title: Bone morphogenetic protein 2 (BMP2) may contribute to partition of energy storage into visceral and subcutaneous fat depots.
abstract: Bone morphogenetic proteins (BMPs) are important regulators of adipogenesis and may play a role in obesity. In this study, the hypothesis that BMP2 is related to adipose tissue (AT) distribution in obesity was tested.
  
  
  
  BMP2 serum concentration (n = 439) and BMP2 and Schnurri-1 and -2 mRNA expression were measured in paired samples of visceral and subcutaneous AT from 547 individuals with a wide range of body mass index. In addition, a single nucleotide polymorphism rs979012 in the BMP2 gene was genotyped for subsequent association studies on quantitative traits related to obesity in 631 individuals.
  
  
  
  BMP2 and Schnurri-1 mRNA were significantly higher in visceral compared with subcutaneous AT. Compared with individuals who were healthy and lean, BMP2 expression in both depots was significantly higher in people with obesity. Significantly higher BMP2 serum concentrations were found in patients with type 2 diabetes with moderate but not morbid obesity. Schnurri-1 and -2 mRNA expression was not related to either BMP2 expression or circulating BMP2. Finally, rs979012 showed nominal association with body mass index and total cholesterol levels.
  
  
  
  Data suggest that with increasing demand to store excessive energy, AT BMP2 expression increases and may contribute to partitioning of energy storage into visceral and subcutaneous AT depots.
authors: Core Unit, Animal Models of Obesity, IFB Adiposity Diseases, University of Leipzig, Leipzig, Germany.|Departament de Medicina i Cirurgia, Grup de recerca GEMMAIR (AGAUR)-Medicina Aplicada, Universitat Rovira i Virgili (URV), Institut d'Investigació Sanitària Pere Virgili (IISPV), Tarragona, Spain.
authors: Esther
authors: E
authors: Guiu-Jurado
authors: Core Unit, Animal Models of Obesity, IFB Adiposity Diseases, University of Leipzig, Leipzig, Germany.
authors: Mark
authors: M
authors: Unthan
authors: Department of Medicine, University of Leipzig, Leipzig, Germany.
authors: Nina
authors: N
authors: Böhler
authors: Department of Medicine, University of Leipzig, Leipzig, Germany.
authors: Matthias
authors: M
authors: Kern
authors: Department of Pediatric Endocrinology, Center for Pediatric Research Leipzig (CPL), Hospital for Children and Adolescents, University of Leipzig, Leipzig, Germany.
authors: Kathrin
authors: K
authors: Landgraf
authors: Core Unit, Animal Models of Obesity, IFB Adiposity Diseases, University of Leipzig, Leipzig, Germany.
authors: Arne
authors: A
authors: Dietrich
authors: Core Unit, Animal Models of Obesity, IFB Adiposity Diseases, University of Leipzig, Leipzig, Germany.
authors: Dorit
authors: D
authors: Schleinitz
authors: AG Knaus, Institute of Chemistry and Biochemistry, Freie Universität Berlin, Berlin, Germany.
authors: Karen
authors: K
authors: Ruschke
authors: Core Unit, Animal Models of Obesity, IFB Adiposity Diseases, University of Leipzig, Leipzig, Germany.
authors: Nora
authors: N
authors: Klöting
authors: Department of Medicine, University of Leipzig, Leipzig, Germany.
authors: Mathias
authors: M
authors: Faßhauer
authors: Department of Medicine, University of Leipzig, Leipzig, Germany.
authors: Anke
authors: A
authors: Tönjes
authors: Core Unit, Animal Models of Obesity, IFB Adiposity Diseases, University of Leipzig, Leipzig, Germany.|Department of Medicine, University of Leipzig, Leipzig, Germany.
authors: Michael
authors: M
authors: Stumvoll
authors: Core Unit, Animal Models of Obesity, IFB Adiposity Diseases, University of Leipzig, Leipzig, Germany.|Department of Pediatric Endocrinology, Center for Pediatric Research Leipzig (CPL), Hospital for Children and Adolescents, University of Leipzig, Leipzig, Germany.
authors: Antje
authors: A
authors: Körner
authors: Core Unit, Animal Models of Obesity, IFB Adiposity Diseases, University of Leipzig, Leipzig, Germany.
authors: Peter
authors: P
authors: Kovacs
authors: Core Unit, Animal Models of Obesity, IFB Adiposity Diseases, University of Leipzig, Leipzig, Germany. bluma@medizin.uni-leipzig.de.|Department of Medicine, University of Leipzig, Leipzig, Germany. bluma@medizin.uni-leipzig.de.
authors: Matthias
authors: M
authors: Blüher
mesh_terms: D000328:Adult; D015992:Body Mass Index; D055396:Bone Morphogenetic Protein 2 / Q000235:genetics*; D019485:Bone Morphogenetic Proteins / Q000235:genetics*; D003924:Diabetes Mellitus, Type 2 / Q000378:metabolism; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000235:genetics*; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide; D012333:RNA, Messenger / Q000378:metabolism; D050151:Subcutaneous Fat / Q000378:metabolism*
chemical_list: C525718:BMP2 protein, human; D055396:Bone Morphogenetic Protein 2; D019485:Bone Morphogenetic Proteins; D012333:RNA, Messenger