title: Impact of chemotherapy on the outcome of osteosarcoma of the head and neck in adults.
abstract: There is an ongoing debate about the value of (neo-)adjuvant chemotherapy in high- and intermediate-grade osteosarcoma of the head and neck.
  
  
  
  All records of patients older than 16 years diagnosed with osteosarcoma of the head and neck in the Netherlands between 1993 and 2013 were reviewed.
  
  
  
  We identified a total of 77 patients with an osteosarcoma of the head and neck; the 5-year overall survival (OS) was 55%. In 50 patients with surgically resected high- or intermediate-grade osteosarcoma of the head and neck younger than 75 years, univariate and multivariable analysis, adjusting for age and resection margins, showed that patients who had not received chemotherapy had a significantly higher risk of local recurrence (hazard ratio [HR] = 3.78 and 3.66, respectively).
  
  
  
  In patients younger than 75 years of age with surgically resected high- and intermediate-grade osteosarcoma of the head and neck, treatment with (neo-)adjuvant chemotherapy resulted in a significantly smaller risk of local recurrence. Therefore, we suggest (neo-)adjuvant chemotherapy in patients amenable to chemotherapy. © 2016 The Authors Head & Neck Published by Wiley Periodicals, Inc. Head Neck 39: 140-146, 2017.
authors: Department of Medical Oncology, Radboud University Medical Center, Nijmegen, The Netherlands.
authors: Eline
authors: E
authors: Boon
authors: Department of Medical Oncology, Radboud University Medical Center, Nijmegen, The Netherlands.|The Institute of Cancer Research and the Royal Marsden NHS Foundation Trust, London, United Kingdom.
authors: Winette T A
authors: WT
authors: van der Graaf
authors: Department of Medical Oncology, Leiden University Medical Center, Leiden, The Netherlands.
authors: Hans
authors: H
authors: Gelderblom
authors: Department of Medical Oncology, Antoni van Leeuwenhoek Hospital/Netherlands Cancer Institute, Amsterdam, The Netherlands.
authors: Margot E T
authors: ME
authors: Tesselaar
authors: Department of Head and Neck Surgical Oncology, University Medical Center Utrecht, Utrecht, The Netherlands.
authors: Robert J J
authors: RJ
authors: van Es
authors: University of Groningen, Department of Medical Oncology, University Medical Center Groningen, Groningen, The Netherlands.
authors: Sjoukje F
authors: SF
authors: Oosting
authors: Department of Head and Neck Surgical Oncology, University Medical Center Utrecht, Utrecht, The Netherlands.|Department of Otolaryngology-Head and Neck Surgery, VU University Medical Center, Amsterdam, The Netherlands.
authors: Remco
authors: R
authors: de Bree
authors: Department of Medical Oncology, Erasmus Medical Center Cancer Institute, Erasmus University Medical Center Rotterdam, The Netherlands.
authors: Esther
authors: E
authors: van Meerten
authors: Department of Medical Oncology, Maastricht University Medical Center, Maastricht, The Netherlands.
authors: Ann
authors: A
authors: Hoeben
authors: Department of Head and Neck Oncology and Surgery, Antoni van Leeuwenhoek Hospital/Netherlands Cancer Institute, Amsterdam, The Netherlands.
authors: Ludi E
authors: LE
authors: Smeele
authors: Department of Pathology, University Medical Center Utrecht, Utrecht, The Netherlands.
authors: Stefan M
authors: SM
authors: Willems
authors: University of Groningen, Department of Oral and Maxillofacial Surgery, University Medical Center Groningen, Groningen, The Netherlands.
authors: Max J H
authors: MJ
authors: Witjes
authors: Department of Medical Oncology, VU University Medical Center, Amsterdam, The Netherlands.
authors: Jan
authors: J
authors: Buter
authors: Department of Otorhinolaryngology/Head and Neck Surgery, Erasmus University Medical Center, Rotterdam, The Netherlands.
authors: Robert J
authors: RJ
authors: Baatenburg de Jong
authors: Department of Pathology, Radboud University Medical Center, Nijmegen, The Netherlands.
authors: Uta E
authors: UE
authors: Flucke
authors: Radboud Institute for Health Sciences, Biostatistics, Radboud University Medical Center, Nijmegen, The Netherlands.
authors: Petronella G M
authors: PG
authors: Peer
authors: Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands.
authors: Judith V M G
authors: JV
authors: Bovée
authors: Department of Medical Oncology, Radboud University Medical Center, Nijmegen, The Netherlands.
authors: Carla M L
authors: CM
authors: Van Herpen
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D017024:Chemotherapy, Adjuvant; D005260:Female; D006258:Head and Neck Neoplasms / Q000188:drug therapy* / Q000401:mortality / Q000601:surgery*; D006801:Humans; D008297:Male; D008875:Middle Aged; D020360:Neoadjuvant Therapy; D009364:Neoplasm Recurrence, Local / Q000453:epidemiology*; D009426:Netherlands; D012516:Osteosarcoma / Q000188:drug therapy* / Q000401:mortality / Q000601:surgery*; D012189:Retrospective Studies; D015996:Survival Rate; D055815:Young Adult
keywords: (neo-)adjuvant; chemotherapy; head and neck neoplasms; mandible; maxilla; osteosarcoma