title: Amplitude of Glottal Mucosal Wave After Vocal Fold Microflap With or Without Fibrin Glue.
abstract: BACKGROUND
  The vocal fold microflap technique is the ideal to remove benign vocal fold pathology. Our objective is to compare the amplitudes of the mucosal wave before and after the closure of microflap defect with fibrin glue, and when microflap is left to heal by secondary intention.
  
  
  METHODS
  The present study is a retrospective series, including 32 patients treated by intracordal phonosurgery, with closure of the microflap either with fibrin glue or by healing by secondary intention. They all had both preoperative and 6-month postoperative track records to allow voice analysis, a subjective Voice Handicap Index 10 (VHI-10), and a good image quality strobe.
  
  
  RESULTS
  After selecting the patients was found that the mean overall preoperative VHI-10 was 26.6, and improved up to 10.5 after surgery, a statistical differences (P = 0.03). When comparing both groups, with or without fibrin glue, fibrin glue did not improved results in VHI-10. On the contrary, there was a significant difference in the improvement of the open glottal phase after surgery (P = 0.03), showing a much higher improvement when fibrin glue was used.
  
  
  CONCLUSIONS
  The use of fibrin glue after a vocal fold microflap for advanced pathology, such as sulcus vocalis in pocket, vergeture, or vocal fold scar, increases the amplitude of the mucosal wave of the vocal folds, but does not improve the VHI-10 results in our cohort of female patients. So far, patient-reported outcome shows that healing by secondary intention continues to provide excellent voice results.
authors: Department of Otolaryngology, Hospital Universitario de Fuenlabrada, Fuenlabrada, Madrid, Spain. Electronic address: rgonzalez.hflr@salud.madrid.org.
authors: Ramón
authors: R
authors: González-Herranz
authors: Department of Otolaryngology, Hospital Universitario de Fuenlabrada, Fuenlabrada, Madrid, Spain.
authors: Elizabeth
authors: E
authors: Amarillo
authors: Department of Otolaryngology, Hospital Universitario de Fuenlabrada, Fuenlabrada, Madrid, Spain.
authors: Estefanía
authors: E
authors: Hernández-García
authors: Department of Otolaryngology, Hospital Universitario de Fuenlabrada, Fuenlabrada, Madrid, Spain.
authors: José
authors: J
authors: Montojo Woodeson
authors: Department of Otolaryngology, Hospital Universitario de Fuenlabrada, Fuenlabrada, Madrid, Spain.
authors: Guillermo
authors: G
authors: Plaza-Mayor
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D004185:Disability Evaluation; D005260:Female; D015718:Fibrin Tissue Adhesive / Q000008:administration & dosage* / Q000009:adverse effects; D005931:Glottis / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000601:surgery*; D006801:Humans; D007818:Laryngeal Diseases / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000601:surgery*; D008866:Microsurgery / Q000009:adverse effects / Q000379:methods*; D008875:Middle Aged; D010699:Phonation; D020127:Recovery of Function; D020545:Respiratory Mucosa / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000601:surgery*; D012189:Retrospective Studies; D049489:Stroboscopy; D013524:Surgical Flaps; D013997:Time Factors; D014014:Tissue Adhesives / Q000008:administration & dosage* / Q000009:adverse effects; D016896:Treatment Outcome; D014732:Vibration; D014827:Vocal Cords / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000601:surgery*; D014833:Voice Quality; D014945:Wound Healing; D055815:Young Adult
chemical_list: D015718:Fibrin Tissue Adhesive; D014014:Tissue Adhesives
keywords: Fibrin glue; Glottal mucosal wave; Sulcus vocalis; Vergeture; Vocal fold microflap