title: Bi-directional controlled release of ibuprofen and Mg(2+) from magnesium alloys coated by multifunctional composite.
abstract: Two major problems for magnesium alloy implant are the high degradation rate and easy infection associated with implantation. Herein, a surface drug delivery system (Mg/Epoxy resin-ZnO/PCL-Ibuprofen) which can realize bi-directional controlled release of ibuprofen and Mg(2+) was designed via a dip coating process followed by spraying. The in vitro test demonstrated that the ibuprofen in drug-eluting compound material showed sustained release profiles for 22days, which can effectively solve the local cellular rejection and inflammation during the early stage of implantation. Besides, the drug carrier also exhibited improved corrosion resistance duel to the high combining strength between Epoxy resin-ZnO coating and magnesium alloy, so Mg(2+) can release slowly at first and then speeded up later. This approach may be suitable for coating other implant materials such as stainless steel, titanium alloy etc.
authors: School of Chemistry and Chemical Engineering, Southwest University, Chongqing 400715, PR China.
authors: Hongzhou
authors: H
authors: Dong
authors: School of Chemistry and Chemical Engineering, Southwest University, Chongqing 400715, PR China. Electronic address: liqingswu@163.com.
authors: Qing
authors: Q
authors: Li
authors: School of Chemistry and Chemical Engineering, Southwest University, Chongqing 400715, PR China.
authors: Cui
authors: C
authors: Tan
authors: School of Chemistry and Chemical Engineering, Southwest University, Chongqing 400715, PR China.
authors: Ningning
authors: N
authors: Bai
authors: Faculty of Materials and Energy, Southwest University, Chongqing 400715, PR China.
authors: Peng
authors: P
authors: Cai
mesh_terms: D000497:Alloys / Q000737:chemistry / Q000493:pharmacokinetics; D020099:Coated Materials, Biocompatible / Q000737:chemistry / Q000493:pharmacokinetics; D003692:Delayed-Action Preparations / Q000737:chemistry / Q000493:pharmacokinetics; D007052:Ibuprofen / Q000737:chemistry / Q000493:pharmacokinetics; D008274:Magnesium / Q000737:chemistry / Q000493:pharmacokinetics
chemical_list: D000497:Alloys; D020099:Coated Materials, Biocompatible; D003692:Delayed-Action Preparations; D008274:Magnesium; D007052:Ibuprofen
keywords: Corrosion resistance; Drug release; Magnesium alloy; Nano-composite