title: In-vitro anticancer activity of green synthesized silver nanoparticles on MCF-7 human breast cancer cells.
abstract: In recent years, green synthesis of metallic nanoparticles is a growing area of research because of their potential applications in nanomedicine. In the present study we synthesized silver nanoparticles (silver NPs) from AgNO3 using aqueous extract of Lonicera hypoglauca flower as reducing and capping agents. The synthesized silver NPs were characterized using UV-Vis spectroscopy, FTIR, SEM-ED, TEM and SAED. Silver NPs were found to be significantly toxic to MCF-7 cells via the induction of apoptosis whereas sparing normal immune system (RAW 264.7) cells.
authors: Department of Physiology, College of Korean Medicine, Dongguk University, Gyeongju 780-714, South Korea.
authors: Suk Ju
authors: SJ
authors: Jang
authors: Department of Physiology, College of Korean Medicine, Dongguk University, Gyeongju 780-714, South Korea.
authors: In Jun
authors: IJ
authors: Yang
authors: Department of Physiology, College of Korean Medicine, Dongguk University, Gyeongju 780-714, South Korea.
authors: Clement O
authors: CO
authors: Tettey
authors: Korean Medicine (KM)-Based Herbal Drug Development Group, Herbal Medicine Research Division, Korea Institute of Oriental Medicine (KIOM), 1672 Yuseong-daero, Yuseong-gu, Daejeon 305-811, South Korea.
authors: Ki Mo
authors: KM
authors: Kim
authors: Department of Physiology, College of Korean Medicine, Dongguk University, Gyeongju 780-714, South Korea; Korea Promotion Institute for Traditional Medicine Industry, Gyeongsan, Gyeongbuk 712-210, South Korea. Electronic address: heungmuk@gmail.com.
authors: Heung Mook
authors: HM
authors: Shin
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D005260:Female; D006801:Humans; D031239:Lonicera / Q000737:chemistry*; D061986:MCF-7 Cells; D053768:Metal Nanoparticles / Q000737:chemistry*; D010936:Plant Extracts / Q000737:chemistry*; D012834:Silver / Q000737:chemistry / Q000494:pharmacology
chemical_list: D000970:Antineoplastic Agents; D010936:Plant Extracts; D012834:Silver
keywords: Anticancer; Green synthesis; Lonicera hypoglauca; MCF-7; Silver NPs