title: Paraneoplastic Dermatosis in a Patient with Anaplastic Large-Cell Lymphoma: Case Report and Literature Review.
abstract: OBJECTIVE
  Paraneoplastic dermatoses are skin disorders that are associated with malignancy. Anaplastic large T-cell lymphoma (ALTCL) has rarely been associated with paraneoplastic skin manifestations such as gangrenous foot ulcers and erythroderma.
  
  
  METHODS
  We describe a case of ALTCL presenting as a large annular skin rash. The clinical picture, course, and treatment will be discussed along with current hypotheses on the mechanism of paraneoplastic syndromes.
  
  
  RESULTS
  Skin manifestations in ALTCL most commonly arise in two distinct ways; either as primary cutaneous lymphoma manifestation or as systemic disease with secondary metastasis. Less commonly, systemic disease causes skin manifestations secondary to a paraneoplastic process without infiltration of malignant cells. This is thought to be mediated by an immunologic reaction to tumor antigen or the result of cytokines and other inflammatory markers produced by the tumor itself.
  
  
  CONCLUSIONS
  Paraneoplastic dermatoses could be the initial presentations of systemic lymphoma. Knowledge about their association with anaplastic large-cell lymphoma may help with timely diagnosis. In a patient with unexplained dermatosis associated with B symptoms who is unresponsive to topic treatment, an investigation for systemic lymphoma workup is warranted.
authors: Department of Internal Medicine, William Beaumont Hospital, Oakland University William Beaumont School Medicine, Royal Oak, Mich., USA.
authors: Travis
authors: T
authors: Tagami
authors: Department of Internal Medicine, William Beaumont Hospital, Oakland University William Beaumont School Medicine, Royal Oak, Mich., USA.
authors: Omar
authors: O
authors: Alhalabi
authors: Department of Pathology, William Beaumont Hospital, Oakland University William Beaumont School Medicine, Royal Oak, Mich., USA.
authors: Nicholas
authors: N
authors: Ward
authors: Department of Pathology, William Beaumont Hospital, Oakland University William Beaumont School Medicine, Royal Oak, Mich., USA.
authors: James
authors: J
authors: Huang
keywords: Anaplastic large-cell lymphoma; Literature review; Paraneoplastic dermatosis