title: Intraindividual Comparison of Everolimus-Eluting Bioresorbable Vascular Scaffolds Versus Drug-Eluting Metallic Stents.
abstract: The performance of everolimus-eluting bioresorbable vascular scaffold (BVS) versus drug-eluting metallic stent (DES) in the same individual receiving multilesion percutaneous coronary intervention (PCI) remains poorly studied. This report investigates the intraindividual performance of BVS and DES in patients receiving multilesion PCI and follow-up angiography.
  
  
  
  Data of patients undergoing BVS implantation for de novo lesions from 2012 to 2014 at 2 centers in Munich, Germany, were prospectively collected. Individuals receiving multilesion PCI with BVS and DES and follow-up angiography at 6 to 8 months were studied. Primary end point was in-device late lumen loss. Secondary end points were binary restenosis, target lesion revascularization, and definite stent/scaffold thrombosis. A total of 90 PCI patients with 239 lesions received BVS (n=112) and DES (n=127). Follow-up angiography after a median of 6.6 months (5.8-7.1) showed a higher degree of late lumen loss in lesions treated with BVS versus DES (0.30±0.59 versus 0.22±0.48 mm; P=0.035). However, the adjustment for baseline angiographic imbalances discarded an influence of stent type on late lumen loss (P=0.82). At the same time point, binary restenosis was comparable between BVS and DES (7.8% versus 8.9%; P=0.90). After a median of 13.2 months (9.2-17.6), target lesion revascularization (9.8% versus 10.2%; P=0.97) and definite stent/scaffold thrombosis (2.7% versus 1.6%; P=0.48) did not differ between BVS and DES.
  
  
  
  In patients receiving multilesion PCI, BVS displays acceptable intraindividual performance compared with DES. Larger trials, extended follow-up, and continuous device iteration remain essential to improve BVS technology.
authors: From the Deutsches Herzzentrum München, Technische Universität München, Germany (S.C., S.K., R.A.B., J.W., R.C., D.G., Y.H., H.S., M.F., A.K.); 1. med. Klinik, Klinikum rechts der Isar, Technische Universität München, Germany (P.H., K.-L.L.); and DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance (K.-L.L., H.S., A.K.). cassese@dhm.mhn.de.
authors: Salvatore
authors: S
authors: Cassese
authors: From the Deutsches Herzzentrum München, Technische Universität München, Germany (S.C., S.K., R.A.B., J.W., R.C., D.G., Y.H., H.S., M.F., A.K.); 1. med. Klinik, Klinikum rechts der Isar, Technische Universität München, Germany (P.H., K.-L.L.); and DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance (K.-L.L., H.S., A.K.).
authors: Petra
authors: P
authors: Hoppmann
authors: From the Deutsches Herzzentrum München, Technische Universität München, Germany (S.C., S.K., R.A.B., J.W., R.C., D.G., Y.H., H.S., M.F., A.K.); 1. med. Klinik, Klinikum rechts der Isar, Technische Universität München, Germany (P.H., K.-L.L.); and DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance (K.-L.L., H.S., A.K.).
authors: Sebastian
authors: S
authors: Kufner
authors: From the Deutsches Herzzentrum München, Technische Universität München, Germany (S.C., S.K., R.A.B., J.W., R.C., D.G., Y.H., H.S., M.F., A.K.); 1. med. Klinik, Klinikum rechts der Isar, Technische Universität München, Germany (P.H., K.-L.L.); and DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance (K.-L.L., H.S., A.K.).
authors: Robert A
authors: RA
authors: Byrne
authors: From the Deutsches Herzzentrum München, Technische Universität München, Germany (S.C., S.K., R.A.B., J.W., R.C., D.G., Y.H., H.S., M.F., A.K.); 1. med. Klinik, Klinikum rechts der Isar, Technische Universität München, Germany (P.H., K.-L.L.); and DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance (K.-L.L., H.S., A.K.).
authors: Jens
authors: J
authors: Wiebe
authors: From the Deutsches Herzzentrum München, Technische Universität München, Germany (S.C., S.K., R.A.B., J.W., R.C., D.G., Y.H., H.S., M.F., A.K.); 1. med. Klinik, Klinikum rechts der Isar, Technische Universität München, Germany (P.H., K.-L.L.); and DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance (K.-L.L., H.S., A.K.).
authors: Roisin
authors: R
authors: Colleran
authors: From the Deutsches Herzzentrum München, Technische Universität München, Germany (S.C., S.K., R.A.B., J.W., R.C., D.G., Y.H., H.S., M.F., A.K.); 1. med. Klinik, Klinikum rechts der Isar, Technische Universität München, Germany (P.H., K.-L.L.); and DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance (K.-L.L., H.S., A.K.).
authors: Daniele
authors: D
authors: Giacoppo
authors: From the Deutsches Herzzentrum München, Technische Universität München, Germany (S.C., S.K., R.A.B., J.W., R.C., D.G., Y.H., H.S., M.F., A.K.); 1. med. Klinik, Klinikum rechts der Isar, Technische Universität München, Germany (P.H., K.-L.L.); and DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance (K.-L.L., H.S., A.K.).
authors: Yukinori
authors: Y
authors: Harada
authors: From the Deutsches Herzzentrum München, Technische Universität München, Germany (S.C., S.K., R.A.B., J.W., R.C., D.G., Y.H., H.S., M.F., A.K.); 1. med. Klinik, Klinikum rechts der Isar, Technische Universität München, Germany (P.H., K.-L.L.); and DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance (K.-L.L., H.S., A.K.).
authors: Karl-Ludwig
authors: KL
authors: Laugwitz
authors: From the Deutsches Herzzentrum München, Technische Universität München, Germany (S.C., S.K., R.A.B., J.W., R.C., D.G., Y.H., H.S., M.F., A.K.); 1. med. Klinik, Klinikum rechts der Isar, Technische Universität München, Germany (P.H., K.-L.L.); and DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance (K.-L.L., H.S., A.K.).
authors: Heribert
authors: H
authors: Schunkert
authors: From the Deutsches Herzzentrum München, Technische Universität München, Germany (S.C., S.K., R.A.B., J.W., R.C., D.G., Y.H., H.S., M.F., A.K.); 1. med. Klinik, Klinikum rechts der Isar, Technische Universität München, Germany (P.H., K.-L.L.); and DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance (K.-L.L., H.S., A.K.).
authors: Massimiliano
authors: M
authors: Fusaro
authors: From the Deutsches Herzzentrum München, Technische Universität München, Germany (S.C., S.K., R.A.B., J.W., R.C., D.G., Y.H., H.S., M.F., A.K.); 1. med. Klinik, Klinikum rechts der Isar, Technische Universität München, Germany (P.H., K.-L.L.); and DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance (K.-L.L., H.S., A.K.).
authors: Adnan
authors: A
authors: Kastrati
mesh_terms: D000368:Aged; D017023:Coronary Angiography; D054855:Drug-Eluting Stents; D000068338:Everolimus / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D062645:Percutaneous Coronary Intervention / Q000295:instrumentation / Q000379:methods*; D011446:Prospective Studies; D015607:Stents; D054457:Tissue Scaffolds
chemical_list: D000068338:Everolimus
keywords: angiography; bioresorbable vascular scaffold; coronary artery disease; drug-eluting stent; everolimus; percutaneous coronary intervention