title: Pharmacotherapy & Surgical Interventions Available for Obesity Management and Importance of Pancreatic Lipase Inhibitory Phytomolecules as Safer Anti-Obesity Therapeutics.
abstract: The humans worldwide are facing obesity as a major clinical threat because it is linked with cardiovascular diseases which often have serious consequences. Treatments available for body weight loss do not produce permanent weight loss and they often bear some side effects. To achieve safer antiobesetic therapeutics, researchers are moving towards plant-based therapeutic formulations. Many phytomolecules have been identified as anti-lipolytic functions but none of them have reached up to the clinical level. So there is an essential need to develop effective anti-obesetic medications which not only produce sufficient weight loss but also lack side effects. Plants may prove promising option for the same. In this article, medications and surgical procedures have been reviewed and dealt for weight loss and the role of phytomolecules in anti-obesetic therapeutics has been explored.
authors.forename: Singh
authors.initials: S
authors.lastname: Sukhdev
authors.forename: Sharma
authors.initials: S
authors.lastname: Bhupender
authors.affiliation: Department of Biotechnology, Himachal Pradesh University, Summer Hill, Shimla-171 005, India.
authors.forename: Kanwar Shamsher
authors.initials: KS
authors.lastname: Singh
mesh_terms: D019440:Anti-Obesity Agents / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use*; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use*; D006801:Humans; D008049:Lipase / Q000037:antagonists & inhibitors* / Q000378:metabolism; D015394:Molecular Structure; D009765:Obesity / Q000188:drug therapy* / Q000378:metabolism / Q000601:surgery*
chemical_list: D019440:Anti-Obesity Agents; D004791:Enzyme Inhibitors; D008049:Lipase; C518354:PNLIP protein, human