title: Maternal Exposure to Occupational Asthmagens During Pregnancy and Autism Spectrum Disorder in the Study to Explore Early Development.
abstract: Maternal immune activity has been linked to children with autism spectrum disorder (ASD). We examined maternal occupational exposure to asthma-causing agents during pregnancy in relation to ASD risk. Our sample included 463 ASD cases and 710 general population controls from the Study to Explore Early Development whose mothers reported at least one job during pregnancy. Asthmagen exposure was estimated from a published job-exposure matrix. The adjusted odds ratio for ASD comparing asthmagen-exposed to unexposed was 1.39 (95 % CI 0.96-2.02). Maternal workplace asthmagen exposure was not associated with ASD risk in this study, but this result does not exclude some involvement of maternal exposure to asthma-causing agents in ASD.
authors: Department of Epidemiology and Wendy Klag Center for Autism and Developmental Disabilities, Johns Hopkins University Bloomberg School of Public Health, 615 N. Wolfe St., Baltimore, MD, 21205, USA. alison_singer@unc.edu.|Department of Epidemiology, University of North Carolina Gillings School of Global Public Health, Chapel Hill, NC, USA. alison_singer@unc.edu.
authors: Alison B
authors: 0000-0002-8907-6620
authors: AB
authors: Singer
authors: Division of Environmental and Occupational Disease, California Department of Public Health, Richmond, CA, USA.
authors: Gayle C
authors: GC
authors: Windham
authors: Division of Research, Kaiser Permanente Northern California, Oakland, CA, USA.
authors: Lisa A
authors: LA
authors: Croen
authors: Department of Epidemiology, University of North Carolina Gillings School of Global Public Health, Chapel Hill, NC, USA.
authors: Julie L
authors: JL
authors: Daniels
authors: Department of Epidemiology and Biostatistics and the A.J. Drexel Autism Institute, Drexel University Dornsife School of Public Health, Philadelphia, PA, USA.
authors: Brian K
authors: BK
authors: Lee
authors: Division of Research, Kaiser Permanente Northern California, Oakland, CA, USA.
authors: Yinge
authors: Y
authors: Qian
authors: Department of Public Health, Section for Epidemiology, Aarhus University, Aarhus, Denmark.|Department of Economics and Business, National Centre for Register-based Research, Aarhus University, Aarhus, Denmark.|Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Aarhus, Denmark.
authors: Diana E
authors: DE
authors: Schendel
authors: Department of Epidemiology and Wendy Klag Center for Autism and Developmental Disabilities, Johns Hopkins University Bloomberg School of Public Health, 615 N. Wolfe St., Baltimore, MD, 21205, USA.|Department of Mental Health and the Wendy Klag Center for Autism and Developmental Disabilities, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, USA.
authors: M Daniele
authors: MD
authors: Fallin
authors: Department of Epidemiology and Biostatistics and the A.J. Drexel Autism Institute, Drexel University Dornsife School of Public Health, Philadelphia, PA, USA.|Department of Environmental and Occupational Health and the A.J. Drexel Autism Institute, Drexel University Dornsife School of Public Health, Philadelphia, PA, USA.
authors: Igor
authors: I
authors: Burstyn
mesh_terms: D000328:Adult; D000395:Air Pollutants, Occupational / Q000009:adverse effects* / Q000276:immunology*; D000704:Analysis of Variance; D059366:Asthma, Occupational / Q000276:immunology*; D000067877:Autism Spectrum Disorder / Q000276:immunology*; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D008607:Intellectual Disability / Q000276:immunology; D008297:Male; D018811:Maternal Exposure / Q000009:adverse effects*; D016273:Occupational Exposure / Q000009:adverse effects*; D016017:Odds Ratio; D011247:Pregnancy; D011248:Pregnancy Complications / Q000276:immunology*; D012307:Risk Factors
chemical_list: D000395:Air Pollutants, Occupational
keywords: Allergy; Asthma; Autism; Exposure; Maternal; Maternal occupation