title: New challenges in risk assessment of chemicals when simulating real exposure scenarios; simultaneous multi-chemicals' low dose exposure.
abstract: The general population experiences uncontrolled multi-chemicals exposure from many different sources at doses around or well below regulatory limits. Therefore, traditional chronic toxicity evaluations for a single chemical could possibly miss to identify adequately all the risks. For this an experimental methodology that has the ambition to provide at one strike multi-answers to multi-questions is hereby proposed: a long-term toxicity study of non-commercial chemical mixtures, consisting of common everyday life chemicals (pesticides, food additives, life-style products components) at low and realistic dose levels around the regulatory limits and with the simultaneous investigation of several key endpoints, like genotoxicity, endocrine disruption, target organ toxicity including the heart and systemic mechanistic pathways, like oxidative stress.
authors: Department of Forensic Sciences and Toxicology, Faculty of Medicine, University of Crete, Heraklion, 71003, Greece. Electronic address: tsatsaka@med.uoc.gr.
authors: Aristidis M
authors: AM
authors: Tsatsakis
authors: Department of Toxicology, University of Medicine and Pharmacy, Faculty of Pharmacy, Petru Rares, 200349, Craiova, Romania.
authors: Anca Oana
authors: AO
authors: Docea
authors: Department of Hazardous Substances, Mixtures & Article, General Chemical State Laboratory of Greece, 16 An. Tsocha Str., 11521, Ampelokipi, Athens, Greece.
authors: Christina
authors: C
authors: Tsitsimpikou
mesh_terms: D052244:Endocrine Disruptors / Q000032:analysis / Q000633:toxicity*; D004785:Environmental Pollutants / Q000032:analysis / Q000633:toxicity*; D005506:Food Contamination / Q000032:analysis*; D006801:Humans; D010575:Pesticides / Q000032:analysis / Q000633:toxicity*; D018570:Risk Assessment
chemical_list: D052244:Endocrine Disruptors; D004785:Environmental Pollutants; D010575:Pesticides
keywords: ADI; Chemicals; Combined exposure; Long-term toxicity