title: NAGging Hexokinase PEPs up NLRP3.
abstract: Recognition of peptidoglycan is integral to detection of gram-positive bacterial pathogens. In a recent issue of Cell, Wolf et al. (2016) report that detection of the N-acetylglucosamine component of peptidoglycan by the glycolytic enzyme hexokinase activates the NLRP3 inflammasome, revealing an intriguing interplay between pathogen detection and metabolism.
authors: Institute for Systems Biology, Seattle WA 98109, USA.
authors: Henry
authors: H
authors: Hampton
authors: Institute for Systems Biology, Seattle WA 98109, USA.
authors: Carolyn
authors: C
authors: Hutcheon
authors: Institute for Systems Biology, Seattle WA 98109, USA; Departments of Immunology and Global Health, University of Washington, Seattle, WA 98195, USA. Electronic address: nsubrama@systemsbiology.org.
authors: Naeha
authors: N
authors: Subramanian
mesh_terms: D000117:Acetylglucosamine; D002473:Cell Wall; D006593:Hexokinase; D058847:Inflammasomes; D010457:Peptidoglycan
chemical_list: D058847:Inflammasomes; D010457:Peptidoglycan; D006593:Hexokinase; D000117:Acetylglucosamine