title: Pediatric malignant salivary gland tumors: 60 year follow up.
abstract: OBJECTIVE
  To evaluate the presentation, treatments and outcomes in pediatric patients with salivary gland malignancies.
  
  
  METHODS
  Retrospective chart review (1950-2012), Prospective phone interview.
  
  
  METHODS
  Patients ≤18 years old with a salivary gland malignancy treated at our institution were identified. Patients were also contacted by phone for a follow up survey.
  
  
  RESULTS
  Fifty-six patients were identified. Tumor origin was 88% parotid (n = 49), 5% (n = 3) submandibular and 7% (n = 4) minor salivary glands. Time from onset of symptoms to diagnosis was over one year (mean = 14.4 years). Fifteen out of 52 patients with major gland malignancy had a locoregional recurrence and local recurrences were almost all after initial enucleation. Two of these patients died of disease (overall disease specific survival = 96%). Three out of 4 patients with minor gland malignancy had a local recurrence and two patients with high grade pathology developed metastases and died of their disease (overall survival = 50%). On long term follow up survey in 13 patients (25%), 100% reported normal facial movement and 54% described symptoms of Frey's syndrome, which is higher than other reported series in children. Recurrence was noted up to 45 years after initial treatment.
  
  
  CONCLUSIONS
  The majority of malignant pediatric salivary gland tumors are low grade and have excellent survival, especially if found at an early stage. Minor salivary gland malignancies, particularly high grade, have a worse prognosis. Long term mild Frey's syndrome can be expected in approximately half of patients. We advocate a need for long term follow up and increased awareness among providers to diagnose these patients earlier.
authors: Mayo Clinic Department of Otorhinolaryngology, Head and Neck Surgery, 200 First St SW, Rochester, MN, 55905, USA. Electronic address: Cockerill.Cara@mayo.edu.
authors: Cara C
authors: CC
authors: Cockerill
authors: Mayo Clinic Department of Otorhinolaryngology, Head and Neck Surgery, 200 First St SW, Rochester, MN, 55905, USA. Electronic address: Briangross81@gmail.com.
authors: Brian C
authors: BC
authors: Gross
authors: Mayo Clinic Department of Otorhinolaryngology, Head and Neck Surgery, 200 First St SW, Rochester, MN, 55905, USA. Electronic address: Wise.Stephanie@mayo.edu.
authors: Stephanie
authors: S
authors: Contag
authors: Mayo Clinic Department of Otorhinolaryngology, Head and Neck Surgery, 200 First St SW, Rochester, MN, 55905, USA. Electronic address: reinx046@umn.edu.
authors: Sarah
authors: S
authors: Rein
authors: Mayo Clinic Department of Otorhinolaryngology, Head and Neck Surgery, 200 First St SW, Rochester, MN, 55905, USA. Electronic address: Moore.Eric@mayo.edu.
authors: Eric J
authors: EJ
authors: Moore
authors: Mayo Clinic Department of Otorhinolaryngology, Head and Neck Surgery, 200 First St SW, Rochester, MN, 55905, USA. Electronic address: Olsen.Kerry@mayo.edu.
authors: Kerry D
authors: KD
authors: Olsen
authors: Mayo Clinic Department of Otorhinolaryngology, Head and Neck Surgery, 200 First St SW, Rochester, MN, 55905, USA. Electronic address: Orvidas.Laura@mayo.edu.
authors: Laura J
authors: LJ
authors: Orvidas
mesh_terms: D000293:Adolescent; D002277:Carcinoma / Q000453:epidemiology / Q000473:pathology / Q000601:surgery; D002648:Child; D002675:Child, Preschool; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008223:Lymphoma / Q000453:epidemiology / Q000473:pathology / Q000601:surgery; D008297:Male; D008910:Minnesota / Q000453:epidemiology; D009364:Neoplasm Recurrence, Local / Q000453:epidemiology; D012189:Retrospective Studies; D012468:Salivary Gland Neoplasms / Q000453:epidemiology / Q000473:pathology / Q000601:surgery*; D012509:Sarcoma / Q000453:epidemiology / Q000473:pathology / Q000601:surgery; D013547:Sweating, Gustatory / Q000453:epidemiology; D013997:Time Factors
keywords: Cancer; Outcome; Pediatric; Salivary gland; Tumor