title: Study of seven single-nucleotide polymorphisms identified in East Asians for association with obesity in a Taiwanese population.
abstract: This study aimed to examine single-nucleotide polymorphisms (SNPs) of seven previously reported obesity genes in East Asians and to analyse their associations and synergistic effects on obesity in the Taiwanese population.
  
  
  
  Cross-sectional study.
  
  
  
  One medical centre in northern Taiwan.
  
  
  
  A total of 323 non-obese and 264 obese participants were recruited. The threshold for obesity in this study was a body mass index of ≥27 kg/m(2), as defined by the Ministry of Health and Welfare in Taiwan. The study was performed with the approval of the institutional review board of MacKay Memorial Hospital, Taipei, Taiwan (application number 12MMHIS106).
  
  
  
  We analysed the genotype distributions of seven SNPs localising to the PPARγ2, GNB3, SDC3, ADRB2, FTO, PPARγ and ESR1 genes in obese and non-obese groups and then paired obesity-related SNPs to determine if they have synergistic effects on obesity.
  
  
  
  Analysis of the genotype distributions in obese and non-obese groups revealed only a significant positive correlation between an SNP in rs2282440-syndecan 3 (SDC3) and obesity in the Taiwanese population (p=0.006). In addition, the T/T genotype of SDC3 was significantly associated with a larger waist and hip circumference, higher body fat percentage and lower high-density lipoprotein cholesterol. Moreover, the combination of the rs2282440-SDC3T/T genotype with the rs1801282-peroxisome proliferator-activated receptor-gamma2 gene (PPARγ2) G carrier genotype was strongly associated with obesity (OR=6.77).
  
  
  
  We found that the rs2282440-SDC3T/T genotype is associated with obesity in the Taiwanese population. Furthermore, there is a synergistic effect of the high-risk alleles of the SDC3 and PPARγ2 genes on the obese phenotype in the Taiwanese population.
  
  
  
  12MMHIS106; Results.
authors: Department of Family Medicine, Mackay Memorial Hospital, Taipei, Taiwan Department of Medicine, Mackay Medical College, Taipei, Taiwan.
authors: Wei-Hsin
authors: WH
authors: Huang
authors: Department of Family Medicine, Mackay Memorial Hospital, Taipei, Taiwan Department of Medicine, Mackay Medical College, Taipei, Taiwan Mackay Junior College of Medicine, Nursing and Management, Taipei, Taiwan.
authors: Lee-Ching
authors: LC
authors: Hwang
authors: Department of Family Medicine, Mackay Memorial Hospital, Taipei, Taiwan Department of Medicine, Mackay Medical College, Taipei, Taiwan.
authors: Hsin-Lung
authors: HL
authors: Chan
authors: Department of Medicine, Mackay Medical College, Taipei, Taiwan Mackay Junior College of Medicine, Nursing and Management, Taipei, Taiwan Department of Pediatrics, Mackay Memorial Hospital, Taipei, Taiwan.
authors: Hsiang-Yu
authors: HY
authors: Lin
authors: Department of Research and Development, TCI Gene INC, Taipei, Taiwan.
authors: Yung-Hsiang
authors: YH
authors: Lin
mesh_terms: D000328:Adult; D000368:Aged; D000483:Alleles; D000071516:Alpha-Ketoglutarate-Dependent Dioxygenase FTO / Q000235:genetics; D044466:Asian People / Q000235:genetics*; D015992:Body Mass Index; D008076:Cholesterol, HDL / Q000097:blood; D003430:Cross-Sectional Studies; D047628:Estrogen Receptor alpha / Q000235:genetics; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D020962:Heterotrimeric GTP-Binding Proteins / Q000235:genetics; D006801:Humans; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000097:blood / Q000235:genetics*; D047495:PPAR gamma / Q000235:genetics; D020641:Polymorphism, Single Nucleotide; D018343:Receptors, Adrenergic, beta-2 / Q000235:genetics; D053670:Syndecan-3 / Q000235:genetics; D013624:Taiwan; D055815:Young Adult
chemical_list: C553443:ADRB2 protein, human; D008076:Cholesterol, HDL; C506487:ESR1 protein, human; D047628:Estrogen Receptor alpha; C000595803:GNB3 protein, human; D047495:PPAR gamma; D018343:Receptors, Adrenergic, beta-2; C508301:SDC3 protein, human; D053670:Syndecan-3; D000071516:Alpha-Ketoglutarate-Dependent Dioxygenase FTO; C526492:FTO protein, human; D020962:Heterotrimeric GTP-Binding Proteins
keywords: Obesity genes; PPARγ2; single nucleotide polymorphisms; syndecan 3