title: Gene Expression of CYP1A1 and its Possible Clinical Application in Thyroid Cancer Cases.
abstract: BACKGROUND
  Thyroid cancer is the most common endocrine malignancy, and exact causes remain unknown. The role of CYP450 1A1 (CYP1A1) in cancer initiation and progression has been investigated. The aim of this work was to analyze, for the first time, CYP1A1 gene expression and its relationship with several clinicopathological factors in Mexican patients diagnosed with thyroid cancer.
  
  
  METHODS
  Realtime PCR analysis was conducted on 32 sets of thyroid tumors and benign pathologies. Expression levels were tested for correlations with clinical and pathological data. All statistical analysis were performed using GraphPad Prism version 3.0 software.
  
  
  RESULTS
  We found that female gender was associated with thyroid cancer risk (P<0.05). A positive relationship was identified between CYP1A1 mRNA levels and the presence of chronic disease, alcohol use, tumor size, metastasis and an advanced clinical stage (P<0.05).
  
  
  CONCLUSIONS
  The results suggest that CYP1A1 gene expression could be used as a marker for thyroid cancer.
authors: Service of Otolaryngology and Head and Neck Surgery, Hospital Central Militar, Secretaria de la Defensa Nacional, Mexico, Mexico Email : noemicr2001@yahoo.com.mx and floriano_esa@yahoo.com.
authors: Ja
authors: J
authors: GallegosVargas
authors: J
authors: J
authors: SanchezRoldan
authors: Md
authors: M
authors: RonquilloSanchez
authors: L
authors: L
authors: Carmona Aparicio
authors: E
authors: E
authors: FlorianoSanchez
authors: N
authors: N
authors: CardenasRodriguez
mesh_terms: D019363:Cytochrome P-450 CYP1A1 / Q000235:genetics*; D005260:Female; D015870:Gene Expression / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012333:RNA, Messenger / Q000235:genetics; D012306:Risk; D013961:Thyroid Gland / Q000473:pathology; D013964:Thyroid Neoplasms / Q000235:genetics* / Q000473:pathology*
chemical_list: D012333:RNA, Messenger; C569463:CYP1A1 protein, human; D019363:Cytochrome P-450 CYP1A1