title: The translation factors of Drosophila melanogaster.
abstract: Synthesis of polypeptides from mRNA (translation) is a fundamental cellular process that is coordinated and catalyzed by a set of canonical 'translation factors'. Surprisingly, the translation factors of Drosophila melanogaster have not yet been systematically identified, leading to inconsistencies in their nomenclature and shortcomings in functional (Gene Ontology, GO) annotations. Here, we describe the complete set of translation factors in D. melanogaster, applying nomenclature already in widespread use in other species, and revising their functional annotation. The collection comprises 43 initiation factors, 12 elongation factors, 3 release factors and 6 recycling factors, totaling 64 of which 55 are cytoplasmic and 9 are mitochondrial. We also provide an overview of notable findings and particular insights derived from Drosophila about these factors. This catalog, together with the incorporation of the improved nomenclature and GO annotation into FlyBase, will greatly facilitate access to information about the functional roles of these important proteins.
authors: a FlyBase, Department of Physiology , Development and Neuroscience, University of Cambridge , Cambridge , UK.
authors: Steven J
authors: SJ
authors: Marygold
authors: a FlyBase, Department of Physiology , Development and Neuroscience, University of Cambridge , Cambridge , UK.
authors: Helen
authors: H
authors: Attrill
authors: b Department of Biology , McGill University , Bellini Life Sciences Complex, Montreal, Quebec , Canada.
authors: Paul
authors: P
authors: Lasko
mesh_terms: D000818:Animals; D029721:Drosophila Proteins / Q000378:metabolism*; D004331:Drosophila melanogaster / Q000235:genetics / Q000378:metabolism*; D039642:Eukaryotic Initiation Factors / Q000378:metabolism; D024101:Mitochondrial Proteins / Q000378:metabolism; D010445:Peptide Elongation Factors / Q000378:metabolism; D014176:Protein Biosynthesis; D012269:Ribosomal Proteins / Q000378:metabolism
chemical_list: D029721:Drosophila Proteins; D039642:Eukaryotic Initiation Factors; D024101:Mitochondrial Proteins; D010445:Peptide Elongation Factors; D012269:Ribosomal Proteins
keywords: Drosophila melanogaster; translation elongation factor; translation initiation factor; translation recycling factor; translation release factor; translation termination factor