title: The effect of pregabalin - codeine combination on partial sciatic nerve ligation - induced peripheral mononeuropathy in rats.
abstract: The present study investigates the effects of pregabalin (PGB) and codeine (COD) combination on neuropathic hyperalgesia in an animal model of peripheral nerve injury represented by partial sciatic nerve ligation. Hot plate and analgesimeter tests were performed to evaluate the influence of PGB, COD and their combination on thermal and mechanical hyperalgesia in the hind paw with partial sciatic nerve ligation. Reactivity was evaluated by measuring the latency to withdrawal of the operated hind paw from the noxious heat and pressure stimulation. Nociceptive thresholds were evaluated before (baseline) and in the 1(st), 3(rd), 5(th) and 7(th) day after surgical procedure. The investigation demonstrates that the treatment with PGB attenuated partial sciatic nerve ligation development of thermal and mechanical hyperalgesia in rats operated hind paw. The oral administration, during 14 consecutive days of PGB-COD combination significantly reduced the degree of both thermal and mechanical hyperalgesia in the hind paw with partial sciatic nerve ligation. These results suggest that the association of PGB with COD exerted ameliorative effect on partial sciatic nerve ligation-induced neuropathic pain in rats.
authors: University of Medicine and Pharmacy 'Grigore T. Popa', Faculty of Pharmacy, Department of Pharmaceutical Technology, Iasi, Romania.
authors: G
authors: G
authors: Popa
authors: University of Medicine and Pharmacy 'Grigore T. Popa', Faculty of Medicine, Department of Pharmacology-Algesiology, Iasi, Romania. lylytartau@yahoo.com.
authors: L
authors: L
authors: Mititelu Tartau
authors: University 'Al.I. Cuza', Faculty of Mathematics, Iasi, Romania.
authors: I
authors: I
authors: Stoleriu
authors: University of Medicine and Pharmacy 'Grigore T. Popa', Faculty of Medicine, Department of Patho-Physiology, Iasi, Romania.
authors: R V
authors: RV
authors: Lupusoru
authors: University of Medicine and Pharmacy 'Grigore T. Popa', Faculty of Medicine, Department of Pharmacology-Algesiology, Iasi, Romania.
authors: C E
authors: CE
authors: Lupusoru
authors: University of Medicine and Pharmacy 'Grigore T. Popa', Faculty of Pharmacy, Department of Pharmaceutical Technology, Iasi, Romania.
authors: L
authors: L
authors: Ochiuz
mesh_terms: D000700:Analgesics / Q000627:therapeutic use*; D000818:Animals; D003061:Codeine / Q000627:therapeutic use*; D004338:Drug Combinations; D006358:Hot Temperature / Q000009:adverse effects; D006930:Hyperalgesia / Q000188:drug therapy*; D008026:Ligation; D008297:Male; D020422:Mononeuropathies / Q000188:drug therapy*; D009437:Neuralgia / Q000188:drug therapy*; D010812:Physical Stimulation / Q000009:adverse effects; D000069583:Pregabalin / Q000627:therapeutic use*; D017208:Rats, Wistar; D012584:Sciatic Nerve / Q000601:surgery
chemical_list: D000700:Analgesics; D004338:Drug Combinations; D000069583:Pregabalin; D003061:Codeine