title: Ventricular premature contraction associated with mitral valve prolapse.
abstract: BACKGROUND
  In patients with frequent premature ventricular contractions (PVCs), little is known about the profile of PVCs and the outcome of treatment in patients with mitral valve prolapse (MVP) compared to those without MVP.
  
  
  RESULTS
  Patients with documented PVCs between January 2001 and October 2012 were divided into 2 groups: MVP and non-MVP. The PVC characteristics, efficacy of therapy, and outcome were compared between the 2 groups. A total of 112 patients with MVP and 952 without MVP were identified. The frequency of PVCs was similar between the 2 groups (P>.05). In patients who underwent cardiac mapping, PVCs originating in papillary muscles (26.7% vs 2.3%; P<.001) and fascicle (13.3% vs 3.4%; P<.001) were more frequently seen in the MVP group than in the non-MVP group, which raises the difficulty of catheter ablation. The 2 groups had similar response to catheter ablation or medical therapy (P>.05). The survival rate was similar between the 2 groups (P=.95).
  
  
  CONCLUSIONS
  In patients with significant PVC burden, MVP patients had similar PVC frequency, treatment outcome, and survival rate to those without MVP.
authors: Department of Cardiology, Chinese PLA General Hospital, Beijing 100853, China.
authors: Hong-TaoYuan
authors: Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN 55905, USA.
authors: Mei
authors: M
authors: Yang
authors: Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN 55905, USA.
authors: Li
authors: L
authors: Zhong
authors: Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN 55905, USA.
authors: Ying-Hsiang
authors: YH
authors: Lee
authors: Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN 55905, USA.
authors: Vaibhav R
authors: VR
authors: Vaidya
authors: Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN 55905, USA.
authors: Samuel J
authors: SJ
authors: Asirvatham
authors: Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN 55905, USA.
authors: Michael J
authors: MJ
authors: Ackerman
authors: Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN 55905, USA.
authors: Sorin V
authors: SV
authors: Pislaru
authors: Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN 55905, USA.
authors: Rakesh M
authors: RM
authors: Suri
authors: Department of Health Sciences Research, Mayo Clinic, Rochester, MN 55905, USA.
authors: Joshua P
authors: JP
authors: Slusser
authors: Department of Health Sciences, Research, Mayo Clinic, Jacksonville, FL 32224, USA.
authors: David O
authors: DO
authors: Hodge
authors: Department of Cardiology, Chinese PLA General Hospital, Beijing 100853, China. Electronic address: wyt301@sina.com.
authors: Yu-Tang
authors: YT
authors: Wang
authors: Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN 55905, USA. Electronic address: ycha@mayo.edu.
authors: Yong-Mei
authors: YM
authors: Cha
mesh_terms: D000368:Aged; D000889:Anti-Arrhythmia Agents / Q000627:therapeutic use*; D017115:Catheter Ablation / Q000379:methods*; D019468:Disease Management; D004452:Echocardiography / Q000379:methods; D015716:Electrocardiography, Ambulatory / Q000379:methods; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008945:Mitral Valve Prolapse / Q000150:complications / Q000175:diagnosis / Q000401:mortality / Q000503:physiopathology; D012189:Retrospective Studies; D016896:Treatment Outcome; D014481:United States; D018879:Ventricular Premature Complexes / Q000175:diagnosis / Q000209:etiology / Q000503:physiopathology
chemical_list: D000889:Anti-Arrhythmia Agents
keywords: Antiarrhythmic drug; Mitral valve prolapse; Premature ventricular contraction; Radiofrequency catheter ablation