title: [Induced pluripotent stem cells revolutionise research of neurodegenerative diseases].
abstract: Research into the causes of neurodegenerative diseases like Parkinson's- and Alzheimer's disease has long been hampered by the lack of access to live disease-afflicted neurons for in vitro studies. The introduction of induced pluripotent stem (iPS) cells has made such studies possible. iPS cells can be reprogrammed from somatic patient-derived cells (e.g. skin cells) and differentiated into any cell type of the body. This allows for the production of neurons, which have the genetic background of the patients and show disease-relevant phenotypes.
authors.affiliation: mmeyer@health.sdu.dk.
authors.forename: Sissel Ida
authors.initials: SI
authors.lastname: Schmidt
authors.forename: Matias Jul
authors.initials: MJ
authors.lastname: Knudsen
authors.forename: Helle Bogetofte
authors.initials: HB
authors.lastname: Barnkob
authors.forename: Morten
authors.initials: M
authors.lastname: Meyer
mesh_terms: D035843:Biomedical Research / Q000639:trends; D002454:Cell Differentiation; D000067470:Cellular Reprogramming Techniques; D005347:Fibroblasts / Q000378:metabolism; D006801:Humans; D057026:Induced Pluripotent Stem Cells / Q000378:metabolism*; D019636:Neurodegenerative Diseases / Q000378:metabolism / Q000628:therapy