title: Gut Microbiota and Alcoholic Liver Disease.
abstract: The gut-liver axis model has often explained liver disease physiopathology. Among the latter we can mention Non-Alcoholic Liver Steatosis (NAFLD), Liver Steatohepatitis (NASH), liver cirrhosis. In this frame an altered Intestinal Permeability (IP) is the gate for antigenic/toxic substances from gut lumen until target organs such as liver in NAFLD. Altered intestinal permeability was discovered almost forty years ago as consequence of acute and chronic alcohol ingestion. Alcohol Liver Disease (ALD) is a systemic pathology whose beginning and end belong to the intestine. Several recent evidences from the literature show how gut microbiota composition can be altered by alcohol, affects IP and can be modulated by several nonpharmacological and pharmacological agents, becoming the target for ALD treatment. In this review we describe the definition of ALD, gut microbiota composition in healthy and ALD, definition and role of IP in ALD physiopathology and emerging evidences on gut microbiota modulation in ALD treatment from preliminary clinical and non-clinical studies.
authors: Division of Gastroenterology, Umberto I University Hospital, 'Sapienza' University of Rome, Rome, Viale del Policlinico 155, Italy.
authors: Emidio
authors: E
authors: Scarpellini
authors: Mariana
authors: M
authors: Forlino
authors: Marinella
authors: M
authors: Lupo
authors: Carlo
authors: C
authors: Rasetti
authors: Giammarco
authors: G
authors: Fava
authors: Ludovico
authors: L
authors: Abenavoli
authors: Adriano
authors: A
authors: De Santis
mesh_terms: D000069196:Gastrointestinal Microbiome / Q000502:physiology*; D006801:Humans; D008108:Liver Diseases, Alcoholic / Q000378:metabolism* / Q000382:microbiology* / Q000503:physiopathology