title: Difference in glaucoma progression between the first and second eye after consecutive bilateral glaucoma surgery in patients with bilateral uveitic glaucoma.
abstract: OBJECTIVE
  To determine whether the second eyes (SE) of patients with bilateral uveitic glaucoma undergoing filtration surgery have more glaucomatous progression in terms of visual acuity, visual field (VF) and optic nerve changes compared to the first eyes (FE).
  
  
  METHODS
  This retrospective study analysed data of 60 eyes from 30 patients with bilateral uveitic glaucoma who had undergone glaucoma surgery in both eyes on separate occasions. Humphrey VF progression was assessed using the Progressor software.
  
  
  RESULTS
  The pre-operative IOP between the FE (43.1 ± 7.7 mmHg) and SE (40 ± 8.7 mmHg) was not statistically significant (p = 0.15). IOP reduction was greater in the FE (64 %) than SE (59.7 %) post-operatively, but the mean IOP at the final visit in the FE (12.3 ± 3.9 mmHg) and SE (14.5 ± 7 mmHg) was not statistically different (p = 0.2). There was no significant change in mean logMAR readings pre and post-operatively (0.45 ± 0.6 vs 0.37 ± 0.6, p = 0.4) or between the FE and SE. The number of SE with CDR > 0.7 increased by 23 % compared to the FE. From 23 available VFs, five SE (21.7 %) progressed at a median of five locations (range 1-11 points) with a mean local slope reduction of 1.74 ± 0.45 dB/year (range -2.39 to -1.26), whereas only one FE progressed. However, there was no significant difference between mean global rate of progression between the FE (-0.9 ± 1.6 dB/year) and SE (-0.76 ± 2.1 dB/year, p = 0.17) in the Humphrey VF.
  
  
  CONCLUSIONS
  In eyes with bilateral uveitic glaucoma requiring glaucoma surgery, the SEs had more progressed points on VF and glaucomatous disc progression compared to FEs at the final visit.
authors: UCL Institute of Ophthalmology, 11-43 Bath Street, London, EC1V 9EL, UK.|UCL Institute of Ophthalmology, Moorfields Eye Hospital, City Road, London, EC1V 2PD, UK.|Universiti Kebangsaan Malaysia, Jalan Yaacob Latiff, Cheras, 56000, Kuala Lumpur, Malaysia.
authors: Norshamsiah Md
authors: NM
authors: Din
authors: UCL Institute of Ophthalmology, 11-43 Bath Street, London, EC1V 9EL, UK.|UCL Institute of Ophthalmology, Moorfields Eye Hospital, City Road, London, EC1V 2PD, UK.
authors: Lazha
authors: L
authors: Talat
authors: UCL Institute of Ophthalmology, 11-43 Bath Street, London, EC1V 9EL, UK.|UCL Institute of Ophthalmology, Moorfields Eye Hospital, City Road, London, EC1V 2PD, UK.|Universiti Kebangsaan Malaysia, Jalan Yaacob Latiff, Cheras, 56000, Kuala Lumpur, Malaysia.
authors: Hazlita
authors: H
authors: Isa
authors: UCL Institute of Ophthalmology, 11-43 Bath Street, London, EC1V 9EL, UK.|UCL Institute of Ophthalmology, Moorfields Eye Hospital, City Road, London, EC1V 2PD, UK.
authors: Oren
authors: O
authors: Tomkins-Netzer
authors: UCL Institute of Ophthalmology, 11-43 Bath Street, London, EC1V 9EL, UK.|UCL Institute of Ophthalmology, Moorfields Eye Hospital, City Road, London, EC1V 2PD, UK.|NIHR Biomedical Research Centre for Ophthalmology, Moorfields Eye Hospital, London, UK.
authors: Keith
authors: K
authors: Barton
authors: UCL Institute of Ophthalmology, 11-43 Bath Street, London, EC1V 9EL, UK. s.lightman@ucl.ac.uk.|UCL Institute of Ophthalmology, Moorfields Eye Hospital, City Road, London, EC1V 2PD, UK. s.lightman@ucl.ac.uk.
authors: Sue
authors: S
authors: Lightman
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D018450:Disease Progression; D005260:Female; D018463:Filtering Surgery / Q000009:adverse effects*; D005500:Follow-Up Studies; D005901:Glaucoma / Q000150:complications / Q000503:physiopathology / Q000601:surgery*; D006801:Humans; D007429:Intraocular Pressure / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D009898:Optic Disk / Q000473:pathology; D009901:Optic Nerve Diseases / Q000175:diagnosis / Q000209:etiology; D012189:Retrospective Studies; D013997:Time Factors; D014605:Uveitis / Q000150:complications*; D014792:Visual Acuity; D014794:Visual Fields / Q000502:physiology*; D055815:Young Adult
keywords: Filtering surgery; Glaucoma progression; Progressor software; Uveitic glaucoma