title: [The effect of locally injected betamethasone on collagen deposition in benign central airway stenosis].
abstract: OBJECTIVE
  To assess the effects of locally injected betamethasone on cicatricial tissue hyperplasia in patients with benign central airway stenosis.
  
  
  METHODS
  A prospective study was conducted with 2 treatment modalities: conventional interventional(CI)therapy, and CI combined with local betamethasone injection(LBI). The average optical density value of TGF-β1 and collagen density in the local airway tissues were compared before therapy and 7 d after the CI treatment and the LBI treatment, respectively.
  
  
  RESULTS
  Six patients were recruited in this study from May 2013 to June 2015.The results showed significant statistical differences by paired t-test in TGF-β1: 92±38 vs 164±47(t=-7.984, P=0.000)before and after the CI treatment, respectively; 128±45 vs 78±40 (t=10.055, P=0.000)before and after the LBI treatment, respectively. The collagen density was 91 932±59 520 vs 150 252±76 673(t=-8.105, P=0.000) before and after the CI treatment, respectively; 107 024±54 880 vs 114 038±50 772(t=-0.621, P=0.54) before and after the LBI treatment, respectively.Trend comparisons made before and after the treatments showed significant statistical differences in TGF-β1(F=712.139, P=0.000) and in the collagen density (F=261.256, P=0.000)between the CI treatment and the LBI treatment groups.
  
  
  CONCLUSIONS
  The CI treatment was shown to stimulate the production of TGF-β1 and the deposition of collagen, while the LBI treatment was shown to reduce the production of TGF-β1 and alleviate the deposition of collagen from the stimulation of the CI treatment.
authors: Fujian Medical University Second Affiliated Hospital, Quanzhou 362000, China.
authors: Y F
authors: YF
authors: Chen
authors: D F
authors: DF
authors: Xu
authors: Y M
authors: YM
authors: Zeng
authors: H P
authors: HP
authors: Zhang
authors: D Y
authors: DY
authors: Yang
authors: X Y
authors: XY
authors: Chen
authors: J
authors: J
authors: Zhang
mesh_terms: D001623:Betamethasone / Q000627:therapeutic use*; D017439:Cicatrix, Hypertrophic / Q000188:drug therapy* / Q000473:pathology; D003094:Collagen / Q000378:metabolism*; D003251:Constriction, Pathologic / Q000188:drug therapy; D006801:Humans; D007267:Injections; D011446:Prospective Studies; D012137:Respiratory System / Q000187:drug effects* / Q000473:pathology*; D053773:Transforming Growth Factor beta1 / Q000378:metabolism
chemical_list: D053773:Transforming Growth Factor beta1; D003094:Collagen; D001623:Betamethasone