title: Ebola Virus Disease Is Characterized by Poor Activation and Reduced Levels of Circulating CD16+ Monocytes.
abstract: A number of previous studies have identified antigen-presenting cells (APCs) as key targets of Ebola virus (EBOV), but the role of APCs in human Ebola virus disease (EVD) is not known. We have evaluated the phenotype and kinetics of monocytes, neutrophils, and dendritic cells (DCs) in peripheral blood of patients for whom EVD was diagnosed by the European Mobile Laboratory in Guinea. Acute EVD was characterized by reduced levels of circulating nonclassical CD16+monocytes with a poor activation profile. In survivors, CD16+monocytes were activated during recovery, coincident with viral clearance, suggesting an important role of this cell subset in EVD pathophysiology.
authors: Heinrich Pette Institute, Leibniz Institute for Experimental Virology Department of Virology The European Mobile Laboratory Consortium, Bernhard Nocht Institute for Tropical Medicine, Hamburg German Center for Infection Research, Partner Site Hamburg.
authors: Anja
authors: A
authors: Lüdtke
authors: Heinrich Pette Institute, Leibniz Institute for Experimental Virology Department of Virology The European Mobile Laboratory Consortium, Bernhard Nocht Institute for Tropical Medicine, Hamburg German Center for Infection Research, Partner Site Hamburg.
authors: Paula
authors: P
authors: Ruibal
authors: Department of Virology The European Mobile Laboratory Consortium, Bernhard Nocht Institute for Tropical Medicine, Hamburg German Center for Infection Research, Partner Site Hamburg.
authors: Beate
authors: B
authors: Becker-Ziaja
authors: Heinrich Pette Institute, Leibniz Institute for Experimental Virology.
authors: Monika
authors: M
authors: Rottstegge
authors: Department of Virology The European Mobile Laboratory Consortium, Bernhard Nocht Institute for Tropical Medicine, Hamburg German Center for Infection Research, Partner Site Hamburg.
authors: David M
authors: DM
authors: Wozniak
authors: Department of Virology German Center for Infection Research, Partner Site Hamburg.
authors: Mar
authors: M
authors: Cabeza-Cabrerizo
authors: Hannover Medical School.
authors: Anja
authors: A
authors: Thorenz
authors: Institute of Experimental Virology, Twincore, Center for Experimental and Clinical Infection Research, Hannnover, Germany.
authors: Romy
authors: R
authors: Weller
authors: Department of Virology The European Mobile Laboratory Consortium, Bernhard Nocht Institute for Tropical Medicine, Hamburg German Center for Infection Research, Partner Site Hamburg.
authors: Romy
authors: R
authors: Kerber
authors: Department of Microbiology and Immunology, Stanford University School of Medicine, California.
authors: Juliana
authors: J
authors: Idoyaga
authors: Université Gamal Abdel Nasser de Conakry, Laboratoire des Fièvres Hémorragiques en Guinée, Conakry, Guinea.
authors: N'Faly
authors: N
authors: Magassouba
authors: Department of Virology The European Mobile Laboratory Consortium, Bernhard Nocht Institute for Tropical Medicine, Hamburg German Center for Infection Research, Partner Site Hamburg.
authors: Martin
authors: M
authors: Gabriel
authors: Department of Virology The European Mobile Laboratory Consortium, Bernhard Nocht Institute for Tropical Medicine, Hamburg German Center for Infection Research, Partner Site Hamburg.
authors: Stephan
authors: S
authors: Günther
authors: Department of Virology The European Mobile Laboratory Consortium, Bernhard Nocht Institute for Tropical Medicine, Hamburg German Center for Infection Research, Partner Site Hamburg.
authors: Lisa
authors: L
authors: Oestereich
authors: Heinrich Pette Institute, Leibniz Institute for Experimental Virology Department of Virology The European Mobile Laboratory Consortium, Bernhard Nocht Institute for Tropical Medicine, Hamburg German Center for Infection Research, Partner Site Hamburg.
authors: César
authors: C
authors: Muñoz-Fontela
mesh_terms: D003713:Dendritic Cells / Q000276:immunology* / Q000821:virology; D029043:Ebolavirus / Q000276:immunology* / Q000302:isolation & purification; D005260:Female; D019142:Hemorrhagic Fever, Ebola / Q000175:diagnosis / Q000276:immunology* / Q000503:physiopathology / Q000821:virology; D006801:Humans; D007700:Kinetics; D008952:Mobile Health Units; D009000:Monocytes / Q000276:immunology* / Q000821:virology; D009504:Neutrophils / Q000276:immunology* / Q000821:virology; D010641:Phenotype; D017452:Receptors, IgG / Q000276:immunology*
chemical_list: D017452:Receptors, IgG
keywords: CD14; CD16; Ebola virus; Ebola virus disease; monocytes