title: Successful allogeneic bone marrow transplantation with reduced intensity conditioning regimen for a pediatric relapsed ALK positive anaplastic large cell lymphoma.
abstract: Pediatric anaplastic large cell lymphoma (ALCL) is a chemosensitive malignancy, but about 30% of patients experience relapse. In most of these patients, a second complete remission is obtainable with salvage chemotherapy, though relapse free survival rates are as low as 30-60%. Herein, we report a 6-year-old boy with relapsed anaplastic lymphoma kinase (ALK) positive ALCL successfully treated with vinblastine monotherapy followed by allogeneic hematopoietic stem cell transplantation (allo-HSCT), with a reduced intensity conditioning (RIC) regimen, from his father. One HLA locus from the father was mismatched. The boy had neither severe graft-versus-host disease nor transplantation related complications. He is currently well and has remained disease free for 10 months, to date, since transplantation. Allo-HSCT with a RIC regimen may be a promising treatment strategy for relapsed ALK positive ALCL based on obtaining graft-versus lymphoma effects as well as reducing transplantation-related mortality.
authors: Department of Pediatrics, Jichi Medical University.
authors: Tomomi
authors: T
authors: Hayase
authors: Hitomi
authors: H
authors: Niijima
authors: Daisuke
authors: D
authors: Tanaka
authors: Syoya
authors: S
authors: Wada
authors: Yuta
authors: Y
authors: Kawahara
authors: Yukiko
authors: Y
authors: Oh
authors: Akira
authors: A
authors: Morimoto
mesh_terms: D016026:Bone Marrow Transplantation; D002648:Child; D006801:Humans; D017728:Lymphoma, Large-Cell, Anaplastic / Q000628:therapy*; D008297:Male; D012074:Remission Induction; D019172:Transplantation Conditioning; D014184:Transplantation, Homologous; D016896:Treatment Outcome