title: Downregulation of miR-3940-5p promotes T-cell activity by targeting the cytokine receptor IL-2R gamma on human cutaneous T-cell lines.
abstract: Vitiligo is a common established depigmentation skin disease characterized by the presence of activated T lymphocytes anti melanocytes within the skin. T-cell immunity mainly mediates the destruction of melanocytes and is one of the main mechanisms involved in the pathogenesis of non-segmental vitiligo. Our previous study had identified several differentially expressed miRNAs and found that the expression of miR-3940-5p was downregulated in vitiligo patients. According to the research findings, we hypothesized that the novel miRNA plays a potential role on human cutaneous T lymphocytes in the action mechanism of immune imbalance in vitiligo.
authors: Department of Dermatology, Jinan Central Hospital Affiliated to Shandong University, Jinan, China.
authors: Yi
authors: Y
authors: Wang
authors: Department of Dermatology, Qilu Hospital of Shandong University, Jinan, China. Electronic address: wangkeyu@medmail.com.cn.
authors: Keyu
authors: K
authors: Wang
authors: Department of Dermatology, Jinan Central Hospital Affiliated to Shandong University, Jinan, China.
authors: Ningning
authors: N
authors: Dang
authors: Department of Dermatology, Jinan Central Hospital Affiliated to Shandong University, Jinan, China.
authors: Lihua
authors: L
authors: Wang
authors: Department of Dermatology, Jinan Central Hospital Affiliated to Shandong University, Jinan, China.
authors: Min
authors: M
authors: Zhang
mesh_terms: D002460:Cell Line; D003198:Computer Simulation; D030541:Databases, Genetic; D015536:Down-Regulation; D005786:Gene Expression Regulation; D006801:Humans; D053631:Interleukin Receptor Common gamma Subunit / Q000235:genetics* / Q000378:metabolism; D008213:Lymphocyte Activation; D008544:Melanocytes / Q000276:immunology*; D035683:MicroRNAs / Q000235:genetics*; D015398:Signal Transduction; D012867:Skin / Q000473:pathology*; D013601:T-Lymphocytes / Q000276:immunology*; D014820:Vitiligo / Q000276:immunology*
chemical_list: C507941:IL2RG protein, human; D053631:Interleukin Receptor Common gamma Subunit; C581631:MIRN3940 microRNA, human; D035683:MicroRNAs
keywords: Cellular immunity; Cytokine receptor; Non-segmental vitiligo; microRNA