title: The Metabolic Role of Gut Microbiota in the Development of Nonalcoholic Fatty Liver Disease and Cardiovascular Disease.
abstract: The prevalence of metabolic disorders, such as type 2 diabetes (T2D), obesity, and non-alcoholic fatty liver disease (NAFLD), which are common risk factors for cardiovascular disease (CVD), has dramatically increased worldwide over the last decades. Although dietary habit is the main etiologic factor, there is an imperfect correlation between dietary habits and the development of metabolic disease. Recently, research has focused on the role of the microbiome in the development of these disorders. Indeed, gut microbiota is implicated in many metabolic functions and an altered gut microbiota is reported in metabolic disorders. Here we provide evidence linking gut microbiota and metabolic diseases, focusing on the pathogenetic mechanisms underlying this association.
authors.affiliation: Department of Clinical Medicine and Surgery, Gastroenterology Unit, Federico II University of Naples, 80131 Napoli, Italy. marcosanduzzizamparelli@yahoo.it.
authors.forename: Marco
authors.initials: M
authors.lastname: Sanduzzi Zamparelli
authors.affiliation: Department of Clinical Medicine and Surgery, Gastroenterology Unit, Federico II University of Naples, 80131 Napoli, Italy. comparedebora@libero.it.
authors.forename: Debora
authors.initials: D
authors.lastname: Compare
authors.affiliation: Department of Clinical Medicine and Surgery, Gastroenterology Unit, Federico II University of Naples, 80131 Napoli, Italy. pietro.coccoli@unina.it.
authors.forename: Pietro
authors.initials: P
authors.lastname: Coccoli
authors.affiliation: Department of Clinical Medicine and Surgery, Gastroenterology Unit, Federico II University of Naples, 80131 Napoli, Italy. a.rocco@unina.it.
authors.forename: Alba
authors.initials: A
authors.lastname: Rocco
authors.affiliation: Department of Clinical Medicine and Surgery, Gastroenterology Unit, Federico II University of Naples, 80131 Napoli, Italy. olga.nardone@libero.it.
authors.forename: Olga Maria
authors.initials: OM
authors.lastname: Nardone
authors.affiliation: Internal Medicine and Gastroenterology Area, Fondazione Policlinico Universitario A. Gemelli, Catholic University of Rome, 00168 Rome, Italy. giusmarrone@gmail.com.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Marrone
authors.affiliation: Internal Medicine and Gastroenterology Area, Fondazione Policlinico Universitario A. Gemelli, Catholic University of Rome, 00168 Rome, Italy. antonio.gasbarrini@unicatt.it.
authors.forename: Antonio
authors.initials: A
authors.lastname: Gasbarrini
authors.affiliation: Internal Medicine and Gastroenterology Area, Fondazione Policlinico Universitario A. Gemelli, Catholic University of Rome, 00168 Rome, Italy. antonio.grieco@unicatt.it.
authors.forename: Antonio
authors.initials: A
authors.lastname: Grieco
authors.affiliation: Internal Medicine and Gastroenterology Area, Fondazione Policlinico Universitario A. Gemelli, Catholic University of Rome, 00168 Rome, Italy. luca.miele@policlinicogemelli.it.
authors.forename: Gerardo
authors.initials: G
authors.lastname: Nardone
authors.affiliation: Internal Medicine and Gastroenterology Area, Fondazione Policlinico Universitario A. Gemelli, Catholic University of Rome, 00168 Rome, Italy. nardone@unina.it.
authors.forename: Luca
authors.initials: L
authors.lastname: Miele
mesh_terms: D001419:Bacteria / Q000378:metabolism*; D002318:Cardiovascular Diseases / Q000382:microbiology / Q000503:physiopathology*; D000069196:Gastrointestinal Microbiome; D006801:Humans; D065626:Non-alcoholic Fatty Liver Disease / Q000382:microbiology / Q000503:physiopathology*; D012307:Risk Factors
keywords: NAFLD; cardiovascular disease; gut microbiota