title: Multicentric Castleman's disease developing during follow-up of sarcoidosis.
abstract: Pulmonary sarcoidosis is reported to have complication of lymphoproliferative disease such as malignant lymphoma, but the complication of multicentric Castleman's disease (MCD) is rarely reported. In our case of a 60-year-old woman, bilateral hilar lymphadenopathy was noted in her chest X-ray. We performed a transbronchial lung biopsy. She was diagnosed as having pulmonary sarcoidosis (Stage II). The shadow on chest X-ray disappeared without treatment. However, after 8 years, swelling of the mediastinal and abdominal lymph node, thickened bronchovascular bundle, and multiple nodular shadows were identified, and a thoracoscopic lung biopsy was performed. Based on the histopathological findings and elevated serum interleukin-6 level (75.7 pg/mL), she was diagnosed with pulmonary sarcoidosis complicated by MCD. When a change in chest X-ray findings are found during monitoring of pulmonary sarcoidosis, it is important to proceed with a thoracoscopic lung biopsy, because of the possibility of the rare complication of MCD.
authors: Division of Pulmonary Medicine, Department of Medicine Jichi Medical University Tochigi Japan.
authors: Tetsuro
authors: T
authors: Sawata
authors: Division of Pulmonary Medicine, Department of Medicine Jichi Medical University Tochigi Japan.
authors: Masashi
authors: M
authors: Bando
authors: Division of Pulmonary Medicine, Department of Medicine Jichi Medical University Tochigi Japan.
authors: Masayuki
authors: M
authors: Nakayama
authors: Division of Pulmonary Medicine, Department of Medicine Jichi Medical University Tochigi Japan.
authors: Naoko
authors: N
authors: Mato
authors: Department of Pathology Japanese Red Cross Medical Center Tokyo Japan.
authors: Tamiko
authors: T
authors: Takemura
authors: Division of Pulmonary Medicine, Department of Medicine Jichi Medical University Tochigi Japan.
authors: Yukihiko
authors: Y
authors: Sugiyama
keywords: Interleukin‐6; multicentric Castleman's disease; sarcoidosis; thoracoscopic lung biopsy