title: Constitutive expression of genes encoding notch receptors and ligands in developing lymphocytes, nTreg cells and dendritic cells in the human thymus.
abstract: The thymus is the site of T cell maturation. Notch receptors (Notch1-4) and ligands (DLL1-3 and Jagged1-2) constitute one of several pathways involved in this process. Our data revealed differential constitutive expression of Notch genes and ligands in T lymphocytes and thymic dendritic cells (tDCs), suggesting their participation in human thymocyte maturation. nTreg analyses indicated that the Notch components function in parallel to promote maturation in the thymus.
authors: Laboratory of Medical Investigation in Dermatology and Immunodeficiencies (LIM56), School of Medicine - USP, São Paulo, Brazil; Laboratory of Pathology of Transmissible Diseases, School of Medicine - USP, São Paulo, Brazil.
authors: Luciana
authors: L
authors: Bento-de-Souza
authors: Laboratory of Medical Investigation in Dermatology and Immunodeficiencies (LIM56), School of Medicine - USP, São Paulo, Brazil.
authors: Jefferson R
authors: JR
authors: Victor
authors: Heart Hospital - Hcor, São Paulo, Brazil.
authors: Luiz C
authors: LC
authors: Bento-de-Souza
authors: Heart Hospital - Hcor, São Paulo, Brazil.
authors: Magaly
authors: M
authors: Arrais-Santos
authors: Laboratory of Medical Investigation in Dermatology and Immunodeficiencies (LIM56), School of Medicine - USP, São Paulo, Brazil.
authors: Andréia C
authors: AC
authors: Rangel-Santos
authors: Laboratory of Medical Investigation in Dermatology and Immunodeficiencies (LIM56), School of Medicine - USP, São Paulo, Brazil.
authors: Érica
authors: É
authors: Pereira-Costa
authors: Institute of Integrative Medicine Professor Fernando Figueira - IMIP, Recife, PE, Brazil.
authors: Elaine
authors: E
authors: Raniero-Fernandes
authors: Laboratory of Pathology of Transmissible Diseases, School of Medicine - USP, São Paulo, Brazil.
authors: Maria I
authors: MI
authors: Seixas-Duarte
authors: Institute of Integrative Medicine Professor Fernando Figueira - IMIP, Recife, PE, Brazil.
authors: João B
authors: JB
authors: Oliveira-Filho
authors: Laboratory of Medical Investigation in Dermatology and Immunodeficiencies (LIM56), School of Medicine - USP, São Paulo, Brazil; Heart Hospital - Hcor, São Paulo, Brazil.
authors: Alberto J
authors: AJ
authors: Silva Duarte
keywords: Notch; TDCS; Thymus; Treg