title: Solitary circumscribed neuroma of the palpebral conjunctiva: A rare location.
abstract: OBJECTIVE
  To report a case with solitary circumscribed neuroma (SCN) in the palpebral conjunctiva.
  
  
  METHODS
  This is a retrospective observational case report of a 78-year-old female who showed a yellowish, smooth-surface, dome-shaped mass in the right lower palpebral conjunctiva near the punctum. The mass was completely removed under local anesthesia.
  
  
  RESULTS
  Pathological examination revealed that it was composed of benign spindle-shaped cells and tapering nuclei arranged in bundles. Immunocytochemical analyses for the S100, neurofilament, CD34, and epithelial membrane antigens were all positive. These pathological findings were consistent with a SCN. At the 6-month follow-up, there was no evidence of recurrence.
  
  
  CONCLUSIONS
  This is the first case report of SCN in the palpebral conjunctiva. Although SCN had similar clinicopathological features to other benign peripheral nerve sheath tumors, including neurofibroma and schwannoma, immunocytochemical analyses were helpful for correct diagnosis of this case.
authors: Department of Oculoplastic, Orbital & Lacrimal Surgery, Aichi Medical University Hospital, Nagakute, Aichi, Japan.
authors: Yuichiro
authors: Y
authors: Ishida
authors: Department of Oculoplastic, Orbital & Lacrimal Surgery, Aichi Medical University Hospital, Nagakute, Aichi, Japan.
authors: Yasuhiro
authors: Y
authors: Takahashi
authors: Department of Pathology, Aichi Medical University Hospital, Nagakute, Aichi, Japan.
authors: Emiko
authors: E
authors: Takahashi
authors: Department of Oculoplastic, Orbital & Lacrimal Surgery, Aichi Medical University Hospital, Nagakute, Aichi, Japan. Electronic address: cosme@d1.dion.ne.jp.
authors: Hirohiko
authors: H
authors: Kakizaki
mesh_terms: D000368:Aged; D003230:Conjunctival Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery; D003937:Diagnosis, Differential; D005142:Eyelid Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery; D006801:Humans; D008297:Male; D009463:Neuroma / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery; D035583:Rare Diseases / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery
keywords: Immunocytochemical analysis; Palpebral conjunctiva; Solitary circumscribed neuroma