title: New pregnane and phenolic glycosides from Solenostemma argel.
abstract: From the aerial parts, pericarps and roots of Solenostemma argel, three new pregnane glycosides (1-3) with two known ones and a new phenolic glycoside (4) have been isolated. Their structures were established by extensive 1D - and 2D NMR and mass spectroscopic analysis. The cytotoxicity of all compounds was evaluated against two human tumor cell lines (SW 480, MCF-7), but none of them was active in the concentration range 0.9-59.0μM. Compounds 2 and the known argeloside F at non toxic concentrations for the PBMCs (27.3μM and 27.6μM, respectively) significantly decreased the Il-1β production by LPS-stimulated PBMCs. All isolated compounds showed a significant antioxidant potential with ORAC values in the concentration range 3481-9617μmoleq. Trolox/100g.
authors: EA 4267, FDE, Laboratoire de Pharmacognosie, UFR des Sciences de Santé, Université de Bourgogne Franche-Comté, BP 87900, 21079 Cedex, France; Pharmacy Department, Faculty of Medicine, Annaba University, Algeria.
authors: Karima
authors: K
authors: Ounaissia
authors: EA 4267, FDE, Laboratoire de Pharmacognosie, UFR des Sciences de Santé, Université de Bourgogne Franche-Comté, BP 87900, 21079 Cedex, France.
authors: David
authors: D
authors: Pertuit
authors: EA 4267, FDE, Laboratoire de Pharmacognosie, UFR des Sciences de Santé, Université de Bourgogne Franche-Comté, BP 87900, 21079 Cedex, France.
authors: Anne-Claire
authors: AC
authors: Mitaine-Offer
authors: Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka 812-8582, Japan.
authors: Tomofumi
authors: T
authors: Miyamoto
authors: Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka 812-8582, Japan.
authors: Chiaki
authors: C
authors: Tanaka
authors: Cohiro, UFR des Sciences de Santé, 7, Bd. Jeanne d'Arc, BP 87900, 21079 Dijon Cedex, France.
authors: Stéphanie
authors: S
authors: Delemasure
authors: Cohiro, UFR des Sciences de Santé, 7, Bd. Jeanne d'Arc, BP 87900, 21079 Dijon Cedex, France.
authors: Patrick
authors: P
authors: Dutartre
authors: Pharmacy Department, Faculty of Medicine, Alger University, Algeria.
authors: Dalila
authors: D
authors: Smati
authors: EA 4267, FDE, Laboratoire de Pharmacognosie, UFR des Sciences de Santé, Université de Bourgogne Franche-Comté, BP 87900, 21079 Cedex, France. Electronic address: m-a.lacaille-dubois@u-bourgogne.fr.
authors: Marie-Aleth
authors: MA
authors: Lacaille-Dubois
mesh_terms: D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000302:isolation & purification; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification; D029062:Apocynaceae / Q000737:chemistry*; D045744:Cell Line, Tumor; D006027:Glycosides / Q000737:chemistry* / Q000302:isolation & purification; D006801:Humans; D007963:Leukocytes, Mononuclear / Q000187:drug effects; D015394:Molecular Structure; D010636:Phenols / Q000737:chemistry* / Q000302:isolation & purification; D010936:Plant Extracts / Q000737:chemistry; D018517:Plant Roots / Q000737:chemistry; D011278:Pregnanes / Q000737:chemistry* / Q000302:isolation & purification
chemical_list: D000893:Anti-Inflammatory Agents; D000972:Antineoplastic Agents, Phytogenic; D006027:Glycosides; D010636:Phenols; D010936:Plant Extracts; D011278:Pregnanes; C574437:pregnane glycoside
keywords: Anti-inflammatory; Antioxidant; Apocynaceae; Cytotoxicity; Phenolic glycosides; Pregnane glycosides; Solenostemma argel