title: Curcumin improves atorvastatin-induced myotoxicity in rats: Histopathological and biochemical evidence.
abstract: Atorvastatin is considered to be one of the most commonly used of all statins anti-hyperlipidemic drugs despite the fact that there is much controversy about its safety. Its therapeutic use becomes severely limited by the hazards of inducing myotoxicity. Curcumin is one of the safe spices that have chemoprotection and cytoprotection effects against endogenous and exogenous noxious stimuli. This study investigates the effect of curcumin on atorvastatin sub-chronic use-induced myotoxicity in rats by the assessment of serum creatinine phosphokinase, lactic acid dehydrogenase, myoglobin, troponin, potassium, creatinine, and histopathological changes of skeletal, smooth, and cardiac muscles by light and electron microscope examination. Eighty adult albino rats were divided into four groups; each group consists of 20 rats. The control group received water, the second group received atorvastatin, the third group received curcumin, and the fourth group received curcumin with atorvastatin for 90 days by gastric gavage. The prolonged use of atorvastatin induced significant abnormalities of all myotoxicity biomarkers associated with histopathological and ultrastructural changes in the different types of the muscles. Co-administration of curcumin with sub-chronic use of atorvastatin led to an improvement in myotoxicity manifestations.
authors: Department of Forensic Medicine and Clinical Toxicology, College of Medicine, Taif University, Suez Canal University, Egypt.
authors: Said Said
authors: SS
authors: Elshama
authors: Department of Pathology, College of Medicine, Taif University, GEBRI, University of Sadat City, Egypt elkenawyay@yahoo.com.
authors: Ayman El-Meghawry
authors: AE
authors: El-Kenawy
authors: Department of Anatomy, College of Medicine, Taif University, Al-Azhar University, Egypt.
authors: Hosam-Eldin Hussein
authors: HH
authors: Osman
mesh_terms: D000818:Animals; D000069059:Atorvastatin / Q000009:adverse effects*; D015415:Biomarkers / Q000378:metabolism; D003404:Creatinine / Q000378:metabolism; D003474:Curcumin / Q000494:pharmacology*; D019610:Cytoprotection / Q000187:drug effects*; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D009132:Muscles / Q000187:drug effects / Q000378:metabolism; D009211:Myoglobin / Q000378:metabolism; D011188:Potassium / Q000378:metabolism; D051381:Rats; D014336:Troponin / Q000378:metabolism
chemical_list: D015415:Biomarkers; D009211:Myoglobin; D014336:Troponin; D000069059:Atorvastatin; D003404:Creatinine; D007770:L-Lactate Dehydrogenase; D003474:Curcumin; D011188:Potassium
keywords: atorvastatin; curcumin; myotoxicity