title: Association of rs10811656 on 9P21.3 with the risk of coronary artery disease in a Chinese population.
abstract: BACKGROUND
  Genome-wide association studies have reported that the 9p21.3 locus confers risk for coronary artery disease (CAD). However, it is not known whether rs10811656 is linked with CAD in a Chinese population. Thus, the purpose of this study was to investigate the potential association between rs10811656 and the risk of CAD in a Chinese population.
  
  
  METHODS
  We conducted a hospital-based, case-control study with 251 CAD patients and 304 controls to examine the potential association of rs10811656 with CAD.
  
  
  RESULTS
  The frequencies of the TT genotypes in CAD cases were significantly different from those in controls (adjusted OR: 1.96, 95 % CI: 1.09-3.505, P = 0.024). Compared to controls, rs10811656 was significantly associated with the stable angina pectoris (adjusted OR: 1.42, 95 % CI: 1.06-1.90, P = 0.017), but not with acute coronary syndrome. There was also a highly significant association of rs10811656 with double-vessel and triple-vessel disease when patients were divided into subgroups based on the number of diseased vessels (adjusted OR: 1.68 and 1.60, 95 % CI: 1.14-2.44 and 1.10-2.33, P = 0.009 and 0.02, respectively).
  
  
  CONCLUSIONS
  Our results suggest that the rs10811656 locus might be associated with CAD in a Chinese Han population.
authors: Department of Cardiology, the First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China.|Devision of Cardiology, The Affiliated Jiangning Hospital of Nanjing Medical University, Nanjing, 211100, China.
authors: Jianjun
authors: J
authors: Yan
authors: Department of Cardiology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, East Campus, No. 222, Huanhu Xisan Road, Pudong New Area, Shanghai, 201306, China.
authors: Jinmei
authors: J
authors: Zeng
authors: Department of Cardiology, the First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China.
authors: Zhiyong
authors: Z
authors: Xie
authors: Department of Cardiology, the First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China.
authors: Dongchen
authors: D
authors: Liu
authors: Department of Cardiology, the First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China. drlswang@njmu.edu.cn.
authors: Liansheng
authors: L
authors: Wang
authors: Department of Cardiology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, East Campus, No. 222, Huanhu Xisan Road, Pudong New Area, Shanghai, 201306, China. zhongchen7498@sina.com.cn.
authors: Zhong
authors: Z
authors: Chen
mesh_terms: D000368:Aged; D044466:Asian People / Q000235:genetics; D016022:Case-Control Studies; D002681:China; D003324:Coronary Artery Disease / Q000235:genetics* / Q000473:pathology; D050762:Cyclin-Dependent Kinase Inhibitor p15 / Q000235:genetics*; D019941:Cyclin-Dependent Kinase Inhibitor p16; D050763:Cyclin-Dependent Kinase Inhibitor p18 / Q000235:genetics*; D005260:Female; D019942:Genes, p16; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D055106:Genome-Wide Association Study; D005838:Genotype; D006801:Humans; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D012307:Risk Factors; D012737:Sex Factors; D012907:Smoking
chemical_list: C000614131:CDKN2A protein, human; C493966:CDKN2B protein, human; D050762:Cyclin-Dependent Kinase Inhibitor p15; D019941:Cyclin-Dependent Kinase Inhibitor p16; D050763:Cyclin-Dependent Kinase Inhibitor p18; D008055:Lipids
keywords: Association; CAD, coronary artery disease; SNP, single nucleotide polymorphism; Susceptibility; rs10811656