title: Quantitative profiling of glycans and glycopeptides: an informatics' perspective.
abstract: Experimental techniques to identify and quantify glycan structures in a given sample are continuously improving. However, as they advance data analysis and annotation seems to become more complex. To address this issue, much progress has been made in developing software for interpretation of quantitative glycan profiles. Here, we focus on these informatics tools for high/ultra performance liquid chromatography (H/UPLC), mass spectrometry (MS), tandem mass spectrometry (MSn) and combinations thereof. Software for biomarker discovery, pathway, genomic and disease analysis and a final note on some future prospects for glycoinformatics are also mentioned.
authors: Bioprocessing Technology Institute, Agency for Science, Technology and Research (A*STAR), 20 Biopolis Way, #06-01 Centros, Singapore 138668, Singapore; New England Biolabs, Ipswich, MA, United States.
authors: Ian
authors: I
authors: Walsh
authors: Bioprocessing Technology Institute, Agency for Science, Technology and Research (A*STAR), 20 Biopolis Way, #06-01 Centros, Singapore 138668, Singapore.
authors: Sophie
authors: S
authors: Zhao
authors: Department of Chemistry and Biomolecular Sciences, Macquarie University, Sydney, NSW 2109, Australia.
authors: Matthew
authors: M
authors: Campbell
authors: New England Biolabs, Ipswich, MA, United States.
authors: Christopher H
authors: CH
authors: Taron
authors: Bioprocessing Technology Institute, Agency for Science, Technology and Research (A*STAR), 20 Biopolis Way, #06-01 Centros, Singapore 138668, Singapore; National Institute for Bioprocessing Research & Training, Dublin, Ireland. Electronic address: Pauline.rudd@nibrt.ie.
authors: Pauline M
authors: PM
authors: Rudd
mesh_terms: D000818:Animals; D054794:Glycomics / Q000379:methods*; D006020:Glycopeptides / Q000378:metabolism*; D006801:Humans; D011134:Polysaccharides / Q000378:metabolism*; D012984:Software
chemical_list: D006020:Glycopeptides; D011134:Polysaccharides