title: Tributyltin chloride induces renal dysfunction by inflammation and oxidative stress in female rats.
abstract: Tributyltin chloride (TBT) is an organometallic pollutant that is used as a biocide in antifouling paints. TBT induces several toxic and endocrine-disrupting effects. However, studies evaluating the effects of TBT on renal function are rare. This study demonstrates that TBT exposure is responsible for improper renal function as well as the development of abnormal morphophysiology in mammalian kidneys. Female rats were treated with TBT, and their renal morphophysiology was assessed. Morphophysiological abnormalities such as decreased glomerular filtration rate and increased proteinuria levels were observed in TBT rats. In addition, increases in inflammation, collagen deposition and α-smooth muscle actin (α-SMA) protein expression were observed in TBT kidneys. A disrupted cellular redox balance and apoptosis in kidney tissue were also observed in TBT rats. TBT rats demonstrated reduced serum estrogen levels and estrogen receptor-α (ERα) protein expression in renal cortex. Together, these data provide in vivo evidence that TBT is toxic to normal renal function and that these effects may be associated with renal histopathology complications, such as inflammation and fibrosis.
authors: Department of Morphology, Federal University of Espírito Santo, Brazil.
authors: João V S
authors: JV
authors: Coutinho
authors: Department of Morphology, Federal University of Espírito Santo, Brazil.
authors: Leandro C
authors: LC
authors: Freitas-Lima
authors: Department of Physiological Sciences, Federal University of Espírito Santo, Brazil.
authors: Frederico F C T
authors: FF
authors: Freitas
authors: Department of Physiological Sciences, Federal University of Espírito Santo, Brazil.
authors: Flávia P S
authors: FP
authors: Freitas
authors: Department of Morphology, Federal University of Espírito Santo, Brazil.
authors: Priscila L
authors: PL
authors: Podratz
authors: Department of Morphology, Federal University of Espírito Santo, Brazil.
authors: Rafaella P L
authors: RP
authors: Magnago
authors: Department of Physiological Sciences, Federal University of Espírito Santo, Brazil.
authors: Marcella L
authors: ML
authors: Porto
authors: Department of Physiological Sciences, Federal University of Espírito Santo, Brazil.
authors: Silvana S
authors: SS
authors: Meyrelles
authors: Department of Physiological Sciences, Federal University of Espírito Santo, Brazil.
authors: Elisardo C
authors: EC
authors: Vasquez
authors: Department of Chemistry, Federal University of Espírito Santo, Brazil.
authors: Poliane A A
authors: PA
authors: Brandão
authors: Department of Chemistry, Federal University of Espírito Santo, Brazil.
authors: Maria T W D
authors: MT
authors: Carneiro
authors: Experimental Endocrinology Research Group, Institute of Biomedical Sciences, Federal University of Rio de Janeiro, Brazil.
authors: Francisca D
authors: FD
authors: Paiva-Melo
authors: Experimental Endocrinology Research Group, Institute of Biomedical Sciences, Federal University of Rio de Janeiro, Brazil; Postgraduate Program in Endocrinology, School of Medicine, Federal University of Rio de Janeiro, Brazil.
authors: Leandro
authors: L
authors: Miranda-Alves
authors: Department of Morphology, Federal University of Espírito Santo, Brazil.
authors: Ian V
authors: IV
authors: Silva
authors: Department of Physiological Sciences, Federal University of Espírito Santo, Brazil. Electronic address: agatagava@hotmail.com.
authors: Agata L
authors: AL
authors: Gava
authors: Department of Morphology, Federal University of Espírito Santo, Brazil. Electronic address: jbgraceli@gmail.com.
authors: Jones B
authors: JB
authors: Graceli
mesh_terms: D000199:Actins / Q000819:agonists / Q000378:metabolism; D000818:Animals; D017209:Apoptosis / Q000187:drug effects; D015415:Biomarkers / Q000097:blood / Q000378:metabolism / Q000652:urine; D003094:Collagen / Q000819:agonists / Q000378:metabolism; D004202:Disinfectants / Q000008:administration & dosage / Q000633:toxicity*; D004305:Dose-Response Relationship, Drug; D052244:Endocrine Disruptors / Q000633:toxicity; D004785:Environmental Pollutants / Q000008:administration & dosage / Q000633:toxicity*; D047628:Estrogen Receptor alpha / Q000037:antagonists & inhibitors / Q000378:metabolism; D004967:Estrogens / Q000097:blood; D005260:Female; D005355:Fibrosis; D007668:Kidney / Q000187:drug effects* / Q000276:immunology / Q000473:pathology / Q000503:physiopathology; D008407:Mast Cells / Q000187:drug effects / Q000276:immunology / Q000473:pathology; D018384:Oxidative Stress / Q000187:drug effects*; D011507:Proteinuria / Q000209:etiology; D017208:Rats, Wistar; D051437:Renal Insufficiency / Q000139:chemically induced* / Q000276:immunology / Q000473:pathology / Q000503:physiopathology; D014001:Tin / Q000097:blood; D066007:Toxicokinetics; D014220:Trialkyltin Compounds / Q000008:administration & dosage / Q000633:toxicity*
chemical_list: D000199:Actins; D015415:Biomarkers; D003094:Collagen; D004202:Disinfectants; D052244:Endocrine Disruptors; D004785:Environmental Pollutants; D047628:Estrogen Receptor alpha; D004967:Estrogens; D014001:Tin; D014220:Trialkyltin Compounds; C498862:Acta2 protein, rat; C011559:tributyltin
keywords: Estrogen; Inflammation; Oxidative stress; Renal function; Tributyltin chloride