title: Lectin-like oxidized low-density lipoprotein receptor (LOX-1) in sickle cell disease vasculopathy.
abstract: Lectin-like oxidized low-density lipoprotein (LDL) receptor-1 (LOX-1) is an endothelial receptor for oxidized LDL. Increased expression of LOX-1 has been demonstrated in atherosclerotic lesions and diabetic vasculopathy. In this study, we investigate the expression of LOX-1 receptor in sickle cell disease (SCD) vasculopathy. Expression of LOX-1 in brain vascular endothelium is markedly increased and LOX-1 gene expression is upregulated in cultured human brain microvascular endothelial cells by incubation with SCD erythrocytes. Also, the level of circulating soluble LOX-1 concentration is elevated in the plasma of SCD patients. Increased LOX-1 expression in endothelial cells is potentially involved in the pathogenesis of SCD vasculopathy. Soluble LOX-1 concentration in SCD may provide a novel biomarker for risk stratification of sickle cell vascular complications.
authors: Department of Pathology and Laboratory Medicine, UC Davis Medical Center, Sacramento, CA, USA. Electronic address: myychen@ucdavis.edu.
authors: Mingyi
authors: M
authors: Chen
authors: Department of Pathology and Laboratory Medicine, UC Davis Medical Center, Sacramento, CA, USA.
authors: Hong
authors: H
authors: Qiu
authors: Department of Pathology and Laboratory Medicine, UC Davis Medical Center, Sacramento, CA, USA.
authors: Xin
authors: X
authors: Lin
authors: Department of Pathology and Laboratory Medicine, UC Davis Medical Center, Sacramento, CA, USA.
authors: David
authors: D
authors: Nam
authors: Department of Pathology and Laboratory Medicine, UC Davis Medical Center, Sacramento, CA, USA.
authors: Lucy
authors: L
authors: Ogbu-Nwobodo
authors: Department of Pathology and Laboratory Medicine, UC Davis Medical Center, Sacramento, CA, USA.
authors: Hannah
authors: H
authors: Archibald
authors: Department of Pathology and Laboratory Medicine, UC Davis Medical Center, Sacramento, CA, USA.
authors: Amelia
authors: A
authors: Joslin
authors: Department of Pathology and Laboratory Medicine, UC Davis Medical Center, Sacramento, CA, USA; Division of Hematology Oncology, UC Davis Medical Center, Sacramento, CA, USA.
authors: Ted
authors: T
authors: Wun
authors: Department of Physiology, Shinshu University School of Medicine, Matsumoto, Japan.
authors: Tatsuya
authors: T
authors: Sawamura
authors: Department of Pathology and Laboratory Medicine, UC Davis Medical Center, Sacramento, CA, USA. Electronic address: rgreen@ucdavis.edu.
authors: Ralph
authors: R
authors: Green
mesh_terms: D000293:Adolescent; D000328:Adult; D000755:Anemia, Sickle Cell / Q000150:complications*; D001800:Blood Specimen Collection; D001921:Brain / Q000473:pathology; D016022:Case-Control Studies; D002478:Cells, Cultured; D002648:Child; D042783:Endothelial Cells / Q000737:chemistry; D005260:Female; D005786:Gene Expression Regulation; D006801:Humans; D008077:Lipoproteins, LDL; D008297:Male; D008875:Middle Aged; D051127:Scavenger Receptors, Class E / Q000097:blood / Q000235:genetics / Q000502:physiology*; D014652:Vascular Diseases / Q000209:etiology*
chemical_list: D008077:Lipoproteins, LDL; C495137:OLR1 protein, human; D051127:Scavenger Receptors, Class E; C099252:oxidized low density lipoprotein
keywords: Adhesion molecule; Endothelium; Lectin-like oxidized low-density lipoprotein receptor (LOX-1); Sickle cell disease; Vasculopathy