title: Molecular Mechanisms of Arterial Stiffening.
abstract: Stiffening of large arteries is a hallmark of vascular aging and one of the most important determinants of the age-related increase in blood pressure and cardiovascular disease events. Despite a substantial genetic component, the molecular mechanisms underlying phenotypic variability in arterial stiffness remain unknown. Previous genetic studies have identified several genetic variants that are associated with measures of arterial stiffness. Here, we review the relevant advances in the identification of pathways underlying arterial stiffness from genomic studies.
authors: King's College London British Heart Foundation Centre, Department of Clinical Pharmacology, St. Thomas' Hospital, London, UK.
authors: Marina
authors: M
authors: Cecelja
authors: King's College London British Heart Foundation Centre, Department of Clinical Pharmacology, St. Thomas' Hospital, London, UK.
authors: Phil
authors: P
authors: Chowienczyk
keywords: Arterial calcification; Arterial stiffening; Cardiovascular disease; Genomic studies; Vascular aging