title: Antibacterial nanohydroxyapatite/polyurethane composite scaffolds with silver phosphate particles for bone regeneration.
abstract: Solving the issue of infection associated with implanted bone substitutes is one of the modern challenges of the biomedical engineering field. The purpose of this study was to develop a novel porous scaffold with sufficient antibacterial activity for bone repair or regeneration. Porous nanohydroxyapatite/polyurethane (n-HA/PU) composite scaffolds containing different amounts of silver phosphate particles were prepared through the in situ foaming method. Subsequently, their physicochemical properties, antibacterial abilities, and preliminary cytocompatibilities were evaluated. The results indicated that the porosity and mechanical properties of the n-HA/PU scaffolds incorporated with Ag3PO4 did not change significantly compared to n-HA/PU scaffold without Ag3PO4. The release of Ag(+) was time and concentration dependent, increasing with the immersion time and Ag3PO4 percentage in the scaffolds. A continuous Ag(+) release can last more than 3 weeks. The antibacterial tests and cytocompatibility evaluation revealed that n-HA/PU scaffolds with 3 wt% Ag3PO4 (n-HA/PU3) exhibit stronger antimicrobial effects as well as satisfactory cytocompatibility. The n-HA/PU3 scaffolds may hold great potential for application in the field of bone regeneration, especially for infection-associated bone defect repair.
authors: a Research Center for Nano-Biomaterials, Analytical & Testing Center , Sichuan University , Chengdu , China.
authors: Jiaxing
authors: J
authors: Jiang
authors: a Research Center for Nano-Biomaterials, Analytical & Testing Center , Sichuan University , Chengdu , China.
authors: Limei
authors: L
authors: Li
authors: a Research Center for Nano-Biomaterials, Analytical & Testing Center , Sichuan University , Chengdu , China.
authors: Kuankuan
authors: K
authors: Li
authors: a Research Center for Nano-Biomaterials, Analytical & Testing Center , Sichuan University , Chengdu , China.
authors: Gen
authors: G
authors: Li
authors: b Division of Biomedical Engineering , College of Engineering, University of Saskatchewan , Saskatoon , Canada.
authors: Fu
authors: F
authors: You
authors: a Research Center for Nano-Biomaterials, Analytical & Testing Center , Sichuan University , Chengdu , China.
authors: Yi
authors: Y
authors: Zuo
authors: a Research Center for Nano-Biomaterials, Analytical & Testing Center , Sichuan University , Chengdu , China.
authors: Yubao
authors: Y
authors: Li
authors: a Research Center for Nano-Biomaterials, Analytical & Testing Center , Sichuan University , Chengdu , China.
authors: Jidong
authors: J
authors: Li
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology* / Q000633:toxicity; D001861:Bone Regeneration / Q000187:drug effects*; D045744:Cell Line, Tumor; D017886:Durapatite / Q000737:chemistry*; D004926:Escherichia coli / Q000187:drug effects; D006801:Humans; D055595:Mechanical Phenomena; D049329:Nanostructures / Q000737:chemistry* / Q000633:toxicity; D010710:Phosphates / Q000737:chemistry*; D011140:Polyurethanes / Q000737:chemistry*; D018030:Silver Compounds / Q000737:chemistry*; D013211:Staphylococcus aureus / Q000187:drug effects
chemical_list: D000900:Anti-Bacterial Agents; D010710:Phosphates; D011140:Polyurethanes; D018030:Silver Compounds; D017886:Durapatite; C039072:silver phosphate
keywords: Antibacterial; bone regeneration; polyurethane; silver phosphate particles