title: The Significance of the Default Mode Network (DMN) in Neurological and Neuropsychiatric Disorders: A Review.
abstract: The relationship of cortical structure and specific neuronal circuitry to global brain function, particularly its perturbations related to the development and progression of neuropathology, is an area of great interest in neurobehavioral science. Disruption of these neural networks can be associated with a wide range of neurological and neuropsychiatric disorders. Herein we review activity of the Default Mode Network (DMN) in neurological and neuropsychiatric disorders, including Alzheimer's disease, Parkinson's disease, Epilepsy (Temporal Lobe Epilepsy - TLE), attention deficit hyperactivity disorder (ADHD), and mood disorders. We discuss the implications of DMN disruptions and their relationship to the neurocognitive model of each disease entity, the utility of DMN assessment in clinical evaluation, and the changes of the DMN following treatment.
authors: Baylor College of Medicine, Houston, Texas.
authors: Akansha
authors: A
authors: Mohan
authors: Clinical fellow, Child and Adolescent Psychiatry, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts.
authors: Aaron J
authors: AJ
authors: Roberto
authors: Old Dominion University, Norfolk, Virginia.
authors: Abhishek
authors: A
authors: Mohan
authors: Resident physician, Adult Psychiatry, Westchester Medical Center, New York Medical College, Westchester, New York.
authors: Aileen
authors: A
authors: Lorenzo
authors: Clinical fellow, Child and Adolescent Psychiatry, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts.
authors: Kathryn
authors: K
authors: Jones
authors: Tulane University School of Medicine, New Orleans, Louisianna.
authors: Martin J
authors: MJ
authors: Carney
authors: Neurosurgery resident physician, Department of Neurosurgery, Medical University of South Carolina, Charleston, South Carolina.
authors: Luis
authors: L
authors: Liogier-Weyback
authors: University of Nebraska Medical Center, Omaha, Nebraska.
authors: Soonjo
authors: S
authors: Hwang
authors: Northwell Health, Zucker Hillside Hospital, Glen Oaks, New York.
authors: Kyle A B
authors: KA
authors: Lapidus
mesh_terms: D000544:Alzheimer Disease / Q000378:metabolism* / Q000503:physiopathology; D000818:Animals; D001289:Attention Deficit Disorder with Hyperactivity / Q000378:metabolism* / Q000503:physiopathology; D001931:Brain Mapping; D004833:Epilepsy, Temporal Lobe / Q000378:metabolism* / Q000503:physiopathology; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D019964:Mood Disorders / Q000378:metabolism* / Q000503:physiopathology
keywords: Alzheimer’s disease; Default Mode Network; Parkinson’s disease; Resting State Functional Magnetic Resonance Imaging; Temporal Lobe Epilepsy; attention deficit hyperactivity disorder; mood disorder