title: Effects of Marijuana Use on Brain Structure and Function: Neuroimaging Findings from a Neurodevelopmental Perspective.
abstract: Marijuana, behind only tobacco and alcohol, is the most popular recreational drug in America with prevalence rates of use rising over the past decade. A wide range of research has highlighted neurocognitive deficits associated with marijuana use, particularly when initiated during childhood or adolescence. Neuroimaging, describing alterations to brain structure and function, has begun to provide a picture of possible mechanisms associated with the deleterious effects of marijuana use. This chapter provides a neurodevelopmental framework from which recent data on brain structural and functional abnormalities associated with marijuana use is reviewed. Based on the current data, we provide aims for future studies to more clearly delineate the effects of marijuana on the developing brain and to define underlying mechanisms of the potential long-term negative consequences of marijuana use.
authors: University of California, San Diego, La Jolla, CA, United States; VA San Diego Healthcare System, San Diego, CA, United States. Electronic address: tbrumback@ucsd.edu.
authors: T
authors: T
authors: Brumback
authors: University of California, San Diego, La Jolla, CA, United States.
authors: N
authors: N
authors: Castro
authors: University of California, San Diego, La Jolla, CA, United States; VA San Diego Healthcare System, San Diego, CA, United States.
authors: J
authors: J
authors: Jacobus
authors: University of California, San Diego, La Jolla, CA, United States.
authors: S
authors: S
authors: Tapert
mesh_terms: D001921:Brain / Q000000981:diagnostic imaging* / Q000254:growth & development*; D063388:Endocannabinoids / Q000378:metabolism; D006801:Humans; D002189:Marijuana Abuse / Q000000981:diagnostic imaging / Q000473:pathology*; D059906:Neuroimaging
chemical_list: D063388:Endocannabinoids
keywords: Adolescence; Cannabis; Endocannabinoids; Marijuana; Neurodevelopment