title: Lymphocytic Interstitial Pneumonia.
abstract: Lymphocytic interstitial pneumonia (LIP) is a rare lung disease on the spectrum of benign pulmonary lymphoproliferative disorders. LIP is frequently associated with connective tissue diseases or infections. Idiopathic LIP is rare; every attempt must be made to diagnose underlying conditions when LIP is diagnosed. Computed tomography of the chest in patients with LIP may reveal ground-glass opacities, centrilobular and subpleural nodules, and randomly distributed thin-walled cysts. Demonstrating polyclonality with immunohistochemistry is the key to differentiating LIP from lymphoma. The 5-year mortality remains between 33% and 50% and is likely to vary based on the underlying disease process.
authors: Department of Medicine, Norton Thoracic Institute, St. Joseph's Hospital and Medical Center, Creighton University School of Medicine, Phoenix Regional Campus, 500 West Thomas Road, Suite 500, Phoenix, AZ 85013, USA.
authors: Tanmay S
authors: TS
authors: Panchabhai
authors: Department of Anatomic Pathology, Pathology and Laboratory Medicine Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA; Department of Pathology, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University School of Medicine, Cleveland Clinic, 9500 Euclid Avenue, L25, Cleveland, OH 44195, USA.
authors: Carol
authors: C
authors: Farver
authors: Department of Pulmonary Medicine, Respiratory Institute, Cleveland Clinic, 9500 Euclid Avenue, A90, Cleveland, OH 44195, USA. Electronic address: highlak@ccf.org.
authors: Kristin B
authors: KB
authors: Highland
mesh_terms: D018893:Bronchoalveolar Lavage; D015897:Comorbidity; D003240:Connective Tissue Diseases / Q000276:immunology; D004406:Dysgammaglobulinemia / Q000276:immunology*; D020031:Epstein-Barr Virus Infections / Q000276:immunology*; D015658:HIV Infections / Q000276:immunology*; D006801:Humans; D008168:Lung / Q000000981:diagnostic imaging / Q000473:pathology; D008171:Lung Diseases / Q000175:diagnosis / Q000276:immunology / Q000473:pathology; D017563:Lung Diseases, Interstitial / Q000175:diagnosis / Q000276:immunology* / Q000473:pathology; D008232:Lymphoproliferative Disorders / Q000175:diagnosis / Q000276:immunology / Q000473:pathology; D019310:Pseudolymphoma / Q000175:diagnosis / Q000276:immunology / Q000473:pathology; D012859:Sjogren's Syndrome / Q000276:immunology*; D014057:Tomography, X-Ray Computed
keywords: Cystic lung disease; Interstitial lung disease; Interstitial lung disease in HIV-positive patients; Interstitial lung disease in Sjögren syndrome; Polyclonal lymphoid lung infiltrates; Pseudolymphoma; Pulmonary lymphoproliferative disorders