title: Graphene quantum dots decorated with magnetic nanoparticles: Synthesis, electrodeposition, characterization and application as an electrochemical sensor towards determination of some amino acids at physiological pH.
abstract: This study reports on the synthesis and characterization of a novel nano-composite, Fe3O4 magnetic nanoparticles/graphene quantum dots (Fe3O4 MNP-GQDs), for sensing of some amino acids. For the first time, as-synthesized GQDs and Fe3O4 MNPs-GQDs was electrodeposited on the glassy carbon electrode (GCE) by cyclic voltammetry (CV) regime in the potential range from -1.0 to 1.0V. Fe3O4 MNP-GQDs is engineered to specifically and effectively capture and enhancement the electrochemical signals of some amino acids at physiological pH due to the synergy among GQDs and magnetic nanoparticles. We have illustrated that the obtained Fe3O4 MNPs-GQDs exhibited a much higher electroactivity individual GQDs and Fe3O4 MNPs for the electrooxidation and detection of amino acid which was about 10 fold higher than for GQDs. Magnetic and specific properties of the Fe3O4 MNP-GQDs can be exploited to capture and pre-concentration the amino acids onto its surface, which are important for detection of multi-amino acids.
authors: Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz 51664, Iran; Pharmaceutical Analysis Research Center, Tabriz University of Medical Sciences, Tabriz 51664, Iran. Electronic address: mhmmd_hasanzadeh@yahoo.com.
authors: Mohammad
authors: M
authors: Hasanzadeh
authors: Department of Biochemistry, Higher Education Institute of Rab-Rashid, Tabriz, Iran; School of Medicine, Gonabad University of Medical Sciences, Gonabad, Iran.
authors: Ayub
authors: A
authors: Karimzadeh
authors: Department of Nanochemistry, Nano Technology Research Center, Urmia University, Urmia 57154, Iran; Department of Nano Technology, Faculty of Science, Urmia University, Urmia 57154, Iran.
authors: Nasrin
authors: N
authors: Shadjou
authors: School of Medicine, Gonabad University of Medical Sciences, Gonabad, Iran; Department of Biochemistry, Higher Education Institute of Rab-Rashid, Tabriz, Iran.
authors: Ahad
authors: A
authors: Mokhtarzadeh
authors: Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz 51664, Iran.
authors: Leyla
authors: L
authors: Bageri
authors: Department of Biochemistry, Higher Education Institute of Rab-Rashid, Tabriz, Iran.
authors: Sattar
authors: S
authors: Sadeghi
authors: Department of Biochemistry, Higher Education Institute of Rab-Rashid, Tabriz, Iran.
authors: Soltanali
authors: S
authors: Mahboob
mesh_terms: D000596:Amino Acids / Q000032:analysis*; D055664:Electrochemical Techniques / Q000379:methods*; D006863:Hydrogen-Ion Concentration; D058185:Magnetite Nanoparticles / Q000737:chemistry*; D053761:Nanocomposites / Q000737:chemistry*; D045663:Quantum Dots / Q000737:chemistry*
chemical_list: D000596:Amino Acids; D058185:Magnetite Nanoparticles
keywords: Amino acid; Electrochemical sensor; Graphene quantum dot; Magnetic nanoparticle