title: Persistent reflux symptoms cause anxiety, depression, and mental health and sleep disorders in gastroesophageal reflux disease patients.
abstract: Some patients with gastroesophageal reflux disease experience persistent reflux symptoms despite proton pump inhibitor therapy. These symptoms reduce their health-related quality of life. Our aims were to evaluate the relationship between proton pump inhibitor efficacy and health-related quality of life and to evaluate predictive factors affecting treatment response in Japanese patients. Using the gastroesophageal reflux disease questionnaire, 145 gastroesophageal reflux disease patients undergoing proton pump inhibitor therapy were evaluated and classified as responders or partial-responders. Their health-related quality of life was then evaluated using the 8-item Short Form Health Survey, the Pittsburgh Sleep Quality Index, and the Hospital Anxiety and Depression Scale questionnaires. Sixty-nine patients (47.6%) were partial responders. These patients had significantly lower scores than responders in 5/8 subscales and in the mental health component summary of the 8-item Short Form Health Survey. Partial responders had significantly higher Pittsburgh Sleep Quality Index and Hospital Anxiety and Depression Scale scores, including anxiety and depression scores, than those of responders. Non-erosive reflux disease and double proton pump inhibitor doses were predictive factors of partial responders. Persistent reflux symptoms, despite proton pump inhibitor therapy, caused mental health disorders, sleep disorders, and psychological distress in Japanese gastroesophageal reflux disease patients.
authors: Department of Gastroenterology, Nagoya City West Medical Center, 1-1-1 Hirate-cho, Kita-ku, Nagoya 462-8508, Japan.
authors: Yoshihide
authors: Y
authors: Kimura
authors: Department of Medical Innovation, Nagoya City University Graduate School of Medical Sciences, 1 Mizuho-cho, Mizuho-ku, Nagoya 467-8601, Japan.
authors: Takeshi
authors: T
authors: Kamiya
authors: Department of Gastroenterology, Nagoya City West Medical Center, 1-1-1 Hirate-cho, Kita-ku, Nagoya 462-8508, Japan.
authors: Kyouji
authors: K
authors: Senoo
authors: Department of Gastroenterology, Nagoya City West Medical Center, 1-1-1 Hirate-cho, Kita-ku, Nagoya 462-8508, Japan.
authors: Kenji
authors: K
authors: Tsuchida
authors: Department of Gastroenterology, Nagoya City West Medical Center, 1-1-1 Hirate-cho, Kita-ku, Nagoya 462-8508, Japan.
authors: Atsuyuki
authors: A
authors: Hirano
authors: Department of Gastroenterology, Nagoya City West Medical Center, 1-1-1 Hirate-cho, Kita-ku, Nagoya 462-8508, Japan.
authors: Hisayo
authors: H
authors: Kojima
authors: Department of Gastroenterology, Nagoya City West Medical Center, 1-1-1 Hirate-cho, Kita-ku, Nagoya 462-8508, Japan.
authors: Hiroaki
authors: H
authors: Yamashita
authors: Department of Gastroenterology, Nagoya City West Medical Center, 1-1-1 Hirate-cho, Kita-ku, Nagoya 462-8508, Japan.
authors: Yoshihiro
authors: Y
authors: Yamakawa
authors: Department of Gastroenterology, Nagoya City West Medical Center, 1-1-1 Hirate-cho, Kita-ku, Nagoya 462-8508, Japan.
authors: Nobuhiro
authors: N
authors: Nishigaki
authors: Department of Gastroenterology, Nagoya City West Medical Center, 1-1-1 Hirate-cho, Kita-ku, Nagoya 462-8508, Japan.
authors: Tomonori
authors: T
authors: Ozeki
authors: Department of Gastroenterology, Nagoya City West Medical Center, 1-1-1 Hirate-cho, Kita-ku, Nagoya 462-8508, Japan.
authors: Masatsugu
authors: M
authors: Endo
authors: Department of Gastroenterology, Nagoya City West Medical Center, 1-1-1 Hirate-cho, Kita-ku, Nagoya 462-8508, Japan.
authors: Kazuhisa
authors: K
authors: Nakanishi
authors: Department of Gastroenterology, Nagoya City West Medical Center, 1-1-1 Hirate-cho, Kita-ku, Nagoya 462-8508, Japan.
authors: Motoki
authors: M
authors: Sando
authors: Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, 1 Mizuho-cho, Mizuho-ku, Nagoya 467-8601, Japan.
authors: Yusuke
authors: Y
authors: Inagaki
authors: Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, 1 Mizuho-cho, Mizuho-ku, Nagoya 467-8601, Japan.
authors: Michiko
authors: M
authors: Shikano
authors: Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, 1 Mizuho-cho, Mizuho-ku, Nagoya 467-8601, Japan.
authors: Tsutomu
authors: T
authors: Mizoshita
authors: Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, 1 Mizuho-cho, Mizuho-ku, Nagoya 467-8601, Japan.
authors: Eiji
authors: E
authors: Kubota
authors: Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, 1 Mizuho-cho, Mizuho-ku, Nagoya 467-8601, Japan.
authors: Satoshi
authors: S
authors: Tanida
authors: Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, 1 Mizuho-cho, Mizuho-ku, Nagoya 467-8601, Japan.
authors: Hiromi
authors: H
authors: Kataoka
authors: Department of Gastroenterology, Nagoya City West Medical Center, 1-1-1 Hirate-cho, Kita-ku, Nagoya 462-8508, Japan.
authors: Kohei
authors: K
authors: Katsumi
authors: Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, 1 Mizuho-cho, Mizuho-ku, Nagoya 467-8601, Japan.
authors: Takashi
authors: T
authors: Joh
keywords: 8-item Short Form Health Survey; Hospital Anxiety and Depression Scale; Pittsburgh Sleep Quality Index; gastroesophageal reflux disease; health-related quality of life