title: Fourfold increase in prevalence of gestational diabetes mellitus after adoption of the new International Association of Diabetes and Pregnancy Study Groups (IADPSG) criteria.
abstract: BACKGROUND
  The aim was to evaluate the influence of the new International Association of Diabetes and Pregnancy Study Groups (IADPSG) guidelines for screening of gestational diabetes mellitus (GDM) on GDM prevalence in a cohort from a Swiss tertiary hospital.
  
  
  METHODS
  This was a retrospective cohort study involving all pregnant women who were screened for GDM between 24 and 28 weeks of gestation. From 2008 until 2010 (period 1), a two-step approach with 1-h 50 g glucose challenge test (GCT) was used, followed by fasting, 1- and 2-h glucose measurements after a 75 g oral glucose tolerance test (OGTT) in case of a positive GCT. From 2010 until 2013 (period 2), all pregnant women were tested with a one-step 75 g OGTT according to new IADPSG guidelines. In both periods, women with risk factors could be screened directly with a 75 g OGTT in early pregnancy.
  
  
  RESULTS
  Overall, 647 women were eligible for the study in period 1 and 720 in period 2. The introduction of the IADPSG criteria resulted in an absolute increase of GDM prevalence of 8.5% (3.3% in period 1 to 11.8% in period 2).
  
  
  CONCLUSIONS
  The adoption of the IADPSG criteria resulted in a considerable increase in GDM diagnosis in our Swiss cohort. Further studies are needed to investigate if the screening is cost effective and if treatment of our additionally diagnosed GDM mothers might improve short-term as well as long-term outcome.
authors: Department of Obstetrics and Gynaecology, University Hospital Basel, Spitalstrasse 21, 4031 Basel.
authors: Evelyn A
authors: http://orcid.org/0000-0001-5382-1353
authors: EA
authors: Huhn
authors: Department of Surgery, Hospital Dornach, Dornach.
authors: Nadine
authors: N
authors: Massaro
authors: Department of Anaesthesiology, Cantonal Hospital Baselland, Liestal.
authors: Simone
authors: S
authors: Streckeisen
authors: Department of Obstetrics and Gynaecology, University Hospital Basel, Basel.
authors: Gwendolin
authors: G
authors: Manegold-Brauer
authors: Department of Obstetrics and Gynaecology, University Hospital Basel, Basel.
authors: Andreas
authors: A
authors: Schoetzau
authors: Department of Neonatology, University of Basel Children's Hospital, Basel.
authors: Sven M
authors: SM
authors: Schulzke
authors: Department of Endocrinology and Diabetes, University Hospital Basel, Basel.
authors: Bettina
authors: B
authors: Winzeler
authors: Department of Obstetrics and Gynaecology, University Hospital Basel, Basel.
authors: Irene
authors: I
authors: Hoesli
authors: Department of Obstetrics and Gynaecology, University Hospital Basel, Basel.
authors: Olav
authors: O
authors: Lapaire
mesh_terms: D000328:Adult; D015992:Body Mass Index; D015331:Cohort Studies; D016640:Diabetes, Gestational / Q000175:diagnosis / Q000453:epidemiology* / Q000473:pathology; D005260:Female; D005320:Fetal Macrosomia / Q000175:diagnosis; D005951:Glucose Tolerance Test / Q000379:methods; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D008403:Mass Screening; D017410:Practice Guidelines as Topic; D011247:Pregnancy; D011256:Pregnancy Outcome; D015995:Prevalence; D012189:Retrospective Studies; D012307:Risk Factors; D013557:Switzerland / Q000453:epidemiology
keywords: Gestational diabetes mellitus; IADPSG criteria; oral glucose tolerance test; pregnancy; prevalence; screening