title: Intraarticular Ankaferd blood stopper application increases cartilagedegeneration: an experimental study.
abstract: OBJECTIVE
  Ankaferd blood stopper (ABS) is a mixture of certain ratios of 5 different plant roots (Thymus vulgaris, Glycyrrhiza glabra, Vitis vinifera, Alpinia officinarum, and Urtica dioica). The aim of this study is to evaluate the histopathological effects of ABS on articular cartilage in vitro.
  
  
  METHODS
  Twenty-one albino Sprague Dawley rats were randomly allocated to 3 groups: 0.1 mL of saline was injected in the first group, 0.1 mL of ABS was injected in the second group, and 0.1 mL of blood and 0.1 mL of ABS were injected in the third group. One month later all rats were sacrificed. Specimens were obtained for histopathological evaluation.
  
  
  RESULTS
  Significant results were detected in the groups with respect to International Cartilage Repair Society and synovial proliferation scores (P < 0.05 and P < 0.01). According to inflammatory cell infiltration and fibrin formation scores, there was no significant difference between group 1 and group 2 (P < 0.01), although there was significant difference between group 3 and the other groups (P > 0.05).
  
  
  CONCLUSIONS
  ABS and hemarthrosis had toxic effects on knee cartilage. The side effects were increased with the combination of hemarthrosis and ABS. As a result, ABS had unexpected effects on experimental hemarthrosis.
authors: Department of Orthopedics and Traumatology, Haseki Training and Research Hospital, İstanbul, Turkey.
authors: İbrahim
authors: İ
authors: Kaya
authors: Department of Orthopedics and Traumatology, Dr. Lütfi Kırdar Kartal Training and Research Hospital, İstanbul, Turkey.
authors: Deniz
authors: D
authors: Gülabi
authors: Department of Orthopedics and Traumatology, Haseki Training and Research Hospital, İstanbul, Turkey.
authors: Murat
authors: M
authors: Yilmaz
authors: Department of Orthopedics and Traumatology, Ağrı State Hospital, Ağrı, Turkey.
authors: Ali
authors: A
authors: Baş
authors: Department of Orthopedics and Traumatology, Dr. Lütfi Kırdar Kartal Training and Research Hospital, İstanbul, Turkey.
authors: Gültekin Sıtkı Çeçen
authors: GS
authors: Çeçen
authors: Department of Orthopedics and Traumatology, Haseki Training and Research Hospital, İstanbul, Turkey.
authors: Nurullah
authors: N
authors: Şener
mesh_terms: D000818:Animals; D006035:Glycyrrhiza; D006490:Hemostatics; D010936:Plant Extracts / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D017208:Rats, Wistar
chemical_list: D006490:Hemostatics; D010936:Plant Extracts; C539751:ankaferd blood stopper
keywords: Ankaferd; Hemarthrosis; cartilage