title: Medical therapy to prevent recurrence of ventricular arrhythmia in normal and structural heart disease patients.
abstract: Recurrent ventricular arrhythmias (VA) are a source of significant morbidity in patients without structural heart disease (SHD) and also mortality in patients with SHD. The treatment goals for these two patient populations differ greatly. Areas covered: The secondary prevention of recurrent VA in patients without and with SHD will be reviewed, focusing on clinical data (especially randomized, controlled trials) in the literature as determined through searches in PubMed and ClinicalTrials.gov. This will include β blockers, non-dihydropyridine calcium channel blockers and antiarrhythmic drugs in both subgroups and non-antiarrhythmic medications in SHD. Expert commentary: The available options for medical therapy for VA in both normal hearts and SHD are insufficient, due to substandard efficacy and toxicities. While non-pharmacologic therapies may provide an excellent option, further drug development and randomized trials are needed, as is a reappraisal of the current mode of utilization.
authors: a Division of Cardiology, Department of Medicine, Westchester Medical Center , New York Medical College , Valhalla , NY , USA.
authors: Jason T
authors: JT
authors: Jacobson
authors: a Division of Cardiology, Department of Medicine, Westchester Medical Center , New York Medical College , Valhalla , NY , USA.
authors: Sei
authors: S
authors: Iwai
authors: a Division of Cardiology, Department of Medicine, Westchester Medical Center , New York Medical College , Valhalla , NY , USA.
authors: Wilbert
authors: W
authors: Aronow
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use*; D000889:Anti-Arrhythmia Agents / Q000627:therapeutic use*; D001145:Arrhythmias, Cardiac / Q000188:drug therapy / Q000209:etiology / Q000628:therapy*; D002121:Calcium Channel Blockers / Q000627:therapeutic use*; D002317:Cardiovascular Agents / Q000627:therapeutic use; D017115:Catheter Ablation; D006331:Heart Diseases / Q000150:complications; D006801:Humans; D016032:Randomized Controlled Trials as Topic; D012008:Recurrence; D017180:Tachycardia, Ventricular / Q000188:drug therapy / Q000209:etiology / Q000628:therapy; D014693:Ventricular Fibrillation / Q000188:drug therapy / Q000209:etiology / Q000628:therapy; D018879:Ventricular Premature Complexes / Q000188:drug therapy / Q000209:etiology / Q000628:therapy
chemical_list: D000319:Adrenergic beta-Antagonists; D000889:Anti-Arrhythmia Agents; D002121:Calcium Channel Blockers; D002317:Cardiovascular Agents
keywords: Ventricular tachycardia; antiarrhythmic drugs; cardiomyopathy; idiopathic; premature ventricular contractions; ventricular fibrillation