title: Colonic Macrophages "Remote Control" Adipose Tissue Inflammation and Insulin Resistance.
abstract: The early events linking diet-induced adipose tissue inflammation and insulin resistance remain poorly understood. In this issue of Cell Metabolism, Kawano et al. (2016) show that infiltration of colonic pro-inflammatory macrophages orchestrated by the intestinal CCL2/CCR2 axis kick-starts this process during high-fat-diet feeding.
authors: Singapore Immunology Network (SIgN), Agency for Science, Technology, and Research (A(∗)STAR), #04-06 Immunos, 8A Biomedical Grove, Singapore 138648, Singapore. Electronic address: subhra_biswas@immunol.a-star.edu.sg.
authors: Subhra K
authors: SK
authors: Biswas
authors: Humanitas Clinical and Research Center, Rozzano 20089, Italy; Department of Biomedical Sciences, Humanitas University, Rozzano 20089, Italy. Electronic address: raffaella.bonecchi@humanitasresearch.it.
authors: Raffaella
authors: R
authors: Bonecchi
mesh_terms: D000273:Adipose Tissue; D006801:Humans; D007249:Inflammation; D007333:Insulin Resistance; D008264:Macrophages; D008810:Mice, Inbred C57BL; D009765:Obesity