title: Biocompatible Red Fluorescent Organic Nanoparticles with Tunable Size and Aggregation-Induced Emission for Evaluation of Blood-Brain Barrier Damage.
abstract: Detection of damage to the blood-brain barrier (BBB) is important for the diagnosis of brain diseases and therapeutic drug evaluation. The widely used probe, Evans blue, suffers from low specificity and high toxicity in vivo. It is shown that organic nanoparticles with tuneable size, good biocompatibility, and aggregation-induced emission characteristics offer high detection specificity to detect BBB damage via a photothrombotic ischemia rat model.
authors: Department of Chemical and Biomolecular Engineering, National University of Singapore, 4 Engineering Drive 4, Singapore, 117585.|NUS Graduate School for Integrative Sciences and Engineering, National University of Singapore, 28 Medical Drive, #05-01, Singapore, 117456.
authors: Xiaolei
authors: X
authors: Cai
authors: Singapore Institute for Neurotechnology (SINAPSE), National University of Singapore, 28 Medical Drive, Singapore, 117456.|Department of Biomedical Engineering, National University of Singapore, 21 Lower Kent Ridge Road, Singapore, 119077.
authors: Aishwarya
authors: A
authors: Bandla
authors: Department of Chemical and Biomolecular Engineering, National University of Singapore, 4 Engineering Drive 4, Singapore, 117585.
authors: Duo
authors: D
authors: Mao
authors: Department of Chemical and Biomolecular Engineering, National University of Singapore, 4 Engineering Drive 4, Singapore, 117585.
authors: Guangxue
authors: G
authors: Feng
authors: Department of Chemistry and Division of Biomedical Engineering, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, 999077.
authors: Wei
authors: W
authors: Qin
authors: Singapore Institute for Neurotechnology (SINAPSE), National University of Singapore, 28 Medical Drive, Singapore, 117456. ldliao@nhri.org.tw.|Institute of Biomedical Engineering and Nanomedicine, National Health Research Institutes, 35 Keyan Road, Zhunan Town, Miaoli County, 35053, Taiwan. ldliao@nhri.org.tw.
authors: Lun-De
authors: LD
authors: Liao
authors: Singapore Institute for Neurotechnology (SINAPSE), National University of Singapore, 28 Medical Drive, Singapore, 117456.|Department of Biomedical Engineering, National University of Singapore, 21 Lower Kent Ridge Road, Singapore, 119077.
authors: Nitish
authors: N
authors: Thakor
authors: Department of Chemistry and Division of Biomedical Engineering, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, 999077.
authors: Ben Zhong
authors: BZ
authors: Tang
authors: Department of Chemical and Biomolecular Engineering, National University of Singapore, 4 Engineering Drive 4, Singapore, 117585. cheliub@nus.edu.sg.|Institute of Materials Research and Engineering, 2 Fusionopolis Way, Innovis, #08-03, Singapore, 138634. cheliub@nus.edu.sg.
authors: Bin
authors: B
authors: Liu
mesh_terms: D000818:Animals; D001672:Biocompatible Materials; D001692:Biological Transport; D001812:Blood-Brain Barrier; D002545:Brain Ischemia; D004396:Coloring Agents; D053758:Nanoparticles; D051381:Rats
chemical_list: D001672:Biocompatible Materials; D004396:Coloring Agents
keywords: aggregation-induced emission; blood-brain barrier damage; nanoparticles; photothrombotic ischemia; stroke