title: Au-Pd/reduced graphene oxide composite as a new sensing layer for electrochemical determination of ascorbic acid, acetaminophen and tyrosine.
abstract: An Au-Pd/reduced graphene oxide composite was employed as a novel electrode material for the sensitive and simultaneous determination of ascorbic acid, acetaminophen and tyrosine. The electrochemical response characteristics of the modified electrode toward the analytes were investigated by differential pulse voltammetry and cyclic voltammetry. The responses of the electrochemical sensor for the target analytes were found to be improved significantly in comparison with those obtained using a conventional carbon paste electrode (CPE) and reduced graphene oxide/CPE. The experimental conditions for simultaneous determination of these species have been established. Ternary mixtures of analytes can be determined in the ranges of 0.03-9.50μM. Under optimal conditions, the limits of detection were 15.7, 7.6 and 11.1nM for ascorbic acid, acetaminophen, and tyrosine, respectively. The method was applied successfully to determine the analytes in urine, serum and pharmaceutical samples simultaneously.
authors: Department of Chemistry, Islamic Azad University, North Tehran Branch, Tehran, Iran. Electronic address: f_tadayon@iau-tnb.ac.ir.
authors: Fariba
authors: F
authors: Tadayon
authors: Department of Chemistry, Islamic Azad University, North Tehran Branch, Tehran, Iran.
authors: Saba
authors: S
authors: Vahed
authors: Chemical Injuries Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran.
authors: Hasan
authors: H
authors: Bagheri
mesh_terms: D000082:Acetaminophen / Q000032:analysis*; D001205:Ascorbic Acid / Q000032:analysis*; D004566:Electrodes; D006046:Gold / Q000737:chemistry*; D006108:Graphite / Q000737:chemistry*; D010165:Palladium / Q000737:chemistry*; D014443:Tyrosine / Q000032:analysis*
chemical_list: D000082:Acetaminophen; D014443:Tyrosine; D010165:Palladium; D006046:Gold; D006108:Graphite; D001205:Ascorbic Acid
keywords: Au-Pd/reduced graphene oxide; Electrochemical sensors; Modified electrode; Nanocomposite; Pharmaceutical determination