title: Antioxidative Theranostic Iron Oxide Nanoparticles toward Brain Tumors Imaging and ROS Production.
abstract: Gliomas are the most common primary brain tumor in humans. To date, the only treatment of care consists of surgical removal of the tumor bulk, irradiation, and chemotherapy, finally resulting in a very poor prognosis due to the lack of efficiency in diagnostics. In this context, nanomedicine combining both diagnostic and magnetic resonance imaging (MRI) and therapeutic applications is a relevant strategy referred to theranostic. Magnetic nanoparticles (NP) are excellent MRI contrast agents because of their large magnetic moment, which induces high transverse relaxivity (r2) characteristic and increased susceptibility effect (T2*). NP can be also used for drug delivery by coating their surface with therapeutic molecules. Preliminary in vitro studies show the high potential of caffeic acid (CA), a natural polyphenol, as a promising anticancer drug due to its antioxidant, anti-inflammatory, and antimetastatic properties. In this study, the antioxidative properties of iron oxide NP functionalized with caffeic acid (γFe2O3@CA NP) are investigated in vitro on U87-MG brain cancer cell lines. After intravenous injection of these NP in mice bearing a U87 glioblastoma, a negative contrast enhancement was specifically observed on 11.7 T MRI images in cancerous tissue, demonstrating a passive targeting of the tumor with these nanoplatforms.
authors: Laboratoire CSPBAT, CNRS UMR 7244 UFR SMBH, Université Paris 13 Sorbonne Paris Cité, F-93017 Bobigny, France.
authors: Sophie
authors: S
authors: Richard
authors: Laboratoire de Toxicologie, Pharmacologie et Signalisation Cellulaire, INSERM U1124, Université Paris-Descartes, Centre Universitaire des Saints-Pères , F-75270 Paris Cedex 06, France.|Division of Molecular Medicine, Rudger Boskivic Institute , Zagreb, Croatia.
authors: Ana
authors: A
authors: Saric
authors: Unité d'Imagerie par Résonance Magnétique et de Spectroscopie, CEA/DRF/I2BM/NeuroSpin, F-91191 Gif-sur-Yvette, France.
authors: Marianne
authors: M
authors: Boucher
authors: Inserm, U100, Laboratoire de Physiologie Cellulaire, Université Lille 1 , F-59655 Villeneuve d'Ascq, France.
authors: Christian
authors: C
authors: Slomianny
authors: Unité d'Imagerie par Résonance Magnétique et de Spectroscopie, CEA/DRF/I2BM/NeuroSpin, F-91191 Gif-sur-Yvette, France.
authors: Françoise
authors: F
authors: Geffroy
authors: Unité d'Imagerie par Résonance Magnétique et de Spectroscopie, CEA/DRF/I2BM/NeuroSpin, F-91191 Gif-sur-Yvette, France.
authors: Sébastien
authors: S
authors: Mériaux
authors: Inserm, U1148, Laboratory for Vascular Translational Science, UFR SMBH, Université Paris 13 , Sorbonne Paris Cité, F-93017 Bobigny, France.|Service de Médecine Nucléaire, Hôpital Avicenne Assistance Publique-Hôpitaux de Paris, F-93009 Bobigny, France.
authors: Yoann
authors: Y
authors: Lalatonne
authors: Laboratoire de Toxicologie, Pharmacologie et Signalisation Cellulaire, INSERM U1124, Université Paris-Descartes, Centre Universitaire des Saints-Pères , F-75270 Paris Cedex 06, France.
authors: Patrice X
authors: PX
authors: Petit
authors: Inserm, U1148, Laboratory for Vascular Translational Science, UFR SMBH, Université Paris 13 , Sorbonne Paris Cité, F-93017 Bobigny, France.
authors: Laurence
authors: L
authors: Motte
mesh_terms: D000975:Antioxidants / Q000494:pharmacology*; D001932:Brain Neoplasms / Q000000981:diagnostic imaging* / Q000378:metabolism*; D045744:Cell Line, Tumor; D005290:Ferric Compounds / Q000008:administration & dosage*; D006801:Humans; D008279:Magnetic Resonance Imaging; D053768:Metal Nanoparticles; D046529:Microscopy, Electron, Transmission; D017382:Reactive Oxygen Species / Q000378:metabolism*; D000068936:Theranostic Nanomedicine
chemical_list: D000975:Antioxidants; D005290:Ferric Compounds; D017382:Reactive Oxygen Species; C000499:ferric oxide