title: C23 promotes tumorigenesis via suppressing p53 activity.
abstract: C23 is an abundant and multi-functional protein, which plays an important role in various biological processes, including ribosome biogenesis and maturation, cell cycle checkpoints and transcriptional regulation [1, 2]. However, the role of C23 in controlling tumorigenesis has not been well defined. Here we report that C23 is highly expressed in cancer cells and the elevated expression of C23 facilitates cancer cell proliferation in vitro and tumor xenograft growth in vivo. Notably, C23 binds to p53 through its GAR domain and suppresses the transcriptional activity of p53 under DNA damage and hypoxia. Moreover, the GAR domain is critical for C23-mediated tumor cell proliferation both in vitro and in vivo. Our findings reveal a novel role of C23 in tumorigenesis and suggest that C23 may represent a potential therapeutic target for treating malignancy.
authors: Department of Immunology, Anhui Medical University, Hefei, China.
authors: Qun
authors: Q
authors: Li
authors: Department of Anesthesiology, The First Affiliated Hospital of Anhui Medical University, Hefei, China.
authors: Yan
authors: Y
authors: Zhu
authors: Department of Clinical Nutriology, The First Affiliated Hospital of Anhui Medical University, Hefei, China.
authors: Lili
authors: L
authors: Hou
authors: Department of Molecular Biology, Shanxi Cancer Hospital and Institute, Affiliated Hospital of Shanxi Medical University, Taiyuan, China.
authors: Juan
authors: J
authors: Wang
authors: School of Life Sciences, Anhui Medical University, Hefei, China.
authors: Guilin
authors: G
authors: Hu
authors: School of Pharmacy, Anhui Medical University, Hefei, China.
authors: Xing
authors: X
authors: Fang
authors: School of Pharmacy, Anhui Medical University, Hefei, China.
authors: Yamin
authors: Y
authors: Hu
authors: School of Pharmacy, Anhui Medical University, Hefei, China.
authors: Tingting
authors: T
authors: Tao
authors: School of Pharmacy, Anhui Medical University, Hefei, China.
authors: Xin
authors: X
authors: Wei
authors: School of Pharmacy, Anhui Medical University, Hefei, China.
authors: Haitao
authors: H
authors: Tang
authors: Department of Immunology, Anhui Medical University, Hefei, China.
authors: Baojun
authors: B
authors: Huang
authors: Department of Immunology, Anhui Medical University, Hefei, China.
authors: Wanglai
authors: W
authors: Hu
mesh_terms: D000818:Animals; D017209:Apoptosis; D063646:Carcinogenesis; D045744:Cell Line, Tumor; D049109:Cell Proliferation; D002471:Cell Transformation, Neoplastic / Q000235:genetics; D004249:DNA Damage; D015972:Gene Expression Regulation, Neoplastic; D045325:HCT116 Cells; D006367:HeLa Cells; D056945:Hep G2 Cells; D006801:Humans; D000860:Hypoxia; D061986:MCF-7 Cells; D051379:Mice; D008819:Mice, Nude; D009368:Neoplasm Transplantation; D010750:Phosphoproteins / Q000378:metabolism*; D000072417:Protein Domains; D016601:RNA-Binding Proteins / Q000378:metabolism*; D015398:Signal Transduction; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism*; D000097796:Nucleolin
chemical_list: D010750:Phosphoproteins; D016601:RNA-Binding Proteins; D016159:Tumor Suppressor Protein p53; D000097796:Nucleolin; C495901:TP53 protein, human
keywords: C23; p53; tumorigenesis