title: Dynamically Arranging Gold Nanoparticles on DNA Origami for Molecular Logic Gates.
abstract: In molecular engineering, DNA molecules have been extensively studied owing to their capacity for accurate structural control and complex programmability. Recent studies have shown that the versatility and predictability of DNA origami make it an excellent platform for constructing nanodevices. In this study, we developed a strand-displacing strategy to selectively and dynamically release specific gold nanoparticles (AuNPs) on a rectangular DNA origami. A set of DNA logic gates ("OR", "AND", and "three-input majority gate") were established based on this strategy, in which computing results were identified by disassembly between the AuNPs and DNA origami. The computing results were detected using experimental approaches such as gel electrophoresis and transmission electron microscopy (TEM). This method can be used to assemble more complex nanosystems and may have potential applications for molecular engineering.
authors: School of Control and Computer Engineering, North China Electric Power University , Beijing 102206 , China.
authors: Jing
authors: J
authors: Yang
authors: School of Control and Computer Engineering, North China Electric Power University , Beijing 102206 , China.|Institute of Software, School of Electronics Engineering and Computer Science, Key Laboratory of High Confidence Software Technologies of Ministry of Education, Peking University , Beijing 100871, China.
authors: Zhichao
authors: Z
authors: Song
authors: School of Control and Computer Engineering, North China Electric Power University , Beijing 102206 , China.
authors: Shi
authors: S
authors: Liu
authors: Key Laboratory of Advanced Design and Intelligent Computing, Dalian University, Ministry of Education , Dalian 116622, China.
authors: Qiang
authors: Q
authors: Zhang
authors: Institute of Software, School of Electronics Engineering and Computer Science, Key Laboratory of High Confidence Software Technologies of Ministry of Education, Peking University , Beijing 100871, China.
authors: Cheng
authors: C
authors: Zhang
mesh_terms: D004247:DNA / Q000737:chemistry*; D006046:Gold; D008128:Logic; D053768:Metal Nanoparticles; D046529:Microscopy, Electron, Transmission
chemical_list: D006046:Gold; D004247:DNA
keywords: DNA origami; DNA/Au conjugate; logic gate; strand displacement; transmission electron microscopy