title: High Prevalence of Carbapenemase-Producing Enterobacteriaceae among Hospitalized Children in Luanda, Angola.
abstract: This study aimed to evaluate the prevalence of carbapenemase-producing Enterobacteriaceae in Luanda, Angola. A total of 157 rectal samples were collected from children visiting a pediatric hospital in Luanda in March 2015. Fifty-seven imipenem-nonsusceptible enterobacterial isolates were recovered, most of which were non-clonally related. The blaOXA-181 (50/57) and blaNDM-1 (7/57) carbapenemase genes were identified. Notably, OXA-181-producing Escherichia coli isolates rarely coproduced extended-spectrum β-lactamases and consequently remained susceptible to broad-spectrum cephalosporins. The blaOXA-181 gene was always located on an IncX3 plasmid, while the blaNDM-1 gene was located on either IncFIA or IncA/C plasmids. The study identified a high prevalence of OXA-181 among hospitalized children in Angola.
authors: Emerging Antibiotic Resistance Unit, Medical and Molecular Microbiology, Department of Medicine, University of Fribourg, Fribourg, Switzerland INSERM European Unit (LEA, Paris, France), University of Fribourg, Fribourg, Switzerland.
authors: Nicolas
authors: N
authors: Kieffer
authors: Emerging Antibiotic Resistance Unit, Medical and Molecular Microbiology, Department of Medicine, University of Fribourg, Fribourg, Switzerland INSERM European Unit (LEA, Paris, France), University of Fribourg, Fribourg, Switzerland University of Lausanne and University Hospital Center, Lausanne, Switzerland.
authors: Patrice
authors: P
authors: Nordmann
authors: Escola Superior de Saúde da Cruz Vermelha Portuguesa (ESSCVP), Lisbon, Portugal.
authors: Marta
authors: M
authors: Aires-de-Sousa
authors: Emerging Antibiotic Resistance Unit, Medical and Molecular Microbiology, Department of Medicine, University of Fribourg, Fribourg, Switzerland INSERM European Unit (LEA, Paris, France), University of Fribourg, Fribourg, Switzerland laurent.poirel@unifr.ch.
authors: Laurent
authors: L
authors: Poirel
mesh_terms: D000293:Adolescent; D000810:Angola / Q000453:epidemiology; D001426:Bacterial Proteins / Q000235:genetics* / Q000378:metabolism; D002648:Child; D002675:Child, Preschool; D016521:Electrophoresis, Gel, Pulsed-Field; D004755:Enterobacteriaceae / Q000235:genetics* / Q000302:isolation & purification; D004756:Enterobacteriaceae Infections / Q000453:epidemiology / Q000382:microbiology*; D029968:Escherichia coli Proteins / Q000235:genetics; D005243:Feces / Q000382:microbiology; D006761:Hospitals; D006801:Humans; D007223:Infant; D001618:beta-Lactamases / Q000235:genetics* / Q000378:metabolism
chemical_list: D001426:Bacterial Proteins; D029968:Escherichia coli Proteins; D001618:beta-Lactamases; C552864:beta-lactamase NDM-1; C000607154:beta-lactamase OXA-181, E coli; C063912:carbapenemase