title: Role of TRP channels in the induction of heat shock proteins (Hsps) by heating skin.
abstract: Transient receptor potential (TRP) channels in skin are crucial for achieving temperature sensitivity to maintain internal temperature balance and thermal homeostasis, as well as to protect skin cells from environmental stresses such as infrared (IR) or near-infrared (NIR) radiation via heat shock protein (Hsp) production. However, the mechanisms by which IR and NIR activate TRP channels and produce Hsps intracellularly have been independently reported. In this review, we discuss the relationship between TRP channel activation and Hsp production, and introduce the roles of several skin TRP channels in the regulation of HSP production by IR and NIR exposure.
authors: Graduate Institute of Medicine, School of Medicine, Kaohsiung Medical University, 100, Shih-Chuan 1st Road, Kaohsiung 80708, Taiwan; The Institute of Basic Medical Sciences, National Cheng Kung University Medical College, 1 University Road, Tainan 70101, Taiwan.
authors: Wen-Li
authors: WL
authors: Hsu
authors: Graduate Institute of Medicine, School of Medicine, Kaohsiung Medical University, 100, Shih-Chuan 1st Road, Kaohsiung 80708, Taiwan.
authors: Tohru
authors: T
authors: Yoshioka
keywords: Heat shock protein; TRP channel; infrared; near infrared; skin