title: Diterpenoids from Callicarpa kwangtungensis and their NO inhibitory effects.
abstract: A phytochemical investigation of the leaves of Callicarpa kwangtungensis led to the isolation of three new diterpenoids (1-3), callipenes A-C, and eleven known analogues (4-14). Their structures were established on the basis of extensive analysis of NMR spectroscopic data, X-ray diffraction data, and experimental and calculated electronic circular dichroism spectra. Compounds 1 and 2 are rare abietane diterpenoids possessing a peroxide bridge. All of the isolates were found to inhibit LPS-induced NO production in BV-2 cells.
authors: State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy, and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin 300350, People's Republic of China.
authors: Jing
authors: J
authors: Xu
authors: State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy, and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin 300350, People's Republic of China.
authors: Shen
authors: S
authors: Li
authors: State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy, and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin 300350, People's Republic of China.
authors: Xiaocong
authors: X
authors: Sun
authors: State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy, and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin 300350, People's Republic of China.
authors: Jun
authors: J
authors: Ma
authors: State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy, and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin 300350, People's Republic of China.
authors: Feng
authors: F
authors: Liu
authors: State Key Laboratory of Core Technology in Innovative Chinese Medicine, Pharmaceutical Analysis Institute, Tasly Academy, Tianjin 300410, People's Republic of China.
authors: Ling
authors: L
authors: Tong
authors: Department of Biosystems and Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul 02841, Republic of Korea.
authors: Dongho
authors: D
authors: Lee
authors: Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai 980-8578, Japan.
authors: Yasushi
authors: Y
authors: Ohizumi
authors: College of Chemistry and Environmental Sciences, Laboratory of Xinjiang Native Medicinal and Edible Plant Resources Chemistry, Kashgar University, Kashgar 844000, People's Republic of China. Electronic address: 2673134206@qq.com.
authors: Muhetaer
authors: M
authors: Tuerhong
authors: State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy, and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin 300350, People's Republic of China. Electronic address: victgyq@nankai.edu.cn.
authors: Yuanqiang
authors: Y
authors: Guo
mesh_terms: D045784:Abietanes / Q000737:chemistry* / Q000302:isolation & purification; D000818:Animals; D032408:Callicarpa / Q000737:chemistry*; D002460:Cell Line; D004224:Diterpenes / Q000737:chemistry* / Q000302:isolation & purification; D051379:Mice; D015394:Molecular Structure; D009569:Nitric Oxide / Q000378:metabolism*; D018515:Plant Leaves / Q000737:chemistry
chemical_list: D045784:Abietanes; D004224:Diterpenes; D009569:Nitric Oxide
keywords: 7-Oxodehydroabietic acid (PubChem CID: 620189); 7α-Hydroxydehydroabietic acid (PubChem CID: 13370054); 7β-Hydroxydehydroabietic acid (PubChem CID: 13370052); Abietane diterpenoids; Angustanoic acid F (PubChem CID: 10591519); Callicarpa kwangtungensis; Diterpenoids; NO inhibitory effects; TDDFT ECD calculations