title: Drug repurposing: a new front in the war against Staphylococcus aureus.
abstract: Staphylococcus aureus continues its domination of worldwide bacterial infection rates, thereby remaining a pathogen of significant public health interest. A major reason for its continued success is its ability to acquire and maintain diverse drug resistance mechanisms, leading to a paucity of antimicrobials active against it, concomitantly leading to a continuous search for new antimicrobial agents. However, with the withdrawal of the major pharmaceutical firms from the anti-infective area, drug repurposing has provided a potential boost to the drug pipeline. In this review, we provide an overview of the currently approved drugs with repurposing potential against Staphylococcus aureus, thus augmenting the classical drug discovery pathway.
authors: Department of Microbiology, CSIR-Central Drug Research Institute, Lucknow 226031, Uttar Pradesh, India.
authors: Swetarka
authors: S
authors: Das
authors: Department of Microbiology, CSIR-Central Drug Research Institute, Lucknow 226031, Uttar Pradesh, India.
authors: Arunava
authors: A
authors: Dasgupta
authors: Department of Microbiology, CSIR-Central Drug Research Institute, Lucknow 226031, Uttar Pradesh, India.
authors: Sidharth
authors: S
authors: Chopra
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D058492:Drug Repositioning / Q000379:methods / Q000639:trends*; D024881:Drug Resistance, Bacterial; D006801:Humans; D013203:Staphylococcal Infections / Q000188:drug therapy / Q000382:microbiology*; D013211:Staphylococcus aureus / Q000187:drug effects* / Q000235:genetics / Q000502:physiology
chemical_list: D000900:Anti-Bacterial Agents
keywords: MRSA; Staphylococcus aureus; antibiotics; drug repurposing