title: Adult Onset of Xanthelasmoid Mastocytosis: Report of a Rare Entity.
abstract: Xanthelasmoid or pseudoxanthomatous mastocytosis is an extremely rare variant of diffuse cutaneous mastocytosis. Herein, we describe an adult male with cutaneous mastocytosis showing multiple widespread yellowish ovoid papules like eruptive xanthoma. A 60-year-old male visited our outpatient clinic with a 1-year history of generalized yellowish, ovoid, and skin color papular eruption located on the trunk, groin, extremities, with the modest pruritus. Vital signs were stable, and Darier's sign was negative. No other subjective and objective signs were detected during the examination. No abnormality was detected in his diagnostic laboratory tests. Skin biopsy was taken, and histopathologic examination revealed proliferation of mast cells with ovoid and spindle nuclei with distinct cytoplasm borders around the capillaries, which was compatible with mastocytosis. Antihistamine was prescribed for pruritus control which was successful, but eruptions were persistent, and even 1-year phototherapy was not useful.
authors: Department of Dermatology, Cutaneous Leishmaniasis Research Center, Quaem Hospital, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
authors: Nafiseh Sadat
authors: NS
authors: Nabavi
authors: Department of Dermatology, Cutaneous Leishmaniasis Research Center, Quaem Hospital, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
authors: Masumeh Hosseini
authors: MH
authors: Nejad
authors: Department of Dermatology, Cutaneous Leishmaniasis Research Center, Quaem Hospital, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
authors: Shahab
authors: S
authors: Feli
authors: Department of Dermatology, Cutaneous Leishmaniasis Research Center, Quaem Hospital, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
authors: Behnoosh
authors: B
authors: Bakhshoodeh
authors: Department of Dermatology, Cutaneous Leishmaniasis Research Center, Quaem Hospital, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
authors: Pouran
authors: P
authors: Layegh
keywords: Adult; mastocytosis; pseudoxanthomatous; xanthelasmoid