title: [Radiotherapy of larynx cancers].
abstract: Intensity-modulated radiotherapy is the gold standard in the treatment of larynx cancers (except T1 glottic tumour). Early T1 and T2 tumours may be treated by exclusive radiation or surgery. For tumours requiring total laryngectomy (T2 or T3), induction chemotherapy followed by exclusive radiotherapy or concurrent chemoradiotherapy is possible. For T4 tumour, surgery must be proposed. The treatment of lymph nodes is based on the initial treatment of the primary tumour. In non-surgical procedure, in case of sequential radiotherapy, the curative dose is 70Gy and the prophylactic dose is 50Gy. An integrated simultaneous boost radiotherapy is allowed (70Gy in 2Gy per fraction and 56Gy in 1.8Gy per fraction or 70Gy in 2.12Gy per fraction). Postoperatively, radiotherapy is used in locally advanced cancer with dose levels based on pathologic criteria (66Gy for R1 resection, 50 to 54Gy for complete resection). Volume delineation was based on guidelines.
authors: Centre Jean-Bernard, clinique Victor-Hugo, 9, rue Beauverger, 72000 Le Mans, France; Service de radiothérapie, hôpital Bretonneau, centre régional universitaire de cancérologie Henry-S.-Kaplan, CHRU de Tours, 2, boulevard Tonnellé, 37044 Tours, France. Electronic address: pointr_y@yahoo.fr.
authors: Y
authors: Y
authors: Pointreau
authors: Centre Jean-Bernard, clinique Victor-Hugo, 9, rue Beauverger, 72000 Le Mans, France.
authors: C
authors: C
authors: Lafond
authors: Centre Jean-Bernard, clinique Victor-Hugo, 9, rue Beauverger, 72000 Le Mans, France.
authors: F
authors: F
authors: Legouté
authors: Centre Jean-Bernard, clinique Victor-Hugo, 9, rue Beauverger, 72000 Le Mans, France.
authors: P
authors: P
authors: Trémolières
authors: Département de radiothérapie, institut Jean-Godinot, 1, rue Koenig, 51056 Reims, France.
authors: S
authors: S
authors: Servagi-Vernat
authors: Service d'oncologie radiothérapie, hôpital européen Georges-Pompidou, 20, rue Leblanc, 75015 Paris, France; Université Paris-Descartes, Sorbonne Paris cité, 75015 Paris, France.
authors: P
authors: P
authors: Giraud
authors: Département de radiothérapie, centre Georges-François-Leclerc, 1, rue Professeur-Marion, 21079 Dijon, France.
authors: P
authors: P
authors: Maingon
authors: Service de radiothérapie, hôpital Bretonneau, centre régional universitaire de cancérologie Henry-S.-Kaplan, CHRU de Tours, 2, boulevard Tonnellé, 37044 Tours, France.
authors: G
authors: G
authors: Calais
authors: Département de radiothérapie, centre Jean-Perrin, 58, rue Montalembert, BP 5026, 63011 Clermont-Ferrand cedex 1, France.
authors: M
authors: M
authors: Lapeyre
mesh_terms: D059248:Chemoradiotherapy; D003131:Combined Modality Therapy; D019583:Dose Fractionation, Radiation; D006801:Humans; D007822:Laryngeal Neoplasms / Q000188:drug therapy / Q000532:radiotherapy* / Q000601:surgery; D007825:Laryngectomy; D015182:Lymphatic Irradiation; D008207:Lymphatic Metastasis; D058958:Organs at Risk; D011832:Radiation Injuries / Q000517:prevention & control; D011879:Radiotherapy Dosage; D011880:Radiotherapy Planning, Computer-Assisted; D018714:Radiotherapy, Adjuvant / Q000379:methods; D061089:Radiotherapy, Image-Guided / Q000379:methods; D050397:Radiotherapy, Intensity-Modulated / Q000009:adverse effects / Q000379:methods* / Q000592:standards
keywords: Delineation; Dose; Doses; Délinéation; Indication; Indications; Intensity-modulated radiotherapy; Larynx cancer; Radiothérapie conformationnelle avec modulation d’intensité; Tumeurs laryngées