title: L1CAM expression in endometrial carcinomas: an ENITEC collaboration study.
abstract: BACKGROUND
  Identification of aggressive endometrioid endometrial carcinomas (EECs) and non-endometrioid carcinomas (NEECs) is essential to improve outcome. L1 cell adhesion molecule (L1CAM) expression is a strong prognostic marker in stage I EECs, but less is known about L1CAM expression in advanced-stage EECs and NEECs. This study analyses L1CAM expression in a clinically representative cohort of endometrial carcinomas.
  
  
  METHODS
  The expression of L1CAM was immunohistochemically determined in 1199 endometrial carcinomas, treated at one of the European Network for Individualized Treatment of Endometrial Cancer (ENITEC) centres. Staining was considered positive when >10% of the tumour cells expressed L1CAM. The association between L1CAM expression and several clincopathological characteristics and disease outcome was calculated.
  
  
  RESULTS
  In all, L1CAM was expressed in 10% of the 935 stage I EECs, 18% of the 160 advanced stage EECs, and 75% of the 104 NEECs. The expression of L1CAM was associated with advanced stage, nodal involvement, high tumour grade, non-endometrioid histology, lymphovascular space invasion, and distant recurrences in all cases, and with reduced survival in the EECs, but not in the NEECs.
  
  
  CONCLUSIONS
  The expression of L1CAM is a strong predictor of poor outcome in EECs, but not NEECs. It is strongly associated with non-endometrioid histology and distant spread, and could improve the postoperative selection of high-risk endometrial carcinomas. The value of L1CAM expression in the preoperative selection of high-risk endometrial carcinomas should be studied.
authors: Department of Obstetrics and Gynaecology, Radboud University Medical Center, Geert Grooteplein 10, Nijmegen 6525GA, The Netherlands.
authors: Louis Jm
authors: LJ
authors: van der Putten
authors: Department of Pathology, Radboud University Medical Center, Geert Grooteplein 10, Nijmegen 6525GA, The Netherlands.
authors: Nicole Cm
authors: NC
authors: Visser
authors: Department of Pathology, Anthoni van Leeuwenhoek Hospital, Plesmanlaan 121, Amsterdam 1066CX, The Netherlands.
authors: Koen
authors: K
authors: van de Vijver
authors: Department of Pathology and Molecular Genetics and Research Laboratory, Hospital Universitari Arnau de Vilanova, University of Lleida, IRBLLEIDA, Avenida Alcalde Rovira Roure, 80, Lleida 25198, Spain.
authors: Maria
authors: M
authors: Santacana
authors: Institute of Pathology, University Medical Center Freiburg, Hugstetter Strasse 55, Freiburg 79106, Germany.
authors: Peter
authors: P
authors: Bronsert
authors: Department of Pathology, Radboud University Medical Center, Geert Grooteplein 10, Nijmegen 6525GA, The Netherlands.
authors: Johan
authors: J
authors: Bulten
authors: Department of Obstetrics and Gynecology, University Medical Center Freiburg, Hugstetter Strasse 55, Freiburg 79106, Germany.|German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg D-69120, Germany.
authors: Marc
authors: M
authors: Hirschfeld
authors: Biomedical Research Group in Gynecology, Vall Hebron Institute of Research (VHIR), Universitat Autònoma de Barcelona, Passeig de la Vall d'Hebron, 119-129, Barcelona 08035, Spain.
authors: Eva
authors: E
authors: Colas
authors: Biomedical Research Group in Gynecology, Vall Hebron Institute of Research (VHIR), Universitat Autònoma de Barcelona, Passeig de la Vall d'Hebron, 119-129, Barcelona 08035, Spain.|Gynecological Department, Vall Hebron University Hospital, Passeig de la Vall d'Hebron, 119-129, Barcelona 08035, Spain.
authors: Antonio
authors: A
authors: Gil-Moreno
authors: Department of Pathology, Vall Hebron University Hospital, Passeig de la Vall d'Hebron, 119-129, Barcelona 08035, Spain.
authors: Angel
authors: A
authors: Garcia
authors: Department of Obstetrics and Gynecology, Hospital del Mar, Passeig Marítim, 25-29, Barcelona 08003, Spain.
authors: Gemma
authors: G
authors: Mancebo
authors: Department of Pathology, Hospital del Mar, Passeig Marítim, 25-29, Barcelona 08003, Spain.
authors: Fransesc
authors: F
authors: Alameda
authors: Department of Obstetrics and Gynecology, Haukeland University Hospital, Jonas Lies vei 65, Bergen 5021, Norway.
authors: Jone
authors: J
authors: Trovik
authors: Department of Clinical Science, University of Bergen, PO Box 7800, Bergen 5020, Norway.|Center for Cancer Biomarkers (CCBIO), University of Bergen, PO Box 7800, Bergen 5020, Norway.
authors: Reidun K
authors: RK
authors: Kopperud
authors: Department of Pathology, University of Turku, PO Box 7245, Laskut, Turku 01051, Finland.
authors: Jutta
authors: J
authors: Huvila
authors: Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, University Hospital Gasthuisberg, Herestraat 49, Leuven 3000, Belgium.
authors: Stefanie
authors: S
authors: Schrauwen
authors: Department of Obstetrics and Gynecology, Bichat-Claude Bernard Hospital, 46 Rue Henri Huchard, Paris 75018, France.
authors: Martin
authors: M
authors: Koskas
authors: Department of Pathology, Bichat-Claude Bernard Hospital, 46 Rue Henri Huchard, Paris 75018, France.
authors: Francine
authors: F
authors: Walker
authors: Department of Gynecology and Obstetrics, Faculty of Medicine, Masaryk University, Kamenice 5, Brno 625 00, Czech Republic.
authors: Vit
authors: V
authors: Weinberger
authors: Department of Gynecology and Obstetrics, Faculty of Medicine, Masaryk University, Kamenice 5, Brno 625 00, Czech Republic.
authors: Lubos
authors: L
authors: Minar
authors: Institute of Pathology, Faculty of Medicine, Masaryk University, Kamenice 5, Brno 625 00, Czech Republic.
authors: Eva
authors: E
authors: Jandakova
authors: Department of Obstetrics and Gynaecology, Canisius-Wilhelmina Hospital, Weg door Jonkerbos 100, Nijmegen 6532SZ, The Netherlands.
authors: Marc Plm
authors: MP
authors: Snijders
authors: Department of Pathology, Canisius-Wilhelmina Hospital, Weg door Jonkerbos 100, Nijmegen 6532SZ, The Netherlands.
authors: Saskia
authors: S
authors: van den Berg-van Erp
authors: Department of Pathology and Molecular Genetics and Research Laboratory, Hospital Universitari Arnau de Vilanova, University of Lleida, IRBLLEIDA, Avenida Alcalde Rovira Roure, 80, Lleida 25198, Spain.
authors: Xavier
authors: X
authors: Matias-Guiu
authors: Department of Obstetrics and Gynecology, Haukeland University Hospital, Jonas Lies vei 65, Bergen 5021, Norway.
authors: Helga B
authors: HB
authors: Salvesen
authors: Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, University Hospital Gasthuisberg, Herestraat 49, Leuven 3000, Belgium.
authors: Frederic
authors: F
authors: Amant
authors: Department of Obstetrics and Gynaecology, Radboud University Medical Center, Geert Grooteplein 10, Nijmegen 6525GA, The Netherlands.
authors: Leon Fag
authors: LF
authors: Massuger
authors: Department of Obstetrics and Gynaecology, TweeSteden Hospital, Doctor Deelenlaan 5, Tilburg 5042AD, The Netherlands.
authors: Johanna Ma
authors: JM
authors: Pijnenborg
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002277:Carcinoma / Q000737:chemistry / Q000401:mortality / Q000473:pathology; D018269:Carcinoma, Endometrioid / Q000737:chemistry* / Q000401:mortality / Q000473:pathology; D016889:Endometrial Neoplasms / Q000737:chemistry* / Q000401:mortality / Q000473:pathology; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D008207:Lymphatic Metastasis; D008875:Middle Aged; D060787:Neoplasm Grading; D009361:Neoplasm Invasiveness; D009363:Neoplasm Proteins / Q000032:analysis*; D009367:Neoplasm Staging; D039842:Neural Cell Adhesion Molecule L1 / Q000032:analysis*; D011379:Prognosis; D012008:Recurrence; D016896:Treatment Outcome
chemical_list: D009363:Neoplasm Proteins; D039842:Neural Cell Adhesion Molecule L1