title: The estrogen-related receptors (ERRs): potential targets against bone loss.
abstract: Bone loss and the resulting skeletal fragility is induced by several pathological or natural conditions, the most prominent of which being aging as well as the decreased levels of circulating estrogens in post-menopause females. To date, most treatments against bone loss aim at preventing excess bone resorption. We here summarize data indicating that the estrogen-related receptors (ERRs) α and γ prevent bone formation. Inhibiting these receptors may thus constitute an anabolic approach by increasing bone formation.
authors: Institut de Génomique Fonctionnelle de Lyon, CNRS UMR5242, Université de Lyon, Université Lyon I, Ecole Normale Supérieure de Lyon, Lyon, France.|Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences, School of Life Sciences, East China Normal University, Shanghai, 200241, China.
authors: Ling
authors: L
authors: Zhang
authors: Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences, School of Life Sciences, East China Normal University, Shanghai, 200241, China.
authors: Jiemin
authors: J
authors: Wong
authors: Institut de Génomique Fonctionnelle de Lyon, CNRS UMR5242, Université de Lyon, Université Lyon I, Ecole Normale Supérieure de Lyon, Lyon, France. jean-marc.vanacker@ens-lyon.fr.
authors: Jean-Marc
authors: JM
authors: Vanacker
mesh_terms: D000818:Animals; D001862:Bone Resorption / Q000188:drug therapy* / Q000503:physiopathology; D002113:Calcification, Physiologic; D006801:Humans; D008024:Ligands; D008954:Models, Biological; D058990:Molecular Targeted Therapy; D011960:Receptors, Estrogen / Q000378:metabolism*
chemical_list: D008024:Ligands; D011960:Receptors, Estrogen
keywords: Bone; ERR; Menopause; Nuclear receptors; Osteoblasts