title: Comparing Outcomes of Two Types of Bariatric Surgery in an Adolescent Obese Population: Roux-en-Y Gastric Bypass vs. Sleeve Gastrectomy.
abstract: BACKGROUND
  Obesity is prevalent among adolescents and is associated with serious health consequences. Roux-en-Y Gastric Bypass (RYGB) and Sleeve Gastrectomy (SG) are bariatric procedures that cause significant weight loss in adults and are increasingly being performed in adolescents with morbid obesity. Data comparing outcomes of RYGB vs. SG in this age-group are scarce. This study aims to compare short-term (1-6 months) and longer-term (7-18 months) body mass index (BMI) and biochemical outcomes following RYGB and SG in adolescents/young adults.
  
  
  METHODS
  A retrospective study using data extracted from medical records of patients 16-21 years who underwent RYGB or SG between 2012 and 2014 at a tertiary care academic medical center.
  
  
  RESULTS
  Forty-six patients were included in this study: 24 underwent RYGB and 22 underwent SG. Groups did not differ for baseline age, sex, race, or BMI. BMI reductions were significant at 1-6 months and 7-18 months within groups (p < 0.0001), but did not differ by surgery type (p = 0.65 and 0.09, for 1-6 months and 7-18 months, respectively). Over 7-18 months, within-group improvement in low-density lipoprotein (LDL) (-24 ± 6 in RYGB, p = 0.003, vs. -7 ± 9 mg/dl in SG, p = 0.50) and non-high-density lipoprotein (non-HDL) cholesterol (-23 ± 8 in RYGB, p = 0.02, vs. -12 ± 7 in SG, p = 0.18) appeared to be of greater magnitude following RYGB. However, differences between groups did not reach statistical significance. When divided by non-alcoholic steatohepatitis stages (NASH), patients with Stage II-III NASH had greater reductions in alanine aminotransferase levels vs. those with Stage 0-I NASH (-45 ± 18 vs. -9 ± 3, p = 0.01) after 7-18 months. RYGB and SG groups did not differ for the magnitude of post-surgical changes in liver enzymes.
  
  
  CONCLUSIONS
  RYGB and SG did not differ for the magnitude of BMI reduction across groups, though changes trended higher following RYGB. Further prospective studies are needed to confirm these findings.
authors: Neuroendocrine Unit, Massachusetts General Hospital, Harvard Medical School , Boston, MA , USA.
authors: Giovana D
authors: GD
authors: Maffazioli
authors: Pediatric Endocrine Unit, Massachusetts General Hospital for Children, Harvard Medical School, Boston, MA, USA; Weight Center, Massachusetts General Hospital, Boston, MA, USA; Department of Medicine-Gastroenterology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
authors: Fatima Cody
authors: FC
authors: Stanford
authors: Neuroendocrine Unit, Massachusetts General Hospital, Harvard Medical School , Boston, MA , USA.
authors: Karen J
authors: KJ
authors: Campoverde Reyes
authors: Neuroendocrine Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA; Pediatric Endocrine Unit, Massachusetts General Hospital for Children, Harvard Medical School, Boston, MA, USA.
authors: Takara L
authors: TL
authors: Stanley
authors: Neuroendocrine Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA; Pediatric Endocrine Unit, Massachusetts General Hospital for Children, Harvard Medical School, Boston, MA, USA.
authors: Vibha
authors: V
authors: Singhal
authors: Department of Medicine-Gastroenterology, Massachusetts General Hospital, Harvard Medical School , Boston, MA , USA.
authors: Kathleen E
authors: KE
authors: Corey
authors: Weight Center, Massachusetts General Hospital, Boston, MA, USA; Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
authors: Janey S
authors: JS
authors: Pratt
authors: Department of Radiology, Massachusetts General Hospital, Harvard Medical School , Boston, MA , USA.
authors: Miriam A
authors: MA
authors: Bredella
authors: Neuroendocrine Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA; Pediatric Endocrine Unit, Massachusetts General Hospital for Children, Harvard Medical School, Boston, MA, USA.
authors: Madhusmita
authors: M
authors: Misra
keywords: Roux-en-Y gastric bypass; adolescence; bariatric surgery; obesity; sleeve gastrectomy