title: Combined with Bone Marrow-Derived Cells and rhBMP-2 for Osteonecrosis after Femoral Neck Fractures in Children and Adolescents: A case series.
abstract: Osteonecrosis of the femoral head (ONFH) following femoral neck fractures is a rare, yet severe, disorder in children and adolescents. This study evaluated the effectiveness of core decompression (CD) combined with implantation of bone marrow-derived cells (BMDC) and rhBMP-2 for osteonecrosis of femoral head (ONFH) after femoral neck fractures in children and adolescents. This study included 51 patients, aged 11.4-18.1 years, with ARCO stages I-III ONFH after femoral neck fractures between 2004 and 2010. The hips were divided into two groups based on whether the lateral pillar of the femoral head (LPFH) was preserved: LPFH and non-LPFH groups. All patients were followed up clinically and radiographically for a minimum of 5 years. 44 patients (86.3%) had improved clinical outcome. Radiologically, 9 of the 51 hips (17.6%) exhibited collapse onset or progression of the femoral head or narrowing of the hip joint space, and one patient in the non-LPFH group required hip arthroplasty due to the worsened syndrome. The technique provided an effective therapeutic option for children and adolescents with ONFH following femoral neck fractures. It relieves hip pain and prevents the progression of osteonecrosis in young patients lasting more than 5 years after surgery.
authors.affiliation: Centre for Osteonecrosis and Joint-Preserving &Reconstruction, Department of Orthopedics, Beijing Key Laboratory of Arthritic and Rheumatic Diseases, China-Japan Friendship Hospital, National Health and Family Planning Commission of the People's Republic of China, Beijing 100029, China.
authors.forename: Fuqiang
authors.initials: F
authors.lastname: Gao
authors.affiliation: Centre for Osteonecrosis and Joint-Preserving &Reconstruction, Department of Orthopedics, Beijing Key Laboratory of Arthritic and Rheumatic Diseases, China-Japan Friendship Hospital, National Health and Family Planning Commission of the People's Republic of China, Beijing 100029, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Sun
authors.affiliation: Centre for Osteonecrosis and Joint-Preserving &Reconstruction, Department of Orthopedics, Beijing Key Laboratory of Arthritic and Rheumatic Diseases, China-Japan Friendship Hospital, National Health and Family Planning Commission of the People's Republic of China, Beijing 100029, China.
authors.forename: Wanshou
authors.initials: W
authors.lastname: Guo
authors.affiliation: Centre for Osteonecrosis and Joint-Preserving &Reconstruction, Department of Orthopedics, Beijing Key Laboratory of Arthritic and Rheumatic Diseases, China-Japan Friendship Hospital, National Health and Family Planning Commission of the People's Republic of China, Beijing 100029, China.
authors.forename: Bailiang
authors.initials: B
authors.lastname: Wang
authors.affiliation: Centre for Osteonecrosis and Joint-Preserving &Reconstruction, Department of Orthopedics, Beijing Key Laboratory of Arthritic and Rheumatic Diseases, China-Japan Friendship Hospital, National Health and Family Planning Commission of the People's Republic of China, Beijing 100029, China.
authors.forename: Liming
authors.initials: L
authors.lastname: Cheng
authors.affiliation: Centre for Osteonecrosis and Joint-Preserving &Reconstruction, Department of Orthopedics, Beijing Key Laboratory of Arthritic and Rheumatic Diseases, China-Japan Friendship Hospital, National Health and Family Planning Commission of the People's Republic of China, Beijing 100029, China.
authors.forename: Zirong
authors.initials: Z
authors.lastname: Li
mesh_terms: D000293:Adolescent; D001854:Bone Marrow Cells; D016026:Bone Marrow Transplantation; D055396:Bone Morphogenetic Protein 2 / Q000008:administration & dosage*; D002648:Child; D005260:Female; D005265:Femoral Neck Fractures / Q000150:complications / Q000000981:diagnostic imaging / Q000628:therapy*; D006801:Humans; D008297:Male; D010020:Osteonecrosis / Q000000981:diagnostic imaging / Q000209:etiology / Q000628:therapy*; D011994:Recombinant Proteins / Q000008:administration & dosage
chemical_list: C525718:BMP2 protein, human; D055396:Bone Morphogenetic Protein 2; D011994:Recombinant Proteins