title: Changing the Adverse Event Profile in Metastatic Spine Surgery: An Evidence-Based Approach to Target Wound Complications and Instrumentation Failure.
abstract: METHODS
  Systematic review.
  
  
  OBJECTIVE
  To identify risk factors and preventive methods for wound complications and instrumentation failure after metastatic spine surgery.
  
  
  BACKGROUND
  We focused on two postoperative complications of metastatic spine tumor surgery: wound complications and instrumentation failure and preventive measures.
  
  
  METHODS
  We performed a systematic review of the literature from 1980 to 2015. The articles were analyzed for the presence of documented infection and/or wound complications and instrumentation failure.
  
  
  RESULTS
  Forty articles met our inclusion criteria for wound complications and prevention. There is very low level of evidence that preoperative radiation, preoperative neurological deficit, revision procedures, and posterior approaches can contribute to wound complications (infections, wound dehiscence). There is very low level of evidence that plastic surgery soft tissue reconstruction, intrawound vancomycin powder, and percutaneous pedicle screws may prevent postoperative wound complications. Fourteen articles met our inclusion criteria for instrumentation failure. There is very low level of evidence that constructs greater than six levels, positive sagittal balance, preoperative radiation, and history of chest wall resection can contribute to implant failures.
  
  
  CONCLUSIONS
  • For patients undergoing revision metastatic spine tumor surgery, plastic surgery should perform the soft tissue reconstruction (strong recommendation/very low quality of evidence).• For patients undergoing metastatic spine tumor surgery, plastic surgery may perform immediate soft tissue reconstruction (weak recommendation/very low quality of evidence).• For patients undergoing metastatic spine tumor surgery, intrawound vancomycin can be applied to decrease the risk of postoperative wound infections (weak recommendation/very low quality of evidence).• For patients undergoing metastatic spine tumor surgery, percutaneous pedicle screws can be placed to decrease the risk of postoperative wound complications (weak recommendation/very low quality of evidence).• Instrumentation failure risk factors include constructs greater than six levels, positive sagittal balance, preoperative radiation, and history of chest wall resections (weak recommendation/very low quality of evidence).
  
  
  METHODS
  N/A.
authors: Department of Orthopaedic Surgery, University of Rochester School of Medicine and Dentistry, Rochester, NY.
authors: Addisu
authors: A
authors: Mesfin
authors: Department of Neurosurgery, Johns Hopkins University, Baltimore, MD.
authors: Daniel M
authors: DM
authors: Sciubba
authors: Division of Neurosurgery, University of Sherbrooke, Sherbrooke, Quebec, Canada.
authors: Nicolas
authors: N
authors: Dea
authors: Division of Neurosurgery, University of Toronto, Toronto, Ontario, Canada.
authors: Anick
authors: A
authors: Nater
authors: Department of Orthopaedic Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX.
authors: Justin E
authors: JE
authors: Bird
authors: Centre for Spinal Studies and Surgery, Nothingham University Hospital, Nottingham, UK.
authors: Nasir A
authors: NA
authors: Quraishi
authors: Department of Orthopaedic Surgery, University of British Columbia, Vancouver, BC, Canada.
authors: Charles G
authors: CG
authors: Fisher
authors: Department of Neurosurgery, Massachusetts General Hospital, Boston, MA.
authors: John H
authors: JH
authors: Shin
authors: Division of Neurosurgery, University of Toronto, Toronto, Ontario, Canada.
authors: Michael G
authors: MG
authors: Fehlings
authors: Department of Orthopaedic Surgery, National University Hospital, Singapore.
authors: Naresh
authors: N
authors: Kumar
authors: Department of Neurosurgery, Mayo Clinic, Rochester, MN.
authors: Michelle J
authors: MJ
authors: Clarke
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D006801:Humans; D019637:Orthopedic Procedures / Q000009:adverse effects* / Q000379:methods; D011183:Postoperative Complications / Q000517:prevention & control; D019651:Plastic Surgery Procedures / Q000379:methods; D013125:Spinal Neoplasms / Q000556:secondary / Q000601:surgery*; D013530:Surgical Wound Infection / Q000209:etiology / Q000517:prevention & control*; D016896:Treatment Outcome; D014640:Vancomycin / Q000627:therapeutic use
chemical_list: D000900:Anti-Bacterial Agents; D014640:Vancomycin