title: Diboron-Assisted Palladium-Catalyzed Transfer Hydrogenation of N-Heteroaromatics with Water as Hydrogen Donor and Solvent.
abstract: A Pd-catalyzed transfer hydrogenation of various N-heteroaromatic compounds with B2pin2 as a mediator and environmentally benign water as both solvent and hydrogen donor has been disclosed. This reaction proceeded under ambient temperature with a broad range of N-heteroaromatic compounds among which imidazo[1,2-a]pyridine derivatives were for the first time selectively reduced to 5,6,7,8-tetrahydroimidazo[1,2-a]pyridines, which are the core structural motifs of an inhibitor of human O-GlcNAcase. Mechanistic studies suggested that the new protons in products are from water and Pd-H might be the key intermediate with B2pin2 as the H2O activator.
authors: Institute of Next Generation Matter Transformation, College of Chemical Engineering at Huaqiao University , 668 Jimei Boulevard, Xiamen, Fujian 361021, P. R. China.
authors: Qingqing
authors: Q
authors: Xuan
authors: Institute of Next Generation Matter Transformation, College of Chemical Engineering at Huaqiao University , 668 Jimei Boulevard, Xiamen, Fujian 361021, P. R. China.|National Laboratory for Molecular Sciences, Institute of Chemistry, CAS , Beijing 100190, P. R. China.
authors: Qiuling
authors: Q
authors: Song