title: [Rank of outcome parameters in the treatment of depression : Results of a Delphi panel survey].
abstract: BACKGROUND
  In the context of new drug benefit assessments a list of outcome parameter are evaluated. Currently it is unclear, how different outcome parameters are weighed in the overall assessment.
  
  
  OBJECTIVE
  The objective of the survey is to rank relevant outcome parameters in the treatment of depression, which may be considered in benefit the assessment of new antidepressants.
  
  
  METHODS
  In 2015 a Delphi panel survey with 30 general practitioners and specialists in Germany was performed regarding the benefit assessment of antidepressants. On the basis of two fictive casuistics (patients with depressive disorders) the physicians weighed a range of relevant outcome parameters regarding efficacy, quality of life, safety and tolerability according to their relevance to clinical practice.
  
  
  RESULTS
  Regarding efficacy, response, remission and recovery were rated as the most important outcomes. Regarding quality of life, handling of the daily household activities and mental performance were rated as most important. Suicidality was rated as the most important outcome regarding safety and tolerability.
  
  
  CONCLUSIONS
  Individual outcome parameters were rated differently by the physicians regarding their relevance to clinical practice. The results indicate that outcome parameters should be weighed differently when assessing the overall benefit of new antidepressants.
authors: Klinik für Psychiatrie, Psychotherapie und Psychosomatik, Uniklinik RWTH Aachen, Aachen, Deutschland.
authors: G
authors: G
authors: Gründer
authors: Klinik und Poliklinik für Psychiatrie und Psychotherapie, Universitätsklinikum Carl Gustav Carus, Technische Universität Dresden, Dresden, Deutschland.
authors: M
authors: M
authors: Bauer
authors: Zentralinstitut für Seelische Gesundheit, Klinik für Psychiatrie und Psychotherapie, Universität Heidelberg, Medizinische Fakultät Mannheim, Mannheim, Deutschland.
authors: M
authors: M
authors: Deuschle
authors: Institut für Klinische Psychologie und Psychotherapie, Eberhard Karls Universität Tübingen, Tübingen, Deutschland.
authors: M
authors: M
authors: Hautzinger
authors: Medical Department, Lundbeck GmbH, Ericusspitze 2, 20457, Hamburg, Deutschland. lumf@lundbeck.com.
authors: M
authors: M
authors: Friede
authors: Klinik für Psychiatrie und Psychotherapie Gießen und Marburg, Vitos Klinikum Gießen-Marburg, Marburg, Deutschland.
authors: M J
authors: MJ
authors: Müller
mesh_terms: D000203:Activities of Daily Living / Q000523:psychology; D000328:Adult; D000368:Aged; D000928:Antidepressive Agents / Q000009:adverse effects / Q000627:therapeutic use*; D015897:Comorbidity; D003697:Delphi Technique; D003866:Depressive Disorder / Q000175:diagnosis / Q000188:drug therapy* / Q000523:psychology; D004347:Drug Interactions; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D017063:Outcome Assessment, Health Care; D017060:Patient Satisfaction; D011788:Quality of Life / Q000523:psychology; D012307:Risk Factors; D013405:Suicide / Q000523:psychology; D000092864:Suicide Prevention
chemical_list: D000928:Antidepressive Agents
keywords: Antidepressants; Benefit assessment; Delphi-panel survey; Depression; Outcome parameter