title: Pigmented Villonodular Synovitis: A Comprehensive Review and Proposed Treatment Algorithm.
abstract: Evidence now exists suggesting a neoplastic origin for pigmented villonodular synovitis, including a thorough description of the translocations involved. Arthroscopic excision for localized pigmented villonodular synovitis allows for both minimal recurrence and morbidity when compared with open excision; however, open excision still plays an important role in treating posterior compartment nodules. The optimal surgical treatment for diffuse pigmented villonodular synovitis is still a matter for debate, with combined anterior arthroscopic and open posterior excision being considered the preferred method. Radiation therapy has re-emerged as an additional treatment method for pigmented villonodular synovitis; however, the potential for serious toxicity makes it a questionable option, especially for such a benign condition. Small molecule and monoclonal antibody targeted therapies are being investigated as novel treatment methods for pigmented villonodular synovitis, with promising results.
authors: Department of Orthopaedic Surgery, Drexel University College of Medicine, Philadelphia, Pennsylvania.
authors: Stephen R
authors: SR
authors: Stephan
authors: Department of Orthopaedic Surgery, Drexel University College of Medicine, Philadelphia, Pennsylvania.
authors: Brandon
authors: B
authors: Shallop
authors: Cooper University Hospital, Camden, New Jersey.
authors: Richard
authors: R
authors: Lackman
authors: Cooper University Hospital, Camden, New Jersey.
authors: Tae Won B
authors: TWB
authors: Kim
authors: Department of Orthopaedic Surgery, Drexel University College of Medicine, Philadelphia, Pennsylvania.
authors: Mary K
authors: MK
authors: Mulcahey
mesh_terms: D000465:Algorithms; D006801:Humans; D009364:Neoplasm Recurrence, Local; D013586:Synovitis, Pigmented Villonodular / Q000175:diagnosis / Q000628:therapy*