title: Correlation of cardiac troponin I levels with infective endocarditis & its adverse clinical outcomes.
abstract: BACKGROUND
  To study the association of increased cardiac troponin I levels in infective endocarditis (IE) with its adverse clinical outcomes including in-hospital mortality, perivalvular invasive infection and central nervous system events.
  
  
  METHODS
  A prospective cohort study of 26 patients comprising of 19 males and 7 females with an average age of 28years diagnosed with IE using Modified Duke Criteria were taken. A blood sample was drawn from each patient and all samples were analyzed for quantitative estimation of troponin I using ELISA technique. A cardiac troponin I level >1.0ng/ml was considered increased. All data was analyzed by independent- samples t test using SPSS Version 16.0.
  
  
  RESULTS
  All 26 patients had vegetations diagnosed on echocardiography. Of the 26 patients, 9 (35%) had elevated cardiac troponin I levels and 17 patients (65%) had normal cardiac troponin I levels. Of the 9 patients who had elevated cardiac troponin I levels, 7 (77.78%) had adverse clinical outcomes, the level of statistical significance being p value<0.0002. Of the 17 patients with normal cardiac troponin I levels, only 1 (5.88%) had adverse clinical outcome, the level of statistical significance being p value<0.0001.
  
  
  CONCLUSIONS
  Patients with IE and increased cardiac troponin I levels have worse prognosis with increased incidence of adverse clinical outcomes than those with IE and normal cardiac troponin I levels reflecting potential of cardiac troponin I as a prognostic marker in IE.
authors: SKIMS Srinagar, Senior Resident HIMSR New Delhi, India. Electronic address: s.ahmad502900@gmail.com.
authors: Zubair Ahmed
authors: ZA
authors: Thoker
authors: Department of Cardiology, SKIMS Srinagar, India.
authors: Khursheed Aslam
authors: KA
authors: Khan
authors: Department of Immunology, SKIMS Srinagar, India.
authors: Imtiyaz
authors: I
authors: Rashid
authors: Department of Immunology, SKIMS Srinagar, India.
authors: Zafar
mesh_terms: D000293:Adolescent; D000328:Adult; D015415:Biomarkers / Q000097:blood; D002648:Child; D004452:Echocardiography; D004696:Endocarditis / Q000097:blood* / Q000175:diagnosis / Q000401:mortality; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005500:Follow-Up Studies; D017052:Hospital Mortality / Q000639:trends; D006801:Humans; D007194:India / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D015996:Survival Rate / Q000639:trends; D019210:Troponin I / Q000097:blood*; D055815:Young Adult
chemical_list: D015415:Biomarkers; D019210:Troponin I
keywords: Blood cultures; Echocardiography; Infective endocarditis; Troponin I; Valvular vegetations