title: Impact of Immune-Modulatory Drugs on Regulatory T Cell.
abstract: Immunosuppression strategies that selectively inhibit effector T cells while preserving and even enhancing CD4FOXP3 regulatory T cells (Treg) permit immune self-regulation and may allow minimization of immunosuppression and associated toxicities. Many immunosuppressive drugs were developed before the identity and function of Treg were appreciated. A good understanding of the interactions between Treg and immunosuppressive agents will be valuable to the effective design of more tolerable immunosuppression regimens. This review will discuss preclinical and clinical evidence regarding the influence of current and emerging immunosuppressive drugs on Treg homeostasis, stability, and function as a guideline for the selection and development of Treg-friendly immunosuppressive regimens.
authors.affiliation: Department of Surgery, University of California, San Francisco, San Francisco, CA, United States.
authors.forename: Akiko
authors.initials: A
authors.lastname: Furukawa
authors.affiliation: Department of Surgery, University of California, San Francisco, San Francisco, CA, United States.
authors.forename: Steven A
authors.initials: SA
authors.lastname: Wisel
authors.affiliation: Department of Surgery, University of California, San Francisco, San Francisco, CA, United States.
authors.forename: Qizhi
authors.initials: Q
authors.lastname: Tang
mesh_terms: D000818:Animals; D015703:Antigens, CD / Q000276:immunology; D000951:Antigens, Neoplasm / Q000276:immunology; D000074301:CD52 Antigen; D065095:Calcineurin Inhibitors / Q000494:pharmacology; D006023:Glycoproteins / Q000276:immunology; D006706:Homeostasis; D006801:Humans; D007166:Immunosuppressive Agents / Q000494:pharmacology*; D007376:Interleukin-2 / Q000494:pharmacology; D053645:Interleukin-2 Receptor alpha Subunit / Q000276:immunology; D019947:Receptors, Interleukin-6 / Q000276:immunology; D050378:T-Lymphocytes, Regulatory / Q000187:drug effects* / Q000276:immunology; D058570:TOR Serine-Threonine Kinases / Q000037:antagonists & inhibitors; D014807:Vitamin D / Q000378:metabolism
chemical_list: D015703:Antigens, CD; D000951:Antigens, Neoplasm; D000074301:CD52 Antigen; C000613862:CD52 protein, human; D065095:Calcineurin Inhibitors; D006023:Glycoproteins; D007166:Immunosuppressive Agents; D007376:Interleukin-2; D053645:Interleukin-2 Receptor alpha Subunit; D019947:Receptors, Interleukin-6; D014807:Vitamin D; D058570:TOR Serine-Threonine Kinases