title: [Some aspects of examining the images of tracer hyperfixation foci in osteoscintigrams by computer-assisted automated analysis].
abstract: OBJECTIVE
  to analyze the numerical characteristics of bone metastases according to scintigraphic data.
  
  
  METHODS
  Computer-assisted automated analysis was used to examine planar skeletal osteoscintigrams in patients with breast cancer who had both complete remission and disease progression with skeletal metastases. Brightness in the image was used as an analyzed indicator.
  
  
  RESULTS
  Examination of physiological tracer accumulation in patients without skeletal metastases suggests that there is a wide variability of brightness values in the scintigrams of individual skeletal areas. At the same time, the skeletal anatomic areas show significant differences in the average image brightness values (p < 0.01). In virtually all skeletal areas, the average brightness values in the pathological tracer hyperfixation foci (HFFs) in the scintigrams are dominant over the similar values of physiological HFFs.
  
  
  CONCLUSIONS
  There is a direct relationship between the tracer accumulation levels in the skeletal areas without metastatic involvement and the bone metastases occurring in the same areas.
authors: N E
authors: NE
authors: Kosykh
authors: S Z
authors: SZ
authors: Savin
authors: V L
authors: VL
authors: Kovalenko
authors: T P
authors: TP
authors: Potapova
authors: K A
authors: KA
authors: Litvinov
mesh_terms: D000328:Adult; D001859:Bone Neoplasms / Q000000981:diagnostic imaging / Q000556:secondary; D001943:Breast Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D011849:Radioactive Tracers; D011877:Radionuclide Imaging / Q000379:methods*; D019275:Radiopharmaceuticals / Q000494:pharmacology
chemical_list: D011849:Radioactive Tracers; D019275:Radiopharmaceuticals