title: Preclinical acute toxicity, biodistribution, pharmacokinetics, radiation dosimetry and microPET imaging studies of [(18)F]fluorocholine in mice.
abstract: [(18)F]Fluorocholine ([(18)F]FCH) has been proven to be effective in prostate cancer. Since [(18)F]FCH is classified as a new radiopharmaceutical in Brazil, preclinical safety and efficacy data are required to support clinical trials and to obtain its approval. The aim of this work was to perform acute toxicity, biodistribution, pharmacokinetics, radiation dosimetry and microPET imaging studies of [(18)F]FCH. The results could support its use in nuclear medicine as an important piece of work for regulatory in Brazil.
authors: Radiopharmaceutical Production and Development Unit, Nuclear Technology Development Center (CDTN), Belo Horizonte, M.G., Brazil. Electronic address: marinabic@yahoo.com.br.
authors: Marina B
authors: MB
authors: Silveira
authors: Radiopharmaceutical Production and Development Unit, Nuclear Technology Development Center (CDTN), Belo Horizonte, M.G., Brazil.
authors: Soraya M Z M D
authors: SM
authors: Ferreira
authors: Radiopharmaceutical Production and Development Unit, Nuclear Technology Development Center (CDTN), Belo Horizonte, M.G., Brazil.
authors: Leonardo T C
authors: LT
authors: Nascimento
authors: Radiopharmaceutical Production and Development Unit, Nuclear Technology Development Center (CDTN), Belo Horizonte, M.G., Brazil.
authors: Flávia M
authors: FM
authors: Costa
authors: Radiopharmaceutical Production and Development Unit, Nuclear Technology Development Center (CDTN), Belo Horizonte, M.G., Brazil.
authors: Bruno M
authors: BM
authors: Mendes
authors: Radiopharmaceutical Production and Development Unit, Nuclear Technology Development Center (CDTN), Belo Horizonte, M.G., Brazil.
authors: Andrea V
authors: AV
authors: Ferreira
authors: Radiopharmaceutical Production and Development Unit, Nuclear Technology Development Center (CDTN), Belo Horizonte, M.G., Brazil.
authors: Carlos
authors: C
authors: Malamut
authors: Radiopharmaceutical Production and Development Unit, Nuclear Technology Development Center (CDTN), Belo Horizonte, M.G., Brazil.
authors: Juliana B
authors: JB
authors: Silva
authors: Anatomy and Imaging Department, Faculty of Medicine, Federal University of Minas Gerais, Belo Horizonte, M.G., Brazil.
authors: Marcelo
authors: M
authors: Mamede
mesh_terms: D065638:Absorption, Radiation; D000818:Animals; D002794:Choline / Q000031:analogs & derivatives* / Q000493:pharmacokinetics / Q000633:toxicity; D004353:Drug Evaluation, Preclinical; D006801:Humans; D008297:Male; D008657:Metabolic Clearance Rate; D051379:Mice; D008810:Mice, Inbred C57BL; D009928:Organ Specificity; D049268:Positron-Emission Tomography / Q000379:methods*; D011471:Prostatic Neoplasms / Q000000981:diagnostic imaging* / Q000378:metabolism*; D011832:Radiation Injuries / Q000175:diagnosis / Q000209:etiology*; D019275:Radiopharmaceuticals / Q000493:pharmacokinetics / Q000633:toxicity; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D014018:Tissue Distribution; D018675:Toxicity Tests; D051598:Whole Body Imaging / Q000379:methods; D014915:Whole-Body Counting
chemical_list: D019275:Radiopharmaceuticals; C514960:fluorocholine; D002794:Choline
keywords: Acute toxicity; Biodistribution; Dosimetry; Preclinical; Prostate cancer; [(18)F]Fluorocholine