title: Tocilizumab improved clinical symptoms of a patient with systemic tophaceous gout who had symmetric polyarthritis and fever: An alternative treatment by blockade of interleukin-6 signaling.
abstract: Chronic tophaceous gout is the end stage of gout. We employed a blockade of interleukin-6 signaling therapy by tocilizumab instead of anakinra, an interleukin-1 receptor antagonist, for a 61-year-old Japanese woman diagnosed with tophaceous gout. Laboratory data showed that serum interleukin-6 concentration was elevated. Serum interleukin-1β concentration was under the detectable level, although serum uric acid was elevated due to renal dysfunction. The secretion patterns of interleukin-1β, tumor-necrosis factor-α, interleukin-6, and interleukin-8 from peripheral mononuclear cells isolated from the patient exhibited no remarkable differences compared with those of healthy volunteers. After treatment with the interleukin-6 receptor antagonist tocilizumab, serum interleukin-6 concentration decreased followed by improved clinical symptoms, such as reduced size of the subcutaneous nodules, no fever, and no acute gouty attacks during the treatment. Our case suggests that tocilizumab markedly improves clinical and laboratory manifestations in tophaceous gout with arthritis and fever as well as interleukin-1 blockade therapy.
authors.affiliation: Department of Pathology, Ehime University Proteo-Science Centre and Graduate School of Medicine, Shitsukawa 454, Toon, Ehime, 791-0295 Japan; Department of Immunology, Graduate School of Medicine, Hiroshima University, Hiroshima, 734-8551, Japan; Centre for Rheumatic Diseases, Dogo Spa Hospital, Matsuyama, Ehime, 790-0858, Japan.
authors.forename: Sho
authors.initials: S
authors.lastname: Mokuda
authors.affiliation: Department of Immunology, Graduate School of Medicine, Hiroshima University, Hiroshima, 734-8551, Japan.
authors.forename: Masamoto
authors.initials: M
authors.lastname: Kanno
authors.affiliation: Centre for Rheumatic Diseases, Dogo Spa Hospital, Matsuyama, Ehime, 790-0858, Japan.
authors.forename: Kiyoshi
authors.initials: K
authors.lastname: Takasugi
authors.affiliation: Department of Pathology, Ehime University Proteo-Science Centre and Graduate School of Medicine, Shitsukawa 454, Toon, Ehime, 791-0295 Japan.
authors.forename: Chikara
authors.initials: C
authors.lastname: Okumura
authors.affiliation: Department of Pathology, Ehime University Proteo-Science Centre and Graduate School of Medicine, Shitsukawa 454, Toon, Ehime, 791-0295 Japan.
authors.forename: Yuki
authors.initials: Y
authors.lastname: Ito
authors.affiliation: Department of Pathology, Ehime University Proteo-Science Centre and Graduate School of Medicine, Shitsukawa 454, Toon, Ehime, 791-0295 Japan.
authors.forename: Junya
authors.initials: J
authors.lastname: Masumoto
keywords: Tophaceous gout; inflammasome; interleukin-1β; interleukin-6; tocilizumab