title: A Powerful DREADD: Revealing Structural Drivers of Functional Dynamics.
abstract: In this issue of Neuron, Grayson et al. (2016) report how inhibition of amygdala impacts amygdalocortical and corticocortical functional connectivity. Their study predicts changes in functional brain topology, induced by pharmacologic modulation of neuroanatomical circuits using designer receptors exclusively activated by designer drugs (DREADDs), through virtual lesioning of amygdala in structural brain networks.
authors.affiliation: Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104, USA.
authors.forename: Ankit N
authors.initials: AN
authors.lastname: Khambhati
authors.affiliation: Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Electrical and Systems Engineering, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address: dsb@seas.upenn.edu.
authors.forename: Danielle S
authors.initials: DS
authors.lastname: Bassett
mesh_terms: D000818:Animals; D001519:Behavior / Q000502:physiology; D001921:Brain / Q000502:physiology*; D003198:Computer Simulation; D006801:Humans; D009415:Nerve Net / Q000502:physiology*; D009474:Neurons / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology*
keywords: DREADDs; functional brain network; network neuroscience; structural brain network; virtual lesioning