title: Comparative Evaluation of Ciprofloxacin Levels in GCF and Plasma of Chronic Periodontitis Patients: Quasi Experimental Study.
abstract: BACKGROUND
  For any antimicrobial approach to be successful in periodontal therapy, it is important that the antimicrobial agent targets the sub-gingival biofilm by attaining sufficient concentration at the sub-gingival site.
  
  
  OBJECTIVE
  The purpose of the present study was to determine and compare the concentrations of ciprofloxacin present in Gingival Crevicular Fluid (GCF) and plasma after its systemic administration.
  
  
  METHODS
  A total of 20 subjects, in the age group of 30-60 years satisfying the inclusion and exclusion criteria, were chosen from the outpatient Department of Periodontology, Government Dental College and Hospital, Hyderabad and consent was obtained. Subjects were put on oral ciprofloxacin therapy (Baycip, Bayer Corporation) of 500mg twice daily doses for five days to establish steady state tissue levels of the agent. GCF and serum samples were collected at the 72(nd) hour after the first dose of ciprofloxacin and were compared using unpaired t test.
  
  
  RESULTS
  The mean gingival index value of the subjects was 1.8 ± 0.59 and the mean probing depth of the subjects taken in the study was 5.724 ± 0.47mm. The results of this study showed that ciprofloxacin concentrations were significantly higher (p<0.001) in GCF than in plasma.
  
  
  CONCLUSIONS
  Results from the present study and those from the earlier studies clearly indicate the ciprofloxacin's ability to reach and concentrate in infected periodontal sites via GCF. This property of ciprofloxacin may be useful for eradication of periodontal pathogens, thus improving the outcome of periodontal therapy.
authors: Reader, Department of Periodontics, Ahmedabad Dental College , Ahmedabad, Gujurat, India .
authors: Madhavi
authors: M
authors: Alamanda
authors: Associate Professor, Department of Periodontics, Bharati Vidyapeeth Deemed University Dental College and Hospital , Sangli, Maharashtra, India .
authors: Sunil Kumar
authors: SK
authors: Denthumdas
authors: Assistant Professor, Department of Public Health Dentistry, Bharati Vidyapeeth Deemed University Dental College and Hospital , Sangli, Maharashtra, India .
authors: Umesh
authors: U
authors: Wadgave
authors: Assistant Professor, Department of Periodontics, Bharati Vidyapeeth Deemed University Dental College and Hospital , Sangli, Maharashtra, India .
authors: Pooja Mohan
authors: PM
authors: Pharne
authors: Assistant Professor, Department of Periodontics, Bharati Vidyapeeth Deemed University Dental College and Hospital , Sangli, Maharashtra, India .
authors: Sandeep Jambukumar
authors: SJ
authors: Patil
authors: Reader, Department of Periodontics, Drs Sudha & Nageswara Rao Siddhartha Institute of Dental Sciences , Chinoutapally, Krishna District, Andhra Pradesh, India .
authors: Sirisha
authors: S
authors: Kondreddi
authors: Assistant Professor, Department of Periodontics, Bharati Vidyapeeth Deemed University Dental College and Hospital , Sangli, Maharashtra, India .
authors: Pavan
authors: P
authors: Deshpande
authors: Professor and Head, Department of Periodontics, Bharati Vidyapeeth Deemed University Dental College and Hospital , Sangli, Maharashtra, India .
authors: Rajesh Suresh
authors: RS
authors: Koppikar
keywords: Antimicrobial; Concentration; Probing depth