title: Light-controlled active release of photocaged ciprofloxacin for lipopolysaccharide-targeted drug delivery using dendrimer conjugates.
abstract: We report an active delivery mechanism targeted specifically to Gram(-) bacteria based on the photochemical release of photocaged ciprofloxacin carried by a cell wall-targeted dendrimer nanoconjugate.
authors.affiliation: Michigan Nanotechnology Institute for Medicine and Biological Sciences, University of Michigan, Ann Arbor, Michigan 48109, USA. ptw@umich.edu skchoi@umich.edu and Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan 48109, USA.
authors.forename: Pamela T
authors.initials: PT
authors.lastname: Wong
authors.affiliation: Michigan Nanotechnology Institute for Medicine and Biological Sciences, University of Michigan, Ann Arbor, Michigan 48109, USA. ptw@umich.edu skchoi@umich.edu and Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan 48109, USA.
authors.forename: Shengzhuang
authors.initials: S
authors.lastname: Tang
authors.affiliation: Michigan Nanotechnology Institute for Medicine and Biological Sciences, University of Michigan, Ann Arbor, Michigan 48109, USA. ptw@umich.edu skchoi@umich.edu and Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan 48109, USA.
authors.forename: Jhindan
authors.initials: J
authors.lastname: Mukherjee
authors.affiliation: Michigan Nanotechnology Institute for Medicine and Biological Sciences, University of Michigan, Ann Arbor, Michigan 48109, USA. ptw@umich.edu skchoi@umich.edu.
authors.forename: Kenny
authors.initials: K
authors.lastname: Tang
authors.affiliation: Michigan Nanotechnology Institute for Medicine and Biological Sciences, University of Michigan, Ann Arbor, Michigan 48109, USA. ptw@umich.edu skchoi@umich.edu.
authors.forename: Kristina
authors.initials: K
authors.lastname: Gam
authors.affiliation: Michigan Nanotechnology Institute for Medicine and Biological Sciences, University of Michigan, Ann Arbor, Michigan 48109, USA. ptw@umich.edu skchoi@umich.edu.
authors.forename: Danielle
authors.initials: D
authors.lastname: Isham
authors.affiliation: Michigan Nanotechnology Institute for Medicine and Biological Sciences, University of Michigan, Ann Arbor, Michigan 48109, USA. ptw@umich.edu skchoi@umich.edu.
authors.forename: Claire
authors.initials: C
authors.lastname: Murat
authors.affiliation: Michigan Nanotechnology Institute for Medicine and Biological Sciences, University of Michigan, Ann Arbor, Michigan 48109, USA. ptw@umich.edu skchoi@umich.edu.
authors.forename: Rachel
authors.initials: R
authors.lastname: Sun
authors.affiliation: Michigan Nanotechnology Institute for Medicine and Biological Sciences, University of Michigan, Ann Arbor, Michigan 48109, USA. ptw@umich.edu skchoi@umich.edu and Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan 48109, USA.
authors.forename: James R
authors.initials: JR
authors.lastname: Baker
authors.affiliation: Michigan Nanotechnology Institute for Medicine and Biological Sciences, University of Michigan, Ann Arbor, Michigan 48109, USA. ptw@umich.edu skchoi@umich.edu and Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan 48109, USA.
authors.forename: Seok Ki
authors.initials: SK
authors.lastname: Choi
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology* / Q000528:radiation effects; D002939:Ciprofloxacin / Q000737:chemistry / Q000494:pharmacology* / Q000528:radiation effects; D050091:Dendrimers / Q000138:chemical synthesis / Q000737:chemistry*; D016503:Drug Delivery Systems; D004926:Escherichia coli / Q000187:drug effects / Q000378:metabolism; D006090:Gram-Negative Bacteria / Q000187:drug effects* / Q000378:metabolism; D008024:Ligands; D008070:Lipopolysaccharides / Q000378:metabolism*; D058726:Nanoconjugates / Q000737:chemistry; D011073:Polyamines / Q000138:chemical synthesis / Q000737:chemistry; D011112:Polymyxin B / Q000737:chemistry; D014466:Ultraviolet Rays
chemical_list: D000900:Anti-Bacterial Agents; D050091:Dendrimers; D008024:Ligands; D008070:Lipopolysaccharides; D058726:Nanoconjugates; C531249:Poly(amidoamine); D011073:Polyamines; D002939:Ciprofloxacin; D011112:Polymyxin B