title: Vialinin A and thelephantin G, potent inhibitors of tumor necrosis factor-α production, inhibit sentrin/SUMO-specific protease 1 enzymatic activity.
abstract: Several p-terphenyl compounds have been isolated from the edible Chinese mushroom Thelephora vialis. Vialinin A, a p-terphenyl compound, strongly inhibits tumor necrosis factor-α production and release. Vialinin A inhibits the enzymatic activity of ubiquitin-specific peptidase 5, one of the target molecules in RBL-2H3 cells. Here we examined the inhibitory effect of p-terphenyl compounds, including vialinin A, against sentrin/SUMO-specific protease 1 (SENP1) enzymatic activity. The half maximal inhibitory concentration values of vialinin A and thelephantin G against full-length SENP1 were 1.64±0.23μM and 2.48±0.02μM, respectively. These findings suggest that p-terphenyl compounds are potent SENP1 inhibitors.
authors: Department of Nutritional Science and Food Safety, Faculty of Applied Bioscience, Tokyo University of Agriculture, 1-1-1 Sakuragaoka Setagaya-ku, Tokyo 156-8502, Japan; Organization of Advanced Science and Technology, Kobe University, Kobe, Hyogo 657-8501, Japan.
authors: Yasukiyo
authors: Y
authors: Yoshioka
authors: Department of Nutritional Science and Food Safety, Faculty of Applied Bioscience, Tokyo University of Agriculture, 1-1-1 Sakuragaoka Setagaya-ku, Tokyo 156-8502, Japan.
authors: Daisuke
authors: D
authors: Namiki
authors: Department of Nutritional Science and Food Safety, Faculty of Applied Bioscience, Tokyo University of Agriculture, 1-1-1 Sakuragaoka Setagaya-ku, Tokyo 156-8502, Japan.
authors: Mao
authors: M
authors: Makiuchi
authors: Department of Nutritional Science and Food Safety, Faculty of Applied Bioscience, Tokyo University of Agriculture, 1-1-1 Sakuragaoka Setagaya-ku, Tokyo 156-8502, Japan.
authors: Kouichi
authors: K
authors: Sugaya
authors: Department of Nutritional Science and Food Safety, Faculty of Applied Bioscience, Tokyo University of Agriculture, 1-1-1 Sakuragaoka Setagaya-ku, Tokyo 156-8502, Japan.
authors: Jun-Ichi
authors: J
authors: Onose
authors: Organization of Advanced Science and Technology, Kobe University, Kobe, Hyogo 657-8501, Japan; Department of Agrobioscience, Graduate School of Agricultural Science, Kobe University, Kobe, Hyogo 651-8501, Japan.
authors: Hitoshi
authors: H
authors: Ashida
authors: Department of Nutritional Science and Food Safety, Faculty of Applied Bioscience, Tokyo University of Agriculture, 1-1-1 Sakuragaoka Setagaya-ku, Tokyo 156-8502, Japan. Electronic address: abe@nodai.ac.jp.
authors: Naoki
authors: N
authors: Abe
mesh_terms: D000363:Agaricales / Q000737:chemistry / Q000378:metabolism; D000818:Animals; D002460:Cell Line; D006801:Humans; D007700:Kinetics; D011485:Protein Binding; D051381:Rats; D011994:Recombinant Proteins / Q000096:biosynthesis / Q000737:chemistry / Q000302:isolation & purification; D025842:SUMO-1 Protein / Q000037:antagonists & inhibitors / Q000378:metabolism*; D013730:Terphenyl Compounds / Q000737:chemistry / Q000378:metabolism*; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors / Q000378:metabolism*
chemical_list: D011994:Recombinant Proteins; D025842:SUMO-1 Protein; D013730:Terphenyl Compounds; D014409:Tumor Necrosis Factor-alpha; C000621457:thelephantin G; C508745:vialinin A
keywords: SENP1; SUMO; TNF-α; Vialinin A