title: Defining myocardial tissue abnormalities in end-stage renal failure with cardiac magnetic resonance imaging using native T1 mapping.
abstract: Noninvasive quantification of myocardial fibrosis in end-stage renal disease is challenging. Gadolinium contrast agents previously used for cardiac magnetic resonance imaging (MRI) are contraindicated because of an association with nephrogenic systemic fibrosis. In other populations, increased myocardial native T1 times on cardiac MRI have been shown to be a surrogate marker of myocardial fibrosis. We applied this method to 33 incident hemodialysis patients and 28 age- and sex-matched healthy volunteers who underwent MRI at 3.0T. Native T1 relaxation times and feature tracking-derived global longitudinal strain as potential markers of fibrosis were compared and associated with cardiac biomarkers. Left ventricular mass indices were higher in the hemodialysis than the control group. Global, Septal and midseptal T1 times were all significantly higher in the hemodialysis group (global T1 hemodialysis 1171 ± 27 ms vs. 1154 ± 32 ms; septal T1 hemodialysis 1184 ± 29 ms vs. 1163 ± 30 ms; and midseptal T1 hemodialysis 1184 ± 34 ms vs. 1161 ± 29 ms). In the hemodialysis group, T1 times correlated with left ventricular mass indices. Septal T1 times correlated with troponin and electrocardiogram-corrected QT interval. The peak global longitudinal strain was significantly reduced in the hemodialysis group (hemodialysis -17.7±5.3% vs. -21.8±6.2%). For hemodialysis patients, the peak global longitudinal strain significantly correlated with left ventricular mass indices (R = 0.426), and a trend was seen for correlation with galectin-3, a biomarker of cardiac fibrosis. Thus, cardiac tissue properties of hemodialysis patients consistent with myocardial fibrosis can be determined noninvasively and associated with multiple structural and functional abnormalities.
authors: Institute of Cardiovascular and Medical Sciences, BHF Glasgow Cardiovascular Research Centre, University of Glasgow, Scotland, UK; University of Dundee, Division of Cardiovascular & Diabetes Medicine, Dundee, Scotland, UK. Electronic address: e.rutherford@dundee.ac.uk.
authors: Elaine
authors: E
authors: Rutherford
authors: Institute of Cardiovascular and Medical Sciences, BHF Glasgow Cardiovascular Research Centre, University of Glasgow, Scotland, UK.
authors: Mohammed A
authors: MA
authors: Talle
authors: Institute of Cardiovascular and Medical Sciences, BHF Glasgow Cardiovascular Research Centre, University of Glasgow, Scotland, UK.
authors: Kenneth
authors: K
authors: Mangion
authors: Institute of Cardiovascular and Medical Sciences, BHF Glasgow Cardiovascular Research Centre, University of Glasgow, Scotland, UK.
authors: Elizabeth
authors: E
authors: Bell
authors: Institute of Cardiovascular and Medical Sciences, BHF Glasgow Cardiovascular Research Centre, University of Glasgow, Scotland, UK.
authors: Samuli M
authors: SM
authors: Rauhalammi
authors: Institute of Cardiovascular and Medical Sciences, BHF Glasgow Cardiovascular Research Centre, University of Glasgow, Scotland, UK.
authors: Giles
authors: G
authors: Roditi
authors: Institute of Cardiovascular and Medical Sciences, BHF Glasgow Cardiovascular Research Centre, University of Glasgow, Scotland, UK.
authors: Christie
authors: C
authors: McComb
authors: Institute of Cardiovascular and Medical Sciences, BHF Glasgow Cardiovascular Research Centre, University of Glasgow, Scotland, UK.
authors: Aleksandra
authors: A
authors: Radjenovic
authors: Institute of Cardiovascular and Medical Sciences, BHF Glasgow Cardiovascular Research Centre, University of Glasgow, Scotland, UK.
authors: Paul
authors: P
authors: Welsh
authors: Institute of Cardiovascular and Medical Sciences, BHF Glasgow Cardiovascular Research Centre, University of Glasgow, Scotland, UK.
authors: Rosemary
authors: R
authors: Woodward
authors: University of Dundee, Division of Cardiovascular & Diabetes Medicine, Dundee, Scotland, UK.
authors: Allan D
authors: AD
authors: Struthers
authors: Institute of Cardiovascular and Medical Sciences, BHF Glasgow Cardiovascular Research Centre, University of Glasgow, Scotland, UK.
authors: Alan G
authors: AG
authors: Jardine
authors: Institute of Cardiovascular and Medical Sciences, BHF Glasgow Cardiovascular Research Centre, University of Glasgow, Scotland, UK.
authors: Rajan K
authors: RK
authors: Patel
authors: Institute of Cardiovascular and Medical Sciences, BHF Glasgow Cardiovascular Research Centre, University of Glasgow, Scotland, UK.
authors: Colin
authors: C
authors: Berry
authors: Institute of Cardiovascular and Medical Sciences, BHF Glasgow Cardiovascular Research Centre, University of Glasgow, Scotland, UK.
authors: Patrick B
authors: PB
authors: Mark
mesh_terms: D000368:Aged; D015415:Biomarkers / Q000097:blood; D001706:Biopsy; D009202:Cardiomyopathies / Q000097:blood / Q000000981:diagnostic imaging* / Q000209:etiology / Q000473:pathology; D003287:Contrast Media / Q000008:administration & dosage / Q000009:adverse effects; D004562:Electrocardiography / Q000379:methods; D005260:Female; D005355:Fibrosis; D005682:Gadolinium / Q000008:administration & dosage / Q000009:adverse effects; D037502:Galectin 3 / Q000097:blood; D006321:Heart / Q000000981:diagnostic imaging* / Q000503:physiopathology; D006801:Humans; D007676:Kidney Failure, Chronic / Q000150:complications* / Q000628:therapy; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008875:Middle Aged; D009206:Myocardium / Q000473:pathology*; D020097:Natriuretic Peptide, Brain / Q000097:blood; D010446:Peptide Fragments / Q000097:blood; D006435:Renal Dialysis / Q000009:adverse effects; D020107:Troponin T / Q000097:blood
chemical_list: D015415:Biomarkers; D003287:Contrast Media; D037502:Galectin 3; D010446:Peptide Fragments; D020107:Troponin T; C109794:pro-brain natriuretic peptide (1-76); D020097:Natriuretic Peptide, Brain; D005682:Gadolinium
keywords: cardiovascular disease; fibrosis; hemodialysis