title: Skeletal muscle fiber-type specific succinate dehydrogenase activity in cerebral palsy.
abstract: Children with cerebral palsy (CP) exhibit increased energy expenditure during movement, but whether this is due in part to decrements in skeletal muscle mitochondrial oxidative capacity is unknown. Accordingly, we compared fiber-type specific succinate dehydrogenase (SDH) activity in children with CP with typically developing (TD) children.
  
  
  
  SDH activity and myofiber areas of type 1 and 2A fibers were measured in semitendinosus biopsies of both groups (n = 5/group).
  
  
  
  SDH activity was ∼35% higher in type 1 compared with type 2A fibers, but there were no differences between groups. Average myofiber area was 45% smaller in CP versus TD (P < 0.05), and type 2A fibers were 32% larger than type 1 fibers (P < 0.05) only in TD children.
  
  
  
  Fiber-type specific SDH activity is similar between TD children and children with CP. This suggests that increased energy expenditure in children with CP is not related to impaired mitochondrial oxidative capacity. Muscle Nerve, 2016 Muscle Nerve 55: 122-124, 2017.
authors: School of Medicine, University of California, San Diego, California, USA.
authors: Andrew M
authors: AM
authors: Zogby
authors: Department of Orthopaedic Surgery, University of California, San Diego, California, USA.|Department of Veterans Affairs Medical Center, San Diego, California, USA.
authors: Sudarshan
authors: S
authors: Dayanidhi
authors: Department of Orthopaedic Surgery, University of California, San Diego, California, USA.|Department of Orthopaedics, Rady Children's Hospital, San Diego, California, USA.
authors: Henry G
authors: HG
authors: Chambers
authors: Department of Orthopaedic Surgery, University of California, San Diego, California, USA.|Biomedical Sciences Program, University of California, San Diego, California, USA.
authors: Simon
authors: S
authors: Schenk
authors: Department of Orthopaedic Surgery, University of California, San Diego, California, USA.|Department of Veterans Affairs Medical Center, San Diego, California, USA.|Department of Bioengineering, University of California, San Diego, California, USA.
authors: Richard L
authors: RL
authors: Lieber
mesh_terms: D000293:Adolescent; D002547:Cerebral Palsy / Q000473:pathology*; D002648:Child; D005260:Female; D006801:Humans; D007797:Laminin / Q000378:metabolism; D008297:Male; D018485:Muscle Fibers, Skeletal / Q000201:enzymology*; D013385:Succinate Dehydrogenase / Q000378:metabolism*; D055815:Young Adult
chemical_list: D007797:Laminin; D013385:Succinate Dehydrogenase
keywords: cerebral palsy; energy expenditure; fiber type; oxidative capacity; skeletal muscle; succinate dehydrogenase