title: A Tale of Two Joints: The Role of Matrix Metalloproteases in Cartilage Biology.
abstract: Matrix metalloproteinases are a class of enzymes involved in the degradation of extracellular matrix molecules. While these molecules are exceptionally effective mediators of physiological tissue remodeling, as occurs in wound healing and during embryonic development, pathological upregulation has been implicated in many disease processes. As effectors and indicators of pathological states, matrix metalloproteinases are excellent candidates in the diagnosis and assessment of these diseases. The purpose of this review is to discuss matrix metalloproteinases as they pertain to cartilage health, both under physiological circumstances and in the instances of osteoarthritis and rheumatoid arthritis, and to discuss their utility as biomarkers in instances of the latter.
authors.affiliation: Department of Physiology and Developmental Biology, Brigham Young University (BYU), LSB 4005, Provo, UT 84602, USA.
authors.forename: Brandon J
authors.identifier: 0000-0002-9396-1198
authors.initials: BJ
authors.lastname: Rose
authors.affiliation: Department of Physiology and Developmental Biology, Brigham Young University (BYU), LSB 4005, Provo, UT 84602, USA.
authors.forename: David L
authors.identifier: 0000-0001-6090-4384
authors.initials: DL
authors.lastname: Kooyman
mesh_terms: D001172:Arthritis, Rheumatoid / Q000378:metabolism / Q000473:pathology*; D015415:Biomarkers / Q000378:metabolism*; D002356:Cartilage / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D020782:Matrix Metalloproteinases / Q000378:metabolism*; D010003:Osteoarthritis / Q000378:metabolism / Q000473:pathology*
chemical_list: D015415:Biomarkers; D020782:Matrix Metalloproteinases