title: Bisphenol S Interacts with Catalase and Induces Oxidative Stress in Mouse Liver and Renal Cells.
abstract: Bisphenol S (BPS) is present in multitudinous consumer products and detected in both food and water. It also has been a main substitute for bisphenol A (BPA) in the food-packaging industry. Yet, the toxicity of BPS is not fully understood. The present study of the toxicity of BPS was divided into two parts. First, oxidative stress, cell viability, apoptosis level, and catalase (CAT) activity in mouse hepatocytes and renal cells were investigated after BPS exposure. After 12 h of incubation with BPS, all of these parameters of hepatocytes and renal cells changed by >15% as the concentration of BPS ranged from 0.1 to 1 mM. Second, the direct interaction between BPS and CAT on the molecule level was investigated by multiple spectral methods and molecular docking investigations. BPS changed the structure and the activity of CAT through binding to the Gly 117 residue on the substrate channel of the enzyme. The main binding forces were hydrogen bond and hydrophobic force.
authors: School of Environmental Science and Engineering, Shandong University, China-America CRC for Environment & Health, Shandong Province , 27# Shanda South Road, Jinan 250100, People's Republic of China.
authors: Rui
authors: R
authors: Zhang
authors: School of Environmental Science and Engineering, Shandong University, China-America CRC for Environment & Health, Shandong Province , 27# Shanda South Road, Jinan 250100, People's Republic of China.
authors: Rutao
authors: R
authors: Liu
authors: College of Population, Resources and Environment, Shandong Normal University , 88# East Wenhua Road, Jinan 250014, People's Republic of China.
authors: Wansong
authors: W
authors: Zong
mesh_terms: D020816:Amino Acid Motifs; D000818:Animals; D001559:Benzhydryl Compounds / Q000737:chemistry* / Q000378:metabolism; D002374:Catalase / Q000737:chemistry* / Q000378:metabolism*; D002470:Cell Survival; D002478:Cells, Cultured; D052244:Endocrine Disruptors / Q000737:chemistry* / Q000378:metabolism; D022781:Hepatocytes / Q000166:cytology / Q000378:metabolism; D007668:Kidney / Q000166:cytology* / Q000378:metabolism; D008099:Liver / Q000166:cytology / Q000378:metabolism; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D062105:Molecular Docking Simulation; D018384:Oxidative Stress; D010636:Phenols / Q000737:chemistry* / Q000378:metabolism; D011485:Protein Binding; D000098826:Bisphenol A Compounds
chemical_list: D001559:Benzhydryl Compounds; D002374:Catalase; D052244:Endocrine Disruptors; D010636:Phenols; C006780:bisphenol A; D000098826:Bisphenol A Compounds
keywords: bisphenol S; catalase; hepatocyte; oxidative stress; renal cell; spectroscopy