title: Hollow silica nanospheres coated with insoluble calcium salts for pH-responsive sustained release of anticancer drugs.
abstract: Hollow silica nanospheres coated with biocompatible and pH-sensitive inorganic insoluble calcium salts including calcium carbonate and hydroxyapatite have been successfully prepared. The results indicate that the nanospheres can efficiently load doxorubicin and release it in a pH-responsive and sustained manner, and improve the treatment efficacy significantly.
authors: Collaborative Innovation Center of Henan Province for Green Manufacturing of Fine Chemicals, Key Laboratory of Green Chemical Media and Reactions, Ministry of Education, Henan Normal University, Xinxiang, Henan 453007, P. R. China. guoyuming@htu.edu.cn yanglin1819@163.com and Henan Key Laboratory of Green Chemical Media and Reactions, School of Chemistry and Chemical Engineering, Henan Normal University, Xinxiang, Henan 453007, P. R. China.
authors: Yuming
authors: Y
authors: Guo
authors: Collaborative Innovation Center of Henan Province for Green Manufacturing of Fine Chemicals, Key Laboratory of Green Chemical Media and Reactions, Ministry of Education, Henan Normal University, Xinxiang, Henan 453007, P. R. China. guoyuming@htu.edu.cn yanglin1819@163.com.
authors: Qilong
authors: Q
authors: Fang
authors: Collaborative Innovation Center of Henan Province for Green Manufacturing of Fine Chemicals, Key Laboratory of Green Chemical Media and Reactions, Ministry of Education, Henan Normal University, Xinxiang, Henan 453007, P. R. China. guoyuming@htu.edu.cn yanglin1819@163.com.
authors: Han
authors: H
authors: Li
authors: Collaborative Innovation Center of Henan Province for Green Manufacturing of Fine Chemicals, Key Laboratory of Green Chemical Media and Reactions, Ministry of Education, Henan Normal University, Xinxiang, Henan 453007, P. R. China. guoyuming@htu.edu.cn yanglin1819@163.com.
authors: Weike
authors: W
authors: Shi
authors: Collaborative Innovation Center of Henan Province for Green Manufacturing of Fine Chemicals, Key Laboratory of Green Chemical Media and Reactions, Ministry of Education, Henan Normal University, Xinxiang, Henan 453007, P. R. China. guoyuming@htu.edu.cn yanglin1819@163.com.
authors: Jie
authors: J
authors: Zhang
authors: Collaborative Innovation Center of Henan Province for Green Manufacturing of Fine Chemicals, Key Laboratory of Green Chemical Media and Reactions, Ministry of Education, Henan Normal University, Xinxiang, Henan 453007, P. R. China. guoyuming@htu.edu.cn yanglin1819@163.com.
authors: Jing
authors: J
authors: Feng
authors: Collaborative Innovation Center of Henan Province for Green Manufacturing of Fine Chemicals, Key Laboratory of Green Chemical Media and Reactions, Ministry of Education, Henan Normal University, Xinxiang, Henan 453007, P. R. China. guoyuming@htu.edu.cn yanglin1819@163.com.
authors: Weili
authors: W
authors: Jia
authors: Collaborative Innovation Center of Henan Province for Green Manufacturing of Fine Chemicals, Key Laboratory of Green Chemical Media and Reactions, Ministry of Education, Henan Normal University, Xinxiang, Henan 453007, P. R. China. guoyuming@htu.edu.cn yanglin1819@163.com and Henan Key Laboratory of Green Chemical Media and Reactions, School of Chemistry and Chemical Engineering, Henan Normal University, Xinxiang, Henan 453007, P. R. China.
authors: Lin
authors: L
authors: Yang
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000494:pharmacology; D002118:Calcium / Q000737:chemistry*; D003692:Delayed-Action Preparations / Q000737:chemistry*; D004317:Doxorubicin / Q000008:administration & dosage* / Q000494:pharmacology; D056945:Hep G2 Cells; D006801:Humans; D006863:Hydrogen-Ion Concentration; D054118:Nanospheres / Q000737:chemistry* / Q000648:ultrastructure; D009369:Neoplasms / Q000188:drug therapy; D012492:Salts / Q000737:chemistry; D012822:Silicon Dioxide / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D003692:Delayed-Action Preparations; D012492:Salts; D012822:Silicon Dioxide; D004317:Doxorubicin; D002118:Calcium