title: Biology of Saccular Cerebral Aneurysms: A Review of Current Understanding and Future Directions.
abstract: Understanding the biology of intracranial aneurysms is a clinical quandary. How these aneurysms form, progress, and rupture is poorly understood. Evidence indicates that well-established risk factors play a critical role, along with immunologic factors, in their development and clinical outcomes. Much of the expanding knowledge of the inception, progression, and rupture of intracranial aneurysms implicates inflammation as a critical mediator of aneurysm pathogenesis. Thus, therapeutic targets exploiting this arm of aneurysm pathogenesis have been implemented, often with promising outcomes.
authors: Department of Neurosurgery, Barrow Neurological Institute, St. Joseph's Hospital and Medical Center , Phoenix, AZ , USA.
authors: Vernard S
authors: VS
authors: Fennell
authors: Department of Neurosurgery, Barrow Neurological Institute, St. Joseph's Hospital and Medical Center , Phoenix, AZ , USA.
authors: M Yashar S
authors: MY
authors: Kalani
authors: Department of Neurosurgery, Barrow Neurological Institute, St. Joseph's Hospital and Medical Center , Phoenix, AZ , USA.
authors: Gursant
authors: G
authors: Atwal
authors: Department of Neurosurgery, Barrow Neurological Institute, St. Joseph's Hospital and Medical Center , Phoenix, AZ , USA.
authors: Nikolay L
authors: NL
authors: Martirosyan
authors: Department of Neurosurgery, Barrow Neurological Institute, St. Joseph's Hospital and Medical Center , Phoenix, AZ , USA.
authors: Robert F
authors: RF
authors: Spetzler
keywords: biology; inflammation; intracranial aneurysm