title: The fabrication of well-interconnected polycaprolactone/hydroxyapatite composite scaffolds, enhancing the exposure of hydroxyapatite using the wire-network molding technique.
abstract: In this study, the fabrication method was proposed for the well-interconnected polycaprolactone/hydroxyapatite composite scaffold with exposed hydroxyapatite using modified WNM technique. To characterize well-interconnected scaffolds in terms of hydroxyapatite exposure, several assessments were performed as follows: morphology, mechanical property, wettability, calcium ion release, and cell response assessments. The results of these assessments were compared with those of control scaffolds which were fabricated by precision extruding deposition (PED) apparatus. The control PED scaffolds have interconnected pores with nonexposed hydroxyapatite. Consequently, cell attachment of proposed WNM scaffold was improved by increased hydrophilicity and surface roughness of scaffold surface resulting from the exposure of hydroxyapatite particles and fabrication process using powders. Moreover, cell proliferation and differentiation of WNM scaffold were increased, because the exposure of hydroxyapatite particles may enhance cell adhesion and calcium ion release. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 105B: 2315-2325, 2017.
authors: Division of Mechanical and Automotive Engineering, College of Engineering, Wonkwang University, 460 Iksandae-ro, Iksan, Jeonbuk, 570-749, Republic of Korea.
authors: Yong Sang
authors: YS
authors: Cho
authors: Department of Orthopedic surgery, Daejeon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, 64, Daeheungro, Jung-gu, Daejeon, 301-723, Republic of korea.
authors: Myoung Wha
authors: MW
authors: Hong
authors: Division of Mechanical and Automotive Engineering, College of Engineering, Wonkwang University, 460 Iksandae-ro, Iksan, Jeonbuk, 570-749, Republic of Korea.
authors: Hoon-Jin
authors: HJ
authors: Jeong
authors: Division of Mechanical and Automotive Engineering, College of Engineering, Wonkwang University, 460 Iksandae-ro, Iksan, Jeonbuk, 570-749, Republic of Korea.
authors: Seung-Jae
authors: SJ
authors: Lee
authors: Department of Orthopedic surgery, Daejeon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, 64, Daeheungro, Jung-gu, Daejeon, 301-723, Republic of korea.
authors: Young Yul
authors: YY
authors: Kim
authors: Division of Mechanical and Automotive Engineering, College of Engineering, Wonkwang University, 460 Iksandae-ro, Iksan, Jeonbuk, 570-749, Republic of Korea.
authors: Young-Sam
authors: YS
authors: Cho
mesh_terms: D002448:Cell Adhesion; D002460:Cell Line; D049109:Cell Proliferation; D017886:Durapatite / Q000737:chemistry*; D006801:Humans; D008422:Materials Testing; D011091:Polyesters / Q000737:chemistry*; D054457:Tissue Scaffolds / Q000737:chemistry*
chemical_list: D011091:Polyesters; C016240:polycaprolactone; D017886:Durapatite
keywords: HA (hydroxyapatite); PCL (polycaprolactone); WNM (wire-network molding); bone tissue engineering; scaffold