title: Preparation of antioxidant active films based on chitosan: diffusivity study of α-tocopherol into food simulants.
abstract: New active films based on chitosan and polycaprolactone blends and containing α-tocopherol were designed for food packaging applications. Mechanical properties, stability against temperature and swelling degree in 50 % ethanol (v/v) were evaluated. Migration kinetics of α-tocopherol from the developed films into butter and food simulants [50 % ethanol (v/v), 95 % ethanol (v/v), and isooctane] at different temperatures were studied. α-Tocopherol was quantified in the food simulants by means of high performance liquid chromatography with diode-array detection at 292 nm. The proposed method exhibited a good sensitivity with a limit of detection of 0.1 mg/L. The kinetics release of α-tocopherol was characterized by determining the partition and the diffusion coefficients by using a mathematical modeling based on Fick's Second Law. The diffusion coefficients obtained ranged between 1.03 × 10(-13) and 2.24 × 10(-12) cm(2)/s for 95 % ethanol (v/v) at 4 and 20 °C, respectively. Developed films maintained the antioxidant activity for more than 20 days.
authors.affiliation: Department of Analytical Chemistry, Nutrition and Food Science, University of Santiago de Compostela, Campus Vida s/n, 15782 Santiago de Compostela, La Coruña Spain.
authors.forename: P
authors.initials: P
authors.lastname: Otero-Pazos
authors.affiliation: Department of Analytical Chemistry, Nutrition and Food Science, University of Santiago de Compostela, Campus Vida s/n, 15782 Santiago de Compostela, La Coruña Spain.
authors.forename: R
authors.initials: R
authors.lastname: Sendón
authors.affiliation: Department of Pharmacy and Pharmaceutical Technology, Faculty of Pharmacy, University of Santiago de Compostela, Campus Vida s/n, 15782 Santiago de Compostela, La Coruña Spain.
authors.forename: B
authors.initials: B
authors.lastname: Blanco-Fernandez
authors.affiliation: Department of Pharmacy and Pharmaceutical Technology, Faculty of Pharmacy, University of Santiago de Compostela, Campus Vida s/n, 15782 Santiago de Compostela, La Coruña Spain.
authors.forename: S
authors.initials: S
authors.lastname: Blanco-Dorado
authors.affiliation: Department of Pharmacy and Pharmaceutical Technology, Faculty of Pharmacy, University of Santiago de Compostela, Campus Vida s/n, 15782 Santiago de Compostela, La Coruña Spain.
authors.forename: C
authors.initials: C
authors.lastname: Alvarez-Lorenzo
authors.affiliation: Department of Pharmacy and Pharmaceutical Technology, Faculty of Pharmacy, University of Santiago de Compostela, Campus Vida s/n, 15782 Santiago de Compostela, La Coruña Spain.
authors.forename: A
authors.initials: A
authors.lastname: Concheiro
authors.affiliation: GAIKER Technological Center, 8170 Zamudio, Spain.
authors.forename: I
authors.initials: I
authors.lastname: Angulo
authors.affiliation: Department of Analytical Chemistry, Nutrition and Food Science, University of Santiago de Compostela, Campus Vida s/n, 15782 Santiago de Compostela, La Coruña Spain.
authors.forename: P
authors.initials: P
authors.lastname: Paseiro-Losada
authors.affiliation: Department of Analytical Chemistry, Nutrition and Food Science, University of Santiago de Compostela, Campus Vida s/n, 15782 Santiago de Compostela, La Coruña Spain.
authors.forename: A
authors.initials: A
authors.lastname: Rodríguez-Bernaldo de Quirós
keywords: Active food packaging; Chitosan; Migration kinetics; Partition and diffusion coefficients; α-Tocopherol