title: ATM mutations in major stereotyped subsets of chronic lymphocytic leukemia: enrichment in subset #2 is associated with markedly short telomeres.
authors.affiliation: Department of Internal Medicine - Hematology and Oncology, University Hospital Brno and Faculty of Medicine, Masaryk University, Brno, Czech Republic Department of Molecular Medicine, CEITEC - Central European Institute of Technology, Masaryk University, Brno, Czech Republic Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala University, Sweden.
authors.forename: Veronika
authors.initials: V
authors.lastname: Navrkalova
authors.affiliation: Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala University, Sweden.
authors.forename: Emma
authors.initials: E
authors.lastname: Young
authors.affiliation: Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala University, Sweden.
authors.forename: Panagiotis
authors.initials: P
authors.lastname: Baliakas
authors.affiliation: Department of Molecular Medicine, CEITEC - Central European Institute of Technology, Masaryk University, Brno, Czech Republic.
authors.forename: Lenka
authors.initials: L
authors.lastname: Radova
authors.affiliation: Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala University, Sweden.
authors.forename: Lesley-Ann
authors.initials: LA
authors.lastname: Sutton
authors.affiliation: Department of Internal Medicine - Hematology and Oncology, University Hospital Brno and Faculty of Medicine, Masaryk University, Brno, Czech Republic Department of Molecular Medicine, CEITEC - Central European Institute of Technology, Masaryk University, Brno, Czech Republic.
authors.forename: Karla
authors.initials: K
authors.lastname: Plevova
authors.affiliation: Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala University, Sweden.
authors.forename: Larry
authors.initials: L
authors.lastname: Mansouri
authors.affiliation: Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala University, Sweden.
authors.forename: Viktor
authors.initials: V
authors.lastname: Ljungström
authors.affiliation: Institute of Applied Biosciences, CERTH, Thessaloniki, Greece.
authors.forename: Stavroula
authors.initials: S
authors.lastname: Ntoufa
authors.affiliation: Department of Molecular Pathology, Royal Bournemouth Hospital, UK.
authors.forename: Zadie
authors.initials: Z
authors.lastname: Davis
authors.affiliation: Department of Laboratory Medicine, Stem Cell Center, Hematology and Transplantation, Lund University, Sweden.
authors.forename: Gunnar
authors.initials: G
authors.lastname: Juliusson
authors.affiliation: Department of Medicine Solna, Clinical Epidemiology Unit, Karolinska Institutet, Stockholm, Sweden.
authors.forename: Karin E
authors.initials: KE
authors.lastname: Smedby
authors.affiliation: Hematology Department, General Hospital of Nikea, Piraeus, Greece.
authors.forename: Chrysoula
authors.initials: C
authors.lastname: Belessi
authors.affiliation: First Department of Propaedeutic Medicine, School of Medicine, University of Athens, Greece.
authors.forename: Panagiotis
authors.initials: P
authors.lastname: Panagiotidis
authors.affiliation: Institute of Applied Biosciences, CERTH, Thessaloniki, Greece Hematology Department and HCT Unit, G. Papanicolaou Hospital, Thessaloniki, Greece.
authors.forename: Tasoula
authors.initials: T
authors.lastname: Touloumenidou
authors.affiliation: Laboratory of Hematology, Hospital Pitie-Salpetriere and University Pierre and Marie Curie, Paris, France.
authors.forename: Frederic
authors.initials: F
authors.lastname: Davi
authors.affiliation: Department of Immunology, Erasmus MC, University Medical Center Rotterdam, the Netherlands.
authors.forename: Anton W
authors.initials: AW
authors.lastname: Langerak
authors.affiliation: Division of Experimental Oncology and Department of Onco-Hematology, IRCCS San Raffaele Scientific Institute, Milan, Italy.
authors.forename: Paolo
authors.initials: P
authors.lastname: Ghia
authors.affiliation: Cancer Sciences, Faculty of Medicine, University of Southampton, UK.
authors.forename: Jonathan C
authors.initials: JC
authors.lastname: Strefford
authors.affiliation: Department of Molecular Pathology, Royal Bournemouth Hospital, UK.
authors.forename: David
authors.initials: D
authors.lastname: Oscier
authors.affiliation: Department of Internal Medicine - Hematology and Oncology, University Hospital Brno and Faculty of Medicine, Masaryk University, Brno, Czech Republic.
authors.forename: Jiri
authors.initials: J
authors.lastname: Mayer
authors.affiliation: Institute of Applied Biosciences, CERTH, Thessaloniki, Greece.
authors.forename: Kostas
authors.initials: K
authors.lastname: Stamatopoulos
authors.affiliation: Department of Internal Medicine - Hematology and Oncology, University Hospital Brno and Faculty of Medicine, Masaryk University, Brno, Czech Republic Department of Molecular Medicine, CEITEC - Central European Institute of Technology, Masaryk University, Brno, Czech Republic.
authors.forename: Sarka
authors.initials: S
authors.lastname: Pospisilova
authors.affiliation: Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala University, Sweden.
authors.forename: Richard
authors.initials: R
authors.lastname: Rosenquist
authors.affiliation: Department of Internal Medicine - Hematology and Oncology, University Hospital Brno and Faculty of Medicine, Masaryk University, Brno, Czech Republic m.trbusek@volny.cz.
authors.forename: Martin
authors.initials: M
authors.lastname: Trbusek
mesh_terms: D064007:Ataxia Telangiectasia Mutated Proteins / Q000235:genetics*; D015331:Cohort Studies; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000145:classification* / Q000235:genetics / Q000401:mortality; D009154:Mutation; D017422:Sequence Analysis, DNA; D016019:Survival Analysis; D016615:Telomere / Q000648:ultrastructure; D059506:Telomere Shortening
chemical_list: C576324:ATM protein, human; D064007:Ataxia Telangiectasia Mutated Proteins
keywords: ATM mutation; antigenic selection; chronic lymphocytic leukemia; short telomere; stereotyped subset