title: [Transcranial doppler in sickle cell disease (SCD) in Malagasy children].
abstract: BACKGROUND
  Transcranial Doppler is an effective diagnostic tool to detect sickle cell children at risk for stroke.
  
  
  METHODS
  We conducted a cross-sectional descriptive study of Malagasy children aged between 24 months and 15 years (group 1: 57 sickle cell diseases, group 2: 43 controls) to assess the cerebral artery velocimetry in the patient population. Transcranial doppler ultrasound with analysis of cerebral blood flow was performed in children of both groups.
  
  
  RESULTS
  In subjects with sickle cell disease, the mean velocity (MV) in the middle cerebral artery was 100.9 ± 26.8 cm/s, pulsatility index (PI) was 0.73 ± 0.20, the difference between the right and left middle cerebral artery (MCA) was 19.8 ± 21.5 cm/s, anterior cerebral artery/middle cerebral artery flow velocity ratio (ACA / MCA) was 0.7 ± 0.2. In children without sickle cell disease, MV: 80.6 ± 19.3 cm/s, IP: 0.79 ± 0.14, ACMr: 17 ± 20.1 cm/s, ACA/ACM: 0,8 ± 0,2. The velocity in children with sickle cell disease was higher than in the control group. Velocities were correlated with hemoglobin and age but not with sex and mean corpuscular volume.
  
  
  CONCLUSIONS
  Cerebral Circulation Speeds are higher in children with sickle cell disease and are influenced by hemoglobin levels and age.
authors: AService Imagerie Médicale, Centre Hospitalier Universitaire d'Antsiranana, Madagascar.
authors: Nicolas Fanantenana
authors: NF
authors: Herinirina
authors: Service Imagerie Médicale, Centre Hospitalier Universitaire Joseph Ravoahangy Andrianavalona, Antananarivo, Madagascar.
authors: Lova Hasina Ny Ony Narindra
authors: LH
authors: Rajaonarison
authors: Service Imagerie Médicale, Centre Hospitalier Universitaire de Toamasina, Madagascar.
authors: Andry Roussel
authors: AR
authors: Herijoelison
authors: Service Hématologie et Biologie, Centre Hospitalier Universitaire Joseph Ravoahangy Andrianavalona, Antananarivo, Madagascar.
authors: Olivat Aimée Alson
authors: OA
authors: Rakoto
authors: Service Imagerie Médicale, Centre Hospitalier Universitaire de Toamasina, Madagascar.
authors: Ahmad
authors: A
authors: Ahmad
mesh_terms: D000293:Adolescent; D000367:Age Factors; D000755:Anemia, Sickle Cell / Q000000981:diagnostic imaging*; D001783:Blood Flow Velocity; D002536:Cerebral Arteries / Q000000981:diagnostic imaging; D002560:Cerebrovascular Circulation; D002648:Child; D002675:Child, Preschool; D003430:Cross-Sectional Studies; D005260:Female; D006454:Hemoglobins / Q000378:metabolism; D006801:Humans; D008297:Male; D017585:Ultrasonography, Doppler, Transcranial / Q000379:methods*
chemical_list: D006454:Hemoglobins
keywords: Cerebrovascular accident; child; sickle cell disease; transcranial Doppler