title: Twenty-four-hour intraocular pressure and ocular perfusion pressure characteristics in newly diagnosed patients with normal tension glaucoma.
abstract: PurposeTo determine the mean 24-h intraocular pressure (IOP) and mean ocular perfusion pressure (MOPP) characteristics of newly diagnosed, previously untreated, Caucasian, normal tension glaucoma (NTG) patients and to identify relationships between these features and visual field (VF) loss at diagnosis.MethodsConsecutive newly diagnosed NTG patients underwent 24-h habitual IOP and blood pressure (BP) monitoring. Parameters from pooled measurements obtained in the sitting (0800-2200 hours) and supine (1200-0600 hours) positions were compared and associations were sought with VF mean deviation (MD) and pattern standard deviation (PSD).ResultsSixty-two Caucasian NTG patients (24 men and 38 women) successfully completed circadian IOP and BP monitoring. In habitual position, 8 subjects (12.9%) exhibited a diurnal acrophase, 42 subjects (67.7%) demonstrated a nocturnal acrophase, one subject (1.6%) showed a flat rhythm and 11 patients (17.7%) revealed a biphasic/polyphasic rhythm. Nighttime MOPP values (supine position) were significantly greater than diurnal values (sitting position); (P<0.001). No association could be demonstrated between glaucomatous damage, as indicated by VF parameters, and either mean habitual 24-h IOP (P=0.20 and P=0.12 for MD and PSD, respectively), or habitual 24-h MOPP (P=0.96 and 0.29, for MD and PSD, respectively).ConclusionsIn this cohort of Caucasian NTG patients, most patients exhibited a nocturnal IOP acrophase when evaluated in a habitual position. No association was found between 24-h IOP or MOPP and VF damage.
authors.affiliation: Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, University of Brescia, Brescia, Italy.
authors.forename: L
authors.initials: L
authors.lastname: Quaranta
authors.affiliation: Ophthalmology Department, University of Ioannina, Ioannina, Greece.
authors.forename: A
authors.initials: A
authors.lastname: Katsanos
authors.affiliation: Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, University of Brescia, Brescia, Italy.
authors.forename: I
authors.initials: I
authors.lastname: Riva
authors.affiliation: Moorfields Eye Hospital, London, UK.
authors.forename: A
authors.initials: A
authors.lastname: Dastiridou
authors.affiliation: IRCCS Fondazione G.B. Bietti, Rome, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Oddone
authors.affiliation: IRCCS Fondazione G.B. Bietti, Rome, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Roberti
authors.affiliation: Glaucoma Unit, 1st University Department of Ophthalmology, AHEPA Hospital, Thessaloniki, Greece.
authors.forename: A G P
authors.initials: AG
authors.lastname: Konstas
mesh_terms: D000368:Aged; D001794:Blood Pressure / Q000502:physiology; D002940:Circadian Rhythm / Q000502:physiology*; D003430:Cross-Sectional Studies; D005123:Eye / Q000098:blood supply*; D005260:Female; D006068:Gonioscopy; D006801:Humans; D007429:Intraocular Pressure / Q000502:physiology*; D057066:Low Tension Glaucoma / Q000175:diagnosis / Q000208:ethnology / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D011187:Posture; D014065:Tonometry, Ocular; D014786:Vision Disorders / Q000175:diagnosis; D014794:Visual Fields / Q000502:physiology; D044465:White People / Q000208:ethnology