title: Core Concepts Involving Adverse Psychotropic Drug Effects: Assessment, Implications, and Management.
abstract: Adverse effects from psychiatric drugs can profoundly influence treatment adherence and outcomes. Good care involves addressing adverse effects no differently than any other component of treatment. Knowledge about adverse effect assessment and management fosters a proper context that helps clinicians not sacrifice a drug's potential therapeutic benefits because of greater concerns about its tolerability. This article provides an overview of basic concepts related to the assessment and management of suspected adverse effects from psychotropic drugs. Key points are discussed regarding clinical, pharmacogenetic, pharmacokinetic, and pharmacodynamic risk factors for treatment-emergent adverse effects, alongside recommendations for their systematic assessment.
authors: Department of Psychiatry, Icahn School of Medicine at Mount Sinai, Gustave L. Levy Place, Box 1230, New York, NY 10029, USA. Electronic address: joseph.goldberg@mssm.edu.
authors: Joseph F
authors: JF
authors: Goldberg
authors: Department of Psychiatry, Icahn School of Medicine at Mount Sinai, Gustave L. Levy Place, Box 1230, New York, NY 10029, USA; Department of Medical Education, Icahn School of Medicine at Mount Sinai, Gustave L. Levy Place, Box 1230, New York, NY 10029, USA.
authors: Carrie L
authors: CL
authors: Ernst
mesh_terms: D064420:Drug-Related Side Effects and Adverse Reactions / Q000175:diagnosis / Q000209:etiology / Q000235:genetics / Q000628:therapy; D006801:Humans; D011619:Psychotropic Drugs / Q000009:adverse effects*
chemical_list: D011619:Psychotropic Drugs
keywords: Adverse effects; Adverse event; Drug safety; Drug tolerability; Iatrogenic; Nocebo; Pharmacogenetics