title: Synthesis and cytotoxicity evaluation of some new 6-nitro derivatives of thiazole-containing 4-(3H)-quinazolinone.
abstract: Quinazolinones are a group of fused heterocyclic compounds which have valuable biological properties including cytotoxic, antibacterial and antifungal activities. Thiazole group-containing compounds have been also reported to have a wide range of biological activities such as antitumor, anti-inflammatory, analgesic and antibacterial effects. Due to valuable cytotoxic effects of both thiazole groups and quinazoline derivatives, in this study a series of quinazolinone-thiazole hybrids were synthesized and evaluated for their cytotoxic effects on three cell lines including MCF-7, HT-29, and PC-3. Among tested compounds (quinazolinones and three intermediates), k5 and k6 showed highest cytotoxic activities against PC3 cell line. K6 and C were most active compounds against MCF7 and K6 showed best cytotoxicity on HT-29 cell line.
authors: Pharmaceutical sciences Research Center, School of Pharmacy, Kermanshah University of Medical Sciences, Kermanshah, I.R. Iran.
authors: Leila
authors: L
authors: Hosseinzadeh
authors: Department of Medicinal Chemistry, School of Pharmacy and Pharmaceutical Science, Kermanshah University of Medical Sciences, Kermanshah, I.R. Iran.
authors: Alireza
authors: A
authors: Aliabadi
authors: Student Research Committee, School of Pharmacy and Pharmaceutical Science, Kermanshah University of Medical Sciences, Kermanshah, I.R. Iran.
authors: Masoud
authors: M
authors: Kalantari
authors: Department of Pharmaceutics and Isfahan Pharmaceutical Sciences Research Center, School of pharmacy and pharmaceutical science, Isfahan University of Medical Sciences, I.R. Iran.
authors: Abolfazl
authors: A
authors: Mostafavi
authors: Department of Medicinal Chemistry, School of Pharmacy and Pharmaceutical Science, Kermanshah University of Medical Sciences, Kermanshah, I.R. Iran.
authors: Marzieh Rahmani
authors: MR
authors: Khajouei
keywords: Cytotoxicity; Quinazolinone; Thiazole