title: Relationship of retinal vascular caliber variation with intracranial arterial stenosis.
abstract: To investigate the associations of retinal vessel parameters with intracranial arterial stenosis (ICAS) assessed by Transcranial Doppler ultrasonography.
  
  
  
  Data on transcranial Doppler ultrasonography and quantitative retinal vessel parameters from 627 participants in a health screening program were included in this study. ICAS was defined as >50% intracranial arterial stenosis (ICAS) based on criteria modified from the stroke outcomes and neuroimaging of intracranial atherosclerosis (SONIA) trial assessed by transcranial Doppler (TCD) ultrasonography. A semi-automated computer-assisted program (Singapore I Vessel Assessment) was used to measure the retinal vascular parameters from the photographs. Multivariate analysis was performed to identify which retinal vessel parameters were associated with increased risk of ICAS.
  
  
  
  Among 627 participants, 24 (3.8%) had ICAS diagnosed by TCD. Subjects with ICAS had eyes with wider mean central retinal artery equivalent (CRAE) and central retinal vein equivalent (CRVE) in comparison to subjects without ICAS. Men (odds ratio [OR]:13.1, 95% confidence interval: 3.13-33.33) and a large standard deviation of mean arterial width (STDWa) were associated with ICAS (first vs. third tertile: OR ratio: 14.04, 95% confidence interval: 1.71-115.32; first vs. third tertile: OR ratio: 22.1, 95% confidence interval: 2.56-190.97) after adjusting for possible confounders.
  
  
  
  A large variation in retinal arteriolar diameter is associated with ICAS. This study suggests the possible relationship between retina vessel and early changes within the cerebrovascular network.
authors: Department of Endocrinology and Metabolism, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
authors: Eun-Jung
authors: EJ
authors: Rhee
authors: Departments of Neurology Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
authors: Pil-Wook
authors: PW
authors: Chung
authors: Singapore Eye Research Institute, Singapore National Eye Center, Duke-NUS Medical School National University of Singapore, Singapore.
authors: Tien Y
authors: TY
authors: Wong
authors: Department of Ophthalmology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea. Electronic address: eye-su@hanmail.net.
authors: Su Jeong
authors: SJ
authors: Song
mesh_terms: D000328:Adult; D001157:Arterial Occlusive Diseases / Q000000981:diagnostic imaging / Q000473:pathology*; D058070:Asymptomatic Diseases; D016022:Case-Control Studies; D002536:Cerebral Arteries / Q000000981:diagnostic imaging; D016009:Chi-Square Distribution; D003251:Constriction, Pathologic; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D002537:Intracranial Arteriosclerosis / Q000000981:diagnostic imaging / Q000473:pathology*; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D016017:Odds Ratio; D010781:Photography; D011237:Predictive Value of Tests; D012161:Retinal Artery / Q000473:pathology*; D012169:Retinal Vein / Q000473:pathology*; D012307:Risk Factors; D012720:Severity of Illness Index; D017585:Ultrasonography, Doppler, Transcranial
keywords: Intracranial arterial stenosis; Retinal vessel; Transcranial doppler