title: SLCO1B1 gene polymorphisms do not influence plasma rifampicin concentrations in a South Indian population.
abstract: To determine the effect of SLCO1B1 gene polymorphisms (rs11045819, rs4149032 and rs4149033) on rifampicin (RMP) concentrations in adult tuberculosis (TB) patients from south India.
  
  
  
  We genotyped adult TB patients for three SLCO1B1 gene polymorphisms-rs11045819, rs4149032 and rs4149033-and compared 2-h post-dosing RMP concentrations of the different genotypes for each of the polymorphisms. Plasma RMP was determined using high-performance liquid chromatography. Genotyping was performed using direct sequencing.
  
  
  
  Among the 256 study patients, minor allele frequencies were respectively 0.01 (A), 0.46 (C) and 0.07 (A) for rs11045819, rs4149032 and rs4149033 polymorphisms; genotype distributions followed Hardy-Weinberg equilibrium. RMP concentrations did not significantly differ between the different genotypes of the three polymorphisms.
  
  
  
  This is the first study to show that rs11045819, rs4149032 and rs4149033 polymorphisms in the SLCO1B1 gene did not influence RMP concentrations in Indian patients.
authors: National Institute for Research in Tuberculosis, Chennai, India.
authors: K
authors: K
authors: Ramesh
authors: National Institute for Research in Tuberculosis, Chennai, India.
authors: A K
authors: AK
authors: Hemanth Kumar
authors: National Institute for Research in Tuberculosis, Chennai, India.
authors: T
authors: T
authors: Kannan
authors: National Institute for Research in Tuberculosis, Chennai, India.
authors: R
authors: R
authors: Vijayalakshmi
authors: National Institute for Research in Tuberculosis, Chennai, India.
authors: V
authors: V
authors: Sudha
authors: National Institute for Research in Tuberculosis, Chennai, India.
authors: S
authors: S
authors: Manohar Nesakumar
authors: National Institute for Research in Tuberculosis, Chennai, India.
authors: T
authors: T
authors: Bharathiraja
authors: Chennai Corporation, Chennai, India.
authors: J
authors: J
authors: Lavanya
authors: National Institute for Research in Tuberculosis, Chennai, India.
authors: S
authors: S
authors: Swaminathan
authors: National Institute for Research in Tuberculosis, Chennai, India.
authors: G
authors: G
authors: Ramachandran
mesh_terms: D000328:Adult; D000904:Antibiotics, Antitubercular / Q000097:blood* / Q000627:therapeutic use; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D060005:Genotyping Techniques; D006801:Humans; D007194:India / Q000453:epidemiology; D027381:Liver-Specific Organic Anion Transporter 1 / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D012293:Rifampin / Q000097:blood* / Q000627:therapeutic use; D014376:Tuberculosis / Q000097:blood / Q000188:drug therapy / Q000235:genetics; D044465:White People / Q000235:genetics*
chemical_list: D000904:Antibiotics, Antitubercular; D027381:Liver-Specific Organic Anion Transporter 1; C503999:SLCO1B1 protein, human; D012293:Rifampin