title: Dapsone-induced pure red cell aplasia and cholestatic jaundice: A new experience for diagnosis and management.
abstract: Dapsone (4,4'- diaminodiphenylsulfone) is the parent compound of the sulfones, and it has potent antiparasitic, anti-inflammatory, and immunomodulatory effects. It is used in the treatment of leprosy, dermatitis herpetiformis, and prophylactically to prevent Pneumocystis pneumonia and toxoplasmosis in patients unable to tolerate trimethoprim with sulfamethoxazole. We hereby report a case of dapsone toxicity who developed pure red cell aplasia and cholestatic jaundice in a suspected case of dermatitis herpetiformis. Patient had an excellent response to corticosteroids after withdrawal of dapsone.
authors: Department of Medicine, King George Medical University, Lucknow, Uttar Pradesh, India.
authors: Kamal Kumar
authors: KK
authors: Sawlani
authors: Department of Medicine, King George Medical University, Lucknow, Uttar Pradesh, India.
authors: Shyam Chand
authors: SC
authors: Chaudhary
authors: Department of Medicine, King George Medical University, Lucknow, Uttar Pradesh, India.
authors: Jitendra
authors: J
authors: Singh
authors: Department of Medicine, King George Medical University, Lucknow, Uttar Pradesh, India.
authors: Deep Chandh
authors: DC
authors: Raja
authors: Department of Clinical Hematology and Oncology, King George Medical University, Lucknow, Uttar Pradesh, India.
authors: Sanjay
authors: S
authors: Mishra
authors: Department of Pathology, King George Medical University, Lucknow, Uttar Pradesh, India.
authors: Madhu Mati
authors: MM
authors: Goel
keywords: Cholestatic jaundice; Dapsone; dermatitis herpetiformis; pure red cell aplasia