title: The Effect of Platform Switching on Periimplant Crevicular Fluid Content During Early Wound Healing.
abstract: OBJECTIVE
  The objective of this study was to investigate the soft tissue response and periimplant crevicular fluid (PICF) content around platform-switched (PS) and platform-matched (PM) implants during early healing.
  
  
  METHODS
  Nonsmokers treatment planned to receive a single implant in 2 quadrants were recruited. Two-stage implant placement protocol with 1 PM and 1 PS implant was implemented. Periimplant probing depths (PDs), modified sulcus bleeding index, and plaque indices were recorded, and PICF was collected at 1, 2, 4, and 6 weeks after abutment connection.
  
  
  RESULTS
  PD readings were higher at week 1 than at week 6 for both groups (P = 0.0005). PD was statistically deeper in PM than in PS at week 1 (P = 0.03). There was a time-dependent decrease in total PICF volume for both groups. This decrease was statistically significant for PS (P = 0.0005), with no differences between the 2 groups at any time (P > 0.05). The decrease observed in both PM and PS for PICF interleukin 6 and macrophage inflammatory protein-1β, and in PS for tumor necrosis factor-α (TNF-α) was statistically significant (P ≤ 0.03). TNF-α was statistically higher in PS than in PM at week 1 (P = 0.005).
  
  
  CONCLUSIONS
  Within the limits of this study, it seems that periimplant soft tissue response around PM and PS implants is mostly similar during the early healing period.
authors: *Clinical Professor, Division of Periodontology, College of Dentistry, The Ohio State University, Columbus, OH. †Clinical Assistant Professor, Department of Periodontotics, School of Dentistry, University of Texas, Houston, TX. ‡Senior Research Associate, Nationwide Children's Hospital, Columbus, OH. §Associate Professor, Department of Microbiology, Immunology and Cell Biology, School of Medicine, West Virginia University, Morgantown, WV. ¶Biostatistician II, Department of Biomedical Informatics, College of Medicine, The Ohio State University, Columbus, OH. ‖Professor, Division of Periodontology, College of Dentistry, The Ohio State University, Columbus, OH.
authors: Hua-Hong
authors: HH
authors: Chien
authors: Hsiu-Wan
authors: HW
authors: Meng
authors: Amy C
authors: AC
authors: Gross
authors: Timothy D
authors: TD
authors: Eubank
authors: Vedat O
authors: VO
authors: Yildiz
authors: Binnaz
authors: B
authors: Leblebicioglu
mesh_terms: D000328:Adult; D000368:Aged; D016207:Cytokines / Q000032:analysis; D059605:Dental Implant-Abutment Design / Q000009:adverse effects; D015921:Dental Implants / Q000009:adverse effects; D005260:Female; D005883:Gingival Crevicular Fluid / Q000737:chemistry*; D006801:Humans; D008297:Male; D008875:Middle Aged; D000072836:Surgical Wound / Q000503:physiopathology; D014945:Wound Healing / Q000502:physiology
chemical_list: D016207:Cytokines; D015921:Dental Implants