title: Escorted by chaperones: Sti1 helps to usher precursor proteins from the ribosome to mitochondria.
abstract: Little is known about factors that interact with mitochondrial precursor proteins in the cytosol. Employing site-specific crosslinking this study identifies chaperones of the Hsp70 and Hsp90 families as well as Sti1 as escorts of cytosolic preproteins. Sti1 presumably helps to hand-over preproteins from Hsp70 to the Hsp90 system and thereby facilitates their binding to TOM receptors on the mitochondrial surface.
authors: Cell Biology, University of Kaiserslautern, Germany.
authors: Katja G
authors: KG
authors: Hansen
authors: Cell Biology, University of Kaiserslautern, Germany.
authors: Anna
authors: A
authors: Schlagowski
authors: Cell Biology, University of Kaiserslautern, Germany.
authors: Johannes M
authors: JM
authors: Herrmann
mesh_terms: D018841:HSP90 Heat-Shock Proteins; D006801:Humans; D008928:Mitochondria; D018832:Molecular Chaperones; D011485:Protein Binding; D012270:Ribosomes
chemical_list: D018841:HSP90 Heat-Shock Proteins; D018832:Molecular Chaperones