title: The role of IL-25 and IL-33 in chronic rhinosinusitis with or without nasal polyps.
abstract: The role of IL-25 and IL-33 in the aetiology and pathogenesis of nasal polyps has been controversial in the literature. The objective of the study is to detect serum and tissue levels of IL-25 and IL-33 in patients with (CRSwNP) or without (CRSsNP) nasal polyps using enzyme-linked immunosorbent assay (ELISA). Study group consisted of 20 CRSwNP and 20 CRSsNP patients. Control group comprised of 20 volunteers who had been operated with septum deviation without any additional sinonasal pathology, allergy, systemic disease, or medication use. All groups preoperatively underwent paranasal CT examinations and sinonasal pathologies were recorded based on Lund-Mackay radiological staging system. IL-25 and IL-33 levels in serum and tissue samples were analyzed using the ELISA method. Serum IL-25 and IL-33 levels in CRSsNP, CRSwNP, and control groups did not differ statistically significantly (p = 0.345 and p = 0.338). Any statistically significant difference was not detected in mean tissue IL-25 levels among CRSsNP, CRSwNP, and control groups (p = 0.698). Mean tissue IL-33 level in the CRSwNP group was statistically significantly lower when compared with those of CRSsNP and control groups (p < 0.001 and p < 0.001, respectively). A statistically significant negative correlation was detected between tissue IL-33 levels and Lund-Mackay CT scores (r = -0.436 and p = 0.005). In the present study, we conceivably contributed to scarce number of studies conducted on this issue and we think that further studies will better clarify the role of IL-25 and IL-33 in the development of nasal polyps.
authors: Department of ENT, Antalya Research and Education Hospital, Varlık Mh. Kazim Karabekir Caddesi, Muratpaşa, 07100, Antalya, Turkey.
authors: Atakan
authors: A
authors: Ozturan
authors: Department of ENT, Antalya Research and Education Hospital, Varlık Mh. Kazim Karabekir Caddesi, Muratpaşa, 07100, Antalya, Turkey. hulinar@yahoo.com.
authors: Hulya
authors: H
authors: Eyigor
authors: Department of Medical Microbiology Antalya, Akdeniz University Medical Faculty, Antalya, Turkey.
authors: Mete
authors: M
authors: Eyigor
authors: Department of ENT, Antalya Research and Education Hospital, Varlık Mh. Kazim Karabekir Caddesi, Muratpaşa, 07100, Antalya, Turkey.
authors: Ustun
authors: U
authors: Osma
authors: Department of ENT, Antalya Research and Education Hospital, Varlık Mh. Kazim Karabekir Caddesi, Muratpaşa, 07100, Antalya, Turkey.
authors: Mustafa Deniz
authors: MD
authors: Yilmaz
authors: Department of ENT, Antalya Research and Education Hospital, Varlık Mh. Kazim Karabekir Caddesi, Muratpaşa, 07100, Antalya, Turkey.
authors: Omer Tarik
authors: OT
authors: Selcuk
authors: Department of ENT, Antalya Research and Education Hospital, Varlık Mh. Kazim Karabekir Caddesi, Muratpaşa, 07100, Antalya, Turkey.
authors: Levent
authors: L
authors: Renda
authors: Department of Medical Microbiology Antalya, Akdeniz University Medical Faculty, Antalya, Turkey.
authors: Meral
authors: M
authors: Gultekin
mesh_terms: D000328:Adult; D000368:Aged; D002908:Chronic Disease; D005260:Female; D006801:Humans; D020381:Interleukin-17 / Q000032:analysis / Q000378:metabolism; D000067596:Interleukin-33 / Q000032:analysis / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D009297:Nasal Mucosa / Q000378:metabolism / Q000473:pathology; D009298:Nasal Polyps / Q000378:metabolism / Q000473:pathology; D012220:Rhinitis / Q000378:metabolism / Q000473:pathology; D012852:Sinusitis / Q000378:metabolism / Q000473:pathology; D013223:Statistics as Topic; D014421:Turkey
chemical_list: D020381:Interleukin-17; D000067596:Interleukin-33
keywords: Chronic rhinosinusitis; ELISA; IL-25; IL-33; Nasal polyps