title: Data on characterizing the gene expression patterns of neuronal ceroid lipofuscinosis genes: CLN1, CLN2, CLN3, CLN5 and their association to interneuron and neurotransmission markers: Parvalbumin and Somatostatin.
abstract: The article contains raw and analyzed data related to the research article "Neuronal ceroid lipofuscinosis genes, CLN2, CLN3, CLN5 are spatially and temporally co-expressed in a developing mouse brain" (Fabritius et al., 2014) [1]. The processed data gives an understanding of the development of the cell types that are mostly affected by defective function of CLN proteins, timing of expression of CLN1, CLN2, CLN3 and CLN5 genes in a murine model. The data shows relationship between the expression pattern of these genes during neural development. Immunohistochemistry was used to identify known interneuronal markers for neurotransmission and cell proliferation: parvalbumin, somatostatin subpopulations of interneurons. Non-radioactive in-situ hybridization detected CLN5 mRNA in the hippocampus. Throughout the development strong expression of CLN genes were identified in the germinal epithelium and in ventricle regions, cortex, hippocampus, and cerebellum. This provides supportive evidence that CLN1, CLN2, CLN3 and CLN5 genes may be involved in synaptic pruning.
authors: Department of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.
authors: Helena M
authors: HM
authors: Minye
authors: Department of Applied Biology, University of Helsinki, Finland; Department of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.
authors: Anna-Liisa
authors: AL
authors: Fabritius
authors: Department of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.
authors: Jouni
authors: J
authors: Vesa
authors: Department of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, CA, USA; Department of Molecular Medicine, Biomedicum, National Public Health Institute, PO Box 104, FIN 00300 Helsinki, Finland.
authors: Leena
authors: L
authors: Peltonen
keywords: CLN genes; CLN1/CLN2/CLN3/CLN5; Embryonic neurogenesis; Neurogenetics; Neuronal ceroid lipofuscinoses; Neuronal differentiation, neuroplasticity, and synaptic pruning; Neurotransmission, molecular genetics