title: Chronic Eosinophilic Leukemia Presenting Predominantly with Cutaneous Manifestations.
abstract: A 37-year-old male presented with severe oral and genital mucosal ulcers, lichenoid eruption and twenty-nail dystrophy. Systemic examination was normal, except for anemia. On investigations, he was found to have persistently elevated peripheral eosinophilia, absolute eosinophil count >5000/mm(3), bone marrow showing increased eosinophilic precursors, and infiltration by atypical cells. The serum vitamin B12 levels were grossly elevated, and Philadelphia chromosome study was negative. Thus, a diagnosis of chronic eosinophilic leukemia was made. The patient showed excellent response to imatinib mesylate. We are reporting a rare type of leukemia presenting with predominantly cutaneous manifestations.
authors: Department of Dermatology and Venereology, Government Medical College, Thiruvananthapuram, Kerala, India.
authors: Suja
authors: S
authors: Vidyadharan
authors: Department of Dermatology and Venereology, Government Medical College, Thiruvananthapuram, Kerala, India.
authors: Bebisha
authors: B
authors: Joseph
authors: Department of Dermatology and Venereology, Government Medical College, Thiruvananthapuram, Kerala, India.
authors: Sukumaran Pradeep
authors: SP
authors: Nair
keywords: Chronic eosinophilic leukemia; lichen planus; twenty-nail dystrophy