title: Changes of regulatory T cells, transforming growth factor-beta and interleukin-10 in patients with type 1 diabetes mellitus: A systematic review and meta-analysis.
abstract: Regulatory T lymphocyte cells (Treg) associated with interleukin-10 (IL-10) and transforming growth factor-β (TGF-β) have implicated in the development of type 1 diabetes mellitus (T1DM), yet the existing evidence remains unclear. Hereby we performed a systematic review and meta-analysis to characterize the changes in T1DM patients. A total of 1407 T1DM patients and 1373 healthy controls from 40 case-control studies were eventually included in the pooling analysis. Compared with the controls, T1DM patients had decreased frequency of CD4(+)CD25(+)Treg (p=0.0003), CD4(+)CD25(+)Foxp3(+)Treg (p=0.020), and the level of TGF-β (p=0.030). Decrease in IL-10 (p=0.14) was not significant. All the changes remained significant when the studies with low NOS scores and publication bias were excluded. In conclusion, peripheral Treg and serum TGF-β are reduced in type 1 diabetes mellitus whereas changes in serum IL-10 are not significant.
authors: Department of Immunology, Faculty of Basic Medicine, Guilin Medical University, Guilin 541004, China; Department of Immunology, School of Basic Medical Science, Central South University, Changsha, Hunan 410078, China.
authors: Yong-Chao
authors: YC
authors: Qiao
authors: Diabetic Systems Medicine, Guangxi Key Laboratory of Excellence, Guilin Medical University, Guilin 541004, China.
authors: Jian
authors: J
authors: Shen
authors: Diabetic Systems Medicine, Guangxi Key Laboratory of Excellence, Guilin Medical University, Guilin 541004, China.
authors: Xue-Zhi
authors: XZ
authors: Hong
authors: Department of Immunology, Faculty of Basic Medicine, Guilin Medical University, Guilin 541004, China; Diabetic Systems Medicine, Guangxi Key Laboratory of Excellence, Guilin Medical University, Guilin 541004, China.
authors: Ling
authors: L
authors: Liang
authors: Department of Immunology, Faculty of Basic Medicine, Guilin Medical University, Guilin 541004, China; Diabetic Systems Medicine, Guangxi Key Laboratory of Excellence, Guilin Medical University, Guilin 541004, China.
authors: Chao-Sheng
authors: CS
authors: Bo
authors: Diabetic Systems Medicine, Guangxi Key Laboratory of Excellence, Guilin Medical University, Guilin 541004, China.
authors: Yi
authors: Y
authors: Sui
authors: Department of Immunology, Faculty of Basic Medicine, Guilin Medical University, Guilin 541004, China; Diabetic Systems Medicine, Guangxi Key Laboratory of Excellence, Guilin Medical University, Guilin 541004, China; Department of Immunology, School of Basic Medical Science, Central South University, Changsha, Hunan 410078, China. Electronic address: zhaohailu9@126.com.
authors: Hai-Lu
authors: HL
authors: Zhao
mesh_terms: D016022:Case-Control Studies; D003922:Diabetes Mellitus, Type 1 / Q000097:blood / Q000276:immunology* / Q000378:metabolism; D005260:Female; D051858:Forkhead Transcription Factors / Q000097:blood / Q000276:immunology / Q000378:metabolism; D006801:Humans; D016753:Interleukin-10 / Q000097:blood / Q000276:immunology* / Q000378:metabolism; D053645:Interleukin-2 Receptor alpha Subunit / Q000097:blood / Q000276:immunology / Q000378:metabolism; D008297:Male; D050378:T-Lymphocytes, Regulatory / Q000276:immunology* / Q000378:metabolism; D016212:Transforming Growth Factor beta / Q000097:blood / Q000276:immunology* / Q000378:metabolism
chemical_list: C418974:FOXP3 protein, human; D051858:Forkhead Transcription Factors; D053645:Interleukin-2 Receptor alpha Subunit; D016212:Transforming Growth Factor beta; D016753:Interleukin-10
keywords: Interleukin-10; Meta-analysis; Regulatory T cells; Transforming growth factor-β; Type 1 diabetes mellitus