title: Tumor relapse prevented by combining adoptive T cell therapy with Salmonella typhimurium.
abstract: We recently reported that therapeutic vaccination with live tumor antigen-producing Salmonella typhimurium rescues dysfunctional endogenous T cell responses and eradicates long-established tumors refractory to αCTLA-4 and αPD-L1 checkpoint inhibitor blockade. Here, we show that live intravenously injected or heat-killed (HK) intratumorally injected Salmonella typhimurium, even when not producing tumor antigen, synergize with adoptive T cell therapy to eradicate tumors. These data demonstrate that the combination of adoptive T cell transfer with the injection of live or dead Salmonella typhimurium is a promising approach for cancer treatment.
authors.affiliation: Committee on Cancer Biology, University of Chicago, Chicago, IL, USA; Department of Pathology, University of Chicago, Chicago, IL, USA.
authors.forename: David C
authors.initials: DC
authors.lastname: Binder
authors.affiliation: Department of Pathology, University of Chicago, Chicago, IL, USA; Committee on Immunology, The University of Chicago, Chicago, IL, USA.
authors.forename: Ainhoa
authors.initials: A
authors.lastname: Arina
authors.affiliation: Department of Pathology, University of Chicago , Chicago, IL, USA.
authors.forename: Frank
authors.initials: F
authors.lastname: Wen
authors.affiliation: Department of Pathology, University of Chicago, Chicago, IL, USA; Committee on Immunology, The University of Chicago, Chicago, IL, USA.
authors.forename: Tony
authors.initials: T
authors.lastname: Tu
authors.affiliation: AntiCancer Inc. , San Diego, CA, USA.
authors.forename: Ming
authors.initials: M
authors.lastname: Zhao
authors.affiliation: AntiCancer Inc., San Diego, CA, USA; Department of Surgery, University of California, San Diego, CA, USA.
authors.forename: Robert M
authors.initials: RM
authors.lastname: Hoffman
authors.affiliation: Department of Neurological Surgery, Northwestern University Feinberg School of Medicine, Chicago, IL, USA; Northwestern Brain Tumor Institute, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
authors.forename: Derek A
authors.initials: DA
authors.lastname: Wainwright
authors.affiliation: Committee on Cancer Biology, University of Chicago, Chicago, IL, USA; Department of Pathology, University of Chicago, Chicago, IL, USA; Committee on Immunology, The University of Chicago, Chicago, IL, USA.
authors.forename: Hans
authors.initials: H
authors.lastname: Schreiber
keywords: Adoptive T cell therapy; bacteria; macrophage; relapse; tumor stroma