title: Pharmacokinetics of butafosfan after intravenous and intramuscular administration in piglets.
abstract: The pharmacokinetics and bioavailability of butafosfan in piglets were investigated following intravenous and intramuscular administration at a single dose of 10 mg/kg body weight. Plasma concentration-time data and relevant parameters were best described by noncompartmental analysis after intravenous and intramuscular injection. The data were analyzed through WinNolin 6.3 software. After intravenous administration, the mean pharmacokinetic parameters were determined as T1/2λzof 3.30 h, Cl of 0.16 L kg/h, AUC of 64.49 ± 15.07 μg h/mL, Vssof 0.81 ± 0.44/kg, and MRT of 1.51 ± 0.27 h. Following intramuscular administration, the Cmax(28.11 μg/mL) was achieved at Tmax(0.31 h) with an absolute availability of 74.69%. Other major parameters including AUC and MRT were 48.29 ± 21.67 μg h/mL and 1.74 ± 0.29 h, respectively.
authors.affiliation: Department of Veterinary Pharmacology and Toxicology, China Agricultural University, Beijing, China.|Key Laboratory of Detection for Veterinary Drug Residue and Illegal Additive, Ministry of Agriculture, Beijing, China.|Laboratory of Quality & Safety Risk Assessment for Animal Products on Chemical Hazards (Beijing), Ministry of Agriculture, Beijing, China.
authors.forename: F
authors.initials: F
authors.lastname: Sun
authors.affiliation: Department of Veterinary Pharmacology and Toxicology, China Agricultural University, Beijing, China.|Key Laboratory of Detection for Veterinary Drug Residue and Illegal Additive, Ministry of Agriculture, Beijing, China.|Laboratory of Quality & Safety Risk Assessment for Animal Products on Chemical Hazards (Beijing), Ministry of Agriculture, Beijing, China.
authors.forename: J
authors.initials: J
authors.lastname: Wang
authors.affiliation: Department of Veterinary Pharmacology and Toxicology, China Agricultural University, Beijing, China.
authors.forename: S
authors.initials: S
authors.lastname: Yang
authors.affiliation: Department of Veterinary Pharmacology and Toxicology, China Agricultural University, Beijing, China.
authors.forename: S
authors.initials: S
authors.lastname: Zhang
authors.affiliation: Department of Veterinary Pharmacology and Toxicology, China Agricultural University, Beijing, China.|Key Laboratory of Detection for Veterinary Drug Residue and Illegal Additive, Ministry of Agriculture, Beijing, China.|Laboratory of Quality & Safety Risk Assessment for Animal Products on Chemical Hazards (Beijing), Ministry of Agriculture, Beijing, China.
authors.forename: J
authors.initials: J
authors.lastname: Shen
authors.affiliation: Department of Veterinary Pharmacology and Toxicology, China Agricultural University, Beijing, China.|Key Laboratory of Detection for Veterinary Drug Residue and Illegal Additive, Ministry of Agriculture, Beijing, China.|Laboratory of Quality & Safety Risk Assessment for Animal Products on Chemical Hazards (Beijing), Ministry of Agriculture, Beijing, China.
authors.forename: C
authors.initials: C
authors.lastname: Xingyuan
mesh_terms: D061605:Administration, Intravenous; D000818:Animals; D019540:Area Under Curve; D002082:Butylamines / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D006207:Half-Life; D007273:Injections, Intramuscular; D009943:Organophosphorus Compounds / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D010721:Phosphinic Acids / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D013552:Swine / Q000097:blood*
chemical_list: D002082:Butylamines; D009943:Organophosphorus Compounds; D010721:Phosphinic Acids; C000613005:butafosfan