title: Contrary microRNA Expression Pattern Between Fetal and Adult Cardiac Remodeling: Therapeutic Value for Heart Failure.
abstract: microRNAs (miRNAs) belong to a class of non-coding RNAs that regulate post-transcriptional gene expression during development and disease. Growing evidence indicates abundant miRNA expression changes and their important role in cardiac hypertrophy and failure. However, the role of miRNAs in fetal cardiac remodeling is little known. Here, we investigated the altered expression of fifteen miRNAs in rat fetal cardiac remodeling compared with adult cardiac remodeling. Among fifteen tested miRNAs, eleven and five miRNAs (miR-199a-5p, miR-214-3p, miR-155-3p, miR-155-5p and miR-499-5p) are significantly differentially expressed in fetal and adult cardiac remodeling, respectively. After comparison of miRNA expression in fetal and adult cardiac remodeling, we find that miRNA expression returns to the fetal level in adult cardiac failure and is activated in advance of the adult level in fetal failure. The current study highlights the contrary expression pattern between fetal and adult cardiac remodeling and that supports a novel potential therapeutic approach to treating heart failure.
authors: Department of Pediatric Cardiology, West China Second University Hospital, Sichuan University, No. 20, 3rd Section, South Renmin Road, Chengdu, 610041, Sichuan, China.|West China Medical School, Sichuan University, Chengdu, China.
authors: Hualin
authors: H
authors: Yan
authors: Department of Pediatric Cardiology, West China Second University Hospital, Sichuan University, No. 20, 3rd Section, South Renmin Road, Chengdu, 610041, Sichuan, China.|Key Laboratory of Ministry of Education for Women and Children's Diseases and Birth Defects, West China Second University Hospital, Sichuan University, Chengdu, China.
authors: Yifei
authors: Y
authors: Li
authors: Department of Pediatric Cardiology, West China Second University Hospital, Sichuan University, No. 20, 3rd Section, South Renmin Road, Chengdu, 610041, Sichuan, China.|West China Medical School, Sichuan University, Chengdu, China.
authors: Chuan
authors: C
authors: Wang
authors: Key Laboratory of Ministry of Education for Women and Children's Diseases and Birth Defects, West China Second University Hospital, Sichuan University, Chengdu, China.
authors: Yi
authors: Y
authors: Zhang
authors: Key Laboratory of Ministry of Education for Women and Children's Diseases and Birth Defects, West China Second University Hospital, Sichuan University, Chengdu, China.
authors: Cong
authors: C
authors: Liu
authors: Department of Pediatric Cardiology, West China Second University Hospital, Sichuan University, No. 20, 3rd Section, South Renmin Road, Chengdu, 610041, Sichuan, China. kaiyuzhou313@163.com.|Key Laboratory of Ministry of Education for Women and Children's Diseases and Birth Defects, West China Second University Hospital, Sichuan University, Chengdu, China. kaiyuzhou313@163.com.
authors: Kaiyu
authors: K
authors: Zhou
authors: Department of Pediatric Cardiology, West China Second University Hospital, Sichuan University, No. 20, 3rd Section, South Renmin Road, Chengdu, 610041, Sichuan, China. nathan_hua@163.com.|Key Laboratory of Ministry of Education for Women and Children's Diseases and Birth Defects, West China Second University Hospital, Sichuan University, Chengdu, China. nathan_hua@163.com.
authors: Yimin
authors: Y
authors: Hua
mesh_terms: D000367:Age Factors; D000818:Animals; D006332:Cardiomegaly / Q000196:embryology / Q000235:genetics* / Q000473:pathology*; D005260:Female; D020869:Gene Expression Profiling / Q000379:methods; D018507:Gene Expression Regulation, Developmental; D006333:Heart Failure / Q000196:embryology / Q000235:genetics* / Q000473:pathology*; D035683:MicroRNAs / Q000096:biosynthesis / Q000235:genetics*; D011247:Pregnancy; D051381:Rats; D017207:Rats, Sprague-Dawley; D020257:Ventricular Remodeling / Q000235:genetics*
chemical_list: D035683:MicroRNAs
keywords: Cardiac remodeling; Fetal cardiac remodeling; Heart failure; Metabolic remodeling; microRNA