title: Should urinary iodine concentrations of school-aged children continue to be used as proxy for different populations? Analysis of data from Chinese national surveys.
abstract: I deficiency is a worldwide public health problem. Median urinary I concentration in school-aged children has been used globally as a proxy for all populations. This study aims to determine whether median urinary I concentration of school-aged children is an appropriate indicator of I nutritional status in different adult populations. This is a secondary data analysis of two national I Deficiency Disorder surveys (2011, 2014) and two regional surveys (in coastal areas, 2009, and in high-risk areas, 2009-2014). Population groups included in these surveys were school-aged children (8-10 years), pregnant women, lactating women, women of childbearing age and adults (men and women, 18-45 years). All participants were self-reported healthy without history of thyroid diseases or were not using thyroid medicines. The median urinary I concentration of school-aged children was matched with that of the other population at the county level. The matched populations had similar iodised salt supply, food and water I, food composition and I content in salt. Weak or moderate correlation of median urinary I concentrations was observed between school-aged children and pregnant women and between children and lactating women. However, the agreement was stronger between children and women of childbearing age and between children and adult men and women. The results could be affected by cut-off values, data aggregation level and sample size. Using median urinary I concentration of school-aged children tends to overestimate that of pregnant women and lactating women. Median urinary I concentration of school-aged children can be used for assessing I nutrition in the adult population.
authors: 1Key Lab of Etiology and Epidemiology,Education Bureau of Heilongjiang Province & Ministry of Health,Center for Endemic Disease Control,Chinese Center for Disease Control and Prevention,Harbin Medical University,Harbin 150081,People's Republic of China.
authors: Peng
authors: P
authors: Liu
authors: 1Key Lab of Etiology and Epidemiology,Education Bureau of Heilongjiang Province & Ministry of Health,Center for Endemic Disease Control,Chinese Center for Disease Control and Prevention,Harbin Medical University,Harbin 150081,People's Republic of China.
authors: Xiaohui
authors: X
authors: Su
authors: 2Sydney School of Public Health,Sydney Medical School,The University of Sydney,Sydney,2006,Australia.
authors: Mu
authors: M
authors: Li
authors: 1Key Lab of Etiology and Epidemiology,Education Bureau of Heilongjiang Province & Ministry of Health,Center for Endemic Disease Control,Chinese Center for Disease Control and Prevention,Harbin Medical University,Harbin 150081,People's Republic of China.
authors: Hongmei
authors: H
authors: Shen
authors: 1Key Lab of Etiology and Epidemiology,Education Bureau of Heilongjiang Province & Ministry of Health,Center for Endemic Disease Control,Chinese Center for Disease Control and Prevention,Harbin Medical University,Harbin 150081,People's Republic of China.
authors: Jun
authors: J
authors: Yu
authors: 2Sydney School of Public Health,Sydney Medical School,The University of Sydney,Sydney,2006,Australia.
authors: Patrick J
authors: PJ
authors: Kelly
authors: 1Key Lab of Etiology and Epidemiology,Education Bureau of Heilongjiang Province & Ministry of Health,Center for Endemic Disease Control,Chinese Center for Disease Control and Prevention,Harbin Medical University,Harbin 150081,People's Republic of China.
authors: Fangang
authors: F
authors: Meng
authors: 1Key Lab of Etiology and Epidemiology,Education Bureau of Heilongjiang Province & Ministry of Health,Center for Endemic Disease Control,Chinese Center for Disease Control and Prevention,Harbin Medical University,Harbin 150081,People's Republic of China.
authors: Lixiang
authors: 0000-0003-4941-6990
authors: L
authors: Liu
authors: 1Key Lab of Etiology and Epidemiology,Education Bureau of Heilongjiang Province & Ministry of Health,Center for Endemic Disease Control,Chinese Center for Disease Control and Prevention,Harbin Medical University,Harbin 150081,People's Republic of China.
authors: Lijun
authors: L
authors: Fan
authors: 1Key Lab of Etiology and Epidemiology,Education Bureau of Heilongjiang Province & Ministry of Health,Center for Endemic Disease Control,Chinese Center for Disease Control and Prevention,Harbin Medical University,Harbin 150081,People's Republic of China.
authors: Ming
authors: M
authors: Li
authors: 1Key Lab of Etiology and Epidemiology,Education Bureau of Heilongjiang Province & Ministry of Health,Center for Endemic Disease Control,Chinese Center for Disease Control and Prevention,Harbin Medical University,Harbin 150081,People's Republic of China.
authors: Shoujun
authors: S
authors: Liu
authors: 1Key Lab of Etiology and Epidemiology,Education Bureau of Heilongjiang Province & Ministry of Health,Center for Endemic Disease Control,Chinese Center for Disease Control and Prevention,Harbin Medical University,Harbin 150081,People's Republic of China.
authors: Dianjun
authors: D
authors: Sun
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D002681:China; D005260:Female; D006801:Humans; D007455:Iodine / Q000172:deficiency* / Q000652:urine*; D007774:Lactation; D008297:Male; D008875:Middle Aged; D009752:Nutritional Status; D011247:Pregnancy; D012307:Risk Factors; D055815:Young Adult
chemical_list: D007455:Iodine
keywords: Adults; IDD iodine deficiency disorders; Lactating women; MUI median urinary iodine; Median urinary iodine; Pregnant women; SAC school-aged children; School-aged children