title: Kidney activity increases in copper exposed goldfish (Carassius auratus auratus).
abstract: In the present study, the effect of copper was examined in the common goldfish (Carassius auratus auratus). Fish were fasted and exposed to either a high (0.84μM), a low (0.34μM) or a control copper concentration (0.05μM) for 1 and 7days. Swimming performance was not affected by either fasting or copper exposure. Food deprivation alone had no effect on ionoregulation, but low plasma osmolality levels and plasma Na+were noticed in fasted fish exposed to Cu for 7days. Both gill Na+/K+-ATPase and H+-ATPase activities were undisturbed, while both kidney ATPase activities were up-regulated when challenged with the high Cu levels. Up-regulated kidney ATPase activities likely acted as compensatory strategy to enhance Na+reabsorption. However, this up-regulation was not sufficient to restore Na+to control levels in the highest exposure group.
authors: Systemic Physiological and Ecotoxicological Research, Department of Biology, University of Antwerp, Groenenborgerlaan 171, BE-2020 Antwerp, Belgium. Electronic address: Sofie.Moyson@uantwerpen.be.
authors: Sofie
authors: S
authors: Moyson
authors: Systemic Physiological and Ecotoxicological Research, Department of Biology, University of Antwerp, Groenenborgerlaan 171, BE-2020 Antwerp, Belgium; Institute of Tropical Aquaculture, Universiti Malaysia Terengganu, 21030, Kuala Terengganu, Terengganu, Malaysia.
authors: Hon Jung
authors: HJ
authors: Liew
authors: Department of Biological and Environmental Science, University of Messina, Viale Ferdinando Stagno d'Alcontres 31, 98166 S.Agata, Messina, Italy.
authors: Angela
authors: A
authors: Fazio
authors: Systemic Physiological and Ecotoxicological Research, Department of Biology, University of Antwerp, Groenenborgerlaan 171, BE-2020 Antwerp, Belgium.
authors: Nathalie
authors: N
authors: Van Dooren
authors: Systemic Physiological and Ecotoxicological Research, Department of Biology, University of Antwerp, Groenenborgerlaan 171, BE-2020 Antwerp, Belgium.
authors: Aline
authors: A
authors: Delcroix
authors: Department of Biological and Environmental Science, University of Messina, Viale Ferdinando Stagno d'Alcontres 31, 98166 S.Agata, Messina, Italy.
authors: Caterina
authors: C
authors: Faggio
authors: Systemic Physiological and Ecotoxicological Research, Department of Biology, University of Antwerp, Groenenborgerlaan 171, BE-2020 Antwerp, Belgium.
authors: Ronny
authors: R
authors: Blust
authors: Systemic Physiological and Ecotoxicological Research, Department of Biology, University of Antwerp, Groenenborgerlaan 171, BE-2020 Antwerp, Belgium.
authors: Gudrun
authors: G
authors: De Boeck
mesh_terms: D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D019327:Copper Sulfate / Q000633:toxicity*; D004305:Dose-Response Relationship, Drug; D029941:Fish Proteins / Q000378:metabolism*; D005880:Gills / Q000187:drug effects / Q000201:enzymology; D006054:Goldfish / Q000097:blood / Q000378:metabolism*; D007668:Kidney / Q000187:drug effects* / Q000201:enzymology; D009994:Osmolar Concentration; D006180:Proton-Translocating ATPases / Q000378:metabolism*; D012964:Sodium / Q000097:blood; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism*; D013550:Swimming; D013997:Time Factors; D015854:Up-Regulation
chemical_list: D029941:Fish Proteins; D012964:Sodium; D006180:Proton-Translocating ATPases; D000254:Sodium-Potassium-Exchanging ATPase; D019327:Copper Sulfate
keywords: ATPase; Heavy metal; Ionoregulation; Osmolality; Shubunkin; Swimming performance; Toxicity