title: A Comparative Study of Two Modalities, 4% Hydroquinone Versus 30% Salicylic Acid in Periorbital Hyperpigmentation and Assessment of Quality of Life Before and After Treatment.
abstract: BACKGROUND
  Periorbital hyperpigmentation (POH) is a common hyperpigmentary problem of the face, which can be psychologically distressing and it can influence an individual's quality of life. However, this condition has received less attention in literature.
  
  
  OBJECTIVE
  To study the clinico-etiological features and the effect of two therapeutic modalities on the quality of life in patients of POH before and after treatment.
  
  
  METHODS
  Fifty patients attending the outpatient clinic of Dermatology Department, with clinically evident POH were included. All patients were divided randomly into two groups of 25 each and one group was treated with 4% hydroquinone and another group with 30% salicylic acid for 12 weeks. Assessment with visual analog scale (VAS) was done at 4, 6, and 12 weeks, and outcome of the patients was analyzed statistically.
  
  
  RESULTS
  Majority of the cases, i.e. 26 (52%) were in the age group of 20-30 years. Females comprised 74% of the study population. On VAS, most of the patients showed mild improvement (10-30%) at 12 weeks of treatment in both the groups. Separately, both the treatments significantly improved the dermatological life quality index of the patients although there was no significant difference found between the two groups.
  
  
  CONCLUSIONS
  POH is less responsive to standard treatments due to its multifactorial etiology and deposition of melanin in both dermis and epidermis. However, even the mild to moderate improvement in appearance can cause an improvement in the quality of life of the patients.
authors: Department of Dermatology and Venereology, Maulana Azad Medical College and Associated Hospitals, New Delhi, India.
authors: Rashmi
authors: R
authors: Ranjan
authors: Department of Dermatology and Venereology, Maulana Azad Medical College and Associated Hospitals, New Delhi, India.
authors: Rashmi
authors: R
authors: Sarkar
authors: Department of Dermatology and Venereology, Maulana Azad Medical College and Associated Hospitals, New Delhi, India.
authors: Vijay Kumar
authors: VK
authors: Garg
authors: Department of Dermatology and Venereology, Maulana Azad Medical College and Associated Hospitals, New Delhi, India.
authors: Tanvi
authors: T
authors: Gupta
keywords: Hydroquinone; periorbital hyperpigmentation; salicylic acid