title: Ion Channels in Endothelial Responses to Fluid Shear Stress.
abstract: Fluid shear stress is an important environmental cue that governs vascular physiology and pathology, but the molecular mechanisms that mediate endothelial responses to flow are only partially understood. Gating of ion channels by flow is one mechanism that may underlie many of the known responses. Here, we review the literature on endothelial ion channels whose activity is modulated by flow with an eye toward identifying important questions for future research.
authors: Department of Internal Medicine (Cardiology), Yale Cardiovascular Research Center, Yale University, New Haven, Connecticut; and.
authors: Kristin A
authors: KA
authors: Gerhold
authors: Department of Internal Medicine (Cardiology), Yale Cardiovascular Research Center, Yale University, New Haven, Connecticut; and Departments of Cell Biology and Biomedical Engineering, Yale University, New Haven, Connecticut martin.schwartz@yale.edu.
authors: Martin A
authors: MA
authors: Schwartz
mesh_terms: D000818:Animals; D015220:Calcium Channels / Q000502:physiology; D018118:Chloride Channels / Q000502:physiology; D042783:Endothelial Cells / Q000378:metabolism / Q000502:physiology*; D006801:Humans; D057446:Hydrodynamics; D015640:Ion Channel Gating; D007473:Ion Channels / Q000378:metabolism / Q000502:physiology*; D051379:Mice; D015221:Potassium Channels / Q000502:physiology; D015398:Signal Transduction; D015222:Sodium Channels / Q000502:physiology; D013312:Stress, Physiological
chemical_list: D015220:Calcium Channels; D018118:Chloride Channels; D007473:Ion Channels; D015221:Potassium Channels; D015222:Sodium Channels