title: Cerebrospinal Fluid Biomarkers of Alzheimer's Disease Correlate With Electroencephalography Parameters Assessed by Exact Low-Resolution Electromagnetic Tomography (eLORETA).
abstract: Recently, cerebrospinal fluid (CSF) biomarkers related to Alzheimer's disease (AD) have garnered a lot of clinical attention. To explore neurophysiological traits of AD and parameters for its clinical diagnosis, we examined the association between CSF biomarkers and electroencephalography (EEG) parameters in 14 probable AD patients. Using exact low-resolution electromagnetic tomography (eLORETA), artifact-free 40-sesond EEG data were estimated with current source density (CSD) and lagged phase synchronization (LPS) as the EEG parameters. Correlations between CSF biomarkers and the EEG parameters were assessed. Patients with AD showed significant negative correlation between CSF beta-amyloid (Aβ)-42 concentration and the logarithms of CSD over the right temporal area in the theta band. Total tau concentration was negatively correlated with the LPS between the left frontal eye field and the right auditory area in the alpha-2 band in patients with AD. Our study results suggest that AD biomarkers, in particular CSF Aβ42 and total tau concentrations are associated with the EEG parameters CSD and LPS, respectively. Our results could yield more insights into the complicated pathology of AD.
authors: 1 Department of Psychiatry, Osaka University Graduate School of Medicine, Osaka, Japan.
authors: Masahiro
authors: M
authors: Hata
authors: 1 Department of Psychiatry, Osaka University Graduate School of Medicine, Osaka, Japan.
authors: Toshihisa
authors: T
authors: Tanaka
authors: 1 Department of Psychiatry, Osaka University Graduate School of Medicine, Osaka, Japan.
authors: Hiroaki
authors: H
authors: Kazui
authors: 1 Department of Psychiatry, Osaka University Graduate School of Medicine, Osaka, Japan.
authors: Ryouhei
authors: R
authors: Ishii
authors: 2 UCM-UPM Centre for Biomedical Technology, Department of Cognitive and Computational Neuroscience, Complutense University of Madrid, Madrid, Spain.
authors: Leonides
authors: L
authors: Canuet
authors: 3 The KEY Institute for Brain-Mind Research, University Hospital of Psychiatry, Zurich, Switzerland.|4 Department of Neuropsychiatry, Kansai Medical University, Osaka, Japan.
authors: Roberto D
authors: RD
authors: Pascual-Marqui
authors: 1 Department of Psychiatry, Osaka University Graduate School of Medicine, Osaka, Japan.|5 Nissay Hospital, Osaka, Japan.
authors: Yasunori
authors: Y
authors: Aoki
authors: 4 Department of Neuropsychiatry, Kansai Medical University, Osaka, Japan.
authors: Shunichiro
authors: S
authors: Ikeda
authors: 1 Department of Psychiatry, Osaka University Graduate School of Medicine, Osaka, Japan.
authors: Shunsuke
authors: S
authors: Sato
authors: 1 Department of Psychiatry, Osaka University Graduate School of Medicine, Osaka, Japan.
authors: Yukiko
authors: Y
authors: Suzuki
authors: 1 Department of Psychiatry, Osaka University Graduate School of Medicine, Osaka, Japan.
authors: Hideki
authors: H
authors: Kanemoto
authors: 1 Department of Psychiatry, Osaka University Graduate School of Medicine, Osaka, Japan.
authors: Kenji
authors: K
authors: Yoshiyama
authors: 1 Department of Psychiatry, Osaka University Graduate School of Medicine, Osaka, Japan.
authors: Masao
authors: M
authors: Iwase
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000134:cerebrospinal fluid* / Q000175:diagnosis; D015415:Biomarkers / Q000134:cerebrospinal fluid*; D001921:Brain / Q000503:physiopathology; D004569:Electroencephalography / Q000379:methods; D055590:Electromagnetic Phenomena; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D014057:Tomography, X-Ray Computed / Q000379:methods
chemical_list: D015415:Biomarkers
keywords: Alzheimer’s disease; EEG; LORETA; amyloid-beta; cerebrospinal fluid; functional connectivity; tau