title: Formulation and dissolution kinetics study of hydrophilic matrix tablets with tramadol hydrochloride and different co-processed dry binders.
abstract: The aim of this study is to present the possibility of using of co-processed dry binders for formulation of matrix tablets with drug controlled release. Hydrophilic matrix tablets with tramadol hydrochloride, hypromellose and different co-processed dry binders were prepared by direct compression method. Hypromelloses Methocel™ K4M Premium CR or Methocel™ K100M Premium CR were used as controlled release agents and Prosolv® SMCC 90 or Disintequik™ MCC 25 were used as co-processed dry binders. Homogeneity of the tablets was evaluated using scanning electron microscopy and energy dispersive X-ray microanalysis. The release of tramadol hydrochloride from prepared formulations was studied by dissolution test method. The dissolution profiles obtained were evaluated by non-linear regression analysis, release rate constants and other kinetic parameters were determined. It was found that matrix tablets based on Prosolv® SMCC 90 and Methocel™ Premium CR cannot control the tramadol release effectively for >12h and tablets containing Disintequik™ MCC 25 and Methocel™ Premium CR >8h.
authors: Department of Physical Chemistry, Faculty of Chemical Technology, University of Pardubice, Studentská 573, 532 10 Pardubice, Czech Republic.
authors: Alena
authors: A
authors: Komersová
authors: Department of Physical Chemistry, Faculty of Chemical Technology, University of Pardubice, Studentská 573, 532 10 Pardubice, Czech Republic. Electronic address: vaclav.lochar@upce.cz.
authors: Václav
authors: V
authors: Lochař
authors: Department of Physical Chemistry, Faculty of Chemical Technology, University of Pardubice, Studentská 573, 532 10 Pardubice, Czech Republic.
authors: Kateřina
authors: K
authors: Myslíková
authors: Department of Pharmaceutical Technology, Charles University in Prague, Faculty of Pharmacy in Hradec Králové, Heyrovského 1203, 500 05 Hradec Králové, Czech Republic.
authors: Jitka
authors: J
authors: Mužíková
authors: Department of Analytical Chemistry, Faculty of Chemical Technology, University of Pardubice, Studentská 573, 532 10 Pardubice, Czech Republic.
authors: Martin
authors: M
authors: Bartoš
mesh_terms: D002626:Chemistry, Pharmaceutical / Q000379:methods*; D065546:Drug Liberation; D057927:Hydrophobic and Hydrophilic Interactions; D065347:Hypromellose Derivatives / Q000737:chemistry* / Q000493:pharmacokinetics*; D012995:Solubility; D013607:Tablets; D014147:Tramadol / Q000737:chemistry* / Q000493:pharmacokinetics*
chemical_list: D013607:Tablets; D014147:Tramadol; D065347:Hypromellose Derivatives
keywords: Co-processed dry binders; Dissolution kinetics; Hypromellose; Matrix tablets; Tramadol hydrochloride