title: Genetics of Bariatric Surgery Outcomes.
abstract: Outcomes after bariatric surgery can vary widely and seem to have a significant genetic component. Only a small number of candidate gene and genome-wide association studies have analyzed bariatric surgery outcomes. The role of bile acids in mediating the beneficial effects of bariatric surgery implicate genes regulated by the farnesoid X receptor transcription factor.
authors: Lewis Katz School of Medicine, Temple University, 3500 North Broad Street, Philadelphia, PA 19140, USA; Penn State College of Medicine, 500 University Drive, Hershey, PA 17033, USA; DNAsimple, Philadelphia, PA, USA.
authors: Olivier F
authors: OF
authors: Noel
authors: Department of Gastroenterology and Nutrition, Geisinger Clinic, 100 North Academy Avenue, Danville, PA 17822, USA.
authors: Christopher D
authors: CD
authors: Still
authors: Department of Medical Genetics and Molecular Biochemistry, Lewis Katz School of Medicine, Temple University, 960 Medical Education and Research Building (MERB), 3500 North Broad Street, Philadelphia, PA 19140, USA. Electronic address: gsgerhard@Temple.edu.
authors: Glenn S
authors: GS
authors: Gerhard
mesh_terms: D050110:Bariatric Surgery; D001647:Bile Acids and Salts; D055106:Genome-Wide Association Study; D006801:Humans; D018160:Receptors, Cytoplasmic and Nuclear / Q000235:genetics; D016896:Treatment Outcome; D015431:Weight Loss / Q000235:genetics*; D000099150:Receptor, Farnesoid X-Activated
chemical_list: D001647:Bile Acids and Salts; D018160:Receptors, Cytoplasmic and Nuclear; D000099150:Receptor, Farnesoid X-Activated
keywords: Bariatric surgery; Genetics; NAFLD; Type 2 diabetes mellitus; Weight loss