title: Determining the Optimal Carbapenem MIC That Distinguishes Carbapenemase-Producing and Non-Carbapenemase-Producing Carbapenem-Resistant Enterobacteriaceae.
abstract: Carbapenemase-producing (CP) Enterobacteriaceae are largely responsible for the rapid spread of carbapenem-resistant Enterobacteriaceae (CRE). Distinguishing CP-CRE from non-CP-CRE has important infection control implications. In a cohort of 198 CRE isolates, for isolates that remained susceptible or intermediate to some carbapenem antibiotics, an ertapenem MIC of 0.5 μg/ml and meropenem, imipenem, and doripenem MICs of 2 μg/ml were best able to distinguish CP-CRE from non-CP-CRE isolates.
authors: Division of Pediatric Infectious Disease, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA ptamma1@jhmi.edu.
authors: Pranita D
authors: PD
authors: Tamma
authors: Department of Health Policy and Management, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.
authors: Yanjie
authors: Y
authors: Huang
authors: Division of Medical Microbiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
authors: Belita N A
authors: BN
authors: Opene
authors: Division of Medical Microbiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
authors: Patricia J
authors: PJ
authors: Simner
mesh_terms: D001426:Bacterial Proteins / Q000378:metabolism*; D015780:Carbapenems / Q000494:pharmacology*; D024881:Drug Resistance, Bacterial / Q000187:drug effects; D004755:Enterobacteriaceae / Q000187:drug effects* / Q000302:isolation & purification / Q000378:metabolism; D006801:Humans; D008826:Microbial Sensitivity Tests / Q000379:methods*; D012372:ROC Curve; D001618:beta-Lactamases / Q000378:metabolism*
chemical_list: D001426:Bacterial Proteins; D015780:Carbapenems; D001618:beta-Lactamases; C063912:carbapenemase