title: Hemodynamics through the congenitally bicuspid aortic valve: a computational fluid dynamics comparison of opening orifice area and leaflet orientation.
abstract: A computational fluid dynamics model of a bicuspid aortic valve has been developed using idealised three-dimensional geometry. The aim was to compare how the orifice area and leaflet orientation affect the hemodynamics of a pure bicuspid valve. By applying physiologic material properties and boundary conditions, blood flow shear stresses were predicted during peak systole. A reduced orifice area altered blood velocity, the pressure drop across the valve and the wall shear stress through the valve. Bicuspid models predicted impaired blood flow similar to a stenotic valve, but the flow patterns were specific to leaflet orientation. Flow patterns developed in bicuspid aortic valves, such as helical flow, were sensitive to cusp orientation. In conclusion, the reduced opening area of a bicuspid aortic valve amplifies any impaired hemodynamics, but cusp orientation determines subsequent flow patterns which may determine the specific regions downstream from the valve most at risk of clinical complications.
authors.affiliation: 1 School of Mechanical Engineering, University of Birmingham, Birmingham, UK.|2 Mechanical Engineering, Rice University, Houston, TX, USA.
authors.forename: Sen
authors.initials: S
authors.lastname: Mei
authors.affiliation: 1 School of Mechanical Engineering, University of Birmingham, Birmingham, UK.|3 Centro de Tecnologia e Geociências, Universidade Federal de Pernambuco, Cidade Universitária Recife, Recife, Brasil.
authors.forename: Francisco S N
authors.initials: FSN
authors.lastname: de Souza Júnior
authors.affiliation: 1 School of Mechanical Engineering, University of Birmingham, Birmingham, UK.|4 Cameron (Singapore) Pte. Ltd, Singapore.
authors.forename: May Y S
authors.initials: MYS
authors.lastname: Kuan
authors.affiliation: 1 School of Mechanical Engineering, University of Birmingham, Birmingham, UK.
authors.forename: Naomi C
authors.initials: NC
authors.lastname: Green
authors.affiliation: 1 School of Mechanical Engineering, University of Birmingham, Birmingham, UK.
authors.forename: Daniel M
authors.initials: DM
authors.lastname: Espino
keywords: bicuspid aortic valve; computational fluid dynamics; congenital malformation; hemodynamics