title: Limb ischemia, an alarm signal to a thromboembolic cascade - renal infarction and nephrectomy followed by surgical suppression of the left atrial appendage.
abstract: We present the case of a 55-year-old male with mild hypertension and brief episodes of paroxysmal self-limiting atrial fibrillation (AF) since 2010. Despite a small cardioembolic risk score, CHA2DS2-Vasc=1 (Congestive heart failure, Hypertension, Age=75, Diabetes melitus, prior Stroke), the patient is effectively anticoagulated using acenocumarol. In December 2014, he showed signs of plantar transitory ischemia, for which he did not address the doctor. In early January 2015, he urgently presented at the hospital with left renal pain, caused by a renal infarction, diagnosed by computed tomography (CT) angiography. Left nephrectomy was performed with pathological confirmation. He was discharged with effective anticoagulation treatment. Within the next two weeks, he suffered a transitory ischemic event and a stroke, associated with right sided hemiparesis. On admission, AF was found and converted to sinus rhythm with effective anticoagulation - international normalized ratio (INR) of 2.12. Transthoracic echocardiography detected no pathological findings. Transesophageal echocardiography showed an expended left atrial appendage (LAA) with a slow blood flow (0.2 m÷s) and spontaneous echocontrast. Considering these clinical circumstances, surgical LAA suppression was decided on as a last therapeutic resort. Postoperative evolution was favorable; the patient is still free of ischemic events, one year post-intervention. Some morphological and hemodynamic characteristics of LAA may add additional thromboembolic risk factors, not included in scores. Removing them by surgical LAA suppression may decrease the risk of cardioembolic events. Intraoperative presence of thrombus makes it an indisputable proof.
authors: Department of Forensic Medicine, University of Medicine and Pharmacy of Tirgu Mures, Romania; cosmincarasca@yahoo.com.
authors: Cosmin
authors: C
authors: Caraşca
authors: Angela
authors: A
authors: Borda
authors: Alexandru
authors: A
authors: Incze
authors: Emilian
authors: E
authors: Caraşca
authors: Attila
authors: A
authors: Frigy
authors: HoraŢiu
authors: H
authors: Suciu
mesh_terms: D020517:Atrial Appendage / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery*; D004617:Embolism / Q000150:complications* / Q000000981:diagnostic imaging / Q000473:pathology; D005121:Extremities / Q000098:blood supply* / Q000473:pathology; D006801:Humans; D007238:Infarction / Q000150:complications* / Q000000981:diagnostic imaging / Q000473:pathology; D007511:Ischemia / Q000150:complications* / Q000000981:diagnostic imaging / Q000473:pathology; D007668:Kidney / Q000098:blood supply* / Q000473:pathology / Q000601:surgery; D008297:Male; D008875:Middle Aged; D009206:Myocardium / Q000473:pathology; D009336:Necrosis; D009392:Nephrectomy; D013927:Thrombosis / Q000150:complications* / Q000000981:diagnostic imaging / Q000473:pathology; D014057:Tomography, X-Ray Computed