title: Impairment of fine motor dexterity in mild cognitive impairment and Alzheimer's disease dementia: association with activities of daily living.
abstract: OBJECTIVE
  Cognitive impairment is a hallmark of mild cognitive impairment (MCI) and Alzheimer's disease dementia (AD). Although the cognitive profile of these patients and its association with activities of daily living (ADLs) is well documented, few studies have assessed deficits in fine motor dexterity and their association with ADL performance. The objective of this research paper is to evaluate fine motor dexterity performance among MCI and AD patients and to investigate its association with different aspects of ADLs.
  
  
  METHODS
  We assessed normal aging controls, patients with multiple- and single-domain amnestic MCI (aMCI), and patients with mild AD. Fine motor dexterity was measured with the Nine-Hole Peg Test and cognitive functioning by the Mattis Dementia Rating Scale. We analyzed the data using general linear models.
  
  
  RESULTS
  Patients with AD or multiple-domain aMCI had slower motor responses when compared to controls. AD patients were slower than those with single-domain aMCI. We found associations between cognition and instrumental ADLs, and between fine motor dexterity and self-care ADLs.
  
  
  CONCLUSIONS
  We observed progressive slowing of fine motor dexterity along the normal aging-MCI-AD spectrum, which was associated with autonomy in self-care ADLs.
authors: Instituto Nacional de Ciências e Tecnologia em Medicina Molecular (INCT-MM), Faculdade de Medicina, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, MG, Brazil.|Departamento de Psicologia, Faculdade de Ciências Médicas de Minas Gerais (FCMMG), Belo Horizonte, MG, Brazil.
authors: Jonas J
authors: JJ
authors: de Paula
authors: Instituto Nacional de Ciências e Tecnologia em Medicina Molecular (INCT-MM), Faculdade de Medicina, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, MG, Brazil.|Departamento de Educação Física, Universidade Federal de Viçosa (UFV), Viçosa, MG, Brazil.
authors: Maicon R
authors: MR
authors: Albuquerque
authors: Instituto Nacional de Ciências e Tecnologia em Medicina Molecular (INCT-MM), Faculdade de Medicina, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, MG, Brazil.|Departamento de Educação Física, UFMG, Belo Horizonte, MG, Brazil.
authors: Guilherme M
authors: GM
authors: Lage
authors: Instituto Nacional de Ciências e Tecnologia em Medicina Molecular (INCT-MM), Faculdade de Medicina, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, MG, Brazil.|Departamento de Clínica Médica, Faculdade de Medicina, UFMG, Belo Horizonte, MG, Brazil.
authors: Maria A
authors: MA
authors: Bicalho
authors: Instituto Nacional de Ciências e Tecnologia em Medicina Molecular (INCT-MM), Faculdade de Medicina, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, MG, Brazil.|Departamento de Saúde Mental, Faculdade de Medicina, UFMG, Belo Horizonte, MG, Brazil.
authors: Marco A
authors: MA
authors: Romano-Silva
authors: Instituto Nacional de Ciências e Tecnologia em Medicina Molecular (INCT-MM), Faculdade de Medicina, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, MG, Brazil.|Departamento de Saúde Mental, Faculdade de Medicina, UFMG, Belo Horizonte, MG, Brazil.
authors: Leandro F
authors: LF
authors: Malloy-Diniz
mesh_terms: D000203:Activities of Daily Living / Q000523:psychology*; D000375:Aging / Q000502:physiology / Q000523:psychology; D000544:Alzheimer Disease / Q000503:physiopathology*; D016022:Case-Control Studies; D060825:Cognitive Dysfunction / Q000503:physiopathology*; D003430:Cross-Sectional Studies; D006801:Humans; D016014:Linear Models; D009048:Motor Skills / Q000502:physiology*; D009483:Neuropsychological Tests; D011569:Psychiatric Status Rating Scales; D012648:Self Care / Q000523:psychology