title: Optical discrimination of benign and malignant oral tissue using Z-scan technique.
abstract: A new optical method to discriminate benign and malignant oral tissue is reported. Twenty four tissue biopsy of patients tumor have been prepared in standard method without coloring process. The CW He-Ne laser beam interrogated the samples in optical setup. Linear absorption of tissues in laser wavelength measured and nonlinear behavior of tissue biopsies has been investigated by Z-scan setup. We used some simple optical instruments to focus on microsize region of biolayer to investigate less number of cells and to take repeatable test. Results show that the malignant samples have more attenuation than benign samples. Furthermore nonlinear refractive index (n2) of malignant biolayers has positive sign and n2of benign biopsies has negative sign with the 10-8(cm2/W) order of magnitude. So this optical method may be used to discriminate malignant from benign tissues.
authors: Photonics Lab., Department of physics, University of Kharazmi, Mofatteh Ave., Tehran,Iran.
authors: Mohajer
authors: M
authors: Salman
authors: Photonics Lab., Department of physics, University of Kharazmi, Mofatteh Ave., Tehran,Iran. Electronic address: hamraheshoma2012@gmail.com.
authors: Majles Ara Mohammad
authors: MA
authors: Hossein
authors: ENT and Head & Neck Research center and Department, Hazrat Rasoul Akram Hospital, Iran University of Medical Sciences (IUMS), Tehran, Iran.
authors: Kamrava Seyed
authors: KS
authors: Kamran
authors: ENT and Head & Neck Research center and Department, Hazrat Rasoul Akram Hospital, Iran University of Medical Sciences (IUMS), Tehran, Iran.
authors: Maleki
authors: M
authors: Shayan
mesh_terms: D003936:Diagnosis, Computer-Assisted / Q000379:methods*; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008297:Male; D018613:Microscopy, Confocal / Q000379:methods*; D009062:Mouth Neoplasms / Q000145:classification / Q000175:diagnosis* / Q000473:pathology*; D012031:Refractometry / Q000379:methods*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity
keywords: Malignant and benign oral tissue; Nonlinear refractive index; Z-scan method