title: In Vivo Corneal Biomechanical Properties with Corneal Visualization Scheimpflug Technology in Chinese Population.
abstract: Purpose. To determine the repeatability of recalculated corneal visualization Scheimpflug technology (CorVis ST) parameters and to study the variation of biomechanical properties and their association with demographic and ocular characteristics. Methods. A total of 783 healthy subjects were included in this study. Comprehensive ophthalmological examinations were conducted. The repeatability of the recalculated biomechanical parameters with 90 subjects was assessed by the coefficient of variation (CV) and intraclass correlation coefficient (ICC). Univariate and multivariate linear regression models were used to identify demographic and ocular factors. Results. The repeatability of the central corneal thickness (CCT), deformation amplitude (DA), and first/second applanation time (A1/A2-time) exhibited excellent repeatability (CV% ≤ 3.312% and ICC ≥ 0.929 for all measurements). The velocity in/out (V in/out), highest concavity- (HC-) radius, peak distance (PD), and DA showed a normal distribution. Univariate linear regression showed a statistically significant correlation between V in, V out, DA, PD, and HC-radius and IOP, CCT, and corneal volume, respectively. Multivariate analysis showed that IOP and CCT were negatively correlated with V in, DA, and PD, while there was a positive correlation between V out and HC-radius. Conclusion. The ICCs of the recalculated parameters, CCT, DA, A1-time, and A2-time, exhibited excellent repeatability. IOP, CCT, and corneal volume significantly influenced the biomechanical properties of the eye.
authors: Department of Ophthalmology, Chinese PLA General Hospital, Beijing 100853, China.
authors: Ying
authors: Y
authors: Wu
authors: Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology & Visual Sciences Key Laboratory, Beijing 100730, China.
authors: Lei
authors: 0000-0002-7216-5352
authors: L
authors: Tian
authors: Department of Ophthalmology, Chinese PLA General Hospital, Beijing 100853, China.
authors: Yi-Fei
authors: 0000-0002-1135-239X
authors: YF
authors: Huang
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D044466:Asian People / Q000706:statistics & numerical data*; D001696:Biomechanical Phenomena; D003315:Cornea / Q000000981:diagnostic imaging* / Q000502:physiology; D003430:Cross-Sectional Studies; D003941:Diagnostic Techniques, Ophthalmological / Q000592:standards*; D005260:Female; D006801:Humans; D007429:Intraocular Pressure; D008297:Male; D008875:Middle Aged; D012016:Reference Values; D015203:Reproducibility of Results; D055815:Young Adult