title: Giant Cell Arteritis which Developed after the Administration of Granulocyte-colony Stimulating Factor for Cyclic Neutropenia.
abstract: A 78-year-old woman diagnosed with cyclic neutropenia 5 years previously had been treated with recombinant granulocyte-colony stimulating factor (G-CSF). She developed fever, tenderness and distension of temporal arteries after the treatment with G-CSF. Magnetic resonance imaging and ultrasonography revealed wall thickening of the temporal arteries. She was therefore diagnosed with giant cell arteritis (GCA). Small vessel vasculitis has been reported as a complication of G-CSF. However, the development of large vessel vasculitis after G-CSF treatment is quite rare. To our knowledge, the present case is the first report of GCA suspected to be associated with coexisting cyclic neutropenia and G-CSF treatment.
authors: Unit of Translational Medicine, Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Japan.
authors: Masataka
authors: M
authors: Umeda
authors: Jin
authors: J
authors: Ikenaga
authors: Tomohiro
authors: T
authors: Koga
authors: Toru
authors: T
authors: Michitsuji
authors: Toshimasa
authors: T
authors: Shimizu
authors: Shoichi
authors: S
authors: Fukui
authors: Ayako
authors: A
authors: Nishino
authors: Yoshikazu
authors: Y
authors: Nakasima
authors: Sin-Ya
authors: SY
authors: Kawashiri
authors: Naoki
authors: N
authors: Iwamoto
authors: Kunihiro
authors: K
authors: Ichinose
authors: Yasuko
authors: Y
authors: Hirai
authors: Mami
authors: M
authors: Tamai
authors: Hideki
authors: H
authors: Nakamura
authors: Tomoki
authors: T
authors: Origuchi
authors: Atsushi
authors: A
authors: Kawakami
mesh_terms: D000368:Aged; D005260:Female; D013700:Giant Cell Arteritis / Q000139:chemically induced* / Q000000981:diagnostic imaging* / Q000473:pathology; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000008:administration & dosage / Q000009:adverse effects*; D006801:Humans; D008279:Magnetic Resonance Imaging; D009503:Neutropenia / Q000188:drug therapy*
chemical_list: D016178:Granulocyte-Macrophage Colony-Stimulating Factor