title: The use of brincidofovir for the treatment of mixed dsDNA viral infection.
abstract: Double-stranded DNA (dsDNA) viral infections constitute a major complication following solid organ and stem cell transplantation. Few therapeutic options are currently available for the treatment of such infections in highly immunocompromised hosts. Brincidofovir is an oral investigational drug with broad antiviral activity against dsDNA viruses in vitro, but clinical experience is limited. Here we report a young female who developed a mixed infection with adenovirus, cytomegalovirus, Epstein-Barr virus and BK polyomavirus after an allogeneic stem cell transplant, and was successfully treated with brincidofovir.
authors: Department of Medicine, Division of Infectious Diseases, University of Miami Miller School of Medicine, 1120 NW 14th Street, Miami, FL 33136, United States. Electronic address: jfc31@med.miami.edu.
authors: Jose F
authors: JF
authors: Camargo
authors: Department of Medicine, Division of Infectious Diseases, University of Miami Miller School of Medicine, 1120 NW 14th Street, Miami, FL 33136, United States.
authors: Michele I
authors: MI
authors: Morris
authors: Department of Medicine, Division of Infectious Diseases, University of Miami Miller School of Medicine, 1120 NW 14th Street, Miami, FL 33136, United States.
authors: Lilian M
authors: LM
authors: Abbo
authors: Department of Medicine, Division of Infectious Diseases, University of Miami Miller School of Medicine, 1120 NW 14th Street, Miami, FL 33136, United States.
authors: Jacques
authors: J
authors: Simkins
authors: Department of Pharmacy, Sylvester Cancer Center, University of Miami, 1475 NW 12th Ave, Miami, FL 33136, United States; Adult Stem Cell Transplant Program, Sylvester Cancer Center, University of Miami, 1475 NW 12th Ave, Miami, FL 33136, United States.
authors: Seyyedeh
authors: S
authors: Saneeymehri
authors: Adult Stem Cell Transplant Program, Sylvester Cancer Center, University of Miami, 1475 NW 12th Ave, Miami, FL 33136, United States.
authors: Maritza C
authors: MC
authors: Alencar
authors: Adult Stem Cell Transplant Program, Sylvester Cancer Center, University of Miami, 1475 NW 12th Ave, Miami, FL 33136, United States; Department of Medicine, Division of Hematology, University of Miami Miller School of Medicine, 1120 NW 14th Street, Miami, FL 33136, United States.
authors: Lazaros J
authors: LJ
authors: Lekakis
authors: Adult Stem Cell Transplant Program, Sylvester Cancer Center, University of Miami, 1475 NW 12th Ave, Miami, FL 33136, United States; Department of Medicine, Division of Hematology, University of Miami Miller School of Medicine, 1120 NW 14th Street, Miami, FL 33136, United States.
authors: Krishna V
authors: KV
authors: Komanduri
mesh_terms: D000328:Adult; D000998:Antiviral Agents / Q000627:therapeutic use*; D001739:BK Virus; D060085:Coinfection / Q000188:drug therapy / Q000821:virology; D003587:Cytomegalovirus; D003596:Cytosine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D004266:DNA Virus Infections / Q000188:drug therapy / Q000821:virology; D017809:Fatal Outcome; D005260:Female; D004854:Herpesvirus 4, Human; D006801:Humans; D016867:Immunocompromised Host; D063065:Organophosphonates / Q000627:therapeutic use*; D033581:Stem Cell Transplantation; D019562:Viral Load; D055815:Young Adult
chemical_list: D000998:Antiviral Agents; D063065:Organophosphonates; C525733:brincidofovir; D003596:Cytosine
keywords: Adenovirus; BK virus; Brincidofovir; CMX001; Cytomegalovirus; Epstein–Barr virus