title: Experimental gender related obesity effect of diet.
abstract: BACKGROUND
  High-calorie diet is responsible for excessive weight gain. Obesity has recently become world epidemics, affecting not only adults but also children, which makes it the biggest health problem in the world. Yet the underlying mechanism remains a matter of debate.
  
  
  OBJECTIVE
  The aim of this study is to clarify the role of gender in high fat diet induced obesity in pups and adult animals.
  
  
  METHODS
  Female rats were fed low/ high fat diet during mating, pregnancy and lactation. The offspring and adult rats fed different diet had their body weight and temperature measurements taken twice a week. On the 21st day of the experiment the animals underwent anesthesia in order to have their blood samples collected for lipid profile.
  
  
  RESULTS
  After 3 weeks on HF diet female pups body weight was higher than in control group (p 〈0.05). Contrary to the female pups, the increase in body weight was higher (p 〈0.05) in male pups and occurred after 2 and 3 weeks. In adult female rats body weight increased after 2 weeks on HF, while in adult male group such weight gain was observed no sooner than after 3 weeks. A er three weeks of the experiment body weight was correlated positively (r = 0.941) with lipid profile of adult both gender groups on HF diet.
  
  
  CONCLUSIONS
  In male pups group body weight increased faster and achieved higher values then in female pups. On the contrary, in adult group of females body weight increased faster than in male rats and achieved similar values.
authors: Department of Pathophysiology, Jagiellonian University Medical College, Krakow, Poland. abaranowska@cm-uj.krakow.pl.
authors: Agnieszka
authors: A
authors: Baranowska
authors: Beata
authors: B
authors: Skowron
authors: Katarzyna
authors: K
authors: Ciesielczyk
authors: Justyna
authors: J
authors: Domagała
authors: Piotr J
authors: PJ
authors: Thor
mesh_terms: D000824:Animal Nutritional Physiological Phenomena; D000818:Animals; D000831:Animals, Newborn; D059305:Diet, High-Fat; D004435:Eating; D005260:Female; D008297:Male; D039382:Maternal Nutritional Physiological Phenomena; D009765:Obesity / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D015430:Weight Gain
keywords: high-fat diet; obesity; rat lipid profile