title: Injectable and Cytocompatible Tough Double-Network Hydrogels through Tandem Supramolecular and Covalent Crosslinking.
abstract: Double-network theory is extended to include guest-host interactions, enabling injectability and cytcompatibility of tough hydrogels. Noncovalent interactions are used as a sacrificial network to toughen covalently crosslinked hydrogels formed from hyaluronic acid. Shear thinning of supramolecular bonds allows hydrogel injection and rapid self-healing, while gentle reaction conditions permit cell encapsulation with high viability.
authors.affiliation: Department of Bioengineering, University of Pennsylvania, 210 South 33rd Street, Philadelphia, PA, 19104, USA.
authors.forename: Christopher B
authors.initials: CB
authors.lastname: Rodell
authors.affiliation: Department of Bioengineering, University of Pennsylvania, 210 South 33rd Street, Philadelphia, PA, 19104, USA.
authors.forename: Neville N
authors.initials: NN
authors.lastname: Dusaj
authors.affiliation: Department of Bioengineering, University of Pennsylvania, 210 South 33rd Street, Philadelphia, PA, 19104, USA.
authors.forename: Christopher B
authors.initials: CB
authors.lastname: Highley
authors.affiliation: Department of Bioengineering, University of Pennsylvania, 210 South 33rd Street, Philadelphia, PA, 19104, USA. burdick2@seas.upenn.edu.
authors.forename: Jason A
authors.initials: JA
authors.lastname: Burdick
keywords: biomaterials; double networks; supramolecular chemistry; tissue engineering