title: Prevalence and quantification of geographic atrophy associated with newly diagnosed and treatment-naïve exudative age-related macular degeneration.
abstract: To identify and quantify geographic atrophy (GA) associated with neovascular age-related macular degeneration (AMD) at initial presentation using a fundus autofluorescence (FAF) semi-automated software and to correlate the results with demographic and clinical data.
  
  
  
  Retrospective, observational study.
  
  
  
  The study population consisted of treatment-naïve patients with newly diagnosed neovascular AMD. Best-corrected visual acuity, fundus photographs, infrared reflectance, FAF and spectral-domain optical coherence tomography were performed, associated with fluorescein and indocyanine green angiographies. Identification of GA was independently performed by three readers. Quantification of atrophy areas was done using RegionFinder Software (RFA), a semi-automated software embedded in Spectralis device (Heidelberg Engineering, Germany).
  
  
  
  We included 206 eyes of 173 consecutive patients (72% female, mean age: 79.7±9.1 years). Type I choroidal neovascularisation (CNV) was observed in 44.2% of eyes, type II CNV was observed in 20.9% and mixed CNV lesion was observed in 11.7%. Polypoidal choroidal vasculopathy was diagnosed in 7.7% and type III CNV was diagnosed in 15.5%. Analysis of FAF frames showed that GA was associated with nAMD in 46/206 eyes (22.3%). Taking into account data both from Region Finder and multimodal imaging, our results suggest that GA was present in 24.3% of eyes newly diagnosed with exudative AMD. Mean size of GA was 1.23±1.76 mm2(range 0.03-7.39).
  
  
  
  GA is associated with nAMD in 1/4 of cases at initial presentation. Combined imaging, including RFA is an effective tool to identify and quantify GA at diagnosis.
authors: Department of Ophthalmology, University Paris Est, Centre Hospitalier Intercommunal de Creteil, Creteil, France.
authors: Anne
authors: A
authors: Sikorav
authors: Department of Ophthalmology, University Paris Est, Centre Hospitalier Intercommunal de Creteil, Creteil, France.
authors: Oudy
authors: O
authors: Semoun
authors: Department of Ophthalmology, University Hospital Zurich, Zurich, Switzerland.
authors: Sandrine
authors: S
authors: Zweifel
authors: Clinical Research Center, University Paris Est Creteil, Centre Hospitalier intercommunal de Creteil, Creteil, France.
authors: Camille
authors: C
authors: Jung
authors: Department of Ophthalmology, University Paris Est, Centre Hospitalier Intercommunal de Creteil, Creteil, France.
authors: Mayer
authors: M
authors: Srour
authors: Department of Ophthalmology, University Paris Est, Centre Hospitalier Intercommunal de Creteil, Creteil, France.|Department of Ophthalmology, University Vita Salute, San Raffaele Scientific Institute, Milan, Italy.
authors: Giuseppe
authors: G
authors: Querques
authors: Department of Ophthalmology, University Paris Est, Centre Hospitalier Intercommunal de Creteil, Creteil, France.
authors: Eric H
authors: EH
authors: Souied
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D020256:Choroidal Neovascularization / Q000000981:diagnostic imaging / Q000453:epidemiology / Q000473:pathology; D005451:Fluorescein Angiography; D005602:France / Q000453:epidemiology; D057092:Geographic Atrophy / Q000175:diagnosis / Q000000981:diagnostic imaging* / Q000453:epidemiology* / Q000473:pathology; D006801:Humans; D015995:Prevalence; D012189:Retrospective Studies; D041623:Tomography, Optical Coherence; D014792:Visual Acuity
keywords: Macula; Neovascularisation; Retina