title: Imaging biomarkers for steatohepatitis and fibrosis detection in non-alcoholic fatty liver disease.
abstract: There is a need, in NAFLD management, to develop non-invasive methods to detect steatohepatitis (NASH) and to predict advanced fibrosis stages. We evaluated a tool based on optical analysis of liver magnetic resonance images (MRI) as biomarkers for NASH and fibrosis detection by investigating patients with biopsy-proven NAFLD who underwent magnetic resonance (MR) protocols using 1.5T General Electric (GE) or Philips devices. Two imaging biomarkers (NASHMRI and FibroMRI) were developed, standardised and validated using area under the receiver operating characteristic curve (AUROC) analysis. The results indicated NASHMRI diagnostic accuracy for steatohepatitis detection was 0.83 (95% CI: 0.73-0.93) and FibroMRI diagnostic accuracy for significant fibrosis determination was 0.85 (95% CI: 0.77-0.94). These findings were independent of the MR system used. We conclude that optical analysis of MRI has high potential to define non-invasive imaging biomarkers for the detection of steatohepatitis (NASHMRI) and the prediction of significant fibrosis (FibroMRI) in NAFLD patients.
authors: UCM Digestive Diseases and CIBEREHD, Virgen Macarena-Virgen del Rocío University Hospitals, University of Sevilla, Sevilla, 41013, Spain.|Instituto de Biomedicina de Sevilla (IBiS), University of Sevilla, Sevilla, 41013, Spain.
authors: Rocío
authors: R
authors: Gallego-Durán
authors: Group of Interdisciplinary Physics, Engineering School, University of Sevilla, Sevilla, 41092, Spain.
authors: Pablo
authors: P
authors: Cerro-Salido
authors: Group of Interdisciplinary Physics, Engineering School, University of Sevilla, Sevilla, 41092, Spain.
authors: Emilio
authors: E
authors: Gomez-Gonzalez
authors: Pathology Unit, Valme University Hospital, University of Sevilla, Sevilla, 41014, Spain.
authors: María Jesús
authors: MJ
authors: Pareja
authors: UCM Digestive Diseases and CIBEREHD, Virgen Macarena-Virgen del Rocío University Hospitals, University of Sevilla, Sevilla, 41013, Spain.|Instituto de Biomedicina de Sevilla (IBiS), University of Sevilla, Sevilla, 41013, Spain.
authors: Javier
authors: J
authors: Ampuero
authors: UCM Digestive Diseases and CIBEREHD, Virgen Macarena-Virgen del Rocío University Hospitals, University of Sevilla, Sevilla, 41013, Spain.|Instituto de Biomedicina de Sevilla (IBiS), University of Sevilla, Sevilla, 41013, Spain.
authors: María Carmen
authors: MC
authors: Rico
authors: Radiology Unit, Valme University Hospital, University of Sevilla, Sevilla, 41014, Spain.
authors: Rafael
authors: R
authors: Aznar
authors: UCM Digestive Diseases and CIBEREHD, Virgen Macarena-Virgen del Rocío University Hospitals, University of Sevilla, Sevilla, 41013, Spain.|Instituto de Biomedicina de Sevilla (IBiS), University of Sevilla, Sevilla, 41013, Spain.
authors: Eduardo
authors: E
authors: Vilar-Gomez
authors: Medical Sciences, University of Torino, Torino, 10126, Italy.
authors: Elisabetta
authors: E
authors: Bugianesi
authors: IDIVAL, Marqués de Valdecilla University Hospital, Gastroenterology and Hepatology Service, Santander, Spain.
authors: Javier
authors: J
authors: Crespo
authors: Radiology Unit, Marqués de Valdecilla University Hospital, Santander, 39008, Spain.
authors: Francisco José
authors: FJ
authors: González-Sánchez
authors: UCM Digestive Diseases, Valme University Hospital, Sevilla, 41014, Spain.
authors: Reyes
authors: R
authors: Aparcero
authors: UCM Digestive Diseases and CIBEREHD, Virgen de la Victoria University Hospital, Málaga, 29010, Spain.
authors: Inmaculada
authors: I
authors: Moreno
authors: UCM Digestive Diseases, Tajo University Hospital, Madrid, 28300, Spain.
authors: Susana
authors: S
authors: Soto
authors: IDIVAL, Marqués de Valdecilla University Hospital, Gastroenterology and Hepatology Service, Santander, Spain.
authors: María Teresa
authors: MT
authors: Arias-Loste
authors: UCM Digestive Diseases, Puerta de Hierro University Hospital, Madrid, 28222, Spain.
authors: Javier
authors: J
authors: Abad
authors: UCM Digestive Diseases and CIBEREHD, Virgen Macarena-Virgen del Rocío University Hospitals, University of Sevilla, Sevilla, 41013, Spain.|Instituto de Biomedicina de Sevilla (IBiS), University of Sevilla, Sevilla, 41013, Spain.
authors: Isidora
authors: I
authors: Ranchal
authors: UCM Digestive Diseases and CIBEREHD, Virgen de la Victoria University Hospital, Málaga, 29010, Spain.
authors: Raúl Jesús
authors: RJ
authors: Andrade
authors: UCM Digestive Diseases, Puerta de Hierro University Hospital, Madrid, 28222, Spain.
authors: Jose Luis
authors: JL
authors: Calleja
authors: Radiology Unit, Puerta de Hierro University Hospital, Madrid, 28222, Spain.
authors: Miguel
authors: M
authors: Pastrana
authors: UCM Digestive Diseases, Tajo University Hospital, Madrid, 28300, Spain.
authors: Oreste Lo
authors: OL
authors: Iacono
authors: UCM Digestive Diseases and CIBEREHD, Virgen Macarena-Virgen del Rocío University Hospitals, University of Sevilla, Sevilla, 41013, Spain.|Instituto de Biomedicina de Sevilla (IBiS), University of Sevilla, Sevilla, 41013, Spain.
authors: Manuel
authors: M
authors: Romero-Gómez
mesh_terms: D000328:Adult; D000368:Aged; D019540:Area Under Curve; D015415:Biomarkers / Q000378:metabolism*; D054459:Elasticity Imaging Techniques; D005234:Fatty Liver / Q000000981:diagnostic imaging / Q000473:pathology*; D005260:Female; D006801:Humans; D053538:Keratin-18 / Q000378:metabolism; D008099:Liver / Q000000981:diagnostic imaging / Q000473:pathology; D008103:Liver Cirrhosis / Q000150:complications / Q000000981:diagnostic imaging / Q000473:pathology*; D008279:Magnetic Resonance Imaging / Q000592:standards; D008297:Male; D008875:Middle Aged; D065626:Non-alcoholic Fatty Liver Disease / Q000150:complications / Q000000981:diagnostic imaging / Q000473:pathology*; D012372:ROC Curve; D012720:Severity of Illness Index
chemical_list: D015415:Biomarkers; D053538:Keratin-18