title: Autopsy of anaplastic carcinoma of the pancreas producing granulocyte colony-stimulating factor.
abstract: A 50-year-old man presented to a nearby hospital with high fever and anorexia. An abdominal tumor was detected, and he was referred to our hospital. A pancreatic tumor was detected by computed tomography and abdominal ultrasonography. He had high fever, leukocytosis, and high serum granulocyte colony-stimulating factor (G-CSF). We performed a tumor biopsy and histological examination revealed anaplastic carcinoma of the pancreas. Based on the diagnosis, we initiated chemotherapy using gemcitabine plus S-1. However, the tumor rapidly progressed and he deteriorated and died 123 days after admission. As immunohistochemical study showed positive staining for G-CSF in the tumor cell, we diagnosed the tumor producing G-CSF during autopsy. Anaplastic carcinoma of the pancreas producing G-CSF is very rare, with 10 cases, including ours, reported in the literature.
authors: Department of General Medicine, Hiroshima Memorial Hospital.
authors: Haruna
authors: H
authors: Hayashi
authors: Noriaki
authors: N
authors: Eguchi
authors: Kyoku
authors: K
authors: Sumimoto
authors: Kenta
authors: K
authors: Matsumoto
authors: Takahiro
authors: T
authors: Azakami
authors: Tomonori
authors: T
authors: Sumida
authors: Tadamasa
authors: T
authors: Tamura
authors: Masaharu
authors: M
authors: Sumii
authors: Naohiro
authors: N
authors: Uraoka
authors: Fumio
authors: F
authors: Shimamoto
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001344:Autopsy; D001706:Biopsy; D002277:Carcinoma / Q000000981:diagnostic imaging* / Q000188:drug therapy / Q000473:pathology; D003841:Deoxycytidine / Q000008:administration & dosage / Q000031:analogs & derivatives; D004338:Drug Combinations; D016179:Granulocyte Colony-Stimulating Factor / Q000096:biosynthesis*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010094:Oxonic Acid / Q000008:administration & dosage; D010190:Pancreatic Neoplasms / Q000000981:diagnostic imaging* / Q000188:drug therapy / Q000473:pathology; D005641:Tegafur / Q000008:administration & dosage; D014057:Tomography, X-Ray Computed; D000093542:Gemcitabine
chemical_list: D004338:Drug Combinations; D003841:Deoxycytidine; D016179:Granulocyte Colony-Stimulating Factor; C079198:S 1 (combination); D005641:Tegafur; D010094:Oxonic Acid; D000093542:Gemcitabine