title: Cannabinoids As Potential Treatment for Chemotherapy-Induced Nausea and Vomiting.
abstract: Despite the advent of classic anti-emetics, chemotherapy-induced nausea is still problematic, with vomiting being somewhat better managed in the clinic. If post-treatment nausea and vomiting are not properly controlled, anticipatory nausea-a conditioned response to the contextual cues associated with illness-inducing chemotherapy-can develop. Once it develops, anticipatory nausea is refractive to current anti-emetics, highlighting the need for alternative treatment options. One of the first documented medicinal uses of Δ(9)-tetrahydrocannabinol (Δ(9)-THC) was for the treatment of chemotherapy-induced nausea and vomiting (CINV), and recent evidence is accumulating to suggest a role for the endocannabinoid system in modulating CINV. Here, we review studies assessing the therapeutic potential of cannabinoids and manipulations of the endocannabinoid system in human patients and pre-clinical animal models of nausea and vomiting.
authors: Department of Psychology and Collaborative Neuroscience Graduate Program, University of Guelph Guelph, ON, Canada.
authors: Erin M
authors: EM
authors: Rock
authors: Department of Psychology and Collaborative Neuroscience Graduate Program, University of Guelph Guelph, ON, Canada.
authors: Linda A
authors: LA
authors: Parker
keywords: acute nausea; anticipatory nausea; cannabinoid; conditioned gaping; vomiting