title: KSHV non-structural membrane proteins involved in the activation of intracellular signaling pathways and the pathogenesis of Kaposi's sarcoma.
abstract: Kaposi's sarcoma (KS) is an unusual neoplasm characterized by extensive neoangiogenesis, infiltrates of inflammatory cells and atypically differentiated spindle cells of endothelial origin. KS is caused by an oncogenic γ-herpesvirus, Kaposi's sarcoma-associated herpesvirus (KSHV)/human herpesvirus-8 (HHV-8). Several KSHV proteins can subvert multiple cellular angiogenic, mitogenic and inflammatory pathways. Here, we discuss the KSHV encoded membrane proteins vGPCR, K1 and K15, with a particular emphasis on their activation of cellular signaling pathways and their role in the development of specific features of KS.
authors: Institute of Virology, Hannover Medical School, Carl Neuberg Strasse 1, 30625 Hannover, Germany; German Centre for Infection Research, Hannover-Braunschweig Site, Germany.
authors: Bizunesh
authors: B
authors: Abere
authors: Institute of Virology, Hannover Medical School, Carl Neuberg Strasse 1, 30625 Hannover, Germany; German Centre for Infection Research, Hannover-Braunschweig Site, Germany. Electronic address: schulz.thomas@mh-hannover.de.
authors: Thomas F
authors: TF
authors: Schulz
mesh_terms: D063646:Carcinogenesis; D019288:Herpesvirus 8, Human / Q000472:pathogenicity*; D006801:Humans; D019707:Receptors, Chemokine / Q000378:metabolism*; D012514:Sarcoma, Kaposi / Q000503:physiopathology*; D015398:Signal Transduction; D014764:Viral Proteins / Q000378:metabolism*
chemical_list: C115448:G protein-coupled receptor, Human herpesvirus 8; C111600:K1 protein, Human herpesvirus 8; C402642:K15 protein, Human herpesvirus 8; D019707:Receptors, Chemokine; D014764:Viral Proteins