title: Transcranial Doppler as a Predictor of Ischemic Events in Carotid Artery Dissection.
abstract: We aim to evaluate clinical features and transcranial Doppler (TCD) elements, as predictors of the development of ischemic events (IEs) in patients suffering from spontaneous carotid arterial dissection without stroke (CCADW).
  
  
  
  Consecutive patients with CCADW, seen in Clínica Alemana de Santiago between April 2004 and January 2015, were evaluated clinically, and with TCD, microembolic signals (MES) monitoring and breath hold Index (BHI) test were performed.
  
  
  
  Forty-one patients with 45 CCADW were included. Mean age 41.9 years, 31 male, and 12 (29.1%) patients present with multiple CCADW. At the moment of TCD evaluation, 17 (41.4%) patients were being treated with antiplatelets and the rest under Heparin. TCD monitoring lasted in average 53.3 minutes and demonstrated at the moment of evaluation, MES in four carotid arteries (11.1%) of 3 patients and 13 (28.8%) abnormal BHI in 11 patients. Six IEs occurred in 3 patients, 3 strokes, and 3 transient ischemic attacks. In the univariate analysis correlating IE with clinical and ultrasonographic findings, the degree of carotid stenosis, the presence of multiple CAD, and the presence of MES plus abnormalities of BHI were significantly associated with the risk of an IE. Multivariable analysis showed that only the presence of MES plus abnormal BHI were significant (P < .001). MES and abnormal BHI were present in the 3 patients and in four arterial territories that had IE.
  
  
  
  TCD can identify a subgroup of patients with CCADW who are at high risk of IE.
authors: Vascular Neurology Program, Neurology service, Department of Medicine, Clínica Alemana de Santiago, Facultad de Medicina Clínica Alemana, Universidad del Desarrollo, Santiago, Chile.
authors: Alejandro M
authors: AM
authors: Brunser
authors: Vascular Neurology Program, Neurology service, Department of Medicine, Clínica Alemana de Santiago, Facultad de Medicina Clínica Alemana, Universidad del Desarrollo, Santiago, Chile.
authors: Pablo M
authors: PM
authors: Lavados
authors: Vascular Neurology Program, Neurology service, Department of Medicine, Clínica Alemana de Santiago, Facultad de Medicina Clínica Alemana, Universidad del Desarrollo, Santiago, Chile.
authors: Arnold
authors: A
authors: Hoppe
authors: Vascular Neurology Program, Neurology service, Department of Medicine, Clínica Alemana de Santiago, Facultad de Medicina Clínica Alemana, Universidad del Desarrollo, Santiago, Chile.
authors: Paula
authors: P
authors: Muñoz-Venturelli
authors: Vascular Neurology Program, Neurology service, Department of Medicine, Clínica Alemana de Santiago, Facultad de Medicina Clínica Alemana, Universidad del Desarrollo, Santiago, Chile.
authors: Emi
authors: E
authors: Sujima
authors: Vascular Neurology Program, Neurology service, Department of Medicine, Clínica Alemana de Santiago, Facultad de Medicina Clínica Alemana, Universidad del Desarrollo, Santiago, Chile.
authors: Javiera
authors: J
authors: López
authors: Vascular Neurology Program, Neurology service, Department of Medicine, Clínica Alemana de Santiago, Facultad de Medicina Clínica Alemana, Universidad del Desarrollo, Santiago, Chile.
authors: Eloy
authors: E
authors: Mansilla
authors: Vascular Neurology Program, Neurology service, Department of Medicine, Clínica Alemana de Santiago, Facultad de Medicina Clínica Alemana, Universidad del Desarrollo, Santiago, Chile.
authors: Daniel
authors: D
authors: Cárcamo
authors: Vascular Neurology Program, Neurology service, Department of Medicine, Clínica Alemana de Santiago, Facultad de Medicina Clínica Alemana, Universidad del Desarrollo, Santiago, Chile.
authors: Violeta
authors: V
authors: Díaz
mesh_terms: D000293:Adolescent; D000328:Adult; D000784:Aortic Dissection / Q000000981:diagnostic imaging* / Q000503:physiopathology; D001808:Blood Vessels / Q000503:physiopathology; D002545:Brain Ischemia / Q000000981:diagnostic imaging* / Q000503:physiopathology; D002340:Carotid Artery Diseases / Q000000981:diagnostic imaging* / Q000503:physiopathology; D005260:Female; D006801:Humans; D020766:Intracranial Embolism / Q000000981:diagnostic imaging / Q000503:physiopathology; D002546:Ischemic Attack, Transient / Q000000981:diagnostic imaging / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D017585:Ultrasonography, Doppler, Transcranial; D055815:Young Adult
keywords: Ultrasound; cervical artery dissection; stroke; transcranial Doppler ultrasound