title: Major neurotransmitter systems in dorsal hippocampus and basolateral amygdala control social recognition memory.
abstract: Social recognition memory (SRM) is crucial for reproduction, forming social groups, and species survival. Despite its importance, SRM is still relatively little studied. Here we examine the participation of the CA1 region of the dorsal hippocampus (CA1) and the basolateral amygdala (BLA) and that of dopaminergic, noradrenergic, and histaminergic systems in both structures in the consolidation of SRM. Male Wistar rats received intra-CA1 or intra-BLA infusions of different drugs immediately after the sample phase of a social discrimination task and 24-h later were subjected to a 5-min retention test. Animals treated with the protein synthesis inhibitor, anisomycin, into either the CA1 or BLA were unable to recognize the previously exposed juvenile (familiar) during the retention test. When infused into the CA1, the β-adrenoreceptor agonist, isoproterenol, the D1/D5 dopaminergic receptor antagonist, SCH23390, and the H2 histaminergic receptor antagonist, ranitidine, also hindered the recognition of the familiar juvenile 24-h later. The latter drug effects were more intense in the CA1 than in the BLA. When infused into the BLA, the β-adrenoreceptor antagonist, timolol, the D1/D5 dopamine receptor agonist, SKF38393, and the H2 histaminergic receptor agonist, ranitidine, also hindered recognition of the familiar juvenile 24-h later. In all cases, the impairment to recognize the familiar juvenile was abolished by the coinfusion of agonist plus antagonist. Clearly, both the CA1 and BLA, probably in that order, play major roles in the consolidation of SRM, but these roles are different in each structure vis-à-vis the involvement of the β-noradrenergic, D1/D5-dopaminergic, and H2-histaminergic receptors therein.
authors.affiliation: Memory Center, Brain Institute of Rio Grande do Sul, Pontifical Catholic University of Rio Grande do Sul, 90610-000 Porto Alegre, RS, Brazil;
authors.forename: Carolina
authors.initials: C
authors.lastname: Garrido Zinn
authors.affiliation: Département de Biologie, Ecole Normale Supérieure de Lyon, 69007 Lyon, France.
authors.forename: Nicolas
authors.initials: N
authors.lastname: Clairis
authors.affiliation: Memory Center, Brain Institute of Rio Grande do Sul, Pontifical Catholic University of Rio Grande do Sul, 90610-000 Porto Alegre, RS, Brazil;
authors.forename: Lorena Evelyn
authors.initials: LE
authors.lastname: Silva Cavalcante
authors.affiliation: Memory Center, Brain Institute of Rio Grande do Sul, Pontifical Catholic University of Rio Grande do Sul, 90610-000 Porto Alegre, RS, Brazil;
authors.forename: Cristiane Regina Guerino
authors.initials: CR
authors.lastname: Furini
authors.affiliation: Memory Center, Brain Institute of Rio Grande do Sul, Pontifical Catholic University of Rio Grande do Sul, 90610-000 Porto Alegre, RS, Brazil; jociane_carvalho@hotmail.com izquier@terra.com.br.
authors.forename: Jociane
authors.initials: J
authors.lastname: de Carvalho Myskiw
authors.affiliation: Memory Center, Brain Institute of Rio Grande do Sul, Pontifical Catholic University of Rio Grande do Sul, 90610-000 Porto Alegre, RS, Brazil; jociane_carvalho@hotmail.com izquier@terra.com.br.
authors.forename: Ivan
authors.initials: I
authors.lastname: Izquierdo
mesh_terms: D000679:Amygdala / Q000502:physiology*; D000818:Animals; D006624:Hippocampus / Q000502:physiology*; D008297:Male; D000069077:Memory Consolidation; D018377:Neurotransmitter Agents / Q000502:physiology*; D051381:Rats; D017208:Rats, Wistar; D011941:Receptors, Adrenergic / Q000502:physiology; D011954:Receptors, Dopamine / Q000502:physiology; D011970:Receptors, Histamine H2 / Q000502:physiology; D012919:Social Behavior
chemical_list: D018377:Neurotransmitter Agents; D011941:Receptors, Adrenergic; D011954:Receptors, Dopamine; D011970:Receptors, Histamine H2
keywords: basolateral amygdala; dopamine; hippocampus; norepinephrine; social memory