title: Hapmnioides A-C, Rearranged Labdane-Type Diterpenoids from the Chinese Liverwort Haplomitrium mnioides.
abstract: Many exceptional labdane-type diterpenoids have been exclusively found in liverworts, which serve as taxonomic molecules or play important ecological roles in interactions among organisms. Three unprecedented labdane-type diterpenoids hapmnioides A (1), B (2), and C (3) formed through cascade rearrangement from the Chinese liverwort Haplomitrium mnioides are reported. Their structures were established by comprehensive spectroscopic analysis coupled with single-crystal X-ray diffraction, and their anti-inflammatory activities were also preliminarily tested.
authors: Department of Natural Products Chemistry, Key Lab of Chemical Biology (MOE), School of Pharmaceutical Sciences and ‡Department of Biochemistry and Molecular Biology, School of Medicine, Shandong University , No. 44 West Wenhua Road, Jinan 250012, P. R. China.
authors: Jinchuan
authors: J
authors: Zhou
authors: Department of Natural Products Chemistry, Key Lab of Chemical Biology (MOE), School of Pharmaceutical Sciences and ‡Department of Biochemistry and Molecular Biology, School of Medicine, Shandong University , No. 44 West Wenhua Road, Jinan 250012, P. R. China.
authors: Jiaozhen
authors: J
authors: Zhang
authors: Department of Natural Products Chemistry, Key Lab of Chemical Biology (MOE), School of Pharmaceutical Sciences and ‡Department of Biochemistry and Molecular Biology, School of Medicine, Shandong University , No. 44 West Wenhua Road, Jinan 250012, P. R. China.
authors: Ruijuan
authors: R
authors: Li
authors: Department of Natural Products Chemistry, Key Lab of Chemical Biology (MOE), School of Pharmaceutical Sciences and ‡Department of Biochemistry and Molecular Biology, School of Medicine, Shandong University , No. 44 West Wenhua Road, Jinan 250012, P. R. China.
authors: Jun
authors: J
authors: Liu
authors: Department of Natural Products Chemistry, Key Lab of Chemical Biology (MOE), School of Pharmaceutical Sciences and ‡Department of Biochemistry and Molecular Biology, School of Medicine, Shandong University , No. 44 West Wenhua Road, Jinan 250012, P. R. China.
authors: Peihong
authors: P
authors: Fan
authors: Department of Natural Products Chemistry, Key Lab of Chemical Biology (MOE), School of Pharmaceutical Sciences and ‡Department of Biochemistry and Molecular Biology, School of Medicine, Shandong University , No. 44 West Wenhua Road, Jinan 250012, P. R. China.
authors: Yi
authors: Y
authors: Li
authors: Department of Natural Products Chemistry, Key Lab of Chemical Biology (MOE), School of Pharmaceutical Sciences and ‡Department of Biochemistry and Molecular Biology, School of Medicine, Shandong University , No. 44 West Wenhua Road, Jinan 250012, P. R. China.
authors: Mei
authors: M
authors: Ji
authors: Department of Natural Products Chemistry, Key Lab of Chemical Biology (MOE), School of Pharmaceutical Sciences and ‡Department of Biochemistry and Molecular Biology, School of Medicine, Shandong University , No. 44 West Wenhua Road, Jinan 250012, P. R. China.
authors: Yiwen
authors: Y
authors: Dong
authors: Department of Natural Products Chemistry, Key Lab of Chemical Biology (MOE), School of Pharmaceutical Sciences and ‡Department of Biochemistry and Molecular Biology, School of Medicine, Shandong University , No. 44 West Wenhua Road, Jinan 250012, P. R. China.
authors: Huiqing
authors: H
authors: Yuan
authors: Department of Natural Products Chemistry, Key Lab of Chemical Biology (MOE), School of Pharmaceutical Sciences and ‡Department of Biochemistry and Molecular Biology, School of Medicine, Shandong University , No. 44 West Wenhua Road, Jinan 250012, P. R. China.
authors: Hongxiang
authors: H
authors: Lou
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D002460:Cell Line; D002681:China; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D035926:Hepatophyta / Q000737:chemistry*; D006801:Humans; D015850:Interleukin-6 / Q000378:metabolism; D051379:Mice; D008958:Models, Molecular; D008968:Molecular Conformation; D016328:NF-kappa B / Q000037:antagonists & inhibitors* / Q000378:metabolism; D015398:Signal Transduction / Q000187:drug effects*; D013237:Stereoisomerism; D000093242:Interleukin-6 Inhibitors
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D004224:Diterpenes; D015850:Interleukin-6; D016328:NF-kappa B; D000093242:Interleukin-6 Inhibitors