title: In-vivo characterization of left-ventricle pressure-volume telemetry system in swine model.
abstract: We present in-vivo study related to the use of our implantable RF telemetry system for pressure-volume (PV) cardiac monitoring in a animal subject. We implant a commercial MEMS PV sensor into the subject's heart left-ventricle (LV), while the telemetry system is implanted outside of the heart and connected to the sensor with a 7-microwires tether. The RF telemetry system is suitable for commercial application in medium sized subjects, its total volume of 2.475cm(3) and a weight of 4.0g. Our designed system is 58 % smaller in volume, 44 % in weight and has a 55 % reduction in sampling power over the last reported research in PV telemetry. In-vivo data was captured in both an acute and a freely moving setting over a 24 hour period. We experimentally demonstrated viability of the methodology that includes the surgical procedure and real-time monitoring of the in-vivo data in a freely moving subject. Further improvements in catheter design will improve the data quality and safety of the subject. This real-time implantable technology allows for researchers to quantify cardiac pathologies by extracting real-time pressure-volume loops, wirelessly from within freely moving subjects.
authors: Department of Electrical and Computer Engineering at Western University, London, ON, Canada. kfricke@uwo.ca.
authors: Kyle
authors: 0000-0002-9036-4654
authors: K
authors: Fricke
authors: Transonic Scisense Inc., London, ON, Canada.
authors: Filip
authors: F
authors: Konecny
authors: Animal Care and Veterinary Services, Western University, London, ON, Canada.
authors: Alexander
authors: A
authors: El-Warrak
authors: Transonic Scisense Inc., London, ON, Canada.
authors: Chad
authors: C
authors: Hodgson
authors: Animal Care and Veterinary Services, Western University, London, ON, Canada.
authors: Heather
authors: H
authors: Cadieux-Pitre
authors: Animal Care and Veterinary Services, Western University, London, ON, Canada.
authors: Tracy
authors: T
authors: Hill
authors: Department of Electrical and Computer Engineering at Western University, London, ON, Canada.|ENSEA/University Cergy-Pontoise/CNRS, Pontoise, France.
authors: Robert
authors: R
authors: Sobot
mesh_terms: D000818:Animals; D002138:Calibration; D006352:Heart Ventricles; D009068:Movement; D019047:Phantoms, Imaging; D011312:Pressure; D019736:Prostheses and Implants; D013552:Swine; D013686:Telemetry / Q000295:instrumentation*; D013997:Time Factors; D059015:Wireless Technology
keywords: Biomedical telemetry; Cardiac; Conductance based catheter; Pathology; Pressure–volume; Swine heart