title: Association Between HLA Type and Skin Cancer in Kidney Transplant Recipients.
abstract: BACKGROUND
  Organ transplant recipients (OTRs) are more susceptible to various diseases, among them cancers. Nonmelanoma skin cancers (NMSC) represent the most common malignancies in OTRs in Europe. Due to the significantly higher morbidity, aggressive and rapid progression, and poor prognosis of NMSC in the OTR population, these patients require a special oncological approach. Intensive attention should therefore be paid to factors predisposing OTRs to the development of cancer. The aim of this study was to establish the role of genetic factors in the pathogenesis of skin cancer in kidney transplant recipients (KTRs).
  
  
  METHODS
  This single-center study was performed in 39 KTRs with posttransplant NMSC. The frequency of particular types of HLA Class I (HLA-A and HLA-B) and Class II (HLA-DR) in each group were compared to establish the association between the HLA type and risk of skin cancer after renal transplantation.
  
  
  RESULTS
  HLA-DR15 were more commonly detected in patients with MNSC than in the control group of KTRs (P = .014) There was also a positive correlation between HLA-B18 and skin squamous cell carcinoma. The antigen was more often recorded in KTRs with squamous cell carcinoma than in KTRs without NMSC (P = .03) and in the general population (P = .002).
  
  
  CONCLUSIONS
  Patients who are positive for HLA-BR15 and HLA-B18 should be under special dermatologic surveillance due to the potentially high risk of skin cancer.
authors: Department of Nephrology, Transplantology and Internal Diseases, Medical University of Gdansk, Gdansk, Poland. Electronic address: cega@gumed.edu.pl.
authors: A
authors: A
authors: Cegielska
authors: Department of Nephrology, Transplantology and Internal Diseases, Medical University of Gdansk, Gdansk, Poland.
authors: A
authors: A
authors: Dębska-Ślizień
authors: Department of Clinical Immunology and Transplantology, Medical University of Gdansk, Gdansk, Poland.
authors: G
authors: G
authors: Moszkowska
authors: Copernicus-Independent Public Healthcare Centre-Dermatology & Venereology Clinic, Gdansk, Poland.
authors: B
authors: B
authors: Imko-Walczuk
authors: Department of Nephrology, Transplantology and Internal Diseases, Medical University of Gdansk, Gdansk, Poland.
authors: B
authors: B
authors: Rutkowski
mesh_terms: D000328:Adult; D005060:Europe; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D015395:Histocompatibility Antigens Class I / Q000235:genetics*; D000949:Histocompatibility Antigens Class II / Q000235:genetics*; D006801:Humans; D016030:Kidney Transplantation / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D012878:Skin Neoplasms / Q000209:etiology / Q000235:genetics*; D066027:Transplant Recipients
chemical_list: D015395:Histocompatibility Antigens Class I; D000949:Histocompatibility Antigens Class II