title: Chiral Ligands for Rhodium-Catalyzed Asymmetric Hydroformylation: A Personal Account.
abstract: Asymmetric hydroformylation represents one of the most efficient routes for the preparation of chiral aldehydes from alkenes in the presence of syngas in a perfect atom-economic way. During the past few decades, a variety of chiral ligands have been developed for the asymmetric hydroformylation. However, only a few ligands exhibit good performance in terms of the regio- and enantioselectivities. Additionally, for the chiral ligands developed up to now, only limited substrates were tolerated and no examples have led to the application of the asymmetric hydroformylation reaction on a commercial scale due to several technical challenges. This account provides a brief introduction of the current efficient chiral ligands for asymmetric hydroformylation and the ongoing efforts we have made in this field.
authors: College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, Hubei 430072, P. R. China.
authors: Caiyou
authors: C
authors: Chen
authors: College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, Hubei 430072, P. R. China.
authors: Xiu-Qin
authors: XQ
authors: Dong
authors: College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, Hubei 430072, P. R. China.|Department of Chemistry, South University of Science and Technology of China, Shenzhen 518000, P. R. China.
authors: Xumu
authors: X
authors: Zhang
keywords:  P ligands;  hydroformylation;  hydrogenation;  ligand design; asymmetric catalysis