title: Histopathologic findings in uteri and ovaries collected from clinically healthy dogs at elective ovariohysterectomy: a cross-sectional study.
abstract: Opinions on ovariohysterectomy (OHE) of bitches vary depending on region and country. In this descriptive, prospective cross-sectional study, uterine tracts and ovaries exhibiting gross pathologic findings (n = 76) were collected post-surgery from a reference population of 3,600 bitches (2.11% incidence) that underwent elective OHE during September to November 2013 and evaluated by histopathology examination. Data were evaluated by using descriptive statistics and chi-squared tests. Bitches were of crossbred background with average age 5 years (range 0.6-8.0 years) and most were nulliparous (69.7%) with no anamnesis of reproductive diseases (81.6%). Frequencies of proestrus, estrus, and diestrus were 42.1%, 6.6%, and 19.7%, respectively. The presence of mammary gland masses (5.3%) significantly correlated with histopathologic findings in ovaries and age of the bitch (p＜ 0.05). Predominant uterine histopathologies included cystic endometrial hyperplasia, periglandular fibrosis, lymphoplasmocytary endometritis, and adenomyosis (19.7%, 14.5%, 4.0%, and 2.6%, respectively). In ovaries, hyperplasia of rete ovarii, follicular cysts, oophoritis, adenoma of the rete ovarii, cysts of superficial structures, and granulosa cell tumors (10.5%, 10.5%, 7.9%, 4.0%, 2.6%, and 2.6%, respectively) were observed. The results reveal the presence of subclinical pathologies in healthy bitches, suggesting that OHE at an early age is beneficial for prevention of reproductive pathologies.
authors: INCA-CES Research Group, School of Veterinary Medicine and Zootechny, CES University, Medellin 050021, Colombia.
authors: Daniel
authors: D
authors: Maya-Pulgarin
authors: INCA-CES Research Group, School of Veterinary Medicine and Zootechny, CES University, Medellin 050021, Colombia.|Veterinary Teaching Hospital, CES University, Envigado 0555427, Colombia.
authors: María Soledad
authors: MS
authors: Gonzalez-Dominguez
authors: Research Group on Veterinary Sciences Centauro School of Veterinary Medicine, Faculty of Agrarian Sciences, University of Antioquia, Medellin 050010, Colombia.|Laboratory of Veterinary Pathology, School of Veterinary Medicine, Faculty of Agrarian Sciences, University of Antioquia, Medellin 050010, Colombia.
authors: Diego
authors: D
authors: Aranzazu-Taborda
authors: INCA-CES Research Group, School of Veterinary Medicine and Zootechny, CES University, Medellin 050021, Colombia.
authors: Natalia
authors: N
authors: Mendoza
authors: Research Group on Veterinary Sciences Centauro School of Veterinary Medicine, Faculty of Agrarian Sciences, University of Antioquia, Medellin 050010, Colombia.
authors: Juan Guillermo
authors: JG
authors: Maldonado-Estrada
mesh_terms: D000818:Animals; D003430:Cross-Sectional Studies; D004283:Dog Diseases / Q000473:pathology; D004285:Dogs; D004714:Endometrial Hyperplasia / Q000473:pathology / Q000662:veterinary; D004716:Endometritis / Q000473:pathology / Q000662:veterinary; D005260:Female; D007044:Hysterectomy / Q000379:methods / Q000662:veterinary*; D010049:Ovarian Diseases / Q000473:pathology / Q000662:veterinary; D010051:Ovarian Neoplasms / Q000473:pathology / Q000662:veterinary; D010052:Ovariectomy / Q000379:methods / Q000662:veterinary*; D010053:Ovary / Q000473:pathology* / Q000601:surgery; D014599:Uterus / Q000473:pathology* / Q000601:surgery
keywords: canine neoplastic disease; canine ovarian pathology; canine uterine pathology; cystic endometrial hyperplasia