title: Persistent aggregates in apheresis platelet concentrates are commonly collected from donors with a history of aggregate donation.
abstract: Platelet apheresis sometimes causes persistent aggregates (PA). This study (n = 211) shows that changing the apheresis settings to reach fixed product volumes instead of yields does not influence PA incidence, even though PA products on average contain more platelets than controls. Furthermore, logistic regression was used to model if PA can be predicted on the basis of certain predonation parameters. PA donation history was the only parameter retained, proving a strong determinant of predictability [AUC = 0.735 (SE = 0.022)]. Consequently, donations from a donor with previous PA history are 7.8 times more likely to contain PA than from a donor without preceding history.
authors: Transfusion Research Center, Belgian Red Cross-Flanders, Ghent, Belgium.
authors: H B
authors: http://orcid.org/0000-0003-0052-8852
authors: HB
authors: Feys
authors: Department of Public Health and Primary Care, KU Leuven, KULAK, Kortrijk, Belgium.
authors: H
authors: H
authors: Pottel
authors: Blood Service of the Belgian Red Cross-Flanders, Mechelen, Belgium.
authors: J
authors: J
authors: Coene
authors: Blood Service of the Belgian Red Cross-Flanders, Mechelen, Belgium.
authors: G
authors: G
authors: Vandewalle
authors: Blood Service of the Belgian Red Cross-Flanders, Mechelen, Belgium.|Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium.|Department of Public Health and Primary Care, KU Leuven, Leuven, Belgium.
authors: P
authors: P
authors: Vandekerckhove
authors: Transfusion Research Center, Belgian Red Cross-Flanders, Ghent, Belgium.|Blood Service of the Belgian Red Cross-Flanders, Mechelen, Belgium.|Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium.
authors: V
authors: V
authors: Compernolle
mesh_terms: D001782:Blood Donors; D001792:Blood Platelets / Q000502:physiology*; D006801:Humans; D010974:Platelet Aggregation; D053657:Platelet-Rich Plasma / Q000166:cytology; D010983:Plateletpheresis
keywords: Blood collection; Platelet concentrates; apheresis - donation