title: The motility of Entamoeba histolytica: finding ways to understand intestinal amoebiasis.
abstract: The pathogenic amoeba Entamoeba histolytica is able to migrate within various compartments of the human body. The present article reviews progress in understanding the mechanisms of cell motility in E. histolytica during human intestinal invasion and, in particular, how the three-dimensional characteristics of the environment regulate the parasite's behaviour. The amoeboid mode of migration that applies to E. histolytica's displacements on two-dimensional surfaces is also expected to apply to the three-dimensional environment in the human intestine although several unknown, distinct modalities may be involved. Recent advances in the field of tissue engineering have provided clues on how the construction of a human colon model could help us to understand the host's intestinal physiology and its changes following amoebic infection.
authors: Institut Pasteur, Unité d'Analyse d'Images Biologiques, 25 Rue du Dr Roux, F-75015 Paris, France; Centre National de la Recherche Scientifique, CNRS UMR3691, 25 Rue du Dr Roux, F-75015 Paris, France; Instituto Mexicano del Seguro Social, Research Unit in Reproductive Medicine, Unidad Médica de Alta Especialidad-Hospital de Ginecobstetricia No. 4 "Luis Castelazo Ayala", Mexico D.F., Mexico.
authors: Arturo
authors: A
authors: Aguilar-Rojas
authors: Institut Pasteur, Unité d'Analyse d'Images Biologiques, 25 Rue du Dr Roux, F-75015 Paris, France; Centre National de la Recherche Scientifique, CNRS UMR3691, 25 Rue du Dr Roux, F-75015 Paris, France.
authors: Jean-Christophe
authors: JC
authors: Olivo-Marin
authors: Institut Pasteur, Unité d'Analyse d'Images Biologiques, 25 Rue du Dr Roux, F-75015 Paris, France; Centre National de la Recherche Scientifique, CNRS-ERL9195, 25 Rue du Dr Roux, F-75015 Paris, France. Electronic address: nancy.guillen@pasteur.fr.
authors: Nancy
authors: N
authors: Guillen
mesh_terms: D000818:Animals; D003106:Colon / Q000469:parasitology / Q000503:physiopathology; D004404:Dysentery, Amebic / Q000469:parasitology*; D004748:Entamoeba histolytica / Q000472:pathogenicity / Q000502:physiology*; D006801:Humans; D007422:Intestines / Q000469:parasitology* / Q000503:physiopathology*; D009068:Movement; D009924:Organ Culture Techniques; D023822:Tissue Engineering