title: Striatal silent lacunar infarction is associated with changes to the substantia nigra in patients with early-stage Parkinson's disease: A diffusion kurtosis imaging study.
abstract: A recent study has shown that striatal silent infarction may occur secondary to the degeneration of dopaminergic neurons in the substantia nigra (SN) of mice. However, it is uncertain whether this phenomenon occurs in patients with early-stage Parkinson's disease (PD) and can be detected by diffusion kurtosis imaging (DKI). A total of 72 untreated patients with early-stage PD underwent conventional MRI and DKI. Participants were divided into control and striatal silent lacunar infarction (SSLI) groups. The differences in mean kurtosis (MK) values of the SN, Hoehn-Yahr (H-Y) staging, and Unified Parkinson's Disease Rating Scale (UPDRS) III score between groups, were analyzed. Linear regression analysis was used to correlate age, SSLI count, silent lacunar infarction count in other brain areas and age-related white matter change score with MK values of the SN. Spearman correlation coefficient analysis was used to correlate MK values of the SN and SSLI count with H-Y staging and UPDRS III score. There was no significant difference in the severity of disease between two groups; however, MK values of the SN with SSLI present were significantly higher than in SN without SSLI. In addition, SSLI count had linear correlation with MK values of the SN, which had positive correlation with H-Y-staging and UPDRS III score. SSLI is associated with structural changes to the SN in patients with early-stage PD, detectable by DKI, and may aggravate their motor impairments.
authors: Department of Neurology, Guangdong Neuroscience Institute, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510080, Guangdong, People's Republic of China; Dapartment of Neurology, The First People's Hospital of Foshan, Foshan, Guangdong, People's Republic of China.
authors: Guohua
authors: G
authors: Zhang
authors: Department of Neurology, Guangdong Neuroscience Institute, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510080, Guangdong, People's Republic of China.
authors: Yuhu
authors: Y
authors: Zhang
authors: Dapartment of Neurology, The First People's Hospital of Foshan, Foshan, Guangdong, People's Republic of China.
authors: Chengguo
authors: C
authors: Zhang
authors: Dapartment of Neurology, The First People's Hospital of Foshan, Foshan, Guangdong, People's Republic of China.
authors: Yukai
authors: Y
authors: Wang
authors: Department of Neurology, Guangdong Neuroscience Institute, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510080, Guangdong, People's Republic of China.
authors: Guixian
authors: G
authors: Ma
authors: Department of Neurology, Guangdong Neuroscience Institute, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510080, Guangdong, People's Republic of China.
authors: Kun
authors: K
authors: Nie
authors: Dapartment of Neurology, The First People's Hospital of Foshan, Foshan, Guangdong, People's Republic of China.
authors: Haiqun
authors: H
authors: Xie
authors: Dapartment of Neurology, The First People's Hospital of Foshan, Foshan, Guangdong, People's Republic of China.
authors: Jianping
authors: J
authors: Liu
authors: Department of Neurology, Guangdong Neuroscience Institute, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510080, Guangdong, People's Republic of China. Electronic address: wljgd68@163.com.
authors: Lijuan
authors: L
authors: Wang
mesh_terms: D000368:Aged; D003342:Corpus Striatum / Q000000981:diagnostic imaging*; D003430:Cross-Sectional Studies; D056324:Diffusion Tensor Imaging / Q000379:methods; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000150:complications / Q000000981:diagnostic imaging*; D059409:Stroke, Lacunar / Q000150:complications / Q000000981:diagnostic imaging*; D013378:Substantia Nigra / Q000000981:diagnostic imaging*
keywords: Diffusion kurtosis imaging; Mean kurtosis; Parkinson’s disease; Striatal silent lacunar infarction; Structural changes; Substantia nigra