title: Radiological and Pathological Correlation in Anti-MDA5 Antibody-positive Interstitial Lung Disease: Rapidly Progressive Perilobular Opacities and Diffuse Alveolar Damage.
abstract: We herein present the first case of rapidly progressive interstitial lung disease (RP-ILD) with anti-melanoma differentiation-associated protein 5 (MDA5) antibody evaluated by surgical lung biopsy (SLB). High-resolution CT scan revealed perilobular opacities, which rapidly became thicker and formed consolidation, resulting in remarkable loss of lung volume. Specimens taken from SLB revealed membranous organization with alveolar occlusion, dilation of alveolar ducts, and sacs with collapsed alveoli, which are typical features of diffuse alveolar damage (DAD). Rapidly progressive perilobular opacities may be characteristic of RP-ILD with anti-MDA5 antibody and DAD.
authors: Department of Respiratory Medicine, Kanagawa Cardiovascular and Respiratory Center, Japan.
authors: Haruka
authors: H
authors: Chino
authors: Akimasa
authors: A
authors: Sekine
authors: Tomohisa
authors: T
authors: Baba
authors: Tae
authors: T
authors: Iwasawa
authors: Koji
authors: K
authors: Okudela
authors: Tamiko
authors: T
authors: Takemura
authors: Harumi
authors: H
authors: Itoh
authors: Shinji
authors: S
authors: Sato
authors: Yasuo
authors: Y
authors: Suzuki
authors: Takashi
authors: T
authors: Ogura
mesh_terms: D001323:Autoantibodies / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D003497:Cyclic N-Oxides / Q000097:blood*; D006801:Humans; D017563:Lung Diseases, Interstitial / Q000097:blood* / Q000000981:diagnostic imaging*; D008297:Male; D008875:Middle Aged; D011650:Pulmonary Alveoli; D014057:Tomography, X-Ray Computed
chemical_list: D001323:Autoantibodies; D015415:Biomarkers; D003497:Cyclic N-Oxides; C024516:N-(1-oxyl-2,2,5,5-tetramethyl-3-pyrrolidinyl)maleimide