title: Precision active pharmaceutical ingredients are the goal.
abstract: Understanding and exploiting molecular mechanisms in biology is central to chemical biology. Chemical biology studies of biological macromolecules are now in a perfect continuum with molecular level and nanomolecular level mechanistic studies involving whole organisms. The potential opportunity presented by such studies is the design and creation of genuine precision active pharmaceutical ingredients (APIs; including DNA, siRNA, smaller-molecule bioactives) that demonstrate exceptional levels of disease target specificity and selectivity. This article covers the best of my personal and collaborative academic research work using an organic chemistry and chemical biology approach towards understanding biological molecular recognition processes, work that appears to be leading to the generation of novel precision APIs with genuine potential for the treatments of major chronic diseases that afflict globally.
authors.affiliation: Institute of Pharmaceutical Science, Kings College London, Franklin-Wilkins Building, Waterloo Campus, 150 Stamford Street, London SE1 9NH, UK.|KP Therapeutics Ltd, 86 Deansgate, Manchester, M3 2ER, UK.
authors.forename: Andrew D
authors.initials: AD
authors.lastname: Miller
mesh_terms: D002908:Chronic Disease / Q000188:drug therapy*; D006040:Goals; D006801:Humans; D015394:Molecular Structure; D004364:Pharmaceutical Preparations / Q000737:chemistry*
chemical_list: D004364:Pharmaceutical Preparations
keywords: antisense peptides; chemical biology; chemistry of stress; complementary peptides; diadenosine polyphosphates; dinucleoside polyphosphates; molecular chaperones; precision active pharmaceutical ingredients; precision medicine; synthetic biology; thioether fatty acids