title: Insulin Autoimmune Syndrome Accompanied by Multiple Myeloma.
abstract: In 1981, a 48-year old man was diagnosed with insulin autoimmune syndrome. In 2005, he experienced a substantial increase in his monoclonal insulin antibody levels; in 2006 and 2007, serum monoclonal gammopathy and an 11% marrow plasmacyte ratio were confirmed. In 2012, asymptomatic multiple myeloma was diagnosed based on an increased γ-globulin fraction and serum M-protein (IgG) levels. The insulin antibody binding rate was 75.4% in 2005 and 78.8% in 2012. In 2012, he was hospitalized for ileus and died. Autopsy identified multiple myeloma and no endocrinological tumors in the pancreas.
authors: Meinan Hospital, Japan.
authors: Harumi
authors: H
authors: Ito
authors: Takafumi
authors: T
authors: Miyake
authors: Kazuo
authors: K
authors: Nakashima
authors: Yuji
authors: Y
authors: Ito
authors: Chisato
authors: C
authors: Tanahashi
authors: Yasuko
authors: Y
authors: Uchigata
mesh_terms: D001327:Autoimmune Diseases / Q000150:complications* / Q000276:immunology; D003920:Diabetes Mellitus / Q000276:immunology*; D017809:Fatal Outcome; D006801:Humans; D007330:Insulin Antibodies / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000150:complications* / Q000276:immunology; D009194:Myeloma Proteins
chemical_list: D007330:Insulin Antibodies; D009194:Myeloma Proteins; C085016:multiple myeloma M-proteins