title: Synchronous Quadruple Primary Neoplasms: Colon Adenocarcinoma, Collision Tumor of Neuroendocrine Tumor and Schwann Cell Hamartoma and Sessile Serrated Adenoma of the Appendix.
abstract: Quadruple synchronous primary neoplasms are very rare with only three cases reported in the English-speaking literature to date. Collision tumors are also rare entities, especially of the appendix. We herein report a case of synchronous quadruple primary neoplasm in a 95-year-old female. She was diagnosed with colon adenocarcinoma, sessile serrated adenoma of the appendix and a collision tumor composed of a well-differentiated neuroendocrine tumor and Schwann cell hamartoma. Histological examination and immunohistochemistry supported these four lesions as separate entities. This case is unique because we report the diagnosis of quadruple synchronous primary, an extremely rare occurrence, in addition to a collision tumor of the appendix. We also provide a review of the literature for synchronous neoplasms and collision tumors.
authors.affiliation: Department of Pathology, Saint Louis University School of Medicine, Saint Louis, MO, U.S.A.
authors.forename: Marshall W
authors.initials: MW
authors.lastname: Meeks
authors.affiliation: Department of Pathology, Saint Louis University School of Medicine, Saint Louis, MO, U.S.A.
authors.forename: Shane
authors.initials: S
authors.lastname: Grace
authors.affiliation: Department of Pathology, Saint Louis University School of Medicine, Saint Louis, MO, U.S.A.
authors.forename: Yongxin
authors.initials: Y
authors.lastname: Chen
authors.affiliation: Department of Pathology, Saint Louis University School of Medicine, Saint Louis, MO, U.S.A.
authors.forename: James
authors.initials: J
authors.lastname: Petterchak
authors.affiliation: Department of Pathology, Saint Louis University School of Medicine, Saint Louis, MO, U.S.A.
authors.forename: Edward
authors.initials: E
authors.lastname: Bolesta
authors.affiliation: Department of Radiology, Saint Louis University School of Medicine, Saint Louis, MO, U.S.A.
authors.forename: Yihua
authors.initials: Y
authors.lastname: Zhou
authors.affiliation: Department of Pathology, Saint Louis University School of Medicine, Saint Louis, MO, U.S.A. jinpinglai@slu.edu.
authors.forename: Jin-Ping
authors.initials: JP
authors.lastname: Lai
mesh_terms: D000230:Adenocarcinoma / Q000175:diagnosis / Q000473:pathology*; D000236:Adenoma / Q000175:diagnosis / Q000473:pathology; D000369:Aged, 80 and over; D001063:Appendiceal Neoplasms / Q000175:diagnosis / Q000473:pathology*; D003110:Colonic Neoplasms / Q000175:diagnosis / Q000473:pathology*; D005260:Female; D006222:Hamartoma / Q000175:diagnosis / Q000473:pathology; D006801:Humans; D009378:Neoplasms, Multiple Primary / Q000175:diagnosis / Q000473:pathology*; D018358:Neuroendocrine Tumors / Q000175:diagnosis / Q000473:pathology; D012583:Schwann Cells / Q000473:pathology
keywords: Synchronous; collision tumor; colon adenocarcinoma; multiple primary malignant neoplasms; neuroendocrine tumor; schwannoma; sessile serrated adenoma/polyp