title: Synthesis and characterization of chitosan/curcumin blends based polyurethanes.
abstract: In this work, new hexamethylene diisocyanate (HMDI) and hyroxylterminated polybutadiene (HTPB) based polyurethanes (PUs) were prepared following step growth polymerization by the introduction of varying mole ratio of chitosan (CH) and curcumin (CUR). Structural study of blends through infrared spectroscopy confirmed the incorporation of CH and CUR into the backbone of the PU. The scanning electron microscopic (SEM) study confirmed the well dispersion of incorporated chitosan/curcumin and homogeneity of surface of synthesized samples. Thermogravimetric analysis (TGA) of PU blends indicated a better thermal stability with 0.25M:0.75M of chitosan to curcumin. Mechanical properties such as modulus and tensile strength of PU blends were found to be better with higher contents of chitosan and curcumin. The same extender composition (1mol BDO, 075mol chitosan and 0.25mol curcumin) based PU showed higher substantial of antimicrobial activity as compared to the all other PUs. On the whole, this work is actually a step towards the generation of novel biocompatible materials preferably useful for biomedical applications.
authors: Institute of Chemistry, Government College University, Faisalabad 38030, Pakistan.
authors: Fatima
authors: F
authors: Zia
authors: Institute of Chemistry, Government College University, Faisalabad 38030, Pakistan. Electronic address: ziakmpkpolym@yahoo.com.
authors: Khalid Mahmood
authors: KM
authors: Zia
authors: Institute of Chemistry, Government College University, Faisalabad 38030, Pakistan.
authors: Mohammad
authors: M
authors: Zuber
authors: Institute of Chemistry, Government College University, Faisalabad 38030, Pakistan.
authors: Saima
authors: S
authors: Rehman
authors: Institute of Chemistry, Government College University, Faisalabad 38030, Pakistan.
authors: Shazia
authors: S
authors: Tabasum
authors: Department of Zoology, Government College University, Faisalabad 38030, Pakistan.
authors: Salma
authors: S
authors: Sultana
mesh_terms: D001412:Bacillus subtilis / Q000187:drug effects / Q000254:growth & development; D001672:Biocompatible Materials / Q000737:chemistry* / Q000494:pharmacology; D002070:Butadienes / Q000737:chemistry; D048271:Chitosan / Q000737:chemistry* / Q000494:pharmacology; D003474:Curcumin / Q000737:chemistry* / Q000494:pharmacology; D052978:Disk Diffusion Antimicrobial Tests; D055119:Elastic Modulus; D020724:Elastomers / Q000737:chemistry; D004926:Escherichia coli / Q000187:drug effects / Q000254:growth & development; D017953:Isocyanates / Q000737:chemistry; D008422:Materials Testing; D016979:Pasteurella multocida / Q000187:drug effects / Q000254:growth & development; D058105:Polymerization; D011140:Polyurethanes / Q000737:chemistry* / Q000494:pharmacology; D013211:Staphylococcus aureus / Q000187:drug effects / Q000254:growth & development; D013499:Surface Properties; D013718:Tensile Strength
chemical_list: D001672:Biocompatible Materials; D002070:Butadienes; D020724:Elastomers; D017953:Isocyanates; D011140:Polyurethanes; C015262:1,6-hexamethylene diisocyanate; C028834:polybutadiene; D048271:Chitosan; D003474:Curcumin
keywords: Chitosan; Curcumin; Polyurethane