title: "Cumulative Stress": The Effects of Maternal and Neonatal Oxidative Stress and Oxidative Stress-Inducible Genes on Programming of Atopy.
abstract: Although extensive epidemiological and laboratory studies have been performed to identify the environmental and immunological causes of atopy, genetic predisposition seems to be the biggest risk factor for allergic diseases. The onset of atopic diseases may be the result of heritable changes of gene expression, without any alteration in DNA sequences occurring in response to early environmental stimuli. Findings suggest that the establishment of a peculiar epigenetic pattern may also be generated by oxidative stress (OS) and perpetuated by the activation of OS-related genes. Analyzing the role of maternal and neonatal oxidative stress and oxidative stress-inducible genes, the purpose of this review was to summarize what is known about the relationship between maternal and neonatal OS-related genes and the development of atopic diseases.
authors: Unit of Pediatric Genetics and Immunology, Department of Pediatrics, University of Messina, 98125 Messina, Italy.
authors: Sara
authors: 0000-0002-7664-3083
authors: S
authors: Manti
authors: Neonatal and Pediatric Intensive Care Unit, Department of Pediatrics, University of Messina, 98125 Messina, Italy.
authors: Lucia
authors: 0000-0003-0720-9387
authors: L
authors: Marseglia
authors: Neonatal and Pediatric Intensive Care Unit, Department of Pediatrics, University of Messina, 98125 Messina, Italy.
authors: Gabriella
authors: G
authors: D'Angelo
authors: Unit of Pediatric Genetics and Immunology, Department of Pediatrics, University of Messina, 98125 Messina, Italy.
authors: Caterina
authors: C
authors: Cuppari
authors: Neonatal and Pediatric Intensive Care Unit, Department of Pediatrics, University of Messina, 98125 Messina, Italy.
authors: Erika
authors: E
authors: Cusumano
authors: Unit of Pediatric Genetics and Immunology, Department of Pediatrics, University of Messina, 98125 Messina, Italy.
authors: Teresa
authors: T
authors: Arrigo
authors: Neonatal and Pediatric Intensive Care Unit, Department of Pediatrics, University of Messina, 98125 Messina, Italy.
authors: Eloisa
authors: E
authors: Gitto
authors: Unit of Pediatric Genetics and Immunology, Department of Pediatrics, University of Messina, 98125 Messina, Italy.
authors: Carmelo
authors: C
authors: Salpietro
mesh_terms: D044127:Epigenesis, Genetic; D005786:Gene Expression Regulation; D020022:Genetic Predisposition to Disease; D040941:Heredity; D006801:Humans; D006967:Hypersensitivity / Q000235:genetics* / Q000276:immunology / Q000378:metabolism; D007231:Infant, Newborn; D008297:Male; D018384:Oxidative Stress / Q000235:genetics*; D010641:Phenotype; D012307:Risk Factors