title: Applicability of Radioguided Occult Lesion Localization for NonPalpable Benign Breast Lesions, Comparison with Wire Localization, a Clinical Trial.
abstract: BACKGROUND
  This study was designed to compare radioguided versus routine wire localization of non palpable nonmalignant breast lesions in terms of efficacy for complete excision, ease of use, time saving, and cosmetic outcome.
  
  
  METHODS
  Patients with nonpalpable breast masses and nonmalignant core biopsy results who were candidates for complete surgical lumpectomy were enrolled and randomly assigned to radioguided or wire localization groups. Radiologic, surgical, and pathologic data were collected and analyzed to determine the difficulty and duration of each procedure, ease of use, accuracy, and cosmetic outcomes.
  
  
  RESULTS
  This prospective randomized study included 60 patients, randomly divided into wire guided localization (WGL) or radioguided occult lesion localization (ROLL) groups. The mean duration of localization under ultrasound guidance was shorter in the ROLL group (14.4 min) than in the WGL group (16.5 min) (p<0.001). The ROLL method was significantly easier for radiologists (p=0.0001). The mean duration of the surgical procedure was 22.6 min (±10.3 min) for ROLL and 23.6 min (± 9.6 min) for WGL (p=0.6), a nonsignificant difference. Radiography of the surgical specimens showed 100% lesion excision with clear margins, as proved by pathologic examination, with both techniques. The surgical specimens were slightly heavier in the ROLL group, but the difference was not significant (p=0.06).
  
  
  CONCLUSIONS
  The ROLL technique provides effective, fast, and simple localization and excision of nonpalpable nonmalignant breast lesions.
authors: Cancer Research Center, Cancer Institute of Iran, Tehran University of Medical Sciences, Tehran, Iran Email : afsanehalikhassi@yahoo.co.uk.
authors: Afsaneh
authors: A
authors: Alikhassi
authors: Farzanefar
authors: F
authors: Saeed
authors: Mehrshad
authors: M
authors: Abbasi
authors: Ramesh
authors: R
authors: Omranipour
authors: Habibollah
authors: H
authors: Mahmoodzadeh
authors: Massoome
authors: M
authors: Najafi
authors: Masoumeh
authors: M
authors: Gity
authors: Ali
authors: A
authors: Kheradmand
mesh_terms: D001943:Breast Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008198:Lymph Nodes / Q000000981:diagnostic imaging* / Q000473:pathology*; D008327:Mammography / Q000379:methods; D015412:Mastectomy, Segmental; D009367:Neoplasm Staging; D011379:Prognosis; D011446:Prospective Studies; D015641:Radiography, Interventional / Q000379:methods; D019275:Radiopharmaceuticals
chemical_list: D019275:Radiopharmaceuticals