title: Fluoroquinolone resistance of Streptococcus pneumoniae isolates causing invasive disease: special focus on zabofloxacin.
abstract: The present study examined the in vitro activity of various antibiotics including zabofloxacin, against isolates responsible for invasive pneumococcal diseases. Between 1997 and 2008, a total of 208 isolates were collected from sterile fluids, including blood (n=196, 94.2%), pleural fluid (n=5, 2.4%), cerebrospinal fluid (n=5, 2.4%), and ascites (n=2, 1.0%). Zabofloxacin showed the lowest MIC50 (0.015μg/mL) and MIC90 (0.025μg/mL) values of all the tested antibiotics. Rates of isolates resistant to penicillin (MIC ≥8μg/mL), ceftriaxone (MIC ≥4μg/mL) and levofloxacin (MIC ≥8μg/mL) were 3.4%, 0.4% and 2.0%, respectively. Four isolates (2.0%) were resistant to levofloxacin, and zabofloxacin showed low MICs (range, 0.025-0.125μg/mL). Zabofloxacin shows potent in vitro activity against S. pneumoniae isolates that caused invasive disease, even strains that are resistant to levofloxacin.
authors: Department of Internal Medicine, Soonchunhyang University Bucheon Hospital, Bucheon, Republic of Korea; Department of Infectious Diseases, Asan Medical Center, University of Ulsan College of Medicine, Republic of Korea.
authors: Tark
authors: T
authors: Kim
authors: Center for Antimicrobial Resistance and Microbial Genetics, University of Ulsan, Seoul, Republic of Korea.
authors: Su-Jin
authors: SJ
authors: Park
authors: Department of Infectious Diseases, Asan Medical Center, University of Ulsan College of Medicine, Republic of Korea; Center for Antimicrobial Resistance and Microbial Genetics, University of Ulsan, Seoul, Republic of Korea.
authors: Yong Pil
authors: YP
authors: Chong
authors: Department of Infectious Diseases, Asan Medical Center, University of Ulsan College of Medicine, Republic of Korea; Center for Antimicrobial Resistance and Microbial Genetics, University of Ulsan, Seoul, Republic of Korea.
authors: Ki-Ho
authors: KH
authors: Park
authors: Department of Infectious Diseases, Asan Medical Center, University of Ulsan College of Medicine, Republic of Korea.
authors: Yu-Mi
authors: YM
authors: Lee
authors: Department of Infectious Diseases, Asan Medical Center, University of Ulsan College of Medicine, Republic of Korea.
authors: Hyo-Lim
authors: HL
authors: Hong
authors: Center for Antimicrobial Resistance and Microbial Genetics, University of Ulsan, Seoul, Republic of Korea.
authors: Hee Seung
authors: HS
authors: Kim
authors: Center for Antimicrobial Resistance and Microbial Genetics, University of Ulsan, Seoul, Republic of Korea.
authors: Eun Sil
authors: ES
authors: Kim
authors: Division of Bacterial Respiratory Infections, National Institute of Health, Korea Centers for Disease Control and Prevention, Cheongwon-gun, Republic of Korea.
authors: Sungkyoung
authors: S
authors: Lee
authors: Project Team, Dongwha Pharm Co. Ltd, Seoul, Republic of Korea.
authors: Dong Rack
authors: DR
authors: Choi
authors: Department of Infectious Diseases, Asan Medical Center, University of Ulsan College of Medicine, Republic of Korea.
authors: Sung-Han
authors: SH
authors: Kim
authors: Asan Institute for Life Sciences, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.
authors: Jin-Yong
authors: JY
authors: Jeong
authors: Department of Infectious Diseases, Asan Medical Center, University of Ulsan College of Medicine, Republic of Korea.
authors: Sang-Oh
authors: SO
authors: Lee
authors: Department of Infectious Diseases, Asan Medical Center, University of Ulsan College of Medicine, Republic of Korea.
authors: Sang-Ho
authors: SH
authors: Choi
authors: Department of Infectious Diseases, Asan Medical Center, University of Ulsan College of Medicine, Republic of Korea.
authors: Jun Hee
authors: JH
authors: Woo
authors: Department of Infectious Diseases, Asan Medical Center, University of Ulsan College of Medicine, Republic of Korea; Center for Antimicrobial Resistance and Microbial Genetics, University of Ulsan, Seoul, Republic of Korea. Electronic address: yskim@amc.seoul.kr.
authors: Yang Soo
authors: YS
authors: Kim
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001201:Ascites / Q000382:microbiology; D001769:Blood / Q000382:microbiology; D002555:Cerebrospinal Fluid / Q000382:microbiology; D024841:Fluoroquinolones / Q000493:pharmacokinetics* / Q000494:pharmacology; D006801:Humans; D008826:Microbial Sensitivity Tests; D010996:Pleural Effusion / Q000382:microbiology; D011008:Pneumococcal Infections / Q000382:microbiology*; D013296:Streptococcus pneumoniae / Q000187:drug effects* / Q000302:isolation & purification*
chemical_list: D000900:Anti-Bacterial Agents; D024841:Fluoroquinolones; C480202:zabofloxacin
keywords: Invasive; Resistance; Streptococcus pneumoniae; Zabofloxacin