title: Design and development of Albizia stipulata gum based controlled-release matrix tablets in cancer therapeutics.
abstract: The present study deals with the development of natural macromolecule gum Albizia stipulata (AS) based novel pharmaceutical excipient for the controlled-release of paracetamol (PC). Central composite design (CCD) two-factor, five-level was used for the optimization of independent variables AS gum and compression force (CF) based on desired response variable drug release (DR) of paracetamol matrix tablets (PCMT). The optimized PCMT was prepared by wet granulation method and screened for pre- and post- compression parameters, and were characterized. The optimized PCMT (F14) formulation showed favorable in vitro release of PC (65%) in 12h, and the release kinetics followed zero order anomalous diffusion mechanism. AS gum exerted significant (p<0.001) anticancer activity with 98.25% inhibition at 2000μg/mL (IC50=179.12μg/mL) against A549 cell line. PC and PCMT showed 78.56% inhibition (IC50value=856.58μg/mL) and 93.68% inhibition (IC50value=396.35μg/mL) respectively, symbolizing that the gum remarkably potentiated the anticancer effect of PC in formulation after 24h treatment by inducing apoptosis. This is the first report on A. stipulata gum as a promising biopolymer for drug delivery application in cancer therapeutics.
authors: Department of Pharmaceutical Technology, Centre for Excellence in Nanobio Translational Research (CENTRE), Bharathidasan Institute of Technology, Anna University, Tiruchirappalli 620024, Tamil Nadu, India.
authors: Veenus Seelan
authors: VS
authors: T
authors: Department of Pharmaceutical Technology, Centre for Excellence in Nanobio Translational Research (CENTRE), Bharathidasan Institute of Technology, Anna University, Tiruchirappalli 620024, Tamil Nadu, India; National Facility for Drug Development (NFDD) for Academia, Pharmaceutical and Allied Industries, Bharathidasan Institute of Technology, Anna University, Tiruchirappalli 620024, Tamil Nadu, India.
authors: Linda Jeeva Kumari
authors: LJ
authors: Henry
authors: Department of Pharmaceutical Technology, Centre for Excellence in Nanobio Translational Research (CENTRE), Bharathidasan Institute of Technology, Anna University, Tiruchirappalli 620024, Tamil Nadu, India.
authors: Kishore
authors: K
authors: Narra
authors: Department of Pharmacy, Regional Institute of Paramedical and Nursing Sciences (RIPANS), Zemabawk, Aizawl 796017, Mizoram, India. Electronic address: aduhapc@gmail.com.
authors: Pachuau
authors: P
authors: Lalduhsanga
authors: Department of Pharmaceutical Technology, Centre for Excellence in Nanobio Translational Research (CENTRE), Bharathidasan Institute of Technology, Anna University, Tiruchirappalli 620024, Tamil Nadu, India; National Facility for Drug Development (NFDD) for Academia, Pharmaceutical and Allied Industries, Bharathidasan Institute of Technology, Anna University, Tiruchirappalli 620024, Tamil Nadu, India. Electronic address: hodpharma@gmail.com.
authors: Ruckmani
authors: R
authors: Kandasamy
mesh_terms: D000072283:A549 Cells; D000082:Acetaminophen / Q000494:pharmacology; D031289:Albizzia / Q000737:chemistry*; D000704:Analysis of Variance; D000970:Antineoplastic Agents / Q000494:pharmacology / Q000627:therapeutic use*; D002152:Calorimetry, Differential Scanning; D016923:Cell Death / Q000187:drug effects; D048430:Cell Shape / Q000187:drug effects; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D003692:Delayed-Action Preparations / Q000494:pharmacology; D065546:Drug Liberation; D006801:Humans; D007700:Kinetics; D009369:Neoplasms / Q000188:drug therapy* / Q000473:pathology; D053149:Plant Gums / Q000737:chemistry*; D017550:Spectroscopy, Fourier Transform Infrared; D013607:Tablets; D014961:X-Ray Diffraction
chemical_list: D000970:Antineoplastic Agents; D003692:Delayed-Action Preparations; D053149:Plant Gums; D013607:Tablets; D000082:Acetaminophen
keywords: Albizia stipulata gum; Anticancer; Controlled drug release; Matrix tablet; Paracetamol