title: Using Metabolomic Profiles as Biomarkers for Insulin Resistance in Childhood Obesity: A Systematic Review.
abstract: A growing body of evidence has shown the intimate relationship between metabolomic profiles and insulin resistance (IR) in obese adults, while little is known about childhood obesity. In this review, we searched available papers addressing metabolomic profiles and IR in obese children from inception to February 2016 on MEDLINE, Web of Science, the Cochrane Library, ClinicalTrials.gov, and EMASE. HOMA-IR was applied as surrogate markers of IR and related metabolic disorders at both baseline and follow-up. To minimize selection bias, two investigators independently completed this work. After critical selection, 10 studies (including 2,673 participants) were eligible and evaluated by using QUADOMICS for quality assessment. Six of the 10 studies were classified as "high quality." Then we generated all the metabolites identified in each study and found amino acid metabolism and lipid metabolism were the main affected metabolic pathways in obese children. Among identified metabolites, branched-chain amino acids (BCAAs), aromatic amino acids (AAAs), and acylcarnitines were reported to be associated with IR as biomarkers most frequently. Additionally, BCAAs and tyrosine seemed to be relevant to future metabolic risk in the long-term follow-up cohorts, emphasizing the importance of early diagnosis and prevention strategy. Because of limited scale and design heterogeneity of existing studies, future studies might focus on validating above findings in more large-scale and longitudinal studies with elaborate design.
authors: Department of Endocrinology and Metabolism, The First Hospital of Jilin University, Changchun 130021, China.
authors: Xue
authors: 0000-0001-8985-1861
authors: X
authors: Zhao
authors: Department of Endocrinology and Metabolism, The First Hospital of Jilin University, Changchun 130021, China.
authors: Xiaokun
authors: 0000-0002-9463-5175
authors: X
authors: Gang
authors: Department of Endocrinology and Metabolism, The First Hospital of Jilin University, Changchun 130021, China.
authors: Yujia
authors: 0000-0002-6436-6998
authors: Y
authors: Liu
authors: Department of Endocrinology and Metabolism, The First Hospital of Jilin University, Changchun 130021, China.
authors: Chenglin
authors: C
authors: Sun
authors: Hospital of Orthopedics, The Second Hospital of Jilin University, Changchun 130021, China.
authors: Qing
authors: 0000-0002-1404-1562
authors: Q
authors: Han
authors: Department of Endocrinology and Metabolism, The First Hospital of Jilin University, Changchun 130021, China.
authors: Guixia
authors: 0000-0001-8107-616X
authors: G
authors: Wang
mesh_terms: D024322:Amino Acids, Aromatic / Q000378:metabolism; D000597:Amino Acids, Branched-Chain / Q000378:metabolism; D015415:Biomarkers / Q000378:metabolism; D002331:Carnitine / Q000031:analogs & derivatives / Q000378:metabolism; D002648:Child; D006801:Humans; D007333:Insulin Resistance; D055432:Metabolomics; D063766:Pediatric Obesity / Q000378:metabolism*
chemical_list: D024322:Amino Acids, Aromatic; D000597:Amino Acids, Branched-Chain; D015415:Biomarkers; C116917:acylcarnitine; D002331:Carnitine