title: Inflammation Thread Runs across Medical Laboratory Specialities.
abstract: We work on the assumption that four major specialities or sectors of medical laboratory assays, comprising clinical chemistry, haematology, immunology, and microbiology, embraced by genome sequencing techniques, are routinely in use. Medical laboratory markers for inflammation serve as model: they are allotted to most fields of medical lab assays including genomics. Incessant coding of assays aligns each of them in the long lists of big data. As exemplified with the complement gene family, containing C2, C3, C8A, C8B, CFH, CFI, and ITGB2, heritability patterns/risk factors associated with diseases with genetic glitch of complement components are unfolding. The C4 component serum levels depend on sufficient vitamin D whilst low vitamin D is inversely related to IgG1, IgA, and C3 linking vitamin sufficiency to innate immunity. Whole genome sequencing of microbial organisms may distinguish virulent from nonvirulent and antibiotic resistant from nonresistant varieties of the same species and thus can be listed in personal big data banks including microbiological pathology; the big data warehouse continues to grow.
authors: Labormedizinisches Zentrum Dr. Risch and Kantonsspital Graubünden, 7000 Chur, Switzerland.
authors: Urs
authors: 0000-0002-2584-5873
authors: U
authors: Nydegger
authors: Labormedizinisches Zentrum Dr. Risch and Kantonsspital Graubünden, 7000 Chur, Switzerland.
authors: Thomas
authors: T
authors: Lung
authors: Labormedizinisches Zentrum Dr. Risch and Kantonsspital Graubünden, 7000 Chur, Switzerland.
authors: Lorenz
authors: L
authors: Risch
authors: Labormedizinisches Zentrum Dr. Risch and Kantonsspital Graubünden, 7000 Chur, Switzerland.
authors: Martin
authors: M
authors: Risch
authors: Labormedizinisches Zentrum Dr. Risch and Kantonsspital Graubünden, 7000 Chur, Switzerland.
authors: Pedro
authors: P
authors: Medina Escobar
authors: Labormedizinisches Zentrum Dr. Risch and Kantonsspital Graubünden, 7000 Chur, Switzerland.
authors: Thomas
authors: T
authors: Bodmer
mesh_terms: D000486:Allergy and Immunology; D002138:Calibration; D003176:Complement C3 / Q000737:chemistry; D003165:Complement System Proteins; D005819:Genetic Markers; D016678:Genome; D006405:Hematology / Q000379:methods; D006801:Humans; D007070:Immunoglobulin A / Q000737:chemistry; D007074:Immunoglobulin G / Q000737:chemistry; D007249:Inflammation; D013058:Mass Spectrometry; D055442:Metabolome; D055432:Metabolomics; D008829:Microbiology; D010363:Pattern Recognition, Automated; D010641:Phenotype; D012307:Risk Factors; D017422:Sequence Analysis, DNA; D014807:Vitamin D / Q000378:metabolism
chemical_list: D003176:Complement C3; D005819:Genetic Markers; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D014807:Vitamin D; D003165:Complement System Proteins