title: Unplanned pregnancy on a direct oral anticoagulant (Rivaroxaban): A warning.
abstract: Direct oral anticoagulants (DOACs or NOACs -non-vitamin K oral anticoagulants), as the name suggests, are oral anticoagulants with a direct inhibitory action either against factor X or factor II (thrombin). Pregnant women were excluded from participating in all the large trials of the DOACs and they are considered contra-indicated in pregnancy and breast feeding. We present a case of inadvertent exposure to rivaroxaban in a woman who presented at 25 weeks' gestation. The management of her pregnancy and delivery is described, and the previous published case reports are reviewed with a discussion about the use of DOACs in woman of childbearing age.
authors: Department of Haematology, Leicester Royal Infirmary, Leicester, UK; Lincoln County Hospital, Lincoln, UK.
authors: B
authors: B
authors: Myers
authors: UEA Medical School, Norwich, UK.
authors: R
authors: R
authors: Neal
authors: Department of Haematology, Leicester Royal Infirmary, Leicester, UK.
authors: O
authors: O
authors: Myers
authors: Department of Haematology, Leicester Royal Infirmary, Leicester, UK.
authors: M
authors: M
authors: Ruparelia
keywords: Anticoagulants; Rivaroxaban; direct oral anticoagulants; heavy menstrual bleeding; pregnancy