title: Diagnostic Value of Contrast-Enhanced Sonography for Differentiation of Breast Lesions: A Meta-analysis.
abstract: OBJECTIVE
  The purpose of this study was to systematically review and evaluate the diagnostic accuracy of contrast-enhanced sonography in the differential diagnosis of benign and malignant breast lesions.
  
  
  METHODS
  The scientific literature databases PubMed and Embase were comprehensively searched for relevant studies before January 2015. Data were pooled to yield the summary sensitivity, specificity, and diagnostic odds ratio using meta-analysis software.
  
  
  RESULTS
  A total of 29 studies with 2296 lesions were included in the analysis. The pooled sensitivity and specificity were 0.88 (95% confidence interval [CI], 0.86-0.90; inconsistency index [I(2)] = 77.9%) and 0.80 (95% CI, 0.78-0.83; I(2) = 84.0%), respectively. The pooled diagnostic odds ratio was 30.35 (95% CI, 15.75-58.48; I(2)= 82.1%), and the area under the summary receiver operating characteristic curve was 0.9115 (SE, 0.0243).
  
  
  CONCLUSIONS
  The comprehensive results suggest that contrast-enhanced sonography could be a potentially effective method for differential diagnosis of benign and malignant breast lesions.
authors: State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, China, Department of Oncology, West China Hospital, Sichuan University, Chengdu, China, Collaborative Innovation Center for Biotherapy, Chengdu, China drmaxuelei@gmail.com.
authors: Xuelei
authors: X
authors: Ma
authors: West China School of Medicine, West China Hospital, Sichuan University, Chengdu, China.
authors: Rongjun
authors: R
authors: Liu
authors: State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, China, Collaborative Innovation Center for Biotherapy, Chengdu, China.
authors: Chenjing
authors: C
authors: Zhu
authors: West China School of Medicine, West China Hospital, Sichuan University, Chengdu, China.
authors: Jing
authors: J
authors: Zhang
authors: Department of Ultrasound, West China Hospital, Sichuan University, Chengdu, China.
authors: Wenwu
authors: W
authors: Ling
mesh_terms: D001943:Breast Neoplasms / Q000000981:diagnostic imaging*; D003287:Contrast Media; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D016217:Ultrasonography, Mammary / Q000379:methods*
chemical_list: D003287:Contrast Media
keywords: breast cancer; breast ultrasound; contrast-enhanced sonography; diagnosis; meta-analysis