title: Elevated cholesterol levels have a poor prognosis in a cholestasis scenario.
abstract: Cholestasis results from defective bile flow through the biliary ducts leading to the accumulation of bile acids (BAs) in hepatocytes and serum. It has been seen that cholestasis is associated with hypercholesterolemia, which is a prerequisite for gallstone formation and primary biliary cirrhosis, being some of the most common gastrointestinal disorders in Western societies. Cytotoxic BAs induce proinflammatory mediators, oxidative stress, and apoptosis in hepatocytes, whereas cytoprotective BAs prevent them; they can also modify the plasmatic membrane structure of cells or mitochondrial outer membrane properties as well as the distribution of cholesterol, altering various proteins involved in BAs homeostasis.
authors: Traslational Research Unit, Médica Sur Clinic & Foundation, Toriello guerra tlalpan, C.P. 14050, Mexico City, Mexico.
authors: Natalia
authors: N
authors: Nuño-Lámbarri
authors: Traslational Research Unit, Médica Sur Clinic & Foundation, Toriello guerra tlalpan, C.P. 14050, Mexico City, Mexico.
authors: Varenka J
authors: VJ
authors: Barbero-Becerra
authors: Obesity and Digestive Diseases Unit, Médica Sur Clinic & Foundation, Toriello guerra tlalpan, C.P. 14050, Mexico City, Mexico.
authors: Misael
authors: M
authors: Uribe
authors: Traslational Research Unit, Médica Sur Clinic & Foundation, Toriello guerra tlalpan, C.P. 14050, Mexico City, Mexico.|Obesity and Digestive Diseases Unit, Médica Sur Clinic & Foundation, Toriello guerra tlalpan, C.P. 14050, Mexico City, Mexico.
authors: Norberto C
authors: NC
authors: Chávez-Tapia
mesh_terms: D017209:Apoptosis; D001647:Bile Acids and Salts / Q000097:blood; D002462:Cell Membrane / Q000378:metabolism / Q000473:pathology; D002779:Cholestasis / Q000097:blood* / Q000175:diagnosis / Q000209:etiology / Q000473:pathology; D002784:Cholesterol / Q000097:blood*; D022781:Hepatocytes / Q000378:metabolism / Q000473:pathology; D006801:Humans; D006937:Hypercholesterolemia / Q000097:blood* / Q000150:complications / Q000175:diagnosis / Q000473:pathology; D018836:Inflammation Mediators / Q000097:blood; D008930:Mitochondria, Liver / Q000378:metabolism / Q000473:pathology; D051336:Mitochondrial Membranes / Q000378:metabolism / Q000473:pathology; D018384:Oxidative Stress; D011379:Prognosis
chemical_list: D001647:Bile Acids and Salts; D018836:Inflammation Mediators; D002784:Cholesterol
keywords: bile acids; cholestasis; cholesterol