title: Biomaterials based on freeze dried surface-deacetylated chitin nanofibers reinforced with sulfobutyl ether β-cyclodextrin gel in wound dressing applications.
abstract: A freeze-dried gel composed of surface-deacetylated chitin nanofibers (SDACNFs), reinforced with an anionic cyclodextrin, sulfobutyl ether β-cyclodextrin (SBE-β-CD) was evaluated for treating wounds in a rat model, and the results were compared with a SDACNFs gel without SBE-β-CD. The incorporation of prednisolone (PD), a poorly water-soluble drug, in both types of gels and its release from the gels were also compared. In both cases, wound areas were decreased and their effect was higher than that of commercially available wound dressings. The rate of release of PD from the freeze-dried SDACNFs/SBE-β-CD was much faster than that form SDACNFs alone without SBE-β-CD, due to fact that the PD is more soluble in the amorphous SBE-β-CD complex compared to the other preparations. The findings indicate that the freeze-dried SDACNFs/SBE-β-CD gel would be beneficial as a new biomaterial for the treatment of wounds and for preparing homogeneous high-content gels that contain poorly water-soluble drugs.
authors: Faculty of Pharmaceutical Sciences, Sojo University, 4-22-1 Ikeda, Kumamoto 860-0082, Japan.
authors: Ryo
authors: R
authors: Tabuchi
authors: Department of Veterinary Clinical Medicine, Tottori University, Tottori 680-8533, Japan.
authors: Kazuo
authors: K
authors: Azuma
authors: Graduate School of Engineering, Tottori University, Tottori 680-8533, Japan.
authors: Ryotaro
authors: R
authors: Izumi
authors: Department of Veterinary Clinical Medicine, Tottori University, Tottori 680-8533, Japan.
authors: Tsubasa
authors: T
authors: Tanou
authors: Department of Veterinary Clinical Medicine, Tottori University, Tottori 680-8533, Japan.
authors: Yoshiharu
authors: Y
authors: Okamoto
authors: Graduate School of Engineering, Tottori University, Tottori 680-8533, Japan.
authors: Tomone
authors: T
authors: Nagae
authors: Faculty of Pharmaceutical Sciences, Sojo University, 4-22-1 Ikeda, Kumamoto 860-0082, Japan.
authors: Daisuke
authors: D
authors: Iohara
authors: Faculty of Pharmaceutical Sciences, Sojo University, 4-22-1 Ikeda, Kumamoto 860-0082, Japan.
authors: Kaneto
authors: K
authors: Uekama
authors: Faculty of Pharmaceutical Sciences, Sojo University, 4-22-1 Ikeda, Kumamoto 860-0082, Japan; DDS Research Institute, Sojo University, 4-22-1 Ikeda, Kumamoto 860-0082, Japan.
authors: Masaki
authors: M
authors: Otagiri
authors: Faculty of Pharmaceutical Sciences, Sojo University, 4-22-1 Ikeda, Kumamoto 860-0082, Japan; DDS Research Institute, Sojo University, 4-22-1 Ikeda, Kumamoto 860-0082, Japan.
authors: Fumitoshi
authors: F
authors: Hirayama
authors: Graduate School of Engineering, Tottori University, Tottori 680-8533, Japan. Electronic address: sifuku@chem.tottori-u.ac.jp.
authors: Shinsuke
authors: S
authors: Ifuku
authors: Faculty of Pharmaceutical Sciences, Sojo University, 4-22-1 Ikeda, Kumamoto 860-0082, Japan; DDS Research Institute, Sojo University, 4-22-1 Ikeda, Kumamoto 860-0082, Japan. Electronic address: anraku@ph.sojo-u.ac.jp.
authors: Makoto
authors: M
authors: Anraku
mesh_terms: D000818:Animals; D001458:Bandages; D001672:Biocompatible Materials / Q000008:administration & dosage / Q000737:chemistry*; D002686:Chitin / Q000008:administration & dosage / Q000737:chemistry*; D065546:Drug Liberation; D005260:Female; D005612:Freeze Drying / Q000379:methods; D057139:Nanofibers / Q000008:administration & dosage / Q000737:chemistry*; D051381:Rats; D017208:Rats, Wistar; D014945:Wound Healing / Q000187:drug effects*; D047392:beta-Cyclodextrins / Q000008:administration & dosage / Q000737:chemistry*
chemical_list: D001672:Biocompatible Materials; D047392:beta-Cyclodextrins; D002686:Chitin; C093196:SBE4-beta-cyclodextrin
keywords: Drug incorporation in gels; Elastic gel; Release properties; Sulfobutyl ether β-cyclodextrin; Surface-deacetylated chitin nanofibers; Wound healing