title: Effect of Preoperative Nutritional Status on Surgical Site Infection in Colorectal Cancer Resection.
abstract: OBJECTIVE
  Postoperative complications of colorectal cancer (CRC) can sometimes be life threatening. Prevention of morbidity is therefore the most important issue, and among such complications, surgical site infections (SSIs) are the most critical. Predictive factors for SSI were evaluated.
  
  
  METHODS
  This was a retrospective study of 432 patients with CRC. SSIs were classified into incisional SSIs (iSSIs) and organ/space SSIs (o/sSSIs).
  
  
  RESULTS
  Preoperative serum albumin (relative risk (RR) 2.51, p = 0.01) and body mass index (BMI: RR 2.36, p = 0.02) were the independent risk factors for iSSIs, while rectal cancer (RR 6.34, p < 0.0001), preoperative serum albumin (RR 7.03, p = 0.004), age (RR 2.71, p = 0.02), and male sex (RR 2.41, p = 0.05) were the independent risk factors for o/sSSIs. Patients with both low serum albumin and high BMI had the highest incidence of iSSIs (34.2%), and the group with rectal cancer and low serum albumin had the highest incidence of o/sSSIs (57.1%).
  
  
  CONCLUSIONS
  Preoperative nutritional status is a risk factor for SSIs in CRC, and its proper preoperative management may reduce the risk of SSIs.
authors.affiliation: Department of Surgery, Kitasato University School of Medicine, Minami-ku, Sagamihara, Japan.
authors.forename: Toshimichi
authors.initials: T
authors.lastname: Tanaka
authors.forename: Takeo
authors.initials: T
authors.lastname: Sato
authors.forename: Keishi
authors.initials: K
authors.lastname: Yamashita
authors.forename: Kei
authors.initials: K
authors.lastname: Hosoda
authors.forename: Takatoshi
authors.initials: T
authors.lastname: Nakamura
authors.forename: Masahiko
authors.initials: M
authors.lastname: Watanabe
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015992:Body Mass Index; D003110:Colonic Neoplasms / Q000097:blood / Q000601:surgery*; D005260:Female; D006801:Humans; D015994:Incidence; D007902:Length of Stay; D008297:Male; D008875:Middle Aged; D015233:Models, Statistical; D009752:Nutritional Status; D057234:Preoperative Period; D011336:Probability; D012004:Rectal Neoplasms / Q000097:blood / Q000601:surgery*; D012189:Retrospective Studies; D012307:Risk Factors; D012709:Serum Albumin / Q000378:metabolism*; D012737:Sex Factors; D013530:Surgical Wound Infection / Q000453:epidemiology*
chemical_list: D012709:Serum Albumin