title: The novelty of phytofurans, isofurans, dihomo-isofurans and neurofurans: Discovery, synthesis and potential application.
abstract: Polyunsaturated fatty acids (PUFA) are oxidized in vivo under oxidative stress through free radical pathway and release cyclic oxygenated metabolites, which are commonly classified as isoprostanes and isofurans. The discovery of isoprostanes goes back twenty-five years compared to fifteen years for isofurans, and great many are discovered. The biosynthesis, the nomenclature, the chemical synthesis of furanoids from α-linolenic acid (ALA, C18:3 n-3), arachidonic acid (AA, C20:4 n-6), adrenic acid (AdA, 22:4 n-6) and docosahexaenoic acid (DHA, 22:6 n-3) as well as their identification and implication in biological systems are highlighted in this review.
authors: Institut des Biomolécules Max Mousseron, UMR 5247 CNRS, Université de Montpellier, ENSCM, Faculté de Pharmacie de Montpellier, 15 Avenue Charles Flahault, Bâtiment D, 34093, Montpellier Cedex 05, France.
authors: Claire
authors: C
authors: Cuyamendous
authors: Institut des Biomolécules Max Mousseron, UMR 5247 CNRS, Université de Montpellier, ENSCM, Faculté de Pharmacie de Montpellier, 15 Avenue Charles Flahault, Bâtiment D, 34093, Montpellier Cedex 05, France.
authors: Aurélien
authors: A
authors: de la Torre
authors: School of Biological Sciences, The University of Hong Kong, Pokfulam Road, Hong Kong Special Administrative Region.
authors: Yiu Yiu
authors: YY
authors: Lee
authors: School of Biological Sciences, The University of Hong Kong, Pokfulam Road, Hong Kong Special Administrative Region.
authors: Kin Sum
authors: KS
authors: Leung
authors: Institut des Biomolécules Max Mousseron, UMR 5247 CNRS, Université de Montpellier, ENSCM, Faculté de Pharmacie de Montpellier, 15 Avenue Charles Flahault, Bâtiment D, 34093, Montpellier Cedex 05, France.
authors: Alexandre
authors: A
authors: Guy
authors: Institut des Biomolécules Max Mousseron, UMR 5247 CNRS, Université de Montpellier, ENSCM, Faculté de Pharmacie de Montpellier, 15 Avenue Charles Flahault, Bâtiment D, 34093, Montpellier Cedex 05, France.
authors: Valérie
authors: V
authors: Bultel-Poncé
authors: Institut des Biomolécules Max Mousseron, UMR 5247 CNRS, Université de Montpellier, ENSCM, Faculté de Pharmacie de Montpellier, 15 Avenue Charles Flahault, Bâtiment D, 34093, Montpellier Cedex 05, France.
authors: Jean-Marie
authors: JM
authors: Galano
authors: School of Biological Sciences, The University of Hong Kong, Pokfulam Road, Hong Kong Special Administrative Region.
authors: Jetty Chung-Yung
authors: JC
authors: Lee
authors: Institut des Biomolécules Max Mousseron, UMR 5247 CNRS, Université de Montpellier, ENSCM, Faculté de Pharmacie de Montpellier, 15 Avenue Charles Flahault, Bâtiment D, 34093, Montpellier Cedex 05, France.
authors: Camille
authors: C
authors: Oger
authors: Institut des Biomolécules Max Mousseron, UMR 5247 CNRS, Université de Montpellier, ENSCM, Faculté de Pharmacie de Montpellier, 15 Avenue Charles Flahault, Bâtiment D, 34093, Montpellier Cedex 05, France. Electronic address: thierry.durand@umontpellier.fr.
authors: Thierry
authors: T
authors: Durand
mesh_terms: D000818:Animals; D016718:Arachidonic Acid / Q000737:chemistry; D004281:Docosahexaenoic Acids / Q000737:chemistry; D005231:Fatty Acids, Unsaturated / Q000737:chemistry*; D005663:Furans / Q000138:chemical synthesis* / Q000737:chemistry*; D006801:Humans; D008956:Models, Chemical; D010084:Oxidation-Reduction; D017962:alpha-Linolenic Acid / Q000737:chemistry
chemical_list: D005231:Fatty Acids, Unsaturated; D005663:Furans; D017962:alpha-Linolenic Acid; C011395:adrenic acid; D004281:Docosahexaenoic Acids; D016718:Arachidonic Acid
keywords: Biomarkers; Dihomo-isofurans; Isofurans; Neurofurans; Phytofurans; Polyunsaturated fatty acids