title: Application of diffusion-weighted imaging and dynamic susceptibility contrast perfusion-weighted imaging for ganglioglioma in adults: Comparison study with oligodendroglioma.
abstract: OBJECTIVE
  To evaluate diffusion-weighted imaging (DWI) and dynamic susceptibility contrast perfusion-weighted imaging (DSC-PWI) of ganglioglioma (GG) compared with oligodendroglioma (ODG).
  
  
  METHODS
  We enrolled 36 patients with histopathologically confirmed GG (12 patients) or ODG (24 patients). The volumetric analyses of normalized ADC (nADC) and normalized CBV (nCBV) maps, tumor volume, and ratio of enhancing portion compared to the tumor volume were performed. The microvessel area (MVA) was analyzed by staining with the CD34 monoclonal antibody.
  
  
  RESULTS
  GGs occurred more frequently in the temporal lobe than in the frontal lobe. GGs showed a smaller tumor volume, and higher ratio of enhancing portion per tumor volume than ODGs (P=.002, and P=.010, respectively). GGs also showed lower nADC values (1.055±0.063 vs 1.204±0.030, P=.021) and higher nCBV values (0.777±0.032 vs 0.514±0.025, P<.001) than ODGs. Among the parameters in the multivariate model, nCBV was the most significant factor for differentiating GGs and ODGs (P<.0001). GGs showed significantly higher MVAs than ODGs (0.48±0.09 vs 0.24±0.04, P=.025).
  
  
  CONCLUSIONS
  Our results suggest that GGs tend to have relatively smaller tumor volume with higher ratio of enhancing portions, lower nADC values, and higher nCBV values than ODGs. Among these parameters, measurement of nCBV, which is correlated with a higher MVA measurement in GGs, can be the most useful tool for differentiating GGs from ODGs.
authors: Department of Radiology, Seoul National University Hospital, 110-744 Seoul, Republic of Korea.
authors: Seunghyun
authors: S
authors: Lee
authors: Department of Radiology, Seoul National University Hospital, 110-744 Seoul, Republic of Korea; Institute of Radiation Medicine, Seoul National University Medical Research Center, 110-744 Seoul, Republic of Korea.
authors: Tae Jin
authors: TJ
authors: Yun
authors: Department of Radiology, Seoul National University Hospital, 110-744 Seoul, Republic of Korea.
authors: Koung Mi
authors: KM
authors: Kang
authors: Department of Radiology, Seoul National University Hospital, 110-744 Seoul, Republic of Korea.
authors: Jung Hyo
authors: JH
authors: Rhim
authors: Department of Department of Neurosurgery, Seoul National University Hospital, 110-744 Seoul, Republic of Korea.
authors: Chul-Kee
authors: CK
authors: Park
authors: Department of Internal Medicine, Cancer Research Institute, Seoul National University Hospital, 110-744 Seoul, Republic of Korea.
authors: Tae Min
authors: TM
authors: Kim
authors: Department of Pathology, Seoul National University Hospital, 110-744 Seoul, Republic of Korea.
authors: Sung-Hye
authors: SH
authors: Park
authors: Department of Radiation Oncology, Cancer Research Institute, Seoul National University Hospital, 110-744 Seoul, Republic of Korea.
authors: Il Han
authors: IH
authors: Kim
authors: Department of Radiology, Seoul National University Hospital, 110-744 Seoul, Republic of Korea; Center for Nanoparticle Research, Institute for Basic Science (IBS), and School of Chemical and Biological Engineering, Seoul National University, 151-742 Seoul, Republic of Korea. Electronic address: verocay@snuh.org.
authors: Seung Hong
authors: SH
authors: Choi
mesh_terms: D000328:Adult; D001921:Brain / Q000000981:diagnostic imaging / Q000473:pathology; D001932:Brain Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology; D003287:Contrast Media; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods*; D005260:Female; D018303:Ganglioglioma / Q000000981:diagnostic imaging* / Q000473:pathology; D006801:Humans; D018810:Magnetic Resonance Angiography / Q000379:methods*; D008297:Male; D008875:Middle Aged; D009837:Oligodendroglioma / Q000000981:diagnostic imaging* / Q000473:pathology; D012372:ROC Curve
chemical_list: D003287:Contrast Media
keywords: Apparent diffusion coefficient; Cerebral blood volume; Ganglioglioma; Oligodendroglioma