title: Anti-ganglioside antibodies in Guillain-Barré syndrome and chronic inflammatory demyelinating polyneuropathy in Chinese patients.
abstract: In this study we investigated the relationships between anti-ganglioside antibodies and Guillain-Barré syndrome (GBS) and chronic inflammatory demyelinating polyneuropathy (CIDP).
  
  
  
  Samples from 48 Chinese patients diagnosed with GBS and 18 patients diagnosed with CIDP were retrospectively reviewed.
  
  
  
  In the GBS patients, 62.5% were classified as having acute inflammatory demyelinating polyneuropathy (AIDP), 27.1% were found to have acute motor axonal neuropathy (AMAN), and 10.4% were unclassified. Serum IgG anti-ganglioside antibodies were detected in 46.2% of the AMAN patients and in 6.7% of the AIDP patients (P < 0.05); 5.6% of the 18 CIDP patients were IgG antibody positive, and 27.8% were IgM antibody positive. Facial palsy and sensory impairment were significantly associated with IgM antibodies.
  
  
  
  These results suggest that IgG anti-GM1 antibodies are associated with AMAN, but not with AIDP, and that IgM antibodies against GM1, GM2, and GM3 are associated with facial nerve palsy. Muscle Nerve 55: 470-475, 2017.
authors.affiliation: Department of Neurology, Peking University First Hospital, No. 8 Xishiku Street, Xicheng District, Beijing, China.
authors.forename: Chenghe
authors.initials: C
authors.lastname: Fan
authors.affiliation: Department of Neurology, Peking University First Hospital, No. 8 Xishiku Street, Xicheng District, Beijing, China.
authors.forename: Haiqiang
authors.initials: H
authors.lastname: Jin
authors.affiliation: Department of Neurology, Peking University First Hospital, No. 8 Xishiku Street, Xicheng District, Beijing, China.
authors.forename: Hongjun
authors.initials: H
authors.lastname: Hao
authors.affiliation: Department of Neurology, Peking University First Hospital, No. 8 Xishiku Street, Xicheng District, Beijing, China.
authors.forename: Feng
authors.initials: F
authors.lastname: Gao
authors.affiliation: Department of Neurology, Peking University First Hospital, No. 8 Xishiku Street, Xicheng District, Beijing, China.
authors.forename: Yongan
authors.initials: Y
authors.lastname: Sun
authors.affiliation: Department of Neurology, Peking University First Hospital, No. 8 Xishiku Street, Xicheng District, Beijing, China.
authors.forename: Yuanyuan
authors.initials: Y
authors.lastname: Lu
authors.affiliation: Department of Neurology, Peking University First Hospital, No. 8 Xishiku Street, Xicheng District, Beijing, China.
authors.forename: Yuanyuan
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Department of Neurology, Peking University First Hospital, No. 8 Xishiku Street, Xicheng District, Beijing, China.
authors.forename: Pu
authors.initials: P
authors.lastname: Lv
authors.affiliation: Department of Neurology, Peking University First Hospital, No. 8 Xishiku Street, Xicheng District, Beijing, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Cui
authors.affiliation: Department of Neurology, Peking University First Hospital, No. 8 Xishiku Street, Xicheng District, Beijing, China.
authors.forename: Yuming
authors.initials: Y
authors.lastname: Teng
authors.affiliation: Department of Neurology, Peking University First Hospital, No. 8 Xishiku Street, Xicheng District, Beijing, China.
authors.forename: Yining
authors.initials: Y
authors.lastname: Huang
mesh_terms: D000200:Action Potentials / Q000502:physiology; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D044466:Asian People; D001323:Autoantibodies / Q000097:blood* / Q000134:cerebrospinal fluid*; D004576:Electromyography; D005260:Female; D005732:Gangliosides / Q000276:immunology*; D020275:Guillain-Barre Syndrome / Q000097:blood / Q000134:cerebrospinal fluid / Q000276:immunology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009431:Neural Conduction / Q000502:physiology; D020277:Polyradiculoneuropathy, Chronic Inflammatory Demyelinating / Q000097:blood / Q000134:cerebrospinal fluid / Q000276:immunology
chemical_list: D001323:Autoantibodies; D005732:Gangliosides
keywords: Chinese; Guillain-Barré syndrome; antibodies; chronic inflammatory demyelinating polyneuropathy; ganglioside