title: Surgical Treatment of Subretinal Fibrosis Caused Macular Detachment in Vogt-Koyanagi-Harada Disease: A Pioneer Study.
abstract: OBJECTIVE
  To describe surgical outcomes of macular detachment caused by subretinal fibrosis (SRF) in Vogt-Koyanagi-Harada disease (VKH).
  
  
  METHODS
  Retrospective review of VKH patients who underwent SRF removal surgery.
  
  
  RESULTS
  Seven eyes of six VKH patients with preoperative BCVA ranging from light perception to 20/250 were included. Six eyes underwent uncomplicated SRF removal with C3F8 or silicone oil (SO) tamponade and the following optional primary or subsequent procedures: intravitreal injection of triamcinolone acetonide, SO removal, lensectomy, or phacoemulsification with intraocular lens (IOL) implantation. All six eyes had attached macula and improved BCVA at the last visit (ranging from 20/2000 to 20/67) compared to baseline; the other eye, however, showed no light perception after surgery due to optic nerve injury.
  
  
  CONCLUSIONS
  In VKH patients, macular detachment caused by SRF can be treated with surgery with generally favorable outcomes. Extreme caution should be taken to avoid optic nerve injury.
authors: a Ophthalmology Department, Peking Union Medical College Hospital , Chinese Academy of Medical Sciences , Beijing , China.
authors: Chan
authors: C
authors: Zhao
authors: a Ophthalmology Department, Peking Union Medical College Hospital , Chinese Academy of Medical Sciences , Beijing , China.
authors: Meifen
authors: M
authors: Zhang
authors: a Ophthalmology Department, Peking Union Medical College Hospital , Chinese Academy of Medical Sciences , Beijing , China.
authors: Fei
authors: F
authors: Gao
authors: a Ophthalmology Department, Peking Union Medical College Hospital , Chinese Academy of Medical Sciences , Beijing , China.
authors: Fangtian
authors: F
authors: Dong
mesh_terms: D000328:Adult; D058450:Endotamponade; D005260:Female; D005355:Fibrosis; D005466:Fluorocarbons / Q000008:administration & dosage; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008875:Middle Aged; D013508:Ophthalmologic Surgical Procedures; D012160:Retina / Q000473:pathology*; D012163:Retinal Detachment / Q000209:etiology / Q000503:physiopathology / Q000601:surgery*; D012189:Retrospective Studies; D012827:Silicone Oils / Q000008:administration & dosage; D014222:Triamcinolone Acetonide / Q000627:therapeutic use; D014607:Uveomeningoencephalitic Syndrome / Q000150:complications* / Q000503:physiopathology; D014792:Visual Acuity / Q000502:physiology; D055815:Young Adult
chemical_list: D005466:Fluorocarbons; D005938:Glucocorticoids; D012827:Silicone Oils; C042852:perflutren; D014222:Triamcinolone Acetonide
keywords: Macular detachment; Vogt-Koyanagi-Harada disease; spectral domain optical coherence tomography; subretinal fibrosis; surgery