title: DcR3 gene polymorphisms are associated with sporadic breast infiltrating ductal carcinoma in Northeast Chinese women.
abstract: Decoy Receptor 3 (DcR3), also called TNFRSF6β, is a member of the tumor necrosis factor receptor superfamily and is a soluble receptor for FasL. DcR3 is overexpressed in cancers and contributes to tumorigenesis through immune suppression and promotion of angiogenesis. We found that DcR3 is overexpressed in breast infiltrating ductal carcinoma (IDC) cells as compared with normal controls. We also conducted a case-control study analyzing associations of DcR3 polymorphisms with breast IDC risk. Subjects included 531 females with breast IDC and 592 age-matched healthy controls. Four DcR3 single nucleotide polymorphism loci with minor frequencies of more than 5% (rs3208008, rs41309931, rs2297441 and rs1291207) were genotyped using polymerase chain reaction restriction fragment length polymorphism and sequencing. Our results revealed significant differences in rs41309931genotypes and alleles (P < 0.01). Based on Haploview software analysis, the haplotype block Ars3208008 Grs41309931 Grs2297441 Ars1291207 exhibited the highest frequency, but, haplotype blocks Ars3208008 Trs41309931 Grs2297441 Ars1291207 and Crs3208008 Grs41309931 Grs2297441 Ars1291207 were associated with breast IDC risk. This study also detected associations between DcR3 gene polymorphisms and the clinicopathological features of breast IDC, including lymph node metastasis and C-erbB2, P53, estrogen receptor and progesterone receptor status. These data indicate that DcR3 gene polymorphisms are associated with sporadic breast IDC risk in Northeast Chinese females.
authors: Heilongjiang Provincial Key Laboratory for Infection and Immunity, Harbin Medical University and Heilongjiang Academy of Medical Science, 150081 Harbin, China.
authors: Zhenkun
authors: Z
authors: Fu
authors: Heilongjiang Provincial Key Laboratory for Infection and Immunity, Harbin Medical University and Heilongjiang Academy of Medical Science, 150081 Harbin, China.|Department of Immunology, Harbin Medical University and Heilongjiang Academy of Medical Science, 150081 Harbin, China.
authors: Shuang
authors: S
authors: Chen
authors: Department of Immunology, Harbin Medical University and Heilongjiang Academy of Medical Science, 150081 Harbin, China.
authors: Shengwei
authors: S
authors: Liu
authors: Department of Immunology, Harbin Medical University and Heilongjiang Academy of Medical Science, 150081 Harbin, China.
authors: Shaoli
authors: S
authors: Han
authors: Department of Immunology, Harbin Medical University and Heilongjiang Academy of Medical Science, 150081 Harbin, China.
authors: Xiang
authors: X
authors: Gao
authors: Department of Breast Surgery, The Third Affiliated Hospital of Harbin Medical University, 150081 Harbin, China.
authors: Dalin
authors: D
authors: Li
authors: Heilongjiang Provincial Key Laboratory for Infection and Immunity, Harbin Medical University and Heilongjiang Academy of Medical Science, 150081 Harbin, China.|Department of Immunology, Harbin Medical University and Heilongjiang Academy of Medical Science, 150081 Harbin, China.
authors: Dianjun
authors: D
authors: Li
mesh_terms: D000328:Adult; D000483:Alleles; D044466:Asian People / Q000235:genetics; D001943:Breast Neoplasms / Q000208:ethnology / Q000235:genetics* / Q000473:pathology; D018270:Carcinoma, Ductal, Breast / Q000208:ethnology / Q000235:genetics* / Q000473:pathology; D016022:Case-Control Studies; D002681:China; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D008207:Lymphatic Metastasis; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D012150:Polymorphism, Restriction Fragment Length; D053323:Receptors, Tumor Necrosis Factor, Member 6b / Q000235:genetics*
chemical_list: D053323:Receptors, Tumor Necrosis Factor, Member 6b; C505911:TNFRSF6B protein, human
keywords: DcR3; TNFRSF6β; breast infiltrating ductal carcinoma; haplotype; single nucleotide polymorphism