title: Pre-germinated brown rice prevented high fat diet induced hyperlipidemia through ameliorating lipid synthesis and metabolism in C57BL/6J mice.
abstract: Pre-germinated brown rice (PGBR) can ameliorate hyperlipidemia, but the action mechanism is not clear. We focus the mechanisms of PGBR prevented hyperlipidemia. Six-week-old mice were divided into: standard-regular diet (SRD), high-fat diet (HFD) and HFD with PGBR (HFD + PGBR) groups for 16 weeks. The HFD group has higher concentrations of TG, TC, HDL and Non-HDL in the blood, and a higher atherosclerosis index (AI). The TG levels in the liver, and TG, bile acid levels in the feces were enhanced; and the total adipocytokines level in adipose tissue was reduced. The HFD group had higher protein expressions of SREBP-1, SCD-1, FAS, LDLR, and CYP7α1 in the liver. Moreover, the greater expressions of SREBP-1, SCD-1, FAS and the less expressions of PPAR-α and adiponectin were in adipose tissue. In the HFD + PGBR group, the PGBR regulated the levels of TG, TC, HDL, Non-HDL, AI and adipocytokines. PGBR increased more cholesterol and bile acid exhaust in feces. The SREBP-1, SCD-1, FAS, HMGCR, LDLR, CYP7α1 and PPAR-α proteins in the liver; and the SREBP-1, SCD-1, FAS, PPAR-α and adiponectin proteins in adipose tissue were reversed by PGBR. Taken together, PGBR can improve lipid synthesis and metabolism, and we suggest PGBR is a recommendable food for controlling hyperlipidemia.
authors: Department of Nursing, Meiho University, Pingtung 91202, Taiwan.
authors: Kuo-Ping
authors: KP
authors: Shen
authors: Division of Cardiology, Department of Internal Medicine, Pingtung Christian Hospital, Pingtung 90053, Taiwan.
authors: Chi-Long
authors: CL
authors: Hao
authors: Division of Cardiology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung 80708, Taiwan.
authors: Hsueh-Wei
authors: HW
authors: Yen
authors: MS program for Applied Health and Biotechnology, Meiho University, Pingtung 91202, Taiwan.
authors: Chun-Yen
authors: CY
authors: Chen
authors: MS program for Applied Health and Biotechnology, Meiho University, Pingtung 91202, Taiwan.
authors: Jia-Hao
authors: JH
authors: Chen
authors: Department of Chemistry, National Cheng-Kung University, Tainan 70101, Taiwan.
authors: Fu-Chih
authors: FC
authors: Chen
authors: Department of Food Science and Nutrition, Meiho University, Pingtung 91202, Taiwan.
authors: Hui-Li
authors: HL
authors: Lin
keywords: hyperlipidemia; lipid synthesis and metabolism; pre-germinated brown rice