title: The complex cascade of cellular events governing inflammasome activation and IL-1β processing in response to inhaled particles.
abstract: The innate immune system is the first line of defense against inhaled particles. Macrophages serve important roles in particle clearance and inflammatory reactions. Following recognition and internalization by phagocytes, particles are taken up in vesicular phagolysosomes. Intracellular phagosomal leakage, redox unbalance and ionic movements induced by toxic particles result in pro-IL-1β expression, inflammasome complex engagement, caspase-1 activation, pro-IL-1β cleavage, biologically-active IL-1β release and finally inflammatory cell death termed pyroptosis. In this review, we summarize the emerging signals and pathways involved in the expression, maturation and secretion of IL-1β during these responses to particles. We also highlight physicochemical characteristics of particles (size, surface and shape) which determine their capacity to induce inflammasome activation and IL-1β processing.
authors: Louvain Centre for Toxicology and Applied Pharmacology (LTAP), Institut de Recherche Expérimentale et Clinique (IREC), Université catholique de Louvain, Avenue Mounier 52, B1.52-12, 1200, Brussels, Belgium.
authors: Virginie
authors: V
authors: Rabolli
authors: Louvain Centre for Toxicology and Applied Pharmacology (LTAP), Institut de Recherche Expérimentale et Clinique (IREC), Université catholique de Louvain, Avenue Mounier 52, B1.52-12, 1200, Brussels, Belgium.
authors: Dominique
authors: D
authors: Lison
authors: Louvain Centre for Toxicology and Applied Pharmacology (LTAP), Institut de Recherche Expérimentale et Clinique (IREC), Université catholique de Louvain, Avenue Mounier 52, B1.52-12, 1200, Brussels, Belgium. francois.huaux@uclouvain.be.
authors: François
authors: F
authors: Huaux
mesh_terms: D000818:Animals; D006801:Humans; D007113:Immunity, Innate; D058847:Inflammasomes / Q000378:metabolism*; D019570:Inhalation Exposure; D053583:Interleukin-1beta / Q000378:metabolism*; D008264:Macrophages / Q000276:immunology
chemical_list: D058847:Inflammasomes; D053583:Interleukin-1beta
keywords: Alarmins; Cytokines; IL-1 family; Inflammasome; Inflammation; Macrophages; Nanoparticles; Silica