title: [The Emergence of Ebola virus in humans: a long process not yet fully understood].
abstract: Since 1976 Ebola virus regularly has caused small deadly outbreaks in Central Africa, usually controlled in a few months. For the first time, an Ebola epidemic of exceptional magnitude dramatically engulfed several countries in West Africa since December 2013. Major failures of implementing measures to prevent human-to-human transmissions are the main cause of this large-scale Ebola outbreak. After about one-week incubation period, the Ebola virus disease is characterized by a sudden onset of high fever leading to multiple hemorrhages and to widespread organ failure. Several bat species constitute the main reservoirs of Ebola viruses. Human contamination would occur either directly from bats, widely consumed by the local populations, or through animal species susceptible to Ebola infection, such as chimpanzees and gorillas. Alongside this "natural cycle", an "epidemic cycle" involving domestic animals living in villages such as dogs or pigs, is seriously suggested. Thus, according to the diversity of concerned animals and their clinical infectionform, modalities of human contamination can be multiple and are still largely unknown. In this context, all efforts that could be made to unravel the mystery of the Ebola virus emergence in humans and clarify modalities of the virus transmission, would allow for predicting or for anticipating the future occurrence of epidemics. This review aims to provide an exhaustive inventory of the Ebola ecology to highlight events governing the virus transmission to humans that still remain unsolved.
authors: Éric Maurice
authors: ÉM
authors: Leroy
mesh_terms: D000818:Animals; D021821:Communicable Diseases, Emerging / Q000453:epidemiology / Q000635:transmission / Q000821:virology; D004196:Disease Outbreaks / Q000517:prevention & control; D004197:Disease Reservoirs; D004285:Dogs; D029043:Ebolavirus / Q000302:isolation & purification / Q000502:physiology; D019142:Hemorrhagic Fever, Ebola / Q000453:epidemiology / Q000635:transmission / Q000821:virology; D006801:Humans; D015047:Zoonoses / Q000453:epidemiology