title: A population-based study of large granular lymphocyte leukemia.
abstract: Large granular lymphocyte (LGL) leukemia is a lymphoproliferative disorder of cytotoxic cells. T-cell LGL (T-LGL) leukemia is characterized by accumulation of cytotoxic T cells in blood and infiltration of the bone marrow, liver or spleen. Population-based studies have not been reported in LGL leukemia. We present clinical characteristics, natural history and risk factors for poor survival in patients with LGL leukemia using the Surveillance, Epidemiology, and End Results Program (SEER) and the United States National Cancer Data Base (NCDB). LGL leukemia is an extremely rare disease with the incidence of 0.2 cases per 1 000 000 individuals. The median age at diagnosis was 66.5 years with females likely to be diagnosed at 3 years earlier compared with males. Analysis of patient-level data using NCDB (n=978) showed that 45% patients with T-LGL leukemia required some form of systemic treatment at the time of diagnosis. T-LGL leukemia patients have reduced survival compared with general population, with a median overall survival of 9 years. Multivariate analysis showed that age >60 years at the time of diagnosis and the presence of significant comorbidities were independent predictors of poor survival.
authors: Division of Hematology, Mayo clinic, Rochester, MN, USA.
authors: M V
authors: MV
authors: Shah
authors: Division of Hematology, Mayo clinic, Rochester, MN, USA.
authors: C C
authors: CC
authors: Hook
authors: Division of Hematology, Mayo clinic, Rochester, MN, USA.
authors: T G
authors: TG
authors: Call
authors: Division of Hematology, Mayo clinic, Rochester, MN, USA.|Robert D. and Patricia E. Kern Center for the Science of Health Care Delivery, Mayo Clinic, Rochester, MN, USA.
authors: R S
authors: RS
authors: Go
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D015994:Incidence; D054066:Leukemia, Large Granular Lymphocytic / Q000175:diagnosis / Q000453:epidemiology* / Q000401:mortality / Q000628:therapy; D008297:Male; D008875:Middle Aged; D011159:Population Surveillance; D018426:SEER Program; D016019:Survival Analysis; D014481:United States