title: Testosterone and the Prostate: Artifacts and Truths.
abstract: Despite a lack of evidence, there have been stated concerns that testosterone replacement therapy (TRT) can pose a risk to men suffering with lower urinary tract symptoms (LUTS)/benign prostatic hyperplasia (BPH). TRT may improve components of the metabolic syndrome, which is associated with worsening LUTS. Furthermore, the evidence suggests that TRT may decrease prostatic inflammation, which is also associated with worsening LUTS. The data on the relationship between TRT and LUTS have never shown worsening of LUTS, often show no change in LUTS, and occasionally show improvement.
authors.affiliation: Departments of Urology, Tulane University Health Sciences Center, New Orleans, LA, USA.
authors.forename: Kenneth Jackson
authors.initials: KJ
authors.lastname: DeLay
authors.affiliation: Division of Urology, Southern Illinois University School of Medicine, 301 North 8th Street, 4th Floor, PO Box 19665, Springfield, IL 62794-9665, USA. Electronic address: tkohler@siumed.edu.
authors.forename: Tobias S
authors.initials: TS
authors.lastname: Kohler
mesh_terms: D016477:Artifacts; D006801:Humans; D059411:Lower Urinary Tract Symptoms / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology; D008297:Male; D011467:Prostate / Q000187:drug effects*; D011470:Prostatic Hyperplasia / Q000150:complications / Q000188:drug therapy*; D012307:Risk Factors; D013739:Testosterone / Q000009:adverse effects / Q000627:therapeutic use*
chemical_list: D013739:Testosterone
keywords: BPH; Hypogonadism; LUTS; Testosterone