title: Plasma Inflammatory Cytokine IL-4, IL-8, IL-10, and TNF-α Levels Correlate with Pulmonary Function in Patients with Asthma-Chronic Obstructive Pulmonary Disease (COPD) Overlap Syndrome.
abstract: BACKGROUND The aim of this study was to investigate the plasma inflammatory cytokine levels and their correlations with pulmonary function in patients with asthma-chronic obstructive pulmonary disease overlap syndrome (ACOS). MATERIAL AND METHODS Between January 2013 and December 2014, a total of 96 patients with asthma, acute exacerbation of chronic obstructive pulmonary disease (AECOPD), or ACOS were enrolled, and 35 healthy people were included as a control group. Fasting plasma interleukin (IL)-4, IL-8, IL-10, and tumor necrosis factor alpha (TNF-α) levels were detected using enzyme-linked immunosorbent assay (ELISA). Correlations between the plasma inflammatory cytokine levels and forced expiratory volume in 1 second (FEV1), FEV1/predicted value ratio (FEV1%pred), and FEV1/forced vital capacity (FVC) were analyzed. RESULTS IL-4 and IL-8 levels showed statistically significant differences among the 3 groups of patients (both P<0.001); IL-4 level was significantly lower, while IL-8 level was significantly higher in the AECOPD group and ACOS group than those in the asthma group (all P<0.05). IL-10 level and TNF-α level were significantly different among the 3 patient groups (both P<0.001). IL-10 level was significantly different between each of the 2 groups (all P<0.001). TNF-α level in the asthma group was higher than in the AECOPD group and ACOS group (both P<0.001). IL-4 and IL-10 were positively and IL-8 and TNF-α were negatively related with FEV1, FEV1%pred, and FEV1/FVC. CONCLUSIONS Plasma levels of inflammatory cytokines IL-4, IL-8, IL-10, and TNF-α are related with severity of airway diseases and could be potential markers for the evaluation of asthma, COPD, and ACOS.
authors: Department of Respiratory Medicine, The First Affiliated Hospital of Nanjing Medical University Nanjing, Jiangsu, China (mainland)
authors: Ai-Xia
authors: AX
authors: Huang
authors: Department of Respiratory Medicine, South Campus, Shanghai Jiaotong University 6th Hospital, Shanghai, China (mainland)
authors: Li-Wen
authors: LW
authors: Lu
authors: Department of Respiratory Medicine, South Campus, Shanghai Jiaotong University 6th Hospital, Shanghai, China (mainland)
authors: Wen-Juan
authors: WJ
authors: Liu
authors: Department of Respiratory Medicine, The First Affiliated Hospital of Nanjing Medical University Nanjing, Jiangsu, China (mainland)
authors: Mao
authors: M
authors: Huang
mesh_terms: D000328:Adult; D000368:Aged; D001249:Asthma / Q000097:blood* / Q000235:genetics / Q000276:immunology / Q000503:physiopathology; D016022:Case-Control Studies; D002681:China; D016207:Cytokines / Q000097:blood; D005260:Female; D005541:Forced Expiratory Volume; D006801:Humans; D007378:Interleukins / Q000097:blood*; D008168:Lung / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D029424:Pulmonary Disease, Chronic Obstructive / Q000097:blood* / Q000235:genetics / Q000276:immunology / Q000503:physiopathology; D012129:Respiratory Function Tests; D013577:Syndrome; D014409:Tumor Necrosis Factor-alpha / Q000097:blood*
chemical_list: D016207:Cytokines; D007378:Interleukins; D014409:Tumor Necrosis Factor-alpha