title: Is hepatic lipogenesis fundamental for NAFLD/NASH? A focus on the nuclear receptor coactivator PGC-1β.
abstract: Non-alcoholic fatty liver diseases are the hepatic manifestation of metabolic syndrome. According to the classical pattern of NAFLD progression, de novo fatty acid synthesis has been incriminated in NAFLD progression. However, this hypothesis has been challenged by the re-evaluation of NAFLD development mechanisms together with the description of the role of lipogenic genes in NAFLD and with the recent observation that PGC-1β, a nuclear receptor/transcription factor coactivator involved in the transcriptional regulation of lipogenesis, displays protective effects against NAFLD/NASH progression. In this review, we focus on the implication of lipogenesis and triglycerides synthesis on the development of non-alcoholic fatty liver diseases and discuss the involvement of these pathways in the protective role of PGC-1β toward these hepatic manifestations.
authors: Clinica Medica "Cesare Frugoni", Department of Interdisciplinary Medicine, University of Bari "Aldo Moro", Piazza Giulio Cesare 11, 70124, Bari, Italy.|IRCCS Istituto Tumori "Giovanni Paolo II", Viale O. Flacco 65, 70124, Bari, Italy.
authors: Simon
authors: S
authors: Ducheix
authors: Clinica Medica "Cesare Frugoni", Department of Interdisciplinary Medicine, University of Bari "Aldo Moro", Piazza Giulio Cesare 11, 70124, Bari, Italy.
authors: Maria Carmela
authors: MC
authors: Vegliante
authors: Department of Basic Medical Sciences, Neurosciences and Sense Organs, University of Bari "Aldo Moro", Piazza Giulio Cesare 11, 70124, Bari, Italy.
authors: Gaetano
authors: G
authors: Villani
authors: Clinica Medica "Cesare Frugoni", Department of Interdisciplinary Medicine, University of Bari "Aldo Moro", Piazza Giulio Cesare 11, 70124, Bari, Italy.
authors: Nicola
authors: N
authors: Napoli
authors: Clinica Medica "Cesare Frugoni", Department of Interdisciplinary Medicine, University of Bari "Aldo Moro", Piazza Giulio Cesare 11, 70124, Bari, Italy.
authors: Carlo
authors: C
authors: Sabbà
authors: Clinica Medica "Cesare Frugoni", Department of Interdisciplinary Medicine, University of Bari "Aldo Moro", Piazza Giulio Cesare 11, 70124, Bari, Italy. antonio.moschetta@uniba.it.|IRCCS Istituto Tumori "Giovanni Paolo II", Viale O. Flacco 65, 70124, Bari, Italy. antonio.moschetta@uniba.it.
authors: Antonio
authors: A
authors: Moschetta
mesh_terms: D000818:Animals; D018450:Disease Progression; D006801:Humans; D050155:Lipogenesis; D008099:Liver / Q000378:metabolism*; D008954:Models, Biological; D065626:Non-alcoholic Fatty Liver Disease / Q000453:epidemiology / Q000378:metabolism* / Q000473:pathology; D056918:Nuclear Receptor Coactivators / Q000378:metabolism*
chemical_list: D056918:Nuclear Receptor Coactivators
keywords: Coactivator; Lipogenesis; Liver; NAFLD; NASH; Nuclear receptor; PGC-1; Steatohepatitis