title: Association of HLA-DRB1 Gene Polymorphism with Risk of Asthma: A Meta-Analysis.
abstract: BACKGROUND The relationship between HLA-DRB1 alleles and asthma is controversial. The purpose of this study was to evaluate the relationship between HLA-DRB1 alleles and risk of asthma. MATERIAL AND METHODS We searched PubMed, Chinese National Knowledge Infrastructure (CNKI), Wan Fang (Chinese) database, and Chinese Biomedical Medical databases (CBM) to find studies on the relationship between HLA-DRB1 alleles and risk of asthma. We calculated the pooled odds ratio (OR) and 95% confidence interval (CI) using STATA 12.0. Finally, a total of 24 studies were included in this meta-analysis. RESULTS The results revealed that DRB1*03 was positively associated with risk of asthma (OR=1.51, 95%CI=1.27-1.80), and DRB1*15 was negatively associated with risk of asthma (OR=0.63, 95%CI=0.42-0.93), but no association was found in other HLA-DRB1 alleles. Subgroup analysis by age revealed that DRB1*03, DRB1*04, DRB1*09, and DRB1*15 were associated with asthma in children. Subgroup analysis by ethnicity showed that DRB1*03 and DRB1*15 were associated with asthma in whites, and DRB1*07 and DRB1*14 were associated with asthma in Asians. CONCLUSIONS This results of this meta-analysis suggest that HLA-DRB1 alleles are associated with asthma.
authors: School of Public Health, Wannan Medical College, Wuhu, Anhui, China (mainland).
authors: Yingshui
authors: Y
authors: Yao
authors: School of Public Health, Wannan Medical College, Wuhu, Anhui, China (mainland).
authors: Lijun
authors: L
authors: Zhu
authors: School of Public Health, Wannan Medical College, Wuhu, Anhui, China (mainland).
authors: Jie
authors: J
authors: Li
authors: School of Public Health, Wannan Medical College, Wuhu, Anhui, China (mainland).
authors: Yuelong
authors: Y
authors: Jin
authors: School of Public Health, Wannan Medical College, Wuhu, Anhui, China (mainland).
authors: Lianping
authors: L
authors: He
mesh_terms: D000483:Alleles; D001249:Asthma / Q000235:genetics*; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D059811:HLA-DRB1 Chains / Q000235:genetics* / Q000378:metabolism; D006801:Humans; D008297:Male; D011110:Polymorphism, Genetic / Q000235:genetics
chemical_list: D059811:HLA-DRB1 Chains
keywords: Anti-Asthmatic Agents; HLA Antigens; Polymorphism, Single Nucleotide; meta-analysis