title: Preparation and Antiproliferative Activity of Liposomes Containing a Combination of Cisplatin and Procainamide Hydrochloride.
abstract: We have previously reported the enhancement of the antiproliferative and apoptotic activities of cis-diamminedichloroplatinum(II) (DDP) when it is coadministered with a class I antiarrhythmic drug procainamide hydrochloride (PA). Here, we determined the antiproliferative activity of DDP, either in solution or loaded in liposomes, in the presence of PA, in the bulk solution, or directly embedded in liposomes together with DDP. Our results show that PA potentiates the activity of DDP-liposomes and that this effect is maintained at least in some of the investigated cell types when both drugs were mixed and loaded together into liposomes.
authors: IRCCS Azienda Ospedaliera Universitaria San Martino-IST Istituto Nazionale per la Ricerca sul Cancro, U.O.C. Bioterapie, 16132 Genova, Italy.
authors: Maurizio
authors: M
authors: Viale
authors: Dipartimento di Farmacia, Università 'G. d'Annunzio'di Chieti-Pescara , 66100 Chieti, Italy.
authors: Antonella
authors: A
authors: Fontana
authors: IRCCS Azienda Ospedaliera Universitaria San Martino-IST Istituto Nazionale per la Ricerca sul Cancro, U.O.C. Bioterapie, 16132 Genova, Italy.
authors: Irena
authors: I
authors: Maric
authors: IRCCS Azienda Ospedaliera Universitaria San Martino-IST Istituto Nazionale per la Ricerca sul Cancro, U.O.C. Bioterapie, 16132 Genova, Italy.
authors: Massimiliano
authors: M
authors: Monticone
authors: Dipartimento di Farmacia, Università 'G. d'Annunzio'di Chieti-Pescara , 66100 Chieti, Italy.
authors: Guido
authors: G
authors: Angelini
authors: Dipartimento di Farmacia, Università 'G. d'Annunzio'di Chieti-Pescara , 66100 Chieti, Italy.
authors: Carla
authors: C
authors: Gasbarri
mesh_terms: D000072283:A549 Cells; D000818:Animals; D049109:Cell Proliferation / Q000187:drug effects; D002945:Cisplatin / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004357:Drug Synergism; D020128:Inhibitory Concentration 50; D008081:Liposomes / Q000138:chemical synthesis / Q000737:chemistry*; D011342:Procainamide / Q000494:pharmacology*
chemical_list: D008081:Liposomes; D011342:Procainamide; D002945:Cisplatin