title: NF-κΒ and SOD expression in preeclamptic placentas.
abstract: OBJECTIVE
  Preeclampsia is a leading cause of maternal death in the developing world. Our aim was to quantify and compare messenger (mRNA) expression of nuclear factor-kappa beta (NF-κΒ) and superoxide dismutase (SOD) in control patients with preeclampsia and without preeclampsia with or without familial hereditary background.
  
  
  METHODS
  Four groups of patients were formed depending on the presence or absence of preeclampsia and presence or absence of familial history for preeclampsia. NF-κΒ and SOD were measured in human placentas by real-time quantitative polymerase chain reaction. The 2-ΔΔct analysis method was used to measure the difference in the relative expression of the target genes in each group of patients.
  
  
  RESULTS
  In NF-κΒ expression, there was an increase of 23.35% in the group of women with preeclampsia versus women with preeclampsia without familial history. Regarding SOD, there was a reduction of about 33.33% in the expression in women with preeclampsia with familial history versus women with preeclampsia without familial history.
  
  
  CONCLUSIONS
  Familial presence of preeclampsia could predispose to altered expression in SOD and NF-κΒ.
authors: Hospital General de México, SSA, Mexico City, Mexico.
authors: Abraham
authors: A
authors: Silva Carmona
authors: Maternal-Perinatal Hospital "Mónica Pretelini Sáenz" (HMPMPS), Health Institute of the State of Mexico (ISEM), Toluca, Mexico.
authors: Hugo
authors: H
authors: Mendieta Zerón
mesh_terms: D005260:Female; D006801:Humans; D016328:NF-kappa B; D010920:Placenta; D011225:Pre-Eclampsia; D011247:Pregnancy; D012333:RNA, Messenger; D013482:Superoxide Dismutase
chemical_list: D016328:NF-kappa B; D012333:RNA, Messenger; D013482:Superoxide Dismutase
keywords: Genetic background; nuclear factor-kappa beta; preeclampsia; superoxide dismutase