title: Comparison of immune persistence among inactivated and live attenuated hepatitis a vaccines 2 years after a single dose.
abstract: Compare immune persistence from one dose of each of 3 different hepatitis A vaccines when given to school-age children: a domestic, live attenuated hepatitis A vaccine (H2 vaccine); a domestic inactivated hepatitis A vaccine (Healive®); and an imported, inactivated hepatitis A vaccine (Havrix®),.
  
  
  
  School-age children were randomized into 1 of 4 groups to receive a single dose of a vaccine: H2 vaccine, Healive®, Havrix®, or hepatitis B vaccine [control]. Serum samples were collected 12 and 24 months after vaccination for measurement of anti-HAV IgG using microparticle enzyme immunoassay. Seropositivity was defined as ≥ 20 mUI/ml. We compared groups on seropositivity and geometric mean concentration (GMC).
  
  
  
  Seropositive rates for the H2, Healive®, Havrix®, and control groups were 64%, 94.4%, 73%, and 1.0%, respectively, 12-months post-vaccination; and 63%, 95.6%, 72%, and 1.0%, respectively 24-months post-vaccination. Seropositivity was greater for Healive® than for H2 and Havrix® at 12 months (p-values < 0.001) and 24 months (p-values < 0.0001). Average GMCs for the H2, Healive®, Havrix®, and control groups, in mIU/ml, were 29.7, 81.0, 36.4, and 2.9, respectively at 12 months, and 30.9, 112.2, 44.3, and 2.9, respectively, at 24 months. GMCs were greater for Healive® than for H2 and Havrix® at 12 months (p-values < 0.0001 and < 0.001, respectively) and 24 months (p-values < 0.001). No statistically significant differences in seropositivity or GMC were found within groups between 12 and 24 months.
  
  
  
  Immunity persisted 24 months after a single dose of inactivated hepatitis A vaccine and live attenuated hepatitis A vaccine.
authors: a GanSu Provincial Center for Disease Control and Prevention , Lanzhou , China.
authors: Xiaoshu
authors: X
authors: Zhang
authors: a GanSu Provincial Center for Disease Control and Prevention , Lanzhou , China.
authors: Jing
authors: J
authors: An
authors: a GanSu Provincial Center for Disease Control and Prevention , Lanzhou , China.
authors: Aixia
authors: A
authors: Tu
authors: a GanSu Provincial Center for Disease Control and Prevention , Lanzhou , China.
authors: Xuefeng
authors: X
authors: Liang
authors: b Chinese Center for Disease Control and Prevention , Beijing , China.
authors: Fuqiang
authors: F
authors: Cui
authors: b Chinese Center for Disease Control and Prevention , Beijing , China.
authors: Hui
authors: H
authors: Zheng
authors: a GanSu Provincial Center for Disease Control and Prevention , Lanzhou , China.
authors: Yu
authors: Y
authors: Tang
authors: a GanSu Provincial Center for Disease Control and Prevention , Lanzhou , China.
authors: Jianfeng
authors: J
authors: Liu
authors: a GanSu Provincial Center for Disease Control and Prevention , Lanzhou , China.
authors: Xuxia
authors: X
authors: Wang
authors: a GanSu Provincial Center for Disease Control and Prevention , Lanzhou , China.
authors: Ningjing
authors: N
authors: Zhang
authors: a GanSu Provincial Center for Disease Control and Prevention , Lanzhou , China.
authors: Hui
authors: H
authors: Li
mesh_terms: D002648:Child; D004311:Double-Blind Method; D005260:Female; D006506:Hepatitis A / Q000517:prevention & control*; D035922:Hepatitis A Antibodies / Q000097:blood*; D022362:Hepatitis A Vaccines / Q000008:administration & dosage* / Q000276:immunology*; D006801:Humans; D007124:Immunoenzyme Techniques; D007074:Immunoglobulin G / Q000097:blood; D008297:Male; D013997:Time Factors; D014613:Vaccines, Attenuated / Q000008:administration & dosage / Q000276:immunology; D015164:Vaccines, Inactivated / Q000008:administration & dosage / Q000276:immunology
chemical_list: D035922:Hepatitis A Antibodies; D022362:Hepatitis A Vaccines; D007074:Immunoglobulin G; D014613:Vaccines, Attenuated; D015164:Vaccines, Inactivated
keywords: Hepatitis A vaccine; immune persistence; single dose