title: Association Between Nutritional Status, Inflammatory Condition, and Prognostic Indexes with Postoperative Complications and Clinical Outcome of Patients with Gastrointestinal Neoplasia.
abstract: The aim of this study is to describe and relate nutritional and inflammatory status and prognostic indexes with postoperative complications and clinical outcome of patients with gastrointestinal malignancies. Twenty-nine patients were evaluated; nutritional assessment was carried out by subjective and objective parameters; albumin, pre-albumin, C-reactive protein (CRP), and alpha-1-acid glycoprotein (AGP) were determined. To assess prognosis, the Glasgow scale, the Prognostic Inflammatory Nutritional Index (PINI), and CRP/albumin ratio were used; the clinical outcomes considered were hospital discharge and death. A high Subjective Global Assessment (SGA) score was associated with the occurrence of postoperative complications: 73% of the patients with postoperative complications had the highest SGA score, but only 6% of those without postoperative complications had the highest SGA score (P < 0.001). Greater occurrence of death was observed in patients with a high SGA score, low serum albumin, increased CRP, PINI > 1, and Glasgow score 2. There was a positive correlation between weight loss percentage with serum CRP levels (P = 0.002), CRP/albumin (P = 0.002), PINI (P = 0.002), and Glasgow score (P = 0.000). This study provides evidence that the assessment of the nutritional status and the use of prognostic indexes are good tools for predicting postoperative complications and clinical outcome in patients with gastrointestinal neoplasia.
authors.affiliation: a Institute of Biological Sciences, University of Pernambuco, Pernambuco, Brazil and Integral Medicine Institute Prof. Fernando Figueira , Pernambuco , Brazil.
authors.forename: Milena Damasceno de Souza
authors.initials: MD
authors.lastname: Costa
authors.affiliation: a Institute of Biological Sciences, University of Pernambuco, Pernambuco, Brazil and Integral Medicine Institute Prof. Fernando Figueira , Pernambuco , Brazil.
authors.forename: Camila Yandara Sousa
authors.initials: CY
authors.lastname: Vieira de Melo
authors.affiliation: b Integral Medicine Institute Prof. Fernando Figueira , Pernambuco , Brazil.
authors.forename: Ana Carolina Ribeiro de
authors.initials: AC
authors.lastname: Amorim
authors.affiliation: c Laboratory of Clinical Analysis of the Cardiac Emergency of Pernambuco, University of Pernambuco , Pernambuco , Brazil.
authors.forename: Dilênia de Oliveira
authors.initials: Dde O
authors.lastname: Cipriano Torres
authors.affiliation: d Institute of Biological Sciences, University of Pernambuco , Pernambuco , Brazil.
authors.forename: Ana Célia Oliveira
authors.initials: AC
authors.lastname: Dos Santos
mesh_terms: D000368:Aged; D015415:Biomarkers / Q000097:blood; D001938:Brazil / Q000453:epidemiology; D002097:C-Reactive Protein / Q000032:analysis*; D005260:Female; D005770:Gastrointestinal Neoplasms / Q000150:complications / Q000175:diagnosis / Q000276:immunology / Q000601:surgery*; D006801:Humans; D015994:Incidence; D018836:Inflammation Mediators / Q000097:blood; D008137:Longitudinal Studies; D008297:Male; D044342:Malnutrition / Q000097:blood / Q000150:complications* / Q000453:epidemiology / Q000503:physiopathology; D008875:Middle Aged; D015596:Nutrition Assessment; D009752:Nutritional Status; D011183:Postoperative Complications / Q000097:blood / Q000453:epidemiology / Q000209:etiology* / Q000503:physiopathology; D011237:Predictive Value of Tests; D015995:Prevalence; D011379:Prognosis; D012306:Risk; D012720:Severity of Illness Index; D015431:Weight Loss
chemical_list: D015415:Biomarkers; D018836:Inflammation Mediators; D002097:C-Reactive Protein