title: There is more into 'doing' than 'knowing': The function of the right inferior frontal sulcus is specific for implementing versus memorising verbal instructions.
abstract: In the present study we examine the mechanism underlying the human ability to implement newly instructed stimulus-response mappings for their future application. We introduce a novel procedure in which we can investigate the processes underlying such implementation while controlling for more general working-memory demands. The results indicate that a region within the dorso-lateral prefrontal cortex (DLPFC) in the vicinity of the inferior frontal sulcus (IFS) is specifically recruited when new instructions are implemented compared to when new instructions are memorised. In addition, we observed that this area is more strongly activated when task performance is effective. Together, these findings suggest that the DLPFC, and more specific the IFS, plays an important role during the formation of procedural representations in working memory.
authors.affiliation: Department of Experimental Psychology, Ghent University, 9000 Ghent, Belgium. Electronic address: Jelle.Demanet@Ugent.be.
authors.forename: Jelle
authors.initials: J
authors.lastname: Demanet
authors.affiliation: Department of Experimental Clinical and Health Psychology, Ghent University, 9000 Ghent, Belgium.
authors.forename: Baptist
authors.initials: B
authors.lastname: Liefooghe
authors.affiliation: Radboud University Nijmegen, Donders Institute for Brain, Cognition, and Behaviour, Postbus 9104, 6500, HE, Nijmegen, The Netherlands.
authors.forename: Egbert
authors.initials: E
authors.lastname: Hartstra
authors.affiliation: Department of Psychology, Humboldt-Universität, Berlin, Germany; Department of Psychology, Private University of Applied Sciences, Göttingen, Germany.
authors.forename: Dorit
authors.initials: D
authors.lastname: Wenke
authors.affiliation: Department of Experimental Clinical and Health Psychology, Ghent University, 9000 Ghent, Belgium.
authors.forename: Jan
authors.initials: J
authors.lastname: De Houwer
authors.affiliation: Department of Experimental Psychology, Ghent University, 9000 Ghent, Belgium; Ghent Institute for Functional and Metabolic Imaging of the Brain, Ghent University, 9000 Ghent, Belgium.
authors.forename: Marcel
authors.initials: M
authors.lastname: Brass
mesh_terms: D000328:Adult; D001931:Brain Mapping / Q000379:methods; D003071:Cognition / Q000502:physiology*; D056344:Executive Function / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D008570:Memory, Short-Term / Q000502:physiology*; D009415:Nerve Net / Q000502:physiology*; D017397:Prefrontal Cortex / Q000502:physiology*; D011930:Reaction Time / Q000502:physiology; D013647:Task Performance and Analysis; D014706:Verbal Learning / Q000502:physiology*