title: Clonal Evolution in Multiple Myeloma.
abstract: Multiple myeloma (MM) is the second most common hematologic malignancy encountered among patients in the United States. The last decade has seen incremental improvements in the survival of patients with MM. These advances are, to a large extent, attributable to the addition of proteasome inhibitors and immunomodulatory drugs to the armamentarium of treatment options. The adoption of these drug classes was the result of an empiric research paradigm. However, with the application of next generation sequencing technologies, we are now starting to unravel the genomic landscape of MM. It is hoped that this will allow us to better disentangle the biology of the disease and allow for identification of new therapeutic targets. In this article, we review what we have learned to date about the mutational profile, clonal architecture, and evolution of the disease, and discuss the potential clinical implications of these findings.
authors: Division of Hematology and Oncology, Washington University School of Medicine, St Louis, MO.
authors: Bita
authors: B
authors: Fakhri
authors: Division of Hematology and Oncology, Washington University School of Medicine, St Louis, MO. Electronic address: rvij@im.wustl.edu.
authors: Ravi
authors: R
authors: Vij
mesh_terms: D060965:Clonal Evolution / Q000235:genetics*; D056726:Genetic Association Studies; D018740:Genetic Heterogeneity; D020022:Genetic Predisposition to Disease; D023281:Genomics / Q000379:methods; D006801:Humans; D009101:Multiple Myeloma / Q000175:diagnosis / Q000235:genetics* / Q000401:mortality / Q000628:therapy; D009154:Mutation; D009367:Neoplasm Staging; D011379:Prognosis
keywords: Clonal evolution; Genomics; Multiple myeloma; Mutational landscape; Personalized medicine