title: Combinatorial Tethering: A Novel Mode to Recruit Non-canonical PRC1 for Normal and Malignant GC B Cell Development.
abstract: Polycomb repressive complexes (PRCs) are key to normal development and are frequently deregulated in human cancer. In this issue of Cancer Cell, Béguelin et al. report a mechanism of non-canonical PRC1 recruitment by BCL6 in collaboration with EZH2-mediated H3K27me3 for establishment of stable repressive complexes in germinal center B cells.
authors: Division of Cancer Studies, Department of Haematological Medicine, Leukaemia and Stem Cell Biology Group, King's College London, Denmark Hill, SE5 9NU London, UK.
authors: Bernd B
authors: BB
authors: Zeisig
authors: Division of Cancer Studies, Department of Haematological Medicine, Leukaemia and Stem Cell Biology Group, King's College London, Denmark Hill, SE5 9NU London, UK. Electronic address: eric.so@kcl.ac.uk.
authors: Chi Wai Eric
authors: CWE
authors: So
mesh_terms: D001402:B-Lymphocytes; D018858:Germinal Center; D006801:Humans; D063146:Polycomb-Group Proteins
chemical_list: D063146:Polycomb-Group Proteins