title: Modeling functional decline over time in sporadic inclusion body myositis.
abstract: The ability to individualize recommendations or expectations of disease progression based on a patient's unique characteristics has merit for use in sporadic inclusion body myositis (sIBM).
  
  
  
  Fifty-five subjects with sIBM completed a battery of strength and functional outcomes at 2 study visits. These were used to develop mathematical models of disease progression in patients with sIBM for use in clinical and research settings.
  
  
  
  The 6-minute walk test (6MWT) distance declined by an average of 27.5 meters (12%) per year. Significant factors that predict 6MWT were knee extension and plantarflexion strength and body weight, whereas the ability to stand from a chair was impacted by elbow extension strength. Stepping up on a curb was influenced by the patient's age at diagnosis and by knee extension. Statistical models to predict functional decline in sIBM were developed.
  
  
  
  Statistical models help explain the complex factors that influence decreased walking ability and other functional activities in sIBM. Muscle Nerve 55: 526-531, 2017.
authors: The Research Institute at Nationwide Children's Hospital, Center for Gene Therapy, 700 Children's Drive, Room AB1042, Columbus, Ohio, 43205, USA.
authors: Lindsay N
authors: LN
authors: Alfano
authors: The Research Institute at Nationwide Children's Hospital, Biostatistics Core, Columbus, Ohio, USA.
authors: Han
authors: H
authors: Yin
authors: The Research Institute at Nationwide Children's Hospital, Biostatistics Core, Columbus, Ohio, USA.
authors: Igor
authors: I
authors: Dvorchik
authors: The Research Institute at Nationwide Children's Hospital, Center for Gene Therapy, 700 Children's Drive, Room AB1042, Columbus, Ohio, 43205, USA.
authors: Elizabeth G
authors: EG
authors: Maus
authors: The Research Institute at Nationwide Children's Hospital, Center for Gene Therapy, 700 Children's Drive, Room AB1042, Columbus, Ohio, 43205, USA.
authors: Kevin M
authors: KM
authors: Flanigan
authors: The Research Institute at Nationwide Children's Hospital, Center for Gene Therapy, 700 Children's Drive, Room AB1042, Columbus, Ohio, 43205, USA.
authors: Jerry R
authors: JR
authors: Mendell
authors: The Research Institute at Nationwide Children's Hospital, Center for Gene Therapy, 700 Children's Drive, Room AB1042, Columbus, Ohio, 43205, USA.
authors: Linda P
authors: LP
authors: Lowes
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D016015:Logistic Models; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D008954:Models, Biological; D008962:Models, Theoretical; D053580:Muscle Strength / Q000502:physiology*; D018482:Muscle, Skeletal / Q000503:physiopathology*; D018979:Myositis, Inclusion Body / Q000175:diagnosis* / Q000503:physiopathology*; D012372:ROC Curve; D016138:Walking / Q000502:physiology
keywords: disease progression; function; logistic model; natural history; sporadic inclusion body myositis