title: Determinants in Adolescence of Stroke-Related Hospital Stay Duration in Men: A National Cohort Study.
abstract: Physical and psychological characteristics in adolescence are associated with subsequent stroke risk. Our aim is to investigate their relevance to length of hospital stay and risk of second stroke.
  
  
  
  Swedish men born between 1952 and 1956 (n=237 879) were followed from 1987 to 2010 using information from population-based national registers. Stress resilience, body mass index, cognitive function, physical fitness, and blood pressure were measured at compulsory military conscription examinations in late adolescence. Joint Cox proportional hazards models estimated the associations of these characteristics with long compared with short duration of stroke-related hospital stay and with second stroke compared with first.
  
  
  
  Some 3000 men were diagnosed with nonfatal stroke between ages 31 and 58 years. Low stress resilience, underweight, and higher systolic blood pressure (per 1-mm Hg increase) during adolescence were associated with longer hospital stay (compared with shorter) in ischemic stroke, with adjusted relative hazard ratios (and 95% confidence intervals) of 1.46 (1.08-1.89), 1.41 (1.04-1.91), and 1.01 (1.00-1.02), respectively. Elevated systolic and diastolic blood pressures during adolescence were associated with longer hospital stay in men with intracerebral hemorrhage: 1.01 (1.00-1.03) and 1.02 (1.00-1.04), respectively. Among both stroke types, obesity in adolescence conferred an increased risk of second stroke: 2.06 (1.21-3.45).
  
  
  
  Some characteristics relevant to length of stroke-related hospital stay and risk of second stroke are already present in adolescence. Early lifestyle influences are of importance not only to stroke risk by middle age but also to recurrence and use of healthcare resources among stroke survivors.
authors: From the Clinical Epidemiology and Biostatistics (C.B., R.U., K.F., S.M.) and Department of Neurology (P.A.), School of Medical Sciences, Örebro University, Sweden; Clinical Epidemiology Unit, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden (S.M.); and Department of Epidemiology and Public Health, University College London, United Kingdom (S.M.). cecilia.bergh@oru.se.
authors: Cecilia
authors: C
authors: Bergh
authors: From the Clinical Epidemiology and Biostatistics (C.B., R.U., K.F., S.M.) and Department of Neurology (P.A.), School of Medical Sciences, Örebro University, Sweden; Clinical Epidemiology Unit, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden (S.M.); and Department of Epidemiology and Public Health, University College London, United Kingdom (S.M.).
authors: Ruzan
authors: R
authors: Udumyan
authors: From the Clinical Epidemiology and Biostatistics (C.B., R.U., K.F., S.M.) and Department of Neurology (P.A.), School of Medical Sciences, Örebro University, Sweden; Clinical Epidemiology Unit, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden (S.M.); and Department of Epidemiology and Public Health, University College London, United Kingdom (S.M.).
authors: Peter
authors: P
authors: Appelros
authors: From the Clinical Epidemiology and Biostatistics (C.B., R.U., K.F., S.M.) and Department of Neurology (P.A.), School of Medical Sciences, Örebro University, Sweden; Clinical Epidemiology Unit, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden (S.M.); and Department of Epidemiology and Public Health, University College London, United Kingdom (S.M.).
authors: Katja
authors: K
authors: Fall
authors: From the Clinical Epidemiology and Biostatistics (C.B., R.U., K.F., S.M.) and Department of Neurology (P.A.), School of Medical Sciences, Örebro University, Sweden; Clinical Epidemiology Unit, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden (S.M.); and Department of Epidemiology and Public Health, University College London, United Kingdom (S.M.).
authors: Scott
authors: S
authors: Montgomery
mesh_terms: D000293:Adolescent; D000328:Adult; D001794:Blood Pressure / Q000502:physiology*; D006801:Humans; D007902:Length of Stay; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000150:complications*; D012042:Registries; D055500:Resilience, Psychological; D012307:Risk Factors; D020521:Stroke / Q000209:etiology / Q000628:therapy*; D013548:Sweden; D013851:Thinness / Q000150:complications*
keywords: adolescent; blood pressure; length of stay; psychological stress; risk factors