title: Evaluation of neutrophil-lymphocyte ratio in patients with early-stage mycosis fungoides.
abstract: Neutrophil-lymphocyte ratio (NLR), an indicator of inflammation, has been lately demonstrated as a prognostic factor and an indicator of disease activity in various diseases. However, the effects of NLR have not been investigated in mycosis fungoides (MF) patients yet. The aim of this study is to investigate the relationship between the NLR and treatment demand (systemic PUVA and/or chemotherapy), time to treatment, progression in stage, and time to progression in stage in MF patients. The data of 117 patients, who were followed with the diagnosis of MF at the Department of Dermatology in Istanbul Training and Research Hospital between April 2006 and January 2016, were analyzed retrospectively. The cutoff score for NLR was determined as 2 according to the median NLR level which was 1.96. At the time of diagnosis, the median age of patients was 54 years (range, 21-90) with 62 (53 %) female and 55 (47 %) male. Seventy-seven (65.8 %) patients required treatment during follow-up. Sixty-three (53.8 %) patients showed progression in disease stage. There was no significant difference in treatment demand, time to treatment, progression in stage, and time to progression in stage in patients with a NLR ≥ 2 and NLR < 2 (p = 0.331, 0.987, 0.065, and 0.119, respectively). It seems that there is no association between the NLR and treatment demand, time to treatment, progression in stage, and time to progression in stage in MF patients.
authors: Department of Hematology, Istanbul Training and Research Hospital, Fatih, Istanbul, Turkey.
authors: Rafet
authors: R
authors: Eren
authors: Department of Internal Medicine, Istanbul Training and Research Hospital, Istanbul, Turkey.
authors: Nihan
authors: N
authors: Nizam
authors: Department of Hematology, Istanbul Training and Research Hospital, Fatih, Istanbul, Turkey.
authors: Mehmet Hilmi
authors: MH
authors: Doğu
authors: Department of Dermatology, Istanbul Training and Research Hospital, Istanbul, Turkey.
authors: Sevgi
authors: S
authors: Mercan
authors: Department of Dermatology, Istanbul Training and Research Hospital, Istanbul, Turkey.
authors: Aslı Vefa Turgut
authors: AV
authors: Erdemir
authors: Department of Hematology, Istanbul Training and Research Hospital, Fatih, Istanbul, Turkey. elifsuyani@hotmail.com.
authors: Elif
authors: E
authors: Suyanı
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000627:therapeutic use; D003520:Cyclophosphamide / Q000008:administration & dosage; D018450:Disease Progression; D018572:Disease-Free Survival; D004317:Doxorubicin / Q000008:administration & dosage; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D007958:Leukocyte Count; D008214:Lymphocytes; D008297:Male; D008875:Middle Aged; D009182:Mycosis Fungoides / Q000097:blood* / Q000188:drug therapy / Q000473:pathology; D009367:Neoplasm Staging; D009504:Neutrophils; D011701:PUVA Therapy; D011241:Prednisone / Q000008:administration & dosage; D012189:Retrospective Studies; D014750:Vincristine / Q000008:administration & dosage; D055815:Young Adult
chemical_list: D014750:Vincristine; D004317:Doxorubicin; D003520:Cyclophosphamide; D011241:Prednisone
keywords: Lymphocyte; Lymphoma; Mycosis fungoides; Neutrophil; Neutrophil–lymphocyte ratio