title: Heart selenoproteins status of metabolic syndrome-exposed pups: A potential target for attenuating cardiac damage.
abstract: Cardiac hypertrophy is the greatest complication in metabolic syndrome (MS), in dams and in offspring. The most effective therapies to avoid the evolution of MS are anti-oxidants, anti-inflammatories, and insulin sensitizers. Among anti-oxidant elements, Selenium (Se) exerts its functions through selenoproteins, which are essential for the correct functioning of the cardiovascular system. The aim of the study is analyze selenoproteins' implication in the transmission of future cardiovascular problems to MS progeny.
  
  
  
  Heart Se deposits, antioxidant enzymes' activities, biomolecular oxidation, and the expression of selenoproteins, AMPK, and NF-kB were measured in the offspring of dams exposed to a fructose-rich diet (65%) during gestation and lactation, with a normal Se content (0.1 ppm). Thyroid hormones and MCP-1 serum levels, as well as blood pressure and heart rate were also measured. Fructose-exposed pups have cardiomegaly, oxidation, and depletion in Se heart deposits, a decrease in selenoproteins' expression and in the p-AMPK/AMPKt energy ratio; an increase in NF-kB p65 expression, and a decrease of thyroid hormones and MCP-1. Heart rate and blood pressure were altered.
  
  
  
  These data indicate that dietary Se supplementation could be an inexpensive therapy for avoiding future cardiovascular complication in the progeny of MS dams.
authors: Department of Physiology, Faculty of Pharmacy, Seville University, Seville, Spain.
authors: Alejandra
authors: A
authors: Serrano
authors: Department of Physiology, Faculty of Pharmacy, Seville University, Seville, Spain.
authors: Fátima
authors: F
authors: Nogales
authors: Department of Physiology, Faculty of Pharmacy, Seville University, Seville, Spain.
authors: Paula
authors: P
authors: Sobrino
authors: Department of Physiology, Faculty of Pharmacy, Seville University, Seville, Spain.
authors: María Luisa
authors: ML
authors: Murillo
authors: Department of Physiology, Faculty of Pharmacy, Seville University, Seville, Spain.
authors: Olimpia
authors: O
authors: Carreras
authors: Department of Physiology, Faculty of Pharmacy, Seville University, Seville, Spain.
authors: María Luisa
authors: ML
authors: Ojeda
mesh_terms: D055372:AMP-Activated Protein Kinases / Q000235:genetics / Q000378:metabolism; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects; D006332:Cardiomegaly / Q000150:complications / Q000188:drug therapy*; D018932:Chemokine CCL2 / Q000097:blood; D005260:Female; D005632:Fructose / Q000008:administration & dosage / Q000009:adverse effects; D006339:Heart Rate / Q000187:drug effects; D008297:Male; D024821:Metabolic Syndrome / Q000150:complications / Q000188:drug therapy*; D016328:NF-kappa B / Q000235:genetics / Q000378:metabolism; D018384:Oxidative Stress / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D012643:Selenium / Q000097:blood / Q000494:pharmacology; D051140:Selenoproteins / Q000235:genetics / Q000378:metabolism*; D013963:Thyroid Hormones / Q000097:blood
chemical_list: D000975:Antioxidants; D018932:Chemokine CCL2; D016328:NF-kappa B; D051140:Selenoproteins; D013963:Thyroid Hormones; D005632:Fructose; D055372:AMP-Activated Protein Kinases; D012643:Selenium
keywords: Cardiac damage; Fetal programming; High fructose diet; Selenoproteins