title: Facile Synthesis of Azaarene-Substituted Hydroxycoumarins Possessing High Biological Activities via Three-Component C(sp(3))-H Functionalization.
abstract: An unprecedented three-component C(sp(3))-H functionalization of 2-alkylazaarenes with aryl aldehydes and 4-hydroxycoumarins was realized, providing azaarene-substituted 3-benzyl-4-hydroxycoumarins in good to excellent yields. These new target compounds displayed broad-spectrum antibacterial activities, providing a new type of antibacterial skeleton.
authors: College of Chemistry and Pharmaceutical Sciences, Qingdao Agricultural University , Qingdao 266109, China.
authors: Haoxun
authors: H
authors: Dong
authors: College of Chemistry and Pharmaceutical Sciences, Qingdao Agricultural University , Qingdao 266109, China.
authors: Lubin
authors: L
authors: Xu
authors: College of Chemistry and Pharmaceutical Sciences, Qingdao Agricultural University , Qingdao 266109, China.
authors: Shuai-Shuai
authors: SS
authors: Li
authors: College of Chemistry and Pharmaceutical Sciences, Qingdao Agricultural University , Qingdao 266109, China.
authors: Liang
authors: L
authors: Wang
authors: Key Laboratory of Marine Drugs, The Ministry of Education of China, School of Medicine and Pharmacy, Ocean University of China , Qingdao 266003, China.
authors: Chang-Lun
authors: CL
authors: Shao
authors: College of Chemistry and Pharmaceutical Sciences, Qingdao Agricultural University , Qingdao 266109, China.
authors: Jian
authors: J
authors: Xiao
mesh_terms: D015110:4-Hydroxycoumarins / Q000138:chemical synthesis* / Q000494:pharmacology*; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D001412:Bacillus subtilis / Q000187:drug effects; D001419:Bacteria / Q000187:drug effects*; D020650:Combinatorial Chemistry Techniques; D056569:Enterococcaceae / Q000187:drug effects; D006801:Humans; D008835:Micrococcaceae / Q000187:drug effects; D015394:Molecular Structure; D013212:Staphylococcus epidermidis / Q000187:drug effects; D013237:Stereoisomerism; D013329:Structure-Activity Relationship; D014736:Vibrio parahaemolyticus / Q000187:drug effects
chemical_list: D015110:4-Hydroxycoumarins; D000900:Anti-Bacterial Agents
keywords: 2-alkylazaarenes; 3-benzyl-4-hydroxycoumarins; 4-hydroxycoumarins; C(sp3)−H functionalization; aryl aldehydes; biological activities; three-component