title: Genetics of Male Infertility.
abstract: While 7 % of the men are infertile, currently, a genetic etiology is identified in less than 25 % of those men, and 30 % of the infertile men lack a definitive diagnosis, falling in the "idiopathic infertility" category. Advances in genetics and epigenetics have led to several proposed mechanisms for male infertility. These advances may result in new diagnostic tools, treatment approaches, and better counseling with regard to treatment options and prognosis. In this review, we focus on clinical aspects of male infertility and the role of genetics in elucidating etiologies and the potential of treatments.
authors: Center for Male Reproductive Medicine and Microsurgery, Department of Urology and Institute of Reproductive Medicine, Weill Cornell Medical College, New York, NY, USA.
authors: Filipe Tenorio Lira
authors: FT
authors: Neto
authors: Center for Male Reproductive Medicine and Microsurgery, Department of Urology and Institute of Reproductive Medicine, Weill Cornell Medical College, New York, NY, USA.
authors: Phil Vu
authors: PV
authors: Bach
authors: Center for Male Reproductive Medicine and Microsurgery, Department of Urology and Institute of Reproductive Medicine, Weill Cornell Medical College, New York, NY, USA.
authors: Bobby Baback
authors: BB
authors: Najari
authors: Center for Male Reproductive Medicine and Microsurgery, Department of Urology and Institute of Reproductive Medicine, Weill Cornell Medical College, New York, NY, USA.
authors: Philip Shihua
authors: PS
authors: Li
authors: Center for Male Reproductive Medicine and Microsurgery, Department of Urology and Institute of Reproductive Medicine, Weill Cornell Medical College, New York, NY, USA. mgoldst@med.cornell.edu.
authors: Marc
authors: M
authors: Goldstein
mesh_terms: D002872:Chromosome Deletion; D041322:Chromosomes, Human, Y; D019005:Cystic Fibrosis Transmembrane Conductance Regulator / Q000235:genetics; D004249:DNA Damage; D019175:DNA Methylation; D012734:Disorders of Sex Development / Q000235:genetics; D014644:Genetic Variation; D006801:Humans; D007248:Infertility, Male / Q000235:genetics*; D008297:Male; D014176:Protein Biosynthesis
chemical_list: D019005:Cystic Fibrosis Transmembrane Conductance Regulator
keywords: Epigenetics; Genetics; Male infertility; Reproduction