title: Extensive deep vein thrombosis treatment using fondaparinux and edoxaban: a case report.
abstract: BACKGROUND
  Factor Xa inhibitor is a key drug in the coagulation cascade. Parenteral anticoagulation using low molecular weight heparin or fondaparinux is the recommended form of treatment for most patients presenting with venous thrombosis. Following the acute phase, edoxaban is recommended. We present a case of extensive deep vein thrombosis treated using fondaparinux and edoxaban.
  
  
  METHODS
  A 63-year-old man with redness, pain, and swelling of the left leg lasting for more than 1 month was referred to our hospital. Ultrasonography revealed a thrombus in the left femoral vein. Computed tomographic angiography revealed clots in the distal right pulmonary artery. Thus, the anticoagulant treatment was initiated with subcutaneous injections of fondaparinux (7.5 mg) for 5 consecutive days, followed by once daily oral administration of edoxaban (60 mg). After 3 months of treatment, a regression of thrombotic clots was shown. Three months later, the remaining clots disappeared, leaving only mural thrombi; no bleeding complications were observed during the treatment period.
  
  
  CONCLUSIONS
  The anticoagulant treatment with subcutaneous fondaparinux and subsequently with oral edoxaban was effective for treating extensive deep vein thrombosis.
authors.affiliation: Department of Internal Medicine, Toho University Sakura Medical Center, Chiba, Japan.
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Shimizu
authors.affiliation: Department of Clinical Functional Physiology, Toho University Sakura Medical Center, Chiba, Japan.
authors.forename: Takeshi
authors.initials: T
authors.lastname: Sasaki
authors.affiliation: Department of Clinical Functional Physiology, Toho University Sakura Medical Center, Chiba, Japan.
authors.forename: Takanobu
authors.initials: T
authors.lastname: Tomaru
authors.affiliation: Department of Internal Medicine, Toho University Sakura Medical Center, Chiba, Japan.
authors.forename: Hirofumi
authors.initials: H
authors.lastname: Noike
keywords: Deep vein thrombosis; Edoxaban; Factor Xa inhibitor; Fondaparinux; Venous thromoboembolism