title: Oral dosage form administration practice in children under 6 years of age: A survey study of paediatric nurses.
abstract: The purpose of this study was to interview paediatric nurses on administration issues using extemporaneous capsules and marketed capsules and tablets in children younger than 6 years old, based on most frequently administered drugs in six participating wards. The 59 responding nurses estimated respectively at 7.7±1.7 and 7.3±1.8years the age from which children would properly swallow extemporaneous capsules and marketed solids, with 33% and 37% of nurses considering that children under 6 would not get their prescribed treatment using these dosage forms. Refusal of the child to take the solid was the first reason to explain administration failure (85% of nurses for extemporaneous capsules, 89% for marketed solids). Although type of formulation and requirement of chewing were factors influencing the age at which children would take solid from nurses' experience, size of conventional tablets was not among these factors. All respondents use to crush tablets in children unable to swallow whole solids; 37% of nurses systematically split the tablets to ease the swallowing in children able to swallow. Only 11 nurses had an information tool at their disposal to guide manipulation of solids, with 7 of them using it in their daily practice. Providing specific-ward questionnaires, this study gives factual information on administration practices, perceptions and issues faced by paediatric nurses.
authors: Clinical Investigation Centre CIC-INSERM 1407, EPICIME, Department of Clinical Pharmacology, Hospices Civils de Lyon, France. Electronic address: ac.walch@gmail.com.
authors: A C
authors: AC
authors: Walch
authors: Clinical Investigation Centre CIC-INSERM 1407, EPICIME, Department of Clinical Pharmacology, Hospices Civils de Lyon, France; UMR CNRS 5558, Laboratoire de Biométrie et Biologie Evolutive LBBE, Equipe Evaluation et Modélisation des Effets Thérapeutiques EMET, University Claude Bernard Lyon 1, France.
authors: E
authors: E
authors: Henin
authors: Clinical Investigation Centre CIC-INSERM 1407, EPICIME, Department of Clinical Pharmacology, Hospices Civils de Lyon, France.
authors: J
authors: J
authors: Berthiller
authors: Department of Pharmacy, Hospices Civils de Lyon, France.
authors: X
authors: X
authors: Dode
authors: Clinical Investigation Centre CIC-INSERM 1407, EPICIME, Department of Clinical Pharmacology, Hospices Civils de Lyon, France.
authors: B
authors: B
authors: Abel
authors: Clinical Investigation Centre CIC-INSERM 1407, EPICIME, Department of Clinical Pharmacology, Hospices Civils de Lyon, France; UMR CNRS 5558, Laboratoire de Biométrie et Biologie Evolutive LBBE, Equipe Evaluation et Modélisation des Effets Thérapeutiques EMET, University Claude Bernard Lyon 1, France.
authors: B
authors: B
authors: Kassai
authors: Clinical Investigation Centre CIC-INSERM 1407, EPICIME, Department of Clinical Pharmacology, Hospices Civils de Lyon, France; UMR CNRS 5558, Laboratoire de Biométrie et Biologie Evolutive LBBE, Equipe Evaluation et Modélisation des Effets Thérapeutiques EMET, University Claude Bernard Lyon 1, France.
authors: A
authors: A
authors: Lajoinie
mesh_terms: D000284:Administration, Oral; D000328:Adult; D000367:Age Factors; D001291:Attitude of Health Personnel; D002214:Capsules; D002675:Child, Preschool; D006801:Humans; D000072222:Nurses, Pediatric / Q000523:psychology*; D011795:Surveys and Questionnaires; D013607:Tablets
chemical_list: D002214:Capsules; D013607:Tablets
keywords: Acceptability; Drug formulation; Formulation appropriateness; Nurses administration practices; Oral drug administration; Paediatric