title: Non-immune mediated thrombocytopenia caused by thromboprophylaxis for the perioperative care of urological surgery: A case report and review of the literature.
abstract: BACKGROUND
  Heparin-induced thrombocytopenia (HIT) is a rare but serious condition due to heparin use for treating thromboprophylaxis, regardless of the dosage. Here, we present a case of non-immune thrombocytopenia caused by thromboprophylaxis for urological surgery, which is sometimes difficult to discriminate from immune-mediated thrombocytopenia.
  
  
  METHODS
  A 55-year-old man with renal cancer underwent portless endoscopic radical nephrectomy through a single small incision and was subsequently administered unfractionated heparin as well as mechanical devices to prevent venous thromboembolism. On postoperative day 2, a subcutaneous hemorrhage developed around the surgical site and the lower abdomen, and the platelet count simultaneously decreased to 50% of the baseline value. We suspected HIT and immediately conducted the 4Ts score examination. The 4Ts score was 3 points (low probability), and the result of the platelet factor 4-heparin complex antibody assay was negative. The patient was diagnosed with non-immune mediated thrombocytopenia. We took precaution by discontinuing heparin, which fortunately did not result in any adverse effects, and this led to platelet count normalization.
  
  
  CONCLUSIONS
  Due to the rarity of HIT, it is difficult to distinguish HIT from non-immune mediated thrombocytopenia.
  
  
  CONCLUSIONS
  This article emphasizes that early and accurate diagnosis of postoperative thrombocytopenia is important for accurate therapy. Hence, all surgeons should know that the HIT diagnosis is based on clinical and serologic findings.
authors: Department of Urology, Jikei University School of Medicine, Tokyo, Japan; Department of Urology, Atsugi City Hospital, Kanagawa, Japan. Electronic address: hataken1@jikei.ac.jp.
authors: Kenichi
authors: K
authors: Hata
authors: Department of Urology, Jikei University School of Medicine, Tokyo, Japan.
authors: Takahiro
authors: T
authors: Kimura
authors: Department of Urology, Atsugi City Hospital, Kanagawa, Japan.
authors: Gen
authors: G
authors: Ishii
authors: Department of Urology, Atsugi City Hospital, Kanagawa, Japan.
authors: Masayasu
authors: M
authors: Suzuki
authors: Department of Urology, Jikei University School of Medicine, Tokyo, Japan.
authors: Shin
authors: S
authors: Egawa
keywords: Case report; Heparin-induced thrombocytopenia; Thromboprophylaxis; Urologic surgery