title: Population Polymorphism of IFNL3 and IFNL4 Genes of Type 3 Interferon Associated with Spontaneous Clearance of Hepatitis C Virus in Representatives of Caucasian and Mongoloid Races.
abstract: The frequency of single nucleotide polymorphisms of IFNL3 gene (rsl12979860 and rs8099917) and dinucleotide polymorphism of IFNL4 gene (ss469415590) were estimated in healthy inhabitants of Mongolia and Irkutsk regions taking into account their races. Population and genetic studies were performed in 1520 conventionally healthy volunteers (blood donors), representatives of Caucasian and Mongoloid races. Significant race-related differences in the incidence of IFNL3 and IFNL4 gene polymorphisms associated with spontaneous clearance of hepatitis C virus were found in healthy volunteers.
authors: Irkutsk State Medical University, Irkutsk, Russia.
authors: I V
authors: IV
authors: Malov
authors: Irkutsk State Medical University, Irkutsk, Russia. sikolesnikov2012@gmail.com.
authors: S I
authors: SI
authors: Malov
authors: Research Center of Problems of Family Health and Human Reproduction, Irkutsk, Russia.|Irkutsk State Medical Academy of Post-Graduate Education, Irkutsk, Russia.
authors: E D
authors: ED
authors: Savilov
authors: National Center of Investigation of Infectious Diseases, Ulan-Bator, Mongolia.
authors: D
authors: D
authors: Gantulga
authors: Irkutsk State Medical University, Irkutsk, Russia.
authors: L A
authors: LA
authors: Stepanenko
authors: Research Center of Problems of Family Health and Human Reproduction, Irkutsk, Russia.|Irkutsk State Medical Academy of Post-Graduate Education, Irkutsk, Russia.
authors: O B
authors: OB
authors: Ogarkov
authors: National Center of Investigation of Infectious Diseases, Ulan-Bator, Mongolia.
authors: D
authors: D
authors: Nyamkhuu
authors: Irkutsk State Medical University, Irkutsk, Russia.
authors: K A
authors: KA
authors: Aitov
authors: National Center of Investigation of Infectious Diseases, Ulan-Bator, Mongolia.
authors: P
authors: P
authors: Nyamdawa
authors: Research Center of Problems of Family Health and Human Reproduction, Irkutsk, Russia.
authors: S I
authors: SI
authors: Kolesnikov
mesh_terms: D044466:Asian People; D020022:Genetic Predisposition to Disease / Q000235:genetics; D005838:Genotype; D064368:Healthy Volunteers; D016174:Hepacivirus / Q000472:pathogenicity*; D006801:Humans; D007372:Interferons; D007378:Interleukins / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D044465:White People; D000095022:Interferon Lambda
chemical_list: D007372:Interferons; D007378:Interleukins; C000624353:interferon-lambda, human; D000095022:Interferon Lambda; C579163:IFNL4 protein, human
keywords: Caucasians; IFNL3; IFNL4; Mongoloids; genetic polymorphism