title: An in-tether sulfilimine chiral center induces helicity in short peptides.
abstract: A precisely positioned sulfilimine chiral center in the tether of a stabilized peptide would determine the peptide's secondary structure. Peptide sulfilimines could be prepared by a facile chloramine T oxidation and the two resulting peptide diastereomers showed significant differences in their secondary structures, which were supported by circular dichroism spectroscopy and NMR.
authors.affiliation: School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, Shenzhen, 518055, China. lizg@pkusz.edu.cn.
authors.forename: Huacan
authors.initials: H
authors.lastname: Lin
authors.affiliation: School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, Shenzhen, 518055, China. lizg@pkusz.edu.cn.
authors.forename: Yixiang
authors.initials: Y
authors.lastname: Jiang
authors.affiliation: School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, Shenzhen, 518055, China. lizg@pkusz.edu.cn.
authors.forename: Qingzhou
authors.initials: Q
authors.lastname: Zhang
authors.affiliation: School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, Shenzhen, 518055, China. lizg@pkusz.edu.cn.
authors.forename: Kuan
authors.initials: K
authors.lastname: Hu
authors.affiliation: School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, Shenzhen, 518055, China. lizg@pkusz.edu.cn.
authors.forename: Zigang
authors.initials: Z
authors.lastname: Li
mesh_terms: D002942:Circular Dichroism; D007097:Imines / Q000138:chemical synthesis / Q000737:chemistry*; D010456:Peptides, Cyclic / Q000138:chemical synthesis / Q000737:chemistry*; D000072756:Protein Conformation, alpha-Helical; D011489:Protein Denaturation; D055550:Protein Stability; D066244:Proton Magnetic Resonance Spectroscopy; D013237:Stereoisomerism; D013696:Temperature
chemical_list: D007097:Imines; D010456:Peptides, Cyclic