title: The molecular mechanisms of action of PPAR-γ agonists in the treatment of corneal alkali burns (Review).
abstract: Corneal alkali burns (CAB) are characterized by injury-induced inflammation, fibrosis and neovascularization (NV), and may lead to blindness. This review evaluates the current knowledge of the molecular mechanisms responsible for CAB. The processes of cytokine production, chemotaxis, inflammatory responses, immune response, cell signal transduction, matrix metalloproteinase production and vascular factors in CAB are discussed. Previous evidence indicates that peroxisome proliferator-activated receptor γ (PPAR-γ) agonists suppress immune responses, inflammation, corneal fibrosis and NV. This review also discusses the role of PPAR-γ as an anti-inflammatory, anti-fibrotic and anti-angiogenic agent in the treatment of CAB, as well as the potential role of PPAR-γ in the pathological process of CAB. There have been numerous studies evaluating the clinical profiles of CAB, and the aim of this systematic review was to summarize the evidence regarding the treatment of CAB with PPAR-γ agonists.
authors: Department of Ophthalmology, China-Japan Union Hospital of Jilin University, Changchun, Jilin 130033, P.R. China.
authors: Hongyan
authors: H
authors: Zhou
authors: Department of Ophthalmology, The Second Hospital of Jilin University, Changchun, Jilin 130000, P.R. China.
authors: Wensong
authors: W
authors: Zhang
authors: Department of Ophthalmology, China-Japan Union Hospital of Jilin University, Changchun, Jilin 130033, P.R. China.
authors: Miaomiao
authors: M
authors: Bi
authors: Department of Ophthalmology, China-Japan Union Hospital of Jilin University, Changchun, Jilin 130033, P.R. China.
authors: Jie
authors: J
authors: Wu
mesh_terms: D000468:Alkalies; D003315:Cornea / Q000473:pathology*; D005126:Eye Burns / Q000188:drug therapy* / Q000378:metabolism; D006801:Humans; D047495:PPAR gamma / Q000819:agonists* / Q000378:metabolism; D057170:Translational Research, Biomedical; D014945:Wound Healing
chemical_list: D000468:Alkalies; D047495:PPAR gamma