title: Copper-Catalyzed Cascade Amination Route to N-Aryl Benzimidazoquinazolinones.
abstract: An efficient one-pot Cu-catalyzed C-H functionalization/two-fold C-N bond formation protocol for the syntheses of N-aryl benzimidazoquinazolinones is being reported. This strategy involves a Cu-catalyzed C-N bond coupling reaction between N-anilinoquinazolinones and aryl/heteroaryl halides followed by acetate ligand-assisted intramolecular C-H amination.a This reaction is high-yielding and straightforward for the synthesis of anti-cancer drug analogues of benzimidazoquinazolinones.
authors: Department of Chemistry, Indian Institute of Technology Bombay , Powai, Mumbai 400076, India.
authors: Arpan
authors: A
authors: Banerjee
authors: Department of Chemistry, Indian Institute of Technology Bombay , Powai, Mumbai 400076, India.
authors: Parthasarathi
authors: P
authors: Subramanian
authors: Department of Chemistry, Indian Institute of Technology Bombay , Powai, Mumbai 400076, India.
authors: Krishna P
authors: KP
authors: Kaliappan
mesh_terms: D000586:Amination; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D052999:Quinazolinones / Q000737:chemistry*; D013057:Spectrum Analysis / Q000379:methods
chemical_list: D000970:Antineoplastic Agents; D052999:Quinazolinones; D003300:Copper