title: Detection of cancer cells and tumor markers in gastric lavage of patients with gastric cancer: Do these findings have a clinicopathological significance and oncological implication?
abstract: Although decreasing in the incidence over the last years, currently gastric adenocarcinoma represents the second cause of cancer related-death worldwide. Further knowledge and novel therapies are desperately needed in order to make the prognosis of these patients more acceptable. Infact, even though in recent years numerous staging parameters have been largely studied and unanimously recognized for their clinical and prognostic value, today too many shadows still exist around the capacity to predict exactly the natural history or post-treatment behavior of this cancer even among patients of the same stage. This study has identified the presence of isolated cancer cells as well as tumor markers (CEA, Ca 19.9, Ca 72.4 and Ca 50) from the gastric lavage of patients affected by gastric adenocarcinoma. Such findings led to the hypothesis that endoluminal exfoliation of neoplastic cells and the release of their products (tumor markers) into the gastric juice might be an expression of neoplastic behavior as well as aggressive malignancy. Should this hypothesis become a reality, some important progress could be made in the knowledge, staging, prediction as well as management and follow-up of this inauspicious type of cancer.
authors: Department of Medical and Surgical Sciences and Translational Medicine, Department of Emergency Surgery, Faculty of Medicine and Psychology, University "Sapienza", St. Andrea Hospital, via di Grottarossa 1035-39, Rome 00189, Italy. Electronic address: aresedo1992@yahoo.it.
authors: Edoardo
authors: E
authors: Virgilio
authors: Department of Clinical and Molecular Medicine, Faculty of Medicine and Psychology, University "Sapienza", St. Andrea Hospital, via di Grottarossa 1035-39, Rome 00189, Italy.
authors: Enrico
authors: E
authors: Giarnieri
authors: Department of Clinical and Molecular Medicine, Faculty of Medicine and Psychology, University "Sapienza", St. Andrea Hospital, via di Grottarossa 1035-39, Rome 00189, Italy.
authors: Monica
authors: M
authors: Montagnini
authors: Department of Clinical and Molecular Medicine, Faculty of Medicine and Psychology, University "Sapienza", St. Andrea Hospital, via di Grottarossa 1035-39, Rome 00189, Italy.
authors: Rosaria
authors: R
authors: D'Urso
authors: Department of Clinical and Molecular Medicine, Faculty of Medicine and Psychology, University "Sapienza", St. Andrea Hospital, via di Grottarossa 1035-39, Rome 00189, Italy.
authors: Antonella
authors: A
authors: Proietti
authors: Department of Clinical and Molecular Medicine, Faculty of Medicine and Psychology, University "Sapienza", St. Andrea Hospital, via di Grottarossa 1035-39, Rome 00189, Italy.
authors: Alessandra
authors: A
authors: Mesiti
authors: Department of Clinical and Molecular Medicine, Faculty of Medicine and Psychology, University "Sapienza", St. Andrea Hospital, via di Grottarossa 1035-39, Rome 00189, Italy.
authors: Maria Rosaria
authors: MR
authors: Giovagnoli
authors: Department of Medical and Surgical Sciences and Translational Medicine, Department of Emergency Surgery, Faculty of Medicine and Psychology, University "Sapienza", St. Andrea Hospital, via di Grottarossa 1035-39, Rome 00189, Italy.
authors: Paolo
authors: P
authors: Mercantini
authors: Department of Medical and Surgical Sciences and Translational Medicine, Department of Emergency Surgery, Faculty of Medicine and Psychology, University "Sapienza", St. Andrea Hospital, via di Grottarossa 1035-39, Rome 00189, Italy.
authors: Marco
authors: M
authors: Cavallini
authors: Department of Medical and Surgical Sciences and Translational Medicine, Department of Emergency Surgery, Faculty of Medicine and Psychology, University "Sapienza", St. Andrea Hospital, via di Grottarossa 1035-39, Rome 00189, Italy.
authors: Genoveffa
authors: G
authors: Balducci
mesh_terms: D000328:Adult; D000368:Aged; D000818:Animals; D014408:Biomarkers, Tumor / Q000378:metabolism; D005260:Female; D005751:Gastric Lavage; D006801:Humans; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011379:Prognosis; D013274:Stomach Neoplasms / Q000175:diagnosis* / Q000235:genetics / Q000378:metabolism; D016896:Treatment Outcome
chemical_list: D014408:Biomarkers, Tumor