title: Ingenol Mebutate for Recalcitrant Chronic Actinic Cheilitis.
abstract: We present the case of a healthy 76-year-old man with a whitish, hyperkeratotic lesion of the lower lip diagnosed as actinic cheilitis (AC) previously treated with classic red light photodynamic therapy 5 years ago. Initial treatment with 5% imiquimod cream - also with intensified application - failed. After 2 cycles thrice daily, consecutive applications of 150 μg/g ingenol mebutate gel at 3 weeks' interval, the lesions cleared completely. Surprisingly, no pustular or crusting reaction or other side effect occurred contrary to expectation. Remission was stable for 10 months, when recurrence occurred. Ingenol mebutate proved to be a feasible and safe treatment in this otherwise refractory case of AC.
authors: Division of Dermatology and Venereology, Geneva University Hospitals, Geneva, Switzerland.
authors: Evangelia
authors: E
authors: Tzika
authors: Isabelle
authors: I
authors: Masouyé
authors: Michael
authors: M
authors: Mühlstädt
authors: Emmanuel
authors: E
authors: Laffitte
mesh_terms: D000279:Administration, Cutaneous; D000368:Aged; D000970:Antineoplastic Agents / Q000008:administration & dosage*; D002613:Cheilitis / Q000188:drug therapy*; D002908:Chronic Disease; D004224:Diterpenes / Q000008:administration & dosage*; D006801:Humans; D008046:Lip; D008048:Lip Neoplasms / Q000188:drug therapy*; D008297:Male; D009364:Neoplasm Recurrence, Local / Q000188:drug therapy*; D011230:Precancerous Conditions / Q000188:drug therapy; D012878:Skin Neoplasms / Q000188:drug therapy*
chemical_list: C486592:3-ingenyl angelate; D000970:Antineoplastic Agents; D004224:Diterpenes