title: Efficacy of tranexamic acid in haemoptysis: A randomized, controlled pilot study.
abstract: Haemoptysis is a life threatening condition irrespective of aetiology. Tranexamic acid (TA), a potent anti-fibrinolytic agent, has been shown to control bleeding, decrease transfusion requirement in knee & hip arthroplasty, coronary artery bypass grafting and heavy menstrual bleeding. TA also has mortality benefit in bleeding from surgical and trauma patients. But the studies, regarding efficacy and safety of TA in controlling haemoptysis are conflicting.
  
  
  
  In this single blinded, prospective study, total 66 patients with sub-massive haemoptysis were randomized into treatment (T) and placebo control (C) groups. Group-T received intravenous (IV) TA in a loading dose of 1 g, followed by 1 g TA over 8 h infusion and group-C received IV 0.9% normal saline. The severity of haemoptysis was assessed by quantity, frequency and visual analogue scale (VAS) score.
  
  
  
  On day 2, frequency, quantity and VAS score of haemoptysis were 2.23 ± 2.11/day, 34.19 ± 67.0 ml and 14.72 ± 15.7 respectively in Group-T and 2.29 ± 2.0/day, 90.4 ± 79.0 ml and 31.33 ± 22.12 respectively in group-C. In group-T 16.27% patients needed intervention as compared to 38.1% in group-C (p 0.053). The mean blood transfusion (1.58 ± 0.88 & 1.67 ± 0.669 units) and hospital stay (4.14 ± 3.18 & 5.48 ± 3.26 days) was also lower in group-T as compared to group-C. Group-T had better outcomes as compared to group-C, but statistically significant only for VAS score (p 0.001). During study no adverse event of the drug was noted.
  
  
  
  TA decreases severity of haemoptysis and can be used as a bridging therapy in acute haemoptysis before definitive intervention can be under taken.
authors.affiliation: Department of Internal Medicine, PGIMER, Chandigarh, India. Electronic address: balajilb95@gmail.com.
authors.forename: Balaji Laxminarayanshetty
authors.initials: BL
authors.lastname: Bellam
authors.affiliation: Department of Internal Medicine, PGIMER, Chandigarh, India. Electronic address: drdeba_prasad@yahoo.co.in.
authors.forename: Deba Prasad
authors.initials: DP
authors.lastname: Dhibar
authors.affiliation: Department of Internal Medicine, PGIMER, Chandigarh, India. Electronic address: surivikas9479@gmail.com.
authors.forename: Vikas
authors.initials: V
authors.lastname: Suri
authors.affiliation: Department of Internal Medicine, PGIMER, Chandigarh, India. Electronic address: sharma.navneet@pgimer.edu.in.
authors.forename: Navneet
authors.initials: N
authors.lastname: Sharma
authors.affiliation: Department of Internal Medicine, PGIMER, Chandigarh, India. Electronic address: suvarma@hotmail.com.
authors.forename: Subhash Chander
authors.initials: SC
authors.lastname: Varma
authors.affiliation: Department of Pharmacology, PGIMER, Chandigarh, India. Electronic address: malhotra.samir@pgimer.edu.in.
authors.forename: Samir
authors.initials: S
authors.lastname: Malhotra
authors.affiliation: Department of Internal Medicine, PGIMER, Chandigarh, India. Electronic address: ashishbhalla2016@gmail.com.
authors.forename: Ashish
authors.initials: A
authors.lastname: Bhalla
mesh_terms: D000328:Adult; D000933:Antifibrinolytic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D001803:Blood Transfusion / Q000706:statistics & numerical data; D005260:Female; D006469:Hemoptysis / Q000188:drug therapy* / Q000473:pathology; D006760:Hospitalization; D006801:Humans; D007262:Infusions, Intravenous; D007902:Length of Stay; D008297:Male; D008875:Middle Aged; D010865:Pilot Projects; D011446:Prospective Studies; D012720:Severity of Illness Index; D016037:Single-Blind Method; D014148:Tranexamic Acid / Q000008:administration & dosage / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D000933:Antifibrinolytic Agents; D014148:Tranexamic Acid
keywords: Haemoptysis; Tranexamic acid (TA); Visual analogue scale (VAS)