title: Tranexamic Acid in Anesthetic Management of Surgical Procedures.
abstract: Blood loss during surgical procedures poses a grave risk to the patient, but transfusion is costly and associated with adverse outcomes. Antifibrinolytics, however, offer an economical and effective means of decreasing blood loss associated with surgical procedures. Tranexamic acid (TXA) is an antifibrinolytic that blocks lysine-binding sites of fibrinogen and fibrin, preventing the breakdown of existing clots. This journal course reviews extensive research demonstrating that antifibrinolytics such as TXA decrease blood loss and in some studies reduce allogeneic transfusion requirements. In addition, this journal course addresses concerns that use of antifibrinolytics increases embolic events, reviews research that demonstrates TXA does not increase the incidence of vascular occlusive events, and describes methods of TXA use in cardiac and orthopedic surgical procedures, neurosurgery, and obstetrics. The Certified Registered Nurse Anesthetist should consider the possibility, on a case-by-case basis, of using TXA in surgical procedures to reduce blood loss with minimal adverse effects.
authors: Jessica
authors: J
authors: Mayeux
authors: Kathy
authors: K
authors: Alwon
authors: Shawn
authors: S
authors: Collins
authors: Ian
authors: I
authors: Hewer
mesh_terms: D000933:Antifibrinolytic Agents / Q000008:administration & dosage* / Q000009:adverse effects; D016063:Blood Loss, Surgical / Q000451:nursing* / Q000517:prevention & control*; D001803:Blood Transfusion / Q000451:nursing; D006348:Cardiac Surgical Procedures / Q000451:nursing; D000075202:Contraindications; D006801:Humans; D007318:Inservice Training; D009719:Nurse Anesthetists / Q000193:education*; D019637:Orthopedic Procedures / Q000451:nursing; D014148:Tranexamic Acid / Q000008:administration & dosage* / Q000009:adverse effects
chemical_list: D000933:Antifibrinolytic Agents; D014148:Tranexamic Acid