title: Dynamics of Erythropoiesis in Erythroblastic Islands in the Bone Marrow in Experimental Benzene-Induced Anemia.
abstract: In 14 days after triple subcutaneous injection of benzene to rats in a dose of 0.05 ml/100 g body weight, the number of erythroblastic islands in the bone marrow 2-fold decreased, de novo erythropoiesis ceased, de repeto erythropoiesis slowed down, and the number of lymphoid cells contacting with erythroblastic islands decreased. By day 56 of the experiment, proliferation of erythroid cells in the bone marrow start to recover due to erythropoiesis reconstitution, but the number of reticulocytes in the blood remained low. Analysis of phagocytic ability of macrophages in the erythroblastic islands showed that the intensity of phagocytosis of latex particles in mature islands decreased, which could affect denucleation of oxyphilic erythroblasts.
authors: South Ural State Medical University, Ministry of Health of the Russian Federation, Chelyabinsk, Russia. natalya-tishevskaya@yandex.ru.
authors: N V
authors: NV
authors: Tishevskaya
authors: South Ural State Medical University, Ministry of Health of the Russian Federation, Chelyabinsk, Russia.
authors: A A
authors: AA
authors: Bolotov
authors: South Ural State Medical University, Ministry of Health of the Russian Federation, Chelyabinsk, Russia.
authors: Ya E
authors: YE
authors: Lebedeva
mesh_terms: D000740:Anemia / Q000139:chemically induced* / Q000378:metabolism*; D000818:Animals; D001554:Benzene / Q000633:toxicity*; D001853:Bone Marrow / Q000187:drug effects / Q000378:metabolism; D004900:Erythroblasts / Q000187:drug effects* / Q000378:metabolism; D004920:Erythropoiesis / Q000187:drug effects* / Q000502:physiology; D005260:Female; D051381:Rats
chemical_list: D001554:Benzene
keywords: benzene; erythroblastic island; erythropoiesis; phagocytosis; reticulocytes