title: Keratins Are Going Nuclear.
abstract: Previously thought to reside exclusively in the cytoplasm, the cytoskeletal protein keratin 17 (K17) has been recently identified inside the nucleus of tumor epithelial cells with a direct impact on cell proliferation and gene expression. We comment on fundamental questions raised by this new finding and the associated significance.
authors: Department of Biochemistry and Molecular Biology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA.
authors: Ryan P
authors: RP
authors: Hobbs
authors: Department of Biochemistry and Molecular Biology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA.
authors: Justin T
authors: JT
authors: Jacob
authors: Department of Biochemistry and Molecular Biology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA; Department of Biological Chemistry, School of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA; Department of Oncology, School of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA; Department of Dermatology, School of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA; The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, MD 21205, USA. Electronic address: coulombe@jhu.edu.
authors: Pierre A
authors: PA
authors: Coulombe
mesh_terms: D002467:Cell Nucleus / Q000378:metabolism*; D049109:Cell Proliferation; D004847:Epithelial Cells / Q000378:metabolism*; D006801:Humans; D007633:Keratins / Q000378:metabolism*
chemical_list: D007633:Keratins