title: Altered plasma levels of chemokines in autism and their association with social behaviors.
abstract: Autism Spectrum Disorder (ASD) is a group of neurodevelopment disorders with an unclear etiology. Chemokines have been implicated in the etiology and pathogenesis of ASD. The current study investigated the plasma levels of seven chemokines (RANTES, Eotaxin, MIP-1 α, MIP-1 β, MCP-1, IP-10, and MIG) in 42 young autistic patients and 35 age-matched typically developing (TD) children. The study also tested the association between these chemokine levels and social behaviors, as measured by the Social Responsiveness Scale (SRS). Compared to the TD children, RANTES, MIP-1α, and MIP-1β were higher, while IP-10 and MIG were lower in the autistic patients, after correcting for multiple comparisons. Among these seven chemokines, MIP-1α, MIP-1β and IP-10 levels were found to be associated with social behaviors in all the participants. Moreover, MIP-1α and IP-10 were found to be independent predictors of social behaviors. The results of our study support the hypothesis that altered chemokine levels are involved in the pathophysiology of ASD and they indicate that chemokines plasma levels could be potential biomarkers for ASD.
authors: The National Clinical Research Center for Mental Health Disorders, China; The National Technology Institute of Psychiatry, China; Key Laboratory of Psychiatry and Mental Health of Hunan Province, Changsha, China; Institute of Mental Health, the Second Xiangya Hospital, Central South University, China.
authors: Yidong
authors: Y
authors: Shen
authors: The National Clinical Research Center for Mental Health Disorders, China; The National Technology Institute of Psychiatry, China; Key Laboratory of Psychiatry and Mental Health of Hunan Province, Changsha, China; Institute of Mental Health, the Second Xiangya Hospital, Central South University, China.
authors: JInajun
authors: J
authors: Ou
authors: The National Clinical Research Center for Mental Health Disorders, China; The National Technology Institute of Psychiatry, China; Key Laboratory of Psychiatry and Mental Health of Hunan Province, Changsha, China; Institute of Mental Health, the Second Xiangya Hospital, Central South University, China.
authors: Mengmeng
authors: M
authors: Liu
authors: The National Clinical Research Center for Mental Health Disorders, China; The National Technology Institute of Psychiatry, China; Key Laboratory of Psychiatry and Mental Health of Hunan Province, Changsha, China; Institute of Mental Health, the Second Xiangya Hospital, Central South University, China; Neuropsychology and Applied Cognitive Neuroscience Research Group, Institute of Psychology, Chinese Academy of Sciences, Beijing, China.
authors: Lijuan
authors: L
authors: Shi
authors: The National Clinical Research Center for Mental Health Disorders, China; The National Technology Institute of Psychiatry, China; Key Laboratory of Psychiatry and Mental Health of Hunan Province, Changsha, China; Institute of Mental Health, the Second Xiangya Hospital, Central South University, China.
authors: Yamin
authors: Y
authors: Li
authors: The National Clinical Research Center for Mental Health Disorders, China; The National Technology Institute of Psychiatry, China; Key Laboratory of Psychiatry and Mental Health of Hunan Province, Changsha, China; Institute of Mental Health, the Second Xiangya Hospital, Central South University, China.
authors: Lu
authors: L
authors: Xiao
authors: The National Clinical Research Center for Mental Health Disorders, China; The National Technology Institute of Psychiatry, China; Key Laboratory of Psychiatry and Mental Health of Hunan Province, Changsha, China; Institute of Mental Health, the Second Xiangya Hospital, Central South University, China.
authors: Huixi
authors: H
authors: Dong
authors: The National Clinical Research Center for Mental Health Disorders, China; The National Technology Institute of Psychiatry, China; Key Laboratory of Psychiatry and Mental Health of Hunan Province, Changsha, China; Institute of Mental Health, the Second Xiangya Hospital, Central South University, China; Lieber Institute for Brain Development, Johns Hopkins University Medical Campus, Baltimore, MD, USA.
authors: Fengyu
authors: F
authors: Zhang
authors: State Key Laboratory of Medical Genetics, Central South University, Changsha, China.
authors: Kun
authors: K
authors: Xia
authors: The National Clinical Research Center for Mental Health Disorders, China; The National Technology Institute of Psychiatry, China; Key Laboratory of Psychiatry and Mental Health of Hunan Province, Changsha, China; Institute of Mental Health, the Second Xiangya Hospital, Central South University, China; State Key Laboratory of Medical Genetics, Central South University, Changsha, China. Electronic address: zhaojingpingcsu@163.com.
authors: Jingping
authors: J
authors: Zhao
mesh_terms: D000067877:Autism Spectrum Disorder / Q000276:immunology / Q000523:psychology; D001321:Autistic Disorder / Q000276:immunology* / Q000523:psychology; D001364:Awareness; D016022:Case-Control Studies; D054413:Chemokine CCL11 / Q000276:immunology; D018932:Chemokine CCL2 / Q000276:immunology; D054405:Chemokine CCL3 / Q000276:immunology; D054407:Chemokine CCL4 / Q000276:immunology; D018946:Chemokine CCL5 / Q000276:immunology; D054357:Chemokine CXCL10 / Q000276:immunology; D054370:Chemokine CXCL9 / Q000276:immunology; D002648:Child; D002675:Child, Preschool; D003142:Communication; D005260:Female; D006801:Humans; D008297:Male; D009042:Motivation; D012919:Social Behavior; D012938:Social Perception
chemical_list: C515456:CCL11 protein, human; C111835:CCL2 protein, human; C515429:CCL3 protein, human; C066507:CCL4 protein, human; C483024:CCL5 protein, human; C114753:CXCL10 protein, human; C080810:CXCL9 protein, human; D054413:Chemokine CCL11; D018932:Chemokine CCL2; D054405:Chemokine CCL3; D054407:Chemokine CCL4; D018946:Chemokine CCL5; D054357:Chemokine CXCL10; D054370:Chemokine CXCL9
keywords: Autism; Biomarker; Chemokines; Social behavior