title: Emergence of ileS2-Carrying, Multidrug-Resistant Plasmids in Staphylococcus lugdunensis.
abstract: Of 137 Staphylococcus lugdunensis isolates collected from two nephrology centers in Hong Kong, 10 (7.3%) and 3 (2.2%) isolates had high-level and low-level mupirocin resistance, respectively. Isolates with high-level resistance contained the plasmid-mediated ileS2 gene, while isolates with low-level resistance contained the mutation V588F within the chromosomal ileS gene. All but one of the ileS2-positive isolates belong to the predominating clone HKU1. Plasmids carrying the ileS2 gene were mosaic and also cocarry multiple other resistance determinants.
authors: Carol Yu Centre for Infection and Department of Microbiology, Queen Mary Hospital, University of Hong Kong, Hong Kong Special Administrative Region, People's Republic of China plho@hkucc.hku.hk.
authors: Pak-Leung
authors: 0000-0002-8811-1308
authors: PL
authors: Ho
authors: Carol Yu Centre for Infection and Department of Microbiology, Queen Mary Hospital, University of Hong Kong, Hong Kong Special Administrative Region, People's Republic of China.
authors: Melissa Chun-Jiao
authors: MC
authors: Liu
authors: Carol Yu Centre for Infection and Department of Microbiology, Queen Mary Hospital, University of Hong Kong, Hong Kong Special Administrative Region, People's Republic of China.
authors: Kin-Hung
authors: KH
authors: Chow
authors: Department of Clinical Pathology, Kwong Wah Hospital, Hong Kong Special Administrative Region, People's Republic of China.
authors: Cindy Wing-Sze
authors: CW
authors: Tse
authors: Carol Yu Centre for Infection and Department of Microbiology, Queen Mary Hospital, University of Hong Kong, Hong Kong Special Administrative Region, People's Republic of China.
authors: Wai-U
authors: WU
authors: Lo
authors: Department of Medicine and Geriatrics, Kwong Wah Hospital, Hong Kong Special Administrative Region, People's Republic of China.
authors: Siu-Ka
authors: SK
authors: Mak
authors: Department of Medicine, Tung Wah Hospital, Hong Kong Special Administrative Region, People's Republic of China.
authors: Wai-Kei
authors: WK
authors: Lo
mesh_terms: D024901:Drug Resistance, Multiple, Bacterial / Q000187:drug effects / Q000235:genetics*; D005798:Genes, Bacterial; D006723:Hong Kong; D006801:Humans; D016106:Methicillin Resistance / Q000235:genetics; D008826:Microbial Sensitivity Tests; D016712:Mupirocin / Q000494:pharmacology / Q000627:therapeutic use; D009154:Mutation; D010957:Plasmids; D057787:Staphylococcus lugdunensis / Q000187:drug effects* / Q000235:genetics* / Q000302:isolation & purification
chemical_list: D016712:Mupirocin