title: 'Childhood systemic mastocytosis associated with t (8; 21) (q22; q22) acute myeloid leukemia'.
abstract: Systemic mastocytosis (SM) with associated clonal nonmast cell lineage disease is seen in up to 20% cases of SM. SM is uncommon in the pediatric population. T (8; 21) (q22; q22) is a good prognostic factor in acute myeloid leukemia (AML). However, the presence of SM confers poor prognosis in t (8; 21) (q22; q22) associated AML. We report the case of a child with t (8; 21) (q22; q22) associated AML with SM and her minimal residual disease status over the course of her treatment. In our case, the abnormal mast cells, showing co-expression of CD25 and CD2, persisted even after the marrow showed no evidence of residual AML.
authors: Department of Pathology, Hematopathology Laboratory, Tata Memorial Hospital, Mumbai, Maharashtra, India.
authors: Nikhil
authors: N
authors: Rabade
authors: Department of Pathology, Hematopathology Laboratory, Tata Memorial Hospital, Mumbai, Maharashtra, India.
authors: Prashant
authors: P
authors: Tembhare
authors: Department of Pathology, Hematopathology Laboratory, Tata Memorial Hospital, Mumbai, Maharashtra, India.
authors: Nikhil
authors: N
authors: Patkar
authors: Department of Cancer Cytogenetics, Tata Memorial Hospital, Mumbai, Maharashtra, India.
authors: Pratibha
authors: P
authors: Amare
authors: Department of Pediatric Oncology, Tata Memorial Hospital, Mumbai, Maharashtra, India.
authors: Brijesh
authors: B
authors: Arora
authors: Department of Pathology, Hematopathology Laboratory, Tata Memorial Hospital, Mumbai, Maharashtra, India.
authors: P G
authors: PG
authors: Subramanian
authors: Department of Pathology, Hematopathology Laboratory, Tata Memorial Hospital, Mumbai, Maharashtra, India.
authors: Sumeet
authors: S
authors: Gujral
mesh_terms: D001853:Bone Marrow / Q000473:pathology; D018801:CD2 Antigens / Q000032:analysis; D002648:Child; D005260:Female; D006801:Humans; D053645:Interleukin-2 Receptor alpha Subunit / Q000032:analysis; D015470:Leukemia, Myeloid, Acute / Q000150:complications* / Q000175:diagnosis*; D008407:Mast Cells / Q000737:chemistry; D034721:Mastocytosis, Systemic / Q000150:complications* / Q000175:diagnosis*; D014178:Translocation, Genetic
chemical_list: D018801:CD2 Antigens; C508017:IL2RA protein, human; D053645:Interleukin-2 Receptor alpha Subunit