title: The sulfated polysaccharide from a marine red microalga as a platform for the incorporation of zinc ions.
abstract: The cell-wall sulfated polysaccharide of the marine red microalga Porphyridium sp. is a high molecular weight biopolymer that has potential for use as a platform for metal complexation for various applications. This paper describes the structural and rheological characterization and antibacterial activity of the polysaccharide in combination with Zn(2+) (Zn-PS). SAXS and rheology studies indicate that with the addition of ZnCl2 to the sulfated polysaccharide the only change was the increase in viscosity in the entangled regime. The antibacterial activity of Zn-PS solutions was more potent than that of the native polysaccharide against Gram-negative and Gram-positive bacteria. The synergy between the bioactivities of Zn(2+) (which is a key player in wound healing and is active against variety of pathogens) and the unique bioactivities of the polysaccharide (e.g., anti-inflammatory) indicates promising potential for the development of novel products for the pharmaceutical and cosmetics industries.
authors: Avram and Stella Goldstein-Goren Department of Biotechnology Engineering, Ben-Gurion University of the Negev, P.O. Box 653, Beer-Sheva 84105, Israel.
authors: Gal
authors: G
authors: Netanel Liberman
authors: Department of Chemical Engineering, Ben-Gurion University of the Negev, Beer-Sheva 84105, Israel.
authors: Guy
authors: G
authors: Ochbaum
authors: Avram and Stella Goldstein-Goren Department of Biotechnology Engineering, Ben-Gurion University of the Negev, P.O. Box 653, Beer-Sheva 84105, Israel. Electronic address: arad@bgu.ac.il.
authors: Shoshana
authors: S
authors: Malis Arad
authors: Department of Chemical Engineering, Ben-Gurion University of the Negev, Beer-Sheva 84105, Israel; Ilse Katz Institute for Nanoscale Science and Technology, Ben-Gurion University of the Negev, Beer-Sheva 84105, Israel. Electronic address: rbitton@exchange.bgu.ac.il.
authors: Ronit
authors: R
authors: Bitton
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D003358:Cosmetics / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D006090:Gram-Negative Bacteria / Q000254:growth & development*; D006094:Gram-Positive Bacteria / Q000254:growth & development*; D058086:Microalgae / Q000737:chemistry*; D011134:Polysaccharides / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D000461:Rhodophyta / Q000737:chemistry*; D015032:Zinc / Q000737:chemistry / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D003358:Cosmetics; D011134:Polysaccharides; D015032:Zinc
keywords: Antibacterial activity; Biopolymer; Red microalgae; Rheology; SAXS; Sulfated polysaccharide