title: Experimental investigations on the fluid-mechanics of an electrospun heart valve by means of particle image velocimetry.
abstract: End-stage failing heart valves are currently replaced by mechanical or biological prostheses. Both types positively contribute to restore the physiological function of native valves, but a number of drawbacks limits the expected performances. In order to improve the outcome, tissue engineering can offer an alternative approach to design and fabricate innovative heart valves capable to support the requested function and to promote the formation of a novel, viable and correctly operating physiological structure. This potential result is particularly critical if referred to the aortic valve, being the one mainly exposed to structural and functional degeneration. In this regard, the here proposed study presents the fabrication and in vitro characterization of a bioresorbable electrospun heart valve prosthesis using the particle image velocimetry technique either in physiological and pathological fluid dynamic conditions. The scaffold was designed to reproduce the aortic valve geometry, also mimicking the fibrous structure of the natural extracellular matrix. To evaluate its performances for possible implantation, the flow fields downstream the valve were accurately investigated and compared. The experimental results showed a correct functionality of the device, supported by the formation of vortex structures at the edge of the three cusps, with Reynolds stress values below the threshold for the risk of hemolysis (which can be comprised in the range 400-4000N/m(2) depending on the exposure period), and a good structural resistance to the mechanical loads generated by the driving pressure difference.
authors: Department of Enterprise Engineering, University of Rome Tor Vergata, Roma, Italy. Electronic address: costantino.delgaudio@uniroma2.it.
authors: Costantino
authors: C
authors: Del Gaudio
authors: Department of Mechanical & Aerospace Engineering, University of Rome La Sapienza, Roma, Italy.
authors: Pier Luca
authors: PL
authors: Gasbarroni
authors: Department of Mechanical & Aerospace Engineering, University of Rome La Sapienza, Roma, Italy. Electronic address: giampaolo.romano@uniroma1.it.
authors: Giovanni Paolo
authors: GP
authors: Romano
mesh_terms: D001021:Aortic Valve / Q000033:anatomy & histology*; D005109:Extracellular Matrix; D006350:Heart Valve Prosthesis; D006801:Humans; D011474:Prosthesis Design; D012212:Rheology; D023822:Tissue Engineering; D054457:Tissue Scaffolds
keywords: Electrospinning; Heart valve; Particle image velocimetry