title: The Influence of Statin Therapy on Restenosis in Patients Who Underwent Nitinol Stent Implantation for de Novo Femoropopliteal Artery Disease: Two-Year Follow-up at a Single Center.
abstract: OBJECTIVE
  To determine whether statin therapy is associated with reduced restenosis following nitinol stent implantation for de novo femoropopliteal artery disease.
  
  
  METHODS
  A total of 135 limbs in 135 patients (mean age, 72 y) implanted with nitinol stents in femoropopliteal occlusions were analyzed (statin arm, n = 91; nonstatin arm, n = 44). The patients were treated with one type of nitinol stent.
  
  
  RESULTS
  At baseline, lesions and procedural characteristics were comparable between groups, except that the statin group had more hypertension, coronary artery disease, and hyperlipidemia. There were significant differences in the incidence of binary restenosis between groups at 1 year (45.5% for nonstatin group vs 28.6% for statin group; P = .05) and 2 years (56.8% for nonstatin group vs 38.5% for statin group; P = .04). Primary patency rates at 1 year were 50.5% in the nonstatin group and 72.5% in the statin group (P = .01). Two-year target lesion revascularization rates were 54.5% in the nonstatin group and 35.2% in the statin group (P = .03). On univariate analysis, statin therapy was associated with decreased relative risk of binary restenosis at 1 year (odds ratio [OR], 0.480; 95% confidence interval [CI], 0.227-1.014; P = .050). On multivariate analysis, statin therapy did not significantly affect the odds of binary restenosis (OR, 0.415; 95% CI, 0.071-2.437; P = .330).
  
  
  CONCLUSIONS
  The incidence of binary restenosis was significantly lower in the statin group than in the nonstatin group following nitinol stent implantation for de novo femoropopliteal artery disease.
authors: Division of Interventional Radiology, Miami Cardiac and Vascular Institute, 8900 N. Kendall Dr., Miami, FL 33176; Department of Medical and Population Health Sciences Research, Herbert Wertheim College of Medicine, Florida International University, Miami, Florida; Division of Cardiology, Eulji University Hospital, Eulji University School of Medicine, Daejeon, Republic of Korea.
authors: Wonho
authors: W
authors: Kim
authors: Division of Interventional Radiology, Miami Cardiac and Vascular Institute, 8900 N. Kendall Dr., Miami, FL 33176.
authors: Ripal T
authors: RT
authors: Gandhi
authors: Division of Interventional Radiology, Miami Cardiac and Vascular Institute, 8900 N. Kendall Dr., Miami, FL 33176.
authors: Constantino S
authors: CS
authors: Peña
authors: Division of Interventional Radiology, Miami Cardiac and Vascular Institute, 8900 N. Kendall Dr., Miami, FL 33176.
authors: Raul E
authors: RE
authors: Herrera
authors: Division of Interventional Radiology, Miami Cardiac and Vascular Institute, 8900 N. Kendall Dr., Miami, FL 33176.
authors: Melanie B
authors: MB
authors: Schernthaner
authors: Department of Medical and Population Health Sciences Research, Herbert Wertheim College of Medicine, Florida International University, Miami, Florida.
authors: Juan M
authors: JM
authors: Acuña
authors: Department of Medical and Population Health Sciences Research, Herbert Wertheim College of Medicine, Florida International University, Miami, Florida.
authors: Victor N
authors: VN
authors: Becerra
authors: Division of Interventional Radiology, Miami Cardiac and Vascular Institute, 8900 N. Kendall Dr., Miami, FL 33176. Electronic address: btkatzen@aol.com.
authors: Barry T
authors: BT
authors: Katzen
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000497:Alloys; D057510:Endovascular Procedures / Q000009:adverse effects / Q000295:instrumentation*; D005260:Female; D005263:Femoral Artery / Q000000981:diagnostic imaging / Q000503:physiopathology; D005431:Florida; D005500:Follow-Up Studies; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000627:therapeutic use*; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D016017:Odds Ratio; D058729:Peripheral Arterial Disease / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000628:therapy*; D011150:Popliteal Artery / Q000000981:diagnostic imaging / Q000503:physiopathology; D011474:Prosthesis Design; D065840:Protective Factors; D012008:Recurrence; D012189:Retrospective Studies; D012307:Risk Factors; D015607:Stents; D013997:Time Factors; D016896:Treatment Outcome; D014654:Vascular Patency
chemical_list: D000497:Alloys; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; C013616:nitinol