title: New sesquiterpene lactones from Ambrosia cumanensis Kunth.
abstract: Eleven sesquiterpene lactones, including three new natural products (1-3), were isolated from the n-butanolic extract of Ambrosia cumanensis Kunth. aerial parts. The structure of all isolated compounds was elucidated by 1D- and 2D-NMR, and MS analyses. All compounds were tested for their antiproliferative activity on HeLa, Jurkat, and U937 cell lines. Compound 3, 2,3-dehydropsilostachyn C, showed cytotoxic activity with different potency in all cell lines. By means of flow cytometric studies, compound 3 was demonstrated to induce in Jurkat cells a G2/M cell cycle block, while in U937 elicited both cytostatic and cytotoxic responses.
authors: Grupo de Investigacion en Sustancias Bioactivas, Facultad de Ciencias Farmaceuticas y Alimentarias, Universidad de Antioquia UdeA, Calle 70 No. 52-21, Medellin, Colombia.
authors: Nora Del Socorro
authors: Ndel S
authors: Jimenez-Usuga
authors: Dipartimento di Farmacia, Università di Salerno, Via Giovanni Paolo II, 84084 Fisciano, Salerno, Italy.
authors: Nicola
authors: N
authors: Malafronte
authors: Dipartimento di Farmacia, Università di Salerno, Via Giovanni Paolo II, 84084 Fisciano, Salerno, Italy.
authors: Roberta
authors: R
authors: Cotugno
authors: Dipartimento di Farmacia, Università di Pisa, Pisa, Via Bonanno 33, 56126 Pisa, Italy.
authors: Marinella
authors: M
authors: De Leo
authors: Grupo de Investigacion en Sustancias Bioactivas, Facultad de Ciencias Farmaceuticas y Alimentarias, Universidad de Antioquia UdeA, Calle 70 No. 52-21, Medellin, Colombia.
authors: Edison
authors: E
authors: Osorio
authors: Dipartimento di Farmacia, Università di Salerno, Via Giovanni Paolo II, 84084 Fisciano, Salerno, Italy. Electronic address: detommasi@unisa.it.
authors: Nunziatina
authors: N
authors: De Tommasi
mesh_terms: D031164:Ambrosia / Q000737:chemistry*; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000302:isolation & purification; D006367:HeLa Cells; D006801:Humans; D019169:Jurkat Cells; D007783:Lactones / Q000737:chemistry* / Q000302:isolation & purification; D015394:Molecular Structure; D035261:Plant Components, Aerial / Q000737:chemistry; D010936:Plant Extracts / Q000737:chemistry; D012717:Sesquiterpenes / Q000737:chemistry* / Q000302:isolation & purification; D020298:U937 Cells
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D007783:Lactones; D010936:Plant Extracts; D012717:Sesquiterpenes
keywords: Ambrosia cumanensis; Asteraceae; Cytotoxic activity; Sesquiterpene lactones