title: The Infant Aphakia Treatment Study Contact Lens Experience to Age 5 Years.
abstract: OBJECTIVE
  To describe our experience treating a cohort of unilateral aphakic infants with contact lenses in the Infant Aphakia Treatment Study (IATS).
  
  
  METHODS
  Fifty-seven of the 114 infants in the IATS were randomized to contact lens wear; all were followed until age 5 years, although a few had lapses in care. An examination under anesthesia, including keratometry, was performed at the time of enrollment and at approximately 1 year of age; keratometry was performed again at 5 years of age. A traveling examiner assessed visual acuity at approximately 1 year of age and again at 4.5 years of age.
  
  
  RESULTS
  Twenty-four treated eyes (46%) wore silicone elastomer (SE) contact lenses, 11 eyes (19%) rigid gas permeable (GP) contact lenses and 17 eyes (29%) wore both lens types at various points of time. Median logMAR visual acuity was +0.70 (interquartile range (IQR), +0.30 to 1.20) in the SE group and 2.03 (IQR, +0.20 to 2.28) in the GP group at age 4.5 years. The mean (±SD) keratometric power of the treated eyes was 46.3±2.8 diopter (D) at baseline, 44.6±2.3 D at 1 year of age, and 44.3±1.7 D at 5 years of age. Keratometric astigmatism of treated eyes was 1.98±1.37 D at baseline, 1.62±0.98 D at 1 year of age, and 2.00±1.00 D at 5 years of age. Thirteen contact lens-related adverse events occurred among 7 patients after age 1 year.
  
  
  CONCLUSIONS
  A cohort of infants with unilateral aphakia successfully wore contact lenses with relatively few adverse events.
authors.affiliation: Department of Ophthalmology (B.R., L.D., M.A.W., S.R.L.), Emory University School of Medicine, Atlanta, GA; and Department of Biostatistics and Bioinformatics (M.L.), Rollins School of Public Health of Emory University, Atlanta, GA.
authors.forename: Buddy
authors.initials: B
authors.lastname: Russell
authors.forename: Lindreth
authors.initials: L
authors.lastname: DuBois
authors.forename: Michael
authors.initials: M
authors.lastname: Lynn
authors.forename: Michael A
authors.initials: MA
authors.lastname: Ward
authors.forename: Scott R
authors.initials: SR
authors.lastname: Lambert
mesh_terms: D001036:Aphakia, Postcataract / Q000503:physiopathology / Q000628:therapy*; D001251:Astigmatism / Q000503:physiopathology; D002675:Child, Preschool; D003261:Contact Lenses; D003263:Contact Lenses, Hydrophilic; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D014792:Visual Acuity / Q000502:physiology