title: Intimal Sarcoma of the Pulmonary Artery Treated with Pazopanib.
abstract: Intimal sarcoma is a rare disease with a poor prognosis. We herein report the case of a 71-year-old man with intimal sarcoma of the pulmonary artery treated with pazopanib. The tumor showed regression after 1 month of treatment. Hand-foot syndrome led to cessation of pazopanib, which triggered a disease flare. Pazopanib should be considered in patients with intimal sarcoma of the pulmonary artery that is unresectable or recurrent after surgery or cytotoxic chemotherapy. We must be careful about drug cessation, as it can lead to a disease flare.
authors: Respiratory Medicine, National Hospital Organization Tokyo Medical Center, Japan.
authors: Yohei
authors: Y
authors: Funatsu
authors: Miwa
authors: M
authors: Hirayama
authors: Junichi
authors: J
authors: Shiraishi
authors: Takanori
authors: T
authors: Asakura
authors: Misa
authors: M
authors: Wakaki
authors: Erina
authors: E
authors: Yamada
authors: Kazuyuki
authors: K
authors: Fujimoto
authors: Ryosuke
authors: R
authors: Satomi
authors: Shunsuke
authors: S
authors: Inaki
authors: Yuya
authors: Y
authors: Murata
authors: Yoshitaka
authors: Y
authors: Oyamada
mesh_terms: D000368:Aged; D020533:Angiogenesis Inhibitors / Q000009:adverse effects / Q000627:therapeutic use*; D060831:Hand-Foot Syndrome / Q000209:etiology; D006801:Humans; D007191:Indazoles; D008297:Male; D011651:Pulmonary Artery / Q000473:pathology*; D011743:Pyrimidines / Q000009:adverse effects / Q000627:therapeutic use*; D013449:Sulfonamides / Q000009:adverse effects / Q000627:therapeutic use*; D017539:Tunica Intima / Q000473:pathology*; D019043:Vascular Neoplasms / Q000188:drug therapy* / Q000473:pathology*
chemical_list: D020533:Angiogenesis Inhibitors; D007191:Indazoles; D011743:Pyrimidines; D013449:Sulfonamides; C516667:pazopanib