title: The methylome and transcriptome of fetal skin: implications for scarless healing.
abstract: Fetal skin is known to heal without scarring. In mice, the phenomenon is observed until the 16-17 day of gestation - the day of transition from scarless to normal healing. The study aims to identify key methylome and transcriptome changes following the transition.
  
  
  
  Methylome and transcriptome profiles were analyzed in murine dorsal skin using microarray approach.
  
  
  
  The genes associated with inflammatory response and hyaluronate degradation showed increased DNA methylation before the transition, while those involved in embryonic morphogenesis, neuron differentiation and synapse functions did so after. A number of the methylome alterations were retained until adulthood and correlated with gene expression, while the functional associations imply that scarless healing depends on epigenetic regulation.
authors: Department of Molecular Biotechnology & Microbiology, Gdańsk University of Technology, Gdańsk, Poland.|Department of Biology & Pharmaceutical Botany, Medical University of Gdańsk, Gdańsk, Poland.|Tri-City Academic Laboratory Animal Centre - Research & Services Centre, Medical University of Gdańsk, Gdańsk, Poland.
authors: Justyna
authors: J
authors: Podolak-Popinigis
authors: Department of Molecular Biotechnology & Microbiology, Gdańsk University of Technology, Gdańsk, Poland.|Department of Biology & Pharmaceutical Botany, Medical University of Gdańsk, Gdańsk, Poland.|Tri-City Academic Laboratory Animal Centre - Research & Services Centre, Medical University of Gdańsk, Gdańsk, Poland.
authors: Anna
authors: A
authors: Ronowicz
authors: Department of Molecular Biotechnology & Microbiology, Gdańsk University of Technology, Gdańsk, Poland.|Department of Biology & Pharmaceutical Botany, Medical University of Gdańsk, Gdańsk, Poland.|Tri-City Academic Laboratory Animal Centre - Research & Services Centre, Medical University of Gdańsk, Gdańsk, Poland.
authors: Monika
authors: M
authors: Dmochowska
authors: Department of Molecular Biotechnology & Microbiology, Gdańsk University of Technology, Gdańsk, Poland.|Department of Biology & Pharmaceutical Botany, Medical University of Gdańsk, Gdańsk, Poland.|Tri-City Academic Laboratory Animal Centre - Research & Services Centre, Medical University of Gdańsk, Gdańsk, Poland.
authors: Agnieszka
authors: A
authors: Jakubiak
authors: Department of Molecular Biotechnology & Microbiology, Gdańsk University of Technology, Gdańsk, Poland.|Department of Biology & Pharmaceutical Botany, Medical University of Gdańsk, Gdańsk, Poland.|Tri-City Academic Laboratory Animal Centre - Research & Services Centre, Medical University of Gdańsk, Gdańsk, Poland.
authors: Paweł
authors: P
authors: Sachadyn
mesh_terms: D000818:Animals; D002921:Cicatrix / Q000235:genetics; D019175:DNA Methylation; D044127:Epigenesis, Genetic; D005260:Female; D005333:Fetus; D008810:Mice, Inbred C57BL; D011247:Pregnancy; D049188:Prenatal Injuries / Q000235:genetics*; D012867:Skin / Q000293:injuries / Q000378:metabolism*; D059467:Transcriptome; D014945:Wound Healing / Q000235:genetics*
keywords: fetal skin; genome-wide DNA methylation profiling; genome-wide gene expression profiling; scarless skin wound healing