title: Catalyst-Free Chemoselective Synthesis of 3,4-Dihydroquinazoline-2-thiones and 2-Imino[1,3]benzothiazines.
abstract: A solvent-controlled catalyst-free chemoselective reaction was developed. Both 3,4-dihydroquinazoline-2-thiones and 2-imino[1,3]benzothiazines could be efficiently constructed by the reaction of 2-amino chalcones with isothiocyanates via two different chemoselective reactions depending on the solvents. The reaction was modulated by the solvents to proceed via either aza-Michael addition or thia-Michael addition as the major reaction with excellent yields.
authors: State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University , Lanzhou 730000, P. R. China.
authors: Ting
authors: T
authors: Xie
authors: State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University , Lanzhou 730000, P. R. China.
authors: Yu
authors: Y
authors: Xiao
authors: School of Pharmaceutical Engineering & Life Science, Changzhou University , Changzhou 213164, P. R. China.
authors: Shuai
authors: S
authors: Zhao
authors: State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University , Lanzhou 730000, P. R. China.
authors: Xiu-Qin
authors: XQ
authors: Hu
authors: State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University , Lanzhou 730000, P. R. China.
authors: Peng-Fei
authors: PF
authors: Xu