title: Leading indicators of mosquito-borne disease elimination.
abstract: Mosquito-borne diseases contribute significantly to the global disease burden. High-profile elimination campaigns are currently underway for many parasites, e.g.,Plasmodiumspp., the causal agent of malaria. Sustaining momentum near the end of elimination programs is often difficult to achieve and consequently quantitative tools that enable monitoring the effectiveness of elimination activities after the initial reduction of cases has occurred are needed. Documenting progress in vector-borne disease elimination is a potentially important application for the theory of critical transitions. Non-parametric approaches that are independent of model-fitting would advance infectious disease forecasting significantly. In this paper, we consider compartmental Ross-McDonald models that are slowly forced through a critical transition through gradually deployed control measures. We derive expressions for the behavior of candidate indicators, including the autocorrelation coefficient, variance, and coefficient of variation in the number of human cases during the approach to elimination. We conducted a simulation study to test the performance of each summary statistic as an early warning system of mosquito-borne disease elimination. Variance and coefficient of variation were highly predictive of elimination but autocorrelation performed poorly as an indicator in some control contexts. Our results suggest that tipping points (bifurcations) in mosquito-borne infectious disease systems may be foreshadowed by characteristic temporal patterns of disease prevalence.
authors: Odum School of Ecology, University of Georgia, Athens, GA 30602-2202 USA ; National Institute for Mathematical and Biological Synthesis (NIMBioS), 1122 Volunteer Boulevard, University of Tennessee, Knoxville, TN 37996-3410 USA.
authors: Suzanne M
authors: SM
authors: O'Regan
authors: North Hall High School, Gainesville, GA 30506 USA.
authors: Jonathan W
authors: JW
authors: Lillie
authors: Odum School of Ecology, University of Georgia, Athens, GA 30602-2202 USA.
authors: John M
authors: JM
authors: Drake
keywords: Critical slowing down; Critical transition; Disease elimination; Malaria; Transcritical bifurcation; Vector-borne disease; Vector-borne disease model