title: Alveolar-filling growth pattern of sarcomatoid malignant pleural mesothelioma.
abstract: A case of sarcomatoid malignant pleural mesothelioma showing extremely rare growth pattern is described. A 63-year-old man presented to our hospital with left pleural effusion. A computed tomography (CT) scan of the chest showed diffusely thickened left visceral and parietal pleura associated with intermingled pulmonary infiltrative shadowing. Biopsy of the pleura under general anaesthesia confirmed the diagnosis of sarcomatoid malignant pleural mesothelioma. The patient underwent left extra-pleural pneumonectomy. Histopathologically, the sarcomatoid spindle tumour cells changed their morphology to polygonal cells in the pulmonary parenchyma and grew upwards, filling the alveolar space without the destruction of its septa, showing an alveolar-filling growth pattern. The current report indicates a case of sarcomatoid pleural mesothelioma that shows an alveolar-filling growth pattern, despite having not been thoroughly categorized in the World Health Organization (WHO) classification.
authors: Department of Thoracic Surgery Fujieda Municipal General Hospital Fujieda Shizuoka Japan.
authors: Takamitsu
authors: T
authors: Hayakawa
authors: Department of Pathology, Graduate School of Medicine University of Tokyo Tokyo Japan.
authors: Shogo
authors: S
authors: Tajima
authors: Department of Thoracic Surgery Fujieda Municipal General Hospital Fujieda Shizuoka Japan.
authors: Yusuke
authors: Y
authors: Takanashi
authors: Department of Thoracic Surgery Fujieda Municipal General Hospital Fujieda Shizuoka Japan.
authors: Tsuyoshi
authors: T
authors: Takahashi
authors: Department of Thoracic Surgery Fujieda Municipal General Hospital Fujieda Shizuoka Japan.
authors: Hiroshi
authors: H
authors: Neyatani
authors: Department of Surgery Hamamatsu University School of Medicine Hamamatsu Shizuoka Japan.
authors: Kazuhito
authors: K
authors: Funai
keywords: Alveolar‐filling growth pattern; epithelial membrane antigen; sarcomatoid malignant pleural mesothelioma