title: Biosynthesis of polyamines and polyamine-containing molecules.
abstract: Polyamines are evolutionarily ancient polycations derived from amino acids and are pervasive in all domains of life. They are essential for cell growth and proliferation in eukaryotes and are essential, important or dispensable for growth in bacteria. Polyamines present a useful scaffold to attach other moieties to, and are often incorporated into specialized metabolism. Life has evolved multiple pathways to synthesize polyamines, and structural variants of polyamines have evolved in bacteria, archaea and eukaryotes. Among the complex biosynthetic diversity, patterns of evolutionary reiteration can be distinguished, revealing evolutionary recycling of particular protein folds and enzyme chassis. The same enzyme activities have evolved from multiple protein folds, suggesting an inevitability of evolution of polyamine biosynthesis. This review discusses the different biosynthetic strategies used in life to produce diamines, triamines, tetra-amines and branched and long-chain polyamines. It also discusses the enzymes that incorporate polyamines into specialized metabolites and attempts to place polyamine biosynthesis in an evolutionary context.
authors.affiliation: Department of Pharmacology, University of Texas Southwestern Medical Center, 6001 Forest Park, Dallas, TX 75390, U.S.A. anthony.michael@utsouthwestern.edu.
authors.forename: Anthony J
authors.initials: AJ
authors.lastname: Michael
mesh_terms: D000818:Animals; D001105:Archaea / Q000378:metabolism; D001419:Bacteria / Q000378:metabolism; D005075:Biological Evolution; D006801:Humans; D011073:Polyamines / Q000378:metabolism*
chemical_list: D011073:Polyamines
keywords: biosynthetic diversity; convergent evolution; polyamine; putrescine; spermidine; spermine