title: Near-Infrared Polymeric Nanoparticles with High Content of Cyanine for Bimodal Imaging and Photothermal Therapy.
abstract: The discovery and synthesis of theranostic nanomedicines with high loading of imaging and therapeutic agents is challenging. In this work, a polymer assembling strategy was used to make nanoparticles with exceptionally high loading of theranostic agent. As an example, poly(heptamethine) was synthesized via multicomponent Passerini reaction, and then assembled into nanoparticles in the presence of poly(ethylene glycol)2k-block-poly(d,l-lactide)2k (PEG-PLA) with high heptamethine loading (>50%). The formed nanoparticles could be used for bimodal bioimaging and photothermal therapy. The bimodal bioimaging provided complementary message about biodistribution, and photothermal treatment inhibited the growth of cervical carcinoma upon laser irradiation. This assembly of polymers formed by imaging and therapeutic agents opens new possibilities for the construction of multifunctional nanomedicines.
authors: State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences , 5625 Renmin Street, Changchun, Jilin 130022, P. R. China.|University of Chinese Academy of Sciences , Beijing 100049, P. R. China.
authors: Wenhai
authors: W
authors: Lin
authors: College of Environmental and Chemical Engineering, Yanshan University , Qinhuangdao 060004, P.R. China.
authors: Yang
authors: Y
authors: Li
authors: State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences , 5625 Renmin Street, Changchun, Jilin 130022, P. R. China.|University of Chinese Academy of Sciences , Beijing 100049, P. R. China.
authors: Wei
authors: W
authors: Zhang
authors: State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences , 5625 Renmin Street, Changchun, Jilin 130022, P. R. China.
authors: Shi
authors: S
authors: Liu
authors: State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences , 5625 Renmin Street, Changchun, Jilin 130022, P. R. China.
authors: Zhigang
authors: Z
authors: Xie
authors: State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences , 5625 Renmin Street, Changchun, Jilin 130022, P. R. China.
authors: Xiabin
authors: X
authors: Jing
mesh_terms: D004396:Coloring Agents; D053758:Nanoparticles; D010789:Phototherapy; D011108:Polymers; D000068936:Theranostic Nanomedicine; D014018:Tissue Distribution
chemical_list: D004396:Coloring Agents; D011108:Polymers
keywords: fluorescence imaging; near-infrared; photoacoustic imaging; photothermal therapy