title: Involvement of mast cells and microvessels density in reactive lesions of oral cavity: A comparative immunohistochemical study.
abstract: In view of the similarity of clinicopathological features between reactive lesions of the oral cavity, the objective of the present study was to investigate the density of MCs (mast cells) and microvessels in a series of these lesions. Thirty-seven cases of reactive lesions including fibrous hyperplasia (FH, n=10), inflammatory fibrous hyperplasia (IFH, n=10), peripheral giant cell lesion (PGCL, n=10) and lobular capillary hemangioma (LCH, n=7) were investigated using immunohistochemistry for mast cell tryptase and CD34. For comparative purposes, central giant cell lesions (CGCL, n=5) were included. A higher MC density was observed in LCH (37.01), while CGCL exhibited the lowest density (n=8.14). There was a significant difference in MC density when all reactive lesions were compared to CGCL (p=0.001). The largest mean density of microvessels was observed in LCH (n=21.69). The smallest number was observed in CGCL (n=6.24). There was a significant difference in microvessel density when the reactive lesions were compared to CGCL (p=0.003). There was a significant and direct correlation between the density of MCs and microvessels only for IFH (p=0.048) and CGCL (p=0.005). A significant and direct correlation between the mean density of MCs and microvessels was observed when the reactive lesions were analyzed as a whole (p=0.005). Our results suggest that mast cells contribute to the connective tissue framework and angiogenic function, as well as the development, of reactive lesions of the oral cavity, including FH, IFH, LCH and PGCL.
authors: Laboratory of Oral Surgical Pathology, School of Dentistry, Federal University of Bahia, Salvador, Bahia, Avenida Araújo Pinho, 62, Canela, Salvador, Bahia 40110-150, Brazil. Electronic address: stephanyferreira3@gmail.com.
authors: Stephany Vasco
authors: SV
authors: Ferreira
authors: Laboratory of Oral Surgical Pathology, School of Dentistry, Federal University of Bahia, Salvador, Bahia, Avenida Araújo Pinho, 62, Canela, Salvador, Bahia 40110-150, Brazil. Electronic address: f.calo@uol.com.br.
authors: Flávia Caló Aquino
authors: FC
authors: Xavier
authors: School of Dentistry, State University of Southwest Bahia, Jequié, Bahia, Brazil.
authors: Maria da Conceição Andrade de
authors: Mda C
authors: Freitas
authors: Laboratory of Molecular Pathology, School of Dentistry, University of São Paulo, Avenida Prof Lineu Prestes, 2227, Butantã, São Paulo, SP 05508-000, Brazil. Electronic address: fadnunes@usp.br.
authors: Fábio Daumas
authors: FD
authors: Nunes
authors: Laboratory of Oral Surgical Pathology, School of Dentistry, Federal University of Bahia, Salvador, Bahia, Avenida Araújo Pinho, 62, Canela, Salvador, Bahia 40110-150, Brazil. Electronic address: gurgel.clarissa@gmail.com.
authors: Clarissa Araújo
authors: CA
authors: Gurgel
authors: Department of Dental Public Health, School of Dentistry, Federal University of Bahia, Avenida Araújo Pinho, 62, Canela, Salvador, Bahia 40110-150, Brazil. Electronic address: cangussu@ufba.br.
authors: Maria Cristina Teixeira
authors: MC
authors: Cangussu
authors: Department of Oral Pahology, School of Dentistry, Federal University of Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil. Electronic address: manomartins@gmail.com.
authors: Manoela Domingues
authors: MD
authors: Martins
authors: Department of Health, School of Dentistry, State Universitiy of Feira de Santana, Feira de Santana, Bahia, Brazil. Electronic address: valeria.souza.freitas@gmail.com.
authors: Valéria Souza
authors: VS
authors: Freitas
authors: Laboratory of Oral Surgical Pathology, School of Dentistry, Federal University of Bahia, Salvador, Bahia, Avenida Araújo Pinho, 62, Canela, Salvador, Bahia 40110-150, Brazil. Electronic address: jeanunes@ufba.br.
authors: Jean Nunes
authors: JN
authors: Dos Santos
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002452:Cell Count; D005260:Female; D006101:Granuloma, Giant Cell / Q000378:metabolism / Q000473:pathology*; D017789:Granuloma, Pyogenic / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D006965:Hyperplasia / Q000378:metabolism / Q000473:pathology; D007150:Immunohistochemistry; D008297:Male; D008407:Mast Cells / Q000378:metabolism / Q000473:pathology*; D055806:Microvessels / Q000378:metabolism / Q000473:pathology*; D008875:Middle Aged; D009055:Mouth / Q000378:metabolism / Q000473:pathology*; D009059:Mouth Diseases / Q000378:metabolism / Q000473:pathology*; D009389:Neovascularization, Pathologic / Q000378:metabolism / Q000473:pathology; D055815:Young Adult
keywords: Angiogenesis; Mast cells; Oral reactive lesions