title: H-NS: an overarching regulator of the Vibrio cholerae life cycle.
abstract: Vibrio cholerae has become a model organism for studies connecting virulence, pathogen evolution and infectious disease ecology. The coordinate expression of motility, virulence and biofilm enhances its pathogenicity, environmental fitness and fecal-oral transmission. The histone-like nucleoid structuring protein negatively regulates gene expression at multiple phases of the V. cholerae life cycle. Here we discuss: (i) the regulatory and structural implications of H-NS chromatin-binding in the two-chromosome cholera bacterium; (ii) the factors that counteract H-NS repression; and (iii) a model for the regulation of the V. cholerae life cycle that integrates H-NS repression, cyclic diguanylic acid signaling and the general stress response.
authors: Morehouse School of Medicine, Department of Microbiology, Biochemistry and Immunology, Atlanta, GA, USA; University of Alabama at Birmingham, Department of Microbiology, Birmingham, AL, USA.
authors: Julio C
authors: JC
authors: Ayala
authors: Morehouse School of Medicine, Department of Microbiology, Biochemistry and Immunology, Atlanta, GA, USA. Electronic address: asilva-benitez@msm.edu.
authors: Anisia J
authors: AJ
authors: Silva
authors: Morehouse School of Medicine, Department of Microbiology, Biochemistry and Immunology, Atlanta, GA, USA. Electronic address: jbenitez@msm.edu.
authors: Jorge A
authors: JA
authors: Benitez
mesh_terms: D001426:Bacterial Proteins / Q000378:metabolism*; D018441:Biofilms / Q000254:growth & development; D002843:Chromatin / Q000378:metabolism; D004268:DNA-Binding Proteins / Q000378:metabolism*; D015964:Gene Expression Regulation, Bacterial; D008124:Locomotion; D011485:Protein Binding; D014734:Vibrio cholerae / Q000235:genetics* / Q000502:physiology*; D014774:Virulence
chemical_list: D001426:Bacterial Proteins; D002843:Chromatin; D004268:DNA-Binding Proteins; C031908:H-NS protein, bacteria
keywords: H-NS; Life cycle; Vibrio cholerae