title: [PROPHYLAXIS OF POSTOPERATIVE HYPERALGESIA, BASED ON MORPHOLOGICAL SUBSTANTIATION OF THE ANALGESIA METHOD].
abstract: The investigation was conducted in 20 children, operated on for abdominal oncological diseases in a 2010-2015 yrs period, using various methods of analgesia. While application of a constant infusion of high doses of phentanyl--1-4 MKr/(kg x h) in perioperative period the occurrence of the opiate-induced hyperalgesia is possible with the accompanied morphological changes in intestinal wall; in anesthesia of a transverse abdominal muscle (a TAP-blockade) and combined spinal epidural analgesia such changes were not observed.
authors: D V
authors: DV
authors: Dmytriyev
authors: V S
authors: VS
authors: Konoplytskyi
mesh_terms: D000009:Abdominal Muscles / Q000187:drug effects* / Q000294:innervation / Q000601:surgery; D000008:Abdominal Neoplasms / Q000473:pathology / Q000601:surgery; D000293:Adolescent; D015360:Analgesia, Epidural / Q000379:methods*; D000701:Analgesics, Opioid / Q000008:administration & dosage / Q000009:adverse effects*; D002648:Child; D002675:Child, Preschool; D005260:Female; D005283:Fentanyl / Q000008:administration & dosage / Q000009:adverse effects*; D006801:Humans; D006930:Hyperalgesia / Q000209:etiology / Q000473:pathology / Q000517:prevention & control*; D007223:Infant; D007263:Infusions, Parenteral; D008297:Male; D010149:Postoperative Pain / Q000503:physiopathology / Q000517:prevention & control; D011184:Postoperative Period; D012189:Retrospective Studies
chemical_list: D000701:Analgesics, Opioid; D005283:Fentanyl