title: To Assess the Association between Glucose Metabolism and Ectopic Lipid Content in Different Clinical Classifications of PCOS.
abstract: OBJECTIVE
  There are emerging data indicating an association between PCOS (polycystic ovary syndrome) and metabolic derangements with potential impact on its clinical presentation. This study aims to evaluate the pathophysiological processes beyond PCOS with particular focus on carbohydrate metabolism, ectopic lipids and their possible interaction. Differences between the two established classifications of the disease should be additionally evaluated.
  
  
  METHODS
  A metabolic characterization was performed in 53 untreated PCOS patients as well as 20 controls including an extended oral glucose tolerance test (OGTT, to assess insulin sensitivity, secretion and ß-cell function) in addition to a detailed examination of ectopic lipid content in muscle and liver by nuclear magnetic resonance spectroscopy.
  
  
  RESULTS
  Women with PCOS classified by the original NIH 1990 definition showed a more adverse metabolic risk profile compared to women characterized by the additional Rotterdam 2003 phenotypes. Subtle metabolic derangements were observed in both subgroups, including altered shapes of OGTT curves, impaired insulin action and hyperinsulinemia due to increased secretion and attenuated hepatic extraction. No differences were observed for ectopic lipids between the groups. However, particularly hepatocellular lipid content was significantly related to clinical parameters of PCOS like whole body insulin sensitivity, dyslipidemia and free androgen index.
  
  
  CONCLUSIONS
  Subtle alterations in carbohydrate metabolism are present in both PCOS classifications, but more profound in subjects meeting the NIH 1990 criteria. Females with PCOS and controls did not differ in ectopic lipids, however, liver fat was tightly related to hyperandrogenism and an adverse metabolic risk profile.
authors: Department of Obstetrics and Gynecology, Division of Gynecologic Endocrinology and Reproductive Medicine, Medical University of Vienna, Vienna, Austria.
authors: Christian S
authors: CS
authors: Göbl
authors: Department of Obstetrics and Gynecology, Division of Gynecologic Endocrinology and Reproductive Medicine, Medical University of Vienna, Vienna, Austria.
authors: Johannes
authors: J
authors: Ott
authors: Department of Internal Medicine III, Division of Endocrinology and Metabolism, Unit of Gender Medicine, Medical University of Vienna, Vienna, Austria.
authors: Latife
authors: L
authors: Bozkurt
authors: Department of Obstetrics and Gynecology, Division of Gynecologic Endocrinology and Reproductive Medicine, Medical University of Vienna, Vienna, Austria.
authors: Michael
authors: M
authors: Feichtinger
authors: Department of Obstetrics and Gynecology, Division of Gynecologic Endocrinology and Reproductive Medicine, Medical University of Vienna, Vienna, Austria.
authors: Victoria
authors: V
authors: Rehmann
authors: Department of Obstetrics and Gynecology, Division of Gynecologic Endocrinology and Reproductive Medicine, Medical University of Vienna, Vienna, Austria.
authors: Anna
authors: A
authors: Cserjan
authors: Department of Obstetrics and Gynecology, Division of Gynecologic Endocrinology and Reproductive Medicine, Medical University of Vienna, Vienna, Austria.
authors: Maike
authors: M
authors: Heinisch
authors: Department of Obstetrics and Gynecology, Division of Gynecologic Endocrinology and Reproductive Medicine, Medical University of Vienna, Vienna, Austria.
authors: Helmut
authors: H
authors: Steinbrecher
authors: High Field Magnetic Resonance Centre of Excellence, Medical University of Vienna, Vienna, Austria.
authors: Ivica
authors: I
authors: JustKukurova
authors: High Field Magnetic Resonance Centre of Excellence, Medical University of Vienna, Vienna, Austria.
authors: Radka
authors: R
authors: Tuskova
authors: Department of Internal Medicine III, Division of Endocrinology and Metabolism, Unit of Gender Medicine, Medical University of Vienna, Vienna, Austria.
authors: Michael
authors: M
authors: Leutner
authors: Department of Obstetrics and Gynecology, Division of Gynecologic Endocrinology and Reproductive Medicine, Medical University of Vienna, Vienna, Austria.
authors: Elisabeth
authors: E
authors: Vytiska-Binstorfer
authors: Department of Obstetrics and Gynecology, Division of Gynecologic Endocrinology and Reproductive Medicine, Medical University of Vienna, Vienna, Austria.
authors: Christine
authors: C
authors: Kurz
authors: Department of Obstetrics and Gynecology, Division of Gynecologic Endocrinology and Reproductive Medicine, Medical University of Vienna, Vienna, Austria.
authors: Andrea
authors: A
authors: Weghofer
authors: Metabolic Unit, Institute of Neuroscience, National Research Council, Padova, Italy.
authors: Andrea
authors: A
authors: Tura
authors: Department of Obstetrics and Gynecology, Division of Gynecologic Endocrinology and Reproductive Medicine, Medical University of Vienna, Vienna, Austria.
authors: Christian
authors: C
authors: Egarter
authors: Department of Internal Medicine III, Division of Endocrinology and Metabolism, Unit of Gender Medicine, Medical University of Vienna, Vienna, Austria.
authors: Alexandra
authors: A
authors: Kautzky-Willer
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D005260:Female; D005947:Glucose / Q000378:metabolism*; D005951:Glucose Tolerance Test; D006801:Humans; D007328:Insulin / Q000378:metabolism; D050417:Insulin-Secreting Cells / Q000473:pathology; D050356:Lipid Metabolism; D008099:Liver / Q000378:metabolism; D009132:Muscles / Q000378:metabolism; D010641:Phenotype; D011085:Polycystic Ovary Syndrome / Q000378:metabolism* / Q000473:pathology; D055815:Young Adult
chemical_list: D007328:Insulin; D005947:Glucose