title: Analysis of Polymorphism of Angiotensin System Genes (ACE, AGTR1, and AGT) and Gene ITGB3 in Patients with Arterial Hypertension in Combination with Metabolic Syndrome.
abstract: Changes in the frequencies of genotypes and mutant alleles of ACE, AGTR1, AGT, and ITGB3 genes were analyzed in patients with arterial hypertension coupled with metabolic syndrome (N=15) and compared with population data and corresponding parameters in patients with isolated hypertension (N=15). Increased frequency of genotype ID of ACE gene (hypertension predictor) was confirmed for both groups. In case of isolated hypertension, M235M genotype (gene AGT) was more frequent, in case of hypertension combined with metabolic syndrome, the frequency of genotypes A1166C and C1166C of the gene AGTR1 was higher in comparison with population data. Comparison of mutant allele frequencies in the two groups showed that at the 90% significance level allele T of the AGT gene was more frequent in hypertension coupled with metabolic syndrome (OR=1.26) and genotype A1166A of the AGTR1 gene was more frequent in the group with isolated hypertension.
authors: Medical Faculty, the People's Friendship University of Russia, Moscow, Russia. zotovat@mail.ru.
authors: T Yu
authors: TY
authors: Zotova
authors: Medical Faculty, the People's Friendship University of Russia, Moscow, Russia.
authors: A P
authors: AP
authors: Kubanova
authors: Medical Faculty, the People's Friendship University of Russia, Moscow, Russia.
authors: M M
authors: MM
authors: Azova
authors: Medical Faculty, the People's Friendship University of Russia, Moscow, Russia.
authors: A Ait
authors: AA
authors: Aissa
authors: Medical Faculty, the People's Friendship University of Russia, Moscow, Russia.
authors: O O
authors: OO
authors: Gigani
authors: Medical Faculty, the People's Friendship University of Russia, Moscow, Russia.
authors: V A
authors: VA
authors: Frolov
mesh_terms: D000368:Aged; D000808:Angiotensinogen / Q000235:genetics; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease / Q000235:genetics; D005838:Genotype; D006801:Humans; D006973:Hypertension / Q000235:genetics*; D039661:Integrin beta3 / Q000235:genetics; D008297:Male; D024821:Metabolic Syndrome / Q000235:genetics*; D008875:Middle Aged; D007703:Peptidyl-Dipeptidase A / Q000235:genetics; D011110:Polymorphism, Genetic / Q000235:genetics*; D044140:Receptor, Angiotensin, Type 1 / Q000235:genetics; D012084:Renin-Angiotensin System / Q000235:genetics
chemical_list: C534931:AGT protein, human; C544065:AGTR1 protein, human; C061248:ITGB3 protein, human; D039661:Integrin beta3; D044140:Receptor, Angiotensin, Type 1; D000808:Angiotensinogen; D007703:Peptidyl-Dipeptidase A
keywords: gene polymorphism; hypertension; metabolic syndrome; rennin–angiotensin–aldosterone system