title: Thrombotic thrombocytopenic purpura: The role of ADAMTS13.
abstract: Thrombotic thrombocytopenic purpura (TTP) is an uncommon, life-threatening disease requiring prompt diagnosis and initiation of therapeutic plasma exchange to improve patient survival. However, diagnosis is often difficult because of atypical presentations and signs and symptoms that resemble other conditions. Measurements of ADAMTS13 activity, ADAMTS13 inhibitor, and ADAMTS13 autoantibody are useful for diagnosing TTP, guiding therapy, and predicting relapse.
authors: Medical Director of Hemostasis and Thrombosis, Hematopathologist, Department of Laboratory Medicine, Cleveland Clinic, Cleveland, OH, USA. E-mail: rogersj5@ccf.org.|Assistant Professor, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH, USA.
authors: Heesun J
authors: HJ
authors: Rogers
authors: Department of Laboratory Medicine, Cleveland Clinic, Cleveland, OH, USA.
authors: Charles
authors: C
authors: Allen
authors: Department of Hematologic Oncology and Blood Disorders, Cleveland Clinic; Cleveland, OH, USA.|Associate Professor, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH, USA.
authors: Alan E
authors: AE
authors: Lichtin
mesh_terms: D000071120:ADAMTS13 Protein / Q000037:antagonists & inhibitors / Q000097:blood* / Q000276:immunology; D001323:Autoantibodies / Q000097:blood; D006801:Humans; D010951:Plasma Exchange; D011697:Purpura, Thrombotic Thrombocytopenic / Q000097:blood* / Q000175:diagnosis / Q000276:immunology / Q000628:therapy; D012008:Recurrence
chemical_list: D001323:Autoantibodies; D000071120:ADAMTS13 Protein; C099604:ADAMTS13 protein, human