title: Investigation of ischemia-modified albumin levels and some atherosclerosis-related serum parameters in patients with diabetic foot.
abstract: OBJECTIVE
  To investigate serum ischemia-modified albumin (IMA), oxidized low-density lipoprotein (ox-LDL) levels, and paraoxonase 1 (PON1) activity in patients with diabetic foot.
  
  
  METHODS
  Thirty patients with diabetes mellitus (DM), 30 patients with diabetic foot (29 and 27 of these patients had type 2 DM, respectively), and 30 healthy volunteers as the control group were included in the study. The patients with diabetic foot were divided into 2 groups, as those who had or had not undergone lower extremity amputation. Serum PON1 activity, ox-LDL, and IMA levels were measured.
  
  
  RESULTS
  Serum PON1 activity was lower (P < 0.05) and ox-LDL levels were higher (P < 0.05) in the diabetic foot group than in the control and diabetes groups. Albumin-adjusted IMA values were higher (P < 0.001) in the diabetic foot group compared to the diabetes group. The postamputation levels of IMA were decreased compared to the preamputation condition (P < 0.05).
  
  
  CONCLUSIONS
  The low activity of PON1 and the high levels of ox-LDL and IMA may play an important role in the pathogenesis of diabetic foot. The use of these parameters in the follow-up of patients with DM may prevent the development of diabetic foot. In order to reach a definitive judgment, further studies with a larger number of subjects are necessary.
authors: Department of Biochemistry, Faculty of Medicine, Erciyes University, Kayseri, Turkey.
authors: Sabahattin
authors: S
authors: Muhtaroğlu
authors: Department of Biochemistry, Sivas Numune Hospital, Sivas, Turkey.
authors: Didem
authors: D
authors: Barlak Keti
authors: Department of Endocrinology, Faculty of Medicine, Erciyes University, Kayseri, Turkey.
authors: Kürşad
authors: K
authors: Ünlühizarci
mesh_terms: D043303:Aryldialkylphosphatase; D050197:Atherosclerosis; D015415:Biomarkers; D003924:Diabetes Mellitus, Type 2; D017719:Diabetic Foot; D006801:Humans; D008077:Lipoproteins, LDL; D012709:Serum Albumin
chemical_list: D015415:Biomarkers; D008077:Lipoproteins, LDL; D012709:Serum Albumin; D043303:Aryldialkylphosphatase; C468406:PON1 protein, human
keywords: Diabetic foot; ischemia-modified albumin; oxidized low-density lipoprotein; paraoxonase 1; peripheral arterial disease