title: Mx oligomer: a novel capsid pattern sensor?
abstract: Myxovirus resistance proteins represent a family of interferon-induced restriction factors of the innate and adaptive immune system. Human MxB acts as a novel restriction factor with antiviral activity against a range of HIV-1 and other retroviruses mainly by inhibiting the uncoating process after reverse transcription but prior to integration. Based on published data and conservation analysis, we propose a novel hypothesis, in which MxB dimers form higher order oligomers that restrict retroviral replication by binding to the viral capsid. Insights into the mechanistic basis of structural and functional characteristics of MxB will greatly advance our understanding of MxB.
authors: School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China.|School of Life Sciences, Tianjin University, Tianjin 300072, China.|State Key Laboratory of Medicinal Chemical Biology, NanKai University, Tianjin 300071, China.
authors: Jia
authors: J
authors: Kong
authors: School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China.|School of Life Sciences, Tianjin University, Tianjin 300072, China.|State Key Laboratory of Medicinal Chemical Biology, NanKai University, Tianjin 300071, China.
authors: Min
authors: M
authors: Ma
authors: School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China.|School of Life Sciences, Tianjin University, Tianjin 300072, China.|State Key Laboratory of Medicinal Chemical Biology, NanKai University, Tianjin 300071, China.
authors: Shuangyi
authors: S
authors: He
authors: School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China.|School of Life Sciences, Tianjin University, Tianjin 300072, China.|State Key Laboratory of Medicinal Chemical Biology, NanKai University, Tianjin 300071, China.
authors: Xiaohong
authors: X
authors: Qin
mesh_terms: D000595:Amino Acid Sequence; D002213:Capsid / Q000276:immunology*; D015658:HIV Infections / Q000235:genetics / Q000276:immunology* / Q000821:virology; D015497:HIV-1 / Q000235:genetics / Q000276:immunology*; D054884:Host-Pathogen Interactions; D006801:Humans; D008969:Molecular Sequence Data; D064547:Myxovirus Resistance Proteins / Q000737:chemistry* / Q000235:genetics / Q000276:immunology*; D016415:Sequence Alignment
chemical_list: C579068:MX2 protein, human; D064547:Myxovirus Resistance Proteins
keywords: HIV-1; MxB; NLS; capsid; oligomerization; restriction factor