title: Efficacy and Usefulness of New Single-Needle Intensive Granulocyte and Monocyte Adsorptive Apheresis in Active Ulcerative Colitis Patients Without Corticosteroids and Biologics.
abstract: Intensive granulocyte and monocyte adsorptive apheresis (GMA) twice weekly is effective and safe for patients with active ulcerative colitis (UC), but the requirement for maintaining two blood access routes is problematic. Here we compared the efficacy and safety of one-route blood access intensive GMA using a single-needle (SN) and conventional two-route blood access intensive GMA using a double-needle (DN) in patients with active UC not undergoing corticosteroid therapy. Among 80 active UC patients, 38 patients received SN intensive GMA and 42 patients received DN intensive GMA. The clinical remission ratio and mucosal healing ratio at 6 weeks, and the cumulative non-relapse ratio at 52 weeks did not differ significantly between groups. In addition, no serious or mild adverse effects were observed in SN intensive GMA. SN intensive GMA may be an adequate and novel therapeutic option for active UC as an alternative therapy before using corticosteroids.
authors: Department of Nephrology, Osaka Saiseikai Nakatsu Hospital, Osaka, Japan.
authors: Keiji
authors: K
authors: Shimazu
authors: Department of Gastroenterology and Hepatology, Osaka Saiseikai Nakatsu Hospital, Osaka, Japan.
authors: Takumi
authors: T
authors: Fukuchi
authors: Clinical Engineering, Osaka Saiseikai Nakatsu Hospital, Osaka, Japan.
authors: Insung
authors: I
authors: Kim
authors: Clinical Engineering, Osaka Saiseikai Nakatsu Hospital, Osaka, Japan.
authors: Yuki
authors: Y
authors: Noguchi
authors: Department of Nephrology, Osaka Saiseikai Nakatsu Hospital, Osaka, Japan.
authors: Megumi
authors: M
authors: Iwata
authors: Department of Gastroenterology and Hepatology, Osaka Saiseikai Nakatsu Hospital, Osaka, Japan.|Department of Gastroenterology and Hepatology, Kobe Hokuto Hospital, Kobe, Japan.
authors: Shintaro
authors: S
authors: Koyama
authors: Department of Gastroenterology and Hepatology, Osaka Saiseikai Nakatsu Hospital, Osaka, Japan.
authors: Satoshi
authors: S
authors: Ubukata
authors: Department of Nephrology, Osaka Saiseikai Nakatsu Hospital, Osaka, Japan.
authors: Atsuo
authors: A
authors: Tanaka
mesh_terms: D000305:Adrenal Cortex Hormones; D000328:Adult; D001688:Biological Products; D001781:Blood Component Removal / Q000295:instrumentation* / Q000379:methods*; D003093:Colitis, Ulcerative / Q000628:therapy*; D005260:Female; D006098:Granulocytes; D006801:Humans; D008297:Male; D009000:Monocytes; D012074:Remission Induction; D016896:Treatment Outcome
chemical_list: D000305:Adrenal Cortex Hormones; D001688:Biological Products
keywords: Intensive granulocyte and monocyte adsorptive apheresis; Single-needle induction; Ulcerative colitis