title: Stereoselective Construction of Spiro-Fused Tricyclic Frameworks by Sequential Reaction of Enynes, Imines, and Diazoalkenes with Rh(I) and Rh(II) Catalysts.
abstract: Stereoselective construction of spiro-fused tricyclic compounds from enynes having a tethered imine with diazoalkenes was achieved by Rh(I)- and Rh(II)-catalyzed sequential reactions. This method consists of three reactions, i.e., Rh(I)-catalyzed cyclization of enynes with a tethered imine, Rh(II)-catalyzed cyclopropanation with diazoalkenes, and Cope rearrangement. Notably, the sequential reactions can be operated in one pot, in which Rh(I) and Rh(II) catalysts work in relay without any serious catalyst deactivation to afford the spirocycles in a stereoselective manner.
authors: Faculty of Pharmaceutical Sciences, Hokkaido University , Sapporo 060-0812, Japan.|Shionogi Innovation Center for Drug Discovery, Shionogi & Company, Ltd. , Sapporo 001-0021, Japan.
authors: Yoshio
authors: Y
authors: Hato
authors: Faculty of Pharmaceutical Sciences, Hokkaido University , Sapporo 060-0812, Japan.
authors: Yoshihiro
authors: Y
authors: Oonishi
authors: Division of Chemical Process Engineering and Frontier Chemistry Center, Faculty of Engineering, Hokkaido University , Sapporo 060-8628, Japan.
authors: Yasunori
authors: Y
authors: Yamamoto
authors: Department of Chemistry, Aichi University of Education , Kariya 448-8542, Japan.
authors: Kiyohiko
authors: K
authors: Nakajima
authors: Faculty of Pharmaceutical Sciences, Hokkaido University , Sapporo 060-0812, Japan.
authors: Yoshihiro
authors: Y
authors: Sato