title: Two Cases of Hepatosplenic T-Cell Lymphoma in Adolescents Treated for Autoimmune Hepatitis.
abstract: We report the first 2 cases of hepatosplenic T-cell lymphoma in adolescents diagnosed with autoimmune hepatitis under long-term treatment with azathioprine. Patients presented with fatigue, hepatosplenomegaly, and pancytopenia. The diagnosis could be confirmed performing biopsies of liver and spleen or bone marrow, which demonstrated infiltration of neoplastic T lymphocytes with the typical phenotype with both markers, CD56(+) and TCRγδ(+) Thus, these cases emphasize the need to constantly reevaluate the administered dose and duration of thiopurines for autoimmune hepatitis, especially in adolescents.
authors: Departments of Pediatrics, f.brinkert@uke.de.
authors: Florian
authors: F
authors: Brinkert
authors: 1st Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
authors: Philomena
authors: P
authors: Arrenberg
authors: Pathology, and.
authors: Till
authors: T
authors: Krech
authors: Departments of Pediatrics.
authors: Enke
authors: E
authors: Grabhorn
authors: 1st Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
authors: Ansgar
authors: A
authors: Lohse
authors: 1st Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
authors: Christoph
authors: C
authors: Schramm
mesh_terms: D000293:Adolescent; D001379:Azathioprine / Q000009:adverse effects* / Q000627:therapeutic use; D005260:Female; D019693:Hepatitis, Autoimmune / Q000150:complications / Q000188:drug therapy*; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects* / Q000627:therapeutic use; D008113:Liver Neoplasms / Q000139:chemically induced* / Q000175:diagnosis; D016399:Lymphoma, T-Cell / Q000139:chemically induced* / Q000175:diagnosis; D008297:Male; D013160:Splenic Neoplasms / Q000139:chemically induced* / Q000175:diagnosis
chemical_list: D007166:Immunosuppressive Agents; D001379:Azathioprine