title: The predictive factors for remission of chronic spontaneous urticaria in childhood: Outcome from a prospective study.
abstract: BACKGROUND
  There are few studies in children on the natural course of chronic spontaneous urticaria (CSU) because of its relative infrequency in childhood.
  
  
  OBJECTIVE
  To estimate the rate of remission and evaluate the prognostic factors in children with CSU.
  
  
  METHODS
  A total of 52 children with CSU were prospectively followed over a period of three years.
  
  
  RESULTS
  The remission rates at 12 months and 36 months were 32.7% and 48.1%. The mean duration of disease at the first visit in the non-remission group was higher than in the remission group at the end of the study (P=0.016). The remission rate of the patients who had been treated by standard dose antihistamine was higher than that of the patients who had been treated with the high-dose antihistamine and combination medications (P=0.004, P<0.001). The treatment steps were independent prognostic factors for remission by logistic regression analysis.
  
  
  CONCLUSIONS
  Our study indicates that urticaria controlled by a standard dose of antihistamine can predict a good prognosis independently from disease duration at first visit.
authors.affiliation: Division of Pediatric Allergy and Immunology, Kocaeli University, 41380 Umuttepe, Kocaeli, Turkey. Electronic address: dreserisil@hotmail.com.
authors.forename: I
authors.initials: I
authors.lastname: Eser
authors.affiliation: Division of Pediatric Allergy and Immunology, Kocaeli University, 41380 Umuttepe, Kocaeli, Turkey.
authors.forename: N
authors.initials: N
authors.lastname: Yologlu
authors.affiliation: Department of Biostatistics and Medical Informatics, Kocaeli University, Kocaeli, Turkey.
authors.forename: C
authors.initials: C
authors.lastname: Baydemir
authors.affiliation: Division of Pediatric Allergy and Immunology, Kocaeli University, 41380 Umuttepe, Kocaeli, Turkey.
authors.forename: M
authors.initials: M
authors.lastname: Aydogan
mesh_terms: D002648:Child; D002675:Child, Preschool; D002908:Chronic Disease; D005260:Female; D005500:Follow-Up Studies; D006633:Histamine Antagonists / Q000627:therapeutic use*; D006801:Humans; D007223:Infant; D008297:Male; D011379:Prognosis; D011446:Prospective Studies; D012074:Remission Induction; D012075:Remission, Spontaneous; D012307:Risk Factors; D014581:Urticaria / Q000175:diagnosis* / Q000188:drug therapy
chemical_list: D006633:Histamine Antagonists
keywords: Chronic urticaria; Predictive factors; Remission