title: Pulmonary involvement in systemic sclerosis.
abstract: Systemic sclerosis (SSc) is a multi-systemic autoimmune disease that mainly affects the skin, lungs, gastrointestinal tract, heart and kidneys. Pulmonary disease in patients with SSc is strongly associated with mortality. The mechanisms involved into its pathophysiology include the activation of autoimmune cells and hyperplasia of fibroblasts with an increased capacity to produce collagen and diminished collagen breakdown. Although pulmonary biopsy is the gold standard for the diagnosis of interstitial lung disease in SSc, the most commonly used method is high-resolution computed tomography due to its high sensitivity and specificity. Herein, a comprehensive review on the pulmonary involvement in SSc is presented highlighting the radiologic-pathologic correlations.
authors: Center for Autoimmune Diseases Research (CREA), School of Medicine and Health Sciences, Universidad del Rosario, Carrera 24 No. 63-C-69, Bogotá, Colombia.
authors: Adriana
authors: A
authors: Morales-Cárdenas
authors: Center for Autoimmune Diseases Research (CREA), School of Medicine and Health Sciences, Universidad del Rosario, Carrera 24 No. 63-C-69, Bogotá, Colombia.
authors: Camila
authors: C
authors: Pérez-Madrid
authors: Mederi, Hospital Universitario Mayor, Calle 24 No. 29-45, Bogotá, Colombia.
authors: Liliana
authors: L
authors: Arias
authors: Hospital Santa Clara ESE, CRA 14 B No. 1-45 Sur, Bogotá, Colombia.
authors: Paulina
authors: P
authors: Ojeda
authors: Center for Autoimmune Diseases Research (CREA), School of Medicine and Health Sciences, Universidad del Rosario, Carrera 24 No. 63-C-69, Bogotá, Colombia.
authors: María Paula
authors: MP
authors: Mahecha
authors: Center for Autoimmune Diseases Research (CREA), School of Medicine and Health Sciences, Universidad del Rosario, Carrera 24 No. 63-C-69, Bogotá, Colombia.
authors: Adriana
authors: A
authors: Rojas-Villarraga
authors: Mederi, Hospital Universitario Mayor, Calle 24 No. 29-45, Bogotá, Colombia.
authors: Jorge A
authors: JA
authors: Carrillo-Bayona
authors: Center for Autoimmune Diseases Research (CREA), School of Medicine and Health Sciences, Universidad del Rosario, Carrera 24 No. 63-C-69, Bogotá, Colombia. Electronic address: juan.anaya@urosario.edu.co.
authors: Juan-Manuel
authors: JM
authors: Anaya
mesh_terms: D005260:Female; D006801:Humans; D008168:Lung / Q000473:pathology; D017563:Lung Diseases, Interstitial / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000209:etiology / Q000276:immunology; D008297:Male; D012595:Scleroderma, Systemic / Q000150:complications*; D014057:Tomography, X-Ray Computed
keywords: Pathology; Pulmonary involvement; Radiology; Systemic sclerosis; Tomography; X-ray computed