title: Highlights From the American Association of Pharmaceutical Scientists/ International Transporter Consortium Joint Workshop on Drug Transporters in Absorption, Distribution, Metabolism, and Excretion: From the Bench to the Bedside - Clinical Pharmacology Considerations.
abstract: The American Association of Pharmaceutical Scientists/International Transporter Consortium Joint Workshop on Drug Transporters in absorption, distribution, metabolism, and excretion was held with the objective of discussing innovative advances in transporter pharmacology. Specific topics included (i) transporters at the blood-brain barrier (BBB); (ii) emerging transport proteins; (iii) recent advances in achieving hepatoselectivity and optimizing clearance for organic anion-transporting polypeptide (OATP) substrates; (iv) utility of animal models for transporter studies; and (v) clinical correlation of transporter polymorphisms. Here, we present state-of-the-art highlights from this workshop in these key areas of focus.
authors: Department of Pharmacology, College of Medicine, University of Arizona, Tucson, Arizona, USA. pronald@email.arizona.edu.
authors: P T
authors: PT
authors: Ronaldson
authors: University of Kentucky, Lexington, Kentucky, USA.
authors: B
authors: B
authors: Bauer
authors: Pfizer, Cambridge, Massachusetts, USA.
authors: A F
authors: AF
authors: El-Kattan
authors: Bristol-Myers Squibb, Princeton, New Jersey, USA.
authors: H
authors: H
authors: Shen
authors: Genentech, South San Francisco, California, USA.
authors: L
authors: L
authors: Salphati
authors: Amgen, Cambridge, Massachusetts, USA.
authors: S W
authors: SW
authors: Louie
mesh_terms: D000818:Animals; D001812:Blood-Brain Barrier / Q000378:metabolism*; D006801:Humans; D026901:Membrane Transport Proteins / Q000235:genetics / Q000378:metabolism*; D023421:Models, Animal; D027361:Organic Anion Transporters / Q000378:metabolism*; D014481:United States
chemical_list: D026901:Membrane Transport Proteins; D027361:Organic Anion Transporters