title: Projection-Specific Dynamic Regulation of Inhibition in Amygdala Micro-Circuits.
abstract: Cannabinoid receptor type 1 (CB1R)-expressing CCK interneurons are key regulators of cortical circuits. Here we report that retrograde endocannabinoid signaling and CB1R-mediated regulation of inhibitory synaptic transmission onto basal amygdala principal neurons strongly depend on principal neuron projection target. Projection-specific asymmetries in the regulation of local inhibitory micro-circuits may contribute to the selective activation of distinct amygdala output pathways during behavioral changes.
authors: Friedrich Miescher Institute for Biomedical Research, 4058 Basel, Switzerland; University of Basel, 4000 Basel, Switzerland.
authors: Elisabeth
authors: E
authors: Vogel
authors: Friedrich Miescher Institute for Biomedical Research, 4058 Basel, Switzerland.
authors: Sabine
authors: S
authors: Krabbe
authors: Friedrich Miescher Institute for Biomedical Research, 4058 Basel, Switzerland.
authors: Jan
authors: J
authors: Gründemann
authors: Friedrich Miescher Institute for Biomedical Research, 4058 Basel, Switzerland.
authors: Jaclyn I
authors: JI
authors: Wamsteeker Cusulin
authors: Friedrich Miescher Institute for Biomedical Research, 4058 Basel, Switzerland; University of Basel, 4000 Basel, Switzerland. Electronic address: andreas.luthi@fmi.ch.
authors: Andreas
authors: A
authors: Lüthi
mesh_terms: D000679:Amygdala / Q000166:cytology* / Q000378:metabolism / Q000502:physiology*; D000818:Animals; D002766:Cholecystokinin / Q000235:genetics / Q000502:physiology; D007395:Interneurons / Q000502:physiology*; D008071:Lipoprotein Lipase / Q000096:biosynthesis; D008297:Male; D051379:Mice; D008822:Mice, Transgenic; D008994:Monoacylglycerol Lipases / Q000096:biosynthesis; D009433:Neural Inhibition / Q000502:physiology*; D009473:Neuronal Plasticity / Q000502:physiology; D043884:Receptor, Cannabinoid, CB1 / Q000502:physiology; D009435:Synaptic Transmission
chemical_list: D043884:Receptor, Cannabinoid, CB1; D002766:Cholecystokinin; D008994:Monoacylglycerol Lipases; D008071:Lipoprotein Lipase