title: pH responsive polyurethane (core) and cellulose acetate phthalate (shell) electrospun fibers for intravaginal drug delivery.
abstract: In this study we present the use of co-axial electrospinning to produce core-shell composite micro-/nano- fibers of polyurethane (PU) and cellulose acetate phthalate (CAP). The designed fibers possess enhanced mechanical properties with a tensile strength of 13.27±2.32MPa, which is a clear improvement over the existing CAP fibers that suffer from a poor mechanical strength (0.2±0.03MPa). The CAP imparts pH responsiveness to the core-shell structure giving the fibers potential for "semen sensitive" (intravaginal) drug delivery.
authors.affiliation: College of Chemical Engineering, Jiangsu Key Lab of Biomass-based Green Fuels and Chemicals, Nanjing Forestry University (NFU), Nanjing 210037 PR China.
authors.forename: Dawei
authors.initials: D
authors.lastname: Hua
authors.affiliation: College of Chemical Engineering, Jiangsu Key Lab of Biomass-based Green Fuels and Chemicals, Nanjing Forestry University (NFU), Nanjing 210037 PR China.
authors.forename: Zhongche
authors.initials: Z
authors.lastname: Liu
authors.affiliation: College of Chemical Engineering, Jiangsu Key Lab of Biomass-based Green Fuels and Chemicals, Nanjing Forestry University (NFU), Nanjing 210037 PR China.
authors.forename: Fang
authors.initials: F
authors.lastname: Wang
authors.affiliation: Advanced Analysis & Testing Center, Nanjing Forestry University, Nanjing 210037, PR China.
authors.forename: Buhong
authors.initials: B
authors.lastname: Gao
authors.affiliation: Department of Chemical Engineering, Queen's University, Kingston, Ontario K7 L 3N6, Canada.
authors.forename: Fei
authors.initials: F
authors.lastname: Chen
authors.affiliation: Laboratory of Polymer Chemistry, Department of Chemistry, P.O. Box 55, 00014 University of Helsinki, Finland.
authors.forename: Qilu
authors.initials: Q
authors.lastname: Zhang
authors.affiliation: Lab General Biochemistry & Physical Pharmacy, Department of Pharmaceutics, Ghent University, Belgium.
authors.forename: Ranhua
authors.initials: R
authors.lastname: Xiong
authors.affiliation: College of Materials Science and Engineering, Nanjing Forestry University (NFU), Nanjing 210037 PR China.
authors.forename: Jingquan
authors.initials: J
authors.lastname: Han
authors.affiliation: Lab General Biochemistry & Physical Pharmacy, Department of Pharmaceutics, Ghent University, Belgium. Electronic address: SangramKeshari.Samal@UGent.be.
authors.forename: Sangram Keshari
authors.initials: SK
authors.lastname: Samal
authors.affiliation: Lab General Biochemistry & Physical Pharmacy, Department of Pharmaceutics, Ghent University, Belgium. Electronic address: Stefaan.Desmedt@UGent.be.
authors.forename: Stefaan C
authors.initials: SC
authors.lastname: De Smedt
authors.affiliation: College of Chemical Engineering, Jiangsu Key Lab of Biomass-based Green Fuels and Chemicals, Nanjing Forestry University (NFU), Nanjing 210037 PR China. Electronic address: huangchaobo@njfu.edu.cn.
authors.forename: Chaobo
authors.initials: C
authors.lastname: Huang
mesh_terms: D000818:Animals; D002460:Cell Line; D002482:Cellulose / Q000031:analogs & derivatives* / Q000737:chemistry; D004337:Drug Carriers / Q000737:chemistry* / Q000633:toxicity; D065546:Drug Liberation; D004560:Electricity; D005260:Female; D006863:Hydrogen-Ion Concentration; D055595:Mechanical Phenomena; D051379:Mice; D011140:Polyurethanes / Q000737:chemistry*; D012235:Rhodamines / Q000737:chemistry; D014621:Vagina / Q000378:metabolism*
chemical_list: D004337:Drug Carriers; D011140:Polyurethanes; D012235:Rhodamines; D002482:Cellulose; C011708:cellulose acetate phthalate
keywords: Cellulose acetate phthalate; Core-shell electrospinning; Intravaginal drug delivery; Polyurethane