title: Extrauterine Placental Site Trophoblastic Tumor Involving the Vagina.
abstract: Very few cases of placental site trophoblastic tumor (PSTT) primarily involving extrauterine sites have been reported to date. We report a case of a 29-year-old female who presented with a vaginal nodule 9 months after delivery at an outside hospital which was initially diagnosed as a poorly differentiated squamous cell carcinoma. Subsequently she was referred to our institute, and on the basis of histology, mildly elevated serum β-HCG level, and immunohistochemistry, PSTT was diagnosed. After the completion of chemotherapy, the vaginal nodule completely regressed and serum β-hCG returned to baseline. Her follow-up has been unremarkable. This case highlights the importance of the fact that PSTT can be easily misdiagnosed at extrauterine sites in the absence of proper clinical, histologic, and immunohistochemical correlation.
authors: Departments of General Pathology (M.G., K.K.G., R.M.)Gynecologic Oncology (A.T., A.S.), Christian Medical College, Vellore, Tamil Nadu, India.
authors: Mayank
authors: M
authors: Gupta
authors: Kiruthiga K
authors: KK
authors: Gnanasekaran
authors: Ramani
authors: R
authors: Manojkumar
authors: Anitha
authors: A
authors: Thomas
authors: Ajit
authors: A
authors: Sebastian
mesh_terms: D000328:Adult; D018997:Chorionic Gonadotropin, beta Subunit, Human / Q000097:blood; D003951:Diagnostic Errors; D005260:Female; D006801:Humans; D007044:Hysterectomy; D007150:Immunohistochemistry; D011247:Pregnancy; D018245:Trophoblastic Tumor, Placental Site / Q000175:diagnosis* / Q000188:drug therapy / Q000378:metabolism / Q000473:pathology; D014594:Uterine Neoplasms / Q000175:diagnosis* / Q000188:drug therapy / Q000378:metabolism / Q000473:pathology; D014621:Vagina / Q000378:metabolism / Q000473:pathology
chemical_list: D018997:Chorionic Gonadotropin, beta Subunit, Human