title: The Interaction of TXNIP and AFq1 Genes Increases the Susceptibility of Schizophrenia.
abstract: Although previous studies showed the reduced risk of cancer in patients with schizophrenia, whether patients with schizophrenia possess genetic factors that also contribute to tumor suppressor is still unknown. In the present study, based on our previous microarray data, we focused on the tumor suppressor genes TXNIP and AF1q, which differentially expressed in patients with schizophrenia. A total of 413 patients and 578 healthy controls were recruited. We found no significant differences in genotype, allele, or haplotype frequencies at the selected five single nucleotide polymorphisms (SNPs) (rs2236566 and rs7211 in TXNIP gene; rs10749659, rs2140709, and rs3738481 in AF1q gene) between patients with schizophrenia and controls. However, we found the association between the interaction of TXNIP and AF1q with schizophrenia by using the MDR method followed by traditional statistical analysis. The best gene-gene interaction model identified was a three-locus model TXNIP (rs2236566, rs7211)-AF1q (rs2140709). After traditional statistical analysis, we found the high-risk genotype combination was rs2236566 (GG)-rs7211(CC)-rs2140709(CC) (OR = 1.35 [1.03-1.76]). The low-risk genotype combination was rs2236566 (GT)-rs7211(CC)-rs2140709(CC) (OR = 0.67 [0.49-0.91]). Our finding suggested statistically significant role of interaction of TXNIP and AF1q polymorphisms (TXNIP-rs2236566, TXNIP-rs7211, and AF1q-rs2769605) in schizophrenia susceptibility.
authors: Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
authors: Yousong
authors: Y
authors: Su
authors: Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.|Shanghai Key Laboratory of Psychotic Disorders, Shanghai, China.
authors: Wenhua
authors: W
authors: Ding
authors: Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
authors: Mengjuan
authors: M
authors: Xing
authors: Faculty of Medicine, Memorial University of Newfoundland, St. John's, NL, Canada.
authors: Dake
authors: D
authors: Qi
authors: Shanghai Key Laboratory of Psychotic Disorders, Shanghai, China. biolpschiatry@126.com.|Department of Neurology, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. biolpschiatry@126.com.
authors: Zezhi
authors: Z
authors: Li
authors: Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China. manyucc@126.com.|Shanghai Key Laboratory of Psychotic Disorders, Shanghai, China. manyucc@126.com.|Key Laboratory of Translational Psychiatry, Shanghai Jiao Tong University School of Medicine, Shanghai, China. manyucc@126.com.|Bio-X Institutes, Shanghai Jiao Tong University, Shanghai, China. manyucc@126.com.
authors: Donghong
authors: D
authors: Cui
mesh_terms: D000328:Adult; D000483:Alleles; D002352:Carrier Proteins / Q000235:genetics*; D016022:Case-Control Studies; D004843:Epistasis, Genetic; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006239:Haplotypes; D006801:Humans; D015810:Linkage Disequilibrium / Q000235:genetics; D008297:Male; D008957:Models, Genetic; D058011:Multifactor Dimensionality Reduction; D009363:Neoplasm Proteins / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D011518:Proto-Oncogene Proteins / Q000235:genetics*; D012307:Risk Factors; D012559:Schizophrenia / Q000235:genetics*
chemical_list: D002352:Carrier Proteins; C091736:MLLT11 protein, human; D009363:Neoplasm Proteins; D011518:Proto-Oncogene Proteins; C486715:TXNIP protein, human
keywords: AFq1; Interaction; Schizophrenia; TXNIP