title: Population-Based Precision Cancer Screening: A Symposium on Evidence, Epidemiology, and Next Steps.
abstract: Precision medicine, an emerging approach for disease treatment that takes into account individual variability in genes, environment, and lifestyle, is under consideration for preventive interventions, including cancer screening. On September 29, 2015, the National Cancer Institute sponsored a symposium entitled "Precision Cancer Screening in the General Population: Evidence, Epidemiology, and Next Steps". The goal was two-fold: to share current information on the evidence, practices, and challenges surrounding precision screening for breast, cervical, colorectal, lung, and prostate cancers, and to allow for in-depth discussion among experts in relevant fields regarding how epidemiology and other population sciences can be used to generate evidence to inform precision screening strategies. Attendees concluded that the strength of evidence for efficacy and effectiveness of precision strategies varies by cancer site, that no one research strategy or methodology would be able or appropriate to address the many knowledge gaps in precision screening, and that issues surrounding implementation must be researched as well. Additional discussion needs to occur to identify the high priority research areas in precision cancer screening for pertinent organs and to gather the necessary evidence to determine whether further implementation of precision cancer screening strategies in the general population would be feasible and beneficial. Cancer Epidemiol Biomarkers Prev; 25(11); 1449-55. ©2016 AACR.
authors: Division of Cancer Control and Population Studies, National Cancer Institute, Bethesda, Maryland. marcusp@mail.nih.gov.
authors: Pamela M
authors: PM
authors: Marcus
authors: Department of Applied Health Research, University College London, London, England, United Kingdom.
authors: Nora
authors: N
authors: Pashayan
authors: Division of Environmental Health Sciences, University of Minnesota School of Public Health, Minneapolis, Minnesota.
authors: Timothy R
authors: TR
authors: Church
authors: Division of Cancer Control and Population Studies, National Cancer Institute, Bethesda, Maryland.
authors: V Paul
authors: VP
authors: Doria-Rose
authors: Department of Research and Evaluation, Kaiser Permanente Southern California, Pasadena, California.
authors: Michael K
authors: MK
authors: Gould
authors: Department of Biostatistics and Epidemiology, University of Pennsylvania, Philadelphia, Pennsylvania.
authors: Rebecca A
authors: RA
authors: Hubbard
authors: Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland.
authors: Michael
authors: M
authors: Marrone
authors: Department of Public Health Sciences, University of California, Davis, Sacramento, California.
authors: Diana L
authors: DL
authors: Miglioretti
authors: Department of Public Health and Primary Care and Department of Oncology, University of Cambridge, Cambridge, England, United Kingdom.
authors: Paul D
authors: PD
authors: Pharoah
authors: Division of Cancer Prevention, National Cancer Institute, Bethesda, Maryland.
authors: Paul F
authors: PF
authors: Pinsky
authors: Division of Cancer Control and Population Studies, National Cancer Institute, Bethesda, Maryland.
authors: Katherine A
authors: KA
authors: Rendle
authors: Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland.
authors: Hilary A
authors: HA
authors: Robbins
authors: Division of Cancer Control and Population Studies, National Cancer Institute, Bethesda, Maryland.
authors: Megan C
authors: MC
authors: Roberts
authors: Carbone Cancer Center, University of Wisconsin-Madison, Madison, Wisconsin.
authors: Betsy
authors: B
authors: Rolland
authors: Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland.
authors: Mark
authors: M
authors: Schiffman
authors: Department of Clinical Science, UT Southwestern Medical Center, Dallas, Texas.
authors: Jasmin A
authors: JA
authors: Tiro
authors: Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center, New York, New York.
authors: Ann G
authors: AG
authors: Zauber
authors: Division of Cancer Control and Population Studies, National Cancer Institute, Bethesda, Maryland.
authors: Deborah M
authors: DM
authors: Winn
authors: Division of Cancer Control and Population Studies, National Cancer Institute, Bethesda, Maryland.|Office of Public Health Genomics, Centers for Disease Control and Prevention, Atlanta, Georgia.
authors: Muin J
authors: MJ
authors: Khoury
mesh_terms: D055088:Early Detection of Cancer; D005260:Female; D006801:Humans; D008297:Male; D057285:Precision Medicine / Q000379:methods*