title: CD10 down expression in follicular lymphoma correlates with gastrointestinal lesion involving the stomach and large intestine.
abstract: Follicular lymphoma (FL) shows co-expression of B-cell lymphoma 2 (BCL2) and CD10, whereas downexpression of CD10 is occasionally experienced in gastrointestinal (GI) FL with unknown significance. Gastrointestinal FL is a rare variant of FL, and its similarity with mucosa-associated lymphoid tissue lymphoma was reported. We investigated the clinicopathological and genetic features of CD10 downexpressed (CD10down) GI-FL. The diagnosis of CD10downFL was carried out with a combination of pathological and molecular analyses. The incidence of CD10downGI-FL was shown in 35/172 (20.3%) cases, which was more frequent than nodal FL (3.5%, P < 0.001). The difference was additionally significant between GI-FL and nodal FL when the analysis was confined to primary GI-FL (55.2% vs 3.5%, P < 0.001). Compared to CD10+GI-FL, CD10downGI-FL significantly involved the stomach or large intestine (P = 0.015), and additionally showed the downexpression of BCL6 (P < 0.001). The follicular dendritic cell meshwork often showed a duodenal pattern in the CD10downgroup (P = 0.12). Furthermore, a lymphoepithelial lesion was observed in 5/12 (40%) gastric FL cases, which indicated caution in the differentiation of mucosa-associated lymphoid tissue lymphoma. Molecular analyses were undertaken in seven cases of CD10downGI-FL, and an identical clone was found between CD10downfollicles and CD10+BCL2+neoplastic follicles. In the diagnosis of cases with CD10downBCL2+follicles, careful examination with molecular studies should be carried out.
authors: Department of Pathology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.
authors: Nobuhiko
authors: N
authors: Ohnishi
authors: Department of Pathology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.
authors: Katsuyoshi
authors: K
authors: Takata
authors: Department of Pathology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.
authors: Tomoko
authors: T
authors: Miyata-Takata
authors: Department of Pathology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.
authors: Yasuharu
authors: Y
authors: Sato
authors: Division of Gastroenterology, Department of Internal Medicine, Hiroshima Red Cross Hospital and Atomic-Bomb Survivors Hospital, Hiroshima, Japan.
authors: Akira
authors: A
authors: Tari
authors: Department of Pathology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.
authors: Yuka
authors: Y
authors: Gion
authors: Department of Pathology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.
authors: Mai
authors: M
authors: Noujima-Harada
authors: Department of Pathology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.
authors: Kohei
authors: K
authors: Taniguchi
authors: Department of Pathology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.
authors: Tetsuya
authors: T
authors: Tabata
authors: Department of Pathology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.
authors: Keina
authors: K
authors: Nagakita
authors: Department of Pathology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.
authors: Shizuma
authors: S
authors: Omote
authors: Department of Pathology, National Hospital Organization Shikoku Cancer Center, Matsuyama, Japan.
authors: Hiroyuki
authors: H
authors: Takahata
authors: Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.
authors: Masaya
authors: M
authors: Iwamuro
authors: Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.
authors: Hiroyuki
authors: H
authors: Okada
authors: Department of Hematology and Oncology, Okayama University Hospital, Okayama, Japan.
authors: Yoshinobu
authors: Y
authors: Maeda
authors: Department of Pathology, Okayama University Hospital, Okayama, Japan.
authors: Hiroyuki
authors: H
authors: Yanai
authors: Department of Pathology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.
authors: Tadashi
authors: T
authors: Yoshino
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000465:Algorithms; D015536:Down-Regulation; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D007150:Immunohistochemistry; D017404:In Situ Hybridization, Fluorescence; D007420:Intestine, Large / Q000201:enzymology / Q000473:pathology*; D008224:Lymphoma, Follicular / Q000175:diagnosis / Q000201:enzymology* / Q000235:genetics / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D015260:Neprilysin / Q000096:biosynthesis / Q000235:genetics / Q000378:metabolism*; D016133:Polymerase Chain Reaction; D013270:Stomach / Q000201:enzymology / Q000473:pathology*
chemical_list: D015260:Neprilysin
keywords: CD10; downexpression; follicular lymphoma; gastrointestinal tract; involvement of stomach and large intestine