title: A multidisciplinary approach to prenatal treatment of congenital long QT syndrome.
abstract: A 27-week fetus evaluated for bradycardia and hydrops was found to have anti-SSA-negative 2° atrioventricular block and ventricular tachycardia. A presumptive diagnosis of fetal long QT syndrome was made. Transplacental pharmacotherapy with intravenous magnesium and lidocaine restored sinus rhythm. At 30 6/7 weeks, the infant was delivered due to premature labor. Despite postnatal treatment with mexiletine and propranolol, she developed torsades de pointes. Ultimately, a de novo KCNH2 G628S mutation was diagnosed. She received an implantable cardiac defibrillator at 5 months of age. Early diagnosis and a multidisciplinary approach allowed successful in utero treatment and anticipatory postnatal management. © 2016 Wiley Periodicals, Inc. J Clin Ultrasound 45:168-170, 2017.
authors: Fetal Heart Program, Center for Advanced Fetal Care, Department of Obstetrics, Gynecology, and Reproductive Sciences, University of Maryland School of Medicine, Sixth Floor, Room 6NE11, 22 South Greene Street, Baltimore, MD, 21201.
authors: Sarah
authors: S
authors: Crimmins
authors: Department of Pediatrics, University of Maryland School of Medicine, Baltimore, MD, 21201.
authors: Sudhir
authors: S
authors: Vashit
authors: Fetal Heart Program, Center for Advanced Fetal Care, Department of Obstetrics, Gynecology, and Reproductive Sciences, University of Maryland School of Medicine, Sixth Floor, Room 6NE11, 22 South Greene Street, Baltimore, MD, 21201.
authors: Lauren
authors: L
authors: Doyle
authors: Fetal Heart Program, Center for Advanced Fetal Care, Department of Obstetrics, Gynecology, and Reproductive Sciences, University of Maryland School of Medicine, Sixth Floor, Room 6NE11, 22 South Greene Street, Baltimore, MD, 21201.
authors: Chris
authors: C
authors: Harman
authors: Fetal Heart Program, Center for Advanced Fetal Care, Department of Obstetrics, Gynecology, and Reproductive Sciences, University of Maryland School of Medicine, Sixth Floor, Room 6NE11, 22 South Greene Street, Baltimore, MD, 21201.
authors: Ozhan
authors: O
authors: Turan
authors: Fetal Heart Program, Center for Advanced Fetal Care, Department of Obstetrics, Gynecology, and Reproductive Sciences, University of Maryland School of Medicine, Sixth Floor, Room 6NE11, 22 South Greene Street, Baltimore, MD, 21201.
authors: Sifa
authors: S
authors: Turan
mesh_terms: D000328:Adult; D004562:Electrocardiography; D005260:Female; D000070276:Heart Rate Determination / Q000379:methods; D006801:Humans; D008012:Lidocaine / Q000627:therapeutic use; D008133:Long QT Syndrome / Q000175:diagnosis* / Q000196:embryology / Q000628:therapy*; D008274:Magnesium / Q000627:therapeutic use; D008991:Monitoring, Physiologic / Q000379:methods; D011247:Pregnancy; D011296:Prenatal Diagnosis / Q000379:methods*; D016216:Ultrasonography, Prenatal; D055815:Young Adult
chemical_list: D008012:Lidocaine; D008274:Magnesium
keywords: hydrops; long QT; prenatal diagnosis