title: Transition-Metal-Free Stereospecific Cross-Coupling with Alkenylboronic Acids as Nucleophiles.
abstract: We herein report a transition-metal-free cross-coupling between secondary alkyl halides/mesylates and aryl/alkenylboronic acid, providing expedited access to a series of nonchiral/chiral coupling products in moderate to good yields. Stereospecific SN2-type coupling is developed for the first time with alkenylboronic acids as pure nucleophiles, offering an attractive alternative to the stereospecific transition-metal-catalyzed C(sp(2))-C(sp(3)) cross-coupling.
authors: State Key Laboratory of Bio-Organic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences , 345 Ling Ling Road, Shanghai 200032, China.
authors: Chengxi
authors: C
authors: Li
authors: State Key Laboratory of Bio-Organic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences , 345 Ling Ling Road, Shanghai 200032, China.
authors: Yuanyuan
authors: Y
authors: Zhang
authors: State Key Laboratory of Bio-Organic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences , 345 Ling Ling Road, Shanghai 200032, China.
authors: Qi
authors: Q
authors: Sun
authors: State Key Laboratory of Bio-Organic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences , 345 Ling Ling Road, Shanghai 200032, China.
authors: Tongnian
authors: T
authors: Gu
authors: State Key Laboratory of Bio-Organic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences , 345 Ling Ling Road, Shanghai 200032, China.
authors: Henian
authors: H
authors: Peng
authors: State Key Laboratory of Bio-Organic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences , 345 Ling Ling Road, Shanghai 200032, China.
authors: Wenjun
authors: W
authors: Tang