title: Eudesmane-type sesquiterpenoids from Salvia plebeia inhibit IL-6-induced STAT3 activation.
abstract: Seven eudesmane-type sesquiterpenoid lactones and the known plebeiolide C were isolated from an ethanol-soluble extract of the aerial parts of Salvia plebeia R. Br. Their structures were determined via NMR and MS, and their absolute configurations were elucidated using ECD, and X-ray crystallographic analysis, as well as the modified Mosher ester method. All isolates were evaluated for their inhibitory effects on IL6-induced STAT3 promoter activation in stably transfected Hep3B cells. Of these isolates, eudebeiolide D exhibited an inhibitory effect with the IC50 value of 1.1 μM.
authors: Natural Product Research Center, Korea Research Institute of Bioscience and Biotechnology, 181 Ipsin-gil, Jeongeup-si, Jeonbuk 56212, South Korea; College of Pharmacy, Chungnam National University, Daejeon 34134, South Korea.
authors: Hyun-Jae
authors: HJ
authors: Jang
authors: Natural Product Research Center, Korea Research Institute of Bioscience and Biotechnology, 181 Ipsin-gil, Jeongeup-si, Jeonbuk 56212, South Korea.
authors: Hyun-Mee
authors: HM
authors: Oh
authors: Natural Product Research Center, Korea Research Institute of Bioscience and Biotechnology, 181 Ipsin-gil, Jeongeup-si, Jeonbuk 56212, South Korea.
authors: Joo Tae
authors: JT
authors: Hwang
authors: Natural Product Research Center, Korea Research Institute of Bioscience and Biotechnology, 181 Ipsin-gil, Jeongeup-si, Jeonbuk 56212, South Korea.
authors: Mi-Hwa
authors: MH
authors: Kim
authors: Natural Product Research Center, Korea Research Institute of Bioscience and Biotechnology, 181 Ipsin-gil, Jeongeup-si, Jeonbuk 56212, South Korea.
authors: Soyoung
authors: S
authors: Lee
authors: Natural Product Research Center, Korea Research Institute of Bioscience and Biotechnology, 181 Ipsin-gil, Jeongeup-si, Jeonbuk 56212, South Korea.
authors: Kyungsook
authors: K
authors: Jung
authors: College of Pharmacy, Chungnam National University, Daejeon 34134, South Korea.
authors: Young-Ho
authors: YH
authors: Kim
authors: Natural Product Research Center, Korea Research Institute of Bioscience and Biotechnology, 181 Ipsin-gil, Jeongeup-si, Jeonbuk 56212, South Korea. Electronic address: lswdoc@kribb.re.kr.
authors: Seung Woong
authors: SW
authors: Lee
authors: Natural Product Research Center, Korea Research Institute of Bioscience and Biotechnology, 181 Ipsin-gil, Jeongeup-si, Jeonbuk 56212, South Korea. Electronic address: rho-m@kribb.re.kr.
authors: Mun-Chual
authors: MC
authors: Rho
mesh_terms: D018360:Crystallography, X-Ray; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D020128:Inhibitory Concentration 50; D015850:Interleukin-6 / Q000494:pharmacology*; D007783:Lactones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D035261:Plant Components, Aerial / Q000737:chemistry; D050796:STAT3 Transcription Factor / Q000187:drug effects*; D027544:Salvia / Q000737:chemistry*; D045787:Sesquiterpenes, Eudesmane / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*
chemical_list: D004365:Drugs, Chinese Herbal; D015850:Interleukin-6; D007783:Lactones; D050796:STAT3 Transcription Factor; D045787:Sesquiterpenes, Eudesmane; C000614068:eudebeiolide D
keywords: Eudesmane sesquiterpenoids; IL-6; Inflammation; Lamiaceae; STAT3; Salvia plebeia