title: Acute Phosphate Nephropathy with Diffuse Tubular Injury Despite Limited Calcium Phosphate Deposition.
abstract: An 86-year-old woman developed acute kidney injury after colonoscopy. A renal biopsy showed diffuse tubular injury with minimal calcium phosphate deposits (CPDs), which were thought to be caused by an oral sodium phosphate bowel purgative before colonoscopy. According to these findings, she was diagnosed with acute phosphate nephropathy (APhN). In contrast to previous reports of diffuse tubular injury associated with tubular CPDs in APhN, this case demonstrated diffuse tubular injury despite a limited distribution of CPDs, suggesting that calcium phosphate can cause tubular injury without deposition. This case thus supports the hypothesis that urinary calcium phosphate crystals may cause tubular injury via other mechanisms, including inflammatory cytokines.
authors: Department of Nephrology, Shinshu University School of Medicine, Japan.
authors: Yosuke
authors: Y
authors: Yamada
authors: Makoto
authors: M
authors: Harada
authors: Akinori
authors: A
authors: Yamaguchi
authors: Mai
authors: M
authors: Sugiyama
authors: Taro
authors: T
authors: Kanno
authors: Koji
authors: K
authors: Hashimoto
authors: Takashi
authors: T
authors: Ehara
authors: Hisashi
authors: H
authors: Shimojo
authors: Hidekazu
authors: H
authors: Shigematsu
authors: Yuji
authors: Y
authors: Kamijo
mesh_terms: D058186:Acute Kidney Injury / Q000139:chemically induced* / Q000473:pathology; D000369:Aged, 80 and over; D002400:Cathartics / Q000008:administration & dosage / Q000009:adverse effects*; D003113:Colonoscopy / Q000009:adverse effects; D005260:Female; D006801:Humans; D010710:Phosphates / Q000008:administration & dosage / Q000009:adverse effects*
chemical_list: D002400:Cathartics; D010710:Phosphates; C018279:sodium phosphate