title: Pharmacogenetics and Personalized Medicine in Pain Management.
abstract: Genetic research heralds a new therapeutic approach to pain management. Increasing literature demonstrates individual genetic vulnerabilities to specific pain types and mechanisms, partially explaining differing responses to similar pain stimuli. Furthermore, analgesics demonstrate great variability among carriers of different genotypes. Family history and genotyping promise to play an important role in the future approach to pain therapies. As advances continue in the genetics of pain and analgesia, pharmacotherapy will depend more on an individualized, targeted approach and less on empiricism.
authors: Scientific Affairs, PRA Health Sciences, 3838 South 700 East, Suite 202, Salt Lake City, UT 84106, USA. Electronic address: lrwebstermd@gmail.com.
authors: Lynn R
authors: LR
authors: Webster
authors: Department of Medicine, University of Pittsburgh, 3550 Terrace Street, Pittsburgh, PA 15261, USA; Department of Human Genetics, University of Pittsburgh, Pittsburgh, PA, USA.
authors: Inna
authors: I
authors: Belfer
mesh_terms: D000700:Analgesics / Q000627:therapeutic use*; D005838:Genotype; D006801:Humans; D010146:Pain / Q000188:drug therapy* / Q000235:genetics*; D010597:Pharmacogenetics; D000071184:Pharmacogenomic Variants; D057285:Precision Medicine
chemical_list: D000700:Analgesics
keywords: Cytochrome P450 (CYP); Genomic testing; Pain management; Pharmacogenetics; Polymorphism