title: OTUD7B and NIK expression in non-small cell lung cancer: Association with clinicopathological features and prognostic implications.
abstract: OBJECTIVE
  To investigate the correlation among OTUD7B and NIK expression and the clinicopathological characteristics in NSCLC patients.
  
  
  METHODS
  One hundred and twenty patients were involved in this study. We detected OTUD7B and NIK expression by immunohistochemistry and analyzed their correlation with clinicopathological data.
  
  
  RESULTS
  The expression of OTUD7B and NIK were negatively correlated in NSCLC tumor samples (rs=-0.421, P<0.001). The higher expression of OTUD7B was associated with smaller tumor size(P=0.018), less lymph node metastasis (P=0.012) and earlier TNM stage(P=0.039), while the higher expression of NIK was only related to more lymph node metastasis(P=0.031) and later TNM stage(P=0.011). MMP-9 was negatively correlated with OTUD7B and positively correlated with NIK. In addition, the high expression of OTUD7B was associated with good prognosis of NSCLC patients (log-rank=6.714, P=0.0096), and a high OTUD7B/low NIK index can predict an even better prognosis (log-rank=11.794, P=0.0006). Moreover, the multivariate Cox regression analysis showed that OTUD7B rather than NIK is an independent marker of overall survival in NSCLC patients(HR=1.602, 95% CI 1.009-2.544, P=0.046).
  
  
  CONCLUSIONS
  OTUD7B and NIK may play important roles in the development of lung cancer. The combination of OTUD7B and NIK expression may be a good index for predicting the prognosis of NSCLC.
authors: Department Two of Thoracic Surgery, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, PR China.
authors: Boxiang
authors: B
authors: Zhang
authors: Department Two of Thoracic Surgery, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, PR China.
authors: Huangzhen
authors: H
authors: Wang
authors: Department Two of Thoracic Surgery, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, PR China.
authors: Litao
authors: L
authors: Yang
authors: Department Two of Thoracic Surgery, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, PR China.
authors: Yiwen
authors: Y
authors: Zhang
authors: Department Two of Thoracic Surgery, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, PR China.
authors: Peili
authors: P
authors: Wang
authors: Department Two of Thoracic Surgery, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, PR China.
authors: Guanghong
authors: G
authors: Huang
authors: Clinical Research Center,the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, PR China.
authors: Jie
authors: J
authors: Zheng
authors: Department Two of Thoracic Surgery, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, PR China. Electronic address: renhongs2000@gmail.com.
authors: Hong
authors: H
authors: Ren
authors: Department Two of Thoracic Surgery, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, PR China. Electronic address: sida.qin@yahoo.com.
authors: Sida
authors: S
authors: Qin
mesh_terms: D000368:Aged; D014408:Biomarkers, Tumor; D002289:Carcinoma, Non-Small-Cell Lung / Q000378:metabolism* / Q000401:mortality / Q000473:pathology; D010450:Endopeptidases / Q000378:metabolism*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008175:Lung Neoplasms / Q000378:metabolism* / Q000401:mortality / Q000473:pathology; D008207:Lymphatic Metastasis / Q000473:pathology*; D008297:Male; D009367:Neoplasm Staging; D011379:Prognosis; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism*; D015996:Survival Rate; D000097782:NF-kappaB-Inducing Kinase
chemical_list: D014408:Biomarkers, Tumor; D010450:Endopeptidases; D017346:Protein Serine-Threonine Kinases; D000097782:NF-kappaB-Inducing Kinase; C476458:OTUD7B protein, human
keywords: Lung cancer; NIK; OTUD7B; Prognosis; Survival