title: Anticompulsive Activity of a New Pyrazolo[C]Pyridine Derivative GIZh-72 under Conditions of Unpredictable Chronic Mild Stress.
abstract: Anticompulsive activity of a novel compound GIZh-72 (4,6-dimethyl-2-(4-chlorphenyl)-2,3-dihydro-1H-pyrazolo[4,3-C]Pyridine-3-on, chloral hydrate) in a dose of 20 mg/kg (single, subchronic, and chronic administration) in comparison with fluvoxamine (25 mg/kg) was studied in the marble burying test in the model of unpredictable chronic mild stress on BALB/c mice. GIZh-72 produced an anticompulsive effect that increased with increasing treatment duration under stress conditions in contrast to fluvoxamine that induced inversion of this effect after long-term administration. Neuroleptic activity of GIZh-72 in doses of 20 and 40 mg/kg was studied on the model of apomorphine-induced climbing in C57Bl/6 mice. In contrast to haloperidol (0.5 mg/kg), GIZh-72 exhibited no neuroleptic properties. Our results indicate that GIZh-72 holds much promise for pharmacotherapy of obsessive-compulsive disorder.
authors: V. V. Zakusov Research Institute of Pharmacology, Moscow, Russia. kunvi@mail.ru.
authors: N V
authors: NV
authors: Kudryashov
authors: V. V. Zakusov Research Institute of Pharmacology, Moscow, Russia.
authors: T S
authors: TS
authors: Kalinina
authors: V. V. Zakusov Research Institute of Pharmacology, Moscow, Russia.
authors: L A
authors: LA
authors: Zhmurenko
authors: V. V. Zakusov Research Institute of Pharmacology, Moscow, Russia.
authors: T A
authors: TA
authors: Voronina
mesh_terms: D000818:Animals; D014151:Anti-Anxiety Agents / Q000737:chemistry / Q000627:therapeutic use*; D001522:Behavior, Animal / Q000187:drug effects; D004195:Disease Models, Animal; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D011725:Pyridines / Q000737:chemistry; D013315:Stress, Psychological / Q000188:drug therapy*
chemical_list: D014151:Anti-Anxiety Agents; D011725:Pyridines; C023666:pyridine
keywords: anxiolytics; fluvoxamine; mice; obsessive-compulsive disorder; stress