title: Effects of lumbar drainage on CSF dynamics in subarachnoid hemorrhage condition: A computational study.
abstract: Lumbar drainage is considered a therapeutic measure in treatment of subarachnoid hemorrhage. However, the evidence on the effectiveness of this method is still inconclusive. In this study, a subject-specific three dimensional model of the cerebrospinal fluid (CSF) pathways and compartments was developed. The ventricular and the cranial and spinal subarachnoid spaces were reconstructed using magnetic resonance images. Occurrence of subarachnoid hemorrhage was modeled. Since the presence of blood in the CSF spaces is known to be the cause of complications such as cerebral vasospasm, concentration of blood in these spaces was investigated. Two cases of lumbar drains that were different in the drainage rate were studied. Temporal variations of concentration of blood in CSF spaces were calculated. It was observed that lumbar drainage accelerates the clearance of blood and, thereby, the spasmogens present in the cranial and spinal subarachnoid space. Higher clearance rates were observed at higher drainage rates.
authors: Faculty of Biomedical Engineering, Amirkabir University of Technology, Tehran, Iran.
authors: Ehsan
authors: E
authors: Abolfazli
authors: Faculty of Biomedical Engineering, Amirkabir University of Technology, Tehran, Iran. Electronic address: Nasser@aut.ac.ir.
authors: Nasser
authors: N
authors: Fatouraee
authors: Functional Neurosurgery Research Centre, Shoahada Tajrish Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors: Amir Saeed
authors: AS
authors: Seddighi
mesh_terms: D000328:Adult; D002555:Cerebrospinal Fluid / Q000502:physiology*; D019295:Computational Biology; D003198:Computer Simulation; D004322:Drainage; D005260:Female; D006801:Humans; D057446:Hydrodynamics; D008954:Models, Biological; D013345:Subarachnoid Hemorrhage / Q000628:therapy*; D013346:Subarachnoid Space / Q000502:physiology
keywords: Cerebrospinal fluid; Computational fluid dynamics; Finite element method; Lumbar drainage; Subarachnoid hemorrhage