title: Convergent Synthesis of Dronedarone, an Antiarrhythmic Agent.
abstract: We have developed a convergent synthesis of dronedarone, an antiarrhythmic agent. The key steps of the process are the construction of a benzofuran skeleton by iodocyclization and the carbonylative Suzuki-Miyaura cross-coupling for biaryl ketone formation. This synthetic route required only eight steps from 2-amino-4-nitrophenol in 23% overall yield.
authors.affiliation: Department of Organic Chemistry for Life Science, Kobe Pharmaceutical University.
authors.forename: Takashi
authors.initials: T
authors.lastname: Okitsu
authors.forename: Mizuki
authors.initials: M
authors.lastname: Ogasahara
authors.forename: Akimori
authors.initials: A
authors.lastname: Wada
mesh_terms: D000638:Amiodarone / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry; D000889:Anti-Arrhythmia Agents / Q000138:chemical synthesis* / Q000737:chemistry; D000077764:Dronedarone; D015394:Molecular Structure
chemical_list: D000889:Anti-Arrhythmia Agents; D000077764:Dronedarone; D000638:Amiodarone