title: Cell division of Streptococcus pneumoniae: think positive!
abstract: Bacterial cell division is achieved by a dynamic protein complex called the divisome. The accurate placement of the divisome, and more specifically that of the tubulin-like protein FtsZ which forms the contractile Z-ring at mid-cell, is finely regulated by different mechanisms tailored to each bacterial class. To give rise to two viable daughter cells with the same genetic heritage and cell shape, Streptococcus pneumoniae uses an original system that relies on the membrane protein MapZ. This system is required for identifying the division site as well as positioning the Z-ring at mid-cell. In addition, MapZ undergoes phosphorylation by the serine/threonine kinase StkP and controls the constriction of the Z-ring. Here, we discuss recent advances and concepts of the MapZ system.
authors: CNRS, Molecular Microbiology and Structural Biochemistry, UMR 5086, 7 passage du Vercors, 69367 Lyon, France; Université Lyon 1, Molecular Microbiology and Structural Biochemistry, UMR 5086, 7 passage du Vercors, 69367 Lyon, France; Univ Lyon, Université Lyon 1, CNRS, UMR5558, Laboratoire de Biométrie et Biologie Evolutive, 43 bd du 11 novembre 1918, F-69622 Villeurbanne, France.
authors: Pierre Simon
authors: PS
authors: Garcia
authors: Université Grenoble Alpes, Institut de Biologie Structurale, 71 avenue des Martyrs - CS10090, 38044 Grenoble cedex 9, France; CEA, DSV, Institut de Biologie Structurale, 71 avenue des Martyrs - CS10090, 38044 Grenoble cedex 9, France; CNRS, Institut de Biologie Structurale, 71 avenue des Martyrs - CS10090, 38044 Grenoble cedex 9, France.
authors: Jean-Pierre
authors: JP
authors: Simorre
authors: Univ Lyon, Université Lyon 1, CNRS, UMR5558, Laboratoire de Biométrie et Biologie Evolutive, 43 bd du 11 novembre 1918, F-69622 Villeurbanne, France.
authors: Céline
authors: C
authors: Brochier-Armanet
authors: CNRS, Molecular Microbiology and Structural Biochemistry, UMR 5086, 7 passage du Vercors, 69367 Lyon, France; Université Lyon 1, Molecular Microbiology and Structural Biochemistry, UMR 5086, 7 passage du Vercors, 69367 Lyon, France. Electronic address: c.grangeasse@ibcp.fr.
authors: Christophe
authors: C
authors: Grangeasse
mesh_terms: D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism*; D002455:Cell Division; D003598:Cytoskeletal Proteins / Q000235:genetics / Q000378:metabolism; D010766:Phosphorylation; D011485:Protein Binding; D013296:Streptococcus pneumoniae / Q000166:cytology* / Q000235:genetics / Q000254:growth & development / Q000378:metabolism*
chemical_list: D001426:Bacterial Proteins; D003598:Cytoskeletal Proteins; C071525:FtsZ protein, Bacteria