title: Brown Adipose Reporting Criteria in Imaging STudies (BARCIST 1.0): Recommendations for Standardized FDG-PET/CT Experiments in Humans.
abstract: Human brown adipose tissue (BAT) presence, metabolic activity, and estimated mass are typically measured by imaging [18F]fluorodeoxyglucose (FDG) uptake in response to cold exposure in regions of the body expected to contain BAT, using positron emission tomography combined with X-ray computed tomography (FDG-PET/CT). Efforts to describe the epidemiology and biology of human BAT are hampered by diverse experimental practices, making it difficult to directly compare results among laboratories. An expert panel was assembled by the National Institute of Diabetes and Digestive and Kidney Diseases on November 4, 2014 to discuss minimal requirements for conducting FDG-PET/CT experiments of human BAT, data analysis, and publication of results. This resulted in Brown Adipose Reporting Criteria in Imaging STudies (BARCIST 1.0). Since there are no fully validated best practices at this time, panel recommendations are meant to enhance comparability across experiments, but not to constrain experimental design or the questions that can be asked.
authors: National Institutes of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA. Electronic address: kong.chen@nih.gov.
authors: Kong Y
authors: KY
authors: Chen
authors: National Institutes of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA. Electronic address: aaron.cypess@nih.gov.
authors: Aaron M
authors: AM
authors: Cypess
authors: National Institutes of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA. Electronic address: maren.laughlin@nih.gov.
authors: Maren R
authors: MR
authors: Laughlin
authors: National Institutes of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
authors: Carol R
authors: CR
authors: Haft
authors: Phoenix Children's Hospital, Phoenix, AZ 85016, USA.
authors: Houchun Harry
authors: HH
authors: Hu
authors: Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
authors: Miriam A
authors: MA
authors: Bredella
authors: Göteborg University, 405 30 Göteborg, Sweden.
authors: Sven
authors: S
authors: Enerbäck
authors: University of Washington, Seattle, WA 98105, USA.
authors: Paul E
authors: PE
authors: Kinahan
authors: Maastricht University, 6211 LK Maastricht, Netherlands.
authors: Wouter van Marken
authors: Wv
authors: Lichtenbelt
authors: National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
authors: Frank I
authors: FI
authors: Lin
authors: University of Iowa, Iowa City, IA 52242, USA.
authors: John J
authors: JJ
authors: Sunderland
authors: Turku University Hospital, 20500 Turku, Finland; University of Turku, 20500 Turku, Finland.
authors: Kirsi A
authors: KA
authors: Virtanen
authors: Washington University School of Medicine, Mallinckrodt Institute of Radiology, Saint Louis, MO 63110, USA.
authors: Richard L
authors: RL
authors: Wahl
mesh_terms: D002001:Adipose Tissue, Brown / Q000000981:diagnostic imaging*; D019788:Fluorodeoxyglucose F18 / Q000378:metabolism*; D017408:Guidelines as Topic; D006801:Humans; D009929:Organ Size; D000072078:Positron Emission Tomography Computed Tomography; D015203:Reproducibility of Results; D013223:Statistics as Topic
chemical_list: D019788:Fluorodeoxyglucose F18