title: Cucurbit[8]uril Regulated Activatable Supramolecular Photosensitizer for Targeted Cancer Imaging and Photodynamic Therapy.
abstract: Activatable photosensitizers (aPSs) have emerged as promising photodynamic therapy (PDT) agents for simultaneous imaging and selective ablation of cancer. However, traditional synthetic aPSs are limited by complex design and tedious synthesis. Here, aPS regulated by cucurbit[8]uril (CB[8]) for targeted cancer imaging and PDT is reported. This system is based on the host-guest interaction between biotinylated toluidine blue (TB-B) and CB[8] to form 2TB-B@CB[8]. Moreover, a facile strategy to turn off/on the fluorescence and photodynamic activity of TB-B is developed through the reversible assembly/disassembly of 2TB-B@CB[8]. This established system can achieve selective accumulation in tumor, light-up cancer imaging, and enhanced anticancer behavior. Therefore, this work provides a novel and promising strategy for the aPS build via simple and facile regulation of supramolecular chemistry.
authors: Key Laboratory of Biomedical Polymers of Ministry of Education, Institute for Advanced Studies & Department of Chemistry, Wuhan University , Wuhan 430072, P.R. China.
authors: Xiao-Qiang
authors: XQ
authors: Wang
authors: Key Laboratory of Biomedical Polymers of Ministry of Education, Institute for Advanced Studies & Department of Chemistry, Wuhan University , Wuhan 430072, P.R. China.
authors: Qi
authors: Q
authors: Lei
authors: Key Laboratory of Biomedical Polymers of Ministry of Education, Institute for Advanced Studies & Department of Chemistry, Wuhan University , Wuhan 430072, P.R. China.
authors: Jing-Yi
authors: JY
authors: Zhu
authors: Key Laboratory of Biomedical Polymers of Ministry of Education, Institute for Advanced Studies & Department of Chemistry, Wuhan University , Wuhan 430072, P.R. China.
authors: Wen-Jing
authors: WJ
authors: Wang
authors: Key Laboratory of Biomedical Polymers of Ministry of Education, Institute for Advanced Studies & Department of Chemistry, Wuhan University , Wuhan 430072, P.R. China.
authors: Qian
authors: Q
authors: Cheng
authors: Key Laboratory of Biomedical Polymers of Ministry of Education, Institute for Advanced Studies & Department of Chemistry, Wuhan University , Wuhan 430072, P.R. China.
authors: Fan
authors: F
authors: Gao
authors: Key Laboratory of Biomedical Polymers of Ministry of Education, Institute for Advanced Studies & Department of Chemistry, Wuhan University , Wuhan 430072, P.R. China.
authors: Yun-Xia
authors: YX
authors: Sun
authors: Key Laboratory of Biomedical Polymers of Ministry of Education, Institute for Advanced Studies & Department of Chemistry, Wuhan University , Wuhan 430072, P.R. China.
authors: Xian-Zheng
authors: XZ
authors: Zhang
mesh_terms: D001952:Bridged-Ring Compounds; D005453:Fluorescence; D007093:Imidazoles; D009369:Neoplasms; D010778:Photochemotherapy; D017319:Photosensitizing Agents / Q000737:chemistry*; D047028:Macrocyclic Compounds; D000099246:Cucurbit(n)urils
chemical_list: D001952:Bridged-Ring Compounds; D007093:Imidazoles; D017319:Photosensitizing Agents; C507198:cucurbit(8)uril; D047028:Macrocyclic Compounds; D000099246:Cucurbit(n)urils
keywords: activatable photosensitizer; anticancer; photodynamic therapy; singlet oxygen; supramolecular chemistry