title: Simultaneous cytosolic delivery of a chemotherapeutic and siRNA using nanoparticle-stabilized nanocapsules.
abstract: We report on nanoparticle-stabilized capsules (NPSCs) as a platform for the co-delivery of survivin-targeted siRNA and tamoxifen. These capsules feature an inner oil core that provides a carrier for tamoxifen, and is coated on the surface with positively charged nanoparticles self-assembled with siRNA. The multifaceted chemical nature of the NPSC system enables the simultaneous delivery of both payloads directly into the cytosol in vitro. The NPSC co-delivery of tamoxifen and survivin-targeted siRNA into breast cancer cells disables the pathways that inhibit apoptosis, resulting in enhanced breast cell death.
authors: Joseph
authors: J
authors: Hardie
authors: Ying
authors: Y
authors: Jiang
authors: Emily R
authors: ER
authors: Tetrault
authors: Phaedra C
authors: PC
authors: Ghazi
authors: Gulen Yesilbag
authors: GY
authors: Tonga
authors: Michelle E
authors: ME
authors: Farkas
authors: Vincent M
authors: VM
authors: Rotello
mesh_terms: D003600:Cytosol; D051034:Inhibitor of Apoptosis Proteins; D053769:Nanocapsules; D053758:Nanoparticles; D034741:RNA, Small Interfering
chemical_list: D051034:Inhibitor of Apoptosis Proteins; D053769:Nanocapsules; D034741:RNA, Small Interfering