title: Correlation of Ki-67 proliferation index and 18-fluorodeoxyglucose uptake in colorectal incidental lesions detected by positron emission tomography-computed tomography.
abstract: OBJECTIVE
  To investigate whether focal high maximum standardized uptake value (SUVmax) determined by 18-fluorodeoxyglucose (FDG) positron emission tomography (PET)-computed tomography (CT) imaging is correlated with proliferation index in the colorectal region.
  
  
  METHODS
  SUVmax values of 31 colorectal neoplasms that were incidentally detected during PET-CT examination were compared to dysplasia degree, histopathologic diagnosis, and immunohistochemical expression of the Ki-67 proliferation marker.
  
  
  RESULTS
  Statistically significant correlations were found between SUVmax and Ki-67 proliferation index, dysplasia degree, and histopathologic diagnosis. Median SUVmax value was found to be significantly higher in high-risk lesions than low-risk lesions.
  
  
  CONCLUSIONS
  The Ki-67 proliferation index is an indicator of SUVmax in colorectal tract. SUVmax values can predict malignancy and prognosis in this region. Colonoscopy and biopsy should always be performed whenever a focal high FDG uptake is determined incidentally in a patient.
authors: Department of Pathology, Keçiören Training and Research Hospital, Ankara, Turkey.
authors: Servet
authors: S
authors: Güreşci
authors: Department of Nuclear Medicine, Atatürk Chest Diseases and Thoracic Surgery Training and Research Hospital, Ankara, Turkey.
authors: Özlem
authors: Ö
authors: Özmen
authors: Department of Gastroenterology, Keçiören Training and Research Hospital, Ankara, Turkey.
authors: Metin
authors: M
authors: Uzman
authors: Department of Pathology, Keçiören Training and Research Hospital, Ankara, Turkey.
authors: Gülçin
authors: G
authors: Şimşek
authors: Department of Nuclear Medicine, Atatürk Chest Diseases and Thoracic Surgery Training and Research Hospital, Ankara, Turkey.
authors: Ebru
authors: E
authors: Tatci
authors: Department of Radiology, Atatürk Chest Diseases and Thoracic Surgery Training and Research Hospital, Ankara, Turkey.
authors: Atila
authors: A
authors: Gökçek
authors: Department of Gastroenterology, Keçiören Training and Research Hospital, Ankara, Turkey.
authors: Abdullah Özgür
authors: AÖ
authors: Yeniova
mesh_terms: D049109:Cell Proliferation; D015179:Colorectal Neoplasms; D019788:Fluorodeoxyglucose F18; D006801:Humans; D064847:Multimodal Imaging; D000072078:Positron Emission Tomography Computed Tomography; D049268:Positron-Emission Tomography; D019275:Radiopharmaceuticals; D012189:Retrospective Studies; D014057:Tomography, X-Ray Computed
chemical_list: D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18
keywords: Colorectal neoplasm; Ki-67 antigen; positron emission tomography