title: Control of White Spot Lesions with Use of Fluoride Varnish or Chlorhexidine Gel During Orthodontic Treatment A Randomized Clinical Trial.
abstract: OBJECTIVE
  To compare the effectiveness of fluoride varnish and 2% chlorhexidine gel for controlling active white spot lesions (WSLs) adjacent to orthodontic brackets.
  
  
  METHODS
  Thirty-five orthodontic patients (17.2 ± 2.3 years old) presenting 60 WSLs adjacent to orthodontic brackets were enrolled in this randomized, blind, 3-armed and controlled clinical trial. The patients were randomly allocated to 1 of 3 arms: (1) two applications of 5% NaF varnish- F, with one-week interval, (2) two applications of 2% chlorhexidine gel-CHX, with one-week interval and (3) usual home care-control (CO). The WSLs were scored by using a DIAGNOdent pen. An independent examiner scored the surfaces using Nyvad criteria for caries assessment.
  
  
  RESULTS
  A total of thirty patients presenting 51 lesions completed the study. All treatments reduced the fluorescence values during the experimental period; however, F induced faster remineralization than CHX. After 3 months, 70.58 % were inactive considering all groups. DIAGNOdent pen and Nyvad presented a significant correlation.
  
  
  CONCLUSIONS
  After 3 months of treatment, F, CHX and CO were capable of controlling the WSLs adjacent to the orthodontic brackets. However, the treatment with F was capable of controlling the progression of the WSLs in a shorter period of time.
authors.forename: M
authors.initials: M
authors.lastname: Restrepo
authors.forename: D G
authors.initials: DG
authors.lastname: Bussaneli
authors.forename: F
authors.initials: F
authors.lastname: Jeremias
authors.forename: R C L
authors.initials: RC
authors.lastname: Cordeiro
authors.forename: D B
authors.initials: DB
authors.lastname: Raveli
authors.forename: A C
authors.initials: AC
authors.lastname: Magalhães
authors.forename: C
authors.initials: C
authors.lastname: Candolo
authors.forename: L
authors.initials: L
authors.lastname: Santos-Pinto
mesh_terms: D000293:Adolescent; D002710:Chlorhexidine / Q000737:chemistry / Q000627:therapeutic use*; D003116:Color; D003729:Dental Care / Q000379:methods; D005260:Female; D005459:Fluorides / Q000627:therapeutic use*; D005782:Gels / Q000737:chemistry; D006801:Humans; D008297:Male; D010150:Paint; D014087:Tooth Movement Techniques; D055815:Young Adult
chemical_list: D005782:Gels; D005459:Fluorides; D002710:Chlorhexidine
keywords: Chlorhexidine; Dental Caries; Fluorescence; Fluoride; Orthodontic Appliances; Tooth remineralization