title: A Phytosterol-Enriched Spread Improves Lipid Profile and Insulin Resistance of Women with Gestational Diabetes Mellitus: A Randomized, Placebo-Controlled Double-Blind Clinical Trial.
abstract: Gestational diabetes mellitus (GDM) has become a serious health risk among pregnant women throughout the world. Phytosterol-enriched margarines are capable of lowering total cholesterol (TC) and low-density lipoprotein (LDL), but little is known about its effects on GDM. We aimed to examine the effects of daily consumption of a phytosterol-enriched spread on insulin resistance and lipid profile in pregnant GDM women.
  
  
  
  Pregnant women suffering from GDM in their second trimester were recruited and randomly assigned to consume a margarine spread either with or without phytosterols daily for 16 weeks. Serum lipid profile and glucose and insulin metabolisms were assessed at week 0 (baseline) and week 16 (end of trial).
  
  
  
  After 16 weeks, levels of triacylglycerol, TC, and LDL were significantly decreased, while high-density lipoprotein was significantly increased, compared with the baseline in the phytosterol group. In addition, in the same treatment group, glucose metabolic parameters, including fasting plasma glucose, serum insulin levels, the quantitative insulin check index, homeostasis model of assessment of insulin resistance, and β-cell function, were also significantly improved.
  
  
  
  Daily consumption of a phytosterol-enriched spread improved insulin resistance and lipid profile in women with GDM.
authors: The Second Department of Obstetrics, Cangzhou Central Hospital , Cangzhou, China .
authors: Qin
authors: Q
authors: Li
authors: The Second Department of Obstetrics, Cangzhou Central Hospital , Cangzhou, China .
authors: Baoheng
authors: B
authors: Xing
mesh_terms: D000328:Adult; D001786:Blood Glucose / Q000032:analysis*; D016640:Diabetes, Gestational / Q000097:blood*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance / Q000502:physiology*; D050356:Lipid Metabolism / Q000187:drug effects*; D008055:Lipids / Q000097:blood*; D010840:Phytosterols / Q000008:administration & dosage*; D011247:Pregnancy; D011262:Pregnancy Trimester, Second / Q000097:blood; D016896:Treatment Outcome
chemical_list: D001786:Blood Glucose; D007328:Insulin; D008055:Lipids; D010840:Phytosterols