title: Optic Disc Metastasis as the Presenting Sign of Lung Adenocarcinoma.
abstract: A 67-year-old woman noticed vision loss in her right eye and was found to have an elevated, well-circumscribed white mass within the right optic disc. The patient underwent an evaluation which revealed 4 brain metastases and a large left hilar mass that proved to be adenocarcinoma of the lung. Because she continued to lose vision, the optic disc metastasis was treated with stereotactic radiotherapy. Although she reported vision improvement, she died soon afterward. There are 9 previous reports in the English literature of isolated optic disc metastasis as the presenting sign of cancer. Familiarity with the features of optic disc metastasis can lead to earlier recognition and treatment of the underlying malignant neoplasm.
authors.affiliation: Department of Ophthalmology and Vision Science, University of Toronto, Toronto, Ontario, Canada.
authors.forename: Jonathan A
authors.initials: JA
authors.lastname: Micieli
authors.forename: Edward A
authors.initials: EA
authors.lastname: Margolin
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology*; D000077192:Adenocarcinoma of Lung; D000368:Aged; D001706:Biopsy; D003131:Combined Modality Therapy; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000473:pathology*; D008279:Magnetic Resonance Imaging; D009362:Neoplasm Metastasis; D009898:Optic Disk / Q000473:pathology*; D019574:Optic Nerve Neoplasms / Q000175:diagnosis / Q000556:secondary* / Q000628:therapy