title: Pre-Metastatic Niche Formation Has Taken Its TOLL.
abstract: Pre-Metastatic Niches (PMNs) result from communications between primary tumors and the microenvironment of future distant metastasis via tumor-derived factors. In this issue of Cancer Cell, Liu et al. show that TLR3 activation in lung epithelial cells by tumor exosomal RNAs triggers neutrophil recruitment, which contributes to PMN formation and metastasis.
authors: Children's Cancer and Blood Foundation Laboratories, Departments of Pediatrics and Cell and Developmental Biology, Drukier Institute for Children's Health, Meyer Cancer Center, Weill Cornell Medicine, New York, NY 10021, USA.
authors: Candia M
authors: CM
authors: Kenific
authors: Children's Cancer and Blood Foundation Laboratories, Departments of Pediatrics and Cell and Developmental Biology, Drukier Institute for Children's Health, Meyer Cancer Center, Weill Cornell Medicine, New York, NY 10021, USA.
authors: Laura
authors: L
authors: Nogués
authors: Children's Cancer and Blood Foundation Laboratories, Departments of Pediatrics and Cell and Developmental Biology, Drukier Institute for Children's Health, Meyer Cancer Center, Weill Cornell Medicine, New York, NY 10021, USA; Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA. Electronic address: dcl2001@med.cornell.edu.
authors: David
authors: D
authors: Lyden
mesh_terms: D004847:Epithelial Cells; D006801:Humans; D008168:Lung; D009362:Neoplasm Metastasis; D009369:Neoplasms; D012334:RNA, Neoplasm; D059016:Tumor Microenvironment
chemical_list: D012334:RNA, Neoplasm