title: Acquired Immune Deficiency Syndrome in Differential Diagnosis of Hyper-IgE-Immunoglobulinemia: Pediatric Case Report.
abstract: Acquired immune deficiency syndrome can be encountered with hypereosinophilia and hyperimmunoglobulin E (hyper-IgE) values, though these levels are rarely so high to be compared with hyperimmunoglobulin E syndrome. A 9-year-old boy presented with the complaint of fatigue, weakness, weight loss and generalized pruritic rash lasting for a year. He had frequent respiratory tract infections, wheezing episodes and urticarial skin lesions before that. On admission, he was cachectic and he had generalized lymphadenopathy, hepatosplenomegaly, oral moniliasis and pruritic rash all over his body. Laboratory evaluation revealed marked lymphopenia and hypergammaglobulinemia with extremely high IgE values (IgE: 59 300 kU/l). He was diagnosed with stage 4 human immunodeficiency virus (HIV) infection and started on antiretroviral treatment. In conclusion, HIV infection can be presented with increased IgE values.
authors: Pediatric Infectious Diseases and Clinical Immunology, Istanbul University Faculty of Medicine, Istanbul, Turkey.
authors: Manolya
authors: M
authors: Acar
authors: Pediatric Infectious Diseases and Clinical Immunology, Istanbul University Faculty of Medicine, Istanbul, Turkey sutcu13@yahoo.com.
authors: Murat
authors: M
authors: Sutcu
authors: Pediatrics Istanbul, Istanbul University Faculty of Medicine, Istanbul, Turkey.
authors: Ozge
authors: O
authors: Umur
authors: Pediatric Infectious Diseases and Clinical Immunology, Istanbul University Faculty of Medicine, Istanbul, Turkey.
authors: Hacer
authors: H
authors: Akturk
authors: Pediatric Infectious Diseases and Clinical Immunology, Istanbul University Faculty of Medicine, Istanbul, Turkey.
authors: Selda Hancerli
authors: SH
authors: Torun
authors: Pediatric Allergy, Istanbul University Faculty of Medicine, Istanbul, Turkey.
authors: Zeynep
authors: Z
authors: Tamay
authors: Pediatric Infectious Diseases and Clinical Immunology, Istanbul University Faculty of Medicine, Istanbul, Turkey.
authors: Nuran
authors: N
authors: Salman
authors: Pediatric Infectious Diseases and Clinical Immunology, Istanbul University Faculty of Medicine, Istanbul, Turkey.
authors: Ayper
authors: A
authors: Somer
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000175:diagnosis*; D002648:Child; D003937:Diagnosis, Differential; D006801:Humans; D007589:Job Syndrome / Q000175:diagnosis*; D008297:Male
keywords: acquired immune deficiency syndrome; child.; hyperimmunoglobulin E