title: Successful Treatment of Relapsing Bowen's Disease with Ingenol Mebutate: The Use of Dermoscopy to Monitor the Therapeutic Response.
abstract: Ingenol mebutate (IM) has recently been approved for the topical treatment of actinic keratoses. It appears to have a dual mechanism of action: rapid necrosis after gel application and a subsequent immune-mediated response, which targets any residual dysplastic epidermal cells. We report the successful treatment of a woman, who had been relapsing into Bowen's disease (BD) on her right forefinger for 8 years. During her clinical history, she had received an allogeneic, HLA-identical stem cell transplant for myeloproliferative syndrome with a JAK2V617F mutation and lobectomy of the pulmonary right lower lobe for adenocarcinoma. We used dermoscopy to monitor the therapeutic response of BD. We discuss IM gel as a possible therapeutic option for BD.
authors: Department of Dermatology, Ospedale Regionale Bellinzona e Valli, Bellinzona, Switzerland.
authors: Carlo
authors: C
authors: Mainetti
authors: Caroline
authors: C
authors: Guillod
authors: Sandra
authors: S
authors: Leoni-Parvex
mesh_terms: D000230:Adenocarcinoma / Q000601:surgery; D000279:Administration, Cutaneous; D000368:Aged; D000970:Antineoplastic Agents / Q000008:administration & dosage*; D001913:Bowen's Disease / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy*; D046169:Dermoscopy; D004224:Diterpenes / Q000008:administration & dosage*; D005260:Female; D005385:Fingers; D005782:Gels; D006801:Humans; D008175:Lung Neoplasms / Q000150:complications / Q000601:surgery; D009196:Myeloproliferative Disorders / Q000150:complications / Q000235:genetics / Q000628:therapy; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis / Q000188:drug therapy*; D011013:Pneumonectomy; D012878:Skin Neoplasms / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy*; D033581:Stem Cell Transplantation
chemical_list: C486592:3-ingenyl angelate; D000970:Antineoplastic Agents; D004224:Diterpenes; D005782:Gels