title: The prognostic value of serum signal peptide-Cub-Egf domain-containing protein-1 concentrations in acute intracerebral hemorrhage.
abstract: BACKGROUND
  Signal peptide-Cub-Epidermal growth factor domain-containing protein 1 (SCUBE1) in peripheral blood, which is identified as a marker for coagulation, was reported to be an independent predictor of poor outcome in some illnesses. We investigated the clinical utility of serum SCUBE1 in the prognosis of intracerebral hemorrhage (ICH).
  
  
  METHODS
  A total of 128 consecutive patients, admitted to emergency service due to acute ICH, and 128 healthy individuals were included in this prospective study. The patients were followed up until 6months or death. An unfavorable outcome was defined as modified Rankin Scale score>2.
  
  
  RESULTS
  Serum SCUBE1 concentration was markedly higher in patients than in controls and was associated with hematoma volume, National Institutes of Health Stroke Scale (NIHSS) score and blood platelet count. After adjustment for hematoma volume and NIHSS score, it was still related to early neurological deterioration, hematoma growth, 1-week mortality, 6-month mortality, 6-month unfavorable outcome and 6-month overall survival. Additionally, serum SCUBE1 significantly improved areas under receiver operating characteristic curve of hematoma volume and NIHSS score to predict 6-month unfavorable outcome.
  
  
  CONCLUSIONS
  Increased serum SCUBE1 concentrations have close relation to increasing severity and poor prognosis of ICH.
authors: Department of Neurosurgery, The First People's Hospital of Fuyang District of Hangzhou City, 429 Beihuan Road, Fuyang District, Hangzhou 311400, China.
authors: Shen-Zhong
authors: SZ
authors: Qiu
authors: Department of Neurology, The First People's Hospital of Fuyang District of Hangzhou City, 429 Beihuan Road, Fuyang District, Hangzhou 311400, China.
authors: Hong-Xiang
authors: HX
authors: Wang
authors: Department of Neurosurgery, The First People's Hospital of Fuyang District of Hangzhou City, 429 Beihuan Road, Fuyang District, Hangzhou 311400, China.
authors: Jia
authors: J
authors: Shen
authors: Department of Neurosurgery, The First People's Hospital of Fuyang District of Hangzhou City, 429 Beihuan Road, Fuyang District, Hangzhou 311400, China. Electronic address: ianghai@163.com.
authors: Guan-Rong
authors: GR
authors: Zheng
authors: Department of Neurosurgery, The First People's Hospital of Fuyang District of Hangzhou City, 429 Beihuan Road, Fuyang District, Hangzhou 311400, China.
authors: Bin
authors: B
authors: Chen
authors: Department of Neurosurgery, The First People's Hospital of Fuyang District of Hangzhou City, 429 Beihuan Road, Fuyang District, Hangzhou 311400, China.
authors: Jian-Jun
authors: JJ
authors: Huang
authors: Department of Emergency Medicine, The First People's Hospital of Fuyang District of Hangzhou City, 429 Beihuan Road, Fuyang District, Hangzhou 311400, China.
authors: Jian-Bo
authors: JB
authors: Gao
mesh_terms: D000208:Acute Disease; D000368:Aged; D000369:Aged, 80 and over; D002135:Calcium-Binding Proteins; D002543:Cerebral Hemorrhage / Q000097:blood* / Q000175:diagnosis; D005260:Female; D006801:Humans; D008297:Male; D008565:Membrane Proteins / Q000097:blood*; D008875:Middle Aged; D011379:Prognosis; D011446:Prospective Studies
chemical_list: D002135:Calcium-Binding Proteins; D008565:Membrane Proteins; C469998:SCUBE1 protein, human
keywords: Biomarker; Intracerebral hemorrhage; Prognosis; Severity; Signal peptide-Cub-Epidermal growth factor domain-containing protein 1