title: Synthesis, antibacterial and antiproliferative potential of some new 1-pyridinecarbonyl-4-substituted thiosemicarbazide derivatives.
abstract: In this study, the antibacterial, cytotoxic and antiproliferative activities of novel thiosemicarbazide derivatives were assessed. Our results demonstrated that some of the novel compounds possess good antibacterial properties againstStaphylococcus epidermidis,Streptococcus mutansandStreptococcussanguinisand are only slightly cytotoxic; thus, they exhibit an excellent therapeutic index, which is higher than that of ethacridine lactate. Moreover, our data showed that compounds2and4have an antiproliferative activity against human breast adenocarcinoma and human hepatocellular carcinoma cell lines. We expect that the novel thiosemicarbazide derivatives can be used as agents for treatment of dental caries and also for chemotherapy support.
authors: Department of Organic Chemistry, Medical University, Chodzki 4A, 20-093 Lublin, Poland.
authors: Monika
authors: M
authors: Pitucha
authors: Department of Organic Chemistry, Medical University, Chodzki 4A, 20-093 Lublin, Poland.
authors: Maciej
authors: M
authors: Woś
authors: Chair and Department of Biochemistry and Biotechnology, Medical University, Chodzki 1, 20-093 Lublin, Poland.
authors: Malgorzata
authors: M
authors: Miazga-Karska
authors: Chair and Department of Biochemistry and Biotechnology, Medical University, Chodzki 1, 20-093 Lublin, Poland.
authors: Katarzyna
authors: K
authors: Klimek
authors: Department of Crystallography, Faculty of Chemistry, Maria Curie-Sklodowska University, pl. M. Curie-Skłodowskiej 3, 20-031 Lublin, Poland.
authors: Barbara
authors: B
authors: Mirosław
authors: Department of Organic Chemistry, Medical University, Chodzki 4A, 20-093 Lublin, Poland.
authors: Anna
authors: A
authors: Pachuta-Stec
authors: Department of Medicinal Chemistry, Medical University of Lublin, Jaczewskiego 4, 20-090 Lublin, Poland.
authors: Agata
authors: A
authors: Gładysz
authors: Chair and Department of Biochemistry and Biotechnology, Medical University, Chodzki 1, 20-093 Lublin, Poland.
authors: Grazyna
authors: G
authors: Ginalska
keywords: Antibacterial activity; Cell proliferation; Cytotoxicity; Thiosemicarbazide