title: Adult obsessive-compulsive disorder and quality of life outcomes: A systematic review and meta-analysis.
abstract: In the current literature, there are no meta-analyses assessing quality of life (QOL) in patients with obsessive-compulsive disorder (OCD). Knowledge of QOL domains mainly impaired in OCD could provide specific areas for intervention. The current meta-analysis assessed differences in global, work and social, family, and emotional QOL outcomes between patients with OCD and heathy controls. Age, gender and OCD severity were examined as moderators. Case-control studies were included if patients with primary OCD were compared with controls on QOL outcomes. Electronic databases (1966-October 2014) were searched. Thirteen case-control studies were included (n=26,015). Patients with OCD had significantly lower scores on QOL relative to controls, with moderate effect sizes on global QOL and large effect size on work and social, emotional and family QOL outcomes. Studies using higher percentages of female patients and patients with less severe OCD symptoms reported significantly lower QOL outcomes for patients with OCD than controls. Studies comparing patients with OCD and patients with other psychiatric disorders were not included. Treatments should address QOL in OCD, particularly emotional QOL. Additional strategies targeting QOL should be implemented for female patients with less severe OCD symptoms.
authors: Department of Medical Sciences, Surgery and Neurosciences, Santa Maria alle Scotte University Hospital of Siena, viale Bracci 16, 53100 Siena, Italy. Electronic address: coluccia@unisi.it.
authors: Anna
authors: A
authors: Coluccia
authors: Department of Molecular Medicine, University of Siena School of Medicine and Department of Mental Health, University of Siena Medical Center (AOUS), viale Bracci 16, 53100 Siena, Italy.
authors: Andrea
authors: A
authors: Fagiolini
authors: Department of Medical Sciences, Surgery and Neurosciences, Santa Maria alle Scotte University Hospital of Siena, viale Bracci 16, 53100 Siena, Italy.
authors: Fabio
authors: F
authors: Ferretti
authors: Department of Medical Sciences, Surgery and Neurosciences, Santa Maria alle Scotte University Hospital of Siena, viale Bracci 16, 53100 Siena, Italy.
authors: Andrea
authors: A
authors: Pozza
authors: Department of Molecular Medicine, University of Siena School of Medicine and Department of Mental Health, University of Siena Medical Center (AOUS), viale Bracci 16, 53100 Siena, Italy.
authors: Giulia
authors: G
authors: Costoloni
authors: Department of Molecular Medicine, University of Siena School of Medicine and Department of Mental Health, University of Siena Medical Center (AOUS), viale Bracci 16, 53100 Siena, Italy.
authors: Simone
authors: S
authors: Bolognesi
authors: Department of Molecular Medicine, University of Siena School of Medicine and Department of Mental Health, University of Siena Medical Center (AOUS), viale Bracci 16, 53100 Siena, Italy.
authors: Arianna
authors: A
authors: Goracci
mesh_terms: D000328:Adult; D006801:Humans; D009771:Obsessive-Compulsive Disorder / Q000523:psychology*; D011788:Quality of Life / Q000523:psychology*
keywords: Case–control studies; Functioning; Meta-analysis; Obsessive–compulsive disorder; Quality of life; Systematic review