title: [Recommendations for the preparation and administration of antituberculosis drugs in children. Second phase of the Magistral Project of the Spanish Network for the Study of Paediatric Tuberculosis (pTBred)].
abstract: The Spanish Network for the Study of Paediatric Tuberculosis has shown a lack of national consensus on the treatment of tuberculosis in children, partly due to the unavailability of paediatric presentations of antituberculosis drugs. The harmonisation of tuberculosis treatment in children is a priority in Spain. A joint action is proposed by a group of Spanish experts in childhood tuberculosis and in the area of Paediatric Pharmacology. To this end, a pTBred-led workgroup of members from five scientific bodies has been created. Drug pharmaceutical compounding in oral suspensions or oral solutions are recommended as follows: isoniazid 50mg/mL, pyrazinamide 100mg/mL, and ethambutol 50mg/mL. Raw materials, period of validity, and storage conditions are specified. Recommendations for the use of fixed-dose combination drugs are also established. If oral solutions/suspensions or fixed-dose combination drugs are not appropriate, the use of crushed tablets is recommended. Adherence to treatment and optimal dosing of antituberculosis drugs are critical in the control and eradication of TB. This multidisciplinary document provides an opportunity to promote the appropriate treatment of paediatric tuberculosis in Spain, and should become a useful tool for paediatricians and pharmacists.
authors: Red Española de Estudio de la Tuberculosis Pediátrica (pTBred); Sociedad Española de Infectología Pediátrica (SEIP); Comité de Medicamentos de la Asociación Española de Pediatría (CM-AEP). Electronic address: roipineiro@telefonica.net.
authors: Roi
authors: R
authors: Piñeiro Pérez
authors: Red Española de Estudio de la Tuberculosis Pediátrica (pTBred); Sociedad Española de Infectología Pediátrica (SEIP).
authors: Begoña
authors: B
authors: Santiago García
authors: Sociedad Española de Farmacia Hospitalaria (SEFH).
authors: Belén
authors: B
authors: Rodríguez Marrodán
authors: Red Española de Estudio de la Tuberculosis Pediátrica (pTBred); Sociedad Española de Infectología Pediátrica (SEIP).
authors: Fernando
authors: F
authors: Baquero-Artigao
authors: Comité de Medicamentos de la Asociación Española de Pediatría (CM-AEP); Sociedad Española de Farmacia Hospitalaria (SEFH).
authors: Cecilia M
authors: CM
authors: Fernández-Llamazares
authors: Sociedad Española de Farmacia Hospitalaria (SEFH).
authors: María
authors: M
authors: Goretti López-Ramos
authors: Sociedad Española de Farmacia Hospitalaria (SEFH).
authors: Joan
authors: J
authors: Vinent Genestar
authors: Red Española de Estudio de la Tuberculosis Pediátrica (pTBred); Sociedad Española de Neumología Pediátrica (SENP).
authors: David
authors: D
authors: Gómez-Pastrana Durán
authors: Red Española de Estudio de la Tuberculosis Pediátrica (pTBred); Sociedad Española de Infectología Pediátrica (SEIP); Comité de Medicamentos de la Asociación Española de Pediatría (CM-AEP).
authors: María José
authors: MJ
authors: Mellado Peña
mesh_terms: D000995:Antitubercular Agents / Q000008:administration & dosage*; D002648:Child; D004338:Drug Combinations; D006801:Humans; D014376:Tuberculosis / Q000188:drug therapy*
chemical_list: D000995:Antitubercular Agents; D004338:Drug Combinations
keywords: Antituberculosis drugs; Children; Clinical practice guideline; Drug pharmaceutical compounding; Formulación magistral; Fármacos antituberculosos; Guía de práctica clínica; Niños; Tuberculosis