title: Parkinson Disease and Dementia.
abstract: Dementia is a frequent complication of Parkinson disease (PD) with a yearly incidence of around 10% of patients with PD. Lewy body pathology is the most important factor in the development of Parkinson disease dementia (PDD) and there is evidence for a synergistic effect with β-amyloid. The clinical phenotype in PDD extends beyond the dysexecutive syndrome that is often present in early PD and encompasses deficits in recognition memory, attention, and visual perception. Sleep disturbances, hallucinations, neuroleptic sensitivity, and fluctuations are often present. This review provides an update on current knowledge of PDD including aspects of epidemiology, pathology, clinical presentation, management, and prognosis.
authors: Division of Clinical Geriatrics, Department of Neurobiology, Care Sciences and Society, Center for Alzheimer Research, Karolinska Institutet, Stockholm, Sweden Department of Geriatric Medicine, Memory Clinic, Karolinska University Hospital, Stockholm, Sweden sara.garcia-ptacek@ki.se.
authors: Sara
authors: S
authors: Garcia-Ptacek
authors: Division of Clinical Geriatrics, Department of Neurobiology, Care Sciences and Society, Center for Alzheimer Research, Karolinska Institutet, Stockholm, Sweden Department of Neurology, University Medical Centre Ljubljana, Ljubljana, Slovenia.
authors: Milica G
authors: MG
authors: Kramberger
mesh_terms: D001921:Brain / Q000473:pathology*; D003704:Dementia / Q000175:diagnosis / Q000453:epidemiology* / Q000209:etiology; D006212:Hallucinations / Q000209:etiology*; D006801:Humans; D015994:Incidence; D020961:Lewy Body Disease / Q000150:complications* / Q000175:diagnosis / Q000523:psychology; D008297:Male; D010300:Parkinson Disease / Q000150:complications / Q000175:diagnosis* / Q000453:epidemiology; D012893:Sleep Wake Disorders / Q000209:etiology / Q000503:physiopathology
keywords: Parkinson disease dementia; dementia