title: The role of microRNAs in resistance to targeted treatments of non-small cell lung cancer.
abstract: Non-small cell lung cancer (NSCLC), accounting for the most of lung cancers, is usually diagnosed in advanced stage. Targeted treatments boost advanced NSCLC patients with certain mutations, but early drug resistance blocks the advantages of target medicine. MicroRNAs (miRNAs) are regarded as a cluster of small noncoding and posttranscriptionally negative regulating RNAs. We want to explore the role of miRNAs in resistance to targeted treatments of NSCLC to improve the prognosis.
  
  
  
  We reviewed recent studies about miRNAs and targeted treatment resistance in NSCLC and classified resistance into two types: EGFR-TKIs resistance and ALK-TKIs resistance.
  
  
  
  Recent studies indicate that miRNAs involve in drug resistance possession in positive and negative manners. Inhibiting expression of certain miRNAs that promote drug resistance and increasing expression of miRNAs that reverse drug resistance may illuminate novel prospect of adjuvant targeted treatments in NSCLC.
authors: Department of Pathology, The Second Xiangya Hospital of Central South University, Changsha, 410011, Hunan, China.
authors: Hongjing
authors: H
authors: Zang
authors: Department of Pathology, The Second Xiangya Hospital of Central South University, Changsha, 410011, Hunan, China.
authors: Weiyuan
authors: W
authors: Wang
authors: Department of Pathology, The Second Xiangya Hospital of Central South University, Changsha, 410011, Hunan, China. fansongqing2003@hotmail.com.
authors: Songqing
authors: S
authors: Fan
mesh_terms: D000077548:Anaplastic Lymphoma Kinase; D002289:Carcinoma, Non-Small-Cell Lung / Q000188:drug therapy*; D019008:Drug Resistance, Neoplasm; D066246:ErbB Receptors / Q000037:antagonists & inhibitors; D000077156:Gefitinib; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy*; D035683:MicroRNAs / Q000502:physiology*; D058990:Molecular Targeted Therapy; D011799:Quinazolines / Q000627:therapeutic use; D020794:Receptor Protein-Tyrosine Kinases / Q000037:antagonists & inhibitors
chemical_list: D035683:MicroRNAs; D011799:Quinazolines; C000626173:ALK protein, human; D000077548:Anaplastic Lymphoma Kinase; D066246:ErbB Receptors; D020794:Receptor Protein-Tyrosine Kinases; D000077156:Gefitinib
keywords: Drug resistance; EGFR; MicroRNAs; NSCLC; Targeted treatment