title: The Enzymology of Organic Transformations: A Survey of Name Reactions in Biological Systems.
abstract: Chemical reactions that are named in honor of their true, or at least perceived, discoverers are known as "name reactions". This Review is a collection of biological representatives of named chemical reactions. Emphasis is placed on reaction types and catalytic mechanisms that showcase both the chemical diversity in natural product biosynthesis as well as the parallels with synthetic organic chemistry. An attempt has been made, whenever possible, to describe the enzymatic mechanisms of catalysis within the context of their synthetic counterparts and to discuss the mechanistic hypotheses for those reactions that are currently active areas of investigation. This Review has been categorized by reaction type, for example condensation, nucleophilic addition, reduction and oxidation, substitution, carboxylation, radical-mediated, and rearrangements, which are subdivided by name reactions.
authors: Division of Chemical Biology and Medicinal Chemistry, College of Pharmacy, and Department of Chemistry, University of Texas at Austin, Austin, TX, 78731, USA.
authors: Chia-I
authors: CI
authors: Lin
authors: Division of Chemical Biology and Medicinal Chemistry, College of Pharmacy, and Department of Chemistry, University of Texas at Austin, Austin, TX, 78731, USA.
authors: Reid M
authors: RM
authors: McCarty
authors: Division of Chemical Biology and Medicinal Chemistry, College of Pharmacy, and Department of Chemistry, University of Texas at Austin, Austin, TX, 78731, USA.
authors: Hung-Wen
authors: 0000-0001-8953-4794
authors: HW
authors: Liu
mesh_terms: D000818:Animals; D001419:Bacteria / Q000737:chemistry / Q000201:enzymology / Q000378:metabolism; D055162:Biocatalysis; D001688:Biological Products / Q000737:chemistry* / Q000378:metabolism*; D053898:Biosynthetic Pathways; D003500:Cyclization; D005658:Fungi / Q000737:chemistry / Q000201:enzymology / Q000378:metabolism; D006801:Humans; D010084:Oxidation-Reduction; D010944:Plants / Q000737:chemistry / Q000201:enzymology / Q000378:metabolism; D013379:Substrate Specificity
chemical_list: D001688:Biological Products
keywords: biosynthesis; catalysis; enzymes; name reaction; reaction mechanisms