title: [Lipoid Pneumonia Associated with Lipid-Containing Nasal Sprays and Nose Drops].
abstract: BACKGROUND
  Regularly updating the German pharmacopoeia on contemporary preparations DAC/NRF, chapter "Nasal Applications" and the recommendations on "Nasal Oils" as well as "Nasal Ointments and Emulsions", the issue of the risk of lipoid pneumonia associated with the use of plant oils and when compared to mineral oils arose.
  
  
  METHODS
  We searched different databases: the "Grosse Deutsche Arzneimittelspezialitäten-Taxe" containing all products available in German pharmacies, the Cochrane Library, the pharmacovigilance-database of the BfArM, and Medline to evaluate the benefit/risk-ratio of plant oils in nasal drops and sprays.
  
  
  RESULTS
  In German pharmacies, a number of both, mineral oil-containing drugs for nasal application and plant oil-containing medical devices are available. The risk of lipoid pneumonia described for mineral oil-containing nasal products can not entirely be transferred to plant oil-containing products. However, evidence from the literature suggests a risk for lipoid pneumonia, which needs to be considered given the non-proven efficacy of such medical devices in the majority of proposed indications. To minimize risks, recommendations are made for patient groups that should not use lipid-containing nasal products.
  
  
  CONCLUSIONS
  Acknowledging the potential lethal outcome of lipoid pneumonia, a demanding diagnosis, and absence of a specific therapy, lipid-containing nasal products should be used only with great caution. Based on the current knowledge, the statements regarding the risk of lipoid pneumonia for lipid-containing nasal products in the DAC/NRF should not be modified.
authors: Arzneimittelkommission der Deutschen Apotheker (AMK), Berlin.
authors: M
authors: M
authors: Ganso
authors: Arzneimittelkommission der Deutschen Apotheker (AMK), Berlin.
authors: R
authors: R
authors: Goebel
authors: Govi-Verlag Pharmazeutischer Verlag GmbH, NRF, Eschborn.
authors: S
authors: S
authors: Melhorn
authors: Lebensmittelchemie und Toxikologie, Technische Universitat Kaiserslautern, Kaiserslautern.
authors: D
authors: D
authors: Schrenk
authors: Arzneimittelkommission der Deutschen Apotheker (AMK), Berlin.
authors: M
authors: M
authors: Schulz
mesh_terms: D006801:Humans; D008055:Lipids / Q000009:adverse effects*; D008899:Mineral Oil; D059085:Nasal Sprays; D009666:Nose; D011017:Pneumonia, Lipid / Q000209:etiology*
chemical_list: D008055:Lipids; D059085:Nasal Sprays; D008899:Mineral Oil