title: Correlation of Adrenomedullin Concentrations with Knee Osteoarthritis Grade.
abstract: BACKGROUND Adrenomedullin, a recently identified myokine, has an anti-inflammatory effect. Therefore, we aimed to assess the correlation of adrenomedullin concentrations with the presence and grade of severity of knee osteoarthritis (OA). MATERIAL AND METHODS We recruited 187 knee OA patients and 109 healthy subjects. The severity of OA was evaluated using the Kellgren-Lawrence grading system. RESULTS Compared with the control group, the knee OA group revealed markedly higher adrenomedullin concentrations. Serum and synovial fluid (SF) adrenomedullin concentrations increased with increased KL grades. CONCLUSIONS Serum and SF adrenomedullin concentrations show a correlation with the severity of knee OA.
authors: Department of Nursing, Hubei College of Chinese Medicine, Jingzhou, Hubei, China (mainland).
authors: Linghua
authors: L
authors: Liu
authors: Department of Orthopaedics, Pu'ai Hospital of Tongji Medical College of Huazhong University of Science and Technology, Wuhan, Hubei, China (mainland).
authors: Ruokun
authors: R
authors: Huang
authors: Department of Orthopaedics, Pu'ai Hospital of Tongji Medical College of Huazhong University of Science and Technology, Wuhan, Hubei, China (mainland).
authors: Dezhang
authors: D
authors: Ma
authors: Department of Orthopaedics, Pu'ai Hospital of Tongji Medical College of Huazhong University of Science and Technology, Wuhan, Hubei, China (mainland).
authors: Wenjun
authors: W
authors: Cheng
authors: Department of Orthopaedics, Pu'ai Hospital of Tongji Medical College of Huazhong University of Science and Technology, Wuhan, Hubei, China (mainland).
authors: Wei
authors: W
authors: Feng
authors: Department of Orthopaedics, Pu'ai Hospital of Tongji Medical College of Huazhong University of Science and Technology, Wuhan, Hubei, China (mainland).
authors: Danmou
authors: D
authors: Xing
authors: Department of Orthopaedics, Pu'ai Hospital of Tongji Medical College of Huazhong University of Science and Technology, Wuhan, Hubei, China (mainland).
authors: Wusheng
authors: W
authors: Kan
authors: Department of Orthopaedics, Pu'ai Hospital of Tongji Medical College of Huazhong University of Science and Technology, Wuhan, Hubei, China (mainland).
authors: Zhihong
authors: Z
authors: Xiao
mesh_terms: D053607:Adrenomedullin / Q000097:blood / Q000378:metabolism*; D000368:Aged; D015415:Biomarkers / Q000097:blood / Q000378:metabolism; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D020370:Osteoarthritis, Knee / Q000097:blood / Q000378:metabolism* / Q000473:pathology; D012720:Severity of Illness Index; D013582:Synovial Fluid / Q000378:metabolism
chemical_list: D015415:Biomarkers; D053607:Adrenomedullin