title: Biomimetic coatings enhance tribocorrosion behavior and cell responses of commercially pure titanium surfaces.
abstract: Biofunctionalized surfaces for implants are currently receiving much attention in the health care sector. Our aims were (1) to create bioactive Ti-coatings doped with Ca, P, Si, and Ag produced by microarc oxidation (MAO) to improve the surface properties of biomedical implants, (2) to investigate the TiO2 layer stability under wear and corrosion, and (3) to evaluate human mesenchymal stem cells (hMSCs) responses cultured on the modified surfaces. Tribocorrosion and cell experiments were performed following the MAO treatment. Samples were divided as a function of different Ca/P concentrations and treatment duration. Higher Ca concentration produced larger porous and harder coatings compared to the untreated group (p < 0.001), due to the presence of rutile structure. Free potentials experiments showed lower drops (-0.6 V) and higher coating lifetime during sliding for higher Ca concentration, whereas lower concentrations presented similar drops (-0.8 V) compared to an untreated group wherein the drop occurred immediately after the sliding started. MAO-treated surfaces improved the matrix formation and osteogenic gene expression levels of hMSCs. Higher Ca/P ratios and the addition of Ag nanoparticles into the oxide layer presented better surface properties, tribocorrosive behavior, and cell responses. MAO is a promising technique to enhance the biological, chemical, and mechanical properties of dental implant surfaces.
authors: Department of Prosthodontics and Periodontology, Piracicaba Dental School, University of Campinas (UNICAMP), Av Limeira, 901, Piracicaba, São Paulo 13414-903, Brazil.
authors: Isabella da Silva Vieira
authors: Ida S
authors: Marques
authors: Department of Restorative Dentistry, University of Illinois at Chicago, College of Dentistry, 801 S Paulina, Chicago, Illinois 60612.
authors: Maria Fernanda
authors: MF
authors: Alfaro
authors: Department of Prosthodontics and Periodontology, Piracicaba Dental School, University of Campinas (UNICAMP), Av Limeira, 901, Piracicaba, São Paulo 13414-903, Brazil.
authors: Miki Taketomi
authors: MT
authors: Saito
authors: Laboratory of Technological Plasmas, Engineering College, Univ Estadual Paulista (UNESP), Av Três de Março, 511, Sorocaba, São Paulo 18087-180, Brazil.
authors: Nilson Cristino
authors: NC
authors: da Cruz
authors: Departments of Chemical Engineering and Bioengineering, University of Illinois at Chicago, 851 S. Morgan St., SEO 218, Chicago, Illinois 60607.
authors: Christos
authors: C
authors: Takoudis
authors: Institute of Physics Gleb Wataghin, University of Campinas (UNICAMP), Cidade Universitária Zeferino Vaz, Barão Geraldo, Campinas, São Paulo 13083-859, Brazil.
authors: Richard
authors: R
authors: Landers
authors: Department of Prosthodontics and Periodontology, Piracicaba Dental School, University of Campinas (UNICAMP), Av Limeira, 901, Piracicaba, São Paulo 13414-903, Brazil.
authors: Marcelo Ferraz
authors: MF
authors: Mesquita
authors: Department of Prosthodontics and Periodontology, Piracicaba Dental School, University of Campinas (UNICAMP), Av Limeira, 901, Piracicaba, São Paulo 13414-903, Brazil.
authors: Francisco Humberto
authors: FH
authors: Nociti Junior
authors: Department of Biomedical Sciences, University of Illinois, College of Medicine at Rockford, 1601 Parkview Avenue, Rockford, Illinois 61107.
authors: Mathew T
authors: MT
authors: Mathew
authors: Department of Restorative Dentistry, University of Illinois at Chicago, College of Dentistry, 801 S Paulina, Chicago, Illinois 60612.
authors: Cortino
authors: C
authors: Sukotjo
authors: Department of Prosthodontics and Periodontology, Piracicaba Dental School, University of Campinas (UNICAMP), Av Limeira, 901, Piracicaba, São Paulo 13414-903, Brazil.
authors: Valentim Adelino Ricardo
authors: VA
authors: Barão
mesh_terms: D020099:Coated Materials, Biocompatible; D003343:Corrosion; D006801:Humans; D059630:Mesenchymal Stem Cells / Q000502:physiology; D019736:Prostheses and Implants; D013499:Surface Properties; D014025:Titanium
chemical_list: D020099:Coated Materials, Biocompatible; C009495:titanium dioxide; D014025:Titanium