title: Tirucallane-type triterpenoids from the fruits of Phellodendron chinense Schneid and their cytotoxic activities.
abstract: Eleven triterpenoids were isolated from the fruits of Phellodendron chinense Schneid, and their structures were determined by spectroscopic analysis. The results show that four new tirucallane-type triterpenoids 1, 2, 5, and 6 and seven known compounds 3, 4, 7, 8, 9, 10, and 11 were isolated. Structurally, compound 6 was uncommon; it has a chlorine atom instead of a methyl group at the C-20 position. The cytotoxicities of the compounds was evaluated against the in vitro proliferation of four human tumor cell lines HEL, K562, MDA, and PC3 using adriamycin as the positive control. Compound 1 showed a similar cytotoxicity as the positive control; compounds 3 and 10 showed moderate cytotoxicities compared to the control (P<0.05). This indicates that these compounds have great potential for the development of new antitumor drugs.
authors: An Shun City People's Hospital, Anshun, People's Republic of China.
authors: Chen
authors: C
authors: Yan
authors: An Shun City People's Hospital, Anshun, People's Republic of China.
authors: Yun-Dong
authors: YD
authors: Zhang
authors: Key Laboratory of Chemistry for Natural Product of Guizhou Province, Chinese Academy of Science, Guiyang, People's Republic of China.
authors: Xing-Hui
authors: XH
authors: Wang
authors: Key Laboratory of Chemistry for Natural Product of Guizhou Province, Chinese Academy of Science, Guiyang, People's Republic of China.
authors: Shun-Dong
authors: SD
authors: Geng
authors: An Shun City People's Hospital, Anshun, People's Republic of China.
authors: Tian-Yuan
authors: TY
authors: Wang
authors: An Shun City People's Hospital, Anshun, People's Republic of China.
authors: Mao
authors: M
authors: Sun
authors: An Shun City People's Hospital, Anshun, People's Republic of China.
authors: Wei
authors: W
authors: Liang
authors: An Shun City People's Hospital, Anshun, People's Republic of China.
authors: Wei-Qing
authors: WQ
authors: Zhang
authors: Beijing Chao-Yang Hospital, Capital Medical University, Beijing, People's Republic of China. Electronic address: zxd581@263.net.
authors: Xiao-Dong
authors: XD
authors: Zhang
authors: Key Laboratory of Chemistry for Natural Product of Guizhou Province, Chinese Academy of Science, Guiyang, People's Republic of China. Electronic address: luohengzz@sina.com.
authors: Heng
authors: H
authors: Luo
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000302:isolation & purification; D045744:Cell Line, Tumor; D005638:Fruit / Q000737:chemistry*; D006801:Humans; D015394:Molecular Structure; D032102:Phellodendron / Q000737:chemistry*; D010936:Plant Extracts / Q000737:chemistry; D014315:Triterpenes / Q000737:chemistry* / Q000302:isolation & purification
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D010936:Plant Extracts; D014315:Triterpenes; C514393:tirucallane
keywords: Antitumor; Cytotoxicity; Phellodendron chinense Schneid; Tirucallane-type triterpenoids