title: Cholesteryl Ester Transfer Protein Inhibitors: Trials and Tribulations.
abstract: The cholesteryl ester transfer protein (CETP) is a plasma protein that plays an important role in the transfer of lipids between plasma lipoproteins. The CETP inhibitors have been widely studied as a pharmacologic therapy to target plasma cholesterol in order to reduce the risk of atherosclerotic cardiovascular disease . Using CETP inhibitors as cholesterol modifiers was based on the genetic research that found correlations between CETP activity and cholesterol levels. Although CETP inhibitors are successful at altering targeted cholesterol markers, recent phase 3 outcome trials have shown limited benefit on cardiovascular outcomes when combined with the current standard of care. We discuss the science of CETP inhibition, compare the CETP inhibitors developed (torcetrapib, evacetrapib, dalcetrapib, and anacetrapib), the findings from the CETP inhibitor trials, and the future outlook for CETP inhibitors in cholesterol modification.
authors: 1 Chicago Medical School, Rosalind Franklin University of Medicine and Science, North Chicago, IL, USA.
authors: Julian Hardy
authors: JH
authors: McLain
authors: 1 Chicago Medical School, Rosalind Franklin University of Medicine and Science, North Chicago, IL, USA.
authors: Andrew Jacob
authors: AJ
authors: Alsterda
authors: 2 Captain James A. Lovell Federal Health Care Center, North Chicago, IL, USA.
authors: Rohit R
authors: RR
authors: Arora
keywords: atherosclerosis; cardiovascular disease; hypercholesterolemia