title: Tocilizumab treatment in childhood Takayasu arteritis: Case series of four patients and systematic review of the literature.
abstract: Our aim was to describe our experience with tocilizumab (interleukin 6 receptor antagonist) treatment in children with Takayasu arteritis and to review previous studies regarding tocilizumab use in Takayasu arteritis patients.
  
  
  
  We reviewed the charts of all pediatric Takayasu arteritis patients followed up between 2000 and 2015 in Department of Pediatric Rheumatology in Hacettepe University, Ankara, Turkey, and we present the patients who were treated with tocilizumab. We screened PubMed and MEDLINE for articles involving Takayasu arteritis patients treated with tocilizumab.
  
  
  
  We have followed four pediatric Takayasu arteritis patients who received tocilizumab. The median duration of immunosuppressive treatment before tocilizumab onset was 16 (1-60) months. The median duration of tocilizumab treatment was 9.5 (7-13) months. One of our patients received tocilizumab as a first line immunosuppressive treatment directly after methylprednisolone. Others were resistant to their initial immunosuppressive treatment (cyclophosphamide, methotrexate, or azathioprine). All achieved complete response to tocilizumab at the third month of treatment. None of the patients reported any adverse events during the follow-up. In literature review, we identified 19 articles describing 75 Takayasu arteritis patients treated with tocilizumab. Eight of these received tocilizumab before the age of 18 years. Tocilizumab was the first line immunosuppressive treatment in six patients (five adults and one child).
  
  
  
  Our small series suggests that tocilizumab may be a promising alternative for Takayasu arteritis treatment. Long-term controlled studies are warranted to provide better evidence for tocilizumab treatment in childhood Takayasu arteritis.
authors: Division of Rheumatology, Department of Pediatrics, Hacettepe University Faculty of Medicine, Ankara 06100, Turkey.
authors: Ezgi Deniz
authors: ED
authors: Batu
authors: Division of Rheumatology, Department of Pediatrics, Hacettepe University Faculty of Medicine, Ankara 06100, Turkey.
authors: Hafize Emine
authors: HE
authors: Sönmez
authors: Department of Radiology, Hacettepe University Faculty of Medicine, Ankara, Turkey.
authors: Tuncay
authors: T
authors: Hazırolan
authors: Division of Nephrology, Department of Pediatrics, Hacettepe University Faculty of Medicine, Ankara, Turkey.
authors: Fatih
authors: F
authors: Özaltın
authors: Division of Rheumatology, Department of Pediatrics, Hacettepe University Faculty of Medicine, Ankara 06100, Turkey.
authors: Yelda
authors: Y
authors: Bilginer
authors: Division of Rheumatology, Department of Pediatrics, Hacettepe University Faculty of Medicine, Ankara 06100, Turkey. Electronic address: sezaozen@hacettepe.edu.tr.
authors: Seza
authors: S
authors: Özen
mesh_terms: D000293:Adolescent; D061067:Antibodies, Monoclonal, Humanized / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D008297:Male; D012074:Remission Induction; D013625:Takayasu Arteritis / Q000188:drug therapy*; D016896:Treatment Outcome
chemical_list: D061067:Antibodies, Monoclonal, Humanized; D007166:Immunosuppressive Agents; C502936:tocilizumab
keywords: Child; Takayasu arteritis; Tocilizumab; Treatment