title: The 3'UTR signature defines a highly metastatic subgroup of triple-negative breast cancer.
abstract: Triple-negative breast cancer (TNBC) is a highly heterogeneous disease with an aggressive clinical course. Prognostic models are needed to chart potential patient outcomes. To address this, we used alternative 3'UTR patterns to improve postoperative risk stratification. We collected 327 publicly available microarrays and generated the 3'UTR landscape based on expression ratios of alternative 3'UTR. After initial feature filtering, we built a 17-3'UTR-based classifier using an elastic net model. Time-dependent ROC comparisons and Kaplan-Meier analyses confirmed an outstanding discriminating power of our prognostic model for TNBC patients. In the training cohort, 5-year event-free survival (EFS) was 78.6% (95% CI 71.2-86.0) for the low-risk group, and 16.3% (95% CI 2.3-30.4) for the high-risk group (log-rank p<0.0001; hazard ratio [HR] 8.29, 95% CI 4.78-14.4), In the validation set, 5-year EFS was 75.6% (95% CI 68.0-83.2) for the low-risk group, and 33.2% (95% CI 17.1-49.3) for the high-risk group (log-rank p<0.0001; HR 3.17, 95% CI 1.66-5.42). In conclusion, the 17-3'UTR-based classifier provides a superior prognostic performance for estimating disease recurrence and metastasis in TNBC patients and it may permit personalized management strategies.
authors: Department of Breast Surgery, Fudan University Shanghai Cancer Center, Fudan University, Shanghai, China.|Key Laboratory of Breast Cancer in Shanghai, Fudan University Shanghai Cancer Center, Fudan University, Shanghai, China.|Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China.
authors: Lei
authors: L
authors: Wang
authors: Department of Breast Surgery, Fudan University Shanghai Cancer Center, Fudan University, Shanghai, China.|Key Laboratory of Breast Cancer in Shanghai, Fudan University Shanghai Cancer Center, Fudan University, Shanghai, China.|Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China.
authors: Xin
authors: X
authors: Hu
authors: Key Laboratory of Systems Biology, Shanghai Advanced Research Institute, Chinese Academy of Sciences, Shanghai, China.|School of Life Science and Technology, ShanghaiTech University, Shanghai, China.
authors: Peng
authors: P
authors: Wang
authors: Department of Breast Surgery, Fudan University Shanghai Cancer Center, Fudan University, Shanghai, China.|Key Laboratory of Breast Cancer in Shanghai, Fudan University Shanghai Cancer Center, Fudan University, Shanghai, China.|Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China.|Institutes of Biomedical Sciences, Fudan University, Shanghai, China.
authors: Zhi-Ming
authors: ZM
authors: Shao
mesh_terms: D020413:3' Untranslated Regions / Q000235:genetics*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015331:Cohort Studies; D003198:Computer Simulation; D005260:Female; D006801:Humans; D008875:Middle Aged; D009362:Neoplasm Metastasis; D009364:Neoplasm Recurrence, Local; D057285:Precision Medicine; D011379:Prognosis; D016019:Survival Analysis; D046888:Tissue Array Analysis; D064726:Triple Negative Breast Neoplasms / Q000175:diagnosis* / Q000235:genetics / Q000401:mortality
chemical_list: D020413:3' Untranslated Regions
keywords: 3′ untranslated region; alternative polyadenylation; biomarker; prognostic modeling; triple-negative breast cancer