title: New repellent effective against African malaria mosquito Anopheles gambiae: implications for vector control.
abstract: Anopheles gambiae Giles sensu stricto (Diptera: Culicidae) is a vector for Plasmodium, the causative agent of malaria. Current control strategies to reduce the impact of malaria focus on reducing the frequency of mosquito attacks on humans, thereby decreasing Plasmodium transmission. A need for new repellents effective against Anopheles mosquitoes has arisen because of changes in vector behaviour as a result of control strategies and concern over the health impacts of current repellents. The response of A. gambiae to potential repellents was investigated through an electroantennogram screen and the most promising of these candidates (1-allyloxy-4-propoxybenzene, 3c{3,6}) chosen for behavioural testing. An assay to evaluate the blood-host seeking behaviour of A. gambiae towards a simulated host protected with this repellent was then performed. The compound 3c{3,6} was shown to be an effective repellent, causing mosquitoes to reduce their contact with a simulated blood-host and probe less at the host odour. Thus, 3c{3,6} may be an effective repellent for the control of A. gambiae.
authors: Department of Biology, University of Victoria, Victoria, British Columbia, Canada. hodson.christina@gmail.com.|Department of Biological Sciences, Simon Fraser University, Burnaby, British Columbia, Canada. hodson.christina@gmail.com.
authors: C N
authors: CN
authors: Hodson
authors: Department of Chemistry, Simon Fraser University, Burnaby, British Columbia, Canada.
authors: Y
authors: Y
authors: Yu
authors: Department of Chemistry, Simon Fraser University, Burnaby, British Columbia, Canada.
authors: E
authors: E
authors: Plettner
authors: Department of Biological Sciences, Simon Fraser University, Burnaby, British Columbia, Canada.
authors: B D
authors: BD
authors: Roitberg
mesh_terms: D000818:Animals; D000852:Anopheles / Q000502:physiology; D005247:Feeding Behavior; D005260:Female; D007302:Insect Repellents; D008288:Malaria / Q000517:prevention & control*; D009032:Mosquito Control; D000072138:Mosquito Vectors
chemical_list: D007302:Insect Repellents
keywords: 1-Allyloxy-4-propoxybenzene; Culicidae; DEET; disease ecology; foraging behaviour