title: Opposite Cannabis-Cognition Associations in Psychotic Patients Depending on Family History.
abstract: The objective of this study is to investigate cognitive performance in a first-episode psychosis sample, when stratifying the interaction by cannabis use and familial or non-familial psychosis. Hierarchical-regression models were used to analyse this association in a sample of 268 first-episode psychosis patients and 237 controls. We found that cannabis use was associated with worse working memory, regardless of family history. However, cannabis use was clearly associated with worse cognitive performance in patients with no family history of psychosis, in cognitive domains including verbal memory, executive function and global cognitive index, whereas cannabis users with a family history of psychosis performed better in these domains. The main finding of the study is that there is an interaction between cannabis use and a family history of psychosis in the areas of verbal memory, executive function and global cognition: that is, cannabis use is associated with a better performance in patients with a family history of psychosis and a worse performance in those with no family history of psychosis. In order to confirm this hypothesis, future research should explore the actual expression of the endocannabinoid system in patients with and without a family history of psychosis.
authors: Centre for Biomedical Research in the Mental Health Network (CIBERSAM), Madrid, Spain.|Department of Psychiatry, Araba University Hospital, University of the Basque Country, Vitoria, Spain.
authors: Ana
authors: A
authors: González-Pinto
authors: Centre for Biomedical Research in the Mental Health Network (CIBERSAM), Madrid, Spain.|Department of Psychiatry, Araba University Hospital, University of the Basque Country, Vitoria, Spain.
authors: Itxaso
authors: I
authors: González-Ortega
authors: Centre for Biomedical Research in the Mental Health Network (CIBERSAM), Madrid, Spain.|Department of Psychiatry, Araba University Hospital, University of the Basque Country, Vitoria, Spain.
authors: Susana
authors: S
authors: Alberich
authors: Centre for Biomedical Research in the Mental Health Network (CIBERSAM), Madrid, Spain.|Department of Psychiatry, Araba University Hospital, University of the Basque Country, Vitoria, Spain.
authors: Sonia
authors: S
authors: Ruiz de Azúa
authors: Centre for Biomedical Research in the Mental Health Network (CIBERSAM), Madrid, Spain.|Barcelona Clinic Schizophrenia Unit, Neuroscience Institute, Hospital Clinic of Barcelona, Barcelona, Spain.|Department of Psychiatry and Clinical Psychobiology, University of Barcelona. Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.
authors: Miguel
authors: M
authors: Bernardo
authors: Centre for Biomedical Research in the Mental Health Network (CIBERSAM), Madrid, Spain.|Barcelona Clinic Schizophrenia Unit, Neuroscience Institute, Hospital Clinic of Barcelona, Barcelona, Spain.
authors: Miquel
authors: M
authors: Bioque
authors: Centre for Biomedical Research in the Mental Health Network (CIBERSAM), Madrid, Spain.|Barcelona Clinic Schizophrenia Unit, Neuroscience Institute, Hospital Clinic of Barcelona, Barcelona, Spain.
authors: Bibiana
authors: B
authors: Cabrera
authors: Centre for Biomedical Research in the Mental Health Network (CIBERSAM), Madrid, Spain.|Department of Psychiatry, Institut d'Investigació Biomèdica-Sant Pau (IIB-SANT PAU), Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona (UAB), Barcelona, Spain.
authors: Iluminada
authors: I
authors: Corripio
authors: Centre for Biomedical Research in the Mental Health Network (CIBERSAM), Madrid, Spain.|Child and Adolescent Psychiatry Department. Gregorio Marañón General University Hospital. School of Medicine, Universidad Complutense, IiSGM, Madrid, Spain.
authors: Celso
authors: C
authors: Arango
authors: Centre for Biomedical Research in the Mental Health Network (CIBERSAM), Madrid, Spain.|University of Zaragoza, Zaragoza, Spain.|Aragon Institute for Health Sciences (IIS Aragón), Zaragoza, Spain.
authors: Antonio
authors: A
authors: Lobo
authors: Department of Psychiatry, Navarre Hospital Complex, Pamplona, Spain. IdiSNA, Navarre Institute for Health Research, Pamplona, Spain.
authors: Ana M
authors: AM
authors: Sánchez-Torres
authors: Department of Psychiatry, Navarre Hospital Complex, Pamplona, Spain. IdiSNA, Navarre Institute for Health Research, Pamplona, Spain.
authors: Manuel J
authors: MJ
authors: Cuesta
mesh_terms: D000328:Adult; D002188:Cannabis / Q000009:adverse effects*; D003071:Cognition / Q000187:drug effects*; D056344:Executive Function / Q000187:drug effects; D005260:Female; D006801:Humans; D008297:Male; D008570:Memory, Short-Term / Q000187:drug effects*; D009483:Neuropsychological Tests; D011618:Psychotic Disorders / Q000503:physiopathology / Q000523:psychology*