title: Stryphnosides G-P, 10 new triterpene glycosides from the pericarps of Stryphnodendron fissuratum.
abstract: Ten new triterpene glycosides, stryphnosides G-P (1-10), were isolated from the pericarps of Stryphnodendron fissuratum (Legminosae). The structures of 1-10 were determined based on spectroscopic analyses, including various two-dimensional NMR spectroscopic techniques, and the results of hydrolytic cleavage. The sugar moiety attached to C-3 of the aglycone of 4, 5, and 7-10 is composed of five or six monosaccharides, of which the terminal α-l-arabinosyl unit has a1C4conformation. Compounds 2 and 5 differ from the other isolates in having an α-l-rhamnosyl unit at the C-21 hydroxy group. The cytotoxic activity of 1-10, stryphnosides A-F (11-16), and their aglycones (1a, 11a, 14a, and 16a) against HL-60 cells was also examined.
authors: Department of Medicinal Pharmacognosy, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, Horinouchi 1432-1, Hachiouji, Tokyo 192-0392, Japan. Electronic address: yokosuka@toyaku.ac.jp.
authors: Akihito
authors: A
authors: Yokosuka
authors: Department of Medicinal Pharmacognosy, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, Horinouchi 1432-1, Hachiouji, Tokyo 192-0392, Japan.
authors: Genki
authors: G
authors: Okabe
authors: Department of Medicinal Pharmacognosy, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, Horinouchi 1432-1, Hachiouji, Tokyo 192-0392, Japan.
authors: Satoru
authors: S
authors: Tatsuno
authors: Department of Medicinal Pharmacognosy, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, Horinouchi 1432-1, Hachiouji, Tokyo 192-0392, Japan.
authors: Yoshihiro
authors: Y
authors: Mimaki
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D049109:Cell Proliferation / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D007887:Fabaceae / Q000737:chemistry*; D006027:Glycosides / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D018922:HL-60 Cells; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D014315:Triterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology
chemical_list: D000970:Antineoplastic Agents; D006027:Glycosides; D014315:Triterpenes
keywords: Cytotoxic activity; HL-60 cells; Legminosae; Stryphnodendron fissuratum; Triterpene glycosides