title: Status epilepticus alters hippocampal long-term synaptic potentiation in a rat lithium-pilocarpine model.
abstract: Seizure-induced memory deficits are frequent in patients with temporal lobe epilepsy. However, the neural mechanisms responsible for this memory impairment are not entirely clear. Persistent changes in synaptic efficacy, long-term potentiation (LTP), and depression are considered a cellular substrate underlying the learning and memory processes. Using a lithium-pilocarpine model to induce status epilepticus (SE) in rats, the present study investigated whether the induction of LTP was altered in hippocampal slices obtained 3 h, 1, 3, and 7 days after SE. One week after SE, LTP induction was decreased in hippocampal slices. The reduced plasticity in post-SE tissue was attributable to N-methyl-D-aspartate receptor-dependent LTP. In contrast to control tissue, ifenprodil, a GluN2B-selective antagonist, did not reduce the LTP level in post-SE tissue, suggesting that SE disturbs the functional properties of GluN2B-containing N-methyl-D-aspartate receptors. These changes in synaptic transmission may contribute toward the genesis of epilepsy and seizure-associated memory deficits.
authors: aSechenov Institute of Evolutionary Physiology and Biochemistry of the Russian Academy of Sciences (IEPhB) bDepartment of Medicine, Saint Petersburg State University, Saint Petersburg, Russia.
authors: Kirill A
authors: KA
authors: Kryukov
authors: Kira K
authors: KK
authors: Kim
authors: Lev G
authors: LG
authors: Magazanik
authors: Aleksey V
authors: AV
authors: Zaitsev
mesh_terms: D015763:2-Amino-5-phosphonovalerate / Q000627:therapeutic use; D000818:Animals; D000927:Anticonvulsants / Q000627:therapeutic use; D003292:Convulsants / Q000633:toxicity*; D004195:Disease Models, Animal; D006624:Hippocampus / Q000187:drug effects*; D066298:In Vitro Techniques; D008094:Lithium / Q000633:toxicity*; D017774:Long-Term Potentiation / Q000187:drug effects*; D018408:Patch-Clamp Techniques; D010862:Pilocarpine / Q000633:toxicity*; D051381:Rats; D017208:Rats, Wistar; D013226:Status Epilepticus / Q000139:chemically induced* / Q000473:pathology / Q000517:prevention & control; D013997:Time Factors
chemical_list: D000927:Anticonvulsants; D003292:Convulsants; D010862:Pilocarpine; D015763:2-Amino-5-phosphonovalerate; D008094:Lithium