title: Quantitative determination of activation energies in mechanochemical reactions.
abstract: Mechanochemical reactions often result in 100% yields of single products, making purifying procedures obsolete. Mechanochemistry is also a sustainable and eco-friendly method. The ever increasing interest in this method is contrasted by a lack in mechanistic understanding of the mechanochemical reactivity and selectivity. Recent in situ investigations provided direct insight into formation pathways. However, the currently available theories do not predict temperature T as an influential factor. Here, we report the first determination of an apparent activation energy for a mechanochemical reaction. In a temperature-dependent in situ study the cocrystallisation of ibuprofen and nicotinamide was investigated as a model system. These experiments provide a pivotal step towards a comprehensive understanding of milling reaction mechanisms.
authors: BAM Federal Institute for Materials Research and Testing, R.-Willstätter-Str. 11, 12489 Berlin, Germany. franziska.emmerling@bam.de and Humboldt-Universität zu Berlin, B.-Taylor-Str. 2, 12489 Berlin, Germany.
authors: Franziska
authors: F
authors: Fischer
authors: BAM Federal Institute for Materials Research and Testing, R.-Willstätter-Str. 11, 12489 Berlin, Germany. franziska.emmerling@bam.de.
authors: Klaus-Jürgen
authors: KJ
authors: Wenzel
authors: BAM Federal Institute for Materials Research and Testing, R.-Willstätter-Str. 11, 12489 Berlin, Germany. franziska.emmerling@bam.de and Humboldt-Universität zu Berlin, B.-Taylor-Str. 2, 12489 Berlin, Germany.
authors: Klaus
authors: K
authors: Rademann
authors: BAM Federal Institute for Materials Research and Testing, R.-Willstätter-Str. 11, 12489 Berlin, Germany. franziska.emmerling@bam.de.
authors: Franziska
authors: F
authors: Emmerling