title: Antibacterial ability and osteogenic activity of porous Sr/Ag-containing TiO2 coatings.
abstract: Implant-associated infection and poor osseointegration remains a major clinical challenge in Ti-based implant materials. A versatile strategy to endow Ti-based implants with long-term antibacterial ability as well as better osteogenic activity is highly desirable for high quality implantation. Strontium (Sr) has been shown to be a significant element to favor bone growth by promoting new bone formation and inhibiting bone resorption. In this study, a novel duplex-treatment technique encompassing magnetron sputtering with micro-arc oxidation is utilized to fabricate porous Sr/Ag-containing TiO2 coatings loaded with different concentrations of Ag and Sr. All coatings are porous with pore size less than 5 µm. Ag is primarily distributed homogeneously inside the pores, and the concentrations of Ag in Sr/Ag-containing TiO2 coatings with low and high Ag contents are 0.40 at.% and 0.83 at.% respectively. We have demonstrated that this kind of coating displays long-lasting antibacterial ability even up to 28 d due to the incorporation of Ag. Further, Sr/Ag-containing TiO2 coatings with optimum Ag and Sr contents revealed good cytocompatibility, enhanced osteoblast spreading and osseointegration, which stemmed primarily from the synergistic effect exerted by the porous surface topography and the bioactive element Sr. However, this study has also identified, for the first time, that proper addition of Ag would further facilitate osteogenic effects. Besides, Sr may be able to alleviate the potential cytotoxic effect of excessive Ag. Thus, integration of optimum functional elements Ag and Sr into Ti-based implant materials would be expected to expedite osseointegration while simultaneously sustaining long-term antibacterial activity, which would provide new insights for relevant fundamental investigations and biomedical applications.
authors: Research Institute of Surface Engineering, Taiyuan University of Technology, 79 Yingze West Street, Taiyuan 030024, People's Republic of China.
authors: Xiaojing
authors: X
authors: He
authors: Xiangyu
authors: X
authors: Zhang
authors: Long
authors: L
authors: Bai
authors: Ruiqiang
authors: R
authors: Hang
authors: Xiaobo
authors: X
authors: Huang
authors: Lin
authors: L
authors: Qin
authors: Xiaohong
authors: X
authors: Yao
authors: Bin
authors: B
authors: Tang
mesh_terms: D016475:3T3 Cells; D008841:Actin Cytoskeleton / Q000378:metabolism; D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry*; D001672:Biocompatible Materials / Q000737:chemistry; D001862:Bone Resorption; D001842:Bone and Bones / Q000187:drug effects; D020099:Coated Materials, Biocompatible / Q000494:pharmacology; D003094:Collagen / Q000737:chemistry; D004926:Escherichia coli; D006801:Humans; D051379:Mice; D016348:Osseointegration; D010006:Osteoblasts / Q000166:cytology / Q000378:metabolism; D010012:Osteogenesis; D016062:Porosity; D019736:Prostheses and Implants; D012834:Silver / Q000737:chemistry; D013211:Staphylococcus aureus; D013324:Strontium / Q000737:chemistry; D013499:Surface Properties; D014025:Titanium / Q000737:chemistry*
chemical_list: D000900:Anti-Bacterial Agents; D001672:Biocompatible Materials; D020099:Coated Materials, Biocompatible; C009495:titanium dioxide; D012834:Silver; D003094:Collagen; D014025:Titanium; D013324:Strontium