title: A Catalogue of Altered Salivary Proteins Secondary to Invasive Ductal Carcinoma: A Novel In Vivo Paradigm to Assess Breast Cancer Progression.
abstract: The objective of this manuscript is to introduce a catalogue of salivary proteins that are altered secondary to carcinoma of the breast. The catalogue of salivary proteins is a compilation of twenty years of research by the authors and consists of 233 high and low abundant proteins which have been identified by LC-MS/MS mass spectrometry, 2D-gel analysis and by enzyme-linked immunosorbent assay. The body of research suggests that saliva is a fluid suffused with solubilized by-products of oncogenic expression and that these proteins may be useful in the study of breast cancer progress, treatment efficacy and the tailoring of individualized patient care.
authors.affiliation: University of Texas School of Dentistry at Houston Department of Diagnostic and Behavioral Sciences Behavioral &Biomedical Sciences Building, Rm. 5322 Houston, Texas 77054, USA.
authors.forename: Charles F
authors.initials: CF
authors.lastname: Streckfus
authors.affiliation: University of Texas School of Dentistry at Houston Department of Diagnostic and Behavioral Sciences Behavioral &Biomedical Sciences Building, Rm. 5322 Houston, Texas 77054, USA.
authors.forename: Lenora
authors.initials: L
authors.lastname: Bigler
mesh_terms: D001943:Breast Neoplasms / Q000378:metabolism*; D018270:Carcinoma, Ductal, Breast / Q000378:metabolism*; D015180:Electrophoresis, Gel, Two-Dimensional; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D013058:Mass Spectrometry; D009363:Neoplasm Proteins / Q000378:metabolism*; D057285:Precision Medicine / Q000379:methods; D012471:Salivary Proteins and Peptides / Q000378:metabolism*
chemical_list: D009363:Neoplasm Proteins; D012471:Salivary Proteins and Peptides