title: Durotaxis in Nematode Caenorhabditis elegans.
abstract: Durotaxis is a process where cells are able to sense the stiffness of substrates and preferentially migrate toward stiffer regions. Here, we show that the 1-mm-long nematode, Caenorhabditis elegans are also able to detect the rigidity of underlying substrates and always migrate to regions of higher stiffness. Our results indicate that C. elegans are able to judiciously make a decision to stay on stiffer regions. We found that the, undulation frequency, and wavelength of worms, crawling on surfaces show nonmonotonic behavior with increasing stiffness. A number of control experiments were also conducted to verify whether C. elegans are really able to detect the rigidity of substrates or whether the migration to stiffer regions is due to other factors already reported in the literature. As it is known that bacteria and other single-celled organisms exhibit durotaxis toward stiffer surfaces, we conjecture that durotaxis in C. elegans may be one of the strategies developed to improve their chances of locating food.
authors: Department of Chemical Engineering, Indian Institute of Technology, Kharagpur, West Bengal, India.
authors: Lipika
authors: L
authors: Parida
authors: Department of Chemical Engineering, Indian Institute of Technology, Kharagpur, West Bengal, India. Electronic address: venkatp@che.iitkgp.ernet.in.
authors: Venkat
authors: V
authors: Padmanabhan
mesh_terms: D000818:Animals; D001696:Biomechanical Phenomena; D017173:Caenorhabditis elegans / Q000166:cytology*; D002633:Chemotaxis; D055595:Mechanical Phenomena