title: Development of an Algorithm to Perform a Comprehensive Study of Autonomic Dysreflexia in Animals with High Spinal Cord Injury Using a Telemetry Device.
abstract: Spinal cord injury (SCI) is a debilitating neurological condition characterized by somatic and autonomic dysfunctions. In particular, SCI above the mid-thoracic level can lead to a potentially life-threatening hypertensive condition called autonomic dysreflexia (AD) that is often triggered by noxious or non-noxious somatic or visceral stimuli below the level of injury. One of the most common triggers of AD is the distension of pelvic viscera, such as during bladder and bowel distension or evacuation. This protocol presents a novel pattern recognition algorithm developed for a JAVA platform software to study the fluctuations of cardiovascular parameters as well as the number, severity and duration of spontaneously occurring AD events. The software is able to apply a pattern recognition algorithm on hemodynamic data such as systolic blood pressure (SBP) and heart rate (HR) extracted from telemetry recordings of conscious and unrestrained animals before and after thoracic (T3) complete transection. With this software, hemodynamic parameters and episodes of AD are able to be detected and analyzed with minimal experimenter bias.
authors: International Collaboration on Repair Discoveries (ICORD), Faculty of Medicine, University of British Columbia; davidpopok@gmail.com.
authors: David
authors: D
authors: Popok
authors: International Collaboration on Repair Discoveries (ICORD), Faculty of Medicine, University of British Columbia.
authors: Christopher
authors: C
authors: West
authors: International Collaboration on Repair Discoveries (ICORD), Faculty of Medicine, University of British Columbia.
authors: Barbara
authors: B
authors: Frias
authors: International Collaboration on Repair Discoveries (ICORD), Faculty of Medicine, University of British Columbia; Department of Medicine, Division of Physical Medicine and Rehabilitation, University of British Columbia, GF Strong Rehabilitation Centre.
authors: Andrei V
authors: AV
authors: Krassioukov
mesh_terms: D000465:Algorithms; D000818:Animals; D020211:Autonomic Dysreflexia; D001794:Blood Pressure; D013116:Spinal Cord; D013119:Spinal Cord Injuries; D013686:Telemetry