title: Circulating tumor cell is a common property of brain glioma and promotes the monitoring system.
abstract: Brain glioma is the most common primary intracranial tumor characterized by dismal prognosis and frequent recurrence, yet a real-time and reliable biological approach to monitor tumor response and progression is still lacking. Recently, few studies have reported that circulating tumor cells (CTCs) could be detected in glioblastoma multiform (GBM), providing the possibility of its application in brain glioma monitoring system. But its application limits still exist, because the detection rate of CTCs is still low and was exclusively limited to high- grade gliomas. Here, we adopted an advanced integrated cellular and molecular approach of SE-iFISH to detect CTCs in the peripheral blood (PB) of patients with 7 different subtypes of brain glioma, uncovering the direct evidences of glioma migration. We identified CTCs in the PB from 24 of 31 (77%) patients with glioma in all 7 subtypes. No statistical difference of CTC incidence and count was observed in different pathological subtypes or WHO grades of glioma. Clinical data revealed that CTCs, to some extent, was superior to MRI in monitoring the treatment response and differentiating radionecrosis from recurrence of glioma. Conclusively, CTCs is a common property of brain gliomas of various pathological subtypes, which has provided an ultimate paradox for the hypothesis "soil and seed". It can be used to monitor the microenvironment of gliomas dynamically, which will be a meaningful complement to radiographic imaging.
authors: Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.|China National Clinical Research Center for Neurological Diseases, Beijing, China.|Institute for Brain Disorders and Beijing Key Laboratory of Brian Tumor, Beijing, China.
authors: Faliang
authors: F
authors: Gao
authors: Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.|China National Clinical Research Center for Neurological Diseases, Beijing, China.|Institute for Brain Disorders and Beijing Key Laboratory of Brian Tumor, Beijing, China.
authors: Yong
authors: Y
authors: Cui
authors: Department of Neurosurgery, First Hospital of Tsinghua University, Beijing, China.
authors: Haihui
authors: H
authors: Jiang
authors: Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.|China National Clinical Research Center for Neurological Diseases, Beijing, China.|Institute for Brain Disorders and Beijing Key Laboratory of Brian Tumor, Beijing, China.
authors: Dali
authors: D
authors: Sui
authors: Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.|China National Clinical Research Center for Neurological Diseases, Beijing, China.|Institute for Brain Disorders and Beijing Key Laboratory of Brian Tumor, Beijing, China.
authors: Yonggang
authors: Y
authors: Wang
authors: Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.|China National Clinical Research Center for Neurological Diseases, Beijing, China.|Institute for Brain Disorders and Beijing Key Laboratory of Brian Tumor, Beijing, China.
authors: Zhongli
authors: Z
authors: Jiang
authors: Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.|China National Clinical Research Center for Neurological Diseases, Beijing, China.|Institute for Brain Disorders and Beijing Key Laboratory of Brian Tumor, Beijing, China.
authors: Jizong
authors: J
authors: Zhao
authors: Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.|China National Clinical Research Center for Neurological Diseases, Beijing, China.|Institute for Brain Disorders and Beijing Key Laboratory of Brian Tumor, Beijing, China.
authors: Song
authors: S
authors: Lin
mesh_terms: D000328:Adult; D000368:Aged; D001932:Brain Neoplasms / Q000235:genetics / Q000473:pathology*; D002898:Chromosomes, Human, Pair 8; D005260:Female; D005910:Glioma / Q000235:genetics / Q000473:pathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D009360:Neoplastic Cells, Circulating; D011123:Polyploidy
keywords: biomarker; circulating tumor cell (CTC); glioma; monitor; radionecrosis