title: Donor-unrestricted T cells in the human CD1 system.
abstract: The CD1 and MHC systems are specialized for lipid and peptide display, respectively. Here, we review evidence showing how cellular CD1a, CD1b, CD1c, and CD1d proteins capture and display many cellular lipids to T cell receptors (TCRs). Increasing evidence shows that CD1-reactive T cells operate outside two classical immunogenetic concepts derived from the MHC paradigm. First, because CD1 proteins are non-polymorphic in human populations, T cell responses are not restricted to the donor's genetic background. Second, the simplified population genetics of CD1 antigen-presenting molecules can lead to simplified patterns of TCR usage. As contrasted with donor-restricted patterns of MHC-TCR interaction, the donor-unrestricted nature of CD1-TCR interactions raises the prospect that lipid agonists and antagonists of T cells could be developed.
authors: Department of Environmental Health, University of Cincinnati College of Medicine, Cincinnati, OH, 45267, USA. shouxiong.huang@uc.edu.
authors: Shouxiong
authors: S
authors: Huang
authors: Divison of Rheumatology, Immunology and Allergy, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA. bmoody@partners.org.
authors: D Branch
authors: DB
authors: Moody
mesh_terms: D017951:Antigen Presentation; D018949:Antigens, CD1 / Q000276:immunology*; D006801:Humans; D008055:Lipids / Q000276:immunology*; D011948:Receptors, Antigen, T-Cell / Q000276:immunology*; D016176:T-Lymphocyte Subsets / Q000276:immunology*; D014019:Tissue Donors
chemical_list: D018949:Antigens, CD1; D008055:Lipids; D011948:Receptors, Antigen, T-Cell
keywords: Autoreactivity; A’ roof; CD1; Donor-unrestricted T cells; Lipid antigens; T cell receptor