title: Neuroprotective effects of bloodletting at Jing points combined with mild induced hypothermia in acute severe traumatic brain injury.
abstract: Bloodletting at Jing points has been used to treat coma in traditional Chinese medicine. Mild induced hypothermia has also been shown to have neuroprotective effects. However, the therapeutic effects of bloodletting at Jing points and mild induced hypothermia alone are limited. Therefore, we investigated whether combined treatment might have clinical effectiveness for the treatment of acute severe traumatic brain injury. Using a rat model of traumatic brain injury, combined treatment substantially alleviated cerebral edema and blood-brain barrier dysfunction. Furthermore, neurological function was ameliorated, and cellular necrosis and the inflammatory response were lessened. These findings suggest that the combined effects of bloodletting at Jing points (20 μL, twice a day, for 2 days) and mild induced hypothermia (6 hours) are better than their individual effects alone. Their combined application may have marked neuroprotective effects in the clinical treatment of acute severe traumatic brain injury.
authors.affiliation: Tianjin Key Laboratory of Neurotrauma Repair, Institute of Traumatic Brain Injury & Neuroscience of Chinese People's Armed Police Forces, Neurosurgery & Neurology Hospital, Affiliated Hospital of Logistics University of Chinese People's Armed Police Forces, Tianjin, China; Graduate School, Tianjin University of Traditional Chinese Medicine, Tianjin, China.
authors.forename: Yue
authors.initials: Y
authors.lastname: Tu
authors.affiliation: Tianjin Key Laboratory of Neurotrauma Repair, Institute of Traumatic Brain Injury & Neuroscience of Chinese People's Armed Police Forces, Neurosurgery & Neurology Hospital, Affiliated Hospital of Logistics University of Chinese People's Armed Police Forces, Tianjin, China; Graduate School, Tianjin University of Traditional Chinese Medicine, Tianjin, China.
authors.forename: Xiao-Mei
authors.initials: XM
authors.lastname: Miao
authors.affiliation: Tianjin Key Laboratory of Neurotrauma Repair, Institute of Traumatic Brain Injury & Neuroscience of Chinese People's Armed Police Forces, Neurosurgery & Neurology Hospital, Affiliated Hospital of Logistics University of Chinese People's Armed Police Forces, Tianjin, China.
authors.forename: Tai-Long
authors.initials: TL
authors.lastname: Yi
authors.affiliation: Tianjin Key Laboratory of Neurotrauma Repair, Institute of Traumatic Brain Injury & Neuroscience of Chinese People's Armed Police Forces, Neurosurgery & Neurology Hospital, Affiliated Hospital of Logistics University of Chinese People's Armed Police Forces, Tianjin, China.
authors.forename: Xu-Yi
authors.initials: XY
authors.lastname: Chen
authors.affiliation: Tianjin Key Laboratory of Neurotrauma Repair, Institute of Traumatic Brain Injury & Neuroscience of Chinese People's Armed Police Forces, Neurosurgery & Neurology Hospital, Affiliated Hospital of Logistics University of Chinese People's Armed Police Forces, Tianjin, China.
authors.forename: Hong-Tao
authors.initials: HT
authors.lastname: Sun
authors.affiliation: Tianjin Key Laboratory of Neurotrauma Repair, Institute of Traumatic Brain Injury & Neuroscience of Chinese People's Armed Police Forces, Neurosurgery & Neurology Hospital, Affiliated Hospital of Logistics University of Chinese People's Armed Police Forces, Tianjin, China; Graduate School, Tianjin University of Traditional Chinese Medicine, Tianjin, China.
authors.forename: Shi-Xiang
authors.identifier: 0000-0003-2529-719X
authors.initials: SX
authors.lastname: Cheng
authors.affiliation: Tianjin Key Laboratory of Neurotrauma Repair, Institute of Traumatic Brain Injury & Neuroscience of Chinese People's Armed Police Forces, Neurosurgery & Neurology Hospital, Affiliated Hospital of Logistics University of Chinese People's Armed Police Forces, Tianjin, China; Graduate School, Tianjin University of Traditional Chinese Medicine, Tianjin, China.
authors.forename: Sai
authors.identifier: 0000-0002-8028-4183
authors.initials: S
authors.lastname: Zhang
keywords: Jing points; acute severe traumatic brain injury; blood-brain barrier; bloodletting; brain edema; brain water content; mild induced hypothermia; nerve regeneration; neural regeneration