title: Dynamic contrast enhanced MR imaging for evaluation of angiogenesis of hepatocellular nodules in liver cirrhosis in N-nitrosodiethylamine induced rat model.
abstract: OBJECTIVE
  To investigate whether dynamic contrast -enhanced MRI (DCE-MRI) can distinguish the type of liver nodules in a rat model with N-nitrosodiethylamine- induced cirrhosis.
  
  
  METHODS
  Liver nodules in cirrhosis were induced in 60 male Wistar rats via 0.01 % N-nitrosodiethylamine in the drinking water for 35-100 days. The nodules were divided into three groups: regenerative nodule (RN), dysplastic nodule (DN), and hepatocellular carcinoma (HCC). DCE-MRI was performed, and parameters including transfer constant (Ktrans), rate constant (Kep), extravascular extracellular space volume fraction (Ve), and initial area under the contrast concentration versus time curve (iAUC) were measured and compared.
  
  
  RESULTS
  The highest Ktransand iAUC values were seen in HCC, followed by DN and RN (all P < 0.05). The area under the receiver operating characteristic curve (AUROC) for DN and HCC were 0.738 and 0.728 for Ktransand iAUC, respectively. The AUROC for HCC were 0.850 and 0.840 for Ktransand iAUC, respectively. Ordinal logistic regression analysis showed that Ktranshad a high goodness of fit (0.970, 95 % confidence interval, 13.751-24.958).
  
  
  CONCLUSIONS
  DCE-MRI is a promising method to differentiate of liver nodules. Elevated Ktranssuggested that the nodules may be transformed into HCC.
  
  
  CONCLUSIONS
  • DCE-MRI is promising for differentiating among RN, DN, and HCC • Ktransand iAUC positively correlated with malignancy degree of liver nodules • Elevated Ktranssuggests that the nodules may be transformed into HCC.
authors.affiliation: Department of Medical Imaging, Jinling Hospital, Medical School of Nanjing University, Nanjing, Jiangsu, 210002, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Zhang
authors.affiliation: Department of Medical Imaging, Jinling Hospital, Medical School of Nanjing University, Nanjing, Jiangsu, 210002, China.
authors.forename: Hui Juan
authors.initials: HJ
authors.lastname: Chen
authors.affiliation: Department of Radiology and Biomedical Imaging, University of California, San Francisco, CA, USA.
authors.forename: Zhen J
authors.initials: ZJ
authors.lastname: Wang
authors.affiliation: Department of Medical Imaging, Jinling Hospital, Medical School of Nanjing University, Nanjing, Jiangsu, 210002, China. radiology@126.com.
authors.forename: Wei
authors.initials: W
authors.lastname: Huang
authors.affiliation: Department of Medical Imaging, Jinling Hospital, Medical School of Nanjing University, Nanjing, Jiangsu, 210002, China. kevinzhlj@163.com.
authors.forename: Long Jiang
authors.initials: LJ
authors.lastname: Zhang
mesh_terms: D000792:Angiography; D000818:Animals; D006528:Carcinoma, Hepatocellular / Q000098:blood supply* / Q000209:etiology / Q000473:pathology; D003287:Contrast Media; D004052:Diethylnitrosamine; D004195:Disease Models, Animal; D055088:Early Detection of Cancer / Q000379:methods; D006801:Humans; D008103:Liver Cirrhosis / Q000139:chemically induced / Q000150:complications* / Q000473:pathology; D008113:Liver Neoplasms / Q000098:blood supply* / Q000209:etiology / Q000473:pathology; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D009389:Neovascularization, Pathologic / Q000000981:diagnostic imaging*; D012372:ROC Curve; D051381:Rats; D017208:Rats, Wistar
chemical_list: D003287:Contrast Media; D004052:Diethylnitrosamine
keywords: Angiogenesis; Dynamic contrast -enhanced -MRI (DCE-MRI); Hepatocellular carcinoma; Hepatocellular nodules in cirrhosis; Ktrans