title: A Randomized Controlled Trial of Compression Rates during Cardiopulmonary Resuscitation.
abstract: The objective of this study was to compare the efficacy of cardiopulmonary resuscitation (CPR) with 120 compressions per minute (CPM) to CPR with 100 CPM in patients with non-traumatic out-of-hospital cardiac arrest. We randomly assigned patients with non-traumatic out-of-hospital cardiac arrest into two groups upon arrival to the emergency department (ED). The patients received manual CPR either with 100 CPM (CPR-100 group) or 120 CPM (CPR-120 group). The primary outcome measure was sustained restoration of spontaneous circulation (ROSC). The secondary outcome measures were survival discharge from the hospital, one-month survival, and one-month survival with good functional status. Of 470 patients with cardiac arrest, 136 patients in the CPR-100 group and 156 patients in the CPR-120 group were included in the final analysis. A total of 69 patients (50.7%) in the CPR-100 group and 67 patients (42.9%) in the CPR-120 group had ROSC (absolute difference, 7.8% points; 95% confidence interval [CI], -3.7 to 19.2%; P = 0.183). The rates of survival discharge from the hospital, one-month survival, and one-month survival with good functional status were not different between the two groups (16.9% vs. 12.8%, P = 0.325; 12.5% vs. 6.4%, P = 0.073; 5.9% vs. 2.6%, P = 0.154, respectively). We did not find differences in the resuscitation outcomes between those who received CPR with 100 CPM and those with 120 CPM. However, a large trial is warranted, with adequate power to confirm a statistically non-significant trend toward superiority of CPR with 100 CPM. (
  
  
  BACKGROUND
  www.cris.nih.go.kr, cris.nih.go.kr number, KCT0000231).
authors: Department of Emergency Medicine, Wonju College of Medicine, Yonsei University, Wonju, Korea. shwang@yonsei.ac.kr.
authors: Sung Oh
authors: http://orcid.org/0000-0003-4585-3181
authors: SO
authors: Hwang
authors: Department of Emergency Medicine, Wonju College of Medicine, Yonsei University, Wonju, Korea.
authors: Kyoung Chul
authors: http://orcid.org/0000-0003-1818-2466
authors: KC
authors: Cha
authors: Department of Emergency Medicine, Seoul National University Bundang Hospital, Seongnam, Korea.
authors: Kyuseok
authors: http://orcid.org/0000-0002-7991-9428
authors: K
authors: Kim
authors: Department of Emergency Medicine, Seoul National University Bundang Hospital, Seongnam, Korea.
authors: You Hwan
authors: http://orcid.org/0000-0002-9507-7603
authors: YH
authors: Jo
authors: Department of Emergency Medicine, Yonsei University Kangnam Severance Hospital, Seoul, Korea.
authors: Sung Phil
authors: http://orcid.org/0000-0002-3074-011X
authors: SP
authors: Chung
authors: Department of Emergency Medicine, Yonsei University Kangnam Severance Hospital, Seoul, Korea.
authors: Je Sung
authors: http://orcid.org/0000-0002-2074-6745
authors: JS
authors: You
authors: Department of Emergency Medicine, Seoul National University Boramae Hospital, Seoul, Korea.
authors: Jonghwan
authors: http://orcid.org/0000-0002-7121-2137
authors: J
authors: Shin
authors: Department of Emergency Medicine, Seoul National University Boramae Hospital, Seoul, Korea.
authors: Hui Jai
authors: http://orcid.org/0000-0002-9064-4680
authors: HJ
authors: Lee
authors: Department of Emergency Medicine, Yonsei University Severance Hospital, Seoul, Korea.
authors: Yoo Seok
authors: http://orcid.org/0000-0003-1543-4664
authors: YS
authors: Park
authors: Department of Emergency Medicine, Yonsei University Severance Hospital, Seoul, Korea.
authors: Seunghwan
authors: http://orcid.org/0000-0001-6783-3849
authors: S
authors: Kim
authors: Department of Emergency Medicine, Ajou University Hospital, Suwon, Korea.
authors: Sang Cheon
authors: http://orcid.org/0000-0003-2271-3434
authors: SC
authors: Choi
authors: Department of Emergency Medicine, Ajou University Hospital, Suwon, Korea.
authors: Eun Jung
authors: http://orcid.org/0000-0001-7854-0961
authors: EJ
authors: Park
authors: Department of Emergency Medicine, Asan Medical Center, Ulsan University, Seoul, Korea.
authors: Won Young
authors: http://orcid.org/0000-0002-6904-5966
authors: WY
authors: Kim
authors: Department of Emergency Medicine, Asan Medical Center, Ulsan University, Seoul, Korea.
authors: Dong Woo
authors: http://orcid.org/0000-0001-8104-0247
authors: DW
authors: Seo
authors: Department of Emergency Medicine, Korea University Ansan Hospital, Ansan, Korea.
authors: Sungwoo
authors: http://orcid.org/0000-0001-9950-3449
authors: S
authors: Moon
authors: Department of Emergency Medicine, Korea University Ansan Hospital, Ansan, Korea.
authors: Gapsu
authors: http://orcid.org/0000-0003-0205-1269
authors: G
authors: Han
authors: Department of Emergency Medicine, Kyung Hee University Hospital, Seoul, Korea.
authors: Han Sung
authors: http://orcid.org/0000-0001-7477-5405
authors: HS
authors: Choi
authors: Department of Emergency Medicine, Hanyang University Hospital, Seoul, Korea.
authors: Hyunggoo
authors: http://orcid.org/0000-0002-9522-2532
authors: H
authors: Kang
authors: Department of Emergency Medicine, Hallym University Saint Sacred Hospital, Anyang, Korea.
authors: Seung Min
authors: http://orcid.org/0000-0002-3594-8403
authors: SM
authors: Park
authors: Department of Emergency Medicine, Seoul National University Hospital, Seoul, Korea.
authors: Woon Yong
authors: http://orcid.org/0000-0002-3343-5030
authors: WY
authors: Kwon
authors: Institute of Lifestyle Medicine, Yonsei University Wonju College of Medicine, Wonju, Korea.
authors: Eunhee
authors: http://orcid.org/0000-0002-3449-0672
authors: E
authors: Choi
mesh_terms: D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D016887:Cardiopulmonary Resuscitation / Q000379:methods*; D004632:Emergency Medical Services; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D058687:Out-of-Hospital Cardiac Arrest / Q000401:mortality / Q000628:therapy*; D010351:Patient Discharge; D012737:Sex Factors; D016019:Survival Analysis; D016896:Treatment Outcome
keywords: Basic Life Support; Cardiac Arrest; Cardiopulmonary Resuscitation