title: Total Synthesis of Anticancer Agent EBC-23.
abstract: Total synthesis of spiroketal EBC-23 has been described by two divergent approaches from three simple building blocks. Gold-catalyzed cycloisomerization of alkynol and acid-mediated spirocyclization of diketalketone were successfully utilized to effect spiroketal formation. A Cu(I)-P(Cy)3-catalyzed protocol for the highly regio- and stereocontrolled hydroboration of internal propargylic alcohol was effectively applied toward the β-hydroxy ketone via vinylboronates.
authors: Academy of Scientific and Innovative Research (AcSIR) , New Delhi 110020, India.
authors: Dodda Vasudeva
authors: DV
authors: Reddy
authors: Gowravaram
authors: G
authors: Sabitha
authors: Tadikamalla Prabhakar
authors: TP
authors: Rao
authors: Academy of Scientific and Innovative Research (AcSIR) , New Delhi 110020, India.
authors: Jhillu Singh
authors: JS
authors: Yadav