title: Association between MKL1 rs6001946 and schizophrenia in a Han Chinese population.
abstract: Megakaryoblastic leukemia 1 (MKL1) is highly expressed in the nervous system and plays a potentially principal role in neuronal migration and morphology. A recent study showed that some genetic loci within the MKL1 gene, especially single nucleotide polymorphism (SNP) rs6001946, may increase schizophrenia susceptibility. Here, we sought to determine whether the polymorphism rs6001946 was associated with schizophrenia in a Han Chinese population using the ligase detection reaction-polymerase chain reaction method to genotype SNP rs6001946 in the MKL1 gene. We observed that there was a marginally significant association between SNP rs6001946 and the risk of schizophrenia (P=0.077). Our results indicated that SNP rs6001946 of the MKL1 gene is likely a risk factor for schizophrenia, but the role of SNP rs6001946 in the development of schizophrenia in Han Chinese should be interpreted cautiously. Further studies with larger sample sizes are needed to determine the involvement of the MKL1 polymorphism in schizophrenia susceptibility.
authors: Wuxi Mental Health Center, Nanjing Medical University, Wuxi, 214151, Jiangsu Province, China.
authors: Dong
authors: D
authors: Wang
authors: Wuxi Mental Health Center, Nanjing Medical University, Wuxi, 214151, Jiangsu Province, China.
authors: Zaohuo
authors: Z
authors: Cheng
authors: Wuxi Mental Health Center, Nanjing Medical University, Wuxi, 214151, Jiangsu Province, China.
authors: Xingfu
authors: X
authors: Zhao
authors: Institute of Mental Health of the second Xiangya hospital, National Laboratory for Psychiatry Disease Diagnosis and Treatment, Key Laboratory of Psychiatry and Mental Health of Hunan Province, The Central South University, Changsha, China.
authors: Zongchang
authors: Z
authors: Li
authors: Wuxi Mental Health Center, Nanjing Medical University, Wuxi, 214151, Jiangsu Province, China.
authors: Jun
authors: J
authors: Wang
authors: Wuxi Mental Health Center, Nanjing Medical University, Wuxi, 214151, Jiangsu Province, China.
authors: Aiguo
authors: A
authors: Dong
authors: Wuxi Mental Health Center, Nanjing Medical University, Wuxi, 214151, Jiangsu Province, China.
authors: Zhenhe
authors: Z
authors: Zhou
authors: Wuxi Mental Health Center, Nanjing Medical University, Wuxi, 214151, Jiangsu Province, China. Electronic address: zhangfq@njmu.edu.cn.
authors: Fuquan
authors: F
authors: Zhang
mesh_terms: D000328:Adult; D044466:Asian People / Q000235:genetics*; D002681:China; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D012559:Schizophrenia / Q000235:genetics*; D015534:Trans-Activators / Q000235:genetics*
chemical_list: C431575:MRTFA protein, human; D015534:Trans-Activators
keywords: MKL1; Schizophrenia; Single nucleotide polymorphism; rs6001946