title: Antiproliferative Effects of Modified Bioflavonoid in Ex Vivo Model.
abstract: We studied the effect of modified bioflavonoid and reference drug quercetin dihydrate on proliferation of mononuclears triggered by T- and B-cell mitogens. Lymphocytes were in vivo pretreated with the examined agents followed by their explantation and in vitro activation with T- and B-cell mitogens in cell culture. Intraperitoneal injection of modified bioflavonoid and quercetin dihydrate produced a dose-dependent inhibition of proliferation of the in vitroactivated splenocytes; modified bioflavonoid demonstrated higher antiproliferative activity.
authors: Department of Pharmacology, N. I. Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation, Moscow, Russia.
authors: D Z
authors: DZ
authors: Albegova
authors: Department of Pharmacology, N. I. Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation, Moscow, Russia.
authors: O V
authors: OV
authors: Kamkina
authors: N. I. Ul'yanov Chuvash State University, Cheboksary, Chuvash Republic, Russia.
authors: S I
authors: SI
authors: Pavlova
authors: North Ossetian State Medical Academy, Ministry of Health of Russia, Vladikavkaz, The Republic of North Ossetia-Alania, Russia. bigbeaver-90@mail.ru.
authors: Zh K
authors: ZhK
authors: Albegova
authors: Department of Pharmacology, N. I. Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation, Moscow, Russia.
authors: O S
authors: OS
authors: Laptev
authors: Department of Pharmacology, N. I. Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation, Moscow, Russia.
authors: I G
authors: IG
authors: Kozlov
mesh_terms: D000818:Animals; D049109:Cell Proliferation / Q000187:drug effects; D005419:Flavonoids / Q000494:pharmacology*; D007166:Immunosuppressive Agents / Q000494:pharmacology*; D008214:Lymphocytes / Q000166:cytology / Q000187:drug effects; D051379:Mice; D008807:Mice, Inbred BALB C; D008934:Mitogens / Q000494:pharmacology
chemical_list: D005419:Flavonoids; D007166:Immunosuppressive Agents; D008934:Mitogens
keywords: activation; flavonoids; immunosuppressants; mice; proliferation