title: Serum Response Factor in Muscle Tissues: From Development to Ageing.
abstract: Skeletal, cardiac and smooth muscle cells share various common characteristic features. During development the embryonic mesodermal layer contribute at different proportions to the formation of these tissues. At the functional level, contractility as well as its decline during ageing, are also common features. Cytoskeletal components of these tissues are characterized by various actin isoforms that govern through their status (polymerised versus monomeric) and their interaction with the myosins the contractile properties of these muscles. Finally, at the molecular level, a set of different transcription factors with the notable exception of Serum Response Factor SRF- which is commonly enriched in the 3 types of muscle- drive and maintain the differentiation of these cells (Myf5, MyoD, Myogenin for skeletal muscle; Nkx2.5, GATA4 for cardiomyocytes). In this review, we will focus on the transcription factor SRF and its role in the homeostasis of cardiac, smooth and skeletal muscle tissues as well as its behaviour during the age related remodelling process of these tissues with a specific emphasis on animal models and human data when available.
authors.affiliation: Sorbonne University, UPMC, Department of Biological Adaptation and Ageing, IBPS, UMR 8256 CNRS, INSERM U1164, Paris, France; Dept of Anatomy, Histology, Forensic Medicine & Ortopedics, School of Medicine Sapienza University of Rome, Italy.
authors.forename: Dario
authors.initials: D
authors.lastname: Coletti
authors.affiliation: Sorbonne University, UPMC , Department of Biological Adaptation and Ageing, IBPS, UMR 8256 CNRS, INSERM U1164, Paris, France.
authors.forename: Nissrine
authors.initials: N
authors.lastname: Daou
authors.affiliation: Sorbonne University, UPMC , Department of Biological Adaptation and Ageing, IBPS, UMR 8256 CNRS, INSERM U1164, Paris, France.
authors.forename: Medhi
authors.initials: M
authors.lastname: Hassani
authors.affiliation: Sorbonne University, UPMC , Department of Biological Adaptation and Ageing, IBPS, UMR 8256 CNRS, INSERM U1164, Paris, France.
authors.forename: Zhenlin
authors.initials: Z
authors.lastname: Li
authors.affiliation: Sorbonne University, UPMC , Department of Biological Adaptation and Ageing, IBPS, UMR 8256 CNRS, INSERM U1164, Paris, France.
authors.forename: Ara
authors.initials: A
authors.lastname: Parlakian
keywords: Ageing; Cre/loxP; Muscle remodelling; Muscle tissue; SRF