title: Antioxidants in neoplastic cells: IV. Evidence that the phenolic antioxidant A274 is 9-(4-hydroxyphenyl)xanthene, an artifact in tissue culture media.
abstract: An extensively conjugated phenol (A274), recently shown to be present as a common trace constituent in randomly selected batches of commercial tissue culture media, was diazomethylated; the monomethyl derivative so prepared was shown to exhibit gas chromatographic and mass spectrometric properties identical to those observed for synthetically prepared 9-(4-methoxyphenyl)xanthene, but different from those of several isomeric compounds. The structure 9-(4-hydroxyphenyl)xanthene is thus proposed for A274.
authors: Medical and Health Sciences Division, Oak Ridge Associated Universities, PO Box 117, 37830, Oak Ridge, TN.
authors: R M
authors: RM
authors: Arneson
authors: Department of Chemistry, University of Georgia, 30602, Athens, GA.
authors: J L
authors: JL
authors: Hinds
authors: Department of Chemistry, University of Georgia, 30602, Athens, GA.
authors: J D
authors: JD
authors: Wander