title: Terapeutic importance of apoptosis pathways in pancreatic cancer.
abstract: Recent studies indicate the significant role of apoptosis and the genes that control it in the process of carcinogenesis. Apoptosis or programmed cell death is a complex process that controls cell proliferation and maintenance of accounting for the necessary balance in the body. Disturbances of apoptotic signalling pathways directly lead to the development and progression of cancer. This also applies to pancreatic cancer, which is characterized by poor prognosis and resistance to treatment. In recent years progress has been made concerning the complex pathways of apoptosis, which allowed the development of new therapeutic strategies. This article reviews current knowledge on apoptosis pathways and their role in treatment of pancreatic cancer.
authors: Department of Physiology Jagiellonian University Medical College; John Paul II Hospital, Krakow, Poland.
authors: Aldona
authors: A
authors: Olechowska-Jarząb
authors: Department of Physiology Jagiellonian University Medical College, Krakow, Poland. agata.ptak-belowska@uj.edu.pl.
authors: Agata
authors: A
authors: Ptak-Belowska
authors: Tomasz
authors: T
authors: Brzozowski
mesh_terms: D000970:Antineoplastic Agents / Q000494:pharmacology; D017209:Apoptosis / Q000187:drug effects* / Q000502:physiology; D006801:Humans; D010190:Pancreatic Neoplasms / Q000188:drug therapy* / Q000473:pathology*; D017382:Reactive Oxygen Species / Q000378:metabolism
chemical_list: D000970:Antineoplastic Agents; D017382:Reactive Oxygen Species
keywords: apoptosis; pancreatic cancer; treatment