title: Dysmyelopoietic Features and Bone Marrow Histology in 30 Cases of Primary Myelodysplastic Syndromes.
abstract: Thirty cases of primary myelodysplastic syndromes (MDS) were diagnosed according to the FAB criteria. The age ranged between 5-78 years, the median age being 38 years. Twelve (40%) patients were younger than 30 years of age. Male female ratio was 2:1. Nine cases each were diagnosed as refractory anaemia (RA) and refractory anaemia with excess of blasts (RAEB) whereas 12 were diagnosed as RAEB in transformation (RAEB-T). Significantly more RA and RAEB-T cases showed dyserythropoietic features when compared to RAEB. The frequency of dysgranulopoiesis and dysmegakaryopoiesis was similar in all 3 FAB subgroups. Abnormal localisation of immature precursors (ALIP) was present in only 36.6% of the patients and was seen in 58.3% of RAEB-T. When present it appeared to indicate a worse prognosis. Six of the 12 cases showing this finding progressed either to acute myeloblastic leukemia or from RA to RAEB or RAEB-T.
authors.affiliation: a Department of Hematology, Postgraduate Institute of Medical Education & Research, Chandigarh, India, 160012.
authors.forename: S
authors.initials: S
authors.lastname: Dash
authors.affiliation: a Department of Hematology, Postgraduate Institute of Medical Education & Research, Chandigarh, India, 160012.
authors.forename: N
authors.initials: N
authors.lastname: Varma
authors.affiliation: a Department of Hematology, Postgraduate Institute of Medical Education & Research, Chandigarh, India, 160012.
authors.forename: R
authors.initials: R
authors.lastname: Sarode
authors.affiliation: a Department of Hematology, Postgraduate Institute of Medical Education & Research, Chandigarh, India, 160012.
authors.forename: N
authors.initials: N
authors.lastname: Marwaha
keywords: Myelodysplastic syndromes; bone marrow histology; dysmyelopoietic features