title: Cytotoxic constituents of Alocasia macrorrhiza.
abstract: An indole alkaloid, 2-(5-hydroxy-1H-indol-3-yl)-2-oxo-acetic acid (1) isolated for the first time from nature, in addition to the nine known compounds 5-hydroxy-1H-indole-3-carboxylic acid methyl ester (2), alocasin B (3), hyrtiosin B (4), α-monopalmitin (5), 1-O-β-D-glucopyranosyl-(2S, 3R, 4E, 8Z)-2-[(2(R)-hydroctadecanoyl) amido]-4,8-octadecadiene-1,3-diol (6), 3-epi-betulinic acid (7), 3-epi-ursolic acid (8), β-sitosterol (9) and β-sitosterol 3-O-β-D-glucoside (10) were isolated from the rhizomes of Alocasia macrorrhiza (Araceae). Their structures were elucidated by 1D and 2D NMR spectroscopic data. Of these compounds, 6 exhibited the strongest cytotoxicity against the four tested human cancer cell lines (IC50 of about 10 µM against Hep-2 larynx cancer cells).
authors: Pharmacognosy Department, Faculty of Pharmacy, Mansoura University, Mansoura 35516, Egypt, Phone: +00201005437480, Fax: +02(050)2213101.
authors: Marwa
authors: M
authors: Elsbaey
authors: Pharmacognosy Department, Faculty of Pharmacy, Mansoura University, Mansoura 35516, Egypt.
authors: Kadria F M
authors: KFM
authors: Ahmed
authors: Pharmacognosy Department, Faculty of Pharmacy, Mansoura University, Mansoura 35516, Egypt.
authors: Mahmoud F
authors: MF
authors: Elsebai
authors: Pharmacognosy Department, Faculty of Pharmacy, Mansoura University, Mansoura 35516, Egypt.|Pharmacognosy Department, Faculty of Pharmacy, Salman Bin Abdulaziz University, Riyadh 11451, Saudi Arabia.
authors: Ahmed
authors: A
authors: Zaghloul
authors: Pharmacognosy Department, Faculty of Pharmacy, Mansoura University, Mansoura 35516, Egypt.
authors: Mohamed M A
authors: MMA
authors: Amer
authors: Pharmacognosy Department, Faculty of Pharmacy, Mansoura University, Mansoura 35516, Egypt.
authors: Mohamed-Farid I
authors: MI
authors: Lahloub
mesh_terms: D031055:Alocasia / Q000737:chemistry* / Q000633:toxicity; D000972:Antineoplastic Agents, Phytogenic / Q000032:analysis / Q000302:isolation & purification / Q000494:pharmacology; D045744:Cell Line, Tumor; D003603:Cytotoxins / Q000032:analysis* / Q000302:isolation & purification / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D026121:Indole Alkaloids / Q000032:analysis* / Q000302:isolation & purification / Q000494:pharmacology; D020128:Inhibitory Concentration 50; D013058:Mass Spectrometry; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D027343:Rhizome / Q000737:chemistry
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D003603:Cytotoxins; D026121:Indole Alkaloids