title: Antioxidant and Antihyperlipidemic Effects of Campomanesia adamantium O. Berg Root.
abstract: Campomanesia adamantium O. Berg, popularly known as guavira, has been used in Brazilian traditional medicine for reduction of serum lipid. The present study was carried out to investigate the antioxidant and antihyperlipidemic effects of Campomanesia adamantium root aqueous extract (ExCA). Phenolic compounds were quantified in the ExCA and gallic and ellagic acids were identified by HPLC. ExCA showed efficiency in 2,2-diphenyl-1-picrylhydrazyl free radical scavenging, with IC50 similar to butylhydroxytoluene control, and protected the erythrocytes against lipid peroxidation induced by 2,2'-azobis(2-methylpropionamidine) dihydrochloride, reducing generated malondialdehyde. Hyperlipidemic Wistar rats treated daily by gavage during eight weeks with ExCA (200 mg/kg of body weight) showed reduced serum level of total cholesterol and triglycerides, similar to normolipidemic rats and hyperlipidemic rats treated with simvastatin (30 mg/kg of body weight) and ciprofibrate (2 mg/kg of body weight). Moreover, the treatment with ExCA also decreased malondialdehyde serum level in the hyperlipidemic rats. The body weight and organ mass were unmodified by ExCA in hyperlipidemic rats, except an increase of liver mass; however, the hepatic enzymes, alanine aminotransferase and aspartate aminotransferase, were unchanged. Together, these results confirm the potential value of Campomanesia adamantium root for lowering lipid peroxidation and lipid serum level, improving risk factors for cardiometabolic diseases development.
authors: Federal University of Grande Dourados, Rodovia Dourados-Itahum, Km 12, 79804-970 Dourados, MS, Brazil.
authors: Priscilla Pereira de Toledo
authors: PP
authors: Espindola
authors: Federal University of Grande Dourados, Rodovia Dourados-Itahum, Km 12, 79804-970 Dourados, MS, Brazil.
authors: Paola Dos Santos
authors: 0000-0003-1019-1202
authors: Pdos S
authors: da Rocha
authors: Federal University of Mato Grosso do Sul, Cidade Universitária, s/n, 79070-900 Campo Grande, MS, Brazil.
authors: Carlos Alexandre
authors: 0000-0003-1231-9441
authors: CA
authors: Carollo
authors: Federal University of Grande Dourados, Rodovia Dourados-Itahum, Km 12, 79804-970 Dourados, MS, Brazil.
authors: Wanderlei Onofre
authors: 0000-0001-8079-3431
authors: WO
authors: Schmitz
authors: Federal University of Grande Dourados, Rodovia Dourados-Itahum, Km 12, 79804-970 Dourados, MS, Brazil.
authors: Zefa Valdivina
authors: 0000-0003-3344-3249
authors: ZV
authors: Pereira
authors: Federal University of Grande Dourados, Rodovia Dourados-Itahum, Km 12, 79804-970 Dourados, MS, Brazil.
authors: Maria do Carmo
authors: 0000-0001-7047-3848
authors: Mdo C
authors: Vieira
authors: Federal University of Grande Dourados, Rodovia Dourados-Itahum, Km 12, 79804-970 Dourados, MS, Brazil.
authors: Edson Lucas
authors: 0000-0002-6557-7914
authors: EL
authors: Dos Santos
authors: Federal University of Grande Dourados, Rodovia Dourados-Itahum, Km 12, 79804-970 Dourados, MS, Brazil.
authors: Kely
authors: 0000-0001-5764-2125
authors: K
authors: de Picoli Souza
mesh_terms: D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D001219:Aspartate Aminotransferases / Q000097:blood; D001713:Biphenyl Compounds / Q000737:chemistry; D002851:Chromatography, High Pressure Liquid; D016166:Free Radical Scavengers / Q000737:chemistry; D006461:Hemolysis / Q000187:drug effects; D006801:Humans; D000960:Hypolipidemic Agents / Q000494:pharmacology*; D020128:Inhibitory Concentration 50; D008055:Lipids / Q000097:blood; D008315:Malondialdehyde / Q000097:blood; D027822:Myrtaceae / Q000737:chemistry*; D010851:Picrates / Q000737:chemistry; D010936:Plant Extracts / Q000737:chemistry*; D018517:Plant Roots / Q000737:chemistry*; D017208:Rats, Wistar; D015430:Weight Gain / Q000187:drug effects
chemical_list: D000975:Antioxidants; D001713:Biphenyl Compounds; D016166:Free Radical Scavengers; D000960:Hypolipidemic Agents; D008055:Lipids; D010851:Picrates; D010936:Plant Extracts; D008315:Malondialdehyde; C004931:1,1-diphenyl-2-picrylhydrazyl; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase