title: A novel ureteral stent material with antibacterial and reducing encrustation properties.
abstract: Ureteral stents have been used to relieve ureterostenosis. Complications such as infection and encrustation occur in the long time of stent implantation, which is a clinical problem needs to be resolved. Indwelling ureteral stents have shown to develop microbial biofilm that may lead to recurrent infection and encrustation. This study was aiming to reduce those complications by using a novel material, Cu-bearing antibacterial stainless steel. The antibacterial performance, encrustation property, and biocompatibility were examined by SEM, image analysis, MTT and would healing. The in vitro immersion test showed that 316LCu-bearing stainless steel (316LCu-SS) not only inhibited proliferation of bacteria and formation of biofilm, but also had less encrustation deposition. Its antibacterial effectiveness against Escherichia coli reached to 92.7% in the artificial urine for 24h and 90.3% in the human urine for 6h. The encrustation surface coverage percentage was 30.2% by 12weeks, which was nearly one half of NiTi alloy. The in vitro tests showed that 316LCu-SS had no toxicity, and promoted the migration of urethral epithelial cells.
authors: Institute of Metal Research, Chinese Academy of Sciences, Shenyang 110016, China.
authors: Jing
authors: J
authors: Zhao
authors: General Hospital of Shenyang Military Region, Shenyang 110840, China.
authors: Zhiqiang
authors: Z
authors: Cao
authors: Institute of Metal Research, Chinese Academy of Sciences, Shenyang 110016, China.
authors: Ling
authors: L
authors: Ren
authors: Institute of Metal Research, Chinese Academy of Sciences, Shenyang 110016, China.
authors: Shanshan
authors: S
authors: Chen
authors: Institute of Metal Research, Chinese Academy of Sciences, Shenyang 110016, China.
authors: Bingchun
authors: B
authors: Zhang
authors: Institute of Metal Research, Chinese Academy of Sciences, Shenyang 110016, China.
authors: Rui
authors: R
authors: Liu
authors: Institute of Metal Research, Chinese Academy of Sciences, Shenyang 110016, China. Electronic address: kyang@imr.ac.cn.
authors: Ke
authors: K
authors: Yang
mesh_terms: D018441:Biofilms / Q000254:growth & development*; D002460:Cell Line; D003300:Copper / Q000737:chemistry*; D004847:Epithelial Cells / Q000378:metabolism / Q000382:microbiology / Q000473:pathology; D004926:Escherichia coli / Q000502:physiology*; D006801:Humans; D008422:Materials Testing; D013193:Stainless Steel / Q000737:chemistry*; D015607:Stents / Q000382:microbiology*; D014521:Urethra / Q000378:metabolism / Q000382:microbiology / Q000473:pathology
chemical_list: D013193:Stainless Steel; D003300:Copper
keywords: Antibacterial; Cu-bearing stainless steel; Encrustation; Infection; Ureteral stent