title: A case of lithium-induced parkinsonism presenting with typical motor symptoms of Parkinson's disease in a bipolar patient.
abstract: Lithium is a mood stabilizer rarely associated with drug-induced parkinsonism (DIP). We present a case of an elderly woman with bipolar disorder who developed parkinsonian symptoms after chronic lithium administration despite therapeutic serum levels. Upon evaluation, classic parkinsonian signs of muscle rigidity, tremor, bradykinesia, freezing of gait, and cognitive decline were observed. Initially, she was diagnosed with Parkinson's disease (PD); however, DaTscan SPECT imaging clarified the diagnosis as DIP. As the daily lithium dosage was reduced, the patient's motor symptoms improved. This report emphasizes close monitoring of lithium levels in geriatric populations and the need to consider lithium-induced parkinsonism when PD symptoms appear in chronic lithium users.
authors: Department of Psychiatry and Behavioral Sciences,Emory University School of Medicine,Atlanta,Georgia,USA.
authors: Adriana P
authors: AP
authors: Hermida
authors: Department of Psychiatry and Behavioral Sciences,Emory University School of Medicine,Atlanta,Georgia,USA.
authors: A Umair
authors: AU
authors: Janjua
authors: Department of Psychiatry and Behavioral Medicine,East Carolina University,Greenville,North Carolina,USA.
authors: Oliver M
authors: OM
authors: Glass
authors: Department of Medicine,Emory University School of Medicine,Atlanta,Georgia,USA.
authors: Camille P
authors: CP
authors: Vaughan
authors: Department of Neurology,Emory University School of Medicine,Atlanta,Georgia,USA.
authors: Felicia
authors: F
authors: Goldstein
authors: Department of Neurology,Emory University School of Medicine,Atlanta,Georgia,USA.
authors: Lynn Marie
authors: LM
authors: Trotti
authors: Department of Neurology,Emory University School of Medicine,Atlanta,Georgia,USA.
authors: Stewart A
authors: SA
authors: Factor
mesh_terms: D000368:Aged; D001714:Bipolar Disorder / Q000188:drug therapy*; D004305:Dose-Response Relationship, Drug; D016903:Drug Monitoring / Q000379:methods; D005260:Female; D006801:Humans; D018020:Lithium Compounds / Q000008:administration & dosage / Q000009:adverse effects / Q000097:blood; D009460:Neurologic Examination / Q000379:methods; D010302:Parkinson Disease, Secondary / Q000139:chemically induced / Q000175:diagnosis / Q000628:therapy; D011619:Psychotropic Drugs / Q000008:administration & dosage / Q000009:adverse effects / Q000097:blood; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods; D016896:Treatment Outcome
chemical_list: D018020:Lithium Compounds; D011619:Psychotropic Drugs
keywords: Parkinson's disease; bipolar disorder; comprehensive care; drug-induced parkinsonism; geriatrics; lithium