title: On-Demand Removal of Bacterial Biofilms via Shape Memory Activation.
abstract: Bacterial biofilms are a major cause of chronic infections and biofouling; however, effective removal of established biofilms remains challenging. Here we report a new strategy for biofilm control using biocompatible shape memory polymers with defined surface topography. These surfaces can both prevent bacterial adhesion and remove established biofilms upon rapid shape change with moderate increase of temperature, thereby offering more prolonged antifouling properties. We demonstrate that this strategy can achieve a total reduction of Pseudomonas aeruginosa biofilms by 99.9% compared to the static flat control. It was also found effective against biofilms of Staphylococcus aureus and an uropathogenic strain of Escherichia coli.
authors: Department of Biomedical and Chemical Engineering, §Syracuse Biomaterials Institute, ⊥Department of Civil and Environmental Engineering, and ∥Department of Biology, Syracuse University , Syracuse, New York 13244, United States.
authors: Huan
authors: H
authors: Gu
authors: Department of Biomedical and Chemical Engineering, §Syracuse Biomaterials Institute, ⊥Department of Civil and Environmental Engineering, and ∥Department of Biology, Syracuse University , Syracuse, New York 13244, United States.
authors: Sang Won
authors: SW
authors: Lee
authors: Department of Biomedical and Chemical Engineering, §Syracuse Biomaterials Institute, ⊥Department of Civil and Environmental Engineering, and ∥Department of Biology, Syracuse University , Syracuse, New York 13244, United States.
authors: Shelby Lois
authors: SL
authors: Buffington
authors: Department of Biomedical and Chemical Engineering, §Syracuse Biomaterials Institute, ⊥Department of Civil and Environmental Engineering, and ∥Department of Biology, Syracuse University , Syracuse, New York 13244, United States.
authors: James H
authors: JH
authors: Henderson
authors: Department of Biomedical and Chemical Engineering, §Syracuse Biomaterials Institute, ⊥Department of Civil and Environmental Engineering, and ∥Department of Biology, Syracuse University , Syracuse, New York 13244, United States.
authors: Dacheng
authors: D
authors: Ren
mesh_terms: D001422:Bacterial Adhesion; D018441:Biofilms; D057219:Biofouling; D011550:Pseudomonas aeruginosa; D013211:Staphylococcus aureus
keywords: antibiofouling surfaces; biofilm; shape memory polymer; surface topography; temperature-responsive material