title: [Not Available].
abstract: BACKGROUND
  The different body components may contribute to the development of insulin resistance and type 2 diabetes mellitus. The aim of the present study was to examine the association of fat mass and fat free mass indices with markers of insulin resistance, independently of each other and giving, at the same time, gender-specific information in a wide cohort of European adolescents.
  
  
  METHODS
  A cross-sectional study in a school setting was conducted in 925 (430 males) adolescents (14.9 ± 1.2 years). Weight, height, anthropometric, bioimpedance and blood parameters were measured. Indices for fat mass and fat free mass, and homeostatic model assessment (HOMA) were calculated. Multiple regression analyses were performed adjusting for several confounders including fat free mass and fat mass when possible.
  
  
  RESULTS
  Indices of fat mass were positively associated with HOMA (all p < 0.01) after adjusting for all the confounders including fat free mass indices, in both sexes. Fat free mass indices were associated with HOMA, in both males and females, after adjusting for center, pubertal status, socioeconomic status and cardiorespiratory fitness, but the associations disappear when including fat mass indices in the adjustment´s model.
  
  
  CONCLUSIONS
  Fat mass indices derived from different methods are positively associated with insulin resistance independently of several confounders including fat free mass indices. In addition, the relationship of fat free mass with insulin resistance is influenced by the amount of fat mass in European adolescents. Nevertheless, future studies should focus not only on the role of fat mass, but also on other body components such as fat free mass because its role could vary depending of the level and distribution of fat mass.
authors: GENUD Research Group. david.jimenez@uca.es.
authors: María
authors: M
authors: Sese
authors: Luis A
authors: LA
authors: Moreno
authors: Laura
authors: L
authors: Censi
authors: Cristina
authors: C
authors: Bresidenassel
authors: Marcela
authors: M
authors: González-Gross
authors: Michael
authors: M
authors: Sjöström
authors: Yannis
authors: Y
authors: Manios
authors: Molnár
authors: M
authors: Dénes
authors: Jean
authors: J
authors: Dallongeville
authors: Kurt
authors: K
authors: Widhalm
authors: Frederic
authors: F
authors: Gottrand
authors: Steffan
authors: S
authors: De-Henauw
authors: Ascensión
authors: A
authors: Marcos
authors: Manuel
authors: M
authors: CastilloGarzón
authors: David
authors: D
authors: Jiménez-Pavón
mesh_terms: D050154:Adiposity / Q000502:physiology; D000293:Adolescent; D000886:Anthropometry; D001823:Body Composition / Q000502:physiology*; D002648:Child; D003430:Cross-Sectional Studies; D005060:Europe / Q000453:epidemiology; D005260:Female; D006801:Humans; D007333:Insulin Resistance / Q000502:physiology*; D008297:Male; D009765:Obesity / Q000453:epidemiology / Q000503:physiopathology
keywords: Insulin resistance. Adolescent. Body fat. Obesity.