title: Soluble Urokinase Receptors in Focal Segmental Glomerulosclerosis: A Review on the Scientific Point of View.
abstract: Focal segmental glomerulosclerosis (FSGS) is one of the primary glomerular disorders in both children and adults which can progress to end-stage renal failure. Although there are genetic and secondary causes, circulating factors have also been regarded as an important factor in the pathogenesis of FSGS, because about 40% of the patients with FSGS have recurrence after renal transplantation. Soluble urokinase-type plasminogen activator receptor (suPAR) is a soluble form of uPAR, which is a membrane-bound protein linked to GPI in various immunologically active cells, including podocytes. It has recently been suggested as a potential circulating factor in FSGS by in vitro podocyte experiments, in vivo mice models, and human studies. However, there have also been controversies on this issue, because subsequent studies showed conflicting results. suPAR levels were also increased in patients with other glomerular diseases and were inversely correlated with estimated glomerular filtration rate. Nevertheless, there has been no balanced review on this issue. In this review, we compare the conflicting data on the involvement of suPAR in the pathogenesis of FSGS and shed light on interpretation by taking into account many points and the potential variables and confounders influencing serum suPAR levels.
authors: Medical University Innsbruck, Anichstraße 35, 6020 Innsbruck, Austria.
authors: Andreas
authors: 0000-0002-2945-2946
authors: A
authors: Kronbichler
authors: Children's and Academic Renal Unit, University of Bristol, Dorothy Hodgkin Building, Bristol BS2 8BJ, UK.
authors: Moin A
authors: MA
authors: Saleem
authors: Department of Microbiology and Immunology, KU Leuven and Department of Nephrology, UZ Leuven, 3000 Leuven, Belgium.
authors: Björn
authors: B
authors: Meijers
authors: Department of Pediatric Nephrology, Yonsei University College of Medicine, Severance Children's Hospital, Seoul 120-752, Republic of Korea.
authors: Jae Il
authors: 0000-0003-2326-1820
authors: JI
authors: Shin
mesh_terms: D000818:Animals; D015415:Biomarkers; D004195:Disease Models, Animal; D004198:Disease Susceptibility; D005923:Glomerulosclerosis, Focal Segmental / Q000097:blood* / Q000175:diagnosis / Q000209:etiology*; D006801:Humans; D056747:Immunomodulation; D016023:Integrins / Q000378:metabolism; D008024:Ligands; D050199:Podocytes / Q000378:metabolism; D011485:Protein Binding; D011507:Proteinuria / Q000209:etiology / Q000378:metabolism; D055293:Receptors, Urokinase Plasminogen Activator / Q000097:blood* / Q000235:genetics; D015398:Signal Transduction; D014568:Urokinase-Type Plasminogen Activator / Q000097:blood
chemical_list: D015415:Biomarkers; D016023:Integrins; D008024:Ligands; D055293:Receptors, Urokinase Plasminogen Activator; D014568:Urokinase-Type Plasminogen Activator