title: Cycloxaprid: A novel cis-nitromethylene neonicotinoid insecticide to control imidacloprid-resistant cotton aphid (Aphis gossypii).
abstract: Imidacloprid is a nicotinic acetylcholine receptor (nAChR) agonist with potent insecticidal activity. However, resistance to imidacloprid is a significant threat and has been identified in several pest species. Cycloxaprid with cis-configuration is a novel neonicotinoid insecticide, which shows high activity against imidacloprid-resistant pests. The LC50 of imidacloprid against the resistant Aphis gossypii was 14.33mgL(-1) while it was only 0.70mgL(-1) for the susceptible population, giving a resistance ratio of 20.47. In this imidacloprid-resistant population, a point mutation (R81T) located in the loop D region of the nAChR β1 subunit was found out. But this point mutation did not decrease the activity of cycloxaprid against A. gossypii. The LC50 of cycloxaprid was 1.05 and 1.36mgL(-1) for the imidacloprid-susceptible and imidacloprid-resistant populations, respectively. In addition, cycloxaprid provided better efficacies against resistant A. gossypii than imidacloprid in the fields. Although cycloxaprid was highly toxic to A. gossypii, it showed high selective activity between A. gossypii and its predominant natural enemies, Harmonia axyridis and Chrysoperla sinica. These results demonstrate that cycloxaprid is a promising insecticide against imidacloprid-resistant A. gossypii and suitable for the integrated pest management.
authors: Key Laboratory of Integrated Pest Management in Crops, Ministry of Agriculture, Institute of Plant Protection, Chinese Academy of Agricultural Sciences, Beijing 100193, China.
authors: Li
authors: L
authors: Cui
authors: Key Laboratory of Integrated Pest Management in Crops, Ministry of Agriculture, Institute of Plant Protection, Chinese Academy of Agricultural Sciences, Beijing 100193, China; College of Plant Protection, Key Laboratory of Pesticide Toxicology & Application Technique, Shandong Agricultural University, Tai'an, Shandong 271018, China.
authors: Haoliang
authors: H
authors: Qi
authors: Key Laboratory of Integrated Pest Management in Crops, Ministry of Agriculture, Institute of Plant Protection, Chinese Academy of Agricultural Sciences, Beijing 100193, China.
authors: Daibin
authors: D
authors: Yang
authors: Key Laboratory of Integrated Pest Management in Crops, Ministry of Agriculture, Institute of Plant Protection, Chinese Academy of Agricultural Sciences, Beijing 100193, China. Electronic address: hzhyuan@ippcaas.cn.
authors: Huizhu
authors: H
authors: Yuan
authors: Key Laboratory of Integrated Pest Management in Crops, Ministry of Agriculture, Institute of Plant Protection, Chinese Academy of Agricultural Sciences, Beijing 100193, China. Electronic address: chrui@ippcaas.cn.
authors: Changhui
authors: C
authors: Rui
mesh_terms: D000818:Animals; D001042:Aphids; D003368:Gossypium / Q000469:parasitology; D006575:Heterocyclic Compounds, 3-Ring; D007093:Imidazoles; D007300:Insect Control / Q000379:methods; D007305:Insecticide Resistance; D007306:Insecticides; D000073943:Neonicotinoids; D009574:Nitro Compounds; D011725:Pyridines
chemical_list: D006575:Heterocyclic Compounds, 3-Ring; D007093:Imidazoles; D007306:Insecticides; D000073943:Neonicotinoids; D009574:Nitro Compounds; D011725:Pyridines; C583366:cycloxaprid; C082359:imidacloprid
keywords: Aphis gossypii; Cycloxaprid; Imidacloprid; Natural enemy; Resistance