title: Retrospective Audit: Does Prior Assessment by Oral and Maxillofacial Surgeons Reduce the Risk of Osteonecrosis of The Jaw in Patients Receiving Bone-Targeted Therapies for Metastatic Cancers to the Skeleton?--Part II.
abstract: Men who receive bone-targeted therapy for metastatic prostate cancer are at increased risk of osteonecrosis of the jaw (ONJ). Development of ONJ has been associated with the administration of bone-targeted therapies in association with other risk factors. ONJ can be distressing for a patient because it can cause pain, risk of jaw fracture, body image disturbance, difficultly eating, and difficulty maintaining good oral hygiene. The aim of this article is to report results of an audit of prior assessment by oral and maxillofacial surgeons (OMFS) before initiation of bone-targeted therapies and whether it may reduce the risk of ONJ in patients receiving bone-targeted therapies for advanced cancers.
authors: Bruce
authors: B
authors: Turner
authors: Sacha
authors: S
authors: Ali
authors: Jhumur
authors: J
authors: Pati
authors: Vinod
authors: V
authors: Nargund
authors: Enamul
authors: E
authors: Ali
authors: Leo
authors: L
authors: Cheng
authors: Paula
authors: P
authors: Wells
mesh_terms: D059266:Bisphosphonate-Associated Osteonecrosis of the Jaw / Q000453:epidemiology* / Q000209:etiology; D050071:Bone Density Conservation Agents / Q000009:adverse effects*; D001859:Bone Neoplasms / Q000188:drug therapy* / Q000556:secondary; D001943:Breast Neoplasms / Q000473:pathology*; D054869:Clinical Audit; D000069448:Denosumab / Q000009:adverse effects; D004164:Diphosphonates / Q000009:adverse effects; D005260:Female; D006801:Humans; D007093:Imidazoles / Q000009:adverse effects; D007571:Jaw Diseases / Q000139:chemically induced / Q000453:epidemiology; D008175:Lung Neoplasms / Q000473:pathology; D008297:Male; D010020:Osteonecrosis / Q000139:chemically induced / Q000453:epidemiology; D057184:Practice Patterns, Nurses'; D011471:Prostatic Neoplasms / Q000473:pathology*; D012004:Rectal Neoplasms / Q000473:pathology; D012017:Referral and Consultation; D012189:Retrospective Studies; D018570:Risk Assessment; D009057:Stomatognathic Diseases / Q000175:diagnosis* / Q000628:therapy; D013515:Surgery, Oral; D014081:Tooth Extraction; D000077211:Zoledronic Acid
chemical_list: D050071:Bone Density Conservation Agents; D004164:Diphosphonates; D007093:Imidazoles; D000069448:Denosumab; D000077211:Zoledronic Acid