title: Effects of Cobalt Nitrate on Histopathological and Morphometric Changes in Rat Femoral Artery Vasospasm Model.
abstract: OBJECTIVE
  To determine the effects of cobalt nitrate on the arterial wall in a rat femoral artery vasospasm model.
  
  
  METHODS
  Experimental study.
  
  
  METHODS
  Faculty of Medicine, Istanbul University, between November 2009 and September 2010.
  
  
  METHODS
  Twenty-four rats were separated into three groups named group 1 (n=8, sham-control); group 2 (n=8, vasospasm), and group 3 (n=8, vasospasm + cobalt nitrate treated). Group 3 rats were subjected to intraperitoneal administration of 0.1 mg/kg/day cobalt nitrate for 7 days, followed by histological and morphometric analyses. ANOVAand post hoc analyses were carried out.
  
  
  RESULTS
  The mean vascular wall thickness of the group 1, 2 and 3 rats was found to be 133 ±13, 210 ±15 and 160 ±11 micron, respectively. The mean vascular lumen diameter of the group 1, 2 and 3 rats was 698 ±20, 240 ±15 and 540 ±22 micron, respectively. Arteries in the group 3 had thin smooth endothelium, thin mildly folded internal elastic lamina, and concentric smooth muscle cells. The mean vascular lumen diameter of the group 3 rats showed a significant decrease compared to the group 2 rats.
  
  
  CONCLUSIONS
  Cobalt nitrate may potentially serve as an agent in preventing cerebral vasospasm after a hemorrhagic episode.
authors: Department of Neurosurgery, Gaziosmanpasa Taksim Training and Research Hospital, Istanbul, Turkey.
authors: Saygin
authors: S
authors: Ucar
authors: Department of Neurosurgery, Abat Izzet Baysal University, Medical School, Bolu, Turkey.
authors: Yasar
authors: Y
authors: Dagistan
authors: Department of Neurosurgery, Derince Training and Research Hospital, Kocaeli, Turkey.
authors: Ali
authors: A
authors: Guler
mesh_terms: D000818:Animals; D003035:Cobalt / Q000494:pharmacology*; D004195:Disease Models, Animal; D005263:Femoral Artery / Q000187:drug effects* / Q000473:pathology / Q000503:physiopathology; D008297:Male; D051381:Rats; D020301:Vasospasm, Intracranial / Q000188:drug therapy* / Q000473:pathology
chemical_list: D003035:Cobalt; C025913:cobaltous nitrate