title: Background Colonic 18F-Fluoro-2-Deoxy-D-Glucose Uptake on Positron Emission Tomography Is Associated with the Presence of Colorectal Adenoma.
abstract: 18F-fluoro-2-deoxy-D-glucose (FDG) positron emission tomography (PET) scan is used to evaluate various kinds of tumors. While most studies on PET findings of the colon focus on the colonic uptake pattern, studies regarding background colonic uptake on PET scan are rare. The purpose of this study was to identify the association between the background colonic uptake and the presence of colorectal adenoma (CRA), which is a frequent precancerous lesion. We retrospectively reviewed the medical records of 241 patients with gynecologic malignancy who had received PET or PET/computed tomography (CT) scan and colonoscopy at the same period as a baseline evaluation. Background colonic 18F-FDG uptake was visually graded and the maximal standardized uptake values (SUVmax) of 7 different bowel segments were averaged. In univariate analysis, older age at diagnosis (≥ 50 years, p = 0.034), overweight (BMI ≥ 23 kg/m², p = 0.010), hypercholesterolemia (≥ 200 mg/dL, p = 0.027), and high grade background colonic uptake (p = 0.009) were positively associated with the prevalence of CRA. By multiple logistic regression, high grade background colonic uptake was independently predictive of CRA (odds ratio = 2.25, p = 0.021). The proportion of CRA patients significantly increased as background colonic uptake grade increased from 1 to 4 (trend p = 0.015). Out of the 138 patients who underwent PET/CT, the proportion of CRA patients in the group with high SUVmax (> 2.25) was significantly higher than in the low SUVmax group (27.5% vs. 11.6%, p = 0.031). In conclusion, high grade of background colonic 18F-FDG uptake is significantly associated with the prevalence of CRA.
authors: Department of Internal Medicine, School of Medicine, Ewha Womans University, Seoul, Republic of Korea.
authors: Ko Eun
authors: KE
authors: Lee
authors: Department of Internal Medicine, School of Medicine, Ewha Womans University, Seoul, Republic of Korea.
authors: Chang Mo
authors: CM
authors: Moon
authors: Department of Nuclear Medicine, School of Medicine, Ewha Womans University, Seoul, Republic of Korea.
authors: Hai-Jeon
authors: HJ
authors: Yoon
authors: Department of Nuclear Medicine, School of Medicine, Ewha Womans University, Seoul, Republic of Korea.
authors: Bom Sahn
authors: BS
authors: Kim
authors: Department of Internal Medicine, School of Medicine, Ewha Womans University, Seoul, Republic of Korea.
authors: Ji Young
authors: JY
authors: Chang
authors: Department of Internal Medicine, School of Medicine, Ewha Womans University, Seoul, Republic of Korea.
authors: Hyo Moon
authors: HM
authors: Son
authors: Department of Internal Medicine, School of Medicine, Ewha Womans University, Seoul, Republic of Korea.
authors: Min Sun
authors: MS
authors: Ryu
authors: Department of Internal Medicine, School of Medicine, Ewha Womans University, Seoul, Republic of Korea.
authors: Seong-Eun
authors: SE
authors: Kim
authors: Department of Internal Medicine, School of Medicine, Ewha Womans University, Seoul, Republic of Korea.
authors: Ki-Nam
authors: KN
authors: Shim
authors: Department of Internal Medicine, School of Medicine, Ewha Womans University, Seoul, Republic of Korea.
authors: Hye-Kyung
authors: HK
authors: Jung
authors: Department of Internal Medicine, School of Medicine, Ewha Womans University, Seoul, Republic of Korea.
authors: Sung-Ae
authors: SA
authors: Jung
mesh_terms: D000236:Adenoma / Q000175:diagnosis / Q000000981:diagnostic imaging* / Q000473:pathology; D000328:Adult; D000368:Aged; D003113:Colonoscopy; D015179:Colorectal Neoplasms / Q000175:diagnosis / Q000000981:diagnostic imaging* / Q000473:pathology; D005260:Female; D019788:Fluorodeoxyglucose F18 / Q000493:pharmacokinetics*; D006801:Humans; D008875:Middle Aged; D000072078:Positron Emission Tomography Computed Tomography; D049268:Positron-Emission Tomography / Q000379:methods*; D019275:Radiopharmaceuticals / Q000493:pharmacokinetics*; D012189:Retrospective Studies
chemical_list: D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18