title: [Expression of PTEN in Myocardial Tissue in Coronary Heart Disease].
abstract: OBJECTIVE
  To observe the expression of phosphatase and tensin homology deleted on chromosome ten (PTEN) in myocardial tissue in patients with coronary heart disease, and explore the relevance between the expression of PTEN and the occurrence and development of coronary heart disease.
  
  
  METHODS
  A total of 16 death cases with pathological diagnosis of coronary heart disease were collected as experimental group, and 19 cases without myocardial lesions were selected as control group. The expression of PTEN protein and its mRNA were detected by immunohistochemistry and real-time fluorescence quantitative PCR respectively. The correlation between the expression of PTEN and the pathogenesis of coronary heart disease was analyzed.
  
  
  RESULTS
  The expression of PTEN protein in myocardium in cases with coronary heart disease was significantly lower compared with the control group (P < 0.05). There was no statistical difference of the expression of PTEN mRNA between experimental and control group (P > 0.05).
  
  
  CONCLUSIONS
  PTEN may be involved in the occurrence and development of coronary heart disease.
authors: Xue-rong
authors: XR
authors: Li
authors: Yong
authors: Y
authors: He
authors: Yu-jia
authors: YJ
authors: Lei
authors: Xe-he
authors: XH
authors: Qin
authors: Qing-tao
authors: QT
authors: Wei
authors: Xin-min
authors: XM
authors: Pan
authors: Li-juan
authors: LJ
authors: Li
authors: Lin
authors: L
authors: Zhang
mesh_terms: D003324:Coronary Artery Disease / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D009206:Myocardium / Q000378:metabolism*; D051059:PTEN Phosphohydrolase / Q000378:metabolism*; D012333:RNA, Messenger / Q000378:metabolism
chemical_list: D012333:RNA, Messenger; D051059:PTEN Phosphohydrolase; C494929:PTEN protein, human