title: rs61764370 polymorphism of Kras and risk of cancer in Caucasian population: A meta-analysis.
abstract: BACKGROUND
  Kras is an important oncogene that plays a pivotal role in carcinogenesis. Rs61764370 polymorphism in Kras 3'-untranslated region is a candidate factor for contributing susceptibility to cancer. However, the results of emerging studies concerning association between rs61764370 and cancer risk remain elusive.
  
  
  METHODS
  The association between rs61764370 and risk of cancer was evaluated in 30 studies including 14936. cases and 15168 controls.
  
  
  RESULTS
  Meta-analysis result showed that genotype. GT/GG of rs61764370 was not associated with cancer in Caucasian population. After stratifying the overall population into cancer type subgroups, no significant association was observed between genotype. GT/GG and ovarian, breast, colorectal, non.-small cell lung cancer or head-neck carcinoma in Caucasian population, respectively.
  
  
  CONCLUSIONS
  These results indicated that genotype. GT/GG of rs61764370 was not a genetic susceptible risk factor for cancer, and rs61764370 could not be used as a biomarker for estimating cancer risk in Caucasian population.
authors.affiliation: Department of Clinical Laboratory, Affiliated Fuding Hospital, Fujian University of Traditional Medicine, Fuding, Fujian, China.
authors.forename: Shi-Yan
authors.initials: SY
authors.lastname: Zhang
authors.affiliation: Department of Clinical Laboratory, Affiliated Fuding Hospital, Fujian University of Traditional Medicine, Fuding, Fujian, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Shi
mesh_terms: D000483:Alleles; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D009369:Neoplasms / Q000453:epidemiology* / Q000235:genetics*; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D017594:Publication Bias; D012306:Risk; D044465:White People / Q000235:genetics*; D018631:ras Proteins / Q000235:genetics*
chemical_list: D018631:ras Proteins