title: Protective effects of heat-killed Lactococcus lactis subsp. lactis BF3, isolated from the intestine of chum salmon, in a murine model of DSS-induced inflammatory bowel disease.
abstract: Oxidative stress is considered an etiological factor responsible for several symptoms of inflammatory bowel disease (IBD). In vitro anti-inflammatory activities of heat-killed Lactococcus lactis subsp. lactis BF3 have been reported. In this study, the anti-inflammatory effect of these cells was examined using a dextran sodium sulphate (DSS)-induced murine IBD model. Administration of heat-killed L. lactis BF3 via drinking water suppressed the IBD symptoms, such as shortening of colon length, damage to the colon mucosa as observed under the microscope, and spleen enlargement. This result suggests that heat-killed L. lactis BF3 has the potential to treat IBD.
authors: Department of Food Science and Technology, Tokyo University of Marine Science and Technology, 4-5-7 Konan, Minato-ku, Tokyo 108-8477, Japan.
authors: Toru
authors: T
authors: Nakata
authors: Department of Food Science and Technology, Tokyo University of Marine Science and Technology, 4-5-7 Konan, Minato-ku, Tokyo 108-8477, Japan.
authors: Shino
authors: S
authors: Hirano
authors: Department of Food Science and Technology, Tokyo University of Marine Science and Technology, 4-5-7 Konan, Minato-ku, Tokyo 108-8477, Japan.
authors: Yasushi
authors: Y
authors: Yokota
authors: Department of Food Science and Technology, Tokyo University of Marine Science and Technology, 4-5-7 Konan, Minato-ku, Tokyo 108-8477, Japan.
authors: Hajime
authors: H
authors: Takahashi
authors: Department of Food Science and Technology, Tokyo University of Marine Science and Technology, 4-5-7 Konan, Minato-ku, Tokyo 108-8477, Japan.
authors: Bon
authors: B
authors: Kimura
authors: Department of Food Science and Technology, Tokyo University of Marine Science and Technology, 4-5-7 Konan, Minato-ku, Tokyo 108-8477, Japan.
authors: Takashi
authors: T
authors: Kuda
authors: Nippon Barrier Free Co., Ltd.,1-41 Kandajimbo-cho, Chiyoda-ku, Tokyo 101-0051, Japan.
authors: Tadashi
authors: T
authors: Eto
authors: Nippon Barrier Free Co., Ltd.,1-41 Kandajimbo-cho, Chiyoda-ku, Tokyo 101-0051, Japan.
authors: Michiko
authors: M
authors: Kato
keywords: Lactococcus lactis; inflammatory bowel disease; mice