title: Post-bronchiolitis wheezing is associated with toll-like receptor 9 rs187084 gene polymorphism.
abstract: Innate immunity receptors play a critical role in host defence, as well as in allergy and asthma. The aim of this exploratory study was to evaluate whether there are associations between TLR7 rs179008, TLR8 rs2407992, TLR9 rs187084 or TLR10 rs4129009 polymorphisms and viral findings, clinical characteristics or subsequent wheezing in infants with bronchiolitis. In all, 135 full-term infants were hospitalized for bronchiolitis at age less than 6 months: 129 of them were followed-up until the age of 1.5 years. The outcome measures were repeated wheezing, use of inhaled corticosteroids, atopic dermatitis during the first 1.5 years of life and total serum immunoglobulin E (IgE). There were no significant associations between the genotypes or allele frequencies of TLR7 rs179008, TLR8 rs2407992, TLR9 rs187084 or TLR10 rs4129009 polymorphisms and clinical characteristics or the severity of bronchiolitis during hospitalization. During follow-up, repeated wheezing was more common in children with TLR9 rs187084 variant genotype CC (30.5%) than in children with TLR9 wild-type genotype TT (12.2%) (p = 0.02, aOR 2.73, 95% CI 1.02-7.29). The TLR10 rs4129009 minor allele G was associated with elevated total serum IgE. TLR9 rs187084 gene polymorphism may be associated with post-bronchiolitis wheezing, and TLR10 rs4129009 gene polymorphism may be associated with atopy.
authors: Department of Pediatrics, Seinäjoki Central Hospital, Seinäjoki, Finland.
authors: Kirsi
authors: K
authors: Nuolivirta
authors: Center for Child Health Research, Tampere University and University Hospital, Tampere, Finland.
authors: Sari
authors: S
authors: Törmänen
authors: Department of Medical Microbiology and Immunology, University of Turku, Turku, Finland.
authors: Johanna
authors: J
authors: Teräsjärvi
authors: Department of Medical Microbiology and Immunology, University of Turku, Turku, Finland.
authors: Juho
authors: J
authors: Vuononvirta
authors: Center for Child Health Research, Tampere University and University Hospital, Tampere, Finland.
authors: Petri
authors: P
authors: Koponen
authors: Center for Child Health Research, Tampere University and University Hospital, Tampere, Finland.
authors: Matti
authors: M
authors: Korppi
authors: Center for Child Health Research, Tampere University and University Hospital, Tampere, Finland.
authors: Merja
authors: M
authors: Helminen
authors: Department of Pediatrics and Adolescent Medicine, Turku University Hospital and Child and Youth Research Institute, University of Turku, Turku, Finland.
authors: Ville
authors: V
authors: Peltola
authors: Department of Medical Microbiology and Immunology, University of Turku, Turku, Finland.|Department of Medical Microbiology, Capital Medical University, Beijing, China.
authors: Qiushui
authors: Q
authors: He
mesh_terms: D001988:Bronchiolitis / Q000235:genetics*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D008297:Male; D011110:Polymorphism, Genetic; D012135:Respiratory Sounds / Q000235:genetics*; D051217:Toll-Like Receptor 9 / Q000235:genetics*
chemical_list: C495371:TLR9 protein, human; D051217:Toll-Like Receptor 9