title: Oxidative Damage Induced by Arsenic in Mice or Rats: A Systematic Review and Meta-Analysis.
abstract: In this meta-analysis, studies reporting arsenic-induced oxidative damage in mouse models were systematically evaluated to provide a scientific understanding of oxidative stress mechanisms associated with arsenic poisoning. Fifty-eight relevant peer-reviewed publications were identified through exhaustive database searching. Oxidative stress indexes assessed included superoxide dismutase (SOD), catalase (CAT), glutathione (GSH), glutathione peroxidase (GPx), glutathione-s-transferase (GST), glutathione reductase (GR), oxidized glutathione (GSSG), malondialdehyde (MDA), and reactive oxygen species (ROS). Our meta-analysis showed that arsenic exposure generally suppressed measured levels of the antioxidants, SOD, CAT, GSH, GPx, GST, and GR, but increased levels of the oxidants, GSSG, MDA, and ROS. Arsenic valence was important and GR and MDA levels increased to a significantly (P < 0.05) greater extent upon exposure to As3+than to As5+. Other factors that contributed to a greater overall oxidative effect from arsenic exposure included intervention time, intervention method, dosage, age of animals, and the sample source from which the indexes were estimated. Our meta-analysis effectively summarized a wide range of studies and detected a positive relationship between arsenic exposure and oxidative damage. These data provide a scientific basis for the prevention and treatment of arsenic poisoning.
authors: School of Medicine, Shihezi University, Shihezi, Xinjiang, 832000, China.
authors: Mengchuan
authors: http://orcid.org/0000-0001-6162-7438
authors: M
authors: Xu
authors: School of Medicine, Shihezi University, Shihezi, Xinjiang, 832000, China.
authors: Dongsheng
authors: D
authors: Rui
authors: School of Medicine, Shihezi University, Shihezi, Xinjiang, 832000, China.
authors: Yizhong
authors: Y
authors: Yan
authors: School of Medicine, Shihezi University, Shihezi, Xinjiang, 832000, China.
authors: Shangzhi
authors: S
authors: Xu
authors: School of Medicine, Shihezi University, Shihezi, Xinjiang, 832000, China.
authors: Qiang
authors: Q
authors: Niu
authors: School of Medicine, Shihezi University, Shihezi, Xinjiang, 832000, China.
authors: Gangling
authors: G
authors: Feng
authors: School of Medicine, Shihezi University, Shihezi, Xinjiang, 832000, China.
authors: Yan
authors: Y
authors: Wang
authors: School of Medicine, Shihezi University, Shihezi, Xinjiang, 832000, China. lishugang@ymail.com.
authors: Shugang
authors: S
authors: Li
authors: School of Medicine, Shihezi University, Shihezi, Xinjiang, 832000, China. shzujmx@sina.com.
authors: Mingxia
authors: M
authors: Jing
mesh_terms: D000367:Age Factors; D000818:Animals; D000975:Antioxidants / Q000378:metabolism; D001151:Arsenic / Q000633:toxicity*; D020261:Arsenic Poisoning / Q000378:metabolism*; D002374:Catalase / Q000378:metabolism; D005978:Glutathione / Q000378:metabolism; D019803:Glutathione Disulfide / Q000378:metabolism; D005979:Glutathione Peroxidase / Q000378:metabolism; D005980:Glutathione Reductase / Q000378:metabolism; D005982:Glutathione Transferase / Q000378:metabolism; D008315:Malondialdehyde / Q000378:metabolism; D051379:Mice; D010084:Oxidation-Reduction / Q000187:drug effects; D018384:Oxidative Stress / Q000187:drug effects*; D051381:Rats; D017382:Reactive Oxygen Species / Q000378:metabolism; D012044:Regression Analysis; D013482:Superoxide Dismutase / Q000378:metabolism; D013997:Time Factors
chemical_list: D000975:Antioxidants; D017382:Reactive Oxygen Species; D008315:Malondialdehyde; D002374:Catalase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D005980:Glutathione Reductase; D005982:Glutathione Transferase; D005978:Glutathione; D001151:Arsenic; D019803:Glutathione Disulfide
keywords: Arsenic; Meta-analysis; Oxidative stress; Systematic review