title: Comparative evaluation of diffusion hypoxia and psychomotor skills with or without postsedation oxygenation following administration of nitrous oxide in children undergoing dental procedures: A clinical study.
abstract: BACKGROUND
  Diffusion hypoxia is the most serious potential complication associated with nitrous oxide. It occurs during the recovery period. Hence, administration of 100% oxygen is mandatory as suggested by many authors.
  
  
  OBJECTIVE
  The aim of this study is to evaluate the occurrence/nonoccurrence of diffusion hypoxia in two groups of patients undergoing routine dental treatment under nitrous oxide sedation when one group is subjected to 7 min of postsedation oxygenation and the second group of the patients is made to breathe room air for the similar period.
  
  
  METHODS
  A total of sixty patients within the age group of 7-10 years requiring invasive dental procedures were randomly divided into two groups of 30 each using chit method. In the control group, patients were administered 100% oxygen postsedation, whereas, in the study group, patients were made to breathe room air postsedation. Various parameters (pulse rate, respiratory rate, blood pressure, and oxygen saturation [SpO2]) were recorded pre- and post-operatively. Data were collected and then sent for statistical analysis.
  
  
  RESULTS
  The mean postoperative SpO2 at measurement times 1, 3, 5, and 7 min in both the groups was higher than the mean preoperative SpO2. This increase was statistically significant. No significant difference was found between the Trieger test scores.
  
  
  CONCLUSIONS
  This study proves that clinical occurrence of diffusion hypoxia is not possible while following the routine procedure of nitrous oxide sedation.
authors.affiliation: Department of Pedodontics and Preventive Dentistry, Genesis Institute of Dental Sciences and Research, Ferozepur, Punjab, India.
authors.forename: Vineet Inder Singh
authors.initials: VI
authors.lastname: Khinda
authors.affiliation: Department of Pedodontics and Preventive Dentistry, Genesis Institute of Dental Sciences and Research, Ferozepur, Punjab, India.
authors.forename: Parvesh
authors.initials: P
authors.lastname: Bhuria
authors.affiliation: Department of Periodontology and Oral Implantology, Genesis Institute of Dental Sciences and Research, Ferozepur, Punjab, India.
authors.forename: Paramjit
authors.initials: P
authors.lastname: Khinda
authors.affiliation: Department of Pedodontics and Preventive Dentistry, Genesis Institute of Dental Sciences and Research, Ferozepur, Punjab, India.
authors.forename: Shiminder
authors.initials: S
authors.lastname: Kallar
authors.affiliation: Department of Pedodontics and Preventive Dentistry, Genesis Institute of Dental Sciences and Research, Ferozepur, Punjab, India.
authors.forename: Gurlal Singh
authors.initials: GS
authors.lastname: Brar
mesh_terms: D000766:Anesthesia, Dental / Q000009:adverse effects*; D018685:Anesthetics, Inhalation / Q000009:adverse effects*; D002648:Child; D019140:Dental Care for Children / Q000009:adverse effects* / Q000379:methods; D006801:Humans; D000860:Hypoxia / Q000139:chemically induced*; D009609:Nitrous Oxide / Q000009:adverse effects*; D010102:Oxygen Inhalation Therapy / Q000379:methods*; D011597:Psychomotor Performance / Q000187:drug effects*
chemical_list: D018685:Anesthetics, Inhalation; D009609:Nitrous Oxide