title: [An experimental in vitro study of antioxidant and antiradical properties of cytoflavin, vinpocetine, actovegin and ethylmethylhydroxypyridine succinate].
abstract: OBJECTIVE
  To investigate experimentally in vitro the antioxidant and anti-radical activity of several drugs.
  
  
  METHODS
  Antioxidant activity was assessed by induced luminol-dependent chemiluminescence (CL). An impact on the generation of reactive oxygen species (O2-, OH, 1D, H2O2, HClO) and their ability to inhibit the auto-oxidation of quercetin combined with the generation of superoxide radical anion were determined. Anti-radical activity was studied by the method of restoring a stable radical α-α-diphenyl-β-picryl hydrazine (DPPH) molecule of the alleged anti-oxidant.
  
  
  CONCLUSIONS
  The many-sided action of the drugs on the products of free radicals generated in the in vitro experiments has been shown. Only cytoflavin has the highest total antioxidant and antiradical activity. Vinpocetine has demonstrated similar, but somewhat less pronounced, activity. Ethylmethylhydroxypyridine succinate and actovegin have shown only the nonspecific superoxide dismutase activity which was by times lower than that of cytoflavin and vinpocetine.
authors: St. Petersburg V.M. Bekhterev Psychoneurological Research Institute, St. Petersburg, Russia.
authors: Trofimova S
authors: TS
authors: A
authors: St. Petersburg V.M. Bekhterev Psychoneurological Research Institute, St. Petersburg, Russia.
authors: Dubinina E
authors: DE
authors: E
authors: St. Petersburg V.M. Bekhterev Psychoneurological Research Institute, St. Petersburg, Russia.
authors: Balunov O
authors: BO
authors: A
authors: State Research Institute of Highly Pure Biopreparations of FMBA, St. Petersburg, Russia.
authors: Leonova N
authors: LN
authors: V
mesh_terms: D000975:Antioxidants / Q000494:pharmacology*; D004338:Drug Combinations; D005486:Flavin Mononucleotide / Q000494:pharmacology*; D006418:Heme / Q000031:analogs & derivatives* / Q000494:pharmacology; D006801:Humans; D007290:Inosine Diphosphate / Q000494:pharmacology*; D049449:Luminescence; D008165:Luminol / Q000737:chemistry; D009504:Neutrophils / Q000187:drug effects / Q000378:metabolism; D009536:Niacinamide / Q000494:pharmacology*; D010084:Oxidation-Reduction; D011725:Pyridines / Q000494:pharmacology*; D011794:Quercetin / Q000737:chemistry; D017382:Reactive Oxygen Species / Q000378:metabolism*; D020521:Stroke / Q000097:blood; D013386:Succinates / Q000494:pharmacology*; D014748:Vinca Alkaloids / Q000494:pharmacology*
chemical_list: D000975:Antioxidants; D004338:Drug Combinations; D011725:Pyridines; D017382:Reactive Oxygen Species; D013386:Succinates; D014748:Vinca Alkaloids; C507879:cytoflavin; C517040:ethylmethylhydroxypyridine succinate; D009536:Niacinamide; D006418:Heme; C013983:vinpocetine; D008165:Luminol; C015646:Actovegin; D005486:Flavin Mononucleotide; D007290:Inosine Diphosphate; D011794:Quercetin