title: Multifunctional PLGA/Parylene C Coating for Implant Materials: An Integral Approach for Biointerface Optimization.
abstract: Functionalizing implant surfaces is critical for improving their performance. An integrated approach was employed to develop a multifunctional implant coating based on oxygen plasma-modified parylene C and drug-loaded, biodegradable poly(dl-lactide-co-glycolide) (PLGA). The key functional attributes of the coating (i.e., anti-corrosion, biocompatible, anti-infection, and therapeutic) were thoroughly characterized at each fabrication step by spectroscopic, microscopic, and biologic methods and at different scales, ranging from molecular, through the nano- and microscales to the macroscopic scale. The chemistry of each layer was demonstrated separately, and their mutual affinity was shown to be indispensable for the development of versatile coatings for implant applications.
authors: Faculty of Chemistry, Jagiellonian University , Ingardena 3, 30-060 Krakow, Poland.
authors: M
authors: M
authors: Golda-Cepa
authors: Faculty of Chemistry, Jagiellonian University , Ingardena 3, 30-060 Krakow, Poland.
authors: A
authors: A
authors: Chorylek
authors: Faculty of Chemistry, Jagiellonian University , Ingardena 3, 30-060 Krakow, Poland.
authors: P
authors: P
authors: Chytrosz
authors: Department of Bacteriology, Microbial Ecology and Parasitology, Jagiellonian University Medical College , Czysta 18, 31-121 Krakow, Poland.
authors: M
authors: M
authors: Brzychczy-Wloch
authors: Centre of Polymer and Carbon Materials, Polish Academy of Sciences , Curie Skłodowskiej 34, 41-819 Zabrze, Poland.
authors: J
authors: J
authors: Jaworska
authors: Centre of Polymer and Carbon Materials, Polish Academy of Sciences , Curie Skłodowskiej 34, 41-819 Zabrze, Poland.
authors: J
authors: J
authors: Kasperczyk
authors: Department of Fiber and Polymer Technology, KTH Royal Institute of Technology , SE-100 44 Stockholm, Sweden.
authors: M
authors: M
authors: Hakkarainen
authors: Department of Chemical Engineering and Technology, KTH Royal Institute of Technology , SE-100 44 Stockholm, Sweden.
authors: K
authors: K
authors: Engvall
authors: Faculty of Chemistry, Jagiellonian University , Ingardena 3, 30-060 Krakow, Poland.
authors: A
authors: A
authors: Kotarba
mesh_terms: D020099:Coated Materials, Biocompatible; D019344:Lactic Acid / Q000737:chemistry*; D011100:Polyglycolic Acid / Q000737:chemistry*; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011108:Polymers; D014992:Xylenes
chemical_list: D020099:Coated Materials, Biocompatible; D011108:Polymers; D014992:Xylenes; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; C011055:parylene; D011100:Polyglycolic Acid; D019344:Lactic Acid
keywords: MG-63; PLGA; biointerface; coating; controlled drug elution; implant; oxygen plasma; parylene C