title: T1mapping for diagnosis of mild chronic pancreatitis.
abstract: To determine if the T1relaxation time of the pancreas can detect parenchymal changes in mild chronic pancreatitis (CP).
  
  
  
  This Institutional Review Board (IRB)-approved, Health Insurance Portability and Accountability Act (HIPAA)-compliant retrospective study analyzed 98 patients with suspected mild CP. Patients were grouped as normal (n = 53) or mild CP (n = 45) based on history, presenting symptomatology, and concordant findings on both the secretin-enhanced magnetic resonance cholangiopancreatography (S-MRCP) and endoscopic retrograde cholangiopancreatography (ERCP). T1maps were obtained in all patients using the same 3D gradient echo technique on the same 3T scanner. T1relaxation times, fat signal fraction (FSF), and anterior-posterior (AP) diameter were correlated with the clinical diagnosis of CP.
  
  
  
  There was a significant difference (P < 0.0001) in the T1relaxation times between the control (mean = 797 msec, 95% confidence interval [CI]: 730, 865) and mild CP group (mean = 1099 msec, 95% CI: 1032, 1166). A T1relaxation time threshold value of 900 msec was 80% sensitive (95% CI: 65, 90) and 69% specific (95% CI: 56, 82) for the diagnosis of mild CP (area under the curve [AUC]: 0.81). Multiple regression analysis showed that T1relaxation time was the only statistically significant variable correlating with the diagnosis of CP (P < 0.0001). T1relaxation times showed a weak positive correlation with the pancreatic FSF (ρ = 0.33, P = 0.01) in the control group, but not in the mild CP group.
  
  
  
  The T1relaxation time of the pancreatic parenchyma was significantly increased in patients with mild CP. Therefore, T1mapping might be used as a practical quantitative imaging technique for the evaluation of suspected mild CP.
  
  
  
  3 J. Magn. Reson. Imaging 2017;45:1171-1176.
authors: Department of Radiology and Clinical Sciences, Indiana University School of Medicine, Indianapolis, Indiana, USA.
authors: Temel
authors: T
authors: Tirkes
authors: Department of Radiology and Clinical Sciences, Indiana University School of Medicine, Indianapolis, Indiana, USA.
authors: Chen
authors: C
authors: Lin
authors: Department of Medicine, Division of Gastroenterology, Indiana University School of Medicine, Indianapolis, Indiana, USA.
authors: Evan L
authors: EL
authors: Fogel
authors: Department of Medicine, Division of Gastroenterology, Indiana University School of Medicine, Indianapolis, Indiana, USA.
authors: Stuart S
authors: SS
authors: Sherman
authors: Department of Radiology, Guangdong General Hospital, Guangdong Academy of Medical Sciences No 106, Guangzhou, GuangDong, China.
authors: Qiushi
authors: Q
authors: Wang
authors: Department of Radiology and Clinical Sciences, Indiana University School of Medicine, Indianapolis, Indiana, USA.
authors: Kumaresan
authors: K
authors: Sandrasegaran
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002760:Cholangiopancreatography, Endoscopic Retrograde / Q000379:methods*; D049448:Cholangiopancreatography, Magnetic Resonance / Q000379:methods*; D005260:Female; D006801:Humans; D021621:Imaging, Three-Dimensional / Q000379:methods; D008297:Male; D008875:Middle Aged; D010179:Pancreas / Q000000981:diagnostic imaging; D050500:Pancreatitis, Chronic / Q000000981:diagnostic imaging*; D012189:Retrospective Studies; D012633:Secretin; D055815:Young Adult
chemical_list: D012633:Secretin
keywords: MRCP; MRI; T1 mapping; chronic pancreatitis