title: Photocatalytic Generation of 2-Azolyl Radicals: Intermediates for the Azolylation of Arenes and Heteroarenes via C-H Functionalization.
abstract: The 2-azolyl radical, generated from 2-bromoazoles via photocatalysis, is a powerful intermediate for the intermolecular arylation of unmodified (hetero)arenes. The reaction is characterized by mild conditions, operational simplicity, tolerance toward functional and sterically demanding groups, broad scope, and anti-Minisci selectivity. A working mechanism is provided, and a low-solubility amine is essential for successful coupling. The utility of the reaction is demonstrated via late-stage functionalization of methyl estrone and application toward other bromoarenes.
authors: Department of Chemistry, Oklahoma State University , Stillwater, Oklahoma 74078, United States.
authors: Amandeep
authors: A
authors: Arora
authors: Department of Chemistry, Oklahoma State University , Stillwater, Oklahoma 74078, United States.
authors: Jimmie D
authors: JD
authors: Weaver