title: Effect of hydration status on atrial and ventricular volumes and function in healthy adult volunteers.
abstract: BACKGROUND
  Assessment of cardiac chamber volumes is a fundamental part of cardiac magnetic resonance (CMR) imaging. While the effects of inter- and intraobserver variability have been studied and have a recognized effect on the comparability of serial cardiac MR imaging studies, the effect of differences in hydration status has not been evaluated.
  
  
  OBJECTIVE
  To evaluate the effects of volume administration on cardiac chamber volumes.
  
  
  METHODS
  Thirteen healthy adults underwent a baseline cardiac MR to evaluate cardiac chamber volumes after an overnight fast. They were then given two saline boluses of 10 ml/kg of body weight and the cardiac MR was repeated immediately after each bolus.
  
  
  RESULTS
  From the baseline scan to the final scan there was a significant increase in all four cardiac chamber end-diastolic volumes. Right atrial volumes increased 8.0%, from 61.1 to 66.0 ml/m2 (P<0.001), and left atrial volumes increased 10.0%, from 50.0 to 55.0 ml/m2 (P<0.001). Right ventricular volumes increased 6.0%, from 91.1 to 96.5 ml/m2 (P<0.001), and left ventricular volumes increased 3.2%, from 87.0 to 89.8 ml/m2 (P<0.001).
  
  
  CONCLUSIONS
  Hydration status has a significant effect on the end-diastolic volumes of all cardiac chambers assessed by cardiac MR. Thus, hydration represents a "variable" that should be taken into account when assessing cardiac chamber volumes, especially when performing serial imaging studies in a patient.
authors: The Labatt Family Heart Centre in the Department of Paediatrics, The Hospital for Sick Children, 555 University Ave., Toronto, ON, M5G 1X8, Canada. dschantz@hsc.mb.ca.|Variety Children's Heart Centre, University of Manitoba, FE241-685 William Avenue, Winnipeg, MB, Canada. dschantz@hsc.mb.ca.
authors: Daryl I
authors: DI
authors: Schantz
authors: The Labatt Family Heart Centre in the Department of Paediatrics, The Hospital for Sick Children, 555 University Ave., Toronto, ON, M5G 1X8, Canada.
authors: Andreea
authors: A
authors: Dragulescu
authors: Department of Radiology, St. Boniface General Hospital, University of Manitoba, Winnipeg, MB, Canada.
authors: Brett
authors: B
authors: Memauri
authors: The Labatt Family Heart Centre in the Department of Paediatrics, The Hospital for Sick Children, 555 University Ave., Toronto, ON, M5G 1X8, Canada.|Wilhelmina Children's Hospital, Utrecht, The Netherlands.
authors: Heynric B
authors: HB
authors: Grotenhuis
authors: The Labatt Family Heart Centre in the Department of Paediatrics, The Hospital for Sick Children, 555 University Ave., Toronto, ON, M5G 1X8, Canada.|Department of Diagnostic Imaging, The Hospital for Sick Children, Toronto, ON, Canada.
authors: Mike
authors: M
authors: Seed
authors: The Labatt Family Heart Centre in the Department of Paediatrics, The Hospital for Sick Children, 555 University Ave., Toronto, ON, M5G 1X8, Canada.|Department of Diagnostic Imaging, The Hospital for Sick Children, Toronto, ON, Canada.
authors: Lars
authors: L
authors: Grosse-Wortmann
mesh_terms: D000328:Adult; D016275:Atrial Function / Q000502:physiology*; D002306:Cardiac Volume; D003971:Diastole; D005215:Fasting; D005260:Female; D064368:Healthy Volunteers; D006325:Heart Atria / Q000000981:diagnostic imaging*; D006352:Heart Ventricles / Q000000981:diagnostic imaging*; D006801:Humans; D019028:Magnetic Resonance Imaging, Cine; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012965:Sodium Chloride / Q000008:administration & dosage*; D016276:Ventricular Function / Q000502:physiology*
chemical_list: D012965:Sodium Chloride
keywords: Adult; Cardiac function; Cardiac magnetic resonance; Cardiac volume; Heart; Hydration; Preload