title: Ruthenium-Catalyzed Hydroalkynylative Cyclization of 1,6-Enynes Induced by Substituent Effects.
abstract: The ruthenium-catalyzed 1,6-enyne cyclization in the presence of bulky substituted terminal alkyne proceeds smoothly at room temperature to afford highly substituted five-membered cyclic compounds featuring a 1,5-enyne motif. Deuterium-labeling experiments showed that the key ruthenacyclopentene intermediate undergoes cleavage of metal-carbon bonds through the metal-assisted σ-bond metathesis reaction, thus leading to the formation of C(sp(2))-H and C(sp(3))-C(sp) bonds.
authors: Aix Marseille Université, CNRS , Cent Marseille, iSm2, Marseille 13013, France.
authors: Rui
authors: R
authors: Liu
authors: Aix Marseille Université, CNRS , Cent Marseille, iSm2, Marseille 13013, France.
authors: Zhenjie
authors: Z
authors: Ni
authors: Aix Marseille Université, CNRS , Cent Marseille, iSm2, Marseille 13013, France.
authors: Laurent
authors: L
authors: Giordano
authors: Aix Marseille Université, CNRS , Cent Marseille, iSm2, Marseille 13013, France.
authors: Alphonse
authors: A
authors: Tenaglia