title: The effects of fast-track surgery on inflammation and immunity in patients undergoing colorectal surgery.
abstract: OBJECTIVE
  The objective of this study is to explore the effects of the fast-track surgery (FTS) program on inflammation and immunity in patients undergoing colorectal surgery.
  
  
  METHODS
  From August 2014 to March 2015, a prospective and randomized controlled trial of 230 patients who underwent colorectal surgery was performed. The patients were randomly assigned to an FTS group (116 patients) or a traditional group (114 patients). Inflammatory mediators, immunological indicators, postoperative recovery indexes, and complications were compared between the two groups.
  
  
  RESULTS
  The inflammatory mediators (CRP, IL-6, TNF-α) were lower in the FTS group than in the traditional group (P < 0.05) on postoperative day (POD) 1, POD 4, and POD 6, and the immunological indicators (IgG, IgA, C3, C4) of the FTS group were superior to those of the traditional group (P < 0.05) on POD 4 and POD 6. The time to first aerofluxus, defecation, oral intake, and ambulation after surgery was shorter in the FTS group than in the traditional group (P < 0.05); however, the duration of postoperative hospitalization did not differ significantly between the two groups (P > 0.05). The total complications were significantly lower in the FTS group than in the traditional group (P < 0.05).
  
  
  CONCLUSIONS
  The FTS program can decrease inflammation, maintain immune homeostasis, and improve rehabilitation effects in colorectal surgery patients.
authors: Department of Biliary Surgery, West China Hospital of Sichuan University, Chengdu, 610041, China.
authors: Jinhua
authors: J
authors: Feng
authors: Nursing Department, West China Hospital of Sichuan University, Chengdu, 610041, China. likalika127127@163.com.
authors: Ka
authors: K
authors: Li
authors: Department of Gastrointestinal Surgery, West China Hospital of Sichuan University, Chengdu, 610041, China.
authors: Li
authors: L
authors: Li
authors: Department of Gastrointestinal Surgery, West China Hospital of Sichuan University, Chengdu, 610041, China.
authors: Xiaodong
authors: X
authors: Wang
authors: Nursing Department, West China Hospital of Sichuan University, Chengdu, 610041, China.
authors: Mingjun
authors: M
authors: Huang
authors: Department of Gastrointestinal Surgery, West China Hospital of Sichuan University, Chengdu, 610041, China.
authors: Jie
authors: J
authors: Yang
authors: West China School of Nursing, Sichuan University, Chengdu, 610041, China.
authors: Yanjie
authors: Y
authors: Hu
mesh_terms: D003107:Colorectal Surgery / Q000009:adverse effects* / Q000534:rehabilitation; D005260:Female; D006801:Humans; D007109:Immunity; D007249:Inflammation / Q000209:etiology*; D018836:Inflammation Mediators / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000209:etiology; D011184:Postoperative Period
chemical_list: D018836:Inflammation Mediators
keywords: Colorectal cancer; Fast-track surgery; Immunity; Inflammation; Rehabilitation effects