title: Solute Carriers in the Blood-Brain Barier: Safety in Abundance.
abstract: Blood-brain barrier formed by brain capillary endothelial cells, being in contact with astrocytes endfeet and pericytes, separates extracellular fluid from plasma. Supply of necessary nutrients and removal of certain metabolites takes place due to the activity of transporting proteins from ABC (ATP binding cassette) and SLC (solute carrier) superfamilies. This review is focused on the SLC families involved in transport though the blood-brain barrier of energetic substrates (glucose, monocarboxylates, creatine), amino acids, neurotransmitters and their precursors, as well as organic ions. Members of SLC1, SLC2, SLC3/SLC7, SLC5, SLC6, SLC16, SLC22, SLC38, SLC44, SLC47 and SLCO (SLC21), whose presence in the blood-brain barriers has been demonstrated are characterized with a special emphasis put on polarity of transporters localization in a luminal (blood side) versus an abluminal (brain side) membrane.
authors: Laboratory of Transport through Biomembranes, Department of Molecular and Cellular Neurobiology, Nencki Institute of Experimental Biology of Polish Academy of Sciences, 3 Pasteur Str., 02-093, Warsaw, Poland. k.nalecz@nencki.gov.pl.
authors: Katarzyna A
authors: KA
authors: Nałęcz
mesh_terms: D026905:Amino Acid Transport Systems / Q000378:metabolism*; D000818:Animals; D001812:Blood-Brain Barrier / Q000378:metabolism*; D004730:Endothelium, Vascular / Q000378:metabolism; D006801:Humans; D055806:Microvessels / Q000378:metabolism; D018377:Neurotransmitter Agents / Q000378:metabolism; D027361:Organic Anion Transporters / Q000378:metabolism*; D027701:Organic Cation Transport Proteins / Q000378:metabolism*; D000070590:Solute Carrier Proteins / Q000378:metabolism*
chemical_list: D026905:Amino Acid Transport Systems; D018377:Neurotransmitter Agents; D027361:Organic Anion Transporters; D027701:Organic Cation Transport Proteins; D000070590:Solute Carrier Proteins
keywords: Blood–brain barrier; Cell polarity; Membrane transport; Solute carriers (SLC)