title: Eosinophilic esophagitis.
abstract: Eosinophilic esophagitis (EoE) is a clinico-pathological entity characterised by symptoms of esophageal dysfunction and eosinophilia on esophageal mucosal biopsies in the absence of other causes of esophageal eosinophilia. It is a chronic inflammatory condition of esophagus often characterized by refractory reflux symptoms in children and dysphagia in adults. It occurs as a result of Th2 inflammatory response to environmental triggers (food antigens) in genetically predisposed individuals. The diagnostic criteria include symptoms of esophageal dysfunction, esophageal eosinophilia (> 15/hpf), and a PPI trial (persistent eosinophilia after 8 weeks of PPI). Mainstay of treatment at present is topical steroids and dietary therapy. Maintenance treatment should be considered to prevent long term complications.
authors: Saurabh
authors: S
authors: Kedia
authors: Bhaskar Jyoti
authors: BJ
authors: Baruah
authors: Govind
authors: G
authors: Makharia
authors: Vineet
authors: V
authors: Ahuja
mesh_terms: D003937:Diagnosis, Differential; D057765:Eosinophilic Esophagitis / Q000175:diagnosis* / Q000453:epidemiology / Q000628:therapy*; D006801:Humans