title: Snoring Sounds Predict Obstruction Sites and Surgical Response in Patients with Obstructive Sleep Apnea Hypopnea Syndrome.
abstract: Snoring sounds generated by different vibrators of the upper airway may be useful indicators of obstruction sites in patients with obstructive sleep apnea hypopnea syndrome (OSAHS). This study aimed to investigate associations between snoring sounds, obstruction sites, and surgical responses (≥50% reduction in the apnea-hypopnea index [AHI] and <10 events/hour) in patients with OSAHS. This prospective cohort study recruited 36 OSAHS patients for 6-hour snoring sound recordings during in-lab full-night polysomnography, drug-induced sleep endoscopy (DISE), and relocation pharyngoplasty. All patients received follow-up polysomnography after 6 months. Fifteen (42%) patients with at least two complete obstruction sites defined by DISE were significantly, positively associated with maximal snoring sound intensity (40-300 Hz; odds ratio [OR], 1.25, 95% confidence interval [CI] 1.05-1.49) and body mass index (OR, 1.48, 95% CI 1.02-2.15) after logistic regression analysis. Tonsil obstruction was significantly, inversely correlated with mean snoring sound intensity (301-850 Hz; OR, 0.84, 95% CI 0.74-0.96). Moreover, baseline tonsil obstruction detected by either DISE or mean snoring sound intensity (301-850 Hz), and AHI could significantly predict the surgical response. Our findings suggest that snoring sound detection may be helpful in determining obstruction sites and predict surgical responses.
authors.affiliation: Department of Otorhinolaryngology - Head and Neck Surgery, Sleep Center, Linkou-Chang Gung Memorial Hospital, Tao-Yuan 33305, Taiwan, ROC.|Faculty of Medicine, College of Medicine, Chang Gung University, Taoyuan 33303, Taiwan, ROC.
authors.forename: Li-Ang
authors.initials: LA
authors.lastname: Lee
authors.affiliation: Faculty of Medicine, College of Medicine, Chang Gung University, Taoyuan 33303, Taiwan, ROC.|Department of Thoracic Medicine, Sleep Center, Linkou-Chang Gung Memorial Hospital, Tao-Yuan 33305, Taiwan, ROC.
authors.forename: Yu-Lun
authors.initials: YL
authors.lastname: Lo
authors.affiliation: Graduate Institute of Medical Mechatronics, Taiouan Interdisciplinary Otolaryngology Laboratory, Chang Gung University, Taoyuan 33303, Taiwan.
authors.forename: Jen-Fang
authors.initials: JF
authors.lastname: Yu
authors.affiliation: Faculty of Medicine, School of Medicine, National Yang-Ming University, Taipei 11221, Taiwan, ROC.|Department of Otolaryngology, Taipei City Hospital, Ren-Ai Branch, Taipei 10629, Taiwan, ROC.
authors.forename: Gui-She
authors.initials: GS
authors.lastname: Lee
authors.affiliation: Department of Thoracic Medicine, Sleep Center, Linkou-Chang Gung Memorial Hospital, Tao-Yuan 33305, Taiwan, ROC.|Department of Chest Medicine, Taichung Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Taichung 42743, Taiwan, ROC.
authors.forename: Yung-Lun
authors.initials: YL
authors.lastname: Ni
authors.affiliation: Faculty of Medicine, College of Medicine, Chang Gung University, Taoyuan 33303, Taiwan, ROC.|Department of Thoracic Medicine, Sleep Center, Linkou-Chang Gung Memorial Hospital, Tao-Yuan 33305, Taiwan, ROC.
authors.forename: Ning-Hung
authors.initials: NH
authors.lastname: Chen
authors.affiliation: Department of Otorhinolaryngology - Head and Neck Surgery, Sleep Center, Linkou-Chang Gung Memorial Hospital, Tao-Yuan 33305, Taiwan, ROC.|Faculty of Medicine, College of Medicine, Chang Gung University, Taoyuan 33303, Taiwan, ROC.
authors.forename: Tuan-Jen
authors.initials: TJ
authors.lastname: Fang
authors.affiliation: Department of Laboratory Medicine, Linkou-Chang Gung Memorial Hospital, Tao-Yuan 33305, Taiwan, ROC.|Department of Medical Biotechnology and Laboratory Science, College of Medicine, Chang Gung University, Tao-Yuan 33303, Taiwan, ROC.|Graduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, Tao-Yuan 33303, Taiwan, ROC.
authors.forename: Chung-Guei
authors.initials: CG
authors.lastname: Huang
authors.affiliation: Department of Sports Sciences, University of Taipei, Tai-Pei 11153, Taiwan, ROC.
authors.forename: Wen-Nuan
authors.initials: WN
authors.lastname: Cheng
authors.affiliation: Department of Otorhinolaryngology - Head and Neck Surgery, Sleep Center, Linkou-Chang Gung Memorial Hospital, Tao-Yuan 33305, Taiwan, ROC.|Faculty of Medicine, College of Medicine, Chang Gung University, Taoyuan 33303, Taiwan, ROC.|Department of Sleep Medicine, Royal Infirmary of Edinburgh, Edinburgh EH16 4SA, UK.
authors.forename: Hsueh-Yu
authors.initials: HY
authors.lastname: Li
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012891:Sleep Apnea Syndromes / Q000175:diagnosis* / Q000473:pathology* / Q000601:surgery; D020181:Sleep Apnea, Obstructive / Q000175:diagnosis* / Q000473:pathology* / Q000601:surgery; D012913:Snoring / Q000175:diagnosis* / Q000473:pathology* / Q000601:surgery; D013018:Sound Spectrography / Q000379:methods*; D016896:Treatment Outcome