title: 3 Tesla-Diffusion Tensor Imaging in Autosomal Dominant Polycystic Kidney Disease: The Nephrologist's Point of View.
abstract: OBJECTIVE
  CT, MRI and ultrasound are currently used for screening and follow-up of individuals affected by autosomal dominant polycystic kidney disease (ADPKD). Dynamic contrast-enhanced MRI studies renal perfusion after gadolinium administration, with possible side effects, such as nephrogenic systemic fibrosis. The aim of our study was to evaluate the clinical application of 3 Tesla (3T)-diffusion tensor image (DTI) in ADPKD patients, correlating its parameters, such as fractional anisotropy (FA), and apparent diffusion coefficient (ADC) with kidney function tests.
  
  
  METHODS
  Eight ADPKD patients and 6 healthy volunteers (HS) were enrolled. FA and ADC mean values were calculated. And correlations between DTI-parameters, creatinine and estimated glomerular filtration rate (eGFR) were evaluated.
  
  
  RESULTS
  Parenchymal FA was significantly lower in ADPKD than HS (FA: 0.17 ± 0.03 vs. 0.22 ± 0.01; p = 0.02), whereas parenchymal ADC was higher in patients than controls (2.48 (×10-3) ± 0.16 vs. 2.28 (×10-3) ± 0.09), but a statistically significant difference was not achieved (p = 0.27). Direct correlations were revealed between eGFR and FA (r = 0.82; p = 0.0003), whereas an inverse correlation was found with creatinine (r = -0.77; p = 0.001). Similarly, ADC closely correlated with creatinine (r = 0.79; p = 0.0006) and eGFR (r = -0.620; p = 0.01).
  
  
  CONCLUSIONS
  3T-DTI is a promising radiological tool that could be used by nephrologists to evaluate ADPKD patients, highlighting early micro-structure alterations, without side effects and contrast agent administration.
authors: Department of Clinical and Experimental Medicine, Nephrology and Dialysis Unit, University of Messina, Messina, Italy.
authors: Rosaria
authors: R
authors: Lupica
authors: Enricomaria
authors: E
authors: Mormina
authors: Antonio
authors: A
authors: Lacquaniti
authors: Domenico
authors: D
authors: Trimboli
authors: Biagio
authors: B
authors: Bianchimano
authors: Silvia
authors: S
authors: Marino
authors: Placido
authors: P
authors: Bramanti
authors: Marcello
authors: M
authors: Longo
authors: Michele
authors: M
authors: Buemi
authors: Francesca
authors: F
authors: Granata
mesh_terms: D000328:Adult; D056324:Diffusion Tensor Imaging / Q000379:methods*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D016891:Polycystic Kidney, Autosomal Dominant / Q000000981:diagnostic imaging*; D011446:Prospective Studies