title: Dynamics and Molecular Mechanisms of Ventricular Fibrillation in Structurally Normal Hearts.
abstract: Ventricular fibrillation (VF) is the most severe cardiac rhythm disturbance and one of the most important immediate causes of sudden cardiac death. In the structurally normal heart, a small number of stable reentrant sources, perhaps 1 or 2, underlie the mechanism of VF, and the stabilization of the sources, their frequency, and the complexity of the turbulent waves they generate depend on the expression, spatial distribution, and intermolecular interactions of the 2 most important ion channels that control cardiac excitability: the inward rectifier potassium channel, Kir2.1, and the alpha subunit of the main cardiac sodium channel, NaV1.5.
authors: Center for Arrhythmia Research, North Campus Research Complex, University of Michigan, 2800 Plymouth Road, Ann Arbor, MI 48109, USA. Electronic address: jjalife@umich.edu.
authors: José
authors: J
authors: Jalife
mesh_terms: D006321:Heart / Q000502:physiology*; D006329:Heart Conduction System / Q000503:physiopathology*; D006801:Humans; D007473:Ion Channels / Q000502:physiology*; D014693:Ventricular Fibrillation / Q000503:physiopathology*
chemical_list: D007473:Ion Channels
keywords: Dominant frequency; Fibrillatory conduction ionic mechanisms; Na(V)1.5-Kir2.1 interactions; Rotors