title: Colletotrilactam A-D, novel lactams from Colletotrichum gloeosporioides GT-7, a fungal endophyte of Uncaria rhynchophylla.
abstract: Four novel lactams, colletotrilactam A-D (1-4), along with six known compounds (5-10) were isolated from the culture broth of Colletotrichum gloeosporioides GT-7, a fungal endophyte of Uncaria rhynchophylla. The structures of these compounds were elucidated by comprehensive NMR spectroscopy. Isolates were tested for monoamine oxidase (MAO) inhibitory activity and compound 9 showed potent MAO inhibitory activity with IC50 value of 8.93±0.34μg/mL, when the IC50 value of iproniazid as a standard was 1.80±0.5μg/mL.
authors: School of Life Science and Engineering, Lanzhou University of Technology, Lanzhou 730050, PR China; The Provincial Education Key Laboratory of Screening, Evaluation and Advanced Processing of Traditional Chinese Medicine and Tibetan Medicine, School of Life Science and Engineering, Lanzhou University of Technology, Lanzhou, 730050, PR China.
authors: Bo
authors: B
authors: Wei
authors: School of Life Science and Engineering, Lanzhou University of Technology, Lanzhou 730050, PR China. Electronic address: yangzhongduo@126.com.
authors: Zhong-Duo
authors: ZD
authors: Yang
authors: School of Life Science and Engineering, Lanzhou University of Technology, Lanzhou 730050, PR China.
authors: Xiao-Wei
authors: XW
authors: Chen
authors: Department of Chemistry, Lanzhou University, Lanzhou 730000, PR China.
authors: Shuang-Yan
authors: SY
authors: Zhou
authors: Institute of Plant Protection, Gansu Academy of Agricultural Sciences, Lanzhou 730070, China.
authors: Hai-Tao
authors: HT
authors: Yu
authors: School of Life Science and Engineering, Lanzhou University of Technology, Lanzhou 730050, PR China.
authors: Jing-Yun
authors: JY
authors: Sun
authors: Department of Chemistry, Lanzhou University, Lanzhou 730000, PR China. Electronic address: xjyao@lzu.edu.cn.
authors: Xiao-Jun
authors: XJ
authors: Yao
authors: School of Life Science and Engineering, Lanzhou University of Technology, Lanzhou 730050, PR China.
authors: Yong-Gang
authors: YG
authors: Wang
authors: School of Life Science and Engineering, Lanzhou University of Technology, Lanzhou 730050, PR China.
authors: Hong-Yan
authors: HY
authors: Xue
mesh_terms: D020231:Colletotrichum / Q000737:chemistry*; D060026:Endophytes / Q000737:chemistry; D007769:Lactams / Q000737:chemistry* / Q000302:isolation & purification; D015394:Molecular Structure; D008995:Monoamine Oxidase / Q000378:metabolism; D008996:Monoamine Oxidase Inhibitors / Q000737:chemistry* / Q000302:isolation & purification; D032070:Uncaria / Q000382:microbiology*
chemical_list: D007769:Lactams; D008996:Monoamine Oxidase Inhibitors; D008995:Monoamine Oxidase
keywords: Blumenol A (PubChem CID: 5280462); Colletotrichum gloeosporioides; Colletotrilactam; Hederagonic acid (PubChem CID: 12310388); Lactams; Mellein (PubChem CID: 28516); Monoamine oxidase inhibitors; Rubiaceae; Uncaria rhynchophylla; cis-4-Hydroxymellein (PubChem CID: 44445003)