title: Development of Sensitive Analytical Approach for the Quantification of α-Lipoic Acid Using Boron Doped Diamond Electrode.
abstract: A boron doped diamond (BDD) electrode was investigated for use as an electrochemical sensor for α-lipoic acid (LA) using amperometric and differential pulse voltammetric detection. LA displays a well expressed oxidation peak at +0.9 V vs. Ag/AgCl in solutions with a pH value of 3. It was found that signals obtained are linearly related to the concentration range from 0.3 to 105 μM with detection limit of 0.088 μM. Interferences by common compounds such as ascorbic acid, uric acid and dopamine were tested and the method was successfully applied to the determination of LA in human body fluids where it gave recoveries in the range from 95 to 97%.
authors: Innovation Center of the Faculty of Chemistry, University of Belgrade.
authors: Dalibor M
authors: DM
authors: Stankovic
authors: Eda
authors: E
authors: Mehmeti
authors: Kurt
authors: K
authors: Kalcher
mesh_terms: D001895:Boron / Q000737:chemistry*; D002138:Calibration; D018130:Diamond; D004566:Electrodes; D006863:Hydrogen-Ion Concentration; D057230:Limit of Detection; D008063:Thioctic Acid / Q000032:analysis*
chemical_list: D008063:Thioctic Acid; D018130:Diamond; D001895:Boron