title: Template-Directed Synthesis of Porous and Protective Core-Shell Bionanoparticles.
abstract: Metal-organic frameworks (MOFs) are promising high surface area coordination polymers with tunable pore structures and functionality; however, a lack of good size and morphological control over the as-prepared MOFs has persisted as an issue in their application. Herein, we show how a robust protein template, tobacco mosaic virus (TMV), can be used to regulate the size and shape of as-fabricated MOF materials. We were able to obtain discrete rod-shaped TMV@MOF core-shell hybrids with good uniformity, and their diameters could be tuned by adjusting the synthetic conditions, which can also significantly impact the stability of the core-shell composite. More interestingly, the virus particle underneath the MOF shell can be chemically modified using a standard bioconjugation reaction, showing mass transportation within the MOF shell.
authors.affiliation: Department of Chemistry and Biochemistry, The University of Texas at Dallas, 800 W Campbell Rd, Richardson, TX, 75080, USA.
authors.forename: Shaobo
authors.initials: S
authors.lastname: Li
authors.affiliation: Department of Chemistry and Biochemistry, The University of Texas at Dallas, 800 W Campbell Rd, Richardson, TX, 75080, USA.
authors.forename: Madushani
authors.initials: M
authors.lastname: Dharmarwardana
authors.affiliation: Department of Chemistry and Biochemistry, The University of Texas at Dallas, 800 W Campbell Rd, Richardson, TX, 75080, USA.
authors.forename: Raymond P
authors.initials: RP
authors.lastname: Welch
authors.affiliation: Department of Chemistry and Biochemistry, The University of Texas at Dallas, 800 W Campbell Rd, Richardson, TX, 75080, USA.
authors.forename: Yixin
authors.initials: Y
authors.lastname: Ren
authors.affiliation: Department of Chemistry and Biochemistry, The University of Texas at Dallas, 800 W Campbell Rd, Richardson, TX, 75080, USA.
authors.forename: Christina M
authors.initials: CM
authors.lastname: Thompson
authors.affiliation: Department of Chemistry and Biochemistry, The University of Texas at Dallas, 800 W Campbell Rd, Richardson, TX, 75080, USA.
authors.forename: Ronald A
authors.initials: RA
authors.lastname: Smaldone
authors.affiliation: Department of Chemistry and Biochemistry, The University of Texas at Dallas, 800 W Campbell Rd, Richardson, TX, 75080, USA. gassensmith@utdallas.edu.
authors.forename: Jeremiah J
authors.initials: JJ
authors.lastname: Gassensmith
mesh_terms: D000073396:Metal-Organic Frameworks / Q000737:chemistry*; D008958:Models, Molecular; D053758:Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D036103:Nanotechnology / Q000379:methods; D010316:Particle Size; D016062:Porosity; D014027:Tobacco Mosaic Virus / Q000737:chemistry*; D014771:Virion / Q000737:chemistry*
chemical_list: D000073396:Metal-Organic Frameworks
keywords: bioconjugation reactions; metal-organic frameworks; nanoparticles; tobacco mosaic virus