title: Polypropylene mesh for nasal septal perforation repair: an experimental study.
abstract: The aim of this study is to determine the effectiveness and biocompatibility of polypropylene mesh for the repair of nasal septal perforations in an animal model on rabbits. A full-thickness nasal septal perforation with a diameter of nearly 10 × 10 mm was created on 12 rabbits, and then the perforation was reconstructed with two different methods. We used mucosal flaps and polypropylene mesh as an interpositional graft in group 1. Only mucosal flaps were used for reconstruction and are identified as group 2. After 4 weeks, we removed the nasal septum of the rabbits and performed histopathological examinations for acute rejection, infection, inflammatory response, fibrosis, and granuloma formation. We found perforation closure rates of 75 and 25 % in groups 1 and 2, respectively. Inflammatory response was seen in all specimens of group 1 (100 %). The inflammatory response was +1 in five of the specimens (62.5 %), +2 in one specimen (12.5 %), and +3 in two specimens (25 %). Mild fibrosis around the mesh was detected in four specimens (50 %), medium-level fibrosis was detected in one (12.5 %), and no fibrosis was detected in three (37.5 %). Severe fibrosis was not seen in any specimens. The foreign-body reaction was limited to a few giant cells, and granuloma formation was seen in two specimens (25 %). The propylene mesh showed excellent biocompatibility with the septal mucosa, and it can, therefore, be used for the repair of septal perforation as an interpositional graft safely.
authors: Bağcılar Hospitalist Hospital, Yavuz Selim Mahallesi. H.Ahmet Yesevi Cd. 26/A Sok., 34203, Bağcılar/İstanbul, Turkey. kadiryucebas@gmail.com.
authors: Kadir
authors: http://orcid.org/0000-0002-7159-4307
authors: K
authors: Yücebaş
authors: Department of Otorhinolaryngology, Bağcılar Training and Research Hospital, Istanbul, Turkey.
authors: Ümit
authors: Ü
authors: Taşkın
authors: Department of Otorhinolaryngology, Bağcılar Training and Research Hospital, Istanbul, Turkey.
authors: Mehmet Faruk
authors: MF
authors: Oktay
authors: Department of Otorhinolaryngology, Bağcılar Training and Research Hospital, Istanbul, Turkey.
authors: Hasan Deniz
authors: HD
authors: Tansuker
authors: Department of Otorhinolaryngology, Bağcılar Training and Research Hospital, Istanbul, Turkey.
authors: Mehmet
authors: M
authors: Erdil
authors: Department of Pathology, Bağcılar Training and Research Hospital, Istanbul, Turkey.
authors: Serdar
authors: S
authors: Altınay
authors: Department of Plastic, Reconstructive and Aesthetic Surgery, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.
authors: Erol
authors: E
authors: Kozanoğlu
authors: Department of Plastic, Reconstructive and Aesthetic Surgery, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.
authors: Samet Vasfi
authors: SV
authors: Kuvat
mesh_terms: D000818:Animals; D001672:Biocompatible Materials; D008422:Materials Testing; D009297:Nasal Mucosa / Q000601:surgery; D061270:Nasal Septal Perforation / Q000601:surgery*; D011126:Polypropylenes; D011817:Rabbits; D019651:Plastic Surgery Procedures / Q000295:instrumentation* / Q000379:methods; D013524:Surgical Flaps; D013526:Surgical Mesh; D016896:Treatment Outcome
chemical_list: D001672:Biocompatible Materials; D011126:Polypropylenes
keywords: Interpositional graft; Polypropylene mesh; Septal perforation; Septal perforation surgery