title: A 12-year prognosis of adult-onset asthma: Seinäjoki Adult Asthma Study.
abstract: Long-term prognosis of adult-onset asthma is poorly known.
  
  
  
  To evaluate 12-year prognosis of adult-onset asthma and the factors associated with disease prognosis.
  
  
  
  Seinäjoki Adult-onset Asthma Study (SAAS) is a 12-year real-life single-center follow-up study of new-onset asthma diagnosed at adult age and treated in primary and specialized care. Remission was defined by no symptoms and no asthma medication use for 6 months. Asthma control was evaluated according to Global Initiative for Asthma 2010. Factors associated with current asthma control were analyzed by multinomial multivariate logistic regression.
  
  
  
  A total of 203 patients (79% of the baseline population) were followed for 12 years. Remission occurred in 6 (3%) patients. In 34% asthma was controlled, in 36% it was partially controlled and in 30% uncontrolled. Uncontrolled asthma was predicted by elevated body-mass index at baseline, smoking (pack-years) and current allergic or persistent rhinitis. Elevated blood eosinophils and good lung function (FEV1) at baseline protected from uncontrolled asthma. In contrast, gender, age at the onset or baseline symptoms (Airways Questionnaire 20) were not significant predictors of uncontrolled disease.
  
  
  
  During a 12-year follow-up, remission of adult-onset asthma was rare occurring in only 3% of patients. The majority of patients (66%) presented either with uncontrolled or partially controlled asthma. This study is registered at ClinicalTrials.gov with identifier number NCT02733016.
authors: Department of Respiratory Medicine, Seinäjoki Central Hospital, Seinäjoki, Finland. Electronic address: leena.tuomisto@epshp.fi.
authors: Leena E
authors: LE
authors: Tuomisto
authors: Department of Respiratory Medicine, Seinäjoki Central Hospital, Seinäjoki, Finland.
authors: Pinja
authors: P
authors: Ilmarinen
authors: Department of Laboratory Medicine and Medical Research Unit, Seinäjoki Central Hospital and University of Tampere, Finland.
authors: Onni
authors: O
authors: Niemelä
authors: Department of Clinical Physiology, Seinäjoki Central Hospital, Seinäjoki, Finland.
authors: Jussi
authors: J
authors: Haanpää
authors: Police University College, Tampere, Finland.
authors: Terhi
authors: T
authors: Kankaanranta
authors: Department of Respiratory Medicine, Seinäjoki Central Hospital, Seinäjoki, Finland; Department of Respiratory Medicine, University of Tampere, Tampere, Finland.
authors: Hannu
authors: H
authors: Kankaanranta
mesh_terms: D000328:Adult; D017668:Age of Onset; D000368:Aged; D018927:Anti-Asthmatic Agents / Q000627:therapeutic use; D001249:Asthma / Q000175:diagnosis* / Q000188:drug therapy / Q000453:epidemiology; D004804:Eosinophils / Q000166:cytology / Q000502:physiology; D005260:Female; D005500:Follow-Up Studies; D005541:Forced Expiratory Volume / Q000502:physiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012075:Remission, Spontaneous; D012220:Rhinitis / Q000453:epidemiology; D012720:Severity of Illness Index; D012907:Smoking / Q000453:epidemiology
chemical_list: D018927:Anti-Asthmatic Agents
keywords: Adult; Asthma; Control; Eosinophils; Follow-up; Remission