title: Morin, a Flavonoid from Moraceae, Inhibits Cancer Cell Adhesion to Endothelial Cells and EMT by Downregulating VCAM1 and Ncadherin.
abstract: Morin, a flavonoid found in figs and other Moraceae species, displays a variety of biological actions, exerting antioxidant, antiinflammatory and anticarcinogenic effects. Here, we investigated the anticancer activity of morin focusing on antiadhesive influence. We performed experiments with MDAMB231 human breast cancer cells. Morin inhibited TNFinduced cancer cell adhesion to human umbilical vein endothelial cells (HUVECs) without showing any toxicity. It further inhibited the expression of VCAM1 on MDAMB231 cells as well as HUVECs. Morin also decreased the expression of Ncadherin on MDAMB231 cells. In addition, there was apparent antimetastatic activity in vivo. In conclusion, this study suggested that morin inhibits cancer cell adhesion to HUVECs by reducing VCAM1, and EMT by targeting Ncadherin, and that it features antimetastatic activity in vivo. Further investigation of possible antimetastatic activity of morin against human breast cancer cells is warranted.
authors: Departments of Pathology, Institute of Health Sciences, Gyeongsang National University School of Medicine, Jinju, South Korea Email : lwshmo@gnu.ac.kr or kim HJ, hyejungkim@gnu.ac.kr.
authors: JeongHee
authors: J
authors: Lee
authors: Hana
authors: H
authors: Jin
authors: Won Sup
authors: WS
authors: Lee
authors: Arulkumar
authors: A
authors: Nagappan
authors: Yung Hyun
authors: YH
authors: Choi
authors: Gon Sup
authors: GS
authors: Kim
authors: JinMyung
authors: J
authors: Jung
authors: Chung Ho
authors: CH
authors: Ryu
authors: Sung Chul
authors: SC
authors: Shin
authors: Soon Chan
authors: SC
authors: Hong
authors: Hye Jung
authors: HJ
authors: Kim
mesh_terms: D015703:Antigens, CD / Q000378:metabolism*; D000970:Antineoplastic Agents / Q000494:pharmacology; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000378:metabolism; D015820:Cadherins / Q000378:metabolism*; D002448:Cell Adhesion / Q000187:drug effects*; D002460:Cell Line; D045744:Cell Line, Tumor; D015536:Down-Regulation / Q000187:drug effects*; D058750:Epithelial-Mesenchymal Transition / Q000187:drug effects; D005260:Female; D005419:Flavonoids / Q000494:pharmacology*; D061307:Human Umbilical Vein Endothelial Cells / Q000187:drug effects / Q000378:metabolism; D006801:Humans; D029586:Moraceae / Q000737:chemistry; D019010:Vascular Cell Adhesion Molecule-1 / Q000378:metabolism*; D047309:Flavones
chemical_list: D015703:Antigens, CD; D000970:Antineoplastic Agents; D015820:Cadherins; D005419:Flavonoids; D019010:Vascular Cell Adhesion Molecule-1; C050361:CDH2 protein, human; C008548:morin; D047309:Flavones