title: Transversus abdominis plane block or intravenous lignocaine in open prostate surgery: a randomized controlled trial.
abstract: OBJECTIVE
  Transversus abdominis plane block (TAP) and intravenous lignocaine are two analgesic techniques frequently used after abdominal surgery. We hypothesized that these two techniques improve post-operative analgesia after open prostate surgery and sought to compare their efficacy on immediate post-operative outcome after open prostate surgery.
  
  
  METHODS
  After ethics committee approval, 101 patients were enrolled in this prospective study and randomly allocated to receive bilateral ultrasound-guided TAP (n = 34), intravenous lignocaine (n = 33) or placebo (n = 34). In addition, intravenous paracetamol was given every 6 h. The primary endpoint was the cumulative opioid consumption during the first 48 post-operative hours (median[IQR]). Secondary endpoints included pain scores at rest and upon coughing, need for rescue tramadol, incidence of post-operative nausea and vomiting (PONV), recovery of bowel function and incidence of bladder catheter-related discomfort.
  
  
  RESULTS
  Cumulative piritramide consumption after 48 h was 28 [23] mg in the control group, 21 [29] mg in the TAP group and 21 [31] mg in the lignocaine group (P = 0.065). There was no significant difference in post-operative pain scores between groups. The proportions of patients requiring rescue tramadol, experiencing PONV or bladder catheter-related discomfort were similar in each group. Recovery of bowel function was also similar in the three groups.
  
  
  CONCLUSIONS
  Our study suggests that TAP block and intravenous lignocaine do not improve the post-operative analgesia provided by systematic administration of paracetamol after open prostatectomy.
authors: Department of Anaesthesia and Intensive Care Medicine, CHU of Liege, University of Liege, Liege, Belgium. i.maquoi@gmail.com.
authors: I
authors: I
authors: Maquoi
authors: Department of Anaesthesia and Intensive Care Medicine, CHU of Liege, University of Liege, Liege, Belgium.
authors: J L
authors: JL
authors: Joris
authors: Department of Anaesthesia and Intensive Care Medicine, CHR de la Citadelle, Liege, Belgium.
authors: C
authors: C
authors: Dresse
authors: Department of Anaesthesia and Intensive Care Medicine, CHU of Liege, University of Liege, Liege, Belgium.
authors: S
authors: S
authors: Vandenbosch
authors: Department of Anaesthesia and Intensive Care Medicine, CHU of Liege, University of Liege, Liege, Belgium.
authors: I
authors: I
authors: Venneman
authors: Department of Anaesthesia and Intensive Care Medicine, CHU of Liege, University of Liege, Liege, Belgium.
authors: J-F
authors: JF
authors: Brichant
authors: Department of Anaesthesia and Intensive Care Medicine, CHU of Liege, University of Liege, Liege, Belgium.
authors: G A
authors: GA
authors: Hans
mesh_terms: D000368:Aged; D000779:Anesthetics, Local / Q000008:administration & dosage*; D006801:Humans; D008012:Lidocaine / Q000008:administration & dosage*; D008297:Male; D008875:Middle Aged; D009407:Nerve Block / Q000379:methods*; D010149:Postoperative Pain / Q000517:prevention & control*; D011467:Prostate / Q000601:surgery*; D018084:Ultrasonography, Interventional
chemical_list: D000779:Anesthetics, Local; D008012:Lidocaine