title: Zinc Supplementation in Treatment of Children With Urinary Tract Infection.
abstract: BACKGROUND
  Urinary tract infection (UTI) is very common in children. Precocious diagnosis and appropriate treatment are important because of the permanent disease complications. Zinc increases the response to treatment in many infections. In this study, we explored the effect of zinc in treating UTI.
  
  
  METHODS
  Two hundred children with UTI were divided into 2 groups of 100 who were comparable in terms of age, sex, urine laboratory profiles, and clinical signs and symptoms. The control group received a standard treatment protocol for UTI and the intervention group received oral zinc sulfate syrup plus routine treatment of UTI.
  
  
  RESULTS
  A faster recovery was observed in the patients receiving zinc, but abdominal pain was exacerbated by zinc and lasted longer. Three months after the treatment, there was no significant difference between the two groups in the time of fever stop and negative urine culture.
  
  
  CONCLUSIONS
  In children with UTI, zinc supplementation has a positive effect in ameliorating severe dysuria and urinary frequency while the use of this medication is not recommended in the presence of abdominal pain.
authors: Parsa
authors: P
authors: Yousefichaijan
authors: Department of Basic Sciences, Arak University of Medical Sciences, Arak, Iran. nazirimahdyieh@yahoo.com.
authors: Mahdyieh
authors: M
authors: Naziri
authors: Hassan
authors: H
authors: Taherahmadi
authors: Manijeh
authors: M
authors: Kahbazi
authors: Aram
authors: A
authors: Tabaei
mesh_terms: D015746:Abdominal Pain; D001252:Astringents / Q000008:administration & dosage* / Q000009:adverse effects; D002648:Child; D002675:Child, Preschool; D005260:Female; D005334:Fever / Q000209:etiology; D006801:Humans; D008297:Male; D013997:Time Factors; D016896:Treatment Outcome; D016482:Urinalysis; D014552:Urinary Tract Infections / Q000188:drug therapy*; D015032:Zinc; D019287:Zinc Sulfate / Q000008:administration & dosage* / Q000009:adverse effects
chemical_list: D001252:Astringents; D019287:Zinc Sulfate; D015032:Zinc