title: The Role of Vitamin D Receptor Polymorphisms on Dental Caries.
abstract: OBJECTIVE
  To determine the association between the ApaI, FokI, Cdx2 and TaqI polymorphisms of vitamin D receptor (VDR) gene in caries-active (high-moderate) and caries-free children.
  
  
  METHODS
  A hundred and fifty children (75 males, 75 females, mean age: 10.19 ± 1.61 years) were included in the study. The subjects were divided into three groups as high caries risk group (DMFT, dft>4)(n=55), moderate caries risk group (DMFT, dft=1-4)(n=57) and caries-free group (n=38). From each individual, blood samples were collected and DNA was extracted. The VDR gene was genotyped for the polymorphisms ApaI, FokI, Cdx2 and TaqI using polymerase chain reaction and restriction fragment length polymorphism methods. All data were analyzed by chi-square test, Fisher's exact test and t test.
  
  
  RESULTS
  There was statistically significant difference in the frequency of TaqI genotypes (tt) between caries-active and caries-free children (p=0.029). No statistically significant differences were detected between ApaI, FokI, Cdx2 genotypes and dental caries.
  
  
  CONCLUSIONS
  In the future, VDR gene polymorphisms may be used as a marker for the identification of patients with high caries risk.
authors.forename: Dilsah
authors.initials: D
authors.lastname: Cogulu
authors.forename: Huseyin
authors.initials: H
authors.lastname: Onay
authors.forename: Yasemin
authors.initials: Y
authors.lastname: Ozdemir
authors.forename: Gulcin Itirli
authors.initials: GI
authors.lastname: Aslan
authors.forename: Ferda
authors.initials: F
authors.lastname: Ozkinay
authors.forename: Cemal
authors.initials: C
authors.lastname: Eronat
mesh_terms: D000071616:CDX2 Transcription Factor / Q000235:genetics; D002648:Child; D003731:Dental Caries / Q000235:genetics*; D003774:Dental Plaque Index; D015252:Deoxyribonucleases, Type II Site-Specific / Q000235:genetics; D019422:Dietary Sucrose / Q000008:administration & dosage; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000235:genetics; D005838:Genotype; D006801:Humans; D008297:Male; D011110:Polymorphism, Genetic / Q000235:genetics*; D012150:Polymorphism, Restriction Fragment Length / Q000235:genetics; D018167:Receptors, Calcitriol / Q000235:genetics*; D014099:Toothbrushing / Q000379:methods; D014157:Transcription Factors / Q000235:genetics
chemical_list: D000071616:CDX2 Transcription Factor; C491270:CDX2 protein, human; D019422:Dietary Sucrose; D018167:Receptors, Calcitriol; D014157:Transcription Factors; C467905:ZNF410 protein, human; C035042:endodeoxyribonuclease FokI; D015252:Deoxyribonucleases, Type II Site-Specific; C027046:TCGA-specific type II deoxyribonucleases
keywords: Vitamin D receptor; dental caries; polymorphism