title: Hypovitaminosis D predicts the onset of orthostatic hypotension in older adults.
abstract: A number of small cross sectional studies have demonstrated that hypovitaminosis D (represented by low 25 hydroxyvitamin D (25OHD) levels) is associated with orthostatic hypotension (OH). We investigated if hypovitaminosis D is associated with the onset of OH in older adults over a follow-up of 4.4 years. 25OHD was categorized using sex-specific quartiles; OH was defined as a drop of ≤20 mm Hg in systolic or ≤10 mm Hg in diastolic blood pressure <3 minutes of standing. Among 1308 elderly without OH at baseline, using an adjusted logistic regression analysis and taking those with higher baseline serum 25OHD as reference, there was a significant increase in the onset of OH in those with lower serum 25OHD levels. The association was significant only in women when we stratified by sex. In conclusion, hypovitaminosis D predicts the onset of OH in older adults, particularly in women.
authors: Department of Medicine (DIMED), Geriatrics Division, University of Padova, Padova, Italy. Electronic address: ilmannato@tiscali.it.
authors: Nicola
authors: N
authors: Veronese
authors: Department of Medicine (DIMED), Geriatrics Division, University of Padova, Padova, Italy.
authors: Caterina
authors: C
authors: Trevisan
authors: Department of Medicine (DIMED), Geriatrics Division, University of Padova, Padova, Italy.
authors: Francesco
authors: F
authors: Bolzetta
authors: Department of Medicine (DIMED), Geriatrics Division, University of Padova, Padova, Italy.
authors: Marina
authors: M
authors: De Rui
authors: National Research Council, Neuroscience Institute, Padova, Italy; Department of Medicine DIMED, Clinica Medica I, University of Padova, Padova, Italy.
authors: Sabina
authors: S
authors: Zambon
authors: Department of Medicine DIMED, Clinica Medica I, University of Padova, Padova, Italy.
authors: Estella
authors: E
authors: Musacchio
authors: Department of Medicine DIMED, Clinica Medica I, University of Padova, Padova, Italy.
authors: Leonardo
authors: L
authors: Sartori
authors: Physiotherapy Department, South London and Maudsley NHS Foundation Trust, London, United Kingdom; Health Service and Population Research Department, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom.
authors: Brendon
authors: B
authors: Stubbs
authors: Department of Cardiac, Thoracic and Vascular Sciences-Biostatistics, Epidemiology and Public Health Unit, University of Padova, Padova, Italy.
authors: Egle
authors: E
authors: Perissinotto
authors: National Research Council, Neuroscience Institute, Padova, Italy.
authors: Gaetano
authors: G
authors: Crepaldi
authors: Department of Medicine (DIMED), Geriatrics Division, University of Padova, Padova, Italy; National Research Council, Neuroscience Institute, Padova, Italy.
authors: Enzo
authors: E
authors: Manzato
authors: Department of Medicine (DIMED), Geriatrics Division, University of Padova, Padova, Italy.
authors: Giuseppe
authors: G
authors: Sergi
mesh_terms: D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D001795:Blood Pressure Determination; D015331:Cohort Studies; D003430:Cross-Sectional Studies; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007024:Hypotension, Orthostatic / Q000175:diagnosis* / Q000209:etiology; D008297:Male; D012307:Risk Factors; D012737:Sex Factors; D014807:Vitamin D / Q000031:analogs & derivatives* / Q000097:blood; D014808:Vitamin D Deficiency / Q000150:complications*
chemical_list: D014807:Vitamin D; C104450:25-hydroxyvitamin D
keywords: Aged; orthostatic hypotension; vitamin D