title: Glycated albumin is superior to glycated hemoglobin for glycemic control assessment at an early stage of diabetes treatment: A multicenter, prospective study.
abstract: This study was to determine whether serum glycated albumin (GA) was a better indicator of glycemic control than hemoglobin A1c (HbA1c) when starting a new treatment regimen for type 2 diabetes.
  
  
  
  Newly diagnosed type 2 diabetes patients, or patients who had poor glycemic control with oral hypoglycemic agents, were enrolled at 10 hospitals in Beijing. Serum GA, HbA1c, fasting blood glucose (FBG), and C-peptide were assayed on Days 0, 14, 28, and 91 after treatment.
  
  
  
  Four hundred ninety-nine patients were enrolled. Mean FBG, GA and HbA1c decreased significantly in patients at Days 14, 28, and 91. In patients with improved glycemic control, the reduction of GA and HbA1c levels was 10.5±13.3% vs. 5.1±5.4% on Day 14, 16.0±13.4% vs. 9.0±7.0% on Day 28, and 18.0±16.7% vs. 18.3±9.4% on Day 91, respectively, compared with baseline values. Changes in GA on Day 14, 28 and 91 were all closely correlated with changes in HbA1c on Day 91. Change in GA on Day 14 was correlated with treatment effectiveness evaluated by HbA1c on Day 91.
  
  
  
  GA may be a useful marker for assessing glycemic control at an early stage of new diabetes treatment and assist in guiding adjustments to treatment and therapy.
authors: Department of Endocrinology, Chinese PLA General Hospital, Beijing, 100853, China. Electronic address: lujuming301@126.com.
authors: Ju-Ming
authors: JM
authors: Lu
authors: Department of Endocrinology, Beijing, Peking University People's Hospital, Beijing 100035, China. Electronic address: jilinong@gmail.com.
authors: Li-Nong
authors: LN
authors: Ji
authors: Department of Endocrinology, Beijing, Pinggu Hospital, Beijing, 101200, China.
authors: Yu-Feng
authors: YF
authors: Li
authors: Department of Endocrinology, Beijing, The Second Artillery General Hospital of PLA, 100088, China.
authors: Quan-Min
authors: QM
authors: Li
authors: Department of Endocrinology, Beijing, Beijing, Shijingshan Hospital, 100049, China.
authors: Shan-Shan
authors: SS
authors: Lin
authors: Department of Endocrinology, General Hospital of Beijing Military Command, Beijing, 100010, China.
authors: Xiao-Feng
authors: XF
authors: Lv
authors: Department of Endocrinology, Xuanwu Hospital of Capital Medical University, Beijing, 100053, China.
authors: Li
authors: L
authors: Wang
authors: Department of Endocrinology, Beijing Chaoyang Hospital of Capital Medical University, Beijing, 100023, China.
authors: Yuan
authors: Y
authors: Xu
authors: Department of Endocrinology, Peking University First Hospital, Beijing, 100034, China.
authors: Xiao-Hui
authors: XH
authors: Guo
authors: Department of Endocrinology, Navy General Hospital, Beijing, 100048, China.
authors: Qi-Yu
authors: QY
authors: Guo
authors: Department of Endocrinology, Guang An Men Hospital, China Academy of Chinese Medical Science, Beijing, 102600, China.
authors: Li
authors: L
authors: Ma
authors: Department of Endocrinology, Chinese PLA General Hospital, Beijing, 100853, China.
authors: Jin
authors: J
authors: Du
authors: Department of Endocrinology, Beijing, Peking University People's Hospital, Beijing 100035, China.
authors: Ying-Li
authors: YL
authors: Chen
authors: Department of Endocrinology, Beijing, Pinggu Hospital, Beijing, 101200, China.
authors: Cui-Ling
authors: CL
authors: Zhao
authors: Department of Endocrinology, Beijing, The Second Artillery General Hospital of PLA, 100088, China.
authors: Qiu-Lan
authors: QL
authors: Zhang
authors: Department of Endocrinology, Beijing, Beijing, Shijingshan Hospital, 100049, China.
authors: Qi-Mei
authors: QM
authors: She
authors: Department of Endocrinology, General Hospital of Beijing Military Command, Beijing, 100010, China.
authors: Xiu-Min
authors: XM
authors: Jiao
authors: Department of Endocrinology, Xuanwu Hospital of Capital Medical University, Beijing, 100053, China.
authors: Mei-Hua
authors: MH
authors: Lu
authors: Department of Endocrinology, Beijing Chaoyang Hospital of Capital Medical University, Beijing, 100023, China.
authors: Rong-Qing
authors: RQ
authors: Pan
authors: Department of Endocrinology, Peking University First Hospital, Beijing, 100034, China.
authors: Ying
authors: Y
authors: Gao
mesh_terms: D001786:Blood Glucose / Q000032:analysis; D003924:Diabetes Mellitus, Type 2 / Q000175:diagnosis / Q000188:drug therapy*; D005260:Female; D006442:Glycated Hemoglobin / Q000032:analysis*; D017127:Glycation End Products, Advanced; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012709:Serum Albumin / Q000032:analysis*; D000093423:Glycated Serum Albumin
chemical_list: D001786:Blood Glucose; D006442:Glycated Hemoglobin; D017127:Glycation End Products, Advanced; D012709:Serum Albumin; D000093423:Glycated Serum Albumin
keywords: Diabetes; Fasting blood glucose; Glycated albumin; Glycated hemoglobin; Oral hypoglycemic agents