title: Quantification of global myocardial function by cine MRI deformable registration-based analysis: Comparison with MR feature tracking and speckle-tracking echocardiography.
abstract: OBJECTIVE
  To evaluate deformable registration algorithms (DRA)-based quantification of cine steady-state free-precession (SSFP) for myocardial strain assessment in comparison with feature-tracking (FT) and speckle-tracking echocardiography (STE).
  
  
  METHODS
  Data sets of 28 patients/10 volunteers, undergoing same-day 1.5T cardiac MRI and echocardiography were included. LV global longitudinal (GLS), circumferential (GCS) and radial (GRS) peak systolic strain were assessed on cine SSFP data using commercially available FT algorithms and prototype DRA-based algorithms. STE was applied as standard of reference for accuracy, precision and intra-/interobserver reproducibility testing.
  
  
  RESULTS
  DRA showed narrower limits of agreement compared to STE for GLS (-4.0 [-0.9,-7.9]) and GCS (-5.1 [1.1,-11.2]) than FT (3.2 [11.2,-4.9]; 3.8 [13.9,-6.3], respectively). While both DRA and FT demonstrated significant differences to STE for GLS and GCS (all p<0.001), only DRA correlated significantly to STE for GLS (r=0.47; p=0.006). However, good correlation was demonstrated between MR techniques (GLS:r=0.74; GCS:r=0.80; GRS:r=0.45, all p<0.05). Comparing DRA with FT, intra-/interobserver coefficient of variance was lower (1.6 %/3.2 % vs. 6.4 %/5.7 %) and intraclass-correlation coefficient was higher. DRA GCS and GRS data presented zero variability for repeated observations.
  
  
  CONCLUSIONS
  DRA is an automated method that allows myocardial deformation assessment with superior reproducibility compared to FT.
  
  
  CONCLUSIONS
  • Inverse deformable registration algorithms (DRA) allow myocardial strain analysis on cine MRI. • Inverse DRA demonstrated superior reproducibility compared to feature-tracking (FT) methods. • Cine MR DRA and FT analysis demonstrate differences to speckle-tracking echocardiography • DRA demonstrated better correlation with STE than FT for MR-derived global strain data.
authors: Department of Medical Imaging, University Health Network, Toronto, Ontario, Canada.
authors: Mariana M
authors: MM
authors: Lamacie
authors: Department of Medical Imaging, University Health Network, Toronto, Ontario, Canada.|Department of Medicine, Division of Cardiology, University of Toronto, Toronto, Ontario, Canada.
authors: Paaladinesh
authors: P
authors: Thavendiranathan
authors: Department of Medical Imaging, University Health Network, Toronto, Ontario, Canada.|Department of Medical Imaging, University of Toronto, Toronto, Ontario, Canada.
authors: Kate
authors: K
authors: Hanneman
authors: Siemens Healthcare, Erlangen, Germany.
authors: Andreas
authors: A
authors: Greiser
authors: Siemens Healthcare, Medical Imaging Technologies, Princeton, NJ, USA.
authors: Marie-Pierre
authors: MP
authors: Jolly
authors: Department of Medicine, Division of Cardiology, University of Toronto, Toronto, Ontario, Canada.
authors: Richard
authors: R
authors: Ward
authors: Department of Medical Imaging, University Health Network, Toronto, Ontario, Canada. Bernd.Wintersperger@uhn.ca.|Department of Medical Imaging, University of Toronto, Toronto, Ontario, Canada. Bernd.Wintersperger@uhn.ca.|Department of Medical Imaging, Toronto General Hospital, 1 PMB-273, 585 University Avenue, Toronto, Ontario, M5G 2N2, Canada. Bernd.Wintersperger@uhn.ca.
authors: Bernd J
authors: BJ
authors: Wintersperger
mesh_terms: D000328:Adult; D000465:Algorithms; D004452:Echocardiography / Q000379:methods*; D005260:Female; D006321:Heart / Q000000981:diagnostic imaging* / Q000502:physiology* / Q000503:physiopathology; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D019028:Magnetic Resonance Imaging, Cine / Q000379:methods*; D008297:Male; D015203:Reproducibility of Results
keywords: Cardiac cine SSFP MRI; Deformable registration algorithms; Feature-tracking; Myocardial strain; Speckle-tracking