title: Comparison of brain activation patterns during executive function tasks in hoarding disorder and non-hoarding OCD.
abstract: We examined differences in regional brain activation during tests of executive function in individuals with Hoarding Disorder (HD), Obsessive Compulsive Disorder (OCD), and healthy controls (HC) using functional magnetic resonance imaging (fMRI). Participants completed computerized versions of the Stroop and Go/No-Go task. We found that during the conflict monitoring and response inhibition condition in the Go/No-Go task, individuals with HD had significantly greater activity than controls in the anterior cingulate cortex (ACC) and right dorsolateral prefrontal cortex (DLPFC). HD also exhibited significantly greater right DLPFC activity than OCD. We also observed significant differences in activity between HD and HC and between HD and OCD in regions (ACC, anterior insula, orbitofrontal cortex, and striatum) involved in evaluating stimulus-response-reward associations, or the personal and task-relevant value of stimuli and behavioral responses to stimuli. These results support the hypothesis that individuals with HD have difficulty deciding on the value or task relevance of stimuli, and may perceive an abnormally high risk of negative feedback for difficult or erroneous cognitive behavior.
authors: Department of Psychiatry, UCSF Weill Institute for Neurosciences, University of California, San Francisco, USA.
authors: Christina M
authors: CM
authors: Hough
authors: Department of Radiology and Biomedical Imaging, University of California, San Francisco, USA.
authors: Tracy L
authors: TL
authors: Luks
authors: Department of Psychiatry, UCSF Weill Institute for Neurosciences, University of California, San Francisco, USA.
authors: Karen
authors: K
authors: Lai
authors: Department of Psychiatry, UCSF Weill Institute for Neurosciences, University of California, San Francisco, USA.
authors: Ofilio
authors: O
authors: Vigil
authors: Department of Psychiatry, UCSF Weill Institute for Neurosciences, University of California, San Francisco, USA; Department of Psychiatry, San Francisco Veterans Affairs Medical Center, San Francisco, CA, USA.
authors: Sylvia
authors: S
authors: Guillory
authors: Department of Psychiatry, University of Florida, Gainesville, FL, USA; Department of Psychiatry, North Eastern Indira Gandhi Regional Institute of Health and Medical Sciences (NEIGRIHMS), Shillong, Meghalaya, India.
authors: Arvind
authors: A
authors: Nongpiur
authors: Department of Psychiatry, UCSF Weill Institute for Neurosciences, University of California, San Francisco, USA.
authors: Shiva M
authors: SM
authors: Fekri
authors: Department of Psychiatry, UCSF Weill Institute for Neurosciences, University of California, San Francisco, USA.
authors: Eve
authors: E
authors: Kupferman
authors: Department of Psychiatry, UCSF Weill Institute for Neurosciences, University of California, San Francisco, USA; Department of Psychiatry, San Francisco Veterans Affairs Medical Center, San Francisco, CA, USA.
authors: Daniel H
authors: DH
authors: Mathalon
authors: Department of Psychiatry, UCSF Weill Institute for Neurosciences, University of California, San Francisco, USA; Department of Psychiatry, University of Florida, Gainesville, FL, USA. Electronic address: carolmathews@ufl.edu.
authors: Carol A
authors: CA
authors: Mathews
mesh_terms: D000328:Adult; D000368:Aged; D001921:Brain / Q000000981:diagnostic imaging*; D056344:Executive Function / Q000502:physiology*; D005260:Female; D060845:Hoarding / Q000000981:diagnostic imaging* / Q000523:psychology; D000067836:Hoarding Disorder / Q000000981:diagnostic imaging* / Q000523:psychology; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009771:Obsessive-Compulsive Disorder / Q000000981:diagnostic imaging* / Q000523:psychology
keywords: Conflict monitoring; Go/No-go; Hoarding disorder; Neuroimaging; Response inhibition; Stroop; fMRI