title: Herpetic tracheitis in association with rituximab therapy.
abstract: A 58-year old lady under active follow-up with the respiratory services at our institution for bronchiectasis secondary to hypogammaglobulinaemia presented with hoarseness and haemoptysis. She was also receiving rituximab maintenance therapy for follicular lymphoma. Bronchoscopy demonstrated vesicular lesions on her vocal cords and trachea, confirmed as herpes simplex virus (HSV) on cytological analysis of brushings. She responded well to intravenous valacyclovir. Rituximab is increasingly utilised in the treatment of haematological and auto-immune disorders. This case highlights the potential of this drug to potentiate susceptibility to infection in an already immunocompromised individual.
authors: Department of Respiratory Medicine Cork University Hospital Cork Ireland.
authors: Lorraine
authors: L
authors: Thong
authors: Department of Respiratory Medicine Cork University Hospital Cork Ireland.
authors: Barry J
authors: BJ
authors: Plant
authors: Department of Cytopathology Cork University Hospital Cork Ireland.
authors: Julie
authors: J
authors: McCarthy
authors: Department of Respiratory Medicine Cork University Hospital Cork Ireland.
authors: Desmond M
authors: DM
authors: Murphy
keywords: Herpes simplex; immunosuppression; non‐Hodgkin's lymphoma; rituximab; tracheitis