title: [Wernicke-Korsakoff syndrome].
abstract: OBJECTIVE
  To study the diagnosis and treatment of non-alcoholic Wernicke-Korsakoff syndrome (WKS).
  
  
  METHODS
  Eight patients (5 men and 3 women), mean age 38,9±1,4 years, with WKS developed due to acute gastrointestinal tract (GIT) disease (3 patients), the exacerbation of chronic GIT disease with malabsorption (2 patients) and after surgery on the upper GIT (3 patients) were included in the study.
  
  
  RESULTS
  The disease manifested with consciousness disturbance, symptoms of ataxia, eye movement disorders and bulbar syndrome that developed after 24-48 h. Treatment resistant tonic-clonic seizures were developed in 1 patient. MRI revealed hyper intensive signals on T2-weighted images in the hypothalamus, mamillar bodies, brain stem, hippocampus as well as contrast accumulation in the mamillar bodies. Treatment with vitamin B complex (neurobion) and thiamine exerted a positive effect.
  
  
  CONCLUSIONS
  Patients with GIT disease with malabsorption are at risk of WKS. Consciousness disturbance, symptoms of ataxia, eye movement disorders indicate the necessity of treatment with thiamine that allows to prevent the development of stable cognitive deficit.
authors: M.F. Vladimirski Moscow Regional Research Institute, Moscow, Russia.
authors: S V
authors: SV
authors: Kotov
authors: M.F. Vladimirski Moscow Regional Research Institute, Moscow, Russia.
authors: A I
authors: AI
authors: Lobakov
authors: M.F. Vladimirski Moscow Regional Research Institute, Moscow, Russia.
authors: E V
authors: EV
authors: Isakova
authors: M.F. Vladimirski Moscow Regional Research Institute, Moscow, Russia.
authors: G A
authors: GA
authors: Stashuk
authors: M.F. Vladimirski Moscow Regional Research Institute, Moscow, Russia.
authors: T V
authors: TV
authors: Volchenkova
mesh_terms: D000328:Adult; D000368:Aged; D001921:Brain / Q000187:drug effects; D060825:Cognitive Dysfunction / Q000175:diagnosis; D005260:Female; D006801:Humans; D020915:Korsakoff Syndrome / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000209:etiology; D008279:Magnetic Resonance Imaging; D008286:Malabsorption Syndromes / Q000150:complications*; D008297:Male; D008875:Middle Aged; D013831:Thiamine / Q000627:therapeutic use*; D014803:Vitamin B Complex / Q000627:therapeutic use*; D055815:Young Adult
chemical_list: D014803:Vitamin B Complex; D013831:Thiamine