title: Willingness to participate in health research: Tunisian survey.
abstract: Few studies have identified the willingness rate of developing countries population to be enrolled in clinical trials.
  
  
  
  All participants including patients (n = 612), healthy volunteers (n = 354) and doctors (n = 134) completed a questionnaire to examine factors affecting the consent to participate in medical research.
  
  
  
  Overall, 80 % of the included population agree to participate in health research. This rate was lower for trials dealing with life-threatening diseases (38 %). Altruism and perceived risk of harm were the main reason to respectively accept or refuse to participate in clinical trials. Factors significantly associated with willingness were: age <40 years (Odds Ratio (OR) 1.6 [95 % Confidence Interval (CI) 1.2-2.1]) and prior history of blood donation (OR 2.4 [95 % CI 1.7-3.5]).
  
  
  
  Most participants expressed their willingness to be included in medical research especially if they are young or if they have history of blood donation. However, consent to participate is low when medical research required acute care.
authors: Emergency Department, Fattouma Bourguiba University Hospital Monastir, Monastir, 5000, Tunisia.|Research Laboratory (LR12SP18), University of Monastir, Monastir, Tunisia.
authors: Wahid
authors: W
authors: Bouida
authors: Emergency Department, Fattouma Bourguiba University Hospital Monastir, Monastir, 5000, Tunisia.|Research Laboratory (LR12SP18), University of Monastir, Monastir, Tunisia.
authors: Mohamed Habib
authors: MH
authors: Grissa
authors: Emergency Department, Sahloul University Hospital, Sousse, Tunisia.
authors: Asma
authors: A
authors: Zorgati
authors: Emergency Department, Fattouma Bourguiba University Hospital Monastir, Monastir, 5000, Tunisia.|Research Laboratory (LR12SP18), University of Monastir, Monastir, Tunisia.
authors: Kaouthar
authors: K
authors: Beltaief
authors: Emergency Department, Fattouma Bourguiba University Hospital Monastir, Monastir, 5000, Tunisia.|Research Laboratory (LR12SP18), University of Monastir, Monastir, Tunisia.
authors: Hamdi
authors: H
authors: Boubaker
authors: Community Medicine Department, Fattouma Bourguiba University Hospital Monastir, Monastir, Tunisia.
authors: Asma
authors: A
authors: Sriha
authors: Emergency Department, Sahloul University Hospital, Sousse, Tunisia.|Research Laboratory (LR12SP18), University of Monastir, Monastir, Tunisia.
authors: Riadh
authors: R
authors: Boukef
authors: Emergency Department, Fattouma Bourguiba University Hospital Monastir, Monastir, 5000, Tunisia. Semir.nouira@rns.tn.|Research Laboratory (LR12SP18), University of Monastir, Monastir, Tunisia. Semir.nouira@rns.tn.
authors: Semir
authors: S
authors: Nouira
mesh_terms: D000328:Adult; D000367:Age Factors; D000533:Altruism; D018912:Arabs; D001290:Attitude; D035843:Biomedical Research; D003256:Community Participation; D003906:Developing Countries; D005260:Female; D064368:Healthy Volunteers; D006801:Humans; D007258:Informed Consent; D007514:Islam; D008297:Male; D008875:Middle Aged; D009042:Motivation; D010358:Patient Participation; D018579:Patient Selection; D010361:Patients; D035842:Research Subjects; D012306:Risk; D011795:Surveys and Questionnaires; D014416:Tunisia
keywords: Informed consent; Muslim community medical research; Patient participation