title: Endothelial Transcytosis of Insulin: Does It Contribute to Insulin Resistance?
abstract: Most research on insulin resistance has focused on impaired signaling at the level of target tissues like skeletal muscle. Insulin delivery is also important and includes recruitment and perfusion of capillaries bearing insulin, but also the transit of insulin across the capillary endothelium. The mechanisms of this second stage (insulin transcytosis) and whether it contributes to insulin resistance remain uncertain.
authors: Keenan Research Centre for Biomedical Science, St. Michael's Hospital, Toronto, Canada; Department of Medicine, University of Toronto, Toronto, Canada; Department of Biochemistry, University of Toronto, Toronto, Canada; Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Canada; and leew@smh.ca.
authors: Warren L
authors: WL
authors: Lee
authors: Cell Biology Program, The Hospital for Sick Children, Toronto, Canada; Department of Biochemistry, University of Toronto, Toronto, Canada; Paediatrics, and Physiology, University of Toronto, Toronto, Canada.
authors: Amira
authors: A
authors: Klip
mesh_terms: D000818:Animals; D002199:Capillary Permeability; D042783:Endothelial Cells / Q000502:physiology*; D006801:Humans; D007328:Insulin / Q000502:physiology*; D007333:Insulin Resistance; D051379:Mice; D018482:Muscle, Skeletal / Q000098:blood supply / Q000503:physiopathology*; D011972:Receptor, Insulin / Q000502:physiology; D057900:Transcytosis
chemical_list: D007328:Insulin; D011972:Receptor, Insulin