title: Delivery of Nanoparticles for Treatment of Brain Tumor.
abstract: BACKGROUND
  Malignant brain tumor is a highly challenging disease for diagnosis, treatment, and management. Cytotoxicity, distribution and the ability to cross blood brain barrier are some of the most significant issues for the chemotherapy of brain tumors. Nanotechnology has been widely exploited in drug delivery with great potential in improving the drug efficiency and efficacy. The advent of nanotechnology would greatly facilitate the early detection and treatment of brain tumors. This review will be primarily focused on current nano drug delivery system for brain cancer therapy. Meanwhile, the existing impediments for therapeutic nanomedicines and critical analysis of the different delivery nanoparticles are also discussed.
  
  
  METHODS
  We systematically evaluated the major factors that impact the current nanomedicines for brain tumor therapy. Meanwhile, various nanoparticle-based formulations for brain cancer detection and therapy are evaluated.
  
  
  RESULTS
  124 papers were included in this review. From the analysis of the nanomaterials, seven major nanomaterials have been discussed regarding the functionality and current therapeutic significance. The review also explains in detail about the different types of nanomaterials and their functionalities. This shows that each of these nanomaterials has specialized functions for the treatment of various kinds of brain cancer.
  
  
  CONCLUSIONS
  Nanomaterials provide a viable potential diagnosis mechanis. In the future, more research needs to be focused on developing a better diagnosis tool for detection of cancer on an urgent basis. Blood-brain barrier and cytotoxicity are some of the primary root causes for the impediment of treatment of cancer using nanoparticles. Therefore, different delivery systems should be exploited for the nanoparticles to surmount these issues.
authors.forename: Chen
authors.initials: C
authors.lastname: Kang
authors.forename: Yuan
authors.initials: Y
authors.lastname: Sun
authors.forename: Jing
authors.initials: J
authors.lastname: Zhu
authors.forename: Wen
authors.initials: W
authors.lastname: Li
authors.forename: Aili
authors.initials: A
authors.lastname: Zhang
authors.forename: Tairong
authors.initials: T
authors.lastname: Kuang
authors.affiliation: Institute of Life Sciences, Jilin University, Changchun, Jilin, 130012 China. xiejing@jlu.edu.cn.
authors.forename: Jing
authors.initials: J
authors.lastname: Xie
authors.affiliation: Department of Chemical and Biomolecular Engineering, 481 CBEC, 151 W. Woodruff Ave, Columbus, OH, USA. yang.1140@osu.edu.
authors.forename: Zhaogang
authors.initials: Z
authors.lastname: Yang
mesh_terms: D000818:Animals; D001932:Brain Neoplasms / Q000188:drug therapy*; D016503:Drug Delivery Systems; D006801:Humans; D050997:Nanomedicine; D049329:Nanostructures / Q000008:administration & dosage* / Q000627:therapeutic use*