title: Reduced saccadic inhibition of return to moving eyes in autism spectrum disorders.
abstract: Inhibition of Return (IOR) refers to slower reaction time to a target presented at the same location as a preceding stimulus. Here, we examine reflexive attention orienting via the saccadic IOR using a shift in gaze direction (i.e. from averted to direct) in faces presented as a peripheral cue, in upright and inverted orientations, in adults with Autism Spectrum Disorder (ASD) and typically developed comparison participants. While both groups showed an IOR in the inverted face condition, this effect was reduced in participants with ASD in the upright face condition, as compared to comparison participants, suggesting that moving eyes do not trigger reflexive exogenous orienting in individuals with ASD. Impaired reflexive orienting to eye gaze might severely compromise the later development of social functions in ASD, such as joint attention, face emotion recognition and mindreading.
authors: Ecole Normale Supérieure, PSL Research University, Département d'études cognitives, CNRS UMR 8129, Institut Jean Nicod, F-75005 Paris, France. Electronic address: tiziana.zalla@ens.fr.
authors: Tiziana
authors: T
authors: Zalla
authors: Ecole Normale Supérieure, PSL Research University, Département d'études cognitives, CNRS UMR 8129, Institut Jean Nicod, F-75005 Paris, France.
authors: Laura Gabriela
authors: LG
authors: Fernandez
authors: Ecole Normale Supérieure, PSL Research University, Département d'études cognitives, CNRS UMR 8129, Institut Jean Nicod, F-75005 Paris, France.
authors: Marie
authors: M
authors: Pieron
authors: e(ye)BRAIN, 1 bis rue Jean le Galleu, 94200 Ivry-sur-Seine, France.
authors: Magali
authors: M
authors: Seassau
authors: Department of Psychiatry, INSERM U 955, IMRB & University Paris Est Creteil, AP-HP, Henri Mondor-Albert Chenevier Hospitals, Creteil, France; Fondation FondaMental, French National Science Foundation, France.
authors: Marion
authors: M
authors: Leboyer
mesh_terms: D000328:Adult; D001288:Attention / Q000502:physiology*; D000067877:Autism Spectrum Disorder / Q000503:physiopathology*; D016022:Case-Control Studies; D006801:Humans; D007266:Inhibition, Psychological; D008297:Male; D008875:Middle Aged; D010775:Photic Stimulation / Q000379:methods; D011930:Reaction Time / Q000502:physiology; D012438:Saccades / Q000502:physiology*; D055815:Young Adult
keywords: Attention orienting; Autism; Face orientation; Gaze detection; Gaze shift