title: Plasma lipoprotein(a) levels are associated with the severity of coronaryheart disease in Han Chinese people.
abstract: OBJECTIVE
  The aim of this study was to investigate the association of lipoprotein(a) [Lp(a)] with the severity of coronary heart disease (CHD) in Han Chinese people.
  
  
  METHODS
  Six hundred and seventy-nine patients with angiographically defined CHD were enrolled in this cross-sectional study. Fasting lipids were measured, and the severity of CHD was quantitatively assessed for each patient according to the number of stenotic coronary branches and the Gensini scoring system.
  
  
  RESULTS
  The levels of Lp(a), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), very low-density lipoprotein cholesterol (VLDL-C), and apolipoprotein (apo) B100 increased, while high-density lipoprotein cholesterol (HDL-C) and apoAI decreased significantly with the number of stenotic vessels. The levels of Lp(a) increased and HDL-C and apoAI decreased significantly with the Gensini scores. The logistic regression analyses showed that Lp(a) and HDL-C were independently associated with the number of stenotic coronary vessels after adjusting for age, weight, body mass index, sex, smoking, alcohol consumption, hypertension, diabetes, triglycerides, TC, LDL-C, VLDL-C, apoAI, and apoB100. However, only Lp(a) was independently associated with the Gensini scores after adjustment.
  
  
  CONCLUSIONS
  Our data indicate that Lp(a) might be a useful marker in predicting the severity of coronary heart disease.
authors: Department of Cardiology, Afﬁliated Hospital of North Sichuan Medical College, Nanchong, Sichuan Province, P.R. China.
authors: Li
authors: L
authors: Zhu
authors: Department of Cardiology, Afﬁliated Hospital of North Sichuan Medical College, Nanchong, Sichuan Province, P.R. China.
authors: Zhan
authors: Z
authors: Lu
authors: Department of Clinical Medicine, North Sichuan Medical College, Nanchong, Sichuan Province, P.R. China.
authors: Liren
authors: L
authors: Zhu
authors: Department of Clinical Medicine, North Sichuan Medical College, Nanchong, Sichuan Province, P.R. China.
authors: Xiaoxiao
authors: X
authors: Ouyang
authors: Department of Clinical Medicine, North Sichuan Medical College, Nanchong, Sichuan Province, P.R. China.
authors: Yang
authors: Y
authors: Yang
authors: Department of Clinical Medicine, North Sichuan Medical College, Nanchong, Sichuan Province, P.R. China.
authors: Yanping
authors: Y
authors: Feng
authors: Department of Clinical Medicine, North Sichuan Medical College, Nanchong, Sichuan Province, P.R. China.
authors: Ping
authors: P
authors: Li
authors: Department of Clinical Medicine, North Sichuan Medical College, Nanchong, Sichuan Province, P.R. China.
authors: Wenjing
authors: W
authors: Ye
authors: Sichuan Key Laboratory of Medical Imaging and Department of Radiology, Afﬁliated Hospital of North Sichuan Medical College, Nanchong, Sichuan Province, P.R. China.
authors: Xiaoming
authors: X
authors: Zhang
authors: Department of Medical Biochemistry, North Sichuan Medical College, Nanchong, Sichuan Province, P.R. China.
authors: Xiuyun
authors: X
authors: Zhang
authors: Department of Medical Biochemistry, North Sichuan Medical College, Nanchong, Sichuan Province, P.R. China.
authors: Yongyan
authors: Y
authors: Song
mesh_terms: D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D003430:Cross-Sectional Studies; D006801:Humans; D017270:Lipoprotein(a) / Q000097:blood*; D012307:Risk Factors; D014280:Triglycerides
chemical_list: D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D017270:Lipoprotein(a); D014280:Triglycerides
keywords: Gensini score; Lipoprotein(a); coronary heart disease; lipid; severity