title: Does exposure to inhalation anesthesia gases change the ratio of X-bearing sperms and Y-bearing Sperms? A worth exploring project into an uncharted domain.
abstract: According to recent surveys performed in United States and India, anesthesia care providers were observed to have sired female offspring in a higher proportion than male offspring as their firstborn progeny; however, the reasons for the skew are not clear. Our hypothesis is that the underlying biological evidence may be elucidated by unraveling differences (if any) between the concentrations of X-bearing sperms and Y-bearing sperms in the semen samples obtained from males exposed to varied levels of anesthetics in their lifetimes. Therefore, the objectives of the envisaged study would be to conduct a three-stage investigative study on in-vitro human semen samples to determine (a) X-bearing sperms and Y-bearing sperms concentrations' ratio in male pediatric anesthesia care providers' semen samples, (b) changes in X-bearing sperms and Y-bearing sperms concentrations' ratios between the pre-rotation and post-rotation semen samples of male medical student volunteers/observers, and (c) changes in X-bearing sperms and Y-bearing sperms concentrations' ratios between the pre-operative and post-operative day-3 semen samples of male patients presenting for outpatient procedures under inhalational anesthesia. The expected outcomes would be (a) linear and positive correlation of the anesthetic gas usage (exposure) with increased X-bearing sperms/Y-bearing sperms ratio in post-anesthesia day 3 sample as compared to the baseline preoperative sample, (b) linear and positive correlation of the anesthetic gas usage (exposure) with increased X-bearing sperms/Y-bearing sperms ratio in post-rotation sample as compared to the baseline sample, and (c) observation of high X-bearing sperms/Y-bearing sperms ratio in the pediatric anesthesia care providers. In summary, effects (if any) of occupational or personal exposure to inhalational anesthetic gases on the X-bearing sperms and Y-bearing sperms ratio is a worthy project wherein lots of questions that have arisen over decades could find the path to their definitive answers, based on envisaged laboratory investigations into this uncharted domain.
authors: Wayne State University/Detroit Medical Center, Detroit, MI, United States. Electronic address: dgupta@med.wayne.edu.
authors: Deepak
authors: D
authors: Gupta
authors: Wayne State University/Detroit Medical Center, Detroit, MI, United States.
authors: George
authors: G
authors: Mckelvey
authors: Wayne State University/Detroit Medical Center, Detroit, MI, United States.
authors: Edward
authors: E
authors: Kaminski
authors: Wayne State University/Detroit Medical Center, Detroit, MI, United States.
authors: Maria Markakis
authors: MM
authors: Zestos
mesh_terms: D018685:Anesthetics, Inhalation / Q000494:pharmacology*; D015992:Body Mass Index; D041321:Chromosomes, Human, X; D041322:Chromosomes, Human, Y; D005260:Female; D005740:Gases; D064368:Healthy Volunteers; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007194:India; D008297:Male; D008962:Models, Theoretical; D016273:Occupational Exposure; D000072143:Pediatricians; D011184:Postoperative Period; D057234:Preoperative Period; D012661:Semen / Q000187:drug effects*; D012744:Sex Ratio; D013094:Spermatozoa / Q000187:drug effects*; D013337:Students, Medical; D014481:United States
chemical_list: D018685:Anesthetics, Inhalation; D005740:Gases