title: Regulation of Plexin: A Ring of Structural Twists and Turns.
abstract: The regulation of the guidance receptor plexin is incompletely understood. In this issue, Kong et al. (2016) present crystal structures of the full-length extracellular region of class A plexins, revealing its dual role in both autoinhibition and activation.
authors: Department of Pharmacology, University of Texas Southwestern Medical Center, 6001 Forest Park Road, Dallas, TX 75390, USA.
authors: Yi-Chun
authors: YC
authors: Kuo
authors: Department of Pharmacology, University of Texas Southwestern Medical Center, 6001 Forest Park Road, Dallas, TX 75390, USA. Electronic address: xuewu.zhang@utsouthwestern.edu.
authors: Xuewu
authors: X
authors: Zhang
mesh_terms: D015815:Cell Adhesion Molecules / Q000737:chemistry*; D009419:Nerve Tissue Proteins / Q000737:chemistry*; D011956:Receptors, Cell Surface / Q000737:chemistry; D039961:Semaphorins; D015398:Signal Transduction
chemical_list: D015815:Cell Adhesion Molecules; D009419:Nerve Tissue Proteins; D011956:Receptors, Cell Surface; D039961:Semaphorins; C091529:plexin
keywords: activation; autoinhibition; axon guidance; dimerization; plexin; structure