title: Predicted 25-hydroxyvitamin D in relation to incidence of breast cancer in a large cohort of African American women.
abstract: Vitamin D deficiency, which has been linked to an increased risk of colorectal cancer, is particularly common among African Americans. Previous studies of vitamin D status and breast cancer risk, mostly conducted in white women, have had conflicting results. We examined the relationship between predicted vitamin D status and incidence of breast cancer in a cohort of 59,000 African American women.
  
  
  
  Participants in the Black Women's Health Study have been followed by biennial mail questionnaires since 1995, with self-reported diagnoses of cancer confirmed by hospital and cancer registry records. Repeated five-fold cross-validation with linear regression was used to derive the best 25-hydroxyvitamin D (25(OH)D) prediction model based on measured 25(OH)D in plasma specimens obtained from 2856 participants in 2013-2015 and questionnaire-based variables from the same time frame. In the full cohort, including 1454 cases of incident invasive breast cancer, Cox proportional hazards models were used to compute the incidence rate ratio (IRR) for each quartile of predicted vitamin D score relative to the highest quartile. Predicted vitamin D score for each two-year exposure period was a cumulative average of predicted scores from all exposure periods up to that time.
  
  
  
  Twenty-two percent of women with measured 25(OH)D were categorized as "deficient" (<20 ng/mL) and another 25 % as "insufficient" (20-29 ng/mL). The prediction model explained 25 % of variation in measured 25(OH)D and the correlation coefficient for predicted versus observed 25(OH)D averaged across all cross-validation runs was 0.49 (SD 0.026). Breast cancer risk increased with decreasing quartile of predicted 25(OH)D, p for trend 0.015; the IRR for the lowest versus highest quartile was 1.23 (95 % confidence interval 1.04, 1.46).
  
  
  
  In prospective data, African American women in the lowest quartile of cumulative predicted 25(OH)D were estimated to have a 23 % increased risk of breast cancer relative to those with relatively high levels. Preventing vitamin D deficiency may be an effective means of reducing breast cancer incidence in African American women.
authors: Slone Epidemiology Center at Boston University, 1010 Commonwealth Avenue, 4th floor, Boston, MA, 02215, USA. jpalmer@bu.edu.
authors: Julie R
authors: JR
authors: Palmer
authors: Slone Epidemiology Center at Boston University, 1010 Commonwealth Avenue, 4th floor, Boston, MA, 02215, USA.|Department of Biostatistics, Boston University School of Public Health, Boston, MA, 02118, USA.
authors: Hanna
authors: H
authors: Gerlovin
authors: Slone Epidemiology Center at Boston University, 1010 Commonwealth Avenue, 4th floor, Boston, MA, 02215, USA.
authors: Traci N
authors: TN
authors: Bethea
authors: Slone Epidemiology Center at Boston University, 1010 Commonwealth Avenue, 4th floor, Boston, MA, 02215, USA.
authors: Kimberly A
authors: KA
authors: Bertrand
authors: Department of Medicine, Physiology and Biophysics, Boston University School of Medicine, Boston, MA, 02118, USA.
authors: Michael F
authors: MF
authors: Holick
authors: Slone Epidemiology Center at Boston University, 1010 Commonwealth Avenue, 4th floor, Boston, MA, 02215, USA.
authors: Edward N
authors: EN
authors: Ruiz-Narvaez
authors: Department of Epidemiology, Boston University School of Public Health, Boston, MA, 02118, USA.
authors: Lauren A
authors: LA
authors: Wise
authors: Slone Epidemiology Center at Boston University, 1010 Commonwealth Avenue, 4th floor, Boston, MA, 02215, USA.
authors: Stephen A
authors: SA
authors: Haddad
authors: Georgetown University Lombardi Cancer Center, Washington, DC, 20057, USA.
authors: Lucile L
authors: LL
authors: Adams-Campbell
authors: Quest Diagnostics, Inc, Madison, NJ, 07940, USA.
authors: Harvey W
authors: HW
authors: Kaufman
authors: Slone Epidemiology Center at Boston University, 1010 Commonwealth Avenue, 4th floor, Boston, MA, 02215, USA.
authors: Lynn
authors: L
authors: Rosenberg
authors: Slone Epidemiology Center at Boston University, 1010 Commonwealth Avenue, 4th floor, Boston, MA, 02215, USA.
authors: Yvette C
authors: YC
authors: Cozier
mesh_terms: D000328:Adult; D001741:Black or African American; D000368:Aged; D001943:Breast Neoplasms / Q000097:blood* / Q000453:epidemiology*; D005260:Female; D006801:Humans; D015994:Incidence; D008875:Middle Aged; D011159:Population Surveillance; D012189:Retrospective Studies; D011795:Surveys and Questionnaires; D014481:United States / Q000453:epidemiology / Q000208:ethnology; D014807:Vitamin D / Q000031:analogs & derivatives* / Q000097:blood; D055815:Young Adult
chemical_list: D014807:Vitamin D; C104450:25-hydroxyvitamin D
keywords: African American; Breast cancer; Prediction models; Vitamin D