title: Personalizing Busulfan-Based Conditioning: Considerations from the American Society for Blood and Marrow Transplantation Practice Guidelines Committee.
abstract: The Practice Guidelines Committee of the American Society of Blood or Marrow Transplantation (ASBMT) sought to develop an evidence-based review about personalizing busulfan-based conditioning. The Committee sought to grade the relevant published studies (June 1, 2008 through March 31, 2016) according to criteria set forth by the Steering Committee for Evidence Based Reviews from ASBMT. Unfortunately, the published literature was too heterogeneous and lacked adequately powered and sufficiently controlled studies for this to be feasible. Despite this observation, the continued interest in this topic led the Practice Guidelines Committee to develop a list of most frequently asked questions (FAQs) regarding personalized busulfan dosing. This "Considerations" document is a list of these FAQs and their responses, addressing topics of practical relevance to hematopoietic cell transplantation clinicians.
authors.affiliation: Division of Hematology/Oncology, Mayo Clinic, Phoenix, Arizona. Electronic address: Palmer.Jeanne@mayo.edu.
authors.forename: Jeanne
authors.initials: J
authors.lastname: Palmer
authors.affiliation: Department of Pharmacology University of Washington, Fred Hutchinson Cancer Research Center, Seattle, Washington. Electronic address: jmccune@u.washington.edu.
authors.forename: Jeannine S
authors.initials: JS
authors.lastname: McCune
authors.affiliation: Division of Hematology/Oncology, Memorial Sloan Kettering Cancer Center, New York, New York.
authors.forename: Miguel-Angel
authors.initials: MA
authors.lastname: Perales
authors.affiliation: Pediatric Bone Marrow Transplant, University Hospitals Bristol NHS Trust, Bristol Royal Infirmary, Bristol, United Kingdom.
authors.forename: David
authors.initials: D
authors.lastname: Marks
authors.affiliation: Department of Pharmacy Practice, Oregon Health Sciences University, Portland, Oregon.
authors.forename: Joseph
authors.initials: J
authors.lastname: Bubalo
authors.affiliation: Department of Hematology, Hospital Saint-Antoine, University UPMC, Paris, France.
authors.forename: Mohamad
authors.initials: M
authors.lastname: Mohty
authors.affiliation: Division of Hematology/Oncology, University of Florida, Gainesville, Florida.
authors.forename: John R
authors.initials: JR
authors.lastname: Wingard
authors.affiliation: Pharmacology and Drug Analysis Department, Institut de Cancerologie Gustav Roussy, Villejuif, France.
authors.forename: Angelo
authors.initials: A
authors.lastname: Paci
authors.affiliation: Department of Clinical Research Centre, Karolinska Institutet, Stockholm, Sweden.
authors.forename: Moustapha
authors.initials: M
authors.lastname: Hassan
authors.affiliation: Hematology, Department of Medicine, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada.
authors.forename: Christopher
authors.initials: C
authors.lastname: Bredeson
authors.affiliation: Department of Blood and Marrow Transplantation, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida.
authors.forename: Joseph
authors.initials: J
authors.lastname: Pidala
authors.affiliation: Department of Stem Cell Transplantation and Cellular Therapy, MD Anderson Cancer Center, Houston, Texas.
authors.forename: Nina
authors.initials: N
authors.lastname: Shah
authors.affiliation: Adult Blood and Marrow Transplant, Texas Transplant Physician's Group, San Antonio, Texas.
authors.forename: Paul
authors.initials: P
authors.lastname: Shaughnessy
authors.affiliation: Department of Hematology and Medical Oncology, Cleveland Clinic, Cleveland, Ohio.
authors.forename: Navneet
authors.initials: N
authors.lastname: Majhail
authors.affiliation: Cancer Transplant Institute, Honor Health, Scottsdale, Arizona.
authors.forename: Jeff
authors.initials: J
authors.lastname: Schriber
authors.affiliation: Division of Hematology/Oncology, Vanderbuilt-Ingram Cancer Center, Nashville, Tennessee.
authors.forename: Bipin N
authors.initials: BN
authors.lastname: Savani
authors.affiliation: Department of Pediatrics, Fred Hutchinson Cancer Research Center, University of Washington, Seattle, Washington.
authors.forename: Paul A
authors.initials: PA
authors.lastname: Carpenter
mesh_terms: D002066:Busulfan / Q000008:administration & dosage*; D018380:Hematopoietic Stem Cell Transplantation / Q000379:methods; D006801:Humans; D019653:Myeloablative Agonists / Q000627:therapeutic use; D057285:Precision Medicine / Q000379:methods*; D019172:Transplantation Conditioning / Q000379:methods*
chemical_list: D019653:Myeloablative Agonists; D002066:Busulfan
keywords: Busulfan; Hematopoietic cell transplantation; Pharmacokinetics; Precision medicine; Therapeutic drug monitoring