title: [A case of 63,X/64,XX mosaicism in a subfertile pony mare].
abstract: The present case report describes a 6-year old subfertile pony mare, which became pregnant after the eleventh artificial insemination. The examination of the ovaries and the uterus did not reveal any abnormal clinical findings and the mare showed a regular oestrous cycle. Based on cytogenetic and molecular genetic analyses it became possible to elucidate the observed subfertility. The mosaic karyotype of the mare consisted of 63,X (20%) and 64,XX (80%) cells. A PCR analysis failed to amplify sequences from the equine SRY gene. The observed classic 63,X/64,XX mosaicism is a plausible explanation for the subfertility of the mare.
authors: Institut für Genetik, Vetsuisse-Fakultät Bern, Universität Bern.
authors: A
authors: A
authors: Pieńkowska-Schelling
authors: Pferdezentrum Bad Saarow, Klinik für Pferde, Freie Universität Berlin.
authors: J
authors: J
authors: Handler
authors: Pferdezentrum Bad Saarow, Klinik für Pferde, Freie Universität Berlin.
authors: S
authors: S
authors: Neuhauser
authors: Klinik für Reproduktionsmedizin und Zentrum für klinische Studien, Vetsuisse-Fakultät Zürich, Universität Zürich.
authors: C
authors: C
authors: Schelling
mesh_terms: D000818:Animals; D005260:Female; D024282:Genes, sry / Q000235:genetics; D006736:Horses / Q000235:genetics*; D007247:Infertility, Female / Q000235:genetics / Q000662:veterinary*; D007315:Insemination, Artificial / Q000662:veterinary; D059785:Karyotype; D009030:Mosaicism / Q000662:veterinary*; D016133:Polymerase Chain Reaction / Q000662:veterinary; D011247:Pregnancy; D014960:X Chromosome / Q000235:genetics*
keywords: 63,X/64,XX; Pferd; SRY negativ; SRY negative; chromosomal mosaic; chromosomales Mosaik; horse; reduzierte Fruchtbarkeit; subfertility