title: Characterization of p75 neurotrophin receptor expression in human dental pulp stem cells.
abstract: Human adult dental pulp stem cells (DPSC) are a heterogeneous stem cell population, which are able to differentiate down neural, chondrocyte, osteocyte and adipocyte lineages. We studied the expression pattern of p75 neurotrophin receptors (p75NTR), a marker of neural stem cells, within human DPSC populations from eight donors. p75NTR are expressed at low levels (<10%) in DPSC. Importantly, p75(+) DPSC represent higher expression levels of SOX1 (neural precursor cell marker), SOX2 (cell pluripotency marker) and nestin (neural stem cell marker) in comparison to p75(-) DPSC. Our results suggest that p75(+) hDPSC may denote a subpopulation with greater neurogenic potential.
authors.affiliation: School of Medical Science, Australia; South Australian Health & Medical Research Institute, South Australia, Australia.
authors.forename: Wenru
authors.initials: W
authors.lastname: Pan
authors.affiliation: School of Medicine, Australia; South Australian Health & Medical Research Institute, South Australia, Australia.
authors.forename: Karlea L
authors.initials: KL
authors.lastname: Kremer
authors.affiliation: School of Medicine, Australia; South Australian Health & Medical Research Institute, South Australia, Australia.
authors.forename: Xenia
authors.initials: X
authors.lastname: Kaidonis
authors.affiliation: School of Medicine, Australia; South Australian Health & Medical Research Institute, South Australia, Australia.
authors.forename: Victoria E
authors.initials: VE
authors.lastname: Ludlow
authors.affiliation: Human Physiology, Centre for Neuroscience, School of Medicine, Flinders University, Australia.
authors.forename: Mary-Louise
authors.initials: ML
authors.lastname: Rogers
authors.affiliation: South Australian Health & Medical Research Institute, South Australia, Australia.
authors.forename: Jianling
authors.initials: J
authors.lastname: Xie
authors.affiliation: School of Biological Sciences, University of Adelaide, Australia; South Australian Health & Medical Research Institute, South Australia, Australia.
authors.forename: Christopher G
authors.initials: CG
authors.lastname: Proud
authors.affiliation: School of Medicine, Australia; South Australian Health & Medical Research Institute, South Australia, Australia. Electronic address: simon.koblar@adelaide.edu.au.
authors.forename: Simon A
authors.initials: SA
authors.lastname: Koblar
mesh_terms: D002454:Cell Differentiation / Q000502:physiology; D002478:Cells, Cultured; D003782:Dental Pulp / Q000166:cytology*; D005434:Flow Cytometry; D006801:Humans; D009419:Nerve Tissue Proteins / Q000378:metabolism*; D017475:Receptors, Nerve Growth Factor / Q000378:metabolism*; D055748:SOXB1 Transcription Factors / Q000378:metabolism; D013234:Stem Cells / Q000378:metabolism*
chemical_list: C484065:NGFR protein, human; D009419:Nerve Tissue Proteins; D017475:Receptors, Nerve Growth Factor; C490906:SOX1 protein, human; C527782:SOX2 protein, human; D055748:SOXB1 Transcription Factors
keywords: Dental pulp stem cells; Neural crest stem cells; SOX2; SOX9; p75 Neurotrophin receptor