title: Erianin inhibits the proliferation of T47D cells by inhibiting cell cycles, inducing apoptosis and suppressing migration.
abstract: Erianin is a natural product extracted from Dendrobiumchrysotoxum. To investigate the antitumor activity of Erianin in estrogen receptor (ER) positive breast cancer, we treated T47D cells with Erianin and evaluated the effects of Erianin treatment on multiple cancer-associated pathways. Erianin inhibited the proliferation of T47D cells effectively. Erianin induced apoptosis in T47D cells through reducing Bcl-2 expression and activating caspase signaling. Furthermore, it also suppressed the expression of CDKs and caused cell cycle arrest. In addition, Erianin treatment suppressed the migration of T47D cells, most likely through regulating the homeostatic expression of MPP and TIMP. Meanwhile, Erianin did not affect the proliferation of normal breast epithelial cell line MCF10A. Together, these results demonstrated that Erianin might have the potential to be an effective drug to treat the ER positive breast cancer.
authors: School of Life Sciences, Jilin University Changchun 130012, China.
authors: Jing
authors: J
authors: Sun
authors: School of Life Sciences, Jilin UniversityChangchun 130012, China; Key Laboratory for Molecular Enzymology and Engineering of Ministry of Education, Jilin UniversityChangchun 130012, China.
authors: Xueqi
authors: X
authors: Fu
authors: School of Life Sciences, Jilin University Changchun 130012, China.
authors: Yongsen
authors: Y
authors: Wang
authors: School of Life Sciences, Jilin University Changchun 130012, China.
authors: Ye
authors: Y
authors: Liu
authors: School of Life Sciences, Jilin University Changchun 130012, China.
authors: Yu
authors: Y
authors: Zhang
authors: School of Life Sciences, Jilin University Changchun 130012, China.
authors: Tian
authors: T
authors: Hao
authors: School of Life Sciences, Jilin UniversityChangchun 130012, China; Key Laboratory for Molecular Enzymology and Engineering of Ministry of Education, Jilin UniversityChangchun 130012, China.
authors: Xin
authors: X
authors: Hu
keywords: Erianin; apoptosis; breast cancer; estrogen receptor; proliferation