title: Isolation of three new annonaceous acetogenins from Graviola fruit (Annona muricata) and their anti-proliferation on human prostate cancer cell PC-3.
abstract: Bioassay-guided fractionation of the fruit powder of Graviola (Annona muricata) was continued to be conducted and yielded three more novel bioactive compounds: C-35 annonaceous acetogenins, muricins M and N, and C-37 annonaceous acetogenins, muricenin. They all contain a mono-tetrahydrofuran ring and four hydroxyl groups. The structures were elucidated by spectral methods and chemical modification after isolation via open column chromatographic separation and HPLC purification. Especially, murices M and N demonstrated more potent anti-proliferative activities against human prostate cancer PC-3 cells.
authors: Department of Nutrition and Food Science, Wayne State University, 5045 Cass Ave, Detroit, MI 48202, United States.
authors: Shi
authors: S
authors: Sun
authors: Barbara Ann Karmanos Cancer Institute and Departments of Oncology, Pharmacology and Pathology, Wayne State University School of Medicine, Detroit, MI 48201, United States.
authors: Jingchun
authors: J
authors: Liu
authors: Department of Nutrition and Food Science, Wayne State University, 5045 Cass Ave, Detroit, MI 48202, United States.
authors: Ninghui
authors: N
authors: Zhou
authors: Department of Nutrition and Food Science, Wayne State University, 5045 Cass Ave, Detroit, MI 48202, United States.
authors: Wenjun
authors: W
authors: Zhu
authors: Barbara Ann Karmanos Cancer Institute and Departments of Oncology, Pharmacology and Pathology, Wayne State University School of Medicine, Detroit, MI 48201, United States.
authors: Q Ping
authors: QP
authors: Dou
authors: Department of Nutrition and Food Science, Wayne State University, 5045 Cass Ave, Detroit, MI 48202, United States. Electronic address: kzhou@wayne.edu.
authors: Kequan
authors: K
authors: Zhou
mesh_terms: D054378:Acetogenins / Q000737:chemistry* / Q000494:pharmacology*; D031041:Annona / Q000737:chemistry*; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000494:pharmacology; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D002851:Chromatography, High Pressure Liquid; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D015394:Molecular Structure; D011471:Prostatic Neoplasms / Q000188:drug therapy
chemical_list: D054378:Acetogenins; D000972:Antineoplastic Agents, Phytogenic; C000622111:muricenin; C000622109:muricin M; C000622110:muricin N
keywords: Acetogenin; Annona muricata; Human prostate cancer PC-3 cells; Muricin