title: Transporters affecting biochemical test results: Creatinine-drug interactions.
abstract: Creatinine is eliminated by the kidneys through a combination of glomerular filtration and active transport. Drug-induced increases in serum creatinine (SCr) and/or reduced creatinine renal clearance are used as a marker for acute kidney injury. However, inhibition of active transport of creatinine can result in reversible and, therefore, benign increases in SCr levels. Herein, the transporters involved in creatinine clearance are discussed, in addition to limitations of using creatinine as a biomarker for kidney damage.
authors: Department of Pharmacokinetics, Pharmacodynamics and Drug Metabolism, Merck Sharp & Dohme Corporation, Kenilworth, New Jersey, USA.
authors: X
authors: X
authors: Chu
authors: Department of Pharmacokinetics, Pharmacodynamics and Drug Metabolism, Merck Sharp & Dohme Corporation, Kenilworth, New Jersey, USA.
authors: K
authors: K
authors: Bleasby
authors: Department of Pharmacokinetics, Pharmacodynamics and Drug Metabolism, Merck Sharp & Dohme Corporation, Kenilworth, New Jersey, USA.
authors: G H
authors: GH
authors: Chan
authors: GRA Onc, Immunology, Biologics & Devices, Merck Sharp & Dohme Corporation, Kenilworth, New Jersey, USA.
authors: I
authors: I
authors: Nunes
authors: Department of Pharmacokinetics, Pharmacodynamics and Drug Metabolism, Merck Sharp & Dohme Corporation, Kenilworth, New Jersey, USA. Raymond_Evers@merck.com.
authors: R
authors: R
authors: Evers
mesh_terms: D058186:Acute Kidney Injury / Q000097:blood* / Q000175:diagnosis; D000818:Animals; D015415:Biomarkers / Q000097:blood; D003404:Creatinine / Q000097:blood*; D064420:Drug-Related Side Effects and Adverse Reactions / Q000097:blood*; D006801:Humans; D008954:Models, Biological; D027701:Organic Cation Transport Proteins / Q000187:drug effects / Q000378:metabolism*
chemical_list: D015415:Biomarkers; D027701:Organic Cation Transport Proteins; D003404:Creatinine