title: Investigation of cobalt(iii)-triazole systems as prototypes for hypoxia-activated drug delivery.
abstract: Three novel cobalt(iii)-triazole complexes with structural and redox properties suitable for hypoxia-activated drug delivery were obtained. A major influence of the ancillary ligands (TPA, py2en, py2enMe2) on the electronic properties and reactivity of their complexes was observed. An [O2]-dependent reduction to cobalt(ii) by ascorbic acid provided evidence of hypoxic selectivity.
authors.affiliation: Universidade Federal Fluminense, Instituto de Química, Outeiro S. João Batista S/N, 24020-141, Niterói, RJ, Brazil. ml@id.uff.br.
authors.forename: Isabela Cristina Aguiar
authors.initials: IC
authors.lastname: de Souza
authors.forename: Leticia Villafranca
authors.initials: LV
authors.lastname: Faro
authors.forename: Carlos Basilio
authors.initials: CB
authors.lastname: Pinheiro
authors.forename: Daniel Tadeu Gomes
authors.initials: DT
authors.lastname: Gonzaga
authors.forename: Fernando de Carvalho
authors.initials: Fde C
authors.lastname: da Silva
authors.forename: Vitor Francisco
authors.initials: VF
authors.lastname: Ferreira
authors.forename: Fabio da Silva
authors.initials: Fda S
authors.lastname: Miranda
authors.forename: Marciela
authors.initials: M
authors.lastname: Scarpellini
authors.forename: Mauricio
authors.initials: M
authors.lastname: Lanznaster
mesh_terms: D001205:Ascorbic Acid / Q000737:chemistry; D003035:Cobalt / Q000737:chemistry*; D056831:Coordination Complexes / Q000138:chemical synthesis / Q000737:chemistry*; D016503:Drug Delivery Systems / Q000379:methods*; D000860:Hypoxia; D008024:Ligands; D008954:Models, Biological; D015394:Molecular Structure; D010084:Oxidation-Reduction; D010100:Oxygen / Q000737:chemistry*; D011355:Prodrugs / Q000737:chemistry; D014230:Triazoles / Q000138:chemical synthesis / Q000737:chemistry*
chemical_list: D056831:Coordination Complexes; D008024:Ligands; D011355:Prodrugs; D014230:Triazoles; D003035:Cobalt; D001205:Ascorbic Acid; D010100:Oxygen