title: Polylactides in additive biomanufacturing.
abstract: New advanced manufacturing technologies under the alias of additive biomanufacturing allow the design and fabrication of a range of products from pre-operative models, cutting guides and medical devices to scaffolds. The process of printing in 3 dimensions of cells, extracellular matrix (ECM) and biomaterials (bioinks, powders, etc.) to generate in vitro and/or in vivo tissue analogue structures has been termed bioprinting. To further advance in additive biomanufacturing, there are many aspects that we can learn from the wider additive manufacturing (AM) industry, which have progressed tremendously since its introduction into the manufacturing sector. First, this review gives an overview of additive manufacturing and both industry and academia efforts in addressing specific challenges in the AM technologies to drive toward AM-enabled industrial revolution. After which, considerations of poly(lactides) as a biomaterial in additive biomanufacturing are discussed. Challenges in wider additive biomanufacturing field are discussed in terms of (a) biomaterials; (b) computer-aided design, engineering and manufacturing; (c) AM and additive biomanufacturing printers hardware; and (d) system integration. Finally, the outlook for additive biomanufacturing was discussed.
authors: Department of Experimental Trauma Surgery, Klinikum Rechts der Isar, Technical University of Munich, Munich, Germany. Electronic address: patrina.poh@tum.de.
authors: Patrina S P
authors: PSP
authors: Poh
authors: Institute of Health and Biomedical Innovation, Queensland University of Technology (QUT), Brisbane, Australia. Electronic address: m.chhaya@qut.edu.au.
authors: Mohit P
authors: MP
authors: Chhaya
authors: Institute of Health and Biomedical Innovation, Queensland University of Technology (QUT), Brisbane, Australia. Electronic address: felix.wunner@hdr.qut.edu.au.
authors: Felix M
authors: FM
authors: Wunner
authors: Institute of Health and Biomedical Innovation, Queensland University of Technology (QUT), Brisbane, Australia. Electronic address: elena.juanpardo@qut.edu.au.
authors: Elena M
authors: EM
authors: De-Juan-Pardo
authors: Department of Plastic Surgery and Hand Surgery, Klinikum Rechts der Isar, Technical University of Munich, Munich, Germany; Clinic for Trauma Surgery, Orthopaedic Surgery and Plastic Surgery, University Medical Center Göttingen, Göttingen, Germany. Electronic address: arndt.schilling@med.uni-goettingen.de.
authors: Arndt F
authors: AF
authors: Schilling
authors: Department of Plastic Surgery and Hand Surgery, Klinikum Rechts der Isar, Technical University of Munich, Munich, Germany. Electronic address: jan-thorsten.schantz@tum.de.
authors: Jan-Thorsten
authors: JT
authors: Schantz
authors: Department of Experimental Trauma Surgery, Klinikum Rechts der Isar, Technical University of Munich, Munich, Germany. Electronic address: martijn.vangriensven@tum.de.
authors: Martijn
authors: M
authors: van Griensven
authors: Institute of Health and Biomedical Innovation, Queensland University of Technology (QUT), Brisbane, Australia; Institute for Advanced Study, Technical University of Munich, Garching, Germany. Electronic address: dietmar.hutmacher@qut.edu.au.
authors: Dietmar W
authors: DW
authors: Hutmacher
mesh_terms: D001672:Biocompatible Materials / Q000138:chemical synthesis* / Q000737:chemistry; D062028:Bioprinting / Q000295:instrumentation / Q000379:methods*; D017076:Computer-Aided Design; D008420:Manufactured Materials; D011091:Polyesters / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D001672:Biocompatible Materials; D011091:Polyesters; C033616:poly(lactide)
keywords: 3D printing; Additive manufacturing; Bioprinting; Computer-aided design; Computer-aided engineering; Computer-aided manufacturing; Poly(lactic acids); Tissue engineering and regenerative medicine