title: Closing the gap: astrocytes and brain metastasis.
abstract: Astrocytes are emerging as essential regulators of brain metastasis progression. In a current issue of Nature, Chen et al. identify a novel mechanism of astrocyte-carcinoma interaction and exploit vulnerabilities therein to slow brain metastatic growth in pre-clinical models.
authors: Edwin L. Steele Laboratory, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
authors: Gino B
authors: GB
authors: Ferraro
authors: Edwin L. Steele Laboratory, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
authors: David P
authors: DP
authors: Kodack
authors: Edwin L. Steele Laboratory, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
authors: Vasileios
authors: V
authors: Askoxylakis
authors: Edwin L. Steele Laboratory, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
authors: Rakesh K
authors: RK
authors: Jain
mesh_terms: D001253:Astrocytes; D001921:Brain; D001932:Brain Neoplasms; D017629:Gap Junctions; D006801:Humans; D009712:Nucleotides, Cyclic
chemical_list: D009712:Nucleotides, Cyclic; C584311:cyclic guanosine monophosphate-adenosine monophosphate