title: Different Contributions of Physical Activity on Arterial Stiffness between Diabetics and Non-Diabetics.
abstract: BACKGROUND
  We compared the contribution of physical activity to the change in arterial stiffness between patients with and without diabetes in ischemic heart disease.
  
  
  METHODS
  We studied 96 (diabetes) and 109 (without diabetes) patients with ischemic heart disease treated by percutaneous coronary intervention (PCI). Arterial stiffness was assessed by cardio-ankle vascular index (CAVI) at the first diagnosis of significant coronary ischemia and 6 months after PCI and optimal medical therapy. Physical activity was evaluated using the long form of the International Physical Activity Questionnaire (IPAQ).
  
  
  RESULTS
  CAVI values increased more for diabetic patients than for non-diabetic. The IPAQ scores did not differ between the two groups. During follow-up, CAVI values did not significantly change in either group. In diabetic patients, the CAVI score for 48 patients did not change (NC-group) and 48 patients improved (Improved-group). Physical activity scores were 937.9 ± 923.2 and 1524.6 ± 1166.2 in the NC- and Improved-groups, respectively. IPAQ scores and uric acid levels significantly affect CAVI improvement after adjusting for age, sex, baseline CAVI, total cholesterol, and estimated glomerular filtration rate.
  
  
  CONCLUSIONS
  Determining factors influencing CAVI improvement during follow-up were significantly different between patients with and without diabetes. IPAQ scores and uric acid levels were significantly correlated with CAVI changes.
authors: Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.|Department of General Internal Medicine, Oncologic Emergencies, National Cancer Center Hospital, Tokyo, Japan.
authors: Takeshi
authors: T
authors: Iwasa
authors: Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
authors: Eisuke
authors: E
authors: Amiya
authors: Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
authors: Jiro
authors: J
authors: Ando
authors: Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
authors: Masafumi
authors: M
authors: Watanabe
authors: Department of Medical Engineering, The University of Tokyo, Tokyo, Japan.
authors: Takahide
authors: T
authors: Murasawa
authors: Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
authors: Issei
authors: I
authors: Komuro
mesh_terms: D000367:Age Factors; D000368:Aged; D055109:Ankle Brachial Index; D001794:Blood Pressure; D002784:Cholesterol / Q000097:blood; D003924:Diabetes Mellitus, Type 2 / Q000150:complications*; D015444:Exercise; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000150:complications / Q000175:diagnosis* / Q000601:surgery; D016017:Odds Ratio; D062645:Percutaneous Coronary Intervention; D012737:Sex Factors; D014527:Uric Acid / Q000032:analysis; D059289:Vascular Stiffness / Q000502:physiology*
chemical_list: D014527:Uric Acid; D002784:Cholesterol