title: Increased maternal consumption of methionine as its hydroxyl analog promoted neonatal intestinal growth without compromising maternal energy homeostasis.
abstract: BACKGROUND
  To determine responses of neonatal intestine to maternal increased consumption of DL-methionine (DLM) or DL-2-hydroxy-4-methylthiobutanoic acid (HMTBA), eighteen primiparous sows (Landrace × Yorkshire) were allocated based on body weight and backfat thickness to the control, DLM and HMTBA groups (n = 6), with the nutritional treatments introduced from postpartum d0 to d14.
  
  
  RESULTS
  The DLM-fed sows showed negative energy balance manifested by lost bodyweight, lower plasma glucose, subdued tricarboxylic acid cycle, and increased plasma lipid metabolites levels. Both villus height and ratio of villus height to crypt depth averaged across the small intestine of piglets were higher in the DLM and HMTBA groups than in the control group. Piglet jejunal oxidized glutathione concentration and ratio of oxidized to reduced glutathione were lower in the HMTBA group than in the DLM and control groups. However, piglet jejunal aminopeptidase A, carnitine transporter 2 and IGF-II precursor mRNA abundances were higher in the DLM group than in the HMTBA and control groups.
  
  
  CONCLUSIONS
  Increasing maternal consumption of methionine as DLM and HMTBA promoted neonatal intestinal growth by increasing morphological development or up-regulating expression of genes responsible for nutrient metabolism. And increasing maternal consumption of HMTBA promoted neonatal intestinal antioxidant capacity without compromising maternal energy homeostasis during early lactation.
authors: Key Laboratory for Animal Disease Resistance Nutrition of the Ministry of Education, Animal Nutrition Institute, Sichuan Agricultural University, Ya'an, 625014 China.
authors: Heju
authors: H
authors: Zhong
authors: Key Laboratory for Animal Disease Resistance Nutrition of the Ministry of Education, Animal Nutrition Institute, Sichuan Agricultural University, Ya'an, 625014 China.
authors: Hao
authors: H
authors: Li
authors: Key Laboratory for Animal Disease Resistance Nutrition of the Ministry of Education, Animal Nutrition Institute, Sichuan Agricultural University, Ya'an, 625014 China.
authors: Guangmang
authors: G
authors: Liu
authors: Key Laboratory for Animal Disease Resistance Nutrition of the Ministry of Education, Animal Nutrition Institute, Sichuan Agricultural University, Ya'an, 625014 China.
authors: Haifeng
authors: H
authors: Wan
authors: Adisseo France S.A.S., CERN, Commentry, France.
authors: Yves
authors: Y
authors: Mercier
authors: Key Laboratory for Animal Disease Resistance Nutrition of the Ministry of Education, Animal Nutrition Institute, Sichuan Agricultural University, Ya'an, 625014 China.
authors: Xiaoling
authors: X
authors: Zhang
authors: Key Laboratory for Animal Disease Resistance Nutrition of the Ministry of Education, Animal Nutrition Institute, Sichuan Agricultural University, Ya'an, 625014 China.
authors: Yan
authors: Y
authors: Lin
authors: Key Laboratory for Animal Disease Resistance Nutrition of the Ministry of Education, Animal Nutrition Institute, Sichuan Agricultural University, Ya'an, 625014 China.
authors: Lianqiang
authors: L
authors: Che
authors: Key Laboratory for Animal Disease Resistance Nutrition of the Ministry of Education, Animal Nutrition Institute, Sichuan Agricultural University, Ya'an, 625014 China.
authors: Shengyu
authors: S
authors: Xu
authors: Key Laboratory for Animal Disease Resistance Nutrition of the Ministry of Education, Animal Nutrition Institute, Sichuan Agricultural University, Ya'an, 625014 China.
authors: Li
authors: L
authors: Tang
authors: Key Laboratory for Animal Disease Resistance Nutrition of the Ministry of Education, Animal Nutrition Institute, Sichuan Agricultural University, Ya'an, 625014 China.
authors: Gang
authors: G
authors: Tian
authors: Key Laboratory for Animal Disease Resistance Nutrition of the Ministry of Education, Animal Nutrition Institute, Sichuan Agricultural University, Ya'an, 625014 China.
authors: Daiwen
authors: D
authors: Chen
authors: Key Laboratory for Animal Disease Resistance Nutrition of the Ministry of Education, Animal Nutrition Institute, Sichuan Agricultural University, Ya'an, 625014 China.
authors: De
authors: Wu
authors: Key Laboratory for Animal Disease Resistance Nutrition of the Ministry of Education, Animal Nutrition Institute, Sichuan Agricultural University, Ya'an, 625014 China.
authors: Zhengfeng
authors: 0000-0003-1844-194X
authors: Z
authors: Fang
keywords: Energy metabolism; Intestine; Lactating sows; Methionine nutrition; Neonatal pigs