title: Atopic Dermatitis: Update for Pediatricians.
abstract: Atopic dermatitis (AD) is a chronic, relapsing inflammatory skin disorder present in up to 20% of children. Recent advances implicate skin barrier dysfunction as central to disease pathogenesis. Genetic defects in the filaggrin gene, the product of which is important for maintaining the epidermal barrier, are a strong predisposing factor in the development of AD. In addition to reducing identifiable triggers, treatment should focus on the four clinical characteristics of eczema: emollients for dry skin, topical anti-inflammatory agents to reduce inflammation and itch, and strategies to reduce infection/colonization, which can include diluted bleach baths. New studies demonstrate that early emollient application from birth may prevent development of AD. [Pediatr Ann. 2016;45(8):e280-e286.].
authors: Katherine
authors: K
authors: Grey
authors: Sheilagh
authors: S
authors: Maguiness
mesh_terms: D000279:Administration, Cutaneous; D001494:Baths / Q000379:methods; D002648:Child; D003131:Combined Modality Therapy; D003876:Dermatitis, Atopic / Q000175:diagnosis / Q000209:etiology / Q000382:microbiology / Q000628:therapy; D003879:Dermatologic Agents / Q000627:therapeutic use; D003937:Diagnosis, Differential; D000091344:Filaggrin Proteins; D020022:Genetic Predisposition to Disease; D006801:Humans; D010372:Pediatrics; D012307:Risk Factors; D017592:Skin Care / Q000379:methods
chemical_list: D003879:Dermatologic Agents; C000717249:FLG protein, human; D000091344:Filaggrin Proteins