title: Attenuation of Aβ toxicity by promotion of mitochondrial fusion in neuroblastoma cells by liquiritigenin.
abstract: Mitochondrial dynamics control mitochondrial morphology and function, and aberrations in these are associated with various neurodegenerative diseases including Alzheimer's disease and Parkinson's disease. To identify novel regulators of mitochondrial dynamics, we screened a phytochemical library and identified liquiritigenin as a potent inducer of mitochondrial fusion. Treatment with liquiritigenin induced an elongated mitochondrial morphology in SK-N-MC cells. In addition, liquiritigenin rescued mitochondrial fragmentation induced by knockout of mitochondrial fusion mediators such as Mfn1, Mfn2, and Opa1. Furthermore, we found that treatment with liquiritigenin notably inhibited mitochondrial fragmentation and cytotoxicity induced by Aβ in SK-N-MC cells.
authors: Graduate School of East-West Medical Science, Kyung Hee University, Yongin-Si, Gyeonggi-Do, 17104, Republic of Korea.
authors: Doo Sin
authors: DS
authors: Jo
authors: Graduate School of East-West Medical Science, Kyung Hee University, Yongin-Si, Gyeonggi-Do, 17104, Republic of Korea.
authors: Dong Woon
authors: DW
authors: Shin
authors: Graduate School of East-West Medical Science, Kyung Hee University, Yongin-Si, Gyeonggi-Do, 17104, Republic of Korea.
authors: So Jung
authors: SJ
authors: Park
authors: Graduate School of East-West Medical Science, Kyung Hee University, Yongin-Si, Gyeonggi-Do, 17104, Republic of Korea.
authors: Ji-Eun
authors: JE
authors: Bae
authors: Graduate School of East-West Medical Science, Kyung Hee University, Yongin-Si, Gyeonggi-Do, 17104, Republic of Korea.
authors: Joon Bum
authors: JB
authors: Kim
authors: Graduate School of East-West Medical Science, Kyung Hee University, Yongin-Si, Gyeonggi-Do, 17104, Republic of Korea.
authors: Na Yeon
authors: NY
authors: Park
authors: Division of Radiation Cancer Research, Korea Institute of Radiological and Medical Science, Seoul, 01812, Republic of Korea.
authors: Jae-Sung
authors: JS
authors: Kim
authors: Department of Genetic Engineering, College of Biotechnology and Bioengineering, Sungkyunkwan University, Suwon, 16356, Republic of Korea.
authors: Jeong Su
authors: JS
authors: Oh
authors: Graduate School of East-West Medical Science, Kyung Hee University, Yongin-Si, Gyeonggi-Do, 17104, Republic of Korea. shinarago@khu.ac.kr.|Graduate School of East-West Medical Science, Kyung Hee University, 1732, Deogyeong-daero, Giheung-gu, Yongin-Si, Gyeonggi-Do, 17104, Republic of Korea. shinarago@khu.ac.kr.
authors: Jung-Won
authors: JW
authors: Shin
authors: Graduate School of East-West Medical Science, Kyung Hee University, Yongin-Si, Gyeonggi-Do, 17104, Republic of Korea. dhcho@khu.ac.kr.|Graduate School of East-West Medical Science, Kyung Hee University, 1732, Deogyeong-daero, Giheung-gu, Yongin-Si, Gyeonggi-Do, 17104, Republic of Korea. dhcho@khu.ac.kr.
authors: Dong-Hyung
authors: DH
authors: Cho
mesh_terms: D016229:Amyloid beta-Peptides / Q000633:toxicity*; D000818:Animals; D016923:Cell Death / Q000187:drug effects / Q000502:physiology; D045744:Cell Line, Tumor; D044950:Flavanones / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D055786:Gene Knockout Techniques; D006801:Humans; D051379:Mice; D063154:Mitochondrial Dynamics / Q000187:drug effects* / Q000502:physiology; D009447:Neuroblastoma / Q000188:drug therapy / Q000378:metabolism* / Q000473:pathology; D010446:Peptide Fragments / Q000633:toxicity*
chemical_list: D016229:Amyloid beta-Peptides; D044950:Flavanones; D010446:Peptide Fragments; C075222:amyloid beta-protein (1-42); C083152:liquiritigenin
keywords: Amyloid beta; Fusion/fission; Liquiritigenin; Mitochondria dynamics