title: Systematic Review and Meta-Analysis of Doxycycline Efficacy for Rectal Lymphogranuloma Venereum in Men Who Have Sex with Men.
abstract: Rectal lymphogranuloma venereum (LGV) has reemerged as a sexually transmitted infection among men who have sex with men (MSM), particularly those who are HIV-positive. We undertook a systematic review and meta-analysis to determine the efficacy of doxycycline (100 mg 2×/d for 21 days) for rectal LGV in MSM. Nine studies were included: 4 prospective, 4 retrospective, and 1 combined retrospective and prospective. In total, 282 MSM with rectal LGV were included in the studies. All studies reported using nucleic acid amplification tests to assess microbial cure. Most patients (>80%) had symptomatic rectal infection. The fixed-effects pooled efficacy for doxycycline was 98.5% (95% CI 96.3%-100%, I (2)  = 0%; p = 0.993). Doxycycline at 100 mg twice daily for 21 days demonstrated a high microbial cure rate. These data support doxycycline at this dosage and duration as first-line therapy for rectal LGV in MSM.
authors: Charussri
authors: C
authors: Leeyaphan
authors: Jason J
authors: JJ
authors: Ong
authors: Eric P F
authors: EP
authors: Chow
authors: Fabian Y S
authors: FY
authors: Kong
authors: Jane S
authors: JS
authors: Hocking
authors: Melanie
authors: M
authors: Bissessor
authors: Christopher K
authors: CK
authors: Fairley
authors: Marcus
authors: M
authors: Chen
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D002692:Chlamydia trachomatis; D004318:Doxycycline / Q000627:therapeutic use*; D018451:Homosexuality, Male; D006801:Humans; D008219:Lymphogranuloma Venereum / Q000188:drug therapy*; D008297:Male; D012002:Rectal Diseases / Q000188:drug therapy*; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents; D004318:Doxycycline
keywords: Chlamydia trachomatis; STI; bacteria; chlamydia; doxycycline; efficacy; men who have sex with men; meta-analysis; rectal lymphogranuloma venereum; sexually transmitted infection; systematic review; treatment