title: The functions and clinical applications of tumor-derived exosomes.
abstract: Exosomes are extracellular vesicles with diameters ranging from 30 to 150 nm. They can be secreted by all cell types and transfer information in the form of their contents, which include proteins, lipids and nucleic acids, to other cells throughout the body. They have roles in normal physiological processes as well as in disease development. Here, we review recent findings regarding tumor-derived exosomes, including methods for their extraction and preservation. We also describe the actions of exosomes in tumorigenesis. The exosomal antigen-presenting effect during antitumor immune responses and its suppressive function in immune tolerance are discussed. Finally, we describe the potential application of exosomes to cancer therapy and liquid biopsy.
authors: Cancer Institute (Key Laboratory of Cancer Prevention and Intervention, China National Ministry of Education, Key Laboratory of Molecular Biology in Medical Sciences, Zhejiang Province, China), The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
authors: Yingkuan
authors: Y
authors: Shao
authors: Cancer Institute (Key Laboratory of Cancer Prevention and Intervention, China National Ministry of Education, Key Laboratory of Molecular Biology in Medical Sciences, Zhejiang Province, China), The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
authors: Yanwei
authors: Y
authors: Shen
authors: Cancer Institute (Key Laboratory of Cancer Prevention and Intervention, China National Ministry of Education, Key Laboratory of Molecular Biology in Medical Sciences, Zhejiang Province, China), The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
authors: Ting
authors: T
authors: Chen
authors: Cancer Institute (Key Laboratory of Cancer Prevention and Intervention, China National Ministry of Education, Key Laboratory of Molecular Biology in Medical Sciences, Zhejiang Province, China), The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
authors: Fei
authors: F
authors: Xu
authors: Department of Biology, University of North Carolina, Chapel Hill, North Carolina, United States of America.
authors: Xuewen
authors: X
authors: Chen
authors: Cancer Institute (Key Laboratory of Cancer Prevention and Intervention, China National Ministry of Education, Key Laboratory of Molecular Biology in Medical Sciences, Zhejiang Province, China), The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
authors: Shu
authors: S
authors: Zheng
mesh_terms: D017951:Antigen Presentation; D000951:Antigens, Neoplasm / Q000276:immunology*; D001691:Biological Therapy; D001706:Biopsy; D063646:Carcinogenesis; D055354:Exosomes / Q000502:physiology*; D006801:Humans; D007108:Immune Tolerance; D007109:Immunity; D007165:Immunosuppression Therapy; D059625:Liquid-Liquid Extraction / Q000379:methods; D009369:Neoplasms / Q000175:diagnosis / Q000473:pathology* / Q000628:therapy
chemical_list: D000951:Antigens, Neoplasm
keywords: clinical applications; exosomes; immunoregulation; metastasis; solid tumor