title: Cellular Delivery of RNA Nanoparticles.
abstract: RNA nanostructures can be programmed to exhibit defined sizes, shapes and stoichiometries from naturally occurring or de novo designed RNA motifs. These constructs can be used as scaffolds to attach functional moieties, such as ligand binding motifs or gene expression regulators, for nanobiology applications. This review is focused on four areas of importance to RNA nanotechnology: the types of RNAs of particular interest for nanobiology, the assembly of RNA nanoconstructs, the challenges of cellular delivery of RNAs in vivo, and the delivery carriers that aid in the matter. The available strategies for the design of nucleic acid nanostructures, as well as for formulation of their carriers, make RNA nanotechnology an important tool in both basic research and applied biomedical science.
authors: Gene Regulation and Chromosome Biology Laboratory, National Cancer Institute , Frederick, Maryland 21702, United States.
authors: Lorena
authors: L
authors: Parlea
authors: Gene Regulation and Chromosome Biology Laboratory, National Cancer Institute , Frederick, Maryland 21702, United States.
authors: Anu
authors: A
authors: Puri
authors: Basic Science Program, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research , Frederick, Maryland 21702, United States.
authors: Wojciech
authors: W
authors: Kasprzak
authors: Basic Science Program, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research , Frederick, Maryland 21702, United States.
authors: Eckart
authors: E
authors: Bindewald
authors: Gene Regulation and Chromosome Biology Laboratory, National Cancer Institute , Frederick, Maryland 21702, United States.
authors: Paul
authors: P
authors: Zakrevsky
authors: Department of Chemistry, University of North Carolina at Charlotte , Charlotte, North Carolina 28223, United States.
authors: Emily
authors: E
authors: Satterwhite
authors: Department of Chemistry, University of North Carolina at Charlotte , Charlotte, North Carolina 28223, United States.
authors: Kenya
authors: K
authors: Joseph
authors: Department of Chemistry, University of North Carolina at Charlotte , Charlotte, North Carolina 28223, United States.|Nanoscale Science Program, University of North Carolina at Charlotte , Charlotte North Carolina 28223, United States ;|The Center for Biomedical Engineering and Science, University of North Carolina at Charlotte , Charlotte North Carolina 28223, United States.
authors: Kirill A
authors: KA
authors: Afonin
authors: Gene Regulation and Chromosome Biology Laboratory, National Cancer Institute , Frederick, Maryland 21702, United States.
authors: Bruce A
authors: BA
authors: Shapiro
mesh_terms: D000818:Animals; D052157:Aptamers, Nucleotide / Q000737:chemistry; D002626:Chemistry, Pharmaceutical; D019295:Computational Biology; D016503:Drug Delivery Systems / Q000379:methods*; D015195:Drug Design; D065546:Drug Liberation; D015316:Genetic Therapy; D005822:Genetic Vectors; D006801:Humans; D058990:Molecular Targeted Therapy / Q000379:methods; D053758:Nanoparticles / Q000737:chemistry*; D036103:Nanotechnology; D012313:RNA / Q000008:administration & dosage* / Q000737:chemistry* / Q000276:immunology / Q000633:toxicity; D034622:RNA Interference; D012326:RNA Splicing; D013499:Surface Properties
chemical_list: D052157:Aptamers, Nucleotide; D012313:RNA
keywords: RNA; RNA nanoparticle; delivery; nanoconstruct; self-assembly; therapeutics