title: A hybrid polyketide-nonribosomal peptide in nematodes that promotes larval survival.
abstract: Polyketides and nonribosomal peptides are two important types of natural products that are produced by many species of bacteria and fungi but are exceedingly rare in metazoans. Here, we elucidate the structure of a hybrid polyketide-nonribosomal peptide from Caenorhabditis elegans that is produced in the canal-associated neurons (CANs) and promotes survival during starvation-induced larval arrest. Our results uncover a novel mechanism by which animals respond to nutrient fluctuations to extend survival.
authors: Department of Chemistry, University of Florida, Gainesville, Florida, USA.
authors: Qingyao
authors: Q
authors: Shou
authors: Department of Chemistry, University of Florida, Gainesville, Florida, USA.
authors: Likui
authors: L
authors: Feng
authors: Department of Chemistry, University of Florida, Gainesville, Florida, USA.
authors: Yaoling
authors: Y
authors: Long
authors: Department of Chemistry, University of Florida, Gainesville, Florida, USA.
authors: Jungsoo
authors: J
authors: Han
authors: Department of Chemistry, University of Florida, Gainesville, Florida, USA.
authors: Joshawna K
authors: JK
authors: Nunnery
authors: Department of Chemistry, University of Florida, Gainesville, Florida, USA.
authors: David H
authors: DH
authors: Powell
authors: Department of Chemistry, University of Florida, Gainesville, Florida, USA.
authors: Rebecca A
authors: RA
authors: Butcher
mesh_terms: D000818:Animals; D001688:Biological Products / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D017173:Caenorhabditis elegans / Q000166:cytology / Q000187:drug effects / Q000254:growth & development* / Q000378:metabolism*; D007814:Larva / Q000187:drug effects / Q000254:growth & development*; D009474:Neurons / Q000378:metabolism; D010455:Peptides / Q000737:chemistry / Q000378:metabolism* / Q000494:pharmacology; D061065:Polyketides / Q000737:chemistry / Q000378:metabolism* / Q000494:pharmacology
chemical_list: D001688:Biological Products; D010455:Peptides; D061065:Polyketides