title: Clinical assessment of rosacea severity: oriental score vs. quantitative assessment method with imaging and biomedical tools.
abstract: BACKGROUND
  Rosacea is a common chronic inflammatory disorder affecting facial skin. Currently, no accurate and objective method is available for assessing the severity of rosacea. Most studies use the National Rosacea Society Standard (NRSS) grading method, which lacks objectivity and yields varying results.
  
  
  METHODS
  Eighteen patients with rosacea were included. Clinical severity was assessed on the basis of the NRSS grade, Investigators' Global Assessment, Patients' Global Assessment, and Dermatology Quality of Life Index. A skin color analysis system was used to measure the facial area showing erythema, and biophysical parameters of facial skin (transepidermal water loss and skin surface hydration) were examined. To find statistical significant in classification severity of the rosacea, statistical analysis was performed with all parameters.
  
  
  RESULTS
  A significant correlation (P < 0.05) was found between the NRSS grade, facial area showing erythema, and biophysical parameters. The latter two factors differed significantly among patients with rosacea of different levels of severity (mild, moderate, severe; P < 0.05).
  
  
  CONCLUSIONS
  Color imaging systems can be useful and reliable for evaluating the severity of rosacea, in addition to biophysical parameter assessment. The combination of these two analytical methods enabled objective and quantitative evaluation of the severity of rosacea.
authors: Research Institute for Skin Imaging, Korea University Medical School, Seoul, Korea.
authors: J
authors: J
authors: Kim
authors: Research Institute for Skin Imaging, Korea University Medical School, Seoul, Korea.
authors: J W
authors: JW
authors: Ahn
authors: Department of Nursing, School of Health, Chungbuk Health and Science University, Chungbuk, Korea.
authors: S
authors: S
authors: Ha
authors: Department of Dermatology, Korea University Medical School, Seoul, Korea.
authors: S H
authors: SH
authors: Kwon
authors: Department of Medical IT Engineering, College of Medical Sciences, Soonchunhyang University, Chungnam, Korea.
authors: O
authors: O
authors: Lee
authors: Research Institute for Skin Imaging, Korea University Medical School, Seoul, Korea.|Department of Dermatology, Korea University Medical School, Seoul, Korea.
authors: C
authors: C
authors: Oh
mesh_terms: D003124:Colorimetry / Q000379:methods*; D046169:Dermoscopy / Q000379:methods*; D003936:Diagnosis, Computer-Assisted / Q000379:methods; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015203:Reproducibility of Results; D012393:Rosacea / Q000175:diagnosis* / Q000503:physiopathology*; D012680:Sensitivity and Specificity; D012720:Severity of Illness Index; D012880:Skin Pigmentation; D014870:Water Loss, Insensible
keywords: 
  Helicobacter pylori
  ; Rosacea; barrier function; erythema; severity; skin color analysis; skin surface hydration; transepidermal water loss