title: Potential Linkage Between Cerebrovascular Diseases and Metabolic Syndrome.
abstract: Cerebrovascular disease (CD) and metabolic syndrome (MetS) are two devastating health dilemma that continues to be a potential contributor to disability and mortality in human population all across the world. Scientific data clearly shows several mechanistic similarities between these two co-existing and interlinked conditions. The linkage exacerbates ongoing patho-physiological condition towards more lethal events. In view of the presence of modifiable risk factors in both CD and MetS, their management holds potential therapeutic value. Hence, developing common treatment strategies for these diseases could involve common molecular agents. In this communication, we have summarized some of the common pathological conditions viz. abdominal obesity, insulin resistance, dyslipidemia, hypertension, and endothelial dysfunction that further deteriorate existing homeostasis in CD and MetS. Based on our article, it is advocated that substantial improvements in novel multi-targeted drug discovery could provide the effective treatment methods in order to avoid the fatal complications related with CD and MetS.
authors: Nasimudeen R
authors: NR
authors: Jabir
authors: Chelapram Kandy
authors: CK
authors: Firoz
authors: Mohd Shahnawaz
authors: MS
authors: Khan
authors: Syed Kashif
authors: SK
authors: Zaidi
authors: Ghulam Md
authors: GM
authors: Ashraf
authors: Shazi
authors: S
authors: Shakil
authors: Mohammad Amjad
authors: MA
authors: Kamal
authors: King Fahd Medical Research Center, King Abdulaziz University, P.O. Box 80216, Jeddah 21589, Saudi Arabia.
authors: Shams
authors: S
authors: Tabrez
mesh_terms: D002561:Cerebrovascular Disorders / Q000150:complications*; D006801:Humans; D006949:Hyperlipidemias; D006973:Hypertension; D007333:Insulin Resistance; D024821:Metabolic Syndrome / Q000150:complications*; D056128:Obesity, Abdominal
keywords: Cerebrovascular disease; dislipidemia; endothelial dysfunction; hypertension; insulin resistance; metabolic syndrome; obesity