title: Efficacy of fluralaner in 17 dogs with sarcoptic mange.
abstract: BACKGROUND
  There are few licensed options for the treatment of canine sarcoptic mange.
  
  
  OBJECTIVE
  To evaluate the efficacy of fluralaner in dogs with sarcoptic mange infestation.
  
  
  METHODS
  Seventeen dogs with a diagnosis of Sarcoptes scabiei based on positive skin scrapings.
  
  
  METHODS
  A single dose of oral fluralaner was administered according to the manufacturer's instructions. Assessments of pruritus and lesions were performed every 7 days for 1 month.
  
  
  RESULTS
  By Day 14 post-treatment, skin scrapings from all dogs were negative for mites. At the beginning of the study there was a negative correlation between body weight of the subject and pruritus [Pearson correlation coefficient (PCC) = -0.396, P = 0.007] and a positive correlation between pruritus and lesion severity (PCC 0.755, P = 0.0001). Significant decreases in lesion size and pruritus were observed within the first 14-21 days, respectively, and improvement in these parameters continued until the end of the study at Day 28.
  
  
  CONCLUSIONS
  Fluralaner was effective in eliminating scabies mites within 14 days and significantly resolved the clinical signs associated with sarcoptic mange within 21 days after a single dose.
authors: Centro Universitario UAEM Amecameca, Universidad Autónoma del Estado de México, Carretera Amecameca-Ayapango Km 2.5, Amecameca de Juárez, CP 56900, Estado de México, México. cromeron@uaemex.mx.
authors: Camilo
authors: C
authors: Romero
authors: Doctorado en Ciencias Agropecuarias y Recursos Naturales, Universidad Autónoma del Estado de México, kilometro 14.5 carretera Toluca-Atlacomulco desviación a Tlachalo, El Cerrillo Piedras Blancas, Toluca, 50200, Estado de México, México.
authors: Rafael
authors: R
authors: Heredia
authors: Centro Universitario UAEM Amecameca, Universidad Autónoma del Estado de México, Carretera Amecameca-Ayapango Km 2.5, Amecameca de Juárez, CP 56900, Estado de México, México.
authors: Jocelyn
authors: J
authors: Pineda
authors: Licenciatura de Medicina Veterinaria y Zootecnia, Centro Universitario UAEM Amecameca, Universidad Autónoma del Estado de México, Carretera Amecameca-Ayapango Km 2.5, Amecameca de Juárez, 56900, Estado de México, México.
authors: Jonathan A
authors: JA
authors: Serrano
authors: Universidad Autónoma Metropolitana, Unidad Xochimilco, Calzada del Hueso 1100, Coyoacan, 04960, Mexico DF, México.
authors: Germán D
authors: GD
authors: Mendoza
authors: Clinica Veterinaria Alhaurin, Río Panuco No. 2424, Colonia México, Monterrey, 64740, NL, México.
authors: Porfirio
authors: P
authors: Trápala
authors: Veterinaria Dermatología Veterinaria Especializada, Argentina No. 690, colonia moderna, Guadalajara, 44190, Jalisco, México.
authors: Alberto M
authors: AM
authors: Cordero
mesh_terms: D000818:Animals; D004283:Dog Diseases / Q000188:drug therapy / Q000469:parasitology*; D004285:Dogs; D005260:Female; D007306:Insecticides / Q000627:therapeutic use*; D007555:Isoxazoles / Q000627:therapeutic use*; D008297:Male; D012532:Scabies / Q000188:drug therapy / Q000662:veterinary*
chemical_list: C000591860:A1443 compound; D007306:Insecticides; D007555:Isoxazoles