title: Functional brain networks underlying latent inhibition of conditioned disgust in rats.
abstract: The present experiment examined the neuronal networks involved in the latent inhibition of conditioned disgust by measuring brain oxidative metabolism. Rats were given nonreinforced intraoral (IO) exposure to saccharin (exposed groups) or water (non-exposed groups) followed by a conditioning trial in which the animals received an infusion of saccharin paired (or unpaired) with LiCl. On testing, taste reactivity responses displayed by the rats during the infusion of the saccharin were examined. Behavioral data showed that preexposure to saccharin attenuated the development of LiCl-induced conditioned disgust reactions, indicating that the effects of taste aversion on hedonic taste reactivity had been reduced. With respect to cumulative oxidative metabolic activity across the whole study period, the parabrachial nucleus was the only single region examined which showed differential activity between groups which received saccharin-LiCl pairings with and without prior non-reinforced saccharin exposure, suggesting a key role in the effects of latent inhibition of taste aversion learning. In addition, many functional connections between brain regions were revealed through correlational analysis of metabolic activity, in particular an accumbens-amygdala interaction that may be involved in both positive and negative hedonic responses.
authors: Department of Psychology, University of Oviedo, Oviedo, Spain; School of Psychology, Cardiff University, UK. Electronic address: gasallacantop@cardiff.ac.uk.
authors: Patricia
authors: P
authors: Gasalla
authors: Department of Psychology, University of Oviedo, Oviedo, Spain.
authors: Azucena
authors: A
authors: Begega
authors: Department of Psychology, University of Oviedo, Oviedo, Spain.
authors: Alberto
authors: A
authors: Soto
authors: School of Psychology, Cardiff University, UK.
authors: Dominic Michael
authors: DM
authors: Dwyer
authors: Department of Psychology, University of Oviedo, Oviedo, Spain.
authors: Matías
authors: M
authors: López
mesh_terms: D000818:Animals; D001362:Avoidance Learning / Q000502:physiology*; D001921:Brain / Q000201:enzymology*; D003214:Conditioning, Classical / Q000502:physiology*; D003576:Electron Transport Complex IV / Q000378:metabolism*; D007266:Inhibition, Psychological; D018021:Lithium Chloride / Q000009:adverse effects; D008297:Male; D009434:Neural Pathways / Q000502:physiology*; D051381:Rats; D017208:Rats, Wistar; D012439:Saccharin / Q000008:administration & dosage; D013649:Taste
chemical_list: D003576:Electron Transport Complex IV; D012439:Saccharin; D018021:Lithium Chloride
keywords: Conditioned disgust; Cytochrome oxidase; Latent inhibition; Taste aversion; Taste reactivity