title: Effect of Ginkgo Biloba Extract on the Pharmacokinetics and Metabolism of Clopidogrel in Rats.
abstract: Ginkgo biloba extract (GBE), a traditional herbal product used worldwide as both medicine and supplement, is often supplied with clopidogrel for the treatment of cerebrovascular diseases. The aim of the current study was to explore the effect of GBE on the metabolism and pharmacokinetics of clopidogrel. The in vitro study using rat liver microsomes revealed that GBE significantly induced the conversion of clopidogrel into its active metabolite. The effect of GBE on the pharmacokinetics of clopidogrel was also investigated in vivo. Compared to rats without GBE pretreatment, administration of 4 mg/kg, 20 mg/kg, and 100 mg/kg of GBE significantly decreased the Cmaxand the AUC0-∞of clopidogrel in a dose-dependent manner. As expected, pretreatment of high dose GBE significantly increased the Cmaxand AUC0-∞of the clopidogrel active metabolite. However, no marked change was observed following medium and low dose of GBE, suggesting that the biotransformation of clopidogrel was altered differently by high dose of GBE. Our study suggested that the awareness of the potential herb-drug interactions between GBE and clopidogrel should be increased in clinical practice. Copyright © 2016 John Wiley & Sons, Ltd.
authors.affiliation: Department of Pharmacy, The People's Hospital of Baoan Shenzhen, Guangdong, 518101, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Deng
authors.affiliation: Department of Pharmacology and Pharmacy, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong.
authors.forename: Yu-Fei
authors.initials: YF
authors.lastname: Mo
authors.affiliation: School of Biomedical Sciences, The Chinese University of Hong Kong, Shatin, N. T., Hong Kong.
authors.forename: Xin-Meng
authors.initials: XM
authors.lastname: Chen
authors.affiliation: Department of Pharmacy, The People's Hospital of Baoan Shenzhen, Guangdong, 518101, China.
authors.forename: Lv-Zhao
authors.initials: LZ
authors.lastname: Zhang
authors.affiliation: Department of Pharmacy, The People's Hospital of Baoan Shenzhen, Guangdong, 518101, China.
authors.forename: Chao-Feng
authors.initials: CF
authors.lastname: Liao
authors.affiliation: Department of Pharmacy, The People's Hospital of Baoan Shenzhen, Guangdong, 518101, China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Song
authors.affiliation: Department of Pharmacy, School of Medicine, Shenzhen University, Shenzhen, Guangdong, 518060, China. cshuxu@szu.edu.cn.
authors.forename: Chenshu
authors.initials: C
authors.lastname: Xu
mesh_terms: D000818:Animals; D000077144:Clopidogrel; D020441:Ginkgo biloba / Q000737:chemistry*; D041743:Herb-Drug Interactions / Q000276:immunology*; D008297:Male; D010936:Plant Extracts / Q000737:chemistry* / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D013988:Ticlopidine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000378:metabolism / Q000493:pharmacokinetics
chemical_list: D010936:Plant Extracts; D000077144:Clopidogrel; D013988:Ticlopidine
keywords: clopidogrel; ginkgo biloba extract; herb-drug interaction; metabolism; pharmacokinetics