title: In Vitro Activity of 3-Triazeneindoles against Mycobacterium tuberculosis and Mycobacterium avium.
abstract: Among 230 target-synthesized indole-based compounds, seven 3-triazenoindoles showed MICs of 0.2 to 0.5 μg/ml against Mycobacterium tuberculosis strain H37Rv and isoniazid-resistant human isolate CN-40. The TU112 compound was active also against a dormant form of M. tuberculosis Some of these triazenoindoles were active against Mycobacterium avium, with MICs of 0.05 to 0.5 μg/ml. The selectivity indices (SI) for M. tuberculosis and M. avium were significantly higher than 10, making these compounds acceptable for the next testing step.
authors: Central Institute for Tuberculosis, Moscow, Russia TB-Stopper, Skolkovo, Moscow, Russia b.nikonenko@mail.ru.
authors: Boris V
authors: BV
authors: Nikonenko
authors: A. N. Nesmeyanov Institute of Organoelement Compounds of the Russian Academy of Sciences, Moscow, Russia.
authors: Albert
authors: A
authors: Kornienko
authors: Central Institute for Tuberculosis, Moscow, Russia.
authors: Konstantin
authors: K
authors: Majorov
authors: A. N. Nesmeyanov Institute of Organoelement Compounds of the Russian Academy of Sciences, Moscow, Russia.
authors: Pavel
authors: P
authors: Ivanov
authors: Central Institute for Tuberculosis, Moscow, Russia.
authors: Tatiana
authors: T
authors: Kondratieva
authors: Central Institute for Tuberculosis, Moscow, Russia.
authors: Maria
authors: M
authors: Korotetskaya
authors: Central Institute for Tuberculosis, Moscow, Russia TB-Stopper, Skolkovo, Moscow, Russia.
authors: Alexander S
authors: AS
authors: Apt
authors: A. N. Bach Institute of Biochemistry of the Russian Academy of Sciences, Moscow, Russia.
authors: Elena
authors: E
authors: Salina
authors: A. N. Nesmeyanov Institute of Organoelement Compounds of the Russian Academy of Sciences, Moscow, Russia TB-Stopper, Skolkovo, Moscow, Russia.
authors: Valeriya
authors: V
authors: Velezheva
mesh_terms: D000995:Antitubercular Agents / Q000737:chemistry / Q000494:pharmacology*; D004353:Drug Evaluation, Preclinical / Q000379:methods; D024881:Drug Resistance, Bacterial / Q000187:drug effects; D006801:Humans; D007211:Indoles / Q000737:chemistry / Q000494:pharmacology; D007538:Isoniazid / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D009162:Mycobacterium avium / Q000187:drug effects*; D009169:Mycobacterium tuberculosis / Q000187:drug effects* / Q000302:isolation & purification
chemical_list: D000995:Antitubercular Agents; D007211:Indoles; D007538:Isoniazid