title: Phenolic constituents from Wissadula periplocifolia (L.) C. Presl. and anti-inflammatory activity of 7,4'-di-O-methylisoscutellarein.
abstract: This study reports the first phenolics from Wissadula genus (Malvaceae) and the anti-inflammatory activity of 7,4'-di-O-methylisoscutellarein. Using chromatographic methods, five phenolic compounds were isolated from aerial parts of Wissadula periplocifolia (L.) C. Presl. The compounds were identified as 4-hydroxybenzoic acid, 3-hydroxybenzoic acid, trans-cinnamic acid, tamgermanetin and 7,4'-di-O-methylisoscutellarein using spectroscopic methods. The flavone 7,4'-di-O-methylisoscutellarein showed anti-inflammatory activity by inhibiting neutrophils recruitment in a mice model of pleurisy and by decreasing significantly the production of cytokines IL-1β and TNF-α.
authors: a Pós-graduação em Desenvolvimento e Inovação Tecnológica em Medicamentos, Centro de Ciências da Saúde , Universidade Federal da Paraíba , João Pessoa , Brazil.
authors: Yanna C F
authors: YC
authors: Teles
authors: b Faculdade Leão Sampaio, FLS , Juazeiro do Norte , Brazil.
authors: Jaime
authors: J
authors: Ribeiro-Filho
authors: c Instituto Oswaldo Cruz , FIOCRUZ , Rio de Janeiro , Brazil.
authors: Patrícia T
authors: PT
authors: Bozza
authors: d Centro de Biotecnologia , Universidade Federal da Paraíba , João Pessoa , Brazil.
authors: Maria de Fátima
authors: Mde F
authors: Agra
authors: e Strathclyde Institute of Pharmacy and Biomedical Sciences , University of Strathclyde , Glasgow , UK.
authors: Weam
authors: W
authors: Siheri
authors: e Strathclyde Institute of Pharmacy and Biomedical Sciences , University of Strathclyde , Glasgow , UK.
authors: John O
authors: JO
authors: Igoli
authors: e Strathclyde Institute of Pharmacy and Biomedical Sciences , University of Strathclyde , Glasgow , UK.
authors: Alexander I
authors: AI
authors: Gray
authors: a Pós-graduação em Desenvolvimento e Inovação Tecnológica em Medicamentos, Centro de Ciências da Saúde , Universidade Federal da Paraíba , João Pessoa , Brazil.
authors: Maria de Fátima V de
authors: Mde F
authors: Souza
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry* / Q000494:pharmacology*; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical / Q000379:methods; D047309:Flavones; D062385:Hydroxybenzoates / Q000494:pharmacology; D008297:Male; D019660:Malvaceae / Q000737:chemistry*; D008810:Mice, Inbred C57BL; D015394:Molecular Structure; D009504:Neutrophils / Q000187:drug effects / Q000473:pathology; D010226:Parabens / Q000494:pharmacology; D010636:Phenols / Q000737:chemistry / Q000494:pharmacology; D035261:Plant Components, Aerial / Q000737:chemistry; D010998:Pleurisy / Q000188:drug therapy / Q000378:metabolism; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
chemical_list: C000618874:7,4'-di-O-methylisoscutellarein; D000894:Anti-Inflammatory Agents, Non-Steroidal; D047309:Flavones; D062385:Hydroxybenzoates; D010226:Parabens; D010636:Phenols; D014409:Tumor Necrosis Factor-alpha; C032948:3-hydroxybenzoic acid; C038193:4-hydroxybenzoic acid
keywords: 7,4′-di-O-methylisoscutellarein; Malvaceae; Wissadula periplocifolia; anti-inflammatory activity