title: Assessment of bone mineral density and bone metabolism in young male adults recently diagnosed with systemic lupus erythematosus in China.
abstract: Objective Systemic lupus erythematosus (SLE) is a chronic inflammatory autoimmune disease. However, the exact mechanism underlying SLE-related osteopenia and osteoporosis in patients newly diagnosed with SLE remains unknown. Methods 60 male subjects with SLE aged 20-30 years were enrolled. Serum osteocalcin was examined as a marker of bone formation and type I collagen degradation products (β-crosslaps) as markers of bone resorption. Lumbar spine (L1-L4) and total hip bone mineral density (BMD) were determined by dual energy X-ray absorption (DXA). Results Among the 60 subjects with SLE at the time of diagnosis, the cohort showed a significant reduction of osteocalcin (12.62 ± 2.16 ng/mL), and serum β-crosslaps level (992.6 ± 162.6 pg/mL) was markedly elevated. Univariate correlation analyses revealed negative correlations between osteocalcin and SLEDAI, dsDNA antibody and β-crosslaps. A positive correlation was also observed between osteocalcin and C3, C4, 25-OH vitamin D, BMD L1-L4 and BMD total hip (see Table 3). Osteocalcin and β-crosslaps were strongly associated with SLE disease activity by multiple stepwise logistic regression analysis. Conclusion Osteocalcin was negatively associated with SLE disease activity, and β-crosslaps was positively associated with SLE disease activity, suggesting SLE disease activity itself directly contributed to the development of SLE-associated osteopenia and osteoporosis.
authors: 1 Department of Respiratory, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.|2 Critical Care Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
authors: Qinyue
authors: Q
authors: Guo
authors: 3 Department of Rheumatology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
authors: Ping
authors: P
authors: Fan
authors: 3 Department of Rheumatology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
authors: Jing
authors: J
authors: Luo
authors: 4 Center for Translational Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
authors: Shufang
authors: S
authors: Wu
authors: 5 Key Laboratory of Environment and Genes Related to Diseases, Medical School of Xi'an Jiaotong University, Xi'an, China.
authors: Hongzhi
authors: H
authors: Sun
authors: 3 Department of Rheumatology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
authors: Lan
authors: L
authors: He
authors: 1 Department of Respiratory, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
authors: Bo
authors: B
authors: Zhou
mesh_terms: D015502:Absorptiometry, Photon; D000328:Adult; D015415:Biomarkers / Q000097:blood; D015992:Body Mass Index; D015519:Bone Density; D002681:China; D003094:Collagen / Q000097:blood; D006801:Humans; D016015:Logistic Models; D008159:Lumbar Vertebrae / Q000000981:diagnostic imaging; D008180:Lupus Erythematosus, Systemic / Q000150:complications*; D008297:Male; D015675:Osteocalcin / Q000097:blood; D010024:Osteoporosis / Q000000981:diagnostic imaging*; D010446:Peptide Fragments / Q000097:blood; D014807:Vitamin D / Q000097:blood; D055815:Young Adult
chemical_list: D015415:Biomarkers; D010446:Peptide Fragments; C110762:glutamyl-lysyl-alanyl-histidyl-aspartyl-glycyl-glycyl-arginine; D015675:Osteocalcin; D014807:Vitamin D; D003094:Collagen
keywords: Bone metabolism; bone mineral density; osteocalcin; systemic lupus erythematosus; β-crosslaps