title: Serum Macroelement and Microelement Concentrations in Patients with Polycystic Ovary Syndrome: a Cross-Sectional Study.
abstract: Polycystic ovarian syndrome (PCOS) is one of the most common endocrine diseases. However, its pathogenesis is unclear. We aim to explore the potential relationships between serum macroelements/microelements and PCOS. A total of 1137 women were involved in the current study. PCOS was defined according to ESHRE/ASRM, and complete blood samples were collected. Serum macroelements (calcium and magnesium) and microelements (copper, zinc, and iron) were assayed through atomic absorption spectrophotometry. PCOS patients had significantly higher copper concentrations than patients without PCOS (P < 0.001). By contrast, PCOS patients had lower serum calcium levels than patients without PCOS (P < 0.001). No significant differences were observed in the levels of serum zinc, magnesium, and iron between PCOS and non-PCOS patients. PCOS patients with acne had higher magnesium levels than those without acne (P = 0.020), and PCOS patients with hirsutism had lower magnesium levels than those without hirsutism (P = 0.037). High serum copper and low calcium levels may be correlated with PCOS. Magnesium concentrations are correlated with acne and hirsutism in PCOS patients. These results provide clues to explore the mechanism of PCOS and guidance for element treatments in PCOS patients.
authors: Experimental Centre of Medical Sciences, Guangxi Medical University, Nanning, Guangxi, 530000, China.
authors: Muyan
authors: M
authors: Li
authors: Guangxi Reproductive Medical Research Center, First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China.
authors: Yuanyuan
authors: Y
authors: Tang
authors: Experimental Centre of Medical Sciences, Guangxi Medical University, Nanning, Guangxi, 530000, China.
authors: Chunlei
authors: C
authors: Lin
authors: Experimental Centre of Medical Sciences, Guangxi Medical University, Nanning, Guangxi, 530000, China.
authors: Qiaoying
authors: Q
authors: Huang
authors: Experimental Centre of Medical Sciences, Guangxi Medical University, Nanning, Guangxi, 530000, China. ldq0422@126.com.
authors: Danqing
authors: D
authors: Lei
authors: Experimental Centre of Medical Sciences, Guangxi Medical University, Nanning, Guangxi, 530000, China. ylhuteam@163.com.|Center for Genomic and Personalized Medicine, Guangxi Medical University, Nanning, Guangxi, China. ylhuteam@163.com.|Guangxi Colleges and Universities Key Laboratory of Biological Molecular Medicine Research, Guangxi Medical University, Nanning, Guangxi, China. ylhuteam@163.com.
authors: Yanling
authors: Y
authors: Hu
mesh_terms: D000152:Acne Vulgaris / Q000097:blood; D000328:Adult; D002118:Calcium / Q000097:blood*; D003300:Copper / Q000097:blood*; D003430:Cross-Sectional Studies; D005260:Female; D006628:Hirsutism / Q000097:blood; D006801:Humans; D007501:Iron / Q000097:blood*; D016015:Logistic Models; D008274:Magnesium / Q000097:blood*; D011085:Polycystic Ovary Syndrome / Q000097:blood*; D013054:Spectrophotometry, Atomic; D011795:Surveys and Questionnaires; D015032:Zinc / Q000097:blood*
chemical_list: D003300:Copper; D007501:Iron; D008274:Magnesium; D015032:Zinc; D002118:Calcium
keywords: Acne; Copper and zinc; Hirsutism; Infertility; Polycystic ovary syndrome