title: Respiratory Muscle Assessment in Acute Guillain-Barré Syndrome.
abstract: Guillain-Barré Syndrome (GBS) is a life-threatening disease due to respiratory muscle involvement. This study aimed at objectively assessing the course of respiratory muscle function in GBS subjects within the first week of admission to an intensive care unit.
  
  
  
  Medical Research Council Sum Score (MRC-SS), vigorimetry, spirometry, and respiratory muscle function tests (inspiratory/expiratory muscle strength: PImax/PEmax, sniff nasal pressure: SnPna) were assessed twice daily. GBS Disability Score (GBS-DS) was assessed once daily. On days one (d1) and seven (d7), blood gases and twitch mouth pressure during magnetic phrenic nerve stimulation (Pmo,tw) were additionally evaluated.
  
  
  
  Nine subjects were included. MRC-SS, vigorimetry, PImax, and SnPna increased between d1 and d7. GBS-DS, spirometry and Pmo,tw remained unaltered. Only SnPna correlated closely with the MRC-SS on both d1 (r = 0.77, p = 0.02) and d7 (r = 0.74, p = 0.02).
  
  
  
  SnPna was the only parameter that correlated with MRC-SS, while the current gold standard of spirometry measurement did not.
authors: Clinic for Pneumology, Department of Internal Medicine, University Hospital Freiburg, Freiburg, Germany. stephan.walterspacher@glkn.de.|Department of Pneumology, Kliniken der Stadt Köln gGmbH Cologne, University of Witten/Herdecke, Witten, Germany. stephan.walterspacher@glkn.de.|Department of Pneumology, Cardiology, Intensive Care Medicine, Academic Teaching Hospital University Freiburg, Klinikum Konstanz, Luisenstrasse 7, 78464, Constance, Germany. stephan.walterspacher@glkn.de.
authors: S
authors: 0000-0003-3061-1251
authors: S
authors: Walterspacher
authors: Clinic for Pneumology, Department of Internal Medicine, University Hospital Freiburg, Freiburg, Germany.
authors: A
authors: A
authors: Kirchberger
authors: Department of Neurology, University Hospital Freiburg, Freiburg, Germany.
authors: J
authors: J
authors: Lambeck
authors: Clinic for Pneumology, Department of Internal Medicine, University Hospital Freiburg, Freiburg, Germany.|Department of Pneumology, Kliniken der Stadt Köln gGmbH Cologne, University of Witten/Herdecke, Witten, Germany.|Department of Pneumology, Cardiology, Intensive Care Medicine, Academic Teaching Hospital University Freiburg, Klinikum Konstanz, Luisenstrasse 7, 78464, Constance, Germany.
authors: D J
authors: DJ
authors: Walker
authors: Clinic for Pneumology, Department of Internal Medicine, University Hospital Freiburg, Freiburg, Germany.
authors: A
authors: A
authors: Schwörer
authors: Department of Neurology, University Hospital Freiburg, Freiburg, Germany.
authors: W D
authors: WD
authors: Niesen
authors: Clinic for Pneumology, Department of Internal Medicine, University Hospital Freiburg, Freiburg, Germany.|Department of Pneumology, Kliniken der Stadt Köln gGmbH Cologne, University of Witten/Herdecke, Witten, Germany.
authors: W
authors: W
authors: Windisch
authors: Department of Neurology, University Hospital Freiburg, Freiburg, Germany.|Section of Neurological Rehabilitation, Hans Berger Department of Neurology, Jena University Hospital, Jena, Germany.
authors: F
authors: F
authors: Hamzei
authors: Clinic for Pneumology, Department of Internal Medicine, University Hospital Freiburg, Freiburg, Germany.|Department of Pneumology, Cardiology, Intensive Care Medicine, Academic Teaching Hospital University Freiburg, Klinikum Konstanz, Luisenstrasse 7, 78464, Constance, Germany.
authors: H J
authors: HJ
authors: Kabitz
mesh_terms: D000208:Acute Disease; D000368:Aged; D004185:Disability Evaluation; D045853:Exhalation; D005260:Female; D020275:Guillain-Barre Syndrome / Q000503:physiopathology*; D006801:Humans; D001239:Inhalation; D008297:Male; D008875:Middle Aged; D053580:Muscle Strength; D012132:Respiratory Muscles / Q000503:physiopathology*; D012720:Severity of Illness Index; D013147:Spirometry
keywords: Acute Inflammatory Demyelinating Polyneuropathy (AIDP); Diaphragm; Guillain–Barré Syndrome; Intensive care; Respiratory muscle strength; Sniff nasal pressure; Vital capacity