title: New potential biomarkers of acetaminophen-induced hepatotoxicity.
abstract: Acetaminophen (APAP) is one of the most common antipyretic and analgesic drugs. Despite various precautions patients use APAP in amounts exceeding acceptable daily doses. APAP overdosing contributes to APAP intoxication, which leads to acute liver injury or necessity of exigent liver transplantation. Biomarkers that can be helpful in early diagnosis of liver injury during APAP overdosing are studied worldwide. This review presents recent reports on new potential biomarkers and their prospective application in clinical practice.
authors.affiliation: Department of Pharmaceutical Analysis, Medical University of Bialystok, Bialystok, Poland. Electronic address: ksiemionow2@student.umb.edu.pl.
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Siemionow
authors.affiliation: Department of Pharmaceutical Analysis, Medical University of Bialystok, Bialystok, Poland.
authors.forename: Joanna
authors.initials: J
authors.lastname: Teul
authors.affiliation: Department of Pharmaceutical Analysis, Medical University of Bialystok, Bialystok, Poland.
authors.forename: Paweł
authors.initials: P
authors.lastname: Drągowski
authors.affiliation: Department of Medicinal Chemistry, Medical University of Bialystok, Bialystok, Poland.
authors.forename: Jerzy
authors.initials: J
authors.lastname: Pałka
authors.affiliation: Department of Pharmaceutical Analysis, Medical University of Bialystok, Bialystok, Poland.
authors.forename: Wojciech
authors.initials: W
authors.lastname: Miltyk
mesh_terms: D000082:Acetaminophen / Q000009:adverse effects*; D000818:Animals; D015415:Biomarkers / Q000097:blood*; D001798:Blood Proteins / Q000378:metabolism; D004272:DNA, Mitochondrial / Q000235:genetics; D006801:Humans; D008107:Liver Diseases / Q000097:blood*; D035683:MicroRNAs / Q000097:blood
chemical_list: D015415:Biomarkers; D001798:Blood Proteins; D004272:DNA, Mitochondrial; D035683:MicroRNAs; D000082:Acetaminophen
keywords: Biomarkers; HMGB-1; Hepatotoxicity; K-18; Paracetamol