title: An Update on Inflamm-Aging: Mechanisms, Prevention, and Treatment.
abstract: Inflamm-aging is a challenging and promising new branch of aging-related research fields that includes areas such as immunosenescence. Increasing evidence indicates that inflamm-aging is intensively associated with many aging diseases, such as Alzheimer's disease, atherosclerosis, heart disease, type II diabetes, and cancer. Mounting studies have focused on the role of inflamm-aging in disease progression and many advances have been made in the last decade. However, the underlying mechanisms by which inflamm-aging affects pathological changes and disease development are still unclear. Here, we review studies of inflamm-aging that explore the concept, pathological features, mechanisms, intervention, and the therapeutic strategies of inflamm-aging in disease progression.
authors: Department of Geriatrics, Shanghai Institute of Geriatrics, Huadong Hospital, Fudan University, Shanghai 200040, China.
authors: Shijin
authors: 0000-0002-2548-393X
authors: S
authors: Xia
authors: Department of Information, Chengdu Military General Hospital, Chengdu 610083, China.
authors: Xinyan
authors: 0000-0002-9210-1268
authors: X
authors: Zhang
authors: Department of Geriatrics, Shanghai Institute of Geriatrics, Huadong Hospital, Fudan University, Shanghai 200040, China.
authors: Songbai
authors: 0000-0003-4453-4664
authors: S
authors: Zheng
authors: Department of Maternal-Fetal Medicine Pregnancy Research Centre and Department of Obstetrics and Gynaecology, University of Melbourne, Royal Women's Hospital, Parkville, VIC 3052, Australia.
authors: Ramin
authors: 0000-0003-1420-6934
authors: R
authors: Khanabdali
authors: Department of Maternal-Fetal Medicine Pregnancy Research Centre and Department of Obstetrics and Gynaecology, University of Melbourne, Royal Women's Hospital, Parkville, VIC 3052, Australia.
authors: Bill
authors: 0000-0002-0132-9858
authors: B
authors: Kalionis
authors: Department of Geriatrics, Shanghai Institute of Geriatrics, Huadong Hospital, Fudan University, Shanghai 200040, China.
authors: Junzhen
authors: J
authors: Wu
authors: Department of Neurology, Zhongshan Hospital, Fudan University, Shanghai 200032, China.
authors: Wenbin
authors: 0000-0002-2502-0177
authors: W
authors: Wan
authors: School of Acupuncture, Massage and Rehabilitation, Yunnan University of Traditional Chinese Medicine, Kunming 650500, China.
authors: Xiantao
authors: 0000-0002-8981-1090
authors: X
authors: Tai
mesh_terms: D000375:Aging; D000818:Animals; D015415:Biomarkers; D016207:Cytokines / Q000378:metabolism; D004198:Disease Susceptibility; D006801:Humans; D007249:Inflammation / Q000209:etiology* / Q000517:prevention & control* / Q000628:therapy*; D010084:Oxidation-Reduction; D012106:Research; D015398:Signal Transduction; D013312:Stress, Physiological
chemical_list: D015415:Biomarkers; D016207:Cytokines