title: A new sesquiterpene lactone from yacon leaves.
abstract: The chemical constituents of 60% EtOH extract of yacon leaves were separated to yield a new compound, together with four known compounds, which were isolated for the first time from yacon. The new compound was characterised and named as chlorodalin (1) on the basis of NMR (1D and 2D), HR-MS and other spectral methods. The cytotoxic activities of 1-5 were evaluated on two human tumour cell lines and the new compound showed significant cytotoxic activity.
authors.affiliation: a College of Pharmacy , Liaoning University of Traditional Chinese Medicine , Dalian , PR China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Yuan
authors.affiliation: a College of Pharmacy , Liaoning University of Traditional Chinese Medicine , Dalian , PR China.|c Pharmaceutical Research Department , Ministry of Science and Technology , Yangon , Myanmar.
authors.forename: Khin Khin
authors.initials: KK
authors.lastname: Win Aung
authors.affiliation: a College of Pharmacy , Liaoning University of Traditional Chinese Medicine , Dalian , PR China.
authors.forename: Xiao-Ku
authors.initials: XK
authors.lastname: Ran
authors.affiliation: a College of Pharmacy , Liaoning University of Traditional Chinese Medicine , Dalian , PR China.
authors.forename: Xiao-Tong
authors.initials: XT
authors.lastname: Wang
authors.affiliation: a College of Pharmacy , Liaoning University of Traditional Chinese Medicine , Dalian , PR China.
authors.forename: De-Qiang
authors.initials: DQ
authors.lastname: Dou
authors.affiliation: b Technology Development Department , Zhen-Ao Co.Ltd , Dalian , PR China.
authors.forename: Feng
authors.initials: F
authors.lastname: Dong
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology; D019659:Asteraceae / Q000737:chemistry*; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D007783:Lactones / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology; D018515:Plant Leaves / Q000737:chemistry*; D012717:Sesquiterpenes / Q000737:chemistry*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D007783:Lactones; D010936:Plant Extracts; D012717:Sesquiterpenes
keywords: Smallanthus sonchifolius; chemical constituent; cytotoxic activity; sesquiterpene lactone; yacon