title: Frontotemporal dementia: from molecular mechanisms to therapy.
abstract: Frontotemporal dementia (FTD) is a heterogeneous clinical syndrome characterized by frontotemporal lobar degeneration (FTLD). Neuropathologically, FTLD is characterized by abnormal protein deposits and almost all cases can now be classified into three major molecular subgroups based on specific accumulating proteins with the most common being FTLD-tau and FTLD-TDP (accounting for ~40% and 50%, respectively) and FTLD-FET (accounting for ~5-10%). In this special issue, the molecular and genetic basics as well as clinical approaches and therapeutics are reviewed in a series of articles. This article is part of the Frontotemporal Dementia special issue.
authors: BioMedical Center (BMC), Biochemistry, Ludwig-Maximilians-University Munich, Munich, Germany.|German Center for Neurodegenerative Diseases (DZNE) Munich, Munich, Germany.|Munich Cluster for Systems Neurology (SyNergy), Munich, Germany.
authors: Christian
authors: C
authors: Haass
authors: Department for Neuropathology, University Hospital of Tübingen, Tübingen, Germany.|German Center for Neurodegenerative Diseases (DZNE) Tübingen, Tübingen, Germany.
authors: Manuela
authors: M
authors: Neumann
mesh_terms: D057180:Frontotemporal Dementia / Q000235:genetics* / Q000628:therapy*; D006801:Humans; D009154:Mutation; D016875:tau Proteins / Q000378:metabolism
chemical_list: D016875:tau Proteins