title: Host-guest inclusion system of rhein with polyamine-modified β-cyclodextrins: characterization and cytotoxicity.
abstract: We report the preparation of inclusion complexes between rhein and four polyamine-modified β-cyclodextrins, namely amino-β-cyclodextrins (NH2-βCD), ethylenediamine-β-cyclodextrins (EN-βCD), diethylenetriamine-β-cyclodextrins (DETA-βCD) and triethylenetetramine-β-cyclodextrins (TETA-βCD) using suspension method. The solution and solid state forms of the inclusion complexes of rhein with polyamine-β-cyclodextrins were characterized by multiple techniques. Additionally, saturated solution and MTT methods were implemented to assess the water solubilization and in vitro cytotoxicity of the inclusion complexes, respectively. The results suggested that rhein was encapsulated within the CD cavity to form a 1:1 host-guest inclusion complex. Notably, a significant enhancement of the water solubility and in vitro cytotoxicity of rhein was found in the form of inclusion complex with polyamine-β-cyclodextrin.
authors: a Faculty of Life Science and Technology , Kunming University of Science and Technology , Kunming , P.R. China.
authors: Pin
authors: P
authors: Lv
authors: a Faculty of Life Science and Technology , Kunming University of Science and Technology , Kunming , P.R. China.
authors: Manshuo
authors: M
authors: Liu
authors: a Faculty of Life Science and Technology , Kunming University of Science and Technology , Kunming , P.R. China.
authors: Rongqiang
authors: R
authors: Liao
authors: b Faculty of Chemical Engineering , Kunming University of Science and Technology , Kunming , P.R. China.
authors: Yulin
authors: Y
authors: Zhao
authors: a Faculty of Life Science and Technology , Kunming University of Science and Technology , Kunming , P.R. China.
authors: Xiali
authors: X
authors: Liao
authors: a Faculty of Life Science and Technology , Kunming University of Science and Technology , Kunming , P.R. China.
authors: Chuanzhu
authors: C
authors: Gao
authors: a Faculty of Life Science and Technology , Kunming University of Science and Technology , Kunming , P.R. China.
authors: Bo
authors: B
authors: Yang
mesh_terms: D000880:Anthraquinones / Q000633:toxicity; D004791:Enzyme Inhibitors / Q000633:toxicity; D011073:Polyamines; D012995:Solubility; D047392:beta-Cyclodextrins
chemical_list: D000880:Anthraquinones; D004791:Enzyme Inhibitors; D011073:Polyamines; D047392:beta-Cyclodextrins; C020491:rhein
keywords: Polyamine-β-cyclodextrins; cytotoxicity; inclusion complex; rhein; solubilization