title: No effect of anti-inflammatory medication on postprandial and postexercise muscle protein synthesis in elderly men with slightly elevated systemic inflammation.
abstract: Based on circulating C-reactive protein (CRP) levels, some individuals develop slightly increased inflammation as they age. In elderly inflamed rats, the muscle response to protein feeding is impaired, whereas it can be maintained by treatment with non-steroidal anti-inflammatory drugs (NSAIDs). It is unknown whether this applies to elderly humans with increased inflammation. Thus, the muscle response to whey protein bolus ingestion with and without acute resistance exercise was compared between healthy elderly individuals and elderly individuals with slightly increased inflammation±NSAID treatment.
  
  
  
  Twenty-four elderly men (>60years) were recruited. Of those, 14 displayed a slightly increased systemic inflammation (CRP>2mg/l) and were randomly assigned to NSAID (Ibuprofen 1800mg/day) or placebo treatment for 1week. The remaining 10 elderly individuals served as healthy controls (CRP<1mg/l). The muscle protein synthetic response was measured as the fractional synthetic rate (FSR) and p70S6K phosphorylation-to-total protein ratio.
  
  
  
  The basal myofibrillar FSR and the myofibrillar FSR responses to whey protein bolus ingestion with and without acute resistance exercise were maintained in inflamed elderly compared to healthy controls (p>0.05) and so was p70S6K phosphorylation. Moreover, NSAID treatment did not significantly improve the myofibrillar and connective tissue FSR responses or reduce the plasma CRP level in inflamed, elderly individuals (p>0.05).
  
  
  
  A slight increase in systemic inflammation does not affect the basal myofibrillar FSR or the myofibrillar FSR responses, which suggests that elderly individuals with slightly increased inflammation can benefit from protein ingestion and resistance exercise to stimulate muscle protein anabolism. Moreover, the NSAID treatment did not significantly affect the myofibrillar or connective tissue FSR responses to protein ingestion and acute resistance exercise.
authors: Institute of Sports Medicine Copenhagen, Department of Orthopedic Surgery M, Bispebjerg Hospital and Center for Healthy Aging, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. Electronic address: kasperjuel@hotmail.com.
authors: K
authors: K
authors: Dideriksen
authors: Institute of Sports Medicine Copenhagen, Department of Orthopedic Surgery M, Bispebjerg Hospital and Center for Healthy Aging, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; Institute of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
authors: S
authors: S
authors: Reitelseder
authors: Institute of Sports Medicine Copenhagen, Department of Orthopedic Surgery M, Bispebjerg Hospital and Center for Healthy Aging, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
authors: N M
authors: NM
authors: Malmgaard-Clausen
authors: Institute of Sports Medicine Copenhagen, Department of Orthopedic Surgery M, Bispebjerg Hospital and Center for Healthy Aging, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; Institute of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
authors: R
authors: R
authors: Bechshoeft
authors: Department of Biology, Faculty of Science, University of Copenhagen, Copenhagen, Denmark.
authors: R K
authors: RK
authors: Petersen
authors: Institute of Sports Medicine Copenhagen, Department of Orthopedic Surgery M, Bispebjerg Hospital and Center for Healthy Aging, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
authors: U R
authors: UR
authors: Mikkelsen
authors: Institute of Sports Medicine Copenhagen, Department of Orthopedic Surgery M, Bispebjerg Hospital and Center for Healthy Aging, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; Institute of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
authors: L
authors: L
authors: Holm
mesh_terms: D000368:Aged; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage*; D001823:Body Composition; D002097:C-Reactive Protein / Q000032:analysis; D003430:Cross-Sectional Studies; D003718:Denmark; D004311:Double-Blind Method; D006801:Humans; D007052:Ibuprofen / Q000008:administration & dosage*; D007249:Inflammation / Q000378:metabolism*; D007328:Insulin / Q000097:blood; D015850:Interleukin-6 / Q000097:blood; D007930:Leucine / Q000097:blood; D016014:Linear Models; D008297:Male; D009124:Muscle Proteins / Q000096:biosynthesis* / Q000187:drug effects; D009210:Myofibrils / Q000187:drug effects / Q000378:metabolism*; D010649:Phenylalanine / Q000097:blood; D019518:Postprandial Period; D051381:Rats; D055070:Resistance Training; D038762:Ribosomal Protein S6 Kinases, 70-kDa / Q000032:analysis
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; C508600:IL6 protein, human; D007328:Insulin; D015850:Interleukin-6; D009124:Muscle Proteins; D010649:Phenylalanine; D002097:C-Reactive Protein; D038762:Ribosomal Protein S6 Kinases, 70-kDa; D007930:Leucine; D007052:Ibuprofen
keywords: Anabolic resistance; Appendicular lean mass; CRP; IL-6; Ibuprofen; Low-grade inflammation; NSAID; p70S6K