title: Network dynamics in dyslexia: Review and implications for remediation.
abstract: Extant neurobiological theories of dyslexia appear fractional in focusing on isolated brain regions, mechanisms, and functional pathways. A synthesis of current research shows support for an Interactive Specialization (IS) model of dyslexia involving the dysfunctional orchestration of a widely-distributed, attentionally-controlled, hierarchical, and interhemispheric circuit of intercommunicating neuronal networks. This circuitry is comprised principally of the frontostriatal-parietal cognitive control system of networks, the posterior corpus callosum, and the left arcuate fasciculus. During development, the coalescence of these functionally specialized regions, acting together, may be essential to preventing the core phonemic and phonological processing deficits defining the dyslexic phenotype. Research demonstrating an association of each with processing phonology presents the foundational outline for a comprehensive, integrative theory of dyslexia and suggests the importance of inclusive remedial efforts aimed at promoting interactions among all three networking territories.
authors: University of Toronto, Toronto, ON M5 S 1A1, Canada. Electronic address: john.kershner@utoronto.ca.
authors: John R
authors: JR
authors: Kershner
mesh_terms: D001921:Brain / Q000000981:diagnostic imaging / Q000503:physiopathology*; D003337:Corpus Callosum / Q000000981:diagnostic imaging / Q000503:physiopathology; D004410:Dyslexia / Q000000981:diagnostic imaging / Q000503:physiopathology*; D059907:Functional Neuroimaging; D006801:Humans; D008279:Magnetic Resonance Imaging; D009434:Neural Pathways / Q000000981:diagnostic imaging / Q000503:physiopathology; D010296:Parietal Lobe / Q000000981:diagnostic imaging / Q000503:physiopathology; D013702:Temporal Lobe / Q000000981:diagnostic imaging / Q000503:physiopathology
keywords: Arcuate fasciculus; Cognitive control; Corpus callosum; Dyslexia; Interactive specialization