title: In Vitro Evaluation of the Activity of Imipenem-Relebactam against 451 Recent Clinical Isolates of Bacteroides Group and Related Species.
abstract: We evaluated the in vitro activity of imipenem-relebactam (imipenem-MK7655) against 451 recent clinical isolates within the Bacteroides group and related species. Relebactam did not enhance or inhibit the activity of imipenem against Bacteroides fragilis or other Bacteroides species. No synergistic or antagonistic effect was observed. The MICs of imipenem-relebactam were equal to or within one dilution of the MICs of these isolates to imipenem.
authors.affiliation: Department of Medicine, Tufts Medical Center and Tufts University School of Medicine, Boston, Massachusetts, USA dsnydman@tuftsmedicalcenter.org.
authors.forename: David R
authors.initials: DR
authors.lastname: Snydman
authors.affiliation: Department of Medicine, Tufts Medical Center and Tufts University School of Medicine, Boston, Massachusetts, USA.
authors.forename: Nilda V
authors.initials: NV
authors.lastname: Jacobus
authors.affiliation: Department of Medicine, Tufts Medical Center and Tufts University School of Medicine, Boston, Massachusetts, USA.
authors.forename: Laura A
authors.initials: LA
authors.lastname: McDermott
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D053961:Azabicyclo Compounds / Q000494:pharmacology*; D001439:Bacteroides / Q000187:drug effects* / Q000302:isolation & purification; D004357:Drug Synergism; D006801:Humans; D015378:Imipenem / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests
chemical_list: D000900:Anti-Bacterial Agents; D053961:Azabicyclo Compounds; D015378:Imipenem; C568736:relebactam