title: Effects of peptides from Phascolosoma esculenta on spatial learning and memory via anti-oxidative character in mice.
abstract: This study was aimed to evaluate effects of peptides from Phascolosoma esculenta and its ferrous-chelating peptides on spatial learning and memory in mice by Morris water maze test. 100mg/kg peptide on spatial learning and memory function about quadrant time and passing times through the platform better than 50 and 150mg/kg group during exploration period (P<0.05), without body weight between the weight and visual ability. 100mg/kg ferrous-chelating peptide group performed better ability of spatial learning and memory than 100mg/kg peptide group (P<0.05). qRT-PCR results showed that 50 and 100mg/kg administration peptide and 100mg/kg ferrous-chelating peptide can significantly improve mRNA expression of NR2A, NR2B and BDNF with oxidative stress status (GSH-Px, SOD, TAC and MDA), which explained mechanism for improving learning and memory ability in mice via anti-oxidative character.
authors: School of Marine Sciences, Key Laboratory of Animal Protein Food Deep Processing Technology of Zhejiang Province, Ningbo University, Ningbo 315211, Zhejiang Province, PR China. Electronic address: hahaliang408@126.com.
authors: Lianliang
authors: L
authors: Liu
authors: School of Marine Sciences, Key Laboratory of Animal Protein Food Deep Processing Technology of Zhejiang Province, Ningbo University, Ningbo 315211, Zhejiang Province, PR China.
authors: Jinxuan
authors: J
authors: Cao
authors: School of Marine Sciences, Key Laboratory of Animal Protein Food Deep Processing Technology of Zhejiang Province, Ningbo University, Ningbo 315211, Zhejiang Province, PR China.
authors: Jiong
authors: J
authors: Chen
authors: School of Marine Sciences, Key Laboratory of Animal Protein Food Deep Processing Technology of Zhejiang Province, Ningbo University, Ningbo 315211, Zhejiang Province, PR China.
authors: Xin
authors: X
authors: Zhang
authors: School of Marine Sciences, Key Laboratory of Animal Protein Food Deep Processing Technology of Zhejiang Province, Ningbo University, Ningbo 315211, Zhejiang Province, PR China.
authors: Zufang
authors: Z
authors: Wu
authors: School of Marine Sciences, Key Laboratory of Animal Protein Food Deep Processing Technology of Zhejiang Province, Ningbo University, Ningbo 315211, Zhejiang Province, PR China.
authors: Huan
authors: H
authors: Xiang
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage*; D001835:Body Weight / Q000187:drug effects; D019208:Brain-Derived Neurotrophic Factor / Q000378:metabolism; D017362:Cyclic AMP Response Element-Binding Protein / Q000378:metabolism; D005106:Exploratory Behavior / Q000187:drug effects; D006624:Hippocampus / Q000187:drug effects / Q000378:metabolism; D007502:Iron Chelating Agents / Q000008:administration & dosage*; D018782:Maze Learning / Q000187:drug effects; D051379:Mice; D008813:Mice, Inbred ICR; D018384:Oxidative Stress; D010455:Peptides / Q000008:administration & dosage* / Q000302:isolation & purification; D011077:Polychaeta / Q000737:chemistry; D012333:RNA, Messenger / Q000378:metabolism; D016194:Receptors, N-Methyl-D-Aspartate / Q000378:metabolism; D065853:Spatial Learning / Q000187:drug effects*; D065852:Spatial Memory / Q000187:drug effects*; D013550:Swimming
chemical_list: D000975:Antioxidants; D019208:Brain-Derived Neurotrophic Factor; C492004:Creb1 protein, mouse; D017362:Cyclic AMP Response Element-Binding Protein; D007502:Iron Chelating Agents; C120997:NR2A NMDA receptor; C121001:NR2B NMDA receptor; D010455:Peptides; D012333:RNA, Messenger; D016194:Receptors, N-Methyl-D-Aspartate
keywords: Ferrous-chelating peptide; Learning and memory; Morris water maze; Peptide; Phascolosoma esculenta