title: KDM4B plays an important role in mitochondrial apoptosis by upregulating HAX1 expression in colorectal cancer.
abstract: Histone methyltransferases and demethylases regulate transcription by altering the epigenetic marks on histones in tumorigenesis. Members of the histone lysine(K)-specific demethylase 4 (KDM4) family are dysregulated in several types of cancer. Here, we report a novel role for KDM4B in mitochondrial apoptosis. In this study, we demonstrate that KDM4B is overexpressed in colorectal cancer (CRC) tissues. Decreased expression of KDM4B significantly promoted apoptosis of CRC cell lines. Moreover, our data indicate that HAX1 is required for KDM4B-mediated mitochondrial apoptosis. The transcription of HAX1 was directly activated by KDM4B. We also show that HAX1 is overexpressed in CRC tissues and is positively correlated with KMD4B expression. Collectively, we demonstrate that KDM4B may play an important role in mitochondrial apoptosis and represent a potential therapeutic cancer target in CRC.
authors: Cancer Research Institute, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, China.
authors: Haijie
authors: H
authors: Li
authors: Cancer Research Institute, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, China.
authors: Xi
authors: X
authors: Yang
authors: Cancer Research Institute, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, China.
authors: Guihua
authors: G
authors: Wang
authors: Cancer Research Institute, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, China.
authors: Xiaolan
authors: X
authors: Li
authors: Cancer Research Institute, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, China.
authors: Deding
authors: D
authors: Tao
authors: Cancer Research Institute, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, China.
authors: Junbo
authors: J
authors: Hu
authors: Cancer Research Institute, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, China.
authors: Xuelai
authors: X
authors: Luo
mesh_terms: D048868:Adaptor Proteins, Signal Transducing / Q000378:metabolism*; D000818:Animals; D017209:Apoptosis; D045744:Cell Line, Tumor; D002470:Cell Survival; D015179:Colorectal Neoplasms / Q000378:metabolism* / Q000473:pathology; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D056484:Jumonji Domain-Containing Histone Demethylases / Q000378:metabolism*; D051379:Mice; D008819:Mice, Nude; D008928:Mitochondria / Q000378:metabolism*; D009368:Neoplasm Transplantation; D034622:RNA Interference; D012333:RNA, Messenger / Q000378:metabolism; D015533:Transcriptional Activation
chemical_list: D048868:Adaptor Proteins, Signal Transducing; C104759:HAX1 protein, human; D012333:RNA, Messenger; D056484:Jumonji Domain-Containing Histone Demethylases; C523637:KDM4B protein, human
keywords: HAX1; KDM4B; colorectal cancer; mitochondrial apoptosis