title: Loss of mtch2 function impairs early development of liver, intestine and visceral adipocytes in zebrafish larvae.
abstract: The mitochondrial carrier homologue 2 (MTCH2) has been shown to be essential for embryogenesis in mice, and variants in the MTCH2 locus have been linked to obesity in humans. Here, we investigated the importance of mtch2 for embryogenesis and adipocyte formation in zebrafish in vivo. We show that mtch2 is conserved in zebrafish and broadly expressed during embryogenesis. Knock-down of mtch2 results in impaired development of liver and intestine, and is associated with a reduced number of adipocytes and impaired postembryonic growth. The findings indicate an essential role for mtch2 during organ development and adipogenesis in vivo.
authors.affiliation: Center for Pediatric Research Leipzig (CPL), University Hospital for Children and Adolescents, University of Leipzig, Germany.|Medical Center AdiposityDiseases (IFB), University of Leipzig, Germany.
authors.forename: Kathrin
authors.identifier: 0000-0002-6878-6033
authors.initials: K
authors.lastname: Landgraf
authors.affiliation: Center for Pediatric Research Leipzig (CPL), University Hospital for Children and Adolescents, University of Leipzig, Germany.
authors.forename: Ariane
authors.initials: A
authors.lastname: Strobach
authors.affiliation: Center for Pediatric Research Leipzig (CPL), University Hospital for Children and Adolescents, University of Leipzig, Germany.
authors.forename: Wieland
authors.initials: W
authors.lastname: Kiess
authors.affiliation: Center for Pediatric Research Leipzig (CPL), University Hospital for Children and Adolescents, University of Leipzig, Germany.|Medical Center AdiposityDiseases (IFB), University of Leipzig, Germany.
authors.forename: Antje
authors.initials: A
authors.lastname: Körner
mesh_terms: D017667:Adipocytes / Q000166:cytology / Q000378:metabolism; D050156:Adipogenesis / Q000235:genetics; D000818:Animals; D047108:Embryonic Development / Q000235:genetics*; D018507:Gene Expression Regulation, Developmental; D055785:Gene Knockdown Techniques; D006801:Humans; D007413:Intestinal Mucosa / Q000378:metabolism; D007422:Intestines / Q000254:growth & development; D007814:Larva / Q000235:genetics / Q000254:growth & development; D008099:Liver / Q000254:growth & development / Q000378:metabolism*; D051379:Mice; D033681:Mitochondrial Membrane Transport Proteins / Q000235:genetics*; D015027:Zebrafish / Q000235:genetics* / Q000254:growth & development
chemical_list: D033681:Mitochondrial Membrane Transport Proteins; C550380:Mtch2 protein, mouse
keywords: MTCH2; adipocyte; embryogenesis; morpholino; organogenesis; zebrafish