title: Experimental Evaluation of Biodegradable Film Compositions Based on Gelatin with Colchicine.
abstract: Biodegradable film compositions based on natural biopolymer gelatin with immobilized colchicine were prepared and their efficiency in prevention of the adhesion process in the pericardium was evaluated on rabbit model of postoperative pericarditis. The use of gelatin-based biodegradable film compositions significantly reduced the intensity of adhesion formation in the pericardial cavity, while immobilization of anti-inflammatory drug colchicine amplified their anti-adhesion activity.
authors: A.N. Bakoulev Scientific Center for Cardiovascular Surgery, Moscow, Russia.
authors: L A
authors: LA
authors: Bokeriya
authors: A.N. Bakoulev Scientific Center for Cardiovascular Surgery, Moscow, Russia.
authors: O L
authors: OL
authors: Bokeriya
authors: A.N. Bakoulev Scientific Center for Cardiovascular Surgery, Moscow, Russia.
authors: V S
authors: VS
authors: Sivtsev
authors: A.N. Bakoulev Scientific Center for Cardiovascular Surgery, Moscow, Russia. spnovikova@bakulev.ru.
authors: S P
authors: SP
authors: Novikova
authors: A.N. Bakoulev Scientific Center for Cardiovascular Surgery, Moscow, Russia.
authors: R R
authors: RR
authors: Salokhedinova
authors: A.N. Bakoulev Scientific Center for Cardiovascular Surgery, Moscow, Russia.
authors: L N
authors: LN
authors: Nikolashina
authors: A.N. Bakoulev Scientific Center for Cardiovascular Surgery, Moscow, Russia.
authors: N N
authors: NN
authors: Samsonova
authors: A.N. Bakoulev Scientific Center for Cardiovascular Surgery, Moscow, Russia.
authors: A Yu
authors: AY
authors: Gorodkov
authors: A.N. Bakoulev Scientific Center for Cardiovascular Surgery, Moscow, Russia.
authors: R A
authors: RA
authors: Serov
mesh_terms: D000818:Animals; D001673:Biodegradation, Environmental; D003078:Colchicine / Q000737:chemistry*; D005260:Female; D005780:Gelatin / Q000009:adverse effects / Q000737:chemistry*; D008297:Male; D010496:Pericardium / Q000166:cytology / Q000187:drug effects; D011817:Rabbits
chemical_list: C015233:gelatin film; D005780:Gelatin; D003078:Colchicine
keywords: biodegradable films; colchicine; gelatin; low doses; postoperative pericarditis