title: Spatiotemporal regulation of enhancers during cardiogenesis.
abstract: With the advance in chromatin immunoprecipitation followed by high-throughput sequencing, there has been a dramatic increase in our understanding of distal enhancer function. In the developing heart, the identification and characterisation of such enhancers have deepened our knowledge of the mechanisms of transcriptional regulation that drives cardiac differentiation. With next-generation sequencing techniques becoming widely accessible, the quantity of data describing the genome-wide distribution of cardiac-specific transcription factor and chromatin modifiers has rapidly increased and it is now becoming clear that the usage of enhancers is highly dynamic and complex, both during the development and in the adult. The identification of those enhancers has revealed new insights into the transcriptional mechanisms of how tissue-specific gene expression patterns are established, maintained, and change dynamically during development and upon physiological stress.
authors: The Francis Crick Institute, Mill Hill Laboratory, The Ridgeway, Mill Hill, London, NW7 1AA, UK. laurent.dupays@crick.ac.uk.
authors: Laurent
authors: 0000-0003-0812-7404
authors: L
authors: Dupays
authors: The Francis Crick Institute, Mill Hill Laboratory, The Ridgeway, Mill Hill, London, NW7 1AA, UK.
authors: Timothy
authors: T
authors: Mohun
mesh_terms: D000818:Animals; D004742:Enhancer Elements, Genetic; D018507:Gene Expression Regulation, Developmental; D006321:Heart / Q000196:embryology*; D006801:Humans; D008954:Models, Biological; D038081:Organogenesis / Q000235:genetics*; D013223:Statistics as Topic
keywords: Development; Embryonic stem cell; Heart; Transcription