title: Positron emission tomography and nanotechnology: A dynamic duo for cancer theranostics.
abstract: Development of novel imaging probes for cancer diagnosis is critical for early disease detection and management. The past two decades have witnessed a surge in the development and evolution of radiolabeled nanoparticles as a new frontier in personalized cancer nanomedicine. The dynamic synergism of positron emission tomography (PET) and nanotechnology combines the sensitivity and quantitative nature of PET with the multifunctionality and tunability of nanomaterials, which can help overcome certain key challenges in the field. In this review, we discuss the recent advances in radionanomedicine, exemplifying the ability to tailor the physicochemical properties of nanomaterials to achieve optimal in vivo pharmacokinetics and targeted molecular imaging in living subjects. Innovations in development of facile and robust radiolabeling strategies and biomedical applications of such radionanoprobes in cancer theranostics are highlighted. Imminent issues in clinical translation of radiolabeled nanomaterials are also discussed, with emphasis on multidisciplinary efforts needed to quickly move these promising agents from bench to bedside.
authors: Materials Science Program, University of Wisconsin-Madison, Madison, WI 53705, USA.
authors: Shreya
authors: S
authors: Goel
authors: Department of Medical Physics, University of Wisconsin-Madison, Madison, WI 53705, USA.
authors: Christopher G
authors: CG
authors: England
authors: Department of Radiology, University of Wisconsin-Madison, Madison, WI 53792, USA. Electronic address: chenf@mskcc.org.
authors: Feng
authors: F
authors: Chen
authors: Materials Science Program, University of Wisconsin-Madison, Madison, WI 53705, USA; Department of Medical Physics, University of Wisconsin-Madison, Madison, WI 53705, USA; Department of Radiology, University of Wisconsin-Madison, Madison, WI 53792, USA; University of Wisconsin Carbone Cancer Center, Madison, WI 53792, USA. Electronic address: WCai@uwhealth.org.
authors: Weibo
authors: W
authors: Cai
mesh_terms: D000818:Animals; D006801:Humans; D053758:Nanoparticles / Q000627:therapeutic use*; D009369:Neoplasms / Q000000981:diagnostic imaging* / Q000188:drug therapy*; D049268:Positron-Emission Tomography; D000068936:Theranostic Nanomedicine
keywords: Cancer theranostics; Nanotechnology; Positron emission tomography; Radiochemistry; Radiolabeled nanoparticles