title: Noninvasive Focused Ultrasound Stimulation Can Modulate Phase-Amplitude Coupling between Neuronal Oscillations in the Rat Hippocampus.
abstract: Noninvasive focused ultrasound stimulation (FUS) can be used to modulate neural activity with high spatial resolution. Phase-amplitude coupling (PAC) between neuronal oscillations is tightly associated with cognitive processes, including learning, attention, and memory. In this study, we investigated the effect of FUS on PAC between neuronal oscillations and established the relationship between the PAC index and ultrasonic intensity. The rat hippocampus was stimulated using focused ultrasound at different spatial-average pulse-average ultrasonic intensities (3.9, 9.6, and 19.2 W/cm(2)). The local field potentials (LFPs) in the rat hippocampus were recorded before and after FUS. Then, we analyzed PAC between neuronal oscillations using a PAC calculation algorithm. Our results showed that FUS significantly modulated PAC between the theta (4-8 Hz) and gamma (30-80 Hz) bands and between the alpha (9-13 Hz) and ripple (81-200 Hz) bands in the rat hippocampus, and PAC increased with incremental increases in ultrasonic intensity.
authors: Institute of Electrical Engineering, Yanshan University Qinhuangdao, China.
authors: Yi
authors: Y
authors: Yuan
authors: School of Electrical and Control Engineering, North China University of Technology Beijing, China.
authors: Jiaqing
authors: J
authors: Yan
authors: Institute of Electrical Engineering, Yanshan University Qinhuangdao, China.
authors: Zhitao
authors: Z
authors: Ma
authors: State Key Laboratory of Cognitive Neuroscience and Learning and IDG/McGovern Institute for Brain Research, Beijing Normal UniversityBeijing, China; Center for Collaboration and Innovation in Brain and Learning Sciences, Beijing Normal UniversityBeijing, China.
authors: Xiaoli
authors: X
authors: Li
keywords: focused ultrasound stimulation; hippocampus; neuronal oscillation; phase-amplitude coupling; ultrasonic intensity