title: Adenosine Type A2A Receptor in Peripheral Cell from Patients with Alzheimer's Disease, Vascular Dementia, and Idiopathic Normal Pressure Hydrocephalus: A New/Old Potential Target.
abstract: As the European population gets older, the incidence of neurological disorders increases with significant impact on social costs. Despite differences in disease etiology, several brain disorders in the elderly (e.g., Alzheimer's disease, vascular dementia, normal pressure hydrocephalus) share dementia as a common clinical feature. The current treatment for the majority of these diseases is merely symptomatic and does not modify the course of the illness. Symptoms of normal pressure hydrocephalus are the only ones that can be modified if they are recognized in time and treated appropriately. Therefore, an important clinical strategy may be disclosed by pathogenic pathways that can be modified and to find drugs that can slow down or even arrest disease progression. Possibly a way to answer this question could be by re-examining all the molecules which have so far succeeded in improving many aspects of cognitive deterioration in some neurodegenerative conditions, that were not considered because of controversial opinions. The main purpose of this summary is to further substantiate the hypothesis that the pathway of adenosine type A2A receptor could be used as a potential target to develop new/old therapeutic strategies.
authors: Geriatric Unit, Department of Medical Sciences and Community Health, University of Milan, Milan, Italy.|Fondazione Ca' Granda, IRCCS Ospedale Maggiore Policlinico, Milan, Italy.
authors: Beatrice
authors: B
authors: Arosio
authors: Geriatric Unit, Department of Medical Sciences and Community Health, University of Milan, Milan, Italy.|Nutritional Sciences, University of Milan, Milan, Italy.
authors: Martina
authors: M
authors: Casati
authors: Geriatric Unit, Department of Medical Sciences and Community Health, University of Milan, Milan, Italy.
authors: Cristina
authors: C
authors: Gussago
authors: Geriatric Unit, Department of Medical Sciences and Community Health, University of Milan, Milan, Italy.|Nutritional Sciences, University of Milan, Milan, Italy.
authors: Evelyn
authors: E
authors: Ferri
authors: Fondazione Ca' Granda, IRCCS Ospedale Maggiore Policlinico, Milan, Italy.
authors: Carlo
authors: C
authors: Abbate
authors: Fondazione Ca' Granda, IRCCS Ospedale Maggiore Policlinico, Milan, Italy.
authors: Valeria
authors: V
authors: Scortichini
authors: Geriatric Unit, Department of Medical Sciences and Community Health, University of Milan, Milan, Italy.
authors: Elena
authors: E
authors: Colombo
authors: Fondazione Ca' Granda, IRCCS Ospedale Maggiore Policlinico, Milan, Italy.
authors: Paolo Dionigi
authors: PD
authors: Rossi
authors: Geriatric Unit, Department of Medical Sciences and Community Health, University of Milan, Milan, Italy.|Fondazione Ca' Granda, IRCCS Ospedale Maggiore Policlinico, Milan, Italy.
authors: Daniela
authors: D
authors: Mari
mesh_terms: D000544:Alzheimer Disease / Q000188:drug therapy / Q000378:metabolism*; D015140:Dementia, Vascular / Q000188:drug therapy / Q000378:metabolism*; D016503:Drug Delivery Systems / Q000639:trends; D006801:Humans; D006850:Hydrocephalus, Normal Pressure / Q000188:drug therapy / Q000378:metabolism*; D007963:Leukocytes, Mononuclear / Q000187:drug effects / Q000378:metabolism*; D018696:Neuroprotective Agents / Q000008:administration & dosage; D043705:Receptor, Adenosine A2A / Q000378:metabolism*
chemical_list: D018696:Neuroprotective Agents; D043705:Receptor, Adenosine A2A
keywords: Adenosine; adenosine receptors; elderly; neurodegeneration