title: Prognostic Value of NME1 (NM23-H1) in Patients with Digestive System Neoplasms: A Systematic Review and Meta-Analysis.
abstract: OBJECTIVE
  There is a heated debate on whether the prognostic value of NME1 is favorable or unfavorable. Thus, we carried out a meta-analysis to evaluate the relationship between NME1 expression and the prognosis of patients with digestive system neoplasms.
  
  
  METHODS
  We searched PubMed, EMBASE and Web of Science for relevant articles. The pooled odd ratios (ORs) and corresponding 95%CI were calculated to evaluate the prognostic value of NME1 expression in patients with digestive system neoplasms, and the association between NME1 expression and clinicopathological factors. We also performed subgroup analyses to find out the source of heterogeneity.
  
  
  RESULTS
  2904 patients were pooled from 28 available studies in total. Neither the incorporative OR combined by 17 studies with overall survival (OR = 0.65, 95%CI:0.41-1.03, P = 0.07) nor the pooled OR with disease-free survival (OR = 0.75, 95%CI:0.17-3.36, P = 0.71) in statistics showed any significance. Although we couldn't find any significance in TNM stage (OR = 0.78, 95%CI:0.44-1.36, P = 0.38), elevated NME1 expression was related to well tumor differentiation (OR = 0.59, 95%CI:0.47-0.73, P<0.00001), negative N status (OR = 0.54, 95%CI:0.36-0.82, P = 0.003) and Dukes' stage (OR = 0.43, 95%CI:0.24-0.77, P = 0.004). And in the subgroup analyses, we only find the "years" which might be the source of heterogeneity of overall survival in gastric cancer.
  
  
  CONCLUSIONS
  The results showed that statistically significant association was found between NME1 expression and the tumor differentiation, N status and Dukes' stage of patients with digestive system cancers, while no significance was found in overall survival, disease-free survival and TNM stage. More and further researches should be conducted to reveal the prognostic value of NME1.
authors: Department of General Surgery, Kunshan First People's Hospital Affiliated to Jiangsu University, Kunshan Jiangsu, 215300, P. R. China.
authors: Wei
authors: W
authors: Han
authors: Department of General Surgery, Kunshan First People's Hospital Affiliated to Jiangsu University, Kunshan Jiangsu, 215300, P. R. China.|Department of General Surgery, Xishan People's Hospital, Wuxi Jiangsu, 215300, P. R. China.
authors: Chun-Tao
authors: CT
authors: Shi
authors: School of Medicine, Jiangsu University, Zhenjiang Jiangsu, 212001, P. R. China.
authors: Fei-Yun
authors: FY
authors: Cao
authors: Department of General Surgery, Kunshan First People's Hospital Affiliated to Jiangsu University, Kunshan Jiangsu, 215300, P. R. China.
authors: Fang
authors: F
authors: Cao
authors: Department of Radiotherapy and Oncology, Kunshan First People's Hospital Affiliated to Jiangsu University, Kunshan Jiangsu, 215300, P. R. China.
authors: Min-Bin
authors: MB
authors: Chen
authors: School of Medicine, Jiangsu University, Zhenjiang Jiangsu, 212001, P. R. China.
authors: Rong-Zhu
authors: RZ
authors: Lu
authors: Department of General Surgery, Kunshan First People's Hospital Affiliated to Jiangsu University, Kunshan Jiangsu, 215300, P. R. China.
authors: Hua-Bing
authors: HB
authors: Wang
authors: Department of General Surgery, Kunshan First People's Hospital Affiliated to Jiangsu University, Kunshan Jiangsu, 215300, P. R. China.
authors: Min
authors: M
authors: Yu
authors: Laboratory Department, Kunshan First People's Hospital Affiliated to Jiangsu University, Kunshan Jiangsu, 215300, P. R. China.
authors: Da-Wei
authors: DW
authors: He
authors: Digestive System Department, Kunshan First People's Hospital Affiliated to Jiangsu University, Kunshan Jiangsu, 215300, P. R. China.
authors: Qing-Hua
authors: QH
authors: Wang
authors: Department of General Surgery, Qiandeng Hospital, Kunshan Jiangsu, 215300, P. R. China.
authors: Jie-Feng
authors: JF
authors: Wang
authors: Laboratory Department, Kunshan First People's Hospital Affiliated to Jiangsu University, Kunshan Jiangsu, 215300, P. R. China.
authors: Xuan-Xuan
authors: XX
authors: Xu
authors: Department of General Surgery, Kunshan First People's Hospital Affiliated to Jiangsu University, Kunshan Jiangsu, 215300, P. R. China.
authors: Hou-Zhong
authors: HZ
authors: Ding
mesh_terms: D014408:Biomarkers, Tumor / Q000235:genetics / Q000378:metabolism*; D004067:Digestive System Neoplasms / Q000235:genetics / Q000378:metabolism / Q000473:pathology*; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D054778:NM23 Nucleoside Diphosphate Kinases / Q000378:metabolism*; D011379:Prognosis
chemical_list: D014408:Biomarkers, Tumor; D054778:NM23 Nucleoside Diphosphate Kinases; C517938:NME1 protein, human