title: Antibiotics Prophylaxis for Operative Hysteroscopy.
abstract: To evaluate the incidence of infectious complications and effect of prophylactic antibiotic administration during operative hysteroscopic procedures.
  
  
  
  A multicentric randomized controlled trial was conducted between January 2012 and December 2013. Women (n = 180) affected by endometrial hyperplasia, myomas, or endometrial polyps undergoing operative hysteroscopy were randomized to receive cefazolin 2 g intravenously 30 minutes prior to the procedure (n = 91) and no treatment (n = 89).
  
  
  
  No statistical difference in terms of postoperative fever (2.4% vs 2.3%, P = .99), endometritis (0% vs 0%), pain (6.0% vs 10.4%, P = .40), cervicitis-vaginitis (0% vs 0%), pelvic abscess (0% vs 0%), pelvic inflammatory disease (0% vs 0%), and bleeding (0% vs 0%) was noticed. No statistical difference in terms of side effects attributable to antibiotic prophylaxis such as allergy (0% vs 4.8%, P = .12), nausea (10.7% vs 17.4%, P = .27), vomiting (3.6% vs 4.6%, P = .99), diarrhea (4.8% vs 5.4%, P = .99), cephalea (9.5% vs 3.5%, P = .13), dizziness (4.8% vs 2.3%, P = .44), and meteorism (5.4% vs 3.4%, P = .99) was noticed.
  
  
  
  The results of the current study support the recommendation not to prescribe routine antibiotic prophylaxis prior to operative hysteroscopy.
authors.affiliation: 1 Department of Gynecology, Obstetrics, and Urology, Umberto I, Sapienza University of Rome, Rome, Italy.
authors.forename: Ludovico
authors.initials: L
authors.lastname: Muzii
authors.affiliation: 1 Department of Gynecology, Obstetrics, and Urology, Umberto I, Sapienza University of Rome, Rome, Italy.
authors.forename: Violante
authors.initials: V
authors.lastname: Di Donato
authors.affiliation: 1 Department of Gynecology, Obstetrics, and Urology, Umberto I, Sapienza University of Rome, Rome, Italy.
authors.forename: Terenzio
authors.initials: T
authors.lastname: Boni
authors.affiliation: 2 Department of Obstetrics and Gynecology, Catholic University of the Sacred Heart, Rome, Italy.
authors.forename: Raffaele
authors.initials: R
authors.lastname: Gaglione
authors.affiliation: 2 Department of Obstetrics and Gynecology, Catholic University of the Sacred Heart, Rome, Italy.
authors.forename: Riccardo
authors.initials: R
authors.lastname: Marana
authors.affiliation: 3 Arbor Vitae Center for Endoscopic Gynecology, Clinica Nuova Villa Claudia, Rome, Italy.
authors.forename: Ivan
authors.initials: I
authors.lastname: Mazzon
authors.affiliation: 1 Department of Gynecology, Obstetrics, and Urology, Umberto I, Sapienza University of Rome, Rome, Italy.
authors.forename: Ludovica
authors.initials: L
authors.lastname: Imperiale
authors.affiliation: 1 Department of Gynecology, Obstetrics, and Urology, Umberto I, Sapienza University of Rome, Rome, Italy.
authors.forename: Caterina
authors.initials: C
authors.lastname: De Medici
authors.affiliation: 4 Department of Obstetrics and Gynecology, University of Rome Campus Bio-Medico, Rome, Italy.
authors.forename: Alfonso
authors.initials: A
authors.lastname: Ruggiero
authors.affiliation: 1 Department of Gynecology, Obstetrics, and Urology, Umberto I, Sapienza University of Rome, Rome, Italy.
authors.forename: Pierluigi Benedetti
authors.initials: PB
authors.lastname: Panici
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D019072:Antibiotic Prophylaxis; D002437:Cefazolin / Q000627:therapeutic use; D004714:Endometrial Hyperplasia / Q000601:surgery*; D005260:Female; D006801:Humans; D015907:Hysteroscopy / Q000379:methods*; D007889:Leiomyoma / Q000601:surgery*; D008875:Middle Aged; D011127:Polyps / Q000601:surgery*; D016896:Treatment Outcome; D014594:Uterine Neoplasms / Q000601:surgery*
chemical_list: D000900:Anti-Bacterial Agents; D002437:Cefazolin
keywords: antibiotic prophylaxis; operative hysteroscopy; pelvic endoscopy