title: Observation of clinical efficacy of photodynamic therapy in 3 patients with refractory plaque-stage mycosis fungoides.
abstract: Mycosis fungoides (MF) is one of the most common cutaneous T cell lymphomas (CTCLs). Currently there are a variety of treatment methods for early-stage MF, most of which are effective. However, some lesions in plaque-stage react poorly to conventional therapy. We chose 3 patients with plaque-stage MF who failed routine therapy, to perform 2-3 times Aminolaevulinic acid-based photodynamic therapy (ALA-PDT). And it turned out that these patients responded well to ALA-PDT: the skin lesions of 2 patients subsided completely, and the last one had more than 75% of the lesions eliminated. In conclusion, compared with traditional therapy, ALA-PDT had tremendous therapeutic effect on refractory plaque-stage MF, with advantages of less side effects and quicker recovery. Therefore, ALA-PDT was an effective method for treating refractory plaque-stage MF.
authors: Department of Dermatology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Bejing, 100730, China.
authors: Dawei
authors: D
authors: Han
authors: School of Medicine, Tsinghua University, Beijing, 100084, China.
authors: Jingwen
authors: J
authors: Xue
authors: Department of Dermatology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Bejing, 100730, China.
authors: Tao
authors: T
authors: Wang
authors: Department of Dermatology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Bejing, 100730, China. Electronic address: yuehualiu@263.net.
authors: Yuehua
authors: Y
authors: Liu
mesh_terms: D000279:Administration, Cutaneous; D000328:Adult; D000622:Aminolevulinic Acid / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009182:Mycosis Fungoides / Q000175:diagnosis / Q000188:drug therapy*; D010778:Photochemotherapy / Q000379:methods*; D017319:Photosensitizing Agents / Q000008:administration & dosage; D012878:Skin Neoplasms / Q000175:diagnosis / Q000188:drug therapy*; D016896:Treatment Outcome
chemical_list: D017319:Photosensitizing Agents; D000622:Aminolevulinic Acid
keywords: Photodynamic therapy; Photosensitizer; Plaque-stage mycosis fungoides; Visible light