title: Abnormal Somatosensory Synchronization in Patients With Paroxysmal Kinesigenic Dyskinesia: A Magnetoencephalographic Study.
abstract: Paroxysmal kinesigenic dyskinesia (PKD) is a rare group of hyperkinetic movement disorders characterized by brief attacks of choreoathetosis or dystonia. To clarify the alterations of the functional connectivity within the somatosensory network in PKD patients, magnetoencephalographic (MEG) responses to paired median-nerve electrical stimulation were recorded in 10 PKD patients treated by carbamazepine or oxcarbamazepine and 22 age-matched controls. In patients, MEG recordings were obtained during drug-on and -off periods. Source-based functional connectivity analysis was performed between contralateral primary (cSI) and secondary (cSII), and ipsilateral secondary (iSII) somatosensory areas. During drug-off periods, patients with PKD demonstrated decreased cSI-iSII and increased cSII-iSII somatosensory connectivity at theta band. Drug-on periods lowered the functional connectivity in cSI-cSII at alpha and beta bands and in cSII-iSII at theta band compared with the drug-off periods. We suggest that altered theta functional connectivity in cSI-iSII and cSII-iSII could be the neurophysiological signatures in PKD.
authors: 1 Brain Research Center, National Yang-Ming University, Taipei, Taiwan.|2 Institute of Brain Science, National Yang-Ming University, Taipei, Taiwan.|3 Laboratory of Neurophysiology at Medical Research Division, Taipei Veterans General Hospital, Taipei, Taiwan.
authors: Fu-Jung
authors: FJ
authors: Hsiao
authors: 2 Institute of Brain Science, National Yang-Ming University, Taipei, Taiwan.|3 Laboratory of Neurophysiology at Medical Research Division, Taipei Veterans General Hospital, Taipei, Taiwan.|4 Department of Neurology, University of California, San Francisco, CA, USA.
authors: Wan-Yu
authors: WY
authors: Hsu
authors: 1 Brain Research Center, National Yang-Ming University, Taipei, Taiwan.|2 Institute of Brain Science, National Yang-Ming University, Taipei, Taiwan.|5 Department of Neurology, National Yang-Ming University, Taipei, Taiwan.|6 Department of Neurology, Taipei Veterans General Hospital, Taipei, Taiwan.
authors: Wei-Ta
authors: WT
authors: Chen
authors: 7 Department of Neurology, Chang Gung Memorial Hospital, Chang Gung University, Taoyuan, Taiwan.|8 College of Medicine, Chang Gung University, Taoyuan, Taiwan.
authors: Rou-Shayn
authors: RS
authors: Chen
authors: 1 Brain Research Center, National Yang-Ming University, Taipei, Taiwan.|2 Institute of Brain Science, National Yang-Ming University, Taipei, Taiwan.|3 Laboratory of Neurophysiology at Medical Research Division, Taipei Veterans General Hospital, Taipei, Taiwan.|5 Department of Neurology, National Yang-Ming University, Taipei, Taiwan.|6 Department of Neurology, Taipei Veterans General Hospital, Taipei, Taiwan.|9 Institute of Clinical Medicine, National Yang-Ming University, Taipei, Taiwan.|10 Institute of Physiology, National Yang-Ming University, Taipei, Taiwan.
authors: Yung-Yang
authors: YY
authors: Lin
mesh_terms: D000293:Adolescent; D000927:Anticonvulsants / Q000627:therapeutic use; D001931:Brain Mapping / Q000379:methods; D058256:Brain Waves / Q000187:drug effects*; D002648:Child; D003344:Cortical Synchronization / Q000187:drug effects*; D004421:Dystonia / Q000188:drug therapy* / Q000503:physiopathology*; D005260:Female; D006801:Humans; D015225:Magnetoencephalography / Q000187:drug effects / Q000379:methods*; D008297:Male; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013003:Somatosensory Cortex / Q000187:drug effects* / Q000503:physiopathology*; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D000927:Anticonvulsants
keywords: antiepileptic drugs (AEDs); functional connectivity; magnetoencephalagraphy (MEG); paroxysmal kinesigenic dyskinesia (PKD); somatosensory evoked fields