title: Low Cerebrospinal Fluid Amyloid-Beta Concentration Is Associated with Poorer Delayed Memory Recall in Women.
abstract: BACKGROUND
  Data on the association of memory performance with cerebrospinal fluid (CSF) biomarkers of Alzheimer's disease (AD) are inconsistent. The Consortium to Establish a Registry for Alzheimer's Disease neuropsychological battery (CERAD-NB) is a commonly used validated cognitive tool; however, only few studies have examined its relationship with CSF biomarkers for AD. We studied the correlation of pathological changes in CSF biomarkers with various CERAD-NB subtests and total scores.
  
  
  METHODS
  Out of 79 subjects (36 men, mean age 70.5 years), 63 had undergone an assessment of cognitive status with CERAD-NB and a CSF biomarker analysis due to a suspected memory disorder, and 16 were controls with no memory complaint.
  
  
  RESULTS
  In women we found a significant correlation between CSF amyloid-beta (Aβ1-42) and several subtests measuring delayed recall. Word List Recall correlated with all markers: Aβ1-42 (r = 0.323, p = 0.035), tau (r = -0.304, p = 0.050) and hyperphosphorylated tau (r = -0.331, p = 0.046). No such correlations were found in men.
  
  
  CONCLUSIONS
  CSF biomarkers correlate with delayed memory scores in CERAD-NB in women, and women may have more actual AD pathology at the time of the investigations than men.
authors: Department of Neurology, Institute of Clinical Medicine, University of Eastern Finland, Finland.
authors: Fanni
authors: F
authors: Haapalinna
authors: Finnish Institute of Occupational Health, Mental Health and Cognition Team, Helsinki, Finland.
authors: Teemu
authors: T
authors: Paajanen
authors: Department of Neurology, Institute of Clinical Medicine, University of Eastern Finland, Finland.
authors: Janne
authors: J
authors: Penttinen
authors: Departments of Anesthesia and Operative Service, Kuopio University Hospital, Kuopio, Finland.
authors: Hannu
authors: H
authors: Kokki
authors: Departments of Anesthesia and Operative Service, Kuopio University Hospital, Kuopio, Finland.
authors: Merja
authors: M
authors: Kokki
authors: Departments of Neurology, Kuopio University Hospital, Kuopio, Finland.
authors: Anne M
authors: AM
authors: Koivisto
authors: Departments of Neurology, Kuopio University Hospital, Kuopio, Finland.
authors: Päivi
authors: P
authors: Hartikainen
authors: Department of Neurology, Institute of Clinical Medicine, University of Eastern Finland, Finland.
authors: Eino
authors: E
authors: Solje
authors: Departments of Neurology, Kuopio University Hospital, Kuopio, Finland.
authors: Tuomo
authors: T
authors: Hänninen
authors: Department of Neurology, Institute of Clinical Medicine, University of Eastern Finland, Finland; Departments of Neurology, Kuopio University Hospital, Kuopio, Finland.
authors: Anne Marja
authors: AM
authors: Remes
authors: Department of Neurology, Institute of Clinical Medicine, University of Eastern Finland, Finland; Departments of Neurology, Kuopio University Hospital, Kuopio, Finland.
authors: Sanna-Kaisa
authors: SK
authors: Herukka
keywords: Alzheimer's disease; CERAD; Cerebrospinal fluid; Cognition; Delayed recall; Mild cognitive impairment; Screening dementia