title: Role of dietary phenols in mitigating microglia-mediated neuroinflammation.
abstract: Chronic neuroinflammation is a pathological feature of a number of central nervous system (CNS) diseases and is mediated by sustained activation of microglial cells, the innate immune cells of the CNS. Studies have mainly focused on identifying the molecular and epigenetic mechanisms of microglial activation. This is crucial in designing therapeutic strategies for neuropathologies in which prolonged microglial activation is known to exacerbate disease condition. In recent years, increasing evidence show that naturally occurring compounds present in regular diet could function as "nutraceuticals," arresting microglial activation, and thus conferring neuroprotection. This review summarizes our understanding of the role of dietary phenolic nutraceuticals in mitigating microglia-mediated neuroinflammation. Studies show that these natural phenols inhibit key signaling pathways in activated microglia such as the NFκB, MAPK and JAK-STAT that trigger microglia-mediated inflammation in various neuropathological conditions such as injury, infection, stroke, autism and neurodegenerative diseases, i.e., Alzheimer's disease and Parkinson's disease. The anti-inflammatory and antioxidant effect exerted by these natural phenols have shown considerable success in improving disease condition in animal models of neuropathologies, and thus seem to be suitable candidates for developing therapeutic strategies.
authors.affiliation: Department of Anatomy, Yong Loo Lin School of Medicine, National University of Singapore, Blk MD10, 4 Medical Drive, Singapore, 117597, Singapore.
authors.forename: Parakalan
authors.initials: P
authors.lastname: Rangarajan
authors.affiliation: Department of Anatomy, Yong Loo Lin School of Medicine, National University of Singapore, Blk MD10, 4 Medical Drive, Singapore, 117597, Singapore.
authors.forename: Aparna
authors.initials: A
authors.lastname: Karthikeyan
authors.affiliation: Department of Anatomy, Yong Loo Lin School of Medicine, National University of Singapore, Blk MD10, 4 Medical Drive, Singapore, 117597, Singapore. antstd@nus.edu.sg.
authors.forename: S T
authors.identifier: http://orcid.org/0000-0001-9600-6789
authors.initials: ST
authors.lastname: Dheen
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000378:metabolism; D019587:Dietary Supplements; D006801:Humans; D007249:Inflammation; D017628:Microglia / Q000502:physiology*; D019636:Neurodegenerative Diseases / Q000503:physiopathology; D010636:Phenols / Q000378:metabolism*
chemical_list: D000893:Anti-Inflammatory Agents; D010636:Phenols
keywords: CNS; Curcumin; Luteolin; Microglia; Neuroinflammation; Quercetin; Resveratrol