title: Diphenyl diselenide attenuates oxidative stress and inflammatory parameters in ulcerative colitis: A comparison with ebselen.
abstract: OBJECTIVE
  The aim of this study was to evaluate the effects of diphenyl diselenide (PhSe)2 and ebselen (EB) in ulcerative colitis (UC) induced by dextran sulfate sodium (DSS) in rats.
  
  
  METHODS
  The effects of (PhSe)2 and EB in rats submitted to DSS-induced colitis were determined by measurement of oxidative stress parameters, inflammatory response and bowel histopathological alterations.
  
  
  RESULTS
  Animals developed moderate to severe neutrophil infiltration in histopathology assay in DSS rats and (PhSe)2 improved this response. Moreover, the treatment with (PhSe)2 decreased the oxidative damage in lipids and proteins, as well as reversed the superoxide dismutase (SOD) and catalase (CAT) levels in rats treated with DSS. EB was able only to reverse damage in lipids and the low levels of SOD in this animal model.
  
  
  CONCLUSIONS
  The organoselenium compounds tested demonstrated an anti-inflammatory and antioxidant activity reducing the colon damage, being (PhSe)2 more effective than EB.
authors.affiliation: Clinical and Experimental Pathophysiology Laboratory, Graduate Program in Health Sciences, University of South Santa Catarina, Tubarão, SC, Brazil. Electronic address: fabricia.petronilho@unisul.br.
authors.forename: Fabricia
authors.initials: F
authors.lastname: Petronilho
authors.affiliation: Clinical and Experimental Pathophysiology Laboratory, Graduate Program in Health Sciences, University of South Santa Catarina, Tubarão, SC, Brazil.
authors.forename: Monique
authors.initials: M
authors.lastname: Michels
authors.affiliation: Clinical and Experimental Pathophysiology Laboratory, Graduate Program in Health Sciences, University of South Santa Catarina, Tubarão, SC, Brazil.
authors.forename: Lucinéia G
authors.initials: LG
authors.lastname: Danielski
authors.affiliation: Clinical and Experimental Pathophysiology Laboratory, Graduate Program in Health Sciences, University of South Santa Catarina, Tubarão, SC, Brazil.
authors.forename: Mariana Pereira
authors.initials: MP
authors.lastname: Goldim
authors.affiliation: Clinical and Experimental Pathophysiology Laboratory, Graduate Program in Health Sciences, University of South Santa Catarina, Tubarão, SC, Brazil.
authors.forename: Drielly
authors.initials: D
authors.lastname: Florentino
authors.affiliation: Clinical and Experimental Pathophysiology Laboratory, Graduate Program in Health Sciences, University of South Santa Catarina, Tubarão, SC, Brazil.
authors.forename: Andriele
authors.initials: A
authors.lastname: Vieira
authors.affiliation: Clinical and Experimental Pathophysiology Laboratory, Graduate Program in Health Sciences, University of South Santa Catarina, Tubarão, SC, Brazil.
authors.forename: Mariana G
authors.initials: MG
authors.lastname: Mendonça
authors.affiliation: Clinical and Experimental Pathophysiology Laboratory, Graduate Program in Health Sciences, University of South Santa Catarina, Tubarão, SC, Brazil.
authors.forename: Moema
authors.initials: M
authors.lastname: Tournier
authors.affiliation: Clinical and Experimental Pathophysiology Laboratory, Graduate Program in Health Sciences, University of South Santa Catarina, Tubarão, SC, Brazil.
authors.forename: Bárbara
authors.initials: B
authors.lastname: Piacentini
authors.affiliation: Clinical and Experimental Pathophysiology Laboratory, Graduate Program in Health Sciences, University of South Santa Catarina, Tubarão, SC, Brazil.
authors.forename: Amanda Della
authors.initials: AD
authors.lastname: Giustina
authors.affiliation: Laboratory of Molecular and Cellular Biology, Graduate Program in Health Sciences, Health Sciences Unit, University of Southern Santa Catarina, Criciúma, SC, Brazil.
authors.forename: Daniela D
authors.initials: DD
authors.lastname: Leffa
authors.affiliation: Department of Pathology, Federal University of São Paulo, Sao Paulo, SP, Brazil.
authors.forename: Gregório W
authors.initials: GW
authors.lastname: Pereira
authors.affiliation: Institute of Pathological Anatomy and Histopathology DI-PREVER, Tubarão, SC, Brazil.
authors.forename: Volnei D
authors.initials: VD
authors.lastname: Pereira
authors.affiliation: Department of Biochemistry and Molecular Biology, Natural and Exact Sciences Centers, Federal University of Santa Maria, Santa Maria, RS, Brazil.
authors.forename: João Batista Teixeira Da
authors.initials: JB
authors.lastname: Rocha
mesh_terms: D000818:Animals; D001393:Azoles / Q000494:pharmacology / Q000627:therapeutic use*; D001555:Benzene Derivatives / Q000494:pharmacology / Q000627:therapeutic use*; D002374:Catalase / Q000378:metabolism; D003092:Colitis / Q000139:chemically induced / Q000188:drug therapy* / Q000378:metabolism; D003106:Colon / Q000187:drug effects / Q000378:metabolism; D004195:Disease Models, Animal; D007249:Inflammation / Q000139:chemically induced / Q000188:drug therapy* / Q000378:metabolism; D054833:Isoindoles; D008297:Male; D009504:Neutrophils; D016566:Organoselenium Compounds / Q000494:pharmacology / Q000627:therapeutic use*; D018384:Oxidative Stress / Q000187:drug effects*; D051381:Rats; D017208:Rats, Wistar; D017382:Reactive Oxygen Species / Q000378:metabolism; D013482:Superoxide Dismutase / Q000378:metabolism
chemical_list: D001393:Azoles; D001555:Benzene Derivatives; D054833:Isoindoles; D016566:Organoselenium Compounds; D017382:Reactive Oxygen Species; C061132:diphenyldiselenide; C042986:ebselen; D002374:Catalase; D013482:Superoxide Dismutase
keywords: DSS induced-colitis; Diphenyl diselenide; Ebselen; Oxidative stress; Ulcerative colitis