title: Oxaliplatin-induced acute thrombocytopenia.
abstract: Oxaliplatin (1, 2-diamminocyclohexaneoxalato-platinum) is a novel platin analog, which is widely used in gastrointestinal malignancies. Platinum analogs damage cellular deoxyribonucleic acid (DNA) by leading covalent bifunctional DNA adducts with cellular DNA. Major side effects of oxaliplatin are neurotoxicity (peripheral neuropathy), myelosuppression with moderate thrombocytopenia and gastrointestinal toxicity (diarrhea). Thrombocytopenia might be related to myelosuppression and/or drug-induced immune thrombocytopenia (DIIT). In here, oxaliplatin-induced thrombocytopenia is discussed with review of the literature.
authors.affiliation: Department of Medical Oncology, Ankara Numune Training and Research Hospital, Altındağ/Ankara, Turkey.
authors.forename: Gokmen Umut
authors.initials: GU
authors.lastname: Erdem
authors.affiliation: Department of Medical Oncology, Ankara Numune Training and Research Hospital, Altındağ/Ankara, Turkey.
authors.forename: Mutlu
authors.initials: M
authors.lastname: Dogan
authors.affiliation: Department of Medical Oncology, Ankara Numune Training and Research Hospital, Altındağ/Ankara, Turkey.
authors.forename: Nebi Serkan
authors.initials: NS
authors.lastname: Demirci
authors.affiliation: Department of Medical Oncology, Ankara Numune Training and Research Hospital, Altındağ/Ankara, Turkey.
authors.forename: Nurullah
authors.initials: N
authors.lastname: Zengin
mesh_terms: D000970:Antineoplastic Agents / Q000009:adverse effects*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects; D005770:Gastrointestinal Neoplasms / Q000150:complications / Q000188:drug therapy; D006801:Humans; D009944:Organoplatinum Compounds / Q000009:adverse effects*; D000077150:Oxaliplatin; D013921:Thrombocytopenia / Q000175:diagnosis / Q000209:etiology* / Q000628:therapy
chemical_list: D000970:Antineoplastic Agents; D009944:Organoplatinum Compounds; D000077150:Oxaliplatin