title: Adult-onset stereotypical motor behaviors.
abstract: Stereotypies have been defined as non-goal-directed movement patterns repeated continuously for a period of time in the same form and on multiple occasions, and which are typically distractible. Stereotypical motor behaviors are a common clinical feature of a variety of neurological conditions that affect cortical and subcortical functions, including autism, tardive dyskinesia, excessive dopaminergic treatment of Parkinson's disease and frontotemporal dementia. The main differential diagnosis of stereotypies includes tic disorders, motor mannerisms, compulsion and habit. The pathophysiology of stereotypies may involve the corticostriatal pathways, especially the orbitofrontal and anterior cingulated cortices. Because antipsychotics have long been used to manage stereotypical behaviours in mental retardation, stereotypies that present in isolation tend not to warrant pharmacological intervention, as the benefit-to-risk ratio is not great enough.
authors: Department of Neurology, Rouen University Hospital, University of Rouen, 1, rue de Germont, 76031 cedex Rouen, France; Inserm U 1073, 22, boulevard Gambetta, 76183 Rouen cedex, France. Electronic address: david.maltete@chu-rouen.fr.
authors: D
authors: D
authors: Maltête
mesh_terms: D000328:Adult; D017668:Age of Onset; D003192:Compulsive Behavior / Q000175:diagnosis / Q000209:etiology / Q000628:therapy; D003937:Diagnosis, Differential; D057180:Frontotemporal Dementia / Q000175:diagnosis / Q000209:etiology / Q000628:therapy; D006801:Humans; D013239:Stereotyped Behavior / Q000502:physiology; D019956:Stereotypic Movement Disorder / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology / Q000628:therapy; D000071057:Tardive Dyskinesia / Q000175:diagnosis / Q000209:etiology / Q000628:therapy
keywords: Adult; Adulte; Dyskinésie tardive; Démence frontotemporale; Frontotemporal dementia; Stereotypy; Stéréotypie; Tardive dyskinesia; Traitement; Treatment