title: Current perspective on the role of the interleukin-23/interleukin-17 axis in inflammation and disease (chronic arthritis and psoriasis).
abstract: TH17 is a lymphocyte subset, which is characterized by its polarization to secrete interleukin (IL)-17. IL-23 is the pivotal mediator responsible for TH17 differentiation and the IL-23/IL-17 axis has been strongly implicated in the pathogenesis of several immune mediated diseases, in particular chronic arthritis and skin psoriasis. This review will summarize the basic immunology and the new monoclonal antibodies, which antagonize this pathway allowing a new therapeutic approach.
authors.affiliation: Rheumatology Unit, Department of Medical Sciences, Policlinico of the University of Cagliari, Monserrato, Cagliari, Italy.
authors.forename: Alberto
authors.initials: A
authors.lastname: Cauli
authors.affiliation: Rheumatology Unit, Department of Medical Sciences, Policlinico of the University of Cagliari, Monserrato, Cagliari, Italy.
authors.forename: Matteo
authors.initials: M
authors.lastname: Piga
authors.affiliation: Rheumatology Unit, Department of Medical Sciences, Policlinico of the University of Cagliari, Monserrato, Cagliari, Italy.
authors.forename: Alberto
authors.initials: A
authors.lastname: Floris
authors.affiliation: Rheumatology Unit, Department of Medical Sciences, Policlinico of the University of Cagliari, Monserrato, Cagliari, Italy.
authors.forename: Alessandro
authors.initials: A
authors.lastname: Mathieu
keywords: IL-17; IL-23; TH17; ankylosing spondylitis; psoriasis; psoriatic arthritis