title: Leukocyte adhesion molecule dynamics after Natalizumab withdrawal in Multiple Sclerosis.
abstract: Cell-adhesion molecules (CAMs) dynamics in Multiple Sclerosis (MS) patients have been widely studied after Natalizumab (NTZ) introduction. However, their temporal dynamics after NTZ withdrawal (NTZ-W) has not been described. We prospectively evaluate changes in the expression levels of CAMs (CD49d, CD29, L-Selectin and CD11a) involved in T cell migration of 22 MS patients after NTZ-W. CD49d, CD29 and CD11a expression experienced a continuous increase expression two months after NTZ-W and Cd49d expression at month six after NTZ-W correlated to NTZ treatment duration, both in CD45+CD4+and CD45+CD8+. CD49d expression up to month three after NTZ-W was related to MS activity in CD45+CD8+at the end of the study. Results from this study suggest that patients with a longer NTZ treatment are more susceptible to present a "molecular rebound" after NTZ-W. CD49d determination may be a useful tool to closely monitor MS activity in patients who interrupt NTZ.
authors: Multiple Sclerosis Unit, Bellvitge University Hospital - IDIBELL, L'Hospitalet de LLobregat, Barcelona, Spain; Department of Neurology, Hospital del Mar Medical Research Institute (IMIM), Barcelona, Spain. Electronic address: cobocalvo.alvaro@sfr.fr.
authors: Álvaro
authors: Á
authors: Cobo-Calvo
authors: Laboratori de Recerca Translacional ICO-IDIBELL, Laboratorio de investigación ICO-IDIBELL, L'Hospitalet de LLobregat, Barcelona, Spain.
authors: Agnes
authors: A
authors: Figueras
authors: Multiple Sclerosis Unit, Bellvitge University Hospital - IDIBELL, L'Hospitalet de LLobregat, Barcelona, Spain.
authors: Laura
authors: L
authors: Bau
authors: Multiple Sclerosis Unit, Bellvitge University Hospital - IDIBELL, L'Hospitalet de LLobregat, Barcelona, Spain.
authors: Elisabet
authors: E
authors: Matas
authors: Multiple Sclerosis Unit, Bellvitge University Hospital - IDIBELL, L'Hospitalet de LLobregat, Barcelona, Spain; Department of Neurology, Joan XXIII University Hospital, Universitat Rovira I Virgili, Tarragona, Spain.
authors: María Alba
authors: MA
authors: Mañé Martínez
authors: Multiple Sclerosis Unit, Bellvitge University Hospital - IDIBELL, L'Hospitalet de LLobregat, Barcelona, Spain.
authors: Isabel
authors: I
authors: León
authors: Institut de Diagnòstic per la Imatge, IDI, Hospital Duran i Reynals, L'Hospitalet de Llobregat, Barcelona, Spain.
authors: Carles
authors: C
authors: Majòs
authors: Multiple Sclerosis Unit, Bellvitge University Hospital - IDIBELL, L'Hospitalet de LLobregat, Barcelona, Spain.
authors: Lucia
authors: L
authors: Romero-Pinel
authors: Multiple Sclerosis Unit, Bellvitge University Hospital - IDIBELL, L'Hospitalet de LLobregat, Barcelona, Spain.
authors: Sergio
authors: S
authors: Martínez-Yélamos
mesh_terms: D000328:Adult; D015703:Antigens, CD / Q000276:immunology*; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology; D015815:Cell Adhesion Molecules / Q000276:immunology*; D005260:Female; D006801:Humans; D007155:Immunologic Factors / Q000494:pharmacology / Q000627:therapeutic use*; D039041:Integrin alpha4beta1 / Q000276:immunology; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000188:drug therapy* / Q000276:immunology; D000069442:Natalizumab / Q000494:pharmacology / Q000627:therapeutic use*; D055815:Young Adult
chemical_list: D015703:Antigens, CD; D015815:Cell Adhesion Molecules; D007155:Immunologic Factors; D039041:Integrin alpha4beta1; D000069442:Natalizumab
keywords: Adhesion molecules; Dynamics; Multiple Sclerosis; Natalizumab withdrawal; VLA-4