title: A female adnexal tumor of probable Wolffian origin showing positive O-6-methylguanine-DNA methyltransferase methylation.
abstract: Female adnexal tumor of probable Wolffian origin (FATWO) is a rare disease entity that arises from the mesonephric duct system. FATWO is different than other gynecological cancers in terms of embryology. Here, we describe the case of a 52-year-old woman with malignant FATWO. The patient underwent explorative laparotomy and surgical staging after a frozen section revealed malignancy. Detailed examination of the pathologic findings were consistent with FATWO. Counseling and further testing were provided to the patient to assess the risk of germline mutation and epigenetic change. An O-6-methylguanine-DNA methyltransferase gene methylation test was positive, and all other tests were normal. This is the first study to report a case of O-6-methylguanine-DNA methyltransferase methylation with FATWO in Korea.
authors.affiliation: Department of Obstetrics and Gynecology, Samsung Medical Center, Seoul, Korea.
authors.forename: Min Jung
authors.initials: MJ
authors.lastname: Kwon
authors.affiliation: Department of Obstetrics and Gynecology, Samsung Medical Center, Seoul, Korea.
authors.forename: Min Jeong
authors.initials: MJ
authors.lastname: Yun
authors.affiliation: Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Samsung Changwon Hospital, Sungkyunkwan University School of Medicine, Changwon, Korea.
authors.forename: Min Kyu
authors.identifier: 0000-0002-1937-3611
authors.initials: MK
authors.lastname: Kim
keywords: Epigenesis, Genetic; O(6)-methylguanine-DNA methyltransferase methylation; Wolffian tumor