title: Mosaic tetracycline resistance genes encoding ribosomal protection proteins.
abstract: First reported in 2003, mosaic tetracycline resistance genes are a subgroup of the genes encoding ribosomal protection proteins (RPPs). They are formed when two or more RPP-encoding genes recombine resulting in a functional chimera. To date, the majority of mosaic genes are derived from sections of three RPP genes, tet(O), tet(W) and tet(32), with others comprising tet(M) and tet(S). In this first review of mosaic genes, we report on their structure, diversity and prevalence, and suggest that these genes may be responsible for an under-reported contribution to tetracycline resistance in bacteria.
authors: School of Biomedical and Healthcare Sciences, Plymouth University Peninsula Schools of Medicine and Dentistry, School of Biomedical and Healthcare Services, Plymouth, UK philip.warburton@plymouth.ac.uk.
authors: Philip J
authors: PJ
authors: Warburton
authors: Department of Biomedical and Forensic Science, Faculty of Science and Technology, Anglia Ruskin University, Cambridge, UK.
authors: Nina
authors: N
authors: Amodeo
authors: Department of Microbial Diseases, UCL Eastman Dental Institute, University College London, London, UK.
authors: Adam P
authors: AP
authors: Roberts
mesh_terms: D000818:Animals; D001419:Bacteria / Q000187:drug effects* / Q000235:genetics*; D001426:Bacterial Proteins / Q000235:genetics* / Q000378:metabolism; D005798:Genes, Bacterial; D006801:Humans; D011994:Recombinant Proteins / Q000235:genetics* / Q000378:metabolism; D013753:Tetracycline Resistance
chemical_list: D001426:Bacterial Proteins; D011994:Recombinant Proteins