title: Membranome: a database for proteome-wide analysis of single-pass membrane proteins.
abstract: The Membranome database was developed to assist analysis and computational modeling of single-pass (bitopic) transmembrane (TM) proteins and their complexes by providing structural information about these proteins on a genomic scale. The database currently collects data on >6000 bitopic proteins from Homo sapiens, Arabidopsis thaliana, Dictyostelium discoideum, Saccharomyces cerevisiae, Escherichia coli and Methanocaldococcus jannaschii It presents the following data: (i) hierarchical classification of bitopic proteins into 15 functional classes, 689 structural superfamilies and 1404 families; (ii) 446 complexes of bitopic proteins with known three-dimensional (3D) structures classified into 129 families; (iii) computationally generated three-dimensional models of TM α-helices positioned in membranes; (iv) amino acid sequences, domain architecture, functional annotation and available experimental structures of bitopic proteins; (v) TM topology and intracellular localization, (vi) physical interactions between proteins from the database along with links to other resources. The database is freely accessible at http://membranome.org There is a variety of options for browsing, sorting, searching and retrieval of the content, including downloadable coordinate files of TM domains with calculated membrane boundaries.
authors: Department of Medicinal Chemistry, College of Pharmacy, University of Michigan, Ann Arbor, MI 48109-1065, USA almz@umich.edu.
authors: Andrei L
authors: AL
authors: Lomize
authors: St. Anthony Hospital, Oklahoma City, OK 73102, USA.
authors: Mikhail A
authors: MA
authors: Lomize
authors: Department of Computational Science and Engineering, University of Michigan, Ann Arbor, MI 48109-1065, USA.
authors: Shean R
authors: SR
authors: Krolicki
authors: Department of Medicinal Chemistry, College of Pharmacy, University of Michigan, Ann Arbor, MI 48109-1065, USA.
authors: Irina D
authors: ID
authors: Pogozheva
mesh_terms: D019295:Computational Biology / Q000379:methods; D030562:Databases, Protein; D008565:Membrane Proteins; D008958:Models, Molecular; D011487:Protein Conformation; D020543:Proteome; D040901:Proteomics / Q000379:methods*; D012984:Software; D064878:Web Browser
chemical_list: D008565:Membrane Proteins; D020543:Proteome