title: Optimal temperature management in aortic arch operations.
abstract: Hypothermic circulatory arrest is a critical component of aortic arch procedures, without which these operations could not be safely performed. Despite the use of hypothermia as a protective adjunct for organ preservation, aortic arch surgery remains complex and is associated with numerous complications despite years of surgical advancement. Deep hypothermic circulatory arrest affords the surgeon a safe period of time to perform the arch reconstruction, but this interruption of perfusion comes at a high clinical cost: stroke, paraplegia, and organ dysfunction are all potential-associated complications. Retrograde cerebral perfusion was subsequently developed as a technique to improve upon the rates of neurologic dysfunction, but was done with only modest success. Selective antegrade cerebral perfusion, on the other hand, has consistently been shown to be an effective form of cerebral protection over deep hypothermia alone, even during extended periods of circulatory arrest. A primary disadvantage of using deep hypothermic circulatory arrest is the prolonged bypass times required for cooling and rewarming which adds significantly to the morbidity associated with these procedures, especially coagulopathic bleeding and organ dysfunction. In an effort to mitigate this problem, the degree of hypothermia at the time of the initial circulatory arrest has more recently been reduced in multiple centers across the globe. This technique of moderate hypothermic circulatory arrest in combination with adjunctive brain perfusion techniques has been shown to be safe when performing aortic arch operations. In this review, we will discuss the evolution of these protection strategies as well as their relative strengths and weaknesses.
authors: Division of Cardiothoracic Surgery, Emory University School of Medicine, Atlanta, USA.
authors: Michael O
authors: MO
authors: Kayatta
authors: Division of Cardiothoracic Surgery, Emory University School of Medicine, Atlanta, USA. epchen@emory.edu.
authors: Edward P
authors: EP
authors: Chen
mesh_terms: D001013:Aorta, Thoracic / Q000601:surgery*; D001831:Body Temperature; D001921:Brain / Q000098:blood supply; D002560:Cerebrovascular Circulation; D050792:Circulatory Arrest, Deep Hypothermia Induced / Q000009:adverse effects / Q000379:methods*; D006801:Humans; D010264:Paraplegia / Q000517:prevention & control; D020521:Stroke / Q000517:prevention & control; D013696:Temperature
keywords: Aortic arch surgery; Cerebral perfusion; Circulatory arrest; Hypothermia; Temperature management