title: [Retrospective study of Traditional Chinese Medicine treatment of type 2 diabetes mellitus].
abstract: OBJECTIVE
  To provide clinical evidence in support of Dahuang Huanglian Xiexin decoction (DHXD) to treat type 2 diabetes mellitus (T2DM) and to introduce a new treatment option for clinicians.
  
  
  METHODS
  Retrospective analysis was used to evaluate DHXD for the treatment of T2DM by analyzing clinical records of 183 cases. Patients with T2DM who met the inclusion criteria between January 1, 2013 and January 1, 2014 were enrolled. The effects of the treatment were evaluated by the changes in fasting blood-glucose (FBG), postprandial blood sugar (PBG), hemoglobin A1c (HbA1c), blood lipid profiles and body mass index (BMI) at 1, 2, 3 and 6 months. The changes in main symptoms were also evaluated. The dosage of Huanglian (Rhizoma Coptidis) and related factors were analyzed.
  
  
  RESULTS
  There was a significant improvement in mean HbA1C at 3 and 6 months after DHXD treatment compared with the baseline level (P < 0.01). There were also significant improvements in FBG, PBG, blood lipid series and BMI. DHXD also improved the main symptoms of stomach and intestine excessive heat syndrome in patients with obese T2DM. Huanglian (Rhizoma Coptidis) was the most frequently used in 678 clinical visits, the dosage of Huanglian (Rhizoma Coptidis) was related to age, BMI, DM duration, the level of blood glucose, and use of Western hypoglycemic drugs.
  
  
  CONCLUSIONS
  This study suggests that DHXD could decrease blood glucose and improve T2DM symptoms and reduce body weight. The use of DHXD may indicate a new optional treatment for T2DM.
authors.forename: Bing
authors.initials: B
authors.lastname: Pang
authors.forename: Jing
authors.initials: J
authors.lastname: Guo
authors.forename: Linhua
authors.initials: L
authors.lastname: Zhao
authors.forename: Xiyan
authors.initials: X
authors.lastname: Zhao
authors.forename: Qiang
authors.initials: Q
authors.lastname: Zhou
authors.forename: Xiaolin
authors.initials: X
authors.lastname: Tong
mesh_terms: D000328:Adult; D000368:Aged; D001786:Blood Glucose / Q000378:metabolism; D015992:Body Mass Index; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy* / Q000378:metabolism; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage*; D005260:Female; D006442:Glycated Hemoglobin / Q000378:metabolism; D006801:Humans; D007004:Hypoglycemic Agents / Q000008:administration & dosage*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D055815:Young Adult
chemical_list: D001786:Blood Glucose; D004365:Drugs, Chinese Herbal; D006442:Glycated Hemoglobin; D007004:Hypoglycemic Agents