title: Penicilloitins A and B, new antimicrobial fatty acid esters from a marine endophytic Penicillium species.
abstract: Two new antimicrobial fatty acid esters, penicilloitins A and B (1 and 2), along with α-cyclopiazonic acid (3), tryptamine (4) and indole-3-carbaldehyde (5), were isolated from mycelial extracts and the culture broth of a marine endophytic Penicillium species and their structures established by spectroscopic techniques including 1D (1H NMR and 13C NMR) and 2D NMR (COSY, multiplicity-edited HSQC, and HMBC) as well as HRESIMS. Of these compounds, 1, 3 and 4 displayed modest antimicrobial activity.
authors: Samar S A
authors: SS
authors: Mourshid
authors: Jihan M
authors: JM
authors: Badr
authors: April L
authors: AL
authors: Risinger
authors: Susan L
authors: SL
authors: Mooberry
authors: Diaa T A
authors: DT
authors: Youssef
mesh_terms: D000890:Anti-Infective Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002176:Candida albicans / Q000187:drug effects; D066241:Carbon-13 Magnetic Resonance Spectroscopy; D004354:Drug Screening Assays, Antitumor; D004926:Escherichia coli / Q000187:drug effects; D004952:Esters / Q000737:chemistry; D005227:Fatty Acids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006367:HeLa Cells; D006801:Humans; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D010407:Penicillium / Q000737:chemistry*; D066244:Proton Magnetic Resonance Spectroscopy; D021241:Spectrometry, Mass, Electrospray Ionization; D013211:Staphylococcus aureus / Q000187:drug effects
chemical_list: D000890:Anti-Infective Agents; D004952:Esters; D005227:Fatty Acids; C000615695:penicilloitin A