title: Progressive outer retinal necrosis-like retinitis in immunocompetent hosts.
abstract: We describe two young immunocompetent women presenting with bilateral retinitis with outer retinal necrosis involving posterior pole with centrifugal spread and multifocal lesions simulating progressive outer retinal necrosis (PORN) like retinitis. Serology was negative for HIV and CD4 counts were normal; however, both women were on oral steroids at presentation for suspected autoimmune chorioretinitis. The retinitis in both eyes responded well to oral valaciclovir therapy. However, the eye with the more fulminant involvement developed retinal detachment with a loss of vision. Retinal atrophy was seen in the less involved eye with preservation of vision. Through these cases, we aim to describe a unique evolution of PORN-like retinitis in immunocompetent women, which was probably aggravated by a short-term immunosuppression secondary to oral steroids.
authors: Department of Ophthalmology, All India Institute of Medical Sciences, New Delhi, Delhi, India.
authors: Rohan
authors: R
authors: Chawla
authors: Department of Ophthalmology, All India Institute of Medical Sciences, New Delhi, Delhi, India.
authors: Koushik
authors: http://orcid.org/0000-0002-9756-128X
authors: K
authors: Tripathy
authors: Department of Ophthalmology, All India Institute of Medical Sciences, New Delhi, Delhi, India.
authors: Varun
authors: V
authors: Gogia
authors: Department of Ophthalmology, All India Institute of Medical Sciences, New Delhi, Delhi, India.
authors: Pradeep
authors: P
authors: Venkatesh
mesh_terms: D000212:Acyclovir / Q000031:analogs & derivatives / Q000627:therapeutic use; D000293:Adolescent; D000998:Antiviral Agents / Q000627:therapeutic use; D002825:Chorioretinitis / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000821:virology; D005260:Female; D006801:Humans; D007121:Immunocompetence; D015882:Retinal Necrosis Syndrome, Acute / Q000000981:diagnostic imaging / Q000209:etiology*; D013256:Steroids / Q000009:adverse effects*; D041623:Tomography, Optical Coherence; D000077483:Valacyclovir; D014633:Valine / Q000031:analogs & derivatives / Q000627:therapeutic use; D014777:Virus Diseases / Q000150:complications* / Q000188:drug therapy; D014786:Vision Disorders / Q000209:etiology; D055815:Young Adult
chemical_list: D000998:Antiviral Agents; D013256:Steroids; D014633:Valine; D000077483:Valacyclovir; D000212:Acyclovir