title: Bcl-2 family proteins: master regulators of cell survival.
abstract: The most prominent function of proteins of the Bcl-2 family is regulation of the initiation of intrinsic (mitochondrial) pathways of apoptosis. However, recent research has revealed that in addition to regulation of mitochondrial apoptosis, proteins of the Bcl-2 family play important roles in regulating other cellular pathways with a strong impact on cell survival like autophagy, endoplasmic reticulum (ER) stress response, intracellular calcium dynamics, cell cycle progression, mitochondrial dynamics and energy metabolism. This review summarizes the recent knowledge about functions of Bcl-2 family proteins that are related to cell survival.
authors: Jozef
authors: J
authors: Hatok
authors: Peter
authors: P
authors: Racay
mesh_terms: D000818:Animals; D001343:Autophagy; D002118:Calcium / Q000378:metabolism; D002352:Carrier Proteins / Q000378:metabolism; D002453:Cell Cycle / Q000235:genetics; D002470:Cell Survival / Q000235:genetics*; D059865:Endoplasmic Reticulum Stress / Q000235:genetics; D004734:Energy Metabolism; D005786:Gene Expression Regulation; D006801:Humans; D008928:Mitochondria / Q000235:genetics / Q000378:metabolism; D063154:Mitochondrial Dynamics; D005810:Multigene Family; D011485:Protein Binding; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D002352:Carrier Proteins; D019253:Proto-Oncogene Proteins c-bcl-2; D002118:Calcium