title: The cellular basis of dendrite pathology in neurodegenerative diseases.
abstract: One of the characteristics of the neurons that distinguishes them from other cells is their complex and polarized structure consisting of dendrites, cell body, and axon. The complexity and diversity of dendrites are particularly well recognized, and accumulating evidences suggest that the alterations in the dendrite structure are associated with many neurodegenerative diseases. Given the importance of the proper dendritic structures for neuronal functions, the dendrite pathology appears to have crucial contribution to the pathogenesis of neurodegenerative diseases. Nonetheless, the cellular and molecular basis of dendritic changes in the neurodegenerative diseases remains largely elusive. Previous studies in normal condition have revealed that several cellular components, such as local cytoskeletal structures and organelles located locally in dendrites, play crucial roles in dendrite growth. By reviewing what has been unveiled to date regarding dendrite growth in terms of these local cellular components, we aim to provide an insight to categorize the potential cellular basis that can be applied to the dendrite pathology manifested in many neurodegenerative diseases. [BMB Reports 2017; 50(1): 5-11].
authors: Department of Brain & Cognitive Sciences, DGIST, Daegu 42988, Korea.
authors: Jung Hyun
authors: JH
authors: Kweon
authors: Disease Target Structure Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon 34141; Department of Biomolecular Science, University of Science and Technology, Daejeon 34141, Korea.
authors: Sunhong
authors: S
authors: Kim
authors: Department of Brain & Cognitive Sciences, DGIST, Daegu 42988, Korea.
authors: Sung Bae
authors: SB
authors: Lee
mesh_terms: D000818:Animals; D001369:Axons / Q000473:pathology; D003712:Dendrites / Q000473:pathology*; D006801:Humans; D019636:Neurodegenerative Diseases / Q000473:pathology*; D009474:Neurons / Q000473:pathology*