title: Application of Chitosan/PVA Nano fiber as a potential wound dressing for streptozotocin-induced diabetic rats.
abstract: Diabetes mellitus is a worldwide health problem affecting 1-2% of the population of world with noticeable morbidity and mortality. Vascular events such as hypertension, nephropathy, neuropathy and retinopathy are happened in diabetic patients. Decline in tissue blood circulation may causes hypoxia and finally may leads to slow wound healing and amputation. PVA/Chitosan Nano fiber wound dressings have high moisture vapor transmission rate and good antimicrobial activity1PCNWD substrate does not have any recognized cytotoxicity effects and has excellent odor absorbing capability. In the present study, Streptozotocin (STZ) is used to induce diabetes in rats, Skin ulcers are produced experimentally in the experimentally induced diabetic and non-diabetic rats. Then PCNWD used as wound dressing for 2 weeks period to evaluate its macroscopic and microscopic effects on wound healing in comparison with untreated diabetic and non-diabetic rats experimental ulcers. The findings of current study indicate significant acceleration in diabetes wound healing on the rats treated by PVA/Chitosan Nano fiber.
authors: University of Isfahan, Iran. Electronic address: saeedmajd68@gmail.com.
authors: Saeed
authors: S
authors: Ahmadi Majd
authors: University of Isfahan, Iran. Electronic address: m.rabbani@biol.ui.ac.ir.
authors: Mohammad
authors: M
authors: Rabbani Khorasgani
authors: University of Isfahan, Iran. Electronic address: jamalmoshtaghian@gmail.com.
authors: Seyed Jamal
authors: SJ
authors: Moshtaghian
authors: School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran. Electronic address: talebi@med.mui.ac.ir.
authors: Ardeshir
authors: A
authors: Talebi
authors: University of Isfahan, Iran. Electronic address: Maryam_kh6811@yahoo.com.
authors: Maryam
authors: M
authors: Khezri
mesh_terms: D000279:Administration, Cutaneous; D000818:Animals; D047070:Bandages, Hydrocolloid; D001692:Biological Transport; D048271:Chitosan / Q000737:chemistry / Q000494:pharmacology*; D003921:Diabetes Mellitus, Experimental / Q000139:chemically induced / Q000150:complications / Q000628:therapy*; D057139:Nanofibers / Q000008:administration & dosage* / Q000737:chemistry; D011142:Polyvinyl Alcohol / Q000737:chemistry / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D012883:Skin Ulcer / Q000139:chemically induced / Q000150:complications / Q000628:therapy*; D013311:Streptozocin; D014867:Water / Q000378:metabolism
chemical_list: D014867:Water; D013311:Streptozocin; D011142:Polyvinyl Alcohol; D048271:Chitosan
keywords: Chitosan/PVA Nano fiber; Diabetes; Rat; Streptozotocin; Wound dressing