title: Removal Dynamics of Immunoglobulin and Fibrinogen by Conventional Plasma Exchange, Selective Plasma Exchange, and a Combination of the Two.
abstract: While plasma exchange (PE) can eliminate plasma proteins, including all immunoglobulin (Ig) and coagulation factors, selective plasma exchange (SePE) can retain fibrinogen (Fbg). Here, we investigated the removal dynamics of Ig and Fbg in 53 patients with immunological disorders by PE, SePE, and a combination of the two. When the mean processed plasma volume (PPV) was 0.9 plasma volume (PV), the mean percent reductions of Ig and Fbg by PE were both approximately 62%-65%. When the mean PPV was 1.1 PV, the mean percent reductions by SePE were 53.1% for IgG, 30.1% for IgA, 3.6% for IgM, and 19.0% for Fbg, respectively. In the three plasmapheresis sessions performed on alternate days, we classified treatments into three categories: PE group (PE-PE-PE, N = 2), SePE group (SePE-SePE-SePE, N = 14), and PE/SePE group (PE-SePE-SePE, N = 4). The mean percent reductions of IgG, IgA, IgM, and Fbg were 82.0%, 80.4%, 87.3%, and 80.9%, respectively, for the PE group; 76.4%, 57.7%, 43.3%, and 35.9%, respectively, for the PE/SePE group; and 75.4%, 50.6%, 3.2%, and 29.3%, respectively, for the SePE group. Plasmapheresis modalities can be combined according to clinical conditions, for instance, to achieve both the unspecific removal of pathogens by PE and retention of coagulation factors, such as Fbg, by SePE.
authors: Medical Engineering Center, Medical Hospital of Tokyo Medical and Dental University.
authors: Satoko
authors: S
authors: Miyamoto
authors: Medical Engineering Center, Medical Hospital of Tokyo Medical and Dental University.
authors: Atsushi
authors: A
authors: Ohkubo
authors: Medical Engineering Center, Medical Hospital of Tokyo Medical and Dental University.
authors: Hiroshi
authors: H
authors: Seshima
authors: Medical Engineering Center, Medical Hospital of Tokyo Medical and Dental University.
authors: Takuma
authors: T
authors: Maeda
authors: Medical Engineering Center, Medical Hospital of Tokyo Medical and Dental University.
authors: Ayako
authors: A
authors: Itagaki
authors: Medical Engineering Center, Medical Hospital of Tokyo Medical and Dental University.
authors: Naoki
authors: N
authors: Kurashima
authors: Department of Nephrology, Tokyo Medical and Dental University.
authors: Soichiro
authors: S
authors: Iimori
authors: Department of Nephrology, Tokyo Medical and Dental University.
authors: Shotaro
authors: S
authors: Naito
authors: Department of Nephrology, Tokyo Medical and Dental University.
authors: Eisei
authors: E
authors: Sohara
authors: Department of Nephrology, Tokyo Medical and Dental University.
authors: Tatemitsu
authors: T
authors: Rai
authors: Department of Nephrology, Tokyo Medical and Dental University.
authors: Shinichi
authors: S
authors: Uchida
authors: Department of Nephrology, Tokyo Medical and Dental University.
authors: Tomokazu
authors: T
authors: Okado
mesh_terms: D005260:Female; D005340:Fibrinogen; D006801:Humans; D007154:Immune System Diseases / Q000628:therapy*; D007136:Immunoglobulins / Q000097:blood*; D008297:Male; D008875:Middle Aged; D010951:Plasma Exchange / Q000379:methods*
chemical_list: D007136:Immunoglobulins; D005340:Fibrinogen
keywords: Combination therapy; Fibrinogen; Immunoglobulin; Plasma exchange; Selective plasma exchange