title: Past Cardiovascular Episodes Deteriorate Quality of Life of Patients With Type 1 Diabetes and End-stage Kidney Disease After Kidney or Simultaneous Pancreas and Kidney Transplantation.
abstract: BACKGROUND
  The beneficial influence of kidney (KTx) or simultaneous pancreas and kidney transplantation (SPK) on quality of life (QOL) in patients with end-stage kidney disease caused by type 1 diabetes mellitus was confirmed in many studies. The aim of this study was to identify factors that influence QOL of patients in long-term follow-up after SPK or KTx.
  
  
  METHODS
  Twenty-seven SPK and 26 KTx patients with good function of transplanted organs at least 1 year after transplantation were enrolled into the analysis. To estimate QOL of the recipients the Kidney Disease and Quality of Life Short Form was applied.
  
  
  RESULTS
  Within the whole analyzed group, the necessity of exogenous insulin administration correlated (P < .05) with symptom/problem list (γ = -0.35), effects of kidney disease (-0.38), cognitive function (-0.47), sleep (-0.42), overall health (-0.47), physical functioning (-0.61), role-physical (-0.32), pain (-0.50), general health (-0.32), emotional well-being (-0.31), role-emotional (-0.36), social function (-0.33), energy/fatigue (-0.44), and the SF-12 physical composite (-0.44). History of cardiovascular episode correlated (P < .05) with symptom/problem list (γ = -0.59), effects of kidney disease (-0.46), burden of kidney disease (-0.56), sleep (-0.54), social support (-0.51), physical functioning (-0.55), role-physical (-0.70), pain (-0.60), general health (-0.57), emotional well-being (-0.45), role-emotional (-0.95), social function (-0.58), energy/fatigue (-0.59), SF-12 physical composite (-0.45), and SF-12 mental composite (-0.83).
  
  
  CONCLUSIONS
  Exogenous insulin administration and history of cardiovascular episode are the most important factors influencing QOL in patients after SPK or KTx, particularly worsening its physical components.
authors: Department of General, Vascular and Transplant Surgery, Medical University of Silesia, Katowice, Poland.
authors: D
authors: D
authors: Bożek-Pająk
authors: Department of Pulmonology, Medical University of Silesia, Katowice, Poland. Electronic address: ziacek@mp.pl.
authors: J
authors: J
authors: Ziaja
authors: Department of General, Vascular and Transplant Surgery, Medical University of Silesia, Katowice, Poland.
authors: A
authors: A
authors: Kowalik
authors: Department of Pulmonology, Medical University of Silesia, Katowice, Poland.
authors: M
authors: M
authors: Farnik
authors: Department of Nephrology, Transplantation and Internal Medicine, Medical University of Silesia, Katowice, Poland.
authors: A
authors: A
authors: Kolonko
authors: Department of Nephrology, Transplantation and Internal Medicine, Medical University of Silesia, Katowice, Poland.
authors: A
authors: A
authors: Kujawa-Szewieczek
authors: Department of Nephrology and Transplantation Medicine, Wroclaw Medical University, Wrocław, Poland.
authors: D
authors: D
authors: Kamińska
authors: Department of Nephrology and Transplantation Medicine, Wroclaw Medical University, Wrocław, Poland.
authors: M
authors: M
authors: Kuriata-Kordek
authors: Department of General, Vascular and Transplant Surgery, Medical University of Silesia, Katowice, Poland.
authors: R
authors: R
authors: Król
authors: Department of Nephrology, Transplantation and Internal Medicine, Medical University of Silesia, Katowice, Poland.
authors: A
authors: A
authors: Więcek
authors: Department of Nephrology and Transplantation Medicine, Wroclaw Medical University, Wrocław, Poland.
authors: M
authors: M
authors: Klinger
authors: Department of General, Vascular and Transplant Surgery, Medical University of Silesia, Katowice, Poland.
authors: L
authors: L
authors: Cierpka
mesh_terms: D000328:Adult; D003131:Combined Modality Therapy; D003922:Diabetes Mellitus, Type 1 / Q000150:complications* / Q000188:drug therapy / Q000523:psychology; D058065:Diabetic Cardiomyopathies / Q000150:complications* / Q000523:psychology; D003928:Diabetic Nephropathies / Q000209:etiology / Q000523:psychology* / Q000601:surgery; D005260:Female; D006801:Humans; D007328:Insulin / Q000627:therapeutic use; D007676:Kidney Failure, Chronic / Q000209:etiology / Q000523:psychology* / Q000601:surgery; D016030:Kidney Transplantation / Q000523:psychology*; D008297:Male; D008875:Middle Aged; D016035:Pancreas Transplantation / Q000523:psychology*; D011184:Postoperative Period; D057234:Preoperative Period; D011788:Quality of Life
chemical_list: D007328:Insulin