title: Chronic lymphocytic leukemia development is accelerated in mice with deficiency of the pro-apoptotic regulator NOXA.
authors.affiliation: Department of Hematology, Academic Medical Center, The Netherlands Department of Experimental Immunology, Academic Medical Center, The Netherlands.
authors.forename: Erik
authors.initials: E
authors.lastname: Slinger
authors.affiliation: Department of Experimental Immunology, Academic Medical Center, The Netherlands.
authors.forename: Felix M
authors.initials: FM
authors.lastname: Wensveen
authors.affiliation: Department of Pathology, Academic Medical Center, The Netherlands Lymphoma and Myeloma Center Amsterdam (LYMMCARE), The Netherlands.
authors.forename: Jeroen E
authors.initials: JE
authors.lastname: Guikema
authors.affiliation: Department of Hematology, Academic Medical Center, The Netherlands Lymphoma and Myeloma Center Amsterdam (LYMMCARE), The Netherlands.
authors.forename: Arnon P
authors.initials: AP
authors.lastname: Kater
authors.affiliation: Department of Experimental Immunology, Academic Medical Center, The Netherlands Lymphoma and Myeloma Center Amsterdam (LYMMCARE), The Netherlands e.eldering@amc.uva.nl.
authors.forename: Eric
authors.initials: E
authors.lastname: Eldering
mesh_terms: D000818:Animals; D051017:Apoptosis Regulatory Proteins / Q000502:physiology*; D018450:Disease Progression; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000473:pathology*; D051379:Mice; D018345:Mice, Knockout; D008822:Mice, Transgenic; D064549:Myeloid Cell Leukemia Sequence 1 Protein / Q000032:analysis; D011518:Proto-Oncogene Proteins / Q000032:analysis; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000172:deficiency* / Q000502:physiology; D011947:Receptors, Antigen, B-Cell
chemical_list: D051017:Apoptosis Regulatory Proteins; C579094:Mcl1 protein, mouse; D064549:Myeloid Cell Leukemia Sequence 1 Protein; C408009:Pmaip1 protein, mouse; D011518:Proto-Oncogene Proteins; D019253:Proto-Oncogene Proteins c-bcl-2; D011947:Receptors, Antigen, B-Cell; C490393:Tcl1 protein, mouse
keywords: NOXA; chronic lymphocytic leukemia; oncomodulator