title: Poly(polyol sebacate) Elastomers as Coatings for Metallic Coronary Stents.
abstract: Biocompatible polymeric coatings for metallic stents are desired, as currently used materials present limitations such as deformation during degradation and exponential loss of mechanical properties after implantation. These concerns, together with the present risks of the drug-eluting stents, namely, thrombosis and restenosis, require new materials to be studied. For this purpose, novel poly(polyol sebacate)-derived polymers are investigated as coatings for metallic stents. All pre-polymers reveal a low molecular weight between 3000 and 18 000 g mol-1. The cured polymers range from flexible to more rigid, with E-modulus between 0.6 and 3.8 MPa. Their advantages include straightforward synthesis, biodegradability, easy processing through different scaffolding techniques, and easy transfer to industrial production. Furthermore, electrospraying and dip-coating procedures are used as proof-of-concept to create coatings on metallic stents. Biocompatibility tests using adipose stem cells lead to promising results for the use of these materials as coatings for metallic coronary stents.
authors: Centro Científico Tecnológico, Ruta Nacional 168, Paraje El Pozo 3000, Santa Fe, Argentina.
authors: Lucila
authors: L
authors: Navarro
authors: Polymer Chemistry and Biomaterials Research Group, Ghent University, Krijgslaan 281, Building S4, Ghent, 9000, Belgium.|Center for Microsystem Technology, Ghent University, Technologiepark - iGent floor 6e, Gent-Zwijnaarde, 9052, Belgium.
authors: Diana-Elena
authors: DE
authors: Mogosanu
authors: Academic Centre for Dentistry Amsterdam, Department of Oral Cell Biology, Gustav Mahlerlaan 3004 - Room 11N43, 1081, LA Amsterdam, The Netherlands.
authors: Thijs
authors: T
authors: de Jong
authors: Academic Centre for Dentistry Amsterdam, Department of Oral Cell Biology, Gustav Mahlerlaan 3004 - Room 11N43, 1081, LA Amsterdam, The Netherlands.
authors: Astrid D
authors: AD
authors: Bakker
authors: Center for Microsystem Technology, Ghent University, Technologiepark - iGent floor 6e, Gent-Zwijnaarde, 9052, Belgium.
authors: David
authors: D
authors: Schaubroeck
authors: Centro Científico Tecnológico, Ruta Nacional 168, Paraje El Pozo 3000, Santa Fe, Argentina.
authors: Julio
authors: J
authors: Luna
authors: Centro Científico Tecnológico, Ruta Nacional 168, Paraje El Pozo 3000, Santa Fe, Argentina.
authors: Ignacio
authors: I
authors: Rintoul
authors: Center for Microsystem Technology, Ghent University, Technologiepark - iGent floor 6e, Gent-Zwijnaarde, 9052, Belgium.
authors: Jan
authors: J
authors: Vanfleteren
authors: Polymer Chemistry and Biomaterials Research Group, Ghent University, Krijgslaan 281, Building S4, Ghent, 9000, Belgium.
authors: Peter
authors: P
authors: Dubruel
mesh_terms: D000273:Adipose Tissue / Q000166:cytology / Q000378:metabolism*; D000328:Adult; D020099:Coated Materials, Biocompatible / Q000737:chemistry / Q000494:pharmacology; D054855:Drug-Eluting Stents; D005260:Female; D006801:Humans; D008422:Materials Testing; D008875:Middle Aged; D011108:Polymers / Q000737:chemistry / Q000494:pharmacology; D013234:Stem Cells / Q000166:cytology / Q000378:metabolism*
chemical_list: D020099:Coated Materials, Biocompatible; D011108:Polymers
keywords: biocompatible; coatings; metallic stents; poly(polyol-sebacate)s