title: The plasma membrane monoamine transporter (PMAT): Structure, function, and role in organic cation disposition.
abstract: Plasma membrane monoamine transporter (PMAT) is a new polyspecific organic cation transporter that transports a variety of biogenic amines and xenobiotic cations. Highly expressed in the brain, PMAT represents a major uptake2transporter for monoamine neurotransmitters. At the blood-cerebrospinal fluid (CSF) barrier, PMAT is the principal organic cation transporter for removing neurotoxins and drugs from the CSF. Here I summarize our latest understanding of PMAT and its roles in monoamine uptake and xenobiotic disposition.
authors: Department of Pharmaceutics, University of Washington, Seattle, Washington, USA. jowang@uw.edu.
authors: J
authors: J
authors: Wang
mesh_terms: D000818:Animals; D001679:Biogenic Amines / Q000378:metabolism*; D006801:Humans; D050480:Plasma Membrane Neurotransmitter Transport Proteins; D015262:Xenobiotics / Q000493:pharmacokinetics*
chemical_list: D001679:Biogenic Amines; D050480:Plasma Membrane Neurotransmitter Transport Proteins; D015262:Xenobiotics