title: Polyphenols from wolfberry and their bioactivities.
abstract: Nine new phenylpropanoids, one new coumarin, and 43 known polyphenols were isolated from wolfberry. Their structures were determined by spectroscopic analyses, chemical methods, and comparison of NMR data. Polyphenols, an important type of natural products, are notable constituents in wolfberry. 53 polyphenols, including 28 phenylpropanoids, four coumarins, eight lignans, five flavonoids, three isoflavonoids, two chlorogenic acid derivatives, and three other constituents, were identified from wolfberry. Lignans and isoflavonoids were firstly reported from wolfberry. 22 known polyphenols were the first isolates from the genus Lycium. This research presents a systematic study on wolfberry polyphenols, including their bioactivities. All these compounds exhibited oxygen radical absorbance capacity (ORAC), and some compounds displayed DPPH radical scavenging activity. One compound had acetylcholinesterase inhibitory activity. The discovery of new polyphenols and their bioactivities is beneficial for understanding the scientific basis of the effects of wolfberry.
authors: Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, People's Republic of China.
authors: Zheng-Qun
authors: ZQ
authors: Zhou
authors: Department of Immunobiology, Institute of Tissue Transplantation and Immunology, College of Life Science and Technology, Jinan University, Guangzhou 510632, People's Republic of China.
authors: Jia
authors: J
authors: Xiao
authors: Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, People's Republic of China.
authors: Hong-Xia
authors: HX
authors: Fan
authors: Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, People's Republic of China.
authors: Yang
authors: Y
authors: Yu
authors: Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, People's Republic of China.
authors: Rong-Rong
authors: RR
authors: He
authors: Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, People's Republic of China.
authors: Xiao-Lin
authors: XL
authors: Feng
authors: Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, People's Republic of China.
authors: Hiroshi
authors: H
authors: Kurihara
authors: Guangdong Medical Key Laboratory of Brain Function and Diseases, GMH Institute of Central Nervous System Regeneration, Jinan University, Guangzhou 510632, People's Republic of China.
authors: Kwok-Fai
authors: KF
authors: So
authors: Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, People's Republic of China. Electronic address: tyaoxs@jnu.edu.cn.
authors: Xin-Sheng
authors: XS
authors: Yao
authors: Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, People's Republic of China. Electronic address: tghao@jnu.edu.cn.
authors: Hao
authors: H
authors: Gao
mesh_terms: D000110:Acetylcholinesterase / Q000737:chemistry; D000544:Alzheimer Disease; D052160:Benzothiazoles; D001713:Biphenyl Compounds / Q000737:chemistry; D002726:Chlorogenic Acid / Q000032:analysis; D002800:Cholinesterase Inhibitors / Q000737:chemistry; D005419:Flavonoids / Q000032:analysis*; D005504:Food Analysis / Q000379:methods; D016166:Free Radical Scavengers / Q000737:chemistry*; D005609:Free Radicals / Q000737:chemistry; D017705:Lignans / Q000737:chemistry; D032305:Lycium / Q000737:chemistry*; D015394:Molecular Structure; D010100:Oxygen / Q000737:chemistry; D010851:Picrates / Q000737:chemistry; D010936:Plant Extracts / Q000737:chemistry; D059808:Polyphenols / Q000032:analysis*; D013056:Spectrophotometry, Ultraviolet; D013329:Structure-Activity Relationship; D013844:Thiazoles / Q000737:chemistry
chemical_list: D052160:Benzothiazoles; D001713:Biphenyl Compounds; D002800:Cholinesterase Inhibitors; D005419:Flavonoids; D016166:Free Radical Scavengers; D005609:Free Radicals; D017705:Lignans; D010851:Picrates; D010936:Plant Extracts; D059808:Polyphenols; D013844:Thiazoles; C009462:thioflavin T; D002726:Chlorogenic Acid; C004931:1,1-diphenyl-2-picrylhydrazyl; D000110:Acetylcholinesterase; D010100:Oxygen
keywords: DPPH radical scavenging assay; Ellman method; Lycium barbarum; ORAC assay; Polyphenols; Structural identification; ThT assay; Wolfberry