title: Pleural effusion as a manifestation of multiple myeloma.
abstract: Multiple myeloma is a clonal B-cell malignancy, characterised by proliferation of plasma cells and secretion of paraproteins. These plasma cells accumulate predominantly in the bone marrow; rarely, they invade other areas, especially the thorax. Myeloma presenting with a pleural effusion is rare and reported in only 6% of patients with myeloma. Such patients generally present late and have a poor prognosis. Here, we describe a patient presenting with a lung mass, renal failure and a massive unilateral pleural effusion due to multiple myeloma who was treated successfully.
authors: Department of Pulmonary Medicine, Aga Khan Hospital, Karachi, Pakistan.
authors: Nousheen
authors: N
authors: Iqbal
authors: Section of Histopatholgy, Department of Pathology and Laboratory Medicine, Aga Khan University, Karachi, Pakistan.
authors: Muhammad Usman
authors: MU
authors: Tariq
authors: Department of Pathology and Laboratory Medicine and Oncology, Aga Khan University, Karachi, Pakistan.
authors: Mohammad Usman
authors: MU
authors: Shaikh
authors: Department of Pulmonary Medicine, Aga Khan Hospital, Karachi, Pakistan.
authors: Hashir
authors: H
authors: Majid
mesh_terms: D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D000069286:Bortezomib / Q000008:administration & dosage; D003907:Dexamethasone / Q000008:administration & dosage; D003937:Diagnosis, Differential; D006801:Humans; D007676:Kidney Failure, Chronic / Q000150:complications; D000077269:Lenalidomide; D008175:Lung Neoplasms / Q000150:complications* / Q000188:drug therapy; D008297:Male; D009101:Multiple Myeloma / Q000150:complications* / Q000188:drug therapy; D010996:Pleural Effusion / Q000000981:diagnostic imaging / Q000209:etiology*; D013792:Thalidomide / Q000008:administration & dosage / Q000031:analogs & derivatives; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
chemical_list: D013792:Thalidomide; D000069286:Bortezomib; D003907:Dexamethasone; D000077269:Lenalidomide