title: Two-Dimensional Supramolecular Polymers Embodying Large Unilamellar Vesicles in Water.
abstract: We hereby describe a strategy for obtaining novel topological nanostructures consisting of dual-cavity basket 1, forming a curved monolayer of large unilamellar vesicles in water (CAC < 0.25 μM), and bivalent guests 4/5 populating the cavities of such bolaamphiphilic hosts. On the basis of the results of (1)H NMR spectroscopy, electron microscopy, and dynamic light scattering measurements, we postulated that divalent guest molecules 4/5 cover the curved vesicular surface in a lateral fashion to satisfy the complexation [2 + 2] valency and thereby give stable two-dimensional supramolecular polymers [1⊂4]n and [1⊂5]n. The results of experimental studies are also supported with coarse-grained molecular dynamics simulations and molecular mechanics. Our discovery about the assembly of novel vesicular structures could be of interest for stabilization/functionalization of liposomal surfaces as well as detection of polyvalent molecules and removal of targeted substances from aqueous environments.
authors: Department of Chemistry and Biochemistry, The Ohio State University , 100 West 18th Avenue, Columbus, Ohio 43210, United States.
authors: Shigui
authors: S
authors: Chen
authors: Department of Chemistry and Biochemistry, The Ohio State University , 100 West 18th Avenue, Columbus, Ohio 43210, United States.
authors: Shane M
authors: SM
authors: Polen
authors: Department of Chemistry and Biochemistry, The Ohio State University , 100 West 18th Avenue, Columbus, Ohio 43210, United States.
authors: Lu
authors: L
authors: Wang
authors: Department of Chemistry and Biochemistry, The Ohio State University , 100 West 18th Avenue, Columbus, Ohio 43210, United States.
authors: Makoto
authors: M
authors: Yamasaki
authors: Department of Chemistry and Biochemistry, The Ohio State University , 100 West 18th Avenue, Columbus, Ohio 43210, United States.
authors: Christopher M
authors: CM
authors: Hadad
authors: Department of Chemistry and Biochemistry, The Ohio State University , 100 West 18th Avenue, Columbus, Ohio 43210, United States.
authors: Jovica D
authors: JD
authors: Badjić