title: rs1495741 as a tag single nucleotide polymorphism of N-acetyltransferase 2 acetylator phenotype associates bladder cancer risk and interacts with smoking: A systematic review and meta-analysis.
abstract: Rs1495741 has been identified to infer N-acetyltransferase 2 (NAT2) acetylator phenotype, and to decrease the risk of bladder cancer. However, a number of studies conducted in various regions showed controversial results. To quantify the association between rs1495741 and the risk of bladder cancer and to estimate the interaction effect of this genetic variant with smoking, we performed a systematic literature review and meta-analysis involving 14,815 cases and 58,282 controls from 29 studies. Our results indicates rs1495741 significantly associated with bladder cancer risk (OR = 0.85, 95% CI = 0.82-0.89, test for heterogeneity P = 0.36, I = 7.0%). And we verified this association in populations from Europe, America, and Asia. Further, our stratified meta-analysis showed rs1495741's role is typically evident only in ever smokers, which suggests its interaction with smoking. This study may provide new insight into gene-environment study on bladder cancer.
authors: Department of Urology Department of Nursing Department of Spine Surgery, Changhai Hospital, Second Military Medical University, Shanghai, China.
authors: Chong
authors: C
authors: Ma
authors: Liyan
authors: L
authors: Gu
authors: Mingyuan
authors: M
authors: Yang
authors: Zhensheng
authors: Z
authors: Zhang
authors: Shuxiong
authors: S
authors: Zeng
authors: Ruixiang
authors: R
authors: Song
authors: Chuanliang
authors: C
authors: Xu
authors: Yinghao
authors: Y
authors: Sun
mesh_terms: D001191:Arylamine N-Acetyltransferase / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease / Q000453:epidemiology*; D005838:Genotype; D006801:Humans; D008297:Male; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D015995:Prevalence; D011379:Prognosis; D018570:Risk Assessment; D012907:Smoking / Q000009:adverse effects / Q000453:epidemiology*; D001749:Urinary Bladder Neoplasms / Q000453:epidemiology / Q000235:genetics* / Q000473:pathology
chemical_list: D001191:Arylamine N-Acetyltransferase; C478900:NAT2 protein, human