title: Indole molecules as inhibitors of tubulin polymerization: potential new anticancer agents, an update (2013-2015).
abstract: Discovery of new indole-based tubulin polymerization inhibitors will continue to dominate the synthetic efforts of many medicinal chemists working in the field. The indole ring system is an essential part of several tubulin inhibitors identified in the recent years. The present review article will update the synthesis, anticancer and tubulin inhibition activities of several important new indole classes such as 2-phenylindoles (28, 29 & 30), oxindoles (35 & 38), indole-3-acrylamides (44), indolines (46), aroylindoles (49), carbozoles (75, 76 & 82), azacarbolines (87) and annulated indoles (100-105).
authors.affiliation: Pharmaceutical Sciences Department, College of Pharmacy, Rosalind Franklin University of Medicine & Science, 3333 Green Bay Road, North Chicago, IL 60064, USA.
authors.forename: Renukadevi
authors.initials: R
authors.lastname: Patil
authors.affiliation: Centre for Nano & Material Sciences, Jain University, Jain Global Campus, Bangalore 562112, Karnataka, India.
authors.forename: Siddappa A
authors.initials: SA
authors.lastname: Patil
authors.affiliation: Department of Microbiology & Immunology, Chicago Medical School, Rosalind Franklin University of Medicine & Science, 3333 Green Bay Road, North Chicago, IL 60064, USA.
authors.forename: Kenneth D
authors.initials: KD
authors.lastname: Beaman
authors.affiliation: Pharmaceutical Sciences Department, College of Pharmacy, Rosalind Franklin University of Medicine & Science, 3333 Green Bay Road, North Chicago, IL 60064, USA.
authors.forename: Shivaputra A
authors.initials: SA
authors.lastname: Patil
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D055808:Drug Discovery; D006801:Humans; D007211:Indoles / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D008968:Molecular Conformation; D009369:Neoplasms / Q000188:drug therapy* / Q000378:metabolism; D058105:Polymerization / Q000187:drug effects; D014404:Tubulin / Q000378:metabolism*; D050257:Tubulin Modulators / Q000494:pharmacology*
chemical_list: D000970:Antineoplastic Agents; D007211:Indoles; D014404:Tubulin; D050257:Tubulin Modulators; C030374:indole
keywords: anticancer; carboline; colchicine; design; drug; indole; structure–activity relationship; synthesis; tubulin inhibitors