title: The Synthesis of Multisubstituted Pyrroles via a Copper-Catalyzed Tandem Three-Component Reaction.
abstract: An unprecedented nucleophilic addition/cyclization/aromatization cascade of basic chemicals, i.e., aromatic alkenes/alkynes, trimethylsilyl cyanide and N,N-disubstituted formamide, has been developed to give a series of multisubstituted pyrroles in moderate to good yields with high regioselectivities. This reaction not only reveals a new reaction mode for α-aminonitriles, but also provides a new and efficient cyclization pattern for the synthesis of multisubstituted pyrroles as well as their derivatives, which might facilitate related biological studies.
authors: School of Pharmacy and State Key Laboratory of Applied Organic Chemistry, Lanzhou University , Lanzhou 730000, P. R. China.
authors: Xue-Qing
authors: XQ
authors: Mou
authors: School of Pharmacy and State Key Laboratory of Applied Organic Chemistry, Lanzhou University , Lanzhou 730000, P. R. China.
authors: Zheng-Liang
authors: ZL
authors: Xu
authors: School of Pharmacy and State Key Laboratory of Applied Organic Chemistry, Lanzhou University , Lanzhou 730000, P. R. China.
authors: Li
authors: L
authors: Xu
authors: School of Pharmacy and State Key Laboratory of Applied Organic Chemistry, Lanzhou University , Lanzhou 730000, P. R. China.
authors: Shao-Hua
authors: SH
authors: Wang
authors: School of Pharmacy and State Key Laboratory of Applied Organic Chemistry, Lanzhou University , Lanzhou 730000, P. R. China.
authors: Bang-Hong
authors: BH
authors: Zhang
authors: School of Pharmacy and State Key Laboratory of Applied Organic Chemistry, Lanzhou University , Lanzhou 730000, P. R. China.
authors: Di
authors: D
authors: Zhang
authors: School of Pharmacy and State Key Laboratory of Applied Organic Chemistry, Lanzhou University , Lanzhou 730000, P. R. China.
authors: Jie
authors: J
authors: Wang
authors: School of Pharmacy and State Key Laboratory of Applied Organic Chemistry, Lanzhou University , Lanzhou 730000, P. R. China.
authors: Wei-Ting
authors: WT
authors: Liu
authors: School of Pharmacy and State Key Laboratory of Applied Organic Chemistry, Lanzhou University , Lanzhou 730000, P. R. China.
authors: Wen
authors: W
authors: Bao