title: Prognostic Factors of Overall Survival in Upper Urinary Tract Carcinoma: A Systematic Review and Meta-analysis.
abstract: Several prognostic factors that influence overall survival after radical nephroureterectomy for upper urinary tract urothelial carcinoma have been described. We have performed a systematic review of the literature and meta-analysis. The clinicopathological factors associated with an increased risk of death were age, multifocality, lymphovascular invasion, pT3-4 stage, pT2 vs <pT2 stage, node-positive disease, tumor grade, tumor size, and positive surgical margins. This meta-analysis of published data identified 9 significant predictors of mortality that should be systematically assessed to propose a risk-based strategy for the choice of adjuvant therapy and surveillance after radical nephroureterectomy.
authors: Oncology Unit, Oncology Department, ASST Bergamo Ovest, Treviglio, Italy. Electronic address: faupe@libero.it.
authors: Fausto
authors: F
authors: Petrelli
authors: Urology Unit, Surgical Department, ASST Bergamo Ovest, Treviglio, Italy.
authors: Mohamed Ismail
authors: MI
authors: Yasser Hussein
authors: Urology Unit, Surgical Department, ASST Bergamo Ovest, Treviglio, Italy.
authors: Ivano
authors: I
authors: Vavassori
authors: Oncology Unit, Oncology Department, ASST Bergamo Ovest, Treviglio, Italy.
authors: Sandro
authors: S
authors: Barni
mesh_terms: D002277:Carcinoma / Q000175:diagnosis* / Q000401:mortality* / Q000628:therapy; D006801:Humans; D011379:Prognosis; D015996:Survival Rate; D014571:Urologic Neoplasms / Q000175:diagnosis* / Q000401:mortality* / Q000628:therapy; D019459:Urothelium