title: Systemic sarcoidosis with hypercalcaemia, hypothalamic-pituitary dysfunction and thyroid involvement.
abstract: Sarcoidosis is a multisystem granulomatous disorder. The lungs are the principal organs affected, however, extrapulmonary involvement including disorders of the pituitary and thyroid glands has been reported but presentation with multiple endocrine manifestations is rare. We report the case of a 36-year-old African-American woman who presented with hypercalcaemia, abnormal thyroid function studies and secondary amenorrhoea. On workup including laboratory, radiological testing and biopsy she was diagnosed with sarcoidosis with multi-organ involvement. Endocrine manifestations included non-parathyroid hormone mediated hypercalcaemia related to sarcoidosis, thyroid involvement with sarcoidosis and hypothalamic-pituitary involvement with a sellar and suprasellar mass associated with secondary adrenal insufficiency, secondary hypogonadism, growth hormone deficiency and secondary hypothyroidism. We report to the best of our knowledge the first case of simultaneous multiple endocrine manifestations of sarcoidosis that included hypercalcaemia, hypopituitarism and sarcoidosis of the thyroid gland.
authors: Department of Endocrinology and Metabolism, Louisiana State University Health Sciences Center Shreveport, Shreveport, Louisiana, USA.
authors: Nassib
authors: N
authors: Alsahwi
authors: Department of Endocrinology and Metabolism, Louisiana State University Health Sciences Center Shreveport, Shreveport, Louisiana, USA.
authors: Delali
authors: D
authors: Blavo
authors: Department of Endocrinology and Metabolism, Louisiana State University Health Sciences Center Shreveport, Shreveport, Louisiana, USA.
authors: Harsha
authors: H
authors: Karanchi
mesh_terms: D000309:Adrenal Insufficiency / Q000150:complications; D000328:Adult; D005260:Female; D013006:Growth Hormone / Q000172:deficiency; D006801:Humans; D006934:Hypercalcemia / Q000209:etiology; D007006:Hypogonadism / Q000150:complications; D007018:Hypopituitarism / Q000150:complications* / Q000000981:diagnostic imaging; D008279:Magnetic Resonance Imaging; D012507:Sarcoidosis / Q000150:complications* / Q000473:pathology; D013959:Thyroid Diseases / Q000150:complications* / Q000473:pathology
chemical_list: D013006:Growth Hormone