title: Effect of Cellulose Acetate Beads on Interleukin-23 Release.
abstract: Interleukin (IL)-23, which is released by activated monocytes and neutrophils, promotes production of high levels of IL-17 by T-helper 17 cells. Cellulose acetate (CA) beads are used as carriers for granulocyte and monocyte (GM) adsorptive apheresis using Adacolumn. Contact between blood and CA beads induces cytokine release; however, their inflammatory effects on IL-23 release are unclear. We aimed to clarify the effect of CA beads on IL-23 release in vitro. We incubated peripheral blood with and without CA beads and measured IL-23. Compared to blood samples incubated without CA beads, blood samples incubated with CA beads had significantly decreased amounts of IL-23. In conclusion, CA beads inhibited IL-23 release from adsorbed GMs. The biological effects of this decrease in IL-23 release during GM adsorption to CA beads need further clarification.
authors: Department of Gastroenterology, Yamagata University Faculty of Medicine, Yamagata, Japan.
authors: Shoichi
authors: S
authors: Nishise
authors: Department of Gastroenterology, Yamagata University Faculty of Medicine, Yamagata, Japan.
authors: Yasuhiko
authors: Y
authors: Abe
authors: Department of Gastroenterology, Sendai City Hospital, Sendai, Japan.
authors: Eiki
authors: E
authors: Nomura
authors: Department of Gastroenterology, Yamagata University Faculty of Medicine, Yamagata, Japan.
authors: Takeshi
authors: T
authors: Sato
authors: Department of Gastroenterology, Yamagata University Faculty of Medicine, Yamagata, Japan.
authors: Yu
authors: Y
authors: Sasaki
authors: Department of Gastroenterology, Yamagata University Faculty of Medicine, Yamagata, Japan.
authors: Daisuke
authors: D
authors: Iwano
authors: Department of Gastroenterology, Yamagata University Faculty of Medicine, Yamagata, Japan.
authors: Kazuya
authors: K
authors: Yoshizawa
authors: Department of Gastroenterology, Yamagata University Faculty of Medicine, Yamagata, Japan.
authors: Makoto
authors: M
authors: Yagi
authors: Department of Gastroenterology, Yamagata University Faculty of Medicine, Yamagata, Japan.
authors: Kazuhiro
authors: K
authors: Sakuta
authors: Department of Gastroenterology, Yamagata University Faculty of Medicine, Yamagata, Japan.
authors: Yoshiyuki
authors: Y
authors: Ueno
mesh_terms: D001781:Blood Component Removal / Q000379:methods*; D002482:Cellulose / Q000031:analogs & derivatives* / Q000494:pharmacology; D006801:Humans; D066298:In Vitro Techniques; D053759:Interleukin-23 / Q000097:blood / Q000378:metabolism*
chemical_list: D053759:Interleukin-23; C005062:acetylcellulose; D002482:Cellulose
keywords: Adsorption; Cellulose acetate; Granulocyte and monocyte; Inflammatory bowel disease; Interleukin-23