title: Serum uric acid change and modification of blood pressure and fasting plasma glucose in an overall healthy population sample: data from the Brisighella heart study.
abstract: Serum uric acid (SUA) is an emerging risk factor for incident hypertension and type 2 diabetes. It is less clear if changes in SUA are associated to different incidence in these main cardiovascular risk factors.
  
  
  
  From the cohort of the Brisighella Heart Study, we selected non-diabetic subjects that in 2008 were untreated with SUA-lowering drugs nor antihypertensive ones. Then we divided the subjects in four main groups: the ones that maintained their SUA level unchanged during the next 4 years, the ones that increased it >1 mg/dL without treatment, the ones that reduced it >1 mg/dL without drug treatment and the ones that reduced it >1 mg/dL with the continuous use of allopurinol.
  
  
  
  Compared with 2008, SBP significantly increased in subjects with worsened (and untreated) SUA level, while improved in subjects treated with allopurinol (p < 0.05). In 2012, subjects with worsened (and untreated) SUA level had a significantly higher SBP compared with subjects with unchanged SUA and those with SUA improved after allopurinol treatment (p < 0.05). An identical trend has been observed as it regards FPG.
  
  
  
  It seems that SUA improvement could positively influence the age-related worsening of SBP and FPG in general population. Key messages Serum uric acid (SUA) is an emerging risk factor for incident hypertension and type 2 diabetes. SUA improvement could positively influence the age-related worsening of SBP and FPG in general population.
authors: a Department of Medical and Surgical Sciences , University of Bologna , Bologna , Italy.
authors: Arrigo F G
authors: AF
authors: Cicero
authors: a Department of Medical and Surgical Sciences , University of Bologna , Bologna , Italy.
authors: Martina
authors: M
authors: Rosticci
authors: a Department of Medical and Surgical Sciences , University of Bologna , Bologna , Italy.
authors: Marilisa
authors: M
authors: Bove
authors: a Department of Medical and Surgical Sciences , University of Bologna , Bologna , Italy.
authors: Federica
authors: F
authors: Fogacci
authors: a Department of Medical and Surgical Sciences , University of Bologna , Bologna , Italy.
authors: Marina
authors: M
authors: Giovannini
authors: a Department of Medical and Surgical Sciences , University of Bologna , Bologna , Italy.
authors: Riccardo
authors: R
authors: Urso
authors: a Department of Medical and Surgical Sciences , University of Bologna , Bologna , Italy.
authors: Sergio
authors: S
authors: D'Addato
authors: a Department of Medical and Surgical Sciences , University of Bologna , Bologna , Italy.
authors: Claudio
authors: C
authors: Borghi
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D001786:Blood Glucose / Q000378:metabolism*; D001794:Blood Pressure / Q000502:physiology*; D003924:Diabetes Mellitus, Type 2 / Q000453:epidemiology; D005215:Fasting / Q000097:blood*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000453:epidemiology; D015994:Incidence; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D014527:Uric Acid / Q000097:blood*; D055815:Young Adult
chemical_list: D001786:Blood Glucose; D014527:Uric Acid
keywords: Blood pressure; epidemiology; fasting plasma glucose; population study; serum uric acid