title: Formation of redispersible polyelectrolyte complex nanoparticles from gallic acid-chitosan conjugate and gum arabic.
abstract: Polyelectrolyte complex (PEC) nanoparticles between chitosan (CS) and biomacromolecules offer better physicochemical properties as delivery vehicles for nutrients than other CS-based nanoparticles. Our major objective was to fabricate PEC nanoparticles between water soluble gallic acid-chitosan conjugate (GA-CS) and gum arabic. The optimal fabrication method, physicochemical characteristics and stability were investigated. Furthermore, we also evaluated the effects of nano spray drying technology on the morphology and redispersibility of nanoparticle powders using Buchi B-90 Nano Spray Dryer. Results showed that the mass ratio between GA-CS and gum arabic and the preparation pH had significant contributions in determining the particle size and count rate of the nanoparticles, with the ratio of 3:1 and pH 5.0 being the optimal conditions that resulted in 112.2nm and 122.9kcps. The polyethylene glycol (PEG) played a vital role in forming the well-separated spray dried nanoparticles. The most homogeneous nanoparticles with the smoothest surface were obtained when the mass ratio of GA-CS and PEG was 1:0.5. In addition, the GA-CS/gum arabic spray dried nanoparticles exhibited excellent water-redispersibiliy compared to native CS/gum arabic nanoparticles. Our results demonstrated GA-CS/gum arabic nanoparticles were successfully fabricated with promising physicochemical properties and great potential for their applications in food and pharmaceutical industries.
authors.affiliation: Department of Nutritional Sciences, University of Connecticut, Storrs, CT 06269, USA.
authors.forename: Qiaobin
authors.initials: Q
authors.lastname: Hu
authors.affiliation: Department of Nutritional Sciences, University of Connecticut, Storrs, CT 06269, USA.
authors.forename: Taoran
authors.initials: T
authors.lastname: Wang
authors.affiliation: Department of Nutritional Sciences, University of Connecticut, Storrs, CT 06269, USA.
authors.forename: Mingyong
authors.initials: M
authors.lastname: Zhou
authors.affiliation: Department of Nutritional Sciences, University of Connecticut, Storrs, CT 06269, USA.
authors.forename: Jingyi
authors.initials: J
authors.lastname: Xue
authors.affiliation: Department of Nutritional Sciences, University of Connecticut, Storrs, CT 06269, USA. Electronic address: yangchao.luo@uconn.edu.
authors.forename: Yangchao
authors.initials: Y
authors.lastname: Luo
mesh_terms: D048271:Chitosan / Q000737:chemistry*; D003890:Desiccation; D016503:Drug Delivery Systems; D006170:Gum Arabic / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D053758:Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D010316:Particle Size; D000071228:Polyelectrolytes / Q000737:chemistry*; D011092:Polyethylene Glycols / Q000737:chemistry; D011208:Powders; D013499:Surface Properties
chemical_list: D000071228:Polyelectrolytes; D011208:Powders; D011092:Polyethylene Glycols; D006170:Gum Arabic; D048271:Chitosan
keywords: Gallic acid-chitosan conjugate; Gum arabic; Nano spray drying; Nanoparticles; Polyelectrolyte complex; Redispersibility