title: New inflammatory parameters in laryngopharyngeal reflux.
abstract: OBJECTIVE
  To investigate new inflammatory markers in patients with laryngopharyngeal reflux and determine whether these inflammatory parameters change in response to laryngopharyngeal reflux treatment.
  
  
  METHODS
  Complete blood count was evaluated to obtain platelet count and mean platelet volume and calculate neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio. Laryngopharyngeal reflux patients underwent three-month lansoprazole treatment.
  
  
  RESULTS
  The study included 45 laryngopharyngeal reflux patients (9 men (20 per cent); mean age, 37.4 ± 11.6 years) and 35 healthy age- and sex-matched controls (7 men (20 per cent); mean age, 38.6 ± 8.9 years). The study group had significantly higher platelet-to-lymphocyte ratios and lower mean platelet volumes than the control group (p = 0.004 and p = 0.047, respectively). There was a significant correlation between platelet-to-lymphocyte ratios and initial inflammatory symptoms (reflux symptom index, p = 0.025; reflux finding score, p = 0.013). There was also a significant correlation between mean platelet volume increase and symptom resolution in the first and third months of treatment (p = 0.04 and p = 0.03, respectively).
  
  
  CONCLUSIONS
  Platelet-to-lymphocyte ratio, a new inflammatory marker of chronic inflammation, was significantly higher in laryngopharyngeal reflux patients. Moreover, these patients had significantly lower mean platelet volume values, which increased with post-treatment symptom improvement.
authors: Department of Otorhinolaryngology,Ufuk University Medical School,Ankara,Turkey.
authors: H
authors: H
authors: Arslan
authors: Department of Biochemistry,Ufuk University Medical School,Ankara,Turkey.
authors: T
authors: T
authors: Çandar
authors: Department of Gastroenterology,Çukurova University Medical School,Adana,Turkey.
authors: S
authors: S
authors: Kuran
authors: Department of Otorhinolaryngology,Ufuk University Medical School,Ankara,Turkey.
authors: Ş H
authors: ŞH
authors: Akmansu
authors: Department of Otorhinolaryngology,Ufuk University Medical School,Ankara,Turkey.
authors: S
authors: S
authors: Kocatürk
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D006801:Humans; D007249:Inflammation / Q000097:blood* / Q000209:etiology; D064747:Lansoprazole / Q000627:therapeutic use; D057045:Laryngopharyngeal Reflux / Q000097:blood* / Q000150:complications / Q000188:drug therapy; D018655:Lymphocyte Count; D008297:Male; D063847:Mean Platelet Volume; D010976:Platelet Count; D054328:Proton Pump Inhibitors / Q000627:therapeutic use
chemical_list: D015415:Biomarkers; D054328:Proton Pump Inhibitors; D064747:Lansoprazole
keywords: Laryngopharyngeal Reflux; Lymphocyte; Mean Platelet Volume; Neutrophil; Platelet