title: Modeling Leukemogenesis in the Zebrafish Using Genetic and Xenograft Models.
abstract: The zebrafish is a widely accepted model to study leukemia. The major advantage of studying leukemogenesis in zebrafish is attributed to its short life cycle and superior imaging capacity. This chapter highlights using transgenic- and xenograft-based models in zebrafish to study a specific leukemogenic mutation and analyze therapeutic responses in vivo.
authors.affiliation: Department of Microbiology and Immunology, Dalhousie University, Halifax, Canada, B3H 4R2.
authors.forename: Vinothkumar
authors.initials: V
authors.lastname: Rajan
authors.affiliation: Department of Pathology, Dalhousie University, 5850/5980 University Ave, Halifax, Canada, B3H 4R2.|Department of Biochemistry & Molecular Biology, Dalhousie University, Halifax, Canada, B3H 4R2.
authors.forename: Graham
authors.initials: G
authors.lastname: Dellaire
authors.affiliation: Department of Microbiology and Immunology, Dalhousie University, Halifax, Canada, B3H 4R2. Jason.Berman@iwk.nshealth.ca.|Department of Pathology, Dalhousie University, 5850/5980 University Ave, Halifax, Canada, B3H 4R2. Jason.Berman@iwk.nshealth.ca.|Department of Pediatrics, IWK Health Centre/Dalhousie University, Halifax, Canada, B3H 4R2. Jason.Berman@iwk.nshealth.ca.
authors.forename: Jason N
authors.initials: JN
authors.lastname: Berman
mesh_terms: D000818:Animals; D030801:Animals, Genetically Modified / Q000235:genetics / Q000378:metabolism* / Q000502:physiology*; D063646:Carcinogenesis / Q000378:metabolism / Q000473:pathology; D004195:Disease Models, Animal; D064593:Heterografts / Q000378:metabolism / Q000473:pathology; D006801:Humans; D007938:Leukemia / Q000378:metabolism* / Q000473:pathology*; D009154:Mutation / Q000235:genetics; D015027:Zebrafish / Q000235:genetics / Q000378:metabolism* / Q000502:physiology*
keywords: Meganuclease; Patient-derived xenograft; Transgenesis; Xenograft