title: Measuring serum matrix metalloproteinase-9 levels in peripheral blood after subarachnoid hemorrhage to predict cerebral vasospasm.
abstract: OBJECTIVE
  We aimed to investigate serum levels of matrix metalloproteinase-9 in both subarachnoid hemorrhage and control groups for prediction of cerebral vasospasm in this study.
  
  
  METHODS
  Venous serum matrix metalloproteinase-9 levels were prospectively measured four times (days 1, 3, 7, and 14) for 34 consecutive patients with subarachnoidal hemorrhage (n = 27) and for elective aneurysm clipping (control, n = 7).
  
  
  RESULTS
  Vasospasm developed in 11/34 (32.4 %) patients between 3 and 10 days after subarachnoid hemorrhage (median 5.58 days), mean peak serum matrix metalloproteinase-9 compared with the non-vasospasm cohort. Matrix metalloproteinase-9 levels were higher in subarachnoid hemorrhage patients than in the controls.
  
  
  CONCLUSIONS
  Increased serum matrix metalloproteinase-9 could be an accurate biomarker to predict the onset of cerebral vasospasm after subarachnoid hemorrhage.
authors: Department of Neurosurgery, Adiyaman University Education and Research Hospital, 02200 Adiyaman, Turkey.
authors: Aykut
authors: A
authors: Akpinar
authors: Department of Neurosurgery, Adiyaman University Education and Research Hospital, 02200 Adiyaman, Turkey.
authors: Necati
authors: N
authors: Ucler
authors: Bakirkoy Research and Training Hospital for Neurology Neurosurgery and Psychiatry, Istanbul, Turkey.
authors: Uzay
authors: U
authors: Erdogan
authors: Department of Neurosurgery, Mcknight Brain Institute, University of Florida, Gainesville, FL USA.
authors: Serhat S
authors: SS
authors: Baydin
authors: Department of Neurosurgery, Mcknight Brain Institute, University of Florida, Gainesville, FL USA.
authors: Abuzer
authors: A
authors: Gungor
authors: Bakirkoy Research and Training Hospital for Neurology Neurosurgery and Psychiatry, Istanbul, Turkey.
authors: Bekir
authors: B
authors: Tugcu
keywords: Aneurysm; Ischemia; Matrix metalloproteinase-9; Subarachnoid hemorrhage