title: Application of chemical mechanical polishing process on titanium based implants.
abstract: Modification of the implantable biomaterial surfaces is known to improve the biocompatibility of metallic implants. Particularly, treatments such as etching, sand-blasting or laser treatment are commonly studied to understand the impact of nano/micro roughness on cell attachment. Although, the currently utilized surface modification techniques are known to improve the amount of cell attachment, it is critical to control the level of attachment due to the fact that promotion of bioactivity is needed for prosthetic implants while the cardiac valves, which are also made of titanium, need demotion of cells attachment to be able to function. In this study, a new alternative is proposed to treat the implantable titanium surfaces by chemical mechanical polishing (CMP) technique. It is demonstrated that the application of CMP on the titanium surface helps in modifying the surface roughness of the implant in a controlled manner (inducing nano-scale smoothness or controlled nano/micro roughness). Simultaneously, it is observed that the application of CMP limits the bacteria growth by forming a protective thin surface oxide layer on titanium implants. It is further shown that there is an optimal level of surface roughness where the cell attachment reaches a maximum and the level of roughness is controllable through CMP.
authors: Ozyegin University, Faculty of Engineering, Mechanical Engineering Department, Nisantepe Mevki, Orman Sokak No: 26, Cekmekoy, Istanbul 34794, Turkey.
authors: Z
authors: Z
authors: Ozdemir
authors: TUBITAK Gebze Campus, Genetic Engineering and Biotechnology Institute, P.O Box 21, Gebze, Kocaeli 41470, Turkey.
authors: A
authors: A
authors: Ozdemir
authors: Ozyegin University, Faculty of Engineering, Mechanical Engineering Department, Nisantepe Mevki, Orman Sokak No: 26, Cekmekoy, Istanbul 34794, Turkey. Electronic address: Bahar.Basim@ozyegin.edu.tr.
authors: G B
authors: GB
authors: Basim
mesh_terms: D000818:Animals; D002460:Cell Line; D005347:Fibroblasts / Q000166:cytology / Q000378:metabolism*; D020007:Implants, Experimental; D008422:Materials Testing; D051379:Mice; D013499:Surface Properties; D014025:Titanium / Q000737:chemistry*
chemical_list: D014025:Titanium
keywords: Biocompatibility; Chemical mechanical polishing; Implantable biomaterials; Surface structuring