title: Programmed Ventricular Stimulation to Risk Stratify for Early Cardioverter-Defibrillator Implantation to Prevent Tachyarrhythmias following Acute Myocardial Infarction (PROTECT-ICD): Trial Protocol, Background and Significance.
abstract: The 'Programmed Ventricular Stimulation to Risk Stratify for Early Cardioverter-Defibrillator Implantation to Prevent Tachyarrhythmias following Acute Myocardial Infarction' (PROTECT-ICD) trial is an Australian-led multicentre randomised controlled trial targeting prevention of sudden cardiac death in patients who have at least moderately reduced cardiac function following a myocardial infarct (MI). The primary objective of the trial is to assess whether electrophysiological study to guide prophylactic implantation of an implantable cardioverter-defibrillator (ICD) early following MI (first 40 days) will lead to a significant reduction in sudden cardiac death and non-fatal arrhythmia. The secondary objective is to assess the utility of cardiac MRI (CMR) in assessing early myocardial characteristics, and its predictive value for both inducible ventricular tachycardia (VT) at EPS and SCD/ non-fatal arrhythmia at follow-up.
authors: MonashHEART, Monash Medical Centre, Melbourne, Vic, Australia; Monash University, Melbourne, Vic, Australia.
authors: Sarah
authors: S
authors: Zaman
authors: Department of Cardiology, The Alfred Hospital, Melbourne, Vic, Australia; Baker IDI Heart and Diabetes Institute, Melbourne, Vic, Australia.
authors: Andrew J
authors: AJ
authors: Taylor
authors: Waikato Hospital, Hamilton, New Zealand.
authors: Martin
authors: M
authors: Stiles
authors: Department of Cardiology, Westmead Hospital, Sydney, NSW, Australia; The University of Sydney, Sydney, NSW, Australia; The George Institute for Global Health, Sydney, NSW, Australia.
authors: Clara
authors: C
authors: Chow
authors: Department of Cardiology, Westmead Hospital, Sydney, NSW, Australia; The University of Sydney, Sydney, NSW, Australia. Electronic address: pramesh.kovoor@sydney.edu.au.
authors: Pramesh
authors: P
authors: Kovoor
mesh_terms: D006801:Humans; D001315:Australia; D017147:Defibrillators, Implantable; D006352:Heart Ventricles / Q000503:physiopathology; D015337:Multicenter Studies as Topic; D009203:Myocardial Infarction / Q000150:complications / Q000503:physiopathology / Q000628:therapy; D016032:Randomized Controlled Trials as Topic; D013610:Tachycardia / Q000209:etiology / Q000503:physiopathology / Q000517:prevention & control
keywords: Implantable-cardioverter defibrillator; Myocardial infarction; Primary prevention; Randomised controlled trial; Sudden cardiac death