title: Clinicopathologic characteristics and outcomes of recurrent oropharyngeal squamous cell carcinoma.
abstract: OBJECTIVE
  Positive p16 immunohistochemical staining is predictive of improved survival and response to treatment. The purpose of this study is to determine the clinicopathologic characteristics and outcomes of patients with p16+ oropharynx cancer who fail initial treatment.
  
  
  METHODS
  Case series including all patients with recurrent oropharyngeal squamous cell carcinoma from 2002 to 2014.
  
  
  RESULTS
  Forty patients met inclusion criteria. Thirty-one (77.5%) tumors were p16+ and 9 (22.5%) were p16-. There was no difference in T/M stage at diagnosis; more patients with p16+ tumors presented initially with ≥N2 disease (p=0.04). Regional and/or metastatic recurrence was more common in the p16+ group as compared to the p16- group - 71% vs 22.2%, p=0.003. Outcomes for both groups were poor - 67.7% p16+ and 44.4% p16- patients died from disease.
  
  
  CONCLUSIONS
  Compared to p16- recurrent tumor patients, p16+ recurrent tumor patients were more likely to experience regional or distant metastatic recurrence. Overall outcomes for both p16+ and p16- recurrent oropharynx tumors were poor.
authors: Department of Otolaryngology, Head and Neck Surgery, University of California, San Francisco, 2233 Post Street, 3rd Floor, San Francisco, CA, USA. Electronic address: cheaton@ohns.ucsf.edu.
authors: Chase M
authors: CM
authors: Heaton
authors: School of Medicine, University of California, San Francisco, CA, USA.
authors: Karina
authors: K
authors: Yu
authors: Department of Pathology, University of California, San Francisco, CA, USA.
authors: Sarah
authors: S
authors: Calkins
authors: Department of Otolaryngology, Head and Neck Surgery, University of California, San Francisco, CA, USA.
authors: Jonathan R
authors: JR
authors: George
authors: Department of Otolaryngology, Head and Neck Surgery, University of California, San Francisco, CA, USA.
authors: William R
authors: WR
authors: Ryan
authors: Department of Otolaryngology, Head and Neck Surgery, University of California, San Francisco, CA, USA.
authors: Steven J
authors: SJ
authors: Wang
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000401:mortality / Q000473:pathology* / Q000628:therapy*; D015331:Cohort Studies; D019941:Cyclin-Dependent Kinase Inhibitor p16 / Q000378:metabolism; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000401:mortality / Q000473:pathology* / Q000628:therapy*; D009959:Oropharyngeal Neoplasms / Q000401:mortality / Q000473:pathology* / Q000628:therapy*; D016896:Treatment Outcome
chemical_list: C000614131:CDKN2A protein, human; D019941:Cyclin-Dependent Kinase Inhibitor p16