title: Type I insulin-like growth factor as a liver reserve assessment tool in hepatocellular carcinoma.
abstract: Chronic liver diseases (CLDs) encompass a wide range of illnesses, including nonalcoholic fatty liver disease, nonalcoholic steatohepatitis, and viral hepatitis. Deterioration of liver capacity, with subsequent progression into cirrhosis and hepatocellular carcinoma (HCC), ultimately leads to a further decrease in the hepatic reserve. The Child-Turcotte-Pugh scoring system is the standard tool for assessing underlying liver reserve capacity in routine practice and in clinical trials of CLD and HCC. In this review, we highlight the clinical significance of insulin-like growth factor-I (IGF-I) and the growth hormone (GH) signaling pathway in HCC. IGF-I could be a marker for liver reserve capacity in CLDs and HCC in clinical practice. This approach could improve the risk assessment and stratifications of patients on the basis of their underlying liver reserve, either before active treatment in routine practice or before they are enrolled in clinical trials.
authors: Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA; Department of Clinical Oncology, Assiut University Hospital, Assiut, Egypt.
authors: Reham
authors: R
authors: Abdel-Wahab
authors: Department of Clinical Oncology, Assiut University Hospital, Assiut, Egypt.
authors: Samir
authors: S
authors: Shehata
authors: Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
authors: Manal M
authors: MM
authors: Hassan
authors: Department of Endocrinology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
authors: Mouhammed A
authors: MA
authors: Habra
authors: Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
authors: Ghazaleh
authors: G
authors: Eskandari
authors: Department of Veterinary Medicine and Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
authors: Peggy T
authors: PT
authors: Tinkey
authors: Department of Veterinary Medicine and Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
authors: Jennifer
authors: J
authors: Mitchell
authors: Department of Systems Biology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
authors: Ju-Seog
authors: JS
authors: Lee
authors: Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA; Graduate School of Biomedical Sciences, Houston, TX, USA.
authors: Hesham M
authors: HM
authors: Amin
authors: Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
authors: Ahmed O
authors: AO
authors: Kaseb
keywords: IGF-I; chronic liver disease; growth hormone