title: The Impact of the Stage and Tumor Size on Rare Brain Metastasis of Cervical Cancer.
abstract: OBJECTIVE
  To investigate the clinical features, prognostic factors and survival times of cervical cancer patients with brain metastasis.
  
  
  METHODS
  We retrospectively reviewed the medical records of 820 patients with cervical cancer. Data were analyzed using SPSS version 12.0 statistical software (SPSS, Chicago, IL, USA). Overall survival, time interval from diagnosis of cervical cancer to identification of brain metastasis, and median survival time after diagnosis of brain metastasis were calculated using Kaplan-Meier curve analysis. The log-rank test was used to compare differences in survival. Differences were assumed statistically significant when p-values were < 0.05.
  
  
  RESULTS
  The incidence of brain metastases from cervical cancer in our institution was 1.82% (15/820) over a ten-year period. The median time interval from diagnosis of cervical cancer to detection of brain metastasis was 12.5 months (range: 2.9-91.9 months). Stage and tumor diameter were found to be significant relating to the interval from diagnosis of cervical cancer to detection of brain metastasis (p=0.001 for both).
  
  
  CONCLUSIONS
  This study provides much information about the prognosis of patients with brain metastases from cervical cancer and highlights the importance of initial stage and tumor diameter when determining the time interval until development of brain metastasis.
authors: Dicle University, Medical School, Department of Radiation Oncology, Diyarbakır, Turkey.
authors: Fatma
authors: F
authors: Teke
authors: Senem Yaman
authors: SY
authors: Tunc
authors: Memik
authors: M
authors: Teke
authors: Yahya
authors: Y
authors: Turan
authors: Zuhat
authors: Z
authors: Urakci
authors: Bekir
authors: B
authors: Eren
authors: Suleyman
authors: S
authors: Altin
authors: Mustafa
authors: M
authors: Unsal
mesh_terms: D000328:Adult; D000368:Aged; D001932:Brain Neoplasms / Q000175:diagnosis / Q000473:pathology* / Q000556:secondary*; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D008875:Middle Aged; D011379:Prognosis; D012189:Retrospective Studies; D002583:Uterine Cervical Neoplasms / Q000473:pathology*