title: Mutagenic induction of an ultra-fast water-chain proton wire.
abstract: Replacement of the hydroxyl group of a hydrophilic sidechain by an H atom in the proton wire of GFP induces formation of a water-chain proton wire. Surprisingly, this "non-native" water chain functions as a proton wire with response times within 10 ps of the wild type protein. This remarkable rate retention is understood as a natural consequence of the well-known Grotthuss mechanism of proton transfer in water.
authors: Department of Chemistry, Ben-Gurion University of the Negev, P.O. Box 653, Be'er Sheva 84105, Israel. ymiller@bgu.ac.il and Ilse Katz Institute for Nanoscale Science and Technology, Ben-Gurion University of the Negev, Beér-Sheva 84105, Israel.
authors: Vered
authors: V
authors: Wineman-Fisher
authors: Raymond and Beverly Sackler Faculty of Exact Sciences, School of Chemistry, Tel Aviv University, Tel Aviv 69978, Israel.
authors: Ron
authors: R
authors: Simkovich
authors: Raymond and Beverly Sackler Faculty of Exact Sciences, School of Chemistry, Tel Aviv University, Tel Aviv 69978, Israel.
authors: Dan
authors: D
authors: Huppert
authors: Department of Physics and Institute of Molecular Biology, University of Oregon, Eugene, USA.
authors: Kristina
authors: K
authors: Trujillo
authors: Department of Physics and Institute of Molecular Biology, University of Oregon, Eugene, USA.
authors: S James
authors: SJ
authors: Remington
authors: Department of Chemistry, Ben-Gurion University of the Negev, P.O. Box 653, Be'er Sheva 84105, Israel. ymiller@bgu.ac.il and Ilse Katz Institute for Nanoscale Science and Technology, Ben-Gurion University of the Negev, Beér-Sheva 84105, Israel.
authors: Yifat
authors: Y
authors: Miller