title: Effects of Immunosuppressive Drugs on Serum Fatty Acids of Phospholipids Fraction in Renal Transplant Recipients.
abstract: BACKGROUND
  Immunosuppressive medications often cause posttransplant hyperlipidemia. The effects of cyclosporine (CsA) and tacrolimus (Tac) on lipid profile is well-known; however, there are very few studies related to the effect of these immunosuppressants on fatty acids (FA) of phosholipids fraction (PL) in renal transplant recipients (RTR). We sought to analyze the FA profile in PL fraction of RTR treated with Tac or CsA.
  
  
  METHODS
  The study included 65 renal transplant patients on CsA (n = 24, group I) or Tac (n = 41, group II), and 14 healthy controls. Individual serum FA concentrations were measured by gas chromatography. Chemstation software was used to analyze the data.
  
  
  RESULTS
  No differences between studied groups and controls were noted for monounsaturated FA, polyunsaturated n-3 FA (PUFA n-3), PUFA n-6, or the ratio of PUFA n-6 to PUFA n-3. The following mean values of FA were significantly higher in the CsA-RTR and Tac-RTR as compared with controls: total FA (P < .01 in both cases), saturated FA (SFA; P < .02 in both cases), C12 (P < .003 in both cases), C18 (P < .003 in both cases), and C18:2 (P < .01 for CsA RTR; P < .02 for Tac RTR). No differences between the measurements in patients on CsA and in patients on Tac were noticed. Significant correlation between SFA and eGFR was observed only in the CsA RTR group (P < .05). A negative relationship between PUFA n-6 and the estimated glomerular filtration rate was seen, but the correlation was not significant.
  
  
  CONCLUSIONS
  Immunosuppressive drugs may affect FA metabolism, but the FA profile does not depend on the type of immunosuppressive drug administered.
authors: Department of Clinical Biochemistry, Jagiellonian University Medical College, Cracow, Poland. Electronic address: malgorzata.wilusz@gmail.com.
authors: M
authors: M
authors: Wilusz
authors: Department of Nephrology, Jagiellonian University Medical College, Cracow, Poland.
authors: D
authors: D
authors: Cieniawski
authors: Department of Clinical Biochemistry, Jagiellonian University Medical College, Cracow, Poland.
authors: J
authors: J
authors: Bugajska
authors: Department of Clinical Biochemistry, Jagiellonian University Medical College, Cracow, Poland.
authors: J
authors: J
authors: Berska
authors: Department of Nephrology, Jagiellonian University Medical College, Cracow, Poland.
authors: E
authors: E
authors: Ignacak
authors: Department of Nephrology, Jagiellonian University Medical College, Cracow, Poland.
authors: A
authors: A
authors: Bętkowska-Prokop
authors: Department of Nephrology, Jagiellonian University Medical College, Cracow, Poland.
authors: M
authors: M
authors: Kuźniewski
authors: Department of Nephrology, Jagiellonian University Medical College, Cracow, Poland.
authors: W
authors: W
authors: Sułowicz
authors: Department of Clinical Biochemistry, Jagiellonian University Medical College, Cracow, Poland.
authors: K
authors: K
authors: Sztefko
mesh_terms: D000328:Adult; D016572:Cyclosporine / Q000627:therapeutic use; D005227:Fatty Acids / Q000097:blood*; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D010743:Phospholipids / Q000097:blood; D016559:Tacrolimus / Q000627:therapeutic use; D055815:Young Adult
chemical_list: D005227:Fatty Acids; D007166:Immunosuppressive Agents; D010743:Phospholipids; D016572:Cyclosporine; D016559:Tacrolimus