title: Adiabatically prepared spin-lock approach for T1ρ-based dynamic glucose enhanced MRI at ultrahigh fields.
abstract: Chemical exchange sensitive spin-lock and related techniques allow to observe the uptake of administered D-glucose in vivo. The exchange-weighting increases with the magnetic field strength, but inhomogeneities in the radiofrequency (RF) field at ultrahigh field whole-body scanners lead to artifacts in conventional spin-lock experiments. Thus, our aim was the development of an adiabatically prepared T1ρ-based imaging sequence applicable to studies of glucose metabolism in tumor patients at ultrahigh field strengths.
  
  
  
  An adiabatically prepared on-resonant spin-lock approach was realized at a 7 Tesla whole-body scanner and compared with conventional spin-lock. The insensitivity to RF field inhomogeneities as well as the chemical exchange sensitivity of the approach was investigated in simulations, model solutions and in the human brain.
  
  
  
  The suggested spin-lock approach was shown to be feasible for in vivo application at ultrahigh field whole-body scanners and showed substantially improved image quality compared with conventional spin-lock. The sensitivity of the presented method to glucose was verified in model solutions and a glucose contrast was observed in a glioblastoma patient after intravenous administration of glucose solution.
  
  
  
  An adiabatically prepared spin-lock preparation was presented that enables a homogeneous and chemical exchange sensitive T1ρ-based imaging at ultra-high field whole-body scanners, e.g., for T1ρ-based dynamic glucose enhanced MRI. Magn Reson Med 78:215-225, 2017. © 2016 International Society for Magnetic Resonance in Medicine.
authors: German Cancer Research Center (DKFZ), Division of Medical Physics in Radiology, Heidelberg, Germany.
authors: Patrick
authors: P
authors: Schuenke
authors: German Cancer Research Center (DKFZ), Division of Radiology, Heidelberg, Germany.
authors: Christina
authors: C
authors: Koehler
authors: German Cancer Research Center (DKFZ), Division of Medical Physics in Radiology, Heidelberg, Germany.
authors: Andreas
authors: A
authors: Korzowski
authors: German Cancer Research Center (DKFZ), Division of Medical Physics in Radiology, Heidelberg, Germany.
authors: Johannes
authors: J
authors: Windschuh
authors: German Cancer Research Center (DKFZ), Division of Medical Physics in Radiology, Heidelberg, Germany.
authors: Peter
authors: P
authors: Bachert
authors: German Cancer Research Center (DKFZ), Division of Medical Physics in Radiology, Heidelberg, Germany.
authors: Mark E
authors: ME
authors: Ladd
authors: Department of Neurology, University Hospital Heidelberg, Heidelberg, Germany.
authors: Sibu
authors: S
authors: Mundiyanapurath
authors: German Cancer Research Center (DKFZ), Division of Radiology, Heidelberg, Germany.
authors: Daniel
authors: D
authors: Paech
authors: German Cancer Research Center (DKFZ), Division of Radiology, Heidelberg, Germany.
authors: Sebastian
authors: S
authors: Bickelhaupt
authors: German Cancer Research Center (DKFZ), Division of Radiology, Heidelberg, Germany.
authors: David
authors: D
authors: Bonekamp
authors: German Cancer Research Center (DKFZ), Division of Radiology, Heidelberg, Germany.
authors: Heinz-Peter
authors: HP
authors: Schlemmer
authors: German Cancer Research Center (DKFZ), Division of Radiology, Heidelberg, Germany.
authors: Alexander
authors: A
authors: Radbruch
authors: German Cancer Research Center (DKFZ), Division of Medical Physics in Radiology, Heidelberg, Germany.|Max-Planck-Institute for Biological Cybernetics, Tübingen, Baden-Württemberg, Germany.
authors: Moritz
authors: M
authors: Zaiss
mesh_terms: D000465:Algorithms; D001921:Brain / Q000000981:diagnostic imaging* / Q000378:metabolism*; D005947:Glucose / Q000378:metabolism*; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D060526:Magnetic Fields; D008279:Magnetic Resonance Imaging / Q000295:instrumentation / Q000379:methods*; D057054:Molecular Imaging / Q000379:methods*; D019047:Phantoms, Imaging; D011829:Radiation Dosage; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013113:Spin Labels
chemical_list: D013113:Spin Labels; D005947:Glucose
keywords: CESL; CEST; DGE; T1rho; T1ρ; glucoCESL; glucoCEST; spin-lock