title: Electron beam irradiation crosslinked hydrogels based on tyramine conjugated gum tragacanth.
abstract: In the present study, electron beam irradiation was applied to prepare a chemically crosslinked hydrogel based on tyramine conjugated gum tragacanth. Then, the gel content, swelling behavior and cytotoxicity of the hydrogels were evaluated. The gel content of the hydrogels was in the range of 75-85%. Equilibrium swelling degree of the hydrogels decreased from 51 to 14 with increasing polymer concentration and irradiation dose. Moisture retention capability of the hydrogels after 5h incubation at 37°C was in the range of 45-52 that is comparable with of commercial hydrogels. The cytotoxicity analysis showed the good biocompatibility of hydrogels. These results indicated that electron beam irradiation is a promising method to prepare chemically crosslinked tyramine conjugated gum tragacanth hydrogels for biomedical applications. Also, the versatility of electron beam irradiation for crosslinking of a variety of polymers possessing tyramine groups was demonstrated.
authors: Central Iran Research Complex, Nuclear Science and Technology Research Institute, Yazd, Iran,. Electronic address: m.tavakol@modares.ac.ir.
authors: Moslem
authors: M
authors: Tavakol
authors: Central Iran Research Complex, Nuclear Science and Technology Research Institute, Yazd, Iran.
authors: Saeedeh
authors: S
authors: Dehshiri
authors: Biomedical Engineering Division, Faculty of Chemical Engineering, Tarbiat Modares University, Tehran, Iran,. Electronic address: evf@modares.ac.ir.
authors: Ebrahim
authors: E
authors: Vasheghani-Farahani
mesh_terms: D018938:Caco-2 Cells; D004583:Electrons; D006801:Humans; D020100:Hydrogels / Q000737:chemistry / Q000494:pharmacology; D008422:Materials Testing; D014144:Tragacanth / Q000737:chemistry / Q000494:pharmacology; D014439:Tyramine / Q000737:chemistry / Q000494:pharmacology
chemical_list: D020100:Hydrogels; D014144:Tragacanth; D014439:Tyramine
keywords: Biomedical applications; Electron beam irradiation; Gum tragacanth; Hydrogel; Tyramine