title: The role of sub-hippocampal versus hippocampal regions in bitemporal lobe epilepsies.
abstract: OBJECTIVE
  We aimed at better delineating the functional anatomical organization of bitemporal lobe epilepsy.
  
  
  METHODS
  We studied the epileptogenic zone (EZ) by quantifying the epileptogenicity of brain structures explored by depth electrodes in patients investigated by stereoelectroencephalography (SEEG). We compared 15 patients with bilateral mesial temporal lobe epilepsy (BTLE) and 15 patients with unilateral mesial temporal lobe epilepsy (UTLE). This quantification was performed using the 'Epileptogenicity Index' (EI).
  
  
  RESULTS
  Age at epilepsy onset, and epilepsy duration, were not statistically different in both groups. UTLE patients more frequently displayed maximal epileptogenicity in hippocampal structures, whereas BTLE patients had maximal values in subhippocampal areas (entorhinal cortex, temporal pole, parahippocampal cortex).
  
  
  CONCLUSIONS
  Our results suggest different organization of the EZ in the two groups.
  
  
  CONCLUSIONS
  BTLE was associated with more involvement of subhippocampal regions, a result in agreement with known anatomical connections between the two temporal lobes.
authors.affiliation: CHU Timone, Service de Neurophysiologie Clinique, Marseille, France; Aix Marseille Univ, Inserm, INS, Institut de Neurosciences des Systèmes, Marseille, France.
authors.forename: Sandrine
authors.initials: S
authors.lastname: Aubert
authors.affiliation: CHU Timone, Service de Neurophysiologie Clinique, Marseille, France; Federation Hospitalo Universitaire (FHU) «Epinext» A*MIDEX, Aix Marseille Université, France.
authors.forename: Francesca
authors.initials: F
authors.lastname: Bonini
authors.affiliation: Service des Neurologie et d'Explorations Neurophysiologiques Fonctionnelles Neurologiques, Hôpital Pierre Paul Riquet, Rangueil, et CERCO, UMR 5549, CNRS, Université de Toulouse, Toulouse, France.
authors.forename: Jonathan
authors.initials: J
authors.lastname: Curot
authors.affiliation: Service des Neurologie et d'Explorations Neurophysiologiques Fonctionnelles Neurologiques, Hôpital Pierre Paul Riquet, Rangueil, et CERCO, UMR 5549, CNRS, Université de Toulouse, Toulouse, France.
authors.forename: Luc
authors.initials: L
authors.lastname: Valton
authors.affiliation: Service de Neurophysiologie Clinique, Hôpital Salengro, Lille, France.
authors.forename: William
authors.initials: W
authors.lastname: Szurhaj
authors.affiliation: Service de Neurophysiologie Clinique, Hôpital Salengro, Lille, France.
authors.forename: Philippe
authors.initials: P
authors.lastname: Derambure
authors.affiliation: Service de Neurologie Fonctionnelle et Epileptologie, Hospices Civils de Lyon, France.
authors.forename: Sylvain
authors.initials: S
authors.lastname: Rheims
authors.affiliation: Service de Neurologie Fonctionnelle et Epileptologie, Hospices Civils de Lyon, France.
authors.forename: Philippe
authors.initials: P
authors.lastname: Ryvlin
authors.affiliation: Université de Rennes 1, LTSI, INSERM, U642, Rennes, France.
authors.forename: Fabrice
authors.initials: F
authors.lastname: Wendling
authors.affiliation: CHU Timone, Service de Neurophysiologie Clinique, Marseille, France; Federation Hospitalo Universitaire (FHU) «Epinext» A*MIDEX, Aix Marseille Université, France.
authors.forename: Aileen
authors.initials: A
authors.lastname: McGonigal
authors.affiliation: CHU Timone, Service de Neurophysiologie Clinique, Marseille, France; Federation Hospitalo Universitaire (FHU) «Epinext» A*MIDEX, Aix Marseille Université, France.
authors.forename: Agnes
authors.initials: A
authors.lastname: Trébuchon
authors.affiliation: CHU Timone, Service de Neurophysiologie Clinique, Marseille, France; Aix Marseille Univ, Inserm, INS, Institut de Neurosciences des Systèmes, Marseille, France; Federation Hospitalo Universitaire (FHU) «Epinext» A*MIDEX, Aix Marseille Université, France. Electronic address: fabrice.bartolomei@ap-hm.fr.
authors.forename: Fabrice
authors.initials: F
authors.lastname: Bartolomei
mesh_terms: D000293:Adolescent; D001931:Brain Mapping / Q000379:methods; D002648:Child; D004569:Electroencephalography / Q000379:methods*; D004833:Epilepsy, Temporal Lobe / Q000175:diagnosis* / Q000503:physiopathology*; D005260:Female; D006624:Hippocampus / Q000503:physiopathology*; D006801:Humans; D008297:Male; D013238:Stereotaxic Techniques; D055815:Young Adult
keywords: Bilateral temporal epilepsy; Entorhinal cortex; Epileptogenicity Index; SEEG; Surgery