title: Curcumin cross-linked collagen aerogels with controlled anti-proteolytic and pro-angiogenic efficacy.
abstract: This paper elucidates the development of a curcumin cross-linked collagen aerogel system with controlled anti-proteolytic activity and pro-angiogenic efficacy. The results of this study showed that in situ cross-linking of curcumin with collagen leads to the development of aerogels with enhanced physical and mechanical properties. The integrity of collagen after cross-linking with curcumin was studied via FTIR spectroscopy. The results confirmed that the cross-linking with curcumin did not induce any structural changes in the collagen. The curcumin cross-linked collagen aerogels exhibited potent anti-proteolytic and anti-microbial activity. Scanning electron and atomic force microscopic analysis of curcumin cross-linked collagen aerogels showed a 3D microstructure that enhanced the adhesion and proliferation of cells. The highly organized geometry of collagen-curcumin aerogels enhanced the permeability and water-retaining ability required for the diffusion of nutrients that aid cellular growth. The pro-angiogenic properties of collagen-curcumin aerogels were ascribed to the cumulative effect of the nutraceutical and the collagen molecule, which augmented the restoration of damaged tissue. Further, these aerogels exhibited controlled anti-proteolytic activity, which makes them suitable 3D scaffolds for biomedical applications. This study provides scope for the development of biocompatible and bioresorbable collagen aerogel systems that use a nutraceutical as a cross-linker for biomedical applications.
authors: Biological Materials Laboratory, CSIR-Central Leather Research Institute, Adyar, Chennai 600020, Tamil Nadu, India.
authors: G
authors: G
authors: Dharunya
authors: N
authors: N
authors: Duraipandy
authors: Rachita
authors: R
authors: Lakra
authors: Purna Sai
authors: PS
authors: Korapatti
authors: R
authors: R
authors: Jayavel
authors: Manikantan Syamala
authors: MS
authors: Kiran
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry; D001672:Biocompatible Materials / Q000737:chemistry*; D002642:Chick Embryo; D049033:Chorioallantoic Membrane; D003094:Collagen / Q000737:chemistry*; D003432:Cross-Linking Reagents / Q000737:chemistry; D003474:Curcumin / Q000737:chemistry*; D019587:Dietary Supplements; D005260:Female; D006461:Hemolysis; D006801:Humans; D020100:Hydrogels / Q000737:chemistry; D007700:Kinetics; D008422:Materials Testing; D018919:Neovascularization, Physiologic; D010539:Permeability; D016062:Porosity; D051381:Rats; D017208:Rats, Wistar; D012212:Rheology; D013314:Stress, Mechanical; D013718:Tensile Strength; D054457:Tissue Scaffolds / Q000737:chemistry*; D014945:Wound Healing
chemical_list: D000900:Anti-Bacterial Agents; D001672:Biocompatible Materials; D003432:Cross-Linking Reagents; D020100:Hydrogels; D003094:Collagen; D003474:Curcumin