title: Antigenic characterization of classical swine fever virus YC11WB isolates from wild boar.
abstract: Classical swine fever (CSF), a highly contagious disease that affects domestic pigs and wild boar, has serious economic implications. The present study examined the virulence and transmission of CSF virus strain YC11WB (isolated from a wild boar in 2011) in breeding wild boar. Virulence of strain YC11WB in domestic pigs was also examined. Based on the severe clinical signs and high mortality observed among breeding wild boar, the pathogenicity of strain YC11WB resembled that of typical acute CSF. Surprisingly, in contrast to strain SW03 (isolated from breeding pigs in 2003), strain YC11WB showed both acute and strong virulence in breeding pigs. None of three specific monoclonal antibodies (7F2, 7F83, and 6F65) raised against the B/C domain of the SW03 E2 protein bound to the B/C domain of strain YC11WB due to amino acid mutations (720K→R and723N→S) in the YC11WB E2 protein. Although strains YC11WB and SW03 belong to subgroup 2.1b, they had different mortality rates in breeding pigs. Thus, if breeding pigs have not developed protective immunity against CSF virus, they may be susceptible to strain YC11WB transmitted by wild boar, resulting in severe economic losses for the pig industry.
authors: Animal and Plant Quarantine Agency, Gimcheon 39660, Korea.
authors: Seong-In
authors: SI
authors: Lim
authors: Animal and Plant Quarantine Agency, Gimcheon 39660, Korea.
authors: Yong Kwan
authors: YK
authors: Kim
authors: Animal and Plant Quarantine Agency, Gimcheon 39660, Korea.
authors: Ji-Ae
authors: JA
authors: Lim
authors: Animal and Plant Quarantine Agency, Gimcheon 39660, Korea.
authors: Song-Hee
authors: SH
authors: Han
authors: Animal and Plant Quarantine Agency, Gimcheon 39660, Korea.
authors: Hee-Suk
authors: HS
authors: Hyun
authors: Animal and Plant Quarantine Agency, Gimcheon 39660, Korea.
authors: Ki-Sun
authors: KS
authors: Kim
authors: Animal and Plant Quarantine Agency, Gimcheon 39660, Korea.
authors: Bang-Hun
authors: BH
authors: Hyun
authors: Animal and Plant Quarantine Agency, Gimcheon 39660, Korea.
authors: Jae-Jo
authors: JJ
authors: Kim
authors: Animal and Plant Quarantine Agency, Gimcheon 39660, Korea.
authors: In-Soo
authors: IS
authors: Cho
authors: Animal and Plant Quarantine Agency, Gimcheon 39660, Korea.
authors: Jae-Young
authors: JY
authors: Song
authors: Korea Pork Producers Association, Seoul 06643, Korea.
authors: Sung-Hyun
authors: SH
authors: Choi
authors: Korea Pork Producers Association, Seoul 06643, Korea.
authors: Seung-Hoe
authors: SH
authors: Kim
authors: Animal and Plant Quarantine Agency, Gimcheon 39660, Korea.
authors: Dong-Jun
authors: DJ
authors: An
mesh_terms: D000818:Animals; D000835:Animals, Wild / Q000276:immunology / Q000821:virology; D000911:Antibodies, Monoclonal / Q000276:immunology; D000956:Antigens, Viral / Q000276:immunology*; D006691:Classical Swine Fever / Q000276:immunology* / Q000635:transmission / Q000821:virology; D006692:Classical Swine Fever Virus / Q000276:immunology* / Q000302:isolation & purification / Q000472:pathogenicity; D003001:Cloning, Molecular; D060888:Real-Time Polymerase Chain Reaction / Q000662:veterinary; D034421:Sus scrofa / Q000821:virology*; D013552:Swine
chemical_list: D000911:Antibodies, Monoclonal; D000956:Antigens, Viral
keywords: B/C domain; Classical swine fever virus; Sus scrofa; virulence