title: ABO blood type is associated with ovarian reserve in Chinese women with subfertility.
abstract: Ovarian reserve reflects both the quantity and quality of oocytes available for procreation, and is affected by many known and unknown factors. ABO blood type is related to a number of infertility processes, but it is unclear whether and how ABO blood type affects ovarian reserve. Here, we explored the relationship between ABO blood type and ovarian reserve in Chinese women with subfertility. Day-3 serum follicle-stimulating hormone (FSH) levels and blood type were examined in 14,875 women who underwent IVF or ICSI treatment. Blood type proportions in the patient population were as follows: 30.98% type A, 24.54% type B, 7.57% type AB, and 36.91% type O. A higher percentage of women with diminished ovarian reserve (DOR) were blood type O, while a lower percentage had the B antigen (B and AB). Multiple logistic regression analysis revealed that blood type O was associated with a greater risk of DOR than blood type B and B antigen-positive types. By contrast, the B antigen (B and AB) was associated with a lower incidence of DOR than blood type O. These results suggest that blood type O is a risk factor for DOR while the B antigen (blood type B or AB) is a protective factor for ovarian reserve in Chinese women with subfertility. Further studies are needed to confirm this effect and identify the underlying mechanisms.
authors.affiliation: Reproductive Medicine Center, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, People's Republic of China.
authors.forename: Liangshan
authors.initials: L
authors.lastname: Mu
authors.affiliation: Reproductive Medicine Center, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, People's Republic of China.
authors.forename: Wumin
authors.initials: W
authors.lastname: Jin
authors.affiliation: Reproductive Medicine Center, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, People's Republic of China.
authors.forename: Haiyan
authors.initials: H
authors.lastname: Yang
authors.affiliation: Reproductive Medicine Center, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, People's Republic of China.
authors.forename: Xia
authors.initials: X
authors.lastname: Chen
authors.affiliation: Reproductive Medicine Center, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, People's Republic of China.
authors.forename: Jiexue
authors.initials: J
authors.lastname: Pan
authors.affiliation: Reproductive Medicine Center, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, People's Republic of China.
authors.forename: Jia
authors.initials: J
authors.lastname: Lin
authors.affiliation: Reproductive Medicine Center, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, People's Republic of China.
authors.forename: Peiyu
authors.initials: P
authors.lastname: Wang
authors.affiliation: Reproductive Medicine Center, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, People's Republic of China.
authors.forename: Xuefeng
authors.initials: X
authors.lastname: Huang
mesh_terms: D000017:ABO Blood-Group System / Q000235:genetics*; D000328:Adult; D044466:Asian People; D005260:Female; D006801:Humans; D007246:Infertility / Q000235:genetics*; D065851:Ovarian Reserve / Q000235:genetics*
chemical_list: D000017:ABO Blood-Group System
keywords: FSH; Pathology Section; blood type; infertility; ovarian reserve