title: Neural Differentiation in the Third Dimension: Generating a Human Midbrain.
abstract: In recent years, technological improvements in three-dimensional (3D) culture systems have enabled the generation of organoids or spheroids representing a variety of tissues, including the brain. In this issue of Cell Stem Cell, Jo et al. (2016) describe a 3D culture model of the human midbrain containing dopaminergic neurons and neuromelanin.
authors: Graduate Program in Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA; Department of Psychiatry and Behavioral Sciences, Center for Sleep Sciences and Medicine, Stanford Neurosciences Institute and Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.
authors: Rebecca M
authors: RM
authors: Marton
authors: Department of Psychiatry and Behavioral Sciences, Center for Sleep Sciences and Medicine, Stanford Neurosciences Institute and Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA. Electronic address: spasca@stanford.edu.
authors: Sergiu P
authors: SP
authors: Paşca
mesh_terms: D001921:Brain; D002454:Cell Differentiation; D059290:Dopaminergic Neurons / Q000166:cytology*; D006801:Humans; D008636:Mesencephalon / Q000166:cytology*; D009940:Organoids / Q000166:cytology