title: Wolf-Hirschhorn (4p-) syndrome with West syndrome.
abstract: Wolf-Hirschhorn syndrome (WHS) is a chromosome disorder (4p-syndrome) which is characterized by craniofacial features and epileptic seizures. Here, we report a case of WHS with West syndrome, in whom the seizures were refractory to several antiepileptic drugs but were responsive to the addition of lamotrigine. The patient had epileptic spasms at age seven months. The interictal electroencephalogram was hypsarrhythmic. After adding lamotrigine, seizures decreased remarkably, and spasms disappeared. We have identified and described the very rare case of a girl with WHS who also developed West syndrome. In this case, adding lamotrigine to her medications effectively treated the spasms.
authors: Department of Child Neurology, Comprehensive Epilepsy Center, Seirei-Hamamatsu General Hospital, Hamamatsu, Shizuoka, Japan.
authors: Hirotaka
authors: H
authors: Motoi
authors: Department of Child Neurology, Comprehensive Epilepsy Center, Seirei-Hamamatsu General Hospital, Hamamatsu, Shizuoka, Japan.
authors: Tohru
authors: T
authors: Okanishi
authors: Department of Child Neurology, Comprehensive Epilepsy Center, Seirei-Hamamatsu General Hospital, Hamamatsu, Shizuoka, Japan.
authors: Sotaro
authors: S
authors: Kanai
authors: Department of Child Neurology, Comprehensive Epilepsy Center, Seirei-Hamamatsu General Hospital, Hamamatsu, Shizuoka, Japan.
authors: Takuya
authors: T
authors: Yokota
authors: Department of Epilepsy Surgery, Comprehensive Epilepsy Center, Seirei-Hamamatsu General Hospital, Hamamatsu, Shizuoka, Japan.
authors: Tomohiro
authors: T
authors: Yamazoe
authors: Laboratory of Neurophysiology, Seirei-Hamamatsu General Hospital, Hamamatsu, Shizuoka, Japan.
authors: Mitsuyo
authors: M
authors: Nishimura
authors: Department of Epilepsy Surgery, Comprehensive Epilepsy Center, Seirei-Hamamatsu General Hospital, Hamamatsu, Shizuoka, Japan.
authors: Ayataka
authors: A
authors: Fujimoto
authors: Department of Epilepsy Surgery, Comprehensive Epilepsy Center, Seirei-Hamamatsu General Hospital, Hamamatsu, Shizuoka, Japan.
authors: Takamichi
authors: T
authors: Yamamoto
authors: Department of Child Neurology, Comprehensive Epilepsy Center, Seirei-Hamamatsu General Hospital, Hamamatsu, Shizuoka, Japan.
authors: Hideo
authors: H
authors: Enoki
keywords: Epilepsy; Lamotrigine; Spasm; West syndrome; Wolf–Hirschhorn syndrome