title: Genetic effects of sterol regulatory element binding proteins and fatty acid-binding protein4 on the fatty acid composition of Korean cattle (Hanwoo).
abstract: OBJECTIVE
  This study identifies single-nucleotide polymorphisms (SNP) or gene combinations that affect the flavor and quality of Korean cattle (Hanwoo) by using the SNP Harvester method.
  
  
  METHODS
  Four economic traits (oleic acid [C18:1], saturated fatty acids), monounsaturated fatty acids, and marbling score) were adjusted for environmental factors in order to focus solely on genetic effects. The SNP Harvester method was used to investigate gene combinations (two-way gene interactions) associated with these economic traits. Further, a multifactor dimensionality reduction method was used to identify superior genotypes in gene combinations.
  
  
  RESULTS
  Table 3 to 4 show the analysis results for differences between superior genotypes and others for selected major gene combinations using the multifactor dimensionality reduction method. Environmental factors were adjusted for in order to evaluate only the genetic effect. Table 5 shows the adjustment effect by comparing the accuracy before and after correction in two-way gene interactions.
  
  
  CONCLUSIONS
  The g.3977-325 T>C and (g.2988 A>G, g.3977-325 T>C) combinations of fatty acid-binding protein4 were the superior gene, and the superior genotype combinations across all economic traits were the CC genotype at g.3977-325 T>C and the AACC, GACC, GGCC genotypes of (g.2988 A>G, g.3977-325 T>C).
authors: Livestock Research institute, Yeongju 750-871, Korea.
authors: Dong-Yep
authors: DY
authors: Oh
authors: Department of Statistics, Yeungnam University, Gyeongsan 712-749, Korea.
authors: Jea-Young
authors: JY
authors: Lee
authors: Department of Statistics, Yeungnam University, Gyeongsan 712-749, Korea.
authors: Ji-Eun
authors: JE
authors: Jang
authors: Department of Civil and Environmental Engineering, National University of Singapore, Singapore 117576, Singapore.
authors: Seung-Uk
authors: SU
authors: Lee
keywords: Fatty Acid-binding Protein4 (FABP4); Hanwoo; SNP Harvester; Single-Nucleotide Polymorphism (SNP); Sterol Regulatory Element Binding Proteins (SREBPs)