title: Mucormycosis: a 10-year experience at a tertiary care center in Turkey.
abstract: OBJECTIVE
  Mucormycosis is a rare invasive fungal infection most commonly encountered in the immunocompromised host. We analyzed 51 adult patients treated for mucormycosis between 2003 and 2013 and recorded at a tertiary university hospital in Turkey.
  
  
  METHODS
  We examined the following data for all patients: age, sex, predisposing disease, symptoms, treatment, surgical procedure, concomitant infections, intensive care requirement, and outcomes.
  
  
  RESULTS
  During the study period 51 cases of mucormycosis were documented; 54.9% of the patients were female. The mean age was 44.2 ± 18.2 years. Rhinocerebral presentation was reported in 94.1% of patients. Almost all patients (88.2%) had at least one risk factor. The common predisposing factors were hematologic malignancies (52.9%), diabetes mellitus (25.5%), and solid malignancies (5.8%). The most common initial symptoms were fever, cellulitis, and facial pain. The primary medication used was liposomal amphotericin B or conventional amphotericin B. Surgery was performed in 94.1% of patients. Mortality was 52.9%.
  
  
  CONCLUSIONS
  Our study revealed that mucormycosis continues to be a mortal disease in about half of the cases. Our findings indicate that treatment with L-AMB is associated with a favorable response. Also, in the case of facial pain, the low mortality rate may indicate the importance of early diagnosis.
authors: Department of Infectious Diseases, Faculty of Medicine, Çukurova University, Adana, Turkey.
authors: Süheyla
authors: S
authors: Kömür
authors: Department of Infectious Diseases, Faculty of Medicine, Çukurova University, Adana, Turkey.
authors: Ayşe Seza
authors: AS
authors: İnal
authors: Department of Infectious Diseases, Faculty of Medicine, Çukurova University, Adana, Turkey.
authors: Behice
authors: B
authors: Kurtaran
authors: Department of Infectious Diseases, Faculty of Medicine, Çukurova University, Adana, Turkey.
authors: Aslıhan
authors: A
authors: Ulu
authors: Department of Pathology, Faculty of Medicine, Çukurova University, Adana, Turkey.
authors: Aysun
authors: A
authors: Uğuz
authors: Department of Infectious Diseases, Faculty of Medicine, Çukurova University, Adana, Turkey.
authors: Hasan Salih Zeki
authors: HS
authors: Aksu
authors: Department of Infectious Diseases, Faculty of Medicine, Çukurova University, Adana, Turkey.
authors: Yeşim
authors: Y
authors: Taşova
mesh_terms: D000328:Adult; D000935:Antifungal Agents; D005260:Female; D006801:Humans; D016867:Immunocompromised Host; D008297:Male; D008875:Middle Aged; D009091:Mucormycosis; D062606:Tertiary Care Centers; D014421:Turkey
chemical_list: D000935:Antifungal Agents
keywords: Facial pain; fever; liposomal amphotericin; mucormycosis