title: Pathophysiology of the Desmo-Adhesome.
abstract: Advances in our understanding of desmosomal diseases have provided a clear demonstration of the key role played by desmosomes in tissue and organ physiology, highlighting the importance of their dynamic and finely regulated structure. In this context, non-desmosomal regulatory molecules have acquired increasing relevance in the study of this organelle resulting in extending the desmosomal interactome, named the "desmo-adhesome." Spatiotemporal changes in the expression and regulation of the desmo-adhesome underlie a number of genetic, infectious, autoimmune, and malignant conditions. The aim of the present article was to examine the structural and functional relationship of the desmosome, by providing a comprehensive, yet focused overview of the constituents targeted in human disease. The inclusion of the novel regulatory network in the desmo-adhesome pathophysiology opens new avenues to a deeper understanding of desmosomal diseases, potentially unveiling pathogenic mechanisms waiting to be explored. J. Cell. Physiol. 232: 496-505, 2017. © 2016 Wiley Periodicals, Inc.
authors: Department of Neurosciences, Reproductive and Odontostomatological Sciences, University Federico II of Naples, Naples, Italy.|Melbourne Dental School, University of Melbourne, Carlton, Victoria, Australia.
authors: Antonio
authors: A
authors: Celentano
authors: Department of Neurosciences, Reproductive and Odontostomatological Sciences, University Federico II of Naples, Naples, Italy.
authors: Michele Davide
authors: MD
authors: Mignogna
authors: Melbourne Dental School, University of Melbourne, Carlton, Victoria, Australia.|Oral Health Cooperative Research Centre (CRC), University of Melbourne, Carlton, Victoria, Australia.
authors: Michael
authors: M
authors: McCullough
authors: Melbourne Dental School, University of Melbourne, Carlton, Victoria, Australia.|Oral Health Cooperative Research Centre (CRC), University of Melbourne, Carlton, Victoria, Australia.
authors: Nicola
authors: N
authors: Cirillo
mesh_terms: D000818:Animals; D002448:Cell Adhesion; D003896:Desmosomes / Q000378:metabolism* / Q000648:ultrastructure; D004194:Disease; D006801:Humans; D008954:Models, Biological; D015398:Signal Transduction