title: The role of progranulin in arthritis.
abstract: Progranulin (PGRN) is a growth factor with a unique beads-on-a-string structure that is involved in multiple pathophysiological processes, including anti-inflammation, tissue repair, wound healing, neurodegenerative diseases, and tumorigenesis. This review presents up-to-date information concerning recent studies on the role of PGRN in inflammatory arthritis and osteoarthritis, with a special focus on the involvement of the interactions and interplay between PGRN and tumor necrosis factor receptor (TNFR) family members in regulating such musculoskeletal diseases. In addition, this paper highlights the applications of atsttrin, an engineered protein comprising three TNFR-binding fragments of PGRN, as a promising intervention in treating arthritis.
authors: Department of Orthopaedic Surgery, New York University Medical Center, New York, New York.|Department of Orthopaedic Surgery, Medical School of Shandong University, Jinan, Shandong, China.
authors: Jianlu
authors: J
authors: Wei
authors: Department of Orthopaedic Surgery, New York University Medical Center, New York, New York.
authors: Aubryanna
authors: A
authors: Hettinghouse
authors: Department of Orthopaedic Surgery, New York University Medical Center, New York, New York.|Department of Cell Biology, New York University School of Medicine, New York, New York.
authors: Chuanju
authors: C
authors: Liu
mesh_terms: D000818:Animals; D001168:Arthritis / Q000188:drug therapy* / Q000378:metabolism*; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000502:physiology* / Q000627:therapeutic use; D000077153:Progranulins; D011485:Protein Binding / Q000502:physiology; D018124:Receptors, Tumor Necrosis Factor / Q000378:metabolism*; D011993:Recombinant Fusion Proteins / Q000378:metabolism / Q000627:therapeutic use; D015398:Signal Transduction / Q000502:physiology; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
chemical_list: C557987:Atsttrin fusion protein; C492314:GRN protein, human; D036341:Intercellular Signaling Peptides and Proteins; D000077153:Progranulins; D018124:Receptors, Tumor Necrosis Factor; D011993:Recombinant Fusion Proteins; D014409:Tumor Necrosis Factor-alpha
keywords: TNFR; arthritis; bone regeneration; progranulin