title: [Infections of the spine : Therapeutic strategies].
abstract: Spinal infections are relatively rare entities but the incidence is significantly increasing due to the rapidly growing numbers of interventions on the spine. Primary infections of intervertebral discs (spondylodiscitis) and vertebral bodies (spondylitis) are distinguished from secondary postinterventional infections. Treatment relies primarily on either conservative or surgical management. In the absence of indications for surgery, a conservative approach is indicated when the patient is neurologically intact and the bony destruction is minimal. Conservative therapeutic options are based on the microbiological diagnosis and use of antibiotics, immobilization, analgesics and orthotics. Indications for a surgical intervention are the presence of neurological deficits, intraspinal abscesses, extensive osseous destruction and failure of conservative management. Surgical therapy focusses on the decompression of neural structures, debridement and eradication of the focus of infection, pathogen identification, correction of the deformity and restoration of a physiological spinal profile. Following a postoperative infection a timely diagnosis including assessment of the extent of infection is crucial. In the case of a purely superficial infection, antibiotic prophylaxis and close monitoring is indicated. If findings are pronounced surgical revision, debridement together with antibiotic therapy and if necessary vacuum-assisted closure as well as revision ranging from exchange of implants to complete removal of osteosynthetic material are required. Spinal infections are severe conditions frequently with residual long-term sequelae, whether the patients are managed conservatively or surgically.
authors.affiliation: Orthopädische Universitätsklinik Ulm am RKU, Universität Ulm, Oberer Eselsberg 45, 89081, Ulm, Deutschland. Sebastian.Weckbach@rku.de.
authors.forename: S
authors.initials: S
authors.lastname: Weckbach
authors.affiliation: Orthopädische Universitätsklinik Ulm am RKU, Universität Ulm, Oberer Eselsberg 45, 89081, Ulm, Deutschland.
authors.forename: B
authors.initials: B
authors.lastname: Lutz
authors.affiliation: Orthopädische Universitätsklinik Ulm am RKU, Universität Ulm, Oberer Eselsberg 45, 89081, Ulm, Deutschland.
authors.forename: J V
authors.initials: JV
authors.lastname: Wölfle-Roos
authors.affiliation: Orthopädische Universitätsklinik Ulm am RKU, Universität Ulm, Oberer Eselsberg 45, 89081, Ulm, Deutschland.
authors.forename: H
authors.initials: H
authors.lastname: Reichel
mesh_terms: D000465:Algorithms; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D003131:Combined Modality Therapy; D000072700:Conservative Treatment; D003646:Debridement; D019299:Decompression, Surgical; D015299:Discitis / Q000175:diagnosis / Q000628:therapy*; D017586:Diskectomy; D006801:Humans; D054843:Negative-Pressure Wound Therapy; D013123:Spinal Fusion; D013166:Spondylitis / Q000175:diagnosis* / Q000628:therapy*
chemical_list: D000900:Anti-Bacterial Agents
keywords: Antibiotics; Nonsurgical therapy; Operative therapy; Spondylitis; Spondylodiscitis