title: Hedgehog Signalling in the Embryonic Mouse Thymus.
abstract: T cells develop in the thymus, which provides an essential environment for T cell fate specification, and for the differentiation of multipotent progenitor cells into major histocompatibility complex (MHC)-restricted, non-autoreactive T cells. Here we review the role of the Hedgehog signalling pathway in T cell development, thymic epithelial cell (TEC) development, and thymocyte-TEC cross-talk in the embryonic mouse thymus during the last week of gestation.
authors: Immunobiology Section, UCL Institute of Child Health, London WC1N 1EH, UK.
authors: Alessandro
authors: A
authors: Barbarulo
authors: Immunobiology Section, UCL Institute of Child Health, London WC1N 1EH, UK.
authors: Ching-In
authors: CI
authors: Lau
authors: Immunobiology Section, UCL Institute of Child Health, London WC1N 1EH, UK.
authors: Konstantinos
authors: K
authors: Mengrelis
authors: Immunobiology Section, UCL Institute of Child Health, London WC1N 1EH, UK.
authors: Susan
authors: S
authors: Ross
authors: Immunobiology Section, UCL Institute of Child Health, London WC1N 1EH, UK.
authors: Anisha
authors: A
authors: Solanki
authors: Immunobiology Section, UCL Institute of Child Health, London WC1N 1EH, UK.
authors: José Ignacio
authors: JI
authors: Saldaña
authors: Immunobiology Section, UCL Institute of Child Health, London WC1N 1EH, UK.
authors: Tessa
authors: T
authors: Crompton
keywords: Gli1; Gli2; Gli3; Hedgehog; Ihh; Shh; T cell development; thymic epithelial cell (TEC); thymus