title: Neonatal Lupus: What We Have Learned and Current Approaches to Care.
abstract: Neonatal lupus results from the passive transfer of autoantibodies; however, this transfer is not sufficient to cause disease. This article reviews clinical presentation with a focus on autoimmune-mediated congenital heart disease. Recent data looking for additional disease mechanisms and biomarkers as well as latest information on interventions will be reviewed. Our understanding of this rare disease is often dependent on patient participation in disease registries and biorepositories. Future participation in registries including descriptive as well as biophysical data is critical to our knowledge.
authors.affiliation: Division of Rheumatology, Ann & Robert H. Lurie Children's Hospital of Chicago, Northwestern University Feinberg School of Medicine, 225 E. Chicago Avenue, # 50, Chicago, IL, 60611, USA. klein-gitelman@northwestern.edu.
authors.forename: Marisa S
authors.initials: MS
authors.lastname: Klein-Gitelman
mesh_terms: D001323:Autoantibodies / Q000276:immunology; D015551:Autoimmunity; D046128:Fetal Therapies / Q000379:methods; D006330:Heart Defects, Congenital / Q000209:etiology* / Q000276:immunology / Q000517:prevention & control; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000150:complications / Q000151:congenital* / Q000276:immunology / Q000628:therapy; D012042:Registries
chemical_list: D001323:Autoantibodies
keywords: Autoimmune-mediated congenital heart disease; Neonatal lupus; Passive immune injury; Patient registries