title: Expression of CD71 by flow cytometry in acute leukemias: More often seen in acute myeloid leukemia.
abstract: BACKGROUND
  CD71 is a marker that has been usually used for identifying dysplasia in the erythroid series. We have tried to evaluate the expression of CD71 in various types of acute leukemias.
  
  
  METHODS
  We studied 48 patients of acute leukemia, of which 25 were acute myeloid leukemia (AML), 13 were precursor B-acute lymphoblastic leukemia (B-ALL), 8 were T-ALL, and 2 were mixed phenotype acute leukemia (T/myeloid) as per the WHO classification.
  
  
  RESULTS
  We found that the expression of CD71 was most prevalent in AMLs (84%), followed by T-ALL (50%) and least in B-ALL (30%).
  
  
  CONCLUSIONS
  This finding clearly shows the higher expression of CD71 in AMLs compared to other common type of leukemias, such as B- and T-ALL. We suggest that the high expression of CD71 in AMLs could be used as a diagnostic marker and may also be used for minimal residual disease analysis after further studies in posttreatment scenario. This study is the first of its kind in the South Asian population.
authors: Department of Pathology and Laboratory Medicine, Medanta - The Medicity, Gurgaon, Haryana, India.
authors: Amit
authors: A
authors: Pande
authors: Department of Pathology and Laboratory Medicine, Medanta - The Medicity, Gurgaon, Haryana, India.
authors: Pranav
authors: P
authors: Dorwal
authors: Department of Pathology and Laboratory Medicine, Medanta - The Medicity, Gurgaon, Haryana, India.
authors: Dharmendra
authors: D
authors: Jain
authors: Department of Pathology and Laboratory Medicine, Medanta - The Medicity, Gurgaon, Haryana, India.
authors: Neetu
authors: N
authors: Tyagi
authors: Department of Pathology and Laboratory Medicine, Medanta - The Medicity, Gurgaon, Haryana, India.
authors: Simmi
authors: S
authors: Mehra
authors: Department of Pathology and Laboratory Medicine, Medanta - The Medicity, Gurgaon, Haryana, India.
authors: Ritesh
authors: R
authors: Sachdev
authors: Department of Pathology and Laboratory Medicine, Medanta - The Medicity, Gurgaon, Haryana, India.
authors: Vimarsh
authors: V
authors: Raina
mesh_terms: D015703:Antigens, CD / Q000032:analysis*; D014408:Biomarkers, Tumor / Q000032:analysis; D005434:Flow Cytometry; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000473:pathology*; D015452:Precursor B-Cell Lymphoblastic Leukemia-Lymphoma / Q000473:pathology*; D054218:Precursor T-Cell Lymphoblastic Leukemia-Lymphoma / Q000473:pathology*; D011990:Receptors, Transferrin / Q000032:analysis*
chemical_list: D015703:Antigens, CD; D014408:Biomarkers, Tumor; C068126:CD71 antigen; D011990:Receptors, Transferrin