title: A remarkable hematological and molecular response pattern in a patient with polycythemia vera during combination therapy with simvastatin and alendronate.
abstract: We report a 57-year old man with polycythemia vera, who had a remarkable hematological and molecular response during treatment with simvastatin and alendronate. The patient was treated with this combination for 56 months, and during this period the patient has been in complete hematological remission. The JAK2-V617F allele burden has dropped from 64% to sustained values below 20%, and follow-up bone marrow biopsies have revealed no change in PV features, without any regular cytoreductive treatment.
authors.affiliation: Department of Hematology, Zealand University Hospital, Denmark; Institute for Inflammation Research, Center for Rheumatology and Spine Diseases, Rigshospitalet Copenhagen University Hospital, Denmark.
authors.forename: Anders Lindholm
authors.initials: AL
authors.lastname: Sørensen
authors.affiliation: Department of Pathology, Zealand University Hospital, Denmark.
authors.forename: Klaus
authors.initials: K
authors.lastname: Kallenbach
authors.affiliation: Department of Hematology, Zealand University Hospital, Denmark.
authors.forename: Hans Carl
authors.initials: HC
authors.lastname: Hasselbalch
keywords: Alendronate; JAK2-V617F mutation; Myeloproliferative neoplasms; Polycythemia vera; Simvastatin