title: Anti cytokine therapy in chronic inflammatory arthritis.
abstract: This is a review looking at anti cytokine therapy in Rheumatoid Arthritis (RA), Psoriatic Arthritis (PSA) and Ankylosing Spondylitis (AS). The review explores the similarities and differences in the clinical features, as well as treatments and cytokines involved in the development and propagation of the disease. Particular attention is paid to TNFα inhibitors IL-1ra, IL-6 and JAK kinase Inhibitors, anti IL23 and IL-12 and the new developments with anti-IL-17.
authors: Department of Rheumatology, Institute of Infection and Immunity, Cardiff University School of Medicine, Tenovus Building, Heath Park Campus, Cardiff CF14 4XN, United Kingdom. Electronic address: rawlingscr@cardiff.ac.uk.
authors: Charlotte
authors: C
authors: Thompson
authors: Department of Rheumatology, Institute of Infection and Immunity, Cardiff University School of Medicine, Tenovus Building, Heath Park Campus, Cardiff CF14 4XN, United Kingdom.
authors: Ruth
authors: R
authors: Davies
authors: Department of Rheumatology and Translational Research, Institute of Infection and Immunity, Director of Arthritis Research UKCREATE Centre and Welsh Arthritis Research Network (WARN), Cardiff University School of Medicine, Tenovus Building, Heath Park Campus, Cardiff CF14 4XN, United Kingdom. Electronic address: ChoyEH@Cardiff.ac.uk.
authors: Ernest
authors: E
authors: Choy
mesh_terms: D000818:Animals; D015535:Arthritis, Psoriatic / Q000188:drug therapy* / Q000276:immunology / Q000503:physiopathology; D001172:Arthritis, Rheumatoid / Q000188:drug therapy* / Q000276:immunology / Q000503:physiopathology; D002908:Chronic Disease / Q000188:drug therapy; D016207:Cytokines / Q000037:antagonists & inhibitors* / Q000378:metabolism; D006801:Humans; D053590:Interleukin 1 Receptor Antagonist Protein / Q000627:therapeutic use; D018664:Interleukin-12 / Q000037:antagonists & inhibitors; D020381:Interleukin-17 / Q000037:antagonists & inhibitors; D053759:Interleukin-23 / Q000037:antagonists & inhibitors; D064094:Interleukin-27 / Q000037:antagonists & inhibitors; D015850:Interleukin-6 / Q000627:therapeutic use; D053612:Janus Kinases / Q000037:antagonists & inhibitors; D051379:Mice; D013167:Spondylitis, Ankylosing / Q000188:drug therapy* / Q000276:immunology / Q000503:physiopathology; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors
chemical_list: D016207:Cytokines; C508600:IL6 protein, human; D053590:Interleukin 1 Receptor Antagonist Protein; D020381:Interleukin-17; D053759:Interleukin-23; D064094:Interleukin-27; D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha; D018664:Interleukin-12; D053612:Janus Kinases
keywords: Ankylosing Spondylitis; Cytokine; IL27; Inflammatory arthritis; Psoriatic Arthritis; Rheumatoid Arthritis; TNFα inhibitor