title: Mouse and Cotton Rat Models of Human Respiratory Syncytial Virus.
abstract: Human respiratory syncytial virus (hRSV) is a common respiratory virus that is usually no cause for alarm. Symptoms of hRSV usually resemble those of the common cold and can go undiagnosed. However, infants as well as the elderly are at risk for developing severe cases, which can lead to high morbidity and mortality rates especially if there are underlying health issues. Despite many years of effort, no vaccine or specific treatments exist and RSV is still the leading cause of infant hospitalizations worldwide. Here, we describe methods to infect two widely used small animal models: laboratory mice and cotton rats.
authors.affiliation: Emerging Viruses and Inflammation Research Group, Institute for Glycomics, Griffith University, Gold Coast Campus, Southport, QLD, 4222, Australia.
authors.forename: Penny A
authors.initials: PA
authors.lastname: Rudd
authors.affiliation: Emerging Viruses and Inflammation Research Group, Institute for Glycomics, Griffith University, Gold Coast Campus, Southport, QLD, 4222, Australia.
authors.forename: Weiqiang
authors.initials: W
authors.lastname: Chen
authors.affiliation: Emerging Viruses and Inflammation Research Group, Institute for Glycomics, Griffith University, Gold Coast Campus, Southport, QLD, 4222, Australia. s.mahalingam@griffith.edu.au.
authors.forename: Suresh
authors.initials: S
authors.lastname: Mahalingam
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D006801:Humans; D051379:Mice; D018357:Respiratory Syncytial Virus Infections / Q000821:virology*; D018113:Respiratory Syncytial Virus, Human / Q000254:growth & development / Q000502:physiology*; D016205:Sigmodontinae / Q000821:virology*; D019562:Viral Load; D010948:Viral Plaque Assay; D014779:Virus Replication
keywords: Human respiratory syncytial virus; In vivo infections; Methodology; Propagation; Titration