title: Risk factors for mortality in patients with Stenotrophomonas maltophilia bacteremia.
abstract: Stenotrophomonas maltophilia is a nosocomial pathogen associated with high morbidity and mortality, particularly in immunocompromised or critically ill patients. In this study, we investigated the risk factors for mortality in patients with S. maltophilia bacteremia.Retrospectively, medical records from all patients with S. maltophilia bacteremia between December 2005 and 2014 at Severance Hospital, a 2000-bed tertiary care hospital in Seoul, Korea, were reviewed. Analysis was performed to identify factors associated with 28-day mortality.In total, 142 bacteremia patients were enrolled in this study. The overall 28-day mortality rate was 36.6%. Based on the univariate analysis, hematologic malignancy (P = 0.015), Sepsis-related Organ Failure Assessment (SOFA) score (P < 0.001) and the removal of a central venous catheter (CVC) (P = 0.040) were significantly related to mortality. In the intensive care unit patients, the Acute Physiology and Chronic Health Evaluation II score (P = 0.001) also had significance. Based on the multivariate analysis, the SOFA score (odds ratio [OR] = 1.323; 95% confidence interval [CI]: 1.159, 1.509; P < 0.001) and removal of the CVC (OR = 0.330; 95% CI: 0.109, 0.996; P = 0.049) were independent factors associated with mortality.Our results suggest that removing a CVC may considerably reduce mortality in patients with S. maltophilia bacteremia.
authors: Department of Internal Medicine AIDS Research Institute, Yonsei University College of Medicine, Seoul, Korea.
authors: Yong Duk
authors: YD
authors: Jeon
authors: Woo Yong
authors: WY
authors: Jeong
authors: Moo Hyun
authors: MH
authors: Kim
authors: In Young
authors: IY
authors: Jung
authors: Mi Young
authors: MY
authors: Ahn
authors: Hea Won
authors: HW
authors: Ann
authors: Jin Young
authors: JY
authors: Ahn
authors: Sang Hoon
authors: SH
authors: Han
authors: Jun Yong
authors: JY
authors: Choi
authors: Young Goo
authors: YG
authors: Song
authors: June Myung
authors: JM
authors: Kim
authors: Nam Su
authors: NS
authors: Ku
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D002405:Catheterization, Central Venous / Q000009:adverse effects*; D002423:Cause of Death; D015331:Cohort Studies; D003428:Cross Infection / Q000209:etiology / Q000401:mortality; D016208:Databases, Factual; D005260:Female; D016905:Gram-Negative Bacterial Infections / Q000209:etiology / Q000401:mortality* / Q000503:physiopathology; D017052:Hospital Mortality; D006801:Humans; D053208:Kaplan-Meier Estimate; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D012189:Retrospective Studies; D018570:Risk Assessment; D012737:Sex Factors; D020615:Stenotrophomonas maltophilia / Q000276:immunology*; D016019:Survival Analysis; D014546:Urinary Catheterization / Q000009:adverse effects*