title: Pregnancy outcomes in patients with severe pulmonary hypertension and Eisenmenger syndrome treated with sildenafil monotherapy.
abstract: Pregnancy outcomes in patients with pulmonary arterial hypertension have not been documented in our local setting. In our institution, access to therapies like nitric oxide, inhaled prostacyclin and iloprost is limited. We describe two such women given sildenafil monotherapy between April and May 2011. Both had an atrial septal defect complicated by Eisenmenger syndrome. Both survived - one after elective Caesarean section for malpresentation (breech) under general anaesthesia, the other after an assisted vaginal delivery. In addition to oral sildenafil, both received oxygen supplementation. To date, there have been three reported cases of pulmonary arterial hypertension in pregnancy treated with sildenafil in combination with another drug. Our two cases demonstrate that treatment for pulmonary arterial hypertension using sildenafil as monotherapy may allow stabilization of the maternal condition and improve clinical outcomes for both mother and baby. However, pregnancy is still discouraged in women with pulmonary arterial hypertension.
authors: Department of Internal Medicine, Las Pinas Doctors Hospital, Manila, Philippines.
authors: Reinalyn S
authors: RS
authors: Cartago
authors: Department of Internal Medicine Section Of Adult Cardiology, Philippine General Hospital, Manila, Philippines.
authors: Pichy Ann
authors: PA
authors: Alan
authors: Department of Internal Medicine Adult Pulmonary Medicine, Philippine General Hospital, Manila, Philippines.
authors: Jubert
authors: J
authors: Benedicto
keywords: High-risk pregnancy; complications