title: IDH1, Histone Methylation, and So Forth.
abstract: IDH mutants cause aberrant DNA and histone methylation and contribute to hematological and neuronal malignancies. In this issue of Cancer Cell, Inoue et al. describe a potential specific effect of IDH1 mutations that reduces Atm expression via inhibition of H3K9 demethylases, which may represent a first step toward cellular transformation.
authors: INSERM U1170, 94805 Villejuif, France; Equipe Labellisée Ligue Nationale Contre le Cancer, Paris, France; Université Paris Sud, Université Paris-Saclay, 94720 Le Kremlin-Bicêtre, France; Gustave Roussy, Université Paris-Saclay, 94805 Villejuif, France. Electronic address: virginie.penard-lacronique@inserm.fr.
authors: Virginie
authors: V
authors: Penard-Lacronique
authors: INSERM U1170, 94805 Villejuif, France; Equipe Labellisée Ligue Nationale Contre le Cancer, Paris, France; Université Paris Sud, Université Paris-Saclay, 94720 Le Kremlin-Bicêtre, France; Gustave Roussy, Université Paris-Saclay, 94805 Villejuif, France. Electronic address: olivier.bernard@inserm.fr.
authors: Olivier A
authors: OA
authors: Bernard
mesh_terms: D019175:DNA Methylation; D006657:Histones / Q000235:genetics*; D006801:Humans; D007521:Isocitrate Dehydrogenase / Q000235:genetics*; D008745:Methylation; D009154:Mutation; D009369:Neoplasms / Q000235:genetics
chemical_list: D006657:Histones; D007521:Isocitrate Dehydrogenase