title: Distribution of LDL subgroups in patients with hyperlipidemia.
abstract: OBJECTIVE
  Low-density lipoproteins (LDLs) have been shown to be a major risk factor for coronary artery disease. Multiple distinct subspecies have been identified among LDL particles on the basis of differences in size, density, and chemical composition. Particles with a diameter of <25.5 nm are defined as small dense LDL (sdLDL) and have been shown to be associated with increased risk of coronary disease. Subjects with predominance of sdLDL (pattern B) tend to have higher levels of triglyceride (TG) and lower levels of high-density lipoprotein cholesterol (HDL-C). In this study, we investigated the distribution of LDL subgroups in subjects with different types of hyperlipidemia, such as hypertriglyceridemia (hyperTG), hypercholesterolemia (hyperCHO), and combined hyperlipidemia (HL).
  
  
  METHODS
  We used gradient gel electrophoresis and a precipitation method with heparin-magnesium reagent to determine LDL subgroups.
  
  
  RESULTS
  It was found that there was a significant (P < 0.02) association between the lipid panel and LDL subgroups. The percentage of sdLDL in all HL groups was higher than in controls, and the ratio of sdLDL was highest in patients with hyperTG.
  
  
  CONCLUSIONS
  The predominance of sdLDL is closely related to hyperTG and low HDL-C levels.
authors: Department of Medical Biochemistry, Faculty of Medicine, Dokuz Eylül University, İzmir, Turkey.
authors: Ebru
authors: E
authors: Taylan
authors: Department of Medical Biochemistry, Faculty of Medicine, Dokuz Eylül University, İzmir, Turkey.
authors: Emine Pınar
authors: EP
authors: Tuncel
mesh_terms: D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D003324:Coronary Artery Disease; D006801:Humans; D006949:Hyperlipidemias; D008077:Lipoproteins, LDL; D012307:Risk Factors; D014280:Triglycerides
chemical_list: D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D008077:Lipoproteins, LDL; D014280:Triglycerides
keywords: Hyperlipidemia; atherosclerosis; small dense low-density lipoproteins.