title: Narrowing Resection of Parametrial Tissues Is Feasible in Low-Risk Cases of Stage IA2-IB1 Cervical Cancer.
abstract: BACKGROUND
  Radical hysterectomy with pelvic lymphadenectomy is the standard surgical treatment for patients with stage IA2-IB1 cervical cancer, but the wide excision increases the complications.
  
  
  OBJECTIVE
  To analyze the feasibility of narrowing resection of parametrial tissues in stage IA2-IB1 cervical cancer.
  
  
  METHODS
  Retrospectively analyzed the pathological and clinical data of patients with stage IA2-IB1 cervical cancer who received radical hysterectomy with pelvic lymphadenectomy in OB/GYN Hospital, Fudan University, China from Jan 2008 to Dec 2011. The affected factors of parametrial metastases and outcomes were discussed. The single factor analysis was made with χ2 test, and the relationship of the resection width of parametrial tissues and the patients' outcomes was analyzed with χ2 test and log-rank. P-values <0.05 were considered statistically significant.
  
  
  RESULTS
  There were 31 cases recurred, 26 cases died of cervical cancer in 513 patients during the follow-up period (from 2 months to 66 months, averaged 39 months). The low-risk factors included diameter of tumor ≤2cm, depth of cervical myometrial invasion<1/2 and without lymph vascular involvement. There were no parametrial metastases in cases with all three low-risk factors. Whether the resection width of parametrial tissues ≥3cm or not had no statistically significant effect on progression free survival (PFS) or overall survival (OS) of low-risk patients. D2-40 and CD31 were related with parametrial metastases, but not with recurrence or outcomes.
  
  
  CONCLUSIONS
  The resection width of parametrial tissues has no effect on PFS and OS of low-risk patients, and narrowing resection of parametrial tissues (<3cm) is feasible.
authors.affiliation: 1. Department of Gynecology, OB/GYN Hospital, Fudan University, Shanghai, China;; 2. Shanghai Key Laboratory of Female Reproductive Endocrine-Related Diseases, Shanghai, China.
authors.forename: Xue-Lian
authors.initials: XL
authors.lastname: Li
authors.affiliation: 1. Department of Gynecology, OB/GYN Hospital, Fudan University, Shanghai, China;; 2. Shanghai Key Laboratory of Female Reproductive Endocrine-Related Diseases, Shanghai, China.
authors.forename: Xiao-Xia
authors.initials: XX
authors.lastname: Liu
authors.affiliation: 1. Department of Gynecology, OB/GYN Hospital, Fudan University, Shanghai, China;
authors.forename: Guan-Shu
authors.initials: GS
authors.lastname: Cao
authors.affiliation: 1. Department of Gynecology, OB/GYN Hospital, Fudan University, Shanghai, China;
authors.forename: Dan-Dan
authors.initials: DD
authors.lastname: Ju
authors.affiliation: 1. Department of Gynecology, OB/GYN Hospital, Fudan University, Shanghai, China;; 2. Shanghai Key Laboratory of Female Reproductive Endocrine-Related Diseases, Shanghai, China.
authors.forename: Hua
authors.initials: H
authors.lastname: Jiang
keywords: low-risk factors; narrowing resection of parametrial tissues.; parametrial metastases; stage IA2-IB1 cervical cancer