title: Chemical Constituents Isolated from Bletilla striata and Their Inhibitory Effects on Nitric Oxide Production in RAW 264.7 Cells.
abstract: Bioassay-guided fractionation of the MeOH extract of the tubers of Bletilla striata led to the isolation of two new C-methylated flavan-3-ols, bletillanols A (1) and B (2), along with ten known compounds (3 - 12). Their structures were determined by using extensive spectroscopic analysis including 1D-, 2D-NMR, and circular dichroism data. All of the isolated compounds were tested for their inhibitory potential on the nitric oxide generation in LPS-stimulated RAW 264.7 cells.
authors: College of Pharmacy, Chungbuk National University, Cheongju, 28644, Korea.
authors: Joon Young
authors: JY
authors: Bae
authors: College of Pharmacy, Chungbuk National University, Cheongju, 28644, Korea.
authors: Jin Woo
authors: JW
authors: Lee
authors: College of Pharmacy, Chungbuk National University, Cheongju, 28644, Korea.
authors: Qinghao
authors: Q
authors: Jin
authors: College of Pharmacy, Chungbuk National University, Cheongju, 28644, Korea.
authors: Hari
authors: H
authors: Jang
authors: College of Life Sciences and Biotechnology, Korea University, Seoul, 02841, Korea.
authors: Dongho
authors: D
authors: Lee
authors: College of Pharmacy, Chungbuk National University, Cheongju, 28644, Korea.
authors: Youngsoo
authors: Y
authors: Kim
authors: College of Pharmacy, Chungbuk National University, Cheongju, 28644, Korea.
authors: Jin Tae
authors: JT
authors: Hong
authors: College of Pharmacy, Chungbuk National University, Cheongju, 28644, Korea.
authors: Mi Kyeong
authors: MK
authors: Lee
authors: College of Agriculture, Life and Environmental Sciences, Chungbuk National University, Cheongju, 28644, Korea.
authors: Moon Soon
authors: MS
authors: Lee
authors: College of Pharmacy, Chungbuk National University, Cheongju, 28644, Korea.
authors: Bang Yeon
authors: BY
authors: Hwang
mesh_terms: D000818:Animals; D008070:Lipopolysaccharides / Q000494:pharmacology; D008264:Macrophages / Q000166:cytology* / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D015394:Molecular Structure; D009569:Nitric Oxide / Q000378:metabolism*; D029595:Orchidaceae / Q000737:chemistry*; D010936:Plant Extracts / Q000494:pharmacology*; D035281:Plant Tubers / Q000737:chemistry*; D000067996:RAW 264.7 Cells
chemical_list: D008070:Lipopolysaccharides; D010936:Plant Extracts; D009569:Nitric Oxide
keywords: 
  Bletilla striata
  ; Bletillanol A; Bletillanol B; Flavan-3-ol; Nitric oxide production; Orchidaceae