title: Effect of l-DOPA on local field potential relationship between the pedunculopontine nucleus and primary motor cortex in a rat model of Parkinson's disease.
abstract: Levodopa (l-DOPA) has been proved to reverse the pathologic neuron activities in many brain regions related to Parkinson's disease (PD). But little is known about the effect of l-DOPA on the altered electrophysiological coherent activities between pedunculopontine nucleus (PPN) and motor cortex. To investigate this, local field potentials (LFPs) of PPN and primary motor cortex (M1) were recorded simultaneously in control, 6-hydroxydopamine lesioned and lesioned rats with l-DOPA chronic treatment. The results revealed that in resting state, chronic l-DOPA treatment could correct the suppressed power of LFPs in PPN and M1 in low-frequency band (1-7Hz) and the enhanced power in high-frequency band (7-70Hz in PPN and 12-70Hz in M1) of lesioned rats. In locomotor state, l-DOPA treatment could correct the alterations in most of frequency bands except the δ band in PPN and α band in M1. Moreover, l-DOPA could also reverse the altered coherent relationships caused by dopamine depletion in resting state between PPN and M1 in β band. And in locomotor state, l-DOPA had therapeutic effect on the alterations in δ and β bands but not in the α band. These findings provide evidence that l-DOPA can reverse the altered LFP activities in PPN and M1 and their relationships in a rat model of PD, which contributes to better understanding the electrophysiological mechanisms of the pathophysiology and therapy of PD.
authors: Key Laboratory of Animal Resistance of Shandong Province, college of life science, Shandong normal university, Jinan 250014, China.
authors: Xiwen
authors: X
authors: Geng
authors: Key Laboratory of Animal Resistance of Shandong Province, college of life science, Shandong normal university, Jinan 250014, China.
authors: Xuenan
authors: X
authors: Wang
authors: Key Laboratory of Animal Resistance of Shandong Province, college of life science, Shandong normal university, Jinan 250014, China; Qinhuangdao Medical School, Qinhuangdao 066000, China.
authors: Jinlu
authors: J
authors: Xie
authors: Key Laboratory of Animal Resistance of Shandong Province, college of life science, Shandong normal university, Jinan 250014, China; Shandong College of Electronic Technology, Jinan 250200, China.
authors: Xiao
authors: X
authors: Zhang
authors: Key Laboratory of Animal Resistance of Shandong Province, college of life science, Shandong normal university, Jinan 250014, China.
authors: Xiusong
authors: X
authors: Wang
authors: Key Laboratory of Animal Resistance of Shandong Province, college of life science, Shandong normal university, Jinan 250014, China.
authors: Yabing
authors: Y
authors: Hou
authors: Key Laboratory of Animal Resistance of Shandong Province, college of life science, Shandong normal university, Jinan 250014, China.
authors: Chengdong
authors: C
authors: Lei
authors: Key Laboratory of Animal Resistance of Shandong Province, college of life science, Shandong normal university, Jinan 250014, China.
authors: Min
authors: M
authors: Li
authors: Key Laboratory of Animal Resistance of Shandong Province, college of life science, Shandong normal university, Jinan 250014, China.
authors: Hongyu
authors: H
authors: Han
authors: Key Laboratory of Animal Resistance of Shandong Province, college of life science, Shandong normal university, Jinan 250014, China.
authors: Xiaomeng
authors: X
authors: Yao
authors: The Fourth People's Hospital of Jinan, Jinan 250031, China.
authors: Qun
authors: Q
authors: Zhang
authors: Key Laboratory of Animal Resistance of Shandong Province, college of life science, Shandong normal university, Jinan 250014, China. Electronic address: wangmin78@yahoo.com.
authors: Min
authors: M
authors: Wang
mesh_terms: D000818:Animals; D000978:Antiparkinson Agents / Q000494:pharmacology* / Q000627:therapeutic use; D001545:Benserazide / Q000494:pharmacology / Q000627:therapeutic use; D003216:Conditioning, Operant / Q000187:drug effects; D004195:Disease Models, Animal; D005071:Evoked Potentials / Q000187:drug effects*; D005583:Fourier Analysis; D007980:Levodopa / Q000494:pharmacology* / Q000627:therapeutic use; D008124:Locomotion / Q000187:drug effects; D008297:Male; D009044:Motor Cortex / Q000187:drug effects*; D016627:Oxidopamine / Q000633:toxicity; D010300:Parkinson Disease / Q000188:drug therapy / Q000209:etiology / Q000473:pathology*; D045042:Pedunculopontine Tegmental Nucleus / Q000187:drug effects*; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors
chemical_list: D000978:Antiparkinson Agents; D007980:Levodopa; D001545:Benserazide; D016627:Oxidopamine
keywords: Coherence; Levodopa; Local field potential; Parkinson’s disease; Primary motor cortex; The pedunculopontine nucleus