title: Who Is in the Driver's Seat: Tracing Cancer Genes Using CRISPR-Barcoding.
abstract: Intratumor heterogeneity is thought to be the driving force of tumor evolution and therapy resistance. Yet tools to study these processes are limited. In this issue, Guernet et al. (2016) devised clustered regularly interspaced short palindromic repeats (CRISPR)-barcoding to functionally annotate specific mutations and study clonal evolution in heterogeneous cell populations.
authors: Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences (KNAW) and UMC Utrecht, 3584CT Utrecht, the Netherlands; Cancer Genomics Netherlands, UMC Utrecht, 3584CG Utrecht, the Netherlands.
authors: Jarno
authors: J
authors: Drost
authors: Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences (KNAW) and UMC Utrecht, 3584CT Utrecht, the Netherlands; Cancer Genomics Netherlands, UMC Utrecht, 3584CG Utrecht, the Netherlands. Electronic address: h.clevers@hubrecht.eu.
authors: Hans
authors: H
authors: Clevers
mesh_terms: D064112:Clustered Regularly Interspaced Short Palindromic Repeats; D006801:Humans; D009154:Mutation; D009857:Oncogenes