title: β3-Adrenoreceptors in the thick ascending limb of Henle and in principal cells of the collecting duct work to concentrate urine.
abstract: β3-Adrenoreceptors and their importance to increase sodium reabsorption in the thick ascending loop of Henle and to increase water reabsorption in principal cells of the collecting duct are, for the first time, described here. This is an integrated brain response to dehydration perceived by osmosensitive cells in the hypothalamus and triggering through vasopressin axonal and dendritic release a coordinated response implicating vasopressin V2 receptors and β3-adrenoreceptors on the luminal membrane of cortical collecting duct cells.
authors: Department of Medicine and Molecular and Integrative Physiology, University of Montreal, Montréal, Québec, Canada; Service de Néphrologie, Hôpital du Sacré-Coeur de Montréal, Montréal, Québec, Canada. Electronic address: daniel.bichet@umontreal.ca.
authors: Daniel G
authors: DG
authors: Bichet
mesh_terms: D001127:Arginine Vasopressin; D006801:Humans; D007684:Kidney Tubules; D007685:Kidney Tubules, Collecting; D008138:Loop of Henle; D022702:Receptors, Adrenergic, beta-3; D017483:Receptors, Vasopressin; D014667:Vasopressins
chemical_list: D022702:Receptors, Adrenergic, beta-3; D017483:Receptors, Vasopressin; D014667:Vasopressins; D001127:Arginine Vasopressin