title: Assessment of Cortical Dysfunction in Patients with Intermittent Exotropia: An fMRI Study.
abstract: Neural imaging studies have found the connection between strabismus and brain cortex. However, the pathological mechanisms of intermittent exotropia are still not fully understood. In the present study, changes of binocular fusion related cortices in intermittent exotropia were investigated with blood oxygen level dependent functional magnetic resonance imaging. Activated cortices induced by fusion stimulus were found to be distributed in several regions such as bilateral middle occipital gyrus, bilateral middle temporal gyrus, left superior parietal lobule and so on. Compared with normal subjects, the increased activation intensity was observed in bilateral superior parietal lobule and inferior parietal lobule in subjects with intermittent exotropia. These findings indicate that binocular fusion involves a complicated brain network including several regions. And cortical activities of bilateral superior parietal lobule and inferior parietal lobule compensate for the binocular fusion dysfunction in intermittent exotropia.
authors: Department of Optometry and Visual Science, West China School of Medicine, Sichuan University, Chengdu, Sichuan Province, P.R. China.
authors: Qian
authors: Q
authors: Li
authors: Department of Optometry and Visual Science, West China School of Medicine, Sichuan University, Chengdu, Sichuan Province, P.R. China.|Department of Ophthalmology, MEM Eye Care System, Beijing, P.R. China.
authors: Junxing
authors: J
authors: Bai
authors: Huaxi MR Research Center, Department of Radiology, West China Hospital, Sichuan University, Chengdu, Sichuan Province, P.R. China.
authors: Junran
authors: J
authors: Zhang
authors: Huaxi MR Research Center, Department of Radiology, West China Hospital, Sichuan University, Chengdu, Sichuan Province, P.R. China.
authors: Qiyong
authors: Q
authors: Gong
authors: Department of Optometry and Visual Science, West China School of Medicine, Sichuan University, Chengdu, Sichuan Province, P.R. China.
authors: Longqian
authors: L
authors: Liu
mesh_terms: D000293:Adolescent; D000328:Adult; D001921:Brain / Q000473:pathology*; D001931:Brain Mapping / Q000379:methods*; D016022:Case-Control Studies; D002540:Cerebral Cortex / Q000473:pathology*; D003430:Cross-Sectional Studies; D005099:Exotropia / Q000473:pathology*; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D010100:Oxygen / Q000097:blood; D055815:Young Adult
chemical_list: D010100:Oxygen