title: Integrity of Amygdala Subregion-Based Functional Networks and Emotional Lability in Drug-Naïve Boys With ADHD.
abstract: Objective:This study evaluated the functional networks of amygdala subregions (basolateral [BLA], centromedial [CMA], and superficial amygdala [SFA]) in ADHD and their association with emotional lability (EL) symptoms.Method:Resting-state functional connectivity (RSFC) of amygdala subregions and their correlations with EL scores were evaluated in 35 drug-naïve boys with ADHD and 30 age-matched healthy controls (HC).Results:Compared with HC, altered RSFC were detected differently for each amygdala subregion in ADHD: altered RSFC of BLA with the thalamus and vermis; aberrant RSFC of CMA with the superior temporal gyrus/pole and insula, precuneus and cerebellum; reduced RSFC of SFA with dorsal frontoparietal cortices. Within ADHD, higher EL scores were associated with reduced negative RSFC of SFA with the dorsolateral prefrontal cortex and inferior parietal lobe.Conclusion:Diffuse alterations of amygdala subregion-based networks are associated with ADHD, and the weaker SFA-frontoparietal networks might be involved in the hypothesized top-down effortful regulation of emotion.
authors: Peking University Sixth Hospital/Institute of Mental Health, Beijing, China.|National Clinical Research Center for Mental Disorders & Key Laboratory of Mental Health, Ministry of Health (Peking University), Beijing, China.|Joint first authors.
authors: Xiaoyan
authors: X
authors: Yu
authors: Peking University Sixth Hospital/Institute of Mental Health, Beijing, China.|National Clinical Research Center for Mental Disorders & Key Laboratory of Mental Health, Ministry of Health (Peking University), Beijing, China.|Joint first authors.
authors: Lu
authors: L
authors: Liu
authors: Centre & Discipline of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy; School of Psychiatry and Clinical Neurosciences & School of Paediatrics and Child Health, The University of Western Australia, Perth, WA, Australia.|Specialised Child and Adolescent Mental Health Services, Department of Health in Western Australia, Perth, WA, Australia.
authors: Wai
authors: W
authors: Chen
authors: Peking University Sixth Hospital/Institute of Mental Health, Beijing, China.|National Clinical Research Center for Mental Disorders & Key Laboratory of Mental Health, Ministry of Health (Peking University), Beijing, China.
authors: Qingjiu
authors: Q
authors: Cao
authors: Centre & Discipline of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy; School of Psychiatry and Clinical Neurosciences & School of Paediatrics and Child Health, The University of Western Australia, Perth, WA, Australia.|Specialised Child and Adolescent Mental Health Services, Department of Health in Western Australia, Perth, WA, Australia.
authors: Florian Daniel
authors: FD
authors: Zepf
authors: Laboratory of Cognitive Neuropsychology, Department of Medical Psychology, Anhui Medical University, Hefei, China.
authors: Gongjun
authors: G
authors: Ji
authors: Peking University Sixth Hospital/Institute of Mental Health, Beijing, China.|National Clinical Research Center for Mental Disorders & Key Laboratory of Mental Health, Ministry of Health (Peking University), Beijing, China.
authors: Zhaomin
authors: Z
authors: Wu
authors: Peking University Sixth Hospital/Institute of Mental Health, Beijing, China.|National Clinical Research Center for Mental Disorders & Key Laboratory of Mental Health, Ministry of Health (Peking University), Beijing, China.
authors: Li
authors: L
authors: An
authors: Peking University Sixth Hospital/Institute of Mental Health, Beijing, China.|National Clinical Research Center for Mental Disorders & Key Laboratory of Mental Health, Ministry of Health (Peking University), Beijing, China.
authors: Peng
authors: P
authors: Wang
authors: Peking University Sixth Hospital/Institute of Mental Health, Beijing, China.|National Clinical Research Center for Mental Disorders & Key Laboratory of Mental Health, Ministry of Health (Peking University), Beijing, China.
authors: Qiujin
authors: Q
authors: Qian
authors: Center for Cognition and Brain Disorders and the Affiliated Hospital, Hangzhou Normal University; Zhejiang Key Laboratory for Research in Assessment of Cognitive Impairments, Hangzhou, China.
authors: Yufeng
authors: Y
authors: Zang
authors: Peking University Sixth Hospital/Institute of Mental Health, Beijing, China.|National Clinical Research Center for Mental Disorders & Key Laboratory of Mental Health, Ministry of Health (Peking University), Beijing, China.
authors: Li
authors: L
authors: Sun
authors: Peking University Sixth Hospital/Institute of Mental Health, Beijing, China.|National Clinical Research Center for Mental Disorders & Key Laboratory of Mental Health, Ministry of Health (Peking University), Beijing, China.
authors: Yufeng
authors: Y
authors: Wang
mesh_terms: D000679:Amygdala / Q000000981:diagnostic imaging; D001289:Attention Deficit Disorder with Hyperactivity; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D009415:Nerve Net / Q000000981:diagnostic imaging; D004364:Pharmaceutical Preparations
chemical_list: D004364:Pharmaceutical Preparations
keywords: ADHD; amygdala subregions; dorsal prefrontal cortex; emotional lability; resting-state functional connectivity