title: New Sesquiterpenenoids from Ainsliaea yunnanensis.
abstract: Investigation of the ethanol extract of the whole plant of Ainsliaea yunnanensis led to the isolation of four new dimeric sesquiterpene lactones, ainsliadimer F-I (1-4), together with seven known dimeric sesquiterpene lactones (5-11) and ten sesquiterpenes (12-21). Their structures were elucidated by spectroscopic methods. The relative stereochemistry of ainsliadimer F was further confirmed by single crystal X-ray diffraction analysis. Compounds 1-21 were tested for the inhibition of nuclear factor kappa B (NF-κB) in the 293-NF-κB-luciferase reporter cell line induced by lipopolysaccharide (LPS), and Compounds 5, 18, 20 and 21 were further tested for the production of TNF-α, IL-1β, IL-6 and IL-10 in RAW 264.7 macrophages induced by LPS. Compounds 5, 18, 20 and 21 exhibited significant activity in anti-inflammatory activity assays.
authors: Department of Pharmacy, Changzheng Hospital, Second Military Medical University, 415 Fengyang Road, Shanghai 200003, China. 15921754936@163.com.|College of Chemical and Biological Engineering, Yichun University, 576 Xuefu Road, Yichun 336000, China. 15921754936@163.com.
authors: Xiang-Lei
authors: XL
authors: Wu
authors: College of Chemical and Biological Engineering, Yichun University, 576 Xuefu Road, Yichun 336000, China. ycxxxj@163.com.
authors: Xiao-Juan
authors: XJ
authors: Xiong
authors: Department of Pharmacy, Changzheng Hospital, Second Military Medical University, 415 Fengyang Road, Shanghai 200003, China. lwqp@163.com.
authors: Wen-Quan
authors: WQ
authors: Lu
authors: College of Chemical and Biological Engineering, Yichun University, 576 Xuefu Road, Yichun 336000, China. jxychh2008@163.com.
authors: Hao
authors: H
authors: Huang
authors: College of Pharmacy, Second Military Medical University, 325 Guohe Road, Shanghai 200433, China. shenyunheng@hotmail.com.
authors: Yun-Heng
authors: YH
authors: Shen
authors: Department of Pharmacy, Changzheng Hospital, Second Military Medical University, 415 Fengyang Road, Shanghai 200003, China. wuzhijun999@sina.com.
authors: Zhi-Jun
authors: ZJ
authors: Wu
authors: Department of Pharmacy, Changzheng Hospital, Second Military Medical University, 415 Fengyang Road, Shanghai 200003, China. chenws126@126.com.
authors: Wan-Sheng
authors: WS
authors: Chen
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000737:chemistry* / Q000494:pharmacology; D019659:Asteraceae / Q000737:chemistry*; D018360:Crystallography, X-Ray; D016207:Cytokines / Q000378:metabolism*; D005786:Gene Expression Regulation / Q000187:drug effects; D007783:Lactones / Q000737:chemistry* / Q000494:pharmacology; D008070:Lipopolysaccharides / Q000009:adverse effects; D051379:Mice; D016328:NF-kappa B / Q000037:antagonists & inhibitors; D000067996:RAW 264.7 Cells; D012717:Sesquiterpenes / Q000737:chemistry* / Q000494:pharmacology
chemical_list: D000893:Anti-Inflammatory Agents; D016207:Cytokines; D007783:Lactones; D008070:Lipopolysaccharides; D016328:NF-kappa B; D012717:Sesquiterpenes
keywords: Ainsliaea; Ainsliaea yunnanensis; anti-inflammatory activity; sesquiterpenoid