title: Label-free optical quantification of structural alterations in Alzheimer's disease.
abstract: We present a wide-field quantitative label-free imaging of mouse brain tissue slices with sub-micrometre resolution, employing holographic microscopy and an automated scanning platform. From the measured light field images, scattering coefficients and anisotropies are quantitatively retrieved by using the modified the scattering-phase theorem, which enables access to structural information about brain tissues. As a proof of principle, we demonstrate that these scattering parameters enable us to quantitatively address structural alteration in the brain tissues of mice with Alzheimer's disease.
authors.affiliation: Department of Physics, Korea Advanced Institute of Science and Technology, Daejeon, 34141 South Korea.|KI for Health Science and Technology, Korea Advanced Institute of Science and Technology, Daejeon 34141, Republic of Korea.
authors.forename: Moosung
authors.initials: M
authors.lastname: Lee
authors.affiliation: KI for Health Science and Technology, Korea Advanced Institute of Science and Technology, Daejeon 34141, Republic of Korea.|Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology, Daejeon 34141, South Korea.|Department of Bio and Brain Engineering, Korea Advanced Institute of Science and Technology, Daejeon 34141, South Korea.
authors.forename: Eeksung
authors.initials: E
authors.lastname: Lee
authors.affiliation: Department of Physics, Korea Advanced Institute of Science and Technology, Daejeon, 34141 South Korea.|KI for Health Science and Technology, Korea Advanced Institute of Science and Technology, Daejeon 34141, Republic of Korea.
authors.forename: JaeHwang
authors.initials: J
authors.lastname: Jung
authors.affiliation: Department of Physics, Korea Advanced Institute of Science and Technology, Daejeon, 34141 South Korea.|KI for Health Science and Technology, Korea Advanced Institute of Science and Technology, Daejeon 34141, Republic of Korea.
authors.forename: Hyeonseung
authors.initials: H
authors.lastname: Yu
authors.affiliation: Department of Physics, Korea Advanced Institute of Science and Technology, Daejeon, 34141 South Korea.|KI for Health Science and Technology, Korea Advanced Institute of Science and Technology, Daejeon 34141, Republic of Korea.
authors.forename: Kyoohyun
authors.initials: K
authors.lastname: Kim
authors.affiliation: Department of Physics, Korea Advanced Institute of Science and Technology, Daejeon, 34141 South Korea.|KI for Health Science and Technology, Korea Advanced Institute of Science and Technology, Daejeon 34141, Republic of Korea.
authors.forename: Jonghee
authors.initials: J
authors.lastname: Yoon
authors.affiliation: KI for Health Science and Technology, Korea Advanced Institute of Science and Technology, Daejeon 34141, Republic of Korea.|Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon 34141, South Korea.
authors.forename: Shinhwa
authors.initials: S
authors.lastname: Lee
authors.affiliation: KI for Health Science and Technology, Korea Advanced Institute of Science and Technology, Daejeon 34141, Republic of Korea.|Department of Bio and Brain Engineering, Korea Advanced Institute of Science and Technology, Daejeon 34141, South Korea.
authors.forename: Yong
authors.initials: Y
authors.lastname: Jeong
authors.affiliation: Department of Physics, Korea Advanced Institute of Science and Technology, Daejeon, 34141 South Korea.|KI for Health Science and Technology, Korea Advanced Institute of Science and Technology, Daejeon 34141, Republic of Korea.|TOMOCUBE, Inc., Daejeon 34051, Republic of Korea.
authors.forename: YongKeun
authors.initials: Y
authors.lastname: Park
mesh_terms: D000544:Alzheimer Disease / Q000000981:diagnostic imaging* / Q000235:genetics / Q000378:metabolism*; D000818:Animals; D001921:Brain / Q000000981:diagnostic imaging* / Q000378:metabolism*; D008297:Male; D051379:Mice; D008822:Mice, Transgenic