title: The Effects of Scleral Collagen Cross-Linking Using Glyceraldehyde on the Progression of Form-Deprived Myopia in Guinea Pigs.
abstract: To investigate the effects of collagen cross-linking using glyceraldehyde on the biomechanical properties of the sclera and the axial elongation of form-deprived myopia in the guinea pig. Thirty-six guinea pigs were randomly assigned to four groups: FDM (form-deprived myopia); FDMG (form-deprived myopia treated with glyceraldehyde); FDMS (form-deprived myopia treated with 0.9% isotonic sodium chloride); and normal control (free of form-deprivation). FDM was achieved in the right eye using a latex facemask. The right eye in FDMG was treated with a posterior subtenon injection of 0.5 M glyceraldehyde; 0.9% isotonic sodium chloride was administered to the right eye in FDMS group using the same method. Axial length, refraction, and stress-strain of the sclera were measured at scheduled time points. The treated eyes were also examined histologically by light microscopy. It was found that glyceraldehyde treatment significantly increased the stiffness of the sclera in the FDM eyes and abnormalities have not been observed in the retina and optic nerve of the treated eyes. But the development of myopia was not affected.
authors: Tianjin Eye Hospital, Clinical College of Ophthalmology Tianjin Medical University, No. 4 Gansu Road, Heping District, Tianjin 300020, China.
authors: Yanhua
authors: Y
authors: Chu
authors: Tianjin Medical University Eye Hospital, Tianjin Medical University Eye Institute, No. 251 Fukang Road, Nankai District, Tianjin 300384, China.
authors: Zhaohui
authors: Z
authors: Cheng
authors: Tianjin Eye Hospital, Clinical College of Ophthalmology Tianjin Medical University, No. 4 Gansu Road, Heping District, Tianjin 300020, China.
authors: Jing
authors: J
authors: Liu
authors: Tianjin Eye Hospital, Clinical College of Ophthalmology Tianjin Medical University, No. 4 Gansu Road, Heping District, Tianjin 300020, China.
authors: Ying
authors: Y
authors: Wang
authors: Tianjin Eye Hospital, Clinical College of Ophthalmology Tianjin Medical University, No. 4 Gansu Road, Heping District, Tianjin 300020, China.
authors: Haixia
authors: H
authors: Guo
authors: Tianjin Eye Hospital, Clinical College of Ophthalmology Tianjin Medical University, No. 4 Gansu Road, Heping District, Tianjin 300020, China.
authors: Quanhong
authors: 0000-0002-8567-5968
authors: Q
authors: Han