title: In Vivo Bioorthogonal Chemistry Enables Local Hydrogel and Systemic Pro-Drug To Treat Soft Tissue Sarcoma.
abstract: The ability to activate drugs only at desired locations avoiding systemic immunosuppression and other dose limiting toxicities is highly desirable. Here we present a new approach, named local drug activation, that uses bioorthogonal chemistry to concentrate and activate systemic small molecules at a location of choice. This method is independent of endogenous cellular or environmental markers and only depends on the presence of a preimplanted biomaterial near a desired site (e.g., tumor). We demonstrate the clear therapeutic benefit with minimal side effects of this approach in mice over systemic therapy using a doxorubicin pro-drug against xenograft tumors of a type of soft tissue sarcoma (HT1080).
authors: Shasqi Inc., 665 Third Street, Suite 250, San Francisco, California 94107, United States.
authors: Jose M
authors: JM
authors: Mejia Oneto
authors: University at Albany , Department of Chemistry, 1400 Washington Avenue, Albany, New York 12222, United States.
authors: Irfan
authors: I
authors: Khan
authors: University at Albany , Department of Chemistry, 1400 Washington Avenue, Albany, New York 12222, United States.
authors: Leah
authors: L
authors: Seebald
authors: University at Albany , Department of Chemistry, 1400 Washington Avenue, Albany, New York 12222, United States.
authors: Maksim
authors: M
authors: Royzen