title: Functional dissociation between anterior temporal lobe and inferior frontal gyrus in the processing of dynamic body expressions: Insights from behavioral variant frontotemporal dementia.
abstract: Several brain regions are involved in the processing of emotional stimuli, however, the contribution of specific regions to emotion perception is still under debate. To investigate this issue, we combined behavioral testing, structural and resting state imaging in patients diagnosed with behavioral variant frontotemporal dementia (bvFTD) and age matched controls, with task-based functional imaging in young, healthy volunteers. As expected, bvFTD patients were impaired in emotion detection as well as emotion categorization tasks, testing dynamic emotional body expressions as stimuli. Interestingly, their performance in the two tasks correlated with gray matter volume in two distinct brain regions, the left anterior temporal lobe for emotion detection and the left inferior frontal gyrus (IFG) for emotion categorization. Confirming this observation, multivoxel pattern analysis in healthy volunteers demonstrated that both ROIs contained information for emotion detection, but that emotion categorization was only possible from the pattern in the IFG. Furthermore, functional connectivity analysis showed reduced connectivity between the two regions in bvFTD patients. Our results illustrate that the mentalizing network and the action observation network perform distinct tasks during emotion processing. In bvFTD, communication between the networks is reduced, indicating one possible cause underlying the behavioral symptoms. Hum Brain Mapp 37:4472-4486, 2016. © 2016 Wiley Periodicals, Inc.
authors: Laboratory for Translational Neuropsychiatry, Division of Psychiatry, Department of Neurosciences, KU Leuven, Belgium.
authors: Jan
authors: 0000-0002-3885-9983
authors: J
authors: Jastorff
authors: Laboratory for Translational Neuropsychiatry, Division of Psychiatry, Department of Neurosciences, KU Leuven, Belgium.|Department of Old Age Psychiatry, University Hospitals Leuven, Belgium.
authors: Francois-Laurent
authors: FL
authors: De Winter
authors: Laboratory for Translational Neuropsychiatry, Division of Psychiatry, Department of Neurosciences, KU Leuven, Belgium.|Department of Old Age Psychiatry, University Hospitals Leuven, Belgium.
authors: Jan
authors: J
authors: Van den Stock
authors: Laboratory for Cognitive Neurology, Department of Neurosciences, KU Leuven, Belgium.|Department of Neurology, University Hospitals Leuven, Leuven, Belgium.
authors: Rik
authors: R
authors: Vandenberghe
authors: Section for Computational Sensomotorics, Department of Cognitive Neurology, University Clinic Tübingen, Tübingen, 72076, Germany.
authors: Martin A
authors: MA
authors: Giese
authors: Laboratory for Translational Neuropsychiatry, Division of Psychiatry, Department of Neurosciences, KU Leuven, Belgium.|Department of Old Age Psychiatry, University Hospitals Leuven, Belgium.
authors: Mathieu
authors: M
authors: Vandenbulcke
mesh_terms: D000328:Adult; D000368:Aged; D001931:Brain Mapping; D004644:Emotions / Q000502:physiology; D005260:Female; D057180:Frontotemporal Dementia / Q000000981:diagnostic imaging / Q000503:physiopathology* / Q000523:psychology; D066128:Gray Matter / Q000000981:diagnostic imaging / Q000502:physiology / Q000503:physiopathology; D006801:Humans; D007600:Judgment; D008279:Magnetic Resonance Imaging; D008297:Male; D009483:Neuropsychological Tests; D009929:Organ Size; D010364:Pattern Recognition, Visual / Q000502:physiology; D017397:Prefrontal Cortex / Q000000981:diagnostic imaging / Q000502:physiology / Q000503:physiopathology*; D012146:Rest; D012938:Social Perception; D013702:Temporal Lobe / Q000000981:diagnostic imaging / Q000502:physiology / Q000503:physiopathology*; D055815:Young Adult
keywords: connectivity; emotion; frontotemporal dementia; functional imaging; mentalizing