title: Effect of Acute Emotional Stress on Proteomic Profile of Selected Brain Areas and Lysosomal Proteolysis in Rats with Different Behavioral Activity.
abstract: We compared proteome profiles of selected brain areas (cortex, amygdala, hippocampus, and reticular formation) and measured cathepsins B and D activity in liver lysosomal fraction in rats with different behavioral activity under conditions of emotional stress. In passive rats, the expression of some proteins in various brain regions was changed and baseline cathepsin B activity was higher than in active animals. Taken together, the results attest to differences in the adaptive response formation in rats, depending on behavioral features.
authors: Institute of Nutrition of Russian Academy of Medical Sciences, Moscow, Russia. sharanova@ion.ru.
authors: N E
authors: NE
authors: Sharanova
authors: Institute of Nutrition of Russian Academy of Medical Sciences, Moscow, Russia.
authors: N V
authors: NV
authors: Kirbaeva
authors: Human Proteome, Center of Common Use, V. N. Orekhovich Research Institute of Biomedical Chemistry, Moscow, Russia.
authors: I Yu
authors: IY
authors: Toropygin
authors: Human Proteome, Center of Common Use, V. N. Orekhovich Research Institute of Biomedical Chemistry, Moscow, Russia.
authors: E V
authors: EV
authors: Khryapova
authors: P. K. Anokhin Research Institute of Normal Physiology, Moscow, Russia.
authors: E V
authors: EV
authors: Koplik
authors: Institute of Nutrition of Russian Academy of Medical Sciences, Moscow, Russia.
authors: C Kh
authors: CKh
authors: Soto
authors: P. K. Anokhin Research Institute of Normal Physiology, Moscow, Russia.
authors: S S
authors: SS
authors: Pertsov
authors: Institute of Nutrition of Russian Academy of Medical Sciences, Moscow, Russia.
authors: A V
authors: AV
authors: Vasiliev
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism* / Q000502:physiology; D002401:Cathepsin B / Q000378:metabolism; D002402:Cathepsin D / Q000378:metabolism; D006624:Hippocampus / Q000378:metabolism; D008247:Lysosomes / Q000378:metabolism*; D008297:Male; D059748:Proteolysis; D040901:Proteomics; D051381:Rats; D017208:Rats, Wistar; D013315:Stress, Psychological / Q000378:metabolism* / Q000503:physiopathology
chemical_list: D002401:Cathepsin B; D002402:Cathepsin D
keywords: brain; cathepsin B; cathepsin D; emotional stress; proteomics