title: An autopsy case of zinc chloride poisoning.
abstract: Ingestion of large amounts of zinc chloride causes corrosive gastroenteritis with vomiting, abdominal pain, and diarrhea. Some individuals experience shock after ingesting large amounts of zinc chloride, resulting in fatality. Here, we present the results of an administrative autopsy performed on a 70-year-old man who ingested zinc chloride solution and died. After drinking the solution, he developed vomiting, abdominal pain, and diarrhea, and called for an ambulance. Except for tachycardia, his vital signs were stable at presentation. However, he developed hypotension and severe metabolic acidosis and died. The patient's blood zinc concentration on arrival was high at 3030μg/dL. Liver cirrhosis with cloudy yellow ascites was observed, however, there were no clear findings of gastrointestinal perforation. The gastric mucosa was gray-brown, with sclerosis present in all gastric wall layers. Zinc staining was strongly positive in all layers. There was almost no postmortem degeneration of the gastric mucosal epithelium, and hypercontracture of the smooth muscle layer was observed. Measurement of the zinc concentration in the organs revealed the highest concentration in the gastric mucosa, followed by the pancreas and spleen. Clinically, corrosive gastroenteritis was the cause of death. However, although autopsy revealed solidification in the esophagus and gastric mucosa, there were no findings in the small or large intestine. Therefore, metabolic acidosis resulting from organ damage was the direct cause of death.
authors: Division of Legal Medicine, Department of Community Medicine and Social Healthcare Science, Kobe University Graduate School of Medicine, Kobe, Japan; Medical Examiner's Office of Hyogo Prefecture, Kobe, Japan. Electronic address: kondo@med.kobe-u.ac.jp.
authors: Takeshi
authors: T
authors: Kondo
authors: Division of Legal Medicine, Department of Community Medicine and Social Healthcare Science, Kobe University Graduate School of Medicine, Kobe, Japan; Medical Examiner's Office of Hyogo Prefecture, Kobe, Japan.
authors: Motonori
authors: M
authors: Takahashi
authors: Forensic Science Laboratory, Hyogo Prefectural Police Headquarters, Kobe, Japan.
authors: Seiya
authors: S
authors: Watanabe
authors: Emergency Department, Kobe City Medical Center General Hospital, Kobe, Japan.
authors: Masatomo
authors: M
authors: Ebina
authors: Emergency Department, Kobe City Medical Center General Hospital, Kobe, Japan.
authors: Daisuke
authors: D
authors: Mizu
authors: Emergency Department, Kobe City Medical Center General Hospital, Kobe, Japan.
authors: Koichi
authors: K
authors: Ariyoshi
authors: Department of Legal Medicine, Ehime University Graduate School of Medicine, Toon, Japan.
authors: Migiwa
authors: M
authors: Asano
authors: Medical Examiner's Office of Hyogo Prefecture, Kobe, Japan.
authors: Yasushi
authors: Y
authors: Nagasaki
authors: Division of Legal Medicine, Department of Community Medicine and Social Healthcare Science, Kobe University Graduate School of Medicine, Kobe, Japan; Medical Examiner's Office of Hyogo Prefecture, Kobe, Japan.
authors: Yasuhiro
authors: Y
authors: Ueno
mesh_terms: D000368:Aged; D001344:Autopsy; D002712:Chlorides / Q000506:poisoning*; D017809:Fatal Outcome; D049429:Forensic Pathology; D006801:Humans; D008297:Male; D011041:Poisoning / Q000175:diagnosis*; D017967:Zinc Compounds / Q000506:poisoning*
chemical_list: D002712:Chlorides; D017967:Zinc Compounds; C016837:zinc chloride
keywords: Astringency; Forensic pathology; Metabolic acidosis; Permeability; Zinc chloride