title: Serum resistin is inversely related to breast cancer risk in premenopausal women.
abstract: BACKGROUND
  Adipokines have been suggested as potential mediators linking obesity and breast cancer. Resistin is the least-studied adipokine with diverse findings regarding its association with disease development and progression. The present study aimed to determine resistin serum levels in breast cancer in relation to the histological type of disease and to investigate their association with breast cancer risk.
  
  
  METHODS
  The study included 216 women, of which 163 were diagnosed with breast cancer (58 with IDC, 52 with DCIS and 53 with LN) and 53 were healthy. Serum levels of resistin, leptin and adiponectin were quantitatively determined in duplicates by ELISA. Differences in resistin levels among patient groups were evaluated with Kruskal-Wallis and Mann-Whitney tests. The association of resistin with breast cancer risk was evaluated by multiple logistic regression analysis.
  
  
  RESULTS
  Resistin levels varied between histological types of breast cancer (p = 0.044). Significant differences in serum resistin were observed in IDC patients compared to those with DCIS and to controls (p < 0.014 and p < 0.03, respectively). Decreased levels of resistin, adiponectin and leptin were observed in premenopausal patients. Resistin was associated with a reduced risk for ductal carcinoma only in premenopausal women (OR: 0.364, 95% CI: 0.154-0.862, p < 0.022).
  
  
  CONCLUSIONS
  Our findings indicate that resistin levels were inversely related to breast cancer risk in premenopausal women, supporting a protective role of resistin for these patients. Further advances in adipokine research may lead to tangible benefits for overweight/obese women at an increased risk for breast cancer.
authors: 1st Department of Propaedeutic Surgery, Hippokratio Hospital, School of Medicine, University of Athens, Athens, Greece.
authors: Georgia P
authors: GP
authors: Georgiou
authors: Research Center, Hellenic Anticancer Institute, Athens, Greece.
authors: Xeni
authors: X
authors: Provatopoulou
authors: Research Center, Hellenic Anticancer Institute, Athens, Greece.
authors: Eleni
authors: E
authors: Kalogera
authors: Department of Biological Chemistry, School of Medicine, University of Athens, Athens, Greece; 1st Department of Cardiology, School of Medicine, University of Athens, Athens, Greece.
authors: Gerasimos
authors: G
authors: Siasos
authors: 1st Department of Propaedeutic Surgery, Hippokratio Hospital, School of Medicine, University of Athens, Athens, Greece.
authors: Evangelos
authors: E
authors: Menenakos
authors: 1st Department of Propaedeutic Surgery, Hippokratio Hospital, School of Medicine, University of Athens, Athens, Greece.
authors: George C
authors: GC
authors: Zografos
authors: Research Center, Hellenic Anticancer Institute, Athens, Greece. Electronic address: antgouna@otenet.gr.
authors: Antonia
authors: A
authors: Gounaris
mesh_terms: D052242:Adiponectin / Q000097:blood; D000328:Adult; D014408:Biomarkers, Tumor / Q000097:blood; D001943:Breast Neoplasms / Q000097:blood / Q000209:etiology*; D016022:Case-Control Studies; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D020738:Leptin / Q000097:blood; D016015:Logistic Models; D008875:Middle Aged; D017697:Premenopause / Q000097:blood*; D052243:Resistin / Q000097:blood*; D012307:Risk Factors; D018709:Statistics, Nonparametric
chemical_list: C499918:ADIPOQ protein, human; D052242:Adiponectin; D014408:Biomarkers, Tumor; D020738:Leptin; C499624:RETN protein, human; D052243:Resistin
keywords: Adipokines; BC risk; Breast cancer; Obesity; Resistin; Serum levels