title: Persistent Luminescent Nanocarrier as an Accurate Tracker in Vivo for Near Infrared-Remote Selectively Triggered Photothermal Therapy.
abstract: Optical imaging-guidance of indocyanine green (ICG) for photothermal therapy (PTT) has great latent capacity in cancer therapy. However, the conventional optical image-guidance mode has caused strong tissue autofluorescence of the living tissue, which leads to the accurate infrared light irradiation cannot be conducted. In this article, ICG and persistent luminescence phosphors (PLPs) coloaded mesoporous silica nanocarriers ((ICG+PLPs)@mSiO2) were first designed and prepared for persistent luminescent imaging-guided PTT. The (ICG+PLPs)@mSiO2 nanocarriers could significantly improve signal-to-noise ratio during luminescence imaging-guided PTT, making the PLP promising for improving the accuracy of the tumor site for photothermal therapy in vivo. This paper is likely to develop a new way for accurately regulating cancer cell death based on luminescence imaging-guided PTT selectively triggered by near-infrared (NIR)-remote.
authors: School of Life Sciences, Tianjin University , Tianjin Engineering Center for Micro-Nano Biomaterials and Detection-Treatment Technology, 92 Weijin Road, Nankai District, Tianjin 300072, P.R. China.
authors: Bin
authors: B
authors: Zheng
authors: School of Life Sciences, Tianjin University , Tianjin Engineering Center for Micro-Nano Biomaterials and Detection-Treatment Technology, 92 Weijin Road, Nankai District, Tianjin 300072, P.R. China.
authors: Hong-Bin
authors: HB
authors: Chen
authors: Department of Lymphoma, Tianjin Medical University Cancer Institute and Hospital , National Clinical Research Center of Cancer, Sino-US Center for Lymphoma and Leukemia, Key Laboratory of Cancer Prevention and Therapy, Tianjin 300060, China.
authors: Pei-Qi
authors: PQ
authors: Zhao
authors: School of Life Sciences, Tianjin University , Tianjin Engineering Center for Micro-Nano Biomaterials and Detection-Treatment Technology, 92 Weijin Road, Nankai District, Tianjin 300072, P.R. China.
authors: Hui-Zhuo
authors: HZ
authors: Pan
authors: School of Life Sciences, Tianjin University , Tianjin Engineering Center for Micro-Nano Biomaterials and Detection-Treatment Technology, 92 Weijin Road, Nankai District, Tianjin 300072, P.R. China.
authors: Xiao-Li
authors: XL
authors: Wu
authors: School of Life Sciences, Tianjin University , Tianjin Engineering Center for Micro-Nano Biomaterials and Detection-Treatment Technology, 92 Weijin Road, Nankai District, Tianjin 300072, P.R. China.
authors: Xiao-Qun
authors: XQ
authors: Gong
authors: School of Life Sciences, Tianjin University , Tianjin Engineering Center for Micro-Nano Biomaterials and Detection-Treatment Technology, 92 Weijin Road, Nankai District, Tianjin 300072, P.R. China.
authors: Han-Jie
authors: HJ
authors: Wang
authors: School of Life Sciences, Tianjin University , Tianjin Engineering Center for Micro-Nano Biomaterials and Detection-Treatment Technology, 92 Weijin Road, Nankai District, Tianjin 300072, P.R. China.
authors: Jin
authors: J
authors: Chang
mesh_terms: D007208:Indocyanine Green; D049449:Luminescence; D049329:Nanostructures; D010789:Phototherapy; D012822:Silicon Dioxide
chemical_list: D012822:Silicon Dioxide; D007208:Indocyanine Green
keywords: indocyanine green (ICG); luminescent nanoprobes; near-infrared light (NIR); persistent luminescence phosphors (PLPs); photothermal therapy (PTT)