title: Clinicopathological Features and Survival Rate of Colorectal Adenocarcinoma Patients with and without a KRAS Mutation: a FiveYear Study in Yazd, Iran.
abstract: BACKGROUND
  By some estimates, colorectal carcinoma is the third most common cancer worldwide. The most appropriate method of treatment, especially of its metastatic form, is determined based on KRAS status. The present study was conducted on patients with colorectal cancer positive or neagtive for a KRAS mutation in terms of survival rate and the response to treatment.
  
  
  METHODS
  Medical records of all cases with colorectal cancer hospitalized from 2010 to 2015 and with KRAS testing results were studied. Data such as gender, age, tumor (size, grade, location, stage), treatment type, KRAS status and survival were considered as variables. Survival analysis was performed using the KaplanMeier method and Logrank test. Statistical significance level was defined as P value <0.05.
  
  
  RESULTS
  Out of 90 patients, 55 (61.2%) were male and 35(38.8%) were female with the age range of 2287 years. The overall disease specific survival was 53±3 (Mean ± SE) months with 95%CI:4760, and there were statistically significant differences between the mean survival rate with tumor stage and the response to treatment (log rank test, PV=0.007 and PV=0.001) respectively. The risk of mortality was 2.02 times higher in patients with mutant KRAS compared to those with the wild type of the gene; however, this difference was not statistically significant (OR=2.016; 95%CI: 0.685.9; PV=0.197).
  
  
  CONCLUSIONS
  In our study the overall 5year disease specific survival rate was low as compared to similar studies elsewhere. Significant correlations were found between survival time with treatment type and tumor stage.
authors: Shokouh Taghipour Zahir, Pathology department, Shahid Sadoughi University of medical sciences, Yazd, Iran Email : taghipour@ssu.ac.ir, taghipourzahirsh@gmail.com.
authors: Shokouh Taghipour
authors: ST
authors: Zahir
authors: Mohammadreza
authors: M
authors: NazemianYazdi
authors: Peyman
authors: P
authors: Arasteh
authors: Mohammadreza
authors: M
authors: Mortazavizadeh
authors: Mohammad
authors: M
authors: Karbalaeian
authors: Malihe
authors: M
authors: ZareMehrjardi
mesh_terms: D000230:Adenocarcinoma / Q000235:genetics* / Q000401:mortality / Q000473:pathology*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015179:Colorectal Neoplasms / Q000235:genetics* / Q000401:mortality / Q000473:pathology*; D005260:Female; D006801:Humans; D007492:Iran / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D009154:Mutation / Q000235:genetics; D009367:Neoplasm Staging / Q000379:methods; D016283:Proto-Oncogene Proteins p21(ras) / Q000235:genetics*; D016019:Survival Analysis; D015996:Survival Rate; D055815:Young Adult
chemical_list: C117307:KRAS protein, human; D016283:Proto-Oncogene Proteins p21(ras)