title: Studying the General Toxicity and Cumulative Properties of a Radiopharmaceutical Nanocolloid, (99m)Tc-Al2O3.
abstract: We studied toxicity of a new Russian radiopharmaceutical Nanocolloid, (99m)Tc-Al2O3. Tests for acute toxicity showed that this agent belongs to a class of moderate-toxicity substances and does not have cumulative properties. The evaluation of subchronic toxicity after subcutaneous injection of this product to rats (0.04, 0.2, and 0.4 ml/kg) and rabbits (0.02 and 0.2 ml/kg) for 7 days did not reveal changes in the general state, temperature, body weight, indices of the peripheral blood and bone marrow, functions of the heart, liver, kidneys, and nervous system, and morphological characteristics of the internal organs in animals. The drug does not produce a local irritant effect.
authors: Laboratory No. 3, Physicotechnical Institute, Tomsk Polytechnic University, Tomsk, Russia. varlamova@tpu.ru.
authors: N V
authors: NV
authors: Varlamova
authors: Laboratory of Drug Toxicology, E. D. Goldberg Research, Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia.
authors: A A
authors: AA
authors: Churin
authors: Laboratory of Drug Toxicology, E. D. Goldberg Research, Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia.
authors: T I
authors: TI
authors: Fomina
authors: Laboratory of Drug Toxicology, E. D. Goldberg Research, Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia.
authors: L A
authors: LA
authors: Ermolaeva
authors: Laboratory of Drug Toxicology, E. D. Goldberg Research, Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia.
authors: T V
authors: TV
authors: Vetoshkina
authors: Laboratory of Drug Toxicology, E. D. Goldberg Research, Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia.
authors: T Yu
authors: TY
authors: Dubskaya
authors: Laboratory of Drug Toxicology, E. D. Goldberg Research, Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia.
authors: T Yu
authors: TY
authors: Lamzina
authors: Laboratory of Drug Toxicology, E. D. Goldberg Research, Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia.
authors: E P
authors: EP
authors: Fedorova
authors: Laboratory of Drug Toxicology, E. D. Goldberg Research, Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia.
authors: O V
authors: OV
authors: Neupokoeva
authors: Laboratory No. 3, Physicotechnical Institute, Tomsk Polytechnic University, Tomsk, Russia.
authors: V S
authors: VS
authors: Skuridin
authors: Laboratory No. 3, Physicotechnical Institute, Tomsk Polytechnic University, Tomsk, Russia.
authors: E A
authors: EA
authors: Nesterov
authors: Laboratory No. 3, Physicotechnical Institute, Tomsk Polytechnic University, Tomsk, Russia.
authors: L A
authors: LA
authors: Larionova
authors: Laboratory No. 3, Physicotechnical Institute, Tomsk Polytechnic University, Tomsk, Russia.|Laboratory for Radionuclide Methods of Study, Tomsk Research Institute of Oncology, Tomsk, Russia.
authors: V I
authors: VI
authors: Chernov
mesh_terms: D000537:Aluminum Oxide / Q000009:adverse effects; D000818:Animals; D001831:Body Temperature / Q000187:drug effects; D005260:Female; D006321:Heart / Q000187:drug effects; D007668:Kidney / Q000187:drug effects; D008099:Liver / Q000187:drug effects; D008297:Male; D051379:Mice; D053758:Nanoparticles / Q000009:adverse effects; D009420:Nervous System / Q000187:drug effects; D011817:Rabbits; D019275:Radiopharmaceuticals / Q000009:adverse effects*; D051381:Rats; D013667:Technetium / Q000009:adverse effects
chemical_list: D019275:Radiopharmaceuticals; D013667:Technetium; D000537:Aluminum Oxide
keywords: acute toxicity; cumulation; preclinical trials; radiopharmaceutical; subchronic toxicity