title: Comparison of Respiratory Outcomes between Preterm Small-For-Gestational-Age and Appropriate-For-Gestational-Age Infants.
abstract: ObjectiveThis study aims to determine whether preterm infants who are small for gestational age (SGA) are more likely to have respiratory distress syndrome (RDS) compared with appropriate-for-gestational-age infants.MethodsSecondary analysis of a multicenter trial evaluating magnesium for neuroprotection. Nonanomalous, singleton gestations delivered between 220/7and 366/7weeks were included. Large-for-gestational-age infants were excluded. We performed a nested case-control study. Cases were infants with RDS; controls were infants without RDS. The sample size estimates revealed 779 subjects/group were needed to achieve a 80% power to demonstrate a 1/3 difference in RDS. We fit a multivariable logistic regression model to adjust for confounders. We assessed the association of SGA with RDS and a composite adverse respiratory and neonatal outcome.ResultsOverall, 947 cases and 920 controls were included. The groups differed by gestational age at delivery, antibiotic exposure, mode of delivery, infant gender, and birth weight. SGA was not associated with RDS (adjusted odds ratio [aOR]: 1.07, 95% confidence interval [CI]: 0.48-2.38) or the composite respiratory (aOR: 0.87, 95% CI: 0.37-2.04) or adverse neonatal outcome (aOR: 0.65, 95% CI: 0.27-1.54). RDS and the composite respiratory outcome were most associated with earlier gestational age at delivery, cesarean delivery, and male gender.ConclusionSGA is not associated with RDS or other adverse respiratory and neonatal composites.
authors: Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, Columbia University Medical Center, New York, New York.
authors: Amy L
authors: AL
authors: Turitz
authors: Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, Columbia University Medical Center, New York, New York.
authors: Cynthia
authors: C
authors: Gyamfi-Bannerman
mesh_terms: D001724:Birth Weight; D001997:Bronchopulmonary Dysplasia / Q000453:epidemiology; D016022:Case-Control Studies; D000074042:Cerebral Intraventricular Hemorrhage / Q000453:epidemiology; D002585:Cesarean Section; D020345:Enterocolitis, Necrotizing / Q000453:epidemiology; D005260:Female; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D007236:Infant, Small for Gestational Age; D008297:Male; D066087:Perinatal Death; D047928:Premature Birth; D016032:Randomized Controlled Trials as Topic; D012121:Respiration, Artificial; D012127:Respiratory Distress Syndrome, Newborn / Q000453:epidemiology*; D012307:Risk Factors; D012640:Seizures / Q000453:epidemiology; D018805:Sepsis / Q000453:epidemiology; D012737:Sex Factors; D059245:Transient Tachypnea of the Newborn / Q000453:epidemiology