title: Myeloma bone disease: Progress in pathogenesis.
abstract: Myeloma bone disease (MBD) is one of the most serious complications of multiple myeloma (MM) and the most severe cause of MM morbidity. Dysregulation of osteoblast and osteoclast cells plays key roles in MBD. In the bone marrow microenvironment, myeloma cells, osteoblasts, osteoclasts and bone marrow stromal cells can secrete multiple cytokines, categorized as osteoclast cell activating factors (OAFs) and osteoblast cell inactivating factors, which have been discovered to participate in bone metabolism and contribute to the pathogenesis of MBD. Several signaling pathways related to these cytokines were also revealed in the MBD pathogenesis. To better understand the pathogenesis of MBD and therefore the potential therapeutic targets of this disease, we will summarize recent study progress in the factors and underlying signaling pathways involved in the occurrence and development of MBD.
authors: Department of Hematology, The Myeloma and Lymphoma Center, Changzheng Hospital, Second Military Medical University, Shanghai, China.
authors: Hao
authors: H
authors: Xi
authors: Department of Hematology, The Myeloma and Lymphoma Center, Changzheng Hospital, Second Military Medical University, Shanghai, China.
authors: Ran
authors: R
authors: An
authors: Department of Hematology, The Myeloma and Lymphoma Center, Changzheng Hospital, Second Military Medical University, Shanghai, China.
authors: Lu
authors: L
authors: Li
authors: Department of Physiology, Second Military Medical University, Shanghai, China.
authors: Gang
authors: G
authors: Wang
authors: Department of Hematology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China. Electronic address: smmu018@163.com.
authors: Yi
authors: Y
authors: Tao
authors: Department of Physiology, Second Military Medical University, Shanghai, China. Electronic address: Lu.gao@smmu.edu.cn.
authors: Lu
authors: L
authors: Gao
mesh_terms: D000818:Animals; D001847:Bone Diseases / Q000209:etiology* / Q000473:pathology; D001862:Bone Resorption / Q000209:etiology; D006801:Humans; D009101:Multiple Myeloma / Q000150:complications*; D010006:Osteoblasts / Q000473:pathology
keywords: Myeloma bone disease; Osteoblast; Osteoblast cell inactivating factor; Osteoclast; Osteoclast cell activating factor