title: Characteristics, Properties and Analytical Methods of Cefadroxil: A Review.
abstract: Infections are the second leading cause of mortality worldwide and there are many reasons justifying the need for further studies of antimicrobial agents. Cefadroxil is a drug that has bactericidal activity and broad spectrum of action. Quantitative analyzes about cefadroxil are essential for the understanding of bioavailability, bioequivalence, and therapeutic control, which will ensure the product's characteristics and patients' safety. Thus, this study highlights a brief literature review about the drug and the existing methods developed for the determination of cefadroxil found in official and scientific papers. According to the methods found in literature, liquid chromatography and spectrophotometry of absorption in the ultraviolet region prevailed over the others. Importantly, most of the solvents used for the development of the described analytical methods are toxic to the environment, making it necessary to educate researchers and pharmaceutical companies to use nontoxic solvents to provide environmental-friendly methods and better benefits to equipments and mainly to analysts.
authors: a Department of Drugs and Medicines , School of Pharmaceutical Sciences, São Paulo State University , Araraquara , SP , Brazil.
authors: Bianca Aparecida
authors: BA
authors: de Marco
authors: a Department of Drugs and Medicines , School of Pharmaceutical Sciences, São Paulo State University , Araraquara , SP , Brazil.
authors: Hérida Regina Nunes
authors: HR
authors: Salgado
mesh_terms: D002434:Cefadroxil / Q000032:analysis*; D002851:Chromatography, High Pressure Liquid; D015394:Molecular Structure; D013056:Spectrophotometry, Ultraviolet; D053719:Tandem Mass Spectrometry
chemical_list: D002434:Cefadroxil
keywords: Absorption spectrophotometry in the ultraviolet region; cefadroxil; high-performance liquid chromatography