title: Association of interleukin-10 polymorphisms with risk factors of Alzheimer's disease and other dementias (SADEM study).
abstract: Some studies have reported a genetic association between single nucleotide polymorphisms (SNPs) in the promoter region of Interleukin (IL) 10 and Alzheimer's disease (AD), with conflicting results. To further investigate the proposed association and to clarify the role of cytokines as a potential cause for AD susceptibility, we analyzed genotypes, allele distributions and haplotypes of IL-10 promoter polymorphisms -1082 (rs1800896) and -819 (rs1800871) in a Mexican population: 986 normal controls and 221 cases divided as follows: 122 with Alzheimer disease (AD), 67 with (VaD) and 32 with mixed dementia (AD/VaD). Patients with dementia showed increased frequency of "ATA, CTG, and CTA" haplotypes when compared to controls. We identified two risk haplotypes: ATA (OR=3.56, 95%CI=2.84-4.45, p<0.0001), and CTA (OR=1.90, 95%CI=1.38-2.62, p<0.0001), and four protection haplotypes: ATG (OR=0.60, 95%CI=0.45-0.82, p=0.0012), CTG (OR=0.38, 95%CI=0.23-0.62, p<0.0001), ACG (OR=0.01, 95%CI=0.002-1.13, p<0.0001), and CCG (OR=0.02, 95%CI=0.004-0.203, p<0.0001). In summary, this is the first study in Mexican population that considers the analysis of IL-10 in patients with AD, VaD and AD/VaD. Our results showed the relevance of the role that IL-10 plays in the pathological mechanisms that result in the development of dementia. In addition, in our study, it was possible to distinguish two protective and two risk haplotypes for the development of dementia.
authors.affiliation: Department of Molecular Biology, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, Mexico.
authors.forename: Gilberto
authors.initials: G
authors.lastname: Vargas-Alarcón
authors.affiliation: Department of Molecular Biology, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, Mexico.
authors.forename: Enrique
authors.initials: E
authors.lastname: Juárez-Cedillo
authors.affiliation: Community Health Research, Department, Hospital Infantil de Mexico Federico Gomez, Ministry of Health (SSA), Mexico City, Mexico.
authors.forename: Nancy
authors.initials: N
authors.lastname: Martínez-Rodríguez
authors.affiliation: Department of Molecular Biology, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, Mexico.
authors.forename: José Manuel
authors.initials: JM
authors.lastname: Fragoso
authors.affiliation: Medical Research Unit in Human Genetics, Pediatric Hospital, Mexican Institute of Social Security, Mexico City, Mexico.
authors.forename: Normand
authors.initials: N
authors.lastname: García-Hernández
authors.affiliation: Clinical Epidemiology Research Unit, Dr. Carlos McGregor Sánchez Regional General Hospital No. 1, Mexican Institute of Social Security, Mexico City, Mexico; Faculty of High Studies (FES) Zaragoza, National Autonomous University of Mexico, Mexico City, Mexico. Electronic address: terezillo@exalumno.unam.mx.
authors.forename: Teresa
authors.initials: T
authors.lastname: Juárez-Cedillo
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000235:genetics* / Q000276:immunology; D003704:Dementia / Q000235:genetics* / Q000276:immunology; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D016753:Interleukin-10 / Q000235:genetics*; D008297:Male; D008800:Mexico; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors
chemical_list: D016753:Interleukin-10
keywords: Alzheimer's disease; Dementia; Genetic association; Haplotypes; Interleukin; Polymorphisms