title: Comparative Outcomes after Haploidentical or Unrelated Donor Bone Marrow or Blood Stem Cell Transplantation in Adult Patients with Hematological Malignancies.
abstract: Most patients eligible for allogeneic hematopoietic stem cell transplantation will require identification of an alternate (unrelated or mismatched related) donor. We explored the transplantation outcomes for a sequential series of 54 patients undergoing haploidentical donor transplantation (HAPLO) compared to those from a control group of patients receiving cells from matched or mismatched unrelated donors (URD) selected by diagnosis and stem cell source. Patients undergoing HAPLO transplantations received graft-versus-host disease (GVHD) prophylaxis with post-transplantation cyclophosphamide (Cy). Day 15 neutrophil recovery was lower after HAPLO than in URD recipients (43% versus 77%, P < .001), as was day 30 platelet recovery (67% versus 84%, P = .043). HAPLO patients receiving bone marrow achieved neutrophil engraftment at a median of 17 days and platelet engraftment at a median of 29 days, compared with 16 days and 24 days, respectively, for recipients of peripheral blood stem cells. The incidence of graft failure was similar for both HAPLO and URD recipients (P = .42). HAPLO recipients were more likely to reach donor CD3 chimerism >95% by day 28 after transplantation (88% versus 62%, P = .003). The cumulative incidence of grades II to IV acute GVHD (aGVHD) at 6 months after transplantation did not differ for these 2 groups (63% for HAPLO and 53% for URD recipients; P = .269), nor did the cumulative incidence of severe grade III/IV aGVHD (13% for HAPLO and 8% for URD recipients; P = .44). The cumulative incidence of moderate or severe chronic GVHD at 2 years did not differ, with probabilities of 24% for HAPLO and 18% for URD recipients (P = .43). The cumulative incidence of cytomegalovirus reactivation by day 100 after transplantation did not differ (45% for HAPLO and 46% for URD recipients; P = .96). The HAPLO recipients experienced a lower incidence of Epstein-Barr virus reactivation by day 100 (6% versus 32%, P < .001) but a higher incidence of Human Herpesvirus-6 reactivation (35% versus 10%, P = .001). Relapse risk, regimen-related mortality, progression-free survival, and overall survival probabilities did not differ between these 2 groups. These data support the use of HAPLO transplantation with post-transplantation Cy as an alternate transplantation technique for patients lacking HLA-matched sibling donors. Transplantation of peripheral blood stem cells does not appear to enhance the speed of neutrophil recovery. The different patterns of viral reactivation require additional studies to explain.
authors: John Theurer Cancer Center, Hackensack University Medical Center, Hackensack, New Jersey.
authors: Melissa
authors: M
authors: Baker
authors: Department of Biostatistics, Bioinformatics, and Biomathematics, Georgetown University, Washington, DC.
authors: Hongkun
authors: H
authors: Wang
authors: John Theurer Cancer Center, Hackensack University Medical Center, Hackensack, New Jersey. Electronic address: scott.rowley@hackensackmeridian.org.
authors: Scott D
authors: SD
authors: Rowley
authors: Department of Biostatistics, Bioinformatics, and Biomathematics, Georgetown University, Washington, DC.
authors: Ling
authors: L
authors: Cai
authors: John Theurer Cancer Center, Hackensack University Medical Center, Hackensack, New Jersey.
authors: Andrew L
authors: AL
authors: Pecora
authors: John Theurer Cancer Center, Hackensack University Medical Center, Hackensack, New Jersey.
authors: Alan
authors: A
authors: Skarbnik
authors: John Theurer Cancer Center, Hackensack University Medical Center, Hackensack, New Jersey.
authors: David H
authors: DH
authors: Vesole
authors: John Theurer Cancer Center, Hackensack University Medical Center, Hackensack, New Jersey.
authors: Barbara
authors: B
authors: Adler-Brecher
authors: John Theurer Cancer Center, Hackensack University Medical Center, Hackensack, New Jersey.
authors: Daniel
authors: D
authors: Kim
authors: John Theurer Cancer Center, Hackensack University Medical Center, Hackensack, New Jersey.
authors: Michele L
authors: ML
authors: Donato
mesh_terms: D000328:Adult; D000368:Aged; D016026:Bone Marrow Transplantation / Q000009:adverse effects / Q000379:methods* / Q000401:mortality; D046528:Chimerism; D003520:Cyclophosphamide / Q000627:therapeutic use; D005260:Female; D006085:Graft Survival; D006086:Graft vs Host Disease / Q000517:prevention & control; D019337:Hematologic Neoplasms / Q000150:complications / Q000401:mortality / Q000628:therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D036102:Peripheral Blood Stem Cell Transplantation / Q000009:adverse effects / Q000379:methods* / Q000401:mortality; D011292:Premedication; D016019:Survival Analysis; D000075442:Transplantation, Haploidentical / Q000009:adverse effects / Q000401:mortality; D016896:Treatment Outcome; D061349:Unrelated Donors; D014775:Virus Activation; D055815:Young Adult
chemical_list: D003520:Cyclophosphamide
keywords: Haploidentical transplantation; Post-transplantation cyclophosphamide; Unrelated donor transplantation