title: In situ injection of phenylboronic acid based low molecular weight gels for efficient chemotherapy.
abstract: Injectable low molecular weight gels (LMWGs) based on the derivatives of phenylboronic acid were prepared and used as substrates for efficient in situ chemotherapy. The gelators as well as LMWGs were characterized by (1)H NMR, UV-vis, FTIR, MS and SEM. Anticancer drug doxorubicin hydrochloride (DOX) was encapsulated in the gels. The rheological properties and rapid recovery capability of both blank and drug-loaded gels were tested. The LMWGs were non-toxic to both 3T3 fibroblasts and 4T1 breast cancer cells. The gels were formed rapidly after injected in vivo. The in vivo anticancer activities of DOX-loaded LMWGs were investigated in breast cancer bearing mice. The intratumoral injection of DOX loaded LMWGs with dose of 30 mg/kg revealed that the gels could coat around the tumor tissues to release DOX sustainingly and maintain effective DOX concentration for chemotherapy. The systemic toxicity of DOX was reduced significantly with the in situ administration of LMWGs formulations. The injectable LMWGs exhibited excellent therapeutic efficacy and low side effects in local chemotherapy.
authors: College of Chemistry and Materials Engineering, Wenzhou University, Wenzhou, 325027, China.
authors: Wenxia
authors: W
authors: Gao
authors: National Engineering Research Center for Biomaterials, Sichuan University, Chengdu, 610064, China. Electronic address: liangyan072@foxmail.com.
authors: Yan
authors: Y
authors: Liang
authors: National Engineering Research Center for Biomaterials, Sichuan University, Chengdu, 610064, China.
authors: Xinyu
authors: X
authors: Peng
authors: College of Chemistry and Materials Engineering, Wenzhou University, Wenzhou, 325027, China.
authors: Yalong
authors: Y
authors: Hu
authors: National Engineering Research Center for Biomaterials, Sichuan University, Chengdu, 610064, China.
authors: Longgui
authors: L
authors: Zhang
authors: College of Chemistry and Materials Engineering, Wenzhou University, Wenzhou, 325027, China.
authors: Huayue
authors: H
authors: Wu
authors: National Engineering Research Center for Biomaterials, Sichuan University, Chengdu, 610064, China. Electronic address: bhe@scu.edu.cn.
authors: Bin
authors: B
authors: He
mesh_terms: D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage / Q000737:chemistry; D001897:Boronic Acids / Q000008:administration & dosage* / Q000737:chemistry; D045744:Cell Line, Tumor; D003692:Delayed-Action Preparations / Q000008:administration & dosage* / Q000737:chemistry; D004305:Dose-Response Relationship, Drug; D004317:Doxorubicin / Q000008:administration & dosage*; D020100:Hydrogels / Q000008:administration & dosage* / Q000737:chemistry; D015552:Injections, Intralesional; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008970:Molecular Weight; D053769:Nanocapsules / Q000008:administration & dosage* / Q000737:chemistry; D009374:Neoplasms, Experimental / Q000188:drug therapy* / Q000473:pathology; D016896:Treatment Outcome
chemical_list: D000903:Antibiotics, Antineoplastic; D001897:Boronic Acids; D003692:Delayed-Action Preparations; D020100:Hydrogels; D053769:Nanocapsules; D004317:Doxorubicin; C010686:benzeneboronic acid
keywords: Drug delivery; In situ chemotherapy; Intratumoral injection; Low molecular weight gels