title: Atherosclerotic Surrogate Markers in Adults With Down Syndrome: A Case-Control Study.
abstract: The authors aimed to compare surrogate markers of atherosclerosis (pulse wave velocity, intima-media thickness) between adults with and without Down syndrome (DS) and to assess the impact of parathyroid hormone levels and classic cardiovascular risk factors on arterial stiffness. After comparing 51 adults with DS and 51 healthy adults (siblings of DS individuals), the authors found that adults with DS seem to have lower arterial stiffness, as a result of chronic hypotension. Subclinical atherosclerosis parameters do not correlate with traditional cardiovascular risk factors in adults with DS, thus raising the hypothesis that classic predictive models for cardiovascular disease are not valid in this population. Hyperparathyroidism could play an important role in arterial damage in these individuals. The lower than expected prevalence of obesity and dyslipidemia could be explained by better eating habits, with this study being the first to address the anthropometric and clinical profile of a Mediterranean cohort of adults with DS.
authors: Adult Down Syndrome Outpatient Unit, Department of Internal Medicine, Fundación de Investigación Biomédica, Hospital Universitario de La Princesa, Madrid, Spain.
authors: Pedro
authors: http://orcid.org/0000-0002-6914-9693
authors: P
authors: Parra
authors: Adult Down Syndrome Outpatient Unit, Department of Internal Medicine, Fundación de Investigación Biomédica, Hospital Universitario de La Princesa, Madrid, Spain.
authors: Ramón
authors: R
authors: Costa
authors: Adult Down Syndrome Outpatient Unit, Department of Internal Medicine, Fundación de Investigación Biomédica, Hospital Universitario de La Princesa, Madrid, Spain.
authors: Diego Real
authors: DR
authors: de Asúa
authors: Adult Down Syndrome Outpatient Unit, Department of Internal Medicine, Fundación de Investigación Biomédica, Hospital Universitario de La Princesa, Madrid, Spain.
authors: Fernando
authors: F
authors: Moldenhauer
authors: Adult Down Syndrome Outpatient Unit, Department of Internal Medicine, Fundación de Investigación Biomédica, Hospital Universitario de La Princesa, Madrid, Spain.
authors: Carmen
authors: C
authors: Suárez
mesh_terms: D000328:Adult; D050197:Atherosclerosis / Q000175:diagnosis*; D059168:Carotid Intima-Media Thickness; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D004314:Down Syndrome / Q000150:complications* / Q000503:physiopathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D063177:Pulse Wave Analysis; D055815:Young Adult