title: Comparison of glomerular filtration rate measurements with the two-plasma sample technique using Tc-99m DTPA and other methods in donor candidates for renal transplantation.
abstract: OBJECTIVE
  Accurate measurement of glomerular filtration rate (GFR) in the evaluation of renal functions in potential kidney donors is associated with important outcomes for both the donor and recipient. We intended to determine the efficacy of various methods while estimating GFR in potential living kidney donors.
  
  
  METHODS
  Fifty-three potential kidney donors (31 females, 22 males; mean age: 50.1 years) were included in this study. GFR was estimated simultaneously using the following methods: Gates' method, Cockcroft-Gault (CG) and modification of diet in renal disease (MDRD) prediction equations, and the two-plasma sample (TPS) technique. Using TPS as the reference method, the estimations of GFR with the other methods were compared with that of TPS.
  
  
  RESULTS
  The mean ± SD GFR was 86.43 ± 11.37 mL min-1 1.73 m-2 with TPS. GFR values calculated using Gates' method and MDRD 1, MDRD 2, reexpressed MDRD, and CG prediction equations were 105.25 ± 16.12 mL min-1 1.73 m-2, 114.63 ± 32.51 mL min-1 1.73 m-2, 113.2 ± 35.23 mL min-1 1.73 m-2, 104.23 ± 23.12 mL min-1 1.73 m-2, and 99.35 ± 20.01 mL min-1 1.73 m-2, respectively. While there was a strong statistically significant correlation between the TPS and Gates' methods, moderate correlation was found between TPS and the MDRD 1, MDRD 2, and reexpressed MDRD prediction equations.
  
  
  CONCLUSIONS
  Our results indicated that the performance of Gates' method in total GFR estimation was better than the prediction equations in potential kidney donors.
authors: Department of Nuclear Medicine, Faculty of Medicine, Atatürk University, Erzurum, Turkey.
authors: Arif Kürşad
authors: AK
authors: Ayan
authors: Department of Nuclear Medicine, Faculty of Medicine, İstanbul Medeniyet University, İstanbul, Turkey.
authors: Erhan
authors: E
authors: Varoğlu
authors: Department of Internal Medicine, Faculty of Medicine, Atatürk University, Erzurum, Turkey.
authors: Mustafa
authors: M
authors: Keleş
authors: Department of Nuclear Medicine, Faculty of Medicine, Atatürk University, Erzurum, Turkey.
authors: Bedri
authors: B
authors: Seven
authors: Department of Internal Medicine, Faculty of Medicine, Atatürk University, Erzurum, Turkey.
authors: Abdullah
authors: A
authors: Uyanik
authors: Department of Nuclear Medicine, Faculty of Medicine, Atatürk University, Erzurum, Turkey.
authors: Ebru
authors: E
authors: Örsal
mesh_terms: D003404:Creatinine; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D016030:Kidney Transplantation; D019520:Living Donors; D008297:Male; D008875:Middle Aged; D016284:Technetium Tc 99m Pentetate
chemical_list: D003404:Creatinine; D016284:Technetium Tc 99m Pentetate
keywords: Glomerular filtration rate; kidney donors; two-plasma sample