title: Protein-like Nanoparticles Based on Orthogonal Self-Assembly of Chimeric Peptides.
abstract: A novel two-component self-assembling chimeric peptide is designed where two orthogonal protein folding motifs are linked side by side with precisely defined position relative to one another. The self-assembly is driven by a combination of symmetry controlled molecular packing, intermolecular interactions, and geometric constraint to limit the assembly into compact dodecameric protein nanoparticles.
authors: Department of Chemistry & Biomolecular Science, Clarkson University, 8 Clarkson Ave., Potsdam, NY, 13699, USA.
authors: Linhai
authors: L
authors: Jiang
authors: Department of Chemistry & Biomolecular Science, Clarkson University, 8 Clarkson Ave., Potsdam, NY, 13699, USA.
authors: Dawei
authors: D
authors: Xu
authors: Department of Biochemistry and Molecular Biology, SUNY Upstate Medical University, 766 Irving Ave., Syracuse, NY, 13210, USA.
authors: Kevin E
authors: KE
authors: Namitz
authors: Department of Biochemistry and Molecular Biology, SUNY Upstate Medical University, 766 Irving Ave., Syracuse, NY, 13210, USA.
authors: Michael S
authors: MS
authors: Cosgrove
authors: Department of Chemistry, University of Oslo, Oslo, 0315, Norway. reidar.lund@kjemi.uio.no.
authors: Reidar
authors: R
authors: Lund
authors: Department of Chemistry & Biomolecular Science, Clarkson University, 8 Clarkson Ave., Potsdam, NY, 13699, USA. hdong@clarkson.edu.
authors: He
authors: H
authors: Dong
mesh_terms: D000595:Amino Acid Sequence; D002942:Circular Dichroism; D003094:Collagen / Q000737:chemistry; D057446:Hydrodynamics; D053758:Nanoparticles / Q000737:chemistry*; D010455:Peptides / Q000737:chemistry*; D011506:Proteins / Q000737:chemistry*; D053838:Scattering, Small Angle; D014961:X-Ray Diffraction
chemical_list: D010455:Peptides; D011506:Proteins; D003094:Collagen
keywords: nanoparticles; peptides; protein folding; self-assembly