title: Association of Ambient Air Pollution with Depressive and Anxiety Symptoms in Older Adults: Results from the NSHAP Study.
abstract: Ambient fine particulate matter (PM2.5) is among the most prevalent sources of environmentally induced inflammation and oxidative stress, both of which are implicated in the pathogenesis of most mental disorders. Evidence, however, concerning the impact of PM2.5on mental health is just emerging.
  
  
  
  We examined the association between PM2.5and current level of depressive and anxiety symptoms using a nationally representative probability sample (n= 4,008) of older, community-dwelling individuals living across the United States (the National Social Life, Health and Aging project).
  
  
  
  Mental health was evaluated using validated, standardized questionnaires and clinically relevant cases were identified using well-established cutoffs; daily PM2.5estimates were obtained using spatiotemporal models. We used generalized linear mixed models, adjusting for potential confounders, and explored effect modification.
  
  
  
  An increase in PM2.5was significantly associated with anxiety symptoms, with the largest increase for 180-days moving average (OR = 1.61; 95% CI: 1.35, 1.92) after adjusting for socioeconomic measures (SES); PM2.5was positively associated with depressive symptoms, and significantly for 30-day moving average (OR = 1.16; 95% CI: 1.05, 1.29) upon SES adjustment. The observed associations were enhanced among individuals who had low SES and history of comorbidity. When considering mental health as chronic conditions, PM2.5was significantly associated with incident depressive symptoms for all exposure windows examined, but with incident anxiety symptoms only for shorter exposure windows, which may be due to a drop in power resulting from the decreased between-subject variability in chronic PM2.5exposure.
  
  
  
  PM2.5was associated with depressive and anxiety symptoms, with associations the strongest among individuals with lower SES or among those with certain health-related characteristics. Citation: Pun VC, Manjourides J, Suh H. 2017. Association of ambient air pollution with depressive and anxiety symptoms in older adults: results from the NSHAP study. Environ Health Perspect 125:342-348; http://dx.doi.org/10.1289/EHP494.
authors: Department of Health Sciences, Northeastern University, Boston, Massachusetts, USA.
authors: Vivian C
authors: VC
authors: Pun
authors: Justin
authors: J
authors: Manjourides
authors: Helen
authors: H
authors: Suh
mesh_terms: D000368:Aged; D000393:Air Pollutants / Q000032:analysis; D000397:Air Pollution / Q000706:statistics & numerical data*; D001007:Anxiety / Q000453:epidemiology*; D015331:Cohort Studies; D003863:Depression / Q000453:epidemiology*; D004781:Environmental Exposure / Q000032:analysis / Q000706:statistics & numerical data*; D006801:Humans; D052638:Particulate Matter / Q000032:analysis*
chemical_list: D000393:Air Pollutants; D052638:Particulate Matter