title: Dementia after Three Months and One Year from Stroke: New Onset or Previous Cognitive Impairment?
abstract: OBJECTIVE
  Stroke is an important risk factor for dementia, but the exact mechanism involved in cognitive decline remains unclear.
  
  
  METHODS
  Patients were divided into 2 groups: poststroke dementia group (PSD) and poststroke nondementia group (PSND). Variables and neuroradiological hallmarks were compared between 2 groups at 3 months (114 subjects) and 1 year (105 subjects) after stroke.
  
  
  RESULTS
  Older age (OR 1.11, 95% CI 1.0-1.2; P < .05), education (OR .6, 95% CI .4-.8; P < .05), prestroke IQCODE (Informant Questionnaire on Cognitive Decline in the Elderly; OR .78, 95% CI .1-5.9; P < .05), premorbid apathy (OR 2.03, 95% CI 1.1-3.7; P < .05), and medial temporal lobe atrophy (MTLA) (OR 6.14, 95% CI 1.4-26.2; P < .05) were independently associated with PSD at 3 months after a cerebrovascular event, whereas at 1-year follow-up older age (OR 1.1, 95% CI 1.0-1.2; P < .05), prestroke IQCODE (OR .05, 95% CI .0-.9; P < .05), MTLA (OR 1.3, 95% CI 1.0-1.6; P < .05), and APACHE II (Acute Physiology and Chronic Health Evaluation; OR .6, 95% CI .4-.9; P < .05) were independently associated with PSD.
  
  
  CONCLUSIONS
  Acute cerebrovascular disease could not be the only one mechanism explaining PSD. Neurodegenerative pathology must be taken into account.
authors: Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy. Electronic address: salvatore.caratozzolo@hotmail.com.
authors: Salvatore
authors: S
authors: Caratozzolo
authors: Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy.
authors: Giulia
authors: G
authors: Mombelli
authors: Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy.
authors: Maddalena
authors: M
authors: Riva
authors: Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy.
authors: Marina
authors: M
authors: Zanetti
authors: Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy.
authors: Federica
authors: F
authors: Gottardi
authors: Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy.
authors: Alessandro
authors: A
authors: Padovani
authors: Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy.
authors: Luca
authors: L
authors: Rozzini
mesh_terms: D018806:APACHE; D000368:Aged; D000369:Aged, 80 and over; D057565:Apathy; D016009:Chi-Square Distribution; D003071:Cognition; D003072:Cognition Disorders / Q000175:diagnosis / Q000209:etiology* / Q000523:psychology; D000072226:Computed Tomography Angiography; D015140:Dementia, Vascular / Q000175:diagnosis / Q000209:etiology* / Q000523:psychology; D004185:Disability Evaluation; D005260:Female; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D009410:Nerve Degeneration; D016017:Odds Ratio; D018570:Risk Assessment; D012307:Risk Factors; D020521:Stroke / Q000150:complications* / Q000175:diagnosis / Q000523:psychology; D011795:Surveys and Questionnaires; D013702:Temporal Lobe / Q000000981:diagnostic imaging / Q000473:pathology; D013997:Time Factors
keywords: CT scan measure; Poststroke dementia; apathy; cerebrovascular disease; medial temporal lobe atrophy (MTLA); neurodegenerative dementia; psychobehavioral disturbances