title: Effect of creatine supplementation and drop-set resistance training in untrained aging adults.
abstract: To investigate the effects of creatine supplementation and drop-set resistance training in untrained aging adults. Participants were randomized to one of two groups: Creatine (CR: n=14, 7 females, 7 males; 58.0±3.0yrs, 0.1g/kg/day of creatine+0.1g/kg/day of maltodextrin) or Placebo (PLA: n=17, 7 females, 10 males; age: 57.6±5.0yrs, 0.2g/kg/day of maltodextrin) during 12weeks of drop-set resistance training (3days/week; 2 sets of leg press, chest press, hack squat and lat pull-down exercises performed to muscle fatigue at 80% baseline 1-repetition maximum [1-RM] immediately followed by repetitions to muscle fatigue at 30% baseline 1-RM).
  
  
  
  Prior to and following training and supplementation, assessments were made for body composition, muscle strength, muscle endurance, tasks of functionality, muscle protein catabolism and diet.
  
  
  
  Drop-set resistance training improved muscle mass, muscle strength, muscle endurance and tasks of functionality (p<0.05). The addition of creatine to drop-set resistance training significantly increased body mass (p=0.002) and muscle mass (p=0.007) compared to placebo. Males on creatine increased muscle strength (lat pull-down only) to a greater extent than females on creatine (p=0.005). Creatine enabled males to resistance train at a greater capacity over time compared to males on placebo (p=0.049) and females on creatine (p=0.012). Males on creatine (p=0.019) and females on placebo (p=0.014) decreased 3-MH compared to females on creatine.
  
  
  
  The addition of creatine to drop-set resistance training augments the gains in muscle mass from resistance training alone. Creatine is more effective in untrained aging males compared to untrained aging females.
authors: Faculty of Kinesiology and Health Studies, University of Regina, Canada.
authors: Sarah
authors: S
authors: Johannsmeyer
authors: Faculty of Kinesiology and Health Studies, University of Regina, Canada. Electronic address: Darren.Candow@uregina.ca.
authors: Darren G
authors: DG
authors: Candow
authors: Faculty of Kinesiology and Health Studies, University of Regina, Canada.
authors: C Markus
authors: CM
authors: Brahms
authors: College of Pharmacy and Nutrition, University of Saskatchewan, Canada.
authors: Deborah
authors: D
authors: Michel
authors: College of Pharmacy and Nutrition, University of Saskatchewan, Canada.
authors: Gordon A
authors: GA
authors: Zello
mesh_terms: D000375:Aging; D001823:Body Composition; D002170:Canada; D003401:Creatine / Q000008:administration & dosage*; D004032:Diet; D019587:Dietary Supplements; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D018763:Muscle Fatigue; D053580:Muscle Strength / Q000187:drug effects*; D018482:Muscle, Skeletal / Q000187:drug effects*; D009929:Organ Size; D010807:Physical Endurance / Q000187:drug effects; D055070:Resistance Training / Q000379:methods*; D012737:Sex Factors
chemical_list: D003401:Creatine
keywords: Endurance; Muscle mass; Muscle protein catabolism; Sarcopenia; Strength