title: Long-term update of the 24954 EORTC phase III trial on larynx preservation.
abstract: The long-term results of the EORTC 24954 trial comparing sequential versus alternating chemotherapy and radiotherapy (RT) for patients with locally advanced laryngeal and hypopharyngeal cancer are reported. From 1996 to 2004, 450 patients were randomly assigned (1-1) to a sequential arm (SA = induction cisplatin-5fluorouracil followed by a 70Gy-RT for the responders or a total laryngectomy and post-operative RT for the non-responders) and an alternating arm (AA = cisplatin-5fluorouracil alternated with three 2-week courses of 20 Gy-RT for a total dose of 60 Gy). Median follow-up was 10.2 years. Ten-year survival with functional larynx (primary end-point) and overall survival were similar in both arms (18.7% and 33.6% in SA versus 18.3% and 31.6% in AA). Late toxicity was also similar; however, a trend for higher larynx preservation and better laryngeal function was observed in AA.
authors: Department of Radiation Oncology, Institut de Recherche Experimentale et Clinique, Université catholique de Louvain, St-Luc University Hospital, Brussels, Belgium. Electronic address: b.henriques@bordeaux.unicancer.fr.
authors: B
authors: B
authors: Henriques De Figueiredo
authors: EORTC Headquarters, Brussels, Belgium.
authors: C
authors: C
authors: Fortpied
authors: EORTC Headquarters, Brussels, Belgium.
authors: J
authors: J
authors: Menis
authors: Department of Head and Neck Cancer, Centre Oscar Lambret, Lille, France.
authors: J L
authors: JL
authors: Lefebvre
authors: Department of Surgery, Centro di Riferimento Oncologico, Aviano, Italy.
authors: L
authors: L
authors: Barzan
authors: Department of Head and Neck Surgery, Centre François Baclesse, Caen, France.
authors: D
authors: D
authors: de Raucourt
authors: Department of Medical Oncology, Centre Alexis Vautrin, Nancy, France.
authors: L
authors: L
authors: Geoffrois
authors: EORTC Headquarters, Brussels, Belgium.
authors: L
authors: L
authors: Giurgea
authors: Department of Internal Medicine, University Hospital, Maastricht, The Netherlands.
authors: P
authors: P
authors: Hupperets
authors: Department of Otolaryngology/Head and Neck Surgery, VU University Medical Center/Cancer Center, Amsterdam, The Netherlands.
authors: C R
authors: CR
authors: Leemans
authors: Department of Head and Neck Medical Oncology, Fondazione IRCCS Istituto dei Tumori, Milan, Italy.
authors: L
authors: L
authors: Licitra
authors: Department of Oncology, Institut de Cancérologie de l'Ouest, Nantes, France.
authors: F
authors: F
authors: Rolland
authors: Department of Radiotherapy, University Hospital, Leiden, The Netherlands.
authors: M
authors: M
authors: Tesselaar
authors: Department of Medical Oncology, Antwerp University Hospital, Edegem, Belgium.
authors: J B
authors: JB
authors: Vermorken
authors: Department of Radiation Oncology, Institut de Recherche Experimentale et Clinique, Université catholique de Louvain, St-Luc University Hospital, Brussels, Belgium.
authors: V
authors: V
authors: Grégoire
mesh_terms: D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002294:Carcinoma, Squamous Cell / Q000473:pathology / Q000628:therapy*; D059248:Chemoradiotherapy / Q000379:methods*; D002945:Cisplatin / Q000008:administration & dosage; D018450:Disease Progression; D019583:Dose Fractionation, Radiation; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage; D006801:Humans; D007012:Hypopharyngeal Neoplasms / Q000473:pathology / Q000628:therapy*; D007822:Laryngeal Neoplasms / Q000473:pathology / Q000628:therapy*; D007825:Laryngectomy; D007830:Larynx; D008297:Male; D008875:Middle Aged; D059351:Organ Sparing Treatments / Q000379:methods*; D016019:Survival Analysis; D055815:Young Adult
chemical_list: D002945:Cisplatin; D005472:Fluorouracil
keywords: Larynx preservation; Late toxicity; Radiochemotherapy