title: The Use of Redox Expression and Associated Molecular Damage to Evaluate the Inflammatory Response in Critically Ill Patient with Severe Burn.
abstract: The patient with severe burns always represents a challenge for the trauma team due to the severe biochemical and physiopathological disorders. Although there are many resuscitation protocols of severe burn patient, systemic inflammatory response, oxidative stress, decreased immune response, infections, and multiple organ dysfunction syndromes are still secondary complications of trauma, present at maximum intensity in this type of patients. Currently there are numerous studies regarding the evaluation, monitoring, and minimizing the side effects induced by free radicals through antioxidant therapy. In this study, we want to introduce biochemical and physiological aspects of oxidative stress in patients with severe burns and to summarize the biomarkers used presently in the intensive care units. Systemic inflammations and infections are according to the literature the most important causes of death in these type of patients, being directly involved in multiple organ dysfunction syndrome and death.
authors.affiliation: Faculty of Pharmacy, "Victor Babes" University of Medicine and Pharmacy, Timisoara, Romania.
authors.forename: Lavinia Melania
authors.initials: LM
authors.lastname: Bratu
authors.affiliation: Faculty of Medicine, "Victor Babes" University of Medicine and Pharmacy, Timisoara, Romania. alexandru.rogobete@umft.ro.|Clinic of Aneshtesia and Intensive Care, Emergency County Hospital "Pius Brinzeu", Bd. Iosif Bulbuca nr.10, 300736, Timisoara, Romania. alexandru.rogobete@umft.ro.
authors.forename: Alexandru Florin
authors.identifier: http://orcid.org/0000-0003-1286-4431
authors.initials: AF
authors.lastname: Rogobete
authors.affiliation: Faculty of Medicine, "Victor Babes" University of Medicine and Pharmacy, Timisoara, Romania.|Clinic of Aneshtesia and Intensive Care, Emergency County Hospital "Pius Brinzeu", Bd. Iosif Bulbuca nr.10, 300736, Timisoara, Romania.
authors.forename: Dorel
authors.initials: D
authors.lastname: Sandesc
authors.affiliation: Faculty of Medicine, "Victor Babes" University of Medicine and Pharmacy, Timisoara, Romania.|Clinic of Aneshtesia and Intensive Care, Emergency County Hospital "Pius Brinzeu", Bd. Iosif Bulbuca nr.10, 300736, Timisoara, Romania.
authors.forename: Ovidiu Horea
authors.initials: OH
authors.lastname: Bedreag
authors.affiliation: Faculty of Medicine, "Victor Babes" University of Medicine and Pharmacy, Timisoara, Romania.
authors.forename: Sonia
authors.initials: S
authors.lastname: Tanasescu
authors.affiliation: Faculty of Medicine, "Victor Babes" University of Medicine and Pharmacy, Timisoara, Romania.
authors.forename: Razvan
authors.initials: R
authors.lastname: Nitu
authors.affiliation: Faculty of Medicine, "Victor Babes" University of Medicine and Pharmacy, Timisoara, Romania.
authors.forename: Sonia Elena
authors.initials: SE
authors.lastname: Popovici
authors.affiliation: Faculty of Medicine, "Victor Babes" University of Medicine and Pharmacy, Timisoara, Romania.
authors.forename: Zorin Petrisor
authors.initials: ZP
authors.lastname: Crainiceanu
mesh_terms: D002056:Burns / Q000235:genetics*; D016638:Critical Illness; D005786:Gene Expression Regulation; D005819:Genetic Markers / Q000235:genetics; D006801:Humans; D007249:Inflammation / Q000235:genetics*; D018384:Oxidative Stress
chemical_list: D005819:Genetic Markers
keywords: Antioxidants; Molecular damage; Oxidative stress; Severe burns; microRNAs