title: Establishing a Robust Molecular Taxonomy for Diffuse Gliomas of Adulthood.
abstract: The comprehensive molecular profiling of cancer has dramatically altered conceptions of numerous tumor types, particularly with regard to their fundamental classification. In the case of primary brain tumors, the widespread use of disease-defining biomarker sets is profoundly reshaping existing diagnostic entities that had been designated solely by histopathological criteria for decades. This review describes recent progress for diffusely infiltrating gliomas of adulthood, the most common primary brain tumor variants. More specifically, it details how routine incorporation of a handful of highly prevalent molecular alterations robustly designates refined subclasses of glioma that transcend conventional histopathological designations.
authors: Department of Pathology, Memorial Sloan-Kettering Cancer Center, 408 East 69th Street (Z564), New York, NY 10065, USA. Electronic address: husej@mskcc.org.
authors: Jason T
authors: JT
authors: Huse
mesh_terms: D014408:Biomarkers, Tumor / Q000235:genetics; D001932:Brain Neoplasms / Q000235:genetics / Q000473:pathology; D002872:Chromosome Deletion; D002878:Chromosomes, Human, Pair 1 / Q000235:genetics; D002888:Chromosomes, Human, Pair 19 / Q000235:genetics; D004265:DNA Helicases / Q000235:genetics; D005909:Glioblastoma / Q000235:genetics* / Q000473:pathology*; D005910:Glioma / Q000235:genetics* / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D017404:In Situ Hybridization, Fluorescence; D007521:Isocitrate Dehydrogenase / Q000235:genetics; D009154:Mutation / Q000235:genetics; D009687:Nuclear Proteins / Q000235:genetics; D011379:Prognosis; D011401:Promoter Regions, Genetic; D019098:Telomerase / Q000235:genetics; D000075924:X-linked Nuclear Protein
chemical_list: D014408:Biomarkers, Tumor; D009687:Nuclear Proteins; D007521:Isocitrate Dehydrogenase; C543588:IDH1 protein, human; C509186:TERT protein, human; D019098:Telomerase; D004265:DNA Helicases; C092332:ATRX protein, human; D000075924:X-linked Nuclear Protein
keywords: 1p/19q codeletion; ATRX; Genomics; Glioblastoma; Glioma; IDH1; TERT