title: Selection of an early biomarker for vascular normalization using dynamic contrast-enhanced ultrasonography to predict outcomes of metastatic patients treated with bevacizumab.
abstract: Dynamic contrast-enhanced ultrasonography (DCE-US) has been used for evaluation of tumor response to antiangiogenic treatments. The objective of this study was to assess the link between DCE-US data obtained during the first week of treatment and subsequent tumor progression.
  
  
  
  Patients treated with antiangiogenic therapies were included in a multicentric prospective study from 2007 to 2010. DCE-US examinations were available at baseline and at day 7. For each examination, a 3 min perfusion curve was recorded just after injection of a contrast agent. Each perfusion curve was modeled with seven parameters. We analyzed the correlation between criteria measured up to day 7 on freedom from progression (FFP). The impact was assessed globally, according to tumor localization and to type of treatment.
  
  
  
  The median follow-up was 20 months. The mean transit time (MTT) evaluated at day 7 was the only criterion significantly associated with FFP (P = 0.002). The cut-off point maximizing the difference between FFP curves was 12 s. Patients with at least a 12 s MTT had a better FFP. The results according to tumor type were significantly heterogeneous: the impact of MTT on FFP was more marked for breast cancer (P = 0.004) and for colon cancer (P = 0.025) than for other tumor types. Similarly, the differences in FFP according to MTT at day 7 were marked (P = 0.004) in patients receiving bevacizumab.
  
  
  
  The MTT evaluated with DCE-US at day 7 is significantly correlated to FFP of patients treated with bevacizumab. This criterion might be linked to vascular normalization.
  
  
  
  2007-A00399-44.
authors: Gustave Roussy, Université Paris-Saclay, Imaging Department, Villejuif, and IR4M, Centre National de la Recherche Scientifique, Université Paris-Sud, Université Paris-Saclay, Villejuif nathalie.lassau@gustaveroussy.fr.
authors: N
authors: N
authors: Lassau
authors: Gustave Roussy, Université Paris-Saclay, Imaging Department, Villejuif, and IR4M, Centre National de la Recherche Scientifique, Université Paris-Sud, Université Paris-Saclay, Villejuif.
authors: B
authors: B
authors: Coiffier
authors: Imaging Department, Institut Bergonié, Bordeaux.
authors: M
authors: M
authors: Kind
authors: Radiology Department, Assistance Publique-Hôpitaux de Paris, Hôpital Beaujon, Clichy.
authors: V
authors: V
authors: Vilgrain
authors: Radiology Department, Centre François Baclesse, Caen.
authors: J
authors: J
authors: Lacroix
authors: Radiology Department, Centre Léon Bérard, Lyon.
authors: M
authors: M
authors: Cuinet
authors: Radiology Department, Centre Oscar Lambret, Lille.
authors: S
authors: S
authors: Taieb
authors: Radiodiagnostics Department, Centre Claudius Regaud, Toulouse.
authors: R
authors: R
authors: Aziza
authors: Imaging Department, Institut Paoli Calmettes, Marseille.
authors: A
authors: A
authors: Sarran
authors: Radiodiagnostics Department, Centre René Gauducheau, ICO Nantes.
authors: C
authors: C
authors: Labbe-Devilliers
authors: Department of Abdominal and Digestive Imaging, Hôpital Saint-Eloi, Montpellier and Department of Radiology, McGill University Health Center, Montreal, Canada.
authors: B
authors: B
authors: Gallix
authors: Radiology Department, CHU La Pitié-Salpêtrière, Paris.
authors: O
authors: O
authors: Lucidarme
authors: Radiodiagnostics Department, Centre Jean Perrin, Clermont-Ferrand.
authors: Y
authors: Y
authors: Ptak
authors: Radiology Department, CHU Bicêtre, Le Kremlin-Bicêtre.
authors: L
authors: L
authors: Rocher
authors: Radiodiagnostics and Imaging Department, Institut Jean Godinot, Reims.
authors: L M
authors: LM
authors: Caquot
authors: Radiology Department, Hôpital Ambroise Paré, Boulogne-Billancourt.
authors: S
authors: S
authors: Chagnon
authors: Radiology Department, CHU Hôtel-Dieu, Lyon.
authors: D
authors: D
authors: Marion
authors: Radiology Department, CHU Henri Mondor, Créteil.
authors: A
authors: A
authors: Luciani
authors: Radiology Department, Centre Georges-François Leclerc, Dijon.
authors: S
authors: S
authors: Feutray
authors: Radiology Department, Hôpital Cochin, Paris.
authors: J
authors: J
authors: Uzan-Augui
authors: Gustave Roussy, Université Paris-Saclay, Imaging Department, Villejuif, and IR4M, Centre National de la Recherche Scientifique, Université Paris-Sud, Université Paris-Saclay, Villejuif.
authors: B
authors: B
authors: Benatsou
authors: Service biostatistique et épidémiologie, Gustave Roussy and CESP Centre for Research in Epidemiology and Population Health, INSERM U1018, Paris-Sud Univ., Villejuif, France.
authors: J
authors: J
authors: Bonastre
authors: Service biostatistique et épidémiologie, Gustave Roussy and CESP Centre for Research in Epidemiology and Population Health, INSERM U1018, Paris-Sud Univ., Villejuif, France.
authors: S
authors: S
authors: Koscielny
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D020533:Angiogenesis Inhibitors / Q000008:administration & dosage; D000068258:Bevacizumab / Q000008:administration & dosage*; D014408:Biomarkers, Tumor; D003287:Contrast Media / Q000008:administration & dosage; D005260:Female; D005602:France; D006801:Humans; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000000981:diagnostic imaging* / Q000188:drug therapy* / Q000473:pathology; D014463:Ultrasonography / Q000379:methods*
chemical_list: D020533:Angiogenesis Inhibitors; D014408:Biomarkers, Tumor; D003287:Contrast Media; D000068258:Bevacizumab
keywords: bevacizumab; breast cancer; colon cancer; dynamic contrast-enhanced ultrasonography (DCE-US); early evaluation; imaging biomarker