title: Blood granulocyte patterns as predictors of asthma phenotypes in adults from the EGEA study.
abstract: To what extent blood granulocyte patterns may predict asthma control remains under-studied. Our aim was to study associations between blood neutrophilia and eosinophilia and asthma control outcomes in adults.Analyses were conducted in 474 asthmatics from the first follow-up of the Epidemiological Study on the Genetics and Environment of Asthma (EGEA2), including 242 asthmatics who were adults a decade earlier (EGEA1). At EGEA2, asthma control was assessed using the Global Initiative for Asthma definition (2015), and asthma exacerbations by use of urgent care or courses of oral corticosteroids in the past year. Blood EOSlo/EOShiwas defined as </≥250 eosinophils·mm-3, respectively, and NEUlo/NEUhias </≥5000 neutrophils·mm-3, respectively. Estimates were adjusted for age, sex and smoking.At EGEA2, NEUhiwas associated with asthma exacerbations and poor asthma control (OR >2.10). EOShiwas associated with higher bronchial hyperresponsiveness (BHR) (OR (95% CI) 2.21 (1.24-3.97)), poor lung function (p=0.02) and higher total IgE level (p=0.002). Almost 50% of asthmatics had a persistent pattern between surveys. Persistent NEUhiwas associated with poor asthma control at EGEA2 (OR (95% CI) 3.09 (1.18-7.05)). EOShiat EGEA1 and persistent EOShiwere associated with higher BHR (OR (95% CI) 2.36 (1.10-5.07) and 3.85 (1.11-13.34), respectively), poor lung function (p<0.06) and higher immunoglobulin E level (p<10-4) at EGEA2.Granulocyte patterns were differently associated with asthma outcomes, suggesting specific roles for each one, which could be tested as predictive signatures.
authors: INSERM, U1168, VIMA: Ageing and Chronic Diseases, Epidemiological and Public Health Approaches, Villejuif, France Univ Versailles St-Quentin-en-Yvelines, UMR-S 1168, Montigny le Bretonneux, France rachel.nadif@inserm.fr.
authors: Rachel
authors: R
authors: Nadif
authors: INSERM, IAB, Team of Environmental Epidemiology Applied to Reproduction and Respiratory Health, Grenoble, France Univ Grenoble Alpes, Grenoble, France CHU de Grenoble, Pédiatrie, Grenoble, France.
authors: Valérie
authors: V
authors: Siroux
authors: INSERM, IAB, Team of Environmental Epidemiology Applied to Reproduction and Respiratory Health, Grenoble, France Univ Grenoble Alpes, Grenoble, France CHU de Grenoble, Pédiatrie, Grenoble, France.
authors: Anne
authors: A
authors: Boudier
authors: INSERM, U1168, VIMA: Ageing and Chronic Diseases, Epidemiological and Public Health Approaches, Villejuif, France Univ Versailles St-Quentin-en-Yvelines, UMR-S 1168, Montigny le Bretonneux, France.
authors: Nicole
authors: N
authors: le Moual
authors: Centre de l'Asthme et des Allergies, APHP, Hôpital Trousseau, UMPC Paris 6, Paris, France.
authors: Jocelyne
authors: J
authors: Just
authors: CHU de Lyon, Pneumology Dept, Lyon, France.
authors: Frederic
authors: F
authors: Gormand
authors: Clinique Universitaire de Pneumologie, Pôle Thorax et Vaisseaux, CHU Grenoble, Grenoble, France INSERM U1055, Grenoble, France Univ Grenoble Alpes, Grenoble, France.
authors: Christophe
authors: C
authors: Pison
authors: Univ Lille, Lille, France CHU, Lille, France.
authors: Regis
authors: R
authors: Matran
authors: INSERM, IAB, Team of Environmental Epidemiology Applied to Reproduction and Respiratory Health, Grenoble, France Univ Grenoble Alpes, Grenoble, France CHU de Grenoble, Pédiatrie, Grenoble, France.
authors: Isabelle
authors: I
authors: Pin
mesh_terms: D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000328:Adult; D001249:Asthma / Q000097:blood* / Q000503:physiopathology*; D015992:Body Mass Index; D016535:Bronchial Hyperreactivity / Q000235:genetics; D015331:Cohort Studies; D003430:Cross-Sectional Studies; D004804:Eosinophils / Q000166:cytology; D005260:Female; D006098:Granulocytes / Q000166:cytology*; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood; D007958:Leukocyte Count; D008297:Male; D008875:Middle Aged; D009504:Neutrophils / Q000166:cytology; D010641:Phenotype; D012907:Smoking; D016896:Treatment Outcome
chemical_list: D000305:Adrenal Cortex Hormones; D007073:Immunoglobulin E