title: Sepsis leads to thyroid impairment and dysfunction in rat model.
abstract: Sepsis was a systemic response to a local infection. Apoptosis was observed in the experimental sepsis. In this study, cecal ligation and puncture (CLP)-induced sepsis was established in rats. We found that sepsis decreased thyroid hormone levels, including triiodothyronine (T3), thyroxine (T4), free T3 (fT3), and free T4 (fT4). Besides, we detected the increasing expression level of Caspase-3 and increasing ratio of TUNEL positive cells in the thyroid after sepsis. Furthermore, a series of pathological ultrastructural changes were observed in thyroid follicular epithelial cells by CLP-induced sepsis. This study established a sepsis animal model and provided the cellular and molecular basis for decoding the pathological mechanism in thyroid with the occurrence of sepsis.
authors: The First Department of Intensive Care Medicine, Fujian Provincial South Branch Hospital, China; The Second Department of Intensive Care Medicine, Fujian Provincial Hospital, China. Electronic address: xingshenglin@yahoo.com.
authors: Xingsheng
authors: X
authors: Lin
authors: The Second Department of Intensive Care Medicine, Fujian Provincial Hospital, China.
authors: Songjing
authors: S
authors: Shi
authors: The First Department of Intensive Care Medicine, Fujian Provincial South Branch Hospital, China.
authors: Songchang
authors: S
authors: Shi
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000235:genetics; D004195:Disease Models, Animal; D005786:Gene Expression Regulation; D006801:Humans; D051381:Rats; D018805:Sepsis / Q000150:complications* / Q000378:metabolism / Q000473:pathology; D013959:Thyroid Diseases / Q000209:etiology / Q000378:metabolism / Q000473:pathology*; D013961:Thyroid Gland / Q000378:metabolism / Q000473:pathology / Q000648:ultrastructure*; D013972:Thyrotropin / Q000096:biosynthesis; D013974:Thyroxine / Q000096:biosynthesis; D014284:Triiodothyronine / Q000096:biosynthesis
chemical_list: D014284:Triiodothyronine; D013972:Thyrotropin; D013974:Thyroxine
keywords: Caspase-3; Rat model; Sepsis; TUNEL assay; Thyroid hormone