title: Cribriform-morular variant of papillary thyroid carcinoma at pediatric age - case report and review of the literature.
abstract: Cribriform-morular variant of papillary thyroid carcinoma (CMV-PTC) is a rare tumor, which exceptionally occurs at pediatric age. CMV-PTC may develop in patients with familial adenomatous polyposis (FAP) or may be a sporadic tumor. The authors present a case of CMV-PTC in a 10-year-old girl patient without FAP history, who presented with a left neck mass. The patient underwent total thyroidectomy with central compartment neck dissection. Histopathological diagnosis was compatible with cribriform-morular variant of papillary thyroid carcinoma and Hashimoto's thyroiditis. Immunostaining was positive for thyroglobulin, β-catenin, CD10 and p53. Molecular test showed the absence of BRAF, K-RAS mutations, deletions or duplications of APC (adenomatosis polyposis coli) gene and showed the presence of RET÷PTC (rearranged during transfection÷papillary thyroid carcinoma) rearrangements. At 32 months follow-up, the patient was without signs of recurrence. This particular form of thyroid carcinoma should raise suspicion of a possible familial cancer syndrome, therefore early diagnosis and thoroughly evaluation, which includes colonoscopy and genetic screening are mandatory.
authors: Department of Neurosurgery, "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania; felixbrehar@yahoo.com.
authors: Andreea Cristiana
authors: AC
authors: Brehar
authors: Dana Cristina
authors: DC
authors: Terzea
authors: Dumitru Lucian
authors: DL
authors: Ioachim
authors: Camelia
authors: C
authors: Procopiuc
authors: Felix Mircea
authors: FM
authors: Brehar
authors: Alexandra Cătălina
authors: AC
authors: Bulgăr
authors: Mircea Vasile
authors: MV
authors: Ghemigian
authors: Constantin
authors: C
authors: Dumitrache
mesh_terms: D002277:Carcinoma / Q000000981:diagnostic imaging / Q000378:metabolism / Q000473:pathology*; D002291:Carcinoma, Papillary; D002648:Child; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D013954:Thyroglobulin / Q000378:metabolism; D000077273:Thyroid Cancer, Papillary; D013964:Thyroid Neoplasms / Q000000981:diagnostic imaging / Q000378:metabolism / Q000473:pathology*; D014057:Tomography, X-Ray Computed
chemical_list: D013954:Thyroglobulin