title: Factors Associated With Disease Recurrence in Breast Cancer Patients With Negative Sentinel Lymph Node Biopsy.
abstract: The objective of our study was to assess recurrence after negative sentinel lymph node biopsy (SLNB) and to determine the risk factors related to local and distant recurrence in this group of patients.
  
  
  
  We conducted a prospective observational study from 2006 to 2011. It included 607 patients with early-stage breast cancer and negative SLNB with a 5-year follow-up period.
  
  
  
  The disease-free survival rate was 98.5% and 96.5% at 2 and 5 years, respectively. Multivariate analysis identified the following prognostic factors for disease recurrence: tumor necrosis (hazard ratio [HR], 4.89; 95% confidence interval [CI], 1.61-14.89; P = .005), lymphovascular invasion (HR, 3.46; 95% CI, 1.14-10.55; P = .029), T2 tumor size (HR, 4.35; 95% CI, 1.40-13.52; P = .011), and moderate to severe lymphoplasmacytic stromal infiltration (HR, 3.06; 95% CI, 1.18-7.96; P = .022).
  
  
  
  Recurrence in patients with negative SLNB was satisfactorily low. Nevertheless, determining the prognostic factors related to a greater recurrence rate could help identify high-risk patients and influence systemic adjuvant therapy.
authors: Department of Surgery, University Hospital Reina Sofía, Córdoba, Spain. Electronic address: helenanr1@hotmail.com.
authors: Elena
authors: E
authors: Navarro-Rodríguez
authors: Department of Surgery, University Hospital Reina Sofía, Córdoba, Spain.
authors: Nélida
authors: N
authors: Díaz-Jiménez
authors: Department of Surgery, University Hospital Reina Sofía, Córdoba, Spain.
authors: Juan
authors: J
authors: Ruiz-Rabelo
authors: Department of Surgery, University Hospital Reina Sofía, Córdoba, Spain.
authors: Irene
authors: I
authors: Gómez-Luque
authors: Department of Surgery, University Hospital Reina Sofía, Córdoba, Spain.
authors: Guillermo
authors: G
authors: Bascuñana-Estudillo
authors: Department of Surgery, University Hospital Reina Sofía, Córdoba, Spain.
authors: Pilar
authors: P
authors: Rioja-Torres
authors: Department of Surgery, University Hospital Reina Sofía, Córdoba, Spain.
authors: Manuela
authors: M
authors: Torres-Lorite
authors: Department of Surgery, University Hospital Reina Sofía, Córdoba, Spain.
authors: Rubén
authors: R
authors: Ciria-Bru
authors: Department of Radiodiagnosis, University Hospital Reina Sofía, Córdoba, Spain.
authors: Marina
authors: M
authors: Álvarez-Benito
authors: Department of Surgery, University Hospital Reina Sofía, Córdoba, Spain.
authors: Javier
authors: J
authors: Briceño-Delgado
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001365:Axilla; D001943:Breast Neoplasms / Q000453:epidemiology* / Q000473:pathology* / Q000628:therapy; D003131:Combined Modality Therapy; D018572:Disease-Free Survival; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008207:Lymphatic Metastasis; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000453:epidemiology* / Q000473:pathology* / Q000628:therapy; D009367:Neoplasm Staging; D011379:Prognosis; D011446:Prospective Studies; D012307:Risk Factors; D000071036:Sentinel Lymph Node / Q000473:pathology; D021701:Sentinel Lymph Node Biopsy; D015996:Survival Rate; D055815:Young Adult
keywords: Breast cancer; Disease recurrence; Metastases; Negative lymph nodes; Sentinel node