title: Evaluation of a novel in-line point-of-care blood gas analyser.
abstract: Point-of-care testing is becoming increasingly relevant to the practice of anaesthesia and critical care medicine, especially in terms of minimisation of sample volumes and decreased time to decision making. We performed a prospective observational study to evaluate a novel, in-line blood gas analysis device against a conventional benchtop model, and assessed it while placing the enrolled patients under extreme physiological conditions, specifically deep hypothermic circulatory arrest. Eight patients were studied, and had between seven and 11 samples analysed for seven variables (pH, pCO2 , pO2 , HCO3 (-) , base excess [BE], K(+) and haematocrit [Hct]), using the device during the process of cooling to 20 °C on cardiopulmonary bypass, and subsequent rewarming to normothermia. After Passing-Bablok analysis, the variables were evaluated for bias, limits of agreement and percentage error at above and below 30 °C. Of the measured variables, only pH (percentage error 2.4%) and potassium (19.8%) demonstrated acceptable (< 30%) percentage error over the full range of temperatures measured. Carbon dioxide, when stratified by temperature, was acceptable (< 30 °C percentage error 24.6%, > 30 °C percentage error 9.9%), but the overall percentage error of the dataset (45.8%) was excessively high. Bicarbonate and haematocrit both had an acceptable percentage error above 30 °C (25.2% and 18.5%, respectively), but similar to carbon dioxide, percentage error for the full range of temperatures exceeded 30%. These data differ from previous work examining this device, and highlights the difference between derived measures using different apparatuses when exposed to extreme physiological conditions.
authors: Department of Anaesthesia and Intensive Care, Papworth Hospital, Cambridge, UK.
authors: L F
authors: LF
authors: Miles
authors: Department of Research and Development, Papworth Hospital, Cambridge, UK.
authors: K
authors: K
authors: Giraud
authors: Department of Cardiothoracic Surgery, Papworth Hospital, Cambridge, UK.
authors: R
authors: R
authors: Ferris
authors: Department of Anaesthesia and Intensive Care, Papworth Hospital, Cambridge, UK.
authors: A A
authors: AA
authors: Klein
authors: Department of Anaesthesia and Intensive Care, Papworth Hospital, Cambridge, UK.
authors: G C
authors: GC
authors: Martinez
authors: Department of Cardiothoracic Surgery, Papworth Hospital, Cambridge, UK.
authors: D P
authors: DP
authors: Jenkins
authors: Department of Anaesthesia and Intensive Care, Papworth Hospital, Cambridge, UK.
authors: K
authors: K
authors: Saulankey
mesh_terms: D001784:Blood Gas Analysis; D002315:Cardiopulmonary Bypass; D006801:Humans; D006863:Hydrogen-Ion Concentration; D019095:Point-of-Care Systems; D011446:Prospective Studies; D017694:Rewarming
keywords: ABG values: measured vs. calculated; deep hypothermic circulatory arrest; hypothermia: pH-stat management; point-of-care testing