title: Mobile genetic elements related to carbapenem resistance in Acinetobacter baumannii.
abstract: Acinetobacter baumannii is widely recognized as an important pathogen associated with nosocomial infections. The treatment of these infections is often difficult due to the acquisition of resistance genes. A. baumannii presents a high genetic plasticity which allows the accumulation of these resistance determinants leading to multidrug resistance. It is highlighted the importance of the horizontal transfer of resistance genes, through mobile genetic elements and its relationship with increased incidence of multidrug resistant A. baumannii in hospitals. Considering that resistance to carbapenems is very important from the clinical and epidemiological point of view, the aim of this article is to present an overview of the current knowledge about genetic elements related to carbapenem resistance in A. baumannii such as integrons, transposons, resistance islands and insertion sequences.
authors: Universidade Federal do Rio Grande do Sul (UFRGS), Faculdade de Farmácia, Programa de Pós-Gradução em Ciências Farmacêuticas, Porto Alegre, Brazil; Hospital de Clínicas de Porto Alegre(HCPA), Porto Alegre, Brazil.
authors: Mariana
authors: M
authors: Pagano
authors: Universidade Federal do Rio Grande do Sul (UFRGS), Instituto de Ciências Básicas da Saúde, Porto Alegre, Brazil; Hospital de Clínicas de Porto Alegre(HCPA), Porto Alegre, Brazil. Electronic address: andrezafm20@gmail.com.
authors: Andreza Francisco
authors: AF
authors: Martins
authors: Universidade Federal do Rio Grande do Sul (UFRGS), Faculdade de Farmácia, Programa de Pós-Gradução em Ciências Farmacêuticas, Porto Alegre, Brazil; Hospital de Clínicas de Porto Alegre(HCPA), Porto Alegre, Brazil.
authors: Afonso Luis
authors: AL
authors: Barth
mesh_terms: D040981:Acinetobacter baumannii / Q000187:drug effects* / Q000235:genetics*; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D015780:Carbapenems / Q000494:pharmacology*; D004251:DNA Transposable Elements; D004269:DNA, Bacterial; D044404:Genomic Islands; D032023:Integrons; D016254:Mutagenesis, Insertional; D018440:beta-Lactam Resistance
chemical_list: D000900:Anti-Bacterial Agents; D015780:Carbapenems; D004251:DNA Transposable Elements; D004269:DNA, Bacterial
keywords: Acinetobacter baumannii; Antimicrobial resistance; Carbapenem resistance; Mobile genetic elements