title: Comparison of therapeutic effects of topical azithromycin solution and systemic doxycycline on posterior blepharitis.
abstract: OBJECTIVE
  To compare the effect of azithromycin drop and doxycycline capsule on treatment of posterior blepharitis.
  
  
  METHODS
  Fifty patients (100 eyes) with moderate posterior blepharitis, randomly divided into two therapeutic groups; all the patients got warm eyelid compress and massage three times a day for 3wk. In addition the first group got azithromycin 1% drop, twice daily for 1wk and then one drop daily for 2wk. The second group got oral doxycycline 100 mg daily for 3wk. At the end of the research, patients' signs and symptoms were compared together. ANOVA, Chi-square and Mann-Whitney tests were used for statistical analysis.
  
  
  RESULTS
  Topical therapy with azithromycin and oral therapy with doxycycline relieved signs and symptoms after 3wk. There were no significant differences between symptoms healing rate and foreign body sensation healing in these two groups (P>0.05). However, azithromycin drop was more effective in reduction of eye redness and doxycycline was more effective in meibomian glands plugging healing and reducing the corneal staining.
  
  
  CONCLUSIONS
  Topical azithromycin could have similar effects as oral doxycycline on posterior blepharitis in improving subjective symptoms. However, doxycycline can reduce objective signs such as ocular surface staining and meibomian gland plugging more than azithromycin.
authors: Department of Ophthalmology, Faculty of Medicine, Hamadan University of Medical sciences, Hamadan 6516836595, Iran.
authors: Mehdi
authors: M
authors: Zandian
authors: Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran 193954763, Iran.
authors: Neda
authors: N
authors: Rahimian
authors: Department of Orthodontics, Faculty of Dentistry, Hamadan University of Medical Sciences, Hamadan 6516836595, Iran.
authors: Sanaz
authors: S
authors: Soheilifar
keywords: azithromycin; blepharitis; doxycycline