title: The Leicester cerebral haemodynamics database: normative values and the influence of age and sex.
abstract: Normative values of physiological parameters hold significance in modern day clinical decision-making. Lack of such normative values has been a major hurdle in the translation of research into clinical practice. A large database containing uniform recordings was constructed to allow more robust estimates of normative ranges and also assess the influence of age and sex. Doppler recordings were performed on healthy volunteers in the same laboratory, using similar protocols and equipment. Beat-to-beat blood pressure, heart-rate, electrocardiogram, and end-tidal CO2 were measured continuously. Bilateral insonation of the middle cerebral arteries (MCAs) was performed using TCD following a 15 min stabilisation, and a 5 min baseline recording. Good quality Doppler recordings for both MCAs were obtained in 129 participants (57 female) with a median age of 57 years (range 20-82). Age was found to influence baseline haemodynamic and transfer function analysis parameters. Cerebral blood flow velocity and critical closing pressure were the only sex-related differences found, which was significantly higher in females than males. Normative values for cerebral haemodynamic parameters have been defined in a large, healthy population. Such age/sex-defined normal values can be used to reduce the burden of collecting additional control data in future studies, as well as to identify disease-associated changes.
authors: Department of Cardiovascular Sciences, Cerebral Haemodynamics in Ageing and Stroke Medicine Research Group, University of Leicester, Leicester, LE2 7LX, UK. NIHR Biomedical Research Unit for Cardiovascular Sciences, University of Leicester, Leicester, UK.
authors: Nikil
authors: N
authors: Patel
authors: Ronney B
authors: RB
authors: Panerai
authors: Victoria
authors: V
authors: Haunton
authors: Emmanuel
authors: E
authors: Katsogridakis
authors: Nazia P
authors: NP
authors: Saeed
authors: Angela
authors: A
authors: Salinet
authors: Fiona
authors: F
authors: Brodie
authors: Nazia
authors: N
authors: Syed
authors: Schnell
authors: S
authors: D'Sa
authors: Thompson G
authors: TG
authors: Robinson
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000502:physiology*; D001921:Brain / Q000098:blood supply* / Q000502:physiology; D016208:Databases, Factual; D005260:Female; D006439:Hemodynamics; D006801:Humans; D008297:Male; D008875:Middle Aged; D012727:Sex Characteristics; D055815:Young Adult