title: The impact of drugs for multiple sclerosis on sleep.
abstract: Although there is a growing literature on the presence of sleep disorders in multiple sclerosis (MS), few studies have specifically addressed the impact of drugs on sleep of these patients. Moreover, even when sleep is considered, quantitative assessment by standardized questionnaires or polysomnography is lacking. The studies that have been done highlight that interferon-beta and some symptomatic medications may affect sleep, thus contributing to fatigue, depression, and poor quality of life; conversely, natalizumab and cannabinoids may improve sleep. Common limitations of the literature reviewed here are small sample size, selection bias, and often a lack of objective outcome measures. Clinicians need to remember to ask about sleep in all MS patients and intervene when appropriate. A systematic approach that takes sleep into account is recommended to enhance recognition and appropriate management of sleep disruption, including disorders related to medication. Consideration of the impact on sleep should also be part of the design of trials of new therapies.
authors: Sleep Research Center, Department of Neurology I.C., I.R.C.C.S. Oasi Maria SS., Troina, Italy.
authors: Giuseppe
authors: G
authors: Lanza
authors: Sleep Research Center, Department of Neurology I.C., I.R.C.C.S. Oasi Maria SS., Troina, Italy.
authors: Raffaele
authors: R
authors: Ferri
authors: Department of Medical and Surgical Sciences and Advanced Technologies, Section of Neurosciences, University of Catania, Catania, Italy.
authors: Rita
authors: R
authors: Bella
authors: Department of Clinical Neurosciences, Sleep Disorders Center, Università Vita-Salute San Raffaele, Milan, Italy.
authors: Luigi
authors: L
authors: Ferini-Strambi
mesh_terms: D003863:Depression / Q000139:chemically induced; D006801:Humans; D016899:Interferon-beta / Q000009:adverse effects*; D009103:Multiple Sclerosis / Q000150:complications / Q000188:drug therapy*; D011788:Quality of Life; D012890:Sleep / Q000187:drug effects*; D012893:Sleep Wake Disorders / Q000150:complications / Q000188:drug therapy*
chemical_list: D016899:Interferon-beta
keywords: Multiple sclerosis; disease-modifying drugs; neuroinflammation; quality of life; sleep disorders