title: Different Flavonoids Can Shape Unique Gut Microbiota Profile In Vitro.
abstract: The impact of flavonoids has been discussed on the relative viability of bacterial groups in human microbiota. This study was aimed to compare the modulation of various flavonoids, including quercetin, catechin and puerarin, on gut microbiota culture in vitro, and analyze the interactions between bacterial species using fructo-oligosaccharide (FOS) as carbon source under the stress of flavonoids. Three plant flavonoids, quercetin, catechin, and puerarin, were added into multispecies culture to ferment for 24 h, respectively. The bacterial 16S rDNA amplicons were sequenced, and the composition of microbiota community was analyzed. The results revealed that the tested flavonoids, quercetin, catechin, and puerarin, presented different activities of regulating gut microbiota; flavonoid aglycones, but not glycosides, may inhibit growth of certain species. Quercetin and catechin shaped unique biological webs. Bifidobacterium spp. was the center of the biological web constructed in this study.
authors.affiliation: Dept. of Food Science and Engineering, Jinan Univ, Guangzhou, 510630, China.
authors.forename: Jiacheng
authors.initials: J
authors.lastname: Huang
authors.affiliation: Dept. of Food Science and Engineering, Jinan Univ, Guangzhou, 510630, China.
authors.forename: Long
authors.initials: L
authors.lastname: Chen
authors.affiliation: Dept. of Food Science and Engineering, Jinan Univ, Guangzhou, 510630, China.
authors.forename: Bin
authors.initials: B
authors.lastname: Xue
authors.affiliation: Dept. of Food Science and Engineering, Jinan Univ, Guangzhou, 510630, China.
authors.forename: Qianyue
authors.initials: Q
authors.lastname: Liu
authors.affiliation: Dept. of Food Science and Engineering, Jinan Univ, Guangzhou, 510630, China.
authors.forename: Shiyi
authors.initials: S
authors.lastname: Ou
authors.affiliation: Dept. of Food Science and Engineering, Jinan Univ, Guangzhou, 510630, China.|Guangdong Engineering Research Center for Oil and Fat Biorefinery, Jinan Univ, Guangzhou, 510630, China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Dept. of Food Science and Engineering, Jinan Univ, Guangzhou, 510630, China. tpxchun@jnu.edu.cn.
authors.forename: Xichun
authors.initials: X
authors.lastname: Peng
mesh_terms: D001644:Bifidobacterium / Q000187:drug effects* / Q000235:genetics / Q000254:growth & development; D002392:Catechin / Q000494:pharmacology*; D005419:Flavonoids / Q000494:pharmacology*; D000069196:Gastrointestinal Microbiome / Q000187:drug effects*; D006027:Glycosides / Q000494:pharmacology; D006801:Humans; D007529:Isoflavones / Q000494:pharmacology*; D064307:Microbiota; D009844:Oligosaccharides; D010936:Plant Extracts / Q000494:pharmacology*; D011794:Quercetin / Q000494:pharmacology*; D012336:RNA, Ribosomal, 16S
chemical_list: D005419:Flavonoids; D006027:Glycosides; D007529:Isoflavones; D009844:Oligosaccharides; D010936:Plant Extracts; D012336:RNA, Ribosomal, 16S; D002392:Catechin; D011794:Quercetin; C033607:puerarin
keywords: Bifidobacteria; biological web; comparison; gut microbiota; polyphenols