title: Infection with Paracoccidioides brasiliensis induces B-1 cell migration and activation of regulatory T cells.
abstract: Paracoccidioidomycosis is a systemic mycosis endemic to Latin America. The infection is initiated by inhalation of conidia into the lung and may develop as localized or disseminated disease depending on the depression of cellular immunity. In the present study, we observed that intratracheal infection with Paracoccidioides brasiliensis caused the percentage of resident B-1 cells to decrease. Using xid mice reconstituted with B-1 cells, we observed that B-1 cells migrate to the spleen and stimulate increases in the regulatory T cell subpopulation in response to P. brasiliensis infection. Collectively, these data demonstrate an active role for B-1 cells in susceptibility to paracoccidioidomycosis.
authors: Departamento de Análises Clínicas e Toxicológicas, Faculdade de Ciências Farmacêuticas, Universidade de São Paulo, São Paulo, Brazil.
authors: Vanessa
authors: V
authors: Noal
authors: Departamento de Análises Clínicas e Toxicológicas, Faculdade de Ciências Farmacêuticas, Universidade de São Paulo, São Paulo, Brazil.
authors: Suelen
authors: S
authors: Santos
authors: Departamento de Ciências Biológicas, Universidade Federal de São Paulo, São Paulo, Brazil.
authors: Karen Spadari
authors: KS
authors: Ferreira
authors: Departamento de Análises Clínicas e Toxicológicas, Faculdade de Ciências Farmacêuticas, Universidade de São Paulo, São Paulo, Brazil. Electronic address: sandroal@usp.br.
authors: Sandro Rogerio
authors: SR
authors: Almeida
mesh_terms: D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology*; D002465:Cell Movement; D005434:Flow Cytometry; D007843:Latin America; D008168:Lung / Q000276:immunology / Q000473:pathology; D008213:Lymphocyte Activation; D008297:Male; D008807:Mice, Inbred BALB C; D010228:Paracoccidioides / Q000276:immunology*; D010229:Paracoccidioidomycosis / Q000276:immunology / Q000473:pathology*; D013154:Spleen / Q000276:immunology / Q000473:pathology; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*
keywords: B-1 cell; PCM; Regulatory T cell