title: Iridoids and phenylethanoid glycosides from the aerial parts of Ajuga tenorei, an endemic Italian species.
abstract: We report the first analysis in absolute, and in particular, concerning the phytochemical pattern, about an endemic Italian species, Ajuga tenorei C. Presl. The analysis, performed by means of techniques such as Column Chromatography and NMR spectroscopy and Mass spectrometry, led to the isolation and the identification of five compounds namely verbascoside (1), echinacoside (2), ajugoside (3), harpagide (4) and 8-O-acetylharpagide (5). The presence of these compounds is important from both chemotaxonomic and ethno-pharmacological point of view. For what concerns the first point is confirmed the correct botanical classification of the species. The isolated compounds are also known to exert peculiar pharmacological activities and their presence may give a rationale to the historical medicinal properties associated to the Ajuga genus in general, since these plants have a long traditional use in many parts of the world. Such fact might suggest the use of also this species in this sense.
authors: b Dipartimento di Biologia Ambientale , Università di Roma 'La Sapienza' , Roma , Italy.
authors: Claudio
authors: C
authors: Frezza
authors: a Dipartimento di Chimica , Università di Roma 'La Sapienza' , Roma , Italy.
authors: Alessandro
authors: A
authors: Venditti
authors: c Ente Parco Nazionale della Majella , Guardiagrele , Italy.
authors: Mirella
authors: M
authors: Di Cecco
authors: c Ente Parco Nazionale della Majella , Guardiagrele , Italy.
authors: Giampiero
authors: G
authors: Ciaschetti
authors: b Dipartimento di Biologia Ambientale , Università di Roma 'La Sapienza' , Roma , Italy.
authors: Mauro
authors: M
authors: Serafini
authors: a Dipartimento di Chimica , Università di Roma 'La Sapienza' , Roma , Italy.
authors: Armandodoriano
authors: A
authors: Bianco
mesh_terms: D031328:Ajuga / Q000737:chemistry*; D005960:Glucosides / Q000302:isolation & purification; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification*; D057889:Iridoid Glycosides / Q000302:isolation & purification; D039823:Iridoids / Q000737:chemistry / Q000302:isolation & purification*; D007558:Italy; D013058:Mass Spectrometry; D010636:Phenols / Q000302:isolation & purification; D035261:Plant Components, Aerial / Q000737:chemistry; D010936:Plant Extracts / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry; D011714:Pyrans / Q000302:isolation & purification; D059808:Polyphenols
chemical_list: D005960:Glucosides; D006027:Glycosides; D057889:Iridoid Glycosides; D039823:Iridoids; D010636:Phenols; D010936:Plant Extracts; D011714:Pyrans; C058956:acteoside; D059808:Polyphenols; C477173:ajugoside; C077626:8-O-acetylharpagide; C060297:echinacoside; C033250:harpagide
keywords: Ajuga tenorei C. Presl; chemotaxonomy; ethno-pharmacology; iridoids; phenyl-ethanoid glycosides