title: Temporary amygdala inhibition reduces stress effects in female mice.
abstract: The current study investigated the effect of temporary inhibition of amygdala in response to metabolic changes caused by stress in female mice. Unilateral and bilateral amygdala cannulation was carried out, and after a week of recovery, 2% lidocaine hydrochloride was injected into the mice amygdalae five minutes before the induction of stress. A communication box was employed to induce stress for four consecutive days and plasma corticosterone, food and water intake, weight changes, and anorexia were measured as stress-induced metabolic changes. Results demonstrated that stress, increases stress, increased plasma corticosterone concentrations, weight, food, and water intake. Temporary inhibition of the amygdala slightly decreased plasma corticosterone concentrations, but did not fully reduce the effect of stress. The bilateral injection of lidocaine hydrochloride to the amygdala reduced the effect of stress and reduced water intake and weight. Unilateral injection of lidocaine hydrochloride into the left and right amygdala reduced food intake. In conclusion, the present study demonstrated that the left side and right side of amygdala nuclei play a different role in metabolic responses in stress.
authors.affiliation: Department of Biology, Islamic Azad University, North Tehran Branch, Tehran, Iran.
authors.forename: Jila Rezaeian
authors.initials: JR
authors.lastname: Dalooei
authors.affiliation: Neuroscience Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran.
authors.forename: Hedayat
authors.initials: H
authors.lastname: Sahraei
authors.affiliation: Neuroscience Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran.
authors.forename: Gholam Hossein
authors.initials: GH
authors.lastname: Meftahi
authors.affiliation: Department of Biology, Islamic Azad University, North Tehran Branch, Tehran, Iran.
authors.forename: Maryam
authors.initials: M
authors.lastname: Khosravi
authors.affiliation: Department of Physiology and Biophysics, Faculty of Medicine, Baqiyatallah University of Medical Sciences, Tehran, Iran.
authors.forename: Zahra
authors.initials: Z
authors.lastname: Bahari
authors.affiliation: Neuroscience Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran.
authors.forename: Boshra
authors.initials: B
authors.lastname: Hatef
authors.affiliation: Neuroscience Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran.
authors.forename: Alireza
authors.initials: A
authors.lastname: Mohammadi
authors.affiliation: Department of Biology, Islamic Azad University, North Tehran Branch, Tehran, Iran.
authors.forename: Fateme
authors.initials: F
authors.lastname: Nicaeili
authors.affiliation: Department of Biology, Islamic Azad University, North Tehran Branch, Tehran, Iran.
authors.forename: Fateme
authors.initials: F
authors.lastname: Eftekhari
authors.affiliation: Department of Biology, Islamic Azad University, North Tehran Branch, Tehran, Iran.
authors.forename: Fateme
authors.initials: F
authors.lastname: Ghamari
authors.affiliation: Neuroscience Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran.
authors.forename: Mohamadmehdi
authors.initials: M
authors.lastname: Hadipour
authors.affiliation: Neuroscience Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran.
authors.forename: Gholamreza
authors.initials: G
authors.lastname: Kaka
keywords: Anorexia; Communication box; Corticosterone; Food intake; Hypothalamic–pituitary–adrenal axis; Lidocaine hydrochloride