title: Agomelatine and Transient Elevation of Creatine Phosphokinase.
abstract: Agomelatine is an antidepressant drug with moderate agonistic action at the melatonine receptor MT1 and weak effect at MT2. According to clinical studies, agomelatine ameliorates depressive symptoms and improves sleep quality. Side effects such as elevated liver enzymes are well-known. Therefore, routine laboratory monitoring of liver function is recommended periodically throughout treatment because of a rare risk of more serious liver reactions. 2 patients with creatine phosphokinase elevation during treatment with agomelatine are presented. We recommend a check of the creatine phosphokinase level during the initial treatment phase in patients receiving agomelatine for the first time.
authors: Department of Psychiatry, University of Basel, Basel, Switzerland.
authors: A
authors: A
authors: Zormann
authors: Department of Psychiatry, University of Basel, Basel, Switzerland.
authors: J
authors: J
authors: Blum
authors: Clinical Pharmacology and Toxicology, University Hospital Basel, Basel, Switzerland.
authors: C
authors: C
authors: Suenderhauf
authors: Department of Psychiatry, University of Basel, Basel, Switzerland.
authors: M
authors: M
authors: Vogel
authors: Department of Psychiatry, University of Basel, Basel, Switzerland.
authors: A
authors: A
authors: Walter
mesh_terms: D000081:Acetamides / Q000009:adverse effects* / Q000627:therapeutic use; D000328:Adult; D000928:Antidepressive Agents / Q000009:adverse effects* / Q000627:therapeutic use; D003402:Creatine Kinase / Q000378:metabolism*; D003863:Depression / Q000188:drug therapy / Q000378:metabolism; D006801:Humans; D008099:Liver / Q000187:drug effects* / Q000201:enzymology; D008111:Liver Function Tests / Q000379:methods; D008297:Male; D008550:Melatonin / Q000378:metabolism; D044122:Receptor, Melatonin, MT1 / Q000378:metabolism; D044123:Receptor, Melatonin, MT2 / Q000378:metabolism; D009281:Naphthalenes
chemical_list: D000081:Acetamides; D000928:Antidepressive Agents; D003402:Creatine Kinase; D008550:Melatonin; D044122:Receptor, Melatonin, MT1; D044123:Receptor, Melatonin, MT2; C084711:agomelatine; D009281:Naphthalenes