title: An attempt to construct a 7-item short version of the temperament and character inventory to predict the treatment response of patients with depression; a validation study.
abstract: The Temperament and Character Inventory (TCI) is a psychological test that is frequently used to assess personality traits. Many studies have shown the potential of the inventory to predict the treatment response of patients with major depressive disorder (MDD). Previously, we showed the association between 10 items of the TCI and the treatment response. In the present study, we reanalyzed the 10 items and aimed to provide cut-off values.
  
  
  
  This work is a secondary analysis of previously published work. Seventy-three patients were enrolled in the previously done study. Participants were treated with 10-40 mg/day of paroxetine for six weeks, and then the participants completed the TCI. The Montgomery-Asberg Depression Rating Scale (MADRS) was used to evaluate depression. The participants were divided into two groups (responders and non-responders). Using chi-squared tests, we reanalyzed the 10 items that had the strongest association with the treatment response in the previous study. We rated the answers to each item associated with the treatment response as a "1", and the answers associated with a non-response were rated as a "0". We calculated predictive scores using 10 models. Each model consisted of 1-10 scores of the best 1-10 items. We defined cut-off values for predicting treatment responses using a receiver operating characteristic (ROC) curve analysis.
  
  
  
  Ranked by the strength of the association with the treatment response, items 174, 137, 70, 237, 106, 191, 34, 232, 161, and 215 of the TCI significantly predicted treatment responses. All predictive scores from models 1 to 10 significantly predicted treatment responses. The predictive score threshold of model 7 was 3/4, with an area under the curve of 0.825, and this model showed the highest odds and likelihood ratios (19.3 and 8.86, respectively).
  
  
  
  We might predict the treatment response of patients with MDD using TCI predictive scoring, including items 174, 137, 70, 237, 106, 191, and 34 and a cut-off value of 3/4.
authors: Department of Neuropsychiatry, Graduate School of Medicine, Hirosaki University, Hirosaki, 036-8562, Japan. ttomita1984@yahoo.co.jp.
authors: Tetsu
authors: T
authors: Tomita
authors: Department of Neuropsychiatry, Graduate School of Medicine, Hirosaki University, Hirosaki, 036-8562, Japan.
authors: Norio
authors: N
authors: Yasui-Furukori
authors: Department of Neuropsychiatry, Graduate School of Medicine, Hirosaki University, Hirosaki, 036-8562, Japan.
authors: Ayako
authors: A
authors: Kaneda
authors: Department of Neuropsychiatry, Graduate School of Medicine, Hirosaki University, Hirosaki, 036-8562, Japan.|Department of Neuropsychiatry, Hirosaki-Aiseikai Hospital, Hirosaki, Japan.
authors: Masamichi
authors: M
authors: Ishioka
authors: Department of Neuropsychiatry, Graduate School of Medicine, Hirosaki University, Hirosaki, 036-8562, Japan.|Aomori Prefectural Center for Mental Health and Welfare, Aomori, Japan.
authors: Norio
authors: N
authors: Sugawara
authors: Department of Neuropsychiatry, Odate Municipal General Hospital, Odate, Japan.
authors: Taku
authors: T
authors: Nakagami
authors: Department of Neuropsychiatry, Graduate School of Medicine, Hirosaki University, Hirosaki, 036-8562, Japan.
authors: Kazuhiko
authors: K
authors: Nakamura
mesh_terms: D000328:Adult; D002605:Character; D003865:Major Depressive Disorder / Q000188:drug therapy / Q000523:psychology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D017374:Paroxetine / Q000627:therapeutic use; D010555:Personality Inventory; D011569:Psychiatric Status Rating Scales; D013694:Temperament; D016896:Treatment Outcome
chemical_list: D017374:Paroxetine
keywords: Antidepressants; Depression; Major depressive disorder; Paroxetine; Predict; Response; Temperament and character inventory