title: Analgesic efficacy of oral firocoxib in ovariohysterectomized cats.
abstract: The postoperative analgesic effects of firocoxib in ovariohysterectomized cats were observed. Twenty-four cats were divided into 3 groups: control (no medicine), firocoxib-1 (1 mg/kg/day) and firocoxib-3 (3 mg/kg/day). Colorado pain scale scores (CPSS), composite pain scores (CPS), and buccal mucosal bleeding times (BMBT) were recorded in blinded fashion before induction and 2, 5, 8, 24, 30, and 48 h post-operation. The average CPSS (mean ± SEM) over 2 to 48 h post-operation in firocoxib-3 (0.4 ± 0.1) was significantly lower than that of the control (0.7 ± 0.2;p= 0.004), but that of firocoxib-1 (0.5 ± 0.2) was not different from that of the control (p= 0.40). The mean CPS of firocoxib-3 was significantly lower than that of the control at 24 h post-operation (p= 0.04); nonetheless, there was no significant difference in mean CPS between firocoxib-1 and control groups at all intervals. BMBT and body temperature were within normal limits in all groups. However, reversible azotemia was identified in two firocoxib-3 cats at 72 h post-operation. One firocoxib-3 cat vomited once at 48 h post-operation. In conclusion, firocoxib-3 is helpful for postoperative pain control in cats; however, gastrointestinal irritation and renal function side effects may occur.
authors: Department of Companion Animal Clinical Sciences, Faculty of Veterinary Medicine, Kasetsart University, Bangkok 10900, Thailand.
authors: Prangtip
authors: P
authors: Phuwapattanachart
authors: Department of Companion Animal Clinical Sciences, Faculty of Veterinary Medicine, Kasetsart University, Bangkok 10900, Thailand.
authors: Naris
authors: N
authors: Thengchaisri
mesh_terms: D015107:4-Butyrolactone / Q000008:administration & dosage / Q000031:analogs & derivatives*; D000284:Administration, Oral; D000698:Analgesia / Q000379:methods / Q000662:veterinary*; D000700:Analgesics / Q000008:administration & dosage; D000818:Animals; D002415:Cats; D005260:Female; D007044:Hysterectomy / Q000662:veterinary*; D010052:Ovariectomy / Q000662:veterinary*; D010147:Pain Measurement / Q000662:veterinary; D013450:Sulfones / Q000008:administration & dosage
chemical_list: D000700:Analgesics; D013450:Sulfones; D015107:4-Butyrolactone; C487384:firocoxib
keywords: analgesia; cats; cyclooxygenase; firocoxib; ovariohysterectomy