title: Cutaneous peripheral T-cell lymphoma, not otherwise specified: A single-center prognostic analysis.
abstract: BACKGROUND
  Peripheral T-cell lymphoma, not otherwise specified (PTCL-NOS) is a rare and aggressive disease either originating in or secondarily involving the skin.
  
  
  OBJECTIVE
  We sought to assess clinical, histopathologic, and prognostic features of patients with cutaneous PTCL-NOS.
  
  
  METHODS
  This was a retrospective chart review of patients with cutaneous PTCL-NOS between 1993 and 2013.
  
  
  RESULTS
  Thirty patients with PTCL-NOS were included. Fourteen had skin-only disease and 15 had concurrent skin and systemic disease at presentation. In primary cutaneous PTCL-NOS, the overall survival rate at 5 years was 61% (95% confidence interval, 37-100%; number still at risk, 2). The median overall survival was 5.6 years. Patients were diagnosed a median of 2.4 months from symptom onset. Patients with concurrent disease died a median of 2.1 years after diagnosis. The estimated overall survival rate at 5 years after diagnosis was 29% (95% confidence interval, 13-67%; number at risk, 3). The median overall survival was 3.9 years. Patients were diagnosed a median of 6 months from symptom onset, with a 53% increased risk of death for each year from symptom onset to diagnosis.
  
  
  CONCLUSIONS
  This was a retrospective study with a limited number of cases.
  
  
  CONCLUSIONS
  Age at diagnosis and B-symptoms predict poor survival in patients with cutaneous PTCL-NOS. In addition, poorer survival is observed in patients with multifocal lesions and concomitant skin and systemic PTCL-NOS.
authors: Department of Dermatology, Mayo Clinic, Rochester, Minnesota.
authors: Stanislav N
authors: SN
authors: Tolkachjov
authors: Associated Skin Care Specialists PA, Fridley, Minnesota.
authors: Roger H
authors: RH
authors: Weenig
authors: Department of Dermatology, Mayo Clinic, Rochester, Minnesota; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota. Electronic address: comfere.nneka@mayo.edu.
authors: Nneka I
authors: NI
authors: Comfere
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D020405:Dermis / Q000473:pathology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D016130:Immunophenotyping; D016410:Lymphoma, T-Cell, Cutaneous / Q000401:mortality* / Q000473:pathology / Q000628:therapy; D016411:Lymphoma, T-Cell, Peripheral / Q000401:mortality* / Q000473:pathology / Q000628:therapy; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009928:Organ Specificity; D011379:Prognosis; D012189:Retrospective Studies; D012878:Skin Neoplasms / Q000401:mortality* / Q000473:pathology / Q000628:therapy; D040521:Subcutaneous Tissue / Q000473:pathology; D015996:Survival Rate; D016896:Treatment Outcome
keywords: PTCL-NOS; PTCLU; cutaneous; extranodal; lymphoma; peripheral T-cell