title: Frequency of twelve carcinogenic human papilloma virus types among women from the South Backa region, Vojvodina, Serbia.
abstract: OBJECTIVE
  The aim of this study was to determine the presence and age distribution of different oncogenic human papilloma virus (HPV) types in women in the South Backa region and its relationship to Pap results.
  
  
  METHODS
  In a group of 1087 women with normal and abnormal cytology, the commercial HR HPV Real-TM kit (Sacace Biotechnologies, Italy) was used.
  
  
  RESULTS
  Overall, 50.5% of the women were HPV positive. The presence of HPV types 18, 31, 51, and 58 was significantly influenced by age, while the presence of HPV types 16 and 45 was significantly influenced by cervical cytology. Results of the LSD test show a wide spectrum of high risk HPV among women with normal cytology and women with a low grade cervical lesion rate (atypical squamous cell of undetermined significance (ASCUS) and low grade squamous intraepithelial lesions (LSIL). The most prevalent HPV types found were 16, 31, 51, 18, and 52. In the HSIL group the most prevalent HPV types were 16 and 45.
  
  
  CONCLUSIONS
  The reported results provide new data on the circulation of oncogenic HPV genotypes and frequency of multiple infections among women in Vojvodina and suggest that a prophylactic vaccine against HPV 16 and 18 has the potential to prevent approximately half of the high-grade lesions.
authors: Institute for Public Health of Vojvodina, Novi Sad, Serbia.
authors: Gordana
authors: G
authors: Kovacevic
authors: Institute for Public Health of Vojvodina, Novi Sad, Serbia.
authors: Natasa
authors: N
authors: Nikolic
authors: Institute for Public Health of Vojvodina, Novi Sad, Serbia.
authors: Aleksandra
authors: A
authors: Jovanovic-Galovic
authors: Faculty of Medicine, University of Novi Sad, Serbia.
authors: Iv
authors: I
authors: Hrnjakovic-Cvjetkovic
authors: Clinical Center of Vojvodina, Department of Obstetrics and Gynecology, Novi Sad, Serbia.
authors: Dusan
authors: D
authors: Vuleta
authors: Faculty of Medicine, University of Novi Sad, Serbia.
authors: Aleksandra
authors: A
authors: Patic
authors: Institute for Public Health of Vojvodina, Novi Sad, Serbia.
authors: Jelena
authors: J
authors: Radovanov
authors: Faculty of Medicine, University of Novi Sad, Serbia.
authors: Vesna
authors: V
authors: Milosevic
mesh_terms: D005260:Female; D006801:Humans; D027383:Papillomaviridae; D030361:Papillomavirus Infections; D055771:Serbia; D002583:Uterine Cervical Neoplasms; D015022:Yugoslavia; D002578:Uterine Cervical Dysplasia
keywords: Human papilloma virus; cervical cytology; real-time PCR