title: Preventive effects of cedrol against alopecia in cyclophosphamide-treated mice.
abstract: Although numerous hypotheses have been proposed to prevent chemotherapy-induced alopecia (CIA), effective pharmaceuticals have yet to be developed. In our study, the back hairs of C57BL/6 mice were factitiously removed. These mice were then treated with cedrol or minoxidil daily. Mice with early-stage anagen VI hair follicles were treated with cyclophosphamide (CYP, 125mg/kg) to induce alopecia. The CYP-damaged hair follicles were observed and quantified by using a digital photomicrograph. The results demonstrated that the minoxidil-treated mice suffered from complete alopecia similar to the model 6days after CYP administration. Simultaneously, the cedrol-treated (200mg/kg) mice manifested mild alopecia with 40% suppression. Histological observation revealed that anagen hair follicles of the cedrol-pretreated mice (82.5%) likely provided from damage compared with the sparse and dystrophic hair follicles of the model mice (37.0%). Therefore, the use of topical cedrol can prevent hair follicle dystrophy and provide local protection against CIA.
authors: School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, People's Republic of China.
authors: Shan-Shan
authors: SS
authors: Chen
authors: School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, People's Republic of China.
authors: Yan
authors: Y
authors: Zhang
authors: School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, People's Republic of China.
authors: Qiu-Li
authors: QL
authors: Lu
authors: School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, People's Republic of China.
authors: Zhe
authors: Z
authors: Lin
authors: School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, People's Republic of China; Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, People's Republic of China. Electronic address: zyq4885@126.com.
authors: Yuqing
authors: Y
authors: Zhao
mesh_terms: D000505:Alopecia / Q000139:chemically induced / Q000517:prevention & control*; D000818:Animals; D018906:Antineoplastic Agents, Alkylating / Q000633:toxicity*; D029779:Cupressaceae / Q000737:chemistry; D003520:Cyclophosphamide / Q000633:toxicity*; D003877:Dermatitis, Contact / Q000209:etiology / Q000276:immunology; D004195:Disease Models, Animal; D005260:Female; D018859:Hair Follicle / Q000187:drug effects / Q000254:growth & development / Q000473:pathology; D008810:Mice, Inbred C57BL; D018515:Plant Leaves / Q000737:chemistry; D000081223:Polycyclic Sesquiterpenes; D012867:Skin / Q000187:drug effects / Q000276:immunology; D013729:Terpenes / Q000008:administration & dosage / Q000302:isolation & purification / Q000627:therapeutic use* / Q000633:toxicity; D023382:Toxicity Tests, Acute
chemical_list: D018906:Antineoplastic Agents, Alkylating; D000081223:Polycyclic Sesquiterpenes; D013729:Terpenes; C078669:cedrol; D003520:Cyclophosphamide
keywords: Alopecia; Cedrol; Chemotherapy; Cyclophosphamide; Hair follicle