title: Perinatal BPA exposure alters body weight and composition in a dose specific and sex specific manner: The addition of peripubertal exposure exacerbates adverse effects in female mice.
abstract: Body weight (BW) and body composition were examined in CD-1 mice exposed perinatally or perinatally and peripubertally to 0, 0.25, 2.5, 25, or 250μg BPA/kg BW/day. Our goal was to identify the BPA dose (s) and the exposure window(s) that increased BW and adiposity, and to assess potential sex differences in this response. Both perinatal exposure alone and perinatal plus peripubertal exposure to environmentally relevant levels of BPA resulted in lasting effects on body weight and body composition. The effects were dose specific and sex specific and were influenced by the precise window of BPA exposure. The addition of peripubertal BPA exposure following the initial perinatal exposure exacerbated adverse effects in the females but appeared to reduce differences in body weight and body composition between control and BPA exposed males. Some effects of BPA on body weight and body composition showed a non-linear dose response.
authors: Department of Integrated Physiology and Pathobiology, Tufts University School of Medicine, Sackler School of Biomedical Sciences, Boston, MA 02111, United States. Electronic address: Beverly.rubin@tufts.edu.
authors: Beverly S
authors: BS
authors: Rubin
authors: Department of Integrated Physiology and Pathobiology, Tufts University School of Medicine, Sackler School of Biomedical Sciences, Boston, MA 02111, United States.
authors: Maneesha
authors: M
authors: Paranjpe
authors: Department of Integrated Physiology and Pathobiology, Tufts University School of Medicine, Sackler School of Biomedical Sciences, Boston, MA 02111, United States.
authors: Tracey
authors: T
authors: DaFonte
authors: Department of Integrated Physiology and Pathobiology, Tufts University School of Medicine, Sackler School of Biomedical Sciences, Boston, MA 02111, United States.
authors: Cheryl
authors: C
authors: Schaeberle
authors: Department of Integrated Physiology and Pathobiology, Tufts University School of Medicine, Sackler School of Biomedical Sciences, Boston, MA 02111, United States.
authors: Ana M
authors: AM
authors: Soto
authors: Nutrition and Genomics Lab., Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, United States.
authors: Martin
authors: M
authors: Obin
authors: Obesity and Metabolism Lab., Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, United States.
authors: Andrew S
authors: AS
authors: Greenberg
mesh_terms: D000375:Aging / Q000187:drug effects* / Q000378:metabolism; D000818:Animals; D001559:Benzhydryl Compounds / Q000097:blood / Q000633:toxicity*; D001823:Body Composition / Q000187:drug effects*; D001835:Body Weight / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D004785:Environmental Pollutants / Q000097:blood / Q000633:toxicity*; D005260:Female; D008297:Male; D051379:Mice; D010636:Phenols / Q000097:blood / Q000633:toxicity*; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000139:chemically induced* / Q000378:metabolism; D012737:Sex Factors; D000098826:Bisphenol A Compounds
chemical_list: D001559:Benzhydryl Compounds; D004785:Environmental Pollutants; D010636:Phenols; C006780:bisphenol A; D000098826:Bisphenol A Compounds
keywords: Bisphenol A (BPA); Body composition; Developmental origins of adult disease; Extreme hyperactivity; Non-monotonic dose response; Obesity; Sex differences