title: The Cytokine CXCL12 Promotes Basket Interneuron Inhibitory Synapses in the Medial Prefrontal Cortex.
abstract: Prenatally, the cytokine CXCL12 regulates cortical interneuron migration, whereas its postnatal functions are poorly understood. Here, we report that CXCL12 is expressed postnatally in layer V pyramidal neurons and localizes on their cell bodies in the medial prefrontal cortex (mPFC), while its receptors CXCR4/CXCR7 localize to the axon terminals of parvalbumin (PV) interneurons. Conditionally eliminating CXCL12 in neonatal layer V pyramidal neurons led to decreased axon targeting and reduced inhibitory perisomatic synapses from PV+ basket interneurons onto layer V pyramidal neurons. Consequently, the mPFC of Cxcl12 conditional mutants displayed attenuated inhibitory postsynaptic currents onto layer V pyramidal neurons. Thus, postnatal CXCL12 signaling promotes a specific interneuron circuit that inhibits mPFC activity.
authors: Department of Psychiatry, University of California, San Francisco, San Francisco, CA 94143, USA.
authors: Pei-Rung
authors: PR
authors: Wu
authors: Department of Psychiatry, University of California, San Francisco, San Francisco, CA 94143, USA.|Center for Integrative Neuroscience, University of California, San Francisco, San Francisco, CA 94143, USA.|Sloan-Swartz Center for Theoretical Neurobiology, University of California, San Francisco, San Francisco, CA 94143, USA.
authors: Kathleen K A
authors: KKA
authors: Cho
authors: Department of Psychiatry, University of California, San Francisco, San Francisco, CA 94143, USA.
authors: Daniel
authors: D
authors: Vogt
authors: Department of Psychiatry, University of California, San Francisco, San Francisco, CA 94143, USA.|Center for Integrative Neuroscience, University of California, San Francisco, San Francisco, CA 94143, USA.|Sloan-Swartz Center for Theoretical Neurobiology, University of California, San Francisco, San Francisco, CA 94143, USA.
authors: Vikaas S
authors: VS
authors: Sohal
authors: Department of Psychiatry, University of California, San Francisco, San Francisco, CA 94143, USA.
authors: John L R
authors: JLR
authors: Rubenstein
mesh_terms: D000818:Animals; D001369:Axons / Q000378:metabolism; D054377:Chemokine CXCL12 / Q000235:genetics / Q000378:metabolism*; D053444:Inhibitory Postsynaptic Potentials / Q000502:physiology; D007395:Interneurons / Q000378:metabolism*; D008822:Mice, Transgenic; D010320:Parvalbumins / Q000378:metabolism; D017397:Prefrontal Cortex / Q000378:metabolism*; D017966:Pyramidal Cells / Q000502:physiology; D019718:Receptors, CXCR4 / Q000378:metabolism; D013569:Synapses / Q000502:physiology*; D005680:gamma-Aminobutyric Acid / Q000378:metabolism
chemical_list: D054377:Chemokine CXCL12; C515256:Cxcl12 protein, mouse; D010320:Parvalbumins; D019718:Receptors, CXCR4; D005680:gamma-Aminobutyric Acid
keywords: CXCR4/CXCR7; axon targeting; layer V pyramidal neurons; parvalbumin interneurons; schizophrenia