title: Well, I Wouldn't be Any Worse Off, Would I, Than I am Now? A Qualitative Study of Decision-Making, Hopes, and Realities of Adults With Type 1 Diabetes Undergoing Islet Cell Transplantation.
abstract: BACKGROUND
  For selected individuals with type 1 diabetes, pancreatic islet transplantation (IT) prevents recurrent severe hypoglycemia and optimizes glycemia, although ongoing systemic immunosuppression is needed. Our aim was to explore candidates and recipients' expectations of transplantation, their experience of being on the waiting list, and (for recipients) the procedure and life posttransplant.
  
  
  METHODS
  Cross-sectional qualitative research design using semistructured interviews with 16 adults (8 pretransplant, 8 posttransplant; from 4 UK centers (n = 13) and 1 Canadian center (n = 3)). Interviews were audio-recorded, transcribed, and underwent inductive thematic analysis.
  
  
  RESULTS
  Interviewees were aged (mean ± SD) 52 ± 10 years (range, 30-64); duration of diabetes, 36 ± 9 years (range, 21-56); 12 (75%) were women. Narrative accounts centered on expectations, hopes, and realities; decision-making; waiting and uncertainty; the procedure, hospital stay, and follow-up. Expected benefits included fewer severe hypoglycemic episodes, reduced need for insulin, preventing onset/progression of complications and improved psychological well-being. These were realized for most, at least in the short term. Most interviewees described well-informed, shared decision-making with clinicians and family, and managing their expectations. Although life "on the list" could be stressful, and immunosuppressant side effects were severe, interviewees reported "no regrets." Posttransplant, interviewees experienced increased confidence, through freedom from hypoglycemia and regained glycemic control, which tempered any disappointment about continued reliance on insulin. Most viewed their transplant as a success, though several reflected upon setbacks and hidden hopes for becoming "insulin-free."
  
  
  CONCLUSIONS
  Independently undertaken interviews demonstrated realistic and balanced expectations of IT and indicate how to optimize the process and support for future IT candidates.
authors: AHP Research, Hornchurch, United Kingdom.; The Australian Centre for Behavioural Research in Diabetes, Diabetes Victoria, Melbourne, Australia.; School of Psychology, Deakin University, Burwood, Australia.
authors: Jane
authors: J
authors: Speight
authors: Department of Psychology, Royal Holloway, University of London, Egham, United Kingdom.
authors: Alison J
authors: AJ
authors: Woodcock
authors: AHP Research, Hornchurch, United Kingdom.
authors: Matthew D
authors: MD
authors: Reaney
authors: Diabetes Research Group, King's College London School of Medicine, United Kingdom.
authors: Stephanie A
authors: SA
authors: Amiel
authors: Nuffield Department of Surgery, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom.
authors: Paul
authors: P
authors: Johnson
authors: Renal Transplant Unit, Manchester Royal Infirmary, Manchester, United Kingdom.
authors: Neil
authors: N
authors: Parrott
authors: Manchester Diabetes Centre, Central Manchester University Hospitals, NHS Foundation Trust, Manchester, United Kingdom.; Cardiovascular Medicine Research Group, University of Manchester, Manchester, United Kingdom.
authors: Martin K
authors: MK
authors: Rutter
authors: Division of Endocrinology, University of Alberta, Edmonton, AB, Canada.
authors: Peter
authors: P
authors: Senior
authors: Institute of Cellular Medicine, University of Newcastle, Newcastle, United Kingdom.
authors: James A M
authors: JA
authors: Shaw