title: Peptide-based biocoatings for corrosion protection of stainless steel biomaterial in a chloride solution.
abstract: In this work, PEGylated D-amino acid K122-4 peptide (D-K122-4-PEG), derived from the type IV pilin of Pseudomonas aeruginosa, coated on 304 stainless steel was investigated for its corrosion resistant properties in a sodium chloride solution by various electrochemical measurements, surface characterization and molecular dynamics simulation. As a comparison, stainless steel electrodes coated with non-PEGylated D-amino acid retroinverso peptide (RI-K122-4) and D-amino acid K122-4 peptide (D-K122-4) were used as control variables during electrochemical tests. It was found that the D-K122-4-PEG coating is able to protect the stainless steel from corrosion in the solution. The RI-K122-4 coating shows corrosion resistant property and should be investigated further, while the D-K122-4 peptide coating, in contrast, shows little to no effect on corrosion. The morphological characterizations support the corrosion resistance of D-K122-4-PEG on stainless steel. The adsorption of D-K122-4 molecules occurs preferentially on Fe2O3, rather than Cr2O3, present on the stainless steel surface.
authors: Department of Mechanical & Manufacturing Engineering, University of Calgary, Calgary, AB T2N 1N4, Canada; Department of Medicine, University of Calgary, Calgary, AB T2N 1N4, Canada.
authors: Noah G G
authors: NGG
authors: Muruve
authors: Department of Mechanical & Manufacturing Engineering, University of Calgary, Calgary, AB T2N 1N4, Canada. Electronic address: fcheng@ucalgary.ca.
authors: Y Frank
authors: YF
authors: Cheng
authors: Department of Mechanical & Manufacturing Engineering, University of Calgary, Calgary, AB T2N 1N4, Canada.
authors: Yuanchao
authors: Y
authors: Feng
authors: Department of Mechanical & Manufacturing Engineering, University of Calgary, Calgary, AB T2N 1N4, Canada.
authors: Tao
authors: T
authors: Liu
authors: Department of Medicine, University of Calgary, Calgary, AB T2N 1N4, Canada.
authors: Daniel A
authors: DA
authors: Muruve
authors: Department of Molecular Genetics, Biochemistry and Microbiology, University of Cincinnati, Cincinnati, OH 45267, USA.
authors: Daniel J
authors: DJ
authors: Hassett
authors: Department of Medical Microbiology & Immunology, University of Alberta, Edmonton, AB T6G 2G6, Canada.
authors: Randall T
authors: RT
authors: Irvin
mesh_terms: D017608:Chromium Compounds / Q000737:chemistry; D020099:Coated Materials, Biocompatible / Q000737:chemistry*; D003343:Corrosion; D005290:Ferric Compounds / Q000737:chemistry; D036781:Fimbriae Proteins / Q000737:chemistry*; D010455:Peptides / Q000737:chemistry*; D011550:Pseudomonas aeruginosa / Q000737:chemistry*; D013193:Stainless Steel / Q000737:chemistry*
chemical_list: D017608:Chromium Compounds; D020099:Coated Materials, Biocompatible; D005290:Ferric Compounds; D010455:Peptides; D013193:Stainless Steel; D036781:Fimbriae Proteins; C000499:ferric oxide
keywords: Biocoatings; Corrosion protection; Electrochemical measurements; Molecular dynamics simulation; Peptides; Stainless steel