title: An investigation of cerebrovascular lesions in dementia with Lewy bodies compared to Alzheimer's disease.
abstract: BACKGROUND
  Cerebrovascular lesions on MRI are common in Alzheimer's disease (AD) dementia, but less is known about their frequency and impact on dementia with Lewy bodies (DLB).
  
  
  METHODS
  White-matter hyperintensities (WMHs) and infarcts on MRI were assessed in consecutive DLB (n = 81) and AD dementia (n = 240) patients and compared to age-matched and sex-matched cognitively normal subjects (CN) from a population-based cohort.
  
  
  RESULTS
  DLB had higher WMH volume compared to CN, and WMH volume was higher in the occipital and posterior periventricular regions in DLB compared to AD. Higher WMH volume was associated with history of cardiovascular disease and diabetes but not with clinical disease severity in DLB. Frequency of infarcts in DLB was not different from CN and AD dementia.
  
  
  CONCLUSIONS
  In DLB, WMH volume is higher than AD and CN and appears to be primarily associated with history of vascular disease.
authors: Department of Radiology, Mayo Clinic, Rochester, MN, USA; Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy; Department of Neurology, Institute of Experimental Neurology, Division of Neuroscience, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy.
authors: Lidia
authors: L
authors: Sarro
authors: Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA.
authors: Nirubol
authors: N
authors: Tosakulwong
authors: Department of Radiology, Mayo Clinic, Rochester, MN, USA.
authors: Christopher G
authors: CG
authors: Schwarz
authors: Department of Neurology, Mayo Clinic, Rochester, MN, USA.
authors: Jonathan
authors: J
authors: Graff-Radford
authors: Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA.
authors: Scott A
authors: SA
authors: Przybelski
authors: Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA.
authors: Timothy G
authors: TG
authors: Lesnick
authors: Department of Radiology, Mayo Clinic, Rochester, MN, USA.
authors: Samantha M
authors: SM
authors: Zuk
authors: Department of Information Technology, Mayo Clinic, Rochester, MN, USA.
authors: Robert I
authors: RI
authors: Reid
authors: Department of Radiology, Mayo Clinic, Rochester, MN, USA.
authors: Mekala R
authors: MR
authors: Raman
authors: Department of Neurology, Mayo Clinic, Rochester, MN, USA.
authors: Bradley F
authors: BF
authors: Boeve
authors: Department of Psychiatry and Psychology, Mayo Clinic, Jacksonville, FL, USA.
authors: Tanis J
authors: TJ
authors: Ferman
authors: Department of Neurology, Mayo Clinic, Rochester, MN, USA.
authors: David S
authors: DS
authors: Knopman
authors: Department of Neurology, Institute of Experimental Neurology, Division of Neuroscience, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy.
authors: Giancarlo
authors: G
authors: Comi
authors: Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy; Department of Neurology, Institute of Experimental Neurology, Division of Neuroscience, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy.
authors: Massimo
authors: M
authors: Filippi
authors: Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA.
authors: Melissa E
authors: ME
authors: Murray
authors: Department of Pathology, Mayo Clinic, Rochester, MN, USA.
authors: Joseph E
authors: JE
authors: Parisi
authors: Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA.
authors: Dennis W
authors: DW
authors: Dickson
authors: Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA; Department of Neurology, Mayo Clinic, Rochester, MN, USA.
authors: Ronald C
authors: RC
authors: Petersen
authors: Department of Radiology, Mayo Clinic, Rochester, MN, USA.
authors: Clifford R
authors: CR
authors: Jack
authors: Department of Radiology, Mayo Clinic, Rochester, MN, USA. Electronic address: kantarci.kejal@mayo.edu.
authors: Kejal
authors: K
authors: Kantarci
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000150:complications* / Q000000981:diagnostic imaging / Q000473:pathology; D020520:Brain Infarction / Q000209:etiology; D016022:Case-Control Studies; D002561:Cerebrovascular Disorders / Q000209:etiology* / Q000473:pathology*; D015331:Cohort Studies; D005260:Female; D006801:Humans; D020961:Lewy Body Disease / Q000150:complications* / Q000000981:diagnostic imaging / Q000473:pathology; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D066127:White Matter / Q000000981:diagnostic imaging / Q000473:pathology*
keywords: Alzheimer's disease; Cerebrovascular disease; Dementia with Lewy bodies; Infarcts; MRI; Sex differences; White matter hyperintensities