title: Antimicrobial susceptibility of Brachyspira hyodysenteriae in Switzerland.
abstract: Brachyspira (B.) hyodysenteriae is the causative agent of swine dysentery (SD), a severe mucohaemorrhagic diarrheal disease in pigs worldwide. So far, the antimicrobial susceptibility patterns of B. hyodysenteriae in Switzerland have not been investigated. Therefore, a panel of 30 porcine B. hyodysenteriae isolates were tested against 6 antimicrobial agents by using the VetMIC Brachy panel, a broth microdilution test. Tiamulin and valnemulin showed high antimicrobial activity inhibiting all isolates at low concentrations. The susceptibility testing of doxycycline revealed values from ≤0.25 μg/ ml (47%) to 2 μg/ml (10%). The MIC values of lincomycin ranged between ≤0.5 μg/ml (30%) and 32 μg/ml (43%). For tylosin, 57% of the isolates could not be inhibited at the highest concentration of ≥128 μg/ml. The MIC values for tylvalosin were between ≤0.25 μg/ml (10%) and 8 μg/ml (20%). These findings reveal Switzerland's favourable situation compared to other European countries. Above all, tiamulin and valnemulin are still effective antimicrobial agents and can be further used for the treatment of SD.
authors: Institute of Veterinary Bacteriology, Vetsuisse Faculty, University of Zurich, Switzerland.
authors: C
authors: C
authors: Kirchgässner
authors: Institute of Veterinary Bacteriology, Vetsuisse Faculty, University of Zurich, Switzerland.
authors: S
authors: S
authors: Schmitt
authors: Institute of Veterinary Bacteriology, Vetsuisse Faculty, University of Zurich, Switzerland.
authors: A
authors: A
authors: Borgström
authors: Institute of Veterinary Bacteriology, Vetsuisse Faculty, University of Zurich, Switzerland.
authors: M M
authors: MM
authors: Wittenbrink
mesh_terms: D000818:Animals; D000890:Anti-Infective Agents / Q000494:pharmacology*; D017401:Brachyspira hyodysenteriae / Q000187:drug effects* / Q000302:isolation & purification; D016905:Gram-Negative Bacterial Infections / Q000382:microbiology / Q000662:veterinary*; D008826:Microbial Sensitivity Tests; D013552:Swine; D013553:Swine Diseases / Q000382:microbiology*; D013557:Switzerland
chemical_list: D000890:Anti-Infective Agents
keywords: Brachyspira hyodysenteriae; Empfindlichkeitsprüfung; Resistenz; Schweinedysenterie; Schweiz; Switzerland; antimicrobial susceptibility testing; resistance; swine dysentery