title: Effect of surface coating of KYb2F7:Tm(3+) on optical properties and biomedical applications.
abstract: This project aims to provide an insight on the effects of biocompatible polymers on the optical properties and the nanoparticle-cell interaction of KYb2F7:Tm(3+) nanocrystals that exhibit strong near infrared (NIR) fluorescence. KYb2F7:Tm(3+) nanocrystals were synthesized with a diameter of 20-30 nm and surface modified with poly(ethylene glycol), Pluronic(®) F-127, and poly(N-vinylpyrrolidone), due to the associated advantages. Some of these include biocompatibility and biodistribution in the instance of agglomeration and hydrophobicity as well as the addition of a targeting agent and drug loading by further functionalization. Despite the decrease in fluorescence intensity induced by the surface modification, thulium's emission fingerprint was easily detected. Moreover, surface modified KYb2F7:Tm(3+) nanocrystals failed to induce a toxic response on endothelial cells following a 24 h uptake period up to concentrations of 100 μg ml(-1). In vitro toxicity and confocal imaging have demonstrated the versatility of these NIR fluorescence nanocrystals in biomedical imaging, drug delivery, and photodynamic therapy.
authors: Physics and Astronomy Department, University of Texas at San Antonio, TX, USA.
authors: Francisco J
authors: FJ
authors: Pedraza
authors: Julio C
authors: JC
authors: Avalos
authors: Brian G
authors: BG
authors: Yust
authors: Andrew
authors: A
authors: Tsin
authors: Dhiraj K
authors: DK
authors: Sardar
mesh_terms: D016503:Drug Delivery Systems; D053758:Nanoparticles; D011092:Polyethylene Glycols; D013499:Surface Properties; D013932:Thulium; D014018:Tissue Distribution
chemical_list: D011092:Polyethylene Glycols; D013932:Thulium