title: Laterality of motor cortical function measured by transcranial magnetic stimulation threshold tracking.
abstract: Threshold tracking paired-pulse transcranial magnetic stimulation (TTTMS) examines cortical function and is useful for diagnosis of motor neuron disorders. Differences in cortical function have been identified between dominant and non-dominant limbs using constant stimulus methods, but they remain unclear, potentially due to methodological differences. In this study we aimed to clarify differences in cortical function between dominant and non-dominant limbs using TTTMS.
  
  
  
  Single-pulse TMS, TTTMS, and nerve conduction studies were performed in 25 healthy, right-handed participants by recording from the abductor pollicis brevis muscle.
  
  
  
  There were no side-to-side differences observed in resting motor threshold, motor evoked potential (MEP) amplitude, MEP latency, central motor conduction time, cortical silent period, short-interval intracortical inhibition and facilitation, compound muscle action potential (CMAP) amplitude, CMAP latency, F-wave latency, or neurophysiological index.
  
  
  
  These findings suggest that, when using TTTMS, there are no differences in cortical function between dominant and non-dominant hemispheres. Muscle Nerve 55: 424-427, 2017.
authors: Brain and Mind Centre, Sydney Medical School, University of Sydney, 94 Mallett Street, Camperdown, Sydney, New South Wales, 2050, Australia.
authors: Kazumoto
authors: K
authors: Shibuya
authors: Brain and Mind Centre, Sydney Medical School, University of Sydney, 94 Mallett Street, Camperdown, Sydney, New South Wales, 2050, Australia.
authors: Susanna B
authors: SB
authors: Park
authors: Brain and Mind Centre, Sydney Medical School, University of Sydney, 94 Mallett Street, Camperdown, Sydney, New South Wales, 2050, Australia.
authors: James
authors: J
authors: Howells
authors: Brain and Mind Centre, Sydney Medical School, University of Sydney, 94 Mallett Street, Camperdown, Sydney, New South Wales, 2050, Australia.|Prince of Wales Clinical School, University of New South Wales, Sydney, Australia.
authors: William
authors: W
authors: Huynh
authors: Brain and Mind Centre, Sydney Medical School, University of Sydney, 94 Mallett Street, Camperdown, Sydney, New South Wales, 2050, Australia.
authors: Yu-Ichi
authors: YI
authors: Noto
authors: Brain and Mind Centre, Sydney Medical School, University of Sydney, 94 Mallett Street, Camperdown, Sydney, New South Wales, 2050, Australia.
authors: Nortina
authors: N
authors: Shahrizaila
authors: Brain and Mind Centre, Sydney Medical School, University of Sydney, 94 Mallett Street, Camperdown, Sydney, New South Wales, 2050, Australia.
authors: José M
authors: JM
authors: Matamala
authors: Westmead Clinical School, University of Sydney, Sydney, New South Wales, Australia.
authors: Steve
authors: S
authors: Vucic
authors: Brain and Mind Centre, Sydney Medical School, University of Sydney, 94 Mallett Street, Camperdown, Sydney, New South Wales, 2050, Australia.
authors: Matthew C
authors: MC
authors: Kiernan
mesh_terms: D000328:Adult; D000368:Aged; D004576:Electromyography; D019054:Evoked Potentials, Motor / Q000502:physiology*; D005260:Female; D007839:Functional Laterality / Q000502:physiology*; D064368:Healthy Volunteers; D006801:Humans; D008297:Male; D008875:Middle Aged; D009044:Motor Cortex / Q000502:physiology*; D009431:Neural Conduction / Q000502:physiology; D050781:Transcranial Magnetic Stimulation; D055815:Young Adult
keywords: cortex function; handedness; healthy control; intracortical inhibition; laterality; threshold tracking transcranial magnetic stimulation