title: Audio-visual speech perception in infants and toddlers with Down syndrome, fragile X syndrome, and Williams syndrome.
abstract: Typically-developing (TD) infants can construct unified cross-modal percepts, such as a speaking face, by integrating auditory-visual (AV) information. This skill is a key building block upon which higher-level skills, such as word learning, are built. Because word learning is seriously delayed in most children with neurodevelopmental disorders, we assessed the hypothesis that this delay partly results from a deficit in integrating AV speech cues. AV speech integration has rarely been investigated in neurodevelopmental disorders, and never previously in infants. We probed for the McGurk effect, which occurs when the auditory component of one sound (/ba/) is paired with the visual component of another sound (/ga/), leading to the perception of an illusory third sound (/da/ or /tha/). We measured AV integration in 95 infants/toddlers with Down, fragile X, or Williams syndrome, whom we matched on Chronological and Mental Age to 25 TD infants. We also assessed a more basic AV perceptual ability: sensitivity to matching vs. mismatching AV speech stimuli. Infants with Williams syndrome failed to demonstrate a McGurk effect, indicating poor AV speech integration. Moreover, while the TD children discriminated between matching and mismatching AV stimuli, none of the other groups did, hinting at a basic deficit or delay in AV speech processing, which is likely to constrain subsequent language development.
authors: Centre for Brain and Cognitive Development, Department of Psychological Sciences, Birkbeck, University of London, London, UK.
authors: Dean
authors: D
authors: D'Souza
authors: Centre for Brain and Cognitive Development, Department of Psychological Sciences, Birkbeck, University of London, London, UK; Department of Experimental Psychology, University of Oxford, Oxford, UK.
authors: Hana
authors: H
authors: D'Souza
authors: Centre for Brain and Cognitive Development, Department of Psychological Sciences, Birkbeck, University of London, London, UK.
authors: Mark H
authors: MH
authors: Johnson
authors: Centre for Brain and Cognitive Development, Department of Psychological Sciences, Birkbeck, University of London, London, UK. Electronic address: a.karmiloff-smith@bbk.ac.uk.
authors: Annette
authors: A
authors: Karmiloff-Smith
mesh_terms: D002657:Child Development / Q000502:physiology*; D002675:Child, Preschool; D003463:Cues; D004314:Down Syndrome / Q000503:physiopathology*; D005260:Female; D005600:Fragile X Syndrome / Q000503:physiopathology*; D006801:Humans; D007223:Infant; D007804:Language Development; D008297:Male; D013067:Speech Perception / Q000502:physiology*; D014706:Verbal Learning; D014796:Visual Perception / Q000502:physiology*; D018980:Williams Syndrome / Q000503:physiopathology*
keywords: Audio-visual speech integration; Down syndrome; Language acquisition; Williams syndrome; fragile X syndrome; the McGurk effect