title: Host-Bacterial Crosstalk Determines Staphylococcus aureus Nasal Colonization.
abstract: Staphylococcus aureus persistently colonizes the anterior nares of approximately one fifth of the population and nasal carriage is a significant risk factor for infection. Recent advances have significantly refined our understanding of S. aureus-host communication during nasal colonization. Novel bacterial adherence mechanisms in the nasal epithelium have been identified, and novel roles for both the innate and the adaptive immune response in controlling S. aureus nasal colonization have been defined, through the use of both human and rodent models. It is clear that S. aureus maintains a unique, complex relationship with the host immune system and that S. aureus nasal colonization is overall a multifactorial process which is as yet incompletely understood.
authors.affiliation: Host-Pathogen Interactions Group, School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland.
authors.forename: Michelle E
authors.initials: ME
authors.lastname: Mulcahy
authors.affiliation: Host-Pathogen Interactions Group, School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland. Electronic address: rachel.mcloughlin@tcd.ie.
authors.forename: Rachel M
authors.initials: RM
authors.lastname: McLoughlin
mesh_terms: D056704:Adaptive Immunity; D000818:Animals; D001422:Bacterial Adhesion; D002353:Carrier State / Q000175:diagnosis / Q000276:immunology / Q000382:microbiology; D004195:Disease Models, Animal; D004847:Epithelial Cells / Q000382:microbiology; D054884:Host-Pathogen Interactions / Q000276:immunology* / Q000502:physiology; D006801:Humans; D007113:Immunity, Innate; D056265:Microbial Interactions / Q000276:immunology; D064307:Microbiota; D009296:Nasal Cavity / Q000276:immunology / Q000382:microbiology*; D009297:Nasal Mucosa / Q000276:immunology / Q000382:microbiology; D009666:Nose / Q000276:immunology / Q000382:microbiology; D012307:Risk Factors; D012377:Rodentia; D013203:Staphylococcal Infections / Q000276:immunology / Q000382:microbiology* / Q000635:transmission; D013211:Staphylococcus aureus / Q000254:growth & development* / Q000276:immunology* / Q000472:pathogenicity / Q000502:physiology
keywords: Staphylococcus aureus; nasal colonization