title: Karyomegalic interstitial nephropathy following ifosfamide therapy.
abstract: Ifosfamide (IFO), an alkylating agent used for the management of solid organ tumors, can cause reversible Fanconi's syndrome and acute kidney injury. Karyomegalic interstitial nephropathy (KIN) is a rare form of chronic tubulointerstitial nephritis, initially described as a familial nephropathy in adults. So far, four cases of KIN have been reported in pediatric and adolescent population following treatment with IFO. We report a 22-year-old man who developed renal dysfunction following IFO therapy for relapsed Hodgkin's lymphoma. Renal biopsy revealed chronic tubulointerstitial nephritis with atypical tubular epithelial cells showing nuclear enlargement and hyperchromasia, consistent with a diagnosis of KIN. The renal function improved following a short course of corticosteroids.
authors: Department of Nephrology, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India.
authors: R
authors: R
authors: Jayasurya
authors: Department of Pathology, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India.
authors: B H
authors: BH
authors: Srinivas
authors: Department of Medical Oncology, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India.
authors: M
authors: M
authors: Ponraj
authors: Department of Nephrology, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India.
authors: S
authors: S
authors: Haridasan
authors: Department of Nephrology, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India.
authors: S
authors: S
authors: Parameswaran
authors: Department of Nephrology, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India.
authors: P S
authors: PS
authors: Priyamvada
keywords: Cancer chemotherapy; chronic interstitial nephritis; karyomegaly