title: TREM2 p.H157Y Variant and the Risk of Alzheimer's Disease: A Meta-Analysis Involving 14,510 Subjects.
abstract: We recently revealed that p.H157Y (rs2234255), a rare coding variant of triggering receptor expressed on myeloid cells 2 gene (TREM2), was associated with Alzheimer's disease (AD) susceptibility in Han Chinese. Contrastingly, although p.H157Y was previously identified in both AD cases and controls by several sequencing studies, no association of this variant with disease susceptibility was reported. To gain a credible conclusion on the association between p.H157Y and AD risk, a meta-analysis involving 7,102 cases and 7,408 controls was conducted. Our results indicated that p.H157Y was associated with an increased risk of AD (OR=3.65, 95% CI: 1.61-8.28; P=0.002), further establishing TREM2 as an important susceptibility gene for this disease.
authors: Department of Neurology, Nanjing First Hospital, Nanjing Medical University, Nanjing, Postal code: 210006; PR China. jt870918@163.com.
authors: Teng
authors: T
authors: Jiang
authors: Jian-Kang
authors: JK
authors: Hou
authors: Qing
authors: Q
authors: Gao
authors: Jin-Tai
authors: JT
authors: Yu
authors: Jun-Shan
authors: JS
authors: Zhou
authors: Hong-Dong
authors: HD
authors: Zhao
authors: . zhangyingdong@aliyun.com.
authors: Ying-Dong
authors: YD
authors: Zhang
mesh_terms: D000544:Alzheimer Disease / Q000235:genetics*; D044466:Asian People; D020022:Genetic Predisposition to Disease; D006801:Humans; D008562:Membrane Glycoproteins / Q000235:genetics*; D009154:Mutation / Q000235:genetics*; D011971:Receptors, Immunologic / Q000235:genetics*; D012307:Risk Factors
chemical_list: D008562:Membrane Glycoproteins; D011971:Receptors, Immunologic; C498715:TREM2 protein, human