title: Genetic abnormalities associated with the relapse of childhood leukemia.
abstract: Acute leukemia, especially acute lymphoblastic leukemia, is the most common tumor in childhood. Survival in pediatric acute leukemia cases has improved significantly, but once a relapse occurs, the long-term survival rates decrease markedly. Recently, SNP array and next-generation sequencing have revealed the relapse mechanism of pediatric leukemia and genetic alterations which drive leukemia recurrence.
authors: Department of Pathology and Tumor Biology, Graduate School of Medicine, Kyoto University.
authors: Kenichi
authors: K
authors: Yoshida
mesh_terms: D002648:Child; D002872:Chromosome Deletion; D060965:Clonal Evolution; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000235:genetics*; D009154:Mutation; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000235:genetics*; D012008:Recurrence