title: Evaluation of Substituted 1,2,3-Dithiazoles as Inhibitors of the Feline Immunodeficiency Virus (FIV) Nucleocapsid Protein via a Proposed Zinc Ejection Mechanism.
abstract: A diverse library of 5-thieno-, 5-oxo-, and 5-imino-1,2,3-dithiazole derivatives was synthesized and evaluated for efficacy against the feline immunodeficiency virus (FIV) as a model for HIV in cells. Several diverse compounds from this series displayed nanomolar activity and low toxicity, representing a potential new class of compounds for the treatment of FIV and HIV.
authors: School of Pharmacy, Faculty of Life Sciences, University College London, London, WC1N 1AX, UK.|Clinical Laboratory & Center for Clinical Studies, Vetsuisse Faculty, University of Zurich, 8057, Zurich, Switzerland.
authors: Christopher R M
authors: 0000-0001-5871-3458
authors: CR
authors: Asquith
authors: Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Moscow, 119991, Russian Federation.|Nanotechnology Education and Research Center, South Ural State, University, Lenina Ave. 76, Chelyabinsk, 454080, Russian Federation.
authors: Lidia S
authors: LS
authors: Konstantinova
authors: School of Pharmacy, Faculty of Health Sciences, University of Eastern, Finland, Kuopio, 70211, Finland.
authors: Tuomo
authors: T
authors: Laitinen
authors: Clinical Laboratory & Center for Clinical Studies, Vetsuisse Faculty, University of Zurich, 8057, Zurich, Switzerland.
authors: Marina L
authors: 0000-0002-3609-2416
authors: ML
authors: Meli
authors: School of Pharmacy, Faculty of Health Sciences, University of Eastern, Finland, Kuopio, 70211, Finland.
authors: Antti
authors: A
authors: Poso
authors: Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Moscow, 119991, Russian Federation.|Nanotechnology Education and Research Center, South Ural State, University, Lenina Ave. 76, Chelyabinsk, 454080, Russian Federation.
authors: Oleg A
authors: 0000-0001-6609-4087
authors: OA
authors: Rakitin
authors: Clinical Laboratory & Center for Clinical Studies, Vetsuisse Faculty, University of Zurich, 8057, Zurich, Switzerland.
authors: Regina
authors: 0000-0001-9750-4296
authors: R
authors: Hofmann-Lehmann
authors: School of Pharmacy, Faculty of Life Sciences, University College London, London, WC1N 1AX, UK. s.hilton@ucl.ac.uk.
authors: Stephen T
authors: 0000-0001-8782-4499
authors: ST
authors: Hilton
mesh_terms: D000998:Antiviral Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D006801:Humans; D016089:Immunodeficiency Virus, Feline / Q000737:chemistry / Q000187:drug effects*; D008958:Models, Molecular; D015394:Molecular Structure; D019590:Nucleocapsid Proteins / Q000037:antagonists & inhibitors* / Q000737:chemistry / Q000378:metabolism; D013329:Structure-Activity Relationship; D013844:Thiazoles / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D015032:Zinc / Q000378:metabolism*
chemical_list: D000998:Antiviral Agents; D019590:Nucleocapsid Proteins; D013844:Thiazoles; D015032:Zinc
keywords: FIV; HIV-1; homology models; nucleocapsid protein; zinc abstraction; zinc ejection