title: The analysis of scalp irritation by coacervates produced in hair shampoo via FTIR with focal plane array detector, X-ray photoelectron microscopy and HaCaT cells.
abstract: OBJECTIVE
  Coacervates are inevitably formed on scalp on using hair washing products. Our goal was to analyse the coacervates in detail to identify the part responsible for scalp stimulation.
  
  
  METHODS
  Shampoo that increases coacervate formation was applied to in vitro skin and was washed. The residue was then analysed using Fourier transform infrared spectroscopy-focal plane array (FTIR-FPA) and X-ray photoelectron microscopy (XPS). And HaCaT cells were used for irritant test of coacervate.
  
  
  RESULTS
  Through this research, it was confirmed that the coacervate was a macromolecule structurally similar to a cationic polymer and contains an anionic surfactant. Its anionic surfactant was structurally semi-stable so that it released onto scalp when it absorbs moisture.
  
  
  CONCLUSIONS
  Coacervate releases sulphate bonding into the matrix when it is exposed to water. Thus, the scalp stimulation would be expected.
authors: AMOREPACIFIC Research and Development Center, 314-1 Bora-Dong, Yongin-Si, 446-729, South Korea.
authors: I K
authors: IK
authors: Jung
authors: AMOREPACIFIC Research and Development Center, 314-1 Bora-Dong, Yongin-Si, 446-729, South Korea.
authors: S C
authors: SC
authors: Park
authors: AMOREPACIFIC Research and Development Center, 314-1 Bora-Dong, Yongin-Si, 446-729, South Korea.
authors: S H
authors: SH
authors: Kim
authors: AMOREPACIFIC Research and Development Center, 314-1 Bora-Dong, Yongin-Si, 446-729, South Korea.
authors: J H
authors: JH
authors: Kim
authors: AMOREPACIFIC Research and Development Center, 314-1 Bora-Dong, Yongin-Si, 446-729, South Korea.
authors: N R
authors: NR
authors: Cha
authors: AMOREPACIFIC Research and Development Center, 314-1 Bora-Dong, Yongin-Si, 446-729, South Korea.
authors: W R
authors: WR
authors: Bae
authors: AMOREPACIFIC Research and Development Center, 314-1 Bora-Dong, Yongin-Si, 446-729, South Korea.
authors: H N
authors: HN
authors: Kim
authors: AMOREPACIFIC Research and Development Center, 314-1 Bora-Dong, Yongin-Si, 446-729, South Korea.
authors: S A
authors: SA
authors: Cho
authors: AMOREPACIFIC Research and Development Center, 314-1 Bora-Dong, Yongin-Si, 446-729, South Korea.
authors: J W
authors: JW
authors: Yoo
authors: AMOREPACIFIC Research and Development Center, 314-1 Bora-Dong, Yongin-Si, 446-729, South Korea.
authors: B M
authors: BM
authors: Kim
authors: AMOREPACIFIC Research and Development Center, 314-1 Bora-Dong, Yongin-Si, 446-729, South Korea.
authors: J H
authors: JH
authors: Lee
mesh_terms: D002460:Cell Line; D006203:Hair Preparations / Q000737:chemistry*; D006801:Humans; D007509:Irritants / Q000494:pharmacology*; D008853:Microscopy / Q000379:methods*; D012535:Scalp / Q000187:drug effects*; D017550:Spectroscopy, Fourier Transform Infrared / Q000379:methods*
chemical_list: D006203:Hair Preparations; D007509:Irritants
keywords: chemical analysis; focal plane array; hair treatment; spectroscopy