title: The Role of Stem Cells in the Treatment of Cerebral Palsy: a Review.
abstract: Cerebral palsy (CP) is a neuromuscular disease due to injury in the infant's brain. The CP disorder causes many neurologic dysfunctions in the patient. Various treatment methods have been used for the management of CP disorder. However, there has been no absolute cure for this condition. Furthermore, some of the procedures which are currently used for relief of symptoms in CP cause discomfort or side effects in the patient. Recently, stem cell therapy has attracted a huge interest as a new therapeutic method for treatment of CP. Several investigations in animal and human with CP have demonstrated positive potential of stem cell transplantation for the treatment of CP disorder. The ultimate goal of this therapeutic method is to harness the regenerative capacity of the stem cells causing a formation of new tissues to replace the damaged tissue. During the recent years, there have been many investigations on stem cell therapy. However, there are still many unclear issues regarding this method and high effort is needed to create a technology as a perfect treatment. This review will discuss the scientific background of stem cell therapy for cerebral palsy including evidences from current clinical trials.
authors: Department of Tissue Engineering and Applied Cell Sciences, School of Advanced Technologies in Medicine, Tehran University of medical sciences, 88, 10th floor, Italia Str., Keshavarz Blv, Tehran, Iran.
authors: Anahita
authors: A
authors: Kiasatdolatabadi
authors: Department of Tissue Engineering and Applied Cell Sciences, School of Advanced Technologies in Medicine, Tehran University of medical sciences, 88, 10th floor, Italia Str., Keshavarz Blv, Tehran, Iran.
authors: Nasrin
authors: N
authors: Lotfibakhshaiesh
authors: Department of Tissue Engineering and Applied Cell Sciences, School of Advanced Technologies in Medicine, Tehran University of medical sciences, 88, 10th floor, Italia Str., Keshavarz Blv, Tehran, Iran.|Wilmer Eye Institute, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
authors: Meysam
authors: M
authors: Yazdankhah
authors: Department of Tissue Engineering and Applied Cell Sciences, School of Advanced Technologies in Medicine, Tehran University of medical sciences, 88, 10th floor, Italia Str., Keshavarz Blv, Tehran, Iran.
authors: Somayeh
authors: S
authors: Ebrahimi-Barough
authors: Reproductive health research centre, Tehran University of medical sciences, Tehran, Iran.
authors: Mina
authors: M
authors: Jafarabadi
authors: School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
authors: Arman
authors: A
authors: Ai
authors: Department of Medical Biotechnology, School of Advanced Technologies in Medicine, International Campus, Tehran University of Medical Sciences, Tehran, Iran.
authors: Esmaeil
authors: E
authors: Sadroddiny
authors: Department of Tissue Engineering and Applied Cell Sciences, School of Advanced Technologies in Medicine, Tehran University of medical sciences, 88, 10th floor, Italia Str., Keshavarz Blv, Tehran, Iran. jafar_ai@tums.ac.ir.
authors: Jafar
authors: J
authors: Ai
mesh_terms: D000818:Animals; D001921:Brain / Q000187:drug effects / Q000503:physiopathology; D001930:Brain Injuries / Q000628:therapy*; D002454:Cell Differentiation / Q000502:physiology; D002547:Cerebral Palsy / Q000628:therapy*; D006801:Humans; D058953:Neural Stem Cells / Q000166:cytology*; D033581:Stem Cell Transplantation / Q000379:methods
keywords: Cerebral palsy; Clinical trials; Stem cell; Treatment