title: Multiparametric Genomic Assays for Breast Cancer: Time for the Next Generation?
abstract: The Breast Cancer Index appears to perform better than the 21-gene recurrence score in predicting 10-year disease-free survival in postmenopausal women with hormone receptor-positive lymph node-negative early-stage breast cancer. This may have implications for clinical use of first-generation versus second-generation multiparametric genomic assays. Clin Cancer Res; 22(20); 4963-5. ©2016 AACRSee related article by Sestak et al., p. 5043.
authors: Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania. University of Pittsburgh Cancer Institute, University of Pittsburgh, Pittsburgh, Pennsylvania.
authors: Adam M
authors: AM
authors: Brufsky
authors: Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania. University of Pittsburgh Cancer Institute, University of Pittsburgh, Pittsburgh, Pennsylvania. davidsonne@upmc.edu.
authors: Nancy E
authors: NE
authors: Davidson
mesh_terms: D000077384:Anastrozole; D018931:Antineoplastic Agents, Hormonal / Q000627:therapeutic use*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001681:Biological Assay / Q000379:methods*; D001943:Breast Neoplasms / Q000188:drug therapy / Q000235:genetics / Q000401:mortality; D018572:Disease-Free Survival; D005260:Female; D018398:Homeodomain Proteins / Q000235:genetics; D006801:Humans; D009570:Nitriles / Q000627:therapeutic use*; D017698:Postmenopause; D011379:Prognosis; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000378:metabolism; D011960:Receptors, Estrogen / Q000378:metabolism; D053722:Receptors, Interleukin-17 / Q000235:genetics; D011980:Receptors, Progesterone / Q000378:metabolism; D013629:Tamoxifen / Q000627:therapeutic use*; D014230:Triazoles / Q000627:therapeutic use*
chemical_list: D000077384:Anastrozole; D018931:Antineoplastic Agents, Hormonal; D018398:Homeodomain Proteins; D009570:Nitriles; D018719:Erb-b2 Receptor Tyrosine Kinases; D011960:Receptors, Estrogen; D053722:Receptors, Interleukin-17; D011980:Receptors, Progesterone; D013629:Tamoxifen; D014230:Triazoles; C484414:HOXB13 protein, human; C109985:IL17RA protein, human; C508053:ERBB2 protein, human