title: Antenatal immunoglobulin for prevention of neonatal hemochromatosis.
abstract: Neonatal hemochromatosis (NH) is a rare disease with a poor prognosis, particularly prior to 2008. Antenatal maternal high-dose immunoglobulin (Ig) is effective in preventing NH recurrence, but the adverse effects of this treatment have not been documented as yet. Here, we report on a patient who underwent high-dose Ig treatment to prevent NH recurrence. The patient was a 31-year-old pregnant Japanese woman. Her first child died of NH after receiving living donor liver transplantation. The patient received high-dose Ig treatment to prevent recurrence of NH from gestational weeks 16 to 35. During the treatment, platelet count gradually decreased, and cesarean section was required at 35 gestational weeks. The child did not develop liver failure. High-dose Ig prevented the recurrence of NH. Caution should be exercised due to possible adverse effects of this treatment.
authors: Department of Transplant Surgery, Jichi Medical University, Shimotsuke, Tochigi, Japan. r0906no@jichi.ac.jp.
authors: Noriki
authors: N
authors: Okada
authors: Department of Transplant Surgery, Jichi Medical University, Shimotsuke, Tochigi, Japan.
authors: Yoshiyuki
authors: Y
authors: Ihara
authors: Department of Transplant Surgery, Jichi Medical University, Shimotsuke, Tochigi, Japan.
authors: Taizen
authors: T
authors: Urahashi
authors: Department of Transplant Surgery, Jichi Medical University, Shimotsuke, Tochigi, Japan.
authors: Yukihiro
authors: Y
authors: Sanada
authors: Department of Transplant Surgery, Jichi Medical University, Shimotsuke, Tochigi, Japan.
authors: Naoya
authors: N
authors: Yamada
authors: Department of Transplant Surgery, Jichi Medical University, Shimotsuke, Tochigi, Japan.
authors: Yuta
authors: Y
authors: Hirata
authors: Department of Transplant Surgery, Jichi Medical University, Shimotsuke, Tochigi, Japan.
authors: Masahisa
authors: M
authors: Tashiro
authors: Department of Transplant Surgery, Jichi Medical University, Shimotsuke, Tochigi, Japan.
authors: Takumi
authors: T
authors: Katano
authors: Department of Pharmacy, Jichi Medical University, Shimotsuke, Tochigi, Japan.
authors: Kentaro
authors: K
authors: Ushijima
authors: Department of Clinical Pharmacy, Jichi Medical University, Shimotsuke, Tochigi, Japan.
authors: Shinya
authors: S
authors: Otomo
authors: Department of Obstetrics and Gynecology, Jichi Medical University, Shimotsuke, Tochigi, Japan.
authors: Hironori
authors: H
authors: Takahashi
authors: Department of Obstetrics and Gynecology, Jichi Medical University, Shimotsuke, Tochigi, Japan.
authors: Shigeki
authors: S
authors: Matsubara
authors: Department of Transplant Surgery, Jichi Medical University, Shimotsuke, Tochigi, Japan.
authors: Koichi
authors: K
authors: Mizuta
mesh_terms: D000328:Adult; D005260:Female; D006432:Hemochromatosis / Q000196:embryology / Q000517:prevention & control*; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use*; D007231:Infant, Newborn; D008279:Magnetic Resonance Imaging; D011247:Pregnancy; D011295:Prenatal Care / Q000379:methods*; D011296:Prenatal Diagnosis
chemical_list: D016756:Immunoglobulins, Intravenous
keywords: high-dose immunogloblin; neonatal hemochromatosis