title: Resveratrol counteracts lipopolysaccharide-induced depressive-like behaviors via enhanced hippocampal neurogenesis.
abstract: Radial glial-like cells (RGLs) in the adult dentate gyrus (DG) function as progenitor cells for adult hippocampal neurogenesis, a process involved in the stress-related pathophysiology and treatment efficiency of depression. Resveratrol (RSV) has been demonstrated to be a potent activator of neurogenesis. The present study investigated whether chronic RSV treatment has antidepressant potential in relation to hippocampal neurogenesis. Mice received two weeks of RSV (20 mg/kg) or dimethylsulfoxide (DMSO) treatment, followed by lipopolysaccharide (LPS; 1 mg/kg) or saline injections for 5 days. We found that RSV treatment abrogated the increased immobility in the forced swimming test and tail suspension test induced by LPS. Immunohistochemical staining revealed that RSV treatment reversed the increase in microglial activation and the inhibition in DG neurogenesis. RSV treatment also attenuated LPS-induced defects in the expanding of RGLs through promoting symmetric division. In addition, RSV ameliorated LPS-induced NF-κB activation in the hippocampus coincides with the up-regulation levels of Sirt1 and Hes1. Taken together, these data indicated that RSV-induced Sirt1 activation counteracts LPS-induced depression-like behaviors via a neurogenic mechanism. A new model to understand the role of RSV in treating depression may result from these findings.
authors: Department of Developmental Neuropsychology, School of Psychology, Third Military Medical University, Chongqing, China.|Department of Neurology, Xinqiao Hospital, Third Military Medical University, Chongqing, China.
authors: Liang
authors: L
authors: Liu
authors: Department of Developmental Neuropsychology, School of Psychology, Third Military Medical University, Chongqing, China.
authors: Qin
authors: Q
authors: Zhang
authors: Department of Developmental Neuropsychology, School of Psychology, Third Military Medical University, Chongqing, China.
authors: Yulong
authors: Y
authors: Cai
authors: Department of Developmental Neuropsychology, School of Psychology, Third Military Medical University, Chongqing, China.|Department of Neurology, Xinqiao Hospital, Third Military Medical University, Chongqing, China.
authors: Dayu
authors: D
authors: Sun
authors: Department of Developmental Neuropsychology, School of Psychology, Third Military Medical University, Chongqing, China.
authors: Xie
authors: X
authors: He
authors: Department of Developmental Neuropsychology, School of Psychology, Third Military Medical University, Chongqing, China.
authors: Lian
authors: L
authors: Wang
authors: Department of Developmental Neuropsychology, School of Psychology, Third Military Medical University, Chongqing, China.
authors: Dan
authors: D
authors: Yu
authors: Department of Developmental Neuropsychology, School of Psychology, Third Military Medical University, Chongqing, China.
authors: Xin
authors: X
authors: Li
authors: Department of Neurology, Xinqiao Hospital, Third Military Medical University, Chongqing, China.
authors: Xiaoyi
authors: X
authors: Xiong
authors: Southwest Eye Hospital, Southwest Hospital, Third Military Medical University, Chongqing, China.
authors: Haiwei
authors: H
authors: Xu
authors: Department of Neurology, Xinqiao Hospital, Third Military Medical University, Chongqing, China.
authors: Qingwu
authors: Q
authors: Yang
authors: Department of Developmental Neuropsychology, School of Psychology, Third Military Medical University, Chongqing, China.
authors: Xiaotang
authors: X
authors: Fan
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology / Q000627:therapeutic use; D001522:Behavior, Animal / Q000187:drug effects; D049109:Cell Proliferation; D018891:Dentate Gyrus / Q000166:cytology / Q000502:physiology*; D003863:Depression / Q000139:chemically induced / Q000503:physiopathology*; D004121:Dimethyl Sulfoxide / Q000494:pharmacology; D004195:Disease Models, Animal; D063928:Ependymoglial Cells / Q000502:physiology; D006624:Hippocampus / Q000473:pathology / Q000502:physiology*; D006801:Humans; D007150:Immunohistochemistry; D008070:Lipopolysaccharides / Q000633:toxicity; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D017628:Microglia / Q000502:physiology; D016328:NF-kappa B / Q000378:metabolism; D055495:Neurogenesis / Q000187:drug effects*; D000077185:Resveratrol; D015398:Signal Transduction; D056564:Sirtuin 1 / Q000378:metabolism; D013267:Stilbenes / Q000494:pharmacology* / Q000627:therapeutic use; D013315:Stress, Psychological / Q000473:pathology*; D000072056:Transcription Factor HES-1 / Q000378:metabolism; D015854:Up-Regulation
chemical_list: D000975:Antioxidants; C489734:Hes1 protein, mouse; D008070:Lipopolysaccharides; D016328:NF-kappa B; D013267:Stilbenes; D000072056:Transcription Factor HES-1; C470545:Sirt1 protein, mouse; D056564:Sirtuin 1; D000077185:Resveratrol; D004121:Dimethyl Sulfoxide
keywords: LPS; Pathology Section; depression; neurogenesis; radial glial cells; resveratrol