title: The involvement of central nervous system histamine receptors in psychological stress-induced exacerbation of allergic airway inflammation in mice.
abstract: BACKGROUND
  Psychological stress is one of the major risk factors for asthma exacerbation. Although histamine in the brain acts as an excitatory and inhibitory neurotransmitter associated with psychological stress, the contribution of brain histamine to psychological stress-induced exacerbation of asthma remains unclear. The objective of this study was to investigate the role of histamine receptors in the CNS on stress induced asthma aggravation.
  
  
  METHODS
  We monitored the numbers of inflammatory cells and interleukin (IL)-13 levels in bronchoalveolar lavage fluid, airway responsiveness to inhaled methacholine, mucus secretion in airway epithelial cells, and antigen-specific IgE contents in sera in a murine model of stress-induced asthma treated with epinastine (an H1R antagonist), thioperamide (an H3/4R antagonist), or solvent.
  
  
  RESULTS
  All indicators of stress-induced asthma exacerbation were significantly reduced in stressed mice treated with epinastine compared with those treated with solvent, whereas treatment with thioperamide did not reduce the numbers of inflammatory cells in the stressed mice.
  
  
  CONCLUSIONS
  These results suggest that H1R, but not H3/4R, may be involved in stress-induced asthma exacerbations in the central nervous system.
authors: Department of Pathophysiology, Tohoku Pharmaceutical University, Sendai, Japan. Electronic address: t-miya13@tohoku-mpu.ac.jp.
authors: Tomomitsu
authors: T
authors: Miyasaka
authors: Department of Pathophysiology, Tohoku Pharmaceutical University, Sendai, Japan.
authors: Kaori
authors: K
authors: Okuyama-Dobashi
authors: Department of Pathophysiology, Tohoku Pharmaceutical University, Sendai, Japan.
authors: Chiaki
authors: C
authors: Masuda
authors: Department of Pathophysiology, Tohoku Pharmaceutical University, Sendai, Japan.
authors: Shunya
authors: S
authors: Iwami
authors: Department of Pathophysiology, Tohoku Pharmaceutical University, Sendai, Japan.
authors: Miki
authors: M
authors: Sato
authors: Department of Physiology and Anatomy, Tohoku Pharmaceutical University, Sendai, Japan.
authors: Hirokazu
authors: H
authors: Mizoguchi
authors: Department of Pathophysiology, Tohoku Pharmaceutical University, Sendai, Japan.
authors: Tasuku
authors: T
authors: Kawano
authors: Department of Pathophysiology, Tohoku Pharmaceutical University, Sendai, Japan.
authors: Yuichi
authors: Y
authors: Ohkawara
authors: Department of Physiology and Anatomy, Tohoku Pharmaceutical University, Sendai, Japan.
authors: Shinobu
authors: S
authors: Sakurada
authors: Department of Pathophysiology, Tohoku Pharmaceutical University, Sendai, Japan.
authors: Motoaki
authors: M
authors: Takayanagi
authors: Department of Pathophysiology, Tohoku Pharmaceutical University, Sendai, Japan.
authors: Isao
authors: I
authors: Ohno
mesh_terms: D000818:Animals; D000941:Antigens / Q000276:immunology; D016535:Bronchial Hyperreactivity / Q000209:etiology* / Q000378:metabolism* / Q000473:pathology; D001992:Bronchoalveolar Lavage Fluid / Q000276:immunology; D002490:Central Nervous System / Q000187:drug effects / Q000378:metabolism*; D016207:Cytokines / Q000096:biosynthesis; D004195:Disease Models, Animal; D018450:Disease Progression; D005260:Female; D006633:Histamine Antagonists / Q000494:pharmacology; D007073:Immunoglobulin E / Q000097:blood / Q000276:immunology; D051379:Mice; D009093:Mucus / Q000378:metabolism; D011968:Receptors, Histamine / Q000378:metabolism*; D013315:Stress, Psychological
chemical_list: D000941:Antigens; D016207:Cytokines; D006633:Histamine Antagonists; D011968:Receptors, Histamine; D007073:Immunoglobulin E
keywords: Bronchial asthma; Epinastine; Histamine receptors; Psychological stress; Thioperamide