title: Hesperidin and tiger nut reduced carcinogenicity of DMBA in female rats.
abstract: Nutritional studies recommend the regular consumption of fruits and vegetables to favor a healthy quality of life. This study was carried out to evaluate the efficacy of hesperidin and tiger nut against the carcinogenic activity of DMBA in female rats. 72 adult Sprague Dawley female rats were divided equally into six groups: control group (I); Hesperidin treated group (II); Tiger Nut treated group (III); DMBA treated group (IV); HES-DMBA treated group (V); and TN-DMBA treated group (VI). There was a significant increase in serum levels of carcinoembryonic antigen, total sialic acid, progesterone, estradiol, ALT, AST, LDH, urea and creatinine, and significant decrease in reduced glutathione level, superoxide dismutase, catalase and glutathione peroxidase activities of DMBA treated group compared to control. In conclusion, our results suggested that supplementation of diets with hesperidin provided antioxidant and chemoprotective activities more significant than tiger nut against the toxicity of DMBA in breast, liver and kidney tissues.
authors.affiliation: Chemistry Department, Biochemistry division, Faculty of Science, El Fayoum University, El- Fayoum, Egypt.
authors.forename: Soha M
authors.initials: SM
authors.lastname: Hamdy
authors.affiliation: Chemistry Department, Biochemistry division, Faculty of Science, El Fayoum University, El- Fayoum, Egypt. Electronic address: ons00@fayoum.edu.eg.
authors.forename: Ola N
authors.initials: ON
authors.lastname: Sayed
authors.affiliation: Zoology Department, Faculty of Science, El Fayoum University, El- Fayoum, Egypt.
authors.forename: Abdel Karim M
authors.initials: AKM
authors.lastname: Abdel Latif
authors.affiliation: Zoology Department, Faculty of Science, El Fayoum University, El- Fayoum, Egypt.
authors.forename: Ayman M
authors.initials: AM
authors.lastname: Abdel-Aziz
authors.affiliation: Chemistry Department, Biochemistry division, Faculty of Science, El Fayoum University, El- Fayoum, Egypt.
authors.forename: Alshimaa M
authors.initials: AM
authors.lastname: Amin
mesh_terms: D015127:9,10-Dimethyl-1,2-benzanthracene; D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D001835:Body Weight / Q000187:drug effects; D063646:Carcinogenesis / Q000378:metabolism / Q000473:pathology*; D002374:Catalase / Q000378:metabolism; D029786:Cyperus / Q000737:chemistry*; D004958:Estradiol / Q000097:blood; D005260:Female; D005979:Glutathione Peroxidase / Q000378:metabolism; D006569:Hesperidin / Q000494:pharmacology / Q000627:therapeutic use*; D007668:Kidney / Q000187:drug effects / Q000473:pathology; D008099:Liver / Q000187:drug effects / Q000473:pathology; D008315:Malondialdehyde / Q000097:blood; D008321:Mammary Glands, Animal / Q000187:drug effects / Q000473:pathology; D019158:N-Acetylneuraminic Acid / Q000097:blood; D011374:Progesterone / Q000097:blood; D050050:Protein Carbonylation / Q000187:drug effects; D017207:Rats, Sprague-Dawley; D013482:Superoxide Dismutase / Q000378:metabolism
chemical_list: D011374:Progesterone; D004958:Estradiol; D008315:Malondialdehyde; D015127:9,10-Dimethyl-1,2-benzanthracene; D006569:Hesperidin; D002374:Catalase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D019158:N-Acetylneuraminic Acid
keywords: CEA; DMBA; Estradiol; Hesperidin; Progesterone; Tiger nut