title: Association of serum chemerin concentrations with the presence of atrial fibrillation.
abstract: Objective Chemerin, a newly discovered adipokine, is correlated with hypertension, diabetes and coronary heart disease. The aim of this study is to investigate the association of serum chemerin concentrations with the presence of atrial fibrillation. Methods Serum chemerin concentrations were determined in 256 patients with atrial fibrillation and 146 healthy subjects. Atrial fibrillation patients were then divided into paroxysmal, persistent and permanent atrial fibrillation. Results Serum chemerin concentrations were significantly higher in atrial fibrillation patients compared with healthy controls. In subgroup studies, patients with permanent atrial fibrillation had higher serum chemerin concentrations than those with persistent and paroxysmal atrial fibrillation. Furthermore, significant higher serum chemerin concentrations were observed in persistent atrial fibrillation patients compared with paroxysmal atrial fibrillation subjects. Serum chemerin concentrations were associated with the presence of atrial fibrillation after logistic regression analysis. Pearson correlation analysis revealed a positive relation of serum chemerin concentrations with body mass index, systolic blood pressure, diastolic blood pressure, triglycerides, low-density lipoprotein cholesterol, blood urea nitrogen, creatinine, C-reactive protein and left atrial diameter. Conclusion Serum chemerin concentrations are associated with the presence of atrial fibrillation and atrial remodelling.
authors: 1 Department of Cardiac Surgery, The First Affiliated Hospital of Harbin Medical University, Harbin, China.
authors: Guowei
authors: G
authors: Zhang
authors: 2 Department of Cardiology, The Fourth Affiliated Hospital of Harbin Medical University, Harbin, China.
authors: Mochao
authors: M
authors: Xiao
authors: 2 Department of Cardiology, The Fourth Affiliated Hospital of Harbin Medical University, Harbin, China.
authors: Lili
authors: L
authors: Zhang
authors: 2 Department of Cardiology, The Fourth Affiliated Hospital of Harbin Medical University, Harbin, China.
authors: Yue
authors: Y
authors: Zhao
authors: 2 Department of Cardiology, The Fourth Affiliated Hospital of Harbin Medical University, Harbin, China.
authors: Qinghui
authors: Q
authors: Yang
mesh_terms: D000368:Aged; D001281:Atrial Fibrillation / Q000097:blood / Q000145:classification / Q000000981:diagnostic imaging* / Q000503:physiopathology; D015415:Biomarkers / Q000097:blood; D001794:Blood Pressure; D001806:Blood Urea Nitrogen; D015992:Body Mass Index; D002097:C-Reactive Protein / Q000378:metabolism; D018925:Chemokines / Q000097:blood*; D003404:Creatinine / Q000097:blood; D003430:Cross-Sectional Studies; D005260:Female; D006325:Heart Atria / Q000000981:diagnostic imaging* / Q000503:physiopathology; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000097:blood*; D008077:Lipoproteins, LDL / Q000097:blood; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D014280:Triglycerides / Q000097:blood
chemical_list: D015415:Biomarkers; D018925:Chemokines; D036341:Intercellular Signaling Peptides and Proteins; D008077:Lipoproteins, LDL; C478630:RARRES2 protein, human; D014280:Triglycerides; D002097:C-Reactive Protein; D003404:Creatinine
keywords: Chemerin; atrial fibrillation; left atrial diameter