title: High prevalence of undiagnosed liver cirrhosis and advanced fibrosis in type 2 diabetic patients.
abstract: Background. Patients with type 2 diabetes mellitus (T2DM) are at risk for developing end-stage liver disease due to nonalcoholic steatohepatitis (NASH), the aggressive form of non-alcoholic fatty liver disease (NAFLD). Data on prevalence of advanced fibrosis among T2DM patients is scarce.
  
  
  OBJECTIVE
  To evaluate prevalence of steatosis, advanced fibrosis and cirrhosis using non-invasive methods in T2DM patients.
  
  
  METHODS
  145 consecutive T2DM patients (> 55 years-old) were prospectively recruited. Presence of cirrhosis and advanced fibrosis was evaluated by magnetic resonance imaging (MRI) and NAFLD fibrosis score (NFS) respectively. Exclusion criteria included significant alcohol consumption, markers of viral hepatitis infection or other liver diseases. Results are expressed in percentage or median (interquartile range).
  
  
  RESULTS
  52.6% of patients were women, the median age was 60 years old (57-64), mean BMI was 29.6 ± 4.7 kg/m2 and diabetes duration was 7.6 ± 6.9 years. A high prevalence of liver steatosis (63.9%), advanced fibrosis assessed by NFS (12.8%) and evidence of liver cirrhosis in MRI (6.0%) was observed. In a multivariate analysis GGT > 82 IU/L (P = 0.004) and no alcohol intake (P = 0.032) were independently associated to advanced fibrosis.
  
  
  CONCLUSIONS
  A high frequency of undiagnosed advanced fibrosis and cirrhosis was observed in non-selected T2DM patients. Screening of these conditions may be warranted in this patient population.
authors: Departamento de Gastroenterología, Pontificia Universidad Católica de Chile, Santiago, Chile.
authors: Juan P
authors: JP
authors: Arab
authors: Departamento de Gastroenterología, Pontificia Universidad Católica de Chile, Santiago, Chile.
authors: Francisco
authors: F
authors: Barrera
authors: Departamento de Nutrición, Pontificia Universidad Católica de Chile, Santiago, Chile.
authors: Consuelo
authors: C
authors: Gallego
authors: Departamento de Nutrición, Pontificia Universidad Católica de Chile, Santiago, Chile.
authors: Juan P
authors: JP
authors: Valderas
authors: Departamento de Radiología, Pontificia Universidad Católica de Chile, Santiago, Chile.
authors: Sergio
authors: S
authors: Uribe
authors: Escuela de Medicina and Departamento de Ingeniería Eléctrica, Escuela de Ingeniería, Pontificia Universidad Católica de Chile, Santiago, Chile.
authors: Cristian
authors: C
authors: Tejos
authors: Departamento de Radiología, Pontificia Universidad Católica de Chile, Santiago, Chile.
authors: Cristóbal
authors: C
authors: Serrano
authors: Departamento de Radiología, Pontificia Universidad Católica de Chile, Santiago, Chile.
authors: Cristóbal
authors: C
authors: Serrano
authors: Departamento de Radiología, Pontificia Universidad Católica de Chile, Santiago, Chile.
authors: Álvaro
authors: Á
authors: Huete
authors: Departamento de Nutrición, Pontificia Universidad Católica de Chile, Santiago, Chile.
authors: Jessica
authors: J
authors: Liberona
authors: Departamento de Gastroenterología, Pontificia Universidad Católica de Chile, Santiago, Chile.
authors: Pilar
authors: P
authors: Labbé
authors: Departamento de Laboratorio Clínico, Pontificia Universidad Católica de Chile, Santiago, Chile.
authors: Teresa
authors: T
authors: Quiroga
authors: Departamento de Gastroenterología, Pontificia Universidad Católica de Chile, Santiago, Chile.
authors: Carlos
authors: C
authors: Benítez
authors: Escuela de Medicina and Departamento de Ingeniería Eléctrica, Escuela de Ingeniería, Pontificia Universidad Católica de Chile, Santiago, Chile.
authors: Pablo
authors: P
authors: Irarrázaval
authors: Departamento de Gastroenterología, Pontificia Universidad Católica de Chile, Santiago, Chile.
authors: Arnoldo
authors: A
authors: Riquelme
authors: Departamento de Gastroenterología, Pontificia Universidad Católica de Chile, Santiago, Chile.
authors: Marco
authors: M
authors: Arrese
mesh_terms: D015415:Biomarkers / Q000097:blood; D016009:Chi-Square Distribution; D002677:Chile / Q000453:epidemiology; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000175:diagnosis / Q000453:epidemiology*; D018450:Disease Progression; D005260:Female; D006801:Humans; D008103:Liver Cirrhosis / Q000097:blood / Q000175:diagnosis / Q000453:epidemiology*; D016015:Logistic Models; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D016017:Odds Ratio; D015995:Prevalence; D011446:Prospective Studies; D012307:Risk Factors
chemical_list: D015415:Biomarkers