title: Auditory evoked potential P300 in adults: reference values.
abstract: OBJECTIVE
  To establish reference intervals for cognitive potential P300 latency using tone burst stimuli.
  
  
  METHODS
  This study involved 28 participants aged between 18 and 59 years. P300 recordings were performed using a two-channel device (Masbe, Contronic). Electrode placement was as follows: Fpz (ground electrode), Cz (active electrode), M1 and M2 (reference electrodes). Intensity corresponded to 80 dB HL and frequent and rare stimulus frequencies to 1,000Hz and 2,000Hz, respectively. Stimuli were delivered binaurally.
  
  
  RESULTS
  Mean age of participants was 35 years. Average P300 latency was 305ms.
  
  
  CONCLUSIONS
  Maximum acceptable P300 latency values of 362.5ms (305 + 2SD 28.75) were determined for adults aged 18 to 59 years using the protocol described.
  
  
  OBJECTIVE
  Estabelecer valores de referência para a latência do potencial cognitivo P300 com estímulos tone burst.
  Participaram do estudo 28 indivíduos entre 18 e 59 anos. O registro do P300 foi realizado no equipamento Masbe da marca Contronic. Os eletrodos foram fixados nas posições Fpz (eletrodo terra), Cz (eletrodo ativo), M1 e M2 (eletrodos referência). A intensidade foi de 80 dB NA. A frequência do estímulo frequente foi de 1.000Hz e a do estímulo raro de 2.000Hz. Os estímulos foram apresentados na forma binaural.
  
  
  RESULTS
  A média de idade dos indivíduos foi de 35 anos. A média de latência para P300 de 305ms.
  Usando o protocolo descrito, o valor máximo de latência aceitáveis para P300 foram de 362,5ms (305 + 2DP 28,75) na faixa etária do adulto de 18 a 59 anos.
authors.affiliation: Universidade Federal de Santa Maria, Santa Maria, RS, Brazil.
authors.forename: Dayane Domeneghini
authors.initials: DD
authors.lastname: Didoné
authors.affiliation: Universidade Federal de Santa Maria, Santa Maria, RS, Brazil.
authors.forename: Michele Vargas
authors.initials: MV
authors.lastname: Garcia
authors.affiliation: Universidade Federal de Santa Maria, Santa Maria, RS, Brazil.
authors.forename: Sheila Jacques
authors.initials: SJ
authors.lastname: Oppitz
authors.affiliation: Universidade Federal de Santa Maria, Santa Maria, RS, Brazil.
authors.forename: Thalisson Francisco Finamôr da
authors.initials: TF
authors.lastname: Silva
authors.affiliation: Universidade Federal de Santa Maria, Santa Maria, RS, Brazil.
authors.forename: Sinéia Neujahr Dos
authors.initials: SN
authors.lastname: Santos
authors.affiliation: Universidade Federal de Santa Maria, Santa Maria, RS, Brazil.
authors.forename: Rúbia Soares
authors.initials: RS
authors.lastname: Bruno
authors.affiliation: Universidade Federal de Santa Maria, Santa Maria, RS, Brazil.
authors.forename: Valdete Alves Valentins Dos Santos
authors.initials: VA
authors.lastname: Filha
authors.affiliation: Universidade Federal de Santa Maria, Santa Maria, RS, Brazil.|Clínica Cóser, Santa Maria, RS, Brazil.
authors.forename: Pedro Luis
authors.initials: PL
authors.lastname: Cóser
mesh_terms: D000328:Adult; D018913:Event-Related Potentials, P300 / Q000502:physiology*; D005072:Evoked Potentials, Auditory / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011930:Reaction Time / Q000502:physiology; D012016:Reference Values; D055815:Young Adult