title: Mismatch repair system proteins in oral benign and malignant lesions.
abstract: Different environmental agents may cause DNA mutations by disrupting its double-strand structure; however, even normal DNA polymerase function may synthesize mismatch nucleotide bases, occasionally demonstrating failure in its proofreading activity. To overcome this issue, mismatch repair (MMR) system, a group of proteins specialized in finding mispairing bases and small loops of insertion or deletion, works to avoid the occurrence of mutations that could ultimately lead to innumerous human diseases. In the last decades, the role of MMR proteins in oral carcinogenesis and in the development of other oral cavity neoplasms has grown, but their importance in the pathogenesis and their prognostic potential for patients affected by oral malignancies, especially oral squamous cell carcinoma (OSCC), remain unclear. Therefore, in this manuscript we aimed to review and critically discuss the currently available data on MMR proteins expression in oral potentially malignant lesions, in OSCC, and in other oral neoplasms to better understand their relevance in these lesions.
authors: Department of Oral Diagnosis, Piracicaba Dental School, University of Campinas, Piracicaba, Brazil.
authors: Gleyson Kleber do
authors: GK
authors: Amaral-Silva
authors: Department of Pathology, School of Dentistry, Federal University of Rio Grande do Sul, Porto Alegre, Brazil.
authors: Manoela Domingues
authors: MD
authors: Martins
authors: Service of Buccal Pathology, João de Barros Barreto University Hospital, Federal University of Pará, Belém, Brazil.
authors: Hélder Antônio Rebelo
authors: HA
authors: Pontes
authors: Department of Oral Medicine, Sírio-Libanês Hospital, São Paulo, Brazil.
authors: Eduardo Rodrigues
authors: ER
authors: Fregnani
authors: Department of Oral Diagnosis, Piracicaba Dental School, University of Campinas, Piracicaba, Brazil.
authors: Márcio Ajudarte
authors: MA
authors: Lopes
authors: Department of Oral Diagnosis, Piracicaba Dental School, University of Campinas, Piracicaba, Brazil.
authors: Felipe Paiva
authors: FP
authors: Fonseca
authors: Department of Oral Diagnosis, Piracicaba Dental School, University of Campinas, Piracicaba, Brazil.
authors: Pablo Agustin
authors: PA
authors: Vargas
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000378:metabolism; D053843:DNA Mismatch Repair; D006801:Humans; D008048:Lip Neoplasms / Q000378:metabolism; D009062:Mouth Neoplasms / Q000378:metabolism*; D000074080:MutS Proteins / Q000378:metabolism*
chemical_list: D000074080:MutS Proteins
keywords: MLH; MSH; MutL; MutS; leukoplakia; mismatch repair system; oral cancer