title: Evolutionary Phase Transitions in Random Environments.
abstract: We present analytical results for long-term growth rates of structured populations in randomly fluctuating environments, which we apply to predict how cellular response networks evolve. We show that networks which respond rapidly to a stimulus will evolve phenotypic memory exclusively under random (i.e., nonperiodic) environments. We identify the evolutionary phase diagram for simple response networks, which we show can exhibit both continuous and discontinuous transitions. Our approach enables exact analysis of diverse evolutionary systems, from viral epidemics to emergence of drug resistance.
authors.affiliation: Department of Biology, Center for Genomics and Systems Biology, New York University, New York, New York 10003, USA.
authors.forename: Antun
authors.initials: A
authors.lastname: Skanata
authors.affiliation: Department of Biology, Center for Genomics and Systems Biology, New York University, New York, New York 10003, USA.|Department of Physics, New York University, New York, New York 10003, USA.
authors.forename: Edo
authors.initials: E
authors.lastname: Kussell
mesh_terms: D000220:Adaptation, Biological; D005075:Biological Evolution; D004777:Environment; D008957:Models, Genetic; D010641:Phenotype