title: Brown and Beige Adipose Tissue: Therapy for Obesity and Its Comorbidities?
abstract: Overweight and obesity are global health problems placing an ever-increasing demand on health care systems. Brown adipose tissue (BAT) is present in significant amounts in adults. BAT has potential as a fuel for oxidation and dissipation as heat production, which makes it an attractive target for obesity therapy. BAT activation results in increased energy expenditure via thermogenesis. The role of BAT/beige adipocyte activation on whole body energy homeostasis, body weight management/regulation, and whole body glucose and lipid homeostasis remains unproven. This paper reviews knowledge on brown/beige adipocytes in energy expenditure and how it may impact obesity therapy and its comorbidities.
authors: Department of Pathobiology, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Avenue, NE40, Cleveland, OH 44195, USA.
authors: Anny
authors: A
authors: Mulya
authors: Department of Pathobiology, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Avenue, NE40, Cleveland, OH 44195, USA; Department of Nutrition, School of Medicine, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106, USA; Metabolic Translational Research Center, Endocrine and Metabolism Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA. Electronic address: kirwanj@ccf.org.
authors: John P
authors: JP
authors: Kirwan
mesh_terms: D000069796:Adipose Tissue, Beige / Q000502:physiology*; D002001:Adipose Tissue, Brown / Q000502:physiology*; D015897:Comorbidity; D004734:Energy Metabolism; D006706:Homeostasis; D006801:Humans; D009765:Obesity / Q000628:therapy*; D022722:Thermogenesis
keywords: Beige adipose tissue; Brown adipose tissue; Energy expenditure; Lifestyle intervention; Obesity; Thermogenesis; Type 2 diabetes