title: Down-regulation of AQP4 Inhibits Proliferation, Migration and Invasion of Human Breast Cancer Cells.
abstract: Aquaporins (AQPs), proteinaceous water channels, have been proposed as mediators of tumour development and progression. However, the role of aquaporin 4 (AQP4), a member of the AQP family, in breast cancer has not been distinctly evaluated. The aim of the present study was to examine the effect of AQP4 down-regulation on proliferation, migration and invasion in human breast cancer. To determine this effect, siRNA interference was used to knock down its expression in T47D and MCF-7 cell lines. Down-regulation of AQP4 resulted in increased expression of E-cadherin along with an inhibitory effect on the proliferation, migration and invasion in breast cancer cells. In addition, AQP4 regulation of cell proliferation could be related with the ERK/Ecadherin pathway. In conclusion, the present data have suggested that down-regulation of AQP4 inhibits breast cancer cell proliferation, migration and invasion.
authors: Renmin Hospital of Wuhan University, Wuhan, China.
authors: Y-B
authors: YB
authors: Li
authors: Renmin Hospital of Wuhan University, Wuhan, China.
authors: S-R
authors: SR
authors: Sun
authors: Inner Mongolia People's Hospital, Hohhot, China.
authors: X-H
authors: XH
authors: Han
mesh_terms: D051401:Aquaporin 4 / Q000235:genetics* / Q000378:metabolism*; D015153:Blotting, Western; D001943:Breast Neoplasms / Q000503:physiopathology; D002465:Cell Movement / Q000235:genetics; D049109:Cell Proliferation / Q000235:genetics; D015536:Down-Regulation; D005260:Female; D006801:Humans; D061986:MCF-7 Cells; D009361:Neoplasm Invasiveness / Q000235:genetics; D034622:RNA Interference; D034741:RNA, Small Interfering / Q000378:metabolism
chemical_list: D051401:Aquaporin 4; D034741:RNA, Small Interfering