title: Bloodstream Infections Caused by Klebsiella pneumoniae Carbapenemase 2-producing K. pneumoniae at a Hematology Department in Wenzhou, China.
abstract: The increasing prevalence of Klebsiella pneumoniae carbapenemase 2-producing K. pneumoniae (KPC-2-KP) infections can become a new life-threatening complication for hematological patients. Five cases of KPC-2-KP bloodstream infections have been identified in our hematology department over the past 10 years. The current treatment options do not show satisfactory efficacy, especially for bloodstream infections. The treatment of these five cases was unsuccessful, mainly due to the high minimum inhibitory concentrations of carbapenem, fosfomycin resistance, or the inaccessibility of polymyxin. Further investigations into the optimal treatment modalities are therefore imperative. The present study provides insights into the epidemiology and clinical challenges of treating KPC-2-KP bloodstream infections.
authors.affiliation: Department of Hematology, The First Affiliated Hospital of Wenzhou Medical University, China.
authors.forename: Chongyun
authors.initials: C
authors.lastname: Xing
authors.forename: Bei
authors.initials: B
authors.lastname: Ge
authors.forename: Kang
authors.initials: K
authors.lastname: Yu
authors.forename: Shenmeng
authors.initials: S
authors.lastname: Gao
authors.forename: Bin
authors.initials: B
authors.lastname: Liang
authors.forename: Haige
authors.initials: H
authors.lastname: Ye
mesh_terms: D000328:Adult; D000368:Aged; D016470:Bacteremia / Q000382:microbiology*; D001426:Bacterial Proteins / Q000302:isolation & purification* / Q000378:metabolism; D002681:China; D015964:Gene Expression Regulation, Bacterial; D006801:Humans; D007710:Klebsiella Infections / Q000382:microbiology*; D007711:Klebsiella pneumoniae / Q000302:isolation & purification*; D008297:Male; D008875:Middle Aged; D001618:beta-Lactamases / Q000302:isolation & purification*
chemical_list: D001426:Bacterial Proteins; D001618:beta-Lactamases; C063912:carbapenemase