title: [Radiotherapy of hypopharynx cancers].
abstract: The intensity-modulated radiotherapy is the gold standard in the treatment of hypopharynx cancers. Early T1 and T2 tumours could be treated by exclusive radiotherapy or surgery. For tumours requiring total pharyngolaryngectomy (T2 or T3), induction chemotherapy followed by exclusive radiotherapy or concurrent chemoradiotherapy are possible. For T4 tumours, surgery must be proposed. The treatment of lymph nodes is based on the initial treatment of the primary tumour. In non-surgical procedure, in case of sequential radiotherapy, curative dose is 70Gy and prophylactic dose is 50Gy. An integrated simultaneous boost radiotherapy is allowed (70Gy in 2Gy per fraction and 56Gy in 1.8Gy per fraction or 70Gy in 2.12Gy per fraction). Postoperatively, radiotherapy is used for locally advanced cancers with dose levels based on pathologic criteria (66Gy for R1 resection, 50 to 54Gy for complete resection). Volume delineation is based on guidelines.
authors: Centre Jean-Bernard, clinique Victor-Hugo (Institut interrégional de cancérologie), 9, rue Beauverger, 72000 Le-Mans, France; Service de radiothérapie, centre régional universitaire de cancérologie Henry-S.-Kaplan, hôpital Bretonneau, CHRU de Tours, 2, boulevard Tonnellé, 37044 Tours, France. Electronic address: pointr_y@yahoo.fr.
authors: Y
authors: Y
authors: Pointreau
authors: Centre Jean-Bernard, clinique Victor-Hugo (Institut interrégional de cancérologie), 9, rue Beauverger, 72000 Le-Mans, France.
authors: C
authors: C
authors: Lafond
authors: Centre Jean-Bernard, clinique Victor-Hugo (Institut interrégional de cancérologie), 9, rue Beauverger, 72000 Le-Mans, France.
authors: P
authors: P
authors: Trémolières
authors: Centre Jean-Bernard, clinique Victor-Hugo (Institut interrégional de cancérologie), 9, rue Beauverger, 72000 Le-Mans, France.
authors: F
authors: F
authors: Legouté
authors: Département de radiothérapie, institut Jean-Godinot, 1, rue Koenig, 51056 Reims, France.
authors: S
authors: S
authors: Servagi-Vernat
authors: Service d'oncologie radiothérapie, hôpital européen Georges-Pompidou, 20, rue Leblanc, 75015 Paris, France; Université Paris-Descartes, Sorbonne Paris-Cité, 12, rue de l'École-de-Médecine, 75006 Paris, France.
authors: P
authors: P
authors: Giraud
authors: Département de radiothérapie, centre Georges-François-Leclerc, 1, rue Professeur-Marion, 21079 Dijon, France.
authors: P
authors: P
authors: Maingon
authors: Service de radiothérapie, centre régional universitaire de cancérologie Henry-S.-Kaplan, hôpital Bretonneau, CHRU de Tours, 2, boulevard Tonnellé, 37044 Tours, France.
authors: G
authors: G
authors: Calais
authors: Département de radiothérapie, centre Jean-Perrin, 58, rue Montalembert, BP 5026, 63011 Clermont-Ferrand cedex 1, France.
authors: M
authors: M
authors: Lapeyre
mesh_terms: D059248:Chemoradiotherapy; D003131:Combined Modality Therapy; D019583:Dose Fractionation, Radiation; D006801:Humans; D007012:Hypopharyngeal Neoplasms / Q000188:drug therapy / Q000532:radiotherapy* / Q000601:surgery; D015182:Lymphatic Irradiation; D008207:Lymphatic Metastasis; D058958:Organs at Risk; D011832:Radiation Injuries / Q000517:prevention & control; D011879:Radiotherapy Dosage; D011880:Radiotherapy Planning, Computer-Assisted; D018714:Radiotherapy, Adjuvant / Q000379:methods; D061089:Radiotherapy, Image-Guided / Q000379:methods; D050397:Radiotherapy, Intensity-Modulated / Q000009:adverse effects / Q000379:methods* / Q000592:standards
keywords: Delineation; Dose; Doses; Délinéation; Hypopharynx cancer; Indication; Indications; Intensity-modulated radiotherapy; Radiothérapie conformationnelle avec modulation d’intensité; Tumeurs hypopharyngées