title: Anti-CD44 antibodies inhibit both mTORC1 and mTORC2: a new rationale supporting CD44-induced AML differentiation therapy.
authors: Biological and Environmental Sciences and Engineering Division, King Abdullah University of Science and Technology (KAUST), Thuwal, Saudi Arabia.
authors: S Z
authors: SZ
authors: Gadhoum
authors: Biological and Environmental Sciences and Engineering Division, King Abdullah University of Science and Technology (KAUST), Thuwal, Saudi Arabia.
authors: N Y
authors: NY
authors: Madhoun
authors: Biological and Environmental Sciences and Engineering Division, King Abdullah University of Science and Technology (KAUST), Thuwal, Saudi Arabia.
authors: A F
authors: AF
authors: Abuelela
authors: Biological and Environmental Sciences and Engineering Division, King Abdullah University of Science and Technology (KAUST), Thuwal, Saudi Arabia.
authors: J S
authors: JS
authors: Merzaban
mesh_terms: D000911:Antibodies, Monoclonal / Q000276:immunology*; D002454:Cell Differentiation / Q000276:immunology*; D045744:Cell Line, Tumor; D000071316:Forkhead Box Protein O3 / Q000378:metabolism; D006801:Humans; D018960:Hyaluronan Receptors / Q000276:immunology*; D015470:Leukemia, Myeloid, Acute / Q000276:immunology / Q000473:pathology*; D000076222:Mechanistic Target of Rapamycin Complex 1 / Q000276:immunology*; D000076225:Mechanistic Target of Rapamycin Complex 2 / Q000276:immunology*; D019869:Phosphatidylinositol 3-Kinases / Q000378:metabolism; D051057:Proto-Oncogene Proteins c-akt / Q000378:metabolism
chemical_list: D000911:Antibodies, Monoclonal; C497483:CD44 protein, human; C499517:FOXO3 protein, human; D000071316:Forkhead Box Protein O3; D018960:Hyaluronan Receptors; D019869:Phosphatidylinositol 3-Kinases; D000076222:Mechanistic Target of Rapamycin Complex 1; D000076225:Mechanistic Target of Rapamycin Complex 2; D051057:Proto-Oncogene Proteins c-akt