title: MicroRNAs as Novel Biomarkers of Deployment Status and Exposure to Polychlorinated Dibenzo-p-Dioxins/Dibenzofurans.
abstract: To determine if service members deployed to locations with open air burn pits have different serum microRNA (miRNA) profiles after deployment compared with length-of-service matched, non-deployed individuals. We also tested for correlations between miRNA and serum levels of Polychlorinated Dibenzo-p-Dioxins/Dibenzofurans (PCDD/PCDFs).
  
  
  
  MiRNAs were isolated and quantified by PCR array. Groups were analyzed for differences in miRNA expression. Correlations between serum miRNA and PCDD/PCDFs were assessed with a linear regression model.
  
  
  
  Several miRNAs were differentially expressed after deployment and a partially overlapping set of miRNAs were identified between deployed and non-deployed individuals. Significant correlations between miRNAs and PCDD/PCDFs were identified.
  
  
  
  Serum miRNA levels show a link between deployment to locations with open burn pits and environmental exposures that can take place during deployment.
authors: Department of Environmental Medicine (Dr Woeller, Mr Pollock, Ms Croasdell, Dr Sime, Dr Utell, and Dr Phipps), Department of Medicine (Dr Thatcher, Dr Sime, Dr Utell, and Dr Phipps), Microbiology and Immunology (Mr Van Twisk, Dr Thakar, and Dr Phipps), and Department of Biostatistics and Computational Biology (Mr Van Twisk, Dr Thakar), University of Rochester Medical Center; Center for Air Resources Engineering and Science, Clarkson University, Potsdam, New York (Dr Hopke, Dr Xia); and Professor, Department of Preventive Medicine and Biostatistics, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD 20814 (Dr Mallon).
authors: Collynn F
authors: CF
authors: Woeller
authors: Thomas H
authors: TH
authors: Thatcher
authors: Daniel
authors: D
authors: Van Twisk
authors: Stephen J
authors: SJ
authors: Pollock
authors: Amanda
authors: A
authors: Croasdell
authors: Philip K
authors: PK
authors: Hopke
authors: Xiaoyan
authors: X
authors: Xia
authors: Juilee
authors: J
authors: Thakar
authors: Patricia J
authors: PJ
authors: Sime
authors: Timothy M
authors: TM
authors: Mallon
authors: Mark J
authors: MJ
authors: Utell
authors: Richard P
authors: RP
authors: Phipps
mesh_terms: D000395:Air Pollutants, Occupational; D015415:Biomarkers / Q000097:blood; D000072338:Dibenzofurans, Polychlorinated / Q000097:blood*; D004781:Environmental Exposure / Q000032:analysis*; D004784:Environmental Monitoring; D006801:Humans; D017745:Incineration; D035683:MicroRNAs / Q000097:blood*; D008889:Military Personnel; D016273:Occupational Exposure / Q000032:analysis*; D000072317:Polychlorinated Dibenzodioxins / Q000097:blood*
chemical_list: D000395:Air Pollutants, Occupational; D015415:Biomarkers; D000072338:Dibenzofurans, Polychlorinated; D035683:MicroRNAs; D000072317:Polychlorinated Dibenzodioxins