title: Efficiency of mild ovarian stimulation with clomiphene on poor ovarian responders during IVF\ICSI procedures: a meta-analysis.
abstract: OBJECTIVE
  Our study aims to provide evidence for evaluating the efficiency of mild controlled ovarian hyperstimulation (COH) protocol with clomiphene citrate on ovarian stimulation outcome and pregnancy outcome on poor ovarian respond patients undergoing in vitro fertilization treatment.
  
  
  METHODS
  For the current study, a search was carried out for relevant randomized controlled trials (RCTs). This meta-analysis was performed on both COH and pregnancy outcomes following the mild COH protocols (CC/Gn/GnRH antagonist) and conventional COH protocols (Gn/GnRH agonist). Outcomes in our analysis were measured in terms of odd ratios (ORs) with 95% confidence intervals (CI) using random effect models or fixed effect models.
  
  
  RESULTS
  Four RCTs were finally selected to perform this meta-analysis. Our meta-analysis indicated that there was no significant difference for live birth rate (OR: 0.71, 95% CI 0.22-2.29, P=0.57) and clinical pregnancy rate (OR: 1.11, 95% CI 0.80-1.55, P=0.52) for these two COH protocols. A significant heterogeneity was found when meta-analysis was performed on outcomes such as oocytes retrieved numbers, endometrium thickness, and the cancelled cycles.
  
  
  CONCLUSIONS
  This meta-analysis suggested that mild COH protocol with CC may obtain equal pregnancy outcome on POR patients undergoing IVF treatment compared with that of the conventional COH protocol.
authors: Center for Reproduction and Genetics, Suzhou Municipal Hospital, Nanjing Medical University Affiliated Suzhou Hospital, Suzhou, Jiangsu 215002, China.
authors: Dan
authors: D
authors: Song
authors: Center for Reproduction and Genetics, Suzhou Municipal Hospital, Nanjing Medical University Affiliated Suzhou Hospital, Suzhou, Jiangsu 215002, China.
authors: Yichao
authors: Y
authors: Shi
authors: Center for Reproduction and Genetics, Suzhou Municipal Hospital, Nanjing Medical University Affiliated Suzhou Hospital, Suzhou, Jiangsu 215002, China.
authors: Yun
authors: Y
authors: Zhong
authors: Center for Reproduction and Genetics, Suzhou Municipal Hospital, Nanjing Medical University Affiliated Suzhou Hospital, Suzhou, Jiangsu 215002, China.
authors: Qingxia
authors: Q
authors: Meng
authors: Department of Gynecology, Suzhou Municipal Hospital, Nanjing Medical University Affiliated Suzhou Hospital, Suzhou, Jiangsu 215002, China.
authors: Shunyu
authors: S
authors: Hou
authors: Center for Reproduction and Genetics, Suzhou Municipal Hospital, Nanjing Medical University Affiliated Suzhou Hospital, Suzhou, Jiangsu 215002, China. Electronic address: hongliszivf@163.com.
authors: Hong
authors: H
authors: Li
mesh_terms: D005260:Female; D005307:Fertilization in Vitro / Q000379:methods*; D006801:Humans; D010062:Ovulation Induction / Q000379:methods*; D011247:Pregnancy; D011256:Pregnancy Outcome; D018873:Pregnancy Rate; D020554:Sperm Injections, Intracytoplasmic / Q000379:methods*; D016896:Treatment Outcome
keywords: Clomiphene citrate; Controlled ovarian hyperstimulation; In vitro fertilization; Mild stimulation