title: Distribution of Silver Nanoparticles to Breast Milk and Their Biological Effects on Breast-Fed Offspring Mice.
abstract: Recent rodent studies have shown that nanoparticles are distributed to breast milk, and more-detailed safety information regarding nanoparticle consumption by lactating mothers is required. Here, we used mice to investigate the safety of nanoparticle use during lactation. When Ag and Au nanoparticles were intravenously administered to lactating mice, the nanoparticles were distributed to breast milk without producing apparent damage to the mammary gland, and the amount of Ag nanoparticles distributed to breast milk increased with decreasing particle size. Orally administered Ag nanoparticles were also distributed to breast milk and subsequently to the brains of breast-fed pups. Ten-nanometer Ag nanoparticles were retained longer in the pups' brains than in their livers and lungs. Nevertheless, no significant behavioral changes were observed in offspring breast-fed by dams that had received orally administered 10 nm Ag nanoparticles. These data provide basic information for evaluating the safety of nanoparticle use during lactation.
authors: Yuki
authors: Y
authors: Morishita
authors: Vaccine Creation Project, BIKEN Innovative Vaccine Research Alliance Laboratories, Research Institute for Microbial Diseases, Osaka University , 3-1 Yamadaoka, Suita, Osaka 565-0871, Japan.|BIKEN Center for Innovative Vaccine Research and Development, The Research Foundation for Microbial Diseases of Osaka University , 3-1 Yamadaoka, Suita, Osaka 565-0871, Japan.
authors: Yasuo
authors: Y
authors: Yoshioka
authors: Yuya
authors: Y
authors: Takimura
authors: Yuki
authors: Y
authors: Shimizu
authors: Yuki
authors: Y
authors: Namba
authors: Nao
authors: N
authors: Nojiri
authors: Takuya
authors: T
authors: Ishizaka
authors: Section of Behavior Patterns, Center for Genetic Analysis of Behavior, National Institute for Physiological Sciences , 38 Aza-Nishigo-naka, Myodaiji-cho, Okazaki, Aichi 444-8585, Japan.
authors: Keizo
authors: K
authors: Takao
authors: Department of Drug Delivery Research, Graduate School of Pharmaceutical Sciences, Kyoto University , 46-29 Yoshida Shimoadachi-cho, Sakyo-ku, Kyoto 606-8501, Japan.
authors: Fumiyoshi
authors: F
authors: Yamashita
authors: Department of Pharmacology, Graduate School of Dentistry, Osaka University , 1-8 Yamadaoka, Suita, Osaka 565-0871, Japan.
authors: Kazuhiro
authors: K
authors: Takuma
authors: Yukio
authors: Y
authors: Ago
authors: Kazuya
authors: K
authors: Nagano
authors: Yohei
authors: Y
authors: Mukai
authors: Haruhiko
authors: H
authors: Kamada
authors: Shin-Ichi
authors: S
authors: Tsunoda
authors: Shigeru
authors: S
authors: Saito
authors: Toshio
authors: T
authors: Matsuda
authors: Department of Drug Delivery Research, Graduate School of Pharmaceutical Sciences, Kyoto University , 46-29 Yoshida Shimoadachi-cho, Sakyo-ku, Kyoto 606-8501, Japan.
authors: Mitsuru
authors: M
authors: Hashida
authors: Section of Behavior Patterns, Center for Genetic Analysis of Behavior, National Institute for Physiological Sciences , 38 Aza-Nishigo-naka, Myodaiji-cho, Okazaki, Aichi 444-8585, Japan.|Division of Systems Medical Science, Institute for Comprehensive Medical Science, Fujita Health University , 1-98 Dengakugakubo, Kutsukake-cho, Toyoake, Aichi 470-1192, Japan.
authors: Tsuyoshi
authors: T
authors: Miyakawa
authors: Kazuma
authors: K
authors: Higashisaka
authors: Yasuo
authors: Y
authors: Tsutsumi
mesh_terms: D000818:Animals; D001522:Behavior, Animal; D001921:Brain; D005260:Female; D007774:Lactation; D008099:Liver; D053768:Metal Nanoparticles / Q000032:analysis*; D051379:Mice; D008892:Milk; D012834:Silver; D014018:Tissue Distribution
chemical_list: D012834:Silver
keywords: breast milk; distribution; gold nanoparticle; infant; lactation; silver nanoparticle; toxicity