title: Preferential Cancer Cell Self-Recognition and Tumor Self-Targeting by Coating Nanoparticles with Homotypic Cancer Cell Membranes.
abstract: The ultimate goal in cancer therapy and diagnosis is to achieve highly specific targeting to cancer cells. Coated with the source cancer cell membrane specifically derived from the homologous tumors, the nanoparticles are identified with the self-recognition internalization by the source cancer cell lines in vitro and the highly tumor-selective targeting "homing" to the homologous tumor in vivo even in the competition of another heterologous tumor. As the result, MNP@DOX@CCCM nanovehicle showed strong potency for tumor treatment in vivo and the MR imaging. This bioinspired strategy shows great potential for precise therapy/diagnosis of various tumors merely by adjusting the cell membrane source accordingly on the nanoparticle surface.
authors: Key Laboratory of Biomedical Polymers of Ministry of Education & Department of Chemistry, Wuhan University , Wuhan 430072, P. R. China.
authors: Jing-Yi
authors: JY
authors: Zhu
authors: Key Laboratory of Biomedical Polymers of Ministry of Education & Department of Chemistry, Wuhan University , Wuhan 430072, P. R. China.
authors: Di-Wei
authors: DW
authors: Zheng
authors: Key Laboratory of Biomedical Polymers of Ministry of Education & Department of Chemistry, Wuhan University , Wuhan 430072, P. R. China.
authors: Ming-Kang
authors: MK
authors: Zhang
authors: Key Laboratory of Biomedical Polymers of Ministry of Education & Department of Chemistry, Wuhan University , Wuhan 430072, P. R. China.
authors: Wu-Yang
authors: WY
authors: Yu
authors: Key Laboratory of Biomedical Polymers of Ministry of Education & Department of Chemistry, Wuhan University , Wuhan 430072, P. R. China.
authors: Wen-Xiu
authors: WX
authors: Qiu
authors: Key Laboratory of Biomedical Polymers of Ministry of Education & Department of Chemistry, Wuhan University , Wuhan 430072, P. R. China.
authors: Jing-Jing
authors: JJ
authors: Hu
authors: Key Laboratory of Biomedical Polymers of Ministry of Education & Department of Chemistry, Wuhan University , Wuhan 430072, P. R. China.
authors: Jun
authors: J
authors: Feng
authors: Key Laboratory of Biomedical Polymers of Ministry of Education & Department of Chemistry, Wuhan University , Wuhan 430072, P. R. China.
authors: Xian-Zheng
authors: XZ
authors: Zhang
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D002462:Cell Membrane / Q000737:chemistry*; D004317:Doxorubicin / Q000008:administration & dosage / Q000737:chemistry; D016503:Drug Delivery Systems; D005290:Ferric Compounds / Q000737:chemistry; D006801:Humans; D008279:Magnetic Resonance Imaging; D008280:Magnetics; D051379:Mice; D053758:Nanoparticles; D009369:Neoplasms / Q000188:drug therapy
chemical_list: D005290:Ferric Compounds; C000499:ferric oxide; D004317:Doxorubicin
keywords: MRI; Tumor self-targeting (TST); cancer cell membrane; cancer cell self-recognition; magnetic iron oxide