title: MicroRNA-106b targets FUT6 to promote cell migration, invasion, and proliferation in human breast cancer.
abstract: It is demonstrated that the maladjustment of microRNA (miRNA) plays significant roles in the occurrence and development of tumors. MicroRNA-106b-5p (miR-106b), a carcinogenic miRNA, is identified as a dysregulated miRNA in human breast cancer. In this article, the expression levels of miR-106b were discovered to be particularly higher in breast cancer tissues than that in the corresponding adjacent tissues. Accordingly, miR-106b was higher expressed in the breast cancer cell lines compared with that in the normal breast cell lines. Moreover, according to the data previously reported, increased expression of miR-106b was significantly associated with advanced clinical stages and poor prognosis in breast cancer. Fucosyltransferase 6 (FUT6), a member of the fucosyltransferase (FUT) family, was found to have a reduced expression in tissues or cells with higher level of miR-106b in breast cancer. Additionally, down-regulation of miR-106b increased the expression of FUT6 and resulted in an obvious decrease of cell migration, invasion, and proliferation in MDA-MB-231 cells. Furthermore, over-expressed FUT6 reversed the impacts of up-regulated miR-106b on cell migration, invasion, and proliferation in MCF-7 cells, indicating that FUT6 might be directly targeted by miR-106b and serve as therapeutic targets for breast cancer. In brief, our results strongly showed that the low expression of FUT6 regulated by miR-106b contributed to cell migration, invasion, and proliferation in human breast cancer. © 2016 IUBMB Life, 68(9):764-775, 2016.
authors: College of Laboratory Medicine, Dalian Medical University, Dalian, Liaoning Province, 116044, China.
authors: Nana
authors: N
authors: Li
authors: Department of Central Laboratory, the First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning Province, 116011, China.
authors: Yuejian
authors: Y
authors: Liu
authors: College of Laboratory Medicine, Dalian Medical University, Dalian, Liaoning Province, 116044, China.
authors: Yuan
authors: Y
authors: Miao
authors: College of Laboratory Medicine, Dalian Medical University, Dalian, Liaoning Province, 116044, China.
authors: Lifen
authors: L
authors: Zhao
authors: Department of Microbiology, Dalian Medical University, Dalian, Liaoning Province, 116044, China.
authors: Huimin
authors: H
authors: Zhou
authors: College of Laboratory Medicine, Dalian Medical University, Dalian, Liaoning Province, 116044, China.
authors: Li
authors: L
authors: Jia
mesh_terms: D001943:Breast Neoplasms / Q000235:genetics* / Q000473:pathology; D063646:Carcinogenesis / Q000235:genetics*; D002465:Cell Movement / Q000235:genetics; D049109:Cell Proliferation / Q000235:genetics; D005260:Female; D005647:Fucosyltransferases / Q000235:genetics*; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D061986:MCF-7 Cells; D035683:MicroRNAs / Q000235:genetics*; D009361:Neoplasm Invasiveness / Q000235:genetics
chemical_list: C542541:MIRN106 microRNA, human; D035683:MicroRNAs; D005647:Fucosyltransferases; C515956:FUT6 protein, human
keywords: FUT6; breast cancer; invasion; microRNA-106b; migration; proliferation