title: Future prospects of antibacterial metal nanoparticles as enzyme inhibitor.
abstract: Nanoparticles are being widely used as antibacterial agents with metal nanoparticles emerging as the most efficient antibacterial agents. There have been many studies which have reported the mechanism of antibacterial activity of nanoparticles on bacteria. In this review we aim to emphasize on all the possible mechanisms which are involved in the antibacterial activity of nanoparticles and also to understand their mode of action and role as bacterial enzyme inhibitor by comparing their antibacterial mechanism to that of antibiotics with enzyme inhibition as a major mechanism. With the emergence of widespread antibiotic resistance, nanoparticles offer a better alternative to our conventional arsenal of antibiotics. Once the biological safety of these nanoparticles is addressed, these nanoparticles can be of great medical importance in our fight against bacterial infections.
authors: School of Chemical and Biotechnology, SASTRA University, Thanjavur 613 401, Tamil Nadu, India.
authors: Khan Behlol Ayaz
authors: KBA
authors: Ahmed
authors: School of Chemical and Biotechnology, SASTRA University, Thanjavur 613 401, Tamil Nadu, India. Electronic address: raman@biotech.sastra.edu.
authors: Thiagarajan
authors: T
authors: Raman
authors: School of Chemical and Biotechnology, SASTRA University, Thanjavur 613 401, Tamil Nadu, India. Electronic address: anbazhagan@scbt.sastra.edu.
authors: Anbazhagan
authors: A
authors: Veerappan
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000627:therapeutic use; D001419:Bacteria / Q000201:enzymology*; D001424:Bacterial Infections / Q000188:drug therapy* / Q000201:enzymology; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000627:therapeutic use; D006801:Humans; D053768:Metal Nanoparticles / Q000737:chemistry*
chemical_list: D000900:Anti-Bacterial Agents; D004791:Enzyme Inhibitors
keywords: Antibacterial activity; Enzyme inhibitors; Metal nanoparticles; Nanoparticles