title: Regulatory Roles of Fluctuation-Driven Mechanotransduction in Cell Function.
abstract: Cells in the body are exposed to irregular mechanical stimuli. Here, we review the so-called fluctuation-driven mechanotransduction in which stresses stretching cells vary on a cycle-by-cycle basis. We argue that such mechanotransduction is an emergent network phenomenon and offer several potential mechanisms of how it regulates cell function. Several examples from the vasculature, the lung, and tissue engineering are discussed. We conclude with a list of important open questions.
authors: Department of Biomedical Engineering, Boston University, Boston, Massachusetts bsuki@bu.edu.
authors: Béla
authors: B
authors: Suki
authors: Department of Biomedical Engineering, Boston University, Boston, Massachusetts.
authors: Harikrishnan
authors: H
authors: Parameswaran
authors: Department of Biomedical Engineering, Boston University, Boston, Massachusetts.
authors: Jasmin
authors: J
authors: Imsirovic
authors: Department of Biomedical Engineering, Boston University, Boston, Massachusetts.
authors: Erzsébet
authors: E
authors: Bartolák-Suki
mesh_terms: D000818:Animals; D002320:Cardiovascular Physiological Phenomena; D002448:Cell Adhesion; D040542:Mechanotransduction, Cellular; D051379:Mice; D008954:Models, Biological; D009119:Muscle Contraction; D009131:Muscle, Smooth, Vascular / Q000378:metabolism / Q000502:physiology*; D015398:Signal Transduction; D013312:Stress, Physiological