title: Circulating MicroRNAs as Potential Molecular Biomarkers in Pathophysiological Evolution of Pregnancy.
abstract: MicroRNAs represent nonprotein coding small RNA molecules that are very stable to degradation and responsible for gene silencing in most eukaryotic cells. Increased evidence has been accumulating over the years about their potential value as biomarkers for several diseases. MicroRNAs were predicted to be involved in nearly all biological processes from development to oncogenesis. In this review, we address the importance of circulating microRNAs in different conditions associated with pregnancy starting with the implantation period to preeclampsia and we shortly describe the correlation between placental circulating miRNAs and pregnancy status. We also discuss the importance of microRNAs in recurrent abortion and ectopic pregnancy.
authors: Division of Cellular and Molecular Biology and Histology, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, Romania; Victor Babeș National Institute of Pathology, 050096 Bucharest, Romania.
authors: Dragos
authors: 0000-0003-3214-030X
authors: D
authors: Cretoiu
authors: Department of Cardiology, Tongji Hospital, Tongji University School of Medicine, Shanghai 200065, China.
authors: Jiahong
authors: J
authors: Xu
authors: Regeneration and Ageing Lab, Experimental Center of Life Sciences, School of Life Science, Shanghai University, Shanghai 200444, China.
authors: Junjie
authors: J
authors: Xiao
authors: Department of Obstetrics and Gynecology, Polizu Clinical Hospital, Carol Davila University of Medicine and Pharmacy, 011062 Bucharest, Romania; Alessandrescu-Rusescu National Institute of Mother and Child Health, 020395 Bucharest, Romania.
authors: Nicolae
authors: N
authors: Suciu
authors: Division of Cellular and Molecular Biology and Histology, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, Romania; Victor Babeș National Institute of Pathology, 050096 Bucharest, Romania.
authors: Sanda Maria
authors: 0000-0003-2575-4880
authors: SM
authors: Cretoiu
mesh_terms: D015415:Biomarkers / Q000097:blood; D004461:Eclampsia / Q000097:blood* / Q000209:etiology; D010064:Embryo Implantation; D005260:Female; D006801:Humans; D035683:MicroRNAs / Q000097:blood*; D011225:Pre-Eclampsia / Q000097:blood* / Q000209:etiology; D011247:Pregnancy; D011271:Pregnancy, Ectopic / Q000097:blood* / Q000209:etiology
chemical_list: D015415:Biomarkers; D035683:MicroRNAs