title: Caffeoylquinic Acid Derivatives Extract of Erigeron multiradiatus Alleviated Acute Myocardial Ischemia Reperfusion Injury in Rats through Inhibiting NF-KappaB and JNK Activations.
abstract: Erigeron multiradiatus (Lindl.) Benth. has been used in Tibet folk medicine to treat various inflammatory diseases. The aim of this study was to investigate antimyocardial ischemia and reperfusion (I/R) injury effect of caffeoylquinic acids derivatives of E. multiradiatus (AE) in vivo and to explain underling mechanism. AE was prepared using the whole plant of E. multiradiatus and contents of 6 caffeoylquinic acids determined through HPLC analysis. Myocardial I/R was induced by left anterior descending coronary artery occlusion for 30 minutes followed by 24 hours of reperfusion in rats. AE administration (10, 20, and 40 mg/kg) inhibited I/R-induced injury as indicated by decreasing myocardial infarct size, reducing of CK and LDH activities, and preventing ST-segment depression in dose-dependent manner. AE decreased cardiac tissue levels of proinflammatory factors TNF-α and IL-6 and attenuated leukocytes infiltration. AE was further demonstrated to significantly inhibit I-κB degradation, nuclear translocation of p-65 and phosphorylation of JNK. Our results suggested that cardioprotective effect of AE could be due to suppressing myocardial inflammatory response and blocking NF-κB and JNK activation pathway. Thus, caffeoylquinic acids might be the active compounds in E. multiradiatus on myocardial ischemia and be a potential natural drug for treating myocardial I/R injury.
authors: Institute of Qinghai-Tibetan Plateau, Southwest University for Nationalities, Chengdu, Sichuan 610041, China.
authors: Zhifeng
authors: 0000-0002-7764-8740
authors: Z
authors: Zhang
authors: Institute of Qinghai-Tibetan Plateau, Southwest University for Nationalities, Chengdu, Sichuan 610041, China.
authors: Yuan
authors: Y
authors: Liu
authors: State Key Laboratories for Quality Research in Chinese Medicines, Macau University of Science and Technology, Macau.
authors: Xuecong
authors: X
authors: Ren
authors: State Key Laboratories for Quality Research in Chinese Medicines, Macau University of Science and Technology, Macau.
authors: Hua
authors: 0000-0002-7025-3690
authors: H
authors: Zhou
authors: Institute of Qinghai-Tibetan Plateau, Southwest University for Nationalities, Chengdu, Sichuan 610041, China.
authors: Kaishun
authors: K
authors: Wang
authors: Department of Medicinal Natural Products, West China School of Pharmacy, Sichuan University, Chengdu, Sichuan 610041, China.
authors: Hao
authors: H
authors: Zhang
authors: State Key Laboratories for Quality Research in Chinese Medicines, Macau University of Science and Technology, Macau.
authors: Pei
authors: 0000-0003-3095-9223
authors: P
authors: Luo
mesh_terms: D000818:Animals; D049919:Erigeron / Q000737:chemistry*; D048031:JNK Mitogen-Activated Protein Kinases / Q000378:metabolism*; D008297:Male; D017202:Myocardial Ischemia / Q000188:drug therapy* / Q000276:immunology* / Q000378:metabolism; D015428:Myocardial Reperfusion Injury / Q000188:drug therapy* / Q000276:immunology* / Q000378:metabolism / Q000601:surgery; D009206:Myocardium / Q000276:immunology* / Q000378:metabolism*; D016328:NF-kappa B / Q000378:metabolism*; D010936:Plant Extracts / Q000627:therapeutic use*; D011801:Quinic Acid / Q000031:analogs & derivatives* / Q000737:chemistry; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D016328:NF-kappa B; D010936:Plant Extracts; C472707:caffeoylquinic acid; D011801:Quinic Acid; D048031:JNK Mitogen-Activated Protein Kinases