title: Analysis of Inflammatory Mediators in Prediabetes and Newly Diagnosed Type 2 Diabetes Patients.
abstract: This study evaluated the inflammatory markers in prediabetes and newly diagnosed type 2 diabetes mellitus (T2DM). Inflammatory markers levels were analyzed using one-way analysis of covariance and the association with prediabetes or T2DM risks was examined by logistic regression models. Our data showed increased levels of hypersensitivity C-reactive protein (hs-CRP), interleukin (IL-4), IL-10, and tryptase in prediabetes subjects and hs-CRP, immunoglobulin E (IgE), IL-4, and IL-10 in T2DM subjects. We concluded that Hs-CRP, IgE, IL-4, IL-10, and tryptase were positively associated with prediabetes or T2DM. Further large prospective studies are warranted to assess a temporal relation between inflammatory biomarkers and incidence of prediabetes or T2DM and its associated chronic diseases.
authors.affiliation: Department of Clinical Medicine, School of Nursing & Medicine, Huzhou University, Huzhou, Zhejiang 313000, China.
authors.forename: Zhen
authors.identifier: 0000-0003-4553-907X
authors.initials: Z
authors.lastname: Wang
authors.affiliation: Department of Nursing Medicine, School of Nursing & Medicine, Huzhou University, Huzhou, Zhejiang 313000, China.
authors.forename: Xu-Hui
authors.identifier: 0000-0003-3092-6667
authors.initials: XH
authors.lastname: Shen
authors.affiliation: Surgery Department, Huzhou Wu Xing People's Hospital, Huzhou, Zhejiang 313008, China.
authors.forename: Wen-Ming
authors.initials: WM
authors.lastname: Feng
authors.affiliation: Physical Examination Center, Zhebei Clinical Medicine Hospital, Huzhou University, Huzhou, Zhejiang 313000, China.
authors.forename: Guo-Fen
authors.identifier: 0000-0001-6015-0578
authors.initials: GF
authors.lastname: Ye
authors.affiliation: Endocrinology Department, Zhebei Clinical Medicine Hospital, Huzhou University, Huzhou, Zhejiang 313000, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Qiu
authors.affiliation: Huanzhu Street Community Health Center, Huzhou, Zhejiang 313000, China.
authors.forename: Bo
authors.identifier: 0000-0003-3547-5594
authors.initials: B
authors.lastname: Li
mesh_terms: D000368:Aged; D002097:C-Reactive Protein / Q000276:immunology; D016022:Case-Control Studies; D003924:Diabetes Mellitus, Type 2 / Q000276:immunology* / Q000378:metabolism; D005260:Female; D051858:Forkhead Transcription Factors / Q000378:metabolism; D006801:Humans; D007073:Immunoglobulin E / Q000276:immunology; D018836:Inflammation Mediators / Q000276:immunology* / Q000378:metabolism; D016753:Interleukin-10 / Q000276:immunology; D015847:Interleukin-4 / Q000276:immunology; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D011236:Prediabetic State / Q000276:immunology* / Q000378:metabolism; D053802:Tryptases / Q000276:immunology; D014409:Tumor Necrosis Factor-alpha / Q000276:immunology
chemical_list: C418974:FOXP3 protein, human; D051858:Forkhead Transcription Factors; C508609:IL10 protein, human; C508598:IL4 protein, human; D018836:Inflammation Mediators; C439524:TNF protein, human; D014409:Tumor Necrosis Factor-alpha; D016753:Interleukin-10; D015847:Interleukin-4; D007073:Immunoglobulin E; D002097:C-Reactive Protein; D053802:Tryptases