title: Solid-Phase Synthesis of Cyclic Depsipeptides Containing a Tyrosine Phenyl Ester Bond.
abstract: The first solid-phase strategy for the synthesis of cyclic depsipeptides containing a phenyl ester linkage in their structure is described. The key steps of the synthesis were the formation of the phenyl ester bond and the on-resin head-to-side-chain cyclization. The amino acid configuration significantly influenced the formation and the stability of the cyclic depsipeptides. The presence of a l-Tyr(1) and a d-Tyr(7) led to the most stable sequences.
authors: LIPPSO, Department of Chemistry, University of Girona , Maria Aurèlia Capmany 69, 17003 Girona, Spain.
authors: Cristina
authors: C
authors: Rosés
authors: LIPPSO, Department of Chemistry, University of Girona , Maria Aurèlia Capmany 69, 17003 Girona, Spain.
authors: Cristina
authors: C
authors: Camó
authors: LIPPSO, Department of Chemistry, University of Girona , Maria Aurèlia Capmany 69, 17003 Girona, Spain.
authors: Kristy
authors: K
authors: Vogels
authors: LIPPSO, Department of Chemistry, University of Girona , Maria Aurèlia Capmany 69, 17003 Girona, Spain.
authors: Marta
authors: M
authors: Planas
authors: LIPPSO, Department of Chemistry, University of Girona , Maria Aurèlia Capmany 69, 17003 Girona, Spain.
authors: Lidia
authors: L
authors: Feliu