title: When Hexokinase Gets that NAG-ing Feeling….
abstract: Immune cell recognition of bacterial products usually occurs via specific pattern recognition receptors, but new research recently published in Cell by Wolf et al. (2016) demonstrates that the glycolytic enzyme hexokinase can act as an innate immune sensor by binding to bacterial derived N-acetylglucosamine (NAG).
authors: Department of Immunometabolism, Max Planck Institute of Immunobiology and Epigenetics, 79108 Freiburg, Germany. Electronic address: osullivan@ie-freiburg.mpg.de.
authors: David
authors: D
authors: O'Sullivan
authors: Department of Immunometabolism, Max Planck Institute of Immunobiology and Epigenetics, 79108 Freiburg, Germany.
authors: Beth
authors: B
authors: Kelly
authors: Department of Immunometabolism, Max Planck Institute of Immunobiology and Epigenetics, 79108 Freiburg, Germany. Electronic address: pearce@ie-freiburg.mpg.de.
authors: Erika L
authors: EL
authors: Pearce
mesh_terms: D000117:Acetylglucosamine; D006019:Glycolysis; D006593:Hexokinase
chemical_list: D006593:Hexokinase; D000117:Acetylglucosamine