title: Rationale and protocol of AIRC IG-13218, short-term radiotherapy for early prostate cancer with concomitant boost to the dominant lesion.
abstract: BACKGROUND
  Of the different treatments for early prostate cancer, hypofractionated external-beam radiotherapy is one of the most interesting and studied options.
  
  
  METHODS
  The main objective of this phase II clinical study is to evaluate the feasibility, in terms of the incidence of acute side effects, of a new ultra-hypofractionated scheme for low- or intermediate-risk prostate cancer patients treated with the latest imaging and radiotherapy technology, allowing dose escalation to the dominant intraprostatic lesion identified by multiparametric magnetic resonance imaging. Secondary endpoints of the study are the evaluation of the long-term tolerability of the treatment in terms of late side effects, quality of life, and efficacy (oncological outcome).
  
  
  RESULTS
  The study is ongoing, and we expect to complete recruitment by the end of 2016.
  
  
  CONCLUSIONS
  Like in previous studies, we expect ultra-hypofractionated radiation treatment for prostate cancer to be well tolerated and effective.
  
  
  BACKGROUND
  ClinicalTrials.gov identifier: NCT01913717.
authors:  Department of Radiotherapy, European Institute of Oncology, Milan - Italy.
authors: Giorgia
authors: G
authors: Timon
authors:  Department of Radiotherapy, European Institute of Oncology, Milan - Italy.
authors: Delia
authors: D
authors: Ciardo
authors:  Department of Medical Physics, European Institute of Oncology, Milan - Italy.
authors: Alessia
authors: A
authors: Bazani
authors:  Department of Medical Physics, European Institute of Oncology, Milan - Italy.| Department of Health Science, University of Milan, Milan - Italy.
authors: Maria
authors: M
authors: Garioni
authors:  Department of Medical Physics, European Institute of Oncology, Milan - Italy.| Department of Health Science, University of Milan, Milan - Italy.
authors: Davide
authors: D
authors: Maestri
authors:  Scientific Direction, European Institute of Oncology, Milan - Italy.
authors: Daniela
authors: D
authors: De Lorenzo
authors:  Department of Medical Physics, European Institute of Oncology, Milan - Italy.
authors: Floriana
authors: F
authors: Pansini
authors:  Department of Medical Physics, European Institute of Oncology, Milan - Italy.
authors: Raffaella
authors: R
authors: Cambria
authors:  Department of Medical Physics, European Institute of Oncology, Milan - Italy.
authors: Elena
authors: E
authors: Rondi
authors:  Department of Medical Physics, European Institute of Oncology, Milan - Italy.
authors: Federica
authors: F
authors: Cattani
authors:  Department of Radiotherapy, European Institute of Oncology, Milan - Italy.
authors: Giulia
authors: G
authors: Marvaso
authors:  Department of Radiotherapy, European Institute of Oncology, Milan - Italy.
authors: Dario
authors: D
authors: Zerini
authors:  Clinical Division, National Center of Oncological Hadrontherapy, Pavia - Italy.
authors: Barbara
authors: B
authors: Vischioni
authors:  Medical Physics Division, National Center of Oncological Hadron Therapy, Pavia - Italy.
authors: Mario
authors: M
authors: Ciocca
authors:  Medical Physics Division, National Center of Oncological Hadron Therapy, Pavia - Italy.
authors: Stefania
authors: S
authors: Russo
authors:  Medical Physics Division, National Center of Oncological Hadron Therapy, Pavia - Italy.
authors: Silvia
authors: S
authors: Molinelli
authors:  Department of Radiotherapy, European Institute of Oncology, Milan - Italy.
authors: Federica
authors: F
authors: Golino
authors:  Department of Radiotherapy, European Institute of Oncology, Milan - Italy.
authors: Valerio
authors: V
authors: Scroffi
authors:  Department of Radiotherapy, European Institute of Oncology, Milan - Italy.| Department of Health Science, University of Milan, Milan - Italy.
authors: Damaris P
authors: DP
authors: Rojas
authors:  Department of Radiotherapy, European Institute of Oncology, Milan - Italy.
authors: Cristiana
authors: C
authors: Fodor
authors:  Department of Radiology, European Institute of Oncology, Milan - Italy.
authors: Giuseppe
authors: G
authors: Petralia
authors:  Department of Epidemiology and Biostatistics, European Institute of Oncology, Milan - Italy.
authors: Luigi
authors: L
authors: Santoro
authors:  Department of Urology, European Institute of Oncology, Milan - Italy.
authors: Ottavio
authors: O
authors: De Cobelli
authors:  Department of Health Science, University of Milan, Milan - Italy.| Scientific Direction, European Institute of Oncology, Milan - Italy.
authors: Roberto
authors: R
authors: Orecchia
authors:  Department of Radiotherapy, European Institute of Oncology, Milan - Italy.| Department of Health Science, University of Milan, Milan - Italy.
authors: Barbara A
authors: BA
authors: Jereczek-Fossa
mesh_terms: D006801:Humans; D008297:Male; D014408:Biomarkers, Tumor; D019583:Dose Fractionation, Radiation; D061705:Image-Guided Biopsy; D008279:Magnetic Resonance Imaging; D009367:Neoplasm Staging; D011379:Prognosis; D011471:Prostatic Neoplasms / Q000175:diagnosis / Q000532:radiotherapy; D000069473:Radiation Dose Hypofractionation; D011879:Radiotherapy Dosage; D011880:Radiotherapy Planning, Computer-Assisted; D012107:Research Design
chemical_list: D014408:Biomarkers, Tumor