title: Selective 5-aminolevulinic acid-induced protoporphyrin IX fluorescence in Gliomas.
abstract: Malignant gliomas are locally invasive tumors that offer a poor prognosis. Evidence shows that complete resection of the tumor at the time of surgery confers a significant improvement in overall survival. In recent years, 5- aminolevulinic acid (ALA)-induced fluorescence has been used by neurosurgeons to good effect in increasing the rate of complete resection. Despite the considerable interest in the use of 5-ALA in fluorescence-guided neurosurgery, the mechanisms behind the accumulation of Protoporphyrin IX (PpIX) in neoplastic tissue are unclear. In this review, we summarize the evidence in the literature on the mechanisms underlying the selective production of PpIX with a specific focus on gliomas.
authors: Department of Neurosurgery, John Radcliffe Hospital, Oxford University Hospitals NHS Trust, Headley Way, Oxford, OX3 9DU, UK. ruichong.ma@gmail.com.|Department of Neurosurgery, Addenbrookes Hospital, Cambridge University Hospitals NHS Foundation Trust, Hills Road, Cambridge, CB2 0QQ, UK. ruichong.ma@gmail.com.
authors: Ruichong
authors: R
authors: Ma
authors: Department of Neurosurgery, Addenbrookes Hospital, Cambridge University Hospitals NHS Foundation Trust, Hills Road, Cambridge, CB2 0QQ, UK.|Cambridge Centre for Brain Repair, University of Cambridge, Cambridge, UK.
authors: Colin
authors: C
authors: Watts
mesh_terms: D000622:Aminolevulinic Acid / Q000494:pharmacology*; D001932:Brain Neoplasms / Q000000981:diagnostic imaging / Q000378:metabolism / Q000601:surgery*; D005453:Fluorescence; D005910:Glioma / Q000000981:diagnostic imaging / Q000378:metabolism / Q000601:surgery*; D006801:Humans; D009474:Neurons / Q000187:drug effects / Q000378:metabolism; D019635:Neurosurgical Procedures / Q000379:methods*; D017319:Photosensitizing Agents / Q000494:pharmacology*; D011524:Protoporphyrins / Q000378:metabolism*
chemical_list: D017319:Photosensitizing Agents; D011524:Protoporphyrins; D000622:Aminolevulinic Acid; C028025:protoporphyrin IX
keywords: 5-ALA; Glioma; PpIX; fluorescence