title: Synthesis of surfactant-free hydroxypropyl methylcellulose nanogels for controlled release of insulin.
abstract: A facile controlled-release nanogels delivery system has been developed by using hydroxypropyl methylcellulose (HPMC) hybrid nanogels as encapsulation shell materials, which were synthesized by surfactant-free polymerization in aqueous solution. The effects of reaction time and cross-linker concentration on the size of the nanogels have been studied. The results showed that in a certain range, the particle size decreased with increasing reaction time and increasing concentration of cross-linker. Meanwhile, at the feeding ratio 0.05/1 of HPMC/methacrylic acid (MAA), the LCST of prepared nanogels at pH=6 was close to the body temperature, which can be used as sustained insulin delivery system. Besides, the HPMC nanogels loaded with insulin had a high drug loading of 21.3% and a high entrapment efficiency of 95.7%. The release behavior of the insulin nanogels can be adjusted by pH and temperature which will have potential applications in controlled release delivery system.
authors.affiliation: College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai 201620, PR China.
authors.forename: Di
authors.initials: D
authors.lastname: Zhao
authors.affiliation: College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai 201620, PR China.
authors.forename: Xiaodi
authors.initials: X
authors.lastname: Shi
authors.affiliation: College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai 201620, PR China.
authors.forename: Tianqun
authors.initials: T
authors.lastname: Liu
authors.affiliation: College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai 201620, PR China; State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Materials Science and Engineering, Donghua University, Shanghai 201620, PR China. Electronic address: luxihua@dhu.edu.cn.
authors.forename: Xihua
authors.initials: X
authors.lastname: Lu
authors.affiliation: State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Materials Science and Engineering, Donghua University, Shanghai 201620, PR China.
authors.forename: Gao
authors.initials: G
authors.lastname: Qiu
authors.affiliation: Department of Chemistry, University of California, Irvine, CA 92697, USA. Electronic address: kjshea@uci.edu.
authors.forename: Kenneth J
authors.initials: KJ
authors.lastname: Shea
mesh_terms: D060326:Chemistry Techniques, Synthetic; D003692:Delayed-Action Preparations; D004337:Drug Carriers / Q000138:chemical synthesis* / Q000737:chemistry*; D065546:Drug Liberation; D005782:Gels; D006863:Hydrogen-Ion Concentration; D065347:Hypromellose Derivatives / Q000138:chemical synthesis* / Q000737:chemistry*; D007328:Insulin / Q000008:administration & dosage / Q000737:chemistry*; D007700:Kinetics; D008689:Methacrylates / Q000737:chemistry; D049329:Nanostructures / Q000737:chemistry*; D013696:Temperature
chemical_list: D003692:Delayed-Action Preparations; D004337:Drug Carriers; D005782:Gels; D007328:Insulin; D008689:Methacrylates; C008384:methacrylic acid; D065347:Hypromellose Derivatives
keywords: Controlled release; Nanogels; Surfactant-free; Temperature sensitivity; pH sensitivity