title: A comparison of hemodynamic metrics and intraluminal thrombus burden in a common iliac artery aneurysm.
abstract: Aneurysms of the common iliac artery (CIAA) are typically found in association with an abdominal aortic aneurysm (AAA). Isolated CIAAs, in the absence of an AAA, are uncommon. Similar to AAAs, CIAA may develop intraluminal thrombus (ILT). As isolated CIAAs have a contralateral common iliac artery for comparison, they provide an opportunity to study the hemodynamic mechanisms behind ILT formation. In this study, we compared a large isolated CIAA and the contralateral iliac artery using computational fluid dynamics to determine if hemodynamic metrics correlate with the location of ILT. We performed a comprehensive computational fluid dynamics study and investigated the residence time of platelets and monocytes, velocity fields, time-averaged wall shear stress, oscillatory shear index, and endothelial cell activation potential. We then correlated these data to ILT burden determined with computed tomography. We found that high cell residence times, low time-averaged wall shear stress, high oscillatory shear index, and high endothelial cell activation potential all correlate with regions of ILT development. Our results show agreement with previous hypotheses of thrombus formation in AAA and provide insights into the computational hemodynamics of iliac artery aneurysms.
authors: Vascular Engineering Laboratory, Harry Perkins Institute of Medical Research, Perth, WA, Australia.|Intelligent Systems for Medicine Laboratory, School of Mechanical and Chemical Engineering, The University of Western Australia, Crawley, WA, Australia.
authors: Lachlan J
authors: LJ
authors: Kelsey
authors: Vascular Surgery Research Group, Imperial College London, London, UK.
authors: Janet T
authors: JT
authors: Powell
authors: Vascular Engineering Laboratory, Harry Perkins Institute of Medical Research, Perth, WA, Australia.|School of Surgery, The University of Western Australia, Crawley, WA, Australia.
authors: Paul E
authors: PE
authors: Norman
authors: Intelligent Systems for Medicine Laboratory, School of Mechanical and Chemical Engineering, The University of Western Australia, Crawley, WA, Australia.|Institute of Mechanics and Advanced Materials, Cardiff University, Cardiff, UK.
authors: Karol
authors: K
authors: Miller
authors: Vascular Engineering Laboratory, Harry Perkins Institute of Medical Research, Perth, WA, Australia.|School of Mechanical and Chemical Engineering, The University of Western Australia, Crawley, WA, Australia.|British Heart Foundation Centre for Cardiovascular Science, The University of Edinburgh, Edinburgh, UK.
authors: Barry J
authors: BJ
authors: Doyle
mesh_terms: D001012:Aorta, Abdominal / Q000473:pathology; D017544:Aortic Aneurysm, Abdominal / Q000473:pathology*; D001792:Blood Platelets; D042783:Endothelial Cells; D006439:Hemodynamics; D006801:Humans; D057446:Hydrodynamics; D007083:Iliac Artery / Q000473:pathology*; D009000:Monocytes; D013927:Thrombosis / Q000473:pathology*
keywords: computational fluid dynamics; iliac aneurysm; intraluminal thrombus; wall shear stress