title: Bidirectional variability in motor cortex excitability modulation following 1 mA transcranial direct current stimulation in healthy participants.
abstract: Due to the high interindividual response variability following transcranial direct current stimulation (tDCS), it is apparent that further research of the long-lasting effects of the stimulation technique is required. We aimed to investigate interindividual variability following anodal tDCS and cathodal tDCS in a large-scale prospective cross-over study. Motor cortex physiology measurements were obtained using transcranial magnetic stimulation (TMS) in 59 healthy participants comparing motor-evoked potential (MEP) magnitudes following two tDCS paradigms: 1 mA anodal tDCS for 13 min and 1 mA cathodal tDCS for 9 min. Analysis compared MEP changes over time for both polarities. Additionally, we applied hierarchical cluster analysis to assess the dynamics of poststimulation changes. Overall, anodal tDCS resulted in a significant increase in corticospinal excitability lasting for 40 min poststimulation, whereas cathodal tDCS did not alter corticospinal excitability. Cluster analysis revealed for cathodal tDCS both a cluster showing significant stable MEP reduction and a second cluster displaying MEP increase over time. Two diametrical clusters were also found for anodal tDCS Regardless of polarity, individuals with MEP increase following stimulation showed steeper cortical recruitment curves compared to the clusters with decreased MEP magnitudes. The observed findings confirm a bidirectional modulation of corticospinal excitability following 1 mA tDCS in separate subgroups and the relationship to cortical recruitment.
authors: Department of Psychiatry and Psychotherapy, Ludwig Maximillian University, Munich, Germany.
authors: Wolfgang
authors: W
authors: Strube
authors: Department of Psychiatry and Psychotherapy, Ludwig Maximillian University, Munich, Germany.
authors: Tilmann
authors: T
authors: Bunse
authors: Department of Neurology, University Medical Hospital Bergmannsheil, Bochum, Germany Leibniz Research Centre for Working Environment and Human Factors TU Dortmund, Dortmund, Germany.
authors: Michael A
authors: MA
authors: Nitsche
authors: Department of Psychiatry and Psychotherapy, Ludwig Maximillian University, Munich, Germany.
authors: Alexandra
authors: A
authors: Nikolaeva
authors: Department of Psychiatry and Psychotherapy, Ludwig Maximillian University, Munich, Germany.
authors: Ulrich
authors: U
authors: Palm
authors: Department of Psychiatry and Psychotherapy, Ludwig Maximillian University, Munich, Germany.
authors: Frank
authors: F
authors: Padberg
authors: Department of Psychiatry and Psychotherapy, Ludwig Maximillian University, Munich, Germany.
authors: Peter
authors: P
authors: Falkai
authors: Department of Psychiatry and Psychotherapy, Ludwig Maximillian University, Munich, Germany alkomiet.hasan@med.uni-muenchen.de.
authors: Alkomiet
authors: A
authors: Hasan
mesh_terms: D000328:Adult; D016000:Cluster Analysis; D000071080:Cortical Excitability; D019054:Evoked Potentials, Motor; D005260:Female; D006801:Humans; D008297:Male; D009044:Motor Cortex / Q000502:physiology*; D065908:Transcranial Direct Current Stimulation / Q000379:methods*; D055815:Young Adult
keywords: Motor‐cortical plasticity; response variability; transcranial direct current stimulation