title: Oxidized LDL at the crossroads of immunity in non-alcoholic steatohepatitis.
abstract: Non-alcoholic steatohepatitis (NASH) is viewed as the hepatic manifestation of the metabolic syndrome and is a condition hallmarked by lipid accumulation in the liver (steatosis) along with inflammation (hepatitis). Currently, the etiology and mechanisms leading to obesity-induced hepatic inflammation are not clear and, as a consequence, strategies to diagnose or treat NASH in an accurate manner do not exist. In the current review, we put forward the concept of oxidized lipids as a significant risk factor for NASH. We will focus on the contribution of the different types of oxidized lipids as part of the oxidized low-density lipoprotein (oxLDL) to the hepatic inflammatory response. Furthermore, we will elaborate on the underlying mechanisms linking oxLDL to inflammatory responses in the liver and on how these cascades can be used as therapeutic targets to combat NASH. This article is part of a Special Issue entitled: Lipid modification and lipid peroxidation products in innate immunity and inflammation edited by Christoph J. Binder.
authors.affiliation: Department of Molecular Genetics, Maastricht University, School for Nutrition and Translational Research in Metabolism (NUTRIM), Maastricht, the Netherlands.
authors.forename: T
authors.initials: T
authors.lastname: Houben
authors.affiliation: Molecular Genetics Section, Department of Pediatrics, University Medical Center Groningen, University of Groningen, the Netherlands.
authors.forename: E
authors.initials: E
authors.lastname: Brandsma
authors.affiliation: Department of Molecular Genetics, Maastricht University, School for Nutrition and Translational Research in Metabolism (NUTRIM), Maastricht, the Netherlands.
authors.forename: S M A
authors.initials: SMA
authors.lastname: Walenbergh
authors.affiliation: Molecular Genetics Section, Department of Pediatrics, University Medical Center Groningen, University of Groningen, the Netherlands.
authors.forename: M H
authors.initials: MH
authors.lastname: Hofker
authors.affiliation: Department of Molecular Genetics, Maastricht University, School for Nutrition and Translational Research in Metabolism (NUTRIM), Maastricht, the Netherlands. Electronic address: r.sverdlov@maastrichtuniversity.nl.
authors.forename: R
authors.initials: R
authors.lastname: Shiri-Sverdlov
mesh_terms: D006801:Humans; D007249:Inflammation / Q000276:immunology / Q000378:metabolism; D050356:Lipid Metabolism / Q000276:immunology / Q000502:physiology; D008077:Lipoproteins, LDL / Q000276:immunology* / Q000378:metabolism*; D008099:Liver / Q000276:immunology / Q000378:metabolism; D065626:Non-alcoholic Fatty Liver Disease / Q000276:immunology* / Q000378:metabolism*
chemical_list: D008077:Lipoproteins, LDL; C099252:oxidized low density lipoprotein
keywords: Hepatic inflammation; Lipid metabolism; NASH; OxLDL