title: The conversion of fibrinogen to fibrin: A brief history of some key events.
abstract: The conversion of fibrinogen to fibrin is a process that has long fascinated an army of researchers. In this brief review some early break-through observations are noted and a few later unexpected results described.
authors: Department of Chemistry & Biochemistry, University of California, San Diego, La Jolla, CA 92093-0314, USA; Department of Molecular Biology, University of California, San Diego, La Jolla, CA 92093-0314, USA. Electronic address: rdoolittle@ucsd.edu.
authors: Russell F
authors: RF
authors: Doolittle
mesh_terms: D000818:Animals; D001777:Blood Coagulation / Q000502:physiology*; D002938:Ciona intestinalis / Q000737:chemistry / Q000502:physiology; D005176:Factor XIII / Q000737:chemistry / Q000266:history / Q000378:metabolism*; D005337:Fibrin / Q000737:chemistry / Q000266:history / Q000378:metabolism*; D005340:Fibrinogen / Q000737:chemistry / Q000266:history / Q000378:metabolism*; D049673:History, 20th Century; D049674:History, 21st Century; D006801:Humans; D008958:Models, Molecular; D044367:Phase Transition; D059748:Proteolysis; D055672:Static Electricity; D013917:Thrombin / Q000737:chemistry / Q000266:history / Q000378:metabolism*
chemical_list: D005337:Fibrin; D005340:Fibrinogen; D005176:Factor XIII; D013917:Thrombin
keywords: Factor XIII; Fibrin; Fibrinogen; Papain; Protofibrinogen; Thrombin