title: Validation of the Lupus Impact Tracker in an Australian patient cohort.
abstract: OBJECTIVE
  The objective of this article is to validate the Lupus Impact Tracker (LIT), a disease-specific patient-reported outcome (PRO) tool, in systemic lupus erythematosus (SLE) patients in a multi-ethnic Australian cohort.
  
  
  METHODS
  Patients attending the Monash Lupus Clinic were asked to complete the LIT, a 10-item PRO. Psychometric testing assessing criterion validity, construct validity, test-retest reliability (TRT) and internal consistency reliability (ICR) were performed. We compared the LIT scores across patient characteristics, and correlations between LIT scores and SLEDAI-2k, PGA, and SLICC-SDI were examined.
  
  
  RESULTS
  LIT data were obtained from 73 patients. Patients were 84% female with a median age of 41 years, and 34% were Asian. The cohort had mild-moderate disease activity with a median (IQR) Systemic Lupus Erythematosus Disease Activity Index-2000 (SLEDAI-2k) of 4 (IQR 2-6). The median LIT score was 32.5 (IQR 17.5-50). LIT demonstrated criterion validity against SLEDAI-2k and SDI. Construct validity assessed by confirmatory factor analysis demonstrated an excellent fit (Goodness of fit index 0.95, Comparative Fit Index 1, Root Mean Square Error of Approximation <0.0001). The LIT demonstrated TRT with an overall intraclass correlation coefficient of 0.986 (95% CI 0.968-0.995). ICR was demonstrated with a Cronbach's alpha of 0.838. Patients with disability, low socioeconomic status, or higher disease activity had significantly worse LIT scores.
  
  
  CONCLUSIONS
  The LIT demonstrated properties consistent with its being valid in this population. Lower socioeconomic status appears to have a significant impact on patient-reported health-related quality of life in SLE.
authors: School of Clinical Sciences at Monash Health, Monash University, Melbourne, Victoria, Australia.
authors: A
authors: A
authors: Antony
authors: School of Clinical Sciences at Monash Health, Monash University, Melbourne, Victoria, Australia.
authors: R K
authors: RK
authors: Kandane-Rathnayake
authors: School of Clinical Sciences at Monash Health, Monash University, Melbourne, Victoria, Australia.
authors: T
authors: T
authors: Ko
authors: School of Clinical Sciences at Monash Health, Monash University, Melbourne, Victoria, Australia.
authors: D
authors: D
authors: Boulos
authors: School of Clinical Sciences at Monash Health, Monash University, Melbourne, Victoria, Australia.
authors: A Y
authors: AY
authors: Hoi
authors: Rush University Medical Centre, Chicago, IL, USA.
authors: M
authors: M
authors: Jolly
authors: School of Clinical Sciences at Monash Health, Monash University, Melbourne, Victoria, Australia eric.morand@monash.edu.
authors: E F
authors: EF
authors: Morand
mesh_terms: D000328:Adult; D000368:Aged; D001315:Australia; D006233:Persons with Disabilities; D005163:Factor Analysis, Statistical; D005260:Female; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000503:physiopathology / Q000523:psychology*; D008297:Male; D008875:Middle Aged; D000071066:Patient Reported Outcome Measures; D011594:Psychometrics; D011788:Quality of Life; D015203:Reproducibility of Results; D012720:Severity of Illness Index; D012959:Socioeconomic Factors; D011795:Surveys and Questionnaires; D055815:Young Adult
keywords: Australia; patient-reported outcomes; quality of life; systemic lupus erythematosus