title: Biomimetic membrane-conjugated graphene nanoarchitecture for light-manipulating combined cancer treatment in vitro.
abstract: We report that through facile lipid self-assembly, biomimetic membrane-conjugated mesoporous silica-coated graphene oxide is constructed as targeting nanocarrier toward efficient combination of photothermal therapy and chemotherapy. Impressively, the simple surface modification with folate-contained lipid bilayer allows the graphene-based nanoarchitecture above to be selectively internalized by tumor cells overexpressing relevant receptors. Compared to pure drug, 7-fold doxorubicin is delivered into tumor cells by the nanoarchitecture. After cellular internalization, upon near infrared light illumination, graphene oxide in the nanoarchitecture can convert light energy into heat to kill cancer cells partially. Simultaneously, hyperthermia will drive rapid release of doxorubicin from the nanoarchitecture above to further cause the death of more cancer cells. Thus, integrated cancer treatment with higher efficacy is achieved in vitro compared to that of individual therapy.
authors: Beijing National Laboratory for Molecular Sciences, CAS Key Lab of Colloid, Interface and Chemical Thermodynamics, Institute of Chemistry, Chinese Academy of Sciences, ZhongGuanCun, North First Street 2, 100190 Beijing, China; University of Chinese Academy of Sciences, Beijing 100049, China.
authors: Chenchen
authors: C
authors: Qin
authors: Beijing National Laboratory for Molecular Sciences, CAS Key Lab of Colloid, Interface and Chemical Thermodynamics, Institute of Chemistry, Chinese Academy of Sciences, ZhongGuanCun, North First Street 2, 100190 Beijing, China; University of Chinese Academy of Sciences, Beijing 100049, China.
authors: Jinbo
authors: J
authors: Fei
authors: Beijing National Laboratory for Molecular Sciences, CAS Key Lab of Colloid, Interface and Chemical Thermodynamics, Institute of Chemistry, Chinese Academy of Sciences, ZhongGuanCun, North First Street 2, 100190 Beijing, China; University of Chinese Academy of Sciences, Beijing 100049, China.
authors: Peng
authors: P
authors: Cai
authors: Beijing National Laboratory for Molecular Sciences, CAS Key Lab of Colloid, Interface and Chemical Thermodynamics, Institute of Chemistry, Chinese Academy of Sciences, ZhongGuanCun, North First Street 2, 100190 Beijing, China; University of Chinese Academy of Sciences, Beijing 100049, China.
authors: Jie
authors: J
authors: Zhao
authors: Beijing National Laboratory for Molecular Sciences, CAS Key Lab of Colloid, Interface and Chemical Thermodynamics, Institute of Chemistry, Chinese Academy of Sciences, ZhongGuanCun, North First Street 2, 100190 Beijing, China; University of Chinese Academy of Sciences, Beijing 100049, China. Electronic address: jbli@iccas.ac.cn.
authors: Junbai
authors: J
authors: Li
mesh_terms: D000903:Antibiotics, Antineoplastic / Q000737:chemistry / Q000494:pharmacology; D040761:Biomimetic Materials / Q000138:chemical synthesis* / Q000494:pharmacology / Q000528:radiation effects; D016923:Cell Death / Q000187:drug effects / Q000528:radiation effects; D003131:Combined Modality Therapy; D004317:Doxorubicin / Q000737:chemistry / Q000494:pharmacology; D004337:Drug Carriers; D004339:Drug Compounding; D004705:Endocytosis; D058973:Folate Receptors, GPI-Anchored / Q000235:genetics / Q000378:metabolism; D005492:Folic Acid / Q000737:chemistry / Q000378:metabolism; D015870:Gene Expression; D006108:Graphite / Q000737:chemistry; D006367:HeLa Cells; D006801:Humans; D007259:Infrared Rays; D008051:Lipid Bilayers / Q000737:chemistry; D061986:MCF-7 Cells; D058726:Nanoconjugates / Q000737:chemistry* / Q000528:radiation effects / Q000648:ultrastructure; D010789:Phototherapy / Q000379:methods*; D012822:Silicon Dioxide / Q000737:chemistry
chemical_list: D000903:Antibiotics, Antineoplastic; D004337:Drug Carriers; D058973:Folate Receptors, GPI-Anchored; D008051:Lipid Bilayers; D058726:Nanoconjugates; D012822:Silicon Dioxide; D006108:Graphite; D004317:Doxorubicin; D005492:Folic Acid
keywords: Biomimetic membrane; Cancer therapy; Drug delivery; Graphene oxide