title: NIAS-Server: Neighbors Influence of Amino acids and Secondary Structures in Proteins.
abstract: The exponential growth in the number of experimentally determined three-dimensional protein structures provide a new and relevant knowledge about the conformation of amino acids in proteins. Only a few of probability densities of amino acids are publicly available for use in structure validation and prediction methods. NIAS (Neighbors Influence of Amino acids and Secondary structures) is a web-based tool used to extract information about conformational preferences of amino acid residues and secondary structures in experimental-determined protein templates. This information is useful, for example, to characterize folds and local motifs in proteins, molecular folding, and can help the solution of complex problems such as protein structure prediction, protein design, among others. The NIAS-Server and supplementary data are available at http://sbcb.inf.ufrgs.br/nias .
authors: 1 Institute of Informatics, Federal University of Rio Grande do Sul , Porto Alegre, Brazil .
authors: Bruno
authors: B
authors: Borguesan
authors: 2 Departamento de Ingeniería Informática, Center for Biotechnology and Bioengineering , Universidad de Santiago de Chile, Santiago, Chile .
authors: Mario
authors: M
authors: Inostroza-Ponta
authors: 1 Institute of Informatics, Federal University of Rio Grande do Sul , Porto Alegre, Brazil .
authors: Márcio
authors: M
authors: Dorn
mesh_terms: D000465:Algorithms; D020816:Amino Acid Motifs; D000596:Amino Acids / Q000737:chemistry*; D019295:Computational Biology / Q000379:methods*; D030562:Databases, Protein; D020407:Internet; D008958:Models, Molecular; D017510:Protein Folding; D017433:Protein Structure, Secondary; D011506:Proteins / Q000737:chemistry*; D012984:Software
chemical_list: D000596:Amino Acids; D011506:Proteins
keywords: conformational preferences; structural biology; three-dimensional structure of proteins