title: AdoMet analog synthesis and utilization: current state of the art.
abstract: S-Adenosyl-l-methionine (AdoMet) is an essential enzyme cosubstrate in fundamental biology with an expanding range of biocatalytic and therapeutic applications. In recent years, technologies enabling the synthesis and utilization of novel functional AdoMet surrogates have rapidly advanced. Developments highlighted within this brief review include improved syntheses of AdoMet analogs, unique S-adenosyl-l-methionine isosteres with enhanced stability, and corresponding applications in epigenetics, proteomics and natural product/small molecule diversification ('alkylrandomization').
authors: Center for Pharmaceutical Research and Innovation, College of Pharmacy, University of Kentucky, 789 South Limestone Street, Lexington, KY 40536, United States; Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, United States.
authors: Tyler D
authors: TD
authors: Huber
authors: Center for Pharmaceutical Research and Innovation, College of Pharmacy, University of Kentucky, 789 South Limestone Street, Lexington, KY 40536, United States; Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, United States.
authors: Brooke R
authors: BR
authors: Johnson
authors: Center for Pharmaceutical Research and Innovation, College of Pharmacy, University of Kentucky, 789 South Limestone Street, Lexington, KY 40536, United States; Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, United States.
authors: Jianjun
authors: J
authors: Zhang
authors: Center for Pharmaceutical Research and Innovation, College of Pharmacy, University of Kentucky, 789 South Limestone Street, Lexington, KY 40536, United States; Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, United States. Electronic address: jsthorson@uky.edu.
authors: Jon S
authors: JS
authors: Thorson
mesh_terms: D000818:Animals; D055162:Biocatalysis; D002384:Catalysis; D006801:Humans; D007700:Kinetics; D060847:Metabolic Engineering / Q000379:methods / Q000639:trends; D008715:Methionine / Q000031:analogs & derivatives; D012436:S-Adenosylmethionine / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000494:pharmacology*; D013379:Substrate Specificity; D058615:Synthetic Biology / Q000379:methods / Q000639:trends*
chemical_list: D012436:S-Adenosylmethionine; D008715:Methionine