title: Recent highlights of Chinese herbs in treatment of allergic disease: Acting via mitogen-activated protein kinase signal pathway.
abstract: The histamine receptor antagonists in the treatment of allergic disease have limitations. The treatments of Chinese herbs have some curative effects on allergic skin lesions. Present research indicates that the mitogen-activated protein kinase (MAPK) signaling pathway might be equally important in allergic reactions. It was found that the inhibition of MAPK signaling pathways might relieve allergy symptoms, and some herbs can inhibit the MAPK pathway, which yields anti-allergy effects. Chinese medicines (CMs) have immense potential in the development of treatments for allergic disease.
authors.affiliation: Department of Dermatology, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China.
authors.forename: Xu-Feng
authors.initials: XF
authors.lastname: He
authors.affiliation: Department of Dermatology, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China.
authors.forename: Wei-Dong
authors.initials: WD
authors.lastname: Pan
authors.affiliation: Department of Dermatology, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China.
authors.forename: Yi-Li
authors.initials: YL
authors.lastname: Yao
authors.affiliation: Department of Dermatology, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China. happy2003_1@msn.com.
authors.forename: Hui-Min
authors.initials: HM
authors.lastname: Zhang
mesh_terms: D000818:Animals; D004365:Drugs, Chinese Herbal / Q000494:pharmacology / Q000627:therapeutic use*; D006801:Humans; D006967:Hypersensitivity / Q000188:drug therapy* / Q000201:enzymology* / Q000276:immunology; D056747:Immunomodulation / Q000187:drug effects; D020935:MAP Kinase Signaling System / Q000187:drug effects; D020928:Mitogen-Activated Protein Kinases / Q000378:metabolism*; D016896:Treatment Outcome
chemical_list: D004365:Drugs, Chinese Herbal; D020928:Mitogen-Activated Protein Kinases
keywords: Chinese medicines; allergic disease; mitogen-activated protein kinase signal pathway