title: Vascular rarefaction at the choriocapillaris in acute posterior multifocal placoid pigment epitheliopathy viewed on OCT angiography.
abstract: Few cases have been reported describing choroidal vasculature in acute posterior multifocal placoid pigment epitheliopathy (APMPPE) using optical coherence tomography (OCT) angiography. We report choroidal vasculature changes in an APMPPE patient with the clinical course characterized by OCT angiography. A 39-year-old female was referred to us for bilateral multiple white spots in bilateral fundus. The best-corrected visual acuity was 20/20 in the right eye and 20/50 in the left eye. Multiple yellowish-white placoid lesions were observed in bilateral fundus, and fluorescein angiography showed a "block early, stain late" pattern at the placoid lesions characteristic of APMPPE. The placoid lesion represented vascular rarefaction at the choriocapillaris in the OCT angiography en face view. While the clinical course of symptoms and most of the low vascular rarefaction lesions regressed in 6 months, some new lesions were subclinically noted. Blurred vision recurred at 9 months from the first visit, and the vascular rarefaction lesions developed in different areas than those observed in the initial visit. Multiple yellowish-white placoid lesions in an APMPPE patient represented vascular rarefaction at the choriocapillaris in OCT angiography. The vascular rarefaction recovered and then recurred during the clinical course. OCT angiography can visualize changes of the choroidal vessels during APMPPE.
authors.affiliation: Department of Ophthalmology, Asahikawa Medical University, Asahikawa, Hokkaido, Japan. rkino@asahikawa-med.ac.jp.|Department of Medicine and Engineering Combined Research, Asahikawa Medical University, Midorigaoka Higashi 2-1-1-1, Asahikawa, Hokkaido, 078-8510, Japan. rkino@asahikawa-med.ac.jp.
authors.forename: Reiko
authors.identifier: http://orcid.org/0000-0003-1344-1641
authors.initials: R
authors.lastname: Kinouchi
authors.affiliation: Department of Ophthalmology, Asahikawa Medical University, Asahikawa, Hokkaido, Japan.
authors.forename: Noriko
authors.initials: N
authors.lastname: Nishikawa
authors.affiliation: Department of Ophthalmology, Asahikawa Medical University, Asahikawa, Hokkaido, Japan.
authors.forename: Akihiro
authors.initials: A
authors.lastname: Ishibazawa
authors.affiliation: Department of Ophthalmology, Asahikawa Medical University, Asahikawa, Hokkaido, Japan.
authors.forename: Akitoshi
authors.initials: A
authors.lastname: Yoshida
mesh_terms: D000208:Acute Disease; D000328:Adult; D002829:Choroid / Q000098:blood supply*; D002833:Choroiditis / Q000175:diagnosis*; D005260:Female; D005451:Fluorescein Angiography / Q000379:methods*; D005654:Fundus Oculi; D006801:Humans; D000080364:Multifocal Choroiditis; D010857:Pigment Epithelium of Eye / Q000473:pathology*; D012008:Recurrence; D041623:Tomography, Optical Coherence / Q000379:methods*; D014792:Visual Acuity
keywords: Acute posterior multifocal placoid pigment epitheliopathy; Choriocapillaris; OCT angiography; Subclinical