title: Health-Related Quality of Life (HRQoL) in Idiopathic Inflammatory Myopathy: A Systematic Review.
abstract: Health-related quality of life (HRQoL) is a research priority in chronic diseases. We undertook a systematic review (registration #CRD42015024939) to identify, appraise and synthesize the evidence relating to HRQoL in idiopathic inflammatory myopathies (IIM). A comprehensive search was conducted in August 2015 using CINAHL, EMBase and Pubmed to identify studies reporting original data on HRQoL in IIM using generic HRQoL instruments. Characteristics of samples and results from selected studies were extracted and appraised using a standardized approach. Qualitative synthesis of the results was performed. Ten studies including a total of 654 IIM subjects were included in this systematic review. HRQoL was significantly impaired in all subsets of IIM compared with the general population. Disease activity, disease damage and chronic disease course were associated with poorer HRQoL. Insufficient or conflicting results were found in associations between clinical features, treatment, disease duration and mood or illness perception, and HRQoL in IIM. This study suggests that HRQoL is impaired in IIM. However, due to the paucity and heterogeneity of the evidence to date, robust estimates are lacking and significant knowledge gaps persist. There is a need for studies that systematically investigate the correlates and trajectory of HRQoL in IIM.
authors: Department of Medicine, Division of Rheumatology, McGill University, Montreal, Canada.
authors: Valérie
authors: V
authors: Leclair
authors: Department of Occupational Therapy, Karolinska University Hospital, Stockholm, Sweden.|Department of Learning, Division of Informatics and Medical Education, Karolinska Institutet, Stockholm, Sweden.
authors: Malin
authors: M
authors: Regardt
authors: Department of Medicine, Division of Rheumatology, McGill University, Montreal, Canada.
authors: Sophie
authors: S
authors: Wojcik
authors: Department of Medicine, Division of Rheumatology, McGill University, Montreal, Canada.|Department of Medicine, Division of Rheumatology, Jewish General Hospital, Montreal, Canada.|Lady Davis Institute for Medical Research, Division of Clinical Epidemiology, Jewish General Hospital, Montreal, Canada.
authors: Marie
authors: M
authors: Hudson
mesh_terms: D006304:Health Status; D006801:Humans; D009220:Myositis / Q000628:therapy; D011788:Quality of Life