title: Aortic aneurysm associated with rheumatoid arthritis: a population-based cross-sectional study.
abstract: There is substantial evidence that aortic aneurysm (AA) may be a manifestation of several systemic rheumatic disorders. However, only several studies have assessed the association between rheumatoid arthritis (RA) and AA. The aim of this study was to evaluate the incidence of AA in RA patients in a case-control study. A retrospective case-control study was performed utilizing the database of Clalit Health Services (CHS), a large healthcare provider organization in Israel. Data available from the CHS database included age, sex, socioeconomic status (SES), and diagnoses of chronic diseases, including AA. Patients over the age of 20 years who were diagnosed with RA ("cases") were compared with a sample of age- and gender-matched enrollees without RA ("controls") regarding the prevalence of AA. Chi-square and t tests were used for univariate analysis, and a logistic regression model was used for multivariate analysis. The study included 11,782 RA patients and 57,973 age- and gender-matched controls. The proportion of AA was significantly higher in RA patients (0.72 %) compared to the control group 0.49 % (odds ratio (OR) 1.48, 95 %; confidence interval (CI) 1.15-1.88; p = 0.002). A multivariate analysis that evaluated covariates associated with AA revealed an independent association of AA and RA after adjustment for different factors including age, gender, SES, and smoking status (OR 1.406, 95 %; CI 1.094-1.789; p = 0.006). Our study has demonstrated that AA is more prevalent in patients with RA in comparison with general population. Future large randomized studies are important to identify cardiovascular- and disease-related risk factors for AA formation in RA patients.
authors: Department of Medicine "B," Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Tel-Hashomer, Israel, Sackler Faculty of Medicine, Tel-Aviv University, 5262100, Tel-Hashomer, Israel.
authors: Ora
authors: O
authors: Shovman
authors: Department of Medicine "B," Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Tel-Hashomer, Israel, Sackler Faculty of Medicine, Tel-Aviv University, 5262100, Tel-Hashomer, Israel.
authors: Shmuel
authors: S
authors: Tiosano
authors: Chief Physician's Office, Clalit Health Services, Tel Aviv, Israel.
authors: Doron
authors: D
authors: Comaneshter
authors: Chief Physician's Office, Clalit Health Services, Tel Aviv, Israel.|Siaal Research Center for Family Medicine and Primary Care, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel.
authors: Arnon D
authors: AD
authors: Cohen
authors: Department of Medicine "B," Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Tel-Hashomer, Israel, Sackler Faculty of Medicine, Tel-Aviv University, 5262100, Tel-Hashomer, Israel. howard.amital@sheba.health.gov.il.
authors: Howard
authors: H
authors: Amital
authors: Central Management, Clalit Health Services, Tel Aviv, Israel.|Department Of Public Health, Faculty Of Health Sciences, Ben-Gurion University Of Negev, Beer Sheva, Israel.
authors: Michael
authors: M
authors: Sherf
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D001014:Aortic Aneurysm / Q000453:epidemiology*; D001172:Arthritis, Rheumatoid / Q000453:epidemiology*; D016022:Case-Control Studies; D015897:Comorbidity; D003430:Cross-Sectional Studies; D016208:Databases, Factual; D005260:Female; D006801:Humans; D015994:Incidence; D007557:Israel / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D012189:Retrospective Studies; D012307:Risk Factors; D012737:Sex Factors; D012907:Smoking
keywords: Aortic aneurysm; Atherosclerosis; Autoimmune disease; Rheumatoid arthritis