title: Antitumor Effects of JAK3 Inhibitor on the Model of Transplantable Lewis Lung Carcinoma and Mechanisms of Their Development.
abstract: Mice with Lewis lung carcinoma were used to study the antitumor and antimetastatic effects of JAK3 inhibitor. The study revealed no effect of JAK3 inhibitor on the growth of primary tumor node, but found a pronounced inhibition of hematogenous spread of the pathologic process into the lungs. In vitro blockade of JAK3 in cultured Lewis lung carcinoma produced no effect on the count of the stem tumor cells and stimulated functions of committed elements. In addition, blockade of JAK3 significantly elevated maturation index of the tumor tissue.
authors: E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia. zgn@pharm.tsu.ru.|Laboratory of Physical Processes Modeling in Biology and Medicine, National Research Tomsk State University, Tomsk, Russia. zgn@pharm.tsu.ru.
authors: G N
authors: GN
authors: Zyuz'kov
authors: E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia.
authors: E N
authors: EN
authors: Amosova
authors: E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia.
authors: A V
authors: AV
authors: Chaikovskii
authors: E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia.
authors: L A
authors: LA
authors: Miroshnichenko
authors: E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia.
authors: E V
authors: EV
authors: Udut
authors: E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia.
authors: O Yu
authors: OY
authors: Rybalkina
authors: E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia.
authors: V V
authors: VV
authors: Zhdanov
authors: E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia.|Laboratory of Physical Processes Modeling in Biology and Medicine, National Research Tomsk State University, Tomsk, Russia.
authors: V V
authors: VV
authors: Udut
authors: E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia.
authors: A M
authors: AM
authors: Dygai
authors: E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia.
authors: E P
authors: EP
authors: Zueva
mesh_terms: D000818:Animals; D018827:Carcinoma, Lewis Lung / Q000188:drug therapy* / Q000201:enzymology*; D004791:Enzyme Inhibitors / Q000494:pharmacology / Q000627:therapeutic use*; D005260:Female; D053616:Janus Kinase 3 / Q000037:antagonists & inhibitors*; D051379:Mice; D008810:Mice, Inbred C57BL; D014411:Neoplastic Stem Cells / Q000187:drug effects / Q000378:metabolism
chemical_list: D004791:Enzyme Inhibitors; D053616:Janus Kinase 3
keywords: JAK; cancer stem cells; intracellular signaling; targeted therapy; tumor diseases