title: Prediction of Venous Thromboembolism after Total Knee Arthroplasty Using Dielectric Blood Coagulometry.
abstract: BACKGROUND
  Venous thromboembolism (VTE) including deep vein thrombosis (DVT) and pulmonary embolism (PE) frequently occurs in patients undergoing total knee arthroplasty (TKA). This study aimed to evaluate the efficacy of dielectric blood coagulometry (DBCM) as a new technique for predicting postoperative VTE.
  
  
  METHODS
  Thirty patients undergoing TKA were enrolled. DVT was diagnosed by ultrasonography preoperatively and on the fourth or fifth postoperative day. Enhanced computed tomography was performed to detect PE on the fourth postoperative day. The day after surgery, a blood sample was measured by DBCM. All patients received fondaparinux or low-molecular-weight heparin for postoperative thromboprophylaxis.
  
  
  RESULTS
  Eighteen of the 30 patients had DVT postoperatively, and 10 had asymptomatic PE. Seven patients had both DVT and PE. The patterns of permittivity as a function of time and frequency from the DBCM measurement were different between patients with and without VTE. The sensitivity and specificity of the parameter constructed from a set of permittivities at the frequencies of 2.5 kHz, 1 MHz, and 10 MHz were 90% and 78%, respectively.
  
  
  CONCLUSIONS
  DBCM was effective and efficient for predicting VTE after TKA.
authors: Department of Esophageal and General Surgery, Tokyo Medical and Dental University Graduate School, Tokyo, Japan. Electronic address: uchiyama.srg1@tmd.ac.jp.
authors: Hidetoshi
authors: H
authors: Uchiyama
authors: Department of Esophageal and General Surgery, Tokyo Medical and Dental University Graduate School, Tokyo, Japan.
authors: Yoshinori
authors: Y
authors: Inoue
authors: Department of Endocrinology and Metabolism, Tokyo Medical and Dental University Graduate School, Tokyo, Japan.
authors: Isao
authors: I
authors: Uchimura
authors: Department of Orthopaedic Surgery, Tokyo Medical and Dental University Hospital, Tokyo, Japan.
authors: Tomomasa
authors: T
authors: Nakamura
authors: Department of Esophageal and General Surgery, Tokyo Medical and Dental University Graduate School, Tokyo, Japan.
authors: Toshifumi
authors: T
authors: Kudo
authors: Department of Orthopaedic Surgery, Tokyo Medical and Dental University Hospital, Tokyo, Japan.
authors: Takeshi
authors: T
authors: Muneta
authors: Department of Esophageal and General Surgery, Tokyo Medical and Dental University Graduate School, Tokyo, Japan.
authors: Tatsuyuki
authors: T
authors: Kawano
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000925:Anticoagulants / Q000627:therapeutic use; D019645:Arthroplasty, Replacement, Knee / Q000009:adverse effects*; D001777:Blood Coagulation / Q000187:drug effects; D001780:Blood Coagulation Tests / Q000379:methods*; D000072226:Computed Tomography Angiography; D058266:Dielectric Spectroscopy; D005240:Feasibility Studies; D005260:Female; D000077425:Fondaparinux; D006495:Heparin, Low-Molecular-Weight / Q000627:therapeutic use; D006801:Humans; D008297:Male; D011134:Polysaccharides / Q000627:therapeutic use; D011237:Predictive Value of Tests; D011655:Pulmonary Embolism / Q000097:blood / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000517:prevention & control; D012307:Risk Factors; D013997:Time Factors; D016896:Treatment Outcome; D014463:Ultrasonography; D054556:Venous Thromboembolism / Q000097:blood / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000517:prevention & control; D020246:Venous Thrombosis / Q000097:blood / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000517:prevention & control
chemical_list: D000925:Anticoagulants; D006495:Heparin, Low-Molecular-Weight; D011134:Polysaccharides; D000077425:Fondaparinux