title: Physiological and pathological clinical conditions and light scattering in brain.
abstract: MRI of preterm infants at term commonly reveals subtle brain lesions such as diffuse white matter injury, which are linked with later cognitive impairments. The timing and mechanism of such injury remains unclear. The reduced scattering coefficient of near-infrared light (μs') has been shown to correlate linearly with gestational age in neonates. To identify clinical variables associated with brain μs', 60 preterm and full-term infants were studied within 7 days of birth. Dependence of μs' obtained from the frontal head on clinical variables was assessed. In the univariate analysis, smaller μs' was associated with antenatal glucocorticoid, emergency Caesarean section, requirement for mechanical ventilation, smaller gestational age, smaller body sizes, low 1- and 5-minute Apgar scores, higher cord blood pH and PO2, and higher blood HCO3(-) at the time of study. Multivariate analysis revealed that smaller gestational age, requirement for mechanical ventilation, and higher HCO3(-) at the time of study were correlated with smaller μs'. Brain μs' depended on variables associated with physiological maturation and pathological conditions of the brain. Further longitudinal studies may help identify pathological events and clinical conditions responsible for subtle brain injury and subsequent cognitive impairments following preterm birth.
authors: Department of Paediatrics and Child Health, Centre for Developmental and Cognitive Neuroscience, Kurume University School of Medicine, 67 Asahimachi, Kurume, Fukuoka, 830-0011, Japan.|Community Medical Support Institute, Saga University School of Medicine, 5-1-1 Nabeshima, Saga, 849-8501, Japan.
authors: Tsuyoshi
authors: T
authors: Kurata
authors: Department of Paediatrics and Child Health, Centre for Developmental and Cognitive Neuroscience, Kurume University School of Medicine, 67 Asahimachi, Kurume, Fukuoka, 830-0011, Japan.
authors: Sachiko
authors: S
authors: Iwata
authors: Department of Paediatrics and Child Health, Centre for Developmental and Cognitive Neuroscience, Kurume University School of Medicine, 67 Asahimachi, Kurume, Fukuoka, 830-0011, Japan.|Division of Neonatology, Yokohama City University Medical Center, 4-57 Urafune, Minami-ku, Yokohama, Kanagawa, 232-0024, Japan.
authors: Kennosuke
authors: K
authors: Tsuda
authors: Department of Paediatrics and Child Health, Centre for Developmental and Cognitive Neuroscience, Kurume University School of Medicine, 67 Asahimachi, Kurume, Fukuoka, 830-0011, Japan.
authors: Masahiro
authors: M
authors: Kinoshita
authors: Department of Paediatrics and Child Health, Centre for Developmental and Cognitive Neuroscience, Kurume University School of Medicine, 67 Asahimachi, Kurume, Fukuoka, 830-0011, Japan.
authors: Mamoru
authors: M
authors: Saikusa
authors: Department of Paediatrics and Child Health, Centre for Developmental and Cognitive Neuroscience, Kurume University School of Medicine, 67 Asahimachi, Kurume, Fukuoka, 830-0011, Japan.
authors: Naoko
authors: N
authors: Hara
authors: Central Research Laboratory, Hamamatsu Photonics K.K., 5000 Hirakuchi, Hamakita-ku, Hamamatsu, Shizuoka, 434-8601, Japan.
authors: Motoki
authors: M
authors: Oda
authors: Central Research Laboratory, Hamamatsu Photonics K.K., 5000 Hirakuchi, Hamakita-ku, Hamamatsu, Shizuoka, 434-8601, Japan.
authors: Etsuko
authors: E
authors: Ohmae
authors: Faculty of Informatics, Shizuoka University, 3-5-1 Johoku Naka-ku, Hamamatsu, Shizuoka, 432-8011, Japan.
authors: Yuko
authors: Y
authors: Araki
authors: Community Medical Support Institute, Saga University School of Medicine, 5-1-1 Nabeshima, Saga, 849-8501, Japan.
authors: Takashi
authors: T
authors: Sugioka
authors: Yanagawa Institute for Developmental Disabilities, International University of Health and Welfare, 218-1 Tano-machi Mitsuhashi-machi, Yanagawa, Fukuoka, 832-0813, Japan.
authors: Sachio
authors: S
authors: Takashima
authors: Department of Paediatrics and Child Health, Centre for Developmental and Cognitive Neuroscience, Kurume University School of Medicine, 67 Asahimachi, Kurume, Fukuoka, 830-0011, Japan.
authors: Osuke
authors: O
authors: Iwata
mesh_terms: D001921:Brain / Q000000981:diagnostic imaging / Q000473:pathology*; D001930:Brain Injuries / Q000000981:diagnostic imaging* / Q000473:pathology; D000067493:Dynamic Light Scattering; D005260:Female; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D007236:Infant, Small for Gestational Age; D008137:Longitudinal Studies; D008279:Magnetic Resonance Imaging; D008297:Male