title: Cerebral Blood Flow Autoregulation and Dysautoregulation.
abstract: This article provides a review of cerebral autoregulation, particularly as it relates to the clinician scientist experienced in neuroscience in anesthesia and critical care. Topics covered are biological mechanisms; methods used for assessment of autoregulation; effects of anesthetics; role in control of cerebral hemodynamics in health and disease; and emerging areas, such as role of age and sex in contribution to dysautoregulation. Emphasis is placed on bidirectional translational research wherein the clinical informs the study design of basic science studies, which, in turn, informs the clinical to result in development of improved therapies for treatment of central nervous system conditions.
authors: Department of Anesthesiology and Critical Care, University of Pennsylvania, 3620 Hamilton Walk, JM3, Philadelphia, PA l9l04, USA; Department of Pharmacology, University of Pennsylvania, Philadelphia, PA l9l04, USA. Electronic address: armsteaw@uphs.upenn.edu.
authors: William M
authors: WM
authors: Armstead
mesh_terms: D000777:Anesthetics / Q000494:pharmacology; D000818:Animals; D000070642:Brain Injuries, Traumatic / Q000503:physiopathology; D002560:Cerebrovascular Circulation / Q000502:physiology*; D048049:Extracellular Signal-Regulated MAP Kinases / Q000502:physiology; D006706:Homeostasis / Q000187:drug effects / Q000502:physiology*; D006801:Humans; D007427:Intracranial Pressure
chemical_list: D000777:Anesthetics; D048049:Extracellular Signal-Regulated MAP Kinases
keywords: Anesthetics; Cerebral autoregulation; Cerebral blood flow; Traumatic brain injury