title: Aluminium chloride-induced toxicity in zebrafish larvae.
abstract: Embryos at shield stage and larvae at protruding mouth stage were exposed to different concentrations of aluminium chloride (AlCl3) for 72 h with the purpose to analyse their phenotype and lethality. After 24, 48 and 72 h of treatment, higher toxicity of the metal was observed on larvae with minimal lethal concentration of 0.25, 0.20 and 0.08 mm, respectively, while for embryos the corresponding values were 40, 25 and 16 mm. We observed pericardial oedema and alteration of heart rate in 50% of larvae after 48 h of exposure to 100 μm. In larvae exposed to the same concentration, there was also a neurological injury at the level of glial cells, with the number of glial fibrillary acidic protein-positive cells being significantly reduced. This study confirms the toxic nature of this metal and shows that aluminium could also interestingly represent a cardiotoxin in addition to its neurotoxic ability.
authors: Department of Biology, University of Naples Federico II, Napoli, Italy.
authors: A
authors: A
authors: Monaco
authors: Department of Biology, University of Naples Federico II, Napoli, Italy.
authors: M C
authors: MC
authors: Grimaldi
authors: Department of Biology, University of Naples Federico II, Napoli, Italy.
authors: I
authors: I
authors: Ferrandino
mesh_terms: D000077410:Aluminum Chloride; D017607:Aluminum Compounds / Q000633:toxicity*; D000818:Animals; D001253:Astrocytes / Q000187:drug effects* / Q000378:metabolism; D015415:Biomarkers / Q000378:metabolism; D002712:Chlorides / Q000633:toxicity*; D004625:Embryo, Nonmammalian / Q000187:drug effects / Q000378:metabolism; D005904:Glial Fibrillary Acidic Protein / Q000378:metabolism; D014874:Water Pollutants, Chemical / Q000633:toxicity*; D015027:Zebrafish / Q000254:growth & development / Q000378:metabolism*; D029961:Zebrafish Proteins / Q000378:metabolism
chemical_list: D017607:Aluminum Compounds; D015415:Biomarkers; D002712:Chlorides; D005904:Glial Fibrillary Acidic Protein; D014874:Water Pollutants, Chemical; D029961:Zebrafish Proteins; D000077410:Aluminum Chloride
keywords: aluminium; cardiotoxicity; glial fibrillary acidic protein; zebrafish