title: The cytotoxic T lymphocyte immune synapse at a glance.
abstract: The immune synapse provides an important structure for communication with immune cells. Studies on immune synapses formed by cytotoxic T lymphocytes (CTLs) highlight the dynamic changes and specialised mechanisms required to facilitate focal signalling and polarised secretion in immune cells. In this Cell Science at a Glance article and the accompanying poster, we illustrate the different steps that reveal the specialised mechanisms used to focus secretion at the CTL immune synapse and allow CTLs to be such efficient and precise serial killers.
authors: Cambridge Institute for Medical Research, Biomedical Campus, Cambridge CB2 0XY, UK.
authors: Nele M G
authors: NM
authors: Dieckmann
authors: Cambridge Institute for Medical Research, Biomedical Campus, Cambridge CB2 0XY, UK.
authors: Gordon L
authors: GL
authors: Frazer
authors: Cambridge Institute for Medical Research, Biomedical Campus, Cambridge CB2 0XY, UK.
authors: Yukako
authors: Y
authors: Asano
authors: Cambridge Institute for Medical Research, Biomedical Campus, Cambridge CB2 0XY, UK.
authors: Jane C
authors: JC
authors: Stinchcombe
authors: Cambridge Institute for Medical Research, Biomedical Campus, Cambridge CB2 0XY, UK gg305@cam.ac.uk.
authors: Gillian M
authors: 0000-0003-0434-5842
authors: GM
authors: Griffiths
mesh_terms: D000818:Animals; D002462:Cell Membrane / Q000378:metabolism; D002923:Cilia / Q000378:metabolism; D006801:Humans; D054992:Immunological Synapses / Q000378:metabolism*; D011948:Receptors, Antigen, T-Cell / Q000378:metabolism; D015398:Signal Transduction; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology*
chemical_list: D011948:Receptors, Antigen, T-Cell
keywords: Cytotoxic T lymphocyte; Immune synapse; Secretion