title: MORPHOMETRIC ANALYSIS OF HIPPOCAMPUS AND LATERAL VENTRICLE REVEALS REGIONAL DIFFERENCE BETWEEN COGNITIVELY STABLE AND DECLINING PERSONS.
abstract: Alzheimers disease (AD) is a progressive neurodegenerative disease most prevalent in the elderly. Distinguishing disease-related memory decline from normal age-related memory decline has been clinically difficult due to the subtlety of cognitive change during the preclinical stage of AD. In contrast, sensitive biomarkers derived from in vivo neuroimaging data could improve the early identification of AD. In this study, we employed a morphometric analysis in the hippocampus and lateral ventricle. A novel group-wise template-based segmentation algorithm was developed for ventricular segmentation. Further, surface multivariate tensor-based morphometry and radial distance on each surface point were computed. Using HotellingsT2test, we found significant morphometric differences in both hippocampus and lateral ventricle between stable and clinically declining subjects. The left hemisphere was more severely affected than the right during this early disease stage. Hippocampal and ventricular morphometry has significant potential as an imaging biomarker for onset prediction and early diagnosis of AD.
authors: School of Computing, Informatics, and Decision Systems Engineering, Arizona State Univ., Tempe, AZ.
authors: Wen
authors: W
authors: Zhang
authors: School of Computing, Informatics, and Decision Systems Engineering, Arizona State Univ., Tempe, AZ.
authors: Jie
authors: J
authors: Shi
authors: Dept. of Psychiatry and Psychology, Mayo Clinic Arizona, Scottsdale, AZ.
authors: Cynthia
authors: C
authors: Stonnington
authors: Banner Alzheimer's Institute, Phoenix, AZ.
authors: Robert J
authors: RJ
authors: Bauer
authors: Imaging Genetics Center, Institute for Neuroimaging and Informatics, Univ. of Southern California, Marina del Rey, CA.
authors: Boris A
authors: BA
authors: Gutman
authors: Banner Alzheimer's Institute, Phoenix, AZ.
authors: Kewei
authors: K
authors: Chen
authors: Imaging Genetics Center, Institute for Neuroimaging and Informatics, Univ. of Southern California, Marina del Rey, CA.
authors: Paul M
authors: PM
authors: Thompson
authors: Banner Alzheimer's Institute, Phoenix, AZ.
authors: Eric M
authors: EM
authors: Reiman
authors: Dept. of Neurology, Mayo Clinic Arizona, Scottsdale, AZ.
authors: Richard J
authors: RJ
authors: Caselli
authors: School of Computing, Informatics, and Decision Systems Engineering, Arizona State Univ., Tempe, AZ.
authors: Yalin
authors: Y
authors: Wang
keywords: Cognitive Decline; Hippocampus; Lateral Ventricle; Morphometry; Ventricle Segmentation