title: Single-walled carbon nanotube-loaded doxorubicin and Gd-DTPA for targeted drug delivery and magnetic resonance imaging.
abstract: An aspargine-glycine-arginine (NGR) peptide modified single-walled carbon nanotubes (SWCNTs) system, developed by a simple non-covalent approach, could be loaded with the anticancer drug doxorubicin (DOX) and magnetic resonance imaging (MRI) contrast agent gadolinium-diethylenetriamine pentaacetic acid (Gd-DTPA). This DOX- and Gd-DTPA-loaded NGR functionalized SWCNTs (DOX/NGR-SWCNTs/Gd-DPTA) retained both cytotoxicity of DOX and MRI contrast effect of Gd-DPTA. This drug delivery system showed excellent stability in physiological solutions. This DOX/NGR-SWCNTs/Gd-DPTA system could accumulate in tumors and enter into tumor cells, which facilitated combination chemotherapy with diagnosis of tumor in one system. An excellent in vitro anti-tumor effect was shown in MCF-7 cells treated by DOX/NGR-SWCNTs/Gd-DPTA, compared with DOX solution, DOX/SWCNTs and DOX/SWCNTs/Gd-DPTA. In vivo data of DOX/NGR-SWCNTs/Gd-DPTA group in tumor-bearing mice further confirmed that this system performed much higher tumor targeting capacity and anti-tumor efficacy than other control groups.
authors: a Department of MRI , The First Affiliated Hospital of Zhengzhou University , Zhengzhou , China.
authors: Chenyu
authors: C
authors: Yan
authors: b Department of Pharmaceutical Sciences , The First Affiliated Hospital of Zhengzhou University , Zhengzhou , China.
authors: Chengqun
authors: C
authors: Chen
authors: c School of Pharmaceutical Sciences , Zhengzhou University , Zhengzhou , China.
authors: Lin
authors: L
authors: Hou
authors: c School of Pharmaceutical Sciences , Zhengzhou University , Zhengzhou , China.
authors: Huijuan
authors: H
authors: Zhang
authors: a Department of MRI , The First Affiliated Hospital of Zhengzhou University , Zhengzhou , China.
authors: Yingyu
authors: Y
authors: Che
authors: b Department of Pharmaceutical Sciences , The First Affiliated Hospital of Zhengzhou University , Zhengzhou , China.
authors: Yuedong
authors: Y
authors: Qi
authors: b Department of Pharmaceutical Sciences , The First Affiliated Hospital of Zhengzhou University , Zhengzhou , China.
authors: Xiaojian
authors: X
authors: Zhang
authors: a Department of MRI , The First Affiliated Hospital of Zhengzhou University , Zhengzhou , China.
authors: Jingliang
authors: J
authors: Cheng
authors: c School of Pharmaceutical Sciences , Zhengzhou University , Zhengzhou , China.
authors: Zhenzhong
authors: Z
authors: Zhang
mesh_terms: D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics / Q000627:therapeutic use; D004317:Doxorubicin / Q000008:administration & dosage / Q000737:chemistry* / Q000493:pharmacokinetics / Q000627:therapeutic use*; D016503:Drug Delivery Systems; D019786:Gadolinium DTPA / Q000008:administration & dosage / Q000737:chemistry* / Q000493:pharmacokinetics / Q000494:pharmacology; D006801:Humans; D061986:MCF-7 Cells; D008279:Magnetic Resonance Imaging; D051379:Mice; D008807:Mice, Inbred BALB C; D015394:Molecular Structure; D037742:Nanotubes, Carbon / Q000737:chemistry*; D009374:Neoplasms, Experimental / Q000188:drug therapy*
chemical_list: D000903:Antibiotics, Antineoplastic; D037742:Nanotubes, Carbon; D004317:Doxorubicin; D019786:Gadolinium DTPA
keywords: NGR; SWCNTs; Targeted drug delivery; magnetic resonance imaging; tumor diagnosis