title: In vitro evaluation of a newly produced resin-based endodontic sealer.
abstract: OBJECTIVE
  A variety of root canal sealers were recently launched to the market. This study evaluated physicochemical properties, biocompatibility, and sealing ability of a newly launched resin-based sealer (Dia-Proseal, Diadent) compared to the existing root canal sealers (AHplus, Dentsply DeTrey and ADseal, Metabiomed).
  
  
  METHODS
  The physicochemical properties of the tested sealers including pH, solubility, dimensional change, and radiopacity were evaluated. Biocompatibility was measured using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. For microleakage test, single-rooted teeth were instrumented, and obturated with gutta-percha and one of the sealers (n = 10). After immersion in 1% methylene blue solution for 2 weeks, the specimens were split longitudinally. Then, the maximum length of staining was measured. Statistical analysis was performed by one-way analysis of variance followed by Tukey test (p = 0.05).
  
  
  RESULTS
  Dia-Proseal showed the highest pH value among the tested sealers (p < 0.05). ADseal showed higher dimensional change compared to AHplus and Dia-Proseal (p < 0.05). The solubility values of AHplus and Dia-Proseal were similar, whereas ADseal had the lowest solubility value (p < 0.05). The flow values of sealer in increasing order were AHplus, DiaProseal, and ADseal (p < 0.05). The radiopacity of AHplus was higher than those of ADseal and Dia-Proseal (p < 0.05). The cell viability of the tested materials was statistically similar throughout the experimental period. There were no significant differences in microleakage values among the tested samples.
  
  
  CONCLUSIONS
  The present study indicates that Dia-Proseal has acceptable physicochemical properties, biocompatibility, and sealing ability.
authors: Department of Conservative Dentistry, School of Dentistry and Institute of Oral Bioscience, Chonbuk National University, Jeonju, Korea.
authors: Yoo-Seok
authors: YS
authors: Song
authors: Department of Conservative Dentistry, Wonkwang University Dental Hospital, Iksan, Korea.
authors: Yoorina
authors: Y
authors: Choi
authors: Department of Conservative Dentistry, School of Dentistry and Institute of Oral Bioscience, Chonbuk National University, Jeonju, Korea.
authors: Myung-Jin
authors: MJ
authors: Lim
authors: Department of Conservative Dentistry, School of Dentistry and Institute of Oral Bioscience, Chonbuk National University, Jeonju, Korea.; Biomedical Research Institute of Chonbuk National University Hospital, Jeonju, Korea.
authors: Mi-Kyung
authors: MK
authors: Yu
authors: Department of Conservative Dentistry, School of Dentistry, Dankook University, Cheonan, Korea.
authors: Chan-Ui
authors: CU
authors: Hong
authors: Department of Conservative Dentistry, School of Dentistry and Institute of Oral Bioscience, Chonbuk National University, Jeonju, Korea.; Biomedical Research Institute of Chonbuk National University Hospital, Jeonju, Korea.
authors: Kwang-Won
authors: KW
authors: Lee
authors: Department of Conservative Dentistry, School of Dentistry and Institute of Oral Bioscience, Chonbuk National University, Jeonju, Korea.; Biomedical Research Institute of Chonbuk National University Hospital, Jeonju, Korea.
authors: Kyung-San
authors: 0000-0002-1928-3384
authors: KS
authors: Min
keywords: Biocompatibility; Microleakage; Physicochemical; Sealer