title: Total synthesis of dehaloperophoramidine using a highly diastereoselective Hosomi-Sakurai reaction.
abstract: The synthesis of dehaloperophoramidine, a non-halogenated derivative of the marine natural product perophoramidine, and its biological activity towards HCT116, HT29 and LoVo colorectal carcinoma cells is reported. A [3,3]-Claisen rearrangement and an epoxide opening/allylsilylation reaction installed the contiguous all-carbon quaternary stereocentres with the required relative stereochemistry.
authors: School of Chemistry and Biomedical Sciences Research Complex, University of St. Andrews and EaStCHEM, St. Andrews, Fife, Scotland KY16 9ST, UK. njw3@st-andrews.ac.uk.
authors: Ross P
authors: RP
authors: Wilkie
authors: Andrew R
authors: AR
authors: Neal
authors: Craig A
authors: CA
authors: Johnston
authors: Nicholas
authors: N
authors: Voute
authors: Christopher S
authors: CS
authors: Lancefield
authors: Matthew D
authors: MD
authors: Stell
authors: Federico
authors: F
authors: Medda
authors: Edward F
authors: EF
authors: Makiyi
authors: Emma M
authors: EM
authors: Turner
authors: O
authors: O
authors: Stephen Ojo
authors: Alexandra M Z
authors: AM
authors: Slawin
authors: Tomas
authors: T
authors: Lebl
authors: Peter
authors: P
authors: Mullen
authors: David J
authors: DJ
authors: Harrison
authors: Chris M
authors: CM
authors: Ireland
authors: Nicholas J
authors: NJ
authors: Westwood