title: Pauci-immune glomerulonephritis in a captive chimpanzee (Pan troglodytes), and a review of spontaneous cases in animals.
abstract: Crescentic glomeruli are the hallmark finding in rapidly progressive glomerulonephritis (RPGN) and are characterized by disruption and proliferation of the glomerular capsule and an influx of cells into Bowman's space. Pauci-immune-type RPGN is identified by a lack of immunoglobulins and immune complexes in the glomerular basement membrane.
  
  
  
  Complete necropsy and histology were performed on the affected chimpanzee. Electron microscopy was performed on kidney sections. A search of the literature was performed to identify spontaneous RPGN in animals.
  
  
  
  We report a case of crescentic glomerulonephritis of the pauci-immune-type in a hepatitis C virus-infected 28-year-old male chimpanzee (Pan troglodytes) who was humanely euthanized for a cardiac-related decline in health.
  
  
  
  To our knowledge, this is the first report describing pauci-immune crescentic glomerulonephritis in a non-human primate.
authors: Southwest National Primate Research Center, Texas Biomedical Research Institute, San Antonio, TX, USA.|Department of Comparative Medicine, University of Washington, Seattle, WA, USA.
authors: Lauren E
authors: LE
authors: Neidig
authors: Southwest National Primate Research Center, Texas Biomedical Research Institute, San Antonio, TX, USA.
authors: Michael A
authors: MA
authors: Owston
authors: Veterinary Pathology Services, Joint Pathology Center, Silver Spring, MD, USA.
authors: Erin
authors: E
authors: Ball
authors: Southwest National Primate Research Center, Texas Biomedical Research Institute, San Antonio, TX, USA.
authors: Edward J
authors: EJ
authors: Dick
mesh_terms: D000818:Animals; D000829:Animals, Domestic; D000836:Animals, Zoo; D018420:Ape Diseases / Q000175:diagnosis / Q000473:pathology; D005921:Glomerulonephritis / Q000145:classification / Q000175:diagnosis / Q000473:pathology / Q000662:veterinary*; D008297:Male; D002679:Pan troglodytes
keywords: chimpanzee ; crescentic glomerulonephritis; non-human primate; pauci-immune; rapidly progressive glomerulonephritis