title: Symmetric Dimethylarginine: Improving the Diagnosis and Staging of Chronic Kidney Disease in Small Animals.
abstract: Chronic kidney disease (CKD) is a common condition in cats and dogs, traditionally diagnosed after substantial loss of kidney function when serum creatinine concentrations increase. Symmetric dimethylarginine (SDMA) is a sensitive circulating kidney biomarker whose concentrations increase earlier than creatinine as glomerular filtration rate decreases. Unlike creatinine SDMA is unaffected by lean body mass. The IDEXX SDMA test introduces a clinically relevant and reliable tool for the diagnosis and management of kidney disease. SDMA has been provisionally incorporated into the International Renal Interest Society guidelines for CKD to aid staging and targeted treatment of early and advanced disease.
authors: Companion Animal Group Medical Organization, IDEXX, 1 IDEXX Drive, Westbrook, ME 04092, USA.
authors: Roberta
authors: R
authors: Relford
authors: Companion Animal Group Medical Organization, IDEXX, 1 IDEXX Drive, Westbrook, ME 04092, USA.
authors: Jane
authors: J
authors: Robertson
authors: Companion Animal Group Medical Organization, IDEXX, 1 IDEXX Drive, Westbrook, ME 04092, USA. Electronic address: celeste-clements@idexx.com.
authors: Celeste
authors: C
authors: Clements
mesh_terms: D000818:Animals; D001120:Arginine / Q000031:analogs & derivatives* / Q000097:blood; D015415:Biomarkers / Q000097:blood; D002371:Cat Diseases / Q000097:blood / Q000175:diagnosis*; D002415:Cats; D004283:Dog Diseases / Q000097:blood / Q000175:diagnosis*; D004285:Dogs; D051436:Renal Insufficiency, Chronic / Q000097:blood* / Q000175:diagnosis
chemical_list: D015415:Biomarkers; C024917:symmetric dimethylarginine; D001120:Arginine
keywords: CKD; Chronic kidney disease; GFR; IDEXX SDMA test; IRIS; Renal biomarker; SDMA; Symmetric dimethylarginine