title: Hostile takeover: Manipulation of HIF-1 signaling in pathogen-associated cancers (Review).
abstract: Hypoxia-inducible factor (HIF)-1 is a central regulator in the adaptation process of cell response to hypoxia (low oxygen). Emerging evidence has demonstrated that HIF-1 plays an important role in the development and progression of many types of human diseases, including pathogen-associated cancers. In the present review, we summarize the recent understandings of how human pathogenic agents including viruses, bacteria and parasites deregulate cellular HIF-1 signaling pathway in their associated cancer cells, and highlight the common molecular mechanisms of HIF-1 signaling activated by these pathogenic infection, which could act as potential diagnostic markers and new therapeutic strategies against human infectious cancers.
authors: Key Laboratory of Medical Molecular Virology (Ministries of Education and Health), School of Basic Medical Sciences, Fudan University, Shanghai 200032, P.R. China.
authors: Caixia
authors: C
authors: Zhu
authors: Key Laboratory of Medical Molecular Virology (Ministries of Education and Health), School of Basic Medical Sciences, Fudan University, Shanghai 200032, P.R. China.
authors: Qing
authors: Q
authors: Zhu
authors: Key Laboratory of Medical Molecular Virology (Ministries of Education and Health), School of Basic Medical Sciences, Fudan University, Shanghai 200032, P.R. China.
authors: Chong
authors: C
authors: Wang
authors: Key Laboratory of Medical Molecular Virology (Ministries of Education and Health), School of Basic Medical Sciences, Fudan University, Shanghai 200032, P.R. China.
authors: Liming
authors: L
authors: Zhang
authors: ShengYushou Center of Cell Biology and Immunology, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, P.R. China.
authors: Fang
authors: F
authors: Wei
authors: Key Laboratory of Medical Molecular Virology (Ministries of Education and Health), School of Basic Medical Sciences, Fudan University, Shanghai 200032, P.R. China.
authors: Qiliang
authors: Q
authors: Cai
mesh_terms: D000818:Animals; D018407:Bacterial Physiological Phenomena; D014408:Biomarkers, Tumor / Q000378:metabolism; D015687:Cell Hypoxia; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D051795:Hypoxia-Inducible Factor 1, alpha Subunit / Q000235:genetics* / Q000378:metabolism*; D007501:Iron / Q000378:metabolism; D009369:Neoplasms / Q000235:genetics / Q000378:metabolism / Q000382:microbiology* / Q000469:parasitology*; D018384:Oxidative Stress; D010271:Parasites / Q000502:physiology; D015398:Signal Transduction; D015533:Transcriptional Activation; D018406:Virus Physiological Phenomena
chemical_list: D014408:Biomarkers, Tumor; C497442:HIF1A protein, human; D051795:Hypoxia-Inducible Factor 1, alpha Subunit; D007501:Iron