title: Histological response of soda-lime glass-ceramic bactericidal rods implanted in the jaws of beagle dogs.
abstract: Bacterial and fungal infections remain a major clinical challenge. Implant infections very often require complicated revision procedures that are troublesome to patients and costly to the healthcare system. Innovative approaches to tackle infections are urgently needed. We investigated the histological response of novel free P2O5 glass-ceramic rods implanted in the jaws of beagle dogs. Due to the particular percolated morphology of this glass-ceramic, the dissolution of the rods in the animal body environment and the immature bone formation during the fourth months of implantation maintained the integrity of the glass-ceramic rod. No clinical signs of inflammation took place in any of the beagle dogs during the four months of implantation. This new glass-ceramic biomaterial with inherent bactericidal and fungicidal properties can be considered as an appealing candidate for bone tissue engineering.
authors: Nanomaterials and Nanotechnology Research Center (CINN), CSIC - University of Oviedo (UO), Avda de la Vega 4-6, El Entrego 33940, San Martín del Rey Aurelio, Spain.|Institute of Materials Science of Madrid (ICMM-CSIC), Cantoblanco, 28049, Madrid, Spain.
authors: José S
authors: JS
authors: Moya
authors: Galician Institute of Ceramics, University of Santiago de Compostela, Avda Maestro Mateo, 15782 Santiago de Compostela, Spain.
authors: Arturo
authors: A
authors: Martínez
authors: Nanomaterials and Nanotechnology Research Center (CINN), CSIC - University of Oviedo (UO), Avda de la Vega 4-6, El Entrego 33940, San Martín del Rey Aurelio, Spain.
authors: Roberto
authors: R
authors: López-Píriz
authors: Galician Institute of Ceramics, University of Santiago de Compostela, Avda Maestro Mateo, 15782 Santiago de Compostela, Spain.
authors: Francisco
authors: F
authors: Guitián
authors: Nanomaterials and Nanotechnology Research Center (CINN), CSIC - University of Oviedo (UO), Avda de la Vega 4-6, El Entrego 33940, San Martín del Rey Aurelio, Spain.
authors: Luis A
authors: LA
authors: Díaz
authors: Institute of Materials Science of Madrid (ICMM-CSIC), Cantoblanco, 28049, Madrid, Spain.
authors: Leticia
authors: L
authors: Esteban-Tejeda
authors: Nanomaterials and Nanotechnology Research Center (CINN), CSIC - University of Oviedo (UO), Avda de la Vega 4-6, El Entrego 33940, San Martín del Rey Aurelio, Spain.
authors: Belén
authors: B
authors: Cabal
authors: IMDEA Materials Institute, C/ Eric Kandel 2, Getafe, 28906, Madrid, Spain.
authors: Federico
authors: F
authors: Sket
authors: Nanomaterials and Nanotechnology Research Center (CINN), CSIC - University of Oviedo (UO), Avda de la Vega 4-6, El Entrego 33940, San Martín del Rey Aurelio, Spain.
authors: Elisa
authors: E
authors: Fernández-García
authors: Materials Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA.
authors: Antoni P
authors: AP
authors: Tomsia
authors: Nanomaterials and Nanotechnology Research Center (CINN), CSIC - University of Oviedo (UO), Avda de la Vega 4-6, El Entrego 33940, San Martín del Rey Aurelio, Spain.
authors: Ramón
authors: R
authors: Torrecillas
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry*; D001672:Biocompatible Materials / Q000737:chemistry / Q000494:pharmacology; D017610:Calcium Compounds / Q000737:chemistry*; D002516:Ceramics / Q000737:chemistry*; D004285:Dogs; D007568:Jaw / Q000473:pathology*; D008855:Microscopy, Electron, Scanning; D056948:Orthognathic Surgical Procedures; D016348:Osseointegration / Q000187:drug effects; D010087:Oxides / Q000737:chemistry*; D016062:Porosity; D019736:Prostheses and Implants / Q000662:veterinary; D012972:Sodium Hydroxide / Q000737:chemistry*; D013052:Spectrometry, X-Ray Emission; D014057:Tomography, X-Ray Computed
chemical_list: D000900:Anti-Bacterial Agents; D001672:Biocompatible Materials; D017610:Calcium Compounds; D010087:Oxides; C004569:soda lime; D012972:Sodium Hydroxide; C023506:Glass ceramics