title: Evidence of Echocardiography Validity in Model Experiments on Small Animals.
abstract: Dynamic echocardiographic monitoring in rats subjected to forced alcoholization showed the formation of disorders in intracardiac hemodynamics characteristic of ethanol cardiomyopathy formed by the end of 24-week continuous ethanol consumption. The results of echocardiographic monitoring were confirmed by histological and morphometric studies demonstrating fatty infiltration of the myocardium pathognomonic for this condition and bifocal dilatation of cardiac ventricles. These results persuasively demonstrate that echocardiographic studies on small animals are valid and can be used for search for cardiotropic drugs and studies of the mechanisms of their activities.
authors: V. V. Zakusov Research Institute of Pharmacology, Moscow, Russia. SAK-538@yandex.ru.
authors: S A
authors: SA
authors: Kryzhanovskii
authors: V. V. Zakusov Research Institute of Pharmacology, Moscow, Russia.
authors: L G
authors: LG
authors: Kolik
authors: V. V. Zakusov Research Institute of Pharmacology, Moscow, Russia.
authors: I B
authors: IB
authors: Tsorin
authors: V. V. Zakusov Research Institute of Pharmacology, Moscow, Russia.
authors: E O
authors: EO
authors: Ionova
authors: V. V. Zakusov Research Institute of Pharmacology, Moscow, Russia.
authors: V N
authors: VN
authors: Stolyaruk
authors: V. V. Zakusov Research Institute of Pharmacology, Moscow, Russia.
authors: A V
authors: AV
authors: Sorokina
authors: V. V. Zakusov Research Institute of Pharmacology, Moscow, Russia.
authors: M B
authors: MB
authors: Vititnova
authors: V. V. Zakusov Research Institute of Pharmacology, Moscow, Russia.
authors: I A
authors: IA
authors: Miroshkina
mesh_terms: D000818:Animals; D009202:Cardiomyopathies / Q000139:chemically induced / Q000473:pathology*; D004452:Echocardiography / Q000379:methods*; D000431:Ethanol / Q000009:adverse effects; D006439:Hemodynamics; D008297:Male; D009206:Myocardium / Q000473:pathology*; D051381:Rats
chemical_list: D000431:Ethanol
keywords: dilated alcoholic cardiomyopathy; echocardiography; myocardial pathomorphology; rats; validity