title: Transversus abdominis plane block after laparoscopic colonic resection in cancer patients: A randomised clinical trial.
abstract: A key point in pathways for optimal rehabilitation and enhanced recovery is an effective postoperative multimodal pain treatment regimen.
  
  
  
  To investigate the analgesic effects of transversus abdominis plane (TAP) block in conjunction with paracetamol and ibuprofen in patients undergoing laparoscopic colonic resection.
  
  
  
  Randomised placebo-controlled double-blind study.
  
  
  
  Herlev University Hospital, Copenhagen, Denmark, from March 2010 to February 2013.
  
  
  
  Eighty adult patients scheduled for elective laparoscopic colectomy.
  
  
  
  Bilateral TAP block with 20 ml of either ropivacaine or isotonic saline.
  
  
  
  Visual analogue scale (VAS) pain scores (0 to 100 mm) while coughing at 6 h after surgery (primary outcome). Secondary outcomes were area under the curve pain scores (2 to 24 h) at rest and while coughing, 24-h morphine consumption and incidence of nausea and vomiting.
  
  
  
  VAS pain scores at 6 h while coughing was not different between groups (median, interquartile range), TAP, 27 (11 to 45) mm vs. placebo, 33 (20 to 49) mm (P = 0.20). Total 24-h morphine consumption was reduced in the TAP block group vs. placebo group, 30 (15 to 41) mg vs. 43 (30 to 67) mg, respectively (P = 0.008). This difference was most pronounced in the first postoperative hours. The remaining outcomes did not differ between groups.
  
  
  
  TAP block used in combination with paracetamol and ibuprofen did not reduce pain after laparoscopic colonic surgery. However, we found a 30% reduction in opioid use, most marked in the early postoperative period.
  
  
  
  www.clinicaltrials.gov (NCT01418144).
authors.affiliation: From the Department of Anaesthesiology (HT, EGH, MB, AUM, AMM), the Department of Surgery, Herlev Hospital (JR), the Department of Anaesthesiology, Rigshospitalet (PLP), the Department of Anaesthesiology, Køge Hospital (OM), the Department of Anaesthesiology, Bispebjerg Hospital, University of Copenhagen, Copenhagen, Denmark (JBD).
authors.forename: Henrik
authors.initials: H
authors.lastname: Torup
authors.forename: Egon G
authors.initials: EG
authors.lastname: Hansen
authors.forename: Mikkel
authors.initials: M
authors.lastname: Bøgeskov
authors.forename: Jacob
authors.initials: J
authors.lastname: Rosenberg
authors.forename: Anja U
authors.initials: AU
authors.lastname: Mitchell
authors.forename: Pernille L
authors.initials: PL
authors.lastname: Petersen
authors.forename: Ole
authors.initials: O
authors.lastname: Mathiesen
authors.forename: Jørgen B
authors.initials: JB
authors.lastname: Dahl
authors.forename: Ann M
authors.initials: AM
authors.lastname: Møller
mesh_terms: D000009:Abdominal Muscles / Q000601:surgery*; D000082:Acetaminophen / Q000008:administration & dosage; D000368:Aged; D003082:Colectomy / Q000009:adverse effects* / Q000639:trends; D003110:Colonic Neoplasms / Q000188:drug therapy / Q000453:epidemiology / Q000601:surgery*; D003718:Denmark / Q000453:epidemiology; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007052:Ibuprofen / Q000008:administration & dosage; D010535:Laparoscopy / Q000009:adverse effects* / Q000639:trends; D008297:Male; D008875:Middle Aged; D009407:Nerve Block / Q000379:methods* / Q000639:trends; D010149:Postoperative Pain / Q000175:diagnosis / Q000453:epidemiology / Q000517:prevention & control*
chemical_list: D000082:Acetaminophen; D007052:Ibuprofen