title: Comparison between dynamic susceptibility contrast magnetic resonance imaging and arterial spin labeling techniques in distinguishing malignant from benign brain tumors.
abstract: OBJECTIVE
  The purpose of this study was to preliminarily compare unenhanced arterial spin-labeled (ASL) imaging, dynamic susceptibility contrast-enhanced cerebral blood volume (DSCE-CBV) magnetic resonance imaging (MRI) for evaluation of tumor perfusion in patients with brain tumors.
  
  
  METHODS
  A total of 27 patients with brain tumors were examined in 1,5T MRI. Single phase and multiphase ASL, DSCE-CBV examinations were assessed by both qualitative and quantitative analysis for the detection of malignancy. Imaging results were correlated with a histopathology or follow-up.
  
  
  RESULTS
  Based on 31 studies in 27 patients with brain tumors, the visual inspection sensitivities for ASL and dynamic DSC perfusion imaging were 88% and 94%, respectively, with 100% specificity for both. On qualitative evaluation, sensitivities for ASL and DSC perfusion imaging perfusions were 88% and 94%, respectively, with 100% specificity for both. The highest sensitivity values for quantitative ASL imaging were obtained using a normalized cut-off ratio of 1.65, resulting in sensitivity of 94% for ASL imaging and cut-off ratio of 1.95 and sensitivity 94% for DSCE-CBV imaging.
  
  
  CONCLUSIONS
  The present study revealed similar sensitivity and specificity for both multhiphase ASL and DSC MRI. Thus, we suggest that ASL perfusion can be used in daily clinical practice.
authors: Department of Radiology, Adnan Menderes University Faculty of Medicine, 09010, Aydın, Turkey; Department of Radiology, Usak State Hospital, 33940, Uşak, Turkey. Electronic address: e.s.ata@hotmail.com.
authors: Emine Sevcan
authors: ES
authors: Ata
authors: Department of Neurosurgery, Adnan Menderes University Faculty of Medicine, 09010, Aydın, Turkey. Electronic address: drmturgut@yahoo.com.
authors: Mehmet
authors: M
authors: Turgut
authors: Department of Radiology, Adnan Menderes University Faculty of Medicine, 09010, Aydın, Turkey; Department of Radiology, Ege University Faculty of Medicine, 35100, Bornova, Izmir, Turkey. Electronic address: eraslancenk@hotmail.com.
authors: Cenk
authors: C
authors: Eraslan
authors: Department of Radiology, Adnan Menderes University Faculty of Medicine, 09010, Aydın, Turkey. Electronic address: yeldaozsunar@gmail.com.
authors: Yelda Özsunar
authors: YÖ
authors: Dayanır
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001810:Blood Volume; D001921:Brain / Q000000981:diagnostic imaging / Q000503:physiopathology; D001932:Brain Neoplasms / Q000000981:diagnostic imaging* / Q000503:physiopathology; D003287:Contrast Media; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D013113:Spin Labels; D055815:Young Adult
chemical_list: D003287:Contrast Media; D013113:Spin Labels
keywords: Arterial spin labeling; Brain tumors; Magnetic resonance imaging