title: Componential Network for the Recognition of Tool-Associated Actions: Evidence from Voxel-based Lesion-Symptom Mapping in Acute Stroke Patients.
abstract: The study aimed to elucidate areas involved in recognizing tool-associated actions, and to characterize the relationship between recognition and active performance of tool use.We performed voxel-based lesion-symptom mapping in a prospective cohort of 98 acute left-hemisphere ischemic stroke patients (68 male, age mean ± standard deviation, 65 ± 13 years; examination 4.4 ± 2 days post-stroke). In a video-based test, patients distinguished correct tool-related actions from actions with spatio-temporal (incorrect grip, kinematics, or tool orientation) or conceptual errors (incorrect tool-recipient matching, e.g., spreading jam on toast with a paintbrush). Moreover, spatio-temporal and conceptual errors were determined during actual tool use.Deficient spatio-temporal error discrimination followed lesions within a dorsal network in which the inferior parietal lobule (IPL) and the lateral temporal cortex (sLTC) were specifically relevant for assessing functional hand postures and kinematics, respectively. Conversely, impaired recognition of conceptual errors resulted from damage to ventral stream regions including anterior temporal lobe. Furthermore, LTC and IPL lesions impacted differently on action recognition and active tool use, respectively.In summary, recognition of tool-associated actions relies on a componential network. Our study particularly highlights the dissociable roles of LTC and IPL for the recognition of action kinematics and functional hand postures, respectively.
authors: Department of Neurology and Clinical Neurosciences, Medical Center, University of Freiburg, 79106 Freiburg im Breisgau, Germany.|Freiburg Brain Imaging Center, University of Freiburg, 79106 Freiburg im Breisgau, Germany.|BrainLinks-BrainTools Cluster of Excellence, University of Freiburg, 79110 Freiburg im Breisgau, Germany.
authors: Markus
authors: M
authors: Martin
authors: Department of Neurology and Clinical Neurosciences, Medical Center, University of Freiburg, 79106 Freiburg im Breisgau, Germany.|Freiburg Brain Imaging Center, University of Freiburg, 79106 Freiburg im Breisgau, Germany.|BrainLinks-BrainTools Cluster of Excellence, University of Freiburg, 79110 Freiburg im Breisgau, Germany.
authors: Andrea
authors: A
authors: Dressing
authors: Department of Neurology and Clinical Neurosciences, Medical Center, University of Freiburg, 79106 Freiburg im Breisgau, Germany.|Freiburg Brain Imaging Center, University of Freiburg, 79106 Freiburg im Breisgau, Germany.
authors: Tobias
authors: T
authors: Bormann
authors: Department of Neurology and Clinical Neurosciences, Medical Center, University of Freiburg, 79106 Freiburg im Breisgau, Germany.|Freiburg Brain Imaging Center, University of Freiburg, 79106 Freiburg im Breisgau, Germany.|BrainLinks-BrainTools Cluster of Excellence, University of Freiburg, 79110 Freiburg im Breisgau, Germany.
authors: Charlotte S M
authors: CSM
authors: Schmidt
authors: Department of Neurology and Clinical Neurosciences, Medical Center, University of Freiburg, 79106 Freiburg im Breisgau, Germany.|Freiburg Brain Imaging Center, University of Freiburg, 79106 Freiburg im Breisgau, Germany.
authors: Dorothee
authors: D
authors: Kümmerer
authors: Department of Neurology and Clinical Neurosciences, Medical Center, University of Freiburg, 79106 Freiburg im Breisgau, Germany.|Freiburg Brain Imaging Center, University of Freiburg, 79106 Freiburg im Breisgau, Germany.|BrainLinks-BrainTools Cluster of Excellence, University of Freiburg, 79110 Freiburg im Breisgau, Germany.
authors: Lena
authors: L
authors: Beume
authors: Language and Aphasia Laboratory, Department of Neurology, Medical Center, University of Leipzig, 04103 Leipzig, Germany.
authors: Dorothee
authors: D
authors: Saur
authors: BrainLinks-BrainTools Cluster of Excellence, University of Freiburg, 79110 Freiburg im Breisgau, Germany.|Department of Neuroradiology, Medical Center, University of Freiburg, 79106 Freiburg im Breisgau, Germany.
authors: Irina
authors: I
authors: Mader
authors: Department of Neurology and Clinical Neurosciences, Medical Center, University of Freiburg, 79106 Freiburg im Breisgau, Germany.|Freiburg Brain Imaging Center, University of Freiburg, 79106 Freiburg im Breisgau, Germany.
authors: Michel
authors: M
authors: Rijntjes
authors: Department of Neurology and Clinical Neurosciences, Medical Center, University of Freiburg, 79106 Freiburg im Breisgau, Germany.|Freiburg Brain Imaging Center, University of Freiburg, 79106 Freiburg im Breisgau, Germany.|BrainLinks-BrainTools Cluster of Excellence, University of Freiburg, 79110 Freiburg im Breisgau, Germany.
authors: Christoph P
authors: CP
authors: Kaller
authors: Department of Neurology and Clinical Neurosciences, Medical Center, University of Freiburg, 79106 Freiburg im Breisgau, Germany.|Freiburg Brain Imaging Center, University of Freiburg, 79106 Freiburg im Breisgau, Germany.|BrainLinks-BrainTools Cluster of Excellence, University of Freiburg, 79110 Freiburg im Breisgau, Germany.
authors: Cornelius
authors: C
authors: Weiller
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001072:Apraxias / Q000000981:diagnostic imaging / Q000209:etiology / Q000503:physiopathology / Q000523:psychology; D001921:Brain / Q000000981:diagnostic imaging / Q000503:physiopathology*; D002545:Brain Ischemia / Q000000981:diagnostic imaging / Q000503:physiopathology* / Q000523:psychology; D005260:Female; D006225:Hand / Q000503:physiopathology; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009039:Motion Perception / Q000502:physiology*; D009048:Motor Skills / Q000502:physiology*; D009483:Neuropsychological Tests; D011446:Prospective Studies; D021641:Recognition, Psychology / Q000502:physiology*; D020521:Stroke / Q000000981:diagnostic imaging / Q000503:physiopathology* / Q000523:psychology; D055815:Young Adult
keywords: VLSM; action recognition; apraxia; stroke; tool use