title: First International Consensus Conference on lesions of uncertain malignant potential in the breast (B3 lesions).
abstract: The purpose of this study is to obtain a consensus for the therapy of B3 lesions. The first International Consensus Conference on lesions of uncertain malignant potential in the breast (B3 lesions) including atypical ductal hyperplasia (ADH), flat epithelial atypia (FEA), classical lobular neoplasia (LN), papillary lesions (PL), benign phyllodes tumors (PT), and radial scars (RS) took place in January 2016 in Zurich, Switzerland organized by the International Breast Ultrasound School and the Swiss Minimally Invasive Breast Biopsy group-a subgroup of the Swiss Society of Senology. Consensus recommendations for the management and follow-up surveillance of these B3 lesions were developed and areas of research priorities were identified. The consensus recommendation for FEA, LN, PL, and RS diagnosed on core needle biopsy or vacuum-assisted biopsy (VAB) is to therapeutically excise the lesion seen on imaging by VAB and no longer by open surgery, with follow-up surveillance imaging for 5 years. The consensus recommendation for ADH and PT is, with some exceptions, therapeutic first-line open surgical excision. Minimally invasive management of selected B3 lesions with therapeutic VAB is acceptable as an alternative to first-line surgical excision.
authors: Brust-Zentrum Zürich, Seefeldstr. 214, 8008, Zurich, Switzerland. c.rageth@brust-zentrum.ch.|Centre du sein, Département de Gynécologie et d'Obstétrique, Hôpitaux Universitaires de Genève, Bd de la Cluse 30, 1211, Genève 14, Switzerland. c.rageth@brust-zentrum.ch.
authors: Christoph J
authors: CJ
authors: Rageth
authors: Institute of Cancer Research and Royal Marsden Hospital, London, UK.
authors: Elizabeth Am
authors: EA
authors: O'Flynn
authors: Memorial Sloan Kettering Cancer Center, Breast and Imaging Center, 300 E 66th St Suite 723, New York, NY, 10065, USA.
authors: Christopher
authors: C
authors: Comstock
authors: Institut für Radiologie und Nuklearmedizin, Luzerner Kantonsspital, 6000, Lucerne, Switzerland.
authors: Claudia
authors: C
authors: Kurtz
authors: Institute of Radiology, Department of Medical Services, Kantonsspital Baden, im Ergel, 5404, Baden, Switzerland.
authors: Rahel
authors: R
authors: Kubik
authors: DKD HELIOS Klinik, Aukammallee 33, 65191, Wiesbaden, Germany.
authors: Helmut
authors: H
authors: Madjar
authors: Imagerie du Flon, Vigie 5, 1000, Lausanne 20, Switzerland.
authors: Domenico
authors: D
authors: Lepori
authors: Centro di Radiologia e Senologia Luganese, Corso Pestalozzi 3, 6900, Lugano, Switzerland.
authors: Gert
authors: G
authors: Kampmann
authors: Marienhospital Osnabrück, Bischofsstraße 1, 49074, Osnabrück, Germany.
authors: Alexander
authors: A
authors: Mundinger
authors: Brust-Zentrum Zürich, Seefeldstr. 214, 8008, Zurich, Switzerland.
authors: Astrid
authors: A
authors: Baege
authors: Institut für Pathologie am Dietrich-Bonhoeffer-Klinikum, Salvador-Allende-Straße 30, 17036, Neubrandenburg, Germany.
authors: Thomas
authors: T
authors: Decker
authors: Brust-Zentrum Zürich, Seefeldstr. 214, 8008, Zurich, Switzerland.
authors: Stefanie
authors: S
authors: Hosch
authors: Brust-Zentrum Zürich, Seefeldstr. 214, 8008, Zurich, Switzerland.
authors: Christoph
authors: C
authors: Tausch
authors: Centre du sein, Centre Hospitalier, Universitaire Vaudois, 1011, Lausanne, Switzerland.
authors: Jean-François
authors: JF
authors: Delaloye
authors: Memorial Sloan Kettering Cancer Center, Breast and Imaging Center, 300 E 66th St Suite 723, New York, NY, 10065, USA.
authors: Elisabeth
authors: E
authors: Morris
authors: Institute of Surgical Pathology, University Hospital Zurich, Schmelzbergstrasse 12, 8091, Zurich, Switzerland.
authors: Zsuzsanna
authors: Z
authors: Varga
mesh_terms: D062005:Biopsy, Large-Core Needle; D001940:Breast / Q000473:pathology; D001943:Breast Neoplasms / Q000175:diagnosis*; D002285:Carcinoma, Intraductal, Noninfiltrating / Q000473:pathology*; D018275:Carcinoma, Lobular / Q000473:pathology*; D019468:Disease Management; D005260:Female; D006801:Humans; D061705:Image-Guided Biopsy; D008327:Mammography / Q000379:methods*; D003557:Phyllodes Tumor / Q000473:pathology*; D011159:Population Surveillance / Q000379:methods; D017410:Practice Guidelines as Topic
keywords: B3 lesions; Breast; Breast surgery; Consensus; Uncertain malignant potential; Vacuum-assisted biopsy