title: Plasma protein profiling in a stage defined pancreatic cancer cohort - Implications for early diagnosis.
abstract: Pancreatic ductal adenocarcinoma (PDAC) is a disease where detection preceding clinical symptoms significantly increases the life expectancy of patients. In this study, a recombinant antibody microarray platform was used to analyze 213 Chinese plasma samples from PDAC patients and normal control (NC) individuals. The cohort was stratified according to disease stage, i.e. resectable disease (stage I/II), locally advanced (stage III) and metastatic disease (stage IV). Support vector machine analysis showed that all PDAC stages could be discriminated from controls and that the accuracy increased with disease progression, from stage I to IV. Patients with stage I/II PDAC could be discriminated from NC with high accuracy based on a plasma protein signature, indicating a possibility for early diagnosis and increased detection rate of surgically resectable tumors.
authors: Department of Immunotechnology, CREATE Health Translational Cancer Center, Medicon Village bldg. 406, Lund University, SE 223 81 Lund, Sweden. Electronic address: anna.sandstrom@immun.lth.se.
authors: Anna Sandström
authors: AS
authors: Gerdtsson
authors: Department of Immunotechnology, CREATE Health Translational Cancer Center, Medicon Village bldg. 406, Lund University, SE 223 81 Lund, Sweden. Electronic address: christer.wingren@immun.lth.se.
authors: Christer
authors: C
authors: Wingren
authors: Department of Immunotechnology, CREATE Health Translational Cancer Center, Medicon Village bldg. 406, Lund University, SE 223 81 Lund, Sweden. Electronic address: helena.persson@immun.lth.se.
authors: Helena
authors: H
authors: Persson
authors: Department of Immunotechnology, CREATE Health Translational Cancer Center, Medicon Village bldg. 406, Lund University, SE 223 81 Lund, Sweden. Electronic address: payam.delfani@immun.lth.se.
authors: Payam
authors: P
authors: Delfani
authors: Immunovia AB, Medicon Village, SE 223 81 Lund, Sweden. Electronic address: malin.nordstrom@immunovia.se.
authors: Malin
authors: M
authors: Nordström
authors: Tianjin Medical University Cancer Institute & Hospital, Huan-Hu-Xi Road, Ti-Huan-Bei, He Xi District, Tianjin 300060, PR China. Electronic address: renhe@tjmuch.com.
authors: He
authors: H
authors: Ren
authors: Tianjin Medical University Cancer Institute & Hospital, Huan-Hu-Xi Road, Ti-Huan-Bei, He Xi District, Tianjin 300060, PR China. Electronic address: xinwen8685@163.com.
authors: Xin
authors: X
authors: Wen
authors: Department of Immunotechnology, CREATE Health Translational Cancer Center, Medicon Village bldg. 406, Lund University, SE 223 81 Lund, Sweden. Electronic address: ulrika.ringdahl@skane.se.
authors: Ulrika
authors: U
authors: Ringdahl
authors: Department of Immunotechnology, CREATE Health Translational Cancer Center, Medicon Village bldg. 406, Lund University, SE 223 81 Lund, Sweden. Electronic address: carl.borrebaeck@immun.lth.se.
authors: Carl A K
authors: CA
authors: Borrebaeck
authors: Tianjin Medical University Cancer Institute & Hospital, Huan-Hu-Xi Road, Ti-Huan-Bei, He Xi District, Tianjin 300060, PR China. Electronic address: haojihui@tjmuch.com.
authors: Jihui
authors: J
authors: Hao
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D044466:Asian People; D014408:Biomarkers, Tumor / Q000378:metabolism; D001798:Blood Proteins / Q000378:metabolism*; D016022:Case-Control Studies; D015331:Cohort Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D010190:Pancreatic Neoplasms / Q000097:blood* / Q000175:diagnosis* / Q000473:pathology; D025341:Principal Component Analysis; D040901:Proteomics / Q000379:methods*; D044465:White People; D055815:Young Adult
chemical_list: D014408:Biomarkers, Tumor; D001798:Blood Proteins
keywords: Antibody microarrays; Biomarker signatures; Early detection; Pancreatic cancer; Recombinant antibodies