title: Reconstruction of Internal Doses for the Alpha-Risk Case-Control Study of Lung Cancer and Leukaemia Among European Nuclear Workers.
abstract: The Alpha-Risk study required the reconstruction of doses to lung and red bone marrow for lung cancer and leukaemia cases and their matched controls from cohorts of nuclear workers in the UK, France and Belgium. The dosimetrists and epidemiologists agreed requirements regarding the bioassay data, biokinetic and dosimetric models and dose assessment software to be used and doses to be reported. The best values to use for uncertainties on the monitoring data, setting of exposure regimes and characteristics of the exposure material, including lung solubility, were the responsibility of the dosimetrist responsible for each cohort. Among 1721 subjects, the median absorbed dose to the lung from alpha radiations was 2.1 mGy, with a maximum dose of 316 mGy. The lung doses calculated reflect the higher levels of exposure seen among workers in the early years of the nuclear industry compared to today.
authors: AWE plc, Aldermaston, Reading RG7 4PR, UK.
authors: Derek
authors: D
authors: Bingham
authors: CEA, Fontenay-aux-Roses92265, France.
authors: Philippe
authors: P
authors: Bérard
authors: PHE, CRCE, Chilton, Didcot, OxfordshireOX110RQ, UK.
authors: Alan
authors: A
authors: Birchall
authors: Nuvia Limited, Harwell, Didcot, OxfordshireOX11 0RL, UK.
authors: Richard
authors: R
authors: Bull
authors: CREAL, PRBB, Doctor Aiguader, 88, 08003 Barcelona, Spain.
authors: Elisabeth
authors: E
authors: Cardis
authors: IRSN, Fontenay-aux-Roses92260, France.
authors: Cécile
authors: C
authors: Challeton-de Vathaire
authors: CREAL, PRBB, Doctor Aiguader, 88, 08003 Barcelona, Spain.
authors: James
authors: J
authors: Grellier
authors: SCK·CEN, Boeretang 200 B-2400 Mol, Belgium.
authors: Christian
authors: C
authors: Hurtgen
authors: PHE, CRCE, Chilton, Didcot, OxfordshireOX110RQ, UK.
authors: Matthew
authors: M
authors: Puncher
authors: PHE, CRCE, Chilton, Didcot, OxfordshireOX110RQ, UK.
authors: Anthony
authors: A
authors: Riddell
authors: IARC, 150 Cours A. Thomas, 69372 Lyon Cedex 08, France.
authors: Isabelle
authors: I
authors: Thierry-Chef
mesh_terms: D001530:Belgium; D016022:Case-Control Studies; D005602:France; D006801:Humans; D007938:Leukemia / Q000453:epidemiology*; D008175:Lung Neoplasms / Q000453:epidemiology*; D016273:Occupational Exposure; D011829:Radiation Dosage; D000069079:Radiation Exposure