title: Lycopene inhibits the cell proliferation and invasion of human head and neck squamous cell carcinoma.
abstract: Lycopene has been shown to be associated with anticancer effects in numerous tumor types. However, the underlying mechanisms of lycopene in human head and neck squamous cell carcinoma (HNSCC) remain to be determined. The present study aimed to investigate the involvement of lycopene overload and the cytotoxic effects of lycopene on HNSCC cells, and to determine the possible mechanisms involved. Treatment with lycopene at a dose of >10 µM for >24 h inhibited the growth of FaDu and Cal27 cells in a time‑ and dose‑dependent manner. The clearest increase in growth inhibition was due to the apoptotic population being significantly increased. The invasion abilities decreased with 25 µM lycopene exerting significant inhibitory effects (P<0.01). Mechanistic studies revealed that lycopene induced the upregulation of the pro‑apoptotic protein, B‑cell lymphoma‑associated X protein, and therefore, resulted in the inhibition of the protein kinase B and mitogen‑activated protein kinase signaling pathway. These data provided insights into the antitumor activity of lycopene in HNSCC cells.
authors: Department of Biopharmacy, School of Pharmacy, Fujian Medical University, Fuzhou, Fujian 350004, P.R. China.
authors: Min
authors: M
authors: Ye
authors: Department of Biopharmacy, School of Pharmacy, Fujian Medical University, Fuzhou, Fujian 350004, P.R. China.
authors: Qundan
authors: Q
authors: Wu
authors: Department of Biopharmacy, School of Pharmacy, Fujian Medical University, Fuzhou, Fujian 350004, P.R. China.
authors: Min
authors: M
authors: Zhang
authors: Department of Urology, The First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian 350004, P.R. China.
authors: Jinbei
authors: J
authors: Huang
mesh_terms: D016588:Anticarcinogenic Agents / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy* / Q000473:pathology; D002338:Carotenoids / Q000494:pharmacology*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects*; D006258:Head and Neck Neoplasms / Q000188:drug therapy* / Q000473:pathology; D006801:Humans; D000077276:Lycopene; D009361:Neoplasm Invasiveness / Q000473:pathology / Q000517:prevention & control*
chemical_list: D016588:Anticarcinogenic Agents; D002338:Carotenoids; D000077276:Lycopene