title: The Emergence of NMDA Receptor Metabotropic Function: Insights from Imaging.
abstract: The NMDA receptor (R) participates in many important physiological and pathological processes. For example, its activation is required for both long-term potentiation (LTP) and long-term depression (LTD) of synaptic transmission, cellular models of learning and memory. Furthermore, it may play a role in the actions of amyloid-beta on synapses as well as in the signaling leading to cell death following stroke. Until recently, these processes were thought to be mediated by ion-flux through the receptor. Using a combination of imaging and electrophysiological approaches, ion-flux independent functions of the NMDAR were recently examined. In this review, we will discuss the role of metabotropic NMDAR function in LTD and synaptic dysfunction.
authors: Center for Neural Circuits and Behavior, Department of Neuroscience and Section for Neurobiology, Division of Biology, University of California at San Diego San Diego, CA, USA.
authors: Kim
authors: K
authors: Dore
authors: Genome Institute of Singapore Singapore, Singapore.
authors: Jonathan
authors: J
authors: Aow
authors: Center for Neural Circuits and Behavior, Department of Neuroscience and Section for Neurobiology, Division of Biology, University of California at San Diego San Diego, CA, USA.
authors: Roberto
authors: R
authors: Malinow
keywords: FRET-FLIM; NMDAR interactions with CaMKII; PP1; amyloid-beta induced depression; excitotoxicity; ion-flux independent; long-term depression (LTD)