title: [New Progress of MALDI-TOF-IMS in the Study of Proteomics].
abstract: Matrix-assisted laser desorption/ionization time-of-flight imaging mass spectrometry (MALDI-TOF-IMS) has been a classical technique for studying proteomics in present and a tool for analyzing the distribution of proteins and small molecules within biological tissue sections. MALDI-TOF-IMS can analyze multiple unknown compounds in biological tissue sections simultaneously through a single measurement which can obtain molecule imaging of the tissue while maintaining the integrity of cellular and molecules in tissue. In recent years, imaging mass spectrometry technique develops relatively quickly in all biomedical domain. This paper based on the relevant data and reviews the present developing level of MALDI-TOF-IMS, the principle of imaging mass spectrometry, methology and the prospect in forensic pathology.
authors: Guan-heng
authors: GH
authors: Ren
authors: Rong-hua
authors: RH
authors: Weng
authors: Yan
authors: Y
authors: Shi
authors: Ping
authors: P
authors: Huang
authors: Zheng-dong
authors: ZD
authors: Li
authors: Yu
authors: Y
authors: Shao
authors: Kai-fei
authors: KF
authors: Deng
authors: Ning-guo
authors: NG
authors: Liu
authors: Yi-jiu
authors: YJ
authors: Chen
mesh_terms: D003952:Diagnostic Imaging; D044707:Forensic Sciences / Q000379:methods*; D006801:Humans; D008297:Male; D011506:Proteins; D040901:Proteomics; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
chemical_list: D011506:Proteins