title: Age‑dependent increase in the expression of antioxidant‑like protein‑1 in the gerbil hippocampus.
abstract: Antioxidant-like protein-1 (AOP-1) reduces the intracellular level of reactive oxygen species. In the present study, the age‑related change in AOP‑1 expression in the hippocampus among young, adult and aged gerbils was compared using western blot analysis and immunohistochemistry. The results demonstrated that the protein expression of AOP‑1 was gradually and significantly increased in the hippocampus during the normal aging process. In addition, the age‑dependent increase in AOP‑1 immunoreactivity was also observed in pyramidal neurons of the hippocampus proper; however, in the dentate gyrus, AOP‑1 immunoreactivity was not altered during the normal aging process. These results indicated that the expression of AOP‑1 is significantly increased in the hippocampus proper, but not in the dentate gyrus, during the normal aging process.
authors: Department of Pharmacy, College of Pharmacy, Dankook University, Cheonan, South Chungcheong 31116, Republic of Korea.
authors: Jin-A
authors: JA
authors: Park
authors: Department of Neurobiology, School of Medicine, Kangwon National University, Chuncheon, Gangwon 24341, Republic of Korea.
authors: Joon Ha
authors: JH
authors: Park
authors: Department of Biomedical Science, Research Institute of Bioscience and Biotechnology, Hallym University, Chuncheon, Gangwon 24252, Republic of Korea.
authors: Ji Hyeon
authors: JH
authors: Ahn
authors: Division of Food Biotechnology, School of Biotechnology, Kangwon National University, Chuncheon, Gangwon 24341, Republic of Korea.
authors: Jong-Dai
authors: JD
authors: Kim
authors: Department of Neurobiology, School of Medicine, Kangwon National University, Chuncheon, Gangwon 24341, Republic of Korea.
authors: Moo-Ho
authors: MH
authors: Won
authors: Department of Pharmacy, College of Pharmacy, Dankook University, Cheonan, South Chungcheong 31116, Republic of Korea.
authors: Choong-Hyun
authors: CH
authors: Lee
mesh_terms: D000375:Aging; D000818:Animals; D018891:Dentate Gyrus / Q000502:physiology / Q000648:ultrastructure; D005849:Gerbillinae; D006624:Hippocampus / Q000502:physiology* / Q000648:ultrastructure; D008297:Male; D061105:Peroxiredoxin III / Q000032:analysis / Q000378:metabolism*
chemical_list: D061105:Peroxiredoxin III