title: Anti-inflammatory and antinociceptive activities of Solenostemon monostachyus aerial part extract in mice.
abstract: OBJECTIVE
  Solenostemon monostachyus is used in traditional medicine for the treatment of various ailments such as ulcer, hypertension, pains and inflammatory diseases. Evaluation of anti-inflammatory and analgesic activities of S. monostachyus aerial parts was carried out to ascertain its uses in traditional medicine.
  
  
  METHODS
  The aerial parts of S. monostachyus was cold extracted by soaking the dried powdered material in ethanol. The aerial parts crude extract (75 -225 mg/kg) of S. monostachyus was investigated for analgesic and anti-inflammatory activities using various experimental models; acetic acid, formalin and thermal- induced pains models for analgesic study and carrageenin, egg albumin and xylene - induced edema models for anti-inflammatory investigation.
  
  
  RESULTS
  The extract caused a significant (p<0.05 - 0.001) dose-dependent reduction of inflammation and pains induced by different phlogistic agents used. These effects were comparable to those of the standard drug, (ASA, 100 mg/kg) used in some models.
  
  
  CONCLUSIONS
  The anti-inflammatory and analgesic effects of this plant may in part be mediated through the chemical constituents of the plant and the results of the analgesic action suggest central and peripheral mechanisms. The findings of this work confirm the ethno medical use of this plant to treat inflammatory conditions.
authors.affiliation: Department of Pharmacology and Toxicology, Faculty of Pharmacy, University of Uyo, Uyo, Nigeria.
authors.forename: Jude Fiom
authors.initials: JF
authors.lastname: Okokon
authors.affiliation: Department of Physiology, Faculty of Basic Medical Sciences, University of Uyo, Uyo, Nigeria.
authors.forename: Koofreh
authors.initials: K
authors.lastname: Davis
authors.affiliation: Department of Pharmacology and Toxicology, Faculty of Pharmacy, Niger Delta University, Wilberforce Island, Bayelsa State.
authors.forename: Lucky Legbosi
authors.initials: LL
authors.lastname: Nwidu
keywords: Analgesic; Anti-inflammatory; Solenostemon monostachyus