title: Angiopoietin-2 expression in patients with an acute exacerbation of idiopathic interstitial pneumonias.
abstract: We hypothesized that increased pulmonary vascular permeability may play a role in the pathogenesis of an acute exacerbation of the idiopathic interstitial pneumonias (AE-IIPs). Angiopoietin-2 (Ang-2) promotes endothelial activation, destabilization, and inflammation. The purpose of this study was to examine whether Ang-2 expression was associated with the pathogenesis of AE-IIPs.
  
  
  
  Twenty-three patients with AE-IIP patients, 18 acute lung injury/acute respiratory distress syndrome (ALI/ARDS) patients, 37 idiopathic pulmonary fibrosis (IPF) patients, and 33 healthy volunteers (HVs) were enrolled. The serum level of Ang-2 was measured by an enzyme-linked immunosorbent assay.
  
  
  
  The serum levels of Ang-2 were higher in AE-IIPs and ALI/ARDS patients than in IPF patients and HVs; the BALF levels of Ang-2 were also higher than in IPF patients. There was a positive correlation between the serum level of Ang-2 and the CRP in patients with AE-IIP patients, whereas a significant positive correlation was found between the serum Ang-2 level and the CRP or SOFA scores of the ALI/ARDS patients. Although the baseline Ang-2 level was not related to survival, the Ang-2 levels significantly declined in survivors during treatment, while they did not change in non-survivors.
  
  
  
  Increased pulmonary vascular permeability and inflammation due to Ang-2 may play a role in the pathogenesis of AE-IIPs.
authors: Department of Respiratory Medicine, Oita University Faculty of Medicine, 1-1 Idaigaoka, Hasama-machi, Yufu-shi, Oita, 879-5593, Japan. Electronic address: mando@oita-u.ac.jp.
authors: Masaru
authors: M
authors: Ando
authors: Center for Community Medicine, Oita University Faculty of Medicine, 1-1 Idaigaoka, Hasama-machi, Yufu-shi, Oita, 879-5593, Japan.
authors: Eishi
authors: E
authors: Miyazaki
authors: Internal Medicine 3, Oita University Faculty of Medicine, 1-1 Idaigaoka, Hasama-machi, Yufu-shi, Oita, 879-5593, Japan.
authors: Tetsutaro
authors: T
authors: Abe
authors: Department of Respiratory Medicine, Oita University Faculty of Medicine, 1-1 Idaigaoka, Hasama-machi, Yufu-shi, Oita, 879-5593, Japan.
authors: Chihiro
authors: C
authors: Ehara
authors: Department of Respiratory Medicine, Oita University Faculty of Medicine, 1-1 Idaigaoka, Hasama-machi, Yufu-shi, Oita, 879-5593, Japan.
authors: Akihiro
authors: A
authors: Goto
authors: Department of Respiratory Medicine, Oita University Faculty of Medicine, 1-1 Idaigaoka, Hasama-machi, Yufu-shi, Oita, 879-5593, Japan.
authors: Taiki
authors: T
authors: Masuda
authors: Department of Respiratory Medicine, Oita University Faculty of Medicine, 1-1 Idaigaoka, Hasama-machi, Yufu-shi, Oita, 879-5593, Japan.
authors: Suehiro
authors: S
authors: Nishio
authors: Department of Respiratory Medicine, Oita University Faculty of Medicine, 1-1 Idaigaoka, Hasama-machi, Yufu-shi, Oita, 879-5593, Japan.
authors: Hideaki
authors: H
authors: Fujisaki
authors: Department of Respiratory Medicine, Oita University Faculty of Medicine, 1-1 Idaigaoka, Hasama-machi, Yufu-shi, Oita, 879-5593, Japan.
authors: Mari
authors: M
authors: Yamasue
authors: Center for Community Medicine, Oita University Faculty of Medicine, 1-1 Idaigaoka, Hasama-machi, Yufu-shi, Oita, 879-5593, Japan.
authors: Toshihiro
authors: T
authors: Ishii
authors: Department of Respiratory Medicine, Oita University Faculty of Medicine, 1-1 Idaigaoka, Hasama-machi, Yufu-shi, Oita, 879-5593, Japan.
authors: Yutaka
authors: Y
authors: Mukai
authors: Department of Respiratory Medicine, Oita University Faculty of Medicine, 1-1 Idaigaoka, Hasama-machi, Yufu-shi, Oita, 879-5593, Japan.
authors: Takeo
authors: T
authors: Ito
authors: Department of Respiratory Medicine, Oita University Faculty of Medicine, 1-1 Idaigaoka, Hasama-machi, Yufu-shi, Oita, 879-5593, Japan.
authors: Shin-Ich
authors: SI
authors: Nureki
authors: Internal Medicine 3, Oita University Faculty of Medicine, 1-1 Idaigaoka, Hasama-machi, Yufu-shi, Oita, 879-5593, Japan.
authors: Toshihide
authors: T
authors: Kumamoto
authors: Department of Respiratory Medicine, Oita University Faculty of Medicine, 1-1 Idaigaoka, Hasama-machi, Yufu-shi, Oita, 879-5593, Japan.
authors: Junichi
authors: J
authors: Kadota
mesh_terms: D055371:Acute Lung Injury / Q000097:blood* / Q000503:physiopathology; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D042702:Angiopoietin-2 / Q000097:blood*; D002199:Capillary Permeability / Q000235:genetics; D018450:Disease Progression; D005260:Female; D006801:Humans; D054988:Idiopathic Interstitial Pneumonias / Q000097:blood* / Q000000981:diagnostic imaging / Q000503:physiopathology; D054990:Idiopathic Pulmonary Fibrosis / Q000000981:diagnostic imaging / Q000473:pathology; D007249:Inflammation / Q000378:metabolism; D008168:Lung / Q000098:blood supply / Q000378:metabolism* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D012128:Respiratory Distress Syndrome / Q000097:blood* / Q000503:physiopathology; D012189:Retrospective Studies; D016019:Survival Analysis; D015898:Tomography Scanners, X-Ray Computed
chemical_list: D042702:Angiopoietin-2
keywords: Acute exacerbation of idiopathic interstitial pneumonias (AE-IIPs); Acute lung injury/acute respiratory distress syndrome (ALI/ARDS); Angiopoietin-2