title: Guidelines to PET measurements of the target occupancy in the brain for drug development.
abstract: This guideline summarizes the current view of the European Association of Nuclear Medicine Drug Development Committee. The purpose of this guideline is to guarantee a high standard of PET studies that are aimed at measuring target occupancy in the brain within the framework of development programs of drugs that act within the central nervous system (CNS drugs). This guideline is intended to present information specifically adapted to European practice. The information provided should be applied within the context of local conditions and regulations.
authors: Department of Clinical Neuroscience, Centre for Psychiatric Research, Karolinska Institutet, Stockholm, Sweden. Akihiro.Takano@ki.se.
authors: Akihiro
authors: http://orcid.org/0000-0002-3034-7721
authors: A
authors: Takano
authors: Department of Clinical Neuroscience, Centre for Psychiatric Research, Karolinska Institutet, Stockholm, Sweden.
authors: Andrea
authors: A
authors: Varrone
authors: Department of Clinical Neuroscience, Centre for Psychiatric Research, Karolinska Institutet, Stockholm, Sweden.
authors: Balázs
authors: B
authors: Gulyás
authors: CNR Istituto di Fisiologia Clinica, Pisa, Italy.
authors: Piero
authors: P
authors: Salvadori
authors: Department of Chemistry and Biology, Division of Imaging Sciences and Biomedical Engineering, Kings College London, London, UK.
authors: Antony
authors: A
authors: Gee
authors: Department of Radiology & Nuclear Medicine, VU University Medical Center, Amsterdam, The Netherlands.
authors: Albert
authors: A
authors: Windhorst
authors: Université François Rabelais de Tours, UMR Inserm U930, Tours, France.
authors: Johnny
authors: J
authors: Vercouillie
authors: Nuclear Medicine and Molecular Imaging, Department of Imaging and Pathology, KU Leuven, Leuven, Belgium.
authors: Guy
authors: G
authors: Bormans
authors: Department of Radiology & Nuclear Medicine, VU University Medical Center, Amsterdam, The Netherlands.
authors: Adriaan A
authors: AA
authors: Lammertsma
authors: Department of Clinical Neuroscience, Centre for Psychiatric Research, Karolinska Institutet, Stockholm, Sweden.
authors: Christer
authors: C
authors: Halldin
mesh_terms: D001921:Brain / Q000378:metabolism*; D002491:Central Nervous System Agents / Q000008:administration & dosage / Q000493:pharmacokinetics*; D015195:Drug Design; D016903:Drug Monitoring / Q000592:standards; D005062:European Union; D057054:Molecular Imaging / Q000592:standards*; D009419:Nerve Tissue Proteins / Q000378:metabolism*; D049268:Positron-Emission Tomography / Q000592:standards*; D017410:Practice Guidelines as Topic
chemical_list: D002491:Central Nervous System Agents; D009419:Nerve Tissue Proteins
keywords: Drug development; Positron emission tomography; Target occupancy