title: Pd-Catalyzed C-S Activation/Isocyanide Insertion/Hydrogenation Enables a Selective Aerobic Oxidation/Cyclization.
abstract: Unique imidoylation of thioorganics with isocyanides endows an unprecedented aerobic oxidation process. Catalyzed by Pd(Ph3P)2Cl2 in the presence of Ph3SiH under N2 then upon exposure to air, a wide range of α-acyl ketene dithioacetals react with isocyanides to afford 5-hydroxy-α,β-unsaturated γ-lactams via a C-S bond activation, isocyanide migratory insertion, hydrogenation, selective aerobic oxidation, and intramolecular nucleophilic addition sequence.
authors: Jilin Province Key Laboratory of Organic Functional Molecular Design & Synthesis, Faculty of Chemistry, Northeast Normal University , Changchun 130024, China.
authors: Jian
authors: J
authors: Chang
authors: Jilin Province Key Laboratory of Organic Functional Molecular Design & Synthesis, Faculty of Chemistry, Northeast Normal University , Changchun 130024, China.
authors: Bangyu
authors: B
authors: Liu
authors: Jilin Province Key Laboratory of Organic Functional Molecular Design & Synthesis, Faculty of Chemistry, Northeast Normal University , Changchun 130024, China.
authors: Yang
authors: Y
authors: Yang
authors: Jilin Province Key Laboratory of Organic Functional Molecular Design & Synthesis, Faculty of Chemistry, Northeast Normal University , Changchun 130024, China.|State Key Laboratory of Fine Chemicals, Dalian University of Technology , Dalian 116024, China.
authors: Mang
authors: M
authors: Wang