title: [Laboratory-Based Clinical Research I am Aiming for].
abstract: We have pursued the clinical introduction of assays of lysophospholipids and related proteins. One such example is the multi-functional lysophospholipid mediator lysophosphatidic acid (LPA), which is produced from lysophosphatidylcholine (LPC) through the lysophospholipase D (lysoPLD) activity of autotaxin (ATX) in body fluids. Determination of the LPA concentration in body fluids, especially plasma, is clinically relevant and important for diagnostic purposes, and we have succeeded in the elucidation of disease states in which the levels of LPA/ATX are altered; ATX is promising as a biomarker for several diseases. The department of clinical laboratory in the hospital is a suitable section to perform such research, for which sophisticated assays and sampling techniques are needed.
authors: Yutaka
authors: Y
authors: Yatomi
mesh_terms: D015415:Biomarkers / Q000032:analysis; D001826:Body Fluids / Q000737:chemistry; D019411:Clinical Laboratory Techniques; D002985:Clinical Protocols; D006801:Humans; D008246:Lysophospholipids / Q000032:analysis; D013677:Medical Laboratory Science; D010727:Phosphoric Diester Hydrolases / Q000032:analysis; D000099189:Lysophospholipase D
chemical_list: D015415:Biomarkers; D008246:Lysophospholipids; D010727:Phosphoric Diester Hydrolases; D000099189:Lysophospholipase D; C032881:lysophosphatidic acid