title: Nucleophilic Difluoromethylenation of Ketones Using Diethyl (Difluoro(trimethylsilyl)methyl)phosphonate Mediated by 18-Crown-6 Ether/KOAc.
abstract: We report a general difluoromethylenation of various types of ketones using diethyl (difluoro(trimethylsilyl)methyl)phosphonate mediated by the combination of 18-crown-6 and KOAc. It provides facile access to structurally diverse β-hydroxy-α,α-difluorophosphonates as interesting targets for medicinal research.
authors: Shanghai Key Laboratory of Green Chemistry and Chemical Process, School of Chemistry and Molecular Engineering, East China Normal University , 3663 N. Zhongshan Road, Shanghai 200062, P. R. China.
authors: Yu-Hui
authors: YH
authors: Wang
authors: Shanghai Key Laboratory of Green Chemistry and Chemical Process, School of Chemistry and Molecular Engineering, East China Normal University , 3663 N. Zhongshan Road, Shanghai 200062, P. R. China.
authors: Zhong-Yan
authors: ZY
authors: Cao
authors: Shanghai Key Laboratory of Green Chemistry and Chemical Process, School of Chemistry and Molecular Engineering, East China Normal University , 3663 N. Zhongshan Road, Shanghai 200062, P. R. China.|State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences , Shanghai 200032, P. R. China.
authors: Jian
authors: J
authors: Zhou