title: Zika Virus-Induced Antibody Response Enhances Dengue Virus Serotype 2 Replication In Vitro.
abstract: Zika virus has emerged in the Americas, where dengue virus is endemic. Among the 4 serotypes of dengue virus, antibody-dependent enhancement is thought to enhance viral replication and disease severity. Reports suggest that anti-dengue virus antibody may enhance Zika virus replication. We investigated whether Zika virus antibodies enhance dengue virus replication, by exposing C57Bl/6 mice to Zika virus. Polyclonal serum was verified for strong Zika virus-neutralizing, dengue virus-subneutralizing capacity. Then we determined the enhancement capabilities of Zika virus-immune serum for dengue virus in vitro. We showed that Zika virus antibodies have the ability to enhance dengue virus infections, which is important, because in many Zika virus-affected areas, dengue virus is expected to remain endemic.
authors: Department of Pathobioloigcal Sciences, School of Veterinary Medicine, Louisiana State University, Baton Rouge.
authors: Anna B
authors: AB
authors: Kawiecki
authors: Department of Pathobioloigcal Sciences, School of Veterinary Medicine, Louisiana State University, Baton Rouge.
authors: Rebecca C
authors: RC
authors: Christofferson
mesh_terms: D000569:Americas; D000818:Animals; D057134:Antibodies, Neutralizing / Q000097:blood / Q000276:immunology; D000914:Antibodies, Viral / Q000097:blood / Q000276:immunology*; D000917:Antibody Formation / Q000276:immunology*; D019067:Antibody-Dependent Enhancement / Q000276:immunology*; D002460:Cell Line; D003715:Dengue / Q000097:blood / Q000276:immunology / Q000821:virology; D003716:Dengue Virus / Q000235:genetics* / Q000276:immunology; D005260:Female; D006801:Humans; D051379:Mice; D008810:Mice, Inbred C57BL; D009500:Neutralization Tests / Q000379:methods; D065288:Serogroup; D014709:Vero Cells; D010948:Viral Plaque Assay / Q000379:methods; D014779:Virus Replication / Q000235:genetics*; D000071244:Zika Virus / Q000276:immunology*; D000071243:Zika Virus Infection / Q000097:blood / Q000276:immunology / Q000821:virology
chemical_list: D057134:Antibodies, Neutralizing; D000914:Antibodies, Viral
keywords: Zika; antibody; antibody dependent enhancement; dengue; enhancement; plaque reduction neutralization test (PRNT)