title: Localized mucosal leishmaniasis caused by Leishmania infantum mimicking cancer in the rhinolaryngeal region.
abstract: The clinical, microbiological, and histopathological findings of six patients with mucosal leishmaniasis are reported. Five of these patients were Spanish with no history of travel abroad, while the other was from Bolivia but had lived in Spain for more than 5 years. Two patients had no underlying disease, while the other four had several other medical conditions. Lesions were located in the nose in three patients and in the larynx in the other three. Symptoms included difficulty in swallowing, nasal obstruction, dysphonia, and polypoid lesions mimicking cancer. The diagnosis was based on the identification of parasites, or on PCR assay or culture. Five patients were treated with liposomal amphotericin B and the other with antimonial compounds.
authors: Microbiology Department, Hospital Virgen de las Nieves, Avda Fuerzas Armadas, 2, 18014 Granada, Spain. Electronic address: fernando.cobo.sspa@juntadeandalucia.es.
authors: Fernando
authors: F
authors: Cobo
authors: Microbiology Department, Hospital Virgen de las Nieves, Avda Fuerzas Armadas, 2, 18014 Granada, Spain.
authors: Javier
authors: J
authors: Rodríguez-Granger
authors: Microbiology Department, Hospital Virgen de las Nieves, Avda Fuerzas Armadas, 2, 18014 Granada, Spain.
authors: Cristina
authors: C
authors: Gómez-Camarasa
authors: Microbiology Department, Hospital Virgen de las Nieves, Avda Fuerzas Armadas, 2, 18014 Granada, Spain.
authors: Antonio
authors: A
authors: Sampedro
authors: Internal Medicine Department, Hospital Virgen de las Nieves, Granada, Spain.
authors: Luis
authors: L
authors: Aliaga-Martínez
authors: Microbiology Department, Hospital Virgen de las Nieves, Avda Fuerzas Armadas, 2, 18014 Granada, Spain.
authors: José María
authors: JM
authors: Navarro
authors: Microbiology Department, School of Medicine, University of Granada, Granada, Spain.
authors: José Gutiérrez
authors: JG
authors: Fernández
mesh_terms: D000328:Adult; D000368:Aged; D000666:Amphotericin B / Q000627:therapeutic use; D000818:Animals; D005260:Female; D006801:Humans; D007830:Larynx / Q000469:parasitology*; D018314:Leishmania infantum / Q000235:genetics / Q000302:isolation & purification* / Q000502:physiology; D007897:Leishmaniasis, Mucocutaneous / Q000188:drug therapy / Q000469:parasitology* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000469:parasitology / Q000473:pathology; D009666:Nose / Q000469:parasitology; D016133:Polymerase Chain Reaction; D013030:Spain
chemical_list: D000666:Amphotericin B
keywords: Cancer; Culture; Giemsa; Leishmania infantum; Mucosal leishmaniasis