title: The selectivity of Marinopyrrole A to induce apoptosis in MCL1highBCL2lowexpressing myeloma cells is related to its ability to impair protein translation.
authors: CRCNA, CNRS, INSERM, Centre Hospitalier Universitaire de Nantes, Université d'Angers, Université de Nantes, Nantes, France.
authors: Patricia
authors: P
authors: Gomez-Bougie
authors: CRCNA, CNRS, INSERM, Centre Hospitalier Universitaire de Nantes, Université d'Angers, Université de Nantes, Nantes, France.
authors: Christelle
authors: C
authors: Dousset
authors: CRCNA, CNRS, INSERM, Centre Hospitalier Universitaire de Nantes, Université d'Angers, Université de Nantes, Nantes, France.
authors: Geraldine
authors: G
authors: Descamps
authors: CRCNA, CNRS, INSERM, Centre Hospitalier Universitaire de Nantes, Université d'Angers, Université de Nantes, Nantes, France.
authors: Anne
authors: A
authors: Schnitzler
authors: UMR_6230, CHEM-Symbiose, Nantes, France.
authors: Logan
authors: L
authors: Audiger
authors: UMR_6230, CHEM-Symbiose, Nantes, France.
authors: Arnaud
authors: A
authors: Tessier
authors: UMR_6230, CHEM-Symbiose, Nantes, France.
authors: Didier
authors: D
authors: Dubreuil
authors: UMR_6230, CHEM-Symbiose, Nantes, France.
authors: Jacques
authors: J
authors: Lebreton
authors: CRCNA, CNRS, INSERM, Centre Hospitalier Universitaire de Nantes, Université d'Angers, Université de Nantes, Nantes, France.
authors: Catherine
authors: C
authors: Pellat-Deceunynck
authors: CRCNA, CNRS, INSERM, Centre Hospitalier Universitaire de Nantes, Université d'Angers, Université de Nantes, Nantes, France.
authors: Martine
authors: M
authors: Amiot
mesh_terms: D017209:Apoptosis / Q000187:drug effects* / Q000235:genetics; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects / Q000235:genetics; D015870:Gene Expression; D006801:Humans; D009101:Multiple Myeloma / Q000235:genetics / Q000378:metabolism*; D064549:Myeloid Cell Leukemia Sequence 1 Protein / Q000235:genetics / Q000378:metabolism*; D014176:Protein Biosynthesis / Q000187:drug effects*; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000235:genetics / Q000378:metabolism*; D011758:Pyrroles / Q000494:pharmacology*
chemical_list: D064549:Myeloid Cell Leukemia Sequence 1 Protein; D019253:Proto-Oncogene Proteins c-bcl-2; D011758:Pyrroles; C528298:marinopyrrole A
keywords: BCL2 family members; MCL1; apoptosis; myeloma; translation