title: Angiogenic imbalance as a contributor to the pathophysiology of preeclampsia among black African women.
abstract: OBJECTIVE
  The pathogenesis of preeclampsia remains unclear despite extensive research. Altered angiogenic balance has been hypothesized to play a significant role in the clinical manifestations of this syndrome. However this imbalance has not been investigated extensively among black African women. The aim of this study was to investigate the maternal levels of the angiogenic factors soluble vascular endothelial growth factor receptor 1 (sFLT1) and placental growth factor (PlGF) among black African women with preeclampsia.
  
  
  METHODS
  A case control study was conducted in the Mthatha hospital complex in South Africa including 51 women with preeclampsia and 82 women with uncomplicated pregnancies. Blood samples were drawn from participants and serum was used to assess sFLT1, and PlGF levels quantified using specific enzyme linked immunosorbent assays. Non- parametric statistics were used for analysis.
  
  
  RESULTS
  Black African women with preeclampsia were found to have significantly lower levels of PlGF (90.3 ± 8.9 pg/ml versus 172.8 ± 20.2 pg/ml; p < 0.01), higher sFLT1 (2087.3 ± 200.1 pg/ml versus 1546.5 ± 91.9 pg/ml; p < 0.01) and a higher sFLT1/PIGF ratio (66.8 ± 18.7 versus 22.3 ± 2.9; p < 0.01) compared to black African normotensive controls.
  
  
  CONCLUSIONS
  The results support an altered angiogenic balance may contribute to the pathogenesis/pathophysiology of preeclampsia among black African women as reported in other populations.
authors: a Division of Physiology , Department of Human Biology, Walter Sisulu University , Mthatha, Eastern Cape Province , South Africa and.
authors: Allen
authors: A
authors: Meeme
authors: b Department of Obstetrics and Gynaecology , Walter Sisulu University , Mthatha, Eastern Cape Province , South Africa.
authors: Geoffrey A
authors: GA
authors: Buga
authors: a Division of Physiology , Department of Human Biology, Walter Sisulu University , Mthatha, Eastern Cape Province , South Africa and.
authors: MaryKutty
authors: M
authors: Mammen
authors: a Division of Physiology , Department of Human Biology, Walter Sisulu University , Mthatha, Eastern Cape Province , South Africa and.
authors: Ambrose V
authors: AV
authors: Namugowa
mesh_terms: D000328:Adult; D043925:Angiogenesis Inducing Agents / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D044383:Black People; D016022:Case-Control Studies; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D000072483:Placenta Growth Factor / Q000097:blood*; D011225:Pre-Eclampsia / Q000097:blood* / Q000208:ethnology; D011247:Pregnancy; D018709:Statistics, Nonparametric; D040281:Vascular Endothelial Growth Factor Receptor-1 / Q000097:blood*
chemical_list: D043925:Angiogenesis Inducing Agents; D015415:Biomarkers; C000608036:PGF protein, human; D000072483:Placenta Growth Factor; D040281:Vascular Endothelial Growth Factor Receptor-1
keywords: Angiogenic factors; black African women; placental growth factor; preeclampsia; soluble vascular endothelial growth factor 1