title: Translational Relevance of Swine Models of Spinal Cord Injury.
abstract: Spinal cord injury (SCI) is a physically and psychologically devastating clinical condition. The typical treatment regimens of decompressive surgery and rehabilitation therapy still leave many patients with permanent disability. The development of new therapies and devices can be accelerated if relevant translational animal models are more effectively used in pre-clinical stages. Swine is a highly relevant model for SCI research, especially with respect to spine and spinal cord anatomy, spine vasculature, immune responses to injury, and functional assessments. Several spine injury models have recently been developed for swine and are beginning to be used to evaluate new therapies. Swine models of SCI offer tremendous advantages for efficient translation of pre-clinical discoveries and the development of new therapies and devices. Future swine models will also be enhanced by advances in gene-editing technology to further elucidate the complex pathophysiology associated with SCI and provide a means to engineer specific spinal pathologies.
authors: 1 Biomedical and Genomic Research Group, Department of Animal Sciences, University of Wisconsin-Madison , Wisconsin.
authors: Dominic T
authors: DT
authors: Schomberg
authors: 2 Department of Neurological Surgery, University of Wisconsin School of Medicine and Public Health , Madison, Wisconsin.
authors: Gurwattan S
authors: GS
authors: Miranpuri
authors: 2 Department of Neurological Surgery, University of Wisconsin School of Medicine and Public Health , Madison, Wisconsin.
authors: Abhishek
authors: A
authors: Chopra
authors: 2 Department of Neurological Surgery, University of Wisconsin School of Medicine and Public Health , Madison, Wisconsin.
authors: Kush
authors: K
authors: Patel
authors: 1 Biomedical and Genomic Research Group, Department of Animal Sciences, University of Wisconsin-Madison , Wisconsin.
authors: Jennifer J
authors: JJ
authors: Meudt
authors: 3 Alizée Pathology, LLC , Thurmont, Maryland.
authors: Armando
authors: A
authors: Tellez
authors: 2 Department of Neurological Surgery, University of Wisconsin School of Medicine and Public Health , Madison, Wisconsin.
authors: Daniel K
authors: DK
authors: Resnick
authors: 1 Biomedical and Genomic Research Group, Department of Animal Sciences, University of Wisconsin-Madison , Wisconsin.
authors: Dhanansayan
authors: D
authors: Shanmuganayagam
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D006801:Humans; D018836:Inflammation Mediators / Q000276:immunology / Q000378:metabolism; D013119:Spinal Cord Injuries / Q000276:immunology* / Q000378:metabolism / Q000473:pathology*; D013552:Swine; D057170:Translational Research, Biomedical / Q000639:trends*
chemical_list: D018836:Inflammation Mediators
keywords: animal studies; models of injury; spinal cord injury