title: Is there an influence of hepatic steatosis on fibrosis and necroinflammation in young patients with chronic viral hepatitis B?
abstract: OBJECTIVE
  Our aim was to investigate the association of liver fibrosis and necroinflammation with HS in untreated young patients with chronic hepatitis B (CHB).
  
  
  METHODS
  A retrospective study was conducted in a military hospital in Turkey. A total of 254 subjects with CHB were included in this study. These subjects were divided into two groups: group 1 consisted of patients with hepatic steatosis (HS) according to ultrasonography (USG) and group 2 consisted of non-HS subjects. Sociodemographic, biochemical, histopathological, virological and USG results were recorded for both groups retrospectively. Statistical analysis was performed using SPSS 22.0.
  
  
  RESULTS
  The prevalence of HS was found to be 11.4%. A significant statistical difference was found between group 1 and group 2 regarding the fibrosis degree (p = 0.045). No statistically significant difference was noted between two groups for age, levels of ALT, AST, HBeAg, HBV-DNA levels, HAI scores, diagnosis age and duration of CHB. No difference was noted between the grade of HS and variables. A positive correlation was found between fibrosis groups and the grade of HS (p = 0.012, r = 0.158) and between HAI groups and the grade of HS (p = 0.029, r = 0.137).
  
  
  CONCLUSIONS
  The prevalence of steatosis was not higher in patients with CHB. HS is associated with advanced hepatic fibrosis, but not viral liver disease.
authors: a Department of Infectious Diseases and Clinical Microbiology , Etimesgut Military Hospital , Ankara , Turkey.
authors: Zehra
authors: Z
authors: Karacaer
authors: b Department of Radiology , Etimesgut Military Hospital , Ankara , Turkey.
authors: Gokcan
authors: G
authors: Okur
authors: c Department of Pathology , Etimesgut Military Hospital , Ankara , Turkey.
authors: Hakan
authors: H
authors: Cermik
authors: d Department of Pediatrics , Etimesgut Military Hospital , Ankara , Turkey.
authors: Demet
authors: D
authors: Altun
mesh_terms: D000328:Adult; D001707:Biopsy, Needle / Q000379:methods; D005234:Fatty Liver / Q000150:complications / Q000175:diagnosis / Q000453:epidemiology / Q000821:virology; D005260:Female; D019694:Hepatitis B, Chronic / Q000150:complications / Q000175:diagnosis / Q000453:epidemiology; D006801:Humans; D007249:Inflammation / Q000473:pathology; D008099:Liver / Q000000981:diagnostic imaging / Q000473:pathology; D008103:Liver Cirrhosis / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology / Q000821:virology; D008297:Male; D009336:Necrosis / Q000473:pathology; D015995:Prevalence; D012189:Retrospective Studies; D013223:Statistics as Topic; D014421:Turkey / Q000453:epidemiology; D014463:Ultrasonography / Q000379:methods
keywords: Fibrosis; hepatic steatosis; hepatitis B; necroinflammation; untreated; young