title: Acute Lymphoblastic Leukemia Presenting With Pancytopenia Followed by a 14-Month-Long Period of Transient Remission Possibly Supporting the Adrenal Hypothesis of Leukemogenesis.
abstract: A small group of children with acute lymphoblastic leukemia (ALL) have a preleukemic phase of pancytopenia followed by a period of spontaneous remission before the diagnosis (pre-ALL). A 6-year-old girl presented with pancytopenia, fever, and myelodysplasia. Following transient remission pre-B ALL was diagnosed 14 months later. Clonal B-lineage blasts at the period of pancytopenia were identified retrospectively. The interval between pre-ALL and ALL-diagnosis was longer than previously reported. The infection was clinically severe and might have induced a significant endogenous corticosteroids production resulting in the long-lasting remission. The case supports the adrenal and the Coley's toxin hypothesis in leukemogenesis.
authors: *Department of Pediatrics ‡Cancer Cytogenetics Laboratory, Department of Hematology, Aarhus University Hospital, Aarhus †Tissue Typing Laboratory, Clinical Immunology, Copenhagen University Hospital, Copenhagen, Denmark.
authors: Line Stensig
authors: LS
authors: Lynggaard
authors: Hanne V
authors: HV
authors: Marquart
authors: Eigil
authors: E
authors: Kjeldsen
authors: Hans O
authors: HO
authors: Madsen
authors: Henrik
authors: H
authors: Hasle
mesh_terms: D000305:Adrenal Cortex Hormones / Q000096:biosynthesis / Q000502:physiology; D001402:B-Lymphocytes / Q000473:pathology; D002648:Child; D002999:Clone Cells / Q000473:pathology; D005260:Female; D006801:Humans; D008213:Lymphocyte Activation; D010198:Pancytopenia / Q000473:pathology*; D015452:Precursor B-Cell Lymphoblastic Leukemia-Lymphoma / Q000175:diagnosis* / Q000209:etiology / Q000473:pathology; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000175:diagnosis* / Q000209:etiology / Q000473:pathology; D012075:Remission, Spontaneous
chemical_list: D000305:Adrenal Cortex Hormones