title: TICK-BORNE ENCEPHALITIS VIRUS INFECTION IN HUMANS.
abstract: BACKGROUND
  Tick-borne meningoencephalitis virus is a flavivirus that causes the most important vector-borne central nervous system infection in many countries of Europe and Asia. There are three subtypes of tick-borne encephalitis virus: European, Siberian and the Far-Eastern subtype.
  
  
  METHODS
  In endemic areas, the virus remains in transmissive cycles between Ixodes ticks and small rodents.
  
  
  METHODS
  In most cases (70-98%) infection goes asymptomatically. In about one-third of meningitis cases, meningoencephalitis or meningomyelitis is developed. Postencephalytic syndrome may be the complication of the infection, presenting with neurological symptoms.
  
  
  METHODS
  Etiologic diagnosis of tick-borne meningoencephalitis is only made on basis of laboratory analyses. Reverse transcription-polymerase chain reaction is used for determining the presence of virus in the blood and cerebrospinal fluid. Antibodies in blood and cerebrospinal fluid can be detected by serological tests.
  
  
  CONCLUSIONS
  The most efficient way to control this potentially severe disease with possible serious long-term consequences is vaccination. It should be recommended to persons who live or travel to endemic areas.
  
  
  CONCLUSIONS
  In Serbia, tick-borne encephalitis virus infection belongs to the list of reportable diseases; however, there are no reported cases because the diagnostics is not performed routinely. We believe that the significance of this zoonosis must be examined in our country and some of its parts because of preliminary positive serological findings found out in Vojvodina as well as because of reported cases in neighboring countries such as Hungary and Croatia and its worldwide distribution.
authors: Ivana
authors: I
authors: Hrnjaković Cvjetković
authors: Dejan
authors: D
authors: Cvjetković
authors: Aleksandra
authors: A
authors: Patić
authors: Jelena
authors: J
authors: Radovanov
authors: Gordana
authors: G
authors: Kovacević
authors: Vesna
authors: V
authors: Milosević
mesh_terms: D000818:Animals; D000914:Antibodies, Viral / Q000097:blood / Q000134:cerebrospinal fluid; D001208:Asia / Q000453:epidemiology; D058345:Asymptomatic Infections; D004669:Encephalitis Viruses, Tick-Borne / Q000235:genetics; D004675:Encephalitis, Tick-Borne / Q000175:diagnosis / Q000453:epidemiology* / Q000517:prevention & control; D019353:Endemic Diseases; D005060:Europe / Q000453:epidemiology; D006801:Humans; D007303:Insect Vectors / Q000821:virology; D018884:Ixodes / Q000821:virology; D020133:Reverse Transcriptase Polymerase Chain Reaction; D014765:Viral Vaccines / Q000627:therapeutic use
chemical_list: D000914:Antibodies, Viral; D014765:Viral Vaccines