title: A Prospective Multicenter Randomized Controlled Study on Interleukin-6 Removal and Induction by a new Hemodialyzer With Improved Biocompatibility in Hemodialysis Patients: A Pilot Study.
abstract: We compared interleukin-6 (IL-6) removal and induction between conventional polysulfone (Con) and TORAYLIGHT NV (NV) dialyzers in hemodialysis patients. Twenty patients on Con with high IL-6 concentrations (2.7-8.5 pg/mL) were randomized to Con or NV group. Dialyzer performance was determined in NV group while patients were on Con and after being switched onto NV. Erythropoiesis-stimulating agent (ESA) response index (ERI) was assessed every 4 months for one year. IL-6 clearance was comparable between Con and NV. IL-6 removal rates were comparable for the first 1 h, but were higher with NV for the entire session (P = 0.03). Before-to-during-dialysis IL-6 concentration ratios were lower with NV on the venous side after the session (P = 0.03). During the one-year study, hemoglobin was lower in Con group than in NV group at month 8 (P = 0.046). ERI decreased in NV and increased in Con group, with a significant difference between the groups (P = 0.002). NV and Con are comparable in removing IL-6 and both induce IL-6. However, the data suggest that NV induces less IL-6, which may reduce the risk of ESA hyporesponsiveness.
authors: Division of Nephrology, Endocrinology and Metabolism, Department of Medicine, Tokai University Hachioji Hospital, Hachioji, Tokyo, Japan.|Division of Nephrology, Endocrinology and Metabolism, Department of Medicine, Tokai University School of Medicine, Isehara, Kanagawa, Japan.
authors: Takatoshi
authors: T
authors: Kakuta
authors: Division of Nephrology, Endocrinology and Metabolism, Department of Medicine, Tokai University School of Medicine, Isehara, Kanagawa, Japan.
authors: Hirotaka
authors: http://orcid.org/0000-0002-1704-4507
authors: H
authors: Komaba
authors: Bohsei-Kannai Clinic, Yokohama, Kanagawa, Japan.
authors: Nobuyoshi
authors: N
authors: Takagi
authors: Jinken Clinic, Ebina, Kanagawa, Japan.
authors: Yuichiro
authors: Y
authors: Takahashi
authors: Division of Nephrology, Endocrinology and Metabolism, Department of Medicine, Tokai University School of Medicine, Isehara, Kanagawa, Japan.
authors: Hajime
authors: H
authors: Suzuki
authors: Eijin Clinic, Hiratsuka, Kanagawa, Japan.
authors: Toru
authors: T
authors: Hyodo
authors: Hon-atsugi Medical Clinic, Atsugi, Kanagawa, Japan.
authors: Mikako
authors: M
authors: Nagaoka
authors: Bohsei-Ohone Clinic, Hadano, Japan.
authors: Reika
authors: R
authors: Tanaka
authors: Chigasaki Central Clinic, Chigasaki, Kanagawa, Japan.
authors: Soichiro
authors: S
authors: Iwao
authors: Division of Nephrology, Endocrinology and Metabolism, Department of Medicine, Tokai University Hachioji Hospital, Hachioji, Tokyo, Japan.
authors: Mari
authors: M
authors: Ishida
authors: Department of Clinical Pharmacology, Tokai University School of Medicine, Kanagawa, Japan.
authors: Hiroyuki
authors: H
authors: Kobayashi
authors: Tokai University School of Medicine, Isehara, Kanagawa, Japan.
authors: Akira
authors: A
authors: Saito
authors: Division of Nephrology, Endocrinology and Metabolism, Department of Medicine, Tokai University School of Medicine, Isehara, Kanagawa, Japan.
authors: Masafumi
authors: M
authors: Fukagawa
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D015850:Interleukin-6; D007676:Kidney Failure, Chronic / Q000628:therapy*; D007688:Kidneys, Artificial; D008297:Male; D008875:Middle Aged; D010865:Pilot Projects; D011108:Polymers; D011446:Prospective Studies; D006435:Renal Dialysis / Q000379:methods*; D013450:Sulfones; D016896:Treatment Outcome
chemical_list: D015850:Interleukin-6; D011108:Polymers; D013450:Sulfones; C017662:polysulfone P 1700
keywords: Biocompatibility; Erythropoiesis stimulating agent; Hemodialysis; Inflammatory cytokine