title: [Not Available].
abstract: BACKGROUND
  Vaspin is a newly-identifi ed adipocytokine associated with insulin resistance (IR).
  
  
  OBJECTIVE
  The aim of this study was to investigate the correlation between plasma vaspin concentrations and IR and determine whether this association is affected by body composition, physical activity and pubertal stage in adolescents.
  
  
  METHODS
  Were studied 484 Brazilian adolescents aged 10-14 years whose anthropometric, clinical, biochemical, and lifestyle measurements were analized. We evaluated the correlation between vaspin and risk factors for IR in adolescents with normal and high body fat percentage (%BF) and did a logistic regression to calculate the odds ratio for IR according to vaspin quartiles sex specifi c for the sample.
  
  
  RESULTS
  Vaspin was positively correlated with IR in adolescents with high %BF (r = 0.23, p = 0.003). The logistic regression analysis adjusted for sex, age, BMI, and pubertal stage showed that adolescents in the 2nd (OR = 0.43, 95% CI = 0.23-0.80, p = 0.008) and 3rd (OR = 0.46, 95% CI = 0.25-0.85, p = 0.014) quartile of vaspin concentration had a lower risk for IR. When the model was adjusted for %BF and physical activity, the association remained statically signifi cant only for adolescents in the 2nd quartile.
  
  
  CONCLUSIONS
  Vaspin was correlated positively with risk factors associated with insulin metabolism in adolescents with high %BF. Vaspin was associated with a reduced risk of IR independently of BMI and pubertal stage and the association was infl uenced by body fat and physical activity in these adolescents.
authors: NUPEB. Federal University of Ouro Preto. Ouro Preto, MG. Brazil. rfreitasmail@gmail.com.
authors: Daniela
authors: D
authors: Pala
authors: Ana Paula
authors: AP
authors: Carlos-Cândido
authors: Larissa
authors: L
authors: Leandro-da-Cruz
authors: Priscila
authors: P
authors: Oliveira-Barbosa
authors: Carla
authors: C
authors: Teixeira-Silva
authors: Ana Carolina
authors: AC
authors: Pinheiro-Volp
authors: George Luiz
authors: GL
authors: Lins-Machado-Coelho
authors: Renata
authors: R
authors: Nascimento-de-Freitas
mesh_terms: D050154:Adiposity / Q000502:physiology*; D000293:Adolescent; D001938:Brazil / Q000453:epidemiology; D002648:Child; D003430:Cross-Sectional Studies; D015444:Exercise; D005260:Female; D006801:Humans; D007333:Insulin Resistance / Q000502:physiology*; D008297:Male; D015843:Serpins / Q000097:blood*
chemical_list: C507339:SERPINA12 protein, human; D015843:Serpins
keywords: Vaspin. Risk factors. Insulin resistance. Physical activity. Body fat.