title: Effects of apelin on reproductive functions: relationship with feeding behavior and energy metabolism.
abstract: Apelin is an adipose tissue derived peptidergic hormone. In this study, 40 male Sprague-Dawley rats were used (four groups; n = 10). Apelin-13 at three different dosages (1, 5 and 50 μg/kg) was given intraperitoneally while the control group received vehicle the same route for a period of 14 days. In results, apelin-13 caused significant decreases in serum testosterone, luteinizing hormone and follicle-stimulating hormone levels (p < 0.05). Administration of apelin-13 significantly increased body weights, food intake, serum low-density lipoprotein and total cholesterol levels (p < 0.05), but caused significant decreases in high-density lipoprotein levels (p < 0.05). Serum glucose and triglyceride levels were not significantly altered by apelin-13 administration. Significant decreases in both uncoupling protein (UCP)-1 levels in the white and brown adipose tissues and UCP-3 levels in the biceps muscle (p < 0.05) were noted. The findings of the study suggest that apelin-13 may not only lead to obesity by increasing body weight but also cause infertility by suppressing reproductive hormones.
authors: a Department of Physiology , Faculty of Medicine, Inonu University , Malatya , Turkey.
authors: Suat
authors: S
authors: Tekin
authors: b Department of Molecular Biology and Genetics , Faculty of Science, Bartin University , Bartin , Turkey.
authors: Yavuz
authors: Y
authors: Erden
authors: a Department of Physiology , Faculty of Medicine, Inonu University , Malatya , Turkey.
authors: Suleyman
authors: S
authors: Sandal
authors: c Department of Medical Biology , Faculty of Medicine, Firat University , Elazig , Turkey.
authors: Ebru
authors: E
authors: Etem Onalan
authors: d Department of Biochemistry , Faculty of Medicine, Inonu University , Malatya , Turkey.
authors: Fatma
authors: F
authors: Ozyalin
authors: e Department of Pathology , Faculty of Veterinary Medicine, Kafkas University , Kars , Turkey.
authors: Hasan
authors: H
authors: Ozen
authors: f Department of Physiology , Faculty of Medicine, Yeditepe University , Istanbul , Turkey.
authors: Bayram
authors: B
authors: Yilmaz
mesh_terms: D002001:Adipose Tissue, Brown / Q000187:drug effects / Q000378:metabolism; D052436:Adipose Tissue, White / Q000187:drug effects / Q000378:metabolism; D000818:Animals; D004305:Dose-Response Relationship, Drug; D002149:Energy Intake / Q000187:drug effects*; D004734:Energy Metabolism / Q000187:drug effects*; D005247:Feeding Behavior / Q000187:drug effects*; D006065:Gonadotropins, Pituitary / Q000037:antagonists & inhibitors / Q000097:blood; D006937:Hypercholesterolemia / Q000097:blood / Q000139:chemically induced* / Q000378:metabolism; D007248:Infertility, Male / Q000097:blood / Q000139:chemically induced* / Q000378:metabolism; D007274:Injections, Intraperitoneal; D036341:Intercellular Signaling Peptides and Proteins / Q000633:toxicity*; D008297:Male; D018482:Muscle, Skeletal / Q000187:drug effects / Q000378:metabolism; D050177:Overweight / Q000097:blood / Q000139:chemically induced* / Q000378:metabolism; D011897:Random Allocation; D017207:Rats, Sprague-Dawley; D013739:Testosterone / Q000037:antagonists & inhibitors / Q000097:blood; D036401:Toxicity Tests, Chronic; D000071256:Uncoupling Protein 1 / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism; D000071247:Uncoupling Protein 3 / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism; D015430:Weight Gain / Q000187:drug effects
chemical_list: D006065:Gonadotropins, Pituitary; D036341:Intercellular Signaling Peptides and Proteins; C000604373:Ucp1 protein, rat; C000604394:Ucp3 protein, rat; D000071256:Uncoupling Protein 1; D000071247:Uncoupling Protein 3; C495199:apelin-13 peptide; D013739:Testosterone
keywords: Apelin; body weight; food intake; reproductive functions; uncoupling proteins