title: Multifunctional materials such as MCM-41÷Fe3O4÷folic acid as drug delivery system.
abstract: In this study, MCM-41 mesoporous silica nanoparticles (NPs) and MCM-41÷Fe3O4 mesoporous silica NPs were prepared by sol-gel method using CTAB (cetyltrimethylammonium bromide) as template and TEOS (tetraethyl orthosilicate) as silica precursor in order to use these materials as drug delivery system (DDS) for different biologically active agents. The MCM-41 and MCM-41÷Fe3O4 mesoporous silica NPs were characterized using specific physico-chemical methods [transmission electron microscopy (TEM), scanning electron microscopy (SEM), nitrogen adsorption and desorption studies - BET (Brunauer-Emmett-Teller) method, X-ray diffraction (XRD) and Fourier transform infrared (FTIR) spectroscopy], while the release studies were done by a high-performance liquid chromatography (HPLC)-modified method. The pH dependence of the delivery of folic acid from the mesoporous structures was analyzed and found that the release is pH sensitive. The lower delivery at strongly acid pH comparing with neutral/slightly alkaline pH could be beneficial because in stomach the folic acid can be destroyed.
authors: Faculty of Applied Chemistry and Material Science, Politehnica University of Bucharest, Romania; denisaficai@yahoo.ro.
authors: Simona
authors: S
authors: Popescu
authors: Ioana Lavinia
authors: IL
authors: Ardelean
authors: Dragoş
authors: D
authors: Gudovan
authors: Marius
authors: M
authors: Rădulescu
authors: Denisa
authors: D
authors: Ficai
authors: Anton
authors: A
authors: Ficai
authors: Bogdan Ştefan
authors: BŞ
authors: Vasile
authors: Ecaterina
authors: E
authors: Andronescu
mesh_terms: D002453:Cell Cycle / Q000187:drug effects; D002460:Cell Line; D002853:Chromatography, Liquid; D016503:Drug Delivery Systems; D065546:Drug Liberation; D005290:Ferric Compounds / Q000737:chemistry* / Q000633:toxicity; D005492:Folic Acid / Q000737:chemistry* / Q000633:toxicity; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008855:Microscopy, Electron, Scanning; D009584:Nitrogen; D016062:Porosity; D012822:Silicon Dioxide / Q000737:chemistry* / Q000633:toxicity; D013052:Spectrometry, X-Ray Emission; D017550:Spectroscopy, Fourier Transform Infrared; D013696:Temperature; D018675:Toxicity Tests; D014961:X-Ray Diffraction
chemical_list: D005290:Ferric Compounds; C509968:MCM-41; C000499:ferric oxide; D012822:Silicon Dioxide; D005492:Folic Acid; D009584:Nitrogen