title: Clinical Response with intralesional Amphotericin B in the treatment of old world cutaneous leishmaniasis: a preliminary report.
abstract: Cutaneous leishmaniasis (CL) is a vector-borne tropical disease caused by a heterogeneous group of protozoan parasites that belong to the genus Leishmania. With an annual incidence of 1.5 million new cases, CL is a global health concern mainly in developing countries. The treatment options for CL are numerous but none is optimal. Pentavalent antimonials despite their side effects remain the preferred choice since decades. Alternate new treatment options are being explored to expand the therapeutic armamentarium of CL. In this study, we intend to describe our therapeutic experience with intralesional amphotericin B in the treatment of CL in a series of Indian patients, hitherto not commonly used in old world CL (OWCL). We also endeavour to review the literature on the use of amphotericin B in OWCL. Five consecutive patients diagnosed with cutaneous leishmansis at the out-patient department of Dermatology, Government Medical College, Jammu were treated with weekly injections of intralesional amphotericin B (2.5 mg/mL). Treatment response was assessed at each visit and the cases were followed up for 6 months. All the five patients responded well to the treatment and remained recurrence-free during follow-up. Intralesional amphotericin B was found to be safe and effective treatment for OWCL. Large randomized control trials need to be conducted to establish its efficacy.
authors.affiliation: Department of Dermatology, Venereology & Leprology, SMGS Hospital, Government Medical College, Jammu, Jammu & Kashmir, India.
authors.forename: Sabha
authors.initials: S
authors.lastname: Mushtaq
authors.affiliation: Department of Dermatology, Venereology & Leprology, SMGS Hospital, Government Medical College, Jammu, Jammu & Kashmir, India.
authors.forename: Devraj
authors.initials: D
authors.lastname: Dogra
authors.affiliation: Department of Dermatology, Venereology & Leprology, SMGS Hospital, Government Medical College, Jammu, Jammu & Kashmir, India.
authors.forename: Naina
authors.initials: N
authors.lastname: Dogra
mesh_terms: D000328:Adult; D000666:Amphotericin B / Q000008:administration & dosage* / Q000009:adverse effects; D000981:Antiprotozoal Agents / Q000008:administration & dosage* / Q000009:adverse effects; D001706:Biopsy; D005260:Female; D006801:Humans; D007194:India; D015552:Injections, Intralesional; D016773:Leishmaniasis, Cutaneous / Q000175:diagnosis / Q000188:drug therapy* / Q000469:parasitology; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012074:Remission Induction; D012867:Skin / Q000187:drug effects* / Q000469:parasitology / Q000473:pathology; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D000981:Antiprotozoal Agents; D000666:Amphotericin B
keywords: Amphotericin B; cutaneous leishmaniasis; intralesional; old world