title: HapLogic: A Predictive Human Leukocyte Antigen-Matching Algorithm to Enhance Rapid Identification of the Optimal Unrelated Hematopoietic Stem Cell Sources for Transplantation.
abstract: The search for a suitable human leukocyte antigen (HLA)-matched unrelated adult stem cell donor (URD) or umbilical cord blood unit (UCB) is a complex process. The National Marrow Donor Program (NMDP) developed a search algorithm known as HapLogic, which is currently provided within the NMDP Traxis application. The HapLogic algorithm has been in use since 2006 and has advanced URD/UCB HLA-matching technology. The algorithm has been shown to have high predictive accuracy, which can streamline URD/UCB selection and drive efficiencies in the search process to the benefit of the stem cell transplantation community. Here, we describe the fundamental components of the NMDP matching algorithm, output, validation, and future directions.
authors: National Marrow Donor Program, Minneapolis, Minnesota. Electronic address: jdehn@nmdp.org.
authors: Jason
authors: J
authors: Dehn
authors: National Marrow Donor Program, Minneapolis, Minnesota.
authors: Michelle
authors: M
authors: Setterholm
authors: National Marrow Donor Program, Minneapolis, Minnesota.
authors: Kelly
authors: K
authors: Buck
authors: National Marrow Donor Program, Minneapolis, Minnesota.
authors: Jane
authors: J
authors: Kempenich
authors: National Marrow Donor Program, Minneapolis, Minnesota.
authors: Beth
authors: B
authors: Beduhn
authors: National Marrow Donor Program, Minneapolis, Minnesota; Department of Pathology and Laboratory Medicine, Tulane Cancer Center, Tulane University School of Medicine, New Orleans, Louisiana.
authors: Loren
authors: L
authors: Gragert
authors: National Marrow Donor Program, Minneapolis, Minnesota.
authors: Abeer
authors: A
authors: Madbouly
authors: National Marrow Donor Program, Minneapolis, Minnesota.
authors: Stephanie
authors: S
authors: Fingerson
authors: National Marrow Donor Program, Minneapolis, Minnesota.
authors: Martin
authors: M
authors: Maiers
mesh_terms: D000465:Algorithms; D006680:HLA Antigens / Q000276:immunology; D018380:Hematopoietic Stem Cell Transplantation / Q000379:methods*; D006412:Hematopoietic Stem Cells / Q000276:immunology; D006650:Histocompatibility Testing / Q000379:methods*; D006801:Humans; D061349:Unrelated Donors
chemical_list: D006680:HLA Antigens
keywords: Cord blood unit selection; Donor selection; HLA matching; Predictive algorithm