title: [Retrospective study of neuromeningeal cryptococcosis in patients infected with HIV in the infectious diseases unit of university hospital of Casablanca, Morocco].
abstract: OBJECTIVE
  To report the cases of neuromeningeal cryptococcosis and to describe the clinical, paraclinical, therapeutic and outcomes of patients.
  
  
  METHODS
  Retrospective study of 43 patients infected with HIV admitted from January first 2010 to June 30th 2015 in the infectious disease unit of UHC Ibn Rochd, for neuromeningeal cryptococcus.
  
  
  RESULTS
  The mean frequency of neuromeningeal cryptococcosis in patients infected with HIV was 1.4%. The mean age was 39 years and a sex ratio of 1.38. The mean CD4 count was 70 cells/mm3. The diagnosis of HIV was revealed by neuromeningeal cryptococcus in 77% of cases. Fifteen days interval was reported between the first symptom and hospital admission. Headache (77%) was the most represented clinical sign. The cerebrospinal fluid analysis showed hypoglycorachy (67%), hyperproteinorachy (65%) and lymphocytosis (63%). Chinese ink direct examination for Cryptococcus neoformans in CSF was positive in 86% of cases and all cases were positive after culture on Sabouraud's medium. Patients were treated with monotherapy amphotericin B (42%) or fluconazole (28%) and bitherapy amphotéricine B/fluconazole (28%). Fatal evolution was observed in 60% of cases.
  
  
  CONCLUSIONS
  Neuromeningeal cryptococcosis remains a severe opportunistic infection in HIV patients with a heavy mortality rate.
authors: Service des maladies infectieuses, CHU Ibn Rochd, Casablanca, Maroc. Electronic address: ibrahimdollo24@yahoo.fr.
authors: I
authors: I
authors: Dollo
authors: Service des maladies infectieuses, CHU Ibn Rochd, Casablanca, Maroc.
authors: L
authors: L
authors: Marih
authors: Service des maladies infectieuses, CHU Ibn Rochd, Casablanca, Maroc.
authors: M
authors: M
authors: El Fane
authors: Service des maladies infectieuses, CHU Ibn Rochd, Casablanca, Maroc.
authors: M
authors: M
authors: Es-Sebbani
authors: Service des maladies infectieuses, CHU Ibn Rochd, Casablanca, Maroc.
authors: M
authors: M
authors: Sodqi
authors: Service des maladies infectieuses, CHU Ibn Rochd, Casablanca, Maroc.
authors: A
authors: A
authors: Oulad Lahsen
authors: Service des maladies infectieuses, CHU Ibn Rochd, Casablanca, Maroc.
authors: A
authors: A
authors: Chakib
authors: Laboratoire de parasitologie-mycologie, CHU Ibn Rochd, Casablanca, Maroc.
authors: F
authors: F
authors: El Kadioui
authors: Laboratoire de parasitologie-mycologie, CHU Ibn Rochd, Casablanca, Maroc.
authors: A
authors: A
authors: Hamdani
authors: Laboratoire de parasitologie-mycologie, CHU Ibn Rochd, Casablanca, Maroc.
authors: M J
authors: MJ
authors: El Mabrouki
authors: Laboratoire de parasitologie-mycologie, CHU Ibn Rochd, Casablanca, Maroc.
authors: M
authors: M
authors: Soussi Abdallaoui
authors: Laboratoire d'épidémiologie, FACULTE de médecine de pharmacie de Casablanca, Casablanca, Maroc.
authors: Z
authors: Z
authors: Karima
authors: Laboratoire d'épidémiologie, FACULTE de médecine de pharmacie de Casablanca, Casablanca, Maroc.
authors: S
authors: S
authors: Hassoune
authors: Laboratoire d'épidémiologie, FACULTE de médecine de pharmacie de Casablanca, Casablanca, Maroc.
authors: A
authors: A
authors: Maaroufi
authors: Service des maladies infectieuses, CHU Ibn Rochd, Casablanca, Maroc.
authors: K
authors: K
authors: Marhoum El Filali
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000188:drug therapy* / Q000453:epidemiology* / Q000382:microbiology; D000328:Adult; D000666:Amphotericin B / Q000627:therapeutic use*; D000935:Antifungal Agents / Q000627:therapeutic use; D003455:Cryptococcus neoformans / Q000472:pathogenicity; D005260:Female; D015658:HIV Infections / Q000150:complications / Q000188:drug therapy* / Q000453:epidemiology*; D015497:HIV-1; D006760:Hospitalization / Q000706:statistics & numerical data; D006785:Hospitals, University; D006801:Humans; D015994:Incidence; D008297:Male; D016919:Meningitis, Cryptococcal / Q000150:complications / Q000188:drug therapy* / Q000453:epidemiology*; D008875:Middle Aged; D009018:Morocco / Q000453:epidemiology; D012189:Retrospective Studies; D016019:Survival Analysis
chemical_list: D000935:Antifungal Agents; D000666:Amphotericin B
keywords: Amphotericin B; Amphotéricine B; Cryptococcose neuroméningée; HIV infection; Neuromeningeal cryptococcosis; VIH/sida