title: Time-course gene expression data on the transcriptional effects of Aminaphtone on ECV304 endothelial cells.
abstract: We previously showed that Aminaphtone, a drug used in the treatment of chronic venous insufficiency, modulates several vasoactive factors, such as endothelin-1 and adhesion molecules. Here, we provide data of time-course experiments about the effects of Aminaphtone on gene expression at the genome-wide level in human endothelial cells undergoing cytokine stimulation in vitro. ECV-304 endothelial cells were incubated with interleukin-1β (IL-1β) in the presence or absence of Aminaphtone for 1, 3, and 6 h. Gene expression profiles were analyzed by microarray. This article contains complete data on the genes significantly modulated by the drug over time. The data are supplemental to our original research article reporting detailed analysis of the actions of Aminaphtone on IL-1β stimulated endothelial cells at the molecular level, "Gene expression profiling reveals novel protective effects of Aminaphtone on ECV304 endothelial cells" (Salazar et al., 2016) [1].
authors: Referral Centre for Systemic Autoimmune Diseases, University of Milan and Fondazione IRCCS Ca׳ Granda Ospedale Maggiore Policlinico, Milano, Italy.
authors: Giulia
authors: G
authors: Salazar
authors: Referral Centre for Systemic Autoimmune Diseases, University of Milan and Fondazione IRCCS Ca׳ Granda Ospedale Maggiore Policlinico, Milano, Italy.
authors: Chiara
authors: C
authors: Bellocchi
authors: Laboratory of Preclinical and Translational Research, IRCCS-CROB, Referral Cancer Centre of Basilicata, Rionero in Vulture, Italy.
authors: Katia
authors: K
authors: Todoerti
authors: Laboratory of Immunology and Functional Genomics, Centro Cardiologico Monzino IRCCS, Milano, Italy.
authors: Federica
authors: F
authors: Saporiti
authors: Laboratory of Immunology and Functional Genomics, Centro Cardiologico Monzino IRCCS, Milano, Italy.
authors: Luca
authors: L
authors: Piacentini
authors: Referral Centre for Systemic Autoimmune Diseases, University of Milan and Fondazione IRCCS Ca׳ Granda Ospedale Maggiore Policlinico, Milano, Italy.
authors: Raffaella
authors: R
authors: Scorza
authors: Laboratory of Immunology and Functional Genomics, Centro Cardiologico Monzino IRCCS, Milano, Italy.
authors: Gualtiero I
authors: GI
authors: Colombo
keywords: Aminaphtone (PubChem CID: 84621); Endothelial cells; Inflammation; Transcriptome; Vasoactive drug