title: Shipping Drug Resistance: Extracellular Vesicles in Ovarian Cancer.
abstract: Ovarian cancer is a deadly disease, largely because of relapse and chemotherapy resistance. Common genetic mechanisms causing drug resistance have not been identified. A recent study unravels a novel and unexpected pathway involving the transfer of microvesicle-encapsulated miRNA from omental adipocytes and fibroblasts, to cancer cells.
authors.affiliation: Innate Immunity Group, Department I of Internal Medicine, University Hospital of Cologne, Cologne, Germany; Experimental Tumor Research, Center for Tumor Biology and Immunology, Clinic for Hematology, Oncology, and Immunology, Philipps University, Hans-Meerwein-Strasse 3, 35043 Marburg, Germany. Electronic address: elke.pogge@uk-koeln.de.
authors.forename: Elke Pogge von
authors.initials: EPV
authors.lastname: Strandmann
authors.affiliation: Institute of Molecular Biology and Tumor Research, Center for Tumor Biology and Immunology, Philipps University, Hans-Meerwein-Strasse 3, 35043 Marburg, Germany.
authors.forename: Rolf
authors.initials: R
authors.lastname: Müller
mesh_terms: D017667:Adipocytes / Q000187:drug effects / Q000378:metabolism*; D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology; D001952:Bridged-Ring Compounds / Q000494:pharmacology; D019008:Drug Resistance, Neoplasm; D000067128:Extracellular Vesicles / Q000187:drug effects / Q000235:genetics / Q000378:metabolism*; D005260:Female; D005347:Fibroblasts / Q000187:drug effects / Q000378:metabolism*; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D051379:Mice; D035683:MicroRNAs / Q000235:genetics / Q000378:metabolism*; D010051:Ovarian Neoplasms / Q000188:drug therapy / Q000235:genetics / Q000378:metabolism*; D010053:Ovary / Q000187:drug effects / Q000378:metabolism; D034443:RNA Transport; D043823:Taxoids / Q000494:pharmacology
chemical_list: D000970:Antineoplastic Agents; D001952:Bridged-Ring Compounds; D035683:MicroRNAs; D043823:Taxoids; C080625:taxane