title: Autologous bone-marrow mesenchymal cell induced chondrogenesis (MCIC).
abstract: Degenerative and traumatic articular cartilage defects are common, difficult to treat, and progressive lesions that cause significant morbidity in the general population. There have been multiple approaches to treat such lesions, including arthroscopic debridement, microfracture, multiple drilling, osteochondral transplantation and autologous chondrocyte implantation (ACI) that are currently being used in clinical practice. Autologous bone-marrow mesenchymal cell induced chondrogenesis (MCIC) is a single-staged arthroscopic procedure. This method combines a modified microfracture technique with the application of a bone marrow aspirate concentrate (BMAC), hyaluronic acid and fibrin gel to treat articular cartilage defects. We reviewed the current literatures and surgical techniques for mesenchymal cell induced chondrogenesis.
authors.affiliation: Department of Orthopaedic Surgery, College of Medicine, The Catholic University of Korea, Republic of Korea.
authors.forename: Sung Woo
authors.initials: SW
authors.lastname: Huh
authors.affiliation: Canterbury Christ Church University, Faculty of Health and Social Sciences, 30 Pembroke Court, Chatham Maritime, Kent ME4 4UF, United Kingdom.
authors.forename: Asode Ananthram
authors.initials: AA
authors.lastname: Shetty
authors.affiliation: Canterbury Christ Church University, Faculty of Health and Social Sciences, 30 Pembroke Court, Chatham Maritime, Kent ME4 4UF, United Kingdom.
authors.forename: Saif
authors.initials: S
authors.lastname: Ahmed
authors.affiliation: Department of Orthopaedic Surgery, College of Medicine, The Catholic University of Korea, Republic of Korea.
authors.forename: Dong Hwan
authors.initials: DH
authors.lastname: Lee
authors.affiliation: Department of Orthopaedic Surgery, College of Medicine, The Catholic University of Korea, Republic of Korea.
authors.forename: Seok Jung
authors.initials: SJ
authors.lastname: Kim
keywords: Arthrosis; Bone marrow aspirate concentrate; Cartilage; Chondral defect; Knee arthroscopy