title: Association between exercise-induced change in body composition and change in cardiometabolic risk factors in postmenopausal South Asian women.
abstract: The South Asian population suffers from a high prevalence of type 2 diabetes and cardiovascular disease (CVD). A unique obesity phenotype of elevated visceral adipose tissue (VAT) is associated with CVD risk among South Asians. Exercise-induced reduction in VAT and body fat is an effective mechanism to improve cardiometabolic risk factors but this has not been shown in South Asians. Whether exercise-induced changes in measurements such as waist circumference (WC) are independently related to changes in cardiometabolic risk factors in South Asians is unknown. Multi-slice computed tomography scanning was used to assess VAT, cardiometabolic risk factors through a fasting blood sample, and body fat using dual-energy X-ray absorptiometry. Forty- nine postmenopausal South Asian women who participated in two 12-week aerobic exercise programs were included. Bivariate correlations were used to assess associations between change in cardiometabolic risk factors and change in body composition. Regression analyses were conducted with change in glucose, insulin, and homeostatic model assessment of insulin resistance (HOMA-IR) as dependent variables and change in body composition as independent variables of interest. There were significant associations between changes in fasting insulin, glucose, and HOMA-IR with change in VAT. The association between change in VAT and these cardiometabolic risk factors was independent of change in other body composition variables of interest. South Asian women should be encouraged to engage in aerobic activity to reduce their risk of type 2 diabetes and CVD, and physicians should be aware of improvements in glucose regulation with exercise training not observed through reductions in WC.
authors: a Department of Biomedical Physiology and Kinesiology, Simon Fraser University, Vancouver, BC V6B 5K3, Canada.
authors: Iris A
authors: IA
authors: Lesser
authors: b Department of Physical Therapy and Centre for Heart Lung Innovation, University of British Columbia and St Paul's Hospital, Vancouver, BC V6Z 1Y6, Canada.
authors: Jordan A
authors: JA
authors: Guenette
authors: c Faculty of Health, Kwantlen Polytechnic University, Surrey, BC V3W 2M8, Canada.
authors: Amandah
authors: A
authors: Hoogbruin
authors: a Department of Biomedical Physiology and Kinesiology, Simon Fraser University, Vancouver, BC V6B 5K3, Canada.|d Centre for Hip Health and Mobility, University of British Columbia, Vancouver, BC V5Z 1M9, Canada.
authors: Dawn C
authors: DC
authors: Mackey
authors: e School of Population and Public Health, University of British Columbia and St. Paul's Hospital, Vancouver, BC V6Z 1Y6, Canada.
authors: Joel
authors: J
authors: Singer
authors: f Centre for Population Health Sciences, University of Edinburgh, Edinburgh EH8 9AD, UK.
authors: Danijela
authors: D
authors: Gasevic
authors: a Department of Biomedical Physiology and Kinesiology, Simon Fraser University, Vancouver, BC V6B 5K3, Canada.|g Faculty of Health Sciences, Simon Fraser University, Burnaby, BC V5A 1S6, Canada.|h Division of Cardiology, Providence Health Care, Vancouver, BC V6Z 1Y6, Canada.
authors: Scott A
authors: SA
authors: Lear
mesh_terms: D015502:Absorptiometry, Photon; D050154:Adiposity / Q000208:ethnology; D001208:Asia / Q000208:ethnology; D015415:Biomarkers / Q000097:blood; D015992:Body Mass Index; D001955:British Columbia / Q000453:epidemiology; D002318:Cardiovascular Diseases / Q000453:epidemiology / Q000208:ethnology / Q000209:etiology / Q000517:prevention & control*; D003924:Diabetes Mellitus, Type 2 / Q000453:epidemiology / Q000208:ethnology / Q000209:etiology / Q000517:prevention & control*; D015444:Exercise; D005260:Female; D006801:Humans; D007333:Insulin Resistance / Q000208:ethnology; D050152:Intra-Abdominal Fat / Q000000981:diagnostic imaging; D008875:Middle Aged; D056128:Obesity, Abdominal / Q000000981:diagnostic imaging / Q000378:metabolism / Q000503:physiopathology / Q000628:therapy*; D017698:Postmenopause / Q000208:ethnology; D012307:Risk Factors; D050507:Subcutaneous Fat, Abdominal / Q000000981:diagnostic imaging; D014057:Tomography, X-Ray Computed; D055105:Waist Circumference / Q000208:ethnology
chemical_list: D015415:Biomarkers
keywords: Asie du Sud; South Asian; cardiometabolic risk factors; ethnicity; ethnicité; exercice physique; exercise; facteurs de risque cardiométabolique; gras viscéral; tour de taille; visceral fat; waist circumference