title: Human leucocyte antigen Class I and II alleles associated with anti-hepatitis C virus-positive patients of North India.
abstract: OBJECTIVE
  Humans are the only known natural hosts of hepatitis C virus (HCV). This study was undertaken to examine the frequencies of human leucocyte antigens (HLAs) Class I and Class II genotype profiles in anti-HCV-infected patients of Northern India.
  
  
  METHODS
  From a period of January 2013 to August 2014, 148 anti-HCV-positive patients of North India referred to the Department of Molecular Biology and Transplant Immunology, Indraprastha Apollo Hospitals, New Delhi, for performing HLA typing were included in the study.
  
  
  RESULTS
  AFNx0102, AFNx0131 allele frequency decreased significantly in anti-HCV-positive patients. Frequencies for HLA-B loci did not reach any statistical significance. Among the Class II alleles, HLA-DRB1FNx0103 and HLA-DRB1FNx0110 were significantly higher in the patient population, and HLA-DRB1FNx0115 was significantly decreased in the patient population as compared to the controls.
  
  
  CONCLUSIONS
  HLA-AFNx0133 was significantly increased as compared to control population and showed geographic variation in HCV-infected individuals of India.
authors: Department of Transplant Immunology, Molecular Biology and Transfusion Medicine, Apollo Hospitals, New Delhi, India.
authors: M
authors: M
authors: Chowdhry
authors: Department of Transplant Immunology, Molecular Biology and Transfusion Medicine, Apollo Hospitals, New Delhi, India.
authors: R N
authors: RN
authors: Makroo
authors: Department of Transplant Immunology, Molecular Biology and Transfusion Medicine, Apollo Hospitals, New Delhi, India.
authors: M
authors: M
authors: Singh
authors: Department of Transplant Immunology, Molecular Biology and Transfusion Medicine, Apollo Hospitals, New Delhi, India.
authors: S
authors: S
authors: Agrawal
authors: Department of Transplant Immunology, Molecular Biology and Transfusion Medicine, Apollo Hospitals, New Delhi, India.
authors: M
authors: M
authors: Kumar
authors: Department of Transplant Immunology, Molecular Biology and Transfusion Medicine, Apollo Hospitals, New Delhi, India.
authors: Y
authors: Y
authors: Thakur
mesh_terms: D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D060005:Genotyping Techniques; D016174:Hepacivirus / Q000276:immunology*; D006526:Hepatitis C / Q000235:genetics*; D018937:Hepatitis C Antibodies / Q000097:blood*; D015395:Histocompatibility Antigens Class I / Q000235:genetics*; D000949:Histocompatibility Antigens Class II / Q000235:genetics*; D006801:Humans; D007194:India
chemical_list: D018937:Hepatitis C Antibodies; D015395:Histocompatibility Antigens Class I; D000949:Histocompatibility Antigens Class II