title: Unusual ganglioglioma with extensive calcification and ossification.
abstract: Ganglioglioma is a slow-growing relatively low-grade mixed glioneuronal tumor with most cases corresponding to the WHO Grade I category. It frequently presents with seizures. The temporal lobe is the most common location followed by frontal, parietal, and occipital lobes. These generally behave in a benign fashion and have a favorable prognosis. We describe a case of a 24-year-old male presenting with convulsions and a calcified parieto-occipital mass. This mass removed from the parietal lobe showed neoplastic glial and dysplastic neuronal tissue amidst extensive areas of calcification and foci of ossification. On immunohistochemistry, the glial component expressed glial fibrillary acidic protein whereas the dysplastic neuronal component expressed synaptophysin and CD34. Epithelial membrane antigen was negative and Ki-67 showed a low proliferative index. After the surgery, the patient is free of neurological symptoms. Widespread calcification and ossification are very unusual in ganglioglioma, which prompted us to report this case.
authors: Department of Histopathology, Metropolis Healthcare Limited, Mumbai, Maharashtra, India.
authors: Vikas Shashikant
authors: VS
authors: Kavishwar
authors: Department of Histopathology, Metropolis Healthcare Limited, Mumbai, Maharashtra, India.
authors: Kirti G
authors: KG
authors: Chadha
authors: Department of Histopathology, Metropolis Healthcare Limited, Mumbai, Maharashtra, India.
authors: Shaikhali Moiz
authors: SM
authors: Barodawala
authors: Department of Histopathology, Metropolis Healthcare Limited, Mumbai, Maharashtra, India.
authors: Anuradha Krishna
authors: AK
authors: Murthy
mesh_terms: D018952:Antigens, CD34 / Q000032:analysis; D014408:Biomarkers, Tumor / Q000032:analysis; D001932:Brain Neoplasms / Q000175:diagnosis* / Q000473:pathology*; D002114:Calcinosis / Q000175:diagnosis / Q000473:pathology*; D018303:Ganglioglioma / Q000175:diagnosis* / Q000473:pathology*; D006651:Histocytochemistry; D006801:Humans; D007150:Immunohistochemistry; D019394:Ki-67 Antigen / Q000032:analysis; D008297:Male; D008853:Microscopy; D009999:Ossification, Heterotopic / Q000175:diagnosis / Q000473:pathology*; D012640:Seizures / Q000209:etiology; D016708:Synaptophysin / Q000032:analysis; D055815:Young Adult
chemical_list: D018952:Antigens, CD34; D014408:Biomarkers, Tumor; D019394:Ki-67 Antigen; D016708:Synaptophysin