title: Coming or going? Un-BLOC-ing delivery and recycling pathways during melanosome maturation.
abstract: Melanosome biogenesis requires successive waves of cargo delivery from endosomes to immature melanosomes, coupled with recycling of the trafficking machinery. Dennis et al. (2016. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201605090) report differential roles for BLOC-1 and BLOC-3 complexes in delivery and recycling of melanosomal biogenetic components, supplying directionality to melanosome maturation.
authors.affiliation: Univeristy College London Institute of Ophthalmology, London EC1V 9EL, England, UK c.futter@ucl.ac.uk.
authors.forename: Clare E
authors.initials: CE
authors.lastname: Futter
authors.affiliation: Medical Research Council Laboratory for Molecular Cell Biology, University College London, London WC1E 6BT, England, UK.
authors.forename: Daniel F
authors.initials: DF
authors.lastname: Cutler
mesh_terms: D000818:Animals; D002352:Carrier Proteins / Q000378:metabolism*; D002454:Cell Differentiation; D004705:Endocytosis; D011992:Endosomes / Q000378:metabolism; D006801:Humans; D020460:Melanosomes / Q000378:metabolism*; D008954:Models, Biological
chemical_list: D002352:Carrier Proteins