title: Plasma Kinetics of Th1, Th2 and Th17 Cytokines in Polymyositis Related to Chronic Graft-versus-Host Disease.
abstract: We herein describe a case of myelodysplastic syndrome with chronic graft-versus-host disease (cGVHD)-related polymyositis. On approximately day 1,570 post HLA-identical sibling bone marrow transplant, the patient presented with a fever, myalgia and liver dysfunction. A muscle biopsy revealed destruction of the muscle fibers and infiltration of CD20(+) B cells and CD4(+) and CD8(+) T cells, and a liver biopsy confirmed the findings of cGVHD. An analysis of plasma cytokine profiles indicated elevation of not only T-helper (Th)1 and Th2, but also Th17 cytokines. Increases in these cytokines in addition to the invasion of inflammatory cells might be associated with the pathophysiology of cGVHD involving the muscle and liver.
authors: Hematology, Graduate School of Medicine, Osaka City University, Japan.
authors: Shiro
authors: S
authors: Koh
authors: Hideo
authors: H
authors: Koh
authors: Yasuhiro
authors: Y
authors: Nakashima
authors: Takako
authors: T
authors: Katayama
authors: Manami
authors: M
authors: Sakabe
authors: Hiroshi
authors: H
authors: Okamura
authors: Takuro
authors: T
authors: Yoshimura
authors: Satoru
authors: S
authors: Nanno
authors: Mitsutaka
authors: M
authors: Nishimoto
authors: Yoshiki
authors: Y
authors: Hayashi
authors: Takahiko
authors: T
authors: Nakane
authors: Hirohisa
authors: H
authors: Nakamae
authors: Masahiko
authors: M
authors: Ohsawa
authors: Masayuki
authors: M
authors: Hino
mesh_terms: D000328:Adult; D016026:Bone Marrow Transplantation; D018414:CD8-Positive T-Lymphocytes; D005260:Female; D006086:Graft vs Host Disease / Q000000981:diagnostic imaging / Q000276:immunology*; D006801:Humans; D020381:Interleukin-17 / Q000276:immunology*; D008297:Male; D018417:Th1 Cells / Q000276:immunology*; D058504:Th17 Cells / Q000276:immunology*; D014184:Transplantation, Homologous
chemical_list: D020381:Interleukin-17