title: Replication of α-amino acids via Strecker synthesis with amplification and multiplication of chiral intermediate aminonitriles.
abstract: Replication of chiral l- and d-α-(p-tolyl)glycine has been achieved in combination with the asymmetric induction, amplification and multiplication of their own chiral intermediates, l- and d-aminonitriles, in the solid-phase via the Strecker reaction between three achiral components, which is a plausible prebiotic mechanism for amino acid synthesis.
authors: Department of Materials Science and Engineering, University of Fukui, Bunkyo, Fukui 910-8507, Japan. tk@u-fukui.ac.jp.
authors: Shohei
authors: S
authors: Aiba
authors: Naoya
authors: N
authors: Takamatsu
authors: Taichiro
authors: T
authors: Sasai
authors: Yuji
authors: Y
authors: Tokunaga
authors: Tsuneomi
authors: T
authors: Kawasaki
mesh_terms: D000596:Amino Acids / Q000737:chemistry*; D005998:Glycine / Q000737:chemistry; D009570:Nitriles / Q000138:chemical synthesis / Q000737:chemistry*; D060327:Solid-Phase Synthesis Techniques; D013237:Stereoisomerism
chemical_list: D000596:Amino Acids; D009570:Nitriles; D005998:Glycine