title: Retinal sensitivity after selective retina therapy (SRT) on patients with central serous chorioretinopathy.
abstract: OBJECTIVE
  To assess retinal sensitivity after selective retina therapy (SRT) in patients with central serous chorioretinopathy (CSCR).
  
  
  METHODS
  Seventeen eyes of 17 patients with CSCR lasting longer than 3 months were treated with SRT (wavelength 527 nm Nd: YLF laser, 50-150 μJ/pulse, spot diameter 200 μm). Measurement of best-corrected visual acuity (BCVA), optical coherence tomography, fluorescence angiography, and microperimetry (MAIA™) were conducted before, and 1 and 3 months after treatment. Microperimetry was performed in the central 10° of the macula, and at the test spots applied near the vascular arcade for energy titration. In addition to the treatment effect, all test irradiation spots were thoroughly analyzed with regard to their sensitivity changes.
  
  
  RESULTS
  The mean logMAR BCVA had improved from 0.06 to 0.02 after 1 month (p = 0.11) and to 0.03 after 3 months (p = 0.003). Eleven out of 17 eyes (64.7%) showed complete resolution of subretinal fluid after 3 months. Retinal sensitivity in the central 10° increased after 1 month (median: 25.9 dB) and 3 months (26.6 dB) as compared with that before treatment (23.0 dB) (p < 0.001). Analysis of the test spots revealed a slight decrease in retinal sensitivity after 1 month (ΔdB = -0.5 ± 2.1, p = 0.006), while there was no significant difference from baseline after 3 months (ΔdB = -0.3 ± 2.2, p = 0.09). No correlation was found between laser energy and the change in focal retinal sensitivity.
  
  
  CONCLUSIONS
  Results suggest that SRT is a safe and effective treatment for persistent CSCR and does not leave permanent scotoma regardless of irradiation energy in the therapeutic range.
authors: Department of Ophthalmology and Visual Sciences, Osaka City University Graduate School of Medicine, 1-4-3 Asahi-machi, Abeno-ku, 545-8585, Osaka, Japan.
authors: Ayako
authors: A
authors: Yasui
authors: Department of Ophthalmology and Visual Sciences, Osaka City University Graduate School of Medicine, 1-4-3 Asahi-machi, Abeno-ku, 545-8585, Osaka, Japan. shidai.srtmaia@gmail.com.
authors: Manabu
authors: http://orcid.org/0000-0001-6666-8706
authors: M
authors: Yamamoto
authors: Department of Ophthalmology and Visual Sciences, Osaka City University Graduate School of Medicine, 1-4-3 Asahi-machi, Abeno-ku, 545-8585, Osaka, Japan.
authors: Kumiko
authors: K
authors: Hirayama
authors: Department of Ophthalmology and Visual Sciences, Osaka City University Graduate School of Medicine, 1-4-3 Asahi-machi, Abeno-ku, 545-8585, Osaka, Japan.
authors: Kunihiko
authors: K
authors: Shiraki
authors: Medical Laser Center Lübeck GmbH, Lübeck, Germany.
authors: Dirk
authors: D
authors: Theisen-Kunde
authors: Medical Laser Center Lübeck GmbH, Lübeck, Germany.
authors: Ralf
authors: R
authors: Brinkmann
authors: Medical Laser Center Lübeck GmbH, Lübeck, Germany.|Institute of Biomedical Optics, University of Lübeck, Lübeck, Germany.|Department of Ophthalmology, University of Lübeck, Lübeck, Germany.
authors: Yoko
authors: Y
authors: Miura
authors: Department of Ophthalmology and Visual Sciences, Osaka City University Graduate School of Medicine, 1-4-3 Asahi-machi, Abeno-ku, 545-8585, Osaka, Japan.
authors: Takeya
authors: T
authors: Kohno
mesh_terms: D000328:Adult; D000368:Aged; D056833:Central Serous Chorioretinopathy / Q000175:diagnosis / Q000188:drug therapy* / Q000503:physiopathology; D005260:Female; D005451:Fluorescein Angiography; D005500:Follow-Up Studies; D005654:Fundus Oculi; D006801:Humans; D017075:Laser Coagulation / Q000379:methods*; D008297:Male; D008875:Middle Aged; D010778:Photochemotherapy / Q000379:methods*; D017319:Photosensitizing Agents / Q000627:therapeutic use*; D012160:Retina / Q000473:pathology / Q000503:physiopathology*; D055213:Retinal Pigment Epithelium / Q000473:pathology*; D012189:Retrospective Studies; D058471:Subretinal Fluid / Q000000981:diagnostic imaging; D013997:Time Factors; D041623:Tomography, Optical Coherence; D014792:Visual Acuity; D058609:Visual Field Tests; D014794:Visual Fields / Q000502:physiology*
chemical_list: D017319:Photosensitizing Agents
keywords: Central serous chorioretinopathy; Microperimetry; Retinal pigment epithelium; Retinal sensitivity; Subvisible laser