title: Pregnancy outcomes in cystic fibrosis: a 10-year experience from a UK centre.
abstract: BACKGROUND
  Cystic fibrosis manifests as a multisystem disease, despite this female fertility is relatively preserved with levels approaching that of the non-cystic fibrosis population. We reviewed pregnancies in cystic fibrosis patients over a 10-year period from a UK adult cystic fibrosis centre by considering maternal and fetal outcomes.
  
  
  METHODS
  We conducted a retrospective case-note review of pregnancies during 2003-2013 using respiratory and obstetric records.
  
  
  RESULTS
  We observed moderate falls in lung function immediately after delivery, which persisted at 12 months postpartum. We found that a decline in lung function at delivery was a marker for further decline in function during the subsequent postpartum period. We found baseline lung function was predictive of gestational age at delivery. We observed a high incidence of haemoptysis.
  
  
  CONCLUSIONS
  Consistent with current guidance we found pregnancy is feasible and well tolerated in the majority of patients with cystic fibrosis. There was a high incidence of haemoptysis, which warrants further study.
authors: St John's College, University of Oxford, Oxford, UK.
authors: M
authors: M
authors: Renton
authors: Oxford University Hospitals NHS Trust, Oxford, UK.
authors: L
authors: L
authors: Priestley
authors: Oxford University Hospitals NHS Trust, Oxford, UK.
authors: L
authors: L
authors: Bennett
authors: Oxford University Hospitals NHS Trust, Oxford, UK.
authors: L
authors: L
authors: Mackillop
authors: Oxford University Hospitals NHS Trust, Oxford, UK.
authors: S J
authors: SJ
authors: Chapman
keywords: High-risk pregnancy; complications; maternal-fetal medicine; perinatal medicine; thoracic medicine