title: [Progressive Risks of Latent Keshan Disease: a Long Term Follow-up Study].
abstract: OBJECTIVE
  To observe ten-year prognosis of patients with latent Keshan disease (KD) and to determine its associated risk factors.
  
  
  METHODS
  A total of 448 patients with newly diagnosed latent KD were monitored and followed up for 10 years. Their ECG abnormalities were classified as major or minor using the Minnesota Code. COX proportional hazards regression models were established to identify risk factors associated with the development of chronic KD.
  
  
  RESULTS
  A final sample of 414 cases was included in analyses, with an average of (112.9 ± 17.5) months of follow-up. At the end of follow-up, 92 (22. 2%) patients developed chronic KD. Older age (> 15 years), male, family history of KD, smoking, lower level of blood selenium (< 60 µg/L), major ECG abnormalities, and 18.5 kg/m² ≤ body mass index (BMI) 23.9 kg/m² were associated with higher cumulative incidence of chronic KD. The COX regression models showed that major ECG abnormalities, BMI, selenium deficiency, hypertension, and ventricular premature complex (VPC) abnormalities contributed to increased risk of chronic KD. A positive linear correlation (r = 0.719, P < 0.01) between GPx activity and blood selenium concentration was found.
  
  
  CONCLUSIONS
  Major ECG abnormalities, BMI, selenium deficiency, hypertension and VPC abnormalities are associated with the development of chronic KD.
authors.forename: Xin
authors.initials: X
authors.lastname: Liu
authors.forename: Guang
authors.initials: G
authors.lastname: Yang
authors.forename: Li-xin
authors.initials: LX
authors.lastname: Wang
authors.forename: Jin
authors.initials: J
authors.lastname: Wei
authors.forename: Wu-hong
authors.initials: WH
authors.lastname: Tan
authors.forename: Yan-he
authors.initials: YH
authors.lastname: Zhu
mesh_terms: D015992:Body Mass Index; D009202:Cardiomyopathies / Q000175:diagnosis*; D002908:Chronic Disease; D004562:Electrocardiography; D004769:Enterovirus Infections / Q000175:diagnosis*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006973:Hypertension; D015994:Incidence; D008297:Male; D011379:Prognosis; D016016:Proportional Hazards Models; D012307:Risk Factors; D012643:Selenium / Q000172:deficiency
chemical_list: D012643:Selenium