title: Platelet gel: a new therapeutic tool with great potential.
abstract: Chronic wounds, such as diabetic foot ulcers, represent a serious clinical problem for patients and clinicians. Management of these wounds has a strong economic impact worldwide. Complications resulting from injuries are a frequent cause of morbidity and mortality. Chronic wounds lead to infections, painful dressings and prolonged hospitalisation. This results in poor patient Quality of Life and in high healthcare costs. Platelet concentrates (PC) are defined as autologous or allogeneic platelet derivatives with a platelet concentration higher than baseline. PC are widely used in different areas of Regenerative Medicine in order to enhance wound healing processes; they include platelet-rich plasma (PRP), platelet gel (PG), platelet-rich fibrin (PRF), serum eye drops (E-S), and PRP eye drops (E-PRP). This review highlights the use of platelet-rich plasma (PRP) and platelet gel (PG) preparation for clinical use.
authors.affiliation: Haematology Department, San Maurizio Regional Hospital, Bolzano, Austria.|Regenerative Medicine Group, San Maurizio Regional Hospital, Bolzano, Italy.|IMREST, San Maurizio Regional Hospital, Bolzano, Austria.
authors.forename: Andrea
authors.initials: A
authors.lastname: Piccin
authors.affiliation: Haematology Department, San Maurizio Regional Hospital, Bolzano, Austria.|Regenerative Medicine Group, San Maurizio Regional Hospital, Bolzano, Italy.|IMREST, San Maurizio Regional Hospital, Bolzano, Austria.|Biochemistry Laboratory, San Maurizio Regional Hospital, Bolzano, Austria.|Department of Internal Medicine V, Innsbruck Medical University, Innsbruck, Austria.
authors.forename: Angela M
authors.initials: AM
authors.lastname: Di Pierro
authors.affiliation: Blood Transfusion Service, San Maurizio Regional Hospital, Bolzano, Austria.
authors.forename: Lucia
authors.initials: L
authors.lastname: Canzian
authors.affiliation: Regenerative Medicine Group, San Maurizio Regional Hospital, Bolzano, Italy.|IMREST, San Maurizio Regional Hospital, Bolzano, Austria.|Pharmacology Service, San Maurizio Regional Hospital, Bolzano, Austria.
authors.forename: Marco
authors.initials: M
authors.lastname: Primerano
authors.affiliation: Haematology Department, San Maurizio Regional Hospital, Bolzano, Austria.|Regenerative Medicine Group, San Maurizio Regional Hospital, Bolzano, Italy.|IMREST, San Maurizio Regional Hospital, Bolzano, Austria.|Pathology Department, San Maurizio Regional Hospital, Bolzano, Austria.
authors.forename: Daisy
authors.initials: D
authors.lastname: Corvetta
authors.affiliation: Regenerative Medicine Group, San Maurizio Regional Hospital, Bolzano, Italy.|IMREST, San Maurizio Regional Hospital, Bolzano, Austria.|Pathology Department, San Maurizio Regional Hospital, Bolzano, Austria.
authors.forename: Giovanni
authors.initials: G
authors.lastname: Negri
authors.affiliation: Regenerative Medicine Group, San Maurizio Regional Hospital, Bolzano, Italy.|IMREST, San Maurizio Regional Hospital, Bolzano, Austria.|Pathology Department, San Maurizio Regional Hospital, Bolzano, Austria.
authors.forename: Guido
authors.initials: G
authors.lastname: Mazzoleni
authors.affiliation: Department of Internal Medicine V, Innsbruck Medical University, Innsbruck, Austria.
authors.forename: Günther
authors.initials: G
authors.lastname: Gastl
authors.affiliation: Department of Internal Medicine V, Innsbruck Medical University, Innsbruck, Austria.
authors.forename: Michael
authors.initials: M
authors.lastname: Steurer
authors.affiliation: Blood Transfusion Service, San Maurizio Regional Hospital, Bolzano, Austria.
authors.forename: Ivo
authors.initials: I
authors.lastname: Gentilini
authors.affiliation: Regenerative Medicine Group, San Maurizio Regional Hospital, Bolzano, Italy.|IMREST, San Maurizio Regional Hospital, Bolzano, Austria.|Dermatology Department, San Maurizio Regional Hospital, Bolzano, Italy.
authors.forename: Klaus
authors.initials: K
authors.lastname: Eisendle
authors.affiliation: Regenerative Medicine Group, San Maurizio Regional Hospital, Bolzano, Italy.|IMREST, San Maurizio Regional Hospital, Bolzano, Austria.|Odontostomathology Unit, San Maurizio Regional Hospital, Bolzano, Italy.
authors.forename: Fabrizio
authors.initials: F
authors.lastname: Fontanella
mesh_terms: D001792:Blood Platelets; D017719:Diabetic Foot / Q000188:drug therapy*; D005782:Gels; D006801:Humans; D000073183:Platelet-Rich Fibrin
chemical_list: D005782:Gels