title: IL-22 mediates the oral mucosal wound healing via STAT3 in keratinocytes.
abstract: OBJECTIVE
  Wounds are common in the oral cavity. During wound healing, several cytokines are released, which are probably helpful in providing wound debridement, removal of damaged tissues and microbes. Most of the target cells of IL-22 are epithelial cells, which play an important role in mucosa immunity.
  
  
  METHODS
  The function of IL-22 in oral diseases is not well understood. We investigated the expression level of IL-22, collagen I and p-stat3 (Tyr705) via a mice tongue wound model in vivo and detected the effect of IL-22 on the expression of MMP-1, type I collagen and p-stat3 in keratinocytes.
  
  
  RESULTS
  IL-22 and p-stat3 were associated with wound healing, and STAT3 was activated when the keratinocytes or the tongue tissue were stimulated by IL-22. In addition, IL-22 could mediate gene expression involved in wounds involving keratinocytes, such as type I collagen and MMP-1, which may contribute to scarless healing.
  
  
  CONCLUSIONS
  Our study suggests that IL-22 mediates wound healing via STAT3 in keratinocytes. This study reveals a new role for IL-22 in mediating wound healing.
authors: Department of Stomatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 430022 Wuhan, China.
authors: Ran
authors: R
authors: Yu
authors: Department of Stomatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 430022 Wuhan, China.
authors: Yumei
authors: Y
authors: Ding
authors: Department of Stomatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 430022 Wuhan, China.
authors: Lijuan
authors: L
authors: Zhu
authors: Dalian Stomatological Hospital of Dalian Medical University, 116021 Dalian, China.
authors: Yinying
authors: Y
authors: Qu
authors: Department of Stomatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 430022 Wuhan, China.
authors: Chenguang
authors: C
authors: Zhang
authors: Dalian Stomatological Hospital of Dalian Medical University, 116021 Dalian, China. Electronic address: 305802104@qq.com.
authors: Lin
authors: L
authors: Liu
authors: Department of Stomatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 430022 Wuhan, China. Electronic address: chenlili@whuh.com.
authors: Lili
authors: L
authors: Chen
mesh_terms: D000818:Animals; D015153:Blotting, Western; D002465:Cell Movement / Q000502:physiology; D049109:Cell Proliferation / Q000502:physiology; D024042:Collagen Type I / Q000378:metabolism; D004195:Disease Models, Animal; D004591:Electrophoresis, Polyacrylamide Gel; D005347:Fibroblasts / Q000502:physiology; D007150:Immunohistochemistry; D007378:Interleukins / Q000502:physiology*; D015603:Keratinocytes / Q000502:physiology*; D020781:Matrix Metalloproteinase 1 / Q000378:metabolism; D051379:Mice; D060888:Real-Time Polymerase Chain Reaction; D050796:STAT3 Transcription Factor / Q000502:physiology*; D014059:Tongue / Q000293:injuries*; D014945:Wound Healing / Q000502:physiology*; D000097043:Interleukin-22
chemical_list: D024042:Collagen Type I; D007378:Interleukins; D020781:Matrix Metalloproteinase 1; D050796:STAT3 Transcription Factor; D000097043:Interleukin-22
keywords: IL-22; STAT3; Wound healing