title: Vitamin D status and its relationship with bone mineral density in a healthy Iranian population.
abstract: OBJECTIVE
  Considering the controversial results regarding the relationship between vitamin D levels and bone mineral density in different populations, the present study was designed to evaluate this correlation in a healthy Iranian population.
  
  
  METHODS
  Using a random cluster sample of apparently healthy men and women, this multicenter cross-sectional study was carried out among 4450 individuals living in urban areas of five major cities in Iran. Bone mineral density (BMD) values at different sites were analyzed along with the serum levels of 25(OH)D and PTH. Analysis of variance (ANOVA) was used to estimate the main effects, through comparing the mean values of these markers based on the bone mineral density status of the study group in each sex.
  
  
  RESULTS
  25(OH)D levels were inversely correlated with BMD values at total hip (r = -0.062 in men and r = -0.057 in women) and spine (r = -0.076 in men and r = -0.107 in women). After adjusting the data for age, the inverse correlation was no longer statistically significant.
  
  
  CONCLUSIONS
  Serum 25(OH)D levels are inversely correlated with bone mass values in both sexes.
authors: Osteoporosis Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran; Center for Microsystems Technology (CMST), Ghent University, Ghent, Belgium.
authors: Patricia
authors: P
authors: Khashayar
authors: Osteoporosis Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.
authors: Hamid Reza
authors: HR
authors: Aghaei Meybodi
authors: Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.
authors: Mohsen
authors: M
authors: Rezai Hemami
authors: Department of Health, The Ministry of Health and Medical Education (MOHME), Tehran, Iran; Department of Nutrition, The Ministry of Health and Medical Education (MOHME), Tehran, Iran.
authors: Abbasali
authors: A
authors: Keshtkar
authors: Department of Internal Medicine, Division of Endocrinology and Metabolism, Medical University of Graz, Graz, Austria.
authors: Hans Peter
authors: HP
authors: Dimai
authors: Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.
authors: Bagher
authors: B
authors: Larijani
keywords: Biological markers; Bone mineral density; Calcium; Osteoporosis; Phosphorus; Vitamin D