title: [Proton pump inhibitors: Real indication or trivialized prescription?]
abstract: OBJECTIVE
  Protons Pump Inhibitors (PPIs) are widely used in France. The aim of our study was to determine the rate of exposure to PPIs in old patients and to assess the appropriateness of their prescription according to French guidelines.
  
  
  METHODS
  We performed a descriptive study from 1st June to 30th August 2016, including all patients admitted in the department of geriatric post emergency of the university hospital of Toulouse with a prescription of PPI. Data concerning age, name of PPI, dose, indication, duration of prescription and the modification of PPI prescription were collected.
  
  
  RESULTS
  Among 375 patients admitted during this period, 134 (35.7) were exposed to PPIs with a mean age of 85.9±6.6years. About one third of them were exposed to PPI more than one year (N=49). Prescription was inappropriate for the criteria "dose and indication" and "duration" for respectively 59 (44.0%) and 15 (11.2%) cases. In 50 cases (37.3%), the PPI was renewed, stopped in 69 cases (51.5%) and the dose was reduced for 15 patients (11.2%).
  
  
  CONCLUSIONS
  According to our data, the prescription of PPI was no appropriate in about 40% of included patients. A reassessment of their prescription with awareness of patients should be necessary to improve the good utilization of these "popular" drugs and to prevent some serious adverse reactions after long exposure.
authors: Inserm U1027, service de pharmacologie médicale et clinique, centre Midi-Pyrénées de pharmacovigilance, de pharmacoépidémiologie et d'informations sur le médicament, CHU de Toulouse, université Paul-Sabatier, faculté de médecine, 37, allées Jules-Guesde, 31000 Toulouse, France.
authors: Jeanne
authors: J
authors: Thorel
authors: Service de pharmacie, équipe de pôle gériatrie, hôpital Paule-de-Viguier, 31059 Toulouse, France.
authors: Cécile
authors: C
authors: McCambridge
authors: Service de posturgence gériatrique, CHU de Toulouse, université Paul-Sabatier, Gérontopole, 31000 Toulouse, France.
authors: Antoine
authors: A
authors: Piau
authors: Service de posturgence gériatrique, CHU de Toulouse, université Paul-Sabatier, Gérontopole, 31000 Toulouse, France.
authors: Marion
authors: M
authors: Secher
authors: Service de pharmacie, équipe de pôle gériatrie, hôpital Paule-de-Viguier, 31059 Toulouse, France.
authors: Élodie
authors: É
authors: Magre
authors: Inserm U1027, service de pharmacologie médicale et clinique, centre Midi-Pyrénées de pharmacovigilance, de pharmacoépidémiologie et d'informations sur le médicament, CHU de Toulouse, université Paul-Sabatier, faculté de médecine, 37, allées Jules-Guesde, 31000 Toulouse, France.
authors: Jean-Louis
authors: JL
authors: Montastruc
authors: Inserm U1027, service de pharmacologie médicale et clinique, centre Midi-Pyrénées de pharmacovigilance, de pharmacoépidémiologie et d'informations sur le médicament, CHU de Toulouse, université Paul-Sabatier, faculté de médecine, 37, allées Jules-Guesde, 31000 Toulouse, France. Electronic address: haleh.bagheri@univ-tlse3.fr.
authors: Haleh
authors: H
authors: Bagheri
keywords: Adverse drug reactions; Effets indésirables; Guidelines; Inappropriate prescription; Inhibiteurs de pompe à protons; Prescription inappropriée; Proton pump inhibitors; Recommandations