title: White-Coat Isolated Systolic Hypertension Is a Risk Factor for Carotid Atherosclerosis.
abstract: The clinical importance of white-coat hypertension (WCH) remains a controversial issue. The aim of this study was to evaluate the association of isolated systolic, isolated diastolic, and systolic/diastolic WCH with common carotid artery intima-media thickness (CCA-IMT) and to compare each subgroup of WCH against other blood pressure (BP) phenotypes in terms of CCA-IMT values. A total of 1382 consecutive patients underwent 24-hour ambulatory BP monitoring and carotid artery ultrasonographic measurements. According to the type of elevated office BP, WCH was divided into three groups: isolated systolic, isolated diastolic, and systolic/diastolic WCH. Patients with isolated systolic WCH (n=112) had significantly higher CCA-IMT values (0.737 mm) than those with isolated diastolic WCH (n=66) (0.685 mm) and nonsignificantly greater compared with those with systolic/diastolic WCH (n=228) (0.708 mm). Patients with isolated systolic WCH had CCA-IMT values similar to those with hypertension, patients with isolated diastolic WCH had similar values to those with normotension, and patients with systolic/diastolic WCH had an intermediate risk between normotension and hypertension.
authors.affiliation: Department of Clinical Therapeutics, Medical School, National and Kapodistrian University of Athens, Alexandra Hospital, Athens, Greece. stathismanios@yahoo.gr.
authors.forename: Efstathios
authors.initials: E
authors.lastname: Manios
authors.affiliation: Department of Clinical Therapeutics, Medical School, National and Kapodistrian University of Athens, Alexandra Hospital, Athens, Greece.
authors.forename: Fotios
authors.initials: F
authors.lastname: Michas
authors.affiliation: Department of Clinical Therapeutics, Medical School, National and Kapodistrian University of Athens, Alexandra Hospital, Athens, Greece.
authors.forename: Kimon
authors.initials: K
authors.lastname: Stamatelopoulos
authors.affiliation: Department of Clinical Therapeutics, Medical School, National and Kapodistrian University of Athens, Alexandra Hospital, Athens, Greece.
authors.forename: Eleni
authors.initials: E
authors.lastname: Koroboki
authors.affiliation: Department of Clinical Therapeutics, Medical School, National and Kapodistrian University of Athens, Alexandra Hospital, Athens, Greece.
authors.forename: Aikaterini
authors.initials: A
authors.lastname: Lykka
authors.affiliation: Department of Clinical Therapeutics, Medical School, National and Kapodistrian University of Athens, Alexandra Hospital, Athens, Greece.
authors.forename: Charitini
authors.initials: C
authors.lastname: Vettou
authors.affiliation: Department of Clinical Therapeutics, Medical School, National and Kapodistrian University of Athens, Alexandra Hospital, Athens, Greece.
authors.forename: Konstantinos
authors.initials: K
authors.lastname: Vemmos
authors.affiliation: Department of Clinical Therapeutics, Medical School, National and Kapodistrian University of Athens, Alexandra Hospital, Athens, Greece.
authors.forename: Nikolaos
authors.initials: N
authors.lastname: Zakopoulos
mesh_terms: D000328:Adult; D000368:Aged; D001794:Blood Pressure; D018660:Blood Pressure Monitoring, Ambulatory; D002340:Carotid Artery Diseases / Q000000981:diagnostic imaging*; D059168:Carotid Intima-Media Thickness; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D059466:White Coat Hypertension / Q000145:classification* / Q000150:complications