title: β-eudesmol, a sesquiterpene from Teucrium ramosissimum, inhibits superoxide production, proliferation, adhesion and migration of human tumor cell.
abstract: Reactive oxygen species are well-known mediators of various biological responses. Recently, new homologues of the catalytic subunit of NADPH oxidase have been discovered in non phagocytic cells. These new homologues (Nox1-Nox5) produce low levels of superoxides compared to the phagocytic homologue Nox2/gp91phox. In this study we examined the effect of β-eudesmol, a sesquiterpenoid alcohol isolated from Teucrium ramosissimum leaves, on proliferation, superoxide anion production, adhesion and migration of human lung (A549) and colon (HT29 and Caco-2) cancer cell lines. Proliferation of tumor cells was inhibited by β-eudesmol. It also significantly inhibited superoxide production in A549 cells. Furthermore, β-eudesmol inhibited adhesion and migration of A549 and HT29 cell. These results demonstrate that β-eudesmol may be a novel anticancer agent for the treatment of lung and colon cancer by different ways: by inhibition of superoxide production or by blocking proliferation, adhesion and migration.
authors: Laboratory for Forest Ecology, National Institute for Research in Rural Engineering, Water and Forests, University of carthage, BP 10, 2080 Ariana, Tunisie. Electronic address: medbensghaier.inrgref@gmail.com.
authors: Mohamed
authors: M
authors: Ben Sghaier
authors: Centre de Recherche en Oncologie Biologique et Oncopharmacologie (CRO2), INSERM UMR 911, Faculté de Pharmacie, Marseille, France; Aix-Marseille Université, France.
authors: Mohamed
authors: M
authors: Mousslim
authors: Centre de Recherche en Oncologie Biologique et Oncopharmacologie (CRO2), INSERM UMR 911, Faculté de Pharmacie, Marseille, France; Aix-Marseille Université, France.
authors: Alessandra
authors: A
authors: Pagano
authors: Laboratory for Forest Ecology, National Institute for Research in Rural Engineering, Water and Forests, University of carthage, BP 10, 2080 Ariana, Tunisie.
authors: Youssef
authors: Y
authors: Ammari
authors: Centre de Recherche en Oncologie Biologique et Oncopharmacologie (CRO2), INSERM UMR 911, Faculté de Pharmacie, Marseille, France; Aix-Marseille Université, France.
authors: José
authors: J
authors: Luis
authors: Centre de Recherche en Oncologie Biologique et Oncopharmacologie (CRO2), INSERM UMR 911, Faculté de Pharmacie, Marseille, France; Aix-Marseille Université, France.
authors: Hervé
authors: H
authors: Kovacic
mesh_terms: D000072283:A549 Cells; D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification / Q000494:pharmacology*; D018938:Caco-2 Cells; D002448:Cell Adhesion / Q000187:drug effects*; D018929:Cell Culture Techniques; D002465:Cell Movement / Q000187:drug effects*; D049109:Cell Proliferation / Q000187:drug effects*; D002470:Cell Survival / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D019073:HT29 Cells; D006801:Humans; D045787:Sesquiterpenes, Eudesmane / Q000302:isolation & purification / Q000494:pharmacology*; D013481:Superoxides / Q000378:metabolism*; D031367:Teucrium / Q000737:chemistry*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D045787:Sesquiterpenes, Eudesmane; D013481:Superoxides; C051082:beta-eudesmol
keywords: Adhesion; Migration; NADPH oxidase; Proliferation; Reactive oxygen species; β-eudesmol