title: Acyl-CoA synthetase long-chain 5 genotype is associated with body composition changes in response to lifestyle interventions in postmenopausal women with overweight and obesity: a genetic association study on cohorts Montréal-Ottawa New Emerging Team, and Complications Associated with Obesity.
abstract: Genetic studies on Acyl-CoA Synthetase Long-Chain 5 (ACSL5) demonstrate an association between rs2419621 genotype and rate of weight loss in women with obesity in response to caloric restriction. Our objectives were to (1) confirm results in two different populations of women with overweight and obesity (2) study rs2419621's influence on body composition parameters of women with overweight and obesity following lifestyle interventions.
  
  
  
  rs2419621 genotype was determined in women with overweight and obesity who participated in the Montréal-Ottawa New Emerging Team (MONET n = 137) and Complications Associated with Obesity (CAO n = 37) studies. Genotyping was done using TaqMan MGB probe-based assay. Multiple linear regression analyses were used to test for associations.
  
  
  
  When studying women with overweight and obesity, rs2419621 [T] allele carriers had a significantly greater decrease in visceral fat, absolute and percent fat mass and a greater increase in percent lean mass in response to lifestyle intervention in comparison to non-carriers. Studying only individuals with obesity showed similar results with rs2419621 [T] allele carriers also displaying a significantly greater decrease in body mass index following the lifestyle intervention in comparison to non-carriers.
  
  
  
  Women with overweight and obesity carrying the ACSL5 rs2419621 [T] allele are more responsive to lifestyle interventions in comparison to non-carriers. Conducting such genetic association studies can aid in individualized treatments/interventions catered towards an individual's genotype.
authors: Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON, Canada.|Interdisciplinary School of Health Sciences, University of Ottawa, Ottawa, ON, Canada.
authors: Abishankari
authors: A
authors: Rajkumar
authors: Department of Mathematics and Statistics, University of Ottawa, Ottawa, ON, Canada.
authors: Gilles
authors: G
authors: Lamothe
authors: Interdisciplinary School of Health Sciences, University of Ottawa, Ottawa, ON, Canada.
authors: Pierrette
authors: P
authors: Bolongo
authors: Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON, Canada.
authors: Mary-Ellen
authors: ME
authors: Harper
authors: CHEO Research Institute, Ottawa, ON, Canada.|Department of Pediatrics, University of Ottawa, Ottawa, ON, Canada.|School of Human Kinetics, University of Ottawa, Ottawa, ON, Canada.
authors: Kristi
authors: K
authors: Adamo
authors: School of Human Kinetics, University of Ottawa, Ottawa, ON, Canada.
authors: Éric
authors: É
authors: Doucet
authors: Départment de Nutrition, Université de Montréal, Montreal, QC, Canada.|Institut de Recherches Cliniques de Montréal, Montréal, QC, Canada.
authors: Remi
authors: R
authors: Rabasa-Lhoret
authors: School of Human Kinetics, University of Ottawa, Ottawa, ON, Canada.|Institut de recherche de l'Hôpital Montfort, Hôpital Montfort, Ottawa, ON, Canada.
authors: Denis
authors: D
authors: Prud'homme
authors: Interdisciplinary School of Health Sciences, University of Ottawa, Ottawa, ON, Canada. ftesson@uottawa.ca.|Faculty of Health Sciences, 451 Smyth, Ottawa, ON, K1H 8M5, Canada. ftesson@uottawa.ca.
authors: Frédérique
authors: F
authors: Tesson
mesh_terms: D001823:Body Composition; D031204:Caloric Restriction / Q000379:methods; D002170:Canada; D003066:Coenzyme A Ligases / Q000235:genetics*; D004038:Diet, Reducing / Q000379:methods*; D005260:Female; D056726:Genetic Association Studies; D005838:Genotype; D006801:Humans; D008875:Middle Aged; D009765:Obesity / Q000178:diet therapy* / Q000235:genetics; D050177:Overweight / Q000178:diet therapy* / Q000235:genetics; D020641:Polymorphism, Single Nucleotide; D017698:Postmenopause; D057285:Precision Medicine; D012044:Regression Analysis
chemical_list: D003066:Coenzyme A Ligases; C485465:ACSL5 protein, human
keywords: Fat metabolism; Genotype; Lifestyle modifications; Obesity