title: IMP-27, a Unique Metallo-β-Lactamase Identified in Geographically Distinct Isolates of Proteus mirabilis.
abstract: A novel metallo-β-lactamase gene, blaIMP-27, was identified in unrelated Proteus mirabilis isolates from two geographically distinct locations in the United States. Both isolates harbor blaIMP-27 as part of the first gene cassette in a class 2 integron. Antimicrobial susceptibility testing indicated susceptibility to aztreonam, piperacillin-tazobactam, and ceftazidime but resistance to ertapenem. However, hydrolysis assays indicated that ceftazidime was a substrate for IMP-27.
authors: Creighton University School of Medicine, Department of Medical Microbiology and Immunology, Center for Research in Anti-Infectives and Biotechnology, Omaha, Nebraska, USA.
authors: Nyssa
authors: N
authors: Dixon
authors: Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, Nebraska, USA.
authors: Randal C
authors: RC
authors: Fowler
authors: School of Medical Technology, Gumma Paz College, Takasakishi, Gumma, Japan.
authors: A
authors: A
authors: Yoshizumi
authors: Shionogi & Co., Ltd., Osaka, Japan.
authors: Tsukasa
authors: T
authors: Horiyama
authors: Toho University School of Medicine, Department of Microbiology and Infectious Diseases, Tokyo, Japan.
authors: Y
authors: Y
authors: Ishii
authors: Creighton University School of Medicine, Department of Medical Microbiology and Immunology, Center for Research in Anti-Infectives and Biotechnology, Omaha, Nebraska, USA.
authors: Lucas
authors: L
authors: Harrison
authors: Creighton University School of Medicine, Department of Medical Microbiology and Immunology, Center for Research in Anti-Infectives and Biotechnology, Omaha, Nebraska, USA.
authors: Chelsie N
authors: CN
authors: Geyer
authors: CHI Health, Omaha, Nebraska, USA.
authors: Ellen Smith
authors: ES
authors: Moland
authors: University of Louisville School of Medicine, Louisville, Kentucky, USA.
authors: Kenneth
authors: K
authors: Thomson
authors: Creighton University School of Medicine, Department of Medical Microbiology and Immunology, Center for Research in Anti-Infectives and Biotechnology, Omaha, Nebraska, USA ndhanson@creighton.edu.
authors: Nancy D
authors: ND
authors: Hanson
mesh_terms: D001398:Aztreonam / Q000494:pharmacology; D002442:Ceftazidime / Q000493:pharmacokinetics; D024881:Drug Resistance, Bacterial / Q000187:drug effects / Q000235:genetics; D000077727:Ertapenem; D006868:Hydrolysis; D032023:Integrons; D008826:Microbial Sensitivity Tests; D010397:Penicillanic Acid / Q000031:analogs & derivatives / Q000494:pharmacology; D010878:Piperacillin / Q000494:pharmacology; D000077725:Piperacillin, Tazobactam Drug Combination; D011512:Proteus Infections / Q000382:microbiology; D011513:Proteus mirabilis / Q000187:drug effects* / Q000235:genetics* / Q000302:isolation & purification; D014481:United States; D001618:beta-Lactamases / Q000235:genetics* / Q000378:metabolism; D047090:beta-Lactams / Q000494:pharmacology
chemical_list: D047090:beta-Lactams; D000077725:Piperacillin, Tazobactam Drug Combination; D010397:Penicillanic Acid; D002442:Ceftazidime; D001618:beta-Lactamases; D001398:Aztreonam; D000077727:Ertapenem; D010878:Piperacillin