title: TAS2R38 taste receptor gene and chronic rhinosinusitis: new data from an Italian population.
abstract: Chronic rhinosinusitis (CRS) is a frequent disease with high social impact and multifactorial pathogenesis. Recently, single nucleotide polymorphisms within the TAS2R38 gene have been implicated as possible contributors to the complex gene-environment interactions in CRS. The purpose of this study was to confirm the proposed correlation between TAS2R38 genotype, CRS and related comorbidities.
  
  
  
  Fifty-three CRS patients and 39 healthy individuals were genotyped at the TAS2R38 locus. CRS patients were treated by endoscopic sinus surgery and medical therapies and subdivided in CRS with nasal polyps (CRSwNPs) and CRS without nasal polyps (CRSsNPs). The effect of genotype on CRS and CRS-related comorbidities was assessed.
  
  
  
  The distribution of the different genotypes at the TAS2R38 locus was not significantly different between CRS patients, either with or without nasal polyps, and controls. Besides, no association was found between the different genotypes at the TAS2R38 locus and CRS-related comorbidities.
  
  
  
  No association was found between TAS2R38 alleles or genotypes and CRS, thus questioning its role in the pathogenesis of CRS.
authors: Clinica Otorinolaringoiatrica, Ospedale di Circolo e Fondazione Macchi, Università degli Studi dell'Insubria, Varese, Italy.|Dipartimento di Biotecnologie e Scienze della Vita (DBSV), Università dell'Insubria, Via J.H. Dunant, 3, Varese, 21100, Italy.
authors: Stefania
authors: S
authors: Gallo
authors: Dipartimento di Biotecnologie e Scienze della Vita (DBSV), Università dell'Insubria, Via J.H. Dunant, 3, Varese, 21100, Italy.
authors: Sarah
authors: S
authors: Grossi
authors: Clinica Otorinolaringoiatrica, Ospedale di Circolo e Fondazione Macchi, Università degli Studi dell'Insubria, Varese, Italy.
authors: Giulia
authors: G
authors: Montrasio
authors: Dipartimento di Biotecnologie e Scienze della Vita (DBSV), Università dell'Insubria, Via J.H. Dunant, 3, Varese, 21100, Italy.
authors: Giorgio
authors: G
authors: Binelli
authors: Dipartimento di Biotecnologie e Scienze della Vita (DBSV), Università dell'Insubria, Via J.H. Dunant, 3, Varese, 21100, Italy.
authors: Raffaella
authors: R
authors: Cinquetti
authors: Center for Rhinology, Skull Base Surgery and Facial Plastic Surgery, ORL-Zentrum, Klinik Hirslanden, Zurich, Switzerland.
authors: Daniel
authors: D
authors: Simmen
authors: Clinica Otorinolaringoiatrica, Ospedale di Circolo e Fondazione Macchi, Università degli Studi dell'Insubria, Varese, Italy.|Dipartimento di Biotecnologie e Scienze della Vita (DBSV), Università dell'Insubria, Via J.H. Dunant, 3, Varese, 21100, Italy.
authors: Paolo
authors: P
authors: Castelnuovo
authors: Dipartimento di Biotecnologie e Scienze della Vita (DBSV), Università dell'Insubria, Via J.H. Dunant, 3, Varese, 21100, Italy. paola.campomenosi@uninsubria.it.|The Protein Factory, Centro Interuniversitario di Ricerca in Biotecnologie Proteiche, Politecnico di Milano, ICRM-CNR Milano and Università degli Studi dell'Insubria, Varese, Italy. paola.campomenosi@uninsubria.it.
authors: Paola
authors: 0000-0002-8853-1134
authors: P
authors: Campomenosi
mesh_terms: D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D005260:Female; D059647:Gene-Environment Interaction; D020022:Genetic Predisposition to Disease; D006801:Humans; D007558:Italy; D008297:Male; D008875:Middle Aged; D009298:Nasal Polyps / Q000473:pathology* / Q000601:surgery; D057605:Natural Orifice Endoscopic Surgery / Q000379:methods; D020641:Polymorphism, Single Nucleotide; D011446:Prospective Studies; D043562:Receptors, G-Protein-Coupled / Q000235:genetics*; D012220:Rhinitis / Q000235:genetics / Q000628:therapy*; D012852:Sinusitis / Q000235:genetics / Q000628:therapy*; D044465:White People / Q000235:genetics; D000098706:Taste Receptors, Type 2
chemical_list: D043562:Receptors, G-Protein-Coupled; D000098706:Taste Receptors, Type 2
keywords: Bitter taste receptor T2R38; Chronic rhinosinusitis; Genotyping; Pathogenesis; TAS2R38 gene