title: Effect of antidepressants on spatial memory deficit induced by dizocilpine.
abstract: Cognitive deficits are a core symptom of schizophrenia. It is controversial whether antidepressants could improve cognitive symptoms in schizophrenia patients. The present study was designed to identify the therapeutic effect of antidepressants on cognitive deficits in schizophrenia. In the present study, adolescent rats were repeatedly exposed to dizocilpine, which can induce cognitive deficits associated with schizophrenia. Then these rats were treated by six antidepressants (fluvoxamine, sertraline, paroxetine, escitalopram, venlafaxine, mirtazapine) or vehicle. The rats in the control group were exposed to vehicle during the study. Lastly, all rats' spatial memory (a major part of cognition) was assessed using the Morris water maze (MWM) test, and the density of hippocampal parvalbumin (PV) interneurons was evaluated to explore possible mechanisms underlying spatial memory change in schizophrenia. The results of the present study supported the hypothesis of a therapeutic effect of fluvoxamine and escitalopram on spatial memory deficit induced by dizocilpine. Additionally, the data of the present study suggested that fluvoxamine and escitalopram remitted hippocampal PV interneuron reduction induced by dizocilpine. The neuroprotective effect of fluvoxamine and escitalopram may partly explain the therapeutic effect of antidepressants on spatial memory deficit in schizophrenia patients.
authors: Department of Neurology, Affiliated Hospital of Hangzhou Normal University, Hangzhou 310015, PR China.
authors: Chenjuan
authors: C
authors: Tao
authors: Department of Occupational Medicine, Hangzhou Red Cross Hospital, Hangzhou 310015, PR China.
authors: Weiwei
authors: W
authors: Yan
authors: Department of Otolaryngology, Affiliated Hospital of Hangzhou Normal University, Hangzhou 310015, PR China. Electronic address: Liyuantg2015@163.com.
authors: Yuan
authors: Y
authors: Li
authors: Department of Neurology, Affiliated Hospital of Hangzhou Normal University, Hangzhou 310015, PR China.
authors: Xiaodong
authors: X
authors: Lu
mesh_terms: D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology*; D002452:Cell Count; D015283:Citalopram / Q000494:pharmacology; D003071:Cognition / Q000187:drug effects*; D060825:Cognitive Dysfunction / Q000523:psychology; D016291:Dizocilpine Maleate / Q000494:pharmacology*; D018691:Excitatory Amino Acid Antagonists / Q000494:pharmacology*; D016666:Fluvoxamine / Q000494:pharmacology; D006624:Hippocampus / Q000166:cytology / Q000187:drug effects*; D007395:Interneurons / Q000187:drug effects*; D008297:Male; D018782:Maze Learning / Q000187:drug effects; D008569:Memory Disorders / Q000139:chemically induced / Q000523:psychology*; D008803:Mianserin / Q000031:analogs & derivatives / Q000494:pharmacology; D000078785:Mirtazapine; D017374:Paroxetine / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D012559:Schizophrenia / Q000188:drug therapy; D012565:Schizophrenic Psychology; D020280:Sertraline / Q000494:pharmacology; D065852:Spatial Memory / Q000187:drug effects*; D000069470:Venlafaxine Hydrochloride / Q000494:pharmacology
chemical_list: D000928:Antidepressive Agents; D018691:Excitatory Amino Acid Antagonists; D015283:Citalopram; D008803:Mianserin; D017374:Paroxetine; D016291:Dizocilpine Maleate; D000069470:Venlafaxine Hydrochloride; D000078785:Mirtazapine; D016666:Fluvoxamine; D020280:Sertraline
keywords: Antidepressants; Parvalbumins; Schizophrenia; Spatial memory