title: Lung cancer with concurrent EGFR mutation and ROS1 rearrangement: a case report and review of the literature.
abstract: ROS1 rearrangement has recently emerged as a new molecular subtype in non-small cell lung cancer, and is predominantly found in lung adenocarcinomas compared with other oncogenes such as EGFR, KRAS, or ALK. Patients who have both mutations are extremely rare. Here we report a 50-year-old female diagnosed with adenocarcinoma with sarcomatoid differentiation, who was shown to have EGFR and ROS1 mutations. The patient was treated surgically and received three cycles of adjuvant postoperative chemotherapy. In addition, we reviewed the previously reported cases and related literature. This presentation will provide further understanding of the underlying molecular biology and optimal treatment for non-small cell lung cancer patients with more than one driver mutation.
authors.affiliation: Department of Thoracic Surgery, The First Affiliated Hospital of Medical School of Zhejiang University, Hangzhou; Department of Thoracic Surgery, Chinese People's Armed Police Force, Zhejiang Corps Hospital, Jiaxing, Zhejiang.
authors.forename: You-Cai
authors.initials: YC
authors.lastname: Zhu
authors.affiliation: Department of Pathology, Affiliated Hospital of Academy of Military Medical Sciences, Beijing.
authors.forename: Chun-Wei
authors.initials: CW
authors.lastname: Xu
authors.affiliation: Department of Pathology, Chinese People's Armed Police Force, Zhejiang Corps Hospital, Jiaxing, Zhejiang, People's Republic of China.
authors.forename: Xiao-Qian
authors.initials: XQ
authors.lastname: Ye
authors.affiliation: Department of Pathology, Chinese People's Armed Police Force, Zhejiang Corps Hospital, Jiaxing, Zhejiang, People's Republic of China.
authors.forename: Man-Xiang
authors.initials: MX
authors.lastname: Yin
authors.affiliation: Department of Thoracic Surgery, Chinese People's Armed Police Force, Zhejiang Corps Hospital, Jiaxing, Zhejiang.
authors.forename: Jin-Xian
authors.initials: JX
authors.lastname: Zhang
authors.affiliation: Department of Thoracic Surgery, Chinese People's Armed Police Force, Zhejiang Corps Hospital, Jiaxing, Zhejiang.
authors.forename: Kai-Qi
authors.initials: KQ
authors.lastname: Du
authors.affiliation: Department of Thoracic Surgery, Chinese People's Armed Police Force, Zhejiang Corps Hospital, Jiaxing, Zhejiang.
authors.forename: Zhi-Hao
authors.initials: ZH
authors.lastname: Zhang
authors.affiliation: Department of Thoracic Surgery, The First Affiliated Hospital of Medical School of Zhejiang University, Hangzhou.
authors.forename: Jian
authors.initials: J
authors.lastname: Hu
keywords: EGFR gene mutation; ROS1 fusion gene; non-small cell lung cancer