title: MicroRNA Regulators of Anxiety and Metabolic Disorders.
abstract: Anxiety-related and metabolic disorders are under intense research focus. Anxiety-induced microRNAs (miRNAs) are emerging as regulators that are not only capable of suppressing inflammation but can also induce metabolic syndrome-related processes. We summarize here evidence linking miRNA pathways which share regulatory networks in metabolic and anxiety-related conditions. In particular, miRNAs involved in these disorders include regulators of acetylcholine signaling in the nervous system and their accompanying molecular machinery. These have been associated with anxiety-prone states in individuals, while also acting as inflammatory suppressors. In peripheral tissues, altered miRNA pathways can lead to dysregulated metabolism. Common pathways in metabolic and anxiety-related phenomena might offer an opportunity to reclassify 'healthy' and 'unhealthy', as well as metabolic and anxiety-prone biological states, and inform putative strategies to treat these disorders.
authors: Department of Internal Medicine 'E', Tel Aviv Sourasky Medical Center, Tel Aviv, Israel; Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.
authors: Chanan
authors: C
authors: Meydan
authors: Department of Internal Medicine 'E', Tel Aviv Sourasky Medical Center, Tel Aviv, Israel; The Edmond and Lily Safra Center of Brain Science and the Department of Biological Chemistry, The Hebrew University of Jerusalem, Jerusalem 91904, Israel.
authors: Shani
authors: S
authors: Shenhar-Tsarfaty
authors: The Edmond and Lily Safra Center of Brain Science and the Department of Biological Chemistry, The Hebrew University of Jerusalem, Jerusalem 91904, Israel. Electronic address: hermona.soreq@mail.huji.ac.il.
authors: Hermona
authors: H
authors: Soreq
mesh_terms: D000109:Acetylcholine / Q000235:genetics / Q000378:metabolism; D000818:Animals; D001007:Anxiety / Q000150:complications* / Q000235:genetics* / Q000378:metabolism; D005786:Gene Expression Regulation; D006801:Humans; D007249:Inflammation / Q000150:complications / Q000235:genetics / Q000378:metabolism; D008659:Metabolic Diseases / Q000150:complications* / Q000235:genetics* / Q000378:metabolism; D035683:MicroRNAs / Q000235:genetics* / Q000378:metabolism; D015398:Signal Transduction
chemical_list: D035683:MicroRNAs; D000109:Acetylcholine
keywords: anxiety; cholinergic; metabolic disorder; miRNAs; obesity