title: Systems metabolic engineering of Escherichia coli for the heterologous production of high value molecules-a veteran at new shores.
abstract: For more than fifty years, Escherichia coli has represented a remarkable success story in industrial biotechnology. Traditionally known as a producer of l-amino acids, E. coli has also entered the precious market of high-value molecules and is becoming a flexible, efficient production platform for various therapeutics, pre-biotics, nutraceuticals and pigments. This tremendous progress is enabled by systems metabolic engineering concepts that integrate systems biology and synthetic biology into the design and engineering of powerful E. coli cell factories.
authors: Institute of Systems Biotechnology, Universität des Saarlandes, Germany.
authors: Judith
authors: J
authors: Becker
authors: Institute of Systems Biotechnology, Universität des Saarlandes, Germany. Electronic address: christoph.wittmann@uni-saarland.de.
authors: Christoph
authors: C
authors: Wittmann
mesh_terms: D000596:Amino Acids / Q000378:metabolism; D000818:Animals; D001688:Biological Products / Q000737:chemistry / Q000378:metabolism*; D001709:Biotechnology / Q000379:methods / Q000639:trends*; D004926:Escherichia coli / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D060847:Metabolic Engineering / Q000379:methods* / Q000639:trends; D058615:Synthetic Biology / Q000379:methods / Q000639:trends; D049490:Systems Biology / Q000379:methods* / Q000639:trends
chemical_list: D000596:Amino Acids; D001688:Biological Products