title: Estrogen-related receptor β (ERRβ) - renaissance receptor or receptor renaissance?
abstract: Estrogen-related receptors (ERRs) are founding members of the orphan nuclear receptor (ONR) subgroup of the nuclear receptor superfamily. Twenty-seven years of study have yet to identify cognate ligands for the ERRs, though they have firmly placed ERRα and ERRγ at the intersection of cellular metabolism and oncogenesis. The pace of discovery for novel functions of ERRβ, however, has until recently been somewhat slower than that of its family members. ERRβ has also been largely ignored in summaries and perspectives of the ONR literature. Here, we provide an overview of established and emerging knowledge of ERRβ in mouse, man, and other species, highlighting unique aspects of ERRβ biology that set it apart from the other two estrogen-related receptors, with a focus on the impact of alternative splicing on the structure and function of this receptor.
authors: Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC (SDD, DMT, AF, RBR).
authors: Shailaja D
authors: SD
authors: Divekar
authors: Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC (SDD, DMT, AF, RBR).
authors: Deanna M
authors: DM
authors: Tiek
authors: Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC (SDD, DMT, AF, RBR).
authors: Aileen
authors: A
authors: Fernandez
authors: Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC (SDD, DMT, AF, RBR).
authors: Rebecca B
authors: RB
authors: Riggins
mesh_terms: D017398:Alternative Splicing; D000818:Animals; D006801:Humans; D009369:Neoplasms / Q000378:metabolism; D011960:Receptors, Estrogen / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism
chemical_list: D011960:Receptors, Estrogen; C107914:estrogen receptor-related receptor beta
keywords: ERRbeta; ERRβ; ESRRB; NR3B2; alternative splicing; orphan nuclear receptor