title: Pd Nanoparticles Decorated N-Doped Graphene Quantum Dots@N-Doped Carbon Hollow Nanospheres with High Electrochemical Sensing Performance in Cancer Detection.
abstract: The development of carbon based hollow-structured nanospheres (HNSs) materials has stimulated growing interest due to their controllable structure, high specific surface area, large void space, enhanced mass transport, and good biocompatibility. The incorporation of functional nanomaterials into their core and/or shell opens new horizons in designing functionalized HNSs for a wider spectrum of promising applications. In this work, we report a new type of functionalized HNSs based on Pd nanoparticles (NPs) decorated double shell structured N-doped graphene quantum dots (NGQDs)@N-doped carbon (NC) HNSs, with ultrafine Pd NPs and "nanozyme" NGQDs as dual signal-amplifying nanoprobes, and explore their promising application as a highly efficient electrocatalyst in electrochemical sensing of a newly emerging biomarker, i.e., hydrogen peroxide (H2O2), for cancer detection. Due to the synergistic effect of the robust and conductive HNS supports and catalytically active Pd NPs and NGQD in facilitating electron transfer, the NGQD@NC@Pd HNS hybrid material exhibits high electrocatalytic activity toward the direct reduction of H2O2 and can promote the electrochemical reduction reaction of H2O2 at a favorable potential of 0 V, which effectively restrains the redox of most electroactive species in physiological samples and eliminates interference signals. The resultant electrochemical H2O2 biosensor based hybrid HNSs materials demonstrates attractive performance, including low detection limit down to nanomole level, short response time within 2 s, as well as high sensitivity, reproducibility, selectivity, and stability, and have been used in real-time tracking of trace amounts of H2O2 secreted from different living cancer cells in a normal state and treated with chemotherapy and radiotherapy.
authors: School of Chemistry and Environmental Engineering, Wuhan Institute of Technology , Wuhan, 430073, China.
authors: Jiangbo
authors: J
authors: Xi
authors: Chuyi
authors: C
authors: Xie
authors: Yan
authors: Y
authors: Zhang
authors: Lu
authors: L
authors: Wang
authors: Jian
authors: J
authors: Xiao
authors: Xianming
authors: X
authors: Duan
authors: Union Hospital, Tongji Medical College, Huazhong University of Science and Technology , Wuhan, 430022, P. R. China.
authors: Jinghua
authors: J
authors: Ren
authors: Fei
authors: F
authors: Xiao
authors: Shuai
authors: S
authors: Wang
keywords: Pd nanoparticles; cancer detection; carbon hollow nanospheres; electrocatalyst; electrochemical biosensor; graphene quantum dots