title: The GPI anchor pathway: a promising antifungal target?
authors: Codon Capital, 545 Middlefield Road, Suite 205, Menlo Park CA 94025 USA.
authors: Mitchell
authors: M
authors: Mutz
authors: Merck Research Laboratories, 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA.
authors: Terry
authors: T
authors: Roemer
mesh_terms: D000631:Aminopyridines / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology / Q000627:therapeutic use; D000935:Antifungal Agents / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology / Q000627:therapeutic use; D017261:Glycosylphosphatidylinositols / Q000096:biosynthesis*; D006801:Humans; D007555:Isoxazoles / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology / Q000627:therapeutic use; D008565:Membrane Proteins / Q000037:antagonists & inhibitors / Q000378:metabolism; D009181:Mycoses / Q000188:drug therapy / Q000382:microbiology; D012441:Saccharomyces cerevisiae / Q000187:drug effects / Q000378:metabolism; D029701:Saccharomyces cerevisiae Proteins / Q000037:antagonists & inhibitors / Q000378:metabolism
chemical_list: C570438:APX001A; D000631:Aminopyridines; D000935:Antifungal Agents; C476345:GWT1 protein, S cerevisiae; D017261:Glycosylphosphatidylinositols; D007555:Isoxazoles; C118052:MCD4 protein, S cerevisiae; D008565:Membrane Proteins; D029701:Saccharomyces cerevisiae Proteins
keywords: antifungal; fungal infection; glycosylphosphatidylinositol; invasive; mannoprotein; mycosis; resistance; synergy