title: Diagnostic Accuracy of Perfusion Computed Tomography in Cerebral Glioma Grading.
abstract: OBJECTIVE
  To determine the diagnostic accuracy of perfusion computed tomography (PCT) in the grading of cerebral glioma.
  
  
  METHODS
  Cross-sectional analytical study.
  
  
  METHODS
  Department of Radiology, Allied Hospital, Faisalabad, from January to June 2014.
  
  
  METHODS
  All the patients with untreated glioma had an initial non-contrast head CT and then PCT using 128 multidetector CTscanner. Perfusion maps of permeability surface (PS) and cerebral blood volume (CBV) were generated and measured. As control, a second volume of interest was placed in the contralateral healthy cortex. PCT parameters were compared with World Health Organization (WHO) glioma grades.
  
  
  RESULTS
  Fifty patients of 30 - 70 years of age of both genders (mean 45.13 ±5.54), 31 (62%) males and 19 (38%) females were studied. These patients were classified as low-grade glioma group (22 patients) and high-grade glioma group (28 patients). PS showed the sensitivity of 95.45%, specificity of 92.86% and diagnostic accuracy of 94% in differentiating the low-grade and high-grade glioma by using a cut-off value of 3.6 ml/100 g/minute. By using a cut-off value of CBV of 2.08 (ml/100 g) among low-grade and high-grade glioma group, CBV showed the sensitivity of 77.3%, specificity of 89.3%, and diagnostic accuracy of 84%.
  
  
  CONCLUSIONS
  The derived parameters (PS and CBV) correlate well with tumor histopathology, differentiating low-grade from high-grade gliomas. PS showed better accuracy for glioma grading.
authors: Department of Radiology, PMC, Allied Hospital, Faisalabad.
authors: Nosheen
authors: N
authors: Ahmad
authors: Department of Radiology, PMC, Allied Hospital, Faisalabad.
authors: Asim
authors: A
authors: Shaukat
authors: Department of Radiology, PMC, Allied Hospital, Faisalabad.
authors: Amna
authors: A
authors: Rehan
authors: Department of Radiology, PMC, Allied Hospital, Faisalabad.
authors: Shamoona
authors: S
authors: Rashid
mesh_terms: D000328:Adult; D000368:Aged; D001783:Blood Flow Velocity; D001810:Blood Volume; D001932:Brain Neoplasms / Q000098:blood supply / Q000000981:diagnostic imaging* / Q000473:pathology*; D002199:Capillary Permeability; D002560:Cerebrovascular Circulation / Q000502:physiology; D003430:Cross-Sectional Studies; D005260:Female; D005910:Glioma / Q000098:blood supply / Q000000981:diagnostic imaging* / Q000473:pathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D061330:Multidetector Computed Tomography; D060787:Neoplasm Grading; D055420:Perfusion Imaging / Q000379:methods*; D011237:Predictive Value of Tests; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity