title: Understanding Caries From the Oral Microbiome Perspective.
abstract: Dental caries is a major disease of the oral cavity with profound clinical significance. Caries results from a transition of a healthy oral microbiome into an acidogenic community of decreased microbial diversity in response to excessive dietary sugar intake. Microbiological cultivation, molecular identification, gene expression and metabolomic analyses show the importance of the entire microbial community in understanding the role of the microbiome in the pathology of caries.
authors: Anne C R
authors: AC
authors: Tanner
authors: Christine A
authors: CA
authors: Kressirer
authors: Lina L
authors: LL
authors: Faller
mesh_terms: D000143:Acids; D018441:Biofilms; D003731:Dental Caries / Q000382:microbiology*; D003743:Dental Enamel / Q000382:microbiology; D003804:Dentin / Q000382:microbiology; D006801:Humans; D006863:Hydrogen-Ion Concentration; D056265:Microbial Interactions / Q000502:physiology; D064307:Microbiota / Q000502:physiology*; D009055:Mouth / Q000382:microbiology*; D017213:Root Caries / Q000382:microbiology
chemical_list: D000143:Acids