title: Benzodiazepine dependence in subjects with alcohol use disorders: what prevalence?
abstract: OBJECTIVE
  To our knowledge, no studies have been conducted in France on benzodiazepine (BZD) dependence among outpatients with alcohol use disorders (AUD). Some international studies have been conducted on the consumption of BZD in this specific population, but the comparisons among them are difficult. We aimed to assess the current prevalence of probable benzodiazepine and BZD-like hypnotics (Z-drugs) dependence among outpatients seeking treatment for AUD.
  
  
  METHODS
  Participants were patients seeking treatment for AUD for the first time or repeating treatment after more than twelve months. Recruitment took place in seven addiction centres between January and December 2013 in the Nantes region (France). BZD/Z-drug dependence was assessed according to the DSM-IV diagnostic criteria for dependence. This information was gathered through a self-report questionnaire.
  
  
  RESULTS
  Among the 1005 patients included in this study, 413 were BZD/Z-drug users (41.1%). Among the 413 patients, 217 were probably dependent on at least one substance, which represents 21.6% of the total population and 52.5% of BZD/Z-drug users.
  
  
  CONCLUSIONS
  BZD/Z-drug dependence represents a public health concern. Prescribers should take the risks into account and keep treatment courses to a minimum.
authors: a Center for Evaluation and Information on Pharmacodependence, Department of Clinical Pharmacology , University Hospital , Nantes , France.|b EA4275, Biostatistics, Pharmacoepidemiology and Subjective Measures in Health Sciences , University of Nantes , Nantes , France.
authors: A
authors: A
authors: Morel
authors: b EA4275, Biostatistics, Pharmacoepidemiology and Subjective Measures in Health Sciences , University of Nantes , Nantes , France.|c Addictology and Psychiatry Department , University Hospital , Nantes , France.
authors: M
authors: M
authors: Grall-Bronnec
authors: c Addictology and Psychiatry Department , University Hospital , Nantes , France.
authors: S
authors: S
authors: Bulteau
authors: d Addictology Department , Les Apsyades association , Bouguenais , France.
authors: P
authors: P
authors: Chauvin-Grelier
authors: c Addictology and Psychiatry Department , University Hospital , Nantes , France.|d Addictology Department , Les Apsyades association , Bouguenais , France.
authors: L
authors: L
authors: Gailledrat
authors: a Center for Evaluation and Information on Pharmacodependence, Department of Clinical Pharmacology , University Hospital , Nantes , France.
authors: M L
authors: ML
authors: Pinot
authors: a Center for Evaluation and Information on Pharmacodependence, Department of Clinical Pharmacology , University Hospital , Nantes , France.|b EA4275, Biostatistics, Pharmacoepidemiology and Subjective Measures in Health Sciences , University of Nantes , Nantes , France.
authors: P
authors: P
authors: Jolliet
authors: a Center for Evaluation and Information on Pharmacodependence, Department of Clinical Pharmacology , University Hospital , Nantes , France.|b EA4275, Biostatistics, Pharmacoepidemiology and Subjective Measures in Health Sciences , University of Nantes , Nantes , France.
authors: C
authors: C
authors: Victorri-Vigneau
mesh_terms: D000328:Adult; D019973:Alcohol-Related Disorders / Q000453:epidemiology / Q000534:rehabilitation*; D000553:Ambulatory Care / Q000379:methods; D001569:Benzodiazepines / Q000008:administration & dosage / Q000009:adverse effects*; D003430:Cross-Sectional Studies; D005260:Female; D005602:France / Q000453:epidemiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D016320:Substance Abuse Treatment Centers; D019966:Substance-Related Disorders / Q000453:epidemiology*; D011795:Surveys and Questionnaires
chemical_list: D001569:Benzodiazepines
keywords: Abuse; alcohol; benzodiazepine; dependence; substance use disorder