title: Postantifungal effect of caspofungin against the Candida albicans and Candida parapsilosis clades.
abstract: Killing and postantifungal effects could be relevant for the selection of optimal dosing schedules. This study aims to compare time-kill and postantifungal effects with caspofungin on Candida albicans (C. albicans, Candida dubliniensis, Candida africana) and Candida parapsilosis (C. parapsilosis, Candida metapsilosis, Candida orthopsilosis) clades. In the postantifungal effect experiments, strains were exposed to caspofungin for 1 h at concentrations 0.12-8 μg/mL. Time-kill experiments were conducted at the same concentrations. Caspofungin exhibited a significant and prolonged postantifungal effect (>37 h) with 2 μg/mL against the most strains of C. albicans clade. Against the C. parapsilosis clade, the postantifungal effect was <12 h at 8 μg/mL, except for two strains. Caspofungin was fungicidal against C. albicans, C. dubliniensis and C. metapsilosis.
authors: Departamento de Inmunología, Microbiología y Parasitología, Facultad de Medicina y Enfermería, Universidad del País Vasco/Euskal Herriko Unibertsitatea, Bilbao, Spain; Departamento de Farmacología, Unidad de formación e investigación multidisciplinar "Microbios y Salud" (UFI 11/25), Facultad de Medicina y Enfermería, Universidad del País Vasco/Euskal Herriko Unibertsitatea, Bilbao, Spain. Electronic address: sandra.gil@ehu.eus.
authors: Sandra
authors: S
authors: Gil-Alonso
authors: Departamento de Farmacología, Unidad de formación e investigación multidisciplinar "Microbios y Salud" (UFI 11/25), Facultad de Medicina y Enfermería, Universidad del País Vasco/Euskal Herriko Unibertsitatea, Bilbao, Spain. Electronic address: nerea.jauregizar@ehu.eus.
authors: Nerea
authors: N
authors: Jauregizar
authors: Departamento de Inmunología, Microbiología y Parasitología, Facultad de Medicina y Enfermería, Universidad del País Vasco/Euskal Herriko Unibertsitatea, Bilbao, Spain. Electronic address: elena.eraso@ehu.eus.
authors: Elena
authors: E
authors: Eraso
authors: Departamento de Inmunología, Microbiología y Parasitología, Facultad de Medicina y Enfermería, Universidad del País Vasco/Euskal Herriko Unibertsitatea, Bilbao, Spain. Electronic address: guillermo.quindos@ehu.eus.
authors: Guillermo
authors: G
authors: Quindós
mesh_terms: D000935:Antifungal Agents / Q000494:pharmacology*; D002175:Candida / Q000187:drug effects* / Q000502:physiology; D000077336:Caspofungin; D054714:Echinocandins / Q000494:pharmacology*; D006801:Humans; D055666:Lipopeptides / Q000494:pharmacology*; D050296:Microbial Viability / Q000187:drug effects; D013997:Time Factors
chemical_list: D000935:Antifungal Agents; D054714:Echinocandins; D055666:Lipopeptides; D000077336:Caspofungin
keywords: Candida africana; Candida albicans; Candida dubliniensis; Candida metapsilosis; Candida orthopsilosis; Candida parapsilosis; Caspofungin; Echinocandins; Postantifungal effect