title: Lack of Agreement Between Endocervical Brush and Endocervical Curettage in Women Undergoing Repeat Endocervical Sampling.
abstract: OBJECTIVE
  To evaluate agreement between an abnormal endocervical brush (ECB) collected at the time of colposcopy and subsequent endocervical curettage (ECC).
  
  
  METHODS
  All women evaluated for lower genital tract disease at a single academic institution were prospectively entered into a database. The database was queried for those who had a colposcopic exam with ECB between April 1, 2013, and June 15, 2015, and who subsequently returned for an ECC to further evaluate eligibility for expectant management or ablative therapy. ECB and ECC results were divided into 2 groups: "low-grade" included low-grade squamous intraepithelial lesions (LSIL) or atypical squamous cells of undetermined significance, and "high-grade" included high-grade squamous intraepithelial lesions (HSIL) or atypical squamous cells-cannot exclude high-grade. Women with atypical glandular cells and unsatisfactory ECB results were excluded. Percent agreement between ECB and ECC was calculated based on these categories.
  
  
  RESULTS
  Seventy-nine women were included: 54 (68%) had a low-grade ECB, and 25 (32%) had a high-grade ECB. Of those who had a low-grade ECB, 4 had a low-grade ECC, 3 had a high-grade ECC, and 47 were negative, resulting in an agreement of 7.4% (4/54). Of those who had a high-grade ECB, 1 had a low-grade ECC, 4 had a high-grade ECC, and 20 were negative, resulting in 16% (4/25) agreement.
  
  
  CONCLUSIONS
  Our data suggest that there is poor agreement between ECC and ECB in our patient population.
authors: 1University of Colorado, Department of Obstetrics and Gynecology, Aurora, Colorado; and 2Denver Health Medical Center, Department of Obstetrics and Gynecology, Denver, Colorado.
authors: David W
authors: DW
authors: Doo
authors: Elaine H
authors: EH
authors: Stickrath
authors: Sara E
authors: SE
authors: Mazzoni
authors: Meredith J
authors: MJ
authors: Alston
mesh_terms: D000328:Adult; D002584:Cervix Uteri / Q000473:pathology*; D005260:Female; D006801:Humans; D008875:Middle Aged; D010338:Pathology, Clinical / Q000379:methods*; D011446:Prospective Studies; D013048:Specimen Handling / Q000379:methods*; D002583:Uterine Cervical Neoplasms / Q000175:diagnosis*