title: [18F]-Sodium fluoride uptake in Takayasu arteritis.
abstract: While18F-fluorodeoxyglucose and18F-sodium fluoride with positron emission tomography relate with inflammation and calcification, their role in the assessment of patients with Takayasu arteritis has not yet been studied.
  
  
  
  We present 5 patients with suspected active metabolic disease who underwent PET with18F-fluorodeoxyglucose and18F-sodium fluoride in order to explore the locations and correlations of18F-fluorodeoxyglucose and18F-sodium fluoride uptakes. Diagnosis of metabolic active disease was based on18F-fluorodeoxyglucose uptake.
  
  
  
  We studied 3 female patients and 2 male patients. Median age was 29 years (min: 19 max: 63). In areas with atherosclerotic plaques, we found a negative correlation between18F-sodium fluoride and18F-fluorodeoxyglucose uptakes (r = -0.78) (P = .001). Meanwhile, in areas with only metabolic active disease, we found a positive correlation between18F-sodium fluoride and18F-fluorodeoxyglucose uptakes (r = 0.94) (P = .019).
  
  
  
  In Takayasu arteritis,18F-sodium fluoride uptake can document different stages of metabolic disease, even in the absence of active metabolic disease or symptoms.
authors: National Institute of Cardiology "Ignacio Chávez", Mexico City, Mexico.|PET/CT Unit, National Autonomous University of Mexico, Mexico City, Mexico.
authors: E
authors: E
authors: Alexanderson-Rosas
authors: Department of Nuclear Medicine and Molecular Imaging, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
authors: A G
authors: AG
authors: Monroy-Gonzalez
authors: Department of Nuclear Medicine and Molecular Imaging, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
authors: Luis Eduardo
authors: LE
authors: Juarez-Orozco
authors: National Institute of Cardiology "Ignacio Chávez", Mexico City, Mexico.
authors: M M
authors: MM
authors: Martinez-Aguilar
authors: National Institute of Cancer, Mexico, Mexico.
authors: E
authors: E
authors: Estrada
authors: National Institute of Cancer, Mexico, Mexico.
authors: I
authors: I
authors: Soldevilla
authors: National Institute of Cancer, Mexico, Mexico.
authors: O
authors: O
authors: Garcia-Pérez
authors: National Institute of Cardiology "Ignacio Chávez", Mexico City, Mexico. mesoto50@hotmail.com.
authors: M E
authors: ME
authors: Soto-Lopez
mesh_terms: D000328:Adult; D001011:Aorta / Q000000981:diagnostic imaging; D002114:Calcinosis / Q000000981:diagnostic imaging; D005260:Female; D005462:Fluorine Radioisotopes / Q000493:pharmacokinetics*; D019788:Fluorodeoxyglucose F18 / Q000493:pharmacokinetics; D006801:Humans; D007249:Inflammation; D008297:Male; D008875:Middle Aged; D049268:Positron-Emission Tomography; D012969:Sodium Fluoride / Q000493:pharmacokinetics*; D013625:Takayasu Arteritis / Q000000981:diagnostic imaging*; D055815:Young Adult
chemical_list: D005462:Fluorine Radioisotopes; D019788:Fluorodeoxyglucose F18; D012969:Sodium Fluoride
keywords: 18F-Fluorodeoxyglucose (18F-FDG); 18F-sodium fluoride (18F-NaF); Calcification; Inflammation; PET/CT imaging; Takayasu arteritis