title: Knockout of Abi3bp in mice does not affect their olfactory function, mental state and NNK-induced lung tumorigenesis.
abstract: Abi3bp was originally discovered as Abi3-Src homology 3 (SH3) binding protein and has been proved to have a broad expression profile in adult tissues. Although previous studies have indicated that Abi3bp may be associated with cancer suppression, cell senescence, dendritic refinement and mental disorder, most conclusions achieved were based on in vitro model or genome-wide association study. In this work, we constructed an Abi3bp-deficient mouse model and observed phenotypic changes. The generated Abi3bp-knockout mice are viable and fertile, develop normally and exhibit no significant differences in anxiety or depression-like behaviors, olfactory function and tumor incidence. These data suggest that the function of Abi3bp in in vitro models does not translate to a similar role in the intact animal. Its depletion may be compensated by other genes, which needs to be addressed in future studies.
authors: School of Life Science and Technology, Tongji University, Shanghai 200092, China.
authors: Hua
authors: H
authors: Yang
authors: School of Life Science and Technology, Tongji University, Shanghai 200092, China.
authors: Weidong
authors: W
authors: Chen
authors: School of Life Science and Technology, Tongji University, Shanghai 200092, China.
authors: Jiahao
authors: J
authors: Shi
authors: School of Life Science and Technology, Tongji University, Shanghai 200092, China.
authors: Dandan
authors: D
authors: Huang
authors: Shanghai Engineering Research Center of Model Organisms/Shanghai Research Center for Model Organisms, Shanghai 201203, China.
authors: Jun
authors: J
authors: Li
authors: School of Life Science and Technology, Tongji University, Shanghai 200092, China.
authors: Binyang
authors: B
authors: Hu
authors: School of Life Science and Technology, Tongji University, Shanghai 200092, China.
authors: Mengjie
authors: M
authors: Zhang
authors: Shanghai Engineering Research Center of Model Organisms/Shanghai Research Center for Model Organisms, Shanghai 201203, China.
authors: Zhugang
authors: Z
authors: Wang
authors: School of Life Science and Technology, Tongji University, Shanghai 200092, China Shanghai Engineering Research Center of Model Organisms/Shanghai Research Center for Model Organisms, Shanghai 201203, China jfei@tongji.edu.cn.
authors: Jian
authors: J
authors: Fei
mesh_terms: D000818:Animals; D001522:Behavior, Animal / Q000502:physiology; D063646:Carcinogenesis; D002352:Carrier Proteins / Q000037:antagonists & inhibitors* / Q000235:genetics / Q000502:physiology*; D008175:Lung Neoplasms / Q000209:etiology* / Q000235:genetics / Q000503:physiopathology; D008297:Male; D001523:Mental Disorders / Q000235:genetics / Q000503:physiopathology; D051379:Mice; D018345:Mice, Knockout; D009602:Nitrosamines / Q000633:toxicity; D010641:Phenotype; D012903:Smell / Q000235:genetics / Q000502:physiology*
chemical_list: D002352:Carrier Proteins; D009602:Nitrosamines; C527603:TARSH protein, mouse
keywords: Abi3bp; knockout model; mental disorder; tumorigenesis