title: MYC/BCL2 Double-hit Lymphoma in a Patient with Rheumatoid Arthritis Associated with Methotrexate Treatment.
abstract: Several reports have suggested an increased risk of malignant lymphoma in patients with rheumatoid arthritis treated with methotrexate (MTX). We herein describe the case of a 71-year-old woman with rheumatoid arthritis who developed MYC/BCL2 double-hit lymphoma associated with MTX therapy. She developed a fever and lymphadenopathies over a 2-week period and had elevated levels of soluble IL-2 receptor. Inguinal lymph node and bone marrow biopsies showed diffuse large B cell lymphoma. Fluorescent in situ hybridization revealed MYC and BCL2 gene rearrangements in her lymphoma cells. Accordingly, a diagnosis of MYC/BCL2 double-hit lymphoma was made. This is the first reported case of a double-hit lymphoma associated with MTX therapy.
authors: Department of Hematology, Chiba Aoba Municipal Hospital, Japan.
authors: Ryota
authors: R
authors: Kurimoto
authors: Katsuhiro
authors: K
authors: Shono
authors: Masahiro
authors: M
authors: Onoda
authors: Kyohei
authors: K
authors: Yamamoto
authors: Akira
authors: A
authors: Yokota
mesh_terms: D000368:Aged; D018501:Antirheumatic Agents / Q000008:administration & dosage / Q000009:adverse effects*; D001172:Arthritis, Rheumatoid / Q000188:drug therapy; D005260:Female; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D016403:Lymphoma, Large B-Cell, Diffuse / Q000139:chemically induced* / Q000175:diagnosis* / Q000473:pathology; D008727:Methotrexate / Q000008:administration & dosage / Q000009:adverse effects*; D015375:Receptors, Interleukin-2
chemical_list: D018501:Antirheumatic Agents; D015375:Receptors, Interleukin-2; D008727:Methotrexate