title: Gastric Carcinoma: Recent Trends in Diagnostic Biomarkers and Molecular Targeted Therapies.
abstract: Gastric cancer is generally associated with poor survival rates and accounts for a remarkable proportion of global cancer mortality. The prevalence of gastric carcinoma varies in different regions of world and across teh various ethnic groups. On the basis of pathological assessment, gastric cancer can be categorized as intestinal and diffuse carcinomas. The etiology is diverse, including chemical carcinogen exposure, and high salt intake Helicobacter pylori also plays a vital role in the pathogenesis of certain gastric carcinomas. The development of gastric cancer involves various alterations in mRNAs, genes (GOLPH3, MTA2) and proteins (Coronins). miRNAs, Hsamir135b, MiR21, miR106b, miR17, miR18a, MiR21, miR106b, miR17, miR18a and MiRNA375, miRNA1955p are the latest diagnostic biomarkers which can facilitate the early diagnosis of gastric carcinomas. Recent development in the treatment strategies for gastric carcinoma include the introduction of monoclonal antibodies, TKI inhibitors, inhibitors of PDGFR β, VEGFR1, VEGFR2, AntiEGFR and antiHER2 agents which can be applied along with conventional therapies.
authors: Institute of Pharmacy, Physiology and Pharmacology, University of Agriculture, Faisalabad, Pakistan Email : wafamajeed@hotmail.com.
authors: Wafa
authors: W
authors: Majeed
authors: Asra
authors: A
authors: Iftikhar
authors: Tanweer
authors: T
authors: Khaliq
authors: Bilal
authors: B
authors: Aslam
authors: Humaira
authors: H
authors: Muzaffar
authors: Komal
authors: K
authors: Atta
authors: Aisha
authors: A
authors: Mahmood
authors: Shahid
authors: S
authors: Waris
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology* / Q000627:therapeutic use*; D014408:Biomarkers, Tumor / Q000378:metabolism; D002277:Carcinoma / Q000175:diagnosis* / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D055088:Early Detection of Cancer; D006801:Humans; D035683:MicroRNAs / Q000378:metabolism; D058990:Molecular Targeted Therapy / Q000379:methods; D013274:Stomach Neoplasms / Q000175:diagnosis* / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology
chemical_list: D000970:Antineoplastic Agents; D014408:Biomarkers, Tumor; D035683:MicroRNAs