title: Efficacy of Tumor-Targeting Salmonella A1-R on a Melanoma Patient-Derived Orthotopic Xenograft (PDOX) Nude-Mouse Model.
abstract: Tumor-targeting Salmonella enterica serovar Typhimurium A1-R (Salmonella A1-R) had strong efficacy on a melanoma patient-derived orthotopic xenograft (PDOX) nude-mouse model. GFP-expressing Salmonella A1-R highly and selectively colonized the PDOX melanoma and significantly suppressed tumor growth (p = 0.021). The combination of Salmonella A1-R and cisplatinum (CDDP), both at low-dose, also significantly suppressed the growth of the melanoma PDOX (P = 0.001). Salmonella A1-R has future clinical potential for combination chemotherapy with CDDP of melanoma, a highly-recalcitrant cancer.
authors: AntiCancer, Inc., Ostrow Street, San Diego, California, United States of America.|Department of Surgery, University of California San Diego, West Arbor Drive, San Diego, California, United States of America.
authors: Mako
authors: M
authors: Yamamoto
authors: AntiCancer, Inc., Ostrow Street, San Diego, California, United States of America.
authors: Ming
authors: M
authors: Zhao
authors: AntiCancer, Inc., Ostrow Street, San Diego, California, United States of America.|Department of Surgery, University of California San Diego, West Arbor Drive, San Diego, California, United States of America.
authors: Yukihiko
authors: Y
authors: Hiroshima
authors: AntiCancer, Inc., Ostrow Street, San Diego, California, United States of America.
authors: Yong
authors: Y
authors: Zhang
authors: Division of Surgical Oncology, University of California Los Angeles, Los Angeles, California, United States of America.
authors: Elizabeth
authors: E
authors: Shurell
authors: Division of Surgical Oncology, University of California Los Angeles, Los Angeles, California, United States of America.
authors: Fritz C
authors: FC
authors: Eilber
authors: Department of Surgery, University of California San Diego, West Arbor Drive, San Diego, California, United States of America.
authors: Michael
authors: M
authors: Bouvet
authors: Department of Molecular Oncology, Kyoto University Graduate School of Medicine, Yoshida-Konoe-cho, Sakyo-ku, Kyoto, Japan.
authors: Makoto
authors: M
authors: Noda
authors: AntiCancer, Inc., Ostrow Street, San Diego, California, United States of America.|Department of Surgery, University of California San Diego, West Arbor Drive, San Diego, California, United States of America.
authors: Robert M
authors: RM
authors: Hoffman
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D003131:Combined Modality Therapy; D004195:Disease Models, Animal; D006801:Humans; D008545:Melanoma / Q000382:microbiology / Q000628:therapy*; D051379:Mice; D008819:Mice, Nude; D012480:Salmonella Infections / Q000382:microbiology*; D012486:Salmonella typhimurium / Q000254:growth & development*; D023041:Xenograft Model Antitumor Assays
chemical_list: D000970:Antineoplastic Agents