title: Nonparametric Model of Smooth Muscle Force Production During Electrical Stimulation.
abstract: A nonparametric model of smooth muscle tension response to electrical stimulation was estimated using the Laguerre expansion technique of nonlinear system kernel estimation. The experimental data consisted of force responses of smooth muscle to energy-matched alternating single pulse and burst current stimuli. The burst stimuli led to at least a 10-fold increase in peak force in smooth muscle from Mytilus edulis, despite the constant energy constraint. A linear model did not fit the data. However, a second-order model fit the data accurately, so the higher-order models were not required to fit the data. Results showed that smooth muscle force response is not linearly related to the stimulation power.
authors: 1 Department of Biomedical Engineering, University of Southern California Viterbi School of Engineering , Los Angeles, California.
authors: Marc
authors: M
authors: Cole
authors: 1 Department of Biomedical Engineering, University of Southern California Viterbi School of Engineering , Los Angeles, California.|2 Biomedical Simulations Resource, Department of Biomedical Engineering, University of Southern California , Los Angeles, California.
authors: Steffen
authors: S
authors: Eikenberry
authors: 3 Department of General Education, National Institute of Technology, Toyota College, Toyota, Japan .
authors: Takahide
authors: T
authors: Kato
authors: 1 Department of Biomedical Engineering, University of Southern California Viterbi School of Engineering , Los Angeles, California.|2 Biomedical Simulations Resource, Department of Biomedical Engineering, University of Southern California , Los Angeles, California.
authors: Roman A
authors: RA
authors: Sandler
authors: 1 Department of Biomedical Engineering, University of Southern California Viterbi School of Engineering , Los Angeles, California.
authors: Stanley M
authors: SM
authors: Yamashiro
authors: 1 Department of Biomedical Engineering, University of Southern California Viterbi School of Engineering , Los Angeles, California.|2 Biomedical Simulations Resource, Department of Biomedical Engineering, University of Southern California , Los Angeles, California.
authors: Vasilis Z
authors: VZ
authors: Marmarelis
mesh_terms: D000818:Animals; D004558:Electric Stimulation; D015233:Models, Statistical; D009119:Muscle Contraction / Q000502:physiology*; D009130:Muscle, Smooth / Q000502:physiology*; D049880:Mytilus edulis / Q000502:physiology*; D013816:Thermodynamics
keywords: Laguerre expansion; Volterra kernels; electrical stimulation; model prediction; nonlinear system