title: Scorpion Venom Heat-Resistant Peptide Protects Transgenic Caenorhabditis elegans from β-Amyloid Toxicity.
abstract: Scorpion venom heat-resistant peptide (SVHRP) is a component purified from Buthus martensii Karsch scorpion venom. Our previous studies found SVHRP could enhance neurogenesis and inhibit microglia-mediated neuroinflammation in vivo. Here, we use the transgenic CL4176, CL2006, and CL2355 strains of Caenorhabditis elegans which express the human Aβ1-42 to investigate the effects and the possible mechanisms of SVHRP mediated protection against Aβ toxicity in vivo. The results showed that SVHRP-fed worms displayed remarkably decreased paralysis, less abundant toxic Aβ oligomers, reduced Aβ plaque deposition with respect to untreated animals. SVHRP also suppressed neuronal Aβ expression-induced defects in chemotaxis behavior and attenuated levels of ROS in the transgenic C. elegans. Taken together, these results suggest SVHRP could protect against Aβ-induced toxicity in C. elegans. Further studies need to be conducted in murine models and humans to analyze the effectiveness of the peptide.
authors: Department of Physiology, Dalian Medical University Dalian, China.
authors: Xiao-Gang
authors: XG
authors: Zhang
authors: Department of Physiology, Dalian Medical University Dalian, China.
authors: Xi
authors: X
authors: Wang
authors: Department of Neurology, the First Affiliated Hospital of Dalian Medical University Dalian, China.
authors: Ting-Ting
authors: TT
authors: Zhou
authors: Department of Physiology, Dalian Medical University Dalian, China.
authors: Xue-Fei
authors: XF
authors: Wu
authors: Department of Physiology, Dalian Medical University Dalian, China.
authors: Yan
authors: Y
authors: Peng
authors: Department of Physiology, Dalian Medical University Dalian, China.
authors: Wan-Qin
authors: WQ
authors: Zhang
authors: Department of Physiology, Dalian Medical University Dalian, China.
authors: Shao
authors: S
authors: Li
authors: Department of Physiology, Dalian Medical UniversityDalian, China; Liaoning Engineering Technology Centre of Target-based Nature Products for Prevention and Treatment of Ageing-related NeurodegenerationDalian, China.
authors: Jie
authors: J
authors: Zhao
keywords: C. elegans; alzheimer’s disease; amyloid beta-peptide; behavior; scorpion venom heat-resistant peptide