title: Single-center retrospective series of fourteen patients with mucosal melanoma of the nasal cavity and paranasal sinuses.
abstract: OBJECTIVE
  Mucosal melanoma of the nasal cavity and paranasal sinuses is a rare and highly aggressive tumor. We report our experience over 20 years in management of this tumor.
  
  
  METHODS
  A retrospective study included 14 patients with primary sinonasal mucosal melanoma.
  
  
  RESULTS
  The series comprised 8 male and 6 female patients, with a median age at diagnosis of 67 years. Staging on the American Joint Committee on Cancer classification of sinus cancer was 14% T2, 22% T3, 75% T4a and 7% T4b. All patients underwent primary surgical treatment; 71% received adjuvant external radiotherapy. Median recurrence-free interval was 28.7 months. Two- and 5-year overall survival was 43% and 32%, respectively. Median follow-up was 43 months.
  
  
  CONCLUSIONS
  Mucosal melanomas of the nasal cavity and paranasal sinuses are very specific entities. Limited pathophysiological knowledge still precludes effective medium- and long-term management. Future treatment will probably be based on global adjuvant or neoadjuvant-targeted chemotherapy.
authors: CHU Croix-Rousse, Service d'ORL et de Chirurgie de la Face et du Cou, 69006 Lyon, France. Electronic address: j.letievant@gmail.com.
authors: J-C
authors: JC
authors: Letievant
authors: CHU Croix-Rousse, Service d'ORL et de Chirurgie de la Face et du Cou, 69006 Lyon, France.
authors: M
authors: M
authors: Poupart
authors: CHU Croix-Rousse, Service d'ORL et de Chirurgie de la Face et du Cou, 69006 Lyon, France.
authors: A
authors: A
authors: Ambrun
authors: CHU Croix-Rousse, Service d'ORL et de Chirurgie de la Face et du Cou, 69006 Lyon, France.
authors: C
authors: C
authors: Colin
authors: CHU Croix-Rousse, Service d'ORL et de Chirurgie de la Face et du Cou, 69006 Lyon, France.
authors: J-C
authors: JC
authors: Pignat
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008545:Melanoma / Q000401:mortality / Q000473:pathology* / Q000628:therapy; D008875:Middle Aged; D009296:Nasal Cavity / Q000473:pathology* / Q000601:surgery; D009297:Nasal Mucosa / Q000473:pathology* / Q000601:surgery; D009364:Neoplasm Recurrence, Local; D009669:Nose Neoplasms / Q000401:mortality / Q000473:pathology* / Q000628:therapy; D010255:Paranasal Sinus Neoplasms / Q000401:mortality / Q000473:pathology* / Q000628:therapy; D018714:Radiotherapy, Adjuvant; D012189:Retrospective Studies
keywords: Mucosal melanoma; Nasal cavity; Paranasal sinuses