title: Anxiety is associated with freezing of gait and attentional set-shifting in Parkinson's disease: A new perspective for early intervention.
abstract: Previous research has shown that anxiety in Parkinson's disease (PD) is associated with freezing of gait (FOG), and may even contribute to the underlying mechanism. However, limited research has investigated whether PD patients with FOG (PD+FOG) have higher anxiety levels when compared directly to non-freezing PD patients (PD-NF) and moreover, how anxiety might contribute to FOG. The current study evaluated whether: (i) PD+FOG have greater anxiety compared to PD-NF, and (ii) anxiety in PD is related to attentional set-shifting, in order to better understand how anxiety might be contributing to FOG. In addition, we explored whether anxiety levels differed between those PD patients with mild FOG (PD+MildFOG) compared to PD-NF. Four hundred and sixty-one patients with PD (231 PD-NF, 180 PD+FOG, 50 PD+MildFOG) were assessed using the Freezing of Gait Questionnaire item 3 (FOG-Q3), Hospital Anxiety and Depression Scale (HADS), Digit Span Test, Logical Memory Retention Test and Trail Making Tests. Compared to PD-NF, PD+FOG had significantly greater anxiety (p<0.001). PD+MildFOG, however, demonstrated similar levels of anxiety as the PD+FOG. In all patients, the severity of anxiety symptoms was significantly correlated to their degree of self-reported FOG on FOG-Q3 (p<0.001) and TMT B-A (p=0.039). Similar results were found for depression. In conclusion, these results confirm the key role played by anxiety in FOG and also suggest that anxiety might be a promising biomarker for FOG. Future research should consider whether treating anxiety with pharmacological and/or cognitive behavioural therapies at early stages of gait impairment in PD may alleviate troublesome FOG.
authors: Parkinson's Disease Research Clinic, Brain and Mind Centre, University of Sydney, 100 Mallet Street, Camperdown, New South Wales, 2050, Australia. Electronic address: Kaylena.ehgoetzmartens@sydney.edu.au.
authors: K A Ehgoetz
authors: KAE
authors: Martens
authors: Parkinson's Disease Research Clinic, Brain and Mind Centre, University of Sydney, 100 Mallet Street, Camperdown, New South Wales, 2050, Australia; School of Social Sciences and Psychology, Western Sydney University, Horsley Rd & Bullecourt Road, Milperra New South Wales, 2214, Australia.
authors: J M
authors: JM
authors: Hall
authors: Parkinson's Disease Research Clinic, Brain and Mind Centre, University of Sydney, 100 Mallet Street, Camperdown, New South Wales, 2050, Australia.
authors: M
authors: M
authors: Gilat
authors: Parkinson's Disease Research Clinic, Brain and Mind Centre, University of Sydney, 100 Mallet Street, Camperdown, New South Wales, 2050, Australia.
authors: M J
authors: MJ
authors: Georgiades
authors: Parkinson's Disease Research Clinic, Brain and Mind Centre, University of Sydney, 100 Mallet Street, Camperdown, New South Wales, 2050, Australia.
authors: C C
authors: CC
authors: Walton
authors: Parkinson's Disease Research Clinic, Brain and Mind Centre, University of Sydney, 100 Mallet Street, Camperdown, New South Wales, 2050, Australia.
authors: S J G
authors: SJG
authors: Lewis
mesh_terms: D000368:Aged; D001007:Anxiety / Q000150:complications* / Q000628:therapy; D001288:Attention; D005260:Female; D020233:Gait Disorders, Neurologic / Q000209:etiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000523:psychology*; D057566:Self Report; D011795:Surveys and Questionnaires
keywords: Anxiety; Attention; Freezing of gait; Parkinson’s disease; Set-shifting