title: VHLdb: A database of von Hippel-Lindau protein interactors and mutations.
abstract: Mutations in von Hippel-Lindau tumor suppressor protein (pVHL) predispose to develop tumors affecting specific target organs, such as the retina, epididymis, adrenal glands, pancreas and kidneys. Currently, more than 400 pVHL interacting proteins are either described in the literature or predicted in public databases. This data is scattered among several different sources, slowing down the comprehension of pVHL's biological role. Here we present VHLdb, a novel database collecting available interaction and mutation data on pVHL to provide novel integrated annotations. In VHLdb, pVHL interactors are organized according to two annotation levels, manual and automatic. Mutation data are easily accessible and a novel visualization tool has been implemented. A user-friendly feedback function to improve database content through community-driven curation is also provided. VHLdb presently contains 478 interactors, of which 117 have been manually curated, and 1,074 mutations. This makes it the largest available database for pVHL-related information. VHLdb is available from URL: http://vhldb.bio.unipd.it/.
authors: Department of Biomedical Sciences and CRIBI Biotechnology Center, University of Padova, Viale G. Colombo 3, 35121, Padova, Italy.|Institute of Biosciences and Medical Technology, Tampere, Finland.
authors: Francesco
authors: F
authors: Tabaro
authors: Department of Biomedical Sciences and CRIBI Biotechnology Center, University of Padova, Viale G. Colombo 3, 35121, Padova, Italy.
authors: Giovanni
authors: G
authors: Minervini
authors: Department of Biomedical Sciences and CRIBI Biotechnology Center, University of Padova, Viale G. Colombo 3, 35121, Padova, Italy.
authors: Faiza
authors: F
authors: Sundus
authors: Department of Biomedical Sciences and CRIBI Biotechnology Center, University of Padova, Viale G. Colombo 3, 35121, Padova, Italy.
authors: Federica
authors: F
authors: Quaglia
authors: Department of Woman and Child Health, University of Padua, 35131 Padua, Italy.
authors: Emanuela
authors: E
authors: Leonardi
authors: Department of Biomedical Sciences and CRIBI Biotechnology Center, University of Padova, Viale G. Colombo 3, 35121, Padova, Italy.
authors: Damiano
authors: D
authors: Piovesan
authors: Department of Biomedical Sciences and CRIBI Biotechnology Center, University of Padova, Viale G. Colombo 3, 35121, Padova, Italy.|CNR Institute of Neuroscience, Padova, Italy.
authors: Silvio C E
authors: SC
authors: Tosatto
mesh_terms: D016208:Databases, Factual; D006801:Humans; D009154:Mutation; D011485:Protein Binding; D051794:Von Hippel-Lindau Tumor Suppressor Protein / Q000235:genetics / Q000378:metabolism*
chemical_list: D051794:Von Hippel-Lindau Tumor Suppressor Protein; C497446:VHL protein, human