title: Association between angiotensin converting enzyme gene insertion/deletion polymorphism and renal scar risk in children vesicoureteral reflex: a reappraise meta-analysis.
abstract: Vesicoureteral reflex(VUR) is a common disease in children. Some studies indicated that the angiotensin converting enzyme (ACE) gene insertion/deletion (I/D) polymorphism associated with the renal scar in VUR, but not all researchers agreed with it. To clarify the effect of ACE I/D polymorphism on renal scar risk in children with VUR, we performed the present meta-analysis. PubMed, CNKI, CBM, and Embase databases were searched for studies that examined the relationship between ACE I/D polymorphism and renal scar risk in children with VUR. The Stata 12.0 software was used for statistical analyses. 11 case-control studies with 1,032 VUR patients were analyzed. The results showed that the DD genotype and D allele were associated with renal scar risk in overall VUR patients, DD vs. DI + II: OR = 1.61, 95% CI = 1.04-2.49, P = 0.03; DD vs. II: OR = 1.78, 95% CI = 1.20-2.65, P < 0.01; D vs. I: OR = 1.38, 95% CI = 1.02-1.86, P = 0.04. Similar results were revealed in Turks, but not in Caucasians and Asians. Our meta-analysis indicated that the ACE DD genotype may increase the risk of renal scar in children with VUR.
authors: Evidence-Based Medicine Center, Xiangyang Hospital, Hubei University of Medicine, Xiangyang 441000, P.R. China.
authors: Jin-Wei
authors: JW
authors: Ai
authors: Department of Urology, Zhongnan Hospital of Wuhan University, Wuhan 430071, P.R. China.|Center for Evidence-Based Medicine and Translational Medicine, Zhongnan Hospital of Wuhan University, Wuhan 430071, P.R. China.|Center for Evidence-Based Medicine and Translational Medicine, Wuhan University, Wuhan 430071, P.R. China.
authors: Xian-Tao
authors: XT
authors: Zeng
authors: Evidence-Based Medicine Center, Xiangyang Hospital, Hubei University of Medicine, Xiangyang 441000, P.R. China.
authors: Ying
authors: Y
authors: Liu
authors: Department of Pediatrics, Shiyan People's Hospital, Hubei University of Medicine, Shiyan 442000, P.R. China.
authors: Yu
authors: Y
authors: Fu
authors: Department of Urology, Zhongnan Hospital of Wuhan University, Wuhan 430071, P.R. China.
authors: Tong-Zu
authors: TZ
authors: Liu
authors: Evidence-Based Medicine Center, Xiangyang Hospital, Hubei University of Medicine, Xiangyang 441000, P.R. China.
authors: Bin
authors: B
authors: Pei
mesh_terms: D000483:Alleles; D016022:Case-Control Studies; D002921:Cicatrix / Q000235:genetics*; D005006:Ethnicity; D005838:Genotype; D006801:Humans; D054643:INDEL Mutation; D007674:Kidney Diseases / Q000235:genetics*; D016017:Odds Ratio; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D012306:Risk; D014718:Vesico-Ureteral Reflux / Q000235:genetics*
chemical_list: D007703:Peptidyl-Dipeptidase A