title: Chemo-Enzymatic Synthesis of Oligoglycerol Derivatives.
abstract: A cleaner and greener method has been developed and used to synthesize 14 different functionalized oligomer derivatives of glycerol in moderate 29%-39% yields over three steps. After successive regioselective enzymatic acylation of the primary hydroxyl groups, etherification or esterification of the secondary hydroxyl groups and chemoselective enzymatic saponification, the target compounds can efficiently be used as versatile building blocks in organic and supramolecular chemistry.
authors: Department of Chemistry, University of Delhi, Delhi 110007, India. abhikmcdu@gmail.com.
authors: Abhishek K
authors: AK
authors: Singh
authors: Université de Technologie de Compiègne (UTC), CS 60319, Compiègne Cedex 60203, France. remi.nguyen@utc.fr.
authors: Remi
authors: R
authors: Nguyen
authors: Université de Technologie de Compiègne (UTC), CS 60319, Compiègne Cedex 60203, France. ngaly@laposte.net.
authors: Nicolas
authors: N
authors: Galy
authors: Institut für Chemie und Biochemie, Freie Universität Berlin, Takustraße 3, Berlin 14195, Germany. rainer.haag@gmx.de.
authors: Rainer
authors: R
authors: Haag
authors: Department of Chemistry, University of Delhi, Delhi 110007, India. sk.sharma90@gmail.com.
authors: Sunil K
authors: SK
authors: Sharma
authors: Université de Technologie de Compiègne (UTC), CS 60319, Compiègne Cedex 60203, France. christophe.len@utc.fr.
authors: Christophe
authors: C
authors: Len
mesh_terms: D004800:Enzymes, Immobilized; D004951:Esterification; D005656:Fungal Proteins; D005990:Glycerol / Q000138:chemical synthesis* / Q000737:chemistry*; D008049:Lipase / Q000737:chemistry*; D011108:Polymers / Q000138:chemical synthesis* / Q000737:chemistry*
chemical_list: D004800:Enzymes, Immobilized; D005656:Fungal Proteins; D011108:Polymers; C043941:polyglycerol; C093667:Novozyme 435; D008049:Lipase; D005990:Glycerol
keywords: Novozym 435; building blocks; chemo-enzymatic; glycerol oligomers; regioselectivity