title: IL-33, Imprimatur of Adipocyte Thermogenesis.
abstract: Chawla and colleagues find that interleukin-33 is a critical controller of brown and beige adipocyte thermogenesis. Its primary impact is on the splicing of transcripts encoding uncoupling protein-1, resulting in uncoupled respiration and effective heat generation. Interleukin-33 acts perinatally to ensure adaptive thermogenesis lifelong.
authors: Division of Immunology, Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA 02115, USA. Electronic address: dm@hms.harvard.edu.
authors: Diane
authors: D
authors: Mathis
mesh_terms: D017667:Adipocytes / Q000378:metabolism; D002001:Adipose Tissue, Brown / Q000378:metabolism*; D006801:Humans; D000067596:Interleukin-33; D007473:Ion Channels; D024101:Mitochondrial Proteins / Q000378:metabolism; D022722:Thermogenesis
chemical_list: D000067596:Interleukin-33; D007473:Ion Channels; D024101:Mitochondrial Proteins