title: Histopathological and ophthalmoscopic evaluation of apocynin on experimental proliferative vitreoretinopathy in rabbit eyes.
abstract: The aim of the current study was to evaluate the effect of apocynin (APO) on the development of proliferative vitreoretinopathy (PVR). New Zealand-type male rabbits were randomly grouped into three as follows: (1) Sham group rabbits which were applied intraperitoneal (i.p.) vehicle without PVR; (2) PVR group rabbits where PVR was created and an i.p. vehicle was administered for 21 successive days; (3) PVR + APO group rabbits where PVR was created and i.p. APO was administered for 21 successive days. Fundus examination was conducted with an indirect ophthalmoscope before starting the experiments and at each visit afterwards. At the end of the work, the rabbits were sacrificed under high-dose anesthesia and then eye tissues were taken for histopathological analyses. In the PVR + APO group, histopathologic and ophthalmoscopic examination revealed significant decrease in PVR formation. As the result, it has been observed that APO at least partially inhibits PVR formation.
authors: Department of Ophthalmology, Medical Faculty, Giresun University, Giresun, Turkey. dratabeyozer@yandex.com.
authors: Murat Atabey
authors: MA
authors: Ozer
authors: Department of Ophthalmolohy, Medical Faculty, Inonu University, Malatya, Turkey.
authors: Nihat
authors: N
authors: Polat
authors: Department of Ophthalmology, Medical Faculty, Giresun University, Giresun, Turkey.
authors: Serkan
authors: S
authors: Ozen
authors: Department of Ophthalmolohy, Medical Faculty, Kirikkale University, Kirikkale, Turkey.
authors: Tevfik
authors: T
authors: Ogurel
authors: Department of Pharmacology, Medical Faculty, Inonu University, Malatya, Turkey.
authors: Hakan
authors: H
authors: Parlakpinar
authors: Department of Histology and Embryology, Medical Faculty, Inonu University, Malatya, Turkey.
authors: Nigar
authors: N
authors: Vardi
mesh_terms: D000098:Acetophenones / Q000494:pharmacology*; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology; D004195:Disease Models, Animal; D008297:Male; D009887:Ophthalmoscopy / Q000379:methods*; D011817:Rabbits; D012160:Retina / Q000187:drug effects / Q000473:pathology*; D016896:Treatment Outcome; D018630:Vitreoretinopathy, Proliferative / Q000175:diagnosis / Q000188:drug therapy*; D014822:Vitreous Body / Q000187:drug effects / Q000473:pathology*
chemical_list: D000098:Acetophenones; D000894:Anti-Inflammatory Agents, Non-Steroidal; C056165:acetovanillone
keywords: Apocynin; Eye; Proliferative vitreoretinopathy; Rabbit