title: A new quinolinone from freshwater lake-derived fungus Myrothecium verrucaria.
abstract: One new quinolinone, 7-hydroxy-3-methoxyviridicatin (1), along with eight known compounds (2-9) was isolated from the fungus Myrothecium verrucaria, which was collected from lake water of Chenghai, Yunnan Province, China. Their structures were elucidated by detailed analysis of spectroscopic data and comparison with related known compounds. Compounds 1 and 2 exhibited weak antibacterial activity. To the best of our knowledge, this is the first report on quinolinones (1-4) as the secondary metabolites of M. verrucaria.
authors: a School of Pharmaceutical Sciences, Chinese Center for Chirality , Hebei University , Baoding , China.
authors: Can-Can
authors: CC
authors: Zhang
authors: a School of Pharmaceutical Sciences, Chinese Center for Chirality , Hebei University , Baoding , China.
authors: Shuang-Shuang
authors: SS
authors: Ding
authors: a School of Pharmaceutical Sciences, Chinese Center for Chirality , Hebei University , Baoding , China.
authors: Wen-Si
authors: WS
authors: Shi
authors: a School of Pharmaceutical Sciences, Chinese Center for Chirality , Hebei University , Baoding , China.
authors: Fei
authors: F
authors: Cao
authors: a School of Pharmaceutical Sciences, Chinese Center for Chirality , Hebei University , Baoding , China.
authors: Hua-Jie
authors: HJ
authors: Zhu
authors: b Key Laboratory of Medicinal Chemistry for Natural Resources, Ministry of Education , Yunnan University , Kunming , China.
authors: Meng-Liang
authors: ML
authors: Wen
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D002681:China; D005618:Fresh Water / Q000382:microbiology; D006999:Hypocreales / Q000737:chemistry*; D060106:Lakes / Q000382:microbiology; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D011804:Quinolines / Q000737:chemistry* / Q000494:pharmacology; D015363:Quinolones; D021241:Spectrometry, Mass, Electrospray Ionization; D014871:Water Microbiology
chemical_list: C000618257:7-hydroxy-3-methoxyviridicatin; D000900:Anti-Bacterial Agents; D011804:Quinolines; D015363:Quinolones
keywords: Myrothecium verrucaria; antibacterial activity; benzodiazepine; quinolinone