title: The pre-treatment neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, and red cell distribution width predict prognosis in patients with laryngeal carcinoma.
abstract: The aim of this study was to identify the potential prognostic roles of the preoperative neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and red cell distribution width (RDW) in patients with laryngeal squamous cell carcinoma (LSCC). 81 patients who underwent surgery for the larynx carcinoma were enrolled in the study. NLR, PLR and RDW were used as outcome measures. Local recurrence was detected in 30 (37.0 %) patients and neck lymph node metastasis was detected 6 (7.4 %) patients during follow-up period. Mortality was seen in 7 (8.6 %) patients. The mean PLR in the T1 and T2 stage tumors were significantly lower than the T4 stage. The mean RDW and PLR were significantly higher in the exitus group than the survivor group. The mean NLR in the patients with local recurrence was significantly higher than the non-recurrent patients. Progression-free survival (PFS) was lower in patients with high NLR. When analyzed by the Cox regression analysis of factors affecting the local recurrence, NLR was found to significantly affect the recurrence. According to ROC analysis for mortality, NLR was not found to be a prognostic factor, although the PLR and RDW were significant prognostic factors. According to Cox regression analysis, a high PLR increases mortality 4.2 times and a high RDW 4.6 times. Although in univariate analysis MCV, RDW and tumor grade were predictors of mortality, RDW and tumor grade independent predictors were found. Further studies involving large patient groups are required.
authors: Department of Otorhinolaryngology, Faculty of Medicine, Canakkale Onsekiz Mart University, Canakkale, Turkey. medinekara@gmail.com.
authors: Medine
authors: M
authors: Kara
authors: Department of Biochemistry, Faculty of Medicine, Canakkale Onsekiz Mart University, Canakkale, Turkey.
authors: Sema
authors: S
authors: Uysal
authors: Department of Anesthesiology and Reanimation, Faculty of Medicine, Canakkale Onsekiz Mart University, Canakkale, Turkey.
authors: Uğur
authors: U
authors: Altinişik
authors: Department of Public Health, Faculty of Medicine, Çanakkale Onsekiz Mart University, Canakkale, Turkey.
authors: Sibel
authors: S
authors: Cevizci
authors: Department of Otorhinolaryngology, Faculty of Medicine, Canakkale Onsekiz Mart University, Canakkale, Turkey.
authors: Oğuz
authors: O
authors: Güçlü
authors: Department of Otorhinolaryngology, Faculty of Medicine, Canakkale Onsekiz Mart University, Canakkale, Turkey.
authors: Fevzi Sefa
authors: FS
authors: Dereköy
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000097:blood* / Q000473:pathology / Q000601:surgery; D018572:Disease-Free Survival; D004909:Erythrocyte Indices; D005260:Female; D006801:Humans; D007822:Laryngeal Neoplasms / Q000097:blood* / Q000473:pathology / Q000601:surgery; D007958:Leukocyte Count; D008207:Lymphatic Metastasis; D008214:Lymphocytes / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000473:pathology; D009504:Neutrophils / Q000473:pathology*; D010976:Platelet Count; D011379:Prognosis; D012372:ROC Curve; D012189:Retrospective Studies
keywords: Larynx carcinoma; Neutrophil-to-lymphocyte ratio; Platelet-to-lymphocyte ratio; Prognosis; Red cell distribution width