title: The antibiotics of choice for the treatment of melioidosis in Indian set up.
abstract: Therapeutic options for the treatment of melioidosis caused by Burkholderia pseudomallei are limited due to the inherent resistance conferred by this pathogen to various groups of antibiotics. Witnessing an increase in the number of microbiological culture-confirmed cases of melioidosis at our settings in the past few years, we undertook this study to estimate the minimum inhibitory concentrations of clinical isolates of B. pseudomallei against the four commonly employed antimicrobial agents in the patient management at our settings, namely, ceftazidime, meropenem, trimethoprim-sulfamethoxazole and doxycycline. All isolates were susceptible to the antibiotics tested, except for one isolate which showed resistance to doxycycline (minimum inhibitory concentration [MIC]: 32 μg/ml). MIC50 and 90 for all the four antibiotics were estimated. From this study, we conclude that the clinical isolates of B. pseudomallei from the southern part of India are well susceptible to the commonly employed antimicrobial agents for therapy.
authors: Department of Microbiology, Kasturba Medical College, Manipal University, Manipal, Karnataka, India.
authors: T
authors: T
authors: Shaw
authors: Directorate of Research, Manipal University, Manipal, Karnataka, India.
authors: C
authors: C
authors: Tellapragada
authors: Department of Microbiology, Kasturba Medical College, Manipal University, Manipal, Karnataka, India.
authors: V K
authors: VK
authors: Eshwara
authors: Department of Community Medicine, Kasturba Medical College, Manipal University, Manipal, Karnataka, India.
authors: H V
authors: HV
authors: Bhat
authors: Department of Microbiology, Kasturba Medical College, Manipal University, Manipal, Karnataka, India.
authors: C
authors: C
authors: Mukhopadhyay
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology* / Q000627:therapeutic use; D016957:Burkholderia pseudomallei / Q000187:drug effects* / Q000302:isolation & purification; D006801:Humans; D007194:India; D008554:Melioidosis / Q000188:drug therapy / Q000382:microbiology*; D008826:Microbial Sensitivity Tests
chemical_list: D000900:Anti-Bacterial Agents