title: Evaluation of the Antioxidative, Antibacterial, and Anti-Inflammatory Effects of the Aloe Fermentation Supernatant Containing Lactobacillus plantarum HM218749.1.
abstract: Little work is done to develop Aloe vera (AV) using probiotics. To explore the potential benefits, the antioxidant effects and the antibacterial effects on foodborne pathogens of Aloe fermentation supernatant were evaluated in vitro. Our results indicated that the Aloe fermentation supernatant fermented by Lactobacillus plantarum HM218749.1 had very strong scavenging capacities of the DPPH (86%), O2 (•-) (85%), (•)OH (76%), and Fe(2+) chelation (82%) and reducing powers (242.5 mg/L), and the inhibition zones for Salmonella typhimurium, Salmonella enteritidis, Shigella flexneri, Escherichia coli, Listeria monocytogenes, S. dysenteriae 301, Staphylococcus aureus Cowan1, and Propionibacterium acnes were 16, 15, 19, 20, 21, 20, and 27 mm. Moreover, the low concentration of Aloe fermentation supernatant had significantly reduced the production of IL-1β, TNF-α, and IL-6 in both mRNA and protein levels (P < 0.01). Therefore, the Aloe fermentation supernatant can be used as functional beverage or cosmetic ingredients to guard human intestinal health, delaying senescence, and prevent chronic diseases.
authors: Institute of Translational Medicine, Nanchang University, Nanchang, Jiangxi 330031, China.
authors: Meixiu
authors: 0000-0001-8747-6877
authors: M
authors: Jiang
authors: Institute of Translational Medicine, Nanchang University, Nanchang, Jiangxi 330031, China.
authors: Kan
authors: K
authors: Deng
authors: Jiangxi Cancer Hospital, Nanchang 330045, China.
authors: Chunling
authors: C
authors: Jiang
authors: Department of Basic Medical Science, School of Medicine, University of Missouri Kansas City, Kansas City, MO 64108, USA.
authors: Mingui
authors: M
authors: Fu
authors: College of Forestry, Jiangxi Agriculture University, Nanchang 330045, China.
authors: Chunlan
authors: C
authors: Guo
authors: Institute of Translational Medicine, Nanchang University, Nanchang, Jiangxi 330031, China.
authors: Xiaolei
authors: X
authors: Wang
authors: Institute of Translational Medicine, Nanchang University, Nanchang, Jiangxi 330031, China.
authors: Xin
authors: X
authors: Wang
authors: Institute of Translational Medicine, Nanchang University, Nanchang, Jiangxi 330031, China.
authors: Fanjing
authors: F
authors: Meng
authors: Institute of Translational Medicine, Nanchang University, Nanchang, Jiangxi 330031, China.
authors: Shaoguo
authors: S
authors: Yang
authors: Institute of Translational Medicine, Nanchang University, Nanchang, Jiangxi 330031, China.
authors: Keyu
authors: K
authors: Deng
authors: Institute of Translational Medicine, Nanchang University, Nanchang, Jiangxi 330031, China.
authors: Tingtao
authors: 0000-0002-0506-8536
authors: T
authors: Chen
authors: Institute of Translational Medicine, Nanchang University, Nanchang, Jiangxi 330031, China.
authors: Hongbo
authors: 0000-0002-4257-207X
authors: H
authors: Xin
mesh_terms: D000504:Aloe / Q000737:chemistry*; D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology; D000893:Anti-Inflammatory Agents / Q000737:chemistry* / Q000494:pharmacology; D000975:Antioxidants / Q000737:chemistry*; D004926:Escherichia coli / Q000187:drug effects; D005285:Fermentation; D053583:Interleukin-1beta / Q000235:genetics / Q000378:metabolism; D015850:Interleukin-6 / Q000235:genetics / Q000378:metabolism; D048191:Lactiplantibacillus plantarum / Q000378:metabolism*; D008089:Listeria monocytogenes / Q000187:drug effects; D011425:Propionibacterium acnes / Q000187:drug effects; D012477:Salmonella enteritidis / Q000187:drug effects; D012486:Salmonella typhimurium / Q000187:drug effects; D012763:Shigella flexneri / Q000187:drug effects; D013211:Staphylococcus aureus / Q000187:drug effects; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics / Q000378:metabolism
chemical_list: D000900:Anti-Bacterial Agents; D000893:Anti-Inflammatory Agents; D000975:Antioxidants; D053583:Interleukin-1beta; D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha