title: Outdoor air pollution and human infertility: a systematic review.
abstract: Air pollution is a current research priority because of its adverse effects on human health, including on fertility. However, the mechanisms through which air pollution impairs fertility remain unclear. In this article, we perform a systematic review to evaluate currently available evidence on the impact of air pollution on fertility in humans. Several studies have assessed the impact of air pollutants on the general population, and have found reduced fertility rates and increased risk of miscarriage. In subfertile patients, women exposed to higher concentrations of air pollutants while undergoing IVF showed lower live birth rates and higher rates of miscarriage. After exposure to similar levels of air pollutants, comparable results have been found regardless of the mode of conception (IVF versus spontaneous conception), suggesting that infertile women are not more susceptible to the effects of pollutants than the general population. In addition, previous studies have not observed impaired embryo quality after exposure to air pollution, although evidence for this question is sparse.
authors: Department of Obstetrics and Gynaecology, Hospital del Mar, Barcelona, Spain; Universitat Autònoma de Barcelona, Barcelona, Spain; GRI-BCN (Barcelona Research Infertility Group), Barcelona, Spain. Electronic address: macheca@parcdesalutmar.cat.
authors: Miguel A
authors: MA
authors: Checa Vizcaíno
authors: Department of Obstetrics and Gynaecology, Hospital del Mar, Barcelona, Spain; Universitat Autònoma de Barcelona, Barcelona, Spain; GRI-BCN (Barcelona Research Infertility Group), Barcelona, Spain.
authors: Mireia
authors: M
authors: González-Comadran
authors: Centre for Research in Epidemiology and Population Health (CESP), U1018, Respiratory and Environmental Epidemiology Team, INSERM, Villejuif, France; UMRS 1018, Université Paris Sud, Villejuif, France; Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain.
authors: Benedicte
authors: B
authors: Jacquemin
mesh_terms: D000393:Air Pollutants / Q000009:adverse effects*; D000397:Air Pollution / Q000009:adverse effects*; D010064:Embryo Implantation / Q000187:drug effects; D052244:Endocrine Disruptors / Q000009:adverse effects*; D004781:Environmental Exposure / Q000009:adverse effects*; D005260:Female; D005298:Fertility / Q000187:drug effects*; D006801:Humans; D007246:Infertility / Q000139:chemically induced* / Q000175:diagnosis / Q000503:physiopathology / Q000628:therapy; D050498:Live Birth; D008297:Male; D011247:Pregnancy; D011248:Pregnancy Complications / Q000139:chemically induced; D018873:Pregnancy Rate; D012098:Reproduction / Q000187:drug effects*; D027724:Reproductive Techniques, Assisted / Q000009:adverse effects; D018570:Risk Assessment; D012307:Risk Factors
chemical_list: D000393:Air Pollutants; D052244:Endocrine Disruptors
keywords: Air pollution; fertility; live birth; miscarriage