title: Association of monocyte chemoattractant protein-1 gene 2518A/G polymorphism with diabetic retinopathy in type 2 diabetes mellitus: A meta-analysis.
abstract: OBJECTIVE
  The relationship between monocyte chemoattractant protein-1 (MCP-1) 2518 A/G polymorphism and diabetic retinopathy (DR) attracted intense interest recently, but the reported results are controversial. A meta-analysis was performed to assess the MCP-1 polymorphism associated with DR susceptibility in type 2 diabetes mellitus.
  
  
  METHODS
  Eligible studies were identified from PubMed, Embase, Web of science, Chinese Biomedical database, and references of retrieved articles. Pooled odds ratios (ORs) with their 95% confidence intervals (95%CI) were calculated by fixed or random-effects models.
  
  
  RESULTS
  Six studies involving 3415 patients without DR and 3468 with any DR were included in the final meta-analysis. Each 5 studies evaluated the associations of MCP-1 polymorphism and any DR and proliferative DR (PDR), respectively. Meta-analysis in fixed model demonstrated a significant association between MCP-1 polymorphism and any DR under the homozygous model (OR=1.36; 95%CI: 1.15-1.62, P<0.001), heterozygous model (OR=1.20; 95%CI: 1.02-1.42, P=0.031), dominant model (OR=1.28; 95%CI: 1.10-1.50, P=0.002), recessive model (OR=1.17; 95%CI: 1.05-1.31, P=0.004), and allelic model (OR=1.16; 95%CI: 1.07-1.25, P<0.001). Furthermore, a significant association of MCP-1 polymorphism and DR progression from non-proliferative DR to proliferative DR was identified under heterozygous model (OR=1.45; 95%CI: 1.04-2.02, P=0.030). Sensitivity analyses did not draw different findings.
  
  
  CONCLUSIONS
  Meta-analysis of existing data suggested that MCP-1 2518 A/G polymorphism affected the risk of presence and progression of DR in type 2 diabetes mellitus.
authors: Zhongshan Ophthalmic Center, State Key Laboratory of Ophthalmology, Sun Yat-sen University, Guangzhou, People's Republic of China.
authors: Wei
authors: W
authors: Wang
authors: Zhongshan Ophthalmic Center, State Key Laboratory of Ophthalmology, Sun Yat-sen University, Guangzhou, People's Republic of China.
authors: Miao
authors: M
authors: He
authors: Zhongshan Ophthalmic Center, State Key Laboratory of Ophthalmology, Sun Yat-sen University, Guangzhou, People's Republic of China. Electronic address: andyhwyz@aliyun.com.
authors: Wenyong
authors: W
authors: Huang
mesh_terms: D018932:Chemokine CCL2 / Q000235:genetics*; D003924:Diabetes Mellitus, Type 2 / Q000150:complications* / Q000235:genetics; D003930:Diabetic Retinopathy / Q000175:diagnosis / Q000209:etiology*; D020022:Genetic Predisposition to Disease; D006801:Humans; D011110:Polymorphism, Genetic / Q000235:genetics*; D012307:Risk Factors
chemical_list: C111835:CCL2 protein, human; D018932:Chemokine CCL2
keywords: Diabetic retinopathy; Gene polymorphisms; MCP-1; Meta-analysis; Monocyte chemoattractant protein