title: Decarboxylative Annulation of α-Amino Acids with γ-Nitroaldehydes.
abstract: Indolizidine and quinolizidine derivatives are readily assembled from proline or pipecolic acid and γ-nitroaldehydes by means of a decarboxylative annulation process. These reactions are promoted by simple acetic acid and involve azomethine ylides as reactive intermediates. The method was applied to the synthesis of an epiquinamide analog.
authors: Department of Chemistry and Chemical Biology, Rutgers, The State University of New Jersey , Piscataway, New Jersey 08854, United States.
authors: YoungKu
authors: Y
authors: Kang
authors: Department of Chemistry and Chemical Biology, Rutgers, The State University of New Jersey , Piscataway, New Jersey 08854, United States.
authors: Daniel
authors: D
authors: Seidel
mesh_terms: D000447:Aldehydes / Q000737:chemistry*; D000596:Amino Acids / Q000737:chemistry*; D003653:Decarboxylation; D015394:Molecular Structure; D009574:Nitro Compounds / Q000737:chemistry*; D011807:Quinolizines / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D000447:Aldehydes; D000596:Amino Acids; D009574:Nitro Compounds; D011807:Quinolizines; C481035:epiquinamide