title: Changes of four common non-infectious liver diseases for the hospitalized patients in Beijing 302 hospital from 2002 to 2013.
abstract: The implementation of a hepatitis B vaccination program in China has led to a significant decline in the prevalence and incidence of liver diseases secondary to hepatitis B virus over the past two decades. With recent changes in the economy and increases in average incomes in China during the same period, there has been a rapid rise in per capita alcohol consumption and an epidemic of obesity. We hypothesized that the burden of liver diseases in China has shifted from infectious to non-infectious etiologies. We retrospectively analyzed the data of 20,378 patients who were hospitalized in Beijing 302 hospital between 2002 and 2013. We found that the total admission rate secondary to alcoholic liver disease (ALD), non-alcoholic liver disease (NAFLD), autoimmune liver disease (AILD), and drug-induced liver injury (DILI) was 10.7%. ALD was the leading cause of inpatient hospitalization (3.9% of total admissions). The rate of inpatient admission for ALD, AILD, and DILI increased by 170%, 111%, and 107%, respectively during the study period. Chinese herbal medicine was the primary cause of DILI in our subjects. The burden of non-infectious liver diseases has increased over the last decade among hospitalized patients in a large tertiary hospital in China. The increase in the rate of admission for ALD and DILI from Chinese herbal medicine suggests that strategies to reduce harmful use of alcohol and increase awareness and education on the use of herbal medicine are needed.
authors: The Center for Non-infectious Liver Disease, Beijing 302 Hospital, Beijing, China.
authors: Binxia
authors: B
authors: Chang
authors: The Center for Non-infectious Liver Disease, Beijing 302 Hospital, Beijing, China.
authors: Baosen
authors: B
authors: Li
authors: The Center for Non-infectious Liver Disease, Beijing 302 Hospital, Beijing, China.
authors: Ang
authors: A
authors: Huang
authors: The Center for Non-infectious Liver Disease, Beijing 302 Hospital, Beijing, China.
authors: Ying
authors: Y
authors: Sun
authors: The Center for Non-infectious Liver Disease, Beijing 302 Hospital, Beijing, China.
authors: Guangju
authors: G
authors: Teng
authors: The Department of Medical Administration, Beijing 302 Hospital, Beijing, China.
authors: Xiaoxia
authors: X
authors: Wang
authors: Division of Gastroenterology and Hepatology, Department of Medicine, Indiana University School of Medicine, USA.
authors: Suthat
authors: S
authors: Liangpunsakul
authors: The Department of Medical Administration, Beijing 302 Hospital, Beijing, China. Electronic address: lijin302@hotmail.com.
authors: Jin
authors: J
authors: Li
authors: The Center for Non-infectious Liver Disease, Beijing 302 Hospital, Beijing, China. Electronic address: zszou302@163.com.
authors: Zhengsheng
authors: Z
authors: Zou
mesh_terms: D000328:Adult; D000368:Aged; D056486:Chemical and Drug Induced Liver Injury / Q000453:epidemiology*; D002681:China / Q000453:epidemiology; D005260:Female; D006760:Hospitalization / Q000639:trends*; D006801:Humans; D008107:Liver Diseases / Q000453:epidemiology*; D008108:Liver Diseases, Alcoholic / Q000453:epidemiology*; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D055815:Young Adult
keywords: Alcoholic liver disease; Autoimmune liver disease; Drug-induced liver injury; Non-alcoholic fatty liver disease; Non-infectious liver disease