title: Hypertension in Pregnant Renal and Liver Transplant Recipients.
abstract: BACKGROUND
  Pregnancies in transplant recipients involve risks for both grafts and the fetus, and need to be carefully managed. Hypertension is the most frequent complications in pregnant transplant recipients, especially in renal transplant recipients. Strict control of blood pressure is essential for a favorable obstetric outcome and long-term graft survival. The aim of the study was to evaluate the influence of hypertension on obstetric outcome and graft function in pregnant renal transplant recipients (RTR) or liver transplant recipients (LTR) in comparison with healthy pregnant women.
  
  
  METHODS
  This retrospective analysis included 46 RTR and 55 LTR who delivered between the years 2000 and 2014. The control group consisted of 187 nontransplant patients aged 20-45 years who delivered between 2010 and 2013. The analyzed group was divided into 2 subgroups: patients with hypertension and patients without hypertension. Descriptive data analysis, Fisher Exact test, unpaired Student t test, and analysis of the variance were performed.
  
  
  RESULTS
  Hypertension prevalence among the RTR, LTR, and control group was 73.5%, 34.5%, and 4.3% respectively. In the RTR group, the mean gestational age at delivery inp patients with hypertension vs without hypertension was 36 vs 34.5 weeks (P < .05); IUGR was diagnosed in 20% vs 8.5% pregnant women (P > .05). In the TRL group, the mean gestational age at delivery in group with hypertension vs without hypertension was 37 vs 3.9 weeks (P < .05); IUGR was diagnosed in 10.5% vs 5% of pregnant women (P > .05). Hypertension in RTR patients had a negative influence on graft function (P > .05).
  
  
  CONCLUSIONS
  Hypertension is common in organ recipients, and is associated with adverse pregnancy outcomes and loss of graft function.
authors: 1st Department Obstretrics and Gynecology, Warsaw Medical University, Warsaw, Poland. Electronic address: anna.madejj@yahoo.com.
authors: A
authors: A
authors: Madej
authors: 1st Department Obstretrics and Gynecology, Warsaw Medical University, Warsaw, Poland.
authors: B
authors: B
authors: Pietrzak
authors: 1st Department Obstretrics and Gynecology, Warsaw Medical University, Warsaw, Poland.
authors: N
authors: N
authors: Mazanowska
authors: Specialist Hospital Inflancka, Warsaw, Poland.
authors: T
authors: T
authors: Songin
authors: 1st Department Obstretrics and Gynecology, Warsaw Medical University, Warsaw, Poland.
authors: B
authors: B
authors: Kociszewska-Najman
authors: 1st Department Obstretrics and Gynecology, Warsaw Medical University, Warsaw, Poland.
authors: A
authors: A
authors: Cyganek
authors: 1st Department Obstretrics and Gynecology, Warsaw Medical University, Warsaw, Poland.
authors: Z
authors: Z
authors: Jabiry-Zieniewicz
authors: 1st Department Obstretrics and Gynecology, Warsaw Medical University, Warsaw, Poland.
authors: M
authors: M
authors: Wielgos
mesh_terms: D000328:Adult; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D016022:Case-Control Studies; D004359:Drug Therapy, Combination; D005260:Female; D005865:Gestational Age; D006801:Humans; D046110:Hypertension, Pregnancy-Induced / Q000188:drug therapy*; D016030:Kidney Transplantation; D016031:Liver Transplantation; D008875:Middle Aged; D011247:Pregnancy; D011256:Pregnancy Outcome; D011295:Prenatal Care; D012189:Retrospective Studies; D066027:Transplant Recipients; D055815:Young Adult
chemical_list: D000959:Antihypertensive Agents