title: Controlled drug release to cancer cells from modular one-photon visible light-responsive micellar system.
abstract: We present a one-photon visible light-responsive micellar system for efficient, on-demand delivery of small molecules. Release is mediated by a novel class of photochromic material - donor-acceptor Stenhouse adducts (DASAs). We demonstrate controlled delivery of small molecules such as the chemotherapeutic agent (paclitaxel) to human breast cancer cells triggered by micellar switching with low intensity, visible light.
authors.affiliation: Department of Chemistry and Biochemistry, University of California, Santa Barbara, California 93106, USA. javier@chem.ucsb.edu.
authors.forename: Saemi O
authors.initials: SO
authors.lastname: Poelma
authors.affiliation: Materials Department, Materials Research Laboratory, University of California, Santa Barbara, California 93106, USA.
authors.forename: Seung Soo
authors.initials: SS
authors.lastname: Oh
authors.affiliation: Department of Chemistry and Biochemistry, University of California, Santa Barbara, California 93106, USA. javier@chem.ucsb.edu.
authors.forename: Sameh
authors.initials: S
authors.lastname: Helmy
authors.affiliation: Materials Department, Materials Research Laboratory, University of California, Santa Barbara, California 93106, USA.
authors.forename: Abigail S
authors.initials: AS
authors.lastname: Knight
authors.affiliation: Materials Department, Materials Research Laboratory, University of California, Santa Barbara, California 93106, USA.
authors.forename: G Leslie
authors.initials: GL
authors.lastname: Burnett
authors.affiliation: Materials Department, Materials Research Laboratory, University of California, Santa Barbara, California 93106, USA and Department of Mechanical Engineering, University of California, Santa Barbara, California 93106, USA.
authors.forename: H Tom
authors.initials: HT
authors.lastname: Soh
authors.affiliation: Department of Chemistry and Biochemistry, University of California, Santa Barbara, California 93106, USA. javier@chem.ucsb.edu and Materials Department, Materials Research Laboratory, University of California, Santa Barbara, California 93106, USA.
authors.forename: Craig J
authors.initials: CJ
authors.lastname: Hawker
authors.affiliation: Department of Chemistry and Biochemistry, University of California, Santa Barbara, California 93106, USA. javier@chem.ucsb.edu.
authors.forename: Javier
authors.initials: J
authors.lastname: Read de Alaniz