title: Well-Differentiated Laryngeal/Hypopharyngeal Liposarcoma in the MDM2 Era Report of Three Cases and Literature Review.
abstract: Laryngeal/hypopharyngeal liposarcomas are very rare, fewer than 40 cases have been reported. These tumors are polypoid, with a male predisposition, and usually cause hoarseness and difficulty breathing. Their clinical course is characterized by multiple local recurrences. No distant metastasis has been reported, and dedifferentiation is extremely rare. In sum, the prognosis of these tumors is excellent; the 5-year survival rate is essentially 100 %. Pathologic diagnosis of these well-differentiated liposarcomas can be challenging. Many of them were initially diagnosed as benign lipoma, fibrovascular polyp, or "inflammatory polyp". The correct diagnosis is usually made after multiple recurrences. On the other hand, the literature bears out that these incorrect diagnoses do not impact disease-specific survival. Here, we report three patients with laryngeal/hypopharyngeal well-differentiated liposarcomas; this is the first documentation of MDM2 amplification in liposarcomas at this site.
authors: Department of Pathology and Anatomic Sciences, SUNY at Buffalo, Buffalo, NY, 14214, USA.
authors: Hui
authors: H
authors: Zhu
authors: Department of Pathology and Anatomic Sciences, SUNY at Buffalo, Buffalo, NY, 14214, USA.
authors: Jihong
authors: J
authors: Sun
authors: Department of Pathology, University of Alabama at Birmingham, Birmingham, 35249, AL, USA.
authors: Shi
authors: S
authors: Wei
authors: Department of Pathology and Anatomic Sciences, SUNY at Buffalo, Buffalo, NY, 14214, USA.
authors: Diping
authors: D
authors: Wang
authors: Department of Pathology and Anatomic Sciences, SUNY at Buffalo, Buffalo, NY, 14214, USA. mgensler@buffalo.edu.
authors: Margaret
authors: M
authors: Brandwein
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D005784:Gene Amplification; D006801:Humans; D007012:Hypopharyngeal Neoplasms / Q000235:genetics* / Q000473:pathology; D007822:Laryngeal Neoplasms / Q000235:genetics* / Q000473:pathology; D008080:Liposarcoma / Q000235:genetics* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D051736:Proto-Oncogene Proteins c-mdm2 / Q000235:genetics*
chemical_list: C497206:MDM2 protein, human; D051736:Proto-Oncogene Proteins c-mdm2
keywords: Head and neck; Larynx; Liposarcoma; Pharynx