title: Stability of furosemide polymorphs and the effects of complex formation with β-cyclodextrin and maltodextrin.
abstract: The effect of the formation of supramolecular binary complexes with β-cyclodextrin and maltodextrin on the chemical and physical stability of the polymorphs I and II of furosemide was evaluated in solid state. The solid samples were placed under accelerated storage conditions and exposed to daylight into a stability chamber for a 6-month. Chemical stability was monitored by high performance liquid chromatography, while the physical stability was studied by solid state nuclear magnetic resonance, powder X-ray diffraction and scanning electron microscopy. Changes in the physical appearance of the samples were evaluated. The studies showed a significant stabilizing effect of β-cyclodextrin on furosemide form II. Our results suggest that the complex formation is a useful tool for improving the stability of furosemide polymorphs. These new complexes are promising candidates that can be used in the pharmaceutical industry for the preparation of alternative matrices that improve physicochemical properties.
authors: Unidad de Investigación y Desarrollo en Tecnología Farmacéutica (UNITEFA), CONICET-UNC and Departamento de Farmacia, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Ciudad Universitaria, X5000HUA Córdoba, Argentina. Electronic address: garneroc@fcq.unc.edu.ar.
authors: Claudia
authors: C
authors: Garnero
authors: Facultad de Matemática, Astronomía y Física and IFEG (CONICET), Universidad Nacional de Córdoba, Ciudad Universitaria, X5000HUA Córdoba, Argentina. Electronic address: chattah@famaf.unc.edu.ar.
authors: Ana Karina
authors: AK
authors: Chattah
authors: Unidad de Investigación y Desarrollo en Tecnología Farmacéutica (UNITEFA), CONICET-UNC and Departamento de Farmacia, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Ciudad Universitaria, X5000HUA Córdoba, Argentina. Electronic address: mrlcor@fcq.unc.edu.ar.
authors: Marcela
authors: M
authors: Longhi
mesh_terms: D004355:Drug Stability; D005665:Furosemide / Q000737:chemistry*; D011134:Polysaccharides / Q000737:chemistry*; D047392:beta-Cyclodextrins / Q000737:chemistry*
chemical_list: D011134:Polysaccharides; D047392:beta-Cyclodextrins; C008315:maltodextrin; D005665:Furosemide; C031215:betadex
keywords: Cyclodextrin; Furosemide; Maltodextrin; Polymorphism; Solid state NMR; Stability