title: FULL-THICKNESS MACULAR HOLE COMBINED WITH PIGMENT EPITHELIAL DETACHMENT USING MULTIMODAL IMAGING.
abstract: OBJECTIVE
  To describe two patients who showed full-thickness macular holes (FTMH) combined with pigment epithelial detachments (PED) and had contrasting outcomes to treatment.
  
  
  METHODS
  A retrospective report of two cases.
  
  
  RESULTS
  Case 1 was treated with intravitreal antivascular endothelial growth factor and photodynamic therapy, and the PED flattened. Subsequently, a vitrectomy was performed and the FTMH closed. Her visual acuity improved from 20/200 to 20/25. In Case 2, the same medical therapy, with less frequency compared with Case 1, did not affect the PED, and the FTMH failed to close with surgery. Later, a spontaneous collapse of the PED occurred but the FTMH was persistent with an associated poor visual acuity of 20/200.
  
  
  CONCLUSIONS
  Full-thickness macular hole is rare, but can occur in association with large PEDs. Although the pathologic mechanism was uncertain, visual outcomes were dependent on response to treatments of the PED, as well as anatomical closure of the FTMH.
authors: *Vitreous Retina Macula Consultants of New York, New York, New York; †The LuEsther T. Mertz Retinal Research Center, Manhattan Eye, Ear and Throat Hospital, New York, New York; ‡Department of Ophthalmology, Yokohama City University Medical Center, Yokohama, Japan; §Singapore Eye Research Institute, Singapore National Eye Center, Singapore, Singapore; and ¶Department of Ophthalmology, Edward S. Harkness Eye Institute, Columbia University College of Physicians and Surgeons, New York, New York.
authors: Maiko
authors: M
authors: Inoue
authors: Anna
authors: A
authors: Tan
authors: Jason S
authors: JS
authors: Slakter
authors: Stanley
authors: S
authors: Chang
authors: Kazuaki
authors: K
authors: Kadonosono
authors: Lawrence A
authors: LA
authors: Yannuzzi
mesh_terms: D000368:Aged; D020533:Angiogenesis Inhibitors / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008297:Male; D064847:Multimodal Imaging; D010778:Photochemotherapy / Q000379:methods; D012163:Retinal Detachment / Q000628:therapy*; D012167:Retinal Perforations / Q000628:therapy*; D012189:Retrospective Studies; D016896:Treatment Outcome; D014821:Vitrectomy / Q000379:methods
chemical_list: D020533:Angiogenesis Inhibitors