title: PHACTR1 Gene Polymorphism Is Associated with Increased Risk of Developing Premature Coronary Artery Disease in Mexican Population.
abstract: Single-nucleotide polymorphisms (SNPs) in the protein phosphatase and actin regulator 1 gene (PHACTR1) have been associated with susceptibility to develop several diseases, including cardiovascular disease. The purpose of this study was to evaluate the role of two polymorphisms (rs2026458 and rs9349379) of the PHACTR1 gene in the susceptibility to the risk of developing premature coronary artery disease (CAD) in the Mexican population. The genotype analysis was performed using 5'exonuclease TaqMan genotyping assays in a group of 994 patients with premature CAD and 703 controls. A similar genotype distribution of rs2026458 was observed in both groups; however, under an additive model adjusted by age, body mass index, type 2 diabetes mellitus, smoking, dyslipidemia, and hypertension, the rs9349379 G allele was associated with a higher risk for developing premature CAD (odds ratio (OR) = 1.22, 95% confidence interval (CI) = 1.03-1.46, p-value (p) = 0.024). The two PHACTR1 polymorphisms were not in linkage disequilibrium. In summary, our results suggest that the PHACTR1 rs9349379 polymorphism plays an important role in the risk of developing premature CAD in the Mexican population.
authors: Department of Molecular Biology, National Institute of Cardiology "Ignacio Chávez", Juan Badiano No. 1, Col. Sección XVI, Tlalpan 14080, Mexico City, Mexico. unicanona@yahoo.com.mx.
authors: Nonanzit
authors: N
authors: Pérez-Hernández
authors: Department of Molecular Biology, National Institute of Cardiology "Ignacio Chávez", Juan Badiano No. 1, Col. Sección XVI, Tlalpan 14080, Mexico City, Mexico. gvargas63@yahoo.com.
authors: Gilberto
authors: G
authors: Vargas-Alarcón
authors: Department of Endocrinology, National Institute of Cardiology "Ignacio Chávez", Mexico City 14080, Mexico. rossy_posadas_s@yahoo.it.
authors: Rosalinda
authors: R
authors: Posadas-Sánchez
authors: Community Health Research Department, Children's Hospital of Mexico "Federico Gomez", Ministry of Health (SSA), Mexico City 06720, Mexico. amr70@hotmail.com.
authors: Nancy
authors: N
authors: Martínez-Rodríguez
authors: Juarez Autonomous University of Tabasco, Multidisciplinary Academic Division of Comacalco, Villahermosa 86040, Mexico. alfonso_tovillasz@yahoo.com.mx.
authors: Carlos Alfonso
authors: CA
authors: Tovilla-Zárate
authors: Department of Molecular Biology, National Institute of Cardiology "Ignacio Chávez", Juan Badiano No. 1, Col. Sección XVI, Tlalpan 14080, Mexico City, Mexico. asaelrodriguezcortes@hotmail.com.
authors: Adrián Asael
authors: AA
authors: Rodríguez-Cortés
authors: Department of Molecular Biology, National Institute of Cardiology "Ignacio Chávez", Juan Badiano No. 1, Col. Sección XVI, Tlalpan 14080, Mexico City, Mexico. opmendez@yahoo.com.
authors: Oscar
authors: O
authors: Pérez-Méndez
authors: Department of Molecular Biology, National Institute of Cardiology "Ignacio Chávez", Juan Badiano No. 1, Col. Sección XVI, Tlalpan 14080, Mexico City, Mexico. rubenblach@gmail.com.
authors: Ruben
authors: R
authors: Blachman-Braun
authors: Department of Molecular Biology, National Institute of Cardiology "Ignacio Chávez", Juan Badiano No. 1, Col. Sección XVI, Tlalpan 14080, Mexico City, Mexico. josemanuel_rodriguezperez@yahoo.com.mx.
authors: José Manuel
authors: JM
authors: Rodríguez-Pérez
mesh_terms: D000328:Adult; D000483:Alleles; D003324:Coronary Artery Disease / Q000453:epidemiology / Q000235:genetics*; D050171:Dyslipidemias / Q000235:genetics; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D006801:Humans; D006973:Hypertension / Q000235:genetics; D008297:Male; D008800:Mexico; D008840:Microfilament Proteins / Q000235:genetics*; D008875:Middle Aged; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*
chemical_list: D008840:Microfilament Proteins; C570134:PHACTR1 protein, human
keywords: PHACTR1 gene; coronary artery disease; genetic polymorphisms; vascular calcification