title: Receptor-ligand interactions: Advanced biomedical applications.
abstract: Receptor-ligand interactions (RLIs) are at the base of all biological events occurring in living cells. The understanding of interactions between complementary macromolecules in biological systems represents a high-priority research area in bionanotechnology to design the artificial systems mimicking natural processes. This review summarizes and analyzes RLIs in some cutting-edge biomedical fields, in particular, for the preparation of novel stationary phases to separate complex biological mixtures in medical diagnostics, for the design of ultrasensitive biosensors for identification of biomarkers of various diseases at early stages, as well as in the development of innovative biomaterials and approaches for regenerative medicine. All these biotechnological fields are closely related, because their success depends on a proper choice, combination and spatial disposition of the single components of ligand-receptor pairs on the surface of appropriately designed support.
authors: Institute of Chemistry, St. Petersburg State University, 198504 St. Petersburg, Russia. Electronic address: ivan.guryanov1@gmail.com.
authors: Ivan
authors: I
authors: Guryanov
authors: Department of Clinical and Experimental Medicine, University of Perugia, 06122 Perugia, Italy. Electronic address: fiorucci@unipg.it.
authors: Stefano
authors: S
authors: Fiorucci
authors: Institute of Chemistry, St. Petersburg State University, 198504 St. Petersburg, Russia. Electronic address: tennikova@mail.ru.
authors: Tatiana
authors: T
authors: Tennikova
mesh_terms: D000818:Animals; D032701:Biomimetics / Q000379:methods*; D006801:Humans; D008024:Ligands; D036103:Nanotechnology / Q000379:methods*; D011956:Receptors, Cell Surface
chemical_list: D008024:Ligands; D011956:Receptors, Cell Surface
keywords: Affinity chromatography; Biosensor; Ligand; Receptor; Regenerative medicine; Tissue engineering