title: Serum levels of copeptin are associated with type 2 diabetes and diabetic complications in Chinese population.
abstract: The aim of this study was to investigate copeptin levels in serum, and assess their associations with type 2 diabetes (T2DM) and diabetic complications.
  
  
  
  In this post hoc analysis, serum levels of copeptin were tested in 306 patients with T2DM. Clinical information including diabetic retinopathy (DR) and diabetic nephropathy (DN) were collected. The relation of serum copeptin with DR and DN were investigated with the use of logistic regression models according to equal quartiles of the distributions of serum copeptin.
  
  
  
  We found that serum copeptin levels were significantly higher in diabetes as compared to normal controls [9.4(IQR, 7.4-12.5) pmol/L vs. 4.1(IQR, 2.5-6.2) pmol/L; P<0.0001]. In multivariate analysis, there was an increased risk of T2DM associated with copeptin levels (OR 1.312, 95% CI: 1.204-1.403; P<0.0001) after adjusting for possible confounders. After adjustment for possible confounders, serum copeptin levels were positively associated with the DR (odds ratio [OR], 1.117; 95% confidence interval [CI], 1.072-1.241; P<0.001) and DN (OR, 1.259; 95% CI, 1.198-1.323; P<0.001). Compared with the first quartile of serum copeptin levels, the ORs for DR and DN were as follows: second quartile, 1.19 (95% CI, 0.94-1.51, P=0.12) and 1.37 (95% CI, 0.78-2.37, P=0.28); third quartile, 1.61 (95% CI, 1.18-2.43, P=0.005) and 2.12 (95% CI, 1.32-3.27, P=0.003); fourth quartile, 2.83 (95% CI, 2.04-4.93; P<0.001) and 3.48 (95% CI, 1.77-7.03; P<0.001), respectively.
  
  
  
  Using a post-hoc analysis our data show that elevated serum levels of copeptin are associated with type 2 diabetes and diabetic complications in Chinese population, suggesting a potential role of the AVP system (copeptin) in the pathophysiology of diabetes.
authors: Department of Nephrology, the First Hospital of Jiaxing, Jiaxing 314001, Zhejiang Province, PR China. Electronic address: Zfxywh@163.com.
authors: Fu-Xiang
authors: FX
authors: Zhu
authors: Department of Nephrology, the First Hospital of Jiaxing, Jiaxing 314001, Zhejiang Province, PR China.
authors: Heng-Lan
authors: HL
authors: Wu
authors: Department of Endocrinology, the Affiliated Beijing Rehabilitation Hospital of Capital Medical University, Beijing 100144, PR China.
authors: Kai-Sheng
authors: KS
authors: Tu
authors: Department of Nephrology, the First Hospital of Jiaxing, Jiaxing 314001, Zhejiang Province, PR China.
authors: Jian-Xiang
authors: JX
authors: Chen
authors: Department of Nephrology, the First Hospital of Jiaxing, Jiaxing 314001, Zhejiang Province, PR China.
authors: Min
authors: M
authors: Zhang
authors: Department of Nephrology, the First Hospital of Jiaxing, Jiaxing 314001, Zhejiang Province, PR China.
authors: Chao
authors: C
authors: Shi
mesh_terms: D000368:Aged; D044466:Asian People; D016022:Case-Control Studies; D002681:China; D015331:Cohort Studies; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000150:complications; D003928:Diabetic Nephropathies / Q000097:blood*; D003930:Diabetic Retinopathy / Q000097:blood*; D005260:Female; D006020:Glycopeptides / Q000097:blood*; D006801:Humans; D008297:Male; D008875:Middle Aged
chemical_list: D006020:Glycopeptides; C048197:copeptins
keywords: Copeptin; Diabetic nephropathy; Diabetic retinopathy; Risk; Type 2 diabetes mellitus