title: Inhibition of NLRP3 inflammasome as a therapeutic intervention in crystal-induced nephropathy.
abstract: Inflammasomes are important components of innate immunity system. Dysregulation of inflammasomes activation is central to the pathogenesis of inflammatory diseases. The measurement of inflammasomes activity especially in in vivo settings should give us important information to regulate inflammatory events. Ludwig-Portugall et al. clearly visualized the intrarenal activation of inflammasome in a murine model of crystal nephropathy using a proteolytic luciferase-based reporter, and showed that the blockade of NLRP3 inflammasome may prevent renal injuries.
authors: Division of Blood Purification, Kanazawa University Hospital, Kanazawa, Japan.
authors: Norihiko
authors: N
authors: Sakai
authors: Division of Blood Purification, Kanazawa University Hospital, Kanazawa, Japan.
authors: Kengo
authors: K
authors: Furuichi
authors: Department of Nephrology and Laboratory Medicine, Institute of Medical, Pharmaceutical, and Health Sciences, Faculty of Medicine, Kanazawa University, Kanazawa, Japan. Electronic address: twada@m-kanazawa.jp.
authors: Takashi
authors: T
authors: Wada
mesh_terms: D000818:Animals; D006801:Humans; D007113:Immunity, Innate; D058847:Inflammasomes / Q000276:immunology*; D053583:Interleukin-1beta / Q000276:immunology*; D007668:Kidney; D007674:Kidney Diseases; D051379:Mice
chemical_list: D058847:Inflammasomes; D053583:Interleukin-1beta