title: PRODIGY: a web server for predicting the binding affinity of protein-protein complexes.
abstract: Gaining insights into the structural determinants of protein-protein interactions holds the key for a deeper understanding of biological functions, diseases and development of therapeutics. An important aspect of this is the ability to accurately predict the binding strength for a given protein-protein complex. Here we present PROtein binDIng enerGY prediction (PRODIGY), a web server to predict the binding affinity of protein-protein complexes from their 3D structure. The PRODIGY server implements our simple but highly effective predictive model based on intermolecular contacts and properties derived from non-interface surface.
  
  
  
  PRODIGY is freely available at: http://milou.science.uu.nl/services/PRODIGY CONTACT: a.m.j.j.bonvin@uu.nl, a.vangone@uu.nl.
authors: Computational Structural Biology Group, Bijvoet Center for Biomolecular Research, Faculty of Science - Department of Chemistry, Utrecht University, 3584CH Utrecht, The Netherlands.
authors: Li C
authors: LC
authors: Xue
authors: Computational Structural Biology Group, Bijvoet Center for Biomolecular Research, Faculty of Science - Department of Chemistry, Utrecht University, 3584CH Utrecht, The Netherlands.
authors: João Pglm
authors: JP
authors: Rodrigues
authors: Computational Structural Biology Group, Bijvoet Center for Biomolecular Research, Faculty of Science - Department of Chemistry, Utrecht University, 3584CH Utrecht, The Netherlands.
authors: Panagiotis L
authors: PL
authors: Kastritis
authors: Computational Structural Biology Group, Bijvoet Center for Biomolecular Research, Faculty of Science - Department of Chemistry, Utrecht University, 3584CH Utrecht, The Netherlands.
authors: Alexandre Mjj
authors: AM
authors: Bonvin
authors: Computational Structural Biology Group, Bijvoet Center for Biomolecular Research, Faculty of Science - Department of Chemistry, Utrecht University, 3584CH Utrecht, The Netherlands.
authors: Anna
authors: A
authors: Vangone
mesh_terms: D019295:Computational Biology / Q000379:methods*; D020407:Internet; D011485:Protein Binding; D011487:Protein Conformation; D025941:Protein Interaction Mapping / Q000379:methods*; D012984:Software