title: Solitary rectal ulcer syndrome: clinical, endoscopic, histological and anorectal manometry findings in north Indian patients.
abstract: BACKGROUND
  Solitary rectal ulcer syndrome (SRUS) is a chronic, benign defecation disorder often related to excessive straining. SRUS is diagnosed on the basis of clinical symptoms, endoscopic and histological findings.
  
  
  METHODS
  All patients diagnosed with SRUS by colonoscopy and confirmed by histopathology from October 2012 to August 2014 in the Department of Gastroenterology, Institute of Medical Sciences, Banaras Hindu University, India, were included in the study. Out of 92 patients, thirty-four patients underwent anorectal manometry. Twenty age-matched healthy volunteers were also studied with anorectal manometry to serve as controls.
  
  
  RESULTS
  Mean age of the group was 41 ± 19 years with age range of 10-82 years; males were 58 (63%) with male to female ratio of 1.7:1. Bleeding per rectum was present in 83%, constipation in 46.7%, abdominal pain in 27.2%, and diarrhea in 25% of the patients. On endoscopy, ulcerative lesions were seen in 83% patients of whom solitary and multiple lesions were present in 44% and 39%, respectively. Polypoidal lesions were reported in 17.4% whilst rectal polyps and erythematous mucosa were found in 5.4% and 2.2%, respectively. Histological examination revealed fibromuscular obliteration in 100% of patients, surface ulceration in 70.6% and crypt distortion in 20.65% of patients. Anal relaxation and balloon expulsion test was significantly abnormal in SRUS patients compared to healthy controls (53% vs. 20%, p < 0.01).
  
  
  CONCLUSIONS
  Rectal bleeding was the most common symptom and ulcerative lesions the most common endoscopic finding. Fecal evaluation disorder was more prevalent inpatients with SRUS.
authors: M K
authors: MK
authors: Behera
authors: V K
authors: VK
authors: Dixit
authors: S K
authors: SK
authors: Shukla
authors: J K
authors: JK
authors: Ghosh
authors: V B
authors: VB
authors: Abhilash
authors: P K
authors: PK
authors: Asati
authors: A K
authors: AK
authors: Jain
mesh_terms: D015746:Abdominal Pain / Q000209:etiology; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001003:Anal Canal / Q000473:pathology* / Q000503:physiopathology; D002648:Child; D003113:Colonoscopy; D003248:Constipation / Q000209:etiology; D003967:Diarrhea / Q000209:etiology; D005260:Female; D006471:Gastrointestinal Hemorrhage / Q000209:etiology; D006801:Humans; D007194:India; D008297:Male; D008365:Manometry; D008875:Middle Aged; D012002:Rectal Diseases / Q000150:complications / Q000473:pathology* / Q000503:physiopathology; D012007:Rectum / Q000473:pathology / Q000503:physiopathology; D013577:Syndrome; D014456:Ulcer / Q000150:complications / Q000473:pathology* / Q000503:physiopathology; D055815:Young Adult