title: Intestinal Epithelial Cell Response to Clostridium difficile Flagella.
abstract: Clostridium difficile is the bacterium responsible for most antibiotic-associated diarrhea in North America and Europe. This bacterium, which colonizes the gut of humans and animals, produces toxins that are known to contribute directly to damage of the gut. It is known that bacterial flagella are involved in intestinal lesions through the inflammatory host response. The C. difficile flagellin recognizes TLR5 and consequently activates the NF-κB and the MAPK signaling pathways which elicit the synthesis of pro-inflammatory cytokines. Increasing interest on the role of C. difficile flagella in eliciting this cell response was recently developed and the development of tools to study cell response triggered by C. difficile flagella will improve our understanding of the pathogenesis of C. difficile.
authors: Unité Bactéries Pathogènes et Santé (UBaPS), Faculté de Pharmacie, Université Paris-Sud, Université Paris-Saclay, 92296, Châtenay-Malabry, France.
authors: Jameel
authors: J
authors: Batah
authors: Unité Bactéries Pathogènes et Santé (UBaPS), Faculté de Pharmacie, Université Paris-Sud, Université Paris-Saclay, 92296, Châtenay-Malabry, France. imad.kansau@u-psud.fr.
authors: Imad
authors: I
authors: Kansau
mesh_terms: D001426:Bacterial Proteins / Q000235:genetics / Q000276:immunology / Q000494:pharmacology*; D018938:Caco-2 Cells; D002232:Carbocyanines / Q000737:chemistry; D002470:Cell Survival / Q000187:drug effects; D016360:Clostridioides difficile / Q000737:chemistry / Q000235:genetics / Q000276:immunology*; D016207:Cytokines / Q000096:biosynthesis / Q000276:immunology*; D005407:Flagella / Q000737:chemistry / Q000276:immunology*; D005408:Flagellin / Q000235:genetics / Q000276:immunology / Q000494:pharmacology*; D005786:Gene Expression Regulation; D006639:Histidine / Q000235:genetics / Q000378:metabolism; D054884:Host-Pathogen Interactions; D006801:Humans; D007113:Immunity, Innate; D020928:Mitogen-Activated Protein Kinases / Q000235:genetics / Q000276:immunology; D016328:NF-kappa B / Q000235:genetics / Q000276:immunology; D009842:Oligopeptides / Q000235:genetics / Q000378:metabolism; D040081:Protein Array Analysis; D011993:Recombinant Fusion Proteins / Q000235:genetics / Q000276:immunology / Q000494:pharmacology; D015398:Signal Transduction; D019809:Streptavidin / Q000737:chemistry; D051198:Toll-Like Receptor 5 / Q000235:genetics / Q000276:immunology
chemical_list: D001426:Bacterial Proteins; D002232:Carbocyanines; D016207:Cytokines; C471213:His-His-His-His-His-His; D016328:NF-kappa B; D009842:Oligopeptides; D011993:Recombinant Fusion Proteins; C495346:TLR5 protein, human; D051198:Toll-Like Receptor 5; C089187:cyanine dye 3; D005408:Flagellin; D006639:Histidine; D019809:Streptavidin; D020928:Mitogen-Activated Protein Kinases
keywords: Clostridium difficile flagella; Flagellin FliC; Innate immune response; MAPK; NF-κB; TLR5 signaling