title: First Report of the Globally Disseminated IncX4 Plasmid Carrying the mcr-1 Gene in a Colistin-Resistant Escherichia coli Sequence Type 101 Isolate from a Human Infection in Brazil.
abstract: A colistin-resistant Escherichia coli strain was recovered from a patient with a diabetic foot infection in Brazil. Whole-genome analysis revealed that the E. coli isolate belonged to the widespread sequence type (ST) 101 and harbored the mcr-1 gene on an IncX4 plasmid that was highly similar to mcr-1-bearing IncX4 plasmids that were recently identified in Enterobacteriaceae from food, animal, and human samples recovered on different continents. These results suggest that self-transmissible IncX4-type plasmids may represent promiscuous plasmids contributing to the intercontinental spread of the mcr-1 gene.
authors: Department of Clinical Analysis, Faculty of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil miriamrfernandes@usp.br lincopan@usp.br.
authors: Miriam R
authors: MR
authors: Fernandes
authors: Department of Clinical Analysis, Faculty of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil.
authors: John A
authors: JA
authors: McCulloch
authors: Hospital de Guarnição de Natal, Brazilian Army, Natal, Brazil.
authors: Marco A
authors: MA
authors: Vianello
authors: Department of Microbiology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.
authors: Quézia
authors: Q
authors: Moura
authors: Department of Clinical Analysis, Faculty of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil.
authors: Paula J
authors: PJ
authors: Pérez-Chaparro
authors: Department of Clinical Analysis, Faculty of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil.
authors: Fernanda
authors: F
authors: Esposito
authors: Department of Clinical Analysis, Faculty of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil.
authors: Luciana
authors: L
authors: Sartori
authors: School of Public Health, University of São Paulo, São Paulo, Brazil.
authors: Milena
authors: M
authors: Dropa
authors: School of Public Health, University of São Paulo, São Paulo, Brazil.
authors: Maria H
authors: MH
authors: Matté
authors: Hospital de Guarnição de Natal, Brazilian Army, Natal, Brazil.
authors: Débora P A
authors: DP
authors: Lira
authors: Department of Clinical Analysis, Faculty of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil.
authors: Elsa M
authors: EM
authors: Mamizuka
authors: Department of Clinical Analysis, Faculty of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil Department of Microbiology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil miriamrfernandes@usp.br lincopan@usp.br.
authors: Nilton
authors: 0000-0003-0161-5800
authors: N
authors: Lincopan
mesh_terms: D000368:Aged; D001938:Brazil; D003091:Colistin / Q000494:pharmacology*; D024881:Drug Resistance, Bacterial / Q000187:drug effects / Q000235:genetics*; D004926:Escherichia coli / Q000187:drug effects* / Q000235:genetics / Q000302:isolation & purification*; D004927:Escherichia coli Infections / Q000188:drug therapy / Q000382:microbiology; D029968:Escherichia coli Proteins / Q000235:genetics*; D006801:Humans; D008297:Male; D008826:Microbial Sensitivity Tests; D010957:Plasmids / Q000187:drug effects / Q000235:genetics
chemical_list: D029968:Escherichia coli Proteins; C000614037:MCR-1 protein, E coli; D003091:Colistin