title: Symptomatic Primary Selective Immunoglobulin M Deficiency with Nonprotective Pneumococcal Titers Responsive to Subcutaneous Immunoglobulin Treatment.
abstract: Selective immunoglobulin M deficiency (SIgMD) is a rare disorder with varying clinical features. The prevalence of SIgMD is 0.03-3%. Patients may be asymptomatic or else present with recurrent infection, autoimmunity, atopic disease and/or malignancy. About 50% of patients with symptomatic SIgMD also have impaired antibody responses to the pneumococcal polysaccharide vaccine. We report on an adult who presented with symptomatic SIgMD with impaired pneumococcal polysaccharide antibody responses and lymphopenia, who experienced a significant clinical improvement in the frequency of infections after subcutaneous immunoglobulin replacement therapy.
authors: Division of Allergy and Immunology, Department of Internal Medicine, University of South Florida, Morsani College of Medicine, James A. Haley Veterans' Affairs Hospital, Tampa, Fla., USA.
authors: Shiven S
authors: SS
authors: Patel
authors: Jennifer E
authors: JE
authors: Fergeson
authors: Mark C
authors: MC
authors: Glaum
authors: Richard F
authors: RF
authors: Lockey
mesh_terms: D000328:Adult; D000361:Agammaglobulinemia / Q000097:blood* / Q000150:complications*; D000906:Antibodies / Q000008:administration & dosage*; D006801:Humans; D007116:Immunization, Passive / Q000379:methods*; D007075:Immunoglobulin M / Q000097:blood*; D007136:Immunoglobulins / Q000097:blood; D007279:Injections, Subcutaneous; D008297:Male; D011008:Pneumococcal Infections / Q000209:etiology* / Q000628:therapy*; D016896:Treatment Outcome
chemical_list: D000906:Antibodies; D007075:Immunoglobulin M; D007136:Immunoglobulins