title: [Oxidative stress and antioxitant therapy of chronic periodontitis].
abstract: Chronic periodontitis is a progressive, infectious inflammation disease, caused by the dysbiosis of oral resident flora, leading to the destruction of periodontium. The onset of pathogenic microorganisms is the etiological factor of periodontitis, while the immuno-inflammatory response affects the progression of the disease. Under chronic periodontitis, oxidative stress occurs when excessive reactive oxygen species are produced and exceed the compensative capacity of the organism. Oxidative stress leads to the destruction of periodontium, in a direct way(damaging the biomolecule) or an indirect way(enhancing the produce of inflammatory cytokine and destructive enzymes). Therefore, as the antagonist of the reactive oxygen species, antioxidants may be helpful to treat the chronic periodontitis. This paper reviewed relevant literatures about the destructive role of excessive reactive oxygen species and protective role of antioxidants in chronic periodontitis.
authors.affiliation: State Key Laboratory of Oral Diseases, Sichuan University, Chengdu 610041, China.
authors.forename: Y X
authors.initials: YX
authors.lastname: Shen
authors.affiliation: State Key Laboratory of Oral Diseases, Sichuan University, Chengdu 610041, China.
authors.forename: S J
authors.initials: SJ
authors.lastname: Guo
authors.affiliation: State Key Laboratory of Oral Diseases, Sichuan University, Chengdu 610041, China.
authors.forename: Y F
authors.initials: YF
authors.lastname: Wu
mesh_terms: D000975:Antioxidants / Q000627:therapeutic use*; D055113:Chronic Periodontitis / Q000209:etiology / Q000382:microbiology / Q000628:therapy*; D016207:Cytokines / Q000378:metabolism; D006801:Humans; D018384:Oxidative Stress; D010519:Periodontium; D017382:Reactive Oxygen Species / Q000037:antagonists & inhibitors*
chemical_list: D000975:Antioxidants; D016207:Cytokines; D017382:Reactive Oxygen Species