title: Dual Catalysis Using Boronic Acid and Chiral Amine: Acyclic Quaternary Carbons via Enantioselective Alkylation of Branched Aldehydes with Allylic Alcohols.
abstract: A ferrocenium boronic acid salt activates allylic alcohols to generate transient carbocations that react with in situ-generated chiral enamines from branched aldehydes. The optimized conditions afford the desired acyclic products embedding a methyl-aryl quaternary carbon center with up to 90% yield and 97:3 enantiomeric ratio, with only water as the byproduct. This noble-metal-free method complements alternative methods that are incompatible with carbon-halogen bonds and other sensitive functional groups.
authors: Department of Chemistry, Centennial Centre for Interdisciplinary Science, University of Alberta , Edmonton, Alberta T6G 2G2, Canada.
authors: Xiaobin
authors: X
authors: Mo
authors: Department of Chemistry, Centennial Centre for Interdisciplinary Science, University of Alberta , Edmonton, Alberta T6G 2G2, Canada.
authors: Dennis G
authors: DG
authors: Hall