title: How to interpret cardiac biomarkers in renal failure and elderly?
abstract: New highly sensitive (hs) assays have challenged the interpretation of cardiac troponins (cTn) as markers of injury while natriuretic peptides remain the markers of choice for myocardial dysfunction. However, variability extracardiac factors such as age, gender and renal function may alter circulating levels. In chronic kidney disease (CKD), the increase in circulating levels of these biomarkers in the absence of cardiac disease underlines the problem of discriminative value for diagnosis as well as the need to redefine the thresholds. In addition, these biomarkers are of potential interest to stratify cardiovascular risk, the leading cause of death in CKD. The aim of this work is to clarify the effect of age and renal function on circulating levels of high-sensitivity troponins and natriuretic peptides.
authors: Département de biochimie-hormonologie, CHRU de Montpellier, PhyMedExp, University of Montpellier, Inserm U1046, CNRS UMR 9214, Montpellier, France.
authors: Anne-Sophie
authors: AS
authors: Bargnoux
authors: Département de biochimie-hormonologie, CHRU de Montpellier, PhyMedExp, University of Montpellier, Inserm U1046, CNRS UMR 9214, Montpellier, France.
authors: Nils
authors: N
authors: Kuster
authors: Département de biochimie-hormonologie, CHRU de Montpellier, PhyMedExp, University of Montpellier, Inserm U1046, CNRS UMR 9214, Montpellier, France.
authors: Marion
authors: M
authors: Moréna
authors: Département de médecine interne et gériatrie, CHRU de Montpellier, PhyMedExp, University of Montpellier, Inserm U1046, CNRS UMR 9214, Montpellier, France.
authors: Gregory
authors: G
authors: Baptista
authors: Département de néphrologie, CHRU Montpellier, Université de Montpellier 1, Montpellier, France.
authors: Leila
authors: L
authors: Chenine
authors: Département de biochimie-hormonologie, CHRU de Montpellier, PhyMedExp, University of Montpellier, Inserm U1046, CNRS UMR 9214, Montpellier, France.
authors: Stéphanie
authors: S
authors: Badiou
authors: Département de néphrologie, CHRU Montpellier, Université de Montpellier 1, Montpellier, France.
authors: Hélène
authors: H
authors: Leray
authors: Département de biochimie-hormonologie, CHRU Montpellier, Université de Montpellier 1, Montpellier, France.
authors: Anne-Marie
authors: AM
authors: Dupuy
authors: Département de biochimie-hormonologie, CHRU de Montpellier, PhyMedExp, University of Montpellier, Inserm U1046, CNRS UMR 9214, Montpellier, France.
authors: Jean-Paul
authors: JP
authors: Cristol
mesh_terms: D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000378:metabolism*; D006321:Heart / Q000503:physiopathology; D006801:Humans; D009203:Myocardial Infarction / Q000175:diagnosis; D009206:Myocardium / Q000378:metabolism*; D051437:Renal Insufficiency / Q000175:diagnosis / Q000378:metabolism* / Q000503:physiopathology; D019210:Troponin I / Q000378:metabolism; D020107:Troponin T / Q000378:metabolism
chemical_list: D015415:Biomarkers; D019210:Troponin I; D020107:Troponin T
keywords: chronic kidney disease; diagnosis; high-sensitivity troponins; natriuretic peptides; prognosis