title: Solid lipid nanoparticles as attractive drug vehicles: Composition, properties and therapeutic strategies.
abstract: This work briefly reviews up-to-date developments in solid lipid nanoparticles (SLNs) as effective nanocolloidal system for drug delivery. It summarizes SLNs in terms of their preparation, surface modification and properties. The application of SLNs as a carrier system enables to improve the therapeutic efficacy of drugs from various therapeutic groups. Present uses of SLNs include cancer therapy, dermatology, bacterial infections, brain targeting and eye disorders among others. The usage of SLNs provides enhanced pharmacokinetic properties and modulated release of drugs. SLN ubiquitous application results from their specific features such as possibility of surface modification, increased permeation through biological barriers, resistance to chemical degradation, possibility of co-delivery of various therapeutic agents or stimuli-responsiveness. This paper will be useful to the scientists working in the domain of SLN-based drug delivery systems.
authors: NanoBioMedical Centre, Adam Mickiewicz University, Umultowska 85, 61-614 Poznań, Poland. Electronic address: Malgorzata.Geszke-Moritz@amu.edu.pl.
authors: Małgorzata
authors: M
authors: Geszke-Moritz
authors: Poznan University of Technology, Faculty of Chemical Technology, Institute of Chemistry and Technical Electrochemistry, Berdychowo 4, 60-965 Poznań, Poland. Electronic address: michal.moritz@put.poznan.pl.
authors: Michał
authors: M
authors: Moritz
mesh_terms: D001424:Bacterial Infections / Q000188:drug therapy; D001927:Brain Diseases / Q000188:drug therapy; D004337:Drug Carriers / Q000737:chemistry / Q000627:therapeutic use; D005128:Eye Diseases / Q000188:drug therapy; D008055:Lipids / Q000737:chemistry / Q000627:therapeutic use; D053758:Nanoparticles / Q000737:chemistry*; D009369:Neoplasms / Q000188:drug therapy; D012871:Skin Diseases / Q000188:drug therapy
chemical_list: D004337:Drug Carriers; D008055:Lipids
keywords: Drug delivery systems; Lipids; Nanocolloidal carriers; Pharmacokinetics; Solid lipid nanoparticles; Therapeutic agents