title: Effect of Afobazole and Betaine on Cognitive Disorders in the Offspring of Rats with Streptozotocin-Induced Diabetes and Their Relationship with DNA Damage.
abstract: Cognitive activity in 60-day-old offspring of rats (intrauterine development in experimental streptozotocin-induced diabetes) was studied on the model of food-seeking behavior under conditions of free choice in a 6-arm maze. The formation of the food-procuring skill was significantly delayed, which attests to impairment of cognitive functions in these animals. Peroral administration of afobazole (10 and 50 mg/kg) and betaine (50 and 100 mg/kg) significantly and dose-dependently alleviated this disorder. Correlation analysis of the data on delayed formation of a food-procuring skill and results of DNA comet attests to a strong relationship between DNA damage in cells of the embryo and placenta during intrauterine development and cognitive dysfunction in the postnatal offspring of animals with streptozotocin-induced diabetes.
authors: V. V. Zakusov Research Institute of Pharmacology, Moscow, Russia. zabrodinavv@gmail.com.
authors: V V
authors: VV
authors: Zabrodina
authors: V. V. Zakusov Research Institute of Pharmacology, Moscow, Russia.
authors: O V
authors: OV
authors: Shreder
authors: V. V. Zakusov Research Institute of Pharmacology, Moscow, Russia.
authors: E D
authors: ED
authors: Shreder
authors: V. V. Zakusov Research Institute of Pharmacology, Moscow, Russia.
authors: A D
authors: AD
authors: Durnev
mesh_terms: D000818:Animals; D001562:Benzimidazoles / Q000008:administration & dosage / Q000627:therapeutic use*; D001622:Betaine / Q000008:administration & dosage / Q000627:therapeutic use*; D003071:Cognition / Q000187:drug effects; D003072:Cognition Disorders / Q000188:drug therapy* / Q000209:etiology; D020552:Comet Assay; D004249:DNA Damage / Q000187:drug effects* / Q000235:genetics; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy* / Q000235:genetics; D005260:Female; D008297:Male; D009025:Morpholines / Q000008:administration & dosage / Q000627:therapeutic use*; D011247:Pregnancy; D051381:Rats
chemical_list: C410924:2-((2-morpholino)ethylthio)-5-ethoxybenzimidazole; D001562:Benzimidazoles; D009025:Morpholines; D001622:Betaine
keywords: DNA comet assay; afobazole; betaine; diabetes; streptozotocin