title: Humoral innate immunity at the crossroad between microbe and matrix recognition: The role of PTX3 in tissue damage.
abstract: Innate immunity is involved in regulating inflammatory and tissue repair responses to injury. In particular, humoral innate immunity plays functions related to wound clearance from tissue debris, and regulation of macrophage and stromal cell activities. PTX3, a component of humoral innate immunity, orchestrates tissue repair by interacting with plasminogen and fibrin. Fluid-phase molecules of innate immunity interact with elements of the extracellular matrix, and some of the latter display opsonic activity against certain bacterial species. Thus, recognition of extracellular matrix and microbial components is a recurrent theme in the humoral arm of the innate immune system.
authors.affiliation: Humanitas Clinical and Research Center, Rozzano, Milan 20089, Italy.
authors.forename: Andrea
authors.initials: A
authors.lastname: Doni
authors.affiliation: Centro Ricerca Tettamanti, Department of Pediatrics, University of Milano-Bicocca, Fondazione MBBM/San Gerardo Hospital, Monza 20900, Italy.
authors.forename: Giovanna
authors.initials: G
authors.lastname: D'Amico
authors.affiliation: Humanitas Clinical and Research Center, Rozzano, Milan 20089, Italy.
authors.forename: Diego
authors.initials: D
authors.lastname: Morone
authors.affiliation: Humanitas Clinical and Research Center, Rozzano, Milan 20089, Italy; Humanitas University, Rozzano, Milan 20089, Italy. Electronic address: alberto.mantovani@humanitasresearch.it.
authors.forename: Alberto
authors.initials: A
authors.lastname: Mantovani
authors.affiliation: Humanitas Clinical and Research Center, Rozzano, Milan 20089, Italy.
authors.forename: Cecilia
authors.initials: C
authors.lastname: Garlanda
mesh_terms: D000818:Animals; D001419:Bacteria / Q000276:immunology*; D002097:C-Reactive Protein / Q000378:metabolism*; D005109:Extracellular Matrix / Q000378:metabolism*; D006801:Humans; D056724:Immunity, Humoral; D007113:Immunity, Innate; D009419:Nerve Tissue Proteins / Q000378:metabolism*; D014945:Wound Healing; D000099153:Pentraxins
chemical_list: D002097:C-Reactive Protein; D009419:Nerve Tissue Proteins; D000099153:Pentraxins
keywords: Inflammation; Innate immunity; Pattern recognition molecule; Pentraxin-3 (PTX3); Tissue repair