title: Serum proatrial natriuretic peptide does not increase with higher systolic blood pressure in obese men.
abstract: Obese persons have low circulating natriuretic peptide (NP) concentrations. It has been proposed that this 'natriuretic handicap' could play a role in obesity-related hypertension. The normal physiological response of the NP system to an increase in blood pressure (BP) is an increase in NP secretion with concomitant higher circulating NP concentrations. In this study, we investigated whether higher BP would also be related to higher circulating NP concentrations in obese men; furthermore, we verified that BP had affected the hearts of our study participants, by determining left ventricular mass (LVM).
  
  
  
  We examined 103 obese healthy medication-free men. We measured 24-hour ambulatory BP (ABP). LVM was calculated using the Cornell voltage-duration product method. Fasting serum concentrations of midregional proatrial NP (MR-proANP), a surrogate for active ANP, were measured. Linear regression analysis was used to calculate age-adjusted standardised regression coefficients (β).
  
  
  
  LVM and BP increased across systolic ABP quartiles (mean LVM±SD: 1599.1±387.2 mm ms in first vs 2188.5±551.3 mm ms in fourth quartile, p<0.001; mean systolic ABP±SD: 114.5±4.2 mm Hg in first vs 149.0±7.7 mm Hg in fourth quartile, p<0.001). Systolic ABP was robustly associated with LVM (ß=0.48, p<0.001). Despite evidence of BP-related increases in LVM, serum MR-proANP was negatively associated with systolic ABP (ß=-0.32, p=0.004) and with diastolic ABP (ß=-0.45, p<0.001).
  
  
  
  Contrary to known physiological BP responses, MR-proANP was negatively associated with ABP in our study. This suggests that a low amount of circulating NPs could play a role in the early stage of obesity-related hypertension.
authors: Department of Clinical Physiology, Rigshospitalet Glostrup, University of Copenhagen, Glostrup, Denmark.
authors: Camilla L
authors: CL
authors: Asferg
authors: Department of Clinical Physiology, Rigshospitalet Glostrup, University of Copenhagen, Glostrup, Denmark.
authors: Ulrik B
authors: UB
authors: Andersen
authors: Research Centre for Prevention and Health, the Capital Region of Denmark, Copenhagen, Denmark.|Department of Clinical Experimental Research, Rigshospitalet, University of Copenhagen, Glostrup, Denmark.|Faculty of Health and Medical Sciences, University of Copenhagen, Denmark.
authors: Allan
authors: A
authors: Linneberg
authors: Department of Congenital Disorders, Statens Serum Institut, Copenhagen, Denmark.
authors: Paula L
authors: PL
authors: Hedley
authors: Department of Congenital Disorders, Statens Serum Institut, Copenhagen, Denmark.
authors: Michael
authors: M
authors: Christiansen
authors: Department of Clinical Chemistry, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
authors: Jens P
authors: JP
authors: Goetze
authors: Faculty of Health and Medical Sciences, University of Copenhagen, Denmark.|Department of Medicine, Amager Hvidovre Hospital Glostrup, University of Copenhagen, Glostrup, Denmark.
authors: Jørgen L
authors: JL
authors: Jeppesen
mesh_terms: D000328:Adult; D000368:Aged; D009320:Atrial Natriuretic Factor / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D001794:Blood Pressure / Q000502:physiology; D018660:Blood Pressure Monitoring, Ambulatory / Q000379:methods; D005260:Female; D006352:Heart Ventricles / Q000473:pathology; D006801:Humans; D006973:Hypertension / Q000097:blood* / Q000209:etiology / Q000473:pathology / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000097:blood* / Q000150:complications / Q000473:pathology / Q000503:physiopathology
chemical_list: D015415:Biomarkers; D009320:Atrial Natriuretic Factor
keywords: ECG/electrocardiogram