title: MassARRAY determination of somatic oncogenic mutations in solid tumors: Moving forward to personalized medicine.
abstract: This article will review the impact of the recently developed MassARRAY technology on our understanding of cancer biology and treatment. Analysis of somatic mutations is a useful tool in selecting personalized therapy, and for predicting the outcome of many solid tumors. Here, we review the literature on the application of MassARRAY technology (Sequenom Hamburg, Germany) to determine the mutation profile of solid tumors from patients. We summarize the use of commercially available panels of mutations - such as OncoCarta™ or other combinations - and their concordance with results obtained by using other technologies, such as next generation sequencing.
authors: Department of Hematology and Medical Oncology, Biomedical Research Institute-INCLIVA, University of Valencia, Av. Blasco Ibañez 17, 46010 Valencia, Spain.
authors: Tania
authors: T
authors: Fleitas
authors: Department of Hematology and Medical Oncology, Biomedical Research Institute-INCLIVA, University of Valencia, Av. Blasco Ibañez 17, 46010 Valencia, Spain.
authors: Maider
authors: M
authors: Ibarrola-Villava
authors: Department of Hematology and Medical Oncology, Biomedical Research Institute-INCLIVA, University of Valencia, Av. Blasco Ibañez 17, 46010 Valencia, Spain. Electronic address: gribas@incliva.es.
authors: Gloria
authors: G
authors: Ribas
authors: Department of Hematology and Medical Oncology, Biomedical Research Institute-INCLIVA, University of Valencia, Av. Blasco Ibañez 17, 46010 Valencia, Spain. Electronic address: andres.cervantes@uv.es.
authors: Andrés
authors: A
authors: Cervantes
mesh_terms: D059014:High-Throughput Nucleotide Sequencing; D006801:Humans; D009154:Mutation; D009369:Neoplasms / Q000235:genetics*; D020411:Oligonucleotide Array Sequence Analysis; D009857:Oncogenes / Q000235:genetics*; D057285:Precision Medicine
keywords: MassARRAY technology; OncoCarta panel v1.0; Solid tumors; Somatic mutation profile