title: Mitochondrial protein import: An unexpected disulfide bond.
abstract: Most mitochondrial proteins are imported through the TIM23 translocation channel, the structure and molecular nature of which are still unclear. In this issue, Ramesh et al. (2016. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201602074) show that the TIM23 subunit Tim17 contains a disulfide bond that is crucial for protein translocation and channel gating.
authors: Biomedical Center Munich - Physiological Chemistry, LMU Munich, 82152 Martinsried, Germany dejana.mokranjac@med.lmu.de.
authors: Dejana
authors: D
authors: Mokranjac
mesh_terms: D004220:Disulfides / Q000378:metabolism*; D008928:Mitochondria / Q000378:metabolism*; D051336:Mitochondrial Membranes / Q000378:metabolism; D024101:Mitochondrial Proteins / Q000378:metabolism*; D010084:Oxidation-Reduction; D021381:Protein Transport; D012441:Saccharomyces cerevisiae / Q000378:metabolism; D029701:Saccharomyces cerevisiae Proteins / Q000378:metabolism
chemical_list: D004220:Disulfides; D024101:Mitochondrial Proteins; D029701:Saccharomyces cerevisiae Proteins