title: Simultaneous determination of 6-mercaptopruine, 6-thioguanine and dasatinib as three important anticancer drugs using nanostructure voltammetric sensor employing Pt/MWCNTs and 1-butyl-3-methylimidazolium hexafluoro phosphate.
abstract: 6-Mercaptopurine, 6-thioguanine and dasatinib are three important anticancer drugs with high adverse effects in human body. In this study, a Pt/MWCNTs-1-butyl-3-methylimidazolium hexafluoro phosphate-modified carbon paste electrode was developed for the simultaneously determination of 6-mercaptopurine, 6-thioguanine and dasatinib for the first time. The Pt/MWCNTs synthesized by polyol method and have been characterized by transmission electron microscopy and X-ray diffraction methods. The obtained data revealed that the electro-oxidation of 6-mercaptopurine, 6-thioguanine and dasatinib is facilitated as a novel voltammetric sensor. After optimization of electrochemical parameters employing this sensor at pH 8.0, the oxidation peak currents for 6-mercaptopurine, 6-thioguanine and dasatinib were found to vary linearly with their concentrations in the range of 0.05-550μM; 0.1-500μM and 5.0-500μM with detection limits of 0.009μM, 0.05μM and 1.0μM respectively using square wave voltammetric method. The modified electrode has been applied for the selective and precise analysis of 6-mercaptopurine, 6-thioguanine and dasatinib in pharmaceutical formulations and urine samples.
authors: Department of Chemistry, Graduate University of Advanced Technology, Kerman, Iran. Electronic address: h.karimi.maleh@gmail.com.
authors: Hassan
authors: H
authors: Karimi-Maleh
authors: Department of Chemistry, Faculty of Sciences, University of Guilan, P.O. Box 1914, Rasht, Iran. Electronic address: shoja47@gmail.com.
authors: Abdollah Fallah
authors: AF
authors: Shojaei
authors: Department of Chemistry, Faculty of Sciences, University of Guilan, P.O. Box 1914, Rasht, Iran.
authors: Khalil
authors: K
authors: Tabatabaeian
authors: Pardis Compus, University of Guilan, P.O. Box 1841, Rasht, Iran.
authors: Fatemeh
authors: F
authors: Karimi
authors: Department of Biotechnology, Inst. of Science and High Technology and Environmental Sciences, Graduate University of Advanced Technology, Kerman, Iran.
authors: Shahryar
authors: S
authors: Shakeri
authors: Department of Physics, Qaemshahr Branch, Islamic Azad University, Qaemshahr, Iran.
authors: Reza
authors: R
authors: Moradi
mesh_terms: D000970:Antineoplastic Agents / Q000032:analysis / Q000737:chemistry / Q000652:urine; D045424:Complex Mixtures / Q000032:analysis / Q000737:chemistry; D003217:Conductometry / Q000295:instrumentation*; D000069439:Dasatinib / Q000032:analysis* / Q000737:chemistry / Q000652:urine; D004867:Equipment Design; D019544:Equipment Failure Analysis; D006801:Humans; D007093:Imidazoles / Q000737:chemistry*; D015122:Mercaptopurine / Q000032:analysis* / Q000737:chemistry / Q000652:urine; D053768:Metal Nanoparticles / Q000737:chemistry / Q000648:ultrastructure; D037742:Nanotubes, Carbon / Q000737:chemistry* / Q000648:ultrastructure; D010984:Platinum / Q000737:chemistry; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013866:Thioguanine / Q000032:analysis* / Q000737:chemistry / Q000652:urine
chemical_list: C525963:1-butyl-3-methylimidazolium; D000970:Antineoplastic Agents; D045424:Complex Mixtures; D007093:Imidazoles; D037742:Nanotubes, Carbon; D010984:Platinum; D015122:Mercaptopurine; D013866:Thioguanine; D000069439:Dasatinib
keywords: 6-Mercaptopurine; 6-Thioguanine; Dasatinib; Ionic liquid; Pt/MWCNTs; Sensor