title: Microbiota and chronic inflammatory arthritis: an interwoven link.
abstract: Only recently, the scientific community gained insights on the importance of the intestinal resident flora for the host's health and disease. Gut microbiota in fact plays a crucial role in modulating innate and acquired immune responses and thus interferes with the fragile balance inflammation versus tolerance.
  
  
  
  Correlations between gut bacteria composition and the severity of inflammation have been studied in inflammatory bowel diseases. More recently similar alterations in the gut microbiota have been reported in patients with spondyloarthritis, whereas in rheumatoid arthritis an accumulating body of evidence evokes a pathogenic role for the altered oral microbiota in disease development and course. In the context of dysbiosis it is also important to remember that different environmental factors like stress, smoke and dietary components can induce strong bacterial changes and consequent exposure of the intestinal epithelium to a variety of different metabolites, many of which have an unknown function. In this perspective, and in complex disorders like autoimmune diseases, not only the genetic makeup, sex and immunologic context of the individual but also the structure of his microbial community should be taken into account.
  
  
  
  Here we provide a review of the role of the microbiota in the onset, severity and progression of chronic inflammatory arthritis as well as its impact on the therapeutic management of these patients. Furthermore we point-out the complex interwoven link between gut-joint-brain and immune system by reviewing the most recent data on the literature on the importance of environmental factors such as diet, smoke and stress.
authors: Department of Clinical and Molecular Sciences, II School of Medicine, S. Andrea University Hospital, "Sapienza" University of Rome, Rome, Italy. andrea.picchiantidiamanti@uniroma1.it.|Department of Clinical and Molecular Medicine, School of Medicine and Psychology, S. Andrea University Hospital, "Sapienza" University, Via di Grottarossa 1039, 00189, Rome, Italy. andrea.picchiantidiamanti@uniroma1.it.
authors: Andrea Picchianti
authors: 0000-0002-8552-4641
authors: AP
authors: Diamanti
authors: Consultant in Immunology, Rome, Italy.
authors: M
authors: M
authors: Manuela Rosado
authors: Department of Clinical and Molecular Sciences, II School of Medicine, S. Andrea University Hospital, "Sapienza" University of Rome, Rome, Italy.
authors: Bruno
authors: B
authors: Laganà
authors: Department of Clinical and Molecular Sciences, II School of Medicine, S. Andrea University Hospital, "Sapienza" University of Rome, Rome, Italy.
authors: Raffaele
authors: R
authors: D'Amelio
mesh_terms: D000818:Animals; D001168:Arthritis / Q000150:complications* / Q000382:microbiology* / Q000628:therapy; D002908:Chronic Disease; D004777:Environment; D006801:Humans; D007249:Inflammation / Q000150:complications* / Q000473:pathology*; D064307:Microbiota
keywords: Chronic inflammatory arthritis; Diet; Immunosuppressant; Microbiota; Probiotic; Smoke; Stress