title: Bacterial corneal ulcer associated with common variable immune deficiency.
abstract: Common variable immune deficiency (CVID) is one of the most commonly diagnosed primary immunodeficiencies. Generally, patients have a history of recurrent sinopulmonary infections, hypogammaglobulinemia of two or more immunoglobulin isotypes, and impaired functional antibody responses. Reports of corneal involvement associated with CVID are limited. We describe a case of corneal ulceration associated with methicillin-resistant Staphylococcus aureus in a patient with CVID that developed while on monthly intravenous immunoglobulin infusions and in which there were no common risk factors for bacterial keratitis, such as prior history of ocular surface disease, trichiasis, trauma, or contact lens wear.
authors: Department of Ophthalmology, New York University School of Medicine, New York, NY, USA.|Department of Surgery, Dartmouth-Hitchcock Medical Center, Lebanon, NH, USA.
authors: Edmund
authors: http://orcid.org/0000-0001-7532-9191
authors: E
authors: Tsui
authors: Geisel School of Medicine at Dartmouth, Hanover, NH, USA.
authors: Jie
authors: J
authors: Deng
authors: Geisel School of Medicine at Dartmouth, Hanover, NH, USA.
authors: Andrew N
authors: AN
authors: Siedlecki
authors: Geisel School of Medicine at Dartmouth, Hanover, NH, USA. Michael.E.Zegans@dartmouth.edu.|Section of Ophthalmology, Dartmouth-Hitchcock Medical Center, 1 Medical Center Drive, Lebanon, NH, 03756, USA. Michael.E.Zegans@dartmouth.edu.
authors: Michael E
authors: ME
authors: Zegans
keywords: Autoimmune disease; Bacterial keratitis; Common variable immunodeficiency; Immunosuppression