title: Reference intervals for biochemical and haematological analytes of juvenile captive-bred long-tailed macaques (Macaca fascicularis) from Mauritius with examination of the effects of individual characteristics using principal component analysis.
abstract: The Mauritian cynomolgus macaque (Macaca fascicularis) is widely used in biomedical research. Determining reference intervals for biochemical and haematological analytes provides an important tool for clinical diagnosis and pre-clinical research.
  
  
  
  Blood samples from 736 Mauritian long-tailed macaques were analysed to determine reference intervals of 13 biochemical and 10 haematological analytes. The need for partitioning the reference interval between males and females was determined. To examine the variation associated with age, body weight and sex on the analytes, our correlating, multivariate data set was first reduced using principal component analysis, and then the effect of these characteristics on factor scores was examined using GLM analysis.
  
  
  
  Partitioning of reference intervals, based on sex, was recommended for albumin, alkaline phosphatase and mean corpuscular haemoglobin. Sex significantly influenced the concentration of lymphocytes, granulocytes and white blood cells.
  
  
  
  These findings provide useful reference data for research involving Mauritian long-tailed macaques.
authors: Bioculture (Mauritius) Ltd, Senneville, Mauritius.
authors: Sandiren
authors: S
authors: Naiken
authors: Bioculture (Mauritius) Ltd, Senneville, Mauritius.
authors: Mary-Ann
authors: MA
authors: Griffiths
authors: Bioculture (Mauritius) Ltd, Senneville, Mauritius.
authors: Jaymahalaxmi R
authors: JR
authors: Hurdial
authors: Bioculture (Mauritius) Ltd, Senneville, Mauritius.
authors: Sam
authors: S
authors: Narainapoulle
authors: Bioculture (Mauritius) Ltd, Senneville, Mauritius.
authors: Paul
authors: P
authors: Honess
mesh_terms: D000367:Age Factors; D000818:Animals; D001774:Blood Chemical Analysis / Q000592:standards / Q000662:veterinary*; D001835:Body Weight; D005260:Female; D006403:Hematologic Tests / Q000592:standards / Q000662:veterinary*; D008252:Macaca fascicularis / Q000097:blood*; D008297:Male; D008436:Mauritius; D025341:Principal Component Analysis; D012016:Reference Values; D012737:Sex Factors
keywords: blood biochemistry; cynomolgus macaque; haematology; principal component analysis; reference intervals