title: Multi-color magnetic particle imaging for cardiovascular interventions.
abstract: Magnetic particle imaging (MPI) uses magnetic fields to visualize the spatial distribution of superparamagnetic iron oxide nanoparticles (SPIOs). Guidance of cardiovascular interventions is seen as one possible application of MPI. To safely guide interventions, the vessel lumen as well as all required interventional devices have to be visualized and be discernible from each other. Until now, different tracer concentrations were used for discerning devices from blood in MPI, because only one type of SPIO could be imaged at a time. Recently, it was shown for 3D MPI that it is possible to separate different signal sources in one volume of interest, i.e. to visualize and discern different SPIOs or different binding states of the same SPIO. The approach was termed multi-color MPI. In this work, the use of multi-color MPI for differentiation of a SPIO coated guide wire (Terumo Radifocus 0.035″) from the lumen of a vessel phantom filled with diluted Resovist is demonstrated. This is achieved by recording dedicated system functions of the coating material containing solid Resovist and of liquid Resovist, which allows separation of their respective signal in the image reconstruction process. Assigning a color to the different signal sources results in a differentiation of guide wire and vessel phantom lumen into colored images.
authors.affiliation: Department of Radiology and Nuclear Medicine, University Hospital Schleswig Holstein, Lübeck, Germany.
authors.forename: Julian
authors.initials: J
authors.lastname: Haegele
authors.affiliation: Department of Radiology and Nuclear Medicine, University Hospital Schleswig Holstein, Lübeck, Germany.
authors.forename: Sarah
authors.initials: S
authors.lastname: Vaalma
authors.affiliation: Department of Radiology and Nuclear Medicine, University Hospital Schleswig Holstein, Lübeck, Germany.
authors.forename: Nikolaos
authors.initials: N
authors.lastname: Panagiotopoulos
authors.affiliation: Department of Radiology and Nuclear Medicine, University Hospital Schleswig Holstein, Lübeck, Germany.
authors.forename: Jörg
authors.initials: J
authors.lastname: Barkhausen
authors.affiliation: Department of Radiology and Nuclear Medicine, University Hospital Schleswig Holstein, Lübeck, Germany.
authors.forename: Florian M
authors.initials: FM
authors.lastname: Vogt
authors.affiliation: Philips Technologie GmbH Innovative Technologies, Research Laboratories, Hamburg, Germany.
authors.forename: Jörn
authors.initials: J
authors.lastname: Borgert
authors.affiliation: Philips Technologie GmbH Innovative Technologies, Research Laboratories, Hamburg, Germany.
authors.forename: Jürgen
authors.initials: J
authors.lastname: Rahmer
mesh_terms: D003116:Color; D003952:Diagnostic Imaging / Q000295:instrumentation* / Q000379:methods*; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D021621:Imaging, Three-Dimensional / Q000295:instrumentation / Q000379:methods; D058185:Magnetite Nanoparticles / Q000008:administration & dosage / Q000737:chemistry*; D008955:Models, Cardiovascular; D019047:Phantoms, Imaging
chemical_list: D058185:Magnetite Nanoparticles