title: Multivalent Interactions between an Aromatic Helical Foldamer and a DNA G-Quadruplex in the Solid State.
abstract: Quinoline-based oligoamide foldamers have been identified as a potent class of ligands for G-quadruplex DNA. Their helical structure is thought to target G-quadruplex loops or grooves and not G-tetrads. We report a co-crystal structure of the antiparallel hairpin dimeric DNA G-quadruplex (G4T4G4)2with tetramer 1-a helically folded oligo-quinolinecarboxamide bearing cationic side chains-that is consistent with this hypothesis. Multivalent foldamer-DNA interactions that modify the packing of (G4T4G4)2in the solid state are observed.
authors.affiliation: University of Bordeaux, CBMN, UMR 5248), Institut Européen de Chimie et Biologie, 2 rue Escarpit, 33600, Pessac, France.|CNRS, CBMN, UMR 5248), 2 rue Escarpit, 33600, Pessac, France.|Bordeaux Institut National Polytechnique, CBMN, UMR 5248), 2 rue Escarpit, 33600, Pessac, France.
authors.forename: Pradeep K
authors.identifier: 0000-0001-5996-956X
authors.initials: PK
authors.lastname: Mandal
authors.affiliation: University of Bordeaux, CBMN, UMR 5248), Institut Européen de Chimie et Biologie, 2 rue Escarpit, 33600, Pessac, France.|CNRS, CBMN, UMR 5248), 2 rue Escarpit, 33600, Pessac, France.|Bordeaux Institut National Polytechnique, CBMN, UMR 5248), 2 rue Escarpit, 33600, Pessac, France.
authors.forename: Benoît
authors.initials: B
authors.lastname: Baptiste
authors.affiliation: University of Bordeaux, CBMN, UMR 5248), Institut Européen de Chimie et Biologie, 2 rue Escarpit, 33600, Pessac, France.|CNRS, CBMN, UMR 5248), 2 rue Escarpit, 33600, Pessac, France.|Bordeaux Institut National Polytechnique, CBMN, UMR 5248), 2 rue Escarpit, 33600, Pessac, France.
authors.forename: Béatrice
authors.initials: B
authors.lastname: Langlois d'Estaintot
authors.affiliation: University of Bordeaux, IECB, UMS 3033), Institut Européen de Chimie et Biologie, 2 rue Escarpit, 33600, Pessac, France.|CNRS, IECB, UMS 3033), 2 rue Escarpit, 33600, Pessac, France.|INSERM, IECB, US001), 2 rue Escarpit, 33600, Pessac, France.
authors.forename: Brice
authors.identifier: 0000-0002-2932-3255
authors.initials: B
authors.lastname: Kauffmann
authors.affiliation: University of Bordeaux, CBMN, UMR 5248), Institut Européen de Chimie et Biologie, 2 rue Escarpit, 33600, Pessac, France. i.huc@iecb.u-bordeaux.fr.|CNRS, CBMN, UMR 5248), 2 rue Escarpit, 33600, Pessac, France. i.huc@iecb.u-bordeaux.fr.|Bordeaux Institut National Polytechnique, CBMN, UMR 5248), 2 rue Escarpit, 33600, Pessac, France. i.huc@iecb.u-bordeaux.fr.
authors.forename: Ivan
authors.identifier: 0000-0001-7036-9696
authors.initials: I
authors.lastname: Huc
mesh_terms: D000577:Amides / Q000737:chemistry*; D018360:Crystallography, X-Ray; D016054:DNA, Protozoan / Q000737:chemistry*; D054856:G-Quadruplexes; D008024:Ligands; D008958:Models, Molecular; D008968:Molecular Conformation; D016813:Oxytricha / Q000737:chemistry; D011804:Quinolines / Q000737:chemistry*
chemical_list: D000577:Amides; D016054:DNA, Protozoan; D008024:Ligands; D011804:Quinolines; C037219:quinoline
keywords: DNA ligands; DNA structures; G-quadruplexes; foldamers; solid-state interactions