title: Tissue distribution of marbofloxacin in pigs after a single intramuscular injection.
abstract: Tissue distribution of marbofloxacin was studied in pigs after a single intramuscular injection at 2.5 mg/kg body weight. Samples of plasma, muscle, liver, kidney, heart, lung, and muscle at the injection site were randomly collected from five pigs at 2, 6, 10, 24, 48, 72, and 96 h after administration. Marbofloxacin concentrations were determined by using high-performance liquid chromatography with ultraviolet detection and were subjected to non-compartmental analysis to obtain kinetic parameters. The elimination half-life (t1/2λz) of marbofloxacin at the injection site was 22.12 h, while those in kidney, plasma, liver, lung, heart, and muscle were 16.75, 21.48, 21.84, 24.00, 24.45, and 28.91 h, respectively. Areas under the concentration-time curve from 0 h to ∞ (AUC0-∞s) were calculated to be 31.17 hㆍμgㆍmL-1for plasma and 32.97, 33.92, 34.78, 37.58, 42.02, and 98.80 hㆍμgㆍg-1for heart, muscle, lung, liver, kidney, and injection site, respectively. The peak concentration (Cmax) of marbofloxacin was 1.62 μg/mL in plasma and 1.71, 1.74, 1.86, 1.93, 2.45, and 7.64 μg/g in heart, lung, muscle, kidney, liver, and injection site, respectively. The results show that marbofloxacin was fast absorbed, extensively distributed, and slowly eliminated from pigs after a single intramuscular administration.
authors: College of Animal Science and Technology, Henan University of Science and Technology, Luoyang 471023, China.
authors: Fan
authors: F
authors: Yang
authors: Key Laboratory for Feed Biotechnology of the Ministry of Agriculture, Feed Research Institute, Chinese Academy of Agricultural Sciences, Beijing 10081, China.
authors: Yiming
authors: Y
authors: Liu
authors: College of Food and Bioengineering, Henan University of Science and Technology, Luoyang 471023, China.
authors: Zhili
authors: Z
authors: Li
authors: College of Animal Science and Technology, Henan University of Science and Technology, Luoyang 471023, China.
authors: Yuqin
authors: Y
authors: Wang
authors: College of Animal Science and Technology, Henan University of Science and Technology, Luoyang 471023, China.
authors: Baobao
authors: B
authors: Liu
authors: College of Animal Science and Technology, Henan University of Science and Technology, Luoyang 471023, China.
authors: Zhensheng
authors: Z
authors: Zhao
authors: College of Animal Science and Technology, Henan University of Science and Technology, Luoyang 471023, China.
authors: Bianhua
authors: B
authors: Zhou
authors: College of Animal Science and Technology, Henan University of Science and Technology, Luoyang 471023, China.
authors: Guoyong
authors: G
authors: Wang
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000032:analysis / Q000493:pharmacokinetics*; D002851:Chromatography, High Pressure Liquid / Q000662:veterinary; D024841:Fluoroquinolones / Q000008:administration & dosage / Q000032:analysis / Q000493:pharmacokinetics*; D007273:Injections, Intramuscular / Q000662:veterinary; D007668:Kidney / Q000737:chemistry; D008099:Liver / Q000737:chemistry; D008168:Lung / Q000737:chemistry; D008297:Male; D018482:Muscle, Skeletal / Q000737:chemistry; D009206:Myocardium / Q000737:chemistry; D013552:Swine / Q000378:metabolism
chemical_list: D000900:Anti-Bacterial Agents; D024841:Fluoroquinolones; C080260:marbofloxacin
keywords: kinetic parameters; marbofloxacin; pigs; tissue distribution