title: Pancreatic Cancer Chemoprevention Translational Workshop: Meeting Report.
abstract: Pancreatic cancer is the fourth leading cause of cancer related deaths in the United States with a 5-year survival rate of less than 10%. The Division of Cancer Prevention of the National Cancer Institute sponsored the Pancreatic Cancer Chemoprevention Translational Workshop on September 10 to 11, 2015. The goal of the workshop was to obtain information regarding the current state of the science and future scientific areas that should be prioritized for pancreatic cancer prevention research, including early detection and intervention for high-risk precancerous lesions. The workshop addressed the molecular/genetic landscape of pancreatic cancer and precursor lesions, high-risk populations and criteria to identify a high-risk population for potential chemoprevention trials, identification of chemopreventative/immunopreventative agents, and use of potential biomarkers and imaging for assessing short-term efficacy of a preventative agent. The field of chemoprevention for pancreatic cancer is emerging, and this workshop was organized to begin to address these important issues and promote multi-institutional efforts in this area. The meeting participants recommended the development of an National Cancer Institute working group to coordinate efforts, provide a framework, and identify opportunities for chemoprevention of pancreatic cancer.
authors: From the *Division of Cancer Prevention, National Cancer Institute, Bethesda, MD; †Department of Surgery, David M. Rubenstein Center for Pancreatic Cancer Research, Memorial Sloan Kettering Cancer Center, New York, NY; ‡Division of Gastroenterology, University of Washington at Seattle, Seattle, WA; §Department of Pathology, The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University, Baltimore, MD; ∥Department of Epidemiology, Health Sciences Research, Mayo Clinic, Rochester, MN; ¶Department of Medicine, Center for Cancer Prevention and Drug Development Program, PC Stephenson Oklahoma Cancer Center, University of Oklahoma Health Sciences Center, Oklahoma City, OK; #Division of Gastroenterology, Hepatology, and Nutrition, University of Pittsburgh Medical Center, Pittsburgh, PA; **Department of Medicine, Mayo Clinic, Rochester, MN; ††Department of Oncology, National Familial Pancreas Tumor Registry, The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University, Baltimore, MD; ‡‡Department of Surgery, Pancreatic Cancer Center, University of Michigan, Ann Arbor, MI; §§Department of Internal Medicine, Pancreatic Cancer Center, University of Michigan, Ann Arbor, MI; ∥∥Department of Surgery, Translational Oncology Program, Pancreatic Cancer Center, University of Michigan, Ann Arbor, MI; and ¶¶Department of Medicine, Pancreatic Tumor Center, Dana-Farber Cancer Institute, Harvard Medical School, Cambridge, MA.
authors: Mark Steven
authors: MS
authors: Miller
authors: Peter
authors: P
authors: Allen
authors: Teresa A
authors: TA
authors: Brentnall
authors: Michael
authors: M
authors: Goggins
authors: Ralph H
authors: RH
authors: Hruban
authors: Gloria M
authors: GM
authors: Petersen
authors: Chinthalapally V
authors: CV
authors: Rao
authors: David C
authors: DC
authors: Whitcomb
authors: Randall E
authors: RE
authors: Brand
authors: Suresh T
authors: ST
authors: Chari
authors: Alison P
authors: AP
authors: Klein
authors: David M
authors: DM
authors: Lubman
authors: Andrew D
authors: AD
authors: Rhim
authors: Diane M
authors: DM
authors: Simeone
authors: Brian M
authors: BM
authors: Wolpin
authors: Asad
authors: A
authors: Umar
authors: Sudhir
authors: S
authors: Srivastava
authors: Vernon E
authors: VE
authors: Steele
authors: Jo Ann S
authors: JA
authors: Rinaudo
mesh_terms: D015415:Biomarkers; D018890:Chemoprevention; D005544:Forecasting; D006801:Humans; D010190:Pancreatic Neoplasms; D012307:Risk Factors
chemical_list: D015415:Biomarkers