title: Microchemical Pen: An Open Microreactor for Region-Selective Surface Modification.
abstract: Various micro surface-modification approaches including photolithography, dip-pen lithography and ink-jet systems have been developed and used to extend the functionalities of solid surfaces. While those approaches work in the "open space", push-pull systems which work in solutions have recently drawn considerable attention. However, the confining flows performed by push-pull systems have realized only the dispense process, while microscale, region-selective chemical reactions have remained unattainable. This study reports a microchemical pen that enables region-selective chemical reactions for the micro surface modification/patterning. The chemical pen is based on the principle of microfluidic laminar flows and the resulting mixing of reagents by the mutual diffusion. The tiny diffusion layer performs as the working region. This report represents the first demonstration of an open microreactor in which two different reagents react on a real solid sample. The multifunctional characteristics of the microchemical pen are confirmed by different types of reactions in many research areas, including inorganic chemistry, polymer science, electrochemistry and biological sample treatment.
authors: Department of Applied Chemistry, Graduate School of Urban Environmental Sciences, Tokyo Metropolitan University, Minamiohsawa, Hachioji, Tokyo, 192-0397, Japan.
authors: Sifeng
authors: S
authors: Mao
authors: Department of Applied Chemistry, Graduate School of Urban Environmental Sciences, Tokyo Metropolitan University, Minamiohsawa, Hachioji, Tokyo, 192-0397, Japan.
authors: Chiho
authors: C
authors: Sato
authors: Department of Human Mechatronics Systems, Graduate School of System Design, Tokyo Metropolitan University, Hino-shi, Tokyo, 191-0065, Japan.
authors: Yuma
authors: Y
authors: Suzuki
authors: Department of Applied Chemistry, Graduate School of Urban Environmental Sciences, Tokyo Metropolitan University, Minamiohsawa, Hachioji, Tokyo, 192-0397, Japan.
authors: Jianmin
authors: J
authors: Yang
authors: Department of Applied Chemistry, Graduate School of Urban Environmental Sciences, Tokyo Metropolitan University, Minamiohsawa, Hachioji, Tokyo, 192-0397, Japan.
authors: Hulie
authors: H
authors: Zeng
authors: Department of Applied Chemistry, Graduate School of Urban Environmental Sciences, Tokyo Metropolitan University, Minamiohsawa, Hachioji, Tokyo, 192-0397, Japan.
authors: Hizuru
authors: H
authors: Nakajima
authors: Department of Human Mechatronics Systems, Graduate School of System Design, Tokyo Metropolitan University, Hino-shi, Tokyo, 191-0065, Japan.
authors: Ming
authors: M
authors: Yang
authors: Department of Chemistry, Tsinghua University, Beijing, 100084, China.
authors: Jin-Ming
authors: JM
authors: Lin
authors: Department of Applied Chemistry, Graduate School of Urban Environmental Sciences, Tokyo Metropolitan University, Minamiohsawa, Hachioji, Tokyo, 192-0397, Japan. uchiyama-katsumi@tmu.ac.jp.
authors: Katsumi
authors: K
authors: Uchiyama
mesh_terms: D004058:Diffusion; D046210:Microfluidic Analytical Techniques / Q000295:instrumentation; D011327:Printing / Q000295:instrumentation; D013499:Surface Properties
keywords: laminar flow; microchemical pen; microfluidics; microreactors; region-selective surface modification