title: Femoral Bone Mineral Density, Neck-Shaft Angle and Mean Femoral Neck Width as Predictors of Hip Fracture in Men and Women.
abstract: The effect of femoral bone mineral density (BMD) and several parameters of femoral neck geometry (hip axis length, neck-shaft angle and mean femoral neck width) on hip fracture risk in a Spanish population was assessed in a cross-sectional study. All parameters were determined by dual-energy X-ray absorptiometry. There were 411 patients (116 men, 295 women; aged 60-90 years) with hip fractures in whom measurements were taken in the contralateral hip. Controls were 545 persons (235 men, 310 women; aged 60-90 years) who participated in a previous study on BMD in a healthy Spanish population. Femoral neck BMD was significantly lower, and neck-shaft angle and mean femoral neck width significantly higher, in fracture cases than in controls. The logistic regression analysis adjusted by age, height and weight showed that a decrease of 1 standard deviation (SD) in femoral neck BMD was associated with an odds ratio of hip fracture of 4.52 [95% confidence interval (CI) 2.93 to 6.96] in men and 4.45 (95% CI 3.11 to 6.36) in women; an increase of 1 SD in neck-shaft angle of 2.45 (95% CI 1.73 to 3.45) in men and 3.48 (95% CI 2.61 to 4.65) in women; and an increase of 1 SD in mean femoral neck width of 2.15 (95% CI 1.55 to 2.98) in men and 2.40 (95% CI 1.79 to 3.22) in women. The use of a combination of femoral BMD and geometric parameters of the femoral neck except for hip axis length may improve hip fracture risk prediction allowing a better therapeutic strategy for hip fracture prevention.
authors: Servicio de Metabolismo Óseo y Mineral, Instituto Reivia Sofía de Investigacion, Hospital Central de Asturias, Oviedo, , , , , , ES.
authors: C
authors: C
authors: Gómez Alonso
authors: Unidad Metabólica, Fundación Jiménez Díaz, Madrid, , , , , , ES.
authors: M
authors: M
authors: Díaz Curiel
authors: Departamento de Endocrinología, Hospital Doce de Octubre, Madrid, , , , , , ES.
authors: F
authors: F
authors: Hawkins Carranza
authors: Departamento de Medicina Interna, Hospital Virgen de la Macarena, Sevilla;, , , , , , ES.
authors: R
authors: R
authors: Pérez Cano
authors: A
authors: A
authors: Díez Pérez
keywords: Key words: Accidental falls – Densitometry, X-ray – Femur neck – Fractures, prevention and control – Hip fractures – Osteoporosis, complications