title: The value of histopathological diagnosis in the elderly patients with granulomatous dermatoses. Case series.
abstract: Granulomatous inflammations are a particular type of chronic septic or aseptic inflammation, in which infectious or non-infectious agents are difficult to eliminate by the immune system. These are type IV hypersensitivity reactions mediated by pre-sensitized T-lymphocytes cells CD4+ and CD8+ lymphocytes. Disorders included in this category are: tuberculosis, leprosy, syphilis, sarcoidosis, type I diabetes, multiple sclerosis, Crohn's disease and rheumatoid arthritis. At cutaneous level, this pattern of granulomatous reaction is characterized by a chronic inflammation with formation of granulomas consisting of a variable number of histiocytes, multinucleated giant cells and lymphocytes. Granulomatous dermatoses should be differentiated from other primary or secondary lesions affecting the skin such as inflammation or tumors. Often granulomatous dermatoses can be confused with other skin disorders, both clinically and histological. Histopathology examination can add important information and clarify the diagnosis. This paper presents a series of three clinical cases of granulomatous skin occurring in the elderly patients confirmed at histology examination. Clinical and histology criteria were analyzed, along with specific differential diagnosis, based on data from the literature.
authors: Department of Public Health, University of Medicine and Pharmacy of Tirgu Mures, Romania; florin_buicu@yahoo.com.
authors: Mihail Alexandru
authors: MA
authors: Badea
authors: Corneliu Florin
authors: CF
authors: Buicu
authors: Anca Ileana
authors: AI
authors: Sin
authors: Ovidiu Simion
authors: OS
authors: Cotoi
authors: Iudita Maria
authors: IM
authors: Badea
authors: Andreea Luciana
authors: AL
authors: Chiotoroiu
authors: Silviu Horia
authors: SH
authors: Morariu
mesh_terms: D000368:Aged; D003937:Diagnosis, Differential; D004890:Erythema / Q000473:pathology; D005260:Female; D006099:Granuloma / Q000175:diagnosis* / Q000473:pathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012871:Skin Diseases / Q000175:diagnosis* / Q000473:pathology*