title: Discovery of anti-inflammatory role of prostaglandin D2.
abstract: Nonsteroidal anti-inflammatory drugs (NSAIDs) including aspirin are one of the most frequently used classes of drug worldwide and inhibit prostaglandin (PG) production by inhibiting cyclooxygenase activity. Although NSAIDs are broadly used against inflammatory diseases, they have side effects including alimentary canal disorders, kidney damage, infection and cardiovascular disorders. Thus, it is necessary to elucidate the pathophysiological role of each PG in various diseases to develop better therapies with fewer and milder side effects. PGD2is a PG that was identified in 1973 by Hamberg and is produced by the activities of cyclooxygenase and either hematopoietic or lipocalin-type PGD synthase. PGD2exerts its physiological effects by stimulating two distinct G protein-coupled receptors, namely D prostanoid receptor (DP) and chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTH2). The physiological role of PGD2remains controversial. Some studies have reported that PGD2has bronchoconstrictory and pro-inflammatory effects inducing immune cell accumulation. In contrast, other groups have reported that PGD2has anti-inflammatory effects by inhibiting the recruitment of dendritic cells and neutrophils. We have investigated the pathophysiological role of PGD2using various disease models and reported on its anti-inflammatory actions. Here, we review the anti-inflammatory roles of PGD2and the underlying mechanisms.
authors: Department of Animal Radiology, Graduate School of Agriculture and Life Sciences, The University of Tokyo, Tokyo 113-8657, Japan.
authors: Takahisa
authors: T
authors: Murata
authors: Toko
authors: T
authors: Maehara
mesh_terms: D055371:Acute Lung Injury / Q000378:metabolism; D000818:Animals; D002199:Capillary Permeability; D003092:Colitis / Q000378:metabolism; D003872:Dermatitis / Q000378:metabolism; D007249:Inflammation / Q000276:immunology / Q000378:metabolism; D051379:Mice; D009369:Neoplasms / Q000098:blood supply / Q000276:immunology / Q000378:metabolism; D009389:Neovascularization, Pathologic / Q000378:metabolism; D015230:Prostaglandin D2 / Q000378:metabolism* / Q000494:pharmacology; D011971:Receptors, Immunologic / Q000378:metabolism; D011982:Receptors, Prostaglandin / Q000378:metabolism
chemical_list: D011971:Receptors, Immunologic; D011982:Receptors, Prostaglandin; D015230:Prostaglandin D2; C036293:prostaglandin D2 receptor