title: Timing of cranial vault remodeling in nonsyndromic craniosynostosis: a single-institution 30-year experience.
abstract: OBJECTIVE Due to the changing properties of the infant skull, there is still no clear consensus on the ideal time to surgically intervene in cases of nonsyndromic craniosynostosis (NSC). This study aims to shed light on how patient age at the time of surgery may affect surgical outcomes and the subsequent need for reoperation. METHODS A retrospective cohort review was conducted for patients with NSC who underwent primary cranial vault remodeling between 1990 and 2013. Patients' demographic and clinical characteristics and surgical interventions were recorded. Postoperative outcomes were assessed by assigning each procedure to a Whitaker category. Multivariate logistic regression analysis was performed to determine the relationship between age at surgery and need for minor (Whitaker I or II) versus major (Whitaker III or IV) reoperation. Odds ratios (ORs) for Whitaker category by age at surgery were assigned. RESULTS A total of 413 unique patients underwent cranial vault remodeling procedures for NSC during the study period. Multivariate logistic regression demonstrated increased odds of requiring major surgical revisions (Whitaker III or IV) in patients younger than 6 months of age (OR 2.49, 95% CI 1.05-5.93), and increased odds of requiring minimal surgical revisions (Whitaker I or II) in patients older than 6 months of age (OR 2.72, 95% CI 1.16-6.41). CONCLUSIONS Timing, as a proxy for the changing properties of the infant skull, is an important factor to consider when planning vault reconstruction in NSC. The data presented in this study demonstrate that patients operated on before 6 months of age had increased odds of requiring major surgical revisions.
authors: Departments of 1 Plastic and Reconstructive Surgery and.
authors: Alan F
authors: AF
authors: Utria
authors: Departments of 1 Plastic and Reconstructive Surgery and.
authors: Joseph
authors: J
authors: Lopez
authors: Departments of 1 Plastic and Reconstructive Surgery and.
authors: Regina S
authors: RS
authors: Cho
authors: Departments of 1 Plastic and Reconstructive Surgery and.
authors: Gerhard S
authors: GS
authors: Mundinger
authors: Neurosurgery, Johns Hopkins Hospital; and.
authors: George I
authors: GI
authors: Jallo
authors: Neurosurgery, Johns Hopkins Hospital; and.
authors: Edward S
authors: ES
authors: Ahn
authors: Departments of 1 Plastic and Reconstructive Surgery and.|Division of Plastic Surgery, Mercy Medical Center, Baltimore, Maryland.
authors: Craig Vander
authors: CV
authors: Kolk
authors: Departments of 1 Plastic and Reconstructive Surgery and.
authors: Amir H
authors: AH
authors: Dorafshar
mesh_terms: D015331:Cohort Studies; D003393:Cranial Sutures / Q000473:pathology; D003398:Craniosynostoses / Q000175:diagnosis* / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D008297:Male; D019651:Plastic Surgery Procedures / Q000379:methods / Q000639:trends*; D012086:Reoperation / Q000379:methods / Q000639:trends*; D012189:Retrospective Studies; D013997:Time Factors
keywords: NSC = nonsyndromic craniosynostosis; OR = odds ratio; cranial vault remodeling; craniofacial surgery; craniosynostosis; nonsyndromic; sutures; synostosis