title: Prolonged drug-induced myoclonus: is it related to palonosetron?
abstract: We report a case of drug-induced myoclonus possibly related to palonosetron, a second-generation 5-hydroxytryptamine-3 receptor antagonist which was administered as a prophylaxis for postoperative nausea and vomiting in a 28-year-old female. The recurrent episodes of myoclonus jerk involving the head, neck and shoulder persisted for a period of 4 days. The patient also exhibited an episode of severe bradycardia leading to hypotension 7 h after surgery. To our knowledge, this is the first report presenting these adverse events potentially associated with the use of palonosetron.
authors: Department of Anaesthesiology, Faculty of Medicine, University of Malaya, 50603, Kuala Lumpur, Malaysia. sh_chaw@yahoo.com.
authors: Sook Hui
authors: 0000-0003-3886-6435
authors: SH
authors: Chaw
authors: Department of Anaesthesiology, Faculty of Medicine, University of Malaya, 50603, Kuala Lumpur, Malaysia.
authors: Lucy
authors: L
authors: Chan
authors: Department of Anaesthesiology, Faculty of Medicine, University of Malaya, 50603, Kuala Lumpur, Malaysia.
authors: Pui Kuan
authors: PK
authors: Lee
authors: Darul Ehsan Medical Centre Specialist Hospital, 40000, Shah Alam, Selangor, Malaysia.
authors: Jaseemuddeen A
authors: JA
authors: Bakar
authors: Darul Ehsan Medical Centre Specialist Hospital, 40000, Shah Alam, Selangor, Malaysia.
authors: Raveenthiran
authors: R
authors: Rasiah
authors: Department of Anaesthesiology, Faculty of Medicine, University of Malaya, 50603, Kuala Lumpur, Malaysia.
authors: Li Lian
authors: LL
authors: Foo
mesh_terms: D000328:Adult; D000932:Antiemetics / Q000009:adverse effects* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007546:Isoquinolines / Q000009:adverse effects* / Q000627:therapeutic use; D009207:Myoclonus / Q000139:chemically induced*; D000077924:Palonosetron; D020250:Postoperative Nausea and Vomiting / Q000517:prevention & control; D011812:Quinuclidines / Q000009:adverse effects* / Q000627:therapeutic use
chemical_list: D000932:Antiemetics; D007546:Isoquinolines; D011812:Quinuclidines; D000077924:Palonosetron
keywords: 5- hydroxytryptamine-3 receptor antagonist; Drug-induced myoclonus; Palonosetron