title: Nanopore-CMOS Interfaces for DNA Sequencing.
abstract: DNA sequencers based on nanopore sensors present an opportunity for a significant break from the template-based incumbents of the last forty years. Key advantages ushered by nanopore technology include a simplified chemistry and the ability to interface to CMOS technology. The latter opportunity offers substantial promise for improvement in sequencing speed, size and cost. This paper reviews existing and emerging means of interfacing nanopores to CMOS technology with an emphasis on massively-arrayed structures. It presents this in the context of incumbent DNA sequencing techniques, reviews and quantifies nanopore characteristics and models and presents CMOS circuit methods for the amplification of low-current nanopore signals in such interfaces.
authors: Department of Electrical Engineering and Computer Science, York University, 6400 Keele St, Toronto, ON M3J-1P3, Canada. magiero@eecs.yorku.ca.
authors: Sebastian
authors: S
authors: Magierowski
authors: Department of Electrical Engineering and Computer Science, York University, 6400 Keele St, Toronto, ON M3J-1P3, Canada. yiyun@eecs.yorku.ca.
authors: Yiyun
authors: Y
authors: Huang
authors: Department of Electrical Engineering and Computer Science, York University, 6400 Keele St, Toronto, ON M3J-1P3, Canada. chengjie@eecs.yorku.ca.
authors: Chengjie
authors: C
authors: Wang
authors: Department of Electrical Engineering and Computer Science, York University, 6400 Keele St, Toronto, ON M3J-1P3, Canada. egz@eecs.yorku.ca.
authors: Ebrahim
authors: E
authors: Ghafar-Zadeh
mesh_terms: D000465:Algorithms; D015374:Biosensing Techniques; D004581:Electronics / Q000295:instrumentation / Q000379:methods; D059014:High-Throughput Nucleotide Sequencing; D008670:Metals; D008962:Models, Theoretical; D058608:Nanopores; D036103:Nanotechnology; D010087:Oxides; D012666:Semiconductors; D017422:Sequence Analysis, DNA / Q000379:methods
chemical_list: D008670:Metals; D010087:Oxides
keywords: CMOS; microelectronics; nanopore arrays; nanopore sensors; sequencing; transimpedance amplification