title: Small intestine contrast ultrasonography for the detection and assessment of Crohn disease: A meta-analysis.
abstract: BACKGROUND
  Crohn disease (CD) is a chronic relapsing disease. Imaging modalities are essential for the diagnosis and assessment of CD. Small intestine contrast ultrasonography (SICUS) is a well-tolerated, noninvasive and radiation-free modality and has shown potential in CD assessment. We aimed at evaluating the diagnostic accuracy of SICUS in the detection and assessment of small-bowel lesions and complications in CD.
  
  
  METHODS
  We searched PubMed database for relevant studies published before April 24, 2016. We integrated the true positive, false positive, false negative, and true negative into the pooled estimates of sensitivity, specificity, positive likelihood ratio, negative likelihood ratio, and diagnostic odds ratio. Forest plots were to represent the pooled results of all studies.
  
  
  RESULTS
  Thirteen articles were finally considered eligible. The pooled sensitivity and specificity of SICUS in detecting small-bowel lesions were 0.883 (95% confidence interval (CI) 0.847-0.913) and 0.861 (95% CI 0.828-0.890), respectively. The pooled diagnostic odds ratio was 39.123 (95% CI 20.014-76.476) and the area under the curve of summary receiver operating characteristic was 0.9273 (standard error: 0.0152). In subgroup analyses, SICUS represented fine sensitivity and specificity in proximal and distal small intestine lesion, as well as in CD-related complications such as stricture, dilation, abscess, and fistula.
  
  
  CONCLUSIONS
  SICUS is accurate enough to make a complete assessment about the location, extent, number, and almost all kinds of complications in CD small-bowel lesions.
authors: State Key Laboratory of Biotherapy and Cancer Center, West China Hospital West China School of Medicine, Sichuan University, Chengdu Gansu Province Wuwei Cancer Hospital, P.R. China.
authors: Chenjing
authors: C
authors: Zhu
authors: Xuelei
authors: X
authors: Ma
authors: Luqi
authors: L
authors: Xue
authors: Jing
authors: J
authors: Xu
authors: Qingfang
authors: Q
authors: Li
authors: Yun
authors: Y
authors: Wang
authors: Jing
authors: J
authors: Zhang
mesh_terms: D003287:Contrast Media; D003424:Crohn Disease / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000503:physiopathology; D005260:Female; D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D007421:Intestine, Small / Q000473:pathology*; D008297:Male; D012680:Sensitivity and Specificity; D012720:Severity of Illness Index; D018608:Ultrasonography, Doppler / Q000379:methods*
chemical_list: D003287:Contrast Media