title: Stressed-Out HSCs Turn Up p38α and Purine to Proliferate.
abstract: Changes in cellular metabolism drive hematopoietic stem cell (HSC) behavior during homeostasis, although whether they control HSC behavior during stress conditions is unclear. In this issue of Cell Stem Cell, Karigane et al. (2016) identify a p38α-dependent pathway that alters purine metabolism in HSCs during stress hematopoiesis, promoting hematopoietic recovery.
authors: Hematopoietic Stem Cells and Stress Group, German Cancer Research Center-DKFZ, 69121 Heidelberg, Germany; Heidelberg Institute for Stem Cell Technology and Experimental Medicine-HI-STEM, Im Neuenheimerfeld 280, 69120 Heidelberg, Germany. Electronic address: m.essers@dkfz.de.
authors: Marieke A G
authors: MAG
authors: Essers
mesh_terms: D006410:Hematopoiesis; D006412:Hematopoietic Stem Cells; D006706:Homeostasis; D011687:Purines
chemical_list: D011687:Purines