title: Prostate-Specific Antigen: Nonspecific in Deceased Organ Donors.
abstract: Currently, there is no clear position regarding the donation of organs from donors with prostate carcinoma (CaP) in European countries, except Italy. The lengthening of life expectancy increases the probability of prostate cancer among potential organ donors. The concentration of prostate-specific antigen (PSA) >2 ng/mL at 60 years of age is related to the increasing possibility of identifying an advanced form of CaP. In recent years in Poland, the recommendation has been to determine tumor markers in potential donors. In the first year of the recommendation, 10% of potential male cadaveric donors were disqualified in West Pomerania, Poland, on the basis of elevated PSA levels (>10 ng/mL). To avoid reduction of the actual donor pool, each potential male donor reported to the center since January 2010 undergoes a routine histologic evaluation of the whole prostate, regardless of the PSA level, before organ implantation. In the study group (N = 52), histopathologic evaluation revealed 6 cases of CaP (12%). In CaP positive group Gleason score range from 2+2 to 3+4. In CaP donors PSA level have been noticed in range 1.79 ng/mL - 7.66 ng/mL. There was no correlation between histologically confirmed CaP and the PSA level.
authors: Department of Nephrology Transplantation and Internal Medicine, Pomeranian Medical University, Szczecin, Poland; Polish Transplant Coordinating Center-Poltransplant, Warsaw, Poland. Electronic address: bkpn@pum.edu.pl.
authors: K
authors: K
authors: Pabisiak
authors: Department of General Surgery and Transplantation, Pomeranian Medical University, Szczecin, Poland.
authors: M
authors: M
authors: Ostrowski
authors: West Pomeranian Oncology Center, Szczecin, Poland.
authors: A
authors: A
authors: Kram
authors: Department of Biochemistry and Medical Chemistry, Pomeranian Medical University, Szczecin, Poland.
authors: K
authors: K
authors: Safranow
authors: Department of Nephrology Transplantation and Internal Medicine, Pomeranian Medical University, Szczecin, Poland.
authors: M
authors: M
authors: Myślak
authors: Department of General Surgery and Transplantation, Pomeranian Medical University, Szczecin, Poland.
authors: J
authors: J
authors: Sieńko
authors: Department of General Surgery and Transplantation, Pomeranian Medical University, Szczecin, Poland.
authors: T
authors: T
authors: Sulikowski
authors: Department of Nephrology Transplantation and Internal Medicine, Pomeranian Medical University, Szczecin, Poland.
authors: K
authors: K
authors: Ciechanowski
mesh_terms: D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000097:blood*; D002277:Carcinoma / Q000097:blood* / Q000175:diagnosis / Q000473:pathology; D003643:Death; D046148:Donor Selection / Q000379:methods*; D005060:Europe; D006801:Humans; D007558:Italy; D008297:Male; D008875:Middle Aged; D011044:Poland; D017430:Prostate-Specific Antigen / Q000097:blood*; D011470:Prostatic Hyperplasia / Q000097:blood* / Q000175:diagnosis / Q000473:pathology; D019048:Prostatic Intraepithelial Neoplasia / Q000097:blood* / Q000175:diagnosis / Q000473:pathology; D011471:Prostatic Neoplasms / Q000097:blood* / Q000175:diagnosis / Q000473:pathology; D012307:Risk Factors; D013997:Time Factors; D014019:Tissue Donors; D014546:Urinary Catheterization; D055815:Young Adult
chemical_list: D014408:Biomarkers, Tumor; D017430:Prostate-Specific Antigen