title: Assessment of a rapid liquid-based cytology method for measuring sputum cell counts.
abstract: Differential sputum cell counting is not widely available despite proven clinical utility in the management of asthma. We compared eosinophil counts obtained using liquid-based cytology (LBC), a routine histopathological processing method, and the current standard method. Eosinophil counts obtained using LBC were a strong predictor of sputum eosinophilia (≥3%) determined by the standard method suggesting LBC could be used in the management of asthma.
authors: The Asthma Centre, Nottingham Respiratory Research Unit, University of Nottingham, Nottingham City Hospital, Nottingham, UK.
authors: M J
authors: MJ
authors: Martin
authors: The Asthma Centre, Nottingham Respiratory Research Unit, University of Nottingham, Nottingham City Hospital, Nottingham, UK.
authors: H
authors: H
authors: Lee
authors: The Asthma Centre, Nottingham Respiratory Research Unit, University of Nottingham, Nottingham City Hospital, Nottingham, UK.
authors: G
authors: G
authors: Meakin
authors: The Asthma Centre, Nottingham Respiratory Research Unit, University of Nottingham, Nottingham City Hospital, Nottingham, UK.
authors: A
authors: A
authors: Green
authors: The Asthma Centre, Nottingham Respiratory Research Unit, University of Nottingham, Nottingham City Hospital, Nottingham, UK.
authors: R L
authors: RL
authors: Simms
authors: The Asthma Centre, Nottingham Respiratory Research Unit, University of Nottingham, Nottingham City Hospital, Nottingham, UK.
authors: C
authors: C
authors: Reynolds
authors: Department of Cellular Pathology, Nottingham University Hospitals NHS Trust, Nottingham City Hospital, Nottingham, UK.
authors: S
authors: S
authors: Winters
authors: The Asthma Centre, Nottingham Respiratory Research Unit, University of Nottingham, Nottingham City Hospital, Nottingham, UK.
authors: D E
authors: DE
authors: Shaw
authors: Department of Cellular Pathology, Nottingham University Hospitals NHS Trust, Nottingham City Hospital, Nottingham, UK.
authors: I
authors: I
authors: Soomro
authors: The Asthma Centre, Nottingham Respiratory Research Unit, University of Nottingham, Nottingham City Hospital, Nottingham, UK.
authors: T W
authors: TW
authors: Harrison
mesh_terms: D000328:Adult; D000368:Aged; D001249:Asthma / Q000473:pathology*; D002452:Cell Count / Q000379:methods; D004804:Eosinophils / Q000473:pathology; D005260:Female; D006801:Humans; D007958:Leukocyte Count; D008297:Male; D008875:Middle Aged; D013048:Specimen Handling / Q000379:methods; D013183:Sputum / Q000166:cytology*
keywords: Asthma; Histology/Cytology