title: Examination of Pyridazine as a Possible Scaffold for Nucleophilic Catalysis.
abstract: Pyridazines with amino groups positioned para to each aromatic ring nitrogen and fixed in six-membered rings were prepared. The representative symmetric amino N-Et derivative was found to slightly exceed DMAP in catalytic activity in the acetylation reaction of a tertiary alcohol in C6D6. Nucleophilicity eclipsing that of DMAP was established in competitive reactions using phenacyl bromide as the electrophile, and the unsymmetric N-Et derivative was revealed to have even higher nucleophilicity.
authors: Department of Chemistry, Graduate School of Science, Hiroshima University , 1-3-1 Kagamiyama, Higashi-Hiroshima 739-8526, Japan.
authors: Airi
authors: A
authors: Tamaki
authors: Department of Chemistry, Graduate School of Science, Hiroshima University , 1-3-1 Kagamiyama, Higashi-Hiroshima 739-8526, Japan.|Center for Quantum Life Sciences, Hiroshima University , 1-3-1 Kagamiyama, Higashi-Hiroshima 739-8526, Japan.
authors: Satoshi
authors: S
authors: Kojima
authors: Department of Chemistry, Graduate School of Science, Hiroshima University , 1-3-1 Kagamiyama, Higashi-Hiroshima 739-8526, Japan.
authors: Yohsuke
authors: Y
authors: Yamamoto