title: Comparative efficacy of oral nucleotide analogues for the prophylaxis of hepatitis B virus recurrence after liver transplantation: a network meta-analysis.
abstract: Prophylactic nucleos(t)ide anologues against hepatitis B virus (HBV) recurrence after liver transplantation (LT) include lamivudine, entecavir, tenofovir, adefovir. Since the most effective strategies for post-LT remain inconclusive, we aimed to compare 6 different treatment options (lamivudine, entecavir, tenofovir, adefovir, lamivudine plus adefovir, lamivudine plus tenofovir) in terms of HBV recurrence after LT using network meta-analysis.
  
  
  
  The search identified seventeen studies involving 6 different prophylactic regimens covering 7274 patients.
  
  
  
  Compared with entecavir, lamivudine plus tenofovir (OR 2.00, 95%CI 0.02-183.29), lamivudine plus adefovir, (OR 2.83, 95%CI 0.18-33.57), tenofovir (OR 1.11, 95%CI 0.22-5.80), adefovir (OR 3.78, 95%CI 0.59-22.16), lamivudine (OR 4.62, 95%CI 1.75-11.39) were associated with an increased risk of HBV recurrence.
  
  
  
  Entecavir resulted with the highest probability (31%) as the best prophylactic option on reducing the risk of HBV recurrence. Entecavir is the preferred oral NAs treatment compared to other five different prophylactic regimens in the prevention of HBV recurrence after LT.
authors: a Department of Hepatology, Liver Research Center , the First Affiliated Hospital of Wenzhou Medical University , Wenzhou , China.|b School of the First Clinical Medical Sciences , Wenzhou Medical University , Wenzhou , China.
authors: Ji-Na
authors: JN
authors: Zheng
authors: a Department of Hepatology, Liver Research Center , the First Affiliated Hospital of Wenzhou Medical University , Wenzhou , China.|c School of the Second Clinical Medical Sciences , Wenzhou Medical University , Wenzhou , China.
authors: Tian-Tian
authors: TT
authors: Zou
authors: d Department of Infection Diseases , Zhejiang Provincial People's Hospital , Hangzhou , China.
authors: Hai
authors: H
authors: Zou
authors: a Department of Hepatology, Liver Research Center , the First Affiliated Hospital of Wenzhou Medical University , Wenzhou , China.|b School of the First Clinical Medical Sciences , Wenzhou Medical University , Wenzhou , China.
authors: Gui-Qi
authors: GQ
authors: Zhu
authors: a Department of Hepatology, Liver Research Center , the First Affiliated Hospital of Wenzhou Medical University , Wenzhou , China.|b School of the First Clinical Medical Sciences , Wenzhou Medical University , Wenzhou , China.
authors: Lu-Yi
authors: LY
authors: Ruan
authors: a Department of Hepatology, Liver Research Center , the First Affiliated Hospital of Wenzhou Medical University , Wenzhou , China.|b School of the First Clinical Medical Sciences , Wenzhou Medical University , Wenzhou , China.
authors: Zhang
authors: Z
authors: Cheng
authors: e Department of Anesthesiology, Intensive Care, Emergency Medicine and Pain Therapy , Ziekenhuis Oost-Limburg , Genk , Belgium.
authors: Sven
authors: S
authors: Van Poucke
authors: a Department of Hepatology, Liver Research Center , the First Affiliated Hospital of Wenzhou Medical University , Wenzhou , China.|f Institute of Hepatology , Wenzhou Medical University , Wenzhou , China.
authors: Ming-Hua
authors: MH
authors: Zheng
mesh_terms: D000998:Antiviral Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D001499:Bayes Theorem; D002986:Clinical Trials as Topic; D006147:Guanine / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use; D006515:Hepatitis B virus / Q000187:drug effects* / Q000302:isolation & purification; D019694:Hepatitis B, Chronic / Q000517:prevention & control* / Q000821:virology; D006801:Humans; D016031:Liver Transplantation; D012008:Recurrence; D055502:Secondary Prevention
chemical_list: D000998:Antiviral Agents; C413685:entecavir; D006147:Guanine
keywords: Hepatitis B virus recurrence; indirect comparison; liver transplantation; network meta-analysis; nucleos(t)ide analogues prophylaxis