title: Recent advances in cancer drug discovery targeting RAS.
abstract: Mutated RAS is present in 30% of human tumors, appearing in 90% of pancreatic, 45% of colon and 35% of lung cancers. These high occurrences make RAS one of the most important drug targets in oncology. Three decades of effort to target RAS have been unsuccessful in generating drug therapies suggesting that it might represent an 'undruggable' target. However, recent reports highlighting new approaches for targeting RAS have uncovered more information on protein structure and identified new binding pockets. Efforts to target the KRAS G12C mutation specifically have shown promising results whereas other approaches have targeted various protein complexes. These advances could lead to development of new effective cancer drugs targeting RAS.
authors: Center for Healthcare Innovation, Stevens Institute of Technology, 507 River Street, McLean 515, Hoboken, NJ 07030, USA.
authors: Candice Y
authors: CY
authors: Wilson
authors: Center for Healthcare Innovation, Stevens Institute of Technology, 507 River Street, McLean 515, Hoboken, NJ 07030, USA. Electronic address: ptolias@stevens.edu.
authors: Peter
authors: P
authors: Tolias
mesh_terms: D000970:Antineoplastic Agents / Q000494:pharmacology / Q000627:therapeutic use*; D055808:Drug Discovery; D006801:Humans; D009154:Mutation; D009369:Neoplasms / Q000188:drug therapy* / Q000235:genetics / Q000378:metabolism; D020664:Son of Sevenless Proteins / Q000378:metabolism; D018631:ras Proteins / Q000235:genetics* / Q000378:metabolism*
chemical_list: D000970:Antineoplastic Agents; D020664:Son of Sevenless Proteins; D018631:ras Proteins