title: Validation of the laryngopharyngeal reflux color and texture recognition compared to pH-probe monitoring.
abstract: The objective of this study was to determine the validity of our laryngopharyngeal reflux (LPR) diagnostic system from our previous study (Witt et al.) against the results of a standard pH probe monitoring. We hypothesized that subjects with abnormal pH probe results demonstrate color and texture abnormalities that would be classified as LPR according to artificial neural network (ANN) analysis.
  
  
  
  Retrospective analysis.
  
  
  
  Eighty-two subjects, including 18 pH-positive, 11 pH-negative, and 53 control subjects were tested for LPR through multichannel intraluminal impedance 24-hour pH (MII-24pH) monitoring. Laryngoscopic images of all subjects were obtained. The hue and texture values of seven areas of interest, including true vocal folds, false vocal folds, arytenoids, and interarytenoid, were quantified using a hue calculation and two-dimensional Gabor filtering. These served as inputs for the ANN. This was used to classify images through pattern recognition, and a receiver operating characteristic (ROC) analysis was performed to determine the effectiveness of the diagnosis.
  
  
  
  Classification accuracy for the combined hue and texture was 87.40%, with an area under the ROC curve of 0.910.
  
  
  
  Although a previous study conducted classification based on RFS, this study suggests that color and texture analysis may be used to classify images based on the results of pH probing, a more objective approach for diagnosis. Additional studies should include more subjects to produce an even more accurate reading, and will use the color/texture analysis tool to test and confirm this application in a clinical setting.
  
  
  
  3B. Laryngoscope, 127:665-670, 2017.
authors: Department of Otorhinolaryngology -Head and Neck Surgery, Peking University Third Hospital, Beijing, People's Republic of China.
authors: Chen
authors: C
authors: Du
authors: Department of Surgery, Division of Otolaryngology-Head and Neck Surgery, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, U.S.A.
authors: Jehad
authors: J
authors: Al-Ramahi
authors: Department of Surgery, Division of Otolaryngology-Head and Neck Surgery, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, U.S.A.
authors: Qingsong
authors: Q
authors: Liu
authors: Department of Otorhinolaryngology -Head and Neck Surgery, Peking University Third Hospital, Beijing, People's Republic of China.
authors: Yan
authors: Y
authors: Yan
authors: Department of Surgery, Division of Otolaryngology-Head and Neck Surgery, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, U.S.A.
authors: Jack
authors: J
authors: Jiang
mesh_terms: D016022:Case-Control Studies; D002681:China; D003116:Color; D017097:Electric Impedance / Q000145:classification*; D050782:Esophageal pH Monitoring / Q000379:methods*; D005189:False Positive Reactions; D005260:Female; D006785:Hospitals, University; D006801:Humans; D007827:Laryngitis / Q000175:diagnosis* / Q000209:etiology / Q000473:pathology; D057045:Laryngopharyngeal Reflux / Q000150:complications / Q000175:diagnosis* / Q000473:pathology; D007828:Laryngoscopy / Q000379:methods; D008297:Male; D008875:Middle Aged; D012372:ROC Curve; D012189:Retrospective Studies
keywords: Laryngitis; color analysis; laryngopharyngeal reflux; texture analysis