title: Haemopedia: An Expression Atlas of Murine Hematopoietic Cells.
abstract: Hematopoiesis is a multistage process involving the differentiation of stem and progenitor cells into distinct mature cell lineages. Here we present Haemopedia, an atlas of murine gene-expression data containing 54 hematopoietic cell types, covering all the mature lineages in hematopoiesis. We include rare cell populations such as eosinophils, mast cells, basophils, and megakaryocytes, and a broad collection of progenitor and stem cells. We show that lineage branching and maturation during hematopoiesis can be reconstructed using the expression patterns of small sets of genes. We also have identified genes with enriched expression in each of the mature blood cell lineages, many of which show conserved lineage-enriched expression in human hematopoiesis. We have created an online web portal called Haemosphere to make analyses of Haemopedia and other blood cell transcriptional datasets easier. This resource provides simple tools to interrogate gene-expression-based relationships between hematopoietic cell types and genes of interest.
authors: Molecular Medicine Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australia; Department of Medical Biology, University of Melbourne, Parkville, VIC 3010, Australia. Electronic address: degraaf@wehi.edu.au.
authors: Carolyn A
authors: CA
authors: de Graaf
authors: Molecular Medicine Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australia; Department of Medical Biology, University of Melbourne, Parkville, VIC 3010, Australia.
authors: Jarny
authors: J
authors: Choi
authors: Molecular Medicine Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australia.
authors: Tracey M
authors: TM
authors: Baldwin
authors: Molecular Medicine Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australia; Department of Medical Biology, University of Melbourne, Parkville, VIC 3010, Australia.
authors: Jessica E
authors: JE
authors: Bolden
authors: Molecular Medicine Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australia; Department of Medical Biology, University of Melbourne, Parkville, VIC 3010, Australia.
authors: Kirsten A
authors: KA
authors: Fairfax
authors: Molecular Medicine Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australia; Department of Medical Biology, University of Melbourne, Parkville, VIC 3010, Australia.
authors: Aaron J
authors: AJ
authors: Robinson
authors: Molecular Medicine Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australia; Department of Medical Biology, University of Melbourne, Parkville, VIC 3010, Australia.
authors: Christine
authors: C
authors: Biben
authors: Molecular Medicine Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australia; Department of Medical Biology, University of Melbourne, Parkville, VIC 3010, Australia.
authors: Clare
authors: C
authors: Morgan
authors: Molecular Medicine Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australia.
authors: Kerry
authors: K
authors: Ramsay
authors: Cancer and Haematology Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australia; Department of Medical Biology, University of Melbourne, Parkville, VIC 3010, Australia.
authors: Ashley P
authors: AP
authors: Ng
authors: Cancer and Haematology Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australia; Department of Medical Biology, University of Melbourne, Parkville, VIC 3010, Australia.
authors: Maria
authors: M
authors: Kauppi
authors: Molecular Medicine Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australia; Department of Medical Biology, University of Melbourne, Parkville, VIC 3010, Australia.
authors: Elizabeth A
authors: EA
authors: Kruse
authors: Molecular Medicine Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australia; Department of Medical Biology, University of Melbourne, Parkville, VIC 3010, Australia.
authors: Tobias J
authors: TJ
authors: Sargeant
authors: Molecular Medicine Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australia.
authors: Nick
authors: N
authors: Seidenman
authors: Molecular Immunology Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australia.
authors: Angela
authors: A
authors: D'Amico
authors: Molecular Medicine Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australia; CSL Limited, Parkville, VIC 3052, Australia.
authors: Marthe C
authors: MC
authors: D'Ombrain
authors: Molecular Medicine Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australia.
authors: Erin C
authors: EC
authors: Lucas
authors: CSL Limited, Parkville, VIC 3052, Australia.
authors: Sandra
authors: S
authors: Koernig
authors: CSL Limited, Parkville, VIC 3052, Australia.
authors: Adriana
authors: A
authors: Baz Morelli
authors: CSL Limited, Parkville, VIC 3052, Australia.
authors: Michael J
authors: MJ
authors: Wilson
authors: CSL Limited, Parkville, VIC 3052, Australia.
authors: Steven K
authors: SK
authors: Dower
authors: Biomedical Manufacturing, CSIRO Manufacturing, Clayton, VIC 3169, Australia; Australian Regenerative Medicine Institute, Monash University, Clayton, VIC 3800, Australia.
authors: Brenda
authors: B
authors: Williams
authors: Biomedical Manufacturing, CSIRO Manufacturing, Clayton, VIC 3169, Australia; Australian Regenerative Medicine Institute, Monash University, Clayton, VIC 3800, Australia.
authors: Shen Y
authors: SY
authors: Heazlewood
authors: Bioinformatics Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3010, Australia.
authors: Yifang
authors: Y
authors: Hu
authors: Biomedical Manufacturing, CSIRO Manufacturing, Clayton, VIC 3169, Australia; Australian Regenerative Medicine Institute, Monash University, Clayton, VIC 3800, Australia.
authors: Susan K
authors: SK
authors: Nilsson
authors: Molecular Immunology Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australia; Tsinghua University School of Medicine, Beijing 100084, China.
authors: Li
authors: L
authors: Wu
authors: Bioinformatics Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3010, Australia; Department of Mathematics and Statistics, University of Melbourne, Parkville, VIC 3052, Australia.
authors: Gordon K
authors: GK
authors: Smyth
authors: Cancer and Haematology Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australia; Department of Medical Biology, University of Melbourne, Parkville, VIC 3010, Australia.
authors: Warren S
authors: WS
authors: Alexander
authors: Molecular Medicine Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australia; Department of Medical Biology, University of Melbourne, Parkville, VIC 3010, Australia.
authors: Douglas J
authors: DJ
authors: Hilton
mesh_terms: D000818:Animals; D001773:Blood Cells / Q000166:cytology* / Q000378:metabolism*; D002454:Cell Differentiation / Q000235:genetics; D019070:Cell Lineage / Q000235:genetics; D016000:Cluster Analysis; D019295:Computational Biology / Q000379:methods; D020869:Gene Expression Profiling; D018507:Gene Expression Regulation, Developmental; D006410:Hematopoiesis / Q000235:genetics*; D006801:Humans; D051379:Mice; D064878:Web Browser