title: Growth differentiation factor 11 (GDF11) - a promising anti-ageing factor - is highly concentrated in platelets.
abstract: Recent research suggests that growth differentiation factor 11 (GDF11) could reverse age-related diseases and that its blood concentration decreases with age. This poses plasma from young donors as a therapeutic GDF11 source to treat age-related diseases. In addition, the tissue source of circulating GDF11 remains unknown. We analysed GDF11 levels in paired samples of serum, plasma and platelet lysate (PL) from 23 volunteers. Plasma and PL were collected by plateletpheresis. Here, we show that GDF11 is highly concentrated in platelets and that the circulating levels reported in previous studies could be biased as a result of serum sample manipulation.
authors: Haematology Department, Hospital Universitario Puerta de Hierro-Majadahonda, Majadahonda, Spain.
authors: J L
authors: JL
authors: Bueno
authors: Immunology Department, Hospital Universitario Puerta de Hierro-Majadahonda, Majadahonda, Spain.
authors: M
authors: M
authors: Ynigo
authors: Haematology Department, Hospital Universitario Puerta de Hierro-Majadahonda, Majadahonda, Spain.
authors: C
authors: C
authors: de Miguel
authors: Haematology Department, Hospital Universitario Puerta de Hierro-Majadahonda, Majadahonda, Spain.
authors: R M
authors: RM
authors: Gonzalo-Daganzo
authors: Centro de Transfusión, Madrid, Spain.
authors: A
authors: A
authors: Richart
authors: Inmunogenetics & Histocompatibility, Instituto de Investigación Sanitaria Puerta de Hierro.
authors: C
authors: C
authors: Vilches
authors: Haematology Department, Hospital Universitario Puerta de Hierro-Majadahonda, Majadahonda, Spain.
authors: C
authors: C
authors: Regidor
authors: Haematology Department, Hospital Universitario Puerta de Hierro-Majadahonda, Majadahonda, Spain.
authors: J A
authors: JA
authors: García-Marco
authors: Centro de Transfusión, Madrid, Spain.
authors: E
authors: E
authors: Flores-Ballester
authors: Haematology Department, Hospital Universitario Puerta de Hierro-Majadahonda, Majadahonda, Spain.
authors: J R
authors: JR
authors: Cabrera
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001792:Blood Platelets / Q000378:metabolism*; D019485:Bone Morphogenetic Proteins / Q000378:metabolism*; D055412:Growth Differentiation Factors / Q000378:metabolism*; D006801:Humans; D008875:Middle Aged; D010983:Plateletpheresis; D055815:Young Adult
chemical_list: D019485:Bone Morphogenetic Proteins; C492266:GDF11 protein, human; D055412:Growth Differentiation Factors
keywords: Platelet Rich Plasma (PRP); apheresis; cytokine; plasma; regenerative medicine ageing