title: Structural regulation of self-assembled iron oxide/polymer microbubbles towards performance-tunable magnetic resonance/ultrasonic dual imaging agents.
abstract: Fe3O4/polymer hybrid microcapsules were prepared via a template-free route which is based on polyamine-salt aggregates (PSAs) self-assembly approach. The measurements of transmission electron microscopy (TEM) indicated that the diameter and shell thickness of the microcapsules could be tuned by varying the experimental conditions, such as the concentration of reactants and evolution time employed during the PSA assembly. The results of vibrating sample magnetometer (VSM) demonstrated that the magnetic nanoparticles content of the synthesized microcapsules was tunable and all samples exhibited superparamagnetic behavior. After filling appropriate perfluorocarbon into the inner cavities of the microcapsules, the biomedical applications of the resultant microbubbles, including ultrasonic imaging (USI) and magnetic resonance imaging (MRI), were studied in vitro. It showed that the synthesized magnetic microbubbles possessed both strong ultrasound contrast enhancement capability and high relaxation rate. The excellent acoustic and magnetic properties of these self-assembled microbubbles ensure that the Fe3O4/polymer hybrid microbubbles have great potential as MRI/USI dual-modality contrast agents.
authors: The State Key Laboratory of Metal Matrix Composites, School of Materials Science and Engineering, Shanghai Jiao Tong University, Shanghai 200240, PR China.
authors: Heze
authors: H
authors: Guo
authors: The State Key Laboratory of Metal Matrix Composites, School of Materials Science and Engineering, Shanghai Jiao Tong University, Shanghai 200240, PR China.
authors: Zequan
authors: Z
authors: Jiang
authors: The State Key Laboratory of Metal Matrix Composites, School of Materials Science and Engineering, Shanghai Jiao Tong University, Shanghai 200240, PR China.
authors: Sheng
authors: S
authors: Song
authors: Department of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Tissue Engineering National Tissue Engineering Centre of China, Shanghai 200011, PR China.
authors: Tingting
authors: T
authors: Dai
authors: The State Key Laboratory of Metal Matrix Composites, School of Materials Science and Engineering, Shanghai Jiao Tong University, Shanghai 200240, PR China.
authors: Xiyang
authors: X
authors: Wang
authors: The State Key Laboratory of Metal Matrix Composites, School of Materials Science and Engineering, Shanghai Jiao Tong University, Shanghai 200240, PR China.
authors: Kang
authors: K
authors: Sun
authors: Department of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Tissue Engineering National Tissue Engineering Centre of China, Shanghai 200011, PR China.
authors: Guangdong
authors: G
authors: Zhou
authors: The State Key Laboratory of Metal Matrix Composites, School of Materials Science and Engineering, Shanghai Jiao Tong University, Shanghai 200240, PR China; School of Chemistry, University of Bristol, Cantock's Close, Bristol BS8 1TS, United Kingdom. Electronic address: hjdou@sjtu.edu.cn.
authors: Hongjing
authors: H
authors: Dou
mesh_terms: D000162:Acoustics; D002214:Capsules / Q000737:chemistry; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D003287:Contrast Media / Q000737:chemistry* / Q000494:pharmacology; D042783:Endothelial Cells / Q000166:cytology / Q000187:drug effects; D052203:Ferrosoferric Oxide / Q000737:chemistry* / Q000494:pharmacology; D005347:Fibroblasts / Q000166:cytology / Q000187:drug effects; D005466:Fluorocarbons / Q000737:chemistry; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D058185:Magnetite Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D045423:Microbubbles; D011073:Polyamines / Q000737:chemistry; D014463:Ultrasonography / Q000379:methods*
chemical_list: D002214:Capsules; D003287:Contrast Media; D005466:Fluorocarbons; D058185:Magnetite Nanoparticles; D011073:Polyamines; D052203:Ferrosoferric Oxide
keywords: Hybrid microbubble; MRI/ultrasonic dual-modality contrast agent; Magnetic nanoparticle; Self-assembly