title: Enzymatic conversion of magnetic nanoparticles to a non-magnetic precipitate: a new approach to magnetic sensing.
abstract: Magnetic sensing utilizes the detection of biomolecule-conjugated magnetic nanoparticles (MNPs). Our new strategy offers a novel approach to magnetic sensing where in situ conversion produces a "loss of signal" in the sensing device. This report demonstrates the enzymatic conversion of Fe3O4 MNPs to a non-magnetic precipitate via reduction by l-ascorbic acid generated by the action of alkaline phosphatase.
authors: Department of Chemistry and Texas Center for Superconductivity, University of Houston, 4800 Calhoun Road, Houston, TX 77204, USA. litvinov@uh.edu trlee@uh.edu.
authors: Arati G
authors: AG
authors: Kolhatkar
authors: Andrew C
authors: AC
authors: Jamison
authors: Ivan
authors: I
authors: Nekrashevich
authors: Katerina
authors: K
authors: Kourentzi
authors: Dmitri
authors: D
authors: Litvinov
authors: Audrius
authors: A
authors: Brazdeikis
authors: Richard C
authors: RC
authors: Willson
authors: T
authors: T
authors: Randall Lee
mesh_terms: D000469:Alkaline Phosphatase / Q000737:chemistry*; D001205:Ascorbic Acid / Q000737:chemistry*; D058185:Magnetite Nanoparticles
chemical_list: D058185:Magnetite Nanoparticles; D000469:Alkaline Phosphatase; D001205:Ascorbic Acid