title: The rise of FGF23: should insights from population-based studies inform future clinical trials?
abstract: Research on the potential effects of fibroblast growth factor 23 (FGD23) in chronic kidney disease (CKD) has been galvanized by work suggesting that the FGF23 level rises even before the parathyroid hormone (PTH) level. However, new work suggests that the levels of both FGF23 and PTH may begin to rise much earlier than previously appreciated, indeed well before the establishment of clinically evident CKD. These findings challenge previous understanding and could affect the design of interventional trials designed to lower FGF23 levels.
authors: Division of Nephrology, Hennepin County Medical Center, Chronic Disease Research Group, Minneapolis Medical Research Foundation, Minneapolis, Minnesota, USA. Electronic address: James.Wetmore@hcmed.org.
authors: James B
authors: JB
authors: Wetmore
mesh_terms: D000089703:Fibroblast Growth Factor-23; D005346:Fibroblast Growth Factors; D006801:Humans; D010281:Parathyroid Hormone; D051436:Renal Insufficiency, Chronic
chemical_list: C000717427:FGF23 protein, human; D010281:Parathyroid Hormone; D005346:Fibroblast Growth Factors; D000089703:Fibroblast Growth Factor-23