title: Quantitative assessment of CD44 genetic variants and cancer susceptibility in Asians: a meta-analysis.
abstract: CD44 is a well-established cancer stem cell marker playing a crucial role in tumor metastasis, recurrence and chemo-resistance. Genetic variants of CD44 have been shown to be associated with susceptibility to various cancers; however, the results are confounding. Hence, we performed a meta-analysis to clarify these associations more accurately. Overall, rs13347 (T vs. C: OR=1.30, p=<0.004, pcorr=0.032; CT vs. CC: OR=1.29, p=0.015, pcorr=0.047; TT vs. CC: OR=1.77, p=<0.000, pcorr=0.018; CT+TT vs. CC: OR=1.34, p=<0.009, pcorr=0.041) and rs187115 (GG vs. AA: OR=2.34, p=<0.000, pcorr=0.025; AG vs. AA: OR=1.59, p=<0.000, pcorr=0.038; G vs. A allele OR=1.56, p=0.000, pcorr=0.05; AG+GG vs. AA: OR=1.63, p=<0.000, pcorr=0.013) polymorphisms were found to significantly increase the cancer risk in Asians. On the other hand, rs11821102 was found to confer low risk (A vs. G: OR=0.87, p=<0.027, pcorr=0.04; AG vs. GG: OR=0.85, p=<0.017, pcorr=0.01; AG+AA vs. GG: OR=0.86, p=<0.020, pcorr=0.02). Based on our analysis, we suggest significant role of CD44 variants (rs13347, rs187115 and rs11821102) in modulating individual's cancer susceptibility in Asians. Therefore, these variants may be used as predictive genetic biomarkers for cancer predisposition in Asian populations. However, more comprehensive studies involving other cancers and/or populations, haplotypes, gene-gene and gene-environment interactions are necessary to delineate the role of these variants in conferring cancer risk.
authors: Department of Biosciences, Integral University, Lucknow, UP, India.|Stephenson Cancer Center (SCC), University of Oklahoma Health Sciences Center (OUHSC), Oklahoma City, OK, USA.
authors: Vishal
authors: V
authors: Chandra
authors: School of Biotechnology, Yeungnam University, Gyeongsan, Gyeongbuk, Korea.
authors: Yun-Mi
authors: YM
authors: Lee
authors: Sanjay Gandhi Post Graduate Institute of Medical Sciences (SGPGIMS), Lucknow, India.
authors: Usha
authors: U
authors: Gupta
authors: Sanjay Gandhi Post Graduate Institute of Medical Sciences (SGPGIMS), Lucknow, India.
authors: Balraj
authors: B
authors: Mittal
authors: School of Biotechnology, Yeungnam University, Gyeongsan, Gyeongbuk, Korea.
authors: Jong Joo
authors: JJ
authors: Kim
authors: School of Biotechnology, Yeungnam University, Gyeongsan, Gyeongbuk, Korea.
authors: Rajani
authors: R
authors: Rai
mesh_terms: D044466:Asian People / Q000235:genetics; D020022:Genetic Predisposition to Disease; D014644:Genetic Variation; D006801:Humans; D018960:Hyaluronan Receptors / Q000235:genetics*; D009369:Neoplasms / Q000235:genetics*; D011110:Polymorphism, Genetic; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors
chemical_list: C497483:CD44 protein, human; D018960:Hyaluronan Receptors
keywords: CD44; cancer; meta-analysis; single nucleotide polymorphisms (SNP); susceptibility