title: Cyanation of Phenol Derivatives with Aminoacetonitriles by Nickel Catalysis.
abstract: Generation of useful arylnitrile structures from simple aromatic feedstock chemicals represents a fundamentally important reaction in chemical synthesis. The first nickel-catalyzed cyanation of phenol derivatives with metal-free cyanating agents, aminoacetonitriles, is described. A nickel-based catalytic system consisting of a unique diphosphine ligand such as dcype or dcypt enables the cyanation of versatile phenol derivatives such as aryl carbamates and aryl pivalates. The use of aminoacetonitriles as a cyanating agent leads to an environmentally and easy-to-use method for arylnitrile synthesis.
authors: Institute of Transformative Bio-Molecules (WPI-ITbM) and Graduate School of Science, Nagoya University , Chikusa, Nagoya 464-8602, Japan.
authors: Ryosuke
authors: R
authors: Takise
authors: Institute of Transformative Bio-Molecules (WPI-ITbM) and Graduate School of Science, Nagoya University , Chikusa, Nagoya 464-8602, Japan.|JST, ERATO, Itami Molecular Nanocarbon Project, Nagoya University , Chikusa, Nagoya 464-8602, Japan.
authors: Kenichiro
authors: K
authors: Itami
authors: Department of Applied Chemistry, Waseda University , 3-4-1 Ohkubo, Shinjuku, Tokyo 169-8555, Japan.
authors: Junichiro
authors: J
authors: Yamaguchi