title: [The specific features of the distribution of 4-metoxyhydroxybenzene in the organism of the warm-blooded animals suffering lethal intoxication].
abstract: This work was designed to study the distribution of 4-metoxyhydroxybenzene in the organism of the omnivorous warm-blooded animals (rats) after the intragastric administration of this poisonous compound at a dose three-fold greater than the LD50 value. The administered 4-metoxyhydroxybenzene was isolated from the organs and blood of the experimental animals by exposing the biological tissues to acetone with subsequent purification on a silica gel L 40/100 mcm using a hexane:dioxane:propanol-2 (20:5:1) as the mobile phase. The identification and quantitation of 4-metoxyhydroxybenzene were carried out with the use of TLC, GC-MS, and UF-spectrophotometry. It was shown that the administered 4-metoxyhydroxybenzene remained unmetabolized in the internal organs and blood of the poisoned experimental animals. The largest amounts of 4-metoxyhydroxybenzene were found in the stomach contents (2584,92±117,47), brain (59.49±6.05), contents of small intestines (28.21±3.77), and kidneys (26.13±1.64).
authors: Kursk State Medical University, Russian Ministry of Health, Kursk, Russia, 305041.
authors: V K
authors: VK
authors: Shormanov
authors: Tomsk National State Research University, Tomsk, Russia, 634050.
authors: A P
authors: AP
authors: Astashkina
authors: Kursk State Medical University, Russian Ministry of Health, Kursk, Russia, 305041.
authors: M A
authors: MA
authors: Ostanin
authors: Kursk State Medical University, Russian Ministry of Health, Kursk, Russia, 305041.
authors: O I
authors: OI
authors: Grishechko
authors: Kursk State Medical University, Russian Ministry of Health, Kursk, Russia, 305041.
authors: E P
authors: EP
authors: Tsatsua
mesh_terms: D000818:Animals; D005554:Forensic Medicine; D006801:Humans; D019800:Phenol / Q000008:administration & dosage / Q000506:poisoning*; D051381:Rats; D014018:Tissue Distribution / Q000187:drug effects*
chemical_list: D019800:Phenol