title: Onset of Tuberculosis from a Pulmonary Latent Tuberculosis Infection during Antiviral Triple Therapy for Chronic Hepatitis C.
abstract: A 62-year-old man was diagnosed with the onset of tuberculosis (Tb) from a pulmonary latent tuberculosis infection (LTBI) during triple therapy with pegylated interferon α2a, ribavirin, and telaprevir for a chronic hepatitis C infection in 2013 before interferon (IFN)-free anti-viral therapy was introduced in Japan. A liver biopsy before IFN treatment revealed the presence of epithelioid cell granulomas (ECGs). IFN may also be employed for chronic hepatitis B infection and malignant tumors, thus, special attention must be paid to the development of Tb from a LTBI when ECGs are observed before treatment. It is also necessary to review the significance of the liver biopsy.
authors.affiliation: Division of Gastroenterology and Hepatology, Department of Medicine, Nihon University School of Medicine, Japan.
authors.forename: Shunichi
authors.initials: S
authors.lastname: Matsuoka
authors.forename: Hirotoshi
authors.initials: H
authors.lastname: Fujikawa
authors.forename: Hiromasa
authors.initials: H
authors.lastname: Hasegawa
authors.forename: Takanaga
authors.initials: T
authors.lastname: Ochiai
authors.forename: Yukinobu
authors.initials: Y
authors.lastname: Watanabe
authors.forename: Mitsuhiko
authors.initials: M
authors.lastname: Moriyama
mesh_terms: D000998:Antiviral Agents / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D019698:Hepatitis C, Chronic / Q000188:drug therapy; D006801:Humans; D016898:Interferon-alpha / Q000627:therapeutic use; D055985:Latent Tuberculosis / Q000188:drug therapy* / Q000473:pathology*; D008297:Male; D009842:Oligopeptides / Q000627:therapeutic use; D011092:Polyethylene Glycols / Q000008:administration & dosage; D012254:Ribavirin / Q000627:therapeutic use; D016896:Treatment Outcome
chemical_list: D000998:Antiviral Agents; D016898:Interferon-alpha; D009842:Oligopeptides; D011092:Polyethylene Glycols; D012254:Ribavirin