title: Stabilisation of metastable polymorphs: the case of paracetamol form III.
abstract: The design of a melt synthesis of the first air-stable formulation of the metastable form III of paracetamol is derived from thermo-spectroscopic and thermo-diffraction experiments. Melt crystallisation in the presence of β-1,4-saccharides produces form III selectively and the excipients appear to act as stabilising 'active' templates of the metastable polymorph.
authors: School of Chemistry and Forensic Sciences, University of Bradford, Richmond Road, Bradford, BD7 1DP, UK.
authors: Richard
authors: R
authors: Telford
authors: Colin C
authors: CC
authors: Seaton
authors: Alexander
authors: A
authors: Clout
authors: Asma
authors: A
authors: Buanz
authors: Simon
authors: S
authors: Gaisford
authors: Gareth R
authors: GR
authors: Williams
authors: Timothy J
authors: TJ
authors: Prior
authors: Chidera H
authors: CH
authors: Okoye
authors: Tasnim
authors: T
authors: Munshi
authors: Ian J
authors: IJ
authors: Scowen