title: [Chronic Kidney Disease and Bone].
abstract: Both bone and kidney are members of the physiological network sharing a purpose of systemic mineral metabolism. In patients with chronic kidney disease whose kidney function is lost, the organ functions of other mineral metabolism network member including bone fail into uncontrollable due to dysregulated feedback system. This is the concept of Chronic Kidney Disease(related)- Mineral and Bone Disorder(CKD-MBD). However, the bone metabolic abnormalities in patients with chronic kidney disease cannot be explained merely by the framework of this mineral metabolism network. Although dialysis patients show several times higher hip fracture risk than general population, the main pathogenesis seems not to be their disordered mineral metabolism. We need to consider "uremic osteoporosis" characterized by deteriorated bone material properties due to uremic condition.
authors.affiliation: Department of Nephrology and Hypertension, Fukushima Medical University, Japan.
authors.forename: Junichiro
authors.initials: J
authors.lastname: James
mesh_terms: D000818:Animals; D015519:Bone Density; D001842:Bone and Bones / Q000378:metabolism; D012080:Chronic Kidney Disease-Mineral and Bone Disorder / Q000503:physiopathology; D050723:Fractures, Bone / Q000209:etiology; D006801:Humans; D006435:Renal Dialysis