title: Pediatric salivary gland carcinomas: Diagnostic and therapeutic management.
abstract: To analyze clinical presentations, treatment modalities, and evolution of pediatric cases of salivary gland carcinomas to standardize care for these rare diseases.
  
  
  
  Multicentric, retrospective study.
  
  
  
  We included in this retrospective study all children and adolescents (aged ≤18 years) treated from 1992 to 2012 in six pediatric centers in Paris, France. Pathological tumor specimens of these cases were reviewed.
  
  
  
  Forty-three children were included (sex ratio male/female = 19/24, median age = 13 years). The parotid gland was the most common (37 cases) location for tumors. Histological subtypes were mucoepidermoid carcinomas (n = 20), acinic cell carcinomas (n = 14), and other (n = 9). Initial fine-needle aspiration was performed in 15 cases (33%), and was concordant to final diagnosis in three cases (20%). Primary surgery was performed in 42 patients, leading to a complete microscopic resection in 80%. Associated lymph node dissection was performed in 28 patients (homolateral: 27, bilateral: 1) and showed lymph node metastases in only two patients. One patient had distant metastases. Adjuvant irradiation was delivered to 11 patients (median: 60 Gy; range: 50-65) and chemotherapy in five cases. After a median follow-up of 5 years, six tumors relapsed, but no deaths occurred.
  
  
  
  Childhood salivary gland carcinomas have a good prognosis despite possible recurrences. Treatment is mainly based on surgery, with simultaneous node dissection in cases of clinical or radiologic node enlargement. Radiation therapy seems to be restricted to inoperable high-grade tumors or after recurrence.
  
  
  
  4 Laryngoscope, 127:140-147, 2017.
authors: Pediatric Ear, Nose, and Throat Department, Necker Hospital for Sick Children, Public Assistance-Hospitals of Paris, Paris, France.
authors: Céleste
authors: C
authors: Rebours
authors: Pediatric Ear, Nose, and Throat Department, Necker Hospital for Sick Children, Public Assistance-Hospitals of Paris, Paris, France.
authors: Vincent
authors: V
authors: Couloigner
authors: Department of Pathology, Necker Hospital for Sick Children, Public Assistance-Hospitals of Paris, Paris, France.
authors: Louise
authors: L
authors: Galmiche
authors: Department of Pathology, Gustave Roussy Institute, Grand Campus, Villejuif, France.
authors: Odile
authors: O
authors: Casiraghi
authors: Department of Pathology, Georges Pompidou European Hospital, Public Assistance-Hospitals of Paris, Paris, France.
authors: Cécile
authors: C
authors: Badoual
authors: Department of Pathology, Armand Trousseau Hospital, Public Assistance-Hospitals of Paris, Paris, France.
authors: Sabah
authors: S
authors: Boudjemaa
authors: Paris Diderot University, Sorbonne Paris Cité, Public Assistance-Hospitals of Paris, Lariboisière Hospital, Emergency Services, Paris, France.
authors: Anthony
authors: A
authors: Chauvin
authors: Department of Radiology, Robert Debré Hospital, Public Assistance-Hospitals of Paris, Paris, France.
authors: Monique
authors: M
authors: Elmaleh
authors: Pediatric Department, Gustave Roussy Institute, Grand Campus, Villejuif, France.
authors: Brice
authors: B
authors: Fresneau
authors: Hematology and Oncology Department, Armand Trousseau Hospital, Public Assistance-Hospitals of Paris, Paris, France.
authors: Sylvie
authors: S
authors: Fasola
authors: Pediatric Ear, Nose, and Throat Department, Necker Hospital for Sick Children, Public Assistance-Hospitals of Paris, Paris, France.
authors: Erea-Noël
authors: EN
authors: Garabédian
authors: Pediatric Ear, Nose, and Throat Department, Robert Debré Hospital, Public Assistance-Hospitals of Paris, Paris, France.
authors: Thierry
authors: T
authors: Van Den Abeele
authors: Pediatric, Adolescent, and Young Adult Department, Curie Institute, Paris, France.
authors: Daniel
authors: D
authors: Orbach
mesh_terms: D000293:Adolescent; D002648:Child; D003937:Diagnosis, Differential; D005260:Female; D005602:France / Q000453:epidemiology; D006801:Humans; D015994:Incidence; D008297:Male; D009367:Neoplasm Staging; D012189:Retrospective Studies; D012468:Salivary Gland Neoplasms / Q000175:diagnosis* / Q000453:epidemiology / Q000473:pathology / Q000628:therapy*; D016896:Treatment Outcome
keywords: Salivary gland carcinomas; childhood rare tumors; retrospective study