title: Lack of association between cytotoxic T-lymphocyte antigen-4 gene polymorphisms and lymphoid malignancy risk: evidence from a meta-analysis.
abstract: Cytotoxic T-lymphocyte antigen-4 (CTLA-4) polymorphisms have been associated with susceptibility to lymphoid malignancies. However, results from the published single studies are inconsistent. Therefore, the present meta-analysis was conducted to get a more accurate estimation of the relationship between CTLA-4 gene polymorphisms and the lymphoid malignancy risk. We identified nine independent studies accounting for 3090 subjects up to January 30, 2016. Summary odds ratios (OR) and 95 % confidence intervals (CI) were used to evaluate the risk of lymphoid malignancies. Overall, no significant association was found between +49A/G (rs231775), -318C/T (rs5742909), and +6230A/G (rs3087243) CTLA-4 gene polymorphisms and lymphoid malignancies. Furthermore, ethnicity (Asian and Caucasian) and histopathology subgroup analyses (non-Hodgkin's lymphoma) also failed to detect an association between the studied polymorphisms and lymphoid malignancy risk. Our study shows that common CTLA-4 gene polymorphisms may not contribute to lymphoid malignancy susceptibility based on the current evidence.
authors: Department of Anesthesiology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710004, Shaanxi, People's Republic of China.|Department of Hematology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710004, Shaanxi, People's Republic of China.
authors: Zhiming
authors: Z
authors: Dai
authors: Department of Emergency, The Affiliated Hospital of Yan'an University, Yan'an, 716000, Shaanxi, People's Republic of China.
authors: Chuanjie
authors: C
authors: Feng
authors: Department of Hematology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710004, Shaanxi, People's Republic of China. zhangwanggang2003@yahoo.com.
authors: Wanggang
authors: W
authors: Zhang
authors: Department of Hematology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710004, Shaanxi, People's Republic of China.
authors: Jie
authors: J
authors: Liu
authors: Department of Hematology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710004, Shaanxi, People's Republic of China.
authors: Xingmei
authors: X
authors: Cao
authors: Department of Hematology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710004, Shaanxi, People's Republic of China.
authors: Hui
authors: H
authors: Zhang
authors: Department of Hematology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710004, Shaanxi, People's Republic of China.|Department of Hematology and Immunology, The Affiliated Hospital of Yan'an University, Yan'an, 716000, Shaanxi, People's Republic of China.
authors: Yuhong
authors: Y
authors: Liu
authors: Department of Oncology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710004, Shaanxi, People's Republic of China.
authors: Meng
authors: M
authors: Wang
authors: Department of Oncology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710004, Shaanxi, People's Republic of China.
authors: Xinghan
authors: X
authors: Liu
authors: Department of Oncology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710004, Shaanxi, People's Republic of China. dzj0911@126.com.
authors: Zhijun
authors: Z
authors: Dai
mesh_terms: D060908:CTLA-4 Antigen / Q000235:genetics*; D016022:Case-Control Studies; D016001:Confidence Intervals; D005006:Ethnicity / Q000706:statistics & numerical data; D020022:Genetic Predisposition to Disease; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000453:epidemiology / Q000235:genetics*; D008223:Lymphoma / Q000453:epidemiology / Q000235:genetics*; D009101:Multiple Myeloma / Q000453:epidemiology / Q000235:genetics*; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D012306:Risk
chemical_list: D060908:CTLA-4 Antigen; C556706:CTLA4 protein, human
keywords: Cytotoxic T-lymphocyte antigen-4; Lymphoid malignancies; Meta-analysis; Polymorphisms