title: Chondroma arising from the spinal dura mater at the thoracic level: A case report with molecular analysis.
abstract: Chondromas are benign tumors that can be found at several sites in the body, while those arising from the dura mater are extremely rare. Among them, although chondromas arising from the cranial dura mater have been reported, those arising from the spinal dura mater have not been reported in the literature to date. A 66-year-old woman presented with right-sided continuous backache which she had developed recently. After detailed examinations, an epidural tumor at the thoracic level was detected. The patient underwent surgery and a total en-bloc resection was accomplished. From the clinical and pathological findings, the tumor was revealed as chondroma arising from the spinal dura mater. A recent comprehensive study has identified the isocitrate dehydrogenase 1 (IDH1) and IDH2 mutations in conventional central and periosteal cartilaginous tumors, and it has subsequently been analyzed in intracranial chondrosarcoma and chondroma, including chondroma of the convexity dura mater. Herein, we describe a novel case of chondroma arising from the spinal dura mater, with mutation analysis of IDH1 and IDH2 both of which revealed wild-type.
authors.affiliation: Department of Pathology, Nikko Memorial Hospital, Muroran, Hokkaido, Japan. Electronic address: masaya.myzk@gmail.com.
authors.forename: Masaya
authors.initials: M
authors.lastname: Miyazaki
authors.affiliation: Department of Orthopedic Surgery, Nikko Memorial Hospital, Muroran, Hokkaido, Japan.
authors.forename: Keita
authors.initials: K
authors.lastname: Yashiro
authors.affiliation: Department of Cancer Pathology, Hokkaido University Graduate School of Medicine, Sapporo, Hokkaido, Japan.
authors.forename: Mishie
authors.initials: M
authors.lastname: Tanino
authors.affiliation: Department of Cancer Pathology, Hokkaido University Graduate School of Medicine, Sapporo, Hokkaido, Japan.
authors.forename: Shinya
authors.initials: S
authors.lastname: Tanaka
authors.affiliation: Department of Pathology, Nikko Memorial Hospital, Muroran, Hokkaido, Japan; Department of Cancer Pathology, Hokkaido University Graduate School of Medicine, Sapporo, Hokkaido, Japan. Electronic address: yasunori.fujioka@nikko-kinen.or.jp.
authors.forename: Yasunori
authors.initials: Y
authors.lastname: Fujioka
mesh_terms: D000368:Aged; D002812:Chondroma / Q000235:genetics / Q000473:pathology* / Q000601:surgery; D004252:DNA Mutational Analysis; D004388:Dura Mater / Q000473:pathology* / Q000601:surgery; D005260:Female; D006801:Humans; D007521:Isocitrate Dehydrogenase / Q000235:genetics; D008577:Meningeal Neoplasms / Q000235:genetics / Q000473:pathology* / Q000601:surgery; D009154:Mutation; D013904:Thoracic Vertebrae; D016896:Treatment Outcome
chemical_list: C538784:IDH2 protein, human; D007521:Isocitrate Dehydrogenase; C543588:IDH1 protein, human
keywords: Chondroma; IDH1/2; Spinal dura mater