title: Expression of vascular endothelial growth factor in normal pituitary cells and pituitary adenomas producing adrenocorticotropic hormone.
abstract: Vascular endothelial growth factor (VEGF) induces endothelial cell proliferation and an increase in capillary permeability. Because the anterior pituitary gland and pituitary adenomas are highly vascular, expression of VEGF was examined immunohistochemically. Some normal pituitary cells stained positively for VEGF, and restaining for ACTH, prolactin, TSH, LH, FSH, and S-100 protein after VEGF staining revealed that almost all cells staining positively for ACTH also stained for VEGF. Only adenomas staining positively for ACTH stained for VEGF. These results suggest that VEGF is produced by normal pituitary cells and adenomas producing ACTH.
authors: Department of Pathology, Osaka Medical Center for Cancer and Cardiovascular Diseases, 3-3, 1-Chome, Higashinari-ku, 537-8511, Osaka, Japan.
authors: T
authors: T
authors: Yamamoto
authors: Department of Pathology, Osaka Medical Center for Cancer and Cardiovascular Diseases, 3-3, 1-Chome, Higashinari-ku, 537-8511, Osaka, Japan.
authors: Y
authors: Y
authors: Nishizawa
authors: Department of Pathology, Itami City Hospital, Hyogo, Japan.
authors: M
authors: M
authors: Tsuji
authors: Department of Neurosurgery, Osaka University Medical School, Osaka, Japan.
authors: Y
authors: Y
authors: Saitoh
authors: Department of Pathology, Osaka Medical Center for Cancer and Cardiovascular Diseases, 3-3, 1-Chome, Higashinari-ku, 537-8511, Osaka, Japan.
authors: H
authors: H
authors: Funai
authors: Department of Pathology, Kitano Hospital, Osaka.
authors: T
authors: T
authors: Hirai
authors: Department of Pathology, Hyogo College of Medicine, Hyogo, Japan.
authors: A
authors: A
authors: Sugihara
authors: Department of Pathology, Hyogo College of Medicine, Hyogo, Japan.
authors: T
authors: T
authors: Tsujimura
authors: Department of Pathology, Hyogo College of Medicine, Hyogo, Japan.
authors: Y
authors: Y
authors: Nakata
authors: Department of Pathology, Osaka Medical Center for Cancer and Cardiovascular Diseases, 3-3, 1-Chome, Higashinari-ku, 537-8511, Osaka, Japan.
authors: S
authors: S
authors: Ishiguro
authors: Department of Pathology, Hyogo College of Medicine, Hyogo, Japan.
authors: N
authors: N
authors: Terada
keywords: ACTH, pituitary gland; Vascular endothelial growth factor; immunohistochemistry; pituitary adenoma; vascular permeability factor