title: [Not Available].
abstract: Metastatic process is described as a "dissemination of neoplastic cells in a distant secondary site, in which cells proliferate to develop a mass of cells partially differentiated". The vast majority of death in solid cancers is the consequence of metastasis development which lead to vital organ dysfunction. In the present review, either recent discoveries or controversial subjects associated with metastasis process will be discussed. Indeed epithelia-mesenchymal transition (EMT), circulating tumor cells, tumor dormancy, colonization in distant organ and cancer stem cells are tackled.
authors: UMR 5203, Inserm U1191, Université Montpellier, Institut de Génomique Fonctionnelle, Montpellier, France.
authors: Jean-Marc
authors: JM
authors: Pascussi
authors: UMR 5203, Inserm U1191, Université Montpellier, Institut de Génomique Fonctionnelle, Montpellier, France.
authors: Julie
authors: J
authors: Giraud
authors: Institut Régional du Cancer de Montpellier (ICM), Val d'Aurelle, Montpellier, France.
authors: Emmanuelle
authors: E
authors: Samalin
authors: UMR 5203, Inserm U1191, Université Montpellier, Institut de Génomique Fonctionnelle, Montpellier, France.
authors: Fanny
authors: F
authors: Grillet
authors: UMR 5203, Inserm U1191, Université Montpellier, Institut de Génomique Fonctionnelle, Montpellier, France. Electronic address: julie.pannequin@igf.cnrs.fr.
authors: Julie
authors: J
authors: Pannequin
mesh_terms: D002448:Cell Adhesion; D002465:Cell Movement; D058750:Epithelial-Mesenchymal Transition; D006801:Humans; D009361:Neoplasm Invasiveness; D009362:Neoplasm Metastasis / Q000473:pathology / Q000503:physiopathology; D009360:Neoplastic Cells, Circulating / Q000473:pathology; D014411:Neoplastic Stem Cells / Q000502:physiology; D009928:Organ Specificity; D059016:Tumor Microenvironment
keywords: Cellules tumorales circulantes et cellules souches cancéreuses; Circulating tumor cells and cancer stem cells; Epithelia-mesenchymal transition; Metastasis; Métastase; Transition épithélio-mesenchymateuse