title: Survival Analysis over 28 Years of 173,378 Patients with Hepatocellular Carcinoma in Japan.
abstract: BACKGROUND
  Beginning in 1967, the Liver Cancer Study Group of Japan (LCSGJ) started a nationwide prospective registry of all patients with hepatocellular carcinoma (HCC) diagnosed at more than 700 institutions. To determine the effectiveness of surveillance and treatment methods longitudinally, we analyzed improvements over time in overall survival (OS) of 173,378 patients with HCC prospectively entered into the LCSGJ registry between 1978 and 2005.
  
  
  METHODS
  All patients from more than 700 institutions throughout Japan with HCC were entered into the LCSGJ registry. Patients were grouped by years of diagnosis, with OS and 5-year OS rates being calculated. We also assessed OS and 5-year OS rates in patients who underwent resection, local ablation, transarterial chemoembolization (TACE), and hepatic arterial infusion chemotherapy (HAIC) and in those with baseline serum alpha-fetoprotein (AFP) levels ≥400 ng/ml.
  
  
  RESULTS
  The 5- and 10-year OS rates in the cohort of 173,378 patients were 37.9% and 16.5%, respectively. However, over time, the mean maximum tumor size decreased significantly, whereas 5-year OS rates and median survival time increased significantly. Similar findings were observed separately in patients who underwent resection, local ablation, TACE, and HAIC, as well as in patients with AFP levels ≥400 ng/ml.
  
  
  CONCLUSIONS
  The establishment of a nationwide HCC surveillance program in Japan has contributed to longer median OS and increased OS rates in patients diagnosed with this disease. These findings suggest that the establishment of a surveillance program in other countries with patients at risk for HCC may provide significant survival benefits.
authors: Department of Gastroenterology and Hepatology, Kindai University Faculty of Medicine, Osaka-Sayama, Tokyo, Japan.
authors: Masatoshi
authors: M
authors: Kudo
authors: Department of Gastroenterology and Hepatology, Musashino Red Cross Hospital, Musashino, Japan.
authors: Namiki
authors: N
authors: Izumi
authors: Department of Pathology, Keio University School of Medicine, Shinjuku, Japan.
authors: Michiie
authors: M
authors: Sakamoto
authors: Department of Biostatistics, School of Health Sciences and Nursing, University of Tokyo, Tokyo, Japan.
authors: Yutaka
authors: Y
authors: Matsuyama
authors: Department of Gastroenterology, Shizuoka Hospital Juntendo University School of Medicine, Shizuoka, Japan.
authors: Takafumi
authors: T
authors: Ichida
authors: Department of Clinical Laboratory Medicine, Kurume University Hospital, Kurume, Japan.
authors: Osamu
authors: O
authors: Nakashima
authors: Department of Radiology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan.
authors: Osamu
authors: O
authors: Matsui
authors: Department of Surgery, Kobe University Graduate School of Medicine, Kobe, Japan.
authors: Yonson
authors: Y
authors: Ku
authors: Department of Hepato-Biliary and Pancreatic Surgery, University of Tokyo Graduate School of Medicine, Tokyo, Japan.
authors: Norihiro
authors: N
authors: Kokudo
authors: Department of Surgery, Japanese Red Cross Medical Center, Tokyo, Japan.
authors: Masatoshi
authors: M
authors: Makuuchi
keywords: Hepatic arterial infusion chemotherapy; Hepatocellular carcinoma; Liver Cancer Study Group of Japan; Nationwide survey; Overall survival