title: Age-Related Differences of Organism-Specific Peritonitis Rates: A Single-Center Experience.
abstract: Peritonitis remains an important cause of morbidity and mortality in peritoneal dialysis (PD) patients, but its incidence and the distribution of causative organisms vary widely between institutions and age groups. This study was performed to investigate the recent status and risk factors of PD-related peritonitis and to clarify differences between age groups. We retrospectively reviewed the medical records of 119 PD patients treated at our department between January 2002 and January 2013. We calculated both overall and organism-specific peritonitis rates and also analyzed risk factors. Sixty-three episodes of peritonitis occurred during 261.5 patient-years for an incident rate of 0.24 episodes/patient-year. Multivariate analysis showed that older age (≥65 years) and hypoalbuminemia (<3.0 g/dL) were associated with an increased risk of peritonitis (P = 0.035 and P = 0.029, respectively). In elderly patients (≥65 years old), the rate of peritonitis due to Gram-positive and Gram-negative bacteria was 0.17 and 0.08 episodes/patient-year, respectively, and Gram-positive peritonitis was markedly more frequent than in younger patients (<65 years old). In particular, there was a high frequency of Staphylococcus aureus peritonitis in elderly patients (0.09 episodes/patient-year) and it had a poor outcome. At our department, the risk of peritonitis was increased in older patients and patients with hypoalbuminemia. The distribution of causative organisms was markedly different between age groups and analysis of organism-specific peritonitis rates helped to identify current problems with our PD program.
authors: Department of Nephrology, Division of Internal Medicine, Mitsui Memorial Hospital, Tokyo, Japan.|Kugayama Kidney Clinic, Tokyo, Japan.
authors: Nagaaki
authors: N
authors: Kotera
authors: Department of Nephrology, Division of Internal Medicine, Mitsui Memorial Hospital, Tokyo, Japan.|Department of Nephrology and Endocrinology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
authors: Mototsugu
authors: M
authors: Tanaka
authors: Department of Nephrology, Division of Internal Medicine, Mitsui Memorial Hospital, Tokyo, Japan.
authors: Mari
authors: M
authors: Aoe
authors: Department of Nephrology, Division of Internal Medicine, Mitsui Memorial Hospital, Tokyo, Japan.
authors: Masatomo
authors: M
authors: Chikamori
authors: Department of Nephrology, Division of Internal Medicine, Mitsui Memorial Hospital, Tokyo, Japan.
authors: Tomoko
authors: T
authors: Honda
authors: Department of Nephrology, Division of Internal Medicine, Mitsui Memorial Hospital, Tokyo, Japan.
authors: Ayako
authors: A
authors: Ikenouchi
authors: Department of Nephrology, Division of Internal Medicine, Mitsui Memorial Hospital, Tokyo, Japan.
authors: Rika
authors: R
authors: Miura
authors: Department of Nephrology, Division of Internal Medicine, Mitsui Memorial Hospital, Tokyo, Japan.
authors: Mai
authors: M
authors: Sugahara
authors: Department of Nephrology, Division of Internal Medicine, Mitsui Memorial Hospital, Tokyo, Japan.
authors: Satoshi
authors: S
authors: Furuse
authors: Department of Nephrology, Division of Internal Medicine, Mitsui Memorial Hospital, Tokyo, Japan.
authors: Katsunori
authors: K
authors: Saito
authors: Department of Nephrology, Division of Internal Medicine, Mitsui Memorial Hospital, Tokyo, Japan.
authors: Naobumi
authors: N
authors: Mise
mesh_terms: D000367:Age Factors; D000368:Aged; D055499:Catheter-Related Infections / Q000453:epidemiology*; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D010530:Peritoneal Dialysis / Q000009:adverse effects / Q000295:instrumentation / Q000706:statistics & numerical data*; D010538:Peritonitis / Q000453:epidemiology*; D012189:Retrospective Studies; D012307:Risk Factors; D013203:Staphylococcal Infections / Q000453:epidemiology*; D013211:Staphylococcus aureus; D016896:Treatment Outcome
keywords: Elderly patients; Hypoalbuminemia; Organism-specific rate; Peritoneal dialysis; Peritonitis