title: Targeting mitochondria: how intravacuolar bacterial pathogens manipulate mitochondria.
abstract: Manipulation of host cell function by bacterial pathogens is paramount for successful invasion and creation of a niche conducive to bacterial replication. Mitochondria play a role in many important cellular processes including energy production, cellular calcium homeostasis, lipid metabolism, haeme biosynthesis, immune signalling and apoptosis. The sophisticated integration of host cell processes by the mitochondrion have seen it emerge as a key target during bacterial infection of human host cells. This review highlights the targeting and interaction of this dynamic organelle by intravacuolar bacterial pathogens and the way that the modulation of mitochondrial function might contribute to pathogenesis.
authors: Department of Biochemistry and Molecular Biology and Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Parkville, VIC, 3010, Australia.
authors: Laura F
authors: LF
authors: Fielden
authors: Department of Biochemistry and Molecular Biology and Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Parkville, VIC, 3010, Australia.
authors: Yilin
authors: Y
authors: Kang
authors: Department of Microbiology and Immunology at the Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Parkville, VIC, 3000, Australia. hnewton@unimelb.edu.au.
authors: Hayley J
authors: HJ
authors: Newton
authors: Department of Biochemistry and Molecular Biology and Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Parkville, VIC, 3010, Australia. d.stojanovski@unimelb.edu.au.
authors: Diana
authors: http://orcid.org/0000-0002-0199-3222
authors: D
authors: Stojanovski
mesh_terms: D000818:Animals; D001419:Bacteria / Q000378:metabolism* / Q000472:pathogenicity; D001426:Bacterial Proteins / Q000378:metabolism; D006801:Humans; D007109:Immunity; D008928:Mitochondria / Q000378:metabolism*; D014617:Vacuoles / Q000378:metabolism* / Q000382:microbiology*; D037521:Virulence Factors / Q000378:metabolism
chemical_list: D001426:Bacterial Proteins; D037521:Virulence Factors
keywords: Bacterial effector proteins; Intravacuolar bacterial pathogens; Mitochondria; Mitochondrial function; Protein trafficking