title: Measuring local immunoglobulin E in the inferior turbinate nasal mucosa in patients with allergic rhinitis.
abstract: BACKGROUND
  Studies show that immunoglobulin E (IgE) is produced in the local nasal mucosa in allergic rhinitis patients. However, no study involved the measurement of IgE levels in the local nasal mucosal tissue in allergic rhinitis patients. This study aimed to measure the local IgE levels in the nasal mucosal tissue and to compare the levels of total IgE and specific IgEs in the serum and the inferior turbinate nasal mucosa in allergic rhinitis patients using the AlaSTAT 3gAllergy assay (Siemens Healthcare Diagnostics AG, Erlangen, Germany).
  
  
  METHODS
  Total IgE antibodies and allergen-specific IgE antibodies in each sample of nasal mucosal tissue from 11 allergic rhinitis patients were measured with the AlaSTAT 3gAllergy assay. We compared the levels of total IgE and IgEs specific for house dust (HD), mites, and cedar pollen in the serum and the inferior turbinate.
  
  
  RESULTS
  The total IgE levels and the cedar pollen-specific IgE levels in the inferior turbinate mucosal tissue correlated significantly with their respective levels in serum. The HD- and mite-specific IgE levels in the inferior turbinate mucosal tissue did not correlate significantly with their respective levels in the serum.
  
  
  CONCLUSIONS
  Our results evaluating the correlations between nasal mucosal and serum levels of antigen-specific IgE indicate that IgE produced in the nasal mucosa affects the IgE levels in the serum, especially the cedar pollen-specific IgE.
authors: Department of Otorhinolaryngology, Toho University Sakura Medical Center, Chiba, Japan. Electronic address: yasushiota5610@yahoo.co.jp.
authors: Yasushi
authors: Y
authors: Ota
authors: Department of Otorhinolaryngology, Toho University Sakura Medical Center, Chiba, Japan.
authors: Yoshihiro
authors: Y
authors: Ikemiyagi
authors: Department of Clinical Laboratory, Toho University Sakura Medical Center, Chiba, Japan.
authors: Toshiya
authors: T
authors: Sato
authors: CAI Business Unit, Siemens Healthcare Diagnostics K.K., Tokyo, Japan.
authors: Tatsuo
authors: T
authors: Funakoshi
authors: Department of Pathology, Toho University Sakura Medical Center, Chiba, Japan.
authors: Nobuyuki
authors: N
authors: Hiruta
authors: Department of Pathology, Toho University Sakura Medical Center, Chiba, Japan.
authors: Makoto
authors: M
authors: Kitamura
authors: Department of Clinical Laboratory, Toho University Sakura Medical Center, Chiba, Japan.
authors: Hideaki
authors: H
authors: Bujo
authors: Department of Otorhinolaryngology, Toho University Sakura Medical Center, Chiba, Japan.
authors: Mitsuya
authors: M
authors: Suzuki
mesh_terms: D000485:Allergens / Q000276:immunology; D000818:Animals; D000918:Antibody Specificity / Q000276:immunology; D015415:Biomarkers; D004804:Eosinophils / Q000276:immunology / Q000502:physiology; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood / Q000276:immunology*; D007958:Leukocyte Count; D009297:Nasal Mucosa / Q000276:immunology*; D065631:Rhinitis, Allergic / Q000175:diagnosis* / Q000276:immunology*; D014420:Turbinates
chemical_list: D000485:Allergens; D015415:Biomarkers; D007073:Immunoglobulin E
keywords: AlaSTAT 3gAllergy assay; Cedar pollen; House dust; Local allergic rhinitis; Mites