title: Radio-protective effect of some new curcumin analogues.
abstract: In the present study, novel symmetrical curcumin analogues (2-7) have been synthesized by substituting the phenolic OH of curcumin with different linkers providing additional keto-enol tautomerism, very essential for radioprotective activity. The structures of the synthesized compounds (2-7) were elucidated by elemental analysis, IR, (1)H-NMR, (13)C-NMR and mass spectral data and were found consistent with the assigned structures. The curative effect of these new compounds, against the oxidative stress due to exposure of rats to the whole body γ-irradiation (7Gy) was investigated. Gamma-irradiated rats exhibited elevations of ALT, AST activities, urea, creatinine, triglycerides, total cholesterol, malondialdehyde (MDA), nitric oxide (NO), Interleukin-6 (IL-6), Tumor Necrosis Factor-α (TNF-α) and Nuclear Factor-kappa B (NF-κB) levels. Contrariwise, the total protein, albumin, total calcium level, SOD, CAT, GSH-Px, GST activities and GSH content were decreased. Treatment of gamma-irradiated rats with the new curcumin analogues (2-7) showed significant amelioration in the in-vivo antioxidant status, liver and kidney functions, as well as the anti-inflammatory markers (IL-6, TNF-α and NF-κB). Inhibition of NF-κB could be responsible for the improvement of the antioxidant and anti-inflammatory status in gamma-irradiated animals, by down-regulation of IL-1β and TNF-α level. In conclusion, the new curcumin analogues (2-7) exhibited post-protective effect on gamma-irradiation, by NF-κB inhibition.
authors: Drug Radiation Research Department, National Center for Radiation Research & Technology (NCRRT), Egyptian Atomic Energy Authority (EAEA), 3 Ahmed El-Zomor St., P.O. Box: 29, Nasr City, Cairo, Egypt. Electronic address: marwa.galal@eaea.org.eg.
authors: Marwa G
authors: MG
authors: El-Gazzar
authors: Drug Radiation Research Department, National Center for Radiation Research & Technology (NCRRT), Egyptian Atomic Energy Authority (EAEA), 3 Ahmed El-Zomor St., P.O. Box: 29, Nasr City, Cairo, Egypt.
authors: Nashwa H
authors: NH
authors: Zaher
authors: Drug Radiation Research Department, National Center for Radiation Research & Technology (NCRRT), Egyptian Atomic Energy Authority (EAEA), 3 Ahmed El-Zomor St., P.O. Box: 29, Nasr City, Cairo, Egypt.
authors: Ebaa M
authors: EM
authors: El-Hossary
authors: Drug Radiation Research Department, National Center for Radiation Research & Technology (NCRRT), Egyptian Atomic Energy Authority (EAEA), 3 Ahmed El-Zomor St., P.O. Box: 29, Nasr City, Cairo, Egypt.
authors: Amel F M
authors: AFM
authors: Ismail
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000378:metabolism; D015415:Biomarkers / Q000097:blood; D002374:Catalase / Q000378:metabolism; D002784:Cholesterol / Q000097:blood; D003474:Curcumin / Q000031:analogs & derivatives / Q000138:chemical synthesis / Q000494:pharmacology*; D015536:Down-Regulation / Q000187:drug effects* / Q000528:radiation effects; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005720:Gamma Rays; D005979:Glutathione Peroxidase / Q000378:metabolism; D015850:Interleukin-6 / Q000097:blood; D009682:Magnetic Resonance Spectroscopy; D008315:Malondialdehyde / Q000097:blood; D016328:NF-kappa B / Q000097:blood; D018384:Oxidative Stress / Q000187:drug effects* / Q000528:radiation effects; D011837:Radiation-Protective Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D013055:Spectrophotometry, Infrared; D013482:Superoxide Dismutase / Q000378:metabolism; D014409:Tumor Necrosis Factor-alpha / Q000097:blood
chemical_list: D000975:Antioxidants; D015415:Biomarkers; D015850:Interleukin-6; D016328:NF-kappa B; D011837:Radiation-Protective Agents; D014409:Tumor Necrosis Factor-alpha; D008315:Malondialdehyde; D002784:Cholesterol; D002374:Catalase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D003474:Curcumin
keywords: Anti-inflammatory; Antioxidant; Curcumin; Gamma radiation; Nuclear Factor-kappa B; Radio-protective