title: Role of bone marrow macrophages in controlling homeostasis and repair in bone and bone marrow niches.
abstract: Macrophages, named for their phagocytic ability, participate in homeostasis, tissue regeneration and inflammatory responses. Bone and adjacent marrow contain multiple functionally unique resident tissue macrophage subsets which maintain and regulate anatomically distinct niche environments within these interconnected tissues. Three subsets of bone-bone marrow resident tissue macrophages have been characterised; erythroblastic island macrophages, haematopoietic stem cell niche macrophages and osteal macrophages. The role of these macrophages in controlling homeostasis and repair in bone and bone marrow niches is reviewed in detail.
authors: Blood and Bone Diseases Program, Mater Research Institute - The University of Queensland, Faculty of Medicine and Biomedical Sciences, Translational Research Institute, 37 Kent Street, Woolloongabba, 4102, Australia. Electronic address: simranpreet.Kaur@mater.uq.edu.au.
authors: Simranpreet
authors: S
authors: Kaur
authors: Blood and Bone Diseases Program, Mater Research Institute - The University of Queensland, Faculty of Medicine and Biomedical Sciences, Translational Research Institute, 37 Kent Street, Woolloongabba, 4102, Australia. Electronic address: liza-jane.raggatt@mater.uq.edu.au.
authors: Liza Jane
authors: LJ
authors: Raggatt
authors: Blood and Bone Diseases Program, Mater Research Institute - The University of Queensland, Faculty of Medicine and Biomedical Sciences, Translational Research Institute, 37 Kent Street, Woolloongabba, 4102, Australia. Electronic address: lena.batoon@mater.uq.edu.au.
authors: Lena
authors: L
authors: Batoon
authors: The Roslin Institute and Royal (Dick) School of Veterinary Studies, The University of Edinburgh, Roslin, Midlothian EH25 9PS, Scotland, United Kingdom. Electronic address: david.hume@roslin.ed.ac.uk.
authors: David Arthur
authors: DA
authors: Hume
authors: Blood and Bone Diseases Program, Mater Research Institute - The University of Queensland, Faculty of Medicine and Biomedical Sciences, Translational Research Institute, 37 Kent Street, Woolloongabba, 4102, Australia. Electronic address: jp.levesque@mater.uq.edu.au.
authors: Jean-Pierre
authors: JP
authors: Levesque
authors: Blood and Bone Diseases Program, Mater Research Institute - The University of Queensland, Faculty of Medicine and Biomedical Sciences, Translational Research Institute, 37 Kent Street, Woolloongabba, 4102, Australia. Electronic address: allison.pettit@mater.uq.edu.au.
authors: Allison Robyn
authors: AR
authors: Pettit
mesh_terms: D000818:Animals; D001853:Bone Marrow / Q000473:pathology*; D001842:Bone and Bones / Q000473:pathology*; D006706:Homeostasis; D006801:Humans; D008264:Macrophages / Q000473:pathology*; D055153:Stem Cell Niche; D014945:Wound Healing
keywords: Bone and bone marrow; Haematopoiesis; Macrophages; Stem cell niches