title: Chromatin programming by developmentally regulated transcription factors: lessons from the study of haematopoietic stem cell specification and differentiation.
abstract: Although the body plan of individuals is encoded in their genomes, each cell type expresses a different gene expression programme and therefore has access to only a subset of this information. Alterations to gene expression programmes are the underlying basis for the differentiation of multiple cell types and are driven by tissue-specific transcription factors (TFs) that interact with the epigenetic regulatory machinery to programme the chromatin landscape into transcriptionally active and inactive states. The haematopoietic system has long served as a paradigm for studying the molecular principles that regulate gene expression in development. In this review article, we summarize the current knowledge on the mechanism of action of TFs regulating haematopoietic stem cell specification and differentiation, and place this information into the context of general principles governing development.
authors: Institute of Cancer and Genomic Sciences, College of Medicine and Dentistry, University of Birmingham, UK.
authors: Nadine
authors: N
authors: Obier
authors: Institute of Cancer and Genomic Sciences, College of Medicine and Dentistry, University of Birmingham, UK.
authors: Constanze
authors: C
authors: Bonifer
mesh_terms: D002454:Cell Differentiation / Q000235:genetics*; D019070:Cell Lineage / Q000235:genetics; D002843:Chromatin / Q000235:genetics*; D044127:Epigenesis, Genetic; D018507:Gene Expression Regulation, Developmental; D006412:Hematopoietic Stem Cells; D006801:Humans; D014157:Transcription Factors / Q000235:genetics*
chemical_list: D002843:Chromatin; D014157:Transcription Factors
keywords: chromatin; haematopoietic specification; transcription factors