title: Post-exposure treatment of Ebola virus disease in guinea pigs using EBOTAb, an ovine antibody-based therapeutic.
abstract: Ebola virus (EBOV) is highly pathogenic, with a predisposition to cause outbreaks in human populations accompanied by significant mortality. An ovine polyclonal antibody therapy has been developed against EBOV, named EBOTAb. When tested in the stringent guinea pig model of EBOV disease, EBOTAb has been shown to confer protection at levels of 83.3%, 50% and 33.3% when treatment was first started on days 3, 4 and 5 post-challenge, respectively. These timepoints of when EBOTAb treatment was initiated correspond to when levels of EBOV are detectable in the circulation and thus mimic when treatment would likely be initiated in human infection. The effects of EBOTAb were compared with those of a monoclonal antibody cocktail, ZMapp, when delivered on day 3 post-challenge. Results showed ZMapp to confer complete protection against lethal EBOV challenge in the guinea pig model at this timepoint. The data reported demonstrate that EBOTAb is an effective treatment against EBOV disease, even when delivered late after infection.
authors.affiliation: Public Health England, Porton Down, Salisbury, Wiltshire, SP4 0JG, UK.
authors.forename: Stuart D
authors.initials: SD
authors.lastname: Dowall
authors.affiliation: Public Health England, Porton Down, Salisbury, Wiltshire, SP4 0JG, UK.
authors.forename: Andrew
authors.initials: A
authors.lastname: Bosworth
authors.affiliation: Public Health England, Porton Down, Salisbury, Wiltshire, SP4 0JG, UK.
authors.forename: Emma
authors.initials: E
authors.lastname: Rayner
authors.affiliation: Public Health England, Porton Down, Salisbury, Wiltshire, SP4 0JG, UK.
authors.forename: Irene
authors.initials: I
authors.lastname: Taylor
authors.affiliation: MicroPharm Ltd, Station Road, Newcastle Emlyn, Dyfed, SA38 9BY, UK.
authors.forename: John
authors.initials: J
authors.lastname: Landon
authors.affiliation: MicroPharm Ltd, Station Road, Newcastle Emlyn, Dyfed, SA38 9BY, UK.
authors.forename: Ian
authors.initials: I
authors.lastname: Cameron
authors.affiliation: MicroPharm Ltd, Station Road, Newcastle Emlyn, Dyfed, SA38 9BY, UK.
authors.forename: Ruth
authors.initials: R
authors.lastname: Coxon
authors.affiliation: MicroPharm Ltd, Station Road, Newcastle Emlyn, Dyfed, SA38 9BY, UK.
authors.forename: Ibrahim
authors.initials: I
authors.lastname: Al Abdulla
authors.affiliation: Public Health England, Porton Down, Salisbury, Wiltshire, SP4 0JG, UK.
authors.forename: Victoria A
authors.initials: VA
authors.lastname: Graham
authors.affiliation: Public Health England, Porton Down, Salisbury, Wiltshire, SP4 0JG, UK.
authors.forename: Graham
authors.initials: G
authors.lastname: Hall
authors.affiliation: Public Health Agency of Canada, 1015 Arlington Street, Winnipeg, Manitoba R3E 3R2, Canada.|University of Manitoba, 745 Bannatyne Avenue, Winnipeg, Manitoba R3E 0J9, Canada.
authors.forename: Gary
authors.initials: G
authors.lastname: Kobinger
authors.affiliation: Public Health England, Porton Down, Salisbury, Wiltshire, SP4 0JG, UK.
authors.forename: Roger
authors.initials: R
authors.lastname: Hewson
authors.affiliation: Public Health England, Porton Down, Salisbury, Wiltshire, SP4 0JG, UK.
authors.forename: Miles W
authors.initials: MW
authors.lastname: Carroll
mesh_terms: D000818:Animals; D000911:Antibodies, Monoclonal / Q000097:blood / Q000627:therapeutic use; D000914:Antibodies, Viral / Q000097:blood / Q000627:therapeutic use*; D000918:Antibody Specificity / Q000276:immunology; D000956:Antigens, Viral / Q000378:metabolism; D029043:Ebolavirus / Q000235:genetics / Q000502:physiology*; D016679:Genome, Viral; D006168:Guinea Pigs; D019142:Hemorrhagic Fever, Ebola / Q000097:blood / Q000188:drug therapy* / Q000473:pathology; D008099:Liver / Q000473:pathology / Q000821:virology; D056990:Post-Exposure Prophylaxis; D012367:RNA, Viral / Q000097:blood; D012756:Sheep; D013154:Spleen / Q000473:pathology / Q000821:virology; D016019:Survival Analysis
chemical_list: D000911:Antibodies, Monoclonal; D000914:Antibodies, Viral; D000956:Antigens, Viral; D012367:RNA, Viral; C000594176:ZMapp