title: Lower Urinary and Serum Progesterone-Induced Blocking Factor in Women with Preterm Birth.
abstract: The aim of the study was to compare urine and serum concentrations of PIBF at 24-28 gestational weeks in women with preterm birth, with those of women who delivered at term and to evaluate the impact of PIBF on the outcome of pregnancy. Case-control study was performed in period from 1.6.2010-31.7.2013. Biological samples (urine and serum) were collected from 126 pregnant women. All biological samples were obtained at 24-28 gestation weeks. We measured PIBF concentration and compared women who delivered preterm and those who delivered at term. Thirteen of 126 pregnant women (10.3%) who were included in the study delivered preterm. Among women that actually delivered preterm, median concentrations of PIBF were significantly lower (12.3ng/ml; 101.3ng/ml) than in women who delivered at term (77.0ng/ml; 412.7ng/ml). The serum and urine 24-28 gestational weeks PIBF in those who delivered preterm were generally low from 24 to 37 gestational weeks, while the serum and urine PIBF concentration reached a peak in those delivering between 37-38 gestational weeks, even significantly different from those delivering at 39 to 40 and after 40 gestational weeks. Preterm birth may be predictable at 24-28 gestational week by lower than normal pregnancy PIBF values and measurement of PIBF concentration in biological fluids at that time may be of importance in clinical practice.
authors.affiliation: Clinic of Gynecology and Obstetrics, University Clinical Center, Tuzla, Bosnia and Herzegovina; Institute of Clinical Medicine, University of Oslo, Oslo, Norway. Electronic address: i.hudic@bih.net.ba.
authors.forename: Igor
authors.initials: I
authors.lastname: Hudić
authors.affiliation: Department of Medical Biology, Medical School, Pecs University, MTA-PTE Human Reproduction Scientific Research Group, Janos Szentagothai Research Centre, University of Pecs, Hungary.
authors.forename: Julia
authors.initials: J
authors.lastname: Szekeres-Bartho
authors.affiliation: Institute of Clinical Medicine, University of Oslo, Oslo, Norway; Division of Obstetrics and Gynecology, Rikshospitalet, Oslo University Hospital, Oslo, Norway.
authors.forename: Babill
authors.initials: B
authors.lastname: Stray-Pedersen
authors.affiliation: Clinic of Gynecology and Obstetrics, University Clinical Center, Tuzla, Bosnia and Herzegovina.
authors.forename: Zlatan
authors.initials: Z
authors.lastname: Fatušić
authors.affiliation: Department of Medical Biology, Medical School, Pecs University, MTA-PTE Human Reproduction Scientific Research Group, Janos Szentagothai Research Centre, University of Pecs, Hungary.
authors.forename: Beata
authors.initials: B
authors.lastname: Polgar
authors.affiliation: Clinic of Gynecology and Obstetrics, University Clinical Center of Republic of Srpska, Banja Luka, Bosnia and Herzegovina.
authors.forename: Vesna
authors.initials: V
authors.lastname: Ećim-Zlojutro
mesh_terms: D000293:Adolescent; D000328:Adult; D015415:Biomarkers / Q000097:blood*; D016022:Case-Control Studies; D005260:Female; D005865:Gestational Age; D006801:Humans; D011237:Predictive Value of Tests; D011247:Pregnancy; D011256:Pregnancy Outcome; D011257:Pregnancy Proteins / Q000097:blood* / Q000652:urine*; D047928:Premature Birth / Q000175:diagnosis*; D011374:Progesterone / Q000378:metabolism; D011379:Prognosis; D013491:Suppressor Factors, Immunologic / Q000097:blood* / Q000652:urine*; D055815:Young Adult
chemical_list: D015415:Biomarkers; C110058:PIBF1 protein, human; D011257:Pregnancy Proteins; D013491:Suppressor Factors, Immunologic; D011374:Progesterone