title: Growth of HIV-Infected Children in the Early Stage of Antiretroviral Treatment: A Retrospective Cohort Study in China.
abstract: Malnutrition and human immunodeficiency virus (HIV)-related complications are commonly seen in HIV-infected children, and these have been shown in high-prevalent areas such as Africa. Antiviral therapy (ART) has notably controlled disease progression, whereas it effectively reverses underweight and growth retardation in HIV-infected children. This study was conducted to evaluate the growth status after initiation of ART in HIV-infected children in China. A retrospective cohort study was conducted based on the National Science and Technology Major Project. HIV-infected children who initiated antiretroviral treatment between January 1st, 2012 and December 31st, 2012 were followed up to December 31st, 2014. Z-scores of height and weight were calculated by WHO Anthro (plus). Linear mixed-effects models were used to model trajectories of weight- and height-for-age Z-scores. Seven hundred forty-four participants enrolled in the study, with 585 participants and 712 participants who had WAZ (weight-for-age Z-score) and HAZ (height-for-age Z-score), respectively, before initiation of ART. Among them, 125 (21.4%) were underweight and 301 (42.3%) were stunted. After treatment, among the 125 underweight children, WAZ improved in 69 patients, regained more than -2 on average. Among the 301 stunted children, HAZ improved in 123 patients, regained more than -2 on average. WAZ improved for the first 6 months by 0.052 units each month and then stabilized, whereas HAZ consistently improved by 0.014 units each month over time. Antiretroviral treatment reversed the adverse effects of HIV to some degree. Early diagnosis and treatment, with an effective nutrition program, is necessary to improve malnutrition further.
authors: 1 National Centre for AIDS/STD Control and Prevention, Chinese Centre for Disease Control and Prevention , Beijing, China .|2 Jiangsu Provincial Centre for Disease Control and Prevention , Nanjing, China .
authors: Ran
authors: R
authors: Hu
authors: 1 National Centre for AIDS/STD Control and Prevention, Chinese Centre for Disease Control and Prevention , Beijing, China .
authors: Weiwei
authors: W
authors: Mu
authors: 3 Psychology Department, Public Health Institute, Harbin Medical University , Harbin, China .
authors: Xin
authors: X
authors: Sun
authors: 4 Beijing Youan Hospital, Capital Medical University , Beijing, China .
authors: Hao
authors: H
authors: Wu
authors: 5 Beijing Ditan Hospital, Capital Medical University , Beijing, China .
authors: Lin
authors: L
authors: Pang
authors: 5 Beijing Ditan Hospital, Capital Medical University , Beijing, China .
authors: Liming
authors: L
authors: Wang
authors: 6 The Sixth People's Hospital of Zhengzhou , Zhengzhou, China .
authors: Qingxia
authors: Q
authors: Zhao
authors: 1 National Centre for AIDS/STD Control and Prevention, Chinese Centre for Disease Control and Prevention , Beijing, China .
authors: Yasong
authors: Y
authors: Wu
authors: 1 National Centre for AIDS/STD Control and Prevention, Chinese Centre for Disease Control and Prevention , Beijing, China .
authors: Decai
authors: D
authors: Zhao
authors: 1 National Centre for AIDS/STD Control and Prevention, Chinese Centre for Disease Control and Prevention , Beijing, China .
authors: Meiling
authors: M
authors: Chen
authors: 1 National Centre for AIDS/STD Control and Prevention, Chinese Centre for Disease Control and Prevention , Beijing, China .
authors: Ye
authors: Y
authors: Ma
authors: 1 National Centre for AIDS/STD Control and Prevention, Chinese Centre for Disease Control and Prevention , Beijing, China .|5 Beijing Ditan Hospital, Capital Medical University , Beijing, China .
authors: Fujie
authors: F
authors: Zhang
mesh_terms: D019380:Anti-HIV Agents / Q000008:administration & dosage*; D023241:Antiretroviral Therapy, Highly Active; D001827:Body Height / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects; D002648:Child; D002675:Child, Preschool; D002681:China / Q000453:epidemiology; D005260:Female; D006128:Growth / Q000187:drug effects*; D006130:Growth Disorders / Q000503:physiopathology / Q000821:virology; D015658:HIV Infections / Q000150:complications / Q000188:drug therapy* / Q000208:ethnology; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D015995:Prevalence; D012189:Retrospective Studies; D016896:Treatment Outcome
chemical_list: D019380:Anti-HIV Agents