title: Continued Studies on the Effects of Simazine on the Liver Histological Structure and Metamorphosis in the Developing Xenopus laevis.
abstract: This study continued our previous work (Sai et al. in Bull Environ Contam Toxicol 95:157-163, 2015a) by analysing the effects of simazine on the liver histological structure and metamorphosis in the developing Xenopus laevis. Tadpoles (Nieuwkoop-Faber stage 46) were exposed to simazine at 0.1, 1.2, 11.0 and 100.9 μg/L for 100 days. When tadpoles were exposed to simazine at 11.0 and 100.9 µg/L, an increased mortality and damaged liver tissues were observed together with significant inhibition of percent of X. laevis completing metamorphosis on days 80 and 90 and prolonged time of completing metamorphosis. On the other hand, we found that simazine has no significant effects on liver weight and altered hepatosomatic index. Results of this study may be considered to inform risk assessment of the effects of simazine on the development of X. laevis.
authors.affiliation: Department of Toxicology, Shandong Academy of Occupational Health and Occupational Medicine, Jinan, 250062, Shandong, China. sailinlin2009@163.com.
authors.forename: Linlin
authors.initials: L
authors.lastname: Sai
authors.affiliation: China Shandong Medical College, Jinan, 250002, Shandong, China.
authors.forename: Binpeng
authors.initials: B
authors.lastname: Qu
authors.affiliation: Shandong Provincial Chest Hospital, Jinan, 250013, Shandong, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Li
authors.affiliation: Department of Toxicology, Shandong Academy of Occupational Health and Occupational Medicine, Jinan, 250062, Shandong, China.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Jia
authors.affiliation: Department of Toxicology, Shandong Academy of Occupational Health and Occupational Medicine, Jinan, 250062, Shandong, China.
authors.forename: Cunxiang
authors.initials: C
authors.lastname: Bo
authors.affiliation: Weihai Wendeng Center Hospital, Weihai, 264400, Shandong, China.
authors.forename: Yanzhong
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Department of Toxicology, Shandong Academy of Occupational Health and Occupational Medicine, Jinan, 250062, Shandong, China.
authors.forename: Gongchang
authors.initials: G
authors.lastname: Yu
authors.affiliation: Department of Toxicology, Shandong Academy of Occupational Health and Occupational Medicine, Jinan, 250062, Shandong, China.
authors.forename: Lin
authors.initials: L
authors.lastname: Xie
authors.affiliation: Department of Toxicology, Shandong Academy of Occupational Health and Occupational Medicine, Jinan, 250062, Shandong, China. 18653199120@163.com.
authors.forename: Ling
authors.initials: L
authors.lastname: Li
authors.affiliation: The University of Queensland, National Research Centre for Environmental Toxicology-Entox, Brisbane, 4108, Australia.
authors.forename: Jack C
authors.initials: JC
authors.lastname: Ng
authors.affiliation: The University of Queensland, National Research Centre for Environmental Toxicology-Entox, Brisbane, 4108, Australia.
authors.forename: Cheng
authors.initials: C
authors.lastname: Peng
mesh_terms: D000818:Animals; D004305:Dose-Response Relationship, Drug; D006540:Herbicides / Q000633:toxicity; D007814:Larva / Q000187:drug effects* / Q000254:growth & development*; D008099:Liver / Q000187:drug effects* / Q000473:pathology*; D008675:Metamorphosis, Biological / Q000187:drug effects*; D009929:Organ Size / Q000187:drug effects; D012839:Simazine / Q000633:toxicity*; D014982:Xenopus laevis / Q000254:growth & development*
chemical_list: D006540:Herbicides; D012839:Simazine
keywords: Ecological effect; Endocrine disrupting chemicals; Frog; Herbicide; Organic damage