title: The protective effect of Capparis ovata in acute hepatotoxicity induced by paracetamol.
abstract: OBJECTIVE
  To investigate the efficiency of Capparis ovata as a protective agent against acute paracetamol toxicity of the liver.
  
  
  METHODS
  A total of 36 Wistar albino rats were divided into 4 groups: 1) paracetamol, 2) Capparis ovata + paracetamol, 3) Capparis ovata, and 4) control. Groups 2 and 3 were given Capparis ovata and Groups 1 and 4 distilled water for 8 days. On day 8, 3000 mg kg-1 paracetamol was administered orally to Groups 1 and 2. Samples were taken on day 9. AST, ALT, total bilirubin, direct bilirubin, GGT, and ALP levels were assessed. Lipid peroxidation markers and thiobarbituric acid-reactive substance (TBARS) levels were measured in the blood and liver. Liver tissues were evaluated histologically.
  
  
  RESULTS
  AST, ALT, and total bilirubin levels were lower in Group 2 than in Group 1 (P < 0.05). TBARS levels were lower in Groups 2 (P = 0.000), 3 (P = 0.001), and 4 (P = 0.001) than in Group 1. Degenerative findings were lower in the Capparis ovata + paracetamol group than in the paracetamol group (P < 0.05).
  
  
  CONCLUSIONS
  It can be concluded that Capparis ovata has a protective effect on the liver, both histopathologically and biochemically, against paracetamol-induced liver injury.
authors: Department of Pediatrics, Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Faculty of Medicine,Süleyman Demirel University, Isparta, Turkey.
authors: Nurcan
authors: N
authors: Dogan
authors: Department of Pediatrics, Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Faculty of Medicine,Süleyman Demirel University, Isparta, Turkey.
authors: Mustafa
authors: M
authors: Akçam
authors: Department of Pediatrics, Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Faculty of Medicine,Süleyman Demirel University, Isparta, Turkey.
authors: Tuğba
authors: T
authors: Koca
authors: Department of Biochemistry, Faculty of Medicine, Süleyman Demirel University, Isparta, Turkey.
authors: Duygu
authors: D
authors: Kumbul Doğuç
authors: Department of Histology, Faculty of Medicine, Süleyman Demirel University, Isparta, Turkey.
authors: Meltem
authors: M
authors: Özgöçmen
mesh_terms: D000082:Acetaminophen; D000818:Animals; D031484:Capparis; D056486:Chemical and Drug Induced Liver Injury; D008099:Liver; D010936:Plant Extracts; D051381:Rats; D017208:Rats, Wistar; D023382:Toxicity Tests, Acute
chemical_list: D010936:Plant Extracts; D000082:Acetaminophen
keywords: Antioxidant; Capparis ovata; hepatotoxicity; paracetamol