title: Voluntary running decreases nonexercise activity in lean and diet-induced obese mice.
abstract: Determine whether voluntary wheel running triggers compensatory changes in nonexercise activity in lean and high-fat diet fed mice.
  
  
  
  C57Bl/6 mice received a control (C) or a high-fat diet (H) and half of them had free access to a running wheel 5days/week (CE and HE, respectively) for 10weeks. Energy intake, nonexercise activity (global activity, distance covered and average speed of displacement in the home cage) and energy expenditure (EE) were evaluated at weeks 5 and 10 during the 2days without the wheels.
  
  
  
  High-fat diet increased weight gain in H (110%) and HE (60%) groups compared to C and CE groups, respectively, with no effect of exercise. Wheel running increased energy intake (26% CE, 11% HE in week 5; 7% CE, 45% HE in week 10) and decreased distance covered (26% for both CE and HE in week 5; 35% CE and 13% HE in week 10) and average speed (35% CE and 13% HE in week 5; 45% CE and 18% HE in week 10) compared to the respective nonexercised groups. In week 10 there was an interaction between diet and exercise for global activity, which was reduced nearly 18% in CE, H, and HE groups compared to C. Access to a running wheel increased EE in week 5 (11% CE and 16% HE) but not in week 10, which is consistent with the period of highest running (number of turns: weeks 1-5 nearly 100%>weeks 6-10 for CE and HE groups). EE was reduced in H (19%) and HE (12%) groups compared to C and CE, in week 10.
  
  
  
  Voluntary running causes a compensatory decrease in nonexercise activity and an increase in energy intake, both contributing to the lack of effect of exercise on body mass.
authors: Interdisciplinary Graduate Program in Health Sciences, Federal University of Sao Paulo, Santos, SP, Brazil.
authors: Francine Pereira
authors: FP
authors: de Carvalho
authors: Interdisciplinary Graduate Program in Health Sciences, Federal University of Sao Paulo, Santos, SP, Brazil.
authors: Izabelle Dias
authors: ID
authors: Benfato
authors: Interdisciplinary Graduate Program in Health Sciences, Federal University of Sao Paulo, Santos, SP, Brazil.
authors: Thaís Ludmilla
authors: TL
authors: Moretto
authors: Graduate Program in Food, Nutrition and Health, Federal University of Sao Paulo, Santos, SP, Brazil.
authors: Marcela
authors: M
authors: Barthichoto
authors: Department of Biosciences, Institute of Health and Society, Federal University of Sao Paulo, Santos, SP, Brazil. Electronic address: cam.oliveira@unifesp.br.
authors: Camila Aparecida Machado
authors: CA
authors: de Oliveira
mesh_terms: D000273:Adipose Tissue / Q000473:pathology; D000818:Animals; D001835:Body Weight / Q000502:physiology; D002151:Calorimetry; D059305:Diet, High-Fat / Q000009:adverse effects*; D004195:Disease Models, Animal; D002149:Energy Intake / Q000502:physiology; D004734:Energy Metabolism / Q000502:physiology*; D020738:Leptin / Q000378:metabolism; D051379:Mice; D008810:Mice, Inbred C57BL; D009765:Obesity / Q000209:etiology* / Q000503:physiopathology*; D010805:Physical Conditioning, Animal / Q000502:physiology*; D013997:Time Factors
chemical_list: D020738:Leptin
keywords: Compensation; Energy homeostasis; High-fat diet; Spontaneous physical activity; Voluntary exercise