title: Development of a novel linearly-filled Derenzo microPET phantom.
abstract: Positron emission tomography (PET) phantoms are used to calibrate PET scanners so that inter-scanner and inter-isotope comparison can be made between PET datasets. Hot rod style phantoms have a hole pattern, which is filled with a positron-emitting isotope and typically involves using two radioisotope reservoirs with the pattern created with channels in between. However, this configuration is difficult to fill and requires an excess of activity and volume. Here we present an alternative design, a phantom that is linearly filled-one channel at a time. The process of fabrication of prototypes of the design is described and PET images of the prototyped phantom are also shown for a variety of commonly used radioisotopes ((52)Mn, (64)Cu, (76)Br, (124)I). This design allows for a large reduction in isotope volume and required filling time making a quality assurance (QA) protocol safer, more efficient and less costly.
authors: Department of Medical Physics, University of WisconsinMadison, WI, USA; Medical Engineering Group, Morgridge Institute for ResearchMadison, WI, USA.
authors: Benjamin L
authors: BL
authors: Cox
authors: Department of Medical Physics, University of Wisconsin Madison, WI, USA.
authors: Stephen A
authors: SA
authors: Graves
authors: SOFIE Biosciences Los Angeles, CA, USA.
authors: Mohammed
authors: M
authors: Farhoud
authors: Department of Medical Physics, University of Wisconsin Madison, WI, USA.
authors: Todd E
authors: TE
authors: Barnhart
authors: UW Carbone Cancer Center Madison, WI, USA.
authors: Justin J
authors: JJ
authors: Jeffery
authors: Department of Medical Physics, University of WisconsinMadison, WI, USA; Medical Engineering Group, Morgridge Institute for ResearchMadison, WI, USA; UW Carbone Cancer CenterMadison, WI, USA.
authors: Kevin W
authors: KW
authors: Eliceiri
authors: Department of Medical Physics, University of Wisconsin Madison, WI, USA.
authors: Robert J
authors: RJ
authors: Nickles
keywords: 3D printing; Derenzo phantom; Positron emission tomography (PET); hot-rod Derenzo; microPET; quality control (QC); rresolution