title: Cellular and Molecular Mechanisms of MT1-MMP-Dependent Cancer Cell Invasion.
abstract: Metastasis is responsible for most cancer-associated deaths. Accumulating evidence based on 3D migration models has revealed a diversity of invasive migratory schemes reflecting the plasticity of tumor cells to switch between proteolytic and nonproteolytic modes of invasion. Yet, initial stages of localized regional tumor dissemination require proteolytic remodeling of the extracellular matrix to overcome tissue barriers. Recent data indicate that surface-exposed membrane type 1-matrix metalloproteinase (MT1-MMP), belonging to a group of membrane-anchored MMPs, plays a central role in pericellular matrix degradation during basement membrane and interstitial tissue transmigration programs. In addition, a large body of work indicates that MT1-MMP is targeted to specialized actin-rich cell protrusions termed invadopodia, which are responsible for matrix degradation. This review describes the multistep assembly of actin-based invadopodia in molecular details. Mechanisms underlying MT1-MMP traffic to invadopodia through endocytosis/recycling cycles, which are key to the invasive program of carcinoma cells, are discussed.
authors: Cell Polarity, Migration and Cancer Unit, Institut Pasteur, Paris, F-75724 France.
authors: Antonio
authors: A
authors: Castro-Castro
authors: Imagine Institute of Genetic Diseases, Paris, F-75015 France.
authors: Valentina
authors: V
authors: Marchesin
authors: Barts Cancer Institute, University of London John Vane Science Centre, London EC1M 6BQ, United Kingdom.
authors: Pedro
authors: P
authors: Monteiro
authors: Instituto de Oncologia Ángel H. Roffo, Research Area, Buenos Aires, C1417DTB, Argentina.
authors: Catalina
authors: C
authors: Lodillinsky
authors: Institut Curie, Paris, F-75248 France; email: philippe.chavrier@curie.fr.|PSL Research University, Paris, F-75005 France.|CNRS, UMR 144, Paris, F-75248 France.
authors: Carine
authors: C
authors: Rossé
authors: Institut Curie, Paris, F-75248 France; email: philippe.chavrier@curie.fr.|PSL Research University, Paris, F-75005 France.|CNRS, UMR 144, Paris, F-75248 France.
authors: Philippe
authors: P
authors: Chavrier
mesh_terms: D000818:Animals; D016764:Cell Polarity; D006801:Humans; D053511:Matrix Metalloproteinase 14 / Q000378:metabolism*; D008954:Models, Biological; D009361:Neoplasm Invasiveness; D009369:Neoplasms / Q000201:enzymology* / Q000473:pathology*; D000069261:Podosomes / Q000378:metabolism
chemical_list: D053511:Matrix Metalloproteinase 14
keywords: MT1-MMP; actin; cancer; exocytosis; invadopodia; metastasis