title: Impact of Decreased Serum Insulin-Like Growth Factor-1 Levels on Central Aortic Compliance in Small-for-Gestational-Age Infants.
abstract: Intrauterine growth restriction is associated with arterial hypertension in adulthood; however, the underlying mechanism is unclear.
  
  
  
  We hypothesized that serum insulin-like growth factor-1 (IGF-1) levels affect central aortic elastic properties and structure in small-for-gestational-age (SGA) infants.
  
  
  
  Eighteen SGA infants and 22 appropriate-for-gestational-age (AGA) infants were enrolled in this study. The serum IGF-1 level within 1 h of birth and abdominal aortic echo parameters at 1 week of age were retrospectively compared.
  
  
  
  In the SGA infants, IGF-1 levels (27.6 ± 17.7 vs. 42.6 ± 15 ng/ml, p = 0.006), aortic strain (10.2 ± 3.1 vs. 12.8 ± 3.1%, p = 0.01), and aortic distensibility (0.73 ± 0.19 vs. 0.92 ± 0.34 cm2/dyn × 10-4, p = 0.05) were significantly lower compared with AGA infants. By contrast, blood pressure, aortic intima-media thickness (aIMT) in relation to body weight (383 ± 163 vs. 256 ± 43 μm/kg, p < 0.001), aortic stiffness index in relation to body weight (2.0 ± 1.7 vs. 1.1 ± 0.4, p = 0.005), and arterial pressure-strain elastic modulus (293 ± 72 vs. 242 ± 78 mm Hg, p = 0.04) were higher compared with AGA infants. In the SGA infants, IGF-1 levels were significantly correlated with aortic strain (r = 0.49, p = 0.04), aIMT in relation to body weight (r = -0.61, p = 0.007), and aortic stiffness index in relation to body weight (r = -0.63, p = 0.005).
  
  
  
  Decreased serum IGF-1 levels in SGA infants may affect the vascular compliance and structure of the central aorta.
authors: Department of Paediatrics, Shinshu University School of Medicine, Matsumoto, Japan.
authors: Yohei
authors: Y
authors: Akazawa
authors: Motoko
authors: M
authors: Kamiya
authors: Shoko
authors: S
authors: Yamazaki
authors: Yoichiro
authors: Y
authors: Kawasaki
authors: Chizuko
authors: C
authors: Nakamura
authors: Yusuke
authors: Y
authors: Takeuchi
authors: Akira
authors: A
authors: Hachiya
authors: Mai
authors: M
authors: Kusakari
authors: Yukihide
authors: Y
authors: Miyosawa
authors: Noriko
authors: N
authors: Motoki
authors: Kenichi
authors: K
authors: Koike
authors: Tomohiko
authors: T
authors: Nakamura
mesh_terms: D001011:Aorta / Q000503:physiopathology*; D001724:Birth Weight; D059168:Carotid Intima-Media Thickness; D003187:Compliance; D005260:Female; D005317:Fetal Growth Retardation / Q000000981:diagnostic imaging / Q000503:physiopathology*; D005865:Gestational Age; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007236:Infant, Small for Gestational Age / Q000097:blood*; D007334:Insulin-Like Growth Factor I / Q000032:analysis*; D007564:Japan; D008297:Male; D012044:Regression Analysis; D012189:Retrospective Studies
chemical_list: D007334:Insulin-Like Growth Factor I