title: RuvB-Like Protein 2 (Ruvbl2) Has a Role in Directing the Neuroectodermal Differentiation of Mouse Embryonic Stem Cells.
abstract: Although many factors have been identified to be involved in the development of the neuroectoderm during embryogenesis, it is still important to identify novel factors that convert undifferentiated embryonic cells into neuroectoderm. RuvB-like protein 2 (Ruvbl2) is known to regulate gene expression via chromatin remodeling by participating in multi-protein complexes, but its role during embryonic development is not well known. In this study, we established Ruvbl2-overexpressing mouse embryonic stem cells and examined their capacity to specifically differentiate into neuroectoderm and confirmed the specific expression of RUVBL2 in early embryonic neuroectoderm. Our results suggest that Ruvbl2 has a role in the differentiation of neuroectoderm during early embryogenesis.
authors.affiliation: 1 Department of Biomedical Science, College of Life Science, CHA University , Seongnam, Korea.
authors.forename: Soomin
authors.initials: S
authors.lastname: Hong
authors.affiliation: 1 Department of Biomedical Science, College of Life Science, CHA University , Seongnam, Korea.
authors.forename: Junghyun
authors.initials: J
authors.lastname: Jo
authors.affiliation: 2 Fertility Center, CHA Gangnam Medical Center, College of Medicine, CHA University , Seoul, Korea.
authors.forename: Hyung Joon
authors.initials: HJ
authors.lastname: Kim
authors.affiliation: 3 CHA Stem Cell Institute, CHA University , Seoul, Korea.
authors.forename: Jeoung Eun
authors.initials: JE
authors.lastname: Lee
authors.affiliation: 2 Fertility Center, CHA Gangnam Medical Center, College of Medicine, CHA University , Seoul, Korea.
authors.forename: Dong Hyuk
authors.initials: DH
authors.lastname: Shin
authors.affiliation: 3 CHA Stem Cell Institute, CHA University , Seoul, Korea.
authors.forename: Sung-Geum
authors.initials: SG
authors.lastname: Lee
authors.affiliation: 2 Fertility Center, CHA Gangnam Medical Center, College of Medicine, CHA University , Seoul, Korea.
authors.forename: Ahmi
authors.initials: A
authors.lastname: Baek
authors.affiliation: 1 Department of Biomedical Science, College of Life Science, CHA University , Seongnam, Korea.|2 Fertility Center, CHA Gangnam Medical Center, College of Medicine, CHA University , Seoul, Korea.
authors.forename: Sung Han
authors.initials: SH
authors.lastname: Shim
authors.affiliation: 1 Department of Biomedical Science, College of Life Science, CHA University , Seongnam, Korea.|2 Fertility Center, CHA Gangnam Medical Center, College of Medicine, CHA University , Seoul, Korea.|3 CHA Stem Cell Institute, CHA University , Seoul, Korea.
authors.forename: Dong Ryul
authors.initials: DR
authors.lastname: Lee
mesh_terms: D000074183:ATPases Associated with Diverse Cellular Activities; D000818:Animals; D015415:Biomarkers / Q000378:metabolism; D002454:Cell Differentiation / Q000235:genetics*; D049109:Cell Proliferation; D004265:DNA Helicases / Q000235:genetics / Q000378:metabolism*; D058732:Embryoid Bodies / Q000166:cytology / Q000378:metabolism; D005333:Fetus / Q000378:metabolism; D020869:Gene Expression Profiling; D018507:Gene Expression Regulation, Developmental; D051379:Mice; D008810:Mice, Inbred C57BL; D000066450:Mouse Embryonic Stem Cells / Q000166:cytology* / Q000378:metabolism*; D054258:Neural Plate / Q000166:cytology*; D038081:Organogenesis / Q000235:genetics; D015854:Up-Regulation / Q000235:genetics
chemical_list: D015415:Biomarkers; D000074183:ATPases Associated with Diverse Cellular Activities; D004265:DNA Helicases; C518330:RUVBL2 protein, mouse