title: TLR1 Polymorphism Associations with Gastric Mucosa Morphologic Patterns on Magnifying NBI Endoscopy: a Prospective CrossSectional Study.
abstract: BACKGROUND
  Helicobacter pylori is now recognized as a causative factor of chronic gastritis, gastroduodenal ulcers, gastric cancer and mucosaassociated lymphatic tissue lymphoma. Tolllike receptors are important bacterial receptors in gastric epithelial cell signaling transduction and play critical roles in gastric carcinogenesis.
  
  
  METHODS
  A total of 400 patients undergoing esophagogastroduodenoscopy for investigation of chronic abdominal pain were genotyped for singlenucleotide polymorphisms (SNPs) in TLR1 (rs4833095) using TagMan SNPs genotyping assay by realtime PCR hybridization. Relationships with susceptibility to H. pylori infection and premalignant gastric mucosa morphological patterns, classified by magnifying NBI endoscopy, were investigated.
  
  
  RESULTS
  The percentages of TLR1 rs4833095, CC homozygous, CT heterozygous and TT homozygous cases were 34, 46.5 and 19%, respectively. CC showed statistical differences between H. pylori positive and negative cases (P<0.001). CT and TT correlated with type 1 and type 2 gastric mucosal morphological patterns (P<0.01) whereas CC correlated with types 3 and 4 (P<0.01).
  
  
  CONCLUSIONS
  This study demonstrated good correlation of TLR1 rs4833095 genotype with severity of inflammation in H. pylori infected gastric mucosa according to gastric mucosal morphologic patterns with magnifying NBI endoscopy.
authors: Department of surgery, Institute of Medicine, Suranaree University of Technology, Nakhon ratchasima, Thailand Email : Taweesak.t@sut.ac.th.
authors: Taweesak
authors: T
authors: Tongtawee
authors: Theeraya
authors: T
authors: Bartpho
authors: Soraya
authors: S
authors: Kaewpitoon
authors: Natthawut
authors: N
authors: Kaewpitoon
authors: Chavaboon
authors: C
authors: Dechsukhum
authors: Wilairat
authors: W
authors: Leeanansaksiri
authors: Ryan A
authors: RA
authors: Loyd
authors: Likit
authors: L
authors: Matrakool
authors: Sukij
authors: S
authors: Panpimanmas
mesh_terms: D000328:Adult; D003430:Cross-Sectional Studies; D005260:Female; D005753:Gastric Mucosa / Q000473:pathology* / Q000821:virology; D005756:Gastritis / Q000235:genetics / Q000473:pathology / Q000821:virology; D005773:Gastroscopy / Q000379:methods; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D016481:Helicobacter Infections / Q000235:genetics / Q000473:pathology / Q000821:virology; D016480:Helicobacter pylori / Q000472:pathogenicity; D006801:Humans; D008297:Male; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011446:Prospective Studies; D013270:Stomach / Q000473:pathology; D013274:Stomach Neoplasms / Q000235:genetics / Q000473:pathology / Q000821:virology; D051194:Toll-Like Receptor 1 / Q000235:genetics*
chemical_list: D051194:Toll-Like Receptor 1