title: The pressing need for real-time risk assessment of hospital-acquired acute kidney injury.
abstract: Acute Kidney Injury (AKI) is associated with short- and long-term outcomes that reflect the severity of the injury. Recent studies have suggested that 'early' initiation of renal replacement therapy may alter the course of AKI and improve short-term outcomes like inpatient mortality. The current Kidney Disease Improving Global Outcomes (KDIGO) consensus definition of AKI has been criticized for misclassification bias, lack of sensitivity and the static manner in which AKI stages are defined. This editorial reviews various approaches to improving the specificity and sensitivity of the KDIGO AKI criteria, and also concludes that a staging system based on creatinine trajectories would be better suited for developing a prognostic index for real-time, dynamic risk assessment that the current KDIGO staging criteria.
authors.forename: David G
authors.initials: DG
authors.lastname: Warnock
mesh_terms: D058186:Acute Kidney Injury / Q000209:etiology* / Q000401:mortality / Q000503:physiopathology; D017052:Hospital Mortality; D006760:Hospitalization / Q000639:trends*; D006801:Humans; D020380:Needs Assessment; D018570:Risk Assessment; D013997:Time Factors
keywords: creatinine trajectory; multivariable regression models; prognostic index; serum creatinine