title: The Temporal Signature of Memories: Identification of a General Mechanism for Dynamic Memory Replay in Humans.
abstract: Reinstatement of dynamic memories requires the replay of neural patterns that unfold over time in a similar manner as during perception. However, little is known about the mechanisms that guide such a temporally structured replay in humans, because previous studies used either unsuitable methods or paradigms to address this question. Here, we overcome these limitations by developing a new analysis method to detect the replay of temporal patterns in a paradigm that requires participants to mentally replay short sound or video clips. We show that memory reinstatement is accompanied by a decrease of low-frequency (8 Hz) power, which carries a temporal phase signature of the replayed stimulus. These replay effects were evident in the visual as well as in the auditory domain and were localized to sensory-specific regions. These results suggest low-frequency phase to be a domain-general mechanism that orchestrates dynamic memory replay in humans.
authors: School of Psychology, University of Birmingham, Birmingham, United Kingdom.
authors: Sebastian
authors: S
authors: Michelmann
authors: School of Psychology, University of Birmingham, Birmingham, United Kingdom.|School of Computing, University of Kent, Canterbury, United Kingdom.
authors: Howard
authors: H
authors: Bowman
authors: School of Psychology, University of Birmingham, Birmingham, United Kingdom.
authors: Simon
authors: S
authors: Hanslmayr
mesh_terms: D000161:Acoustic Stimulation; D000328:Adult; D000465:Algorithms; D001307:Auditory Perception / Q000502:physiology*; D001921:Brain / Q000502:physiology*; D004569:Electroencephalography; D005260:Female; D006801:Humans; D008297:Male; D008568:Memory / Q000502:physiology*; D008959:Models, Neurological; D010775:Photic Stimulation; D011597:Psychomotor Performance / Q000502:physiology*; D014796:Visual Perception / Q000502:physiology*; D055815:Young Adult