title: Clinical Outcomes of Intracranial Nonvestibular Schwannomas Treated with LinacBased Stereotactic Radiosurgery and Radiotherapy.
abstract: BACKGROUND
  Intracranial nonvestibular schwannomas arising from various cranial nerves excluding CN VIII are uncommon. Recently, stereotactic radiosurgery (SRS) and fractionated stereotactic radiotherapy (SRT) have been widely reported as effective treatment modalities for nonvestibular schwannomas. The purpose of this study was to study the long term clinical outcome for nonvestibular schwannomas treated with both XKnife and CyberKnife (CK) radiosurgery at one institution.
  
  
  METHODS
  From 2004 to 2013, fiftytwo nonvestibular schwannoma patients were included in this study, 33 patients (63%) were treated with CK, and 19 (37%) were treated with XKnife. The majority of the tumors were jugular foramen schwannomas (38%) and trigeminal schwannomas (27%). HSRT was given for 45 patients (86%), whereas CSRT was for 6 (12%) and SRS for 1 (2%).
  
  
  RESULTS
  The median pretreatment volume was 9.4 cm3 (range, 0.5752 cm3). With the median follow up time of 36 months (range, 3135), the 3 and 5 year progression free survival was 94 % and 88%, respectively. Tumor size was decreased in 13 (25%), stable in 29 (56%), and increased in 10 (19%). Among the latter, 3 (30%) required additional treatment because of neurologic deterioration. No patient was found to develop any new cranial nerve deficit after SRS/SRT.
  
  
  CONCLUSIONS
  These data confirmed that SRS/ SRT provide high tumor control rates with low complications. Large volume tumors and cystic expansion after radiation should be carefully followed up with neurological examination and MRI, because it may frequently cause neurological deterioration requiring further surgery.
authors: Radiation and Oncology Unit, Department of Radiology, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand Email : putipun.pua@mahidol.ac.th.
authors: Putipun
authors: P
authors: Puataweepong
authors: Mantana
authors: M
authors: Dhanachai
authors: Ake
authors: A
authors: Hansasuta
authors: Kriangsak
authors: K
authors: Saetia
authors: Somjai
authors: S
authors: Dangprasert
authors: Chomporn
authors: C
authors: Sitathanee
authors: Pornpan
authors: P
authors: Yongvithisatid
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003390:Cranial Nerve Neoplasms / Q000473:pathology / Q000601:surgery*; D019583:Dose Fractionation, Radiation; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000473:pathology / Q000601:surgery*; D009367:Neoplasm Staging; D009442:Neurilemmoma / Q000473:pathology / Q000601:surgery*; D011379:Prognosis; D016634:Radiosurgery / Q000401:mortality*; D012074:Remission Induction; D015996:Survival Rate; D055815:Young Adult