title: A comparative analysis reveals the dosage sensitivity and regulatory patterns of lncRNA in prostate cancer.
abstract: Although the key roles of long non-coding RNAs (lncRNAs) in multiple diseases are well documented, the relationship between the lncRNA copy number and expression is unknown. Here, we present a comprehensive study that demonstrates the impact of miRNA-TF co-regulatory motifs on the dosage effects of protein-coding genes (PCGs) and lncRNAs in prostate cancer. By integrating copy number profiles, expression profiles and regulatory relationships with miRNAs and transcription factors, we reveal that lncRNAs and PCGs correlate with distinct dosage sensitivity and regulatory pattern characteristics. We also show that lncRNAs from different genomic regions have different features. Using a custom-built framework, we identified 24 candidate prostate cancer-related lncRNAs based on the known properties of established prostate-related lncRNAs. Our method will enable the identification of cancer-related lncRNAs, which will provide new insights into cancer lncRNA biology.
authors: College of Bioinformatics Science and Technology, Harbin Medical University, Harbin 150081, China. xuyan@ems.hrbmu.edu.cn.
authors: Yongjing
authors: Y
authors: Liu
authors: Rui
authors: R
authors: Zhang
authors: Ning
authors: N
authors: Zhao
authors: Qiang
authors: Q
authors: Zhang
authors: Zichuang
authors: Z
authors: Yan
authors: Zhiqiang
authors: Z
authors: Chang
authors: Yunzhen
authors: Y
authors: Wei
authors: Cheng
authors: C
authors: Wu
authors: Jin
authors: J
authors: Xu
authors: Yan
authors: Y
authors: Xu
mesh_terms: D045744:Cell Line, Tumor; D030561:Databases, Nucleic Acid; D018628:Gene Dosage; D020869:Gene Expression Profiling; D015972:Gene Expression Regulation, Neoplastic; D053263:Gene Regulatory Networks; D006801:Humans; D008297:Male; D011471:Prostatic Neoplasms / Q000235:genetics* / Q000473:pathology; D020871:RNA Stability; D062085:RNA, Long Noncoding / Q000235:genetics*
chemical_list: D062085:RNA, Long Noncoding