title: 5-(2-Aminopropyl)benzofuran and phenazepam demonstrate the possibility of dependence by increasing dopamine levels in the brain.
abstract: Although 5-(2-aminopropyl)benzofuran (5-APB) and 7-bromo-5-(2-chlorophenyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-one (phenazepam) are being used as recreational drugs, research on their dependence liability or mechanisms of action is lacking. The present study aimed to evaluate the behavioral effects and dependence liability of these drugs using conditioned place preference and self-administration paradigms in rodents. Additionally, biochemical techniques were used to assess the substance-induced alterations in synaptosome-released dopamine. While both of the tested substances elicited increases in conditioned place preference and dopamine, neither of them facilitated self-administration, suggesting that 5-APB and phenazepam have rewarding effects, rather than reinforcing effects.
authors: Pharmacological Research Division, Toxicological Evaluation and Research Department, National Institute of Food and Drug Safety Evaluation, Ministry of Food and Drug Safety, 187 Osong Saengmyeong 2-ro, Heungdeok-gu, Chungju-shi 28159, Republic of Korea. Electronic address: chahj1@korea.kr.
authors: Hye Jin
authors: HJ
authors: Cha
authors: Pharmacological Research Division, Toxicological Evaluation and Research Department, National Institute of Food and Drug Safety Evaluation, Ministry of Food and Drug Safety, 187 Osong Saengmyeong 2-ro, Heungdeok-gu, Chungju-shi 28159, Republic of Korea.
authors: Kwang-Wook
authors: KW
authors: Lee
authors: Pharmacological Research Division, Toxicological Evaluation and Research Department, National Institute of Food and Drug Safety Evaluation, Ministry of Food and Drug Safety, 187 Osong Saengmyeong 2-ro, Heungdeok-gu, Chungju-shi 28159, Republic of Korea.
authors: Jang-Hyeon
authors: JH
authors: Eom
authors: Pharmacological Research Division, Toxicological Evaluation and Research Department, National Institute of Food and Drug Safety Evaluation, Ministry of Food and Drug Safety, 187 Osong Saengmyeong 2-ro, Heungdeok-gu, Chungju-shi 28159, Republic of Korea.
authors: Young-Hoon
authors: YH
authors: Kim
authors: Pharmacological Research Division, Toxicological Evaluation and Research Department, National Institute of Food and Drug Safety Evaluation, Ministry of Food and Drug Safety, 187 Osong Saengmyeong 2-ro, Heungdeok-gu, Chungju-shi 28159, Republic of Korea.
authors: Jisoon
authors: J
authors: Shin
authors: Pharmacological Research Division, Toxicological Evaluation and Research Department, National Institute of Food and Drug Safety Evaluation, Ministry of Food and Drug Safety, 187 Osong Saengmyeong 2-ro, Heungdeok-gu, Chungju-shi 28159, Republic of Korea.
authors: Jaesuk
authors: J
authors: Yun
authors: Pharmacological Research Division, Toxicological Evaluation and Research Department, National Institute of Food and Drug Safety Evaluation, Ministry of Food and Drug Safety, 187 Osong Saengmyeong 2-ro, Heungdeok-gu, Chungju-shi 28159, Republic of Korea.
authors: Kyoungmoon
authors: K
authors: Han
authors: Pharmacological Research Division, Toxicological Evaluation and Research Department, National Institute of Food and Drug Safety Evaluation, Ministry of Food and Drug Safety, 187 Osong Saengmyeong 2-ro, Heungdeok-gu, Chungju-shi 28159, Republic of Korea.
authors: Hyung Soo
authors: HS
authors: Kim
mesh_terms: D000818:Animals; D001569:Benzodiazepines / Q000008:administration & dosage*; D001572:Benzofurans / Q000008:administration & dosage*; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D015198:Designer Drugs / Q000008:administration & dosage*; D004298:Dopamine / Q000096:biosynthesis*; D004305:Dose-Response Relationship, Drug; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D011437:Propylamines / Q000008:administration & dosage*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012646:Self Administration; D019966:Substance-Related Disorders / Q000378:metabolism*
chemical_list: D001572:Benzofurans; D015198:Designer Drugs; D011437:Propylamines; D001569:Benzodiazepines; C000608250:5-(2-aminopropyl)benzofuran; C017928:phenazepam; D004298:Dopamine
keywords: 5-APB; Dependence; Dopamine; Phenazepam; Synaptosome