title: Cytokine decoy and scavenger receptors as key regulators of immunity and inflammation.
abstract: IL-1R2 was the first decoy receptor to be described. Subsequently receptors which act as pure decoys or scavengers or trigger dampening of cytokine signaling have been described for cytokines and chemokines. Here we review the current understanding of the mode of action and significance in pathology of the chemokine atypical receptor ACKR2, the IL-1 decoy receptor IL-1R2 and the atypical IL-1 receptor family IL-1R8. Decoy and scavenger receptors with no or atypical signaling have emerged as a general strategy conserved in evolution to tune the action of cytokines, chemokines and growth factors.
authors: Istituto Clinico Humanitas IRCCS, via Manzoni 113, 20089 Rozzano, Italy; Humanitas University, via Manzoni 113, 20089 Rozzano, Italy.
authors: Raffaella
authors: R
authors: Bonecchi
authors: Istituto Clinico Humanitas IRCCS, via Manzoni 113, 20089 Rozzano, Italy.
authors: Cecilia
authors: C
authors: Garlanda
authors: Istituto Clinico Humanitas IRCCS, via Manzoni 113, 20089 Rozzano, Italy; Humanitas University, via Manzoni 113, 20089 Rozzano, Italy. Electronic address: alberto.mantovani@humanitasresearch.it.
authors: Alberto
authors: A
authors: Mantovani
authors: Department of Animal Pathology, Faculty of Veterinary Medicine, University of Milan, Italy.
authors: Federica
authors: F
authors: Riva
mesh_terms: D000818:Animals; D018925:Chemokines; D016207:Cytokines / Q000235:genetics / Q000276:immunology / Q000378:metabolism*; D005786:Gene Expression Regulation; D006801:Humans; D007113:Immunity, Innate; D007249:Inflammation / Q000276:immunology* / Q000378:metabolism; D051379:Mice; D019707:Receptors, Chemokine / Q000235:genetics / Q000378:metabolism*; D017472:Receptors, Interleukin-1 / Q000235:genetics / Q000276:immunology / Q000378:metabolism*; D051116:Receptors, Scavenger / Q000235:genetics / Q000276:immunology / Q000378:metabolism*; D015398:Signal Transduction; D000097628:Chemokine Receptor D6
chemical_list: D018925:Chemokines; D016207:Cytokines; D019707:Receptors, Chemokine; D017472:Receptors, Interleukin-1; D051116:Receptors, Scavenger; C515708:ACKR2 protein, human; D000097628:Chemokine Receptor D6
keywords: Atypical chemokine receptor; Chemokine; Innate immunity; Interleukin-1; Regulation of inflammation