title: A Meta-Analysis for Effects of Elevated Pre-Transplantation Serum Ferritin on the Outcomes in Patients Undergoing Hematopoietic Stem Cell Transplantation.
abstract: The level of pre-transplantation serum ferritin (SF) is one of the factors related to outcome for patients undergoing allogeneic hematopoietic stem cell transplantation. We searched PubMed and Cochrane Library databases from 2000 to 2014. The primary efficacy outcome was overall survival rate and non-relapse mortality. Twenty clinical trials were selected from 189 studies identified. The combined hazard ratio indicated a significantly lower overall survival rate and a higher non-relapse mortality rate in patients with elevated SF before transplantation. This indicates that elevated pre-transplantation SF affects outcome in patients undergoing allogeneic hematopoietic stem cell transplantation.
authors.affiliation: a Department of Hematology , The First Affiliated Hospital, Zhejiang University , Hangzhou , China.|b Department of Medicine , The Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University , Wenzhou , China.
authors.forename: Wenjian
authors.initials: W
authors.lastname: Guo
authors.affiliation: b Department of Medicine , The Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University , Wenzhou , China.
authors.forename: Aishu
authors.initials: A
authors.lastname: Dong
authors.affiliation: b Department of Medicine , The Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University , Wenzhou , China.
authors.forename: Muqing
authors.initials: M
authors.lastname: He
authors.affiliation: b Department of Medicine , The Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University , Wenzhou , China.
authors.forename: Xiaoji
authors.initials: X
authors.lastname: Lin
authors.affiliation: b Department of Medicine , The Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University , Wenzhou , China.
authors.forename: Rongxing
authors.initials: R
authors.lastname: Yao
authors.affiliation: b Department of Medicine , The Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University , Wenzhou , China.
authors.forename: Baolin
authors.initials: B
authors.lastname: Zhu
authors.affiliation: b Department of Medicine , The Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University , Wenzhou , China.
authors.forename: Xiahui
authors.initials: X
authors.lastname: Pan
authors.affiliation: a Department of Hematology , The First Affiliated Hospital, Zhejiang University , Hangzhou , China.
authors.forename: Jin
authors.initials: J
authors.lastname: Jie
mesh_terms: D015415:Biomarkers; D005293:Ferritins / Q000097:blood*; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D063868:Patient Outcome Assessment; D057234:Preoperative Period; D011379:Prognosis; D016016:Proportional Hazards Models; D017594:Publication Bias; D014184:Transplantation, Homologous
chemical_list: D015415:Biomarkers; D005293:Ferritins
keywords: Hematopoietic stem cell transplantation; Non-Relapse mortality; Overall survival; Serum ferritin