title: Functional and structural brain connectivity of young binge drinkers: a follow-up study.
abstract: Adolescence is a period of ongoing brain maturation characterized by hierarchical changes in the functional and structural networks. For this reason, the young brain is particularly vulnerable to the toxic effects of alcohol. Nowadays, binge drinking is a pattern of alcohol consumption increasingly prevalent among adolescents. The aim of the present study is to evaluate the evolution of the functional and anatomical connectivity of the Default Mode Network (DMN) in young binge drinkers along two years. Magnetoencephalography signal during eyes closed resting state as well as Diffusion Tensor Imaging (DTI) were acquired twice within a 2-year interval from 39 undergraduate students (22 controls, 17 binge drinkers) with neither personal nor family history of alcoholism. The group comparison showed that, after maintaining a binge drinking pattern along at least two years, binge drinkers displayed an increased brain connectivity of the DMN in comparison with the control group. On the other hand, the structural connectivity did not show significant differences neither between groups nor over the time. These findings point out that a continued pattern of binge drinking leads to functional alterations in the normal brain maturation process, even before anatomical changes can be detected.
authors: Laboratory of Cognitive and Computational Neuroscience, Centre of Biomedical Technology (CTB), 28223, Madrid, Spain.
authors: A
authors: A
authors: Correas
authors: Laboratory of Cognitive and Computational Neuroscience, Centre of Biomedical Technology (CTB), 28223, Madrid, Spain.
authors: P
authors: P
authors: Cuesta
authors: Neuropsychophysiology Lab, Research Center on Psychology (CIPsi), School of Psychology, 4710, University of Minho, Braga, Portugal.
authors: E
authors: E
authors: López-Caneda
authors: Department of Clinical Psychology and Psychobiology, University of Santiago de Compostela, 15782, Santiago de Compostela, Spain.
authors: S
authors: S
authors: Rodríguez Holguín
authors: Department of Psychobiology, Complutense University Madrid, 28040, Madrid, Spain.
authors: L M
authors: LM
authors: García-Moreno
authors: Laboratory of Cognitive and Computational Neuroscience, Centre of Biomedical Technology (CTB), 28223, Madrid, Spain.
authors: J A
authors: JA
authors: Pineda-Pardo
authors: Department of Clinical Psychology and Psychobiology, University of Santiago de Compostela, 15782, Santiago de Compostela, Spain.
authors: F
authors: F
authors: Cadaveira
authors: Laboratory of Cognitive and Computational Neuroscience, Centre of Biomedical Technology (CTB), 28223, Madrid, Spain.
authors: F
authors: F
authors: Maestú
mesh_terms: D000293:Adolescent; D000428:Alcohol Drinking; D063425:Binge Drinking / Q000503:physiopathology*; D001921:Brain / Q000502:physiology / Q000503:physiopathology*; D001931:Brain Mapping; D016022:Case-Control Studies; D056324:Diffusion Tensor Imaging; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015225:Magnetoencephalography; D008297:Male; D009434:Neural Pathways / Q000187:drug effects; D055815:Young Adult