title: Multidimensional vocal assessment after laser treatment for recurrent respiratory papillomatosis.
abstract: Recurrent respiratory papillomatosis (RRP) is a benign epithelial tumor that exhibits a high frequency of recurrence. This study assesses the vocal function after laser treatment for RRP, particularly in relation to the frequency of surgery.
  
  
  
  Retrospective study.
  
  
  
  Thirty RRP patients who underwent laser surgery that controlled the tumor were included. Preoperative and postoperative Grade, Roughness, Breathiness, Asthenia, and Strain Scale, videostroboscopic findings, aerodynamic and acoustic parameters, and self-assessment questionnaires were measured and compared with an age- and sex-matched control group. Subsequently, to evaluate the association between postoperative voice quality and the number of surgeries, the patients were divided into three groups (group 1: single surgery, group 2: 2-5 surgeries, group3: >6 surgeries), and comparative multidimensional vocal assessments were performed.
  
  
  
  The mean number of surgeries was 3.4 (range, 1-8). Although all patients exhibited poorer vocal function than the control group preoperatively, they showed improvement in postoperative subjective and objective parameters. However, four patients who underwent one surgery with relatively aggressive ablation exhibited vocal cord scarring and deteriorated objective parameters. All remaining patients showed voice quality that was on par with the control group. Subgroup analysis proved no association between post-therapeutic voice quality and the patient characteristics, including preoperative staging and the number of surgical treatments performed.
  
  
  
  RRP patients can achieve a close to normal voice with high satisfaction even after recurrent surgical treatment when ablation of a subepithelial lesion using sufficient laser energy is adequate.
  
  
  
  3b Laryngoscope, 127:679-684, 2017.
authors: Department of Otolaryngology-Head and Neck Surgery, Keio University School of Medicine, Tokyo, Japan.
authors: Takeyuki
authors: T
authors: Kono
authors: Department of Otolaryngology-Head and Neck Surgery, Keio University School of Medicine, Tokyo, Japan.
authors: Haruna
authors: H
authors: Yabe
authors: Department of Otolaryngology-Head and Neck Surgery, Keio University School of Medicine, Tokyo, Japan.
authors: Kosuke
authors: K
authors: Uno
authors: Department of Otolaryngology-Head and Neck Surgery, Kyorin University School of Medicine, Tokyo, Japan.
authors: Koichiro
authors: K
authors: Saito
authors: Department of Otolaryngology-Head and Neck Surgery, Keio University School of Medicine, Tokyo, Japan.
authors: Kaoru
authors: K
authors: Ogawa
mesh_terms: D000328:Adult; D001707:Biopsy, Needle; D016022:Case-Control Studies; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007150:Immunohistochemistry; D053685:Laser Therapy / Q000379:methods*; D008297:Male; D008875:Middle Aged; D008991:Monitoring, Physiologic / Q000379:methods; D030361:Papillomavirus Infections / Q000473:pathology* / Q000601:surgery*; D011182:Postoperative Care / Q000379:methods; D020127:Recovery of Function; D012016:Reference Values; D012141:Respiratory Tract Infections / Q000473:pathology* / Q000601:surgery*; D012189:Retrospective Studies; D057566:Self Report; D012720:Severity of Illness Index; D013997:Time Factors; D016896:Treatment Outcome; D014827:Vocal Cords / Q000473:pathology / Q000601:surgery*; D014833:Voice Quality
keywords: Recurrent respiratory papillomatosis; laser surgery; multidimensional assessment; number of surgeries; vocal function