title: Poligalen, a new coumarin from Polygala boliviensis, reduces the release of TNF and IL-6 independent of NF-kB downregulation.
abstract: An unusually substituted coumarin, named poligalen, was isolated from a chloroform extract of the aerial parts of Polygala boliviensis. This coumarin was identified by one- and two-dimensional NMR techniques, and the structure of the compound was confirmed by X-ray diffraction. Poligalen exhibits immunomodulatory effects, reducing the levels of IL-6 and TNF after LPS stimulation in peritoneal macrophages. However, poligalen potentiates NF-kB activation.
authors: Departamento de Saúde, Universidade Estadual de Feira de Santana, 44036-900 Feira de Santana, BA, Brazil.
authors: Danielle F
authors: DF
authors: Silva
authors: Departamento de Exatas, Universidade Estadual de Feira de Santana, 44036-900 Feira de Santana, BA, Brazil.
authors: Clayton Q
authors: CQ
authors: Alves
authors: Departamento de Saúde, Universidade Estadual de Feira de Santana, 44036-900 Feira de Santana, BA, Brazil. Electronic address: hugo@uefs.br.
authors: Hugo N
authors: HN
authors: Brandão
authors: Instituto de Química, Universidade Federal da Bahia, 40170-290 Salvador, BA, Brazil.
authors: Jorge M
authors: JM
authors: David
authors: Faculdade de Farmácia, Universidade Federal da Bahia, 40170-290 Salvador, BA, Brazil.
authors: Juceni P
authors: JP
authors: David
authors: Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, 14049-900 Ribeirão Preto, SP, Brazil.
authors: Rangel L
authors: RL
authors: Silva
authors: Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, 14049-900 Ribeirão Preto, SP, Brazil.
authors: Marcelo
authors: M
authors: Franchin
authors: Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, 14049-900 Ribeirão Preto, SP, Brazil.
authors: Thiago M
authors: TM
authors: Cunha
authors: Instituto de Química, Universidade Federal de Goiás, 74001-970 Goiânia, Go, Brazil.
authors: Felipe T
authors: FT
authors: Martins
authors: Instituto de Química, Universidade Federal de Goiás, 74001-970 Goiânia, Go, Brazil.
authors: Cecilia M A
authors: CM
authors: Oliveira
mesh_terms: D000818:Animals; D003374:Coumarins / Q000737:chemistry* / Q000302:isolation & purification; D015536:Down-Regulation; D015850:Interleukin-6 / Q000378:metabolism*; D017737:Macrophages, Peritoneal / Q000187:drug effects*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D015394:Molecular Structure; D016328:NF-kappa B / Q000378:metabolism; D035261:Plant Components, Aerial / Q000737:chemistry; D031801:Polygala / Q000737:chemistry*; D061251:Primary Cell Culture; D000067996:RAW 264.7 Cells; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism*
chemical_list: D003374:Coumarins; D015850:Interleukin-6; D016328:NF-kappa B; D014409:Tumor Necrosis Factor-alpha; C000613795:poligalen
keywords: Coumarin immune modulation; Cytokines; Polygala boliviensis; Polygalaceae