title: Network biology concepts in complex disease comorbidities.
abstract: The co-occurrence of diseases can inform the underlying network biology of shared and multifunctional genes and pathways. In addition, comorbidities help to elucidate the effects of external exposures, such as diet, lifestyle and patient care. With worldwide health transaction data now often being collected electronically, disease co-occurrences are starting to be quantitatively characterized. Linking network dynamics to the real-life, non-ideal patient in whom diseases co-occur and interact provides a valuable basis for generating hypotheses on molecular disease mechanisms, and provides knowledge that can facilitate drug repurposing and the development of targeted therapeutic strategies.
authors: Novo Nordisk Foundation Center for Protein Research, University of Copenhagen, Copenhagen DK-2200, Denmark.
authors: Jessica Xin
authors: JX
authors: Hu
authors: Novo Nordisk Foundation Center for Protein Research, University of Copenhagen, Copenhagen DK-2200, Denmark.
authors: Cecilia Engel
authors: CE
authors: Thomas
authors: Novo Nordisk Foundation Center for Protein Research, University of Copenhagen, Copenhagen DK-2200, Denmark.|Copenhagen University Hospital, Rigshospitalet, Blegdamsvej 9, Copenhagen DK-2100, Denmark.
authors: Søren
authors: S
authors: Brunak
mesh_terms: D015897:Comorbidity; D019295:Computational Biology / Q000379:methods*; D004194:Disease / Q000235:genetics*; D006801:Humans; D053858:Metabolic Networks and Pathways; D049490:Systems Biology / Q000379:methods