title: Actin Filament Structures in Migrating Cells.
abstract: Cell migration is necessary for several developmental processes in multicellular organisms. Furthermore, many physiological processes such as wound healing and immunological events in adult animals are dependent on cell migration. Consequently, defects in cell migration are linked to various diseases including immunological disorders as well as cancer progression and metastasis formation. Cell migration is driven by specific protrusive and contractile actin filament structures, but the types and relative contributions of these actin filament arrays vary depending on the cell type and the environment of the cell. In this chapter, we introduce the most important actin filament structures that contribute to mesenchymal and amoeboid cell migration modes and discuss the mechanisms by which the assembly and turnover of these structures are controlled by various actin-binding proteins.
authors.affiliation: Institute of Biotechnology, University of Helsinki, 56, 00014, Helsinki, Finland.
authors.forename: Jaakko
authors.initials: J
authors.lastname: Lehtimäki
authors.affiliation: Institute of Biotechnology, University of Helsinki, 56, 00014, Helsinki, Finland.
authors.forename: Markku
authors.initials: M
authors.lastname: Hakala
authors.affiliation: Institute of Biotechnology, University of Helsinki, 56, 00014, Helsinki, Finland. pekka.lappalainen@helsinki.fi.
authors.forename: Pekka
authors.initials: P
authors.lastname: Lappalainen
mesh_terms: D008841:Actin Cytoskeleton / Q000737:chemistry* / Q000502:physiology; D000818:Animals; D002465:Cell Movement; D006801:Humans; D009218:Myosins / Q000737:chemistry; D011554:Pseudopodia / Q000502:physiology; D022502:Stress Fibers / Q000737:chemistry / Q000502:physiology
chemical_list: D009218:Myosins
keywords: Actin-binding proteins; Blebbing; Cell migration; Filopodia; Invadopodia; Lamellipodia; Myosin II; Podosome; Stress fibers