title: Change in Ankle-Brachial Index Over Time in a Screened Japanese Cohort　- The Okinawa Peripheral Arterial Disease Study.
abstract: BACKGROUND
  The temporal change in ankle-brachial index (ABI) in the general population, especially in those aged <40 years, remains unclear.
  
  
  RESULTS
  ABIs of 23,673 individuals were measured in 1-day health checkups between 2003 and 2010. Among them, 1,117 participants aged 28-76 years (mean 53±9 years) whose ABI was measured at least twice within an interval of ≥4 years (mean: 4.9 years) were selected for this study. Baseline ABI was the lowest at age <40 years and increased with age. ABI significantly increased in participants aged <40 and 40-49 years, but not in participants aged 50-59 and ≥60 years. ABI increased in participants with borderline-low baseline ABI (0.9<ABI<1.0, 0.09; P<0.001) and normal baseline ABI (1.0≤ABI<1.2, 0.006; P=0.017). ABI decreased in participants with high-normal baseline ABI (1.2≤ABI<1.4, -0.04; P<0.001). Stepwise multivariate analysis revealed that ABI change was independently associated with baseline ABI (β=-0.566), height (β=0.162), body mass index (β=0.093), and sex (women, β=-0.08).
  
  
  CONCLUSIONS
  ABI was lowest at age <40 years and increased with age. In participants aged <50 years, ABI significantly increased over the mean observation period of 4.9 years. (Circ J 2016; 80: 2004-2009).
authors: Department of Cardiovascular Medicine, Nephrology and Neurology, Graduate School of Medicine, University of the Ryukyu.
authors: Yuichiro
authors: Y
authors: Toma
authors: Akio
authors: A
authors: Ishida
authors: Kozen
authors: K
authors: Kinjo
authors: Yusuke
authors: Y
authors: Ohya
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D055109:Ankle Brachial Index; D044466:Asian People; D015331:Cohort Studies; D005260:Female; D006801:Humans; D007564:Japan; D008297:Male; D008875:Middle Aged; D058729:Peripheral Arterial Disease / Q000503:physiopathology*