title: Relationship between primary restless legs syndrome and migraine with aura.
abstract: In this study, the prevalence and characteristics of definite migraine in primary restless legs syndrome (pRLS) patients and matched control patients (CPs) were investigated. We evaluated 63 consecutive adult pRLS patients and 141 age- and sex-matched controls in this case-control study. The diagnosis of migraine and its subtypes were defined based on The International Classification of Headache Disorders-II. Only those with "definite" migraine were included in the study. The mean age of 63 adult pRLS patients (15 men and 48 women) who participated in the study was 49.4 years. A total of 27 patients (42.9%) had definite migraine. Of these migraineurs, seven (11.1%) were without aura and 20 (31.8%) were with aura. The mean age of the 141 matched CPs was 48.7 years. A total of 32 CPs (22.7%) experienced migraine. Among these 32 migraineurs, 28 (19.9%) were without aura and four (2.8%) were with aura. Migraine and migraine with aura were significantly more common in pRLS patients than in CPs. pRLS patients with migraine were more anxious and experienced a shorter duration of RLS symptoms than pRLS patients without migraine. Migraineurs in the pRLS group tended to have high scores for severity of migraine headache by Visual Analog Scale score and high levels of disability by Migraine Disability Assessment grading than those in the control group. pRLS patients showed a positive association with definite migraine headaches. In contrast to results highlighted in recent studies, we found a strong link between migraine with aura and pRLS.
authors: Department of Neurology, Sakarya University Faculty of Medicine, Sakarya, Turkey. Electronic address: bilgehanacar@hotmail.com.
authors: Bilgehan Atılgan
authors: BA
authors: Acar
authors: Department of Neurology, Sakarya University Education and Research Hospital, Sakarya, Turkey.
authors: Türkan
authors: T
authors: Acar
authors: Department of Neurology, Sakarya University Faculty of Medicine, Sakarya, Turkey.
authors: Aybala Neslihan
authors: AN
authors: Alagöz
authors: Department of Radiology, Sakarya University Faculty of Medicine, Sakarya, Turkey.
authors: Alper
authors: A
authors: Karacan
authors: Department of Internal Medicine, Sakarya University Faculty of Medicine, Sakarya, Turkey.
authors: Ceyhun
authors: C
authors: Varım
authors: Department of Internal Medicine, Division of Hematology, Sakarya University Education and Research Hospital, Sakarya, Turkey.
authors: Mehmet Şevki
authors: MŞ
authors: Uyanık
authors: Department of Internal Medicine, Sakarya University Faculty of Medicine, Sakarya, Turkey.
authors: Tezcan
authors: T
authors: Kaya
authors: Department of Cardiology, Sakarya University Faculty of Medicine, Sakarya, Turkey.
authors: Ramazan
authors: R
authors: Akdemir
mesh_terms: D003710:Demography; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D020325:Migraine with Aura / Q000150:complications* / Q000453:epidemiology; D010147:Pain Measurement; D015995:Prevalence; D012148:Restless Legs Syndrome / Q000150:complications*; D012890:Sleep
keywords: Aura; Migraine; Primary restless legs syndrome