title: Lipoprotein lipase in chronic lymphocytic leukemia: function and prognostic implications.
abstract: Chronic lymphocytic leukemia (CLL) is a clinically heterogeneous disease characterized by the accumulation of a clonal population of B cells in peripheral blood, bone marrow, and lymphoid organs. More than 10 years ago, lipoprotein lipase (LPL) mRNA was identified as being strongly expressed in patients experiencing a more aggressive phenotype, while CLL patients with an indolent disease course lack expression of this marker. Since then, several reports confirmed the capability of LPL to predict CLL disease evolution at the moment of diagnosis. In contrast, data on the functional implications of LPL in CLL are scarce. LPL exerts a central role in overall lipid metabolism and transport, but plays additional, non-catalytic roles as well. Which of those is more important in the pathogenesis of CLL remains largely unclear. Here, we review the current knowledge on the prognostic and biological relevance of LPL in CLL.
authors: Department of Clinical Chemistry, Microbiology and Immunology, Ghent University Hospital, Ghent University, Ghent, Belgium.
authors: Ans
authors: A
authors: Rombout
authors: Department of Clinical Chemistry, Microbiology and Immunology, Ghent University Hospital, Ghent University, Ghent, Belgium.
authors: Bruno
authors: B
authors: Verhasselt
authors: Department of Clinical Chemistry, Microbiology and Immunology, Ghent University Hospital, Ghent University, Ghent, Belgium. Jan.Philippe@UGent.be.
authors: Jan
authors: J
authors: Philippé
mesh_terms: D002450:Cell Communication; D004789:Enzyme Activation; D015870:Gene Expression; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000235:genetics / Q000378:metabolism* / Q000401:mortality*; D008071:Lipoprotein Lipase / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D011379:Prognosis; D015398:Signal Transduction; D013329:Structure-Activity Relationship; D059016:Tumor Microenvironment / Q000235:genetics
chemical_list: D008071:Lipoprotein Lipase
keywords: chronic lymphocytic leukemia; lipid metabolism; lipoprotein lipase; microenvironment; prognosis