title: [Temporomandibular disorders and Ehlers-Danlos syndrome, hypermobility type: A case-control study].
abstract: BACKGROUND
  The Ehlers-Danlos syndrome, hypermobility type (EDS-HT) is a rare genetic disease. Diagnosis is based on a combination of clinical criteria described in the classification of Villefranche. Diagnosis is difficult to make because of the lack of specific clinical signs and the absence of genetic testing. The EDS-TH manifests itself manly by musculoskeletal pain and joint hypermobility. Temporomandibular disorders (TMD) are also reported. Our aim was to objectify the presence and to qualify the type of TMD associated with the EDS-HT in order to propose an additional diagnostic argument.
  
  
  METHODS
  A prospective, monocenter case-control study, comparing a cohort of patients suffering from EDS-HT to a paired control group of healthy volunteers has been conducted. Clinical examination was standardized, including a general questioning, an oral examination and a temporomandibular joint examination following the TMD/RDC (temporomandibular disorders/research diagnostic criteria).
  
  
  RESULTS
  Fourteen EDS-HT patients and 58 control patients were examined. The prevalence of TMDs (n=13; 92.9% vs. n=4; 6.9%; P=10(-11)) was significantly higher in the EDS-HT group. TMDs occurring in the EDS-HT group were complex, combining several mechanisms in contrast to the control group, where only one mechanism was found in all the patients (n=13; 92.9% vs. n=0; 0.0%).
  
  
  CONCLUSIONS
  TMDs are strongly associated with RDS-HT. TMDs could therefore be used in the diagnosis of this disease.
authors: Service de chirurgie maxillo-faciale et plastique, CHU de Caen, avenue de la Côte-de-Nacre, 14000 Caen, France. Electronic address: diep-d@chu-caen.fr.
authors: D
authors: D
authors: Diep
authors: Service de chirurgie maxillo-faciale et plastique, CHU de Caen, avenue de la Côte-de-Nacre, 14000 Caen, France.
authors: V
authors: V
authors: Fau
authors: Service de chirurgie maxillo-faciale et plastique, CHU de Caen, avenue de la Côte-de-Nacre, 14000 Caen, France.
authors: S
authors: S
authors: Wdowik
authors: Service de médecine Interne, CHU de Caen, avenue de la Côte-de-Nacre, 14000 Caen, France.
authors: B
authors: B
authors: Bienvenu
authors: Service de chirurgie maxillo-faciale et plastique, CHU de Caen, avenue de la Côte-de-Nacre, 14000 Caen, France; Laboratoire EA 4652 microenvironnement cellulaire et pathologies, équipe BioconnecT, université de Caen-Basse-Normandie, esplanade de la Paix, 14032 Caen cedex 5, France; Faculté de médecine de Caen, université de Caen-Basse-Normandie, 2 rue des Rochambelles, 14032 Caen cedex 5, France.
authors: H
authors: H
authors: Bénateau
authors: Service de chirurgie maxillo-faciale et plastique, CHU de Caen, avenue de la Côte-de-Nacre, 14000 Caen, France; Laboratoire EA 4652 microenvironnement cellulaire et pathologies, équipe BioconnecT, université de Caen-Basse-Normandie, esplanade de la Paix, 14032 Caen cedex 5, France; Faculté de médecine de Caen, université de Caen-Basse-Normandie, 2 rue des Rochambelles, 14032 Caen cedex 5, France.
authors: A
authors: A
authors: Veyssière
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D004535:Ehlers-Danlos Syndrome / Q000150:complications* / Q000175:diagnosis / Q000453:epidemiology; D005260:Female; D006801:Humans; D007593:Joint Instability / Q000150:complications / Q000175:diagnosis / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D013705:Temporomandibular Joint Disorders / Q000150:complications* / Q000175:diagnosis / Q000453:epidemiology
keywords: Dysfonction de l’appareil manducateur; Ehlers-Danlos syndrome hypermobility type; Syndrome d’Ehlers-Danlos; Temporomandibular disorders