title: Investigation of 5-(3-Trifluoromethylbenzylidene)thiazolidine-2,4-dione as a Matrix for Analyses of Biogenic Monoamine Transmitters Using MALDI-MS.
abstract: In order to discover new matrices suitable for the analyses of low molecular-weight compounds using positive-ion mode matrix-assisted laser desorption/ionization (MALDI) time-of-flight mass spectrometry (MS), 5-(3-trifluoromethylbenzylidene)thiazolidine-2,4-dione (3-CF3-BTD) was synthesized, and its effectiveness was compared with that when commercially available α-cyano-4-hydroxycinnamic acid was used. 3-CF3-BTD was sufficiently sensitive to analyze neurotransmitters, i.e., dopamine, serotonin, histamine, and epinephrine, in amounts of several picomoles. Similar to vacuum MALDI experiments, atmospheric-pressure MALDI-MS measurements using 3-CF3-BTD as a matrix also detected dopamine.
authors: Central Research Laboratory, Hoshi University.
authors: Hiroko
authors: H
authors: Kasai
authors: Masamichi
authors: M
authors: Nakakoshi
authors: Tomomi
authors: T
authors: Sugita
authors: Mayu
authors: M
authors: Matsuoka
authors: Yuzo
authors: Y
authors: Yamazaki
authors: Yumi
authors: Y
authors: Unno
authors: Hiroki
authors: H
authors: Nakajima
authors: Hideshi
authors: H
authors: Fujiwake
authors: Masayoshi
authors: M
authors: Tsubuki
mesh_terms: D015306:Biogenic Monoamines / Q000032:analysis*; D018377:Neurotransmitter Agents / Q000032:analysis*; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / Q000379:methods*; D045162:Thiazolidinediones / Q000737:chemistry*
chemical_list: C000625991:5-(3-trifluoromethylbenzylidene)thiazolidine-2,4-dione; D015306:Biogenic Monoamines; D018377:Neurotransmitter Agents; D045162:Thiazolidinediones