title: Does the course of laboratory parameters help us to predict the outcome of CCHF?
abstract: OBJECTIVE
  This study was performed to identify the characteristics distinguishing fatal and nonfatal cases of patients diagnosed with Crimean-Congo hemorrhagic fever (CCHF).
  
  
  METHODS
  A total of 92 patients with confirmed diagnosis of CCHF in 2009-2013 were included in the study.
  
  
  RESULTS
  A high level of urea and aPTT on the third day of hospital stay, diarrhea, somnolence, and the interval from the beginning of the symptoms to hospital admission were independently associated with fatality. Each 10-unit increase in aPTT and urea levels increased the fatality rate by 3.379-fold and 1.236-fold, respectively. Delay in hospital admission increased the fatality rate 1.453-fold for each day of delay. When comparing first and third admission-day laboratory values, the increase in leukocyte counts and the decrease in CPK, urea, creatinine, aPTT, PT, INR, and hemoglobin levels were significant in nonfatal cases.
  
  
  CONCLUSIONS
  This study showed that the course of these laboratory tests helps us to predict the outcome of the disease. In a few days of hospitalization, persistence or progress of the abnormal laboratory parameters may warn us about poor prognosis.
authors: Department of Infectious Diseases and Clinical Microbiology, Niksar State Hospital, Tokat, Turkey.
authors: Sümeyye
authors: S
authors: Kazancioğlu
authors: Department of Infectious Diseases and Clinical Microbiology, Ankara Numune Research and Training Hospital, Ankara, Turkey.
authors: Esragül
authors: E
authors: Akinci
authors: Department of Infectious Diseases and Clinical Microbiology, Ankara Numune Research and Training Hospital, Ankara, Turkey.
authors: Aliye
authors: A
authors: Baştuğ
authors: Department of Infectious Diseases and Clinical Microbiology, Faculty of Medicine, Yıldırım Beyazıt University, Ankara, Turkey.
authors: Bircan
authors: B
authors: Kayaaslan
authors: Department of Infectious Diseases and Clinical Microbiology, Ankara Numune Research and Training Hospital, Ankara, Turkey.
authors: Ayşe
authors: A
authors: But
authors: Department of Infectious Diseases and Clinical Microbiology, Ankara Numune Research and Training Hospital, Ankara, Turkey.
authors: Halide
authors: H
authors: Aslaner
authors: Department of Infectious Diseases and Clinical Microbiology, Ankara Numune Research and Training Hospital, Ankara, Turkey.
authors: Selim Sırrı
authors: SS
authors: Eren
authors: Department of Infectious Diseases and Clinical Microbiology, Ankara Numune Research and Training Hospital, Ankara, Turkey.
authors: Meltem Arzu
authors: MA
authors: Yetkin
authors: Department of Infectious Diseases and Clinical Microbiology, Ankara Numune Research and Training Hospital, Ankara, Turkey.
authors: Hurrem
authors: H
authors: Bodur
mesh_terms: D003225:Hemorrhagic Fever Virus, Crimean-Congo; D006479:Hemorrhagic Fever, Crimean; D006760:Hospitalization; D006801:Humans; D010314:Partial Thromboplastin Time; D011379:Prognosis
keywords: Crimean–Congo hemorrhagic fever; mortality; severity criteria