title: Myxoid liposarcoma with pleomorphic cells: Report of two cases with molecular confirmation of FUS gene rearrangements.
abstract: Myxoid liposarcoma is usually composed of uniform oval to short spindle cells in a prominent myxoid stroma. We report here two cases of myxoid liposarcoma containing unusual pleomorphic cells harboring FUS gene rearrangements. One of the lesions arose in the right loin of a 70-year-old man, while the other in the right upper arm of a 73-year-old woman. Both tumors were composed of a lobular proliferation of short spindle to oval cells, admixed with lipoblastic cells and scattered pleomorphic cells including pseudolipoblast-like or Touton-type giant cell-like cells, embedded in an abundant myxoid stroma containing a network of delicate capillary vessels. An FUS gene rearrangement was detected by fluorescence in situ hybridization in one case, and an FUS-DDIT3 fusion gene transcript by reverse transcription-polymerase chain reaction in the other. These unique cases focus our attention to a much wider histological variation of myxoid liposarcoma than expected, as well as to the value of molecular testing for final diagnosis of such myxoid sarcomas.
authors: Department of Pathology & Oncology, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan. Electronic address: uchihashi@med.uoeh-u.ac.jp.
authors: Kazuyoshi
authors: K
authors: Uchihashi
authors: Department of Pathology & Oncology, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan.
authors: Atsuji
authors: A
authors: Matsuyama
authors: Department of Pathology, St. Mary's Hospital, Kurume, Japan.
authors: Masamichi
authors: M
authors: Nakayama
authors: Department of Orthopedic Surgery, Kokura Medical Center, Kitakyushu, Japan.
authors: Akio
authors: A
authors: Sakamoto
authors: Department of Pathology & Oncology, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan.
authors: Eisuke
authors: E
authors: Shiba
authors: Department of Pathology & Oncology, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan.
authors: Masanori
authors: M
authors: Hisaoka
mesh_terms: D000368:Aged; D005260:Female; D015321:Gene Rearrangement; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D018208:Liposarcoma, Myxoid / Q000235:genetics* / Q000473:pathology*; D008297:Male; D015514:Oncogene Proteins, Fusion / Q000235:genetics*; D034702:RNA-Binding Protein FUS / Q000235:genetics*; D020133:Reverse Transcriptase Polymerase Chain Reaction
chemical_list: C000599550:FUS protein, human; C532377:FUS-DDIT3 fusion protein, human; D015514:Oncogene Proteins, Fusion; D034702:RNA-Binding Protein FUS
keywords: FUS-DDIT3; Fusion gene; Histopathology; Myxoid liposarcoma; Pleomorphic