title: Australian Group on Antimicrobial Resistance Australian Enterobacteriaceae Sepsis Outcome Programme annual report, 2014.
abstract: The Australian Group on Antimicrobial Resistance performs regular period-prevalence studies to monitor changes in antimicrobial resistance in selected enteric Gram-negative pathogens. The 2014 survey was the second year to focus on blood stream infections. During 2014, 5,798 Enterobacteriaceae species isolates were tested using commercial automated methods (Vitek 2, BioMérieux; Phoenix, BD) and results were analysed using the Clinical and Laboratory Standards Institute (CLSI) and European Committee on Antimicrobial Susceptibility Testing (EUCAST) breakpoints (January 2015). Of the key resistances, non-susceptibility to the third-generation cephalosporin, ceftriaxone, was found in 9.0%/9.0% of Escherichia coli (CLSI/EUCAST criteria) and 7.8%/7.8% of Klebsiella pneumoniae, and 8.0%/8.0% K. oxytoca. Non-susceptibility rates to ciprofloxacin were 10.4%/11.6% for E. coli, 5.0%/7.7% for K. pneumoniae, 0.4%/0.4% for K. oxytoca, and 3.5%/6.5% in Enterobacter cloacae. Resistance rates to piperacillin-tazobactam were 3.2%/6.8%, 4.8%/7.2%, 11.1%/11.5%, and 19.0%/24.7% for the same 4 species respectively. Fourteen isolates were shown to harbour a carbapenemase gene, 7 blaIMP-4, 3 blaKPC-2, 3 blaVIM-1, 1 blaNDM-4, and 1 blaOXA-181-lke.
authors: Departments of Pathology, Paediatrics and Molecular and Biomedical Sciences, University of Adelaide, Adelaide, South Australia.
authors: Jan M
authors: JM
authors: Bell
authors: Microbiology and Infectious Diseases Directorate, SA Pathology, Adelaide, South Australia.
authors: John D
authors: JD
authors: Turnidge
authors: Australian Collaborating Centre for Enterococcus and Staphylococcus Species (ACCESS) Typing and Research, School of Veterinary and Life Sciences, Murdoch University, Murdoch, Western Australia.|Department of Microbiology and Infectious Diseases, PathWest Laboratory Medicine-WA, Fiona Stanley Hospital, Murdoch, Western Australia.
authors: Geoffrey W
authors: GW
authors: Coombs
authors: Australian Group on Antimicrobial Resistance, Fiona Stanley Hospital, Murdoch, Western Australia.
authors: Denise A
authors: DA
authors: Daley
authors: Concord Hospital, Concord, New South Wales.
authors: Thomas
authors: T
authors: Gottlieb
authors: Sullivan Nicolaides Pathology, Queensland.
authors: Jenny
authors: J
authors: Robson
authors: Microbiology, Pathology Queensland, Royal Brisbane and Women's Hospital, Herston, Queensland.
authors: Narelle
authors: N
authors: George
mesh_terms: D000847:Annual Reports as Topic; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001315:Australia / Q000453:epidemiology; D016470:Bacteremia / Q000453:epidemiology / Q000266:history / Q000382:microbiology; D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism; D024881:Drug Resistance, Bacterial; D004755:Enterobacteriaceae / Q000145:classification / Q000187:drug effects* / Q000235:genetics / Q000302:isolation & purification; D004756:Enterobacteriaceae Infections / Q000453:epidemiology* / Q000266:history / Q000382:microbiology*; D049674:History, 21st Century; D006801:Humans; D008826:Microbial Sensitivity Tests; D058889:Molecular Typing; D063868:Patient Outcome Assessment; D011159:Population Surveillance; D018805:Sepsis / Q000453:epidemiology* / Q000382:microbiology*; D001618:beta-Lactamases / Q000235:genetics / Q000378:metabolism
chemical_list: D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D001618:beta-Lactamases; C063912:carbapenemase