title: Palladium-Catalyzed Enantioselective Three-Component Synthesis of α-Arylglycines.
abstract: A general Pd-catalyzed, enantioselective three-component synthesis of α-arylglycines starting from sulfonamides, glyoxylic acid derivatives, and boronic acids was developed. This operationally straightforward procedure enables the preparation of a wide variety of α-arylglycines in high yields and excellent levels of enantioselectivity from a simple set of readily available starting materials. Incorporation of Pbf-amides gives a racemization-free access to N-unprotected α-arylglycines.
authors: Department of Organic Chemistry and Chemical Biology, Goethe-University Frankfurt am Main , Max-von-Laue-Strasse 7, 60438 Frankfurt am Main, Germany.
authors: Tamara
authors: T
authors: Beisel
authors: Department of Organic Chemistry and Chemical Biology, Goethe-University Frankfurt am Main , Max-von-Laue-Strasse 7, 60438 Frankfurt am Main, Germany.
authors: Andreas M
authors: AM
authors: Diehl
authors: Department of Organic Chemistry and Chemical Biology, Goethe-University Frankfurt am Main , Max-von-Laue-Strasse 7, 60438 Frankfurt am Main, Germany.
authors: Georg
authors: G
authors: Manolikakes