title: Exonuclease 1 and its versatile roles in DNA repair.
abstract: Exonuclease 1 (EXO1) is a multifunctional 5' → 3' exonuclease and a DNA structure-specific DNA endonuclease. EXO1 plays roles in DNA replication, DNA mismatch repair (MMR) and DNA double-stranded break repair (DSBR) in lower and higher eukaryotes and contributes to meiosis, immunoglobulin maturation, and micro-mediated end-joining in higher eukaryotes. In human cells, EXO1 is also thought to play a role in telomere maintenance. Mutations in the human EXO1 gene correlate with increased susceptibility to some cancers. This review summarizes recent studies on the enzymatic functions and biological roles of EXO1, its possible protective role against cancer and aging, and regulation of EXO1 by posttranslational modification.
authors: a Department of Cellular and Molecular Medicine , Center for Healthy Aging, University of Copenhagen , Copenhagen , Denmark.
authors: Guido
authors: G
authors: Keijzers
authors: a Department of Cellular and Molecular Medicine , Center for Healthy Aging, University of Copenhagen , Copenhagen , Denmark.
authors: Dekang
authors: D
authors: Liu
authors: a Department of Cellular and Molecular Medicine , Center for Healthy Aging, University of Copenhagen , Copenhagen , Denmark.
authors: Lene Juel
authors: LJ
authors: Rasmussen
mesh_terms: D000375:Aging; D000818:Animals; D053960:DNA Breaks; D004260:DNA Repair; D005090:Exodeoxyribonucleases / Q000032:analysis / Q000235:genetics* / Q000378:metabolism*; D006801:Humans; D008540:Meiosis; D009154:Mutation; D009369:Neoplasms / Q000235:genetics* / Q000378:metabolism; D011499:Protein Processing, Post-Translational
chemical_list: D005090:Exodeoxyribonucleases; C028450:exodeoxyribonuclease I
keywords: Aging; DNA repair; EXO1; cancer; double-strand break repair; mismatch repair; post-translational modification; telomere maintenance