title: The effect of chitosan-based gel on second degree burn wounds.
abstract: OBJECTIVE
  Chitosan has been widely used in wound healing, including burn wounds. ChitoHeal gel, a novel chitosan-based gel, is studied to assess the effectiveness and rate of wound healing in second degree burns compared with traditional wound dressings.
  
  
  METHODS
  New Zealand rabbits were divided into two groups, control and treatment. Second degree burn wounds were created using a hot round aluminium stamp. It was heated up to 80°C and applied 14 seconds without additional pressure. Morphological, histological, and molecular parameters were used to evaluate the effects of the chitosan-based gel on burn healing.
  
  
  RESULTS
  The study exhibited that in the control group with an increase in the number of keratinocytes due to the papillary growth of the epidermis, melanocyte pigmentation increased, and some melanin was observed in the dermis. In the treatment group, however, there was no hyper pigmentation nor overgrowth of the epidermis. Transmission electron microscopy micrographs of healed epidermis in treatment group showed melanocyte with normal morphology.
  
  
  CONCLUSIONS
  The result of the present study is likely to be important for the development of novel strategies for wound healing using chitosan gel.
authors: Biomaterial Group, Medical Engineering Department, Amirkabir University of Technology, Tehran, Iran.
authors: S
authors: S
authors: Honardar
authors: Biomaterial Group, Medical Engineering Department, Amirkabir University of Technology, Tehran, Iran.|ChitoTech Company, Khaghani Building, Somayrh Avenue, Tehran, Iran.
authors: S S
authors: SS
authors: Kordestani
authors: National Institute of Genetic Engineering and Biotechnology, Tehran, Iran.
authors: M
authors: M
authors: Daliri
authors: Biomaterial Group, Medical Engineering Department, Amirkabir University of Technology, Tehran, Iran.
authors: F
authors: F
authors: NayebHabib
mesh_terms: D000818:Animals; D002056:Burns / Q000188:drug therapy*; D048271:Chitosan / Q000627:therapeutic use*; D004195:Disease Models, Animal; D005782:Gels / Q000627:therapeutic use*; D006801:Humans; D011817:Rabbits; D014945:Wound Healing / Q000187:drug effects*
chemical_list: D005782:Gels; D048271:Chitosan
keywords: ChitoHeal gel; burn; hyper pigmentation; melanocyte; structure change