title: Association between Exposure to Endocrine Disruptors in Drinking Water and Preterm Birth, Taking Neighborhood Deprivation into Account: A Historic Cohort Study.
abstract: The relationship between preterm birth (PTB) and endocrine disruptor exposure in drinking-water has only occasionally been studied. The objective of this work was to investigate the relation between exposure to atrazine metabolites, or atrazine/nitrate mixtures, in drinking-water during pregnancy and prevalence of PTB neonates, while taking neighborhood deprivation into account.
  
  
  
  A historic cohort study in Deux-Sèvres, France, between 2005 and 2010 with a multiple imputation model for data of exposure to atrazine metabolites and a logistic regression were carried out.
  
  
  
  We included 13,654 mother/neonate pairs living in 279 different census districts. The prevalence of PTB was 4%. Average atrazine metabolite concentration was 0.019 ± 0.009 (0.014-0.080) µg/L and 39% of mothers lived in less deprived areas. The individual data were associated with risk of PTB. The risk of PTB when exposed to highest concentration of atrazine metabolite adjusted for confounders, was ORa 1.625 95% CI [0.975; 2.710]. Taking, or not, neighborhood deprivation into account did not change the result. Exposure to atrazine/nitrate mixtures remained non-significant.
  
  
  
  Even if we took neighborhood deprivation into account, we could not show a significant relationship between exposure to atrazine metabolites, or mixtures, in drinking-water during the second trimester of pregnancy and PTB.
authors: Department of Analytical Chemistry, Pharmaceutics and Epidemiology, School of Medicine and Pharmacy, University of Poitiers, 6 rue de la Milétrie, 86034 Poitiers Cedex, France. marion.albouy-llaty@chu-poitiers.fr.|Health-Endocrine Disruptors-EXposome, Clinical Investigation Center, Inserm U1402, 86021 Poitiers Cedex, France. marion.albouy-llaty@chu-poitiers.fr.|Teaching Hospital of Poitiers, Biology-Pharmacy-Public Health Pole, 2 rue de la Milétrie, BP577, 86021 Poitiers Cedex, France. marion.albouy-llaty@chu-poitiers.fr.
authors: Marion
authors: M
authors: Albouy-Llaty
authors: Department of Analytical Chemistry, Pharmaceutics and Epidemiology, School of Medicine and Pharmacy, University of Poitiers, 6 rue de la Milétrie, 86034 Poitiers Cedex, France. frederike.limousi@gmail.com.
authors: Frédérike
authors: F
authors: Limousi
authors: Epidemiology of Cancer and Environmental Exposures, Inserm U1219, University of Bordeaux, 146 rue Léo Saignat, 33076 Bordeaux, France. Camille.Carles@isped.u-bordeaux2.fr.
authors: Camille
authors: C
authors: Carles
authors: Department of Analytical Chemistry, Pharmaceutics and Epidemiology, School of Medicine and Pharmacy, University of Poitiers, 6 rue de la Milétrie, 86034 Poitiers Cedex, France. antoine.dupuis@univ-poitiers.fr.|Health-Endocrine Disruptors-EXposome, Clinical Investigation Center, Inserm U1402, 86021 Poitiers Cedex, France. antoine.dupuis@univ-poitiers.fr.|Teaching Hospital of Poitiers, Biology-Pharmacy-Public Health Pole, 2 rue de la Milétrie, BP577, 86021 Poitiers Cedex, France. antoine.dupuis@univ-poitiers.fr.
authors: Antoine
authors: A
authors: Dupuis
authors: Department of Analytical Chemistry, Pharmaceutics and Epidemiology, School of Medicine and Pharmacy, University of Poitiers, 6 rue de la Milétrie, 86034 Poitiers Cedex, France. sylvie.rabouan@univ-poitiers.fr.|Health-Endocrine Disruptors-EXposome, Clinical Investigation Center, Inserm U1402, 86021 Poitiers Cedex, France. sylvie.rabouan@univ-poitiers.fr.
authors: Sylvie
authors: S
authors: Rabouan
authors: Department of Analytical Chemistry, Pharmaceutics and Epidemiology, School of Medicine and Pharmacy, University of Poitiers, 6 rue de la Milétrie, 86034 Poitiers Cedex, France. virginie.migeot@univ-poitiers.fr.|Health-Endocrine Disruptors-EXposome, Clinical Investigation Center, Inserm U1402, 86021 Poitiers Cedex, France. virginie.migeot@univ-poitiers.fr.|Teaching Hospital of Poitiers, Biology-Pharmacy-Public Health Pole, 2 rue de la Milétrie, BP577, 86021 Poitiers Cedex, France. virginie.migeot@univ-poitiers.fr.
authors: Virginie
authors: V
authors: Migeot
mesh_terms: D000328:Adult; D001280:Atrazine; D015331:Cohort Studies; D060766:Drinking Water / Q000378:metabolism*; D052244:Endocrine Disruptors / Q000009:adverse effects* / Q000494:pharmacology*; D005260:Female; D005602:France / Q000453:epidemiology; D006801:Humans; D007231:Infant, Newborn; D016015:Logistic Models; D009566:Nitrates; D011204:Poverty Areas; D011247:Pregnancy; D047928:Premature Birth / Q000139:chemically induced* / Q000453:epidemiology; D015995:Prevalence; D012111:Residence Characteristics; D055815:Young Adult
chemical_list: D060766:Drinking Water; D052244:Endocrine Disruptors; D009566:Nitrates; D001280:Atrazine
keywords: European deprivation index; drinking-water; endocrine disruptor; mixture; preterm birth; social inequalities