title: Bone turnover markers and bone mineral density in healthy mother-daughter pairs from South India.
abstract: Bone turnover markers (BTMs) provide important insights into the dynamics of bone remodelling and are subjected to preanalytical and ethnic variations in addition to influence of genetic and environmental factors.
  
  
  OBJECTIVE
  To derive ethnicity specific reference range for BTMs and to study their correlation with Bone Mineral Density (BMD) in a cohort of healthy postmenopausal women and their premenopausal daughters and to look at the impact of maternal bone mineral status on daughters bone health.
  
  
  METHODS
  This community based cross sectional study included 300 subjects (150 mother-daughter pairs). Demographic details were collected. Fasting blood and a second void morning urine samples were obtained for measurement of BTMs (sCTX, sPTNP1, sOC and urine DPD respectively) and bone mineral parameters. BMD was measured by DXA scan.
  
  
  RESULTS
  Osteoporosis was seen in 44·7% of the postmenopausal women. Ethnicity specific reference ranges of BTMs were derived for the study population. Significant inverse correlation was found between all BTMs (except urine DPD) and BMD(P < 0·05). Daughters of mothers with osteoporosis at spine and femoral neck had lower BMD, compared to daughters of mothers without osteoporosis(P = 0·03 & 0·05).
  
  
  CONCLUSIONS
  Apart from deriving the ethnicity specific reference range for BTMs and finding a significant inverse correlation between BTM and BMD, this study found significantly lower BMD in daughters of mothers with osteoporosis at spine and femoral neck implicating the probable interplay of genetic, epigenetic and similar environmental factors.
authors: Department of Endocrinology, Diabetes & Metabolism, Christian Medical College, Vellore, India.
authors: Sahana
authors: S
authors: Shetty
authors: Department of Endocrinology, Diabetes & Metabolism, Christian Medical College, Vellore, India.
authors: Nitin
authors: N
authors: Kapoor
authors: Department of Clinical Biochemistry, Christian Medical College, Vellore, India.
authors: Joseph
authors: J
authors: Dian Bondu
authors: Department of Biostatistics, Christian Medical College, Vellore, India.
authors: Belavendra
authors: B
authors: Antonisamy
authors: Department of Endocrinology, Diabetes & Metabolism, Christian Medical College, Vellore, India.
authors: Nihal
authors: N
authors: Thomas
authors: Department of Endocrinology, Diabetes & Metabolism, Christian Medical College, Vellore, India. thomasvpaul@yahoo.com.
authors: Thomas Vizhalil
authors: TV
authors: Paul
mesh_terms: D015502:Absorptiometry, Photon; D000328:Adult; D015415:Biomarkers / Q000097:blood / Q000652:urine; D015519:Bone Density; D016723:Bone Remodeling; D003430:Cross-Sectional Studies; D005260:Female; D005272:Femur Neck / Q000473:pathology; D006801:Humans; D007194:India; D008875:Middle Aged; D009035:Mothers; D009679:Nuclear Family; D010024:Osteoporosis / Q000175:diagnosis / Q000208:ethnology* / Q000209:etiology* / Q000235:genetics; D017698:Postmenopause; D017697:Premenopause; D013131:Spine / Q000473:pathology
chemical_list: D015415:Biomarkers