title: From Krebs to clinic: glutamine metabolism to cancer therapy.
abstract: The resurgence of research into cancer metabolism has recently broadened interests beyond glucose and the Warburg effect to other nutrients, including glutamine. Because oncogenic alterations of metabolism render cancer cells addicted to nutrients, pathways involved in glycolysis or glutaminolysis could be exploited for therapeutic purposes. In this Review, we provide an updated overview of glutamine metabolism and its involvement in tumorigenesis in vitro and in vivo, and explore the recent potential applications of basic science discoveries in the clinical setting.
authors: Abramson Family Cancer Research Institute, University of Pennsylvania.|Abramson Cancer Center, University of Pennsylvania.|Division of Hematology-Oncology, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
authors: Brian J
authors: BJ
authors: Altman
authors: Abramson Family Cancer Research Institute, University of Pennsylvania.|Abramson Cancer Center, University of Pennsylvania.|Division of Hematology-Oncology, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
authors: Zachary E
authors: ZE
authors: Stine
authors: Abramson Family Cancer Research Institute, University of Pennsylvania.|Abramson Cancer Center, University of Pennsylvania.|Division of Hematology-Oncology, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
authors: Chi V
authors: CV
authors: Dang
mesh_terms: D000255:Adenosine Triphosphate / Q000378:metabolism; D002952:Citric Acid Cycle; D005973:Glutamine / Q000378:metabolism*; D005977:Glutarates / Q000378:metabolism; D006801:Humans; D009369:Neoplasms / Q000628:therapy*
chemical_list: D005977:Glutarates; D005973:Glutamine; D000255:Adenosine Triphosphate; C035736:glutaric acid