title: Del Nido cardioplegia in the setting of minimally invasive aortic valve surgery.
abstract: The purpose of this study is to report our experience with del Nido cardioplegia (DNC) in the setting of minimally invasive aortic valve surgery. Forty-six consecutive patients underwent minimally invasive aortic valve replacement (AVR) through a "J" ministernotomy: twenty-five patients received the DNC (Group 1) and 21 patients received standard blood cardioplegia (SBC) (Group 2). The rate of ventricular fibrillation at unclamping was significantly lower in the DNC group (12% vs 52%, p=0.004), as well as postoperative creatinine kinase-MB (CK-MB) values (11.4±5.2 vs 17.7±6.9 µg/L, p=0.004). There were no deaths, myocardial infarctions or major complications in either group. Less postoperative use of intravenous insulin (28% vs 81%, p<0.001) was registered in the DNC group. In conclusion, the DNC is easy to use and safe during minimally invasive AVR, providing a myocardial protection at least equivalent to our SBC, improved surgical efficiency, minimal cost and less blood glucose perturbations.
authors.affiliation: 1 Department of Cardiac Surgery, Montreal Heart Institute and Université de Montréal, Montreal, Quebec, Canada.|2 Department of Clinical-Surgical, Diagnostic and Pediatric Sciences, Pavia University School of Medicine, Pavaia, Italy.
authors.forename: Nicola
authors.initials: N
authors.lastname: Vistarini
authors.affiliation: 1 Department of Cardiac Surgery, Montreal Heart Institute and Université de Montréal, Montreal, Quebec, Canada.
authors.forename: Eric
authors.initials: E
authors.lastname: Laliberté
authors.affiliation: 1 Department of Cardiac Surgery, Montreal Heart Institute and Université de Montréal, Montreal, Quebec, Canada.
authors.forename: Philippe
authors.initials: P
authors.lastname: Beauchamp
authors.affiliation: 1 Department of Cardiac Surgery, Montreal Heart Institute and Université de Montréal, Montreal, Quebec, Canada.
authors.forename: Ismail
authors.initials: I
authors.lastname: Bouhout
authors.affiliation: 1 Department of Cardiac Surgery, Montreal Heart Institute and Université de Montréal, Montreal, Quebec, Canada.
authors.forename: Yoan
authors.initials: Y
authors.lastname: Lamarche
authors.affiliation: 1 Department of Cardiac Surgery, Montreal Heart Institute and Université de Montréal, Montreal, Quebec, Canada.
authors.forename: Raymond
authors.initials: R
authors.lastname: Cartier
authors.affiliation: 1 Department of Cardiac Surgery, Montreal Heart Institute and Université de Montréal, Montreal, Quebec, Canada.
authors.forename: Michel
authors.initials: M
authors.lastname: Carrier
authors.affiliation: 1 Department of Cardiac Surgery, Montreal Heart Institute and Université de Montréal, Montreal, Quebec, Canada.
authors.forename: Louis
authors.initials: L
authors.lastname: Perrault
authors.affiliation: 1 Department of Cardiac Surgery, Montreal Heart Institute and Université de Montréal, Montreal, Quebec, Canada.
authors.forename: Denis
authors.initials: D
authors.lastname: Bouchard
authors.affiliation: 1 Department of Cardiac Surgery, Montreal Heart Institute and Université de Montréal, Montreal, Quebec, Canada.
authors.forename: Ismaïl
authors.initials: I
authors.lastname: El-Hamamsy
authors.affiliation: 1 Department of Cardiac Surgery, Montreal Heart Institute and Université de Montréal, Montreal, Quebec, Canada.
authors.forename: Michel
authors.initials: M
authors.lastname: Pellerin
authors.affiliation: 1 Department of Cardiac Surgery, Montreal Heart Institute and Université de Montréal, Montreal, Quebec, Canada.
authors.forename: Philippe
authors.initials: P
authors.lastname: Demers
mesh_terms: D000368:Aged; D001021:Aortic Valve / Q000601:surgery*; D001639:Bicarbonates / Q000627:therapeutic use; D002314:Cardioplegic Solutions / Q000627:therapeutic use*; D006324:Heart Arrest, Induced / Q000379:methods*; D019918:Heart Valve Prosthesis Implantation / Q000379:methods*; D006801:Humans; D008012:Lidocaine / Q000627:therapeutic use; D008274:Magnesium / Q000627:therapeutic use; D008353:Mannitol / Q000627:therapeutic use; D019060:Minimally Invasive Surgical Procedures / Q000379:methods*; D011188:Potassium / Q000627:therapeutic use; D016896:Treatment Outcome; D061567:Voltage-Gated Sodium Channel Blockers / Q000627:therapeutic use
chemical_list: D001639:Bicarbonates; D002314:Cardioplegic Solutions; D061567:Voltage-Gated Sodium Channel Blockers; D008353:Mannitol; D008012:Lidocaine; D008274:Magnesium; D011188:Potassium
keywords: aortic valve; del Nido cardioplegia; minimally invasive surgery