title: CCL2, CCL5, IL4 and IL15 Gene Polymorphisms in Women with Gestational Diabetes Mellitus.
abstract: Gestational diabetes mellitus (GDM) is a glucose intolerance that occurs during pregnancy. Several studies suggest that inflammation contributes to pregnancy-induced insulin resistance and the development of glucose intolerance. The aim of this study is to examine the association between theCCL2,CCL5,IL4andIL15gene polymorphisms and the development of GDM. This study included 411 pregnant women who underwent a 75 g oral glucose tolerance test at 24-28 weeks of gestation. Participants were categorised into 2 groups according to results of the oral glucose tolerance test (OGTT). The GDM group included 204 pregnant women who were diagnosed with GDM. The normal glucose tolerance group included 207 pregnant women with normal values in the OGTT. To discriminate theCCL2rs1024611 and rs4586,CCL5rs2107538,IL4rs2243250,IL15rs2857261 and rs2254514 alleles, TaqMan®Pre-Designed SNP Genotyping Assays were used. GDM was significantly associated with genotypes and alleles of theCCL2rs1024611 and rs4586 polymorphisms, while there was no statistically significant association between theCCL5rs2107538,IL4rs2243250,IL15rs2857261, and rs2254514 gene polymorphisms and GDM. In a multivariate regression analysis, age and BMI before pregnancy were independent significant predictors of a higher risk of GDM, while a lower number of G allelesCCL2rs1024611 was protective against GDM. Moreover, women with the GGCCL2rs1024611 and CC rs4586 genotype tended to have lower body mass and BMI increases during pregnancy, as well as lower newborn body mass. The results of our study suggest an association betweenCCL2gene polymorphisms and GDM.
authors.affiliation: Department of Obstetrics and Gynecology, County Hospital, Zielona Góra, Poland.
authors.forename: Joanna
authors.initials: J
authors.lastname: Teler
authors.affiliation: Department of Physiology, Pomeranian Medical University, Szczecin, Poland.
authors.forename: Maciej
authors.initials: M
authors.lastname: Tarnowski
authors.affiliation: Department of Biochemistry and Medical Chemistry, Pomeranian Medical University, Szczecin, Poland.
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Safranow
authors.affiliation: Faculty of Physical Education and Health Promotion, University of Szczecin, Szczecin, Poland.
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Maciejewska
authors.affiliation: Faculty of Physical Education and Health Promotion, University of Szczecin, Szczecin, Poland.
authors.forename: Marek
authors.initials: M
authors.lastname: Sawczuk
authors.affiliation: Department of Biochemistry and Medical Chemistry, Pomeranian Medical University, Szczecin, Poland.
authors.forename: Violetta
authors.initials: V
authors.lastname: Dziedziejko
authors.affiliation: Department of Physiology, Pomeranian Medical University, Szczecin, Poland.
authors.forename: Sylwia
authors.initials: S
authors.lastname: Sluczanowska-Glabowska
authors.affiliation: Department of Physiology, Pomeranian Medical University, Szczecin, Poland.
authors.forename: Andrzej
authors.initials: A
authors.lastname: Pawlik
mesh_terms: D001724:Birth Weight / Q000235:genetics; D015992:Body Mass Index; D016022:Case-Control Studies; D018932:Chemokine CCL2 / Q000235:genetics*; D018946:Chemokine CCL5 / Q000235:genetics*; D016640:Diabetes, Gestational / Q000097:blood / Q000235:genetics*; D005260:Female; D005838:Genotype; D005951:Glucose Tolerance Test; D006801:Humans; D007231:Infant, Newborn; D019409:Interleukin-15 / Q000235:genetics*; D015847:Interleukin-4 / Q000235:genetics*; D009765:Obesity / Q000235:genetics; D020641:Polymorphism, Single Nucleotide; D011247:Pregnancy; D011248:Pregnancy Complications / Q000235:genetics; D015430:Weight Gain / Q000235:genetics
chemical_list: C111835:CCL2 protein, human; C483024:CCL5 protein, human; D018932:Chemokine CCL2; D018946:Chemokine CCL5; C569274:IL15 protein, human; C508598:IL4 protein, human; D019409:Interleukin-15; D015847:Interleukin-4