title: Glial cell line-derived neurotrophic factor in genetically defined fear-induced aggression.
abstract: Glial cell line-derived neurotrophic factor (GDNF) plays an important role in maintenance of neuronal system throughout life. However, there is a lack of data on the involvement of GDNF in the regulation of different kinds of behavior. In this study, GDNF, its precursor (proGDNF) and GDNF mRNA levels were investigated in the brain of rats selectively bred for 85 generations for either high level or for the lack of affective aggressiveness toward human. It was found that GDNF mRNA level was decreased in the frontal cortex, increased in the raphe nuclei area of the midbrain of aggressive rats compared to tame animals and was not detected in the amygdala and hypothalamus. The level of proGDNF was reduced in the raphe nuclei area of the midbrain of highly aggressive rats and was not detected in the striatum, nucleus accumbens of investigated animals. Two forms of mature GDNF - monomer and dimer - were revealed. GDNF monomer level was increased in the raphe nuclei area, substantia nigra and amygdala of aggressive rats and it was not found in the frontal cortex and nucleus accumbens of investigated rats. Dimer GDNF level was found in all investigated brain structures. It was reduced in the hippocampus and increased in amygdala of highly aggressive rats. Thus, considerable structure-specific differences in GDNF expression between highly aggressive and nonaggressive rats were shown. The data suggested the implication of both mature GDNF monomer and dimer as well as proGDNF in the mechanism underlying genetically defined aggressiveness.
authors: Department of Behavioral Neurogenomics, Federal Research Center Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Science, Lavrentyeva av. 10, Novosibirsk, 630090, Russia.
authors: Tatiana V
authors: TV
authors: Ilchibaeva
authors: Department of Behavioral Neurogenomics, Federal Research Center Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Science, Lavrentyeva av. 10, Novosibirsk, 630090, Russia.
authors: Anton S
authors: AS
authors: Tsybko
authors: Laboratory of Evolutionary Genetics, Federal Research Center Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Science, Novosibirsk, Russia.
authors: Rimma V
authors: RV
authors: Kozhemyakina
authors: Department of Behavioral Neurogenomics, Federal Research Center Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Science, Lavrentyeva av. 10, Novosibirsk, 630090, Russia.
authors: Nina K
authors: NK
authors: Popova
authors: Department of Behavioral Neurogenomics, Federal Research Center Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Science, Lavrentyeva av. 10, Novosibirsk, 630090, Russia. naumenko2002@bionet.nsc.ru.
authors: Vladimir S
authors: VS
authors: Naumenko
mesh_terms: D000374:Aggression / Q000502:physiology*; D000818:Animals; D003342:Corpus Striatum / Q000378:metabolism; D005239:Fear / Q000502:physiology*; D005625:Frontal Lobe / Q000378:metabolism; D051100:Glial Cell Line-Derived Neurotrophic Factor / Q000235:genetics / Q000378:metabolism*; D006624:Hippocampus / Q000378:metabolism*; D051096:Proto-Oncogene Proteins c-ret / Q000378:metabolism; D051381:Rats; D013378:Substantia Nigra / Q000378:metabolism*
chemical_list: D051100:Glial Cell Line-Derived Neurotrophic Factor; D051096:Proto-Oncogene Proteins c-ret
keywords: GDNF levels and proGDNF levels; GDNF mRNA level; GDNF monomer and dimer; genetically defined aggression in rats; glial cell line-derived neurotrophic factor