title: Testicular Signet-Ring Cell Metastasis from a Carcinoma of Unknown Primary Site: A Case Report and Literature Review.
abstract: Signet-ring cell carcinoma is a highly malignant adenocarcinoma consisting of cells characterized as cytoplasmic vacuoles filled with mucin. The most common primary location of this type of cancer is the stomach, but it may also be found in other organs such as prostate, testis, bladder, ovaries, or colon. To date, metastatic signet-ring cell carcinoma of unknown primary (CUP) site to the testis is an extremely rare entity in daily practice. Reviewing the literature, we have been able to detect only three cases of testicular metastases from CUP, two with histological diagnosis of a signet-ring cell carcinoma and one with an adenocarcinoma. In this short paper, we report a case of a 56-year-old man who presented to our Department with testicular mass and ascites. Following a standard diagnostic approach no primary tumor could be identified. CUP was the final clinical diagnosis, histologically characterized as poorly differentiated adenocarcinoma with signet-ring cells involving the peritoneum and the testicular structures.
authors: Department of Medical Oncology, University Hospital of Ioannina, 45500 Ioannina, Greece.
authors: Aristomenes
authors: A
authors: Kollas
authors: Department of Medical Oncology, University Hospital of Ioannina, 45500 Ioannina, Greece.
authors: George
authors: G
authors: Zarkavelis
authors: Department of Pathology, University Hospital of Ioannina, 45500 Ioannina, Greece.
authors: Anna
authors: A
authors: Goussia
authors: Department of Medical Oncology, University Hospital of Ioannina, 45500 Ioannina, Greece.
authors: Aikaterini
authors: A
authors: Kafantari
authors: Department of Pathology, University Hospital of Ioannina, 45500 Ioannina, Greece.
authors: Anna
authors: A
authors: Batistatou
authors: Department of Pathology, University Hospital of Ioannina, 45500 Ioannina, Greece.
authors: Zoi
authors: 0000-0001-5240-0127
authors: Z
authors: Evangelou
authors: Department of Cytology, University Hospital of Ioannina, 45500 Ioannina, Greece.
authors: Eva
authors: E
authors: Sintou
authors: Department of Medical Oncology, University Hospital of Ioannina, 45500 Ioannina, Greece.
authors: Nicholas
authors: 0000-0002-2195-9961
authors: N
authors: Pavlidis