title: Regulatory non-coding RNA: new instruments in the orchestration of cell death.
abstract: Non-coding RNA (ncRNA) comprises a substantial portion of primary transcripts that are generated by genomic transcription, but are not translated into protein. The possible functions of these once considered 'junk' molecules have incited considerable interest and new insights have emerged. The two major members of ncRNAs, namely micro RNA (miRNA) and long non-coding RNA (lncRNA), have important regulatory roles in gene expression and many important physiological processes, which has recently been extended to programmed cell death. The previous paradigm of programmed cell death only by apoptosis has recently expanded to include modalities of regulated necrosis (RN), and particularly necroptosis. However, most research efforts in this field have been on protein regulators, leaving the role of ncRNAs largely unexplored. In this review, we discuss important findings concerning miRNAs and lncRNAs that modulate apoptosis and RN pathways, as well as the miRNA-lncRNA interactions that affect cell death regulation.
authors: Matthew Mailing Centre for Translational Transplantation Studies, Lawson Health Research Institute, London Health Sciences Centre, University of Western Ontario, London, Ontario, Canada.|Department of Medicine, University of Western Ontario, London, Ontario, Canada.|Department of Pathology, University of Western Ontario, London, Ontario, Canada.
authors: Ye
authors: Y
authors: Su
authors: Key Laboratory of Kidney Diseases, Department of Pathology, Hebei Medical University, Shijiazhuang, China.
authors: Haijiang
authors: H
authors: Wu
authors: Matthew Mailing Centre for Translational Transplantation Studies, Lawson Health Research Institute, London Health Sciences Centre, University of Western Ontario, London, Ontario, Canada.|Department of Pathology, University of Western Ontario, London, Ontario, Canada.
authors: Alexander
authors: A
authors: Pavlosky
authors: Department of Oncology, Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, China.
authors: Ling-Lin
authors: LL
authors: Zou
authors: Department of Oncology and Immunotherapy, Hebei General Hospital, Shijiazhuang, China.
authors: Xinna
authors: X
authors: Deng
authors: Matthew Mailing Centre for Translational Transplantation Studies, Lawson Health Research Institute, London Health Sciences Centre, University of Western Ontario, London, Ontario, Canada.|Department of Medicine, University of Western Ontario, London, Ontario, Canada.|Department of Pathology, University of Western Ontario, London, Ontario, Canada.
authors: Zhu-Xu
authors: ZX
authors: Zhang
authors: Matthew Mailing Centre for Translational Transplantation Studies, Lawson Health Research Institute, London Health Sciences Centre, University of Western Ontario, London, Ontario, Canada.|Department of Medicine, University of Western Ontario, London, Ontario, Canada.|Department of Pathology, University of Western Ontario, London, Ontario, Canada.
authors: Anthony M
authors: AM
authors: Jevnikar
mesh_terms: D000818:Animals; D016923:Cell Death; D006801:Humans; D035683:MicroRNAs / Q000378:metabolism; D008954:Models, Biological; D022661:RNA, Untranslated / Q000235:genetics / Q000378:metabolism*
chemical_list: D035683:MicroRNAs; D022661:RNA, Untranslated