title: The mammalian blastema: regeneration at our fingertips.
abstract: In the mouse, digit tip regeneration progresses through a series of discrete stages that include inflammation, histolysis, epidermal closure, blastema formation, and redifferentiation. Recent studies reveal how each regenerative stage influences subsequent stages to establish a blastema that directs the successful regeneration of a complex mammalian structure. The focus of this review is on early events of healing and how an amputation wound transitions into a functional blastema. The stepwise formation of a mammalian blastema is proposed to provide a model for how specific targeted treatments can enhance regenerative performance in humans.
authors: Division of Developmental Biology, Department of Cell and Molecular Biology Tulane University New Orleans Louisiana 70118 USA.
authors: Jennifer
authors: J
authors: Simkin
authors: Division of Developmental Biology, Department of Cell and Molecular Biology Tulane University New Orleans Louisiana 70118 USA.
authors: Mimi C
authors: MC
authors: Sammarco
authors: Division of Developmental Biology, Department of Cell and Molecular Biology Tulane University New Orleans Louisiana 70118 USA.
authors: Lindsay A
authors: LA
authors: Dawson
authors: Division of Developmental Biology, Department of Cell and Molecular Biology Tulane University New Orleans Louisiana 70118 USA.
authors: Paula P
authors: PP
authors: Schanes
authors: Division of Developmental Biology, Department of Cell and Molecular Biology Tulane University New Orleans Louisiana 70118 USA.
authors: Ling
authors: L
authors: Yu
authors: Division of Developmental Biology, Department of Cell and Molecular Biology Tulane University New Orleans Louisiana 70118 USA.
authors: Ken
authors: K
authors: Muneoka
keywords: Blastema; digit; hypoxia; mouse; regeneration; stem cells; wound healing