title: Cost of rotavirus diarrhea for programmatic evaluation of vaccination in Vietnam.
abstract: Rotavirus is the most common etiology of diarrhea-associated hospitalizations and clinic visits in Vietnamese children < 5 years old. To estimate the economic burden of rotavirus-associated formal healthcare encounters, an economic study was conducted.
  
  
  
  A cost-of-illness study was performed from a societal perspective. Data were collected from children below the age of five years who presented to a clinic or hospital with symptoms of acute gastroenteritis (AGE). Patient-specific information on resource use and cost was obtained through caregiver interviews and medical chart review. Costs are presented in 2014 US dollar ($).
  
  
  
  A total of 557 children with symptoms of AGE were enrolled from March through June 2009, with mean age of 16.5 months. Of the 340 outpatients and 217 admitted patients enrolled, 41 % tested rotavirus positive. It was found that, from a societal perspective, the mean total cost of AGE was $175. Costs of patients with and without rotavirus were $217 and $158, respectively. From multiple regression analysis, it was found that rotavirus infection, patient age and receiving oral rehydration solution before visiting health facility had significant effect on the costs.
  
  
  
  This study clearly demonstrated substantial economic burden of AGE including rotavirus disease. They were significantly greater than the previously reported cost estimates in Vietnam. These updated costs of illness result in more favorable vaccine cost-effectiveness than in previous economic evaluations.
authors: Faculty of Pharmacy, Mahidol University, 447 Sri Ayutthaya Road, Ratchathevi, Bangkok, 10400, Thailand. arthorn.rie@mahidol.ac.th.
authors: Arthorn
authors: 0000-0003-2959-3244
authors: A
authors: Riewpaiboon
authors: MRC Tropical Epidemiology Group, London School of Hygiene & Tropical Medicine, London, UK.|International Vaccine Institute, Seoul, South Korea.
authors: Sunheang
authors: S
authors: Shin
authors: National Institute of Hygiene and Epidemiology, Hanoi, Vietnam.
authors: Thi Phuong Mai
authors: TP
authors: Le
authors: National Institute of Hygiene and Epidemiology, Hanoi, Vietnam.
authors: Dinh Thiem
authors: DT
authors: Vu
authors: National Institute of Hygiene and Epidemiology, Hanoi, Vietnam.
authors: Thi Hien Anh
authors: TH
authors: Nguyen
authors: MRC Tropical Epidemiology Group, London School of Hygiene & Tropical Medicine, London, UK.
authors: Neal
authors: N
authors: Alexander
authors: National Institute of Hygiene and Epidemiology, Hanoi, Vietnam.
authors: Duc Anh
authors: DA
authors: Dang
mesh_terms: D017281:Cost of Illness; D003967:Diarrhea / Q000191:economics* / Q000517:prevention & control / Q000821:virology; D005260:Female; D005759:Gastroenteritis / Q000191:economics* / Q000517:prevention & control / Q000821:virology; D006760:Hospitalization / Q000706:statistics & numerical data; D006801:Humans; D007223:Infant; D008297:Male; D012401:Rotavirus; D012400:Rotavirus Infections / Q000191:economics* / Q000517:prevention & control / Q000821:virology; D022243:Rotavirus Vaccines / Q000191:economics; D014611:Vaccination / Q000191:economics*; D014744:Vietnam
chemical_list: D022243:Rotavirus Vaccines
keywords: Acute gastroenteritis; Cost of illness; Rotavirus burden; Vietnam