title: Recent developments in the detection and management of acute kidney injury.
abstract: Acute kidney injury (AKI) is a common condition in children admitted to hospital and existing serum and urine biomarkers are insensitive. There have been significant developments in stratifying the risk of AKI in children and also in the identification of new AKI biomarkers. Risk stratification coupled with a panel of AKI biomarkers will improve future detection of AKI, however, paediatric validation studies in mixed patient cohorts are required. The principles of effective management rely on treating the underlying cause and preventing secondary AKI by the appropriate use of fluids and medication. Further therapeutic innovation will depend on improving our understanding of the basic mechanisms underlying AKI in children.
authors: Department of Paediatric Nephrology, Central Manchester University Hospitals NHS Foundation Trust (CMFT), Manchester Academic Health Science Centre (MAHSC), Manchester, UK.
authors: James
authors: J
authors: McCaffrey
authors: Department of Paediatric Nephrology, Central Manchester University Hospitals NHS Foundation Trust (CMFT), Manchester Academic Health Science Centre (MAHSC), Manchester, UK.|KIST Medical College and Teaching Hospital, Imadol, Lalitpur, Nepal.
authors: Ajaya Kumar
authors: AK
authors: Dhakal
authors: Department of Nephrology, Birmingham Children's Hospital, Birmingham, UK.
authors: David V
authors: DV
authors: Milford
authors: Department of Paediatric Nephrology, Central Manchester University Hospitals NHS Foundation Trust (CMFT), Manchester Academic Health Science Centre (MAHSC), Manchester, UK.
authors: Nicholas J A
authors: NJ
authors: Webb
authors: Department of Paediatric Nephrology, Central Manchester University Hospitals NHS Foundation Trust (CMFT), Manchester Academic Health Science Centre (MAHSC), Manchester, UK.|Wellcome Trust Centre for Cell-Matrix Research, University of Manchester, Manchester, UK.
authors: Rachel
authors: R
authors: Lennon
mesh_terms: D058186:Acute Kidney Injury / Q000175:diagnosis* / Q000628:therapy; D015415:Biomarkers / Q000378:metabolism*; D002648:Child; D003404:Creatinine / Q000378:metabolism; D042241:Early Diagnosis; D006801:Humans; D010808:Physical Examination / Q000379:methods; D018570:Risk Assessment / Q000379:methods
chemical_list: D015415:Biomarkers; D003404:Creatinine
keywords: Acute kidney injury; Biomarker; Stratification