title: The role of human papilloma virus and herpes viruses in the etiology of nasal polyposis.
abstract: OBJECTIVE
  The aim of this study was to investigate the etiological role of human papilloma virus (HPV), herpes simplex virus (HSV), varicella-zoster virus (VZV), Epstein-Barr virus (EBV), cytomegalovirus (CMV), and human herpes virus-6 (HHV-6) and -7 (HHV-7) in the occurrence of nasal polyposis.
  
  
  METHODS
  Nasal polyp samples from 30 patients with nasal polyposis and normal nasal mucosa from 10 patients without nasal polyps were obtained. DNA was extracted from tissues. Real-time polymerase chain reaction was performed for all runs.
  
  
  RESULTS
  No HSV-1, HSV-2, or VZV was detected in the samples. Among the patient samples, EBV and HHV-7 DNA were detected in 18 (60%), HHV-6 was detected in 20 (66.7%), and HPV was detected in 4 (13.3%) samples. Among the controls, CMV DNA was positive in one (10%). EBV was positive in 5 (50%), HHV-6 and HHV-7 were positive in 7 (70%), and HPV was positive in 2 (20%) samples. No significant difference was found among the groups with any test in terms of positivity.
  
  
  CONCLUSIONS
  The association of Herpesviridae and HPV with the pathogenesis of nasal polyps was investigated in this study and no relationship was found. Thus, these viruses do not play a significant role in the formation of nasal polyps.
authors: Department of Clinical Microbiology, Faculty of Medicine, Abant İzzet Baysal University, Bolu, Turkey.
authors: Mücahide Esra
authors: ME
authors: Koçoğlu
authors: Department of Clinical Microbiology, Faculty of Medicine, Abant İzzet Baysal University, Bolu, Turkey.
authors: Fırat Zafer
authors: FZ
authors: Mengeloğlu
authors: Department of Ear, Nose, and Throat, Faculty of Medicine, Abant İzzet Baysal University, Bolu, Turkey.
authors: Tayfun
authors: T
authors: Apuhan
authors: Department of Clinical Microbiology, Faculty of Medicine, Abant İzzet Baysal University, Bolu, Turkey.
authors: Şeyda
authors: Ş
authors: Özsoy
authors: Department of Ear, Nose, and Throat, Faculty of Medicine, Dicle University, Diyarbakır, Turkey.
authors: Beyhan
authors: B
authors: Yilmaz
mesh_terms: D004279:DNA, Viral; D006566:Herpesviridae Infections; D015654:Herpesvirus 6, Human; D006801:Humans; D009298:Nasal Polyps; D027383:Papillomaviridae
chemical_list: D004279:DNA, Viral
keywords: Herpesviridae; Nasal polyposis; human papilloma virus; pathogenesis