title: Chronic kidney disease in pregnancy: Maternal and fetal outcomes and progression of kidney disease.
abstract: BACKGROUND
  There is a paucity of Australian data regarding renal disease in pregnancy. We undertook a retrospective cohort study at a tertiary institution to examine the impact of renal disease on pregnancy outcomes and the effect of pregnancy on disease progression.
  
  
  METHODS
  A total of 55 pregnancies of patients with renal disease admitted from 2003 to 2010 to the Royal Brisbane and Women's Hospital were analysed. Pre-conception variables, fetal/delivery and maternal outcomes were analysed in this group and in a control group of women with normal kidney function pre-pregnancy.
  
  
  RESULTS
  Of the 55 pregnancies, 71% experienced pre-term delivery, 38% had intra-uterine growth restriction and 62% required caesarean section. Of all, 60% of neonates required neonatal intensive care unit (NICU) admission and six perinatal deaths occurred. Of all, 67% of women suffered preeclampsia, 47% anaemia and 3 patients required dialysis in pregnancy. Postpartum deterioration of renal function occurred in patients with pre-conception chronic kidney disease stage 3-5.
  
  
  CONCLUSIONS
  Chronic kidney disease of all stages is a risk factor for adverse pregnancy outcomes. In a tertiary institution however, there is a high rate of successful pregnancy (84%).
authors: School of Medicine, University of Queensland, Brisbane, Queensland, Australia; Royal Brisbane and Women's Hospital, Brisbane, Queensland, Australia.
authors: Natalie L
authors: NL
authors: Davidson
authors: Department of Obstetric Medicine/Endocrinology, Royal Brisbane and Women's Hospital, Brisbane, Queensland, Australia.
authors: Penny
authors: P
authors: Wolski
authors: School of Medicine, University of Queensland, Brisbane, Queensland, Australia.
authors: Leonie K
authors: LK
authors: Callaway
authors: Department of Internal Medicine and Maternity Services, Royal Brisbane and Women's Hospital, Brisbane, Queensland, Australia.
authors: Helen L
authors: HL
authors: Barrett
authors: Department of Obstetric Medicine, Royal Brisbane and Women's Hospital, Brisbane, Queensland, Australia.
authors: Narelle
authors: N
authors: Fagermo
authors: Department of Obstetric Medicine, Royal Brisbane and Women's Hospital, Brisbane, Queensland, Australia.
authors: Karin
authors: K
authors: Lust
authors: Department of Internal Medicine, Nambour General Hospital, Brisbane, Queensland, Australia.
authors: Rebekah E
authors: RE
authors: Shakhovskoy
keywords: Chronic kidney disease; hypertension; maternal outcomes; pregnancy; proteinuria