title: Water soluble extracts from Actinidia arguta, PG102, attenuates house dust mite-induced murine atopic dermatitis by inhibiting the mTOR pathway with Treg generation.
abstract: BACKGROUND
  Actinidia arguta is widespread in northeastern Asia, being found in Siberia, Korea, Japan, and northern China. These fruits have been documented to regulate the uncontrolled heat of body resulting in various allergic diseases in the Korean traditional medicine. PG102, a water-soluble extract from an edible fruit, A. arguta, has been previously shown to control various factors involved in allergic pathogenesis.
  
  
  OBJECTIVE
  In this study, we investigated whether PG102 prevents chronic allergic reactions via the generation of Tregs, which play a preventive role in the pathogenesis of allergic disease.
  
  
  RESULTS
  In dust mite extract-induced chronic atopic dermatitis, orally administered PG102 inhibited symptoms of dermatitis, including ear swelling and erythema, and decreased lymphocyte infiltration into the inflamed region. Moreover, PG102 reduced inflammatory T cell responses and increased the expression levels of Foxp3 and other Treg-related genes. PG102 treatment enhanced the induction of CD4+Foxp3+ Tregs from naive CD4+CD62L+ T cells, probably via the inhibition of mTOR activation and the phosphorylation of STAT5 rather than using the TGF-β signaling pathway.
  
  
  CONCLUSIONS
  PG102 may have potential as an orally active immunosuppressor for preventing chronic inflammatory diseases.
authors: Institutes of Entrepreneurial BioConvergence, Seoul National University, Seoul 151-742, Republic of Korea.
authors: Min-Jung
authors: MJ
authors: Bae
authors: Laboratory of Virology, School of Biological Sciences, Seoul National University, Seoul 151-742, Republic of Korea.
authors: Seonung
authors: S
authors: Lim
authors: ViroMed Co., Ltd., Republic of Korea.
authors: Doo Suk
authors: DS
authors: Lee
authors: Laboratory of Virology, School of Biological Sciences, Seoul National University, Seoul 151-742, Republic of Korea.
authors: Kyoung Ryang
authors: KR
authors: Ko
authors: Laboratory of Virology, School of Biological Sciences, Seoul National University, Seoul 151-742, Republic of Korea.
authors: Wonwoo
authors: W
authors: Lee
authors: Institutes of Entrepreneurial BioConvergence, Seoul National University, Seoul 151-742, Republic of Korea; Laboratory of Virology, School of Biological Sciences, Seoul National University, Seoul 151-742, Republic of Korea; ViroMed Co., Ltd., Republic of Korea. Electronic address: sunyoung@snu.ac.kr.
authors: Sunyoung
authors: S
authors: Kim
mesh_terms: D029042:Actinidia / Q000737:chemistry*; D000818:Animals; D003876:Dermatitis, Atopic / Q000188:drug therapy / Q000276:immunology; D051379:Mice; D010936:Plant Extracts / Q000494:pharmacology*; D039981:Pyroglyphidae / Q000276:immunology*; D015398:Signal Transduction / Q000187:drug effects / Q000276:immunology; D050378:T-Lymphocytes, Regulatory / Q000187:drug effects / Q000276:immunology; D058570:TOR Serine-Threonine Kinases / Q000276:immunology
chemical_list: D010936:Plant Extracts; D058570:TOR Serine-Threonine Kinases
keywords: Actinidia arguta; Atopic dermatittis; Foxp3; MTOR; PG102; STAT5