title: Polysaccharide based nanogels in the drug delivery system: Application as the carrier of pharmaceutical agents.
abstract: Polysaccharide-based nanoparticles have fascinated attention as a vesicle of different pharmaceutical agents due to their unique multi-functional groups in addition to their physicochemical properties, including biocompatibility and biodegradability. The existence of multi-functional groups on the polysaccharide backbone permits facile chemical or biochemical modification to synthesize polysaccharide based nanoparticles with miscellaneous structures. Polysaccharide-based nanogels have high water content, large surface area for multivalent bioconjugation, tunable size, and interior network for the incorporation of different pharmaceutical agents. These unique properties offer great potential for the utilization of polysaccharide-based nanogels in the drug delivery systems. Hence, this review describes chemistry of certain common polysaccharides, several methodologies used to synthesize polysaccharide nanoparticles and primarily focused on the polysaccharide (or polysaccharide derivative) based nanogels as the carrier of pharmaceutical agents.
authors: Graduate Institute of Applied Science and Technology, National Taiwan University of Science and Technology, postcode 106 Taipei, Taiwan.
authors: Tilahun Ayane
authors: TA
authors: Debele
authors: Graduate Institute of Applied Science and Technology, National Taiwan University of Science and Technology, postcode 106 Taipei, Taiwan.
authors: Shewaye Lakew
authors: SL
authors: Mekuria
authors: Graduate Institute of Applied Science and Technology, National Taiwan University of Science and Technology, postcode 106 Taipei, Taiwan. Electronic address: h.c.tsai@mail.ntust.edu.tw.
authors: Hsieh-Chih
authors: HC
authors: Tsai
mesh_terms: D004337:Drug Carriers / Q000737:chemistry / Q000627:therapeutic use; D005782:Gels; D053758:Nanoparticles / Q000737:chemistry*; D011134:Polysaccharides / Q000737:chemistry / Q000627:therapeutic use
chemical_list: D004337:Drug Carriers; D005782:Gels; D011134:Polysaccharides
keywords: Cancer; Drug delivery systems; Nanogels; Nanoparticles; Polysaccharide