title: Propolis: a potential natural product to fight Candida species infections.
abstract: To evaluate the effect of propolis against Candida species planktonic cells and its counterpart's biofilms.
  
  
  
  The MIC values, time-kill curves and filamentation form inhibition were determined in Candida planktonic cells. The effect of propolis on Candida biofilms was assessed through quantification of CFUs.
  
  
  
  MIC values, ranging from 220 to 880 µg/ml, demonstrated higher efficiency on C. albicans and C. parapsilosis than on C. tropicalis cells. In addition, propolis was able to prevent Candida species biofilm's formation and eradicate their mature biofilms, coupled with a significant reduction on C. tropicalis and C. albicans filamentation.
  
  
  
  Propolis is an inhibitor of Candida virulence factors and represents an innovative alternative to fight candidiasis.
authors: Laboratory of Medical Mycology, Department of Clinical Analysis & Biomedicine, Universidade Estadual de Maringá, Maringá, PR, Brazil.|CEB - Centre of Biological Engineering, Universidade do Minho, Braga, Portugal.|CAPES Foundation, Ministry of Education of Brazil, Brasilia - DF 70.040-020, Brazil.|Laboratory of Research & Development of Drug Delivery Systems, Department of Pharmacy, Universidade Estadual de Maringá, Maringá, PR, Brazil.
authors: Flávia K
authors: FK
authors: Tobaldini-Valerio
authors: Laboratory of Medical Mycology, Department of Clinical Analysis & Biomedicine, Universidade Estadual de Maringá, Maringá, PR, Brazil.|CEB - Centre of Biological Engineering, Universidade do Minho, Braga, Portugal.|CAPES Foundation, Ministry of Education of Brazil, Brasilia - DF 70.040-020, Brazil.|Laboratory of Research & Development of Drug Delivery Systems, Department of Pharmacy, Universidade Estadual de Maringá, Maringá, PR, Brazil.
authors: Patricia S
authors: PS
authors: Bonfim-Mendonça
authors: Laboratory of Medical Mycology, Department of Clinical Analysis & Biomedicine, Universidade Estadual de Maringá, Maringá, PR, Brazil.|CEB - Centre of Biological Engineering, Universidade do Minho, Braga, Portugal.|CAPES Foundation, Ministry of Education of Brazil, Brasilia - DF 70.040-020, Brazil.|Laboratory of Research & Development of Drug Delivery Systems, Department of Pharmacy, Universidade Estadual de Maringá, Maringá, PR, Brazil.
authors: Helen C
authors: HC
authors: Rosseto
authors: Laboratory of Medical Mycology, Department of Clinical Analysis & Biomedicine, Universidade Estadual de Maringá, Maringá, PR, Brazil.|CEB - Centre of Biological Engineering, Universidade do Minho, Braga, Portugal.|CAPES Foundation, Ministry of Education of Brazil, Brasilia - DF 70.040-020, Brazil.|Laboratory of Research & Development of Drug Delivery Systems, Department of Pharmacy, Universidade Estadual de Maringá, Maringá, PR, Brazil.
authors: Marcos L
authors: ML
authors: Bruschi
authors: Laboratory of Medical Mycology, Department of Clinical Analysis & Biomedicine, Universidade Estadual de Maringá, Maringá, PR, Brazil.|CEB - Centre of Biological Engineering, Universidade do Minho, Braga, Portugal.|CAPES Foundation, Ministry of Education of Brazil, Brasilia - DF 70.040-020, Brazil.|Laboratory of Research & Development of Drug Delivery Systems, Department of Pharmacy, Universidade Estadual de Maringá, Maringá, PR, Brazil.
authors: Mariana
authors: M
authors: Henriques
authors: Laboratory of Medical Mycology, Department of Clinical Analysis & Biomedicine, Universidade Estadual de Maringá, Maringá, PR, Brazil.|CEB - Centre of Biological Engineering, Universidade do Minho, Braga, Portugal.|CAPES Foundation, Ministry of Education of Brazil, Brasilia - DF 70.040-020, Brazil.|Laboratory of Research & Development of Drug Delivery Systems, Department of Pharmacy, Universidade Estadual de Maringá, Maringá, PR, Brazil.
authors: Melyssa
authors: M
authors: Negri
authors: Laboratory of Medical Mycology, Department of Clinical Analysis & Biomedicine, Universidade Estadual de Maringá, Maringá, PR, Brazil.|CEB - Centre of Biological Engineering, Universidade do Minho, Braga, Portugal.|CAPES Foundation, Ministry of Education of Brazil, Brasilia - DF 70.040-020, Brazil.|Laboratory of Research & Development of Drug Delivery Systems, Department of Pharmacy, Universidade Estadual de Maringá, Maringá, PR, Brazil.
authors: Sonia
authors: S
authors: Silva
authors: Laboratory of Medical Mycology, Department of Clinical Analysis & Biomedicine, Universidade Estadual de Maringá, Maringá, PR, Brazil.|CEB - Centre of Biological Engineering, Universidade do Minho, Braga, Portugal.|CAPES Foundation, Ministry of Education of Brazil, Brasilia - DF 70.040-020, Brazil.|Laboratory of Research & Development of Drug Delivery Systems, Department of Pharmacy, Universidade Estadual de Maringá, Maringá, PR, Brazil.
authors: Terezinha Ie
authors: TIe
authors: Svidzinski
mesh_terms: D000935:Antifungal Agents / Q000494:pharmacology*; D018441:Biofilms / Q000187:drug effects; D001688:Biological Products / Q000494:pharmacology*; D002175:Candida / Q000187:drug effects* / Q000235:genetics / Q000502:physiology; D002177:Candidiasis / Q000382:microbiology*; D025141:Drug Resistance, Fungal; D005656:Fungal Proteins / Q000235:genetics / Q000378:metabolism; D008826:Microbial Sensitivity Tests; D011429:Propolis / Q000494:pharmacology*; D037521:Virulence Factors / Q000235:genetics / Q000378:metabolism
chemical_list: D000935:Antifungal Agents; D001688:Biological Products; D005656:Fungal Proteins; D037521:Virulence Factors; D011429:Propolis
keywords: Candida species; biofilm; propolis extract; virulence factors