title: Oral sensory nerve damage: Causes and consequences.
abstract: Oral sensations (i.e., taste, oral somatosensation, retronasal olfaction) are integrated into a composite sense of flavor, which guides dietary choices with long-term health impact. The nerves carrying this input are vulnerable to peripheral damage from multiple sources (e.g., otitis media, tonsillectomy, head injury), and this regional damage can boost sensations elsewhere in the mouth because of central interactions among nerve targets. Mutual inhibition governs this compensatory process, but individual differences lead to variation in whole-mouth outcomes: some individuals are unaffected, others experience severe loss, and some encounter sensory increases that may (if experienced early in life) elevate sweet-fat palatability and body mass. Phantom taste, touch, or pain sensations (e.g., burning mouth syndrome) may also occur, particularly in those expressing the most taste buds. To identify and treat these conditions effectively, emerging clinical tests measure regional vs. whole-mouth sensation, stimulated vs. phantom cues, and oral anatomy. Scaling methods allowing valid group comparisons have strongly aided these efforts. Overall, advances in measuring oral sensory function in health and disease show promise for understanding the varied clinical consequences of nerve damage.
authors: Food Science and Human Nutrition Department, Institute of Food and Agricultural Sciences, University of Florida, 572 Newell Drive, P.O. Box 110370, Gainesville, FL, 32611-0370, USA. dsnyder@ufl.edu.
authors: Derek J
authors: DJ
authors: Snyder
authors: Food Science and Human Nutrition Department, Institute of Food and Agricultural Sciences, University of Florida, 572 Newell Drive, P.O. Box 110370, Gainesville, FL, 32611-0370, USA.
authors: Linda M
authors: LM
authors: Bartoshuk
mesh_terms: D006801:Humans; D009055:Mouth / Q000294:innervation*; D000857:Olfaction Disorders / Q000503:physiopathology*; D010523:Peripheral Nervous System Diseases / Q000503:physiopathology*; D013651:Taste Disorders / Q000503:physiopathology*
keywords: Burning mouth syndrome; Intensity scale; Obesity; Oral sensation; Otitis media; Phantom taste; Taste; Tonsillectomy