title: Treatment of infraorbital dark circles using 694-nm fractional Q-switched ruby laser.
abstract: The objective of this study was to evaluate the efficacy and safety of using a 694-nm fractional Q-switched ruby laser to treat infraorbital dark circles. Thirty women with infraorbital dark circles (predominant color: dark/brown) participated in this open-labeled study. The participants received eight sessions of 694-nm fractional Q-switched ruby laser treatment using a fluence of 3.0-3.5 J/cm2, at an interval of 7 days. The melanin deposition in the lesional skin was observed in vivo using reflectance confocal microscopy (RCM). The morphological changes were evaluated using a global evaluation, an overall self-assessment, and a Mexameter. Twenty-eight of the 30 patients showed global improvements that they rated as excellent or good. Twenty-six patients rated their overall satisfaction as excellent or good. The melanin index indicated a substantial decrease from 240.44 (baseline) to 194.56 (P < 0.05). The RCM results showed a dramatic decrease in melanin deposition in the upper dermis. The adverse effects were minimal. The characteristic finding of dark/brown infraorbital dark circles is caused by increased melanin deposition in the upper dermis. The treatment of these infraorbital dark circles using a 694-nm fractional QSR laser is safe and effective.
authors: Department of Dermatology, No. 1 Hospital of China Medical University, 155N. Nanjing Street, Shenyang, 110001, People's Republic of China. xutian5151@163.com.
authors: Tian-Hua
authors: TH
authors: Xu
authors: Department of Dermatology, No. 1 Hospital of China Medical University, 155N. Nanjing Street, Shenyang, 110001, People's Republic of China.
authors: Yuan-Hong
authors: YH
authors: Li
authors: Healthy Skin Dermatology, Tucson, AZ, USA.
authors: John Z S
authors: JZ
authors: Chen
authors: Department of Dermatology, No. 1 Hospital of China Medical University, 155N. Nanjing Street, Shenyang, 110001, People's Republic of China.
authors: Xing-Hua
authors: XH
authors: Gao
authors: Department of Dermatology, No. 1 Hospital of China Medical University, 155N. Nanjing Street, Shenyang, 110001, People's Republic of China. chenhd@cae.cn.
authors: Hong-Duo
authors: HD
authors: Chen
mesh_terms: D000328:Adult; D002681:China; D005123:Eye; D005260:Female; D006801:Humans; D053844:Lasers, Solid-State / Q000627:therapeutic use*; D028022:Low-Level Light Therapy / Q000379:methods*; D008543:Melanins / Q000528:radiation effects*; D008875:Middle Aged; D017060:Patient Satisfaction
chemical_list: D008543:Melanins
keywords: 694-nm fractional Q-switched ruby laser; Infraorbital dark circles; Reflectance confocal microscopy