title: Supersonic shearwave elastography in the assessment of liver fibrosis for postoperative patients with biliary atresia.
abstract: To explore an effective noninvasive tool for monitoring liver fibrosis of children with biliary atresia (BA) is important but evidences are limited. This study is to investigate the predictive accuracy of supersonic shearwave elastography (SSWE) in liver fibrosis for postoperative patients with BA and to compare it with aspartate aminotransferase to platelet ratio index (APRI) and fibrosis-4 (FIB-4). 24 patients with BA received SSWE and laboratory tests before scheduled for liver biopsy. Spearman rank coefficient and receiver operating characteristic (ROC) were used to analyze data. Metavir scores were F0 in 3, F1 in 2, F2 in 4, F3 in 7 and F4 in 8 patients. FIB-4 failed to correlate with fibrosis stage. The areas under the ROC curves of SSWE, APRI and their combination were 0.79, 0.65 and 0.78 for significant fibrosis, 0.81, 0.64 and 0.76 for advanced fibrosis, 0.82, 0.56 and 0.84 for cirrhosis. SSWE values at biopsy was correlated with platelet count (r = -0.426, P = 0.038), serum albumin (r = -0.670, P < 0.001), total bilirubin (r = 0.419, P = 0.041) and direct bilirubin levels (r = 0.518, P = 0.010) measured at 6 months after liver biopsy. Our results indicate that SSWE is a more promising tool to assess liver fibrosis than APRI and FIB-4 in children with BA.
authors: Department of Medical Ultrasonics, Institute of Diagnostic and Interventional Ultrasound , The First Affiliated Hospital of Sun Yat-sen University, No.58 Zhongshan Road 2, Guangzhou, 510080, P.R. China.
authors: Shuling
authors: S
authors: Chen
authors: Department of pathology , The First Affiliated Hospital of Sun Yat-sen University, No.58 Zhongshan Road 2, Guangzhou, 510080, P.R. China.
authors: Bing
authors: B
authors: Liao
authors: Department of pediatric surgery, The First Affiliated Hospital of Sun Yat-sen University, Sun Yat-sen University, Guangzhou 510080, P. R. China.
authors: Zhihai
authors: Z
authors: Zhong
authors: Department of Medical Ultrasonics, Institute of Diagnostic and Interventional Ultrasound , The First Affiliated Hospital of Sun Yat-sen University, No.58 Zhongshan Road 2, Guangzhou, 510080, P.R. China.
authors: Yanling
authors: Y
authors: Zheng
authors: Department of Medical Ultrasonics, Institute of Diagnostic and Interventional Ultrasound , The First Affiliated Hospital of Sun Yat-sen University, No.58 Zhongshan Road 2, Guangzhou, 510080, P.R. China.
authors: Baoxian
authors: B
authors: Liu
authors: Department of Medical Ultrasonics, Institute of Diagnostic and Interventional Ultrasound , The First Affiliated Hospital of Sun Yat-sen University, No.58 Zhongshan Road 2, Guangzhou, 510080, P.R. China.
authors: Quanyuan
authors: Q
authors: Shan
authors: Department of Medical Ultrasonics, Institute of Diagnostic and Interventional Ultrasound , The First Affiliated Hospital of Sun Yat-sen University, No.58 Zhongshan Road 2, Guangzhou, 510080, P.R. China.
authors: Xiaoyan
authors: X
authors: Xie
authors: Department of Medical Ultrasonics, Institute of Diagnostic and Interventional Ultrasound , The First Affiliated Hospital of Sun Yat-sen University, No.58 Zhongshan Road 2, Guangzhou, 510080, P.R. China.
authors: Luyao
authors: L
authors: Zhou
mesh_terms: D001656:Biliary Atresia / Q000150:complications* / Q000473:pathology*; D001774:Blood Chemical Analysis / Q000379:methods; D003955:Diagnostic Tests, Routine / Q000379:methods*; D054459:Elasticity Imaging Techniques / Q000379:methods*; D006801:Humans; D008103:Liver Cirrhosis / Q000175:diagnosis* / Q000473:pathology*; D012372:ROC Curve