title: Usefulness of the d-ROMs test for prediction of cardiovascular events.
abstract: BACKGROUND
  d-ROMs test developed to determine the degree of individual oxidative stress may predict cardiovascular events.
  
  
  RESULTS
  265 patients (204 men, 61 women; age, 65±13years) who had been treated for cardiovascular disease were divided evenly by quartile of baseline d-ROMs levels, and were followed up. During the observation periods of 2.66±1.47years, there were 14 (5%) deaths, 8 (3%) cardiovascular deaths, 13 (5%) major adverse cardiovascular events (MACEs), and 51 (19%) all cardiovascular events including heart failure, cardiovascular surgery, and revascularization. Log-rank tests demonstrated that the patients in the 4th quartile (d-ROMs≧395.00U.CARR) had a higher incidence rate of cardiovascular death than those in the 2nd quartile (d-ROMs 286.00-335.00, p=0.022). In multivariate Cox regression analysis, even after adjustment for age, sex, coronary risk factors, C-reactive protein, and renal function, high d-ROMs was a risk factor for all-cause death [adjusted HR of 4th vs. 1st quartile, 10.791 (95% confidence interval 1.032-112.805), p=0.047], and all cardiovascular events [HR of 4th vs. 1st quartile, 2.651 (95% confidence interval 1.138-6.177), p=0.024].
  
  
  CONCLUSIONS
  Our results suggest that d-ROMs is a useful oxidative stress marker to assess prognosis and risk of further cardiovascular events.
authors: Department of Intensive Care Medicine, National Defense Medical College, Tokorozawa, Japan. Electronic address: masakinobuyuki@hotmail.com.
authors: Nobuyuki
authors: N
authors: Masaki
authors: Department of Cardiology, National Defense Medical College, Tokorozawa, Japan.
authors: Atsushi
authors: A
authors: Sato
authors: Department of Cardiology, National Defense Medical College, Tokorozawa, Japan.
authors: Syumpei
authors: S
authors: Horii
authors: Department of Cardiology, National Defense Medical College, Tokorozawa, Japan.
authors: Toyokazu
authors: T
authors: Kimura
authors: Department of Cardiology, National Defense Medical College, Tokorozawa, Japan.
authors: Takumi
authors: T
authors: Toya
authors: Department of Cardiology, National Defense Medical College, Tokorozawa, Japan.
authors: Risako
authors: R
authors: Yasuda
authors: Department of Cardiology, National Defense Medical College, Tokorozawa, Japan.
authors: Takayuki
authors: T
authors: Namba
authors: Department of Cardiology, National Defense Medical College, Tokorozawa, Japan.
authors: Hirotaka
authors: H
authors: Yada
authors: Department of Cardiology, National Defense Medical College, Tokorozawa, Japan.
authors: Akio
authors: A
authors: Kawamura
authors: Department of Cardiology, National Defense Medical College, Tokorozawa, Japan.
authors: Takeshi
authors: T
authors: Adachi
mesh_terms: D000368:Aged; D002318:Cardiovascular Diseases / Q000175:diagnosis / Q000378:metabolism / Q000401:mortality / Q000628:therapy; D002423:Cause of Death; D018450:Disease Progression; D005260:Female; D006801:Humans; D007564:Japan / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D009204:Myocardial Revascularization / Q000706:statistics & numerical data; D018384:Oxidative Stress / Q000502:physiology*; D011237:Predictive Value of Tests; D011379:Prognosis; D017382:Reactive Oxygen Species / Q000032:analysis; D018570:Risk Assessment / Q000379:methods; D012307:Risk Factors
chemical_list: D017382:Reactive Oxygen Species
keywords: Oxidative stress; d-ROMs