title: An annulative transfer hydrogenation strategy enables straightforward access to tetrahydro fused-pyrazine derivatives.
abstract: A ruthenium-catalysed annulative transfer hydrogenation strategy, enabling straightforward access to tetrahydro fused-pyrazine derivatives from N-heteroaryl diamines and vicinal diols, has been demonstrated for the first time. Such a synthesis proceeds with unprecedented synthetic effectiveness including high step- and atom efficiency, generation of water as the sole by-product, short reaction time and no need for external high pressure H2 gas, offering an important basis for the transformation of vicinal diols, a class of bio-mass derived resources, into functionalized products.
authors: Key Laboratory of Functional Molecular Engineering of Guangdong Province, School of Chemistry & Chemical Engineering and State Key Laboratory of Pulp and Paper Engineering, South China University of Technology, Wushan Rd-381, Guangzhou 510641, People's Republic of China.
authors: Biao
authors: B
authors: Xiong
authors: Key Laboratory of Functional Molecular Engineering of Guangdong Province, School of Chemistry & Chemical Engineering and State Key Laboratory of Pulp and Paper Engineering, South China University of Technology, Wushan Rd-381, Guangzhou 510641, People's Republic of China.
authors: Shu-Di
authors: SD
authors: Zhang
authors: School of Chemical & Environmental Engineering, Wuyi University, Jiangmen 529020, Guangdong Province, P. R. China.
authors: Lu
authors: L
authors: Chen
authors: School of Chemical & Environmental Engineering, Wuyi University, Jiangmen 529020, Guangdong Province, P. R. China.
authors: Bin
authors: B
authors: Li
authors: Key Laboratory of Functional Molecular Engineering of Guangdong Province, School of Chemistry & Chemical Engineering and State Key Laboratory of Pulp and Paper Engineering, South China University of Technology, Wushan Rd-381, Guangzhou 510641, People's Republic of China.
authors: Huan-Feng
authors: HF
authors: Jiang
authors: Key Laboratory of Functional Molecular Engineering of Guangdong Province, School of Chemistry & Chemical Engineering and State Key Laboratory of Pulp and Paper Engineering, South China University of Technology, Wushan Rd-381, Guangzhou 510641, People's Republic of China.
authors: Min
authors: M
authors: Zhang