title: Molecular Pathology: Predictive, Prognostic, and Diagnostic Markers in Uterine Tumors.
abstract: This article focuses on the diagnostic, prognostic, and predictive molecular biomarkers in uterine malignancies, in the context of morphologic diagnoses. The histologic classification of endometrial carcinomas is reviewed first, followed by the description and molecular classification of endometrial epithelial malignancies in the context of histologic classification. Taken together, the molecular and histologic classifications help clinicians to approach troublesome areas encountered in clinical practice and evaluate the utility of molecular alterations in the diagnosis and subclassification of endometrial carcinomas. Putative prognostic markers are reviewed. The use of molecular alterations and surrogate immunohistochemistry as prognostic and predictive markers is also discussed.
authors: Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA.
authors: Lauren L
authors: LL
authors: Ritterhouse
authors: Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA. Electronic address: bhowitt@partners.org.
authors: Brooke E
authors: BE
authors: Howitt
mesh_terms: D014408:Biomarkers, Tumor; D018269:Carcinoma, Endometrioid / Q000175:diagnosis / Q000235:genetics / Q000473:pathology; D004252:DNA Mutational Analysis / Q000379:methods; D016889:Endometrial Neoplasms / Q000175:diagnosis / Q000235:genetics / Q000473:pathology; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D017404:In Situ Hybridization, Fluorescence; D057089:Pathology, Molecular; D011237:Predictive Value of Tests; D011379:Prognosis; D016159:Tumor Suppressor Protein p53; D014594:Uterine Neoplasms / Q000175:diagnosis* / Q000235:genetics / Q000473:pathology*
chemical_list: D014408:Biomarkers, Tumor; D016159:Tumor Suppressor Protein p53
keywords: Adenocarcinomas; Endometrial; Endometrioid; MSI; POLE; Serous