title: Evaluation of the relationship between migraine disorder andoral comorbidities: multicenter randomized clinical trial.
abstract: OBJECTIVE
  Although migraine is a common disorder, there is a lack of research investigating the possible relationship between migraine and oral health. The aim of the present study was to explore the relationship between temporomandibular disorders, bruxism, dental caries, periodontal status, and migraine disorder in a multicenter, parallel, case-controlled clinical study.
  
  
  METHODS
  A total of 2001 participants were divided into two groups: migraineurs (nm = 998) and nonmigraineurs (nh = 1003). International Headache Society's Second Edition of International Classification of Headache Disorders and modified Migraine Disability Assessment surveys were administered to evaluate the level of migraine; a pretreatment questionnaire and the World Health Organization oral health assessment form were used to determine the oral comorbidities and their possible effects on DMFT index, gingival plaque index, existence of temporomandibular disorders, bruxism, and consistency of daily oral hygiene habits.
  
  
  RESULTS
  The mean age was 39.6 ± 10.5 years. Female patients seemed to experience migraine attacks more than male patients (64%). The frequency of gastroesophageal reflux was higher in migraineurs in comparison with nonmigraineurs (47%) and tooth wear and abrasion also seemed more frequent (76%). DMFT and plaque index scores showed significant differences for both groups.
  
  
  CONCLUSIONS
  There is a strong relationship between migraine and oral health status. The existence of reflux in addition to migraine leads to higher dental problems.
authors: Department of Restorative Dentistry, Faculty of Dentistry, Ege University, İzmir, Turkey.
authors: Cem
authors: C
authors: Peşkersoy
authors: Department of Neurology, Faculty of Medicine, İzmir Katip Çelebi University, İzmir, Turkey.
authors: Şule
authors: Ş
authors: Peker
authors: Department of Restorative Dentistry, Faculty of Dentistry, Ege University, İzmir, Turkey.
authors: Ayşegül
authors: A
authors: Kaya
authors: Department of Pediatric Neurology, İzmir Behçet Uz Pediatric Diseases and Surgery Training and Research Hospital, İzmir, Turkey.
authors: Aycan
authors: A
authors: Ünalp
authors: Department of Restorative Dentistry, Faculty of Dentistry, Gazi University, Ankara, Turkey.
authors: Necmi
authors: N
authors: Gökay
mesh_terms: D000328:Adult; D015897:Comorbidity; D003731:Dental Caries; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008881:Migraine Disorders; D009910:Oral Hygiene; D010512:Periodontal Index
keywords: Migraine; dental caries; gastroesophageal reflux disease; gingival plaque index; oral health