title: Added value of point shear-wave elastography in the diagnosis of acute cholecystitis.
abstract: OBJECTIVE
  To evaluate the added value of point shear-wave elastography (pSWE) in the diagnostic performance of conventional US for diagnosis of acute cholecystitis.
  
  
  METHODS
  B-mode and colour Doppler US and pSWE were performed prospectively in 216 patients with clinically suspected acute cholecystitis. The morphology and mural vascularity of the gallbladder and median shear wave velocity (SWV) of the right liver were evaluated. Two observers independently reviewed conventional US images and subsequently reviewed combined conventional US and pSWE images.
  
  
  RESULTS
  Mean SWVs of the acute cholecystitis group (n = 91) were significantly higher than those of the control group (n = 85) in the right liver within 2 cm lateral to the gallbladder (1.56 versus 1.03 m/s, 1.39 versus 1.04 m/s, P < 0.0001) with a cut-off value of 1.29 or 1.16 m/s. The area under the receiver operating characteristic curve of both observers in the diagnosis of acute cholecystitis improved significantly from 0.790 and 0.777 to 0.963 and 0.962, respectively, after additional review of pSWE images (P < 0.0001). Diagnostic accuracy, sensitivity, specificity, positive and negative predictive values of combined image sets were higher than those of conventional US images alone.
  
  
  CONCLUSIONS
  Adding pSWE to conventional US improves the diagnosis of acute cholecystitis when compared with conventional US alone.
  
  
  CONCLUSIONS
  • In acute cholecystitis, stiffness of the right liver increases adjacent to the gallbladder. • The cut-off value for diagnosing acute cholecystitis was 1.29 or 1.16 m/s. • Adding pSWE to conventional US improves the diagnosis of acute cholecystitis.
authors: Department of Radiology, Gyeongsang National University School of medicine, 79 Gangnam-ro, Jinju, 52727, Republic of Korea.
authors: Ji Eun
authors: JE
authors: Kim
authors: Department of Radiology, Gyeongsang National University School of medicine, 79 Gangnam-ro, Jinju, 52727, Republic of Korea. choids@gnu.ac.kr.
authors: Dae Seob
authors: DS
authors: Choi
authors: Department of Radiology, Gyeongsang National University School of medicine, 79 Gangnam-ro, Jinju, 52727, Republic of Korea.
authors: Kyungsoo
authors: K
authors: Bae
authors: Department of Radiology, Gyeongsang National University School of medicine, 79 Gangnam-ro, Jinju, 52727, Republic of Korea.
authors: Jae Min
authors: JM
authors: Cho
authors: Department of Surgery, Gyeongsang National University School of medicine, Jinju, Republic of Korea.
authors: Chi Young
authors: CY
authors: Jeong
authors: Department of Internal medicine, Gyeongsang National University School of medicine, Jinju, Republic of Korea.
authors: Hyun Ok
authors: HO
authors: Kim
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D041881:Cholecystitis, Acute / Q000000981:diagnostic imaging*; D054459:Elasticity Imaging Techniques / Q000379:methods*; D005260:Female; D006801:Humans; D008099:Liver / Q000000981:diagnostic imaging; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012372:ROC Curve; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D055815:Young Adult
keywords: Cholecystitis, Acute; Diagnosis; Elasticity Imaging Techniques; Gallbladder; Ultrasound