title: Wounds that heal and wounds that don't - The role of the IL-33/ST2 pathway in tissue repair and tumorigenesis.
abstract: IL-33 is a member of the IL-1 family of cytokines. IL-33 is predominantly located within the nucleus of cells where it plays a role in gene regulation. Given the right combination of signals and cellular damage, stored IL-33 is released from the cell where it can interact with its receptor ST2, triggering danger-associated responses and act as a cellular "alarmin". Whilst IL-33/ST2 signalling has been shown to induce potent pro-inflammatory responses that can be detrimental in certain disease states, a dichotomous, protective role of IL-33 in promoting wound healing has also emerged in multiple tissues types. This review will explore the current literature concerning this homeostatic role of IL-33/ST2 in tissue repair and also review its role in uncontrolled wound responses as seen in both fibrosis and tumorigenesis.
authors: Institute of Infection, Immunity and Inflammation. College of Medicine, Veterinary and Life Sciences, University Of Glasgow, Glasgow, United Kingdom.
authors: Neal L
authors: NL
authors: Millar
authors: Dept. of Pathology, University College Cork, National University of Ireland, Ireland.
authors: Charlotte
authors: C
authors: O'Donnell
authors: Institute of Infection, Immunity and Inflammation. College of Medicine, Veterinary and Life Sciences, University Of Glasgow, Glasgow, United Kingdom.
authors: Iain B
authors: IB
authors: McInnes
authors: Dept. of Pathology, University College Cork, National University of Ireland, Ireland; APC Microbiome Institute, University College Cork, National University of Ireland, Ireland. Electronic address: e.brint@ucc.ie.
authors: Elizabeth
authors: E
authors: Brint
mesh_terms: D000818:Animals; D063646:Carcinogenesis / Q000378:metabolism* / Q000473:pathology*; D006801:Humans; D000067596:Interleukin-33 / Q000378:metabolism*; D018919:Neovascularization, Physiologic; D017472:Receptors, Interleukin-1 / Q000378:metabolism*; D015398:Signal Transduction; D014945:Wound Healing
chemical_list: D000067596:Interleukin-33; D017472:Receptors, Interleukin-1
keywords: Fibrosis; Interleukin 33; ST2; Tissue damage; Tumorigenesis