title: In Vivo Monitoring of Rat Spinal Cord Metabolism Using Hyperpolarized Carbon-13 MR Spectroscopic Imaging.
abstract: This study demonstrated the feasibility of using hyperpolarized13C-MR spectroscopic imaging with [1-13C]-pyruvate to evaluate in vivo spinal cord metabolism. High pyruvate and relatively small lactate signal were observed in the cervical spinal cords of naive rats. Lactate and pyruvate measures were similar for spinal cord and supratentorial brain. The results from this study establish baseline measures for spinal cord hyperpolarized MRS imaging with13C pyruvate. This technique holds promise as a valuable molecular imaging tool for monitoring biochemical processes in the normal and diseased spinal cord.
authors: From the Department of Radiology and Biomedical Imaging (I.P., S.J.N., J.F.T.) ilwoo.park@ucsf.edu.
authors: I
authors: 0000-0001-6022-8363
authors: I
authors: Park
authors: From the Department of Radiology and Biomedical Imaging (I.P., S.J.N., J.F.T.).|Department of Bioengineering and Therapeutic Sciences (S.J.N.).
authors: S J
authors: 0000-0001-8015-5157
authors: SJ
authors: Nelson
authors: From the Department of Radiology and Biomedical Imaging (I.P., S.J.N., J.F.T.).|Brain and Spinal Injury Center (BASIC), San Francisco General Hospital (J.F.T.), University of California, San Francisco, San Francisco, California.
authors: J F
authors: 0000-0003-3943-5530
authors: JF
authors: Talbott
mesh_terms: D000818:Animals; D002247:Carbon Isotopes; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D019289:Pyruvic Acid / Q000378:metabolism; D051381:Rats; D013116:Spinal Cord / Q000378:metabolism*
chemical_list: D002247:Carbon Isotopes; D019289:Pyruvic Acid; C000615229:Carbon-13