title: Immunohistochemistry as a Practical Tool in Molecular Pathology.
abstract: BACKGROUND
  -Molecular genetics is playing an increasingly important role in patient care and pathology practice. Immunohistochemistry (IHC) is a valuable and practical tool employed by most pathologists on a regular basis.
  
  
  OBJECTIVE
  -To highlight select examples of how IHC may be used in the realm of molecular diagnostics.
  
  
  METHODS
  -Select sources on IHC relating to tumor subtyping, hereditary cancer screening, and treatment-response prediction are reviewed. These represent some of the areas in which IHC can be employed by anatomic pathologists to optimize patient care and further inform molecular testing.
  
  
  CONCLUSIONS
  -In the emerging era of personalized medicine, IHC continues to serve a valuable function, complementing and enhancing other molecular techniques.
authors.affiliation: From the Department of Pathology, Vancouver General Hospital, Vancouver, Canada.
authors.forename: Brandon S
authors.initials: BS
authors.lastname: Sheffield
mesh_terms: D014408:Biomarkers, Tumor / Q000378:metabolism; D055088:Early Detection of Cancer / Q000379:methods*; D006801:Humans; D007150:Immunohistochemistry / Q000379:methods*; D009369:Neoplasms / Q000145:classification / Q000175:diagnosis* / Q000378:metabolism; D010338:Pathology, Clinical / Q000379:methods*; D057089:Pathology, Molecular / Q000379:methods*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity
chemical_list: D014408:Biomarkers, Tumor