title: Isolated ileal ganglioneuromatosis in an 11-year-old boy: Case report and review of literature.
abstract: Ganglioneuromatous proliferation in the gastrointestinal tract is a rare occurrence and is usually associated with specific syndrome complexes such as multiple endocrine neoplasia Type 2B or von Recklinghausen's disease. We report here a case of diffuse intestinal ganglioneuromatosis, presenting as intestinal obstruction and chronic constipation in an 11-year-old boy. Sporadic cases of intestinal ganglioneuromatosis in the absence of any systemic manifestations are a very rare cause of enteric motility disorders in childhood, and we discuss the pathological and clinical significance of this finding. Histopathological identification of this uncommon cause of a common pediatric problem is important since the condition is amenable to surgical treatment.
authors: Department of Pathology, AMRI Hospitals, Kolkata, West Bengal, India.
authors: Subhashis
authors: S
authors: Mitra
authors: Department of Pathology, AMRI Hospitals, Kolkata, West Bengal, India.
authors: Sanghamitra
authors: S
authors: Mukherjee
authors: Department of Pathology, AMRI Hospitals, Kolkata, West Bengal, India.
authors: Hema
authors: H
authors: Chakraborty
mesh_terms: D014408:Biomarkers, Tumor / Q000032:analysis; D002648:Child; D003248:Constipation / Q000209:etiology; D004067:Digestive System Neoplasms / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology*; D005729:Ganglioneuroma / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology*; D006651:Histocytochemistry; D006801:Humans; D007078:Ileal Neoplasms / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology*; D007150:Immunohistochemistry; D007415:Intestinal Obstruction / Q000209:etiology / Q000473:pathology; D008297:Male; D008853:Microscopy; D018814:Multiple Endocrine Neoplasia Type 2b / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology*; D011860:Radiography, Abdominal; D009418:S100 Proteins / Q000032:analysis; D014057:Tomography, X-Ray Computed
chemical_list: D014408:Biomarkers, Tumor; D009418:S100 Proteins