title: Diffusion kurtosis imaging study on temporal lobe after nasopharyngeal carcinoma radiotherapy.
abstract: Diffusion kurtosis imaging (DKI) is a MRI technique which can measure alterations in the diffusion of water molecules to reflect tissue changes in both white and grey matter. This study evaluated the potential of DKI for the early diagnosis of radiation-induced temporal lobe changes in the grey and white matter of the temporal lobe in patients with nasopharyngeal carcinoma (NPC).
  
  
  
  Sixty patients with NPC who had normal MRI brain scans were enrolled and underwent DKI at 1 week (n=20), 6 months (n=20) or 1 year (n=20) after radiotherapy; 20 normal control individuals were also evaluated. Nonlinear fitting routines and equations were used to calculate mean diffusion (MD) and mean kurtosis (MK) and fractional anisotropy (FA). Analysis of variance was used to compare the MK/MD/FA values of white and grey matter between groups.
  
  
  
  Compared to the normal control group, grey and white matter MK values were significantly higher at 1 week after radiotherapy and significantly lower at 6 months and 1 year after radiotherapy in patients with NPC, whereas the grey and white matter MD values were significantly lower at 1 week after radiotherapy and returned to normal by 6 months and 1 year after radiotherapy.
  
  
  
  DKI can be used to detect radiotherapy-induced changes in both the white and grey matter of temporal lobe in patients with NPC. MK and MD values may represent reliable indicators for the early diagnosis of radiation-induced temporal lobe changes in NPC.
authors: Institute of Diagnostic and Interventional Radiology, The Sixth Affiliated People's Hospital, Shanghai Jiao Tong University, No. 600, Yi Shan Road, Shanghai 200233, China.
authors: Dan
authors: D
authors: Wang
authors: Institute of Diagnostic and Interventional Radiology, The Sixth Affiliated People's Hospital, Shanghai Jiao Tong University, No. 600, Yi Shan Road, Shanghai 200233, China. Electronic address: liyuehua312@163.com.
authors: Yue-Hua
authors: YH
authors: Li
authors: Department of Radiotherapy, The Sixth Affiliated People's Hospital, Shanghai Jiao Tong University, No. 600, Yi Shan Road, Shanghai 200233, China.
authors: Jie
authors: J
authors: Fu
authors: Philips Research China, Philips Innovation Campus Shanghai, China.
authors: He
authors: H
authors: Wang
mesh_terms: D002277:Carcinoma / Q000000981:diagnostic imaging* / Q000473:pathology / Q000532:radiotherapy*; D038524:Diffusion Magnetic Resonance Imaging; D005260:Female; D066128:Gray Matter / Q000000981:diagnostic imaging / Q000473:pathology / Q000528:radiation effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D000077274:Nasopharyngeal Carcinoma; D009303:Nasopharyngeal Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology / Q000532:radiotherapy*; D013702:Temporal Lobe / Q000000981:diagnostic imaging* / Q000473:pathology / Q000528:radiation effects*; D066127:White Matter / Q000000981:diagnostic imaging / Q000378:metabolism / Q000528:radiation effects
keywords: Diffusion kurtosis imaging; Magnetic resonance imaging; Nasopharyngeal carcinoma; Radiotherapy changes