title: Datasets of genes coexpressed with FBN1 in mouse adipose tissue and during human adipogenesis.
abstract: This article contains data related to the research article entitled "Expression of FBN1 during adipogenesis: relevance to the lipodystrophy phenotype in Marfan syndrome and related conditions" [1]. The article concerns the expression of FBN1, the gene encoding the extracellular matrix protein fibrillin-1, during adipogenesis in vitro and in relation to adipose tissue in vivo. The encoded protein has recently been shown to produce a short glucogenic peptide hormone, (Romere et al., 2016) [2], and this gene is therefore a key gene for regulating blood glucose levels. FBN1 and coexpressed genes were examined in mouse strains and in human cells undergoing adipogenesis. The data show the genes that were coexpressed with FBN1, including genes coding for other connective tissue proteins and the proteases that modify them and for the transcription factors that control their expression. Data analysed were derived from datasets available in the public domain and the analysis highlights the utility of such datasets for ongoing analysis and hence reduction in the use of experimental animals.
authors: The Roslin Institute, University of Edinburgh, Easter Bush, EH25 9RG, UK.
authors: Margaret R
authors: MR
authors: Davis
authors: RIKEN Center for Life Science Technologies (Division of Genomic Technologies) (CLST (DGT)), 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan.
authors: Erik
authors: E
authors: Arner
authors: Centre for Clinical Brain Sciences, University of Edinburgh, Chancellors Building, 49 Little France Crescent, Edinburgh, EH16 4SB, UK.
authors: Cairnan R E
authors: CR
authors: Duffy
authors: Centre for Clinical Brain Sciences, University of Edinburgh, Chancellors Building, 49 Little France Crescent, Edinburgh, EH16 4SB, UK.
authors: Paul A
authors: PA
authors: De Sousa
authors: Department of Medicine, Huddinge (Med H), Karolinska Universitetssjukhuset Huddinge, 141 86 Stockholm, Sweden.
authors: Ingrid
authors: I
authors: Dahlman
authors: Department of Medicine, Huddinge (Med H), Karolinska Universitetssjukhuset Huddinge, 141 86 Stockholm, Sweden.
authors: Peter
authors: P
authors: Arner
authors: The Roslin Institute, University of Edinburgh, Easter Bush, EH25 9RG, UK.
authors: Kim M
authors: KM
authors: Summers