title: Molecular phylogeny of a genetically divergent hantavirus harbored by the Geoffroy's rousette (Rousettus amplexicaudatus), a frugivorous bat species in the Philippines.
abstract: The recent discovery of genetically distinct hantaviruses in multiple species of shrews and moles (order Eulipotyphla, families Soricidae and Talpidae) prompted a further exploration of their host diversification and geographic distribution by analyzing lung tissues from 376 fruit bats representing six genera (order Chiroptera, suborder Yinpterochiroptera, family Pteropodidae), collected in the Republic of the Philippines during 2008 to 2013. Hantavirus RNA was detected by RT-PCR in one of 15 Geoffroy's rousettes (Rousettus amplexicaudatus), captured in Quezon Memorial National Park on Luzon Island in 2009. Phylogenetic analyses of the S, M and L segments, using maximum-likelihood and Bayesian methods, showed that the newfound hantavirus, designated Quezon virus (QZNV), shared a common ancestry with hantaviruses hosted by insectivorous bats, in keeping with their evolutionary relationships and suggests that ancestral bats may have served as the early or original mammalian hosts of primordial hantaviruses. As the first hantavirus detected in a megabat or flying fox species, QZNV extends our knowledge about the reservoir host range.
authors: Infectious Disease Surveillance Center, National Institute of Infectious Diseases, Tokyo, Japan. Electronic address: arais@nih.go.jp.
authors: Satoru
authors: S
authors: Arai
authors: Department of Virology I, National Institute of Infectious Diseases, Tokyo, Japan.
authors: Satoshi
authors: S
authors: Taniguchi
authors: Infectious Disease Surveillance Center, National Institute of Infectious Diseases, Tokyo, Japan.
authors: Keita
authors: K
authors: Aoki
authors: Department of Animal Risk Management, Chiba Institute of Science, Chiba, Japan.
authors: Yasuhiro
authors: Y
authors: Yoshikawa
authors: Department of Biomedical Science, University of Tokyo, Tokyo, Japan.
authors: Shigeru
authors: S
authors: Kyuwa
authors: Infectious Disease Surveillance Center, National Institute of Infectious Diseases, Tokyo, Japan.
authors: Keiko
authors: K
authors: Tanaka-Taya
authors: College of Veterinary Medicine, University of the Philippines Los Baños, Laguna, Philippines.
authors: Joseph S
authors: JS
authors: Masangkay
authors: Research and Education Center for Prevention of Global Infectious Diseases of Animals, Tokyo University of Agriculture and Technology, Tokyo, Japan.
authors: Tsutomu
authors: T
authors: Omatsu
authors: College of Science, University of the Philippines Mindanao, Bago-Oshiro, Davao, Philippines.
authors: Roberto
authors: R
authors: Puentespina
authors: Department of Virology I, National Institute of Infectious Diseases, Tokyo, Japan.
authors: Shumpei
authors: S
authors: Watanabe
authors: Museum of Natural History, University of the Philippines Los Baños, Laguna, Philippines.
authors: Phillip
authors: P
authors: Alviola
authors: Museum of Natural History, University of the Philippines Los Baños, Laguna, Philippines.
authors: James
authors: J
authors: Alvarez
authors: Museum of Natural History, University of the Philippines Los Baños, Laguna, Philippines.
authors: Eduardo
authors: E
authors: Eres
authors: Museum of Natural History, University of the Philippines Los Baños, Laguna, Philippines.
authors: Edison
authors: E
authors: Cosico
authors: Museum of Natural History, University of the Philippines Los Baños, Laguna, Philippines.
authors: Ma Niña Regina M
authors: MNRM
authors: Quibod
authors: Department of Veterinary Science, National Institute of Infectious Diseases, Tokyo, Japan.
authors: Shigeru
authors: S
authors: Morikawa
authors: Departments of Pediatrics and Tropical Medicine, Medical Microbiology and Pharmacology, John A. Burns School of Medicine, University of Hawaii at Manoa, Honolulu, HI, USA.
authors: Richard
authors: R
authors: Yanagihara
authors: Infectious Disease Surveillance Center, National Institute of Infectious Diseases, Tokyo, Japan.
authors: Kazunori
authors: K
authors: Oishi
mesh_terms: D000818:Animals; D002685:Chiroptera / Q000821:virology*; D006476:Orthohantavirus / Q000145:classification* / Q000235:genetics*; D018778:Hantavirus Infections / Q000662:veterinary / Q000821:virology; D008168:Lung / Q000821:virology; D010679:Philippines; D010802:Phylogeny
keywords: Fruits bats; Hantavirus; Philippines; Phylogeny