title: Extracellular Vesicles Move Toward Use in Clinical Laboratories.
abstract: Extracellular vesicles (EVs) are membranous particles found in a variety of biofluids that encapsulate molecular information from the cell, which they originate from. This rich source of information that is easily obtained can then be mined to find diagnostic biomarkers. This article explores the current biological understanding of EVs and specific methods to isolate and analyze them. A case study of a company leading the charge in using EVs in diagnostic assays is provided.
authors: PGXL Technologies, 201 East Jefferson Street, Suite 306, Louisville, KY 40202, USA; Department of Engineering, University of Louisville, Louisville, Kentucky, USA. Electronic address: lindsay.strotman@pgxlab.com.
authors: Lindsay N
authors: LN
authors: Strotman
authors: PGXL Technologies, 201 East Jefferson Street, Suite 306, Louisville, KY 40202, USA; Department of Pathology and Laboratory Medicine, University of Louisville School of Medicine, 511 S Floyd Street, MDR Building, Room 204, Louisville, KY 40292, USA.
authors: Mark W
authors: MW
authors: Linder
mesh_terms: D015415:Biomarkers / Q000032:analysis; D064790:Clinical Laboratory Services; D000067128:Extracellular Vesicles / Q000737:chemistry*; D006801:Humans
chemical_list: D015415:Biomarkers
keywords: Extracellular vesicle (EV); Liquid biopsy; Oncology