title: Erosion protection benefits of stabilized SnF2dentifrice versus an arginine-sodium monofluorophosphate dentifrice: results from in vitro and in situ clinical studies.
abstract: OBJECTIVE
  The aim of these investigations was to assess the ability of two fluoride dentifrices to protect against the initiation and progression of dental erosion using a predictive in vitro erosion cycling model and a human in situ erosion prevention clinical trial for verification of effectiveness.
  
  
  METHODS
  A stabilized stannous fluoride (SnF2) dentifrice (0.454 % SnF2+ 0.077 % sodium fluoride [NaF]; total F = 1450 ppm F) [dentifrice A] and a sodium monofluorophosphate [SMFP]/arginine dentifrice (1.1 % SMFP + 1.5 % arginine; total F = 1450 ppm F) [dentifrice B] were tested in a 5-day in vitro erosion cycling model and a 10-day randomized, controlled, double-blind, two-treatment, four-period crossover in situ clinical trial. In each study, human enamel specimens were exposed to repetitive product treatments using a standardized dilution of test products followed by erosive acid challenges in a systematic fashion.
  
  
  RESULTS
  Both studies demonstrated statistically significant differences between the two products, with dentifrice A providing significantly better enamel protection in each study. In vitro, dentifrice A provided a 75.8 % benefit over dentifrice B (p < 0.05, ANOVA), while after 10 days in the in situ model, dentifrice A provided 93.9 % greater protection versus dentifrice B (p < 0.0001, general linear mixed model).
  
  
  CONCLUSIONS
  These results support the superiority of stabilized SnF2dentifrices for protecting human teeth against the initiation and progression of dental erosion.
  
  
  CONCLUSIONS
  Stabilized SnF2dentifrices may provide more significant benefits to consumers than conventional fluoride dentifrices.
authors.affiliation: School of Oral and Dental Sciences, Bristol Dental School and Hospital, Lower Maudlin Street, Bristol, BS1 2LY, UK. N.X.West@bristol.ac.uk.
authors.forename: N X
authors.initials: NX
authors.lastname: West
authors.affiliation: Procter and Gamble, Cincinnati, OH, USA.
authors.forename: T
authors.initials: T
authors.lastname: He
authors.affiliation: School of Oral and Dental Sciences, Bristol Dental School and Hospital, Lower Maudlin Street, Bristol, BS1 2LY, UK.
authors.forename: E L
authors.initials: EL
authors.lastname: Macdonald
authors.affiliation: School of Oral and Dental Sciences, Bristol Dental School and Hospital, Lower Maudlin Street, Bristol, BS1 2LY, UK.
authors.forename: J
authors.initials: J
authors.lastname: Seong
authors.affiliation: School of Oral and Dental Sciences, Bristol Dental School and Hospital, Lower Maudlin Street, Bristol, BS1 2LY, UK.
authors.forename: N
authors.initials: N
authors.lastname: Hellin
authors.affiliation: Procter and Gamble, Cincinnati, OH, USA.
authors.forename: M L
authors.initials: ML
authors.lastname: Barker
authors.affiliation: Procter and Gamble, Cincinnati, OH, USA.
authors.forename: S L
authors.initials: SL
authors.lastname: Eversole
mesh_terms: D000328:Adult; D001120:Arginine / Q000494:pharmacology*; D018592:Cross-Over Studies; D003743:Dental Enamel / Q000187:drug effects; D003802:Dentifrices / Q000737:chemistry / Q000494:pharmacology*; D004311:Double-Blind Method; D005260:Female; D005459:Fluorides / Q000494:pharmacology*; D006801:Humans; D066298:In Vitro Techniques; D008297:Male; D008875:Middle Aged; D010710:Phosphates / Q000494:pharmacology*; D014002:Tin Fluorides / Q000494:pharmacology*; D014077:Tooth Erosion / Q000517:prevention & control*; D016896:Treatment Outcome
chemical_list: D003802:Dentifrices; D010710:Phosphates; D014002:Tin Fluorides; C012980:fluorophosphate; D001120:Arginine; D005459:Fluorides
keywords: Clinical trial; Dentifrice; Erosion; Tooth wear