title: High Prevalence of Sarcopenia in Korean Patients after Hip Fracture: a Case-Control Study.
abstract: Sarcopenia-related falls and fractures are increasing worldwide due to the aging population. The purpose of this study was to 1) evaluate anthropometric characteristics related to hip fracture in Korean patients, 2) investigate sarcopenia prevalence in hip fracture (HF) and non-hip fracture (NF) groups, and 3) investigate the correlation between sarcopenia and osteoporosis. This case-control study examined 359 HF and 1,614 NF normal populations using Korea National Health and Nutrition Examination Survey data. We performed whole-body dual energy X-ray absorptiometry to analyze body composition using the skeletal muscle mass index (SMI: lean mass/height²) and bone mineral density (BMD). In the HF group, using the AWGS definition, the prevalence of sarcopenia in women and men was 44.3% and 68.2%, respectively; in the NF group, it was 7.1% and 16.1%, respectively. Lower appendicular SMI (P < 0.001), leg muscle mass (P < 0.001), and higher prevalence of sarcopenia (P < 0.001) were observed in the HF group after adjustment for age and gender. In multivariate analysis, sarcopenia (OR = 6.52; 95% CI = 4.67-9.09), age (OR = 1.15; 95% CI = 1.13-1.17), and osteoporosis (OR = 1.87; 95% CI = 1.35-2.58) were associated with the occurrence of a hip fracture. This study showed a higher prevalence of sarcopenia in patients with hip fractures compared with a normal population, and higher prevalence of sarcopenia in men.
authors: Department of Orthopaedic Surgery, Seoul National University Bundang Hospital, Seongnam, Korea.
authors: Jun Il
authors: http://orcid.org/0000-0002-3575-4123
authors: JI
authors: Yoo
authors: Department of Orthopaedic Surgery, Chung-Ang University College of Medicine, Seoul, Korea. hayongch@naver.com.
authors: Yong Chan
authors: http://orcid.org/0000-0002-6249-0581
authors: YC
authors: Ha
authors: Department of Orthopaedic Surgery, Chung-Ang University College of Medicine, Seoul, Korea.
authors: Hyeok Bin
authors: http://orcid.org/0000-0001-5095-4521
authors: HB
authors: Kwon
authors: Department of Orthopaedic Surgery, Seoul National University Bundang Hospital, Seongnam, Korea.
authors: Young Kyun
authors: http://orcid.org/0000-0001-6564-4294
authors: YK
authors: Lee
authors: Department of Orthopaedic Surgery, Seoul National University Bundang Hospital, Seongnam, Korea.
authors: Kyung Hoi
authors: http://orcid.org/0000-0001-5251-2911
authors: KH
authors: Koo
authors: Department of Orthopaedic Surgery, Dankook University College of Medicine, Cheonan, Korea.
authors: Moon Jib
authors: http://orcid.org/0000-0003-2101-1641
authors: MJ
authors: Yoo
mesh_terms: D015502:Absorptiometry, Photon; D000368:Aged; D000369:Aged, 80 and over; D044466:Asian People; D015519:Bone Density; D016022:Case-Control Studies; D005260:Female; D006620:Hip Fractures / Q000150:complications / Q000453:epidemiology*; D006801:Humans; D008297:Male; D018482:Muscle, Skeletal / Q000502:physiology; D009749:Nutrition Surveys; D016017:Odds Ratio; D010024:Osteoporosis / Q000150:complications / Q000453:epidemiology; D015995:Prevalence; D056910:Republic of Korea / Q000453:epidemiology; D055948:Sarcopenia / Q000150:complications / Q000453:epidemiology*; D014807:Vitamin D / Q000031:analogs & derivatives / Q000097:blood; D051598:Whole Body Imaging
chemical_list: D014807:Vitamin D; C104450:25-hydroxyvitamin D
keywords: Dual Energy X-ray Absorptiometry; Hip Fracture; Sarcopenia; Skeletal Muscle Mass