title: Disinhibition-like behavior in a P301S mutant tau transgenic mouse model of frontotemporal dementia.
abstract: Frontotemporal dementia (FTD) presents clinically with behavioral changes including disinhibition. Mutations in the tau-encoding MAPT gene identified in familial cases of FTD have been used to generate transgenic mouse models of the human condition. Here, we report behavioral changes in a recently developed P301S mutant tau transgenic mouse, including disinhibition-like behavior in the elevated plus maze and hyperactivity in the open field arena. Furthermore, histological analysis revealed the amygdala as a primary and early site of pathological tau deposition in these mice. Taken together, neuropathological and behavioral changes in P301S tau transgenic mice resemble features of human FTD.
authors: Dementia Research Unit, Department of Anatomy, School of Medical Sciences, Faculty of Medicine, University of New South Wales, Sydney, NSW, Australia.
authors: Magdalena
authors: M
authors: Przybyla
authors: Dementia Research Unit, Department of Anatomy, School of Medical Sciences, Faculty of Medicine, University of New South Wales, Sydney, NSW, Australia.
authors: Claire H
authors: CH
authors: Stevens
authors: Dementia Research Unit, Department of Anatomy, School of Medical Sciences, Faculty of Medicine, University of New South Wales, Sydney, NSW, Australia.
authors: Julia
authors: J
authors: van der Hoven
authors: Dementia Research Unit, Department of Anatomy, School of Medical Sciences, Faculty of Medicine, University of New South Wales, Sydney, NSW, Australia.
authors: Anne
authors: A
authors: Harasta
authors: Dementia Research Unit, Department of Anatomy, School of Medical Sciences, Faculty of Medicine, University of New South Wales, Sydney, NSW, Australia.
authors: Mian
authors: M
authors: Bi
authors: Dementia Research Unit, Department of Anatomy, School of Medical Sciences, Faculty of Medicine, University of New South Wales, Sydney, NSW, Australia.
authors: Arne
authors: A
authors: Ittner
authors: Dementia Research Unit, Department of Anatomy, School of Medical Sciences, Faculty of Medicine, University of New South Wales, Sydney, NSW, Australia.
authors: Annika
authors: A
authors: van Hummel
authors: Neuroscience Research Australia, Sydney, NSW, Australia.
authors: John R
authors: JR
authors: Hodges
authors: Neuroscience Research Australia, Sydney, NSW, Australia; ARC Centre of Excellence in Cognition and its Disorders, Sydney, NSW, Australia.
authors: Olivier
authors: O
authors: Piguet
authors: Neuroscience Research Australia, Sydney, NSW, Australia; School of Medicine, Western Sydney University, Campbelltown, NSW, Australia.
authors: Tim
authors: T
authors: Karl
authors: School of Chemistry and Faculty of health Sciences, University of Sydney, Sydney, NSW, Australia.
authors: Michael
authors: M
authors: Kassiou
authors: Translational Neuroscience Facility, Department of Physiology, School of Medical Sciences, Faculty of Medicine, University of New South Wales, Sydney, NSW, Australia.
authors: Gary D
authors: GD
authors: Housley
authors: Motor Neuron Disease Unit, Department of Anatomy, School of Medical Sciences, Faculty of Medicine, University of New South Wales, Sydney, NSW, Australia.
authors: Yazi D
authors: YD
authors: Ke
authors: Dementia Research Unit, Department of Anatomy, School of Medical Sciences, Faculty of Medicine, University of New South Wales, Sydney, NSW, Australia; Neuroscience Research Australia, Sydney, NSW, Australia; Transgenic Animal Unit, Mark Wainright Analytical Centre, University of New South Wales, Sydney, NSW, Australia. Electronic address: l.ittner@unsw.edu.au.
authors: Lars M
authors: LM
authors: Ittner
authors: Dementia Research Unit, Department of Anatomy, School of Medical Sciences, Faculty of Medicine, University of New South Wales, Sydney, NSW, Australia.
authors: Janet
authors: J
authors: van Eersel
mesh_terms: D000679:Amygdala / Q000378:metabolism; D000818:Animals; D001007:Anxiety / Q000235:genetics; D001522:Behavior, Animal / Q000502:physiology*; D004195:Disease Models, Animal; D057180:Frontotemporal Dementia / Q000235:genetics* / Q000523:psychology*; D006801:Humans; D006948:Hyperkinesis / Q000235:genetics; D008297:Male; D051379:Mice; D008822:Mice, Transgenic; D009043:Motor Activity; D009154:Mutation; D016875:tau Proteins / Q000235:genetics* / Q000378:metabolism
chemical_list: C054369:MAPT protein, human; D016875:tau Proteins
keywords: Behavior; Frontotemporal dementia; Tau; Transgenic mouse model