title: Liporotein-associated phospholipase-A2 can be a diagnostic marker inthe early stage diagnosis of acute mesenteric ischemia.
abstract: OBJECTIVE
  The purpose of this experimental study was to investigate the role of lipoprotein-associated phospholipase-A2 (Lp-PLA2) in the diagnosis of acute mesenteric ischemia (AMI) in the early stage.
  
  
  METHODS
  Twenty-seven New Zealand rabbits were randomly divided into 3 groups in this study. Blood specimens were obtained from the groups at hours 0, 1, 3, and 6. Using the blood samples drawn from all groups, Lp-PLA2 and C-reactive protein (CRP) parameters were investigated.
  
  
  RESULTS
  There was a significant rise in the levels of both Lp-PLA2 and CRP starting at hour 1 (P < 0.05) (hour 1; Lp-PLA2, P = 0.003) in the ischemia group. In the sham group, the levels of Lp-PLA2 and CRP started to rise at hour 3 (P < 0.05) (hour 3; Lp-PLA2, P = 0.011). At hour 6 of ischemia, the area under the ROC curve was 100%, and the cut-off value of 63.91 ng/mL revealed a sensitivity of 88% and a specificity of 100% for Lp-PLA2.
  
  
  CONCLUSIONS
  These findings showed the role of serum Lp-PLA2 and CRP levels in the early diagnosis of AMI. Thus, further studies are needed to describe the role of Lp-PLA2 in the early diagnosis of AMI.
authors: Department of Emergency, Training and Research Hospital of the Turkish Ministry of Health, Ordu University, Ordu, Turkey.
authors: Tarık
authors: T
authors: Acar
authors: Department of Emergency Medicine, Meram Faculty of Medicine, Necmettin Erbakan University, Konya, Turkey.
authors: Sedat
authors: S
authors: Koçak
authors: Department of Emergency Medicine, Meram Faculty of Medicine, Necmettin Erbakan University, Konya, Turkey.
authors: Başar
authors: B
authors: Cander
authors: Department of Emergency Medicine, Meram Faculty of Medicine, Necmettin Erbakan University, Konya, Turkey.
authors: Mehmet
authors: M
authors: Ergin
authors: Department of Emergency, Training and Research Hospital of the Turkish Ministry of Health, Ordu University, Ordu, Turkey.
authors: Cesareddin
authors: C
authors: Dikmetaş
mesh_terms: D043203:1-Alkyl-2-acetylglycerophosphocholine Esterase; D000818:Animals; D015415:Biomarkers; D002097:C-Reactive Protein; D065666:Mesenteric Ischemia; D012372:ROC Curve; D011817:Rabbits; D012307:Risk Factors
chemical_list: D015415:Biomarkers; D002097:C-Reactive Protein; D043203:1-Alkyl-2-acetylglycerophosphocholine Esterase
keywords: Acute mesenteric ischemia; C-reactive protein; experimental study; lipoprotein-associated phospholipase-A2