title: Evaluation of Antioxidant, Anticholinesterase, and Antidiabetic Potential of Dry Leaves and Stems in Tamarix aphylla Growing Wild in Tunisia.
abstract: Tamarix aphylla (L.) Karst. has a wide geographic distribution and was employed in traditional medicine as astringent, anti-rheumatic and to treat fever. T. aphylla leaves and stems extracts were studied from both chemical and biological points of view to assess the antidiabetic, anticholinesterase and antioxidant potential of this species. The HPLC/Diode Array Detector (DAD) analysis showed the presence of 14 phenolic compounds (gallic, caffeic, p-coumaric, ferulic and ellagic acids, kaempferol, quercetin, quercetin 3-O-galactoside and six flavonol derivatives). This is the first study reporting a comparative study of the biological activities of different extracts from T. aphylla. High activities were obtained against DPPH radical, superoxide anion radical (O2∙-) and nitric oxide radical (•NO) in a concentration-dependent manner, the most active extracts being the polar ones. T. aphylla also showed moderate protective effects against acetylcholinesterase, but no effects were observed against butyrylcholinesterase. Against α-glucosidase the MeOH extracts displayed IC50values from 8.41 to 24.81 μg/ml.
authors: Research Unit of Applied Chemistry and Environment (UR13ES63), Faculty of Sciences of Monastir, Avenue de l'Environnement, 5019, Monastir, Tunisia.|Faculty of Sciences of Bizerte, University of Carthage, Carthage, Tunisia.
authors: Adel
authors: A
authors: Mahfoudhi
authors: REQUIMTE/LAQV, Laboratório de Farmacognosia, Departamento de Química, Faculdade de Farmácia da Universidade do Porto, Rua de Jorge Viterbo Ferreira, No. 228, 4050-313, Porto, Portugal.
authors: Clara
authors: C
authors: Grosso
authors: REQUIMTE/LAQV, Laboratório de Farmacognosia, Departamento de Química, Faculdade de Farmácia da Universidade do Porto, Rua de Jorge Viterbo Ferreira, No. 228, 4050-313, Porto, Portugal.
authors: Rui F
authors: RF
authors: Gonçalves
authors: Laboratory of Microbial Ecology and Technology (LR05ES08), National Institute of Applied Sciences and Technology, 2 Boulevard de la Terre, B.P. 676, 1080, Tunis, Tunisia.
authors: Eltaief
authors: E
authors: Khelifi
authors: Research Unit of Applied Chemistry and Environment (UR13ES63), Faculty of Sciences of Monastir, Avenue de l'Environnement, 5019, Monastir, Tunisia.
authors: Saoussen
authors: S
authors: Hammami
authors: Laboratory of Bioressources, Integrative Biology and Valorization, (LR14ES06), Higher Institute of Biotechnology of Monastir, Avenue Tahar Hadded, B. P. 74, 5000, Monastir, Tunisia.
authors: Sami
authors: S
authors: Achour
authors: Applications Laboratory of Chemical and Natural Resources and Environment (LR05ES09), Faculty of Sciences of Bizerte, 7021, Jarzouna, Tunisia.
authors: Malika
authors: M
authors: Trabelsi-Ayadi
authors: REQUIMTE/LAQV, Laboratório de Farmacognosia, Departamento de Química, Faculdade de Farmácia da Universidade do Porto, Rua de Jorge Viterbo Ferreira, No. 228, 4050-313, Porto, Portugal.
authors: Patrícia
authors: P
authors: Valentão
authors: REQUIMTE/LAQV, Laboratório de Farmacognosia, Departamento de Química, Faculdade de Farmácia da Universidade do Porto, Rua de Jorge Viterbo Ferreira, No. 228, 4050-313, Porto, Portugal.
authors: Paula B
authors: PB
authors: Andrade
authors: Research Unit of Applied Chemistry and Environment (UR13ES63), Faculty of Sciences of Monastir, Avenue de l'Environnement, 5019, Monastir, Tunisia.
authors: Zine
authors: Z
authors: Mighri
mesh_terms: D000110:Acetylcholinesterase / Q000378:metabolism*; D000975:Antioxidants / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D002800:Cholinesterase Inhibitors / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005609:Free Radicals / Q000037:antagonists & inhibitors; D007004:Hypoglycemic Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D018515:Plant Leaves / Q000737:chemistry; D018547:Plant Stems / Q000737:chemistry; D013329:Structure-Activity Relationship; D032363:Tamaricaceae / Q000737:chemistry* / Q000254:growth & development; D014416:Tunisia; D000520:alpha-Glucosidases / Q000378:metabolism*
chemical_list: D000975:Antioxidants; D002800:Cholinesterase Inhibitors; D005609:Free Radicals; D007004:Hypoglycemic Agents; D000110:Acetylcholinesterase; D000520:alpha-Glucosidases
keywords: 
  Tamarix aphylla
  ; Anticholinesterase; Free radicals; Phenolic composition; α-Glucosidase