title: Multicenter Experience With Catheter Ablation for Ventricular Tachycardia in Lamin A/C Cardiomyopathy.
abstract: Lamin A/C (LMNA) cardiomyopathy is a genetic disease with a proclivity for ventricular arrhythmias. We describe the multicenter experience with percutaneous catheter ablation of sustained monomorphic ventricular tachycardia (VT) in LMNA cardiomyopathy.
  
  
  
  Twenty-five consecutive LMNA mutation patients from 4 centers were included (mean age, 55±9 years; ejection fraction, 34±12%; VT storm in 36%). Complete atrioventricular block was present in 11 patients; 3 patients were on mechanical circulatory support for severe heart failure. A median of 3 VTs were inducible per patient; in 82%, mapping was consistent with origin from scar in the basal left ventricle, particularly the septum, but also basal inferior wall and subaortic mitral continuity. After multiple procedures (median 2/patient; transcoronary alcohol in 6 and surgical cryoablation in 2 patients), acute success (noninducibility of any VT) was achieved in only 25% of patients. Partial success (inducibility of a nonclinical VT only: 50%) and failure (persistent inducibility of clinical VT: 12.5%) was attributed to intramural septal substrate in 13 of 18 patients (72%). Complications occurred in 25% of patients. After a median follow-up of 7 months after the last procedure, 91% experienced ≥1 VT recurrence, 44% received or were awaiting mechanical circulatory support or transplant for end-stage heart failure, and 26% died.
  
  
  
  Catheter ablation of VT associated with LMNA cardiomyopathy is associated with poor outcomes including high rate of arrhythmia recurrence, progression to end-stage heart failure, and high mortality. Basal septal scar and intramural VT origin makes VT ablation challenging in this population.
authors: From the Cardiovascular Division, Brigham and Women's Hospital, Boston, MA (S.K., S.H.B., B.A.K., R.M.J., G.F.M., N.K.L., W.G.S., U.B.T.); Department of Cardiology, Leiden University Medical Centre, The Netherlands (A.F.A.A., K.Z.); Hôpital Cardiologique du Haut-Lévêque (CHU), Bordeaux-Pessac & L'Institut de RYthmologie et Modélisation Cardiaque (LIRYC), Institut Hospitalo-Universitaire (IHU), Bordeaux, France (J.-M.S., F.S.); Centre Hospitalier Universitaire de Nancy (J.-M.S.); Toulouse University Hospital, Rangueil, Toulouse (P.M., A.R.); Département de Cardiologie, Hôpital Pitié-Salpêtrière, AP-HP (J.-M.S., F.S., E.G., X.W.); Cardio-myogenetic, Department of Biochimie and INSERM U582, University Hospital Pitié-Salpêtrière, AP-HP (P.R.); Centre de Référence Maladies Cardiaques Héréditaires, ICAN, Hôpital Pitié-Salpêtrière, Paris (P.C.); and Université de Versailles-Saint Quentin, Hôpital Ambroise Paré, AP-HP, Boulogne-Billancourt, France (P.C.).
authors: Saurabh
authors: S
authors: Kumar
authors: From the Cardiovascular Division, Brigham and Women's Hospital, Boston, MA (S.K., S.H.B., B.A.K., R.M.J., G.F.M., N.K.L., W.G.S., U.B.T.); Department of Cardiology, Leiden University Medical Centre, The Netherlands (A.F.A.A., K.Z.); Hôpital Cardiologique du Haut-Lévêque (CHU), Bordeaux-Pessac & L'Institut de RYthmologie et Modélisation Cardiaque (LIRYC), Institut Hospitalo-Universitaire (IHU), Bordeaux, France (J.-M.S., F.S.); Centre Hospitalier Universitaire de Nancy (J.-M.S.); Toulouse University Hospital, Rangueil, Toulouse (P.M., A.R.); Département de Cardiologie, Hôpital Pitié-Salpêtrière, AP-HP (J.-M.S., F.S., E.G., X.W.); Cardio-myogenetic, Department of Biochimie and INSERM U582, University Hospital Pitié-Salpêtrière, AP-HP (P.R.); Centre de Référence Maladies Cardiaques Héréditaires, ICAN, Hôpital Pitié-Salpêtrière, Paris (P.C.); and Université de Versailles-Saint Quentin, Hôpital Ambroise Paré, AP-HP, Boulogne-Billancourt, France (P.C.).
authors: Alexander F A
authors: AF
authors: Androulakis
authors: From the Cardiovascular Division, Brigham and Women's Hospital, Boston, MA (S.K., S.H.B., B.A.K., R.M.J., G.F.M., N.K.L., W.G.S., U.B.T.); Department of Cardiology, Leiden University Medical Centre, The Netherlands (A.F.A.A., K.Z.); Hôpital Cardiologique du Haut-Lévêque (CHU), Bordeaux-Pessac & L'Institut de RYthmologie et Modélisation Cardiaque (LIRYC), Institut Hospitalo-Universitaire (IHU), Bordeaux, France (J.-M.S., F.S.); Centre Hospitalier Universitaire de Nancy (J.-M.S.); Toulouse University Hospital, Rangueil, Toulouse (P.M., A.R.); Département de Cardiologie, Hôpital Pitié-Salpêtrière, AP-HP (J.-M.S., F.S., E.G., X.W.); Cardio-myogenetic, Department of Biochimie and INSERM U582, University Hospital Pitié-Salpêtrière, AP-HP (P.R.); Centre de Référence Maladies Cardiaques Héréditaires, ICAN, Hôpital Pitié-Salpêtrière, Paris (P.C.); and Université de Versailles-Saint Quentin, Hôpital Ambroise Paré, AP-HP, Boulogne-Billancourt, France (P.C.).
authors: Jean-Marc
authors: JM
authors: Sellal
authors: From the Cardiovascular Division, Brigham and Women's Hospital, Boston, MA (S.K., S.H.B., B.A.K., R.M.J., G.F.M., N.K.L., W.G.S., U.B.T.); Department of Cardiology, Leiden University Medical Centre, The Netherlands (A.F.A.A., K.Z.); Hôpital Cardiologique du Haut-Lévêque (CHU), Bordeaux-Pessac & L'Institut de RYthmologie et Modélisation Cardiaque (LIRYC), Institut Hospitalo-Universitaire (IHU), Bordeaux, France (J.-M.S., F.S.); Centre Hospitalier Universitaire de Nancy (J.-M.S.); Toulouse University Hospital, Rangueil, Toulouse (P.M., A.R.); Département de Cardiologie, Hôpital Pitié-Salpêtrière, AP-HP (J.-M.S., F.S., E.G., X.W.); Cardio-myogenetic, Department of Biochimie and INSERM U582, University Hospital Pitié-Salpêtrière, AP-HP (P.R.); Centre de Référence Maladies Cardiaques Héréditaires, ICAN, Hôpital Pitié-Salpêtrière, Paris (P.C.); and Université de Versailles-Saint Quentin, Hôpital Ambroise Paré, AP-HP, Boulogne-Billancourt, France (P.C.).
authors: Philippe
authors: P
authors: Maury
authors: From the Cardiovascular Division, Brigham and Women's Hospital, Boston, MA (S.K., S.H.B., B.A.K., R.M.J., G.F.M., N.K.L., W.G.S., U.B.T.); Department of Cardiology, Leiden University Medical Centre, The Netherlands (A.F.A.A., K.Z.); Hôpital Cardiologique du Haut-Lévêque (CHU), Bordeaux-Pessac & L'Institut de RYthmologie et Modélisation Cardiaque (LIRYC), Institut Hospitalo-Universitaire (IHU), Bordeaux, France (J.-M.S., F.S.); Centre Hospitalier Universitaire de Nancy (J.-M.S.); Toulouse University Hospital, Rangueil, Toulouse (P.M., A.R.); Département de Cardiologie, Hôpital Pitié-Salpêtrière, AP-HP (J.-M.S., F.S., E.G., X.W.); Cardio-myogenetic, Department of Biochimie and INSERM U582, University Hospital Pitié-Salpêtrière, AP-HP (P.R.); Centre de Référence Maladies Cardiaques Héréditaires, ICAN, Hôpital Pitié-Salpêtrière, Paris (P.C.); and Université de Versailles-Saint Quentin, Hôpital Ambroise Paré, AP-HP, Boulogne-Billancourt, France (P.C.).
authors: Estelle
authors: E
authors: Gandjbakhch
authors: From the Cardiovascular Division, Brigham and Women's Hospital, Boston, MA (S.K., S.H.B., B.A.K., R.M.J., G.F.M., N.K.L., W.G.S., U.B.T.); Department of Cardiology, Leiden University Medical Centre, The Netherlands (A.F.A.A., K.Z.); Hôpital Cardiologique du Haut-Lévêque (CHU), Bordeaux-Pessac & L'Institut de RYthmologie et Modélisation Cardiaque (LIRYC), Institut Hospitalo-Universitaire (IHU), Bordeaux, France (J.-M.S., F.S.); Centre Hospitalier Universitaire de Nancy (J.-M.S.); Toulouse University Hospital, Rangueil, Toulouse (P.M., A.R.); Département de Cardiologie, Hôpital Pitié-Salpêtrière, AP-HP (J.-M.S., F.S., E.G., X.W.); Cardio-myogenetic, Department of Biochimie and INSERM U582, University Hospital Pitié-Salpêtrière, AP-HP (P.R.); Centre de Référence Maladies Cardiaques Héréditaires, ICAN, Hôpital Pitié-Salpêtrière, Paris (P.C.); and Université de Versailles-Saint Quentin, Hôpital Ambroise Paré, AP-HP, Boulogne-Billancourt, France (P.C.).
authors: Xavier
authors: X
authors: Waintraub
authors: From the Cardiovascular Division, Brigham and Women's Hospital, Boston, MA (S.K., S.H.B., B.A.K., R.M.J., G.F.M., N.K.L., W.G.S., U.B.T.); Department of Cardiology, Leiden University Medical Centre, The Netherlands (A.F.A.A., K.Z.); Hôpital Cardiologique du Haut-Lévêque (CHU), Bordeaux-Pessac & L'Institut de RYthmologie et Modélisation Cardiaque (LIRYC), Institut Hospitalo-Universitaire (IHU), Bordeaux, France (J.-M.S., F.S.); Centre Hospitalier Universitaire de Nancy (J.-M.S.); Toulouse University Hospital, Rangueil, Toulouse (P.M., A.R.); Département de Cardiologie, Hôpital Pitié-Salpêtrière, AP-HP (J.-M.S., F.S., E.G., X.W.); Cardio-myogenetic, Department of Biochimie and INSERM U582, University Hospital Pitié-Salpêtrière, AP-HP (P.R.); Centre de Référence Maladies Cardiaques Héréditaires, ICAN, Hôpital Pitié-Salpêtrière, Paris (P.C.); and Université de Versailles-Saint Quentin, Hôpital Ambroise Paré, AP-HP, Boulogne-Billancourt, France (P.C.).
authors: Anne
authors: A
authors: Rollin
authors: From the Cardiovascular Division, Brigham and Women's Hospital, Boston, MA (S.K., S.H.B., B.A.K., R.M.J., G.F.M., N.K.L., W.G.S., U.B.T.); Department of Cardiology, Leiden University Medical Centre, The Netherlands (A.F.A.A., K.Z.); Hôpital Cardiologique du Haut-Lévêque (CHU), Bordeaux-Pessac & L'Institut de RYthmologie et Modélisation Cardiaque (LIRYC), Institut Hospitalo-Universitaire (IHU), Bordeaux, France (J.-M.S., F.S.); Centre Hospitalier Universitaire de Nancy (J.-M.S.); Toulouse University Hospital, Rangueil, Toulouse (P.M., A.R.); Département de Cardiologie, Hôpital Pitié-Salpêtrière, AP-HP (J.-M.S., F.S., E.G., X.W.); Cardio-myogenetic, Department of Biochimie and INSERM U582, University Hospital Pitié-Salpêtrière, AP-HP (P.R.); Centre de Référence Maladies Cardiaques Héréditaires, ICAN, Hôpital Pitié-Salpêtrière, Paris (P.C.); and Université de Versailles-Saint Quentin, Hôpital Ambroise Paré, AP-HP, Boulogne-Billancourt, France (P.C.).
authors: Pascale
authors: P
authors: Richard
authors: From the Cardiovascular Division, Brigham and Women's Hospital, Boston, MA (S.K., S.H.B., B.A.K., R.M.J., G.F.M., N.K.L., W.G.S., U.B.T.); Department of Cardiology, Leiden University Medical Centre, The Netherlands (A.F.A.A., K.Z.); Hôpital Cardiologique du Haut-Lévêque (CHU), Bordeaux-Pessac & L'Institut de RYthmologie et Modélisation Cardiaque (LIRYC), Institut Hospitalo-Universitaire (IHU), Bordeaux, France (J.-M.S., F.S.); Centre Hospitalier Universitaire de Nancy (J.-M.S.); Toulouse University Hospital, Rangueil, Toulouse (P.M., A.R.); Département de Cardiologie, Hôpital Pitié-Salpêtrière, AP-HP (J.-M.S., F.S., E.G., X.W.); Cardio-myogenetic, Department of Biochimie and INSERM U582, University Hospital Pitié-Salpêtrière, AP-HP (P.R.); Centre de Référence Maladies Cardiaques Héréditaires, ICAN, Hôpital Pitié-Salpêtrière, Paris (P.C.); and Université de Versailles-Saint Quentin, Hôpital Ambroise Paré, AP-HP, Boulogne-Billancourt, France (P.C.).
authors: Philippe
authors: P
authors: Charron
authors: From the Cardiovascular Division, Brigham and Women's Hospital, Boston, MA (S.K., S.H.B., B.A.K., R.M.J., G.F.M., N.K.L., W.G.S., U.B.T.); Department of Cardiology, Leiden University Medical Centre, The Netherlands (A.F.A.A., K.Z.); Hôpital Cardiologique du Haut-Lévêque (CHU), Bordeaux-Pessac & L'Institut de RYthmologie et Modélisation Cardiaque (LIRYC), Institut Hospitalo-Universitaire (IHU), Bordeaux, France (J.-M.S., F.S.); Centre Hospitalier Universitaire de Nancy (J.-M.S.); Toulouse University Hospital, Rangueil, Toulouse (P.M., A.R.); Département de Cardiologie, Hôpital Pitié-Salpêtrière, AP-HP (J.-M.S., F.S., E.G., X.W.); Cardio-myogenetic, Department of Biochimie and INSERM U582, University Hospital Pitié-Salpêtrière, AP-HP (P.R.); Centre de Référence Maladies Cardiaques Héréditaires, ICAN, Hôpital Pitié-Salpêtrière, Paris (P.C.); and Université de Versailles-Saint Quentin, Hôpital Ambroise Paré, AP-HP, Boulogne-Billancourt, France (P.C.).
authors: Samuel H
authors: SH
authors: Baldinger
authors: From the Cardiovascular Division, Brigham and Women's Hospital, Boston, MA (S.K., S.H.B., B.A.K., R.M.J., G.F.M., N.K.L., W.G.S., U.B.T.); Department of Cardiology, Leiden University Medical Centre, The Netherlands (A.F.A.A., K.Z.); Hôpital Cardiologique du Haut-Lévêque (CHU), Bordeaux-Pessac & L'Institut de RYthmologie et Modélisation Cardiaque (LIRYC), Institut Hospitalo-Universitaire (IHU), Bordeaux, France (J.-M.S., F.S.); Centre Hospitalier Universitaire de Nancy (J.-M.S.); Toulouse University Hospital, Rangueil, Toulouse (P.M., A.R.); Département de Cardiologie, Hôpital Pitié-Salpêtrière, AP-HP (J.-M.S., F.S., E.G., X.W.); Cardio-myogenetic, Department of Biochimie and INSERM U582, University Hospital Pitié-Salpêtrière, AP-HP (P.R.); Centre de Référence Maladies Cardiaques Héréditaires, ICAN, Hôpital Pitié-Salpêtrière, Paris (P.C.); and Université de Versailles-Saint Quentin, Hôpital Ambroise Paré, AP-HP, Boulogne-Billancourt, France (P.C.).
authors: Ciorsti J
authors: CJ
authors: Macintyre
authors: From the Cardiovascular Division, Brigham and Women's Hospital, Boston, MA (S.K., S.H.B., B.A.K., R.M.J., G.F.M., N.K.L., W.G.S., U.B.T.); Department of Cardiology, Leiden University Medical Centre, The Netherlands (A.F.A.A., K.Z.); Hôpital Cardiologique du Haut-Lévêque (CHU), Bordeaux-Pessac & L'Institut de RYthmologie et Modélisation Cardiaque (LIRYC), Institut Hospitalo-Universitaire (IHU), Bordeaux, France (J.-M.S., F.S.); Centre Hospitalier Universitaire de Nancy (J.-M.S.); Toulouse University Hospital, Rangueil, Toulouse (P.M., A.R.); Département de Cardiologie, Hôpital Pitié-Salpêtrière, AP-HP (J.-M.S., F.S., E.G., X.W.); Cardio-myogenetic, Department of Biochimie and INSERM U582, University Hospital Pitié-Salpêtrière, AP-HP (P.R.); Centre de Référence Maladies Cardiaques Héréditaires, ICAN, Hôpital Pitié-Salpêtrière, Paris (P.C.); and Université de Versailles-Saint Quentin, Hôpital Ambroise Paré, AP-HP, Boulogne-Billancourt, France (P.C.).
authors: Bruce A
authors: BA
authors: Koplan
authors: From the Cardiovascular Division, Brigham and Women's Hospital, Boston, MA (S.K., S.H.B., B.A.K., R.M.J., G.F.M., N.K.L., W.G.S., U.B.T.); Department of Cardiology, Leiden University Medical Centre, The Netherlands (A.F.A.A., K.Z.); Hôpital Cardiologique du Haut-Lévêque (CHU), Bordeaux-Pessac & L'Institut de RYthmologie et Modélisation Cardiaque (LIRYC), Institut Hospitalo-Universitaire (IHU), Bordeaux, France (J.-M.S., F.S.); Centre Hospitalier Universitaire de Nancy (J.-M.S.); Toulouse University Hospital, Rangueil, Toulouse (P.M., A.R.); Département de Cardiologie, Hôpital Pitié-Salpêtrière, AP-HP (J.-M.S., F.S., E.G., X.W.); Cardio-myogenetic, Department of Biochimie and INSERM U582, University Hospital Pitié-Salpêtrière, AP-HP (P.R.); Centre de Référence Maladies Cardiaques Héréditaires, ICAN, Hôpital Pitié-Salpêtrière, Paris (P.C.); and Université de Versailles-Saint Quentin, Hôpital Ambroise Paré, AP-HP, Boulogne-Billancourt, France (P.C.).
authors: Roy M
authors: RM
authors: John
authors: From the Cardiovascular Division, Brigham and Women's Hospital, Boston, MA (S.K., S.H.B., B.A.K., R.M.J., G.F.M., N.K.L., W.G.S., U.B.T.); Department of Cardiology, Leiden University Medical Centre, The Netherlands (A.F.A.A., K.Z.); Hôpital Cardiologique du Haut-Lévêque (CHU), Bordeaux-Pessac & L'Institut de RYthmologie et Modélisation Cardiaque (LIRYC), Institut Hospitalo-Universitaire (IHU), Bordeaux, France (J.-M.S., F.S.); Centre Hospitalier Universitaire de Nancy (J.-M.S.); Toulouse University Hospital, Rangueil, Toulouse (P.M., A.R.); Département de Cardiologie, Hôpital Pitié-Salpêtrière, AP-HP (J.-M.S., F.S., E.G., X.W.); Cardio-myogenetic, Department of Biochimie and INSERM U582, University Hospital Pitié-Salpêtrière, AP-HP (P.R.); Centre de Référence Maladies Cardiaques Héréditaires, ICAN, Hôpital Pitié-Salpêtrière, Paris (P.C.); and Université de Versailles-Saint Quentin, Hôpital Ambroise Paré, AP-HP, Boulogne-Billancourt, France (P.C.).
authors: Gregory F
authors: GF
authors: Michaud
authors: From the Cardiovascular Division, Brigham and Women's Hospital, Boston, MA (S.K., S.H.B., B.A.K., R.M.J., G.F.M., N.K.L., W.G.S., U.B.T.); Department of Cardiology, Leiden University Medical Centre, The Netherlands (A.F.A.A., K.Z.); Hôpital Cardiologique du Haut-Lévêque (CHU), Bordeaux-Pessac & L'Institut de RYthmologie et Modélisation Cardiaque (LIRYC), Institut Hospitalo-Universitaire (IHU), Bordeaux, France (J.-M.S., F.S.); Centre Hospitalier Universitaire de Nancy (J.-M.S.); Toulouse University Hospital, Rangueil, Toulouse (P.M., A.R.); Département de Cardiologie, Hôpital Pitié-Salpêtrière, AP-HP (J.-M.S., F.S., E.G., X.W.); Cardio-myogenetic, Department of Biochimie and INSERM U582, University Hospital Pitié-Salpêtrière, AP-HP (P.R.); Centre de Référence Maladies Cardiaques Héréditaires, ICAN, Hôpital Pitié-Salpêtrière, Paris (P.C.); and Université de Versailles-Saint Quentin, Hôpital Ambroise Paré, AP-HP, Boulogne-Billancourt, France (P.C.).
authors: Katja
authors: K
authors: Zeppenfeld
authors: From the Cardiovascular Division, Brigham and Women's Hospital, Boston, MA (S.K., S.H.B., B.A.K., R.M.J., G.F.M., N.K.L., W.G.S., U.B.T.); Department of Cardiology, Leiden University Medical Centre, The Netherlands (A.F.A.A., K.Z.); Hôpital Cardiologique du Haut-Lévêque (CHU), Bordeaux-Pessac & L'Institut de RYthmologie et Modélisation Cardiaque (LIRYC), Institut Hospitalo-Universitaire (IHU), Bordeaux, France (J.-M.S., F.S.); Centre Hospitalier Universitaire de Nancy (J.-M.S.); Toulouse University Hospital, Rangueil, Toulouse (P.M., A.R.); Département de Cardiologie, Hôpital Pitié-Salpêtrière, AP-HP (J.-M.S., F.S., E.G., X.W.); Cardio-myogenetic, Department of Biochimie and INSERM U582, University Hospital Pitié-Salpêtrière, AP-HP (P.R.); Centre de Référence Maladies Cardiaques Héréditaires, ICAN, Hôpital Pitié-Salpêtrière, Paris (P.C.); and Université de Versailles-Saint Quentin, Hôpital Ambroise Paré, AP-HP, Boulogne-Billancourt, France (P.C.).
authors: Frederic
authors: F
authors: Sacher
authors: From the Cardiovascular Division, Brigham and Women's Hospital, Boston, MA (S.K., S.H.B., B.A.K., R.M.J., G.F.M., N.K.L., W.G.S., U.B.T.); Department of Cardiology, Leiden University Medical Centre, The Netherlands (A.F.A.A., K.Z.); Hôpital Cardiologique du Haut-Lévêque (CHU), Bordeaux-Pessac & L'Institut de RYthmologie et Modélisation Cardiaque (LIRYC), Institut Hospitalo-Universitaire (IHU), Bordeaux, France (J.-M.S., F.S.); Centre Hospitalier Universitaire de Nancy (J.-M.S.); Toulouse University Hospital, Rangueil, Toulouse (P.M., A.R.); Département de Cardiologie, Hôpital Pitié-Salpêtrière, AP-HP (J.-M.S., F.S., E.G., X.W.); Cardio-myogenetic, Department of Biochimie and INSERM U582, University Hospital Pitié-Salpêtrière, AP-HP (P.R.); Centre de Référence Maladies Cardiaques Héréditaires, ICAN, Hôpital Pitié-Salpêtrière, Paris (P.C.); and Université de Versailles-Saint Quentin, Hôpital Ambroise Paré, AP-HP, Boulogne-Billancourt, France (P.C.).
authors: Neal K
authors: NK
authors: Lakdawala
authors: From the Cardiovascular Division, Brigham and Women's Hospital, Boston, MA (S.K., S.H.B., B.A.K., R.M.J., G.F.M., N.K.L., W.G.S., U.B.T.); Department of Cardiology, Leiden University Medical Centre, The Netherlands (A.F.A.A., K.Z.); Hôpital Cardiologique du Haut-Lévêque (CHU), Bordeaux-Pessac & L'Institut de RYthmologie et Modélisation Cardiaque (LIRYC), Institut Hospitalo-Universitaire (IHU), Bordeaux, France (J.-M.S., F.S.); Centre Hospitalier Universitaire de Nancy (J.-M.S.); Toulouse University Hospital, Rangueil, Toulouse (P.M., A.R.); Département de Cardiologie, Hôpital Pitié-Salpêtrière, AP-HP (J.-M.S., F.S., E.G., X.W.); Cardio-myogenetic, Department of Biochimie and INSERM U582, University Hospital Pitié-Salpêtrière, AP-HP (P.R.); Centre de Référence Maladies Cardiaques Héréditaires, ICAN, Hôpital Pitié-Salpêtrière, Paris (P.C.); and Université de Versailles-Saint Quentin, Hôpital Ambroise Paré, AP-HP, Boulogne-Billancourt, France (P.C.).
authors: William G
authors: WG
authors: Stevenson
authors: From the Cardiovascular Division, Brigham and Women's Hospital, Boston, MA (S.K., S.H.B., B.A.K., R.M.J., G.F.M., N.K.L., W.G.S., U.B.T.); Department of Cardiology, Leiden University Medical Centre, The Netherlands (A.F.A.A., K.Z.); Hôpital Cardiologique du Haut-Lévêque (CHU), Bordeaux-Pessac & L'Institut de RYthmologie et Modélisation Cardiaque (LIRYC), Institut Hospitalo-Universitaire (IHU), Bordeaux, France (J.-M.S., F.S.); Centre Hospitalier Universitaire de Nancy (J.-M.S.); Toulouse University Hospital, Rangueil, Toulouse (P.M., A.R.); Département de Cardiologie, Hôpital Pitié-Salpêtrière, AP-HP (J.-M.S., F.S., E.G., X.W.); Cardio-myogenetic, Department of Biochimie and INSERM U582, University Hospital Pitié-Salpêtrière, AP-HP (P.R.); Centre de Référence Maladies Cardiaques Héréditaires, ICAN, Hôpital Pitié-Salpêtrière, Paris (P.C.); and Université de Versailles-Saint Quentin, Hôpital Ambroise Paré, AP-HP, Boulogne-Billancourt, France (P.C.). utedrow@partners.org westpennant@gmail.com.
authors: Usha B
authors: UB
authors: Tedrow
mesh_terms: D000328:Adult; D000368:Aged; D009202:Cardiomyopathies / Q000235:genetics* / Q000601:surgery*; D017115:Catheter Ablation / Q000379:methods*; D056149:Epicardial Mapping; D005260:Female; D006801:Humans; D034904:Lamin Type A; D008297:Male; D008875:Middle Aged; D009154:Mutation; D010641:Phenotype; D012008:Recurrence; D012189:Retrospective Studies; D013318:Stroke Volume; D017180:Tachycardia, Ventricular / Q000235:genetics* / Q000601:surgery*; D016896:Treatment Outcome
chemical_list: D034904:Lamin Type A
keywords: catheter ablation; heart failure; ventricular fibrillation; ventricular tachycardia