title: One year in review 2016: systemic lupus erythematosus.
abstract: Systemic lupus erythematosus (SLE) is a systemic autoimmune disease with a highly variable course and prognosis. The management of the disease is still a clinical challenge for the treating physicians as many aspects regarding the disease pathogenesis, clinical picture and outcomes remain to be elucidated. New and interesting data are emerging; here the recent literature on SLE pathogenesis, clinical and laboratory aspects, as well as treatments and comorbidities, are reviewed and the main findings summarised in order to provide a bird's eye on the relevant papers on these topics.
authors.affiliation: Department of Rheumatology, Policlinico Le Scotte, University of Siena, Italy. antonella.adinolfi986@gmail.com.
authors.forename: Antonella
authors.initials: A
authors.lastname: Adinolfi
authors.affiliation: Rheumatology Unit, University of Perugia, Italy.
authors.forename: Eleonora
authors.initials: E
authors.lastname: Valentini
authors.affiliation: Rheumatology Unit, Department of Clinical and Experimental Medicine, University of Pisa, Italy.
authors.forename: Emanuele
authors.initials: E
authors.lastname: Calabresi
authors.affiliation: Rheumatology Unit, Department of Clinical and Experimental Medicine, University of Florence, Italy.
authors.forename: Giulia
authors.initials: G
authors.lastname: Tesei
authors.affiliation: Rheumatology Unit, Department of Clinical and Experimental Medicine, University of Pisa, Italy.
authors.forename: Viola
authors.initials: V
authors.lastname: Signorini
authors.affiliation: Rheumatology Unit, Department of Clinical and Experimental Medicine, University of Pisa; and Department of Medical Biotechnologies, University of Siena, Italy.
authors.forename: Simone
authors.initials: S
authors.lastname: Barsotti
authors.affiliation: Rheumatology Unit, Department of Clinical and Experimental Medicine, University of Pisa, Italy.
authors.forename: Chiara
authors.initials: C
authors.lastname: Tani
mesh_terms: D000818:Animals; D015551:Autoimmunity; D015415:Biomarkers / Q000378:metabolism; D015897:Comorbidity; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000175:diagnosis / Q000453:epidemiology / Q000276:immunology / Q000628:therapy; D011237:Predictive Value of Tests; D011379:Prognosis; D012307:Risk Factors
chemical_list: D015415:Biomarkers