title: Correlation of retinopathy with leukoaraiosis in patients with anterior circulation infarcts.
abstract: Although retinal and cerebral microvessels share similar embryological, anatomical and physiological characteristics, the correlation between retinopathy and leukoaraiosis (LA), a type of brain microvascular disease, is unclear. In the present study, the sample included 213 patients admitted to the department of neurology from January 2012 through October 2012. MRI and retinal photography were performed within 48hours of hospitalization, and patient demographics, comorbidities, preadmission medications and laboratory data were collected. MRI images were used to divide the patients into LA and non-LA groups. Using multivariate binary logistic regression, the effects of retinopathy on LA were investigated. Of the 213 patients enrolled, 168 were included in this study (LA, n=108; non-LA, n=60). Hypertension, coronary heart disease and carotid artery plaque were more common in the LA group, and these patients showed higher blood levels of C-reactive protein, homocysteine and triglycerides. The incidence of retinopathy was significantly increased in the LA group compared with the non-LA group, and there was a significant correlation between the severity of LA and incidence of retinopathy. Retinopathy is an independent risk factor for LA and can significantly increase the risk of LA when combined with age, coronary heart disease, C-reactive protein, carotid artery plaque or systolic pressure. Taken together, retinopathy is associated with LA in patients with anterior circulation infarcts. Retinopathy is an independent risk factor for LA and an increase the risk of LA, and thus facilitating the evaluation of LA.
authors: Department of Neurology, PLA Army General Hospital, No.5 Nan men Cang, Dongcheng District, Beijing 100700, China.
authors: Wei
authors: W
authors: Wei
authors: Department of Neurology, PLA Army General Hospital, No.5 Nan men Cang, Dongcheng District, Beijing 100700, China.
authors: Zhenxi
authors: Z
authors: Xia
authors: Department of Medical Affairs, General Hospital of Beijing Command PLA, Dongcheng District, Beijing, China.
authors: Hongyan
authors: H
authors: Gao
authors: Department of Neurology, PLA Army General Hospital, No.5 Nan men Cang, Dongcheng District, Beijing 100700, China.
authors: Jingjing
authors: J
authors: Gong
authors: Department of Neurology, TangshanWorker Hospital, Tangshan, China.
authors: Liping
authors: L
authors: Yan
authors: Department of Neurology, PLA Army General Hospital, No.5 Nan men Cang, Dongcheng District, Beijing 100700, China. Electronic address: huangyonghua002@sina.com.
authors: Yonghua
authors: Y
authors: Huang
authors: Department of Neurology, PLA Army General Hospital, No.5 Nan men Cang, Dongcheng District, Beijing 100700, China.
authors: Fei
authors: F
authors: Chen
authors: Department of Neurology, PLA Army General Hospital, No.5 Nan men Cang, Dongcheng District, Beijing 100700, China.
authors: Weiwei
authors: W
authors: Zhang
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood; D059345:Cerebral Small Vessel Diseases / Q000150:complications / Q000000981:diagnostic imaging; D005260:Female; D006801:Humans; D015994:Incidence; D020243:Infarction, Anterior Cerebral Artery / Q000150:complications / Q000000981:diagnostic imaging*; D049292:Leukoaraiosis / Q000000981:diagnostic imaging* / Q000209:etiology; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D015588:Observer Variation; D012164:Retinal Diseases / Q000000981:diagnostic imaging* / Q000209:etiology; D012307:Risk Factors
chemical_list: D015415:Biomarkers
keywords: Anterior circulation infarcts; Brain microvascular diseases; Leukoaraiosis; Retinopathy; Risk factors