title: Role of micro-RNAs in drug resistance of multiple myeloma.
abstract: While novel therapeutic approaches have profoundly improved survival of multiple myeloma (MM) patients, drug resistance and treatment refractoriness still persists. This obstacle highly demands thorough investigation into the root and underlying molecular mechanisms to develop more effective strategies. The advent of micro-RNAs (miRNAs) in the study of cancer biology and pathogenesis in recent years has revolutionized therapy in this field and particularly opened new windows to further understanding of tumor drug resistance. However; in spite of the fact that miRNAs involvement in MM pathogenesis and progression has been substantially evidenced, miRNA investigation in MM drug resistance is still in its infancy. Our knowledge of the potential role of miRNAs in MM drug resistance comes from few recent reports confirming that some miRNAs including miR-137/197, miR-21 and miR-221/222 could negatively modulate drug sensitivity of MM cells. Further continuous researches are required to exploit miRNAs to elucidate the critical mechanisms controlling drug resistance in MM. In this review, we will highlight the most recent observations on the role of miRNAs in MM drug resistance. Moreover, approaches and insights into clinical application of miRNAs to overcome MM drug resistance will be discussed.
authors: Division of Molecular and Cellular Biology, Toronto General Research Institute, Toronto, Ontario, Canada.|Department of Laboratory Medicine & Pathobiology, University of Toronto, Toronto, Ontario, Canada.
authors: Jahangir
authors: J
authors: Abdi
authors: Department of Hematology, Shanghai Chang Zheng Hospital, Shanghai, China.
authors: Hou
authors: H
authors: Jian
authors: Division of Molecular and Cellular Biology, Toronto General Research Institute, Toronto, Ontario, Canada.|Department of Laboratory Medicine & Pathobiology, University of Toronto, Toronto, Ontario, Canada.|Department of Laboratory Hematology and Medical Oncology, University Health Network, Toronto, Ontario, Canada.
authors: Hong
authors: H
authors: Chang
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D001691:Biological Therapy; D019008:Drug Resistance, Neoplasm / Q000235:genetics; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D035683:MicroRNAs / Q000235:genetics*; D009101:Multiple Myeloma / Q000178:diet therapy*
chemical_list: D000970:Antineoplastic Agents; D035683:MicroRNAs
keywords: drug resistance; miRNA; multiple myeloma