title: Specific patterns of laryngeal electromyography during wakefulness are associated to sleep disordered breathing and nocturnal stridor in multiple system atrophy.
abstract: Nocturnal stridor and respiratory abnormalities are important features of multiple system atrophy (MSA) with relevance to patient survival, and they are detected and evaluated mainly through video-polysomnography (video-PSG). Diurnal laryngoscopy seems to yield abnormal findings only in the presence of significant vocal cord (VC) dysfunction.
  
  
  
  To assess whether specific electrophysiological patterns of diurnal EMG of VC muscles may indicate nocturnal stridor or respiratory dysfunctions in MSA patients.
  
  
  
  Seventeen patients with probable MSA were examined. A full-night video-PSG to collect standard breathing parameters (apnea/hypopnea index, mean HbSAO2, oxygen desaturation index, total sleep time with HbSaO2below 90%) was performed in all the patients. Laryngoscopy and EMG investigation of adductor (thyroarytenoid-TA) and abductor (posterior cricoarytenoid-PCA) muscles of the VCs were also performed.
  
  
  
  Both the laryngeal EMG abnormalities (based on MUAP analysis and kinesiologic EMG investigation of VC muscles) and the laryngoscopic alterations correlated with video-PSG respiratory abnormalities. Specific patterns of EMG findings were consistently found in MSA subjects with nocturnal stridor detected at PSG. In particular, the following EMG findings were related to the severity of breathing abnormalities and the presence of stridor on video-PSG: neurogenic pattern on MUAP analysis of the PCA, paradoxical activation of the TA during inspiration and tonic EMG activity of the TA during quiet breathing.
  
  
  
  Electromyographic/kinesiologic investigation of VC muscles during wakefulness provides additional information on the pathophysiology of the respiratory abnormalities in MSA patients that could be useful for guiding the choice of the best appropriate treatment and care.
authors: Spinal and Brainstem Reflexes Laboratory, C. Mondino National Neurological Institute, University of Pavia, Pavia, Italy. Electronic address: enrico.alfonsi@mondino.it.
authors: E
authors: E
authors: Alfonsi
authors: Sleep Disorders Center, C. Mondino National Neurological Institute, University of Pavia, Pavia, Italy.
authors: M
authors: M
authors: Terzaghi
authors: Department of Experimental Biomedicine and Clinical Neurosciences (BioNec), University of Palermo, Palermo, Italy.
authors: G
authors: G
authors: Cosentino
authors: Spinal and Brainstem Reflexes Laboratory, C. Mondino National Neurological Institute, University of Pavia, Pavia, Italy.
authors: C
authors: C
authors: Tassorelli
authors: Sleep Disorders Center, C. Mondino National Neurological Institute, University of Pavia, Pavia, Italy.
authors: R
authors: R
authors: Manni
authors: Parkinson's Disease Center, C. Mondino National Neurological Institute, University of Pavia, Pavia, Italy.
authors: N
authors: N
authors: Pozzi
authors: Spinal and Brainstem Reflexes Laboratory, C. Mondino National Neurological Institute, University of Pavia, Pavia, Italy.
authors: R
authors: R
authors: De Icco
authors: Department of Otorhinolaryngology, IRCCS Policlinico San Matteo Foundation, University of Pavia, Pavia, Italy.
authors: G
authors: G
authors: Bertino
authors: Spinal and Brainstem Reflexes Laboratory, C. Mondino National Neurological Institute, University of Pavia, Pavia, Italy.
authors: M
authors: M
authors: Todisco
authors: Spinal and Brainstem Reflexes Laboratory, C. Mondino National Neurological Institute, University of Pavia, Pavia, Italy.
authors: E
authors: E
authors: Alvisi
authors: Spinal and Brainstem Reflexes Laboratory, C. Mondino National Neurological Institute, University of Pavia, Pavia, Italy.
authors: M
authors: M
authors: Fresia
authors: Parkinson's Disease Center, C. Mondino National Neurological Institute, University of Pavia, Pavia, Italy.
authors: C
authors: C
authors: Pacchetti
authors: Parkinson's Disease Center, C. Mondino National Neurological Institute, University of Pavia, Pavia, Italy.
authors: R
authors: R
authors: Zangaglia
authors: Spinal and Brainstem Reflexes Laboratory, C. Mondino National Neurological Institute, University of Pavia, Pavia, Italy.
authors: P
authors: P
authors: Prunetti
authors: Spinal and Brainstem Reflexes Laboratory, C. Mondino National Neurological Institute, University of Pavia, Pavia, Italy.
authors: A
authors: A
authors: Moglia
mesh_terms: D000368:Aged; D002940:Circadian Rhythm / Q000502:physiology*; D004576:Electromyography; D005260:Female; D006801:Humans; D007821:Laryngeal Muscles / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D019578:Multiple System Atrophy / Q000150:complications*; D017286:Polysomnography; D012135:Respiratory Sounds / Q000503:physiopathology*; D012720:Severity of Illness Index; D012891:Sleep Apnea Syndromes / Q000209:etiology*; D014851:Wakefulness / Q000502:physiology*
keywords: Laryngeal electromyography; Laryngoscopy; Multiple system atrophy; Nocturnal stridor; Sleep disordered breathing