title: Naphthalene Derivatives from the Roots of Pentas parvifolia and Pentas bussei.
abstract: The phytochemical investigation of the CH2Cl2/MeOH (1:1) extract of the roots of Pentas parvifolia led to the isolation of three new naphthalenes, parvinaphthols A (1), B (2), and C (3), two known anthraquinones, and five known naphthalene derivatives. Similar investigation of the roots of Pentas bussei afforded a new polycyclic naphthalene, busseihydroquinone E (4), a new 2,2'-binaphthralenyl-1,1'-dione, busseihydroquinone F (5), and five known naphthalenes. All purified metabolites were characterized by NMR and MS data analyses, whereas the absolute configurations of 3 and 4 were determined by single-crystal X-ray diffraction studies. The E-geometry of compound 5 was supported by DFT-based chemical shift calculations. Compounds 2-4 showed marginal cytotoxicity against the MDA-MB-231 human triple-negative breast cancer cell line with IC50 values ranging from 62.3 to 129.6 μM.
authors: Department of Chemistry, University of Nairobi , P.O. Box 30197-00100, Nairobi, Kenya.|Department of Chemistry and Molecular Biology, University of Gothenburg , SE-412 96 Gothenburg, Sweden.|Department of Chemistry, Jimma University , P.O. Box 378, Jimma, Ethiopia.
authors: Negera
authors: N
authors: Abdissa
authors: Department of Chemistry, Nanoscience Center, University of Jyvaskyla , P.O. Box 35, FI-40014 Jyvaskyla, Finland.
authors: Fangfang
authors: F
authors: Pan
authors: Department of Chemistry and Molecular Biology, University of Gothenburg , SE-412 96 Gothenburg, Sweden.|Sahlgrenska Cancer Centre, University of Gothenburg , Gothenburg SE-405 30, Sweden.
authors: Amra
authors: A
authors: Gruhonjic
authors: Department of Chemistry and Molecular Biology, University of Gothenburg , SE-412 96 Gothenburg, Sweden.
authors: Jürgen
authors: J
authors: Gräfenstein
authors: Sahlgrenska Cancer Centre, University of Gothenburg , Gothenburg SE-405 30, Sweden.
authors: Paul A
authors: PA
authors: Fitzpatrick
authors: Sahlgrenska Cancer Centre, University of Gothenburg , Gothenburg SE-405 30, Sweden.
authors: Göran
authors: G
authors: Landberg
authors: Department of Chemistry, Nanoscience Center, University of Jyvaskyla , P.O. Box 35, FI-40014 Jyvaskyla, Finland.
authors: Kari
authors: K
authors: Rissanen
authors: Department of Chemistry, University of Nairobi , P.O. Box 30197-00100, Nairobi, Kenya.
authors: Abiy
authors: A
authors: Yenesew
authors: Department of Chemistry and Molecular Biology, University of Gothenburg , SE-412 96 Gothenburg, Sweden.|Swedish NMR Centre, University of Gothenburg , Gothenburg SE-405 30, Sweden.
authors: Máté
authors: M
authors: Erdélyi
mesh_terms: D000880:Anthraquinones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000962:Antimalarials / Q000737:chemistry; D018360:Crystallography, X-Ray; D006801:Humans; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D009281:Naphthalenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D019906:Nuclear Magnetic Resonance, Biomolecular; D018517:Plant Roots / Q000737:chemistry; D010963:Plasmodium falciparum / Q000187:drug effects; D019666:Rubiaceae / Q000737:chemistry*
chemical_list: D000880:Anthraquinones; D000962:Antimalarials; D009281:Naphthalenes; C000620731:parvinaphthol A; C000620732:parvinaphthol B; C000620733:parvinaphthol C