title: Pre-eclampsia and risk of infantile haemangioma.
abstract: BACKGROUND
  Infantile haemangioma is the most common tumour of infancy, but the association with pre-eclampsia is poorly understood.
  
  
  OBJECTIVE
  We determined the relationship between variants of pre-eclampsia and risk of infantile haemangioma.
  
  
  METHODS
  We carried out a retrospective cohort study of hospital data for all live births between 1989 and 2013 in Quebec, Canada. We identified 14 240 neonates with, and 1 930 564 without haemangioma before discharge, and determined whether early- or late-onset pre-eclampsia was documented on the maternal chart. We used log-binomial regression to compute prevalence ratios (PRs) and 95% confidence intervals (CIs) for the association between pre-eclampsia and infantile haemangioma, adjusted for maternal characteristics.
  
  
  RESULTS
  The prevalence of any haemangioma was higher for pre-eclampsia than for no pre-eclampsia (81·3 vs. 72·9 per 10 000), with a PR of 1·15 (95% CI 1·06-1·25) after adjustment for maternal characteristics. Pre-eclampsia with onset before 34 weeks' gestation was associated with cutaneous (PR 2·32, 95% CI 1·68-3·21), noncutaneous (PR 3·66, 95% CI 2·49-5·37) and unspecified haemangioma (PR 2·49, 95% CI 1·77-3·49). However, the association between early-onset pre-eclampsia and haemangioma was attenuated once long neonatal length of hospital stays was accounted for. There was no association with late-onset pre-eclampsia after 34 weeks, and associations were weaker for other variants including severe pre-eclampsia and pre-eclampsia with low birthweight.
  
  
  CONCLUSIONS
  Early-onset pre-eclampsia is associated with increased risk of haemangioma at birth, but detection bias due to longer hospital stays and closer follow-up may be part of the reason.
authors: University of Montreal Hospital Research Centre, Montreal, QC, Canada.|Institut national de santé publique du Québec, Montreal, QC, Canada.
authors: N
authors: http://orcid.org/0000-0002-2412-0459
authors: N
authors: Auger
authors: Department of Obstetrics and Gynecology, University of Sherbrooke, Sherbrooke, QC, Canada.
authors: W D
authors: WD
authors: Fraser
authors: Department of Medical Genetics, University of British Columbia, Vancouver, BC, Canada.
authors: L
authors: L
authors: Arbour
authors: University of Montreal Hospital Research Centre, Montreal, QC, Canada.|Institut national de santé publique du Québec, Montreal, QC, Canada.
authors: J
authors: J
authors: Healy-Profitós
authors: Department of Dermatology and Pediatrics, Medical College of Wisconsin, Milwaukee, WI, U.S.A.
authors: B A
authors: BA
authors: Drolet
mesh_terms: D000328:Adult; D005260:Female; D006391:Hemangioma / Q000453:epidemiology*; D006801:Humans; D007231:Infant, Newborn; D007902:Length of Stay; D008297:Male; D008423:Maternal Age; D011225:Pre-Eclampsia / Q000453:epidemiology*; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D015995:Prevalence; D011792:Quebec / Q000453:epidemiology; D012307:Risk Factors; D012959:Socioeconomic Factors