title: Obesity and novel cardiovascular markers in a population without diabetes and cardiovascular disease in China.
abstract: To investigate associations of novel cardiovascular markers with obesity in a general population.
  
  
  
  A total of 9361 individuals without diabetes or cardiovascular disease were studied between 2009 and 2012 in China. High-sensitivity cardiac troponin T (hs-cTnT), N-terminal pro-B-type natriuretic peptide (NT-proBNP), brachial-ankle pulse wave velocity (baPWV), pulse pressure, and central systolic blood pressure (cSBP) were assessed according to body mass index (BMI) levels and different BMI/metabolic syndrome (MetS) combinations.
  
  
  
  'Levels of hs-cTnT, baPWV, pulse pressure, and cSBP increased across BMI levels. Obesity was positively associated with these markers in multivariate models (P<0.05 for all). When stratified by MetS, these associations remained significant in the non-MetS group, and compared with normal weight participants, the obese participants had 1.87 (95% confidence interval: 1.48, 2.36), 1.27 (1.02, 1.57), 1.89 (1.39, 2.57), and 2.71 (2.11, 3.47) fold risks for having elevated hs-cTnT, baPWV, pulse pressure, and cSBP, respectively, and had 1.61 (1.26, 2.05), 1.75 (1.27, 2.42), 2.45 (1.46, 4.11), and 3.14 (2.13, 4.62) fold risks for having 1, 2, 3, and 4 elevated cardiovascular markers, respectively; while no relationship was observed between obesity and these novel markers in the MetS group, after multivariate adjustment. These results were unchanged when using a waist-hip ratio, body fat per cent, and visceral adiposity index to redefine obesity.
  
  
  
  Obesity was positively associated with novel cardiovascular markers (except NT-proBNP) in participants without MetS rather than in participants with MetS. Obese participants without MetS also had higher odds of having more number of elevated cardiovascular markers.
authors: Health Management Institute, Chinese PLA General Hospital, Beijing 100853, China. Electronic address: zq301@126.com.
authors: Qiang
authors: Q
authors: Zeng
authors: Healthcare Department, Agency for Offices Administration of PLA, Beijing 100034, China.
authors: Sheng-Yong
authors: SY
authors: Dong
authors: Center of Biomedical Analysis, Tsinghua University, Beijing 100084, China.
authors: Man-Liu
authors: ML
authors: Wang
authors: Healthcare Department, Agency for Offices Administration of PLA, Beijing 100034, China.
authors: Jin-Ming
authors: JM
authors: Li
authors: Department of Cardiovascular Surgery, Chinese PLA General Hospital, Beijing 100853, China.
authors: Chong-Lei
authors: CL
authors: Ren
authors: Department of Cardiovascular Surgery, Chinese PLA General Hospital, Beijing 100853, China. Electronic address: gaochq301@yahoo.com.
authors: Chang-Qing
authors: CQ
authors: Gao
mesh_terms: D055109:Ankle Brachial Index; D015415:Biomarkers / Q000097:blood*; D001794:Blood Pressure; D015992:Body Mass Index; D002318:Cardiovascular Diseases / Q000097:blood* / Q000517:prevention & control; D002681:China / Q000453:epidemiology; D003920:Diabetes Mellitus; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000453:epidemiology*; D011795:Surveys and Questionnaires; D020107:Troponin T / Q000097:blood
chemical_list: D015415:Biomarkers; D020107:Troponin T
keywords: Cardiovascular marker; Metabolic syndrome; Obesity; Pulse wave velocity; Troponin T