title: Tongluo Xingnao Effervescent Tablet preserves mitochondrial energy metabolism and attenuates cognition deficits in APPswe/PS1De9 mice.
abstract: Tongluo Xingnao Effervescent Tablet (TXET), a traditional Chinese herbal formula composed of Ligusticum chuanxiong hor, Scutellaria baicalensis Georgi and Angelica sinensis, has been widely used to treat Alzheimer's disease (AD) and related dementias for decades in China. In the present study, we investigated the effects of TXET on mitochondrial function, energy metabolism and cognitive amelioration in the APPswe/PS1De9 transgenetic mouse model of AD. The energy charge and phosphocreatine, activity of the mitochondrial electron transport chain complexes, mitochondrial membrane potential, activity of Na(+)-K(+) ATPase and the expression levels of Bcl-2 and Bax in the brains were measured, respectively. TXET exhibits significant protection on mitochondrial function and energy supply in addition to ameliorating cognitive decline in APPswe/PS1De9 mice. TXET rescues mitochondrial function by increasing the mitochondrial membrane potential, energy charge levels, activity of respiratory chain complexes and Na(+)-K(+) ATPase activity. These findings suggest that TXET may attenuate cognition impairment through the restoration of mitochondrial function and energy metabolism in the brains in APPswe/PS1De9 mice.
authors.affiliation: Chengdu University of Traditional Chinese Medicine, Chengdu 610075, China. Electronic address: daniya5@sina.com.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Dai
authors.affiliation: Dongfang Hospital, Beijing Universtiy of Chinese Medicine, Beijing 100078,China. Electronic address: matao327@126.com.
authors.forename: Tao
authors.initials: T
authors.lastname: Ma
authors.affiliation: Chengdu University of Traditional Chinese Medicine, Chengdu 610075, China. Electronic address: amideby@sina.cn.
authors.forename: Xiangyi
authors.initials: X
authors.lastname: Ren
authors.affiliation: Chengdu University of Traditional Chinese Medicine, Chengdu 610075, China. Electronic address: sichuanwjp@163.com.
authors.forename: Jiangping
authors.initials: J
authors.lastname: Wei
authors.affiliation: Chengdu University of Traditional Chinese Medicine, Chengdu 610075, China. Electronic address: fwj10330@163.com.
authors.forename: Wenjun
authors.initials: W
authors.lastname: Fu
authors.affiliation: Chengdu University of Traditional Chinese Medicine, Chengdu 610075, China. Electronic address: mayuntong06@163.com.
authors.forename: Yuntong
authors.initials: Y
authors.lastname: Ma
authors.affiliation: Chengdu University of Traditional Chinese Medicine, Chengdu 610075, China. Electronic address: docxu@126.com.
authors.forename: Shijun
authors.initials: S
authors.lastname: Xu
authors.affiliation: State Key Laboratory of Cognitive Neuroscience and Learning and IDG/Mc Govern Institute for Brain Research, Beijing Normal University, Beijing 100875, China; BABRI Centre, Beijing Normal University, Beijing, 100875, China. Electronic address: zhang_rzs@bnu.edu.cn.
authors.forename: Zhanjun
authors.initials: Z
authors.lastname: Zhang
mesh_terms: D000544:Alzheimer Disease / Q000150:complications / Q000378:metabolism* / Q000517:prevention & control; D016564:Amyloid beta-Protein Precursor / Q000235:genetics; D000818:Animals; D017209:Apoptosis / Q000187:drug effects; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D003072:Cognition Disorders / Q000150:complications / Q000378:metabolism* / Q000523:psychology; D004195:Disease Models, Animal; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage*; D004579:Electron Transport / Q000187:drug effects; D004734:Energy Metabolism / Q000187:drug effects*; D006801:Humans; D008297:Male; D053078:Membrane Potential, Mitochondrial / Q000187:drug effects; D051379:Mice; D008810:Mice, Inbred C57BL; D008822:Mice, Transgenic; D008928:Mitochondria / Q000187:drug effects* / Q000378:metabolism*; D053764:Presenilin-1 / Q000235:genetics; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000378:metabolism; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism; D065852:Spatial Memory / Q000187:drug effects; D013607:Tablets / Q000008:administration & dosage; D051028:bcl-2-Associated X Protein / Q000378:metabolism
chemical_list: D016564:Amyloid beta-Protein Precursor; C494827:Bax protein, mouse; D004365:Drugs, Chinese Herbal; C508853:PSEN1 protein, human; D053764:Presenilin-1; D019253:Proto-Oncogene Proteins c-bcl-2; D013607:Tablets; D051028:bcl-2-Associated X Protein; C052617:Bcl2 protein, mouse; D000254:Sodium-Potassium-Exchanging ATPase
keywords: Alzheimer’s disease; Energy metabolism; Mitochondria; Tongluo Xingnao Effervescent Tablet