title: [ARID1A expression of SWI/SNF remodeling complex in pancreatic neuroendocrine tumor].
abstract: OBJECTIVE
  To study ARID1A expression and its role in pancreatic neuroendocrine tumors.
  
  
  METHODS
  51 cases of pancreatic neuroendocrine tumors were collected from July 2003 to May 2012 from Peking Union Medical College Hospital.Eighteen normal pancreatic tissues were used as positive control. HE staining method was used to observe general clinicopathological features. ARID1A expression was detected immunohistochemically by EnVision method. The relationship between ARID1A expression and tumor grade and stage was analyzed.
  
  
  RESULTS
  The level of ARID1A expression was not associated with patients' gender, age, TNM stage, and tumor size (P>0.05); but showed significantly negative correlation with tumor grade (P<0.05).
  
  
  CONCLUSIONS
  Low ARID1A expression was significantly related to the high grade level of pancreatic neuroendocrine tumors. It has a certain effect on the clinical classification of pancreatic neuroendocring tumors. ARID1A may play a role as a tumor suppressor gene.
authors: Department of Pathology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Science, Beijing 100730, China.
authors: L
authors: L
authors: Zhang
authors: C W
authors: CW
authors: Jia
authors: Z H
authors: ZH
authors: Lu
authors: J
authors: J
authors: Chen
mesh_terms: D004268:DNA-Binding Proteins; D006801:Humans; D009363:Neoplasm Proteins / Q000378:metabolism*; D018358:Neuroendocrine Tumors / Q000378:metabolism* / Q000473:pathology; D009687:Nuclear Proteins / Q000378:metabolism*; D010190:Pancreatic Neoplasms / Q000378:metabolism* / Q000473:pathology; D014157:Transcription Factors / Q000378:metabolism*
chemical_list: C112476:ARID1A protein, human; D004268:DNA-Binding Proteins; D009363:Neoplasm Proteins; D009687:Nuclear Proteins; D014157:Transcription Factors