title: Dual targeting of Hsp90 in childhood acute lymphoblastic leukaemia.
authors: Bristol Institute for Transfusion Sciences, Bristol, UK.|School of Cellular and Molecular Medicine, University of Bristol, Bristol, UK.
authors: Paraskevi
authors: P
authors: Diamanti
authors: Bristol Institute for Transfusion Sciences, Bristol, UK.|School of Cellular and Molecular Medicine, University of Bristol, Bristol, UK.
authors: Charlotte V
authors: CV
authors: Cox
authors: Bristol Royal Hospital for Children, Bristol, UK.
authors: John P
authors: JP
authors: Moppett
authors: Bristol Institute for Transfusion Sciences, Bristol, UK.|School of Cellular and Molecular Medicine, University of Bristol, Bristol, UK.
authors: Allison
authors: A
authors: Blair
mesh_terms: D000970:Antineoplastic Agents / Q000494:pharmacology / Q000627:therapeutic use; D016227:Benzoquinones / Q000494:pharmacology; D002470:Cell Survival / Q000187:drug effects; D002648:Child; D004305:Dose-Response Relationship, Drug; D018841:HSP90 Heat-Shock Proteins / Q000037:antagonists & inhibitors / Q000378:metabolism*; D006801:Humans; D047029:Lactams, Macrocyclic / Q000494:pharmacology; D058990:Molecular Targeted Therapy; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy / Q000378:metabolism*; D015398:Signal Transduction / Q000187:drug effects
chemical_list: D000970:Antineoplastic Agents; D016227:Benzoquinones; D018841:HSP90 Heat-Shock Proteins; D047029:Lactams, Macrocyclic; C448659:17-(dimethylaminoethylamino)-17-demethoxygeldanamycin
keywords: Hsp90; NSG mice; acute lymphoblastic leukaemia; leukaemia-initiating cells; toxicity