title: HBV-Associated Postinfectious Acute Glomerulonephritis: A Report of 10 Cases.
abstract: Postinfectious acute glomerulonephritis (PIGN) may occur after various bacterial and viral infections. Hepatitis B virus (HBV) infection is a cause of chronic glomerulonephritis. We report here 10 cases (ages 7-20 years-old) of chronic HBV carriers with acute glomerulonephritis, with positive glomerular staining of hepatitis B surface antigen, and detectable presence of HBV DNA in the glomeruli. This form of PIGN, HBV-PIGN, has not been previously identified. To further characterize clinical and pathological features of HBV- PIGN, we selected 10 cases of age-matched non-HBV PIGN for comparison. While both HBV associated PIGN and non-HBV PIGN similarly presented as proteinuria, hematuria, and hypertension, there was a trend of higher acute kidney injury and worsened prognosis in HBV-PIGN. 6 months after the onset, 4 patients with HBV associated PIGN did not show improvement from the disease, whereas all patients with non-HBV PIGN had complete or partial recovery. Pathologically, both HBV associated PIGN and non-HBV PIGN showed typical diffuse glomerular endocapillary proliferation, but HBV associated PIGN differed from classical PIGN with much fewer sub-epithelial glomerular "hump-shape" immune complex depositions. In conclusion, we have identified a novel association of HBV infection with acute glomerulonephritis.
authors: Department of Nephrology and Medicine, Dongfang Hospital, Fujian Medical University, Fuzhou, Fujian, China.
authors: Yong
authors: Y
authors: Zhang
authors: Department of Nephrology and Medicine, Dongfang Hospital, Fujian Medical University, Fuzhou, Fujian, China.
authors: Junxia
authors: J
authors: Li
authors: Department of Nephrology and Medicine, Dongfang Hospital, Fujian Medical University, Fuzhou, Fujian, China.
authors: Weihua
authors: W
authors: Peng
authors: Department of Nephrology and Medicine, Dongfang Hospital, Fujian Medical University, Fuzhou, Fujian, China.
authors: Guoqing
authors: G
authors: Yu
authors: Department of Nephrology and Medicine, Dongfang Hospital, Fujian Medical University, Fuzhou, Fujian, China.
authors: Liping
authors: L
authors: Wang
authors: Department of Nephrology and Medicine, Dongfang Hospital, Fujian Medical University, Fuzhou, Fujian, China.
authors: Jian
authors: J
authors: Chen
authors: Department of Nephrology, The Second Hospital, and Advanced Institute for Medical Sciences, Dalian Medical University, Dalian, China.
authors: Feng
authors: F
authors: Zheng
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D002648:Child; D005260:Female; D005921:Glomerulonephritis / Q000150:complications* / Q000473:pathology; D006509:Hepatitis B / Q000150:complications*; D006801:Humans; D007678:Kidney Glomerulus / Q000473:pathology / Q000648:ultrastructure; D008297:Male