title: Myeloperoxidase Antineutrophil Cytoplasmic Antibody (MPO-ANCA) Associated Crescentic and Necrotizing Glomerulonephritis (GN) with Membranoproliferative GN Features.
abstract: A 77-year-old man presented with a fever, non-productive cough, and edema formation. A laboratory analysis showed an elevated creatinine level (2.5 mg/dL), a high titer of myeloperoxidase (MPO)-anti-neutrophil cytoplasmic antibody (ANCA) (99 U/mL), positive reaction for antinuclear antibody (×320), hematuria, and massive proteinuria (3.33 g/day). A renal biopsy revealed crescentic and necrotizing glomerulonephritis (GN) with membranoproliferative GN features [double contour appearance of the glomerular basement membrane, granular deposition of immunoglobulin (Ig) G, IgM, and C3 along the capillary wall, subendothelial and subepithelial deposits with mesangial interposition]. A potential relationship between MPO-ANCA associated GN and membranoproliferative GN is discussed.
authors.affiliation: Department of Nephrology, Dokkyo Medical University Koshigaya Hospital, Japan.
authors.forename: Ryo
authors.initials: R
authors.lastname: Koda
authors.forename: Katsuhiro
authors.initials: K
authors.lastname: Nagahori
authors.forename: Atsushi
authors.initials: A
authors.lastname: Kitazawa
authors.forename: Yuji
authors.initials: Y
authors.lastname: Imanishi
authors.forename: Atsunori
authors.initials: A
authors.lastname: Yoshino
authors.forename: Shinya
authors.initials: S
authors.lastname: Kawamoto
authors.forename: Yoshihiko
authors.initials: Y
authors.lastname: Ueda
authors.forename: Tetsuro
authors.initials: T
authors.lastname: Takeda
mesh_terms: D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000368:Aged; D019268:Antibodies, Antineutrophil Cytoplasmic / Q000032:analysis*; D005921:Glomerulonephritis / Q000188:drug therapy / Q000276:immunology* / Q000473:pathology*; D015432:Glomerulonephritis, Membranoproliferative / Q000188:drug therapy / Q000276:immunology* / Q000473:pathology*; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D008297:Male
chemical_list: D000305:Adrenal Cortex Hormones; D019268:Antibodies, Antineutrophil Cytoplasmic; D007166:Immunosuppressive Agents