title: Early initiation of MARS® dialysis in Amanita phalloides-induced acute liver injury prevents liver transplantation.
abstract: Amanita phalloides is the most relevant mushroom intoxication leading to acute liver failure. The two principal groups of toxins, the amatoxins and the phallotoxins, are small oligopeptides highly resistant to chemical and physical influences. The amatoxins inhibit eukaryotic RNA polymerase II causing transcription arrest affecting mainly metabolically highly active cells like hepatocytes and renal cells. The clinically most characteristic symptom is a 6-40 h lag phase before onset of gastrointestinal symptoms and the rapid progression of acute liver failure leading to multi-organ failure and death within a week if left untreated. Extracorporeal albumin dialysis (ECAD) was reported to improve patient's outcome or facilitate bridging to transplantation. In our tertiary center, out of nine intoxicated individuals from five non-related families six patients presented with acute liver injury; all of them were treated with ECAD using the MARS® system. Four of them were listed on admission for high urgency liver transplantation. In addition to standard medical treatment for Amanita intoxication we initiated ECAD once patients were admitted to our center. Overall 16 dialysis sessions were performed. All patients survived with full native liver recovery without the need for transplantation. ECAD was well tolerated; no severe adverse events were reported during treatment. Coagulopathy resolved within days in all patients, and acute kidney injury in all but one individual. In conclusion, ECAD is highly effective in treating intoxication with Amanita phalloides. Based on these experiences we suggest early initiation and repeated sessions depending on response to ECAD with the chance of avoiding liver transplantation.
authors: Department for Transplant Medicine, University Hospital Münster, Münster, Germany.
authors: Mike Hendrik
authors: MH
authors: Pillukat
authors: Department for Transplant Medicine, University Hospital Münster, Münster, Germany.
authors: Tina
authors: T
authors: Schomacher
authors: Department for Transplant Medicine, University Hospital Münster, Münster, Germany.
authors: Peter
authors: P
authors: Baier
authors: Department for Internal Medicine D, General Internal Medicine and Nephrology, University Hospital Münster, Münster, Germany.
authors: Gert
authors: G
authors: Gabriëls
authors: Department for Internal Medicine D, General Internal Medicine and Nephrology, University Hospital Münster, Münster, Germany.
authors: Hermann
authors: H
authors: Pavenstädt
authors: Department for Transplant Medicine, University Hospital Münster, Münster, Germany.
authors: Hartmut H J
authors: HH
authors: Schmidt
mesh_terms: D058186:Acute Kidney Injury / Q000209:etiology / Q000628:therapy; D000328:Adult; D000368:Aged; D000545:Amanita; D056486:Chemical and Drug Induced Liver Injury / Q000097:blood / Q000175:diagnosis / Q000209:etiology / Q000628:therapy*; D003956:Dialysis / Q000295:instrumentation / Q000379:methods*; D005260:Female; D006801:Humans; D008111:Liver Function Tests; D008297:Male; D008567:Membranes, Artificial; D008875:Middle Aged; D009145:Mushroom Poisoning / Q000097:blood / Q000150:complications / Q000175:diagnosis / Q000628:therapy*; D011485:Protein Binding; D020127:Recovery of Function; D012709:Serum Albumin / Q000008:administration & dosage* / Q000378:metabolism; D000075462:Serum Albumin, Human; D016060:Sorption Detoxification / Q000295:instrumentation / Q000379:methods*; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: C422455:ALB protein, human; D008567:Membranes, Artificial; D012709:Serum Albumin; D000075462:Serum Albumin, Human