title: Effects of two different doses of intravitreal bevacizumab on subfoveal choroidal thickness and retinal vessel diameter in branch retinal vein occlusion.
abstract: OBJECTIVE
  To investigate the effects of two different doses of intravitreal bevacizumab on subfoveal choroidal thickness (SFChT) and retinal vessel diameter in patients with branch retinal vein occlusion.
  
  
  METHODS
  An interventional, restrospective study of 41 eyes of 41 patients who had completed 12mo of follow-up, divided into group 1 (1.25 mg of bevacizumab, 21 eyes of 21 patients) and group 2 (2.5 mg of bevacizumab, 20 eyes of 21 patients). Complete ophthalmic examination, fluorescein angiography, enhanced depth imaging optical coherence tomography and measurement of retinal vessel diameter with IVAN software were performed at baseline and follow-up.
  
  
  RESULTS
  The SFChT changed from 279.1 (165-431) µm at baseline to 277.0 (149-413) µm at 12mo in group 1 (P=0.086), and from 301.4 (212-483) µm to 300.3 (199-514) µm in group 2 (P=0.076). The central retinal arteriolar equivalent (CRAE) changed from 128.8±11.2 µm at baseline to 134.5±8.4 µm at 12mo in group 1, and from 134.6±9.0 µm to 131.4±12.7 µm in group 2 (P=0.767). The central retinal venular equivalent (CRVE) changed from 204.1±24.4 µm at baseline to 196.3±28.2 µm at 12mo in group 1, and from 205.8±16.3 µm to 194.8±18.2 µm in group 2 (P=0.019). The mean central macular thickness (P<0.05) and average best-corrected visual acuity (BCVA; P<0.05) improved in both groups.
  
  
  CONCLUSIONS
  Changes in the SFChT are not statistically significant and not different according to the doses of bevacizumab. The CRAE did not show significant change, however, the CRVE showed significant decrease regardless of the dose.
authors: Department of Ophthalmology, Dongguk University Gyeongju Hospital, Gyeongju-si, Gyeongsangbuk-do 780-350, Korea.
authors: Jongyeop
authors: J
authors: Park
authors: Department of Ophthalmology, Dongguk University Gyeongju Hospital, Gyeongju-si, Gyeongsangbuk-do 780-350, Korea.
authors: Seungwoo
authors: S
authors: Lee
authors: Department of Ophthalmology, Dongguk University Gyeongju Hospital, Gyeongju-si, Gyeongsangbuk-do 780-350, Korea.
authors: Yengwoo
authors: Y
authors: Son
keywords: bevacizumab; choroids tomography; intravitreal injections; optical coherence; retinal vein occlusion; retinal vessels