title: Vaspin, resistin, retinol-binding protein-4, interleukin-1α and interleukin-6 in patients with nonalcoholic fatty liver disease.
abstract: Background and rational. Data on newer adipokines and interleukins in patients with nonalcoholic fatty liver disease (NAFLD) are inconclusive. The primary aim of this study was the evaluation of serum vaspin, resistin, retinol-binding protein (RBP)-4, interleukin (IL)-1α and IL-6 levels in NAFLD patients compared to matched controls, and their association with disease severity.
  
  
  METHODS
  Twenty-nine consecutively enrolled NAFLD patients with histologically confirmed nonalcoholic simple steatosis (SS; n = 15) or steatohepatitis (NASH; n = 14) and 25 matched controls without NAFLD were recruited. Serum vaspin, resistin, RBP-4, IL-1α and IL-6 and biochemical tests were measured.
  
  
  RESULTS
  Serum vaspin levels were lower and IL-6 levels higher in NASH patients than controls, but similar between controls and SS patients, or NASH and SS patients (vaspin, controls: 728.5 ± 39.3; SS: 634.6 ± 63.7; NASH: 531.5 ± 52.0 pg/mL; p for trend 0.028; IL-6, controls: 1.5 ± 0.2; SS: 2.5 ± 0.6; NASH: 3.0 ± 0.6 pg/mL; p for trend 0.032). However, after adjustment for body mass index or waist circumference, both vaspin and IL-6 did not remain significantly different between groups. Resistin, RBP-4 and IL-1α were not statistically different between groups. None of the selected adipokines or interleukins could independently differentiate NAFLD from SS, or patients with more severe from less severe histological lesions.
  
  
  CONCLUSIONS
  Lower circulating vaspin, but higher IL-6 levels were observed in NASH patients than controls, whereas resistin, RBP-4 and IL-1α levels were similar between groups. However, these differences did not remain robust after adjustment for body mass index or waist circumference.
authors: Department of Medicine, Second Medical Clinic, Aristotle University of Thessaloniki, Ippokration Hospital, Thessaloniki, Greece.
authors: Stergios A
authors: SA
authors: Polyzos
authors: Department of Medicine, Second Medical Clinic, Aristotle University of Thessaloniki, Ippokration Hospital, Thessaloniki, Greece.
authors: Jannis
authors: J
authors: Kountouras
authors: Biomedicine Laboratories, Athens, Greece.
authors: Vaia
authors: V
authors: Polymerou
authors: Department of Medicine, Second Medical Clinic, Aristotle University of Thessaloniki, Ippokration Hospital, Thessaloniki, Greece.
authors: Kassiani G
authors: KG
authors: Papadimitriou
authors: Department of Medicine, Second Medical Clinic, Aristotle University of Thessaloniki, Ippokration Hospital, Thessaloniki, Greece.
authors: Christos
authors: C
authors: Zavos
authors: Department of Medicine, Second Medical Clinic, Aristotle University of Thessaloniki, Ippokration Hospital, Thessaloniki, Greece.
authors: Panagiotis
authors: P
authors: Katsinelos
mesh_terms: D015415:Biomarkers / Q000097:blood; D001706:Biopsy; D015992:Body Mass Index; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D005260:Female; D006115:Greece; D006801:Humans; D053582:Interleukin-1alpha / Q000097:blood*; D015850:Interleukin-6 / Q000097:blood*; D008297:Male; D008875:Middle Aged; D065626:Non-alcoholic Fatty Liver Disease / Q000097:blood* / Q000175:diagnosis; D011237:Predictive Value of Tests; D011379:Prognosis; D052243:Resistin / Q000097:blood*; D054839:Retinol-Binding Proteins, Plasma / Q000032:analysis*; D015843:Serpins / Q000097:blood*; D012720:Severity of Illness Index; D055105:Waist Circumference
chemical_list: D015415:Biomarkers; C508584:IL1A protein, human; C508600:IL6 protein, human; D053582:Interleukin-1alpha; D015850:Interleukin-6; C101326:RBP4 protein, human; C499624:RETN protein, human; D052243:Resistin; D054839:Retinol-Binding Proteins, Plasma; C507339:SERPINA12 protein, human; D015843:Serpins