title: Second primary malignancies among patients with myeloma-related-diseases in the KMF database.
abstract: The incidence of second primary malignancies (SPMs) in Japanese patients with myeloma or myeloma-related diseases was studied by using the Kansai Myeloma Forum (KMF) database registered from November 2012 to March 2015. We studied 1,571 cases. Hematologic malignancies were documented in 10 patients, and solid tumors in 36 during this period. The cumulative 5-year incidence was estimated to be 1.0% for hematological malignancies and 3.7% for solid tumors. In the patients with smoldering myeloma or MGUS without treatment, solid tumors but not hematologic malignancies developed, though the cumulative incidence of each malignancy did not differ significantly from that in patients receiving treatment. Although statistical analysis showed that treatment with melphalan, bortezomib, lenalidomide, or thalidomide had no effect on the occurrence of hematological malignancies, lenalidomide administration was more frequent in the patients with solid tumors. To evaluate the SPMs in myeloma or myeloma-related diseases more accurately, accumulation of a larger number of patients and longer observation are needed.
authors: Department of Internal Medicine (hematology), Toyonaka Municipal Hospital.
authors: Satoru
authors: S
authors: Kosugi
authors: Hirohiko
authors: H
authors: Shibayama
authors: Eiji
authors: E
authors: Nakatani
authors: Toru
authors: T
authors: Kida
authors: Kensuke
authors: K
authors: Ohta
authors: Hidemi
authors: H
authors: Kaneko
authors: Hideo
authors: H
authors: Yagi
authors: Hirokazu
authors: H
authors: Tanaka
authors: Shin-Ichi
authors: S
authors: Fuchida
authors: Aya
authors: A
authors: Nakaya
authors: Masayuki
authors: M
authors: Kobayashi
authors: Junya
authors: J
authors: Kuroda
authors: Yuri
authors: Y
authors: Kamitsuji
authors: Nobuhiko
authors: N
authors: Uoshima
authors: Yoko
authors: Y
authors: Adachi
authors: Mitsuru
authors: M
authors: Tsudo
authors: Chihiro
authors: C
authors: Shimazaki
authors: Shosaku
authors: S
authors: Nomura
authors: Masayuki
authors: M
authors: Hino
authors: Itaru
authors: I
authors: Matsumura
authors: Masashi
authors: M
authors: Taniwaki
authors: Yuzuru
authors: Y
authors: Kanakura
authors: Akifumi
authors: A
authors: Takaori-Kondo
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D016208:Databases, Factual; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000628:therapy; D016609:Neoplasms, Second Primary; D055815:Young Adult