title: Sebaceous mantleoma (mantle adenoma): reappraisal of the myth of the problematic benign neoplasm with sebaceous mantle differentiation.
abstract: Few cases of a true benign neoplasm with sebaceous mantle differentiation have been reported, and little is known about this tumor. Herein, we present a rare case of the neoplasm called sebaceous mantleoma, along with a comparison of the histology and immunoprofile with those of normal sebaceous mantles. A pedunculated polyp occurred on the scalp of a 51-year-old woman. Histopathologically, the tumor showed lobulated epithelial-mesenchymal units that were separated from the normal dermis by clefts. The lesion was composed of cords and columns of basaloid cells containing a few mature sebocytes, with a focal connection to infundibulocystic structures as well as dense fibrotic or fibromyxoid stroma. Immunohistochemically, androgen receptor, estrogen receptor, and CD117 were partially positive for the tumor, and CD8 (C8/144B) and epithelial membrane antigen were focally positive. Additionally, cytokeratin 20-positive Merkel cells were individually admixed in the tumor nests as well as in normal sebaceous mantles. This case report reveals the characteristic histology and immunoprofile of this problematic benign neoplasm and helps to understand this entity.
authors: Department of Diagnostic Pathology, Kainan Hospital, Aichi, Japan. vapour-trail@nifty.com.
authors: Keisuke
authors: K
authors: Goto
authors: Division of Dermatology, Nakao Clinic, Saga, Japan.
authors: Noriyuki
authors: N
authors: Misago
authors: Department of Plastic Surgery, Showa University Fujigaoka Hospital, Kanagawa, Japan.
authors: Noriyoshi
authors: N
authors: Sumiya
authors: Department of Pathology, Itabashi Central Medical Laboratory, Tokyo, Japan.
authors: Yukio
authors: Y
authors: Ishikawa
mesh_terms: D014408:Biomarkers, Tumor / Q000378:metabolism; D005260:Female; D006801:Humans; D053554:Keratin-20 / Q000378:metabolism; D008875:Middle Aged; D012626:Sebaceous Gland Neoplasms / Q000175:diagnosis* / Q000378:metabolism / Q000601:surgery; D012627:Sebaceous Glands / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D016896:Treatment Outcome
chemical_list: D014408:Biomarkers, Tumor; D053554:Keratin-20
keywords: mantle; mantle adenoma; mantleoma; sebaceous; skin tumor