title: Long-term preclinical magnetic resonance imaging alterations in sporadic Creutzfeldt-Jakob disease.
abstract: An asymptomatic 74-year-old woman, on follow-up for a carotid body tumor, showed magnetic resonance imaging (MRI) focal restricted diffusion confined to the left temporal and occipital cortices. Thirteen months later, diffusion-weighted images revealed a bilateral cortical ribbon sign involving all lobes. After 1 month, the patient developed gait instability and cognitive decline rapidly evolving to severe dementia and death within 3 months. Prion protein gene sequence, molecular, and neuropathological studies confirmed the diagnosis of sporadic Creutzfeldt-Jakob disease (sCJD) MM1 subtype. Here we show the kinetics of MRI changes and prion spreading in preclinical sCJD MM1. Ann Neurol 2016;80:629-632.
authors: Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Verona.
authors: Gianluigi
authors: G
authors: Zanusso
authors: Department of Neurosciences, University of Padua, Padua.|Neurology Unit, Sant'Antonio Hospital, Padua.
authors: Giulia
authors: G
authors: Camporese
authors: Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Verona.
authors: Sergio
authors: S
authors: Ferrari
authors: Neurology Unit, Sant'Antonio Hospital, Padua.
authors: Luca
authors: L
authors: Santelli
authors: Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Verona.
authors: Matilde
authors: M
authors: Bongianni
authors: Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Verona.
authors: Michele
authors: M
authors: Fiorini
authors: Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Verona.
authors: Salvatore
authors: S
authors: Monaco
authors: Division of Neuroradiology, Department of Medicine and Surgery, University of Salerno, Salerno.
authors: Renzo
authors: R
authors: Manara
authors: Department of Neurosciences, University of Padua, Padua. annachiara.cagnin@unipd.it.|Institute of Research and Scientific Care San Camillo Hospital Foundation, Venice, Italy. annachiara.cagnin@unipd.it.
authors: Annachiara
authors: A
authors: Cagnin
mesh_terms: D000368:Aged; D002540:Cerebral Cortex / Q000000981:diagnostic imaging*; D007562:Creutzfeldt-Jakob Syndrome / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000503:physiopathology; D018450:Disease Progression; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D062706:Prodromal Symptoms