title: Clinical outcome in patients with peripherally-sited atypical lipomatous tumours and dedifferentiated liposarcoma.
abstract: The reported incidence of local recurrence of peripheral atypical lipomatous tumours is highly variable and is likely to reflect the different inclusion criteria of cases, and the design of previous studies. We aimed to study the incidence of local recurrence of 90 cases of atypical lipomatous tumours and an additional 18 cases of de novo dedifferentiated liposarcoma. All tumours were diagnosed on the basis of MDM2 amplification: all patients had their first treatment in the same specialist sarcoma unit and were followed for a minimum of 60 months. The tumours were diagnosed between 1997 and 2009 and followed until the end of 2014. Seventy cases (78%) of atypical lipomatous tumours were located in the thigh (mean size 195 mm on presentation). Eight atypical lipomatous tumours (8.9%) recurred locally, of which 50% recurred after 60 months. The only two tumours with intralesional excisions recurred. Seven of the eight recurrent tumours were detected by the patient by self-examination. One case recurred a second time as a dedifferentiated liposarcoma. Seventeen per cent of the de novo dedifferentiated liposarcomas recurred within 60 months of presentation. Extending the study period revealed that atypical lipomatous tumour could recur up to 40 years after the first surgery. Furthermore, of 26 tumours that recurred in the extended study, 27% recurred more than once, and three of the seven that recurred more than once transformed into a dedifferentiated liposarcoma. We recommend that, following post-operative wound care, patients with atypical lipomatous tumour are referred back to their general practitioner for follow up, but that in the event of a suspected recurrence they have rapid access back to the specialist unit using a 'supported discharge' scheme. In the event of an intralesional excision and if a lesion recurs, patients are followed in a specialist unit at regular intervals: whether MRI scanning is a valuable means of monitoring such patients is unclear and requires an evidence base.
authors: Department of HistopathologyRoyal National Orthopaedic Hospital NHS TrustStanmoreMiddlesexUK; Department(s) of HistopathologyRadiologySurgery and OncologyLondon Sarcoma ServiceRoyal National Orthopaedic Hospital NHS Trust and University College London Hospitals Foundation TrustLondonUK.
authors: Sangeetha N
authors: SN
authors: Kalimuthu
authors: Department of HistopathologyRoyal National Orthopaedic Hospital NHS TrustStanmoreMiddlesexUK; Department(s) of HistopathologyRadiologySurgery and OncologyLondon Sarcoma ServiceRoyal National Orthopaedic Hospital NHS Trust and University College London Hospitals Foundation TrustLondonUK.
authors: Charles
authors: C
authors: Tilley
authors: Department of HistopathologyRoyal National Orthopaedic Hospital NHS TrustStanmoreMiddlesexUK; Department(s) of HistopathologyRadiologySurgery and OncologyLondon Sarcoma ServiceRoyal National Orthopaedic Hospital NHS Trust and University College London Hospitals Foundation TrustLondonUK.
authors: Georgina
authors: G
authors: Forbes
authors: Department of HistopathologyRoyal National Orthopaedic Hospital NHS TrustStanmoreMiddlesexUK; Department(s) of HistopathologyRadiologySurgery and OncologyLondon Sarcoma ServiceRoyal National Orthopaedic Hospital NHS Trust and University College London Hospitals Foundation TrustLondonUK.
authors: Hongtao
authors: H
authors: Ye
authors: Department of HistopathologyRoyal National Orthopaedic Hospital NHS TrustStanmoreMiddlesexUK; Department(s) of HistopathologyRadiologySurgery and OncologyLondon Sarcoma ServiceRoyal National Orthopaedic Hospital NHS Trust and University College London Hospitals Foundation TrustLondonUK.
authors: Katie
authors: K
authors: Lehovsky
authors: Department of HistopathologyRoyal National Orthopaedic Hospital NHS TrustStanmoreMiddlesexUK; Department(s) of HistopathologyRadiologySurgery and OncologyLondon Sarcoma ServiceRoyal National Orthopaedic Hospital NHS Trust and University College London Hospitals Foundation TrustLondonUK; Research Department of PathologyUCL Cancer InstituteHuntley StreetLondonUK.
authors: Nischalan
authors: N
authors: Pillay
authors: Department(s) of HistopathologyRadiologySurgery and OncologyLondon Sarcoma ServiceRoyal National Orthopaedic Hospital NHS Trust and University College London Hospitals Foundation TrustLondonUK; Department of OncologyUniversity College London Hospitals Foundation TrustLondonUK.
authors: Beatrice M
authors: BM
authors: Seddon
authors: Department(s) of HistopathologyRadiologySurgery and OncologyLondon Sarcoma ServiceRoyal National Orthopaedic Hospital NHS Trust and University College London Hospitals Foundation TrustLondonUK; Department of RadiologyRoyal National Orthopaedic Hospital NHS TrustStanmoreMiddlesexUK; Department of RadiologyInstitute of Orthopaedics and Musculoskeletal Science, UCLStanmoreUK.
authors: Paul
authors: P
authors: O'Donnell
authors: Department(s) of HistopathologyRadiologySurgery and OncologyLondon Sarcoma ServiceRoyal National Orthopaedic Hospital NHS Trust and University College London Hospitals Foundation TrustLondonUK; Department of SurgeryThe Bone Tumour Unit, Royal National Orthopaedic Hospital NHS TrustStanmoreMiddlesexUK.
authors: Robin
authors: R
authors: Pollock
authors: Department of HistopathologyRoyal National Orthopaedic Hospital NHS TrustStanmoreMiddlesexUK; Department(s) of HistopathologyRadiologySurgery and OncologyLondon Sarcoma ServiceRoyal National Orthopaedic Hospital NHS Trust and University College London Hospitals Foundation TrustLondonUK.
authors: Roberto
authors: R
authors: Tirabosco
authors: Department of HistopathologyRoyal National Orthopaedic Hospital NHS TrustStanmoreMiddlesexUK; Department(s) of HistopathologyRadiologySurgery and OncologyLondon Sarcoma ServiceRoyal National Orthopaedic Hospital NHS Trust and University College London Hospitals Foundation TrustLondonUK; Research Department of PathologyUCL Cancer InstituteHuntley StreetLondonUK.
authors: M Fernanda
authors: MF
authors: Amary
authors: Department of HistopathologyRoyal National Orthopaedic Hospital NHS TrustStanmoreMiddlesexUK; Department(s) of HistopathologyRadiologySurgery and OncologyLondon Sarcoma ServiceRoyal National Orthopaedic Hospital NHS Trust and University College London Hospitals Foundation TrustLondonUK; Research Department of PathologyUCL Cancer InstituteHuntley StreetLondonUK.
authors: Adrienne M
authors: AM
authors: Flanagan
keywords: MDM2; atypical lipomatous tumour; dedifferentiated liposarcoma; fluorescence in situ hybridisation; well differentiated liposarcoma