title: Cutaneous malignant melanoma in a Haller's round ray Urobatis halleri.
abstract: Multiple black raised nodular masses were noted on the dorsal surface of an adult male Haller's round ray Urobatis halleri. Biopsy of 2 masses was performed, and histopathology revealed proliferative sheets of melanocytes exhibiting mild anisocytosis and anisokaryosis, supporting a diagnosis of malignant melanoma. Approximately 2 mo following the biopsy procedure, the round ray became acutely anorexic and was found dead in its enclosure. A full necropsy was performed, and tissues were submitted for histopathology. The black raised nodular masses again exhibited histologic features of a melanoma. In addition to the nodular masses present, multiple flat areas of increased pigmentation were also present throughout the course of the case and were not suggestive of neoplasia histologically. The transformation of benign to malignant neoplasia has been well described in other species and may have played a role in the development of multiple tumors in this case.
authors: National Marine Mammal Foundation, San Diego, California 92106, USA.
authors: Melissa R
authors: MR
authors: Nau
authors: David W
authors: DW
authors: Gardiner
authors: Erika
authors: E
authors: Nilson
authors: Todd L
authors: TL
authors: Schmitt
authors: Hendrik H
authors: HH
authors: Nollens
authors: Judy
authors: J
authors: St Leger
mesh_terms: D000818:Animals; D005393:Fish Diseases / Q000175:diagnosis* / Q000473:pathology; D008297:Male; D008545:Melanoma / Q000175:diagnosis / Q000473:pathology / Q000662:veterinary*; D012860:Skates, Fish; D012878:Skin Neoplasms / Q000175:diagnosis / Q000473:pathology / Q000662:veterinary*