title: ANTI-INFLAMMATORY, ANALGESIC AND ANTIPYRETIC ACTIVITIES OF THE AQUEOUS METHANOLIC EXTRACT OF BERBERIS CALLIOBOTRYS IN ALBINO MICE.
abstract: The aqueous methanolic extract of stem part of Berberis calliobotiys (AMEBC) was evaluated for anti-inflammatory, analgesic and antipyretic activities in albino mice. Anti-inflammatory activity was evaluated by using carrageenan and albumin induced paw edema, while the analgesic effect was assessed by using formalin-induced paw licking and acetic acid induced abdominal writhing in mice. The brewer's yeast-induced pyrexia model was used for antipyretic investigation. Ibuprofen (40 mg/kg) was used as a standard drug in all the three models. The aqueous methanolic extract at both (250 mg/kg and 500 mg/kg) doses, showed highly significant (p < 0.001) reduction in paw edema induced by carrageenan and albumin. Moreover, the aqueous methanolic extract also highly significantly (p < 0.001) reduced (87%) the formalin-induced paw licking at 500 mg/kg. The highly significant (p < 0.001) reductions (24.48% and 37.9%) was also observed in the number of writhings. Furthermore, aqueous methanolic extract also demonstrated significant (p < 0.001) antipyretic activity against yeast induced pyrexia. The maximum effect was observed in all the three parameters at 500 mg/kg dose. The results suggest a potential benefit of the aqueous methanolic extract of Berbeis calliobotrys in treating conditions associated with inflammation, pain and fever.
authors: Alamgeer
authors: Huma
authors: H
authors: Naz
authors: Shadid
authors: S
authors: Rasool
authors: Sayed Atif
authors: SA
authors: Raza
authors: Taseer
authors: T
authors: Ahmad
authors: Haseeb
authors: H
authors: Ahsan
authors: Muhammad Naveed
authors: MN
authors: Mushtaq
authors: Hira
authors: H
authors: Asif
authors: Zahid
authors: Z
authors: Khan
authors: Nabeela
authors: N
authors: Noor
authors: Ambreen Malik
authors: AM
authors: Utra
authors: Umme-Habiba-Hassan
mesh_terms: D018712:Analgesics, Non-Narcotic / Q000494:pharmacology*; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D058633:Antipyretics / Q000494:pharmacology*; D028142:Berberis / Q000737:chemistry*; D005260:Female; D008297:Male; D051379:Mice; D010146:Pain / Q000139:chemically induced / Q000517:prevention & control; D010147:Pain Measurement / Q000187:drug effects; D010936:Plant Extracts / Q000494:pharmacology*
chemical_list: D018712:Analgesics, Non-Narcotic; D000894:Anti-Inflammatory Agents, Non-Steroidal; D058633:Antipyretics; D010936:Plant Extracts