title: A role for auto-immunity in chronic rhinosinusitis? Lessons learned from sub-epidermal bullous disorders of the skin.
abstract: Chronic rhinosinusitis (CRS) is a frequent chronic condition, which has origins in complex interactions between genetic, immunological and microbial factors. The role of auto-immunity in CRS remains unclear, although recent studies have started to emerge in CRS patient refractory to maximal medical management. We discuss the possible auto-immunity link between CRS and other skin diseases, in particular acquired bullous dermatoses, and review the current evidence. We raise additional considerations for auto-immunity from both research and clinical standpoints.
authors: Faculté de Médecine, Université de Montréal, Montreal, QC Canada.
authors: Philippe
authors: P
authors: Lefrançois
authors: Centre Hospitalier de l'Université de Montréal (CHUM), Université de Montréal, Montreal, QC Canada.
authors: Hugo
authors: H
authors: Chapdelaine
authors: Centre Hospitalier de l'Université de Montréal (CHUM), Université de Montréal, Montreal, QC Canada.
authors: Benoît
authors: B
authors: Côté
authors: Centre Hospitalier de l'Université de Montréal (CHUM), Université de Montréal, Montreal, QC Canada ; Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), Université de Montréal, Montreal, QC Canada.
authors: Martin
authors: M
authors: Desrosiers
keywords: Auto-immunity; Blistering skin disorders; Bullous pemphigoid; Chronic rhinosinusitis; IgE