title: Electrophysiological Study on Cognitive Function in Systemic Lupus Erythematosus Patients With Previous Neuropsychiatric Involvement.
abstract: This study aimed to evaluate P300 as an electrophysiological marker of cognitive function in patients with systemic lupus erythematosus (SLE) who had previous neuropsychiatric (NPSLE) involvement and were diagnosed to have cognitive impairment by standard neuropsychological tests. Event-related potentials (ERPs) were assessed by the auditory and visual oddball paradigms. Amplitude and latency of P300 at the frontal (Fz), central (Cz), and parietal (Pz) regions were determined and compared with controls. P300 detection was performed in NPSLE patients with pre-diagnosed cognitive impairment (n = 9), matched SLE patients without previous NPSLE (non-NPSLE) (n = 9), and healthy controls (n = 15). Auditory oddball task did not show any P300 abnormality between groups. Visual oddball task revealed reduced amplitude of P300 over Fz ( P = .002) and Cz ( P = .009) electrodes in NPSLE patients compared with healthy controls and among those who had predominant memory deficit ( P = .01 at Fz). Abnormal P300 was also observed in non-NPSLE patients at Fz and Cz. Using visual oddball paradigm, abnormal P300 was found in NPSLE patients over frontal and parietal regions compared with normal controls but was not discriminative from possible subclinical disease in non-NPSLE patients. In conclusion, visual oddball paradigm was a more sensitive electrophysiological marker than auditory oddball paradigm for cognitive impairment in NPSLE patients.
authors.affiliation: 1 Department of Medicine, Queen Mary Hospital, the University of Hong Kong, Hong Kong SAR.
authors.forename: Yang
authors.initials: Y
authors.lastname: Gao
authors.affiliation: 1 Department of Medicine, Queen Mary Hospital, the University of Hong Kong, Hong Kong SAR.
authors.forename: Raymond Tak Fai
authors.initials: RTF
authors.lastname: Cheung
authors.affiliation: 1 Department of Medicine, Queen Mary Hospital, the University of Hong Kong, Hong Kong SAR.
authors.forename: Junling
authors.initials: J
authors.lastname: Gao
authors.affiliation: 2 Department of Psychology, the University of Hong Kong, Hong Kong SAR.
authors.forename: Esther Y Y
authors.initials: EYY
authors.lastname: Lau
authors.affiliation: 2 Department of Psychology, the University of Hong Kong, Hong Kong SAR.
authors.forename: Jacky Ho Yin
authors.initials: JHY
authors.lastname: Wan
authors.affiliation: 1 Department of Medicine, Queen Mary Hospital, the University of Hong Kong, Hong Kong SAR.|3 Department of Biomedical Sciences, the City University of Hong Kong, Hong Kong SAR.
authors.forename: Mo Yin
authors.initials: MY
authors.lastname: Mok
mesh_terms: D000328:Adult; D001307:Auditory Perception; D003071:Cognition; D003072:Cognition Disorders / Q000150:complications / Q000175:diagnosis* / Q000503:physiopathology*; D004569:Electroencephalography / Q000379:methods*; D018913:Event-Related Potentials, P300; D005260:Female; D006801:Humans; D020945:Lupus Vasculitis, Central Nervous System / Q000150:complications / Q000175:diagnosis / Q000503:physiopathology*; D008297:Male; D009422:Nervous System Diseases / Q000150:complications / Q000175:diagnosis / Q000503:physiopathology*; D015588:Observer Variation; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D014796:Visual Perception
keywords: P300; biomarker; cognitive dysfunction; electrophysiological studies; neuropsychiatric lupus