title: Does the intraocular pressure-lowering effect of prostaglandin analogues continue over the long term?
abstract: The purpose of the study is to assess the changes in the long-term effects of prostaglandin analogues (PGAs) on intraocular pressure (IOP) reduction in patients with primary open-angle glaucoma (POAG). Data of POAG patients treated with latanoprost (0.005 %), travoprost (0.004 %), or bimatoprost (0.03 %) as the first line treatment for 5 years or more were retrospectively evaluated. Baseline ophthalmic assessment values were recorded together with the IOP at the 6th month, 1st year, and then annually. The 79 patients included 33 (41.8 %) men and 46 (58.2 %) women. There were 34 (43.0 %) patients using latanoprost (0.005 %), 23 (29.1 %) patients using bimatoprost (0.03 %), and 22 (27.8 %) patients using travoprost (0.004 %). There was no difference between the groups in terms of age, gender, or baseline IOP levels. IOP levels at the 6th month were significantly lower than baseline IOP levels in all groups (p < 0.01, Friedman test). The IOP decrease was maintained after the 6th month in all three group with no statistically significant difference compared to the 6th month IOP value (p > 0.05, Friedman test) and no statistically significant difference between the groups during follow-up (Kruskal-Wallis test, p > 0.05). IOP reductions with PGAs were adequate and stable in the 5-year follow-up period with no decrease in effectiveness over time.
authors: Department of Ophthalmology, Etlik Zubeyde Hanim Women's Health Education and Research Hospital, Yeni Etlik Caddesi No: 55, Etlik, Keçiören, 06010, Ankara, Turkey. canerkara@hotmail.com.
authors: Caner
authors: http://orcid.org/0000-0002-3628-547X
authors: C
authors: Kara
authors: Ulucanlar Eye Research and Training Hospital, Ankara, Turkey.
authors: Emine Malkoç
authors: EM
authors: Şen
authors: Ulucanlar Eye Research and Training Hospital, Ankara, Turkey.
authors: Kadriye Ufuk
authors: KU
authors: Elgin
authors: Department of Ophthalmology, Ankara Numune Training and Research Hospital, Ankara, Turkey.
authors: Kurtuluş
authors: K
authors: Serdar
authors: Ulucanlar Eye Research and Training Hospital, Ankara, Turkey.
authors: Pelin
authors: P
authors: Yilmazbaş
mesh_terms: D000959:Antihypertensive Agents / Q000008:administration & dosage; D000069580:Bimatoprost / Q000008:administration & dosage*; D005260:Female; D005500:Follow-Up Studies; D005902:Glaucoma, Open-Angle / Q000188:drug therapy* / Q000503:physiopathology; D006068:Gonioscopy; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects*; D000077338:Latanoprost; D008297:Male; D008875:Middle Aged; D009883:Ophthalmic Solutions; D009887:Ophthalmoscopy; D011461:Prostaglandins F, Synthetic / Q000008:administration & dosage; D011465:Prostaglandins, Synthetic / Q000008:administration & dosage*; D012189:Retrospective Studies; D013997:Time Factors; D014065:Tonometry, Ocular; D000069557:Travoprost / Q000008:administration & dosage; D016896:Treatment Outcome
chemical_list: D000959:Antihypertensive Agents; D009883:Ophthalmic Solutions; D011461:Prostaglandins F, Synthetic; D011465:Prostaglandins, Synthetic; D000077338:Latanoprost; D000069580:Bimatoprost; D000069557:Travoprost
keywords: Effect; Glaucoma; Intraocular pressure; Long term; Prostaglandin analogues