title: Olsalazine-Based Metal-Organic Frameworks as Biocompatible Platforms for H2 Adsorption and Drug Delivery.
abstract: The drug olsalazine (H4olz) was employed as a ligand to synthesize a new series of mesoporous metal-organic frameworks that are expanded analogues of the well-known M2(dobdc) materials (dobdc(4-) = 2,5-dioxido-1,4-benzenedicarboxylate; M-MOF-74). The M2(olz) frameworks (M = Mg, Fe, Co, Ni, and Zn) exhibit high surface areas with large hexagonal pore apertures that are approximately 27 Å in diameter. Variable temperature H2 adsorption isotherms revealed strong adsorption at the open metal sites, and in situ infrared spectroscopy experiments on Mg2(olz) and Ni2(olz) were used to determine site-specific H2 binding enthalpies. In addition to its capabilities for gas sorption, the highly biocompatible Mg2(olz) framework was also evaluated as a platform for the delivery of olsalazine and other encapsulated therapeutics. The Mg2(olz) material (86 wt % olsalazine) was shown to release the therapeutic linker through dissolution of the framework under simulated physiological conditions. Furthermore, Mg2(olz) was used to encapsulate phenethylamine (PEA), a model drug for a broad class of bioactive compounds. Under simulated physiological conditions, Mg2(olz)(PEA)2 disassembled to release PEA from the pores and olsalazine from the framework itself, demonstrating that multiple therapeutic components can be delivered together at different rates. The low toxicity, high surface areas, and coordinatively unsaturated metal sites make these M2(olz) materials promising for a range of potential applications, including drug delivery in the treatment of gastrointestinal diseases.
authors.forename: Dana J
authors.initials: DJ
authors.lastname: Levine
authors.affiliation: Materials Sciences Division, Lawrence Berkeley National Laboratory , Berkeley, California 94720, United States.
authors.forename: Tomče
authors.initials: T
authors.lastname: Runčevski
authors.affiliation: Materials Sciences Division, Lawrence Berkeley National Laboratory , Berkeley, California 94720, United States.
authors.forename: Matthew T
authors.initials: MT
authors.lastname: Kapelewski
authors.forename: Benjamin K
authors.initials: BK
authors.lastname: Keitz
authors.forename: Julia
authors.initials: J
authors.lastname: Oktawiec
authors.forename: Douglas A
authors.initials: DA
authors.lastname: Reed
authors.affiliation: Materials Sciences Division, Lawrence Berkeley National Laboratory , Berkeley, California 94720, United States.
authors.forename: Jarad A
authors.initials: JA
authors.lastname: Mason
authors.affiliation: Materials Sciences Division, Lawrence Berkeley National Laboratory , Berkeley, California 94720, United States.
authors.forename: Henry Z H
authors.initials: HZ
authors.lastname: Jiang
authors.forename: Kristen A
authors.initials: KA
authors.lastname: Colwell
authors.forename: Christina M
authors.initials: CM
authors.lastname: Legendre
authors.affiliation: Department of Physics and Astronomy, Oberlin College , Oberlin, Ohio 44074, United States.
authors.forename: Stephen A
authors.initials: SA
authors.lastname: FitzGerald
authors.affiliation: Materials Sciences Division, Lawrence Berkeley National Laboratory , Berkeley, California 94720, United States.
authors.forename: Jeffrey R
authors.initials: JR
authors.lastname: Long
mesh_terms: D000327:Adsorption; D000636:Aminosalicylic Acids / Q000737:chemistry*; D001665:Binding Sites; D001672:Biocompatible Materials / Q000737:chemistry*; D002625:Chemistry, Organic; D004337:Drug Carriers; D016503:Drug Delivery Systems; D005767:Gastrointestinal Diseases / Q000188:drug therapy; D006801:Humans; D006859:Hydrogen / Q000737:chemistry; D008024:Ligands; D000073396:Metal-Organic Frameworks; D008670:Metals / Q000737:chemistry; D009930:Organic Chemicals / Q000737:chemistry; D010627:Phenethylamines / Q000737:chemistry; D010795:Phthalic Acids; D013055:Spectrophotometry, Infrared; D013499:Surface Properties
chemical_list: C547494:1,4-benzenedicarboxylate; D000636:Aminosalicylic Acids; D001672:Biocompatible Materials; D004337:Drug Carriers; D008024:Ligands; D000073396:Metal-Organic Frameworks; D008670:Metals; D009930:Organic Chemicals; D010627:Phenethylamines; D010795:Phthalic Acids; C029261:phenethylamine; D006859:Hydrogen; C032587:olsalazine