title: T Cell Fates Zipped Up: How the Bach2 Basic Leucine Zipper Transcriptional Repressor Directs T Cell Differentiation and Function.
abstract: Recent data illustrate a key role for the transcriptional regulator bric-a-brac, tramtrack, and broad complex and cap'n'collar homology (Bach)2 in orchestrating T cell differentiation and function. Although Bach2 has a well-described role in B cell differentiation, emerging data show that Bach2 is a prototypical member of a novel class of transcription factors that regulates transcriptional activity in T cells at super-enhancers, or regions of high transcriptional activity. Accumulating data demonstrate specific roles for Bach2 in favoring regulatory T cell generation, restraining effector T cell differentiation, and potentiating memory T cell development. Evidence suggests that Bach2 regulates various facets of T cell function by repressing other key transcriptional regulators such as B lymphocyte-induced maturation protein 1. In this review, we examine our present understanding of the role of Bach2 in T cell function and highlight the growing evidence that this transcriptional repressor functions as a key regulator involved in maintenance of T cell quiescence, T cell subset differentiation, and memory T cell generation.
authors: Department of Microbiology and Immunology, McGill University, Montreal, Quebec H3A 2B4, Canada; Microbiome and Disease Tolerance Centre, McGill University, Montreal, Quebec H3A 2B4, Canada; martin.j.richer@mcgill.ca noah-butler@ouhsc.edu.
authors: Martin J
authors: 0000-0002-5737-3217
authors: MJ
authors: Richer
authors: Department of Microbiology and Immunology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104; and Graduate Program in Biosciences, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104.
authors: Mark L
authors: 0000-0002-5137-0576
authors: ML
authors: Lang
authors: Department of Microbiology and Immunology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104; and Graduate Program in Biosciences, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104 martin.j.richer@mcgill.ca noah-butler@ouhsc.edu.
authors: Noah S
authors: 0000-0002-1429-0796
authors: NS
authors: Butler
mesh_terms: D000818:Animals; D050976:Basic-Leucine Zipper Transcription Factors / Q000276:immunology*; D002454:Cell Differentiation / Q000276:immunology*; D006801:Humans; D008213:Lymphocyte Activation / Q000276:immunology; D013601:T-Lymphocytes / Q000166:cytology* / Q000276:immunology*
chemical_list: C491123:BACH2 protein, human; D050976:Basic-Leucine Zipper Transcription Factors