title: Novel H2S Releasing Nanofibrous Coating for In Vivo Dermal Wound Regeneration.
abstract: Hydrogen sulfide (H2S), together with nitric oxide and carbon monoxide, has been recognized as an important gasotransmitter. It plays an essential physiological role in regulating cyto-protective signal process, and H2S-based therapy is considered as the next generation of promising therapeutic strategies for many biomedical applications, such as the treatment of cardiovascular disease. Through electrospinning of polycaprolactone (PCL) containing JK1, a novel pH-controllable H2S donor, nanofibers with H2S releasing function, PCL-JK1, are fabricated. This fibrous scaffold showed a pH-dependent H2S releasing behavior, i.e., lower pH induced greater and faster H2S release. In addition, the H2S release of JK1 was prolonged by the fibrous matrix as shown by decreased releasing rates compared to JK1 in solutions. In addition, in vitro studies indicated that PCL-JK1 exhibited excellent cyto-compatibility, similar to PCL fibers. Finally, we investigated PCL-JK1 as a wound dressing toward a cutaneous wound model in vivo and found that PCL-JK1 could significantly enhance the wound repair and regeneration compared with the control PCL scaffold, likely due to the release of H2S, which results in a broad range of physiologically protective functions toward the wound.
authors: School of Pharmaceutical Sciences, Key Laboratory of Biotechnology and Pharmaceutical Engineering, Wenzhou Medical University , Wenzhou, Zhejiang 325035, China.|Department of Chemistry and Biochemistry, University of South Carolina , Columbia, South Carolina 29208, United States.
authors: Jiang
authors: J
authors: Wu
authors: School of Pharmaceutical Sciences, Key Laboratory of Biotechnology and Pharmaceutical Engineering, Wenzhou Medical University , Wenzhou, Zhejiang 325035, China.
authors: Yi
authors: Y
authors: Li
authors: School of Pharmaceutical Sciences, Key Laboratory of Biotechnology and Pharmaceutical Engineering, Wenzhou Medical University , Wenzhou, Zhejiang 325035, China.
authors: Chaochao
authors: C
authors: He
authors: Department of Chemistry, Washington State University , Pullman, Washington 99164, United States.
authors: Jianming
authors: J
authors: Kang
authors: School of Pharmaceutical Sciences, Key Laboratory of Biotechnology and Pharmaceutical Engineering, Wenzhou Medical University , Wenzhou, Zhejiang 325035, China.
authors: Jingjing
authors: J
authors: Ye
authors: School of Pharmaceutical Sciences, Key Laboratory of Biotechnology and Pharmaceutical Engineering, Wenzhou Medical University , Wenzhou, Zhejiang 325035, China.
authors: Zecong
authors: Z
authors: Xiao
authors: School of Pharmaceutical Sciences, Key Laboratory of Biotechnology and Pharmaceutical Engineering, Wenzhou Medical University , Wenzhou, Zhejiang 325035, China.
authors: Jingjing
authors: J
authors: Zhu
authors: School of Pharmaceutical Sciences, Key Laboratory of Biotechnology and Pharmaceutical Engineering, Wenzhou Medical University , Wenzhou, Zhejiang 325035, China.
authors: Anqi
authors: A
authors: Chen
authors: Department of Chemistry and Biochemistry, University of South Carolina , Columbia, South Carolina 29208, United States.|486 Gallimore Dairy Rd, Greensboro, North Carolin 27409, United States.
authors: Sheng
authors: S
authors: Feng
authors: School of Pharmaceutical Sciences, Key Laboratory of Biotechnology and Pharmaceutical Engineering, Wenzhou Medical University , Wenzhou, Zhejiang 325035, China.
authors: Xiaokun
authors: X
authors: Li
authors: School of Pharmaceutical Sciences, Key Laboratory of Biotechnology and Pharmaceutical Engineering, Wenzhou Medical University , Wenzhou, Zhejiang 325035, China.
authors: Jian
authors: J
authors: Xiao
authors: Department of Chemistry, Washington State University , Pullman, Washington 99164, United States.
authors: Ming
authors: M
authors: Xian
authors: Department of Chemistry and Biochemistry, University of South Carolina , Columbia, South Carolina 29208, United States.
authors: Qian
authors: Q
authors: Wang
keywords: controlled release; electrospinning; fibrous materials; hydrogen sulfide; polycaprolactone; wound healing