title: [Distal Pancreatectomy with Autologous Fibrin Sealant - Implementation of an Established Concept of Tissue Sealing in Pancreatic Surgery].
abstract: Background:Postoperative pancreatic fistulas (POPF) remain a major concern after distal pancreatectomy. Irrespective of the technique to close the pancreatic remnant, pancreatic fistulas will occur in approximately 30 % of patients undergoing distal pancreatectomy. For the first time ever, autologous fibrin sealant (Vivostat®) was used to additionally seal the pancreatic remnant after a distal pancreatectomy. The aim was to analyse whether this changes the postoperative outcome.Patients/Material and Methods:In 2015, a technical case series was performed in 15 patients who underwent distal pancreatectomy. The pancreatic remnant was additionally sealed with autologous fibrin sealant (Vivostat®).Results:A postoperative pancreatic fistula (POPF) occurred in 5/15 patients (33 %). One patient had a POPF grade A (1/15, 6.7 %), whereas a POPF grade B occurred in 4/15 patients (26.7 %). 75 % (3/4) of the patients with a POPF grade B were sufficiently treated with antibiotics, whereas a CT-guided percutaneous drainage had to be placed only in one case.Conclusion:Autologous fibrin sealant is simple to apply and seems to be well tolerated. However, it does not seem to avoid the development of postoperative pancreatic fistulas after distal pancreatectomy.
authors: Klinik für Allgemein- und Viszeralchirurgie, Katholisches Klinikum Bochum - St. Josef-Hospital, Deutschland.
authors: A M
authors: AM
authors: Luu
authors: Klinik für Allgemein- und Viszeralchirurgie, Katholisches Klinikum Bochum - St. Josef-Hospital, Deutschland.
authors: C
authors: C
authors: Braumann
authors: Klinik für Allgemein- und Viszeralchirurgie, Katholisches Klinikum Bochum - St. Josef-Hospital, Deutschland.
authors: O
authors: O
authors: Belyaev
authors: Klinik für Allgemein- und Viszeralchirurgie, Katholisches Klinikum Bochum - St. Josef-Hospital, Deutschland.
authors: M
authors: M
authors: Janot
authors: Klinik für Allgemein- und Viszeralchirurgie, Katholisches Klinikum Bochum - St. Josef-Hospital, Deutschland.
authors: W
authors: W
authors: Uhl
authors: Klinik für Allgemein- und Viszeralchirurgie, Katholisches Klinikum Bochum - St. Josef-Hospital, Deutschland.
authors: T
authors: T
authors: Herzog
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D015718:Fibrin Tissue Adhesive / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010180:Pancreatectomy / Q000379:methods*; D010185:Pancreatic Fistula / Q000145:classification / Q000517:prevention & control* / Q000628:therapy; D010190:Pancreatic Neoplasms / Q000556:secondary* / Q000601:surgery*; D050500:Pancreatitis, Chronic / Q000601:surgery*; D011183:Postoperative Complications / Q000517:prevention & control*; D016896:Treatment Outcome
chemical_list: D015718:Fibrin Tissue Adhesive