title: Expression of maspin in testis tumors with germ cells andits relation with angiogenesis factors.
abstract: OBJECTIVE
  We aimed to evaluate the importance of maspin expression in testicular tumors with germ cells, its effect on prognosis, and the relation with angiogenesis factors.
  
  
  METHODS
  The paraffin blocks of the orchiectomy materials of 32 patients who had undergone orchiectomy due to testicular tumors were taken within the scope of the study. The specimens of the cases included in the study group were reexamined under light microscope.
  
  
  RESULTS
  While just one maspin-positive sample was found in the seminoma cases, maspin stained positively in 6 of the nonseminoma germ cell tumors (NSGCTs). No statistical difference was found between maspin and tumor stage, size, alpha fetoprotein values, vascular endothelial growth factor, Ki-67, and CD31. A statistically positive correlation was only determined between maspin and p53 (P < 0.001).
  
  
  CONCLUSIONS
  Maspin protein, whose expression in some tumors is accepted as a poor prognostic factor, is also expressed in testicular tumors with germ cells. However, according to our study, it is difficult to say whether this protein is a favorable or poor prognostic factor in testicular tumors and to understand how the effect mechanism works. The positive correlation between maspin and p53 in the NSGCTs makes us think that maspin might have displayed an effect on the p53 pathway.
authors: Department of Urology, Faculty of Medicine, İnönü University, Malatya, Turkey.
authors: Hüseyin
authors: H
authors: Çelik
authors: Department of Urology, Faculty of Medicine, Başkent University, Adana, Turkey.
authors: Tahsin
authors: T
authors: Turunç
authors: Department of Pathology, Faculty of Medicine, Başkent University, Adana, Turkey.
authors: Nebil
authors: N
authors: Bal
authors: Department of Urology, Faculty of Medicine, Başkent University, Adana, Turkey.
authors: Eray
authors: E
authors: Hasirci
authors: Department of Urology, Batman State Hospital, Batman, Turkey.
authors: Alaaddin
authors: A
authors: Akay
authors: Department of Urology, Faculty of Medicine, Başkent University, Adana, Turkey.
authors: Çetin Levent
authors: ÇL
authors: Peşkircioğlu
mesh_terms: D043925:Angiogenesis Inducing Agents; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D011379:Prognosis; D015843:Serpins; D013736:Testicular Neoplasms
chemical_list: D043925:Angiogenesis Inducing Agents; C085344:SERPIN-B5; D015843:Serpins
keywords: Testicular tumor; germ cell; maspin; p53; vascular endothelial growth factor