title: Integration of Multi-Modal Biomedical Data to Predict Cancer Grade and Patient Survival.
abstract: The Big Data era in Biomedical research has resulted in large-cohort data repositories such as The Cancer Genome Atlas (TCGA). These repositories routinely contain hundreds of matched patient samples for genomic, proteomic, imaging, and clinical data modalities, enabling holistic and multi-modal integrative analysis of human disease. Using TCGA renal and ovarian cancer data, we conducted a novel investigation of multi-modal data integration by combining histopathological image and RNA-seq data. We compared the performances of two integrative prediction methods: majority vote and stacked generalization. Results indicate that integration of multiple data modalities improves prediction of cancer grade and outcome. Specifically, stacked generalization, a method that integrates multiple data modalities to produce a single prediction result, outperforms both single-data-modality prediction and majority vote. Moreover, stacked generalization reveals the contribution of each data modality (and specific features within each data modality) to the final prediction result and may provide biological insights to explain prediction performance.
authors: Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA 30332 USA.
authors: John H
authors: JH
authors: Phan
authors: Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA 30332 USA.
authors: Ryan
authors: R
authors: Hoffman
authors: Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA 30332 USA.
authors: Sonal
authors: S
authors: Kothari
authors: School of Electrical and Computer Engineering, Georgia Institute of Technology, Atlanta, GA 30332 USA.
authors: Po-Yen
authors: PY
authors: Wu
authors: Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA 30332 USA.
authors: May D
authors: MD
authors: Wang