title: Measurement of transepidermal water loss (TEWL) in cats with experimental skin barrier dysfunction using a closed chamber system.
abstract: BACKGROUND
  A closed chamber evaporimeter is suitable for measuring transepidermal water loss (TEWL) in cats because of the compact device size, tolerance to sudden movement and short measuring time. TEWL is a representative parameter for skin barrier dysfunction, which is one of the clinical signs of atopic dermatitis in humans and dogs. Measurement of feline TEWL has been reported, but applicability of this parameter has not been validated.
  
  
  OBJECTIVE
  The aims of this study were to determine if tape stripping is a valid experimental model in cats for studying TEWL and to determine if a closed chambered system is a suitable measurement tool for cats.
  
  
  METHODS
  Ten clinically normal cats.
  
  
  METHODS
  In order to evaluate variation of the measured values, TEWL was measured at the right and left side of the three clipped regions (axillae, lateral thigh and groin). Subsequently, TEWL was measured using sequential tape stripping of the stratum corneum as a model of acute barrier disruption.
  
  
  RESULTS
  The variations between both sides of the three regions showed no significant difference. Sequential tape stripping was associated with increasing values for TEWL.
  
  
  CONCLUSIONS
  Feline TEWL was shown to reflect changes in the skin barrier in an experimental model using a closed chamber system and has the potential for evaluating skin barrier function in cats with skin diseases.
authors: School of Veterinary Nursing and Technology, Faculty of Veterinary Science, Nippon Veterinary and Life Science University, 1-7-1 Kyonancho, Musashino, Tokyo, 180-8602, Japan. momota@nvlu.ac.jp.
authors: Yutaka
authors: Y
authors: Momota
authors: School of Veterinary Nursing and Technology, Faculty of Veterinary Science, Nippon Veterinary and Life Science University, 1-7-1 Kyonancho, Musashino, Tokyo, 180-8602, Japan.
authors: Kenichiro
authors: K
authors: Shimada
authors: School of Veterinary Nursing and Technology, Faculty of Veterinary Science, Nippon Veterinary and Life Science University, 1-7-1 Kyonancho, Musashino, Tokyo, 180-8602, Japan.
authors: Azusa
authors: A
authors: Gin
authors: School of Veterinary Nursing and Technology, Faculty of Veterinary Science, Nippon Veterinary and Life Science University, 1-7-1 Kyonancho, Musashino, Tokyo, 180-8602, Japan.
authors: Takako
authors: T
authors: Matsubara
authors: School of Veterinary Nursing and Technology, Faculty of Veterinary Science, Nippon Veterinary and Life Science University, 1-7-1 Kyonancho, Musashino, Tokyo, 180-8602, Japan.
authors: Daigo
authors: D
authors: Azakami
authors: School of Veterinary Nursing and Technology, Faculty of Veterinary Science, Nippon Veterinary and Life Science University, 1-7-1 Kyonancho, Musashino, Tokyo, 180-8602, Japan.
authors: Katsumi
authors: K
authors: Ishioka
authors: Technical Information Centre, Kyoritsu Seiyaku Corporation, 1-12-4 Kudankita, Chiyoda-ku, Tokyo, 102-0073, Japan.
authors: Yuka
authors: Y
authors: Nakamura
authors: School of Veterinary Nursing and Technology, Faculty of Veterinary Science, Nippon Veterinary and Life Science University, 1-7-1 Kyonancho, Musashino, Tokyo, 180-8602, Japan.
authors: Toshinori
authors: T
authors: Sako
mesh_terms: D000818:Animals; D002415:Cats / Q000502:physiology*; D005260:Female; D008297:Male; D012879:Skin Physiological Phenomena; D014870:Water Loss, Insensible / Q000502:physiology*