title: Gastrointestinal Bleeding During the Index Hospitalization for Mechanical Circulatory Support Devices Implantation, a Nationwide Perspective.
abstract: Gastrointestinal bleeding (GIB) is a common adverse event after mechanical circulatory support device implantation. However, the majority of the reported data were obtained from small single-center studies. Our aim was to study the prevalence and predictors of GIB during the index hospitalization of mechanical circulatory support devices implantation using a nationwide database.
  
  
  
  Nationwide inpatient sample (2009-2011) was used to perform a retrospective cross-sectional study. Adult patients with discharge diagnosis codes of congestive heart failure and procedure codes of left-ventricular assist device (LVAD) or intra-aortic balloon pump (IABP) implantation or orthotopic heart transplant (OHT, reference group) were identified. Our outcome was GIB during the index hospitalization when the device was implanted. Predictors that achieved statistical significance on the univariate analysis were included in a multivariable logistic-regression analysis.
  
  
  
  A total of 87,462 patients were included, 87 % of the patients received an IABP, 6 % received LVAD, and 5 % underwent OHT. Prevalence of GIB was 8, 5, and 3 % among those who had LVAD, IABP implantation, and OHT recipients, respectively (p < 0.001). Patients who underwent LVAD implantation had twofold increase in the prevalence of GIB (OR 2.1, 1.7-2.5, p < 0.001) when using IABP or OHT groups as a reference. This increase in the prevalence was not demonstrated among IABP recipients on a multivariate level.
  
  
  
  Prevalence of GIB was higher among LVAD compared to OHT and IABP recipients and could occur as early as the index admission of the device implantation.
authors: Department of Medicine, University of Florida, PO Box 100277, Gainesville, FL, 32610, USA.
authors: Ali
authors: A
authors: Abbas
authors: Department of Medicine, University of Florida, PO Box 100277, Gainesville, FL, 32610, USA.
authors: Ahmed
authors: A
authors: Mahmoud
authors: Division of Cardiovascular Medicine, University of Florida, PO Box 100277, Gainesville, FL, 32610, USA.
authors: Mustafa
authors: M
authors: Ahmed
authors: Division of Cardiovascular Medicine, University of Florida, PO Box 100277, Gainesville, FL, 32610, USA.
authors: Juan
authors: J
authors: Aranda
authors: Division of Thoracic and Cardiovascular Surgery, University of Florida, PO Box 100129, Gainesville, FL, 32610, USA.
authors: Charles T
authors: CT
authors: Klodell
authors: Division of Gastroenterology, Hepatology, and Nutrition, University of Florida College of Medicine, 1600 SW Archer Rd, Box 100214, Gainesville, FL, 32610, USA. Peter.Draganov@medicine.ufl.edu.
authors: Peter V
authors: PV
authors: Draganov
mesh_terms: D000368:Aged; D000925:Anticoagulants / Q000009:adverse effects; D003430:Cross-Sectional Studies; D016208:Databases, Factual; D005260:Female; D006471:Gastrointestinal Hemorrhage / Q000139:chemically induced / Q000453:epidemiology*; D006333:Heart Failure / Q000628:therapy*; D016027:Heart Transplantation; D006353:Heart-Assist Devices; D006760:Hospitalization; D006801:Humans; D007423:Intra-Aortic Balloon Pumping; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D011183:Postoperative Complications / Q000139:chemically induced / Q000453:epidemiology*; D015995:Prevalence; D019919:Prosthesis Implantation; D012189:Retrospective Studies; D012307:Risk Factors; D014481:United States
chemical_list: D000925:Anticoagulants
keywords: Gastrointestinal bleeding; Intra-aortic balloon pump; Left-ventricular assist device; Orthotopic heart transplant