title: Microwave-Assisted Syntheses of Bioactive Seven-Membered, Macro-Sized Heterocycles and Their Fused Derivatives.
abstract: This review describes the recent advances in the microwave-assisted synthesis of 7-membered and larger heterocyclic compounds. Several types of reaction for the cyclization step are discussed: Ring Closing Metathesis (RCM), Heck and Sonogashira reactions, Suzuki-Miyaura cross-coupling, dipolar cycloadditions, multi-component reactions (Ugi, Passerini), etc. Green syntheses and solvent-free procedures have been introduced whenever possible. The syntheses discussed herein have been selected to illustrate the huge potential of microwave in the synthesis of highly functionalized molecules with potential therapeutic applications, in high yields, enhanced reaction rates and increased chemoselectivity, compared to conventional methods. More than 100 references from the recent literature are listed in this review.
authors: Laboratoire de Chimie des Plantes et de Synthèse Organique et Bioorganique, URAC23, Faculté des Sciences, Université Mohammed V, B.P. 1014 Rabat, Maroc. m.driowya@hotmail.com.
authors: Mohsine
authors: M
authors: Driowya
authors: Laboratoire de Chimie des Plantes et de Synthèse Organique et Bioorganique, URAC23, Faculté des Sciences, Université Mohammed V, B.P. 1014 Rabat, Maroc. aziza.saber@ymail.com.
authors: Aziza
authors: A
authors: Saber
authors: Laboratoire de Chimie des Plantes et de Synthèse Organique et Bioorganique, URAC23, Faculté des Sciences, Université Mohammed V, B.P. 1014 Rabat, Maroc. marzaghamid@gmail.com.
authors: Hamid
authors: H
authors: Marzag
authors: Institut de Chimie de Nice, ICN UMR UNS CNRS 7272, Université Nice-Sophia Antipolis-Université Côte d'Azur, Parc Valrose, 06108 Nice Cedex 2, France. luc.demange@unice.fr.|Département de Chimie, Université Paris Descartes, Sorbonne Paris Cité, UFR des Sciences Pharmaceutiques, 4 avenue de l'Observatoire & UFR Biomédicale des Saints Pères, 45 Rue des Saints Pères, Paris Fr-75006, France. luc.demange@unice.fr.
authors: Luc
authors: L
authors: Demange
authors: Laboratoire de Chimie des Plantes et de Synthèse Organique et Bioorganique, URAC23, Faculté des Sciences, Université Mohammed V, B.P. 1014 Rabat, Maroc. kbougrin@yahoo.fr.
authors: Khalid
authors: K
authors: Bougrin
authors: Institut de Chimie de Nice, ICN UMR UNS CNRS 7272, Université Nice-Sophia Antipolis-Université Côte d'Azur, Parc Valrose, 06108 Nice Cedex 2, France. rachid.benhida@unice.fr.
authors: Rachid
authors: R
authors: Benhida
mesh_terms: D006571:Heterocyclic Compounds / Q000138:chemical synthesis* / Q000737:chemistry*; D008872:Microwaves
chemical_list: D006571:Heterocyclic Compounds
keywords: bioactive molecules; cyclocondensations; dipolar cycloaddition; microwave irradiation; multicomponent reactions