title: Screening the DNA interaction ability and antimicrobial activity of a few novel bioactive complexes tethering N-((2-aminophenyl)(phenyl)methylene)-4-nitroaniline.
abstract: Few novel transition metal complexes having N-((2-aminophenyl)(phenyl)methylene)-4-nitroaniline were synthesized and characterized by elemental analyses, IR, (1)H and (13)C NMR, electronic, EPR and mass spectra, conductivity and magnetic susceptibility measurements. All the metal complexes adopted square planar geometrical arrangements. The DNA-binding properties of the metal(II) complexes have been investigated by electronic absorption, fluorescence, CD spectra, cyclic voltammetry, differential pulse voltammogram and viscosity measurements. The results obtained indicate that these complexes bind to DNA via an intercalation binding mode. DNA cleavage activities indicate that the metal complexes exhibit greater activity than the ligand. The antimicrobial screening reveals that all the metal complexes exhibit better activity than the free ligand.
authors: Research Department of Chemistry, VHNSN College, Virudhunagar, 626 001, Tamil Nadu, India.
authors: Vellaichamy
authors: V
authors: Muniyandi
authors: Research Department of Chemistry, VHNSN College, Virudhunagar, 626 001, Tamil Nadu, India. Electronic address: ramchem1964@gmail.com.
authors: Natarajan
authors: N
authors: Raman
mesh_terms: D000814:Aniline Compounds / Q000138:chemical synthesis / Q000737:chemistry; D000890:Anti-Infective Agents / Q000138:chemical synthesis / Q000737:chemistry; D004247:DNA / Q000737:chemistry*; D009574:Nitro Compounds / Q000138:chemical synthesis / Q000737:chemistry
chemical_list: D000814:Aniline Compounds; D000890:Anti-Infective Agents; D009574:Nitro Compounds; D004247:DNA
keywords: Antimicrobial activity; DNA binding; Intercalation; Oxidative cleavage; Square planar