title: Lactam inhibiting Streptococcus mutans growth on titanium.
abstract: The aim of this work was to analyze the activity of novel synthetic lactams on preventing biofilm formation on titanium surfaces. Titanium (Ti6Al4V) samples were exposed to Streptococcus mutans cultures in the presence or absence of a synthetic lactam. After 48h incubation, planktonic growth was determined by spectrophotometry. Biofilm was evaluated by crystal violet staining and colony forming units (CFU·ml(-)(1)), followed by scanning electron microscopy (SEM). Results showed that the average of adhered viable cells was approximately 1.5×10(2)CFU/ml in the presence of lactam and 4×10(2)CFU/ml in its absence. This novel compound was considerable active in reducing biofilm formation over titanium surfaces, indicating its potential for the development of antimicrobial drugs targeting the inhibition of the initial stages of bacterial biofilms on dental implants abutments.
authors: Center for Research on Dental Implants (CEPID), School of Dentistry (ODT), Federal University of Santa Catarina (UFSC), Florianópolis/SC, 88040-900, Brazil.
authors: J G
authors: JG
authors: Xavier
authors: Center for Research on Dental Implants (CEPID), School of Dentistry (ODT), Federal University of Santa Catarina (UFSC), Florianópolis/SC, 88040-900, Brazil.
authors: T C
authors: TC
authors: Geremias
authors: Center for Research on Dental Implants (CEPID), School of Dentistry (ODT), Federal University of Santa Catarina (UFSC), Florianópolis/SC, 88040-900, Brazil.
authors: J F D
authors: JFD
authors: Montero
authors: Herman Ostrow School of Dentistry of USC, 925 W 34 St, Los Angeles, CA 90089, United States.
authors: B R
authors: BR
authors: Vahey
authors: Center for Research on Dental Implants (CEPID), School of Dentistry (ODT), Federal University of Santa Catarina (UFSC), Florianópolis/SC, 88040-900, Brazil.
authors: C A M
authors: CAM
authors: Benfatti
authors: Center for Research on Dental Implants (CEPID), School of Dentistry (ODT), Federal University of Santa Catarina (UFSC), Florianópolis/SC, 88040-900, Brazil.
authors: J C M
authors: JCM
authors: Souza
authors: Center for Research on Dental Implants (CEPID), School of Dentistry (ODT), Federal University of Santa Catarina (UFSC), Florianópolis/SC, 88040-900, Brazil.
authors: R S
authors: RS
authors: Magini
authors: Department of Biologia, ERRMECe, Université de Cergy Pontoise, 2, Av. Adolphe Chauvin 95302 Cergy, Pontoise, France; Integrated Laboratories Technologies (InteLab), Dept. Chemical and Food Engineering (EQA), Federal University of Santa Catarina (UFSC), Florianópolis/SC, 88040-970, Brazil. Electronic address: andrea@intelab.ufsc.br.
authors: A L
authors: AL
authors: Pimenta
mesh_terms: D000497:Alloys; D018441:Biofilms / Q000187:drug effects* / Q000254:growth & development*; D007769:Lactams / Q000737:chemistry / Q000494:pharmacology; D064347:Microscopy, Electrochemical, Scanning; D013295:Streptococcus mutans / Q000502:physiology* / Q000648:ultrastructure; D014025:Titanium / Q000737:chemistry*
chemical_list: D000497:Alloys; D007769:Lactams; C031462:titanium alloy (TiAl6V4); D014025:Titanium
keywords: Antibiofilm activity; Bacterial adhesion; Biofilms; Lactams; Modified Calgary device; Streptococcus mutans