title: Look Out Autophagy, Ubiquilin UPS Its Game.
abstract: Mutations in Ubiquilin-2 are linked to the onset of amyotrophic lateral sclerosis, but its connection to disease processes has remained unknown. Hjerpe et. al now report that Ubiquilin-2 enables the ubiquitin proteasome system (UPS) to single-handedly clear aggregated proteins, a cellular function previously thought to rely at least partially on autophagy.
authors: Department of Cell and Developmental Biology, Alexander Silberman Institute of Life Sciences, Hebrew University of Jerusalem 91904, Israel.
authors: Rachel
authors: R
authors: Brown
authors: Department of Cell and Developmental Biology, Alexander Silberman Institute of Life Sciences, Hebrew University of Jerusalem 91904, Israel. Electronic address: dan@cc.huji.ac.il.
authors: Daniel
authors: D
authors: Kaganovich
mesh_terms: D000690:Amyotrophic Lateral Sclerosis / Q000235:genetics; D001343:Autophagy; D018797:Cell Cycle Proteins / Q000235:genetics; D006801:Humans; D046988:Proteasome Endopeptidase Complex / Q000378:metabolism*; D025801:Ubiquitin / Q000378:metabolism*; D014452:Ubiquitins / Q000235:genetics
chemical_list: D018797:Cell Cycle Proteins; D025801:Ubiquitin; D014452:Ubiquitins; D046988:Proteasome Endopeptidase Complex