title: Collagen-grafted porous HDPE/PEAA scaffolds for bone reconstruction.
abstract: After tumor resection, bone reconstruction such as skull base reconstruction using interconnected porous structure is absolutely necessary. In this study, porous scaffolds for bone reconstruction were prepared using heat-pressing and salt-leaching methods. High-density polyethylene (HDPE) and poly(ethylene-co-acrylic acid) (PEAA) were chosen as the polymer composites for producing a porous scaffold of high mechanical strength and having high reactivity with biomaterials such as collagen, respectively. The porous structure was observed through surface images, and its intrusion volume and porosity were measured. Owing to the carboxylic acids on PEAA, collagen was successfully grafted onto the porous HDPE/PEAA scaffold, which was confirmed by FT-IR spectroscopy and electron spectroscopy for chemical analysis. Osteoblasts were cultured on the collagen-grafted porous scaffold, and their adhesion, proliferation, and differentiation were investigated. The high viability and growth of the osteoblasts suggest that the collagen-grafted porous HDPE/PEAA is a promising scaffold material for bone generation.
authors.affiliation: Department of Polymer Science and Engineering, Kyungpook National University, Daegu, 702-701 South Korea.
authors.forename: Chang-Shik
authors.initials: CS
authors.lastname: Kim
authors.affiliation: Department of Advanced Materials and Chemical Engineering, Catholic University of Daegu, Kyungsan, South Korea.
authors.forename: Kyung-Hye
authors.initials: KH
authors.lastname: Jung
authors.affiliation: Jeil Medical Corporation, Seoul, South Korea.
authors.forename: Hun
authors.initials: H
authors.lastname: Kim
authors.affiliation: Jeil Medical Corporation, Seoul, South Korea.
authors.forename: Chan-Bong
authors.initials: CB
authors.lastname: Kim
authors.affiliation: Department of Polymer Science and Engineering, Kyungpook National University, Daegu, 702-701 South Korea.
authors.forename: Inn-Kyu
authors.initials: IK
authors.lastname: Kang
keywords: Collagen; Differentiation; High-density polyethylene; Osteoblasts; Porous scaffolds