title: Safety and efficacy of direct oral anticoagulants over warfarin in Japanese patients with acute venous thromboembolism: A meta-analysis.
abstract: Direct oral anticoagulants (DOACs) have been developed as alternatives to conventional therapy with warfarin for the treatment of acute venous thromboembolism (VTE) events. The safety and efficacy of DOACs in Japanese patients with acute VTE has been investigated in small trials or subgroups from global randomized controlled trials (RCTs).
  
  
  
  We conducted a systematic review and meta-analysis of RCTs, to compare the safety and efficacy of DOACs to those of conventional therapy in Japanese patients with acute VTE. Published research was systematically searched for RCTs that compared DOAC to conventional therapy in Japanese patients with acute VTE. Random-effects models were used to pool safety and efficacy data across RCTs. Three studies, including 386 patients, were identified. Patients randomized to DOAC had a decreased risk for all bleeding [risk ratio (RR) 0.69, 95% confidential interval (CI) 0.50-0.95], without any significant differences in recurrent VTE (RR 0.84, 95% CI 0.29-2.43) and recurrent VTE/all-cause death (RR 0.60, 95% CI 0.23-1.56).
  
  
  
  DOACs offer clinical benefit over conventional therapy in Japanese patients with acute VTE, showing a significant difference in their bleeding profile.
authors: Department of Arrhythmia, Koseika Takeda Hospital, Kyoto, Japan; Department of Advanced Cardiovascular Therapeutics, Chiba University Graduate School of Medicine, Chiba, Japan. Electronic address: swcqg251@yahoo.co.jp.
authors: Keitaro
authors: K
authors: Senoo
authors: Department of Advanced Cardiovascular Therapeutics, Chiba University Graduate School of Medicine, Chiba, Japan.
authors: Yusuke
authors: Y
authors: Kondo
authors: Department of Cardiovascular Medicine, Chiba University Graduate School of Medicine, Chiba, Japan.
authors: Kazuo
authors: K
authors: Miyazawa
authors: Department of Cardiology, Tokyo Metropolitan Tama Medical Center, Tokyo, Japan.
authors: Toshiaki
authors: T
authors: Isogai
authors: Department of Arrhythmia, Koseika Takeda Hospital, Kyoto, Japan.
authors: Yeong-Hwa
authors: YH
authors: Chun
authors: Department of Cardiovascular Medicine, Chiba University Graduate School of Medicine, Chiba, Japan.
authors: Yoshio
authors: Y
authors: Kobayashi
mesh_terms: D000284:Administration, Oral; D000925:Anticoagulants / Q000627:therapeutic use*; D044466:Asian People; D006470:Hemorrhage / Q000139:chemically induced; D006801:Humans; D007564:Japan; D016032:Randomized Controlled Trials as Topic; D055502:Secondary Prevention; D054556:Venous Thromboembolism / Q000188:drug therapy* / Q000517:prevention & control; D014859:Warfarin / Q000627:therapeutic use*
chemical_list: D000925:Anticoagulants; D014859:Warfarin
keywords: Direct oral anticoagulants; Japanese; Meta-analysis; Venous thromboembolism