title: Polycyclic Aromatic Hydrocarbons and Polychlorinated Dibenzo-p-Dioxins/Dibenzofurans in Microliter Samples of Human Serum as Exposure Indicators.
abstract: The objectives were: 1) measure polycyclic aromatic hydrocarbons (PAHs), polychlorinated dibenzo-p-dioxins (PCDDs) and dibenzofurans (PCDFs) in 100 μL of human serum and 2) assess PAH and PCDD/PCDF as markers of burn pit exposures during military deployments.
  
  
  
  PAHs and PCDDs/PCDFs were analyzed in 100 μL serum samples collected pre- and post-deployment from 200 persons deployed to Iraq or Afghanistan (CASE); 200 persons not deployed (CONTROL) with gas chromatography/mass spectrometry.
  
  
  
  Naphthalene was found in ∼83% of the samples and was statistically different between post-deployment CASE personnel and pre-deployment. 1,2,3,4,6,7,8-Heptachlorodibenzo-p-dioxin, Octachlorodibenzo-p-dioxin, 1,2,3,7,8,9-Hexachlorodibenzofuran, and 1,2,3,4,6,7,8-Heptachlorodibenzofuran were found in ∼38% of samples. Concentrations were significantly different between CASE and CONTROL and between pre- and post-deployment samples.
  
  
  
  PAH and PCDD/PCDF in serum can serve as exposure markers and measurements in small volumes is feasible for quantifying exposure to burn pits.
authors: Center for Air Resources Engineering and Science (Dr Xia, Ms Carroll-Haddad, and Dr Hopke), Clarkson University, Potsdam, New York; ALS Life Sciences Division, Environmental (Ms Brown), Houston, Texas; Departments of Medicine and Environmental Medicine (Dr Utell), University of Rochester Medical Center, New York; Professor, Department of Preventive Medicine and Biostatistics, Uniformed Services University of the Health Sciences (Dr Mallon), 4301 Jones Bridge Road, Bethesda, MD 20814.
authors: Xiaoyan
authors: X
authors: Xia
authors: Alesia
authors: A
authors: Carroll-Haddad
authors: Nicole
authors: N
authors: Brown
authors: Mark J
authors: MJ
authors: Utell
authors: Col Timothy M
authors: CT
authors: Mallon
authors: Philip K
authors: PK
authors: Hopke
mesh_terms: D000395:Air Pollutants, Occupational; D000072318:Dibenzofurans / Q000097:blood*; D004781:Environmental Exposure / Q000032:analysis*; D006801:Humans; D017745:Incineration; D007493:Iraq; D008889:Military Personnel; D016273:Occupational Exposure / Q000032:analysis*; D011078:Polychlorinated Biphenyls; D000072317:Polychlorinated Dibenzodioxins / Q000097:blood*; D011084:Polycyclic Aromatic Hydrocarbons / Q000097:blood*
chemical_list: D000395:Air Pollutants, Occupational; D000072318:Dibenzofurans; D000072317:Polychlorinated Dibenzodioxins; D011084:Polycyclic Aromatic Hydrocarbons; D011078:Polychlorinated Biphenyls; C046839:1,2,3,4,6,7,8-heptachlorodibenzodioxin