title: Molecular Pathology: Predictive, Prognostic, and Diagnostic Markers in Salivary Gland Tumors.
abstract: Although initial attempts at using ancillary studies in salivary gland tumor classification were viewed with skepticism, numerous advances over the past decade have established a role for assessment of molecular alterations in the diagnosis and potential prognosis and treatment of salivary gland tumors. Many monomorphic salivary tumors are now known to harbor defining molecular alterations, usually translocations. Pleomorphic, high-grade carcinomas tend to have complex alterations that are often further limited by inaccuracy of initial classification by morphologic and immunophenotypic features. Next-generation sequencing techniques have great potential in many aspects of salivary gland tumor classification and biomarker discovery.
authors: Department of Pathology and Laboratory Medicine, Presbyterian University Hospital, University of Pittsburgh, 200 Lothrop Street, Pittsburgh, PA 15213, USA. Electronic address: seethalarr@upmc.edu.
authors: Raja R
authors: RR
authors: Seethala
authors: Department of Pathology and Laboratory Medicine, Emory University Hospital, Midtown 550 Peachtree Street, Atlanta, GA 30308, USA.
authors: Christopher C
authors: CC
authors: Griffith
mesh_terms: D000230:Adenocarcinoma / Q000175:diagnosis / Q000235:genetics / Q000473:pathology; D014408:Biomarkers, Tumor / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000235:genetics; D006801:Humans; D025202:Molecular Diagnostic Techniques / Q000379:methods*; D057089:Pathology, Molecular; D010641:Phenotype; D011237:Predictive Value of Tests; D015203:Reproducibility of Results; D012468:Salivary Gland Neoplasms / Q000175:diagnosis* / Q000235:genetics / Q000473:pathology*; D012469:Salivary Glands / Q000473:pathology*; D014178:Translocation, Genetic
chemical_list: D014408:Biomarkers, Tumor
keywords: Classification; Molecular; Mutations; Salivary; Translocations