title: Pharmacogenomics in Psychiatric Practice.
abstract: Pharmacogenomic testing in psychiatry is becoming an established clinical procedure. Several vendors provide clinical interpretation of combinatorial pharmacogenomic testing of gene variants that have documented predictive implications regarding either pharmacologic response or adverse effects in depression and other psychiatric conditions. Such gene profiles have demonstrated improvements in outcome in depression, and reduction of cost of care of patients with inadequate clinical response. Additionally, several new gene variants are being studied to predict specific response in individuals. Many of these genes have demonstrated a role in the pathophysiology of depression or specific depressive symptoms. This article reviews the current state-of-the-art application of psychiatric pharmacogenomics.
authors: Mood Disorders Research Program, Department of Psychiatry and Behavioral Sciences, University of Louisville HealthCare OutPatient Center, University of Louisville School of Medicine, 401 East Chestnut Street, Suite 610, Louisville, KY 40202, USA. Electronic address: rselma01@louisville.edu.
authors: Rif S
authors: RS
authors: El-Mallakh
authors: Department of Psychiatry and Behavioral Sciences, University of Louisville HealthCare OutPatient Center, University of Louisville Hospital, University of Louisville School of Medicine, 401 East Chestnut Street, Suite 610, Louisville, KY 40202, USA.
authors: R Jeannie
authors: RJ
authors: Roberts
authors: Graduate Psychiatric-Mental Health Nursing Program, University of Kentucky College of Nursing, University of Kentucky, 547 College of Nursing Building, Lexington, KY 40536-0232, USA.
authors: Peggy L
authors: PL
authors: El-Mallakh
authors: Graduate Psychiatric-Mental Health Nursing Program, University of Kentucky College of Nursing, University of Kentucky, 547 College of Nursing Building, Lexington, KY 40536-0232, USA.
authors: Lillian Jan
authors: LJ
authors: Findlay
authors: PGXL Laboratories, Department of Pathology, University of Louisville School of Medicine, University of Louisville, 201 East Jefferson Street, Suite 309, Louisville, KY 40202, USA.
authors: Kristen K
authors: KK
authors: Reynolds
mesh_terms: D003863:Depression / Q000188:drug therapy / Q000235:genetics; D064420:Drug-Related Side Effects and Adverse Reactions / Q000235:genetics*; D005820:Genetic Testing; D006801:Humans; D001523:Mental Disorders / Q000188:drug therapy* / Q000235:genetics*; D010597:Pharmacogenetics; D011570:Psychiatry
keywords: 2D6; Antidepressants; Antipsychotics; CYP2D6; OPRM1; Pharmacogenomic testing; Psychiatric pharmacogenomics; SLC6A4