title: Projected increase in amyotrophic lateral sclerosis from 2015 to 2040.
abstract: Although amyotrophic lateral sclerosis (ALS) is relatively rare, the socioeconomic significance of the disease is extensive. It is therefore vital to project the epidemiologic trend of ALS. To date, there have been few published studies attempting to estimate the number and distribution of ALS cases in the upcoming years. Here we show that the number of ALS cases across the globe will increase from 222,801 in 2015 to 376,674 in 2040, representing an increase of 69%. This increase is predominantly due to ageing of the population, particularly among developing nations. This projection is likely an underestimate due to improving healthcare and economic conditions. The results should be used to inform healthcare policy to more efficiently allocate healthcare resources.
authors: Neuromuscular Diseases Research Section, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, Maryland 20892, USA.|The Commonwealth Medical College, Scranton, Pennsylvania 18509, USA.
authors: Karissa C
authors: KC
authors: Arthur
authors: 'Rita Levi Montalcini' Department of Neuroscience, University of Torino, Turin 10124, Italy.|Neuroscience Institute of Torino, Turin 10124, Italy.
authors: Andrea
authors: A
authors: Calvo
authors: Statistical Genetics Group, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, Maryland 20892, USA.
authors: T Ryan
authors: TR
authors: Price
authors: Neurodegenerative Diseases Research Unit, Laboratory of Neurogenetics, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA.
authors: Joshua T
authors: JT
authors: Geiger
authors: 'Rita Levi Montalcini' Department of Neuroscience, University of Torino, Turin 10124, Italy.|Neuroscience Institute of Torino, Turin 10124, Italy.
authors: Adriano
authors: A
authors: Chiò
authors: Neuromuscular Diseases Research Section, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, Maryland 20892, USA.|Brain Science Institute, Department of Neurology, Johns Hopkins University, Baltimore, Maryland 21205, USA.
authors: Bryan J
authors: BJ
authors: Traynor
mesh_terms: D017677:Age Distribution; D000368:Aged; D000375:Aging; D000690:Amyotrophic Lateral Sclerosis / Q000175:diagnosis / Q000453:epidemiology*; D005260:Female; D014943:Global Health; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D015995:Prevalence