title: Schistosomal portal hypertension: Randomized trial comparing endoscopic therapy alone or preceded by esophagogastric devascularization and splenectomy.
abstract: Background. Upper gastrointestinal bleeding is a major cause of morbidity and mortality in patients with portal hypertension secondary to schistosomiasis mansoni.
  
  
  OBJECTIVE
  To evaluate the efficacy of combined surgery and sclerotherapy versus endoscopic treatment alone in the prophylaxis of esophageal variceal rebleeding due to portal hypertension in schistosomiasis.
  
  
  METHODS
  During a two-years period consecutive patients with schistosomiasis and a recent bleeding history were evaluated for prospective randomization. Absolute exclusion criteria were alcoholism or other liver diseases, whereas platelet count < 50,000/mm3, INR > 1.5 or presence of gastric varices were relative exclusion criteria. By random allocation 25 (group A) have received endoscopic sclerotherapy for esophageal varices alone and 22 (group B) combined treatment: esophagogastric devascularization with splenectomy followed by sclerotherapy. Interim analysis at 24 months has shown significant statistical differences between the groups and the randomization was halted.
  
  
  RESULTS
  Mean age was 38.9 ± 15.4 years and 58.46% were male. Mean follow-up was 38.6 ± 20.1 months. Endoscopic comparison of the size of esophageal varices before and after treatment did not show significant differences among the two groups. Treatment efficacy was assessed by the rate of recurrent esophageal variceal bleeding, that was more common in group A- 9/25 patients (36.0%) vs. 2/22 (9.0%) in group B (p = 0.029). Other complications were odynophagia, dysphagia and esophageal ulcer in group A and ascites and portal vein thrombosis in the surgical group.
  
  
  CONCLUSIONS
  In portal hypertension due to schistosomiasis, combined surgical and endoscopic treatment was more effective for the prevention of recurrent esophageal variceal bleeding.
authors: Gastroenterology Department, Federal University of Alagoas, - University Hospital Professor Dr Alberto Antunes.
authors: Celina Maria
authors: CM
authors: Costa Lacet
authors: Gastroenterology Department, Federal University of Alagoas, - University Hospital Professor Dr Alberto Antunes.
authors: João Batista
authors: JB
authors: Neto
authors: Gastroenterology Department, Federal University of Alagoas, - University Hospital Professor Dr Alberto Antunes.
authors: Laercio Tenório
authors: LT
authors: Ribeiro
authors: Gastroenterology Department, Federal University of Alagoas, - University Hospital Professor Dr Alberto Antunes.
authors: Francisco Silva
authors: FS
authors: Oliveira
authors: Gastroenterology Department, Federal University of Alagoas, - University Hospital Professor Dr Alberto Antunes.
authors: Rozangela Fernandes
authors: RF
authors: Wyszomirska
authors: Gastroenterology Department, Federal University of Alagoas, - University Hospital Professor Dr Alberto Antunes.
authors: Edna
authors: E
authors: Strauss
mesh_terms: D000328:Adult; D000818:Animals; D001938:Brazil; D003131:Combined Modality Therapy; D004932:Esophageal and Gastric Varices / Q000175:diagnosis / Q000469:parasitology / Q000628:therapy*; D005260:Female; D006471:Gastrointestinal Hemorrhage / Q000175:diagnosis / Q000469:parasitology / Q000628:therapy*; D016558:Hemostasis, Endoscopic / Q000009:adverse effects / Q000379:methods*; D006801:Humans; D006975:Hypertension, Portal / Q000175:diagnosis / Q000469:parasitology / Q000628:therapy*; D008109:Liver Diseases, Parasitic / Q000150:complications / Q000175:diagnosis / Q000469:parasitology*; D008297:Male; D008875:Middle Aged; D012008:Recurrence; D012550:Schistosoma mansoni / Q000472:pathogenicity*; D012555:Schistosomiasis mansoni / Q000150:complications / Q000175:diagnosis / Q000469:parasitology*; D015911:Sclerotherapy; D013156:Splenectomy / Q000009:adverse effects; D013997:Time Factors; D016896:Treatment Outcome; D055815:Young Adult