title: Differing patterns in intentional and unintentional poisonings among young people in England, 1998-2014: a population-based cohort study.
abstract: Accurate and up to date data on changes in poisoning incidence among young people are lacking. Recent linkage of UK primary care, hospital and mortality data allows these to be quantified to inform service delivery.
  
  
  
  An open cohort study of 1 736 527 young people aged 10-24 between 1998 and 2014 was conducted using linked data from the Clinical Practice Research Datalink, Hospital Episode Statistics and Office for National Statistics deaths. Incidence rates (IRs) by poisoning intent were calculated by age, sex, deprivation and year.
  
  
  
  Total poisoning IRs increased by 25% from 1998/99 to 2013/14 [adjusted incidence rate ratio (aIRR) 1.25, 95% CI: 1.20-1.30]. Patterns differed markedly by intent. Intentional poisoning rates increased by 52% while unintentional rates remained unchanged. Intentional rates increased almost exclusively among females, gradually between 1998/99 and 2013/14 among 16-18 (88% increase) and 19-24 (36% increase) year olds but only increased among 10-15 year olds in the last 2 years (79% increase). A 2-fold increased risk of poisoning for the most compared to least deprived quintile existed (aIRR 2.21, 95% CI: 2.02-2.23) and remained over time.
  
  
  
  Commissioning of primary and secondary prevention services needs to address the growing problem of intentional poisonings among young people.
authors: Division of Primary Care, School of Medicine, University of Nottingham, NottinghamNG7 2RD, UK.
authors: Edward G
authors: EG
authors: Tyrrell
authors: Division of Primary Care, School of Medicine, University of Nottingham, NottinghamNG7 2RD, UK.
authors: Elizabeth
authors: E
authors: Orton
authors: Division of Psychiatry & Applied Psychology, School of Medicine, University of Nottingham, NottinghamNG7 2UH, UK.
authors: Kapil
authors: K
authors: Sayal
authors: Division of Primary Care, School of Medicine, University of Nottingham, NottinghamNG7 2RD, UK.
authors: Ruth
authors: R
authors: Baker
authors: Division of Primary Care, School of Medicine, University of Nottingham, NottinghamNG7 2RD, UK.
authors: Denise
authors: D
authors: Kendrick
mesh_terms: D000293:Adolescent; D000294:Adolescent Behavior; D000328:Adult; D000367:Age Factors; D002648:Child; D015331:Cohort Studies; D062787:Drug Overdose / Q000453:epidemiology / Q000523:psychology*; D004739:England / Q000453:epidemiology; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D011041:Poisoning / Q000453:epidemiology* / Q000523:psychology*; D011159:Population Surveillance; D012307:Risk Factors; D016728:Self-Injurious Behavior / Q000453:epidemiology / Q000523:psychology*; D012737:Sex Factors; D013406:Suicide, Attempted / Q000523:psychology* / Q000706:statistics & numerical data / Q000639:trends*; D055815:Young Adult
keywords: epidemiology; mental health; young people