title: Association of serum adiponectin concentration with aortic arterial stiffness in chronic kidney disease: from the KNOW-CKD study.
abstract: BACKGROUND
  High serum adiponectin levels predict all-cause and cardiovascular mortality in chronic kidney disease (CKD). However, the relationship between serum adiponectin concentration and arterial stiffness in CKD is not well established. The aim of this study was to assess this relationship by measuring pulse wave velocity (PWV) in CKD patients.
  
  
  METHODS
  Serum adiponectin concentration was measured in 716 CKD patients in the prospective KoreaN cohort study for Outcome in patients With Chronic Kidney Disease. The study group consisted of 415 men and 301 women; mean age was 53.1 years, and baseline estimated glomerular filtration rate (eGFR) was 51 ± 29 ml/min per 1.73 m2. Heart to femoral PWV (hfPWV) and mean brachial to ankle PWV (baPWV) served as indicators of aortic artery stiffness and arterial stiffness, respectively.
  
  
  RESULTS
  Increasing quartiles of serum adiponectin levels were associated with women, lower eGFRs and body mass indices, and higher urinary albumin-creatinine ratios. Serum adiponectin concentration also correlated with hfPWV and mean baPWV, even after adjusting for age and sex. It independently associated with hfPWV (B 0.028; 95 % confidence interval, 0.004-0.051; P = 0.020) but not mean baPWV in a multivariable linear regression analysis. In a multivariable logistic regression analysis, it correlated significantly with the highest quartile of hfPWVs but not mean baPWVs.
  
  
  CONCLUSIONS
  The independent and significant correlation of serum adiponectin concentration with hfPWV in CKD patients implicates adiponectin in CKD-associated aortic stiffness.
authors: Department of Internal Medicine, Chonnam National University Medical School, 42 Jebongro, Gwangju, 501-757, Korea.
authors: Chang Seong
authors: CS
authors: Kim
authors: Department of Internal Medicine, Chonnam National University Medical School, 42 Jebongro, Gwangju, 501-757, Korea.
authors: Eun Hui
authors: EH
authors: Bae
authors: Department of Internal Medicine, Chonnam National University Medical School, 42 Jebongro, Gwangju, 501-757, Korea.
authors: Seong Kwon
authors: SK
authors: Ma
authors: Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Korea.|Department of Biomedical Science, Seoul National University Graduate School, Seoul, Korea.|Cancer Research Institute, Seoul National University, Seoul, Korea.
authors: Sue K
authors: SK
authors: Park
authors: Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Korea.
authors: Ju Yeon
authors: JY
authors: Lee
authors: Department of Internal Medicine, Gil Hospital, Gachon University, Incheon, Korea.
authors: Wookyung
authors: W
authors: Chung
authors: Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University, Seoul, Korea.
authors: Kyubeck
authors: K
authors: Lee
authors: Department of Internal Medicine, Pusan Paik Hospital, Inje University, Busan, Korea.
authors: Yeong Hoon
authors: YH
authors: Kim
authors: Department of Internal Medicine, Seoul National University, Seoul, Korea.
authors: Kook-Hwan
authors: KH
authors: Oh
authors: Department of Internal Medicine, Seoul National University, Seoul, Korea.
authors: Curie
authors: C
authors: Ahn
authors: Department of Internal Medicine, Chonnam National University Medical School, 42 Jebongro, Gwangju, 501-757, Korea. skimw@chonnam.ac.kr.
authors: Soo Wan
authors: SW
authors: Kim
mesh_terms: D052242:Adiponectin / Q000097:blood*; D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D002318:Cardiovascular Diseases / Q000209:etiology / Q000503:physiopathology; D016009:Chi-Square Distribution; D003430:Cross-Sectional Studies; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D007668:Kidney / Q000503:physiopathology; D016014:Linear Models; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D011379:Prognosis; D011446:Prospective Studies; D063177:Pulse Wave Analysis; D051436:Renal Insufficiency, Chronic / Q000097:blood* / Q000150:complications / Q000175:diagnosis / Q000503:physiopathology*; D056910:Republic of Korea; D012307:Risk Factors; D013997:Time Factors; D015854:Up-Regulation; D059289:Vascular Stiffness
chemical_list: C499918:ADIPOQ protein, human; D052242:Adiponectin; D015415:Biomarkers
keywords: Adiponectin; Arterial stiffness; Chronic kidney disease; Pulse wave velocity