title: Can mean platelet volume be used as a biomarker for asthma?
abstract: BACKGROUND
  Platelets play important roles in airway inflammation and are activated in inflammatory lung diseases, including asthma.
  
  
  OBJECTIVE
  We evaluated the mean platelet volume (MPV), used as a marker of platelet activation, in asthmatic patients during asymptomatic periods and exacerbations compared to healthy controls to determine whether MPV can be used as an indicator of inflammation.
  
  
  METHODS
  Our patient group consisted of 95 children with exacerbation of asthma who were admitted to our allergy clinic. The control group consisted of 100 healthy children matched for age, gender, and ethnicity. Mean platelet volume values of the patient group obtained during exacerbation of asthma were compared to those of the same group during the asymptomatic period and with the control group. We investigated factors that can affect the MPV values of asthma patients, including infection, atopy, immunotherapy treatment, and severity of asthma exacerbation.
  
  
  RESULTS
  The patient group consisted of 50 (52.6%) boys and 45 (47.4%) girls with a mean age of 125 ±38 months old. Mean MPV values in the exacerbation period, the healthy period, and in the control group were 8.1 ±0.8 fl, 8.1 ±1.06 fl, and 8.2 ±0.9 fl, respectively; there were no significant differences between groups (p > 0.05). The severity of asthma, severity of asthma exacerbation, immunotherapy, coinfection, eosinophil count, and IgE level also had no effect on MPV (p > 0.05).
  
  
  CONCLUSIONS
  Although platelets play a role in the pathophysiology of asthma, MPV measurement is insufficient to detect inflammation through platelets.
authors: Department of Pediatric Allergy, Dr. Behcet Uz Children's Hospital, Izmir, Turkey.
authors: Hikmet Tekin
authors: HT
authors: Nacaroglu
authors: Department of Pediatrics, Dr. Behcet Uz Children's Hospital, Izmir, Turkey.
authors: Rana
authors: R
authors: Isguder
authors: Department of Pediatric Allergy, Dr. Behcet Uz Children's Hospital, Izmir, Turkey.
authors: Semiha Erdem
authors: SE
authors: Bahceci
authors: Department of Pediatrics, Dr. Behcet Uz Children's Hospital, Izmir, Turkey.
authors: Gökhan
authors: G
authors: Ceylan
authors: Department of Pediatrics, Dr. Behcet Uz Children's Hospital, Izmir, Turkey.
authors: Huseyin Anil
authors: HA
authors: Korkmaz
authors: Department of Pediatric Allergy, Dr. Behcet Uz Children's Hospital, Izmir, Turkey.
authors: Sait
authors: S
authors: Karaman
authors: Department of Pediatric Allergy, Dr. Behcet Uz Children's Hospital, Izmir, Turkey.
authors: Canan Sule Unsal
authors: CS
authors: Karkıner
authors: Department of Pediatric Allergy, Dr. Behcet Uz Children's Hospital, Izmir, Turkey.
authors: Demet
authors: D
authors: Can
keywords: asthma; atopy; childhood; immunotherapy; mean platelet volume