title: Fabrication of aggregation induced emission active luminescent chitosan nanoparticles via a "one-pot" multicomponent reaction.
abstract: Chitosan based nanomaterials have been extensively examined for biomedical applications for their biodegradability, low toxicity, biological activity and low cost. In this work, a novel strategy for fabrication of luminescent polymeric nanoparticles (LPNs) based on aggregation induced emission (AIE) dye and water soluble chitosan (WS-Chitosan) were firstly developed via a highly efficient mercaptoacetic acid (MA) locking imine reaction. In this multicomponent reaction (MCR), MA serves as "lock" to connect 9,10-Bis(aldehydephenl)anthracene dye (An-CHO) and amino-containing WS-Chitosan under mild reaction conditions. The obtained WS-Chitosan@An-CHO LPNs show strong yellow emission and great water dispersibility. Biological evaluation results demonstrated that synthetic luminescent polymeric nanoparticles possess desirable cytocompatibility and distinct imaging properties. Therefore, we have developed a facile and useful method to fabricate AIE active nanoprobes with desirable properties for various biomedical applications. This strategy should be a general and easy handling tool to fabricate many other AIE dye based materials.
authors: Department of Chemistry and Jiangxi Provincial Key Laboratory of New Energy Chemistry, Nanchang University, 999 Xuefu Avenue, Nanchang 330031, China.
authors: Qing
authors: Q
authors: Wan
authors: Department of Chemistry and Jiangxi Provincial Key Laboratory of New Energy Chemistry, Nanchang University, 999 Xuefu Avenue, Nanchang 330031, China.
authors: Meiying
authors: M
authors: Liu
authors: Department of Chemistry and Jiangxi Provincial Key Laboratory of New Energy Chemistry, Nanchang University, 999 Xuefu Avenue, Nanchang 330031, China.
authors: Dazhuang
authors: D
authors: Xu
authors: Department of Chemistry and Jiangxi Provincial Key Laboratory of New Energy Chemistry, Nanchang University, 999 Xuefu Avenue, Nanchang 330031, China.
authors: Liucheng
authors: L
authors: Mao
authors: Department of Chemistry and Jiangxi Provincial Key Laboratory of New Energy Chemistry, Nanchang University, 999 Xuefu Avenue, Nanchang 330031, China.
authors: Jianwen
authors: J
authors: Tian
authors: Department of Chemistry and Jiangxi Provincial Key Laboratory of New Energy Chemistry, Nanchang University, 999 Xuefu Avenue, Nanchang 330031, China.
authors: Hongye
authors: H
authors: Huang
authors: Department of Chemistry and Jiangxi Provincial Key Laboratory of New Energy Chemistry, Nanchang University, 999 Xuefu Avenue, Nanchang 330031, China.
authors: Peng
authors: P
authors: Gao
authors: Department of Chemistry and Jiangxi Provincial Key Laboratory of New Energy Chemistry, Nanchang University, 999 Xuefu Avenue, Nanchang 330031, China. Electronic address: fengjiedeng@aliyun.com.
authors: Fengjie
authors: F
authors: Deng
authors: Department of Chemistry and Jiangxi Provincial Key Laboratory of New Energy Chemistry, Nanchang University, 999 Xuefu Avenue, Nanchang 330031, China. Electronic address: xiaoyongzhang1980@gmail.com.
authors: Xiaoyong
authors: X
authors: Zhang
authors: Department of Chemistry and the Tsinghua Center for Frontier Polymer Research, Tsinghua University, Beijing 100084, PR China. Electronic address: weiyen@tsinghua.edu.cn.
authors: Yen
authors: Y
authors: Wei
mesh_terms: D000873:Anthracenes / Q000737:chemistry / Q000494:pharmacology; D048271:Chitosan / Q000737:chemistry / Q000494:pharmacology; D005456:Fluorescent Dyes / Q000737:chemistry / Q000494:pharmacology; D006367:HeLa Cells; D006801:Humans; D049449:Luminescence; D008422:Materials Testing; D053758:Nanoparticles / Q000737:chemistry*
chemical_list: D000873:Anthracenes; D005456:Fluorescent Dyes; D048271:Chitosan
keywords: Aggregation induced emission; Biomedical applications; Luminescent polymeric nanoparticles; Multicomponent reaction; Water solube chitosan