title: PTEN expression is a prognostic marker for patients with non-small cell lung cancer: a systematic review and meta-analysis of the literature.
abstract: Phosphatase and tensin homolog deleted on chromosome 10 (PTEN) is a known tumor suppressor in non-small cell lung cancer (NSCLC). By performing a systematic review and meta-analysis of the literature, we determined the prognostic value of decreased PTEN expression in patients with NSCLC. We comprehensively and systematically searched through multiple online databases up to May 22, 2016 for NSCLC studies reporting on PTEN expression and patient survival outcome. Several criteria, including the Newcastle-Ottawa Quality Assessment Scale (NOS), were used to discriminate between studies. In total, 23 eligible studies with a total of 2,505 NSCLC patients were included in our meta-analysis. Our results demonstrated that decreased expression of PTEN correlated with poor overall survival in NSCLC patients and was indicative of a poor prognosis for disease-free survival and progression-free survival in patients with NSCLC.
authors: Department of Geriatrics, Respiratory Medicine, Xiangya Hospital of Central South University, Changsha 410008, China.
authors: Jian
authors: J
authors: Xiao
authors: Department of Respiratory Medicine, Xiangya Hospital of Central South University, Changsha 410008, China.
authors: Cheng-Ping
authors: CP
authors: Hu
authors: Department of Geriatrics, Respiratory Medicine, Xiangya Hospital of Central South University, Changsha 410008, China.
authors: Bi-Xiu
authors: BX
authors: He
authors: Department of Respiratory Medicine, Xiangya Hospital of Central South University, Changsha 410008, China.
authors: Xi
authors: X
authors: Chen
authors: Department of Geriatrics, Respiratory Medicine, Xiangya Hospital of Central South University, Changsha 410008, China.
authors: Xiao-Xiao
authors: XX
authors: Lu
authors: Department of Geriatrics, Respiratory Medicine, Xiangya Hospital of Central South University, Changsha 410008, China.
authors: Ming-Xuan
authors: MX
authors: Xie
authors: Department of Geriatrics, Respiratory Medicine, Xiangya Hospital of Central South University, Changsha 410008, China.
authors: Wei
authors: W
authors: Li
authors: Department of Biochemistry and Biology, University of South China, Hengyang 421001, China.
authors: Shu-Ya
authors: SY
authors: He
authors: Laboratory of Cancer Experimental Therapy, Atlanta Research and Educational Foundation (151F), Atlanta VA Medical Center, Decatur, GA 30033, USA.
authors: Shao-Jin
authors: SJ
authors: You
authors: Department of Geriatrics, Respiratory Medicine, Xiangya Hospital of Central South University, Changsha 410008, China.
authors: Qiong
authors: Q
authors: Chen
mesh_terms: D014408:Biomarkers, Tumor / Q000032:analysis; D002289:Carcinoma, Non-Small-Cell Lung / Q000175:diagnosis / Q000235:genetics / Q000378:metabolism*; D018572:Disease-Free Survival; D006801:Humans; D008175:Lung Neoplasms / Q000175:diagnosis / Q000235:genetics / Q000378:metabolism*; D015999:Multivariate Analysis; D051059:PTEN Phosphohydrolase / Q000235:genetics* / Q000378:metabolism*; D011379:Prognosis; D016896:Treatment Outcome
chemical_list: D014408:Biomarkers, Tumor; D051059:PTEN Phosphohydrolase; C494929:PTEN protein, human
keywords: DFS; NSCLC; PTEN; disease free survival; non-small cell lung cancer