title: Phenotypic characterization of a pair of molecules in tissues confer to classical Mendelian or non Mendelian ratios.
abstract: Studies have reported a wide range of inflammatory responses in the nerve, skin and plasma of leprosy patients. The expression levels of each biomolecule was individualistic, however could be categorized as high and low based on their statistical mean level. Here we report for the first time, expression of a set of biomolecules relating with each other in a defined proportion. The hypothesis of this paper is that the segregation of high and low combinations of a set of biomolecules follows either classical Mendelian dihybrid ratio or epistatic ratios. This hypothesis was tested for 17 molecules in three tissues; nerve, skin and plasma and were confirmed to interact in 9:7, 9:3:4, 12:3:1, 13:3, 15:1 epistatic proportions. These findings suggest that there could be a significant role of networking of molecules in defined epistatic proportions and could be important in pathophysiology of peripheral nerve.
authors: CODEWEL Nireekshana ACET, Narayanaguda, Hyderabad 500029, India. Electronic address: drlavanyasuneetha@gmail.com.
authors: L M
authors: LM
authors: Suneetha
authors: CODEWEL Nireekshana ACET, Narayanaguda, Hyderabad 500029, India.
authors: Prasanna
authors: P
authors: Marsakatla
authors: CODEWEL Nireekshana ACET, Narayanaguda, Hyderabad 500029, India.
authors: G V
authors: GV
authors: Ravi
authors: CODEWEL Nireekshana ACET, Narayanaguda, Hyderabad 500029, India.
authors: Aparna
authors: A
authors: Sykam
authors: CODEWEL Nireekshana ACET, Narayanaguda, Hyderabad 500029, India.
authors: R
authors: R
authors: Raju
authors: Mahavir Medical Research Center, 37/165 BhagwanMahavir Marg, AC Guards, Masab Tank, Hyderabad 500028, India.
authors: P P
authors: PP
authors: Reddy
authors: Dept of Statistics, Osmania University, Hyderabad, India.
authors: V V
authors: VV
authors: Hara Gopal
authors: Government Institute of Science, Mumbai, India.
authors: R
authors: R
authors: Jadhav
authors: CODEWEL Nireekshana ACET, Narayanaguda, Hyderabad 500029, India.
authors: S
authors: S
authors: Suneetha
mesh_terms: D000465:Algorithms; D000942:Antigens, Bacterial / Q000276:immunology; D004843:Epistasis, Genetic; D005808:Genes, Recessive; D006801:Humans; D007249:Inflammation / Q000235:genetics* / Q000276:immunology; D007918:Leprosy / Q000235:genetics / Q000276:immunology / Q000473:pathology*; D008957:Models, Genetic; D015233:Models, Statistical; D009474:Neurons / Q000378:metabolism; D010525:Peripheral Nerves / Q000503:physiopathology; D010641:Phenotype; D010949:Plasma / Q000378:metabolism; D012189:Retrospective Studies; D012867:Skin / Q000378:metabolism; D016896:Treatment Outcome
chemical_list: D000942:Antigens, Bacterial
keywords: Bimolecular interactions; CD68; Ceramide; Epistasis; LAM; Leprosy; Nerve; PGL; Plasma; S100; Skin; TGF; TNF; iNOS