title: Affective Prosody and Depression After Stroke: A Pilot Study.
abstract: Poststroke depression (PSD) is a frequent complication of stroke with detrimental consequences in terms of quality of life and functional outcomes. In individuals with major depression, several studies have demonstrated an alteration of affective prosody. The aim of this study is to identify prosodic markers that may be predictive of PSD.
  
  
  
  Patient voices were recorded at baseline and 3 months after stroke. We extracted prosodic parameters, including fundamental frequency, percentage of voice breaks, and shimmer. Depression and anxiety symptoms were assessed 3 months later.
  
  
  
  Among the 49 patients included in the study, 22.5% developed PSD 3 months after stroke. A significant decrease was observed concerning the fundamental frequency among patients who developed PSD. Discriminant analysis demonstrated that initial voice breaks coupled with shimmer are strongly predictive of subsequent PSD.
  
  
  
  Early alterations of affective prosody are associated with a higher risk of PSD 3 months after a stroke. This new physiological approach overcomes traditional barriers associated with clinical instruments and contributes to the prediction of this disorder.
authors: From the Université de Bordeaux, INCIA, CNRS UMR5287, Talence, France (M.V., C.C., J.S., I.S., W.M.); Ecole Pratique des Hautes Etudes, Paris, France (M.V., C.C., J.S.); CHU Bordeaux, Pôle de Neurosciences Cliniques, Hôpital Pellegrin, Bordeaux, France (B.G., I.S.); and CESP, Université Paris Sud, Institut Mutualiste Montsouris, Paris, France (S.B.).
authors: Marie
authors: M
authors: Villain
authors: From the Université de Bordeaux, INCIA, CNRS UMR5287, Talence, France (M.V., C.C., J.S., I.S., W.M.); Ecole Pratique des Hautes Etudes, Paris, France (M.V., C.C., J.S.); CHU Bordeaux, Pôle de Neurosciences Cliniques, Hôpital Pellegrin, Bordeaux, France (B.G., I.S.); and CESP, Université Paris Sud, Institut Mutualiste Montsouris, Paris, France (S.B.). charlotte.cosin@ephe.sorbonne.fr.
authors: Charlotte
authors: C
authors: Cosin
authors: From the Université de Bordeaux, INCIA, CNRS UMR5287, Talence, France (M.V., C.C., J.S., I.S., W.M.); Ecole Pratique des Hautes Etudes, Paris, France (M.V., C.C., J.S.); CHU Bordeaux, Pôle de Neurosciences Cliniques, Hôpital Pellegrin, Bordeaux, France (B.G., I.S.); and CESP, Université Paris Sud, Institut Mutualiste Montsouris, Paris, France (S.B.).
authors: Bertrand
authors: B
authors: Glize
authors: From the Université de Bordeaux, INCIA, CNRS UMR5287, Talence, France (M.V., C.C., J.S., I.S., W.M.); Ecole Pratique des Hautes Etudes, Paris, France (M.V., C.C., J.S.); CHU Bordeaux, Pôle de Neurosciences Cliniques, Hôpital Pellegrin, Bordeaux, France (B.G., I.S.); and CESP, Université Paris Sud, Institut Mutualiste Montsouris, Paris, France (S.B.).
authors: Sylvie
authors: S
authors: Berthoz
authors: From the Université de Bordeaux, INCIA, CNRS UMR5287, Talence, France (M.V., C.C., J.S., I.S., W.M.); Ecole Pratique des Hautes Etudes, Paris, France (M.V., C.C., J.S.); CHU Bordeaux, Pôle de Neurosciences Cliniques, Hôpital Pellegrin, Bordeaux, France (B.G., I.S.); and CESP, Université Paris Sud, Institut Mutualiste Montsouris, Paris, France (S.B.).
authors: Joel
authors: J
authors: Swendsen
authors: From the Université de Bordeaux, INCIA, CNRS UMR5287, Talence, France (M.V., C.C., J.S., I.S., W.M.); Ecole Pratique des Hautes Etudes, Paris, France (M.V., C.C., J.S.); CHU Bordeaux, Pôle de Neurosciences Cliniques, Hôpital Pellegrin, Bordeaux, France (B.G., I.S.); and CESP, Université Paris Sud, Institut Mutualiste Montsouris, Paris, France (S.B.).
authors: Igor
authors: I
authors: Sibon
authors: From the Université de Bordeaux, INCIA, CNRS UMR5287, Talence, France (M.V., C.C., J.S., I.S., W.M.); Ecole Pratique des Hautes Etudes, Paris, France (M.V., C.C., J.S.); CHU Bordeaux, Pôle de Neurosciences Cliniques, Hôpital Pellegrin, Bordeaux, France (B.G., I.S.); and CESP, Université Paris Sud, Institut Mutualiste Montsouris, Paris, France (S.B.).
authors: Willy
authors: W
authors: Mayo
mesh_terms: D000328:Adult; D000368:Aged; D015415:Biomarkers; D003863:Depression / Q000175:diagnosis* / Q000209:etiology / Q000503:physiopathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010700:Phonetics; D010865:Pilot Projects; D012307:Risk Factors; D020521:Stroke / Q000150:complications* / Q000503:physiopathology / Q000523:psychology; D014705:Verbal Behavior / Q000502:physiology*
chemical_list: D015415:Biomarkers
keywords: anxiety; depression; discriminant analysis; quality of life; stroke