title: Research Advances in CKLFSF-like MARVEL Transmembrane Domain Containing Member 3.
abstract: CKLF-like MARVEL transmembrane domain containing member/chemokine-like factor super family member (CKLFSF/CMTM) is a novel tumor suppressor gene. CMTM3 is broadly expressed in normal human tissues and evolutionary conserved,especially in testis,spleen,and some cells of peripheral blood mononuclear cells. However,its expression is undetectable or down-regulated in most carcinoma cell lines and tissues. Restoration of CMTM3 may inhibit the proliferation,migration,and invasion of carcinoma cells. Although the exact mechanism of its anti-tumor activity remains unclear,CKLFSF3/CMTM3 is closely connected with immune system and associated with sex during tumorigenesis. The study advances of CKLFSF3/CMTM3 are elaborated in this review as CMTM3 may be a new target in the gene therapies for tumors,especially genitourinary tumors,while further studies on CMTM3 and its anti-tumor mechanisms are warranted.
authors.affiliation: Department of Urology,Peking University People’s Hospital,Beijing 100044,China
authors.forename: Feng-zhan
authors.lastname: Hu
authors.affiliation: Department of Urology,Peking University People’s Hospital,Beijing 100044,China
authors.forename: Zheng-zuo
authors.initials: ZZ
authors.lastname: Sheng
authors.affiliation: Department of Urology,Peking University People’s Hospital,Beijing 100044,China
authors.forename: Cai-peng
authors.initials: CP
authors.lastname: Qin
authors.affiliation: Department of Urology,Peking University People’s Hospital,Beijing 100044,China
authors.forename: Tao
authors.initials: T
authors.lastname: Xu
mesh_terms: D002471:Cell Transformation, Neoplastic; D018925:Chemokines / Q000235:genetics / Q000502:physiology*; D015536:Down-Regulation; D006801:Humans; D007963:Leukocytes, Mononuclear; D062792:MARVEL Domain-Containing Proteins / Q000235:genetics / Q000502:physiology*; D008297:Male; D009369:Neoplasms / Q000473:pathology*
chemical_list: C515016:CMTM3 protein, human; D018925:Chemokines; D062792:MARVEL Domain-Containing Proteins