title: The Spectrum of Serious Infections Among Patients Receiving Immune Checkpoint Blockade for the Treatment of Melanoma.
abstract: The risk of infection among patients receiving immune checkpoint blockade is unknown. We retrospectively reviewed medical records of 740 patients with melanoma who received immune checkpoint blockers. Serious infection occurred in 54 patients (7.3%). The main risk factors were receipt of corticosteroids and/or infliximab.
authors: Department of Medicine, Jacobi Medical Center, Bronx.
authors: Maria
authors: M
authors: Del Castillo
authors: Department of Medicine, Memorial Sloan Kettering Cancer Center.
authors: Fabian A
authors: FA
authors: Romero
authors: Department of Medicine, Memorial Sloan Kettering Cancer Center.
authors: Esther
authors: E
authors: Argüello
authors: Department of Medicine, Icahn School of Medicine at Mount Sinai, New York.
authors: Chrisann
authors: C
authors: Kyi
authors: Department of Medicine, Memorial Sloan Kettering Cancer Center.
authors: Michael A
authors: MA
authors: Postow
authors: Department of Medicine, Memorial Sloan Kettering Cancer Center.
authors: Gil
authors: G
authors: Redelman-Sidi
mesh_terms: D000293:Adolescent; D000305:Adrenal Cortex Hormones / Q000009:adverse effects* / Q000627:therapeutic use; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000911:Antibodies, Monoclonal / Q000009:adverse effects / Q000627:therapeutic use; D059447:Cell Cycle Checkpoints; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007155:Immunologic Factors / Q000008:administration & dosage / Q000627:therapeutic use*; D007167:Immunotherapy / Q000009:adverse effects; D007239:Infections / Q000453:epidemiology* / Q000209:etiology / Q000382:microbiology / Q000821:virology; D000069285:Infliximab / Q000009:adverse effects* / Q000627:therapeutic use; D008297:Male; D008499:Medical Records; D008545:Melanoma / Q000150:complications* / Q000188:drug therapy* / Q000382:microbiology; D008875:Middle Aged; D012189:Retrospective Studies; D012307:Risk Factors; D055815:Young Adult
chemical_list: D000305:Adrenal Cortex Hormones; D000911:Antibodies, Monoclonal; D007155:Immunologic Factors; D000069285:Infliximab
keywords: checkpoint blockade; immunotherapy; infection; melanoma