title: Genetic/Familial High-Risk Assessment: Colorectal Version 1.2016, NCCN Clinical Practice Guidelines in Oncology.
abstract: This is a focused update highlighting the most current NCCN Guidelines for diagnosis and management of Lynch syndrome. Lynch syndrome is the most common cause of hereditary colorectal cancer, usually resulting from a germline mutation in 1 of 4 DNA mismatch repair genes (MLH1, MSH2, MSH6, or PMS2), or deletions in the EPCAM promoter. Patients with Lynch syndrome are at an increased lifetime risk, compared with the general population, for colorectal cancer, endometrial cancer, and other cancers, including of the stomach and ovary. As of 2016, the panel recommends screening all patients with colorectal cancer for Lynch syndrome and provides recommendations for surveillance for early detection and prevention of Lynch syndrome-associated cancers.
authors: Dawn
authors: D
authors: Provenzale
authors: Samir
authors: S
authors: Gupta
authors: Dennis J
authors: DJ
authors: Ahnen
authors: Travis
authors: T
authors: Bray
authors: Jamie A
authors: JA
authors: Cannon
authors: Gregory
authors: G
authors: Cooper
authors: Donald S
authors: DS
authors: David
authors: Dayna S
authors: DS
authors: Early
authors: Deborah
authors: D
authors: Erwin
authors: James M
authors: JM
authors: Ford
authors: Francis M
authors: FM
authors: Giardiello
authors: William
authors: W
authors: Grady
authors: Amy L
authors: AL
authors: Halverson
authors: Stanley R
authors: SR
authors: Hamilton
authors: Heather
authors: H
authors: Hampel
authors: Mohammad K
authors: MK
authors: Ismail
authors: Jason B
authors: JB
authors: Klapman
authors: David W
authors: DW
authors: Larson
authors: Audrey J
authors: AJ
authors: Lazenby
authors: Patrick M
authors: PM
authors: Lynch
authors: Robert J
authors: RJ
authors: Mayer
authors: Reid M
authors: RM
authors: Ness
authors: Scott E
authors: SE
authors: Regenbogen
authors: Niloy Jewel
authors: NJ
authors: Samadder
authors: Moshe
authors: M
authors: Shike
authors: Gideon
authors: G
authors: Steinbach
authors: David
authors: D
authors: Weinberg
authors: Mary
authors: M
authors: Dwyer
authors: Susan
authors: S
authors: Darlow
mesh_terms: D015179:Colorectal Neoplasms / Q000175:diagnosis / Q000453:epidemiology / Q000235:genetics / Q000628:therapy; D003123:Colorectal Neoplasms, Hereditary Nonpolyposis / Q000175:diagnosis* / Q000453:epidemiology / Q000235:genetics / Q000628:therapy*; D019468:Disease Management; D055088:Early Detection of Cancer / Q000379:methods; D018095:Germ-Line Mutation; D006801:Humans; D011159:Population Surveillance; D018570:Risk Assessment