title: Population mixing and incidence of cancers in adolescents and young adults between 1990 and 2013 in Yorkshire, UK.
abstract: Epidemiological evidence suggests a role for an infectious etiology for cancers in teenagers and young adults (TYAs). We investigated this by describing associations between infection transmission using the population mixing (PM) proxy and incidence of cancers in TYAs in Yorkshire, UK.
  
  
  
  We extracted cancer cases from the Yorkshire Specialist Register of Cancer in Children and Young People from 1990 to 2013 (n = 1929). Using multivariable Poisson regression models (adjusting for effects of deprivation and population density), we investigated whether PM was associated with cancer incidence. We included population mixing-population density interaction terms to examine for differences in effects of PM in urban and rural populations.
  
  
  
  Nonsignificant IRRs were observed for leukemias (IRR 1.20, 95% CI 0.91-1.59), lymphomas (IRR 1.09, 95% CI 0.90-1.32), central nervous system tumors (IRR 1.06, 95% CI 0.80-1.40) and germ cell tumors (IRR 1.14, 95% CI 0.92-1.41). The association between PM and cancer incidence did not vary in urban and rural areas.
  
  
  
  Study results suggest PM is not associated with incidence of cancers among TYAs. This effect does not differ between rural and urban settings.
authors: Department of Paediatrics, Aminu Kano Teaching Hospital, PMB 3452 Zaria road, Kano, Nigeria.
authors: A
authors: A
authors: Imam
authors: Division of Epidemiology and Biostatistics, School of Medicine, University of Leeds, Room 8.49, Worsley Building, Clarendon Way, Leeds, LS2 9JT, UK. l.fairley@leeds.ac.uk.
authors: L
authors: 0000-0002-4280-6323
authors: L
authors: Fairley
authors: Division of Epidemiology and Biostatistics, School of Medicine, University of Leeds, Room 8.49, Worsley Building, Clarendon Way, Leeds, LS2 9JT, UK.
authors: R C
authors: RC
authors: Parslow
authors: Division of Epidemiology and Biostatistics, School of Medicine, University of Leeds, Room 8.49, Worsley Building, Clarendon Way, Leeds, LS2 9JT, UK.
authors: R G
authors: RG
authors: Feltbower
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D016543:Central Nervous System Neoplasms / Q000453:epidemiology; D005260:Female; D006801:Humans; D015994:Incidence; D007938:Leukemia / Q000453:epidemiology; D008223:Lymphoma / Q000453:epidemiology; D008297:Male; D009369:Neoplasms / Q000453:epidemiology*; D012424:Rural Population / Q000706:statistics & numerical data; D006113:United Kingdom / Q000453:epidemiology; D014505:Urban Population / Q000706:statistics & numerical data; D055815:Young Adult
keywords: Cancer; Population mixing; Teenagers and young adults