title: Detection of bowel inflammation with fused DWI/T2 images versus contrast-enhanced images in pediatric MR enterography with histopathologic correlation.
abstract: OBJECTIVE
  To evaluate the fused, colorized diffusion weighted imaging (DWI) and anatomic T2 images compared to routine contrast-enhanced T1 images at pediatric magnetic resonance enterography (MRE).
  
  
  METHODS
  Fused, colorized DWI/T2 images were created from patients with magnetic resonance enterography (MRE) and colonoscopy/biopsy. Radiologists noted inflammation in five bowel segments (terminal ileum-rectosigmoid colon) on postcontrast images and DWI/T2 images. Test characteristics and agreement were calculated.
  
  
  RESULTS
  For 20 patients, sensitivity/specificity/positive predictive value (PPV)/negative predictive value (NPV) were 0.53/0.90/0.77/0.76 for DWI/T2 and 0.45/0.90/0.72/0.73 for postcontrast images. Intraobserver agreement was ҡ=0.45-0.73. Interobserver agreement was ҡ=0.53 for DWI/T2 and ҡ=0.63 for postcontrast images.
  
  
  CONCLUSIONS
  DWI/T2 images are similar in sensitivity/specificity to contrast-enhanced images and with moderate intra/interobserver reliability.
authors: Department of Radiology and Biomedical Imaging, UCSF, 505 Parnassus Ave., San Francisco, CA 94143-0628. Electronic address: eric.ehman@ucsf.edu.
authors: Eric C
authors: EC
authors: Ehman
authors: Department of Radiology and Biomedical Imaging, UCSF Benioff Children's Hospital, 1975 4th Street, CL1578L, San Francisco, CA 94158. Electronic address: andrew.phelps@ucsf.edu.
authors: Andrew S
authors: AS
authors: Phelps
authors: Department of Radiology and Biomedical Imaging, UCSF, 505 Parnassus Ave., San Francisco, CA 94143-0628. Electronic address: michael.ohliger@ucsf.edu.
authors: Michael A
authors: MA
authors: Ohliger
authors: Department of Pediatrics, Division of Ped. Gastroenterology, UCSF Benioff Children's Hospital, Box 0136, 550 16th Street, San Francisco, CA 94134. Electronic address: sue.rhee@ucsf.edu.
authors: Sue J
authors: SJ
authors: Rhee
authors: Department of Radiology and Biomedical Imaging, UCSF Benioff Children's Hospital, 1975 4th Street, CL1578L, San Francisco, CA 94158. Electronic address: john.mackenzie@ucsf.edu.
authors: John D
authors: JD
authors: MacKenzie
authors: Department of Radiology and Biomedical Imaging, UCSF Benioff Children's Hospital, 1975 4th Street, CL1578L, San Francisco, CA 94158. Electronic address: jesse.courtier@ucsf.edu.
authors: Jesse L
authors: JL
authors: Courtier
mesh_terms: D000293:Adolescent; D002648:Child; D003092:Colitis / Q000175:diagnosis*; D003287:Contrast Media; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods; D005260:Female; D006801:Humans; D007079:Ileitis / Q000175:diagnosis*; D007089:Image Enhancement; D043183:Irritable Bowel Syndrome / Q000175:diagnosis; D008297:Male; D015588:Observer Variation; D011350:Proctocolitis / Q000175:diagnosis; D015203:Reproducibility of Results; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D055815:Young Adult
chemical_list: D003287:Contrast Media
keywords: Diffusion-weighted imaging; Enterography; MRI; Pediatric