title: Surgery for Benign Gynecological Disorders Improve Endometrium Receptivity.
abstract: Regardless of the anatomical locations, some benign gynecological disorders (BGDs) such as peritoneal endometriosis, ovarian endometrioma, adenomyosis, uterine leiomyomas, endometrial polyps, uterine septum, and hydrosalpinges may lead to implantation failure. Despite progress in medical therapies, surgery remains a mainstay of BGDs treatment. Although our knowledge of endometrial receptivity after BGDs surgery is limited, it has allowed for significant improvement in the treatment of female subfertility. Many researchers studied on pregnancy outcome following BGDs surgery, but they did not investigate the possible impact of surgery on endometrial receptivity. They, therefore, concluded that pregnancy rates improved after BGDs surgery based on clinical observations. Many of these clinicians believe that surgical resection of BGDs leads to removal of local mechanical effect over the endometrium. Moreover, they accept that BGDs surgery may inhibit the detrimental signaling and secretion of some molecules from the BGDSs into the endometrium that may lead to favorable effect on the endometrium. However, so far, data from randomized controlled trials or systematic review or meta-analyses to answer the question whether surgical treatment of BGDs can improve endometrial receptivity are lacking. The purpose of this systematic review was to evaluate the results of available publications dealing with the impact of reproductive surgery for BGDs on endometrial receptivity.
authors.affiliation: 1 Private Clinic, Obstetrics and Gynecology, Usak, Turkey.
authors.forename: Onder
authors.initials: O
authors.lastname: Celik
authors.affiliation: 2 Department of Obstetrics and Gynecology, Medipol University School of Medicine, Istanbul, Turkey.
authors.forename: Mustafa
authors.initials: M
authors.lastname: Acet
authors.affiliation: 3 Department of Obstetrics and Gynecology, Acıbadem University School of Medicine, Istanbul, Turkey.
authors.forename: Tansu
authors.initials: T
authors.lastname: Kucuk
authors.affiliation: 4 Obstetrics and Gynecology, Umraniye Education and Research Hospital, İstanbul, Turkey.
authors.forename: Esra Tustas
authors.initials: ET
authors.lastname: Haberal
authors.affiliation: 5 Obstetrics and Gynecology, Medicine Hospital, Istanbul, Turkey.
authors.forename: Tuba
authors.initials: T
authors.lastname: Acet
authors.affiliation: 6 Department of Obstetrics and Gynecology, Sakarya University School of Medicine, Sakarya, Turkey.
authors.forename: Murat
authors.initials: M
authors.lastname: Bozkurt
authors.affiliation: 7 Department of Obstetrics and Gynecology, Kafkas University School of Medicine, Kars, Turkey.
authors.forename: Levent
authors.initials: L
authors.lastname: Sahin
authors.affiliation: 8 Obstetrics and Gynecology, Süleymaniye Education and Research Hospital, İstanbul, Turkey.
authors.forename: Fatma Ferda
authors.initials: FF
authors.lastname: Verit
authors.affiliation: 9 Department of Obstetrics and Gynecology, Bahcesehir University School of Medicine, Kocaeli, Turkey.
authors.forename: Eray
authors.initials: E
authors.lastname: Caliskan
mesh_terms: D010064:Embryo Implantation / Q000502:physiology*; D004717:Endometrium / Q000502:physiology*; D005260:Female; D005831:Genital Diseases, Female / Q000601:surgery*; D006801:Humans; D011247:Pregnancy; D018873:Pregnancy Rate; D016896:Treatment Outcome
keywords: benign gynecological disorders; endometrium; receptivity; surgery