title: Combined Detection of Serum IL-10, IL-17, and CXCL10 Predicts Acute Rejection Following Adult Liver Transplantation.
abstract: Discovery of non-invasive diagnostic and predictive biomarkers for acute rejection in liver transplant patients would help to ensure the preservation of liver function in the graft, eventually contributing to improved graft and patient survival. We evaluated selected cytokines and chemokines in the sera from liver transplant patients as potential biomarkers for acute rejection, and found that the combined detection of IL-10, IL-17, and CXCL10 at 1-2 weeks post-operation could predict acute rejection following adult liver transplantation with 97% specificity and 94% sensitivity.
authors: Department of Convergence Medicine & Asan Institute for Life Sciences, Department of Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, Korea.
authors: Nayoung
authors: N
authors: Kim
authors: Division of Liver Transplantation and Hepatobiliary Surgery, Department of Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, Korea.|Department of Hepatobiliary Pancreas Surgery, Korea University Anam Hospital, Seoul 02841, Korea.
authors: Young-In
authors: YI
authors: Yoon
authors: Department of Convergence Medicine & Asan Institute for Life Sciences, Department of Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, Korea.
authors: Hyun Ju
authors: HJ
authors: Yoo
authors: Department of Convergence Medicine & Asan Institute for Life Sciences, Department of Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, Korea.
authors: Eunyoung
authors: E
authors: Tak
authors: Division of Liver Transplantation and Hepatobiliary Surgery, Department of Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, Korea.
authors: Chul-Soo
authors: CS
authors: Ahn
authors: Division of Liver Transplantation and Hepatobiliary Surgery, Department of Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, Korea.
authors: Gi-Won
authors: GW
authors: Song
authors: Division of Liver Transplantation and Hepatobiliary Surgery, Department of Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, Korea.
authors: Sung-Gyu
authors: SG
authors: Lee
authors: Division of Liver Transplantation and Hepatobiliary Surgery, Department of Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, Korea.
authors: Shin
authors: S
authors: Hwang
mesh_terms: D000208:Acute Disease; D000328:Adult; D015415:Biomarkers / Q000097:blood*; D054357:Chemokine CXCL10 / Q000097:blood*; D005260:Female; D006084:Graft Rejection / Q000175:diagnosis*; D006801:Humans; D016753:Interleukin-10 / Q000097:blood*; D020381:Interleukin-17 / Q000097:blood*; D016031:Liver Transplantation; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D011379:Prognosis; D012680:Sensitivity and Specificity
chemical_list: D015415:Biomarkers; C114753:CXCL10 protein, human; D054357:Chemokine CXCL10; C508609:IL10 protein, human; D020381:Interleukin-17; D016753:Interleukin-10
keywords: acute rejection; biomarker; chemokine; cytokine; liver transplant