title: Safety Assessment of Hydroxypropyl Bis(N-Hydroxyethyl-p-Phenylenediamine) HCl as Used in Cosmetics.
abstract: The Cosmetic Ingredient Review Expert Panel (CIR Panel) reviewed the safety of hydroxypropyl bis(N-Hydroxyethyl-p-Phenylenediamine) HCl, which functions as an oxidative hair dye ingredient. The Panel considered relevant animal and human data provided in this safety assessment and concluded that hydroxypropyl bis(N-hydroxyethyl-p-phenylenediamine) HCl is safe for use in oxidative hair dye formulations as described in this safety assessment.
authors.affiliation: Cosmetic Ingredient Review, Washington, DC, USA.
authors.forename: Lillian C
authors.initials: LC
authors.lastname: Becker
authors.affiliation: Cosmetic Ingredient Review, Washington, DC, USA.
authors.forename: Wilma F
authors.initials: WF
authors.lastname: Bergfeld
authors.affiliation: Cosmetic Ingredient Review, Washington, DC, USA.
authors.forename: Donald V
authors.initials: DV
authors.lastname: Belsito
authors.affiliation: Cosmetic Ingredient Review, Washington, DC, USA.
authors.forename: Ronald A
authors.initials: RA
authors.lastname: Hill
authors.affiliation: Cosmetic Ingredient Review, Washington, DC, USA.
authors.forename: Curtis D
authors.initials: CD
authors.lastname: Klaassen
authors.affiliation: Cosmetic Ingredient Review, Washington, DC, USA.
authors.forename: Daniel C
authors.initials: DC
authors.lastname: Liebler
authors.affiliation: Cosmetic Ingredient Review, Washington, DC, USA.
authors.forename: James G
authors.initials: JG
authors.lastname: Marks
authors.affiliation: Cosmetic Ingredient Review, Washington, DC, USA.
authors.forename: Ronald C
authors.initials: RC
authors.lastname: Shank
authors.affiliation: Cosmetic Ingredient Review, Washington, DC, USA.
authors.forename: Thomas J
authors.initials: TJ
authors.lastname: Slaga
authors.affiliation: Cosmetic Ingredient Review, Washington, DC, USA.
authors.forename: Paul W
authors.initials: PW
authors.lastname: Snyder
authors.affiliation: Cosmetic Ingredient Review, Washington, DC, USA.
authors.forename: F Alan
authors.initials: FA
authors.lastname: Andersen
mesh_terms: D000818:Animals; D003257:Consumer Product Safety; D006202:Hair Dyes / Q000378:metabolism / Q000633:toxicity*; D006801:Humans; D007509:Irritants / Q000633:toxicity; D009152:Mutagenicity Tests; D010655:Phenylenediamines / Q000633:toxicity*; D011412:Propanolamines / Q000633:toxicity*; D023382:Toxicity Tests, Acute
chemical_list: D006202:Hair Dyes; D007509:Irritants; D010655:Phenylenediamines; D011412:Propanolamines; C000625873:hydroxypropyl bis(N-hydroxyethyl-p-phenylenediamine)
keywords: hair dye; hydroxypropyl bis(N-hydroxyethyl-p-phenylenediamine) HCl; phenylenediamine