title: Mitochondrial DNA Damage and Diseases.
abstract: Various endogenous and environmental factors can cause mitochondrial DNA (mtDNA) damage.  One of the reasons for enhanced mtDNA damage could be its proximity to the source of oxidants, and lack of histone-like protective proteins. Moreover, mitochondria contain inadequate DNA repair pathways, and, diminished DNA repair capacity may be one of the factors responsible for high mutation frequency of the mtDNA. mtDNA damage might cause impaired mitochondrial function, and, unrepaired mtDNA damage has been frequently linked with several diseases. Exploration of mitochondrial perspective of diseases might lead to a better understanding of several diseases, and will certainly open new avenues for detection, cure, and prevention of ailments.
authors: School of Biotechnology and Biosciences, Lovely Professional University, Phagwara, Punjab, India.
authors: Gyanesh
authors: G
authors: Singh
authors: School of Biotechnology and Biosciences, Lovely Professional University, Phagwara, Punjab, India.
authors: U C
authors: UC
authors: Pachouri
authors: School of Biotechnology and Biosciences, Lovely Professional University, Phagwara, Punjab, India.
authors: Devika Chanu
authors: DC
authors: Khaidem
authors: School of Biotechnology and Biosciences, Lovely Professional University, Phagwara, Punjab, India.
authors: Aman
authors: A
authors: Kundu
authors: School of Biotechnology and Biosciences, Lovely Professional University, Phagwara, Punjab, India.
authors: Chirag
authors: C
authors: Chopra
authors: Department of Medicine, Punjab Institute of Medical Sciences, Jalandhar, Punjab, India.
authors: Pushplata
authors: P
authors: Singh
keywords: Oxidative damage; mitochondrial DNA repair; mitochondrial mutations; mitochondrial pathology