title: The role of hyperinsulinemia as a cardiometabolic risk factor independent of obesity in polycystic ovary syndrome.
abstract: The aim of this study was to utilize various insulin resistance measuring methods to determine whether insulin resistance and other parameters impact the serum lipid levels of polycystic ovary syndrome (PCOS) patients and how the serum lipid levels in these patients are affected by the body mass index (BMI). Our dataset included patients between the ages of 16 and 42 (N = 228) from the outpatient endocrinology clinic of the Department of Obstetrics and Gynecology, who demonstrated increased hair growth and bleeding disorders and came for a routine oral glucose tolerance test (OGTT). Differences in the serum lipid levels were evaluated by t-test and linear regression analysis after adjusting for BMI. A stepwise regression model was constructed to evaluate the influence of each variable on the lipid levels. In PCOS patients, we found that dyslipidemia is more prevalent among hyperinsulinemic women compared with normoinsulinemic women, even after normalizing for BMI. PCOS patients with insulin resistance, determined by the insulin sensitivity index (ISI) method, showed more significant lipid abnormalities such as low high-density lipoprotein (HDL) and apo-A levels and high total cholesterol, low-density lipoprotein (LDL) and apo-B levels than if insulin resistance (IR) determination was based on insulin level or homeostatic model assessment (HOMA).
authors.affiliation: a Department of Preventive Medicine , Faculty of Public Health.
authors.forename: Orsolya Karola
authors.initials: OK
authors.lastname: Csenteri
authors.affiliation: b Division of Biostatistics and Epidemiology , Department of Preventive Medicine, Faculty of Public Health.
authors.forename: János
authors.initials: J
authors.lastname: Sándor
authors.affiliation: c Department of Laboratory Medicine , Faculty of Medicine, University of Debrecen , Debrecen , Hungary , and.
authors.forename: Edit
authors.initials: E
authors.lastname: Kalina
authors.affiliation: c Department of Laboratory Medicine , Faculty of Medicine, University of Debrecen , Debrecen , Hungary , and.
authors.forename: Harjit Pal
authors.initials: HP
authors.lastname: Bhattoa
authors.affiliation: a Department of Preventive Medicine , Faculty of Public Health.|d Endocrinology Clinic, Department of Obstetrics and Gynecology, University of Debrecen Clinical Center , Debrecen , Hungary.
authors.forename: Sándor
authors.initials: S
authors.lastname: Gődény
mesh_terms: D000328:Adult; D002318:Cardiovascular Diseases / Q000097:blood* / Q000453:epidemiology; D005260:Female; D006801:Humans; D006946:Hyperinsulinism / Q000097:blood* / Q000453:epidemiology; D007333:Insulin Resistance; D009765:Obesity / Q000097:blood* / Q000453:epidemiology; D011085:Polycystic Ovary Syndrome / Q000097:blood* / Q000453:epidemiology; D012307:Risk Factors; D055815:Young Adult
keywords: Cardiovascular risk; insulin resistance; obesity; polycystic ovary syndrome