title: Impact of analysis interval size on the quality of optical frequency domain imaging assessments of stent implantation for lesions of the superficial femoral artery.
abstract: OBJECTIVE
  This study aimed to investigate the influence of analysis interval size on optical frequency domain imaging (OFDI) assessment of stent therapy for lesions of the superficial femoral artery (SFA).
  
  
  BACKGROUND
  No consensus or validating data are available with respect to the methodology of intravascular imaging analysis for the peripheral arteries.
  
  
  METHODS
  OFDI was performed for 30 SFA lesions, during endovascular therapy and at the 6-month follow-up. Initially, lumen and stent borders were traced at 1-mm axial intervals. Volumes were calculated using a PC-based software, and the volume index (VI) was defined as the volume divided by the stent length. Two additional OFDI analyses were performed using 2-mm and 5-mm intervals, thereby reducing the number of cross-sectional image frames analyzed.
  
  
  RESULTS
  The mean stent length was 89.7 ± 35.2 mm. The mean difference in baseline minimum lumen area (MLA) was 0.4 mm2between MLA values from the 1-mm and 2-mm interval analyses, and 2.2 mm2between MLA values from the 1-mm and 5-mm interval analyses. In volumetric analysis, there were excellent correlations and good agreements for stent, lumen, and neointimal VI measurements obtained on the basis of different analysis intervals.
  
  
  CONCLUSIONS
  Using large intervals in OFDI analyses of SFA lesions resulted in few differences in measurement variability of volumetric parameters. However, planar analysis for MLA assessment can be susceptible to high variability when large intervals are applied. © 2016 Wiley Periodicals, Inc.
authors: Division of Cardiovascular Medicine Stanford University School of Medicine, Stanford, California.|Division of Cardiovascular Medicine and Coronary Heart Disease Hyogo College of Medicine, Nishinomiya, Japan.
authors: Kojiro
authors: K
authors: Miki
authors: Division of Cardiovascular Medicine and Coronary Heart Disease Hyogo College of Medicine, Nishinomiya, Japan.
authors: Kenichi
authors: K
authors: Fujii
authors: Division of Cardiovascular Medicine, Morinomiya Hospital, Cardiovascular Center, Osaka, Japan.
authors: Daizo
authors: D
authors: Kawasaki
authors: Division of Cardiovascular Medicine and Coronary Heart Disease Hyogo College of Medicine, Nishinomiya, Japan.
authors: Masahiko
authors: M
authors: Shibuya
authors: Division of Cardiovascular Medicine, Morinomiya Hospital, Cardiovascular Center, Osaka, Japan.
authors: Masashi
authors: M
authors: Fukunaga
authors: Division of Cardiovascular Medicine and Coronary Heart Disease Hyogo College of Medicine, Nishinomiya, Japan.
authors: Takahiro
authors: T
authors: Imanaka
authors: Division of Cardiovascular Medicine and Coronary Heart Disease Hyogo College of Medicine, Nishinomiya, Japan.
authors: Hiroto
authors: H
authors: Tamaru
authors: Division of Cardiovascular Medicine and Coronary Heart Disease Hyogo College of Medicine, Nishinomiya, Japan.
authors: Akinori
authors: A
authors: Sumiyoshi
authors: Division of Cardiovascular Medicine and Coronary Heart Disease Hyogo College of Medicine, Nishinomiya, Japan.
authors: Machiko
authors: M
authors: Nishimura
authors: Division of Cardiovascular Medicine and Coronary Heart Disease Hyogo College of Medicine, Nishinomiya, Japan.
authors: Tetsuo
authors: T
authors: Horimatsu
authors: Division of Cardiovascular Medicine and Coronary Heart Disease Hyogo College of Medicine, Nishinomiya, Japan.
authors: Ten
authors: T
authors: Saita
authors: Division of Cardiovascular Medicine Stanford University School of Medicine, Stanford, California.
authors: Yuhei
authors: Y
authors: Kobayashi
authors: Division of Cardiovascular Medicine Stanford University School of Medicine, Stanford, California.
authors: Yasuhiro
authors: Y
authors: Honda
authors: Division of Cardiovascular Medicine Stanford University School of Medicine, Stanford, California.
authors: Peter J
authors: PJ
authors: Fitzgerald
authors: Division of Cardiovascular Medicine and Coronary Heart Disease Hyogo College of Medicine, Nishinomiya, Japan.
authors: Tohru
authors: T
authors: Masuyama
authors: Division of Cardiovascular Medicine and Coronary Heart Disease Hyogo College of Medicine, Nishinomiya, Japan.
authors: Masaharu
authors: M
authors: Ishihara
mesh_terms: D000368:Aged; D000792:Angiography; D003430:Cross-Sectional Studies; D057510:Endovascular Procedures / Q000592:standards*; D005260:Female; D005263:Femoral Artery / Q000000981:diagnostic imaging / Q000601:surgery*; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D058729:Peripheral Arterial Disease / Q000175:diagnosis* / Q000601:surgery; D011446:Prospective Studies; D015203:Reproducibility of Results; D015607:Stents; D013997:Time Factors; D041623:Tomography, Optical Coherence / Q000379:methods
keywords: endovascular therapy; optical coherence tomography; peripheral artery disease