title: Cyclen lanthanide-based micellar structures for application as luminescent [Eu(iii)] and magnetic [Gd(iii)] resonance imaging (MRI) contrast agents.
abstract: The synthesis of coordinatively unsaturated tetra-substituted 1,4,7,10-tetraazacyclododecane (cyclen) lanthanide complexes is described; these structures, possessing hydrophobic (C12-alkyl) tails and hydrophilic head groups, self-assemble into supramolecular micellar structures in aqueous solution, and hence can be utilised as novel contrast agents for MRI.
authors: School of Chemistry, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland. gunnlaut@tcd.ie.
authors: Esther M
authors: EM
authors: Surender
authors: Steve
authors: S
authors: Comby
authors: Sarah
authors: S
authors: Martyn
authors: Brenton
authors: B
authors: Cavanagh
authors: T Clive
authors: TC
authors: Lee
authors: Dermot F
authors: DF
authors: Brougham
authors: Thorfinnur
authors: T
authors: Gunnlaugsson
mesh_terms: D003287:Contrast Media / Q000737:chemistry*; D056831:Coordination Complexes / Q000737:chemistry*; D000080027:Cyclams; D005063:Europium / Q000737:chemistry; D005682:Gadolinium / Q000737:chemistry; D006571:Heterocyclic Compounds / Q000737:chemistry; D057927:Hydrophobic and Hydrophilic Interactions; D007477:Ions / Q000737:chemistry; D028581:Lanthanoid Series Elements / Q000737:chemistry*; D008163:Luminescent Measurements; D008279:Magnetic Resonance Imaging; D008823:Micelles
chemical_list: D003287:Contrast Media; D056831:Coordination Complexes; D000080027:Cyclams; D006571:Heterocyclic Compounds; D007477:Ions; D028581:Lanthanoid Series Elements; D008823:Micelles; D005063:Europium; C038072:cyclen; D005682:Gadolinium