title: Bone mineral density in women treated for various types of gynecological cancer.
abstract: OBJECTIVE
  Patients with gynecologic cancer frequently experience bone loss due to cancer treatments, including bilateral oophorectomy, chemotherapy and radiotherapy. This study evaluated treatment-associated changes in bone mineral density (BMD) in women with gynecologic cancer and compared changes among patients with different types of gynecologic cancer.
  
  
  METHODS
  BMD of the lumbar spine and femur was retrospectively analyzed using dual-energy X-ray absorptiometry in 118 women who underwent treatment for gynecological cancers and 132 women without gynecologic cancers. The cohort included 55 women with cervical cancer who underwent surgery followed by adjuvant chemotherapy and/or radiation therapy, 33 with endometrial cancer (EC) who underwent surgery followed by adjuvant radiation therapy and 30 with ovarian cancer who underwent bilateral oophorectomy followed by adjuvant platinum-based chemotherapy. Lumbar spine and femoral neck BMD were assessed at baseline and 12 months after treatment. Areal BMD, expressed as grams of mineral/cm2scanned, was compared with that in young healthy women (T-score).
  
  
  RESULTS
  Demographic characteristics and pretreatment BMDs, including T-scores, did not differ among cancer types. After adjustment for factors that can affect T-score, cancer type affected change in T-score 12 months after treatment. After adjustment for pretreatment age, parity, BMI and T-score, T-score 12 months after treatment was significantly lower in the EC than in the other groups.
  
  
  CONCLUSIONS
  Women treated for gynecological cancer, particularly those with EC who undergo bilateral oophorectomy followed by adjuvant radiation therapy or chemotherapy, should be managed in a timely manner to prevent or minimize bone loss.
authors: Department of Obstetrics and Gynecology, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang, Korea.
authors: Suk Woo
authors: SW
authors: Lee
authors: East-West Medical Research Institute, Kyung Hee University, Seoul, Korea.
authors: Seung Geun
authors: SG
authors: Yeo
authors: Department of Preventive Medicine, School of Medicine, Kyung Hee University, Seoul, Korea.
authors: In-Hwan
authors: IH
authors: Oh
authors: Eulji University, School of Medicine, Daejeon, Korea.
authors: Joon Hyung
authors: JH
authors: Yeo
authors: Department of Obstetrics and Gynecology, St. Vincent's Hospital, College of Medicine, The Catholic University of Korea, Suwon, Korea.
authors: Dong Choon
authors: DC
authors: Park
mesh_terms: D000328:Adult; D015519:Bone Density / Q000235:genetics*; D005260:Female; D005833:Genital Neoplasms, Female / Q000628:therapy*; D006801:Humans; D008875:Middle Aged
keywords: BMD; gynecologic cancer