title: Primary thymic mediastinal seminoma with florid granulomatous reaction.
abstract: Primary mediastinal seminomas are rare tumors. Morphologically, they can be associated with secondary changes in the form of thymic remnants, cystic change, epithelioid granulomas, abundant fibrosis, and syncytiotrophoblast like cells. Ours was an interesting case where a 17-year-old adolescent male presented with anterior mediastinal mass. Fine needle aspiration and trucut biopsy of the mass favored tuberculosis; however, he did not respond to antituberculosis treatment regime. He was subjected to video-assisted thoracoscopic surgery and the histopathological examination along with supportive immunohistochemistry of the mass revealed scattered seminoma cells which were being masked by extensive granulomatous reaction. The aim of this article is to report a case of primary mediastinal thymic seminoma in a young male associated with extensive granulomatous reaction masking the neoplastic population of cells leading to erroneous diagnosis on small biopsy.
authors: Department of Pathology and Laboratory Science, Armed Forces Medical College, Command Hospital, Pune, Maharashtra, India.
authors: Devika
authors: D
authors: Gupta
authors: Department of Pathology and Laboratory Science, Armed Forces Medical College, Command Hospital, Pune, Maharashtra, India.
authors: Ashutosh
authors: A
authors: Rath
authors: Department of Pathology and Laboratory Science, Command Hospital, Pune, Maharashtra, India.
authors: Khushi Ram
authors: KR
authors: Rathi
authors: Department of Radiodiagnosis and Imaging, Armed Forces Medical College, Command Hospital, Pune, Maharashtra, India.
authors: Giriraj
authors: G
authors: Singh
mesh_terms: D000293:Adolescent; D014408:Biomarkers, Tumor / Q000032:analysis; D001706:Biopsy; D044963:Biopsy, Fine-Needle; D006651:Histocytochemistry; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008479:Mediastinal Neoplasms / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology*; D008853:Microscopy; D019009:Proto-Oncogene Proteins c-kit / Q000032:analysis; D013902:Radiography, Thoracic; D018239:Seminoma / Q000175:diagnosis* / Q000473:pathology*; D013953:Thymus Neoplasms / Q000175:diagnosis* / Q000473:pathology*; D014057:Tomography, X-Ray Computed
chemical_list: D014408:Biomarkers, Tumor; D019009:Proto-Oncogene Proteins c-kit