title: Anti-Müllerian hormone for prediction of ovarian response in Chinese infertile women undergoing IVF/ICSI cycles: a prospective, multi-centre, observational study.
abstract: This study explored the correlation between serum anti-Müllerian hormone (AMH) concentration and the number of retrieved oocytes after ovarian stimulation in Chinese infertile women undergoing assisted reproductive technology treatment and AMH cut-off values predicting low and high ovarian response. This was a prospective, multi-centre, observational study. A total of 615 subjects were included in nine assisted reproductive centres in China for outcome analysis. Subjects received assisted reproductive technology treatment and used recombinant human FSH (r-HFSH) or r-HFSH plus recombinant LH (rLH) for ovarian stimulation according to conventional treatment regimens. The main outcome variables were correlations between AMH and the number of retrieved oocytes and the cut-off values of AMH predicting low and high ovarian response. Serum AMH concentration was positively correlated with the number of oocytes retrieved in Chinese infertile women treated with IVF/intracytoplasmic sperm injection (ICSI) (Pearson correlation coefficient = 0.4754, P < 0.0001). The optimal AMH cut-off value was 2.6 ng/ml (sensitivity: 81.28%, specificity: 59.51%) in predicting high and normal response, and 1.1 ng/ml (sensitivity: 52.27%, specificity: 87.23%) in predicting low and normal response. In conclusion, serum AMH concentration can be used as a biomarker to predict ovarian response in Chinese infertile women treated with assisted reproductive technology.
authors: The Center of Reproductive Medicine, Peking University Third Hospital, Beijing, China.
authors: Rong
authors: R
authors: Li
authors: The Center of Reproductive Medicine, Reproductive and Genetic Hospital of CITIC-Xiangya, Changsha, China.
authors: Fei
authors: F
authors: Gong
authors: The Center of Reproductive Medicine, Women's Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
authors: Yimin
authors: Y
authors: Zhu
authors: Medical affairs, Merck Serono Co., Ltd., Beijing, China.
authors: Wenhui
authors: W
authors: Fang
authors: The Center of Reproductive Medicine, Renmin Hospital of Wuhan University, Wuhan, China.
authors: Jing
authors: J
authors: Yang
authors: The Center of Reproductive Medicine, Jiangsu Province Hospital, Nanjing, China.
authors: Jiayin
authors: J
authors: Liu
authors: The Center of Reproductive Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
authors: Linli
authors: L
authors: Hu
authors: The Center of Reproductive Medicine, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China.
authors: Dongzi
authors: D
authors: Yang
authors: The Center of Reproductive Medicine, The Sixth Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.
authors: Xiaoyan
authors: X
authors: Liang
authors: The Center of Reproductive Medicine, Peking University Third Hospital, Beijing, China. Electronic address: jie.qiao@263.net.
authors: Jie
authors: J
authors: Qiao
mesh_terms: D000328:Adult; D054304:Anti-Mullerian Hormone / Q000097:blood*; D002681:China; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D007247:Infertility, Female / Q000097:blood / Q000628:therapy*; D054315:Oocyte Retrieval; D010062:Ovulation Induction / Q000379:methods*; D011446:Prospective Studies; D020554:Sperm Injections, Intracytoplasmic; D016896:Treatment Outcome
chemical_list: D054304:Anti-Mullerian Hormone
keywords: AMH cut-off values; assisted reproductive technology; number of oocytes; ovarian response