title: Effect of elcatonin versus nonsteroidal anti-inflammatory medications for acute back pain in patients with osteoporotic vertebral fracture: a multiclinic randomized controlled trial.
abstract: The aim of this study was to compare the efficacy of elcatonin injections and oral nonsteroidal anti-inflammatory drugs (NSAIDs) for patients with osteoporosis who have acute lumbar pain after experiencing new vertebral compression fractures. Two hundred twenty-eight Japanese female patients (mean age 77.3 years) with acute lumbar pain from osteoporotic vertebral fractures were randomly divided into two groups. Patients in one group were given an NSAID (NSAIDs group) and patients in the other group were given weekly intramuscular injections of 20 units of elcatonin (elcatonin group). All patients underwent follow-up examinations up to 6 weeks from the start of the trial. Outcome measures were the level of functional impairment according to the Japan Questionnaire for Osteoporotic Pain (JQ22), the Roland-Morris Disability Questionnaire (RDQ), and a visual analog scale (VAS) of pain intensity. Statistical analyses focused on (1) the time course of pain and functional level using linear mixed effects models to analyze the longitudinal data and (2) the effectiveness of elcatonin injection with mean difference values and 95 % confidence intervals. Significant differences were seen over time between the initial values and the postintervention values (4 and 6 weeks) in JQ22, RDQ, and VAS scores (effect size d > 0.4) in each group. The mean differences between the elcatonin group and the NSAIDs group in each measure at 4 and 6 weeks were -4.8 and -8.3 for the JQ22, -1.3 and -2.6 for the RDQ, and -11.3 and -11.5 for the VAS, shifted to elcatonin. Once weekly elcatonin injection was more effective than NSAIDs for treating acute lumbar pain and improving mobility in Japanese women with osteoporotic vertebral fractures.
authors.affiliation: Division of Orthopedic Surgery, Department of Regenerative and Transplant Medicine, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan. endless@med.niigata-u.ac.jp.
authors.forename: Naoto
authors.initials: N
authors.lastname: Endo
authors.affiliation: Fujino Orthopaedic Clinic, Fujino, Japan.
authors.forename: Keiji
authors.initials: K
authors.lastname: Fujino
authors.affiliation: Fukuoka Clinic, Fukuoka, Japan.
authors.forename: Tokuhide
authors.initials: T
authors.lastname: Doi
authors.affiliation: National Rehabilitation Center for Persons with Disabilities, Tokyo, Japan.
authors.forename: Masami
authors.initials: M
authors.lastname: Akai
authors.affiliation: Department of Orthopaedic Surgery, Jichi Medical School, Shimotsuke, Japan.
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Hoshino
authors.affiliation: Tamana Central Hospital, Tamana, Japan.
authors.forename: Tetsuo
authors.initials: T
authors.lastname: Nakano
authors.affiliation: National Rehabilitation Center for Persons with Disabilities, Tokyo, Japan.
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Iwaya
mesh_terms: D000208:Acute Disease; D000368:Aged; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*; D001416:Back Pain / Q000188:drug therapy*; D002116:Calcitonin / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use; D016001:Confidence Intervals; D005260:Female; D006801:Humans; D007564:Japan; D008279:Magnetic Resonance Imaging; D058866:Osteoporotic Fractures / Q000150:complications / Q000188:drug therapy*; D016103:Spinal Fractures / Q000150:complications / Q000188:drug therapy*; D011795:Surveys and Questionnaires; D016896:Treatment Outcome
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D002116:Calcitonin; C012755:elcatonin
keywords: Calcitonin (or elcatonin); Lumbar pain; Osteoporosis; Randomized controlled trial; Vertebral fracture