title: Tuning the Drug Loading and Release of DNA-Assembled Gold-Nanorod Superstructures.
abstract: The use of DNA to assemble inorganic nanoparticles into superstructures is an emerging strategy to build non-toxic delivery vehicles for targeting diseases in the body. The impact of the core-satellite nanosystem design in mediating drug storage, drug release (via heat), and killing of HeLa cells in culture is investigated.
authors: Department of Material Science and Engineering, University of Toronto, Toronto, M5S 3E1, Canada.|Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, Ontario, M5S 3G9, Canada.
authors: Vahid
authors: V
authors: Raeesi
authors: Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, Ontario, M5S 3G9, Canada.|Dana-Farber Cancer Institute, Department of Cancer Biology, Harvard Medical School 44 Binney St., Boston, MA, 02115, USA.|Wyss Institute for Biologically Inspired Engineering, Harvard University, 3 Blackfan Circle, CLSB 5th Floor, Boston, MA, 02115, USA.
authors: Leo Y T
authors: LY
authors: Chou
authors: Department of Material Science and Engineering, University of Toronto, Toronto, M5S 3E1, Canada. warren.chan@utoronto.ca.|Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, Ontario, M5S 3G9, Canada. warren.chan@utoronto.ca.|Department of Chemical Engineering, University of Toronto, Toronto, Ontario, M5S 3E5, Canada. warren.chan@utoronto.ca.|Department of Chemistry, University of Toronto, Toronto, Ontario, M5S 3H6, Canada. warren.chan@utoronto.ca.
authors: Warren C W
authors: WC
authors: Chan
mesh_terms: D004247:DNA; D016503:Drug Delivery Systems; D006046:Gold; D006367:HeLa Cells; D006801:Humans; D053758:Nanoparticles; D043942:Nanotubes
chemical_list: D006046:Gold; D004247:DNA
keywords: DNA assembly; cancer; controlled drug release; core-satellite; gold nanorods; nanomedicine; nanotechnology