title: [Risk factors for multidrug-resistant tuberculosis in the city of Kinshasa in the Democratic Republic of Congo].
abstract: BACKGROUND
  The aim of this study was to determine the risk factors for multidrug-resistant tuberculosis (TB) in the city of Kinshasa in the Democratic Republic of Congo.
  
  
  METHODS
  This was a case control study. The cases included all TB patients notified as resistant to rifampicin and isoniazid in Kinshasa from January 2012 to June 2013. The controls included TB patients treated during the same period as the cases and declared cured at the end of treatment. For this study, we obtained ethical clearance.
  
  
  RESULTS
  The sample consisted of 213 participants, 132 men (62%) and 81 women (38%). The median age was 31 years (16-73 years). Factors associated with significant (p< 0,05) multidrug-resistant tuberculosis were the non-observance of the hours of taking drugs (0R = 111) (80% cases, 4% controls), the failure of treatment (0R = 20 (76% cases, 13% controls); the concept of multidrug-resistant tuberculosis in the family (0R = 6.4) (28% cases, 6% controls); a lack of knowledge of multidrug-resistant tuberculosis (0R = 3.2) (31% cases, 59% controls); a stay in prison (0R = 7.6) (10% cases, 1% controls) and the interruption of treatment (0R = 6.1) (59% cases, 19% controls).
  
  
  CONCLUSIONS
  The emergence of multidrug-resistant tuberculosis can be avoided by the installation of suitable diagnosis and treatment strategies.
authors: Ministère de la Santé Publique, République Démocratique du Congo.
authors: André
authors: A
authors: Misombo-Kalabela
authors: Université de Yaoundé I, Faculté de Médecine et des Sciences Biomédicales, Yaoundé, Cameroun.
authors: Georges
authors: G
authors: Nguefack-Tsague
authors: Université de Yaoundé I, Faculté de Médecine et des Sciences Biomédicales, Yaoundé, Cameroun.
authors: Ginette Claude Mireille
authors: GC
authors: Kalla
authors: Université de Yaoundé I, Faculté de Médecine et des Sciences Biomédicales, Yaoundé, Cameroun.
authors: Emmanuel Afane
authors: EA
authors: Ze
authors: Université de Kinshasa, Faculté de Médecine, Département de Santé Publique, République Démocratique du Congo.
authors: Kimpanga
authors: K
authors: Diangs
authors: Ministère de la Santé Publique, République Démocratique du Congo.
authors: Tshapenda
authors: T
authors: Panda
authors: Ministère de la Santé Publique, République Démocratique du Congo.
authors: Ilunga
authors: I
authors: Kebela
authors: Ministère de la Santé Publique, République Démocratique du Congo.
authors: Serge Bisuta
authors: SB
authors: Fueza
authors: Ministère de la Santé Publique, République Démocratique du Congo.
authors: Nzanzu
authors: N
authors: Magazani
authors: Université de Yaoundé I, Faculté de Médecine et des Sciences Biomédicales, Yaoundé, Cameroun.
authors: François-Xavier
authors: FX
authors: Mbopi-Kéou
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000995:Antitubercular Agents / Q000008:administration & dosage / Q000494:pharmacology*; D016022:Case-Control Studies; D015023:Democratic Republic of the Congo / Q000453:epidemiology; D005260:Female; D006801:Humans; D007538:Isoniazid / Q000494:pharmacology*; D008297:Male; D008875:Middle Aged; D012293:Rifampin / Q000494:pharmacology*; D012307:Risk Factors; D018088:Tuberculosis, Multidrug-Resistant / Q000188:drug therapy* / Q000453:epidemiology; D055815:Young Adult
chemical_list: D000995:Antitubercular Agents; D007538:Isoniazid; D012293:Rifampin
keywords: Democratic Republic of Congo; Kinshasa; Multidrug-resistant tuberculosis; risk factors