title: A study of cell proliferation using immunohistological staining: A case report of congenital granular cell epulis.
abstract: An unusual case of a 1-day-old Chinese female neonate with a solid tumor mass in the maxillary anterior ridge of the edentulous jaw is reported. Based on the clinical and histopathological features, the diagnosis was of obstructive congenital granular cell epulis (CGCE) which is an uncommon benign tumor that preferentially develops in female infants. Immunohistochemical analysis of the lesion was performed and the rate of cell proliferation was determined by immunostaining with Ki-67 and PCNA, which showed labeling indexes of 11.1% and 33.3%, respectively. No recurrence was observed in the follow-up.
authors: Department of Oral and Maxillofacial Surgery, Hunan Provincial People's Hospital and The First Affiliated Hospital of Hunan Normal University, Changsha, PR China; Hanwoo DNA Solutions Co., Ltd, Changsha, PR China. Electronic address: michaelbozhang@gmail.com.
authors: Bo
authors: B
authors: Zhang
authors: Hanwoo DNA Solutions Co., Ltd, Changsha, PR China.
authors: Xiaodan
authors: X
authors: Tan
authors: Hanwoo DNA Solutions Co., Ltd, Changsha, PR China.
authors: Kunlun
authors: K
authors: Zhang
authors: Department of Pathology, Hunan Provincial People's Hospital and The First Affiliated Hospital of Hunan Normal University, Changsha, PR China.
authors: Yanchun
authors: Y
authors: Li
authors: Department of Epidemiology and Public Health, University of Maryland School of Medicine, University of Maryland, Baltimore, MD, USA.
authors: Jingjing
authors: J
authors: Chen
authors: Department of Physical Therapy, Baltimore City Community College, Baltimore, MD, USA.
authors: Feng
authors: F
authors: Zhang
mesh_terms: D049109:Cell Proliferation; D005260:Female; D005887:Gingival Neoplasms / Q000151:congenital / Q000378:metabolism* / Q000473:pathology; D016586:Granular Cell Tumor / Q000151:congenital / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D007231:Infant, Newborn; D019394:Ki-67 Antigen / Q000378:metabolism; D018809:Proliferating Cell Nuclear Antigen / Q000378:metabolism; D013194:Staining and Labeling
chemical_list: D019394:Ki-67 Antigen; D018809:Proliferating Cell Nuclear Antigen
keywords: Congenital granular cell epulis; Infant; Ki-67; Labeling indexes; PCNA