title: Transforming Growth Factor Beta 1 (TGF-β1) in Thyroid Cancer Patients: a View from the Peripheral Blood.
abstract: Transforming growth factor beta (TGF-β) plays an important role in many pathophysiological conditions, including cancer. The level of TGF-β in patients with differentiated thyroid cancer (DTC) has not been examined so far. The aim of this study was to measure TGF-β concentration in serum samples and in PHA-stimulated whole blood culture in vitro and to analyze possible associations of TGF-β1 levels with leukocyte, lymphocyte and platelets counts, the histological type of thyroid cancer, and stage of disease. TGF-β1 was measured in 22 DTC patients and 20 healthy controls using the duoSet ELISA Development kit for human TGF-β1. The concentration of TGF-β1 in serum samples from both groups correlated positively with the platelet counts. There was no statistically significant difference in the serum concentrations of TGF-β1 between DTC patients and control subjects, but PHA stimulated whole blood cultures of DTC patients produced less TGF-β1 than those from controls. Additional studies are needed to determine the significance of these in vitro findings.
authors.affiliation: Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia snezana@medf.kg.ac.rs.
authors.forename: Snezana
authors.initials: S
authors.lastname: Zivancevic-Simonovic
authors.affiliation: Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia.
authors.forename: Olgica
authors.initials: O
authors.lastname: Mihaljevic
authors.affiliation: Institute for Medical Research, Military Medical Academy, Belgrade, Serbia.
authors.forename: Dusan
authors.initials: D
authors.lastname: Mihajlovic
authors.affiliation: Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia.
authors.forename: Olivera
authors.initials: O
authors.lastname: Milosevic-Djordjevic
authors.affiliation: Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia.
authors.forename: Zorica
authors.initials: Z
authors.lastname: Jovanovic
authors.affiliation: Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia Clinical Center Kragujevac, Kragujevac, Serbia.
authors.forename: Ljiljana
authors.initials: L
authors.lastname: Mijatovic-Teodorovic
authors.affiliation: Institute for Medical Research, Military Medical Academy, Belgrade, Serbia.
authors.forename: Miodrag
authors.initials: M
authors.lastname: Colic
mesh_terms: D001772:Blood Cell Count; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D013964:Thyroid Neoplasms / Q000097:blood*; D053773:Transforming Growth Factor beta1 / Q000097:blood*
chemical_list: D053773:Transforming Growth Factor beta1