title: Interrupting prolonged sitting with brief bouts of light walking or simple resistance activities reduces resting blood pressure and plasma noradrenaline in type 2 diabetes.
abstract: Prolonged sitting is increasingly recognized as a ubiquitous cardiometabolic risk factor, possibly distinct from lack of physical exercise. We examined whether interrupting prolonged sitting with brief bouts of light-intensity activity reduced blood pressure (BP) and plasma noradrenaline in type 2 diabetes (T2D).
  
  
  
  In a randomized crossover trial, 24 inactive overweight/obese adults with T2D (14 men; mean ± SD; 62 ± 6 years) consumed standardized meals during 3 × 8 h conditions: uninterrupted sitting (SIT); sitting + half-hourly bouts of walking (3.2 km/h for 3-min) (light-intensity walking); and sitting + half-hourly bouts of simple resistance activities for 3 min (SRAs), each separated by 6-14 days washout. Resting seated BP was measured hourly (mean of three recordings, ≥20-min postactivity). Plasma noradrenaline was measured at 30-min intervals for the first hour after meals and hourly thereafter.
  
  
  
  Compared with SIT, mean resting SBP and DBP were significantly reduced (P < 0.001) for both light-intensity walking (mean ± SEM; -14 ± 1/-8 ± 1 mmHg) and SRA (-16 ± 1/-10 ± 1 mmHg), with a more pronounced effect for SRA (P < 0.05 versus light-intensity walking). Similarly, mean plasma noradrenaline was significantly reduced for both light-intensity walking (-0.3 ± 0.1 nmol/l) and SRA (-0.6 ± 0.1 nmol/l) versus SIT, with SRA lower than light-intensity walking (P < 0.05). Mean resting heart rate was lowered by light-intensity walking (-3 ± 1 bpm; P < 0.05), but not SRA (-1 ± 1 bpm).
  
  
  
  Interrupting prolonged sitting with brief bouts of light-intensity walking or SRA reduces resting BP and plasma noradrenaline in adults with T2D, with SRA being more effective. Given the ubiquity of sedentary behaviors and poor adherence to structured exercise, this approach may have important implications for BP management in patients with T2D.
authors: aBaker IDI Heart & Diabetes Institute bCentral Clinical School, Faculty of Medicine, Nursing & Health Sciences, Monash University cCentre of Physical Activity and Nutrition Research, School of Exercise and Nutrition Sciences, Deakin University, Melbourne, Victoria, Australia dSchool of Public Health, The University of Hong Kong, Hong Kong, China eMary MacKillop Institute of Health Research, Australian Catholic University, Melbourne, Victoria, Australia fSchool of Public Health, The University of Queensland, Brisbane, Queensland gSchool of Sport Science, Exercise and Health, The University of Western Australia, Perth, Western Australia hSwinburne University of Technology iSchool of Population and Global Health, The University of Melbourne jInstitute for Health and Ageing, Australian Catholic University, Melbourne, Victoria, Australia.
authors: Paddy C
authors: PC
authors: Dempsey
authors: Julian W
authors: JW
authors: Sacre
authors: Robyn N
authors: RN
authors: Larsen
authors: Nora E
authors: NE
authors: Straznicky
authors: Parneet
authors: P
authors: Sethi
authors: Neale D
authors: ND
authors: Cohen
authors: Ester
authors: E
authors: Cerin
authors: Gavin W
authors: GW
authors: Lambert
authors: Neville
authors: N
authors: Owen
authors: Bronwyn A
authors: BA
authors: Kingwell
authors: David W
authors: DW
authors: Dunstan
mesh_terms: D000368:Aged; D001794:Blood Pressure; D018592:Cross-Over Studies; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000150:complications / Q000503:physiopathology*; D005260:Female; D006339:Heart Rate; D006801:Humans; D008297:Male; D008875:Middle Aged; D009638:Norepinephrine / Q000097:blood*; D009765:Obesity / Q000097:blood / Q000150:complications / Q000503:physiopathology*; D011187:Posture / Q000502:physiology*; D055070:Resistance Training; D012146:Rest / Q000502:physiology; D016138:Walking / Q000502:physiology*
chemical_list: D009638:Norepinephrine