title: Development of a Functional Biohybrid Implant Formed from Periodontal Tissue Utilizing Bioengineering Technology.
abstract: Current osseointegrated dental implants have been widely used for the rehabilitation of tooth loss. Although dental implants are considered an available treatment in the paradigm shift from traditional dental therapies, such as fixed dental bridges and removable dentures, the fundamental problems must be overcome before their clinical use in young patients who are still undergoing jawbone growth. Here, we show a novel bioengineering method for a functional biohybrid implant that is combined with adult-derived periodontal tissue and attached with bone tissue as a substitute for cementum. This biohybrid implant was successfully engrafted using the bioengineered periodontal ligament, and it restored physiological function, such as orthodontic movement through bone remodeling and appropriate responsiveness to noxious stimuli. Thus, this study represents the functional biohybrid implant's potential for clinical use as a next-generation dental implant using adult-derived tissues.
authors: 1 Department of Clinical Pathophysiology, Tokyo Dental College , Tokyo, Japan .|2 Department of Biological Science and Technology, Graduate School of Industrial Science and Technology, Tokyo University of Science , Noda, Japan .
authors: Kei
authors: K
authors: Nakajima
authors: 3 Research Institute for Science and Technology, Tokyo University of Science , Noda, Japan .|4 Department of Oral and Maxillofacial Rehabilitation, Okayama University Graduate School of Medicine , Dentistry and Pharmaceutical Sciences, Okayama, Japan .
authors: Masamitsu
authors: M
authors: Oshima
authors: 2 Department of Biological Science and Technology, Graduate School of Industrial Science and Technology, Tokyo University of Science , Noda, Japan .|5 Section of Maxillofacial Orthognathics, Department of Maxillofacial Reconstruction and Function, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University , Tokyo, Japan .
authors: Naomi
authors: N
authors: Yamamoto
authors: 2 Department of Biological Science and Technology, Graduate School of Industrial Science and Technology, Tokyo University of Science , Noda, Japan .
authors: Chie
authors: C
authors: Tanaka
authors: 2 Department of Biological Science and Technology, Graduate School of Industrial Science and Technology, Tokyo University of Science , Noda, Japan .
authors: Ryosuke
authors: R
authors: Koitabashi
authors: 1 Department of Clinical Pathophysiology, Tokyo Dental College , Tokyo, Japan .
authors: Takashi
authors: T
authors: Inoue
authors: 2 Department of Biological Science and Technology, Graduate School of Industrial Science and Technology, Tokyo University of Science , Noda, Japan .|6 Laboratory for Organ Regeneration, RIKEN Center for Developmental Biology , Kobe, Japan .|7 Organ Technologies, Inc. , Tokyo, Japan .
authors: Takashi
authors: T
authors: Tsuji
mesh_terms: D000818:Animals; D015921:Dental Implants; D008422:Materials Testing; D051379:Mice; D010519:Periodontium / Q000166:cytology / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D023822:Tissue Engineering
chemical_list: D015921:Dental Implants