title: Association between rheumatoid arthritis and systemic mastocytosis: a case report and literature review.
abstract: Classically, mast cells (MC) are considered as important actors of the innate immune response playing a pivotal role in IgE-mediated allergic and antiparasite responses. In the last two decades, many experimental evidences demonstrated that these hematopoietic-derived cells present in both connective and mucosal tissues are also key modulators of the adaptive immune response and could contribute to autoimmune disease notably in rheumatoid arthritis (RA). Recently, Bader-Meunier et al. reported a series of 31 patients suffering from inflammatory joint diseases associated with mastocytosis, suggesting that mastocytosis was associated with a higher prevalence in spondyloarthritis. We discuss here the possible link between chronic inflammatory arthritis and mastocytosis through the report of a clinical case describing a patient developing RA after a long history of mastocytosis. Of great interest, antihistamine treatment alone was sufficient to treat RA in this patient.
authors: UMR 7365 IMoPA CNRS-Université de Lorraine, Biopôle de l'Université de Lorraine, Campus biologie-santé, 54505, Vandœuvre-lès-Nancy cedex, France.
authors: Ichraq
authors: I
authors: Latar
authors: UMR 7365 IMoPA CNRS-Université de Lorraine, Biopôle de l'Université de Lorraine, Campus biologie-santé, 54505, Vandœuvre-lès-Nancy cedex, France.
authors: Meriem
authors: M
authors: Koufany
authors: UMR 7365 IMoPA CNRS-Université de Lorraine, Biopôle de l'Université de Lorraine, Campus biologie-santé, 54505, Vandœuvre-lès-Nancy cedex, France.
authors: Julie
authors: J
authors: Hablot
authors: Department of Rheumatology, Nancy University Hospital, 54511, Vandœuvre-lès-Nancy, France.
authors: Damien
authors: D
authors: Loeuille
authors: UMR 7365 IMoPA CNRS-Université de Lorraine, Biopôle de l'Université de Lorraine, Campus biologie-santé, 54505, Vandœuvre-lès-Nancy cedex, France.
authors: Patrick
authors: P
authors: Netter
authors: UMR 7365 IMoPA CNRS-Université de Lorraine, Biopôle de l'Université de Lorraine, Campus biologie-santé, 54505, Vandœuvre-lès-Nancy cedex, France.
authors: Jean-Yves
authors: JY
authors: Jouzeau
authors: Department of Rheumatology, Nancy University Hospital, 54511, Vandœuvre-lès-Nancy, France.
authors: Isabelle
authors: I
authors: Chary-Valckenaere
authors: UMR 7365 IMoPA CNRS-Université de Lorraine, Biopôle de l'Université de Lorraine, Campus biologie-santé, 54505, Vandœuvre-lès-Nancy cedex, France. david.moulin@univ-lorraine.fr.|Nancy, University Hospital, CHU de Nancy, Contrat d'interface, Nancy, F-54035, France. david.moulin@univ-lorraine.fr.
authors: David
authors: D
authors: Moulin
mesh_terms: D000368:Aged; D001172:Arthritis, Rheumatoid / Q000150:complications* / Q000188:drug therapy; D006633:Histamine Antagonists / Q000627:therapeutic use; D006801:Humans; D008297:Male; D034721:Mastocytosis, Systemic / Q000150:complications* / Q000188:drug therapy
chemical_list: D006633:Histamine Antagonists
keywords: Mast cells; Mastocytosis; Osteoporosis; Rheumatoid arthritis