi
authors.forename: Courtney E
authors.initials: CE
authors.lastname: Francis
mesh_terms: D020533:Angiogenesis Inhibitors / Q000008:administration & dosage; D000068258:Bevacizumab / Q000008:administration & dosage*; D002426:Cavernous Sinus; D005260:Female; D006801:Humans; D015552:Injections, Intralesional; D002538:Intracranial Arteriovenous Malformations / Q000175:diagnosis / Q000188:drug therapy*; D008279:Magnetic Resonance Imaging
chemical_list: D020533:Angiogenesis Inhibitors; D000068258:Bevacizumab