title: Cutaneous beta human papillomaviruses and the development of male external genital lesions: A case-control study nested within the HIM Study.
abstract: Cutaneous human papillomaviruses (HPVs) increase the risk of non-melanoma skin cancer in sun-exposed skin. We examined the role of beta-HPV in the development of male external genital lesions (EGLs), a sun-unexposed site.
  
  
  
  In this nested case-control study (67 men with pathologically-confirmed EGLs and 134 controls), exfoliated cells collected from the surface of lesions and normal genital skin 0, 6, and 12 months preceding EGL development were tested for beta-HPV DNA using a type-specific multiplex genotyping assay. Beta-HPV prevalence was estimated and conditional logistic regression was used to evaluate the association with condyloma, the most common EGL.
  
  
  
  While beta-HPV prevalence among controls remained stable, the prevalence among cases was lowest on the surface of lesion. Detecting beta-HPV on the normal genital skin was not associated with the presence or development of condyloma.
  
  
  
  Cutaneous beta-HPV does not appear to be contributing to pathogenesis in male genital skin.
authors: Center for Infection Research in Cancer, Moffitt Cancer Center and Research Institute, Tampa, FL, USA; Department of Cancer Epidemiology, Moffitt Cancer Center and Research Institute, Tampa, FL, USA.
authors: Christine M
authors: CM
authors: Pierce Campbell
authors: Infections and Cancer Biology Group, International Agency for Research on Cancer, Lyon, France.
authors: Tarik
authors: T
authors: Gheit
authors: Infections and Cancer Biology Group, International Agency for Research on Cancer, Lyon, France.
authors: Massimo
authors: M
authors: Tommasino
authors: Biostatistics Program, School of Public Health, Louisiana State University Health Sciences Center, New Orleans, LA, USA.
authors: Hui-Yi
authors: HY
authors: Lin
authors: Department of Cancer Epidemiology, Moffitt Cancer Center and Research Institute, Tampa, FL, USA.
authors: B Nelson
authors: BN
authors: Torres
authors: Departments of Anatomic Pathology and Cutaneous Oncology, Moffitt Cancer Center and Research Institute, Tampa, FL, USA; Departments of Oncologic Sciences, Pathology, and Cell Biology and Dermatology, University of South Florida Morsani College of Medicine, Tampa, FL, USA.
authors: Jane L
authors: JL
authors: Messina
authors: Department of Pathology, University of Virginia Health System, Charlottesville, VA, USA.
authors: Mark H
authors: MH
authors: Stoler
authors: Center for Infection Research in Cancer, Moffitt Cancer Center and Research Institute, Tampa, FL, USA; Department of Cancer Epidemiology, Moffitt Cancer Center and Research Institute, Tampa, FL, USA.
authors: Dana E
authors: DE
authors: Rollison
authors: Center for Infection Research in Cancer, Moffitt Cancer Center and Research Institute, Tampa, FL, USA; Department of Cancer Epidemiology, Moffitt Cancer Center and Research Institute, Tampa, FL, USA.
authors: Bradley A
authors: BA
authors: Sirak
authors: Center for Infection Research in Cancer, Moffitt Cancer Center and Research Institute, Tampa, FL, USA; Department of Cancer Epidemiology, Moffitt Cancer Center and Research Institute, Tampa, FL, USA.
authors: Martha
authors: M
authors: Abrahamsen
authors: Center for Reference and Training in STD/AIDS, São Paulo, Brazil.
authors: Roberto J
authors: RJ
authors: Carvalho da Silva
authors: Center for Translational Research in Oncology, Instituto do Câncer do Estado de São Paulo (ICESP), São Paulo, Brazil.
authors: Laura
authors: L
authors: Sichero
authors: Center for Translational Research in Oncology, Instituto do Câncer do Estado de São Paulo (ICESP), São Paulo, Brazil; Department of Radiology and Oncology, School of Medicine, Universidade de São Paulo, São Paulo, Brazil.
authors: Luisa L
authors: LL
authors: Villa
authors: Center for Population Health Research, Instituto Nacional de Salud Pública (INSP), Cuernavaca, México.
authors: Eduardo
authors: E
authors: Lazcano-Ponce
authors: Center for Infection Research in Cancer, Moffitt Cancer Center and Research Institute, Tampa, FL, USA; Department of Cancer Epidemiology, Moffitt Cancer Center and Research Institute, Tampa, FL, USA. Electronic address: Anna.Giuliano@moffitt.org.
authors: Anna R
authors: AR
authors: Giuliano
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D052686:Betapapillomavirus / Q000145:classification / Q000502:physiology*; D016022:Case-Control Studies; D004279:DNA, Viral; D005832:Genital Diseases, Male / Q000453:epidemiology / Q000821:virology*; D005837:Genitalia, Male / Q000473:pathology / Q000821:virology; D006801:Humans; D008297:Male; D008875:Middle Aged; D058889:Molecular Typing; D016017:Odds Ratio; D030361:Papillomavirus Infections / Q000453:epidemiology / Q000821:virology*; D015995:Prevalence; D012307:Risk Factors; D012725:Sexual Behavior; D055815:Young Adult
chemical_list: D004279:DNA, Viral
keywords: Beta-HPV; Condyloma; Cutaneous HPV; Genital lesions; HIM Study