title: Solanum tuberosum L. cv Hongyoung extract inhibits 2,4‑dinitrochlorobenzene‑induced atopic dermatitis in NC/Nga mice.
abstract: Solanum tuberosum L. cv Hongyoung (SH) is a widely consumed anthocyanin-rich food and medicinal plant, which possesses anti‑inflammatory and anti‑allergic activities. The present study aimed to examine the inhibitory effects of SH extract on atopic dermatitis (AD)‑like skin lesions induced by the topical application of 2,4‑dinitrochlorobenzene (DNCB) in NC/Nga mice. SH extract was orally administered to the DNCB‑treated NC/Nga mice. The anti‑AD effects of SH extract were examined by measuring symptom severity; ear thickness; scratching behavior; serum levels of immunoglobulin (Ig)E; T‑helper (Th)1, Th2 and Th17 cytokine levels in the spleen; mRNA expression levels of inflammatory cytokines and chemokines; and tissue infiltration of inflammatory cells. The results demonstrated that SH extract inhibited the development of AD‑like lesions, and reduced IgE levels and the production of cytokines. Furthermore, SH extract significantly suppressed the expression of AD‑associated mRNAs in lesional skin. Histological alterations in the AD‑like lesions were visualized using hematoxylin and eosin, and toluidine blue staining in the DNCB‑treated group; the alterations were attenuated following SH treatment. In addition, thickening of the epidermis and accumulation of inflammatory cells in the DNCB‑treated mice were suppressed by SH treatment. These results suggested that SH extract may suppress the development of AD symptoms through modulation of the Th1 and Th2 responses.
authors: Department of Life and Nanopharmaceutical Science of Pharmacy, College of Pharmacy, Kyung Hee University, Seoul 130‑701, Republic of Korea.
authors: Myung Ah
authors: MA
authors: Kang
authors: Department of Life and Nanopharmaceutical Science of Pharmacy, College of Pharmacy, Kyung Hee University, Seoul 130‑701, Republic of Korea.
authors: Se-Young
authors: SY
authors: Choung
mesh_terms: D000818:Animals; D000872:Anthocyanins / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*; D016207:Cytokines / Q000032:analysis / Q000235:genetics; D003876:Dermatitis, Atopic / Q000097:blood / Q000139:chemically induced / Q000188:drug therapy* / Q000473:pathology; D004137:Dinitrochlorobenzene; D005786:Gene Expression Regulation / Q000187:drug effects; D007074:Immunoglobulin G / Q000097:blood; D008297:Male; D051379:Mice; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*; D012333:RNA, Messenger / Q000235:genetics; D012867:Skin / Q000187:drug effects* / Q000473:pathology; D011198:Solanum tuberosum / Q000737:chemistry*
chemical_list: D000872:Anthocyanins; D016207:Cytokines; D004137:Dinitrochlorobenzene; D007074:Immunoglobulin G; D010936:Plant Extracts; D012333:RNA, Messenger