title: The Associations of HLA-A*02:01 and DRB1*11:01 with Hepatitis C Virus Spontaneous Clearance Are Independent of IL28B in the Chinese Population.
abstract: Spontaneous clearance of hepatitis C virus (HCV) occurs in 10-40% of the infections. Specific human leukocyte antigen (HLA) alleles have been identified in associating with HCV clearance. However, data on the association of HLA with the spontaneous clearance of HCV are scarce in the Chinese population. In the current study we studied the HLA class I and class II genes in 231 Chinese voluntary blood donors who had cleared HCV infection spontaneously compared to 429 subjects with chronic HCV infections. We also studied their IL28B SNP (rs8099917) genotype, since a number of investigators have found a strong association of IL28B with spontaneous or treatment induced HCV clearance. We found that HLA-A*02:01 and DQB1*05:02 distributed differently between the two groups after Bonferroni correction (odds ratio [OR] = 1.839, Pc = 0.024 and OR = 0.547, Pc = 0.016, respectively). Multivariate logistic regression analysis suggested that A*02:01 and DRB1*11:01 (OR = 1.798, P = 0.008 and OR = 1.921, P = 0.005, respectively) were associated with HCV spontaneous clearance, independent of age, gender and IL28B polymorphism. We concluded that in the Chinese population, HLA-A*02:01 and DRB1*11:01 might be associated with the host capacity to clear HCV independent of IL28B, which suggesting that the innate and adaptive immune responses both play an important role in the control of HCV.
authors: Guangzhou Blood Center, Guangzhou, Guangdong, China.|The Key Medical Disciplines and Specialties Program of Guangzhou, Guangdong, China.
authors: Jieting
authors: J
authors: Huang
authors: Guangzhou Blood Center, Guangzhou, Guangdong, China.|The Key Medical Disciplines and Specialties Program of Guangzhou, Guangdong, China.
authors: Ke
authors: K
authors: Huang
authors: Guangzhou Blood Center, Guangzhou, Guangdong, China.|The Key Medical Disciplines and Specialties Program of Guangzhou, Guangdong, China.
authors: Ru
authors: R
authors: Xu
authors: Guangzhou Blood Center, Guangzhou, Guangdong, China.|The Key Medical Disciplines and Specialties Program of Guangzhou, Guangdong, China.
authors: Min
authors: M
authors: Wang
authors: Guangzhou Blood Center, Guangzhou, Guangdong, China.|The Key Medical Disciplines and Specialties Program of Guangzhou, Guangdong, China.
authors: Qiao
authors: Q
authors: Liao
authors: Guangzhou Blood Center, Guangzhou, Guangdong, China.|The Key Medical Disciplines and Specialties Program of Guangzhou, Guangdong, China.
authors: Huaping
authors: H
authors: Xiong
authors: Department of Transfusion Medicine, School of Biotechnology, Southern Medical University, Guangzhou, Guangdong, China.
authors: Chengyao
authors: C
authors: Li
authors: Department of Transfusion Medicine, School of Biotechnology, Southern Medical University, Guangzhou, Guangdong, China.
authors: Xi
authors: X
authors: Tang
authors: Guangzhou Blood Center, Guangzhou, Guangdong, China.|The Key Medical Disciplines and Specialties Program of Guangzhou, Guangdong, China.
authors: Zhengang
authors: Z
authors: Shan
authors: Department of Epidemiology and Biostatistics, Faculty of Infectious Diseases, University of Georgia, Athens, GA, USA.
authors: Ming
authors: M
authors: Zhang
authors: Guangzhou Blood Center, Guangzhou, Guangdong, China.|The Key Medical Disciplines and Specialties Program of Guangzhou, Guangdong, China.
authors: Xia
authors: X
authors: Rong
authors: Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA.
authors: Kenrad
authors: K
authors: Nelson
authors: Guangzhou Blood Center, Guangzhou, Guangdong, China.|The Key Medical Disciplines and Specialties Program of Guangzhou, Guangdong, China.
authors: Yongshui
authors: Y
authors: Fu
mesh_terms: D000293:Adolescent; D000328:Adult; D044466:Asian People; D005260:Female; D056726:Genetic Association Studies; D015234:HLA-A Antigens / Q000235:genetics*; D016174:Hepacivirus / Q000276:immunology*; D006526:Hepatitis C / Q000235:genetics*; D006801:Humans; D007372:Interferons; D007378:Interleukins / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D009419:Nerve Tissue Proteins / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D016601:RNA-Binding Proteins / Q000235:genetics*; D055815:Young Adult; D000095022:Interferon Lambda
chemical_list: D015234:HLA-A Antigens; D007372:Interferons; D007378:Interleukins; D009419:Nerve Tissue Proteins; D016601:RNA-Binding Proteins; C000624353:interferon-lambda, human; D000095022:Interferon Lambda; C467044:RBM45 protein, human