title: Effects of naloxone and yohimbine in polycystic ovary syndrome: a rabbit model study.
abstract: OBJECTIVE
  To assess the therapeutic effects of naloxone and yohimbine on polycystic ovary syndrome (PCOS) in a rabbit model in terms of body weight and endocrinological parameters (luteinizing hormone, insulin, and estradiol).
  
  
  METHODS
  A total of 50 adult, reproductively mature female rabbits (Oryctolagus cuniculus) were divided into five groups (n = 10/group). In the control group PCOS was not induced (negative control group), whereas in the remaining four groups (n = 40) PCOS was induced with a single i.m. injection of testosterone daily and were designated as follows: positive control, naloxone-treated (NalT), yohimbine-treated (YohT), and naloxone+yohimbine-treated (NalYT) groups.
  
  
  RESULTS
  A steadily ascending trend was noted in all of the studied parameters in the PCOS-induced group as compared to the negative control group. All the parameters showed a descending trend in the NalT group as compared to the positive control. Regarding the YohT and NalYT groups, all parameters showed a descending trend as compared to the positive control group except for estradiol.
  
  
  CONCLUSIONS
  Naloxone therapy either alone or combined with yohimbine improves a wide range of the clinical manifestations of PCOS. Furthermore, we suggest this therapy as an alternative to the conventional therapy with insulin-lowering agents in vogue.
authors: Lahore College for Women University, Lahore, Pakistan.
authors: Sumera
authors: S
authors: Sajjad
authors: Lahore College for Women University, Lahore, Pakistan.
authors: Sadia
authors: S
authors: Tobassum
authors: University College of Veterinary and Animal Sciences, The Islamia University of Bahawalpur, Pakistan.
authors: Umer
authors: U
authors: Farooq
authors: Lahore College for Women University, Lahore, Pakistan.
authors: Husna
authors: H
authors: Malik
authors: University College of Veterinary and Animal Sciences, The Islamia University of Bahawalpur, Pakistan.
authors: Musadiq
authors: M
authors: İdris
mesh_terms: D000818:Animals; D015992:Body Mass Index; D005260:Female; D005640:Follicle Stimulating Hormone; D007328:Insulin; D007333:Insulin Resistance; D007986:Luteinizing Hormone; D009270:Naloxone; D011085:Polycystic Ovary Syndrome; D011817:Rabbits; D013739:Testosterone; D015016:Yohimbine
chemical_list: D007328:Insulin; D015016:Yohimbine; D009270:Naloxone; D013739:Testosterone; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone
keywords: Polycystic ovary syndrome; naloxone; yohimbine