title: In vitro and in vivo corrosion and histocompatibility of pure Mg and a Mg-6Zn alloy as urinary implants in rat model.
abstract: Pure Mg and a Mg-6wt.% Zn alloy were investigated as potential candidates for biodegradable implants for the urinary system. The in vitro corrosion behavior was studied by potentiodynamic polarization and immersion tests in simulated body fluid (SBF) at 37°C. The in vivo degradation and histocompatibility were examined through implantation into the bladders of Wistar rats. The alloying element Zn elevated the passivation potential and increased the cathodic current density. Both in vitro and in vivo degradation tests showed a faster corrosion rate for the Mg-6Zn alloy. Tissues stained with hematoxylin and eosin (HE) suggested that both pure Mg and Mg-6Zn alloy exhibited good histocompatibility in the bladder indwelling implantation and no differences between pure Mg and Mg-6Zn groups were found in bladder, liver and kidney tissues during the 2weeks implantation. Overall, this work presented instructive information on the degradation properties and histocompatibility of pure Mg and the Mg-6Zn alloy in the urinary system.
authors: Department of Urology, Air Force General Hospital, 30 Fucheng Road, Haidian District, Beijing 100142, China; Key Laboratory of Aerospace Advanced Materials and Performance (Beihang University), Ministry of Education, Beijing 100191, China.
authors: Shiying
authors: S
authors: Zhang
authors: School of Materials Science and Engineering, Beihang University, Beijing 100191, China; Key Laboratory of Aerospace Advanced Materials and Performance (Beihang University), Ministry of Education, Beijing 100191, China.
authors: Yang
authors: Y
authors: Zheng
authors: Department of Urology, Air Force General Hospital, 30 Fucheng Road, Haidian District, Beijing 100142, China.
authors: Liming
authors: L
authors: Zhang
authors: School of Materials Science and Engineering, Beihang University, Beijing 100191, China; Key Laboratory of Aerospace Advanced Materials and Performance (Beihang University), Ministry of Education, Beijing 100191, China.
authors: Yanze
authors: Y
authors: Bi
authors: Department of Urology, Air Force General Hospital, 30 Fucheng Road, Haidian District, Beijing 100142, China.
authors: Jianye
authors: J
authors: Li
authors: School of Materials Science and Engineering, Beihang University, Beijing 100191, China; Key Laboratory of Aerospace Advanced Materials and Performance (Beihang University), Ministry of Education, Beijing 100191, China.
authors: Jiao
authors: J
authors: Liu
authors: Department of Urology, Air Force General Hospital, 30 Fucheng Road, Haidian District, Beijing 100142, China.
authors: Youbin
authors: Y
authors: Yu
authors: Department of Urology, Air Force General Hospital, 30 Fucheng Road, Haidian District, Beijing 100142, China. Electronic address: Guoheqing777@163.com.
authors: Heqing
authors: H
authors: Guo
authors: School of Materials Science and Engineering, Beihang University, Beijing 100191, China; Beijing Key Laboratory for Advanced Functional Materials and Thin Film Technology (Beihang University), Beijing 100191, China. Electronic address: liyan@buaa.edu.cn.
authors: Yan
authors: Y
authors: Li
mesh_terms: D020341:Absorbable Implants; D000497:Alloys / Q000493:pharmacokinetics / Q000494:pharmacology; D000818:Animals; D003343:Corrosion; D006801:Humans; D007668:Kidney / Q000378:metabolism; D008274:Magnesium / Q000493:pharmacokinetics / Q000494:pharmacology; D008297:Male; D008422:Materials Testing; D051381:Rats; D017208:Rats, Wistar; D015032:Zinc / Q000493:pharmacokinetics / Q000494:pharmacology
chemical_list: D000497:Alloys; D008274:Magnesium; D015032:Zinc
keywords: Degradation; In vivo histocompatibility; Magnesium alloy; Urinary implants