title: Systemic lupus erythematosus pregnancies: ten-year data from a single centre in Malaysia.
abstract: We performed a retrospective study of all systemic lupus erythematosus (SLE) pregnancies during a 10-year period (2006-2015) to describe the clinical features, maternal and foetal outcomes in our centre. There were 115 pregnancies in 86 women with SLE. Our patients had a mean age of 29.1 years (SD 5.80) and a mean disease duration of 44.63 months (SD 41.17). Fifteen patients had antiphospholipid syndrome (APS). Our patients had complicated pregnancies: 26.1% had SLE flares, 13.9% had pre-eclampsia and 45.1% needed caesarean sections. There were 23.3% foetal losses and 25% preterm deliveries in our patients. There was a higher rate of unplanned pregnancies and lupus flare among pregnancies with active SLE at conception. Pregnancies in lupus nephritis have higher incidence of lupus flares during pregnancy but similar maternal and foetal outcomes compared to those without nephritis. The prognostic indicators for adverse foetal outcome in our patients were flare of SLE (HR 4.08 [CI 95% 1.65-10.13, p < 0.01]) and APS (HR 3.07 [CI 95% 1.12-8.42, p < 0.05]) and the prognostic indicator for adverse maternal outcome was hypertension (HR 3.58 [CI 95% 1.30-9.90, p < 0.05]). Lupus pregnancies in our centre remained as high-risk pregnancies with significant maternal and foetal complications.
authors: Unit of Rheumatology, Department of Medicine, Sarawak General Hospital, Sarawak, Malaysia.
authors: C L
authors: CL
authors: Teh
authors: Unit of Rheumatology, Department of Medicine, Sarawak General Hospital, Sarawak, Malaysia.
authors: S A
authors: SA
authors: Wan
authors: Unit of Rheumatology, Department of Medicine, Sarawak General Hospital, Sarawak, Malaysia.
authors: Y K
authors: YK
authors: Cheong
authors: Unit of Rheumatology, Department of Medicine, Sarawak General Hospital, Sarawak, Malaysia.
authors: G R
authors: GR
authors: Ling
mesh_terms: D000328:Adult; D003430:Cross-Sectional Studies; D003906:Developing Countries; D005260:Female; D006801:Humans; D015994:Incidence; D008180:Lupus Erythematosus, Systemic / Q000175:diagnosis / Q000453:epidemiology / Q000276:immunology / Q000628:therapy; D008296:Malaysia / Q000453:epidemiology; D011247:Pregnancy; D011248:Pregnancy Complications / Q000175:diagnosis / Q000453:epidemiology / Q000276:immunology / Q000628:therapy; D011256:Pregnancy Outcome; D012189:Retrospective Studies; D018570:Risk Assessment; D012307:Risk Factors; D013997:Time Factors; D055815:Young Adult
keywords: Pregnancies; outcome; systemic lupus erythematosus