title: Expression of sirtuins 1, 6, tumor necrosis factor, and interferon-γ in psoriatic patients.
abstract: Sirtuins (SIRT) have been regarded as culprits in the pathogenesis of various diseases. Their exact role has not been explained. This study aimed to assess the expression of SIRT1, SIRT6, tumor necrosis factor (TNF)-α, and interferon (IFN)-γ in psoriatic patients. Thirty psoriatic patients and 22 controls were enrolled. Clinical examination and Psoriasis Area and Severity Index (PASI) were obtained. Two skin biopsies (lesional, peri-lesional) and one from controls were obtained. Tissue levels of SIRT1, SIRT6, TNF-α, and IFN-γ were measured using ELISA. SIRT1 was significantly lower in lesional skin with gradual increase in perilesional followed by control skin (P <0.001). SIRT6, TNF-α, and IFN-γ were significantly higher in lesional than perilesional and control skin (P <0.001). Significant positive correlations were found between SIRT1 and TNF-α, IFN-γ and between SIRT6 and TNF-α in peri-lesional skin. SIRT1 and SIRT6 are potentially involved in the pathogenesis of psoriasis. Modulating their action could offer a novel therapy for such disease.
authors: Dermatology Department, Faculty of Medicine, Cairo University, Egypt.
authors: H
authors: H
authors: Rasheed
authors: Dermatology Department, Faculty of Medicine, Cairo University, Egypt.
authors: Mhm
authors: M
authors: El-Komy
authors: Dermatology Department, Faculty of Medicine, Cairo University, Egypt.
authors: R A
authors: RA
authors: Hegazy
authors: Dermatology Department, Faculty of Medicine, Cairo University, Egypt heba.gawdat@yahoo.com.
authors: H I
authors: HI
authors: Gawdat
authors: Dermatology Department, Faculty of Medicine, Cairo University, Egypt.
authors: A M
authors: AM
authors: AlOrbani
authors: Biochemistry Department, Faculty of Medicine, Cairo University, Egypt.
authors: O G
authors: OG
authors: Shaker
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D007371:Interferon-gamma / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D011565:Psoriasis / Q000378:metabolism*; D056564:Sirtuin 1 / Q000378:metabolism*; D037761:Sirtuins / Q000378:metabolism*; D012867:Skin / Q000378:metabolism; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism*; D055815:Young Adult
chemical_list: D014409:Tumor Necrosis Factor-alpha; D007371:Interferon-gamma; C447939:SIRT1 protein, human; C516592:SIRT6 protein, human; D056564:Sirtuin 1; D037761:Sirtuins
keywords: IFN-γ; Pathogenesis; Psoriasis; Sirtuins 1 and 6; TNF-α