title: Association of Interleukin 10 Gene Polymorphisms with Autoimmune Thyroid Disease: Meta-Analysis.
abstract: The aim of this study was to perform a meta-analysis of eligible studies and to derive a precise estimate of the association between interleukin 10 (IL10) polymorphisms and susceptibility to autoimmune thyroid disease (AITD). Meta-analyses were conducted on the associations between AITD and the -1082 G/A (rs1800896), -819 C/T (rs1800871) and -592 C/A (rs1800872) polymorphisms in IL10, and the haplotype of these polymorphisms and AITD. A total of 2903 AITD patients and 3060 controls in 10 eligible studies were included in the meta-analysis. This meta-analysis showed significant associations between IL10 at the -1082 G allele and overall AITD (OR: 1.44, 95% CI 1.13-1.82, P = 0.003), but no association between the IL10 -592 C allele and the -819 C allele and AITD. Subgroup studies demonstrated significant associations between the -1082 G allele and susceptibility to Graves' disease. Ethnicity-specific meta-analysis revealed significant associations between the -1082 G allele and AITD susceptibility in Asian populations; however, in Middle Eastern populations, no association was evident. Meta-analysis of the IL10 haplotype revealed an association between the ATA haplotype and AITD (OR: 1.17, 95% CI 1.00-1.36, P = 0.04). Meta-analysis demonstrates that the IL10 polymorphisms are associated with susceptibility to AITD.
authors: Division of Rheumatology, Department of Internal Medicine, Korea University Guro Hospital, Seoul, Korea.
authors: J H
authors: JH
authors: Jung
authors: Division of Rheumatology, Department of Internal Medicine, Korea University Guro Hospital, Seoul, Korea.
authors: G G
authors: GG
authors: Song
authors: Division of Rheumatology, Department of Internal Medicine, Korea University Guro Hospital, Seoul, Korea.
authors: J-H
authors: JH
authors: Kim
authors: Division of Rheumatology, Department of Internal Medicine, Korea University Ansan Hospital, Ansan-si, Gyeonggi-do, Korea. csjmd888@korea.ac.kr.
authors: S J
authors: SJ
authors: Choi
mesh_terms: D000483:Alleles; D044466:Asian People; D004660:Encephalitis / Q000175:diagnosis / Q000208:ethnology / Q000235:genetics* / Q000276:immunology; D015870:Gene Expression; D020022:Genetic Predisposition to Disease; D006111:Graves Disease / Q000175:diagnosis / Q000208:ethnology / Q000235:genetics* / Q000276:immunology; D006239:Haplotypes; D050031:Hashimoto Disease / Q000175:diagnosis / Q000208:ethnology / Q000235:genetics* / Q000276:immunology; D006801:Humans; D016753:Interleukin-10 / Q000235:genetics* / Q000276:immunology; D020641:Polymorphism, Single Nucleotide; D013967:Thyroiditis, Autoimmune / Q000175:diagnosis / Q000208:ethnology / Q000235:genetics* / Q000276:immunology; D044465:White People
chemical_list: C508609:IL10 protein, human; D016753:Interleukin-10