title: The Use of Binary Polymeric Networks in Stabilizing Polyethylene Oxide Solid Dispersions.
abstract: The objective of this study was to determine if a high Tg polymer (Eudragit(®) S100) could be used to stabilize amorphous domains of polyethylene oxide (PEO) and hence improve the stability of binary polymer systems containing celecoxib (CX). We propose a novel method of stabilizing the amorphous PEO solid dispersion through inclusion of a miscible, high Tg polymer, namely, that can form strong inter-polymer interactions. The effects of inter-polymer interactions and miscibility between PEO and Eudragit S100 are considered. Polymer blends were first manufactured via hot-melt extrusion at different PEO/S100 ratios (70/30, 50/50, and 30/70 wt/wt). Differential scanning calorimetry and dynamic mechanical thermal analysis data suggested a good miscibility between PEO and S100 polymer blends, particularly at the 50/50 ratio. To further evaluate the system, CX/PEO/S100 ternary mixtures were extruded. Immediately after hot-melt extrusion, a single Tg that increased with increasing S100 content (anti-plasticization) was observed in all ternary systems. The absence of powder X-ray diffractometry crystalline Bragg's peaks also suggested amorphization of CX. Upon storage (40°C/75% relative humidity), the formulation containing PEO/S100 at a ratio of 50:50 was shown to be most stable. Fourier transform infrared studies confirmed the presence of hydrogen bonding between Eudragit S100 and PEO suggesting this was the principle reason for stabilization of the amorphous CX/PEO solid dispersion system.
authors: Pharmaceutical Engineering Group, School of Pharmacy, Medical Biology Centre, Queen's University, 97 Lisburn Road, Belfast BT9 7BL, Northern Ireland, UK.
authors: David S
authors: DS
authors: Jones
authors: Pharmaceutical Engineering Group, School of Pharmacy, Medical Biology Centre, Queen's University, 97 Lisburn Road, Belfast BT9 7BL, Northern Ireland, UK.
authors: Yiwei
authors: Y
authors: Tian
authors: Pharmaceutical Engineering Group, School of Pharmacy, Medical Biology Centre, Queen's University, 97 Lisburn Road, Belfast BT9 7BL, Northern Ireland, UK.
authors: Shu
authors: S
authors: Li
authors: Pharmaceutical Engineering Group, School of Pharmacy, Medical Biology Centre, Queen's University, 97 Lisburn Road, Belfast BT9 7BL, Northern Ireland, UK.
authors: Tao
authors: T
authors: Yu
authors: Pharmaceutical Engineering Group, School of Pharmacy, Medical Biology Centre, Queen's University, 97 Lisburn Road, Belfast BT9 7BL, Northern Ireland, UK.
authors: Osama A
authors: OA
authors: Abu-Diak
authors: Pharmaceutical Engineering Group, School of Pharmacy, Medical Biology Centre, Queen's University, 97 Lisburn Road, Belfast BT9 7BL, Northern Ireland, UK. Electronic address: g.andrews@qub.ac.uk.
authors: Gavin P
authors: GP
authors: Andrews
mesh_terms: D002152:Calorimetry, Differential Scanning / Q000379:methods; D004337:Drug Carriers / Q000032:analysis / Q000737:chemistry*; D004355:Drug Stability; D011092:Polyethylene Glycols / Q000032:analysis / Q000737:chemistry*; D011108:Polymers / Q000032:analysis / Q000737:chemistry*; D014961:X-Ray Diffraction / Q000379:methods
chemical_list: D004337:Drug Carriers; D011108:Polymers; D011092:Polyethylene Glycols
keywords: Flory-Huggins theory; hot-melt extrusion; inter-polymer interactions; polymer blends; solid dispersion