title: Nuclear receptors as pharmacological targets, where are we now?
abstract: Knowledge of integrative physiology is a major challenge for scientists, as even small deregulation could lead to diseases. Cells communicate with each other to control many processes such as growth, migration, survival, or differentiation. Such interaction could be achieved via several mechanisms either through cell-cell interactions and/or through the signaling of molecules that bind to receptors on the membrane or in the target cells. The produced molecules could have either autocrine, paracrine stimulations, or even act on distant organs (endocrine signaling).
authors: INSERM U 1103, Génétique Reproduction et Développement (GReD), Campus Universitaire des Cézeaux, 10 avenue Blaise Pascal, TSA 60026, CS 60026, 63178, Aubière Cedex, France. david.volle@inserm.fr.|Université Clermont Auvergne, GReD, 63000, Clermont-Ferrand, France. david.volle@inserm.fr.|Université Clermont Auvergne, GReD, 63170, Aubière, France. david.volle@inserm.fr.|CNRS, UMR 6293, GReD, 63170, Aubière, France. david.volle@inserm.fr.
authors: David H
authors: DH
authors: Volle
mesh_terms: D000818:Animals; D004194:Disease; D006801:Humans; D058990:Molecular Targeted Therapy; D005810:Multigene Family; D004364:Pharmaceutical Preparations / Q000378:metabolism; D018160:Receptors, Cytoplasmic and Nuclear / Q000378:metabolism*
chemical_list: D004364:Pharmaceutical Preparations; D018160:Receptors, Cytoplasmic and Nuclear
keywords: Nuclear receptors; Pathophysiology; Therapeutic drugs