title: Quorum sensing signal-response systems in Gram-negative bacteria.
abstract: Bacteria use quorum sensing to orchestrate gene expression programmes that underlie collective behaviours. Quorum sensing relies on the production, release, detection and group-level response to extracellular signalling molecules, which are called autoinducers. Recent work has discovered new autoinducers in Gram-negative bacteria, shown how these molecules are recognized by cognate receptors, revealed new regulatory components that are embedded in canonical signalling circuits and identified novel regulatory network designs. In this Review we examine how, together, these features of quorum sensing signal-response systems combine to control collective behaviours in Gram-negative bacteria and we discuss the implications for host-microbial associations and antibacterial therapy.
authors: Department of Biology, Ludwig-Maximilians-University Munich, Biocenter, 82152 Martinsried, Germany.
authors: Kai
authors: K
authors: Papenfort
authors: Howard Hughes Medical Institute; Department of Molecular Biology, 329 Lewis Thomas Laboratories, Washington Road, Princeton University, Princeton, New Jersey 08544, USA.
authors: Bonnie L
authors: BL
authors: Bassler
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology; D001426:Bacterial Proteins / Q000378:metabolism; D006090:Gram-Negative Bacteria / Q000737:chemistry / Q000235:genetics / Q000502:physiology*; D010675:Pheromones / Q000737:chemistry / Q000378:metabolism*; D053038:Quorum Sensing; D015398:Signal Transduction
chemical_list: D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D010675:Pheromones