title: Association between prematurity and the evolution of psychotic disorders in 22q11.2 deletion syndrome.
abstract: In this study, we report the developmental, physical and psychiatric manifestations of 22q11.2 deletion syndrome (22q11.2DS) in a large Israeli cohort, and search for a possible association between preterm birth and the risk for psychotic disorders. The study population consisted of 128 individuals with 22q11.2DS (77 male, 51 female), aged 1-55 years (mean ± SD 12.9 ± 11.0). All subjects underwent a comprehensive medical evaluation. All subjects older than 5 years (n = 104) were also evaluated psychiatrically. Overall, we found rates of physical manifestations similar to those previously reported in the literature. Psychiatric disorders were very common among our study population, with psychotic disorders occurring in 16.3 % of the psychiatrically evaluated population. We found an association between the presence of psychotic disorders and preterm birth. Our results replicate and extend the findings of a previous work and suggest that the evolution of psychosis in 22q11.2DS is a neurodevelopmental process with early obstetric and medical precursors.
authors: The Child Psychiatry Unit, Edmond and Lily Safra Children's Hospital, Sheba Medical Center, 5262000, Tel Hashomer, Israel.
authors: Yael
authors: Y
authors: Midbari Kufert
authors: The Center of Cleft Palate and Craniofacial Anomalies, Meir Medical Center, Kfar Saba, Israel.|The Communication Disorders Faculty, Hadassah Academic College, Jerusalem, Israel.
authors: Ariela
authors: A
authors: Nachmani
authors: Beer Yaakov-Ness Ziona Mental Health Center, Beer Yaakov, Israel.
authors: Einat
authors: E
authors: Nativ
authors: Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.|Geha Mental Health Center, Petah Tikva, Israel.|Felsenstein Medical Research Center, Petah Tikva, Israel.
authors: Abraham
authors: A
authors: Weizman
authors: The Child Psychiatry Unit, Edmond and Lily Safra Children's Hospital, Sheba Medical Center, 5262000, Tel Hashomer, Israel. gothelf@post.tau.ac.il.|Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel. gothelf@post.tau.ac.il.
authors: Doron
authors: D
authors: Gothelf
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D004062:DiGeorge Syndrome / Q000150:complications*; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D008875:Middle Aged; D009460:Neurologic Examination; D011569:Psychiatric Status Rating Scales; D011618:Psychotic Disorders / Q000175:diagnosis / Q000209:etiology*; D018709:Statistics, Nonparametric; D055815:Young Adult
keywords: Gestational age; Prematurity; Psychosis; Schizophrenia; Velocardiofacial syndrome