title: Piezotronic Effect Enhanced Label-Free Detection of DNA Using a Schottky-Contacted ZnO Nanowire Biosensor.
abstract: A sensitive and in situ selective label-free DNA sensor based on a Schottky-contacted ZnO nanowire (NW) device has been developed and utilized to detect the human immunodeficiency virus 1 gene in this work. Piezotronic effect on the performance of the DNA sensor is studied by measuring its output current under different compressive strains and target complementary DNA concentrations. By applying a -0.59% compressive strain to a ZnO NW-based DNA sensor, the relative current response is greatly enhanced by 454%. A theoretical model is proposed to explain the observed behaviors of the DNA sensor. This study provides a piezotronically modified method to effectively improve the overall performance of the Schottky-contacted ZnO NW-based DNA sensor.
authors.affiliation: Beijing Institute of Nanoenergy and Nanosystems, Chinese Academy of Sciences, National Center for Nanoscience and Technology (NCNST) , Beijing 100083, P. R. China.
authors.forename: Xiaotao
authors.initials: X
authors.lastname: Cao
authors.affiliation: Beijing Institute of Nanoenergy and Nanosystems, Chinese Academy of Sciences, National Center for Nanoscience and Technology (NCNST) , Beijing 100083, P. R. China.
authors.forename: Xia
authors.initials: X
authors.lastname: Cao
authors.affiliation: Beijing Institute of Nanoenergy and Nanosystems, Chinese Academy of Sciences, National Center for Nanoscience and Technology (NCNST) , Beijing 100083, P. R. China.
authors.forename: Huijuan
authors.initials: H
authors.lastname: Guo
authors.affiliation: Beijing Institute of Nanoenergy and Nanosystems, Chinese Academy of Sciences, National Center for Nanoscience and Technology (NCNST) , Beijing 100083, P. R. China.
authors.forename: Tao
authors.initials: T
authors.lastname: Li
authors.affiliation: Beijing Institute of Nanoenergy and Nanosystems, Chinese Academy of Sciences, National Center for Nanoscience and Technology (NCNST) , Beijing 100083, P. R. China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Jie
authors.forename: Ning
authors.initials: N
authors.lastname: Wang
authors.affiliation: Beijing Institute of Nanoenergy and Nanosystems, Chinese Academy of Sciences, National Center for Nanoscience and Technology (NCNST) , Beijing 100083, P. R. China.|School of Material Science and Engineering, Georgia Institute of Technology , Atlanta, Georgia 30332-0245, United States.
authors.forename: Zhong Lin
authors.initials: ZL
authors.lastname: Wang
mesh_terms: D015374:Biosensing Techniques; D004247:DNA / Q000032:analysis*; D006801:Humans; D053770:Nanowires; D015034:Zinc Oxide
chemical_list: D004247:DNA; D015034:Zinc Oxide
keywords: DNA sensor; ZnO nanowire; label-free; piezotronic effect