title: Impact of radiotherapy on implant-based prosthetic rehabilitation in patients with head and neck cancer: A prospective observational study on implant survival and quality of life-Preliminary results.
abstract: OBJECTIVE
  To study implant-based prosthetic rehabilitation of head and neck cancer patients with focus on implant survival and quality of life.
  
  
  METHODS
  The prospective observational study presents preliminary results of 29 edentulous head neck cancer patients (20 patients after radiotherapy) with 165 OsseoSpeed implants. Implant success after 1-year follow-up was evaluated by means of the Albrektsson criteria. Quality of life was analysed with the EORTC QLQ-C30, QLQ-H&N35, and OHIP 14 questionnaires.
  
  
  RESULTS
  The overall implant survival rate after 1 year was 95.2% (157/165). Implant success measured by the Albrektsson criteria showed a lower success rate of 86.7% (143/165), mainly because of peri-implant marginal bone loss with a mean of 0.8 mm after 1 year. Xerostomia (p = 0.008), implant insertion within the radiation target volume (p = 0.09), implantation in transplanted bone (p = 0.05), and smoking (p = 0.041) were the main reasons for implant failure, followed by D4 bone quality, maxillary implant site, and insufficient primary stability. Speaking, swallowing, eating, as well as social integration and individual self-confidence had considerably improved 1 year after denture placement compared to before treatment.
  
  
  CONCLUSIONS
  Implant-based prosthetic rehabilitation of head and neck cancer patients is possible at a calculable risk and significantly improves patients' quality of life.
authors: Department of Oral and Maxillofacial Surgery, University Medical Centre Regensburg (Head: Prof. Dr. Dr. T. Reichert), Franz-Josef-Strauß-Allee 11, 93053 Regensburg, Germany. Electronic address: tobias.ettl@ukr.de.
authors: Tobias
authors: T
authors: Ettl
authors: Department of Oral and Maxillofacial Surgery, University Medical Centre Regensburg (Head: Prof. Dr. Dr. T. Reichert), Franz-Josef-Strauß-Allee 11, 93053 Regensburg, Germany.
authors: Janet
authors: J
authors: Weindler
authors: Department of Oral and Maxillofacial Surgery, Nuremberg Hospital (Head: Prof. Dr. Dr. M. Gosau), Breslauer Straße 201, 90471 Nürnberg, Germany.
authors: Martin
authors: M
authors: Gosau
authors: Department of Oral and Maxillofacial Surgery, University Medical Centre Regensburg (Head: Prof. Dr. Dr. T. Reichert), Franz-Josef-Strauß-Allee 11, 93053 Regensburg, Germany.
authors: Steffen
authors: S
authors: Müller
authors: Department of Radiotherapy, University Medical Centre Regensburg (Head: Prof. Dr. O. Kölbl), Franz-Josef-Strauß-Allee 11, 93053 Regensburg, Germany.
authors: Matthias
authors: M
authors: Hautmann
authors: Centre for Clinical Studies, University Medical Centre Regensburg (Head: Prof. Dr. M. Koller), Franz-Josef-Strauß-Allee 11, 93053 Regensburg, Germany.
authors: Florian
authors: F
authors: Zeman
authors: Centre for Clinical Studies, University Medical Centre Regensburg (Head: Prof. Dr. M. Koller), Franz-Josef-Strauß-Allee 11, 93053 Regensburg, Germany.
authors: Michael
authors: M
authors: Koller
authors: Department of Prosthodontics, University Medical Centre Regensburg (Head: Prof. Dr. G. Handel), Franz-Josef-Strauß-Allee 11, 93053 Regensburg, Germany.
authors: Dimitrios
authors: D
authors: Papavasileiou
authors: Department of Prosthodontics, University Hospital Göttingen (Head: Prof. Dr. R. Bürgers), Robert-Koch-Str. 40, 37075 Göttingen, Germany.
authors: Ralf
authors: R
authors: Bürgers
authors: Department of Oral and Maxillofacial Surgery (Head: Prof. Dr. Dr. B. Frerich), University Medical Centre Rostock, Schillingallee 35, 18057 Rostock, Germany.
authors: Oliver
authors: O
authors: Driemel
authors: Department of Oral and Maxillofacial Surgery, University Medical Centre Regensburg (Head: Prof. Dr. Dr. T. Reichert), Franz-Josef-Strauß-Allee 11, 93053 Regensburg, Germany.
authors: Isabel
authors: I
authors: Schneider
authors: Department of Oral and Maxillofacial Surgery, University Medical Centre Regensburg (Head: Prof. Dr. Dr. T. Reichert), Franz-Josef-Strauß-Allee 11, 93053 Regensburg, Germany.
authors: Christoph
authors: C
authors: Klingelhöffer
authors: Department of Oral and Maxillofacial Surgery, University Medical Centre Regensburg (Head: Prof. Dr. Dr. T. Reichert), Franz-Josef-Strauß-Allee 11, 93053 Regensburg, Germany.
authors: Johannes
authors: J
authors: Meier
authors: Department of Oral and Maxillofacial Surgery, University Medical Centre Regensburg (Head: Prof. Dr. Dr. T. Reichert), Franz-Josef-Strauß-Allee 11, 93053 Regensburg, Germany.
authors: Ulrich
authors: U
authors: Wahlmann
authors: Department of Oral and Maxillofacial Surgery, University Medical Centre Regensburg (Head: Prof. Dr. Dr. T. Reichert), Franz-Josef-Strauß-Allee 11, 93053 Regensburg, Germany.
authors: Torsten E
authors: TE
authors: Reichert
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006258:Head and Neck Neoplasms / Q000532:radiotherapy* / Q000601:surgery; D006801:Humans; D008297:Male; D008875:Middle Aged; D009066:Mouth, Edentulous / Q000534:rehabilitation; D011446:Prospective Studies; D019736:Prostheses and Implants; D011475:Prosthesis Failure; D011788:Quality of Life; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects; D011795:Surveys and Questionnaires; D016896:Treatment Outcome; D014987:Xerostomia / Q000150:complications
keywords: Head and neck cancer; Implant success; Prosthetic rehabilitation; Quality of life; Radiotherapy