title: Long-term effectiveness and safety of once-daily, single-entity, extended-release hydrocodone in patients of ≥75 years of age with moderate to severe nonmalignant and nonneuropathic pain.
abstract: In elderly (≥75 years) individuals, age-associated physiologic changes and a higher prevalence of comorbidities, polypharmacy, and increased susceptibility to medication-induced side effects complicate pain management. Hysingla®ER (HYD) is a once-daily, single-entity, extended-release hydrocodone formulation approved for the treatment of chronic pain that is insufficiently controlled by alternative treatments. In this post-hoc analysis of a previously reported study, the effectiveness and safety of HYD for the treatment of moderate-to-severe chronic pain among the elderly (≥75 years) for a 52-week duration was investigated. HYD dose administered during the maintenance period-remained relatively stable and provided clinically meaningful decreases in mean "pain over the last 24 h" and pain interference scores. Patients achieved pain control without additional non-study opioid use at the end of the study. Adverse events were typical of opioids. In summary, HYD provided clinically meaningful reduction of pain scores in elderly patients that were maintained over a 52-week period.
authors: Columbia University Medical Center, New York, NY, USA.
authors: Kathleen
authors: K
authors: Broglio
authors: Naples Anesthesia and Pain Associates, Naples, FL, USA.
authors: Joseph
authors: J
authors: Pergolizzi
authors: Purdue Pharma L.P., Stamford, CT, USA.
authors: Maribeth
authors: M
authors: Kowalski
authors: Purdue Pharma L.P., Stamford, CT, USA.
authors: Shau Yu
authors: SY
authors: Lynch
authors: Purdue Pharma L.P., Stamford, CT, USA. Electronic address: Ellie.He@pharma.com.
authors: Ellie
authors: E
authors: He
authors: Purdue Pharma L.P., Stamford, CT, USA.
authors: Warren
authors: W
authors: Wen
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000701:Analgesics, Opioid / Q000627:therapeutic use*; D059350:Chronic Pain / Q000188:drug therapy*; D003692:Delayed-Action Preparations / Q000627:therapeutic use; D064420:Drug-Related Side Effects and Adverse Reactions; D005260:Female; D006801:Humans; D006853:Hydrocodone / Q000627:therapeutic use*; D008297:Male; D059408:Pain Management / Q000379:methods*; D063487:Prescription Drug Misuse / Q000517:prevention & control
chemical_list: D000701:Analgesics, Opioid; D003692:Delayed-Action Preparations; D006853:Hydrocodone
keywords: Analgesia; Chronic pain; Elderly; Extended-release; Hydrocodone; Opioids