title: Effect of Circulation Parameters on Functional Status of HepaRG Spheroids Cultured in Microbioreactor.
abstract: We studied the relationship between microcirculation parameters and functional status of HepaRG cells in spheroids and chose an optimal regimen within the physiologically permissible limits of mechanical impact for the cells that maintains the expression of functional genes of the liver.
authors: Moscow Aircraft Construction Institute (National Research University), Moscow, Russia.
authors: O V
authors: OV
authors: Semenova
authors: Moscow Aircraft Construction Institute (National Research University), Moscow, Russia.
authors: V A
authors: VA
authors: Petrov
authors: Moscow Aircraft Construction Institute (National Research University), Moscow, Russia.
authors: T N
authors: TN
authors: Gerasimenko
authors: Moscow Aircraft Construction Institute (National Research University), Moscow, Russia.
authors: A V
authors: AV
authors: Aleksandrova
authors: Moscow Aircraft Construction Institute (National Research University), Moscow, Russia.
authors: O A
authors: OA
authors: Burmistrova
authors: Moscow Aircraft Construction Institute (National Research University), Moscow, Russia. n.khutornenko@bioclinicum.com.
authors: A A
authors: AA
authors: Khutornenko
authors: Moscow Aircraft Construction Institute (National Research University), Moscow, Russia.
authors: A I
authors: AI
authors: Osipyants
authors: Moscow Aircraft Construction Institute (National Research University), Moscow, Russia.
authors: A A
authors: AA
authors: Poloznikov
authors: Moscow Aircraft Construction Institute (National Research University), Moscow, Russia.
authors: D A
authors: DA
authors: Sakharov
mesh_terms: D019149:Bioreactors; D002470:Cell Survival / Q000502:physiology; D022781:Hepatocytes / Q000166:cytology; D006801:Humans; D008099:Liver / Q000166:cytology*; D008833:Microcirculation / Q000502:physiology
keywords: HepaRG spheroids; liver-on-a-chip; microcirculation