title: Macroscopic Sertoli cell nodule of the testis containing numerous spermatogonia.
abstract: Sertoli cell nodule consists of clusters of seminiferous tubules composed of immature Sertoli cells and, in some cases, spermatogonia. We report a case of macroscopic Sertoli cell nodule that occurred in the descended left testis of a 26-year-old man. The nodule was centrally located and measured 1.7cm in greatest dimension, the largest such lesion reported to date. Spermatogonia were prominent, a feature that is particularly common in the larger nodules. Macroscopic Sertoli cell nodules (greater than 0.5cm) typically occur in a descended testis. The age range of patients in cases reported since the year 2000 is 19-36 years. Unlike incidental Sertoli cell nodules, macroscopic Sertoli cell nodules containing numerous germ cells can be mistaken for several other Sertoli cell and germ cell lesions and neoplasms.
authors.affiliation: Department of Pathology, Indiana University School of Medicine, Indianapolis, Indiana, USA. Electronic address: lroth@iupui.edu.
authors.forename: Lawrence M
authors.initials: LM
authors.lastname: Roth
authors.affiliation: Patho-Lab Diagnostics Ltd (B.C.), Ness-Ziona, Israel.
authors.forename: Bernard
authors.initials: B
authors.lastname: Czernobilsky
mesh_terms: D000328:Adult; D049109:Cell Proliferation; D006801:Humans; D008297:Male; D012707:Sertoli Cell Tumor / Q000473:pathology* / Q000601:surgery; D012708:Sertoli Cells / Q000473:pathology; D013093:Spermatogonia / Q000473:pathology*; D013736:Testicular Neoplasms / Q000473:pathology* / Q000601:surgery
keywords: Sertoli cell nodule; Spermatogonia; Testis