title: Catalyst-Free Difunctionalization of Activated Alkenes in Water: Efficient Synthesis of β-Keto Sulfides and Sulfones.
abstract: Difunctionalization of activated alkenes, a powerful strategy in chemical synthesis, has been accomplished for direct synthesis of a series of β-keto sulfides and β-keto sulfones. The transformation, mediated by O2 , proceeds smoothly in water and without any catalyst. Prominent advantages of this method include mild reaction conditions, purification simplicity, and gram-scale synthesis, underlining the practical utility of this methodology.
authors: College of Chemistry and Molecular Sciences, The Institute for Advanced Studies (IAS), Wuhan University, Wuhan, 430072, Hubei, P. R. China.
authors: Huamin
authors: H
authors: Wang
authors: College of Chemistry and Molecular Sciences, The Institute for Advanced Studies (IAS), Wuhan University, Wuhan, 430072, Hubei, P. R. China.
authors: Guangyu
authors: G
authors: Wang
authors: College of Chemistry and Molecular Sciences, The Institute for Advanced Studies (IAS), Wuhan University, Wuhan, 430072, Hubei, P. R. China.
authors: Qingquan
authors: Q
authors: Lu
authors: College of Chemistry and Molecular Sciences, The Institute for Advanced Studies (IAS), Wuhan University, Wuhan, 430072, Hubei, P. R. China.
authors: Chien-Wei
authors: CW
authors: Chiang
authors: College of Chemistry and Molecular Sciences, The Institute for Advanced Studies (IAS), Wuhan University, Wuhan, 430072, Hubei, P. R. China.
authors: Pan
authors: P
authors: Peng
authors: College of Chemistry and Molecular Sciences, The Institute for Advanced Studies (IAS), Wuhan University, Wuhan, 430072, Hubei, P. R. China.
authors: Jiufu
authors: J
authors: Zhou
authors: College of Chemistry and Molecular Sciences, The Institute for Advanced Studies (IAS), Wuhan University, Wuhan, 430072, Hubei, P. R. China. aiwenlei@whu.edu.cn.|National Research Center for Carbohydrate Synthesis, Jiangxi Normal University, Nanchang, 330022, Jiangxi, P. R. China. aiwenlei@whu.edu.cn.
authors: Aiwen
authors: http://orcid.org/0000-0001-8417-3061
authors: A
authors: Lei
keywords: aerobic oxidation; alkenes; ketones; sulfides; water