title: Mixed gonadal dysgenesis in Yaoundé: A preliminary experience about three cases.
abstract: Mixed gonadal dysgenesis is characterised by unilateral chromosomal abnormality, which is probably the result of anaphase lag during mitosis. The 45, XO/46, XY karyotype is the most common form of mosaicism involving the Y chromosome. It is a rare clinical entity with a worldwide incidence of 1.5/10,000 live births. Its epidemiology in Sub-Saharan Africa is not known. This study reports experience in the management of 3 cases at the Yaounde Gynecologic-Obstetric and Paediatric Hospital. From November 2009 to November 2014, 3 cases were successfully managed at our institution.
  
  
  RESULTS
  All patients presented with asymmetrical gonadal differentiation. On one side of the body, a poorly-developed testicular gonad and on the other side a gonadal streak. A persistent Mόllerian remnant was equally found in the 3 cases. Management of mixed gonadal dysgenesis should be done in tertiary health care centres. A multidisciplinary team approach is recommended.
authors: Pediatric Sugery Service, Gyneco Obstetric and Paediatric Hospital, Yaoundé, Cameroon.
authors: F F
authors: FF
authors: Mouafo Tambo
authors: University Teaching Hospitals of Geneva, Geneva, Switzerland.
authors: S
authors: S
authors: Dahoun
authors: Pediatric Sugery Service, Gyneco Obstetric and Paediatric Hospital, Yaoundé, Cameroon.
authors: C
authors: C
authors: Kamadjou
authors: Pediatric Sugery Service, Gyneco Obstetric and Paediatric Hospital, Yaoundé, Cameroon.
authors: A S
authors: AS
authors: Nwaha Makon
authors: Pediatric Sugery Service, Gyneco Obstetric and Paediatric Hospital, Yaoundé, Cameroon.
authors: G
authors: G
authors: Fossi
authors: Pediatric Sugery Service, Gyneco Obstetric and Paediatric Hospital, Yaoundé, Cameroon.
authors: O G
authors: OG
authors: Andze
authors: Department of Surgery and Subspecialties, Faculty of Medicine and Biomedical Sciences, University of Yaoundé, Yaoundé, Cameroon.
authors: M A
authors: MA
authors: Sosso
authors: Lyon Teaching Hospital, Lyon, France.
authors: P Y
authors: PY
authors: Mure
mesh_terms: D000293:Adolescent; D002163:Cameroon; D002648:Child; D002675:Child, Preschool; D006060:Gonadal Dysgenesis, Mixed / Q000175:diagnosis* / Q000601:surgery*; D006801:Humans; D008297:Male