title: Association between osteocalcin and cognitive performance in healthy older adults.
abstract: cognitive deterioration and reductions of bone health coincide with increasing age. We examine the relationship between bone composition and plasma markers of bone remodelling with measures of cognitive performance in healthy adults.
  
  
  
  this cross-sectional study included 225 old (52% women, mean age: 74.4 ± 3.3 years) and 134 young (52% women, mean age: 23.4 ± 2.7 years) adult participants from the MyoAge project. Whole body bone mineral density was measured by dual-energy X-ray absorptiometry. Blood analyses included a panel of bone-related peptides (dickkopf-1, osteoprotegerin, osteocalcin (OC), osteopontin, sclerostin, parathyroid hormone and fibroblast growth factor 23), as well as serum calcium and 25-hydroxy vitamin D assays. A selection of cognitive domains (working memory capacity, episodic memory, executive functioning and global cognition) was assessed with a standardised neuropsychological test battery.
  
  
  
  adjusting for covariates and multiple testing revealed that plasma OC levels were positively associated with measures of executive functioning (β = 0.444, P < 0.001) and global cognition (β = 0.381, P = 0.001) in the older women.
  
  
  
  these correlative results demonstrate a positive association between OC, a factor known to regulate bone remodelling, with cognitive performance in older non-demented women. Further work should address possible mechanistic interpretations in humans.
authors: Manchester Metropolitan University, School of Healthcare Science, Manchester, UK.
authors: Steven
authors: S
authors: Bradburn
authors: Manchester Metropolitan University, School of Healthcare Science, Manchester, UK.
authors: Jamie S
authors: JS
authors: McPhee
authors: Manchester Metropolitan University, School of Healthcare Science, Manchester, UK.
authors: Liam
authors: L
authors: Bagley
authors: University of Jyväskylä, Gerontology Research Centre, Health Sciences, 40630 Jyväskylä, Finland.
authors: Sarianna
authors: S
authors: Sipila
authors: University of Jyväskylä, Gerontology Research Centre, Health Sciences, 40630 Jyväskylä, Finland.
authors: Lauri
authors: L
authors: Stenroth
authors: University of Nottingham, Faculty of Medicine and Health Sciences, Derby, UK.
authors: Marco Vincenzo
authors: MV
authors: Narici
authors: University of Tartu, Institute of Exercise Biology and Physiotherapy, Tartu, Estonia.
authors: Mati
authors: M
authors: Pääsuke
authors: University of Tartu, Institute of Exercise Biology and Physiotherapy, Tartu, Estonia.
authors: Helena
authors: H
authors: Gapeyeva
authors: Unilever Discover, Colworth Park, Sharnbrook, Bedford, UK.
authors: Gabrielle
authors: G
authors: Osborne
authors: Unilever Discover, Colworth Park, Sharnbrook, Bedford, UK.
authors: Lorraine
authors: L
authors: Sassano
authors: VU University Medical Center, Rehabilitation Medicine, Amsterdam, The Netherlands.
authors: Carel G M
authors: CG
authors: Meskers
authors: VU University Medical Center, Faculty of Human Movement Sciences, Amsterdam, The Netherlands.|Royal Melbourne Hospital, University of Melbourne, Melbourne, Australia.
authors: Andrea B
authors: AB
authors: Maier
authors: Institut de Myologie, 75634 Paris Cedex 13, France.
authors: Jean-Yves
authors: JY
authors: Hogrel
authors: Institut de Myologie, 75634 Paris Cedex 13, France.
authors: Yoann
authors: Y
authors: Barnouin
authors: Institut de Myologie, 75634 Paris Cedex 13, France.
authors: Gillian
authors: G
authors: Butler-Browne
authors: Manchester Metropolitan University, School of Healthcare Science, Manchester, UK.
authors: Chris
authors: C
authors: Murgatroyd
mesh_terms: D015502:Absorptiometry, Photon; D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000097:blood* / Q000523:psychology*; D015415:Biomarkers / Q000097:blood; D015519:Bone Density; D001851:Bone Diseases, Metabolic / Q000097:blood* / Q000175:diagnosis / Q000453:epidemiology; D016723:Bone Remodeling; D003071:Cognition; D003072:Cognition Disorders / Q000175:diagnosis / Q000453:epidemiology / Q000523:psychology*; D000066492:Cognitive Aging / Q000523:psychology*; D003430:Cross-Sectional Studies; D005060:Europe; D056344:Executive Function; D005260:Female; D006801:Humans; D008297:Male; D061212:Memory, Episodic; D008570:Memory, Short-Term; D009483:Neuropsychological Tests; D015675:Osteocalcin / Q000097:blood*; D012737:Sex Factors; D055815:Young Adult
chemical_list: D015415:Biomarkers; D015675:Osteocalcin
keywords: ageing; cognitive decline; older people; osteocalcin