title: Porous biomorphic silicon carbide ceramics coated with hydroxyapatite as prospective materials for bone implants.
abstract: Porous and cytocompatible silicon carbide (SiC) ceramics derived from wood precursors and coated with bioactive hydroxyapatite (HA) and HA-zirconium dioxide (HA/ZrO2) composite are materials with promising application in engineering of bone implants due to their excellent mechanical and structural properties. Biomorphic SiC ceramics have been synthesized from wood (Hornbeam, Sapele, Tilia and Pear) using a forced impregnation method. The SiC ceramics have been coated with bioactive HA and HA/ZrO2 using effective gas detonation deposition approach (GDD). The surface morphology and cytotoxicity of SiC ceramics as well as phase composition and crystallinity of deposited coatings were analyzed. It has been shown that the porosity and pore size of SiC ceramics depend on initial wood source. The XRD and FTIR studies revealed the preservation of crystal structure and phase composition of in the HA coating, while addition of ZrO2 to the initial HA powder resulted in significant decomposition of the final HA/ZrO2 coating and formation of other calcium phosphate phases. In turn, NIH 3T3 cells cultured in medium exposed to coated and uncoated SiC ceramics showed high re-cultivation efficiency as well as metabolic activity. The recultivation efficiency of cells was the highest for HA-coated ceramics, whereas HA/ZrO2 coating improved the recultivation efficiency of cells as compared to uncoated SiC ceramics. The GDD method allowed generating homogeneous HA coatings with no change in calcium to phosphorus ratio. In summary, porous and cytocompatible bio-SiC ceramics with bioactive coatings show a great promise in construction of light, robust, inexpensive and patient-specific bone implants for clinical application.
authors: Institute for Multiphase Processes, Leibniz Universität Hannover, 30167 Hannover, Germany. Electronic address: gryshkov@imp.uni-hannover.de.
authors: Oleksandr
authors: O
authors: Gryshkov
authors: College of Physics, Jilin University, 130012 Changchun, PR China; V. Lashkaryov Institute of Semiconductor Physics, National Academy of Science of Ukraine, 03028 Kyiv, Ukraine. Electronic address: klyuini@ukr.net.
authors: Nickolai I
authors: NI
authors: Klyui
authors: V. Lashkaryov Institute of Semiconductor Physics, National Academy of Science of Ukraine, 03028 Kyiv, Ukraine. Electronic address: tvp@isp.kiev.ua.
authors: Volodymyr P
authors: VP
authors: Temchenko
authors: V. Lashkaryov Institute of Semiconductor Physics, National Academy of Science of Ukraine, 03028 Kyiv, Ukraine. Electronic address: kyselov@isp.kiev.ua.
authors: Vitalii S
authors: VS
authors: Kyselov
authors: Institute for Multiphase Processes, Leibniz Universität Hannover, 30167 Hannover, Germany. Electronic address: chatterjee@imp.uni-hannover.de.
authors: Anamika
authors: A
authors: Chatterjee
authors: V. Lashkaryov Institute of Semiconductor Physics, National Academy of Science of Ukraine, 03028 Kyiv, Ukraine. Electronic address: belyaev@isp.kiev.ua.
authors: Alexander E
authors: AE
authors: Belyaev
authors: Institute for Multiphase Processes, Leibniz Universität Hannover, 30167 Hannover, Germany. Electronic address: lauterboeck@imp.uni-hannover.de.
authors: Lothar
authors: L
authors: Lauterboeck
authors: V. Lashkaryov Institute of Semiconductor Physics, National Academy of Science of Ukraine, 03028 Kyiv, Ukraine. Electronic address: iarmolenko.dmytro@isp.kiev.ua.
authors: Dmytro
authors: D
authors: Iarmolenko
authors: Institute for Multiphase Processes, Leibniz Universität Hannover, 30167 Hannover, Germany. Electronic address: glasmacher@imp.uni-hannover.de.
authors: Birgit
authors: B
authors: Glasmacher
mesh_terms: D000818:Animals; D018786:Bone Substitutes / Q000737:chemistry / Q000494:pharmacology; D002516:Ceramics / Q000737:chemistry / Q000494:pharmacology; D020099:Coated Materials, Biocompatible / Q000737:chemistry / Q000494:pharmacology; D017886:Durapatite / Q000737:chemistry / Q000494:pharmacology; D020007:Implants, Experimental; D008422:Materials Testing; D051379:Mice; D041681:NIH 3T3 Cells; D012828:Silicones / Q000737:chemistry / Q000494:pharmacology; D015040:Zirconium / Q000737:chemistry / Q000494:pharmacology
chemical_list: D018786:Bone Substitutes; D020099:Coated Materials, Biocompatible; D012828:Silicones; D017886:Durapatite; D015040:Zirconium; C028541:zirconium oxide
keywords: Biomorphic SiC ceramics; Bone implant; Ceramic coating; Cytocompatibility; Gas detonation deposition; Hydroxyapatite; Morphology; Phase composition; Porosity; Structure