title: Harlequin Ichthyosis: A Surgical Perspective.
abstract: Limb constriction or encasement in patients with harlequin ichthyosis can cause tissue injury resulting in necrosis and auto-amputation. Surgical release of constrictive plaques has been previously demonstrated, but the perioperative and intraoperative considerations surrounding this infrequent intervention have not been discussed in detail. This report documents a case of harlequin ichthyosis requiring surgical treatment, focusing on the importance of early surgical consultation, risks of surgery, indications for and timing of surgical intervention, and the details of the operation.
authors.affiliation: Plastic and Reconstructive Surgery, Seattle Children's Hospital, Seattle, Washington. mitchpet@uw.edu.
authors.forename: Mitchell A
authors.initials: MA
authors.lastname: Pet
authors.affiliation: Dermatology, Seattle Children's Hospital, Seattle, Washington.
authors.forename: Deepti
authors.initials: D
authors.lastname: Gupta
authors.affiliation: Plastic and Reconstructive Surgery, Seattle Children's Hospital, Seattle, Washington.
authors.forename: Raymond W
authors.initials: RW
authors.lastname: Tse
mesh_terms: D017255:Acitretin / Q000627:therapeutic use; D000284:Administration, Oral; D003161:Compartment Syndromes / Q000517:prevention & control; D019299:Decompression, Surgical / Q000379:methods*; D062109:Dermatologic Surgical Procedures / Q000379:methods; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D017490:Ichthyosis, Lamellar / Q000175:diagnosis* / Q000188:drug therapy / Q000601:surgery*; D007231:Infant, Newborn; D035583:Rare Diseases; D018570:Risk Assessment; D012720:Severity of Illness Index; D013518:Surgery, Plastic / Q000379:methods; D016896:Treatment Outcome
chemical_list: D017255:Acitretin