title: Arterial and Ventricular Elastance and Ventriculo-arterial Coupling in Asthmatic Children.
abstract: OBJECTIVE
  To compare arterial and ventricular end-systolic elastance and ventriculo-arterial coupling between asthma and healthy children and correlate these all three parameters with pulmonary function tests in subjects with asthma.
  
  
  METHODS
  Across-sectional analytical study.
  
  
  METHODS
  Department of Pediatrics, Bozok University Medical Faculty,Yozgat, Turkey, from January 2012 to November 2014.
  
  
  METHODS
  Transthoracic and Doppler echocardiography and pulmonary function tests in patients with asthma aged 7 - 12 years and control subjects. Forty stable asthma patients on prophylactic inhaled corticosteroids and 97 healthy subjects were investigated. Both groups were matched for age, gender, blood pressure, heart rate, body surface area, echocardiographic parameters and pulmonary function tests.
  
  
  RESULTS
  There was no difference regarding left ventricular elastance at end-systole derived by single beat/body surface area (Ees(sb)/BSA) between asthmatic patients and healthy children (2.59 ±1.29 mmHg/ml/m2, 2.43 ±1.28 mmHg/ml/m2 respectively, p=0.504), arterial elastance/BSA(Ea/BSA) (2.10 ±0.97, 1.75 ±0.89 respectively, p=0.041), and ventriculoarterial coupling (VAC) (0.83 ±0.13, 0.74 ±0.13, respectively, p < 0.001) were higher in asthmatic group than controls. There was no correlation between Ea, Ees (sb), VAC and pulmonary function tests.
  
  
  CONCLUSIONS
  Arterial elastance increase and stiffness decrease in asthmatic patients. This may be due to using prophylactic inhaled corticosteroids. Using inhaled corticosteroids have protective effects against atherosclerosis. As a result of this higher arterial elastance, asthmatic children had higher VAC resulting in less efficient cardiovascular function.
authors: Department of Pediatrics, Bozok University Medical Faculty, Yozgat, Turkey.
authors: Esra Akyuz
authors: EA
authors: Ozkan
authors: Department of Pediatric Cardiology, Bozok University Medical Faculty, Yozgat, Turkey.
authors: Hashem E
authors: HE
authors: Khosroshahi
authors: Department of Public Health, Bozok University Medical Faculty, Yozgat, Turkey.
authors: Mahmut
authors: M
authors: Kilic
authors: Department of Pediatrics, Bozok University Medical Faculty, Yozgat, Turkey.
authors: U Aliye
authors: UA
authors: Gecit
authors: Department of Pediatrics, Bozok University Medical Faculty, Yozgat, Turkey.
authors: Esra
authors: E
authors: Domur
authors: Department of Pediatrics, Bozok University Medical Faculty, Yozgat, Turkey.
authors: Perihan
authors: P
authors: Beysel
mesh_terms: D001158:Arteries / Q000000981:diagnostic imaging / Q000502:physiology / Q000503:physiopathology*; D001249:Asthma / Q000503:physiopathology*; D016022:Case-Control Studies; D002648:Child; D003430:Cross-Sectional Studies; D015150:Echocardiography, Doppler / Q000379:methods*; D005260:Female; D006352:Heart Ventricles / Q000000981:diagnostic imaging; D006801:Humans; D008297:Male; D013599:Systole; D014421:Turkey; D059289:Vascular Stiffness / Q000502:physiology*; D016277:Ventricular Function, Left / Q000502:physiology*