title: Mechanized azobenzene-functionalized zirconium metal-organic framework for on-command cargo release.
abstract: Stimuli-responsive metal-organic frameworks (MOFs) have gained increasing attention recently for their potential applications in many areas. We report the design and synthesis of a water-stable zirconium MOF (Zr-MOF) that bears photoresponsive azobenzene groups. This particular MOF can be used as a reservoir for storage of cargo in water, and the cargo-loaded MOF can be further capped to construct a mechanized MOF through the binding of β-cyclodextrin with the azobenzene stalks on the MOF surface. The resulting mechanized MOF has shown on-command cargo release triggered by ultraviolet irradiation or addition of competitive agents without premature release. This study represents a simple approach to the construction of stimuli-responsive mechanized MOFs, and considering mechanized UiO-68-azo made from biocompatible components, this smart system may provide a unique MOF platform for on-command drug delivery in the future.
authors: Key Laboratory of Biomedical Polymers of Ministry of Education, College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072, China.
authors: Xiangshi
authors: X
authors: Meng
authors: Key Laboratory of Biomedical Polymers of Ministry of Education, College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072, China.
authors: Bo
authors: B
authors: Gui
authors: State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou 350002, China.
authors: Daqiang
authors: 0000-0003-4627-072X
authors: D
authors: Yuan
authors: Department of Chemistry, Purdue University, 560 Oval Drive, West Lafayette, IN 47907, USA.
authors: Matthias
authors: 0000-0002-3305-852X
authors: M
authors: Zeller
authors: Key Laboratory of Biomedical Polymers of Ministry of Education, College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072, China.
authors: Cheng
authors: C
authors: Wang
mesh_terms: D001391:Azo Compounds / Q000737:chemistry*; D004337:Drug Carriers / Q000737:chemistry; D016503:Drug Delivery Systems; D008958:Models, Molecular; D009942:Organometallic Compounds / Q000737:chemistry*; D066244:Proton Magnetic Resonance Spectroscopy; D014867:Water / Q000737:chemistry; D014961:X-Ray Diffraction; D015040:Zirconium / Q000737:chemistry*
chemical_list: D001391:Azo Compounds; D004337:Drug Carriers; D009942:Organometallic Compounds; D014867:Water; D015040:Zirconium; C009850:azobenzene
keywords: Metal-organic framework; azobenzene; on-command release; supramolecular complex; zirconium