title: Rivaroxaban in treatment refractory heparin-induced thrombocytopenia.
abstract: Following orthopaedic surgery, a 56-year-old woman developed heparin-induced thrombocytopenia (HIT), complicated by extensive proximal deep vein thrombosis. The patient did not respond to multiple conventional therapies; however, a prompt treatment response occurred after starting rivaroxaban at standard dosing. This case represents the first documentation of efficacy for rivaroxaban in the setting of treatment refractory HIT and strengthens the limited existing evidence for this agent in HIT.
authors: Department of Haematology, Monash Health, Clayton, Victoria, Australia.
authors: Joshua Misha Lewis
authors: JM
authors: Casan
authors: Department of Haematology, Monash Health, Clayton, Victoria, Australia.
authors: George
authors: G
authors: Grigoriadis
authors: Department of Haematology, Monash Health, Clayton, Victoria, Australia.
authors: Noel
authors: N
authors: Chan
authors: Department of Haematology, Monash Health, Clayton, Victoria, Australia.
authors: Sanjeev
authors: S
authors: Chunilal
mesh_terms: D000925:Anticoagulants / Q000009:adverse effects; D004351:Drug Resistance; D065427:Factor Xa Inhibitors / Q000627:therapeutic use*; D005260:Female; D006493:Heparin / Q000009:adverse effects; D006801:Humans; D008875:Middle Aged; D019637:Orthopedic Procedures / Q000009:adverse effects; D011183:Postoperative Complications / Q000139:chemically induced / Q000188:drug therapy; D000069552:Rivaroxaban / Q000627:therapeutic use*; D013921:Thrombocytopenia / Q000139:chemically induced / Q000188:drug therapy*; D020246:Venous Thrombosis / Q000139:chemically induced / Q000188:drug therapy
chemical_list: D000925:Anticoagulants; D065427:Factor Xa Inhibitors; D006493:Heparin; D000069552:Rivaroxaban