title: In vivo cytological observation of liver and spleen by using high-resolution microendoscopy system under endoscopic ultrasound guidance: A preliminary study using a swine model.
abstract: Endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) is useful to obtain specimens from lesions underlying deep parts of the liver and spleen. However, the development of novel ancillary techniques must be explored to reduce the number of needle passes and potential adverse effects during this procedure. We conducted an animal study using a swine to demonstrate technical feasibility of in vivo cytological observation of liver and spleen using the high-resolution microendoscopy (HRME) system under EUS guidance. We successfully performed the study. No significant acute adverse events occurred during the procedure. The HRME system could obtain clear images representing cytology-level morphology of spleen and liver. Hence, it is found out that in vivo cytological observation of liver and spleen using the HRME system under EUS guidance is technically feasible.
authors: Department of Gastroenterology, Hepatology and Nutrition, MD Anderson Cancer Center, Houston, Texas, USA.
authors: Rei
authors: R
authors: Suzuki
authors: Department of Neurosurgery, The University of Texas Health Science Center at Houston Medical School; Department of Bioengineering, Rice University, Houston, Texas, USA.
authors: Dongsuk
authors: D
authors: Shin
authors: Department of Bioengineering, Rice University, Houston, Texas, USA.
authors: Rebecca
authors: R
authors: Richards-Kortum
authors: Department of Epigenetics and Molecular Carcinogenesis, MD Anderson Cancer Center, University of Texas, Science Park, Smithville, Texas, USA.
authors: Lezlee
authors: L
authors: Coghlan
authors: Department of Gastroenterology, Hepatology and Nutrition, MD Anderson Cancer Center, Houston, Texas, USA.
authors: Manoop S
authors: MS
authors: Bhutani