title: Brain networks of temporal preparation: A multiple regression analysis of neuropsychological data.
abstract: There are only a few studies on the brain networks involved in the ability to prepare in time, and most of them followed a correlational rather than a neuropsychological approach. The present neuropsychological study performed multiple regression analysis to address the relationship between both grey and white matter (measured by magnetic resonance imaging in patients with brain lesion) and different effects in temporal preparation (Temporal orienting, Foreperiod and Sequential effects). Two versions of a temporal preparation task were administered to a group of 23 patients with acquired brain injury. In one task, the cue presented (a red versus green square) to inform participants about the time of appearance (early versus late) of a target stimulus was blocked, while in the other task the cue was manipulated on a trial-by-trial basis. The duration of the cue-target time intervals (400 versus 1400ms) was always manipulated within blocks in both tasks. Regression analysis were conducted between either the grey matter lesion size or the white matter tracts disconnection and the three temporal preparation effects separately. The main finding was that each temporal preparation effect was predicted by a different network of structures, depending on cue expectancy. Specifically, the Temporal orienting effect was related to both prefrontal and temporal brain areas. The Foreperiod effect was related to right and left prefrontal structures. Sequential effects were predicted by both parietal cortex and left subcortical structures. These findings show a clear dissociation of brain circuits involved in the different ways to prepare in time, showing for the first time the involvement of temporal areas in the Temporal orienting effect, as well as the parietal cortex in the Sequential effects.
authors: Department of Neuropsychology, San Rafael University Hospital, Granada - 18001, Spain; Mind, Brain and Behaviour Research Center (CIMCYC), University of Granada - 18011, Spain. Electronic address: mtrivino@ugr.es.
authors: Mónica
authors: M
authors: Triviño
authors: Mind, Brain and Behaviour Research Center (CIMCYC), University of Granada - 18011, Spain; Department of Experimental Psychology, University of Granada - 18011, Spain.
authors: Ángel
authors: Á
authors: Correa
authors: Mind, Brain and Behaviour Research Center (CIMCYC), University of Granada - 18011, Spain; Department of Experimental Psychology, University of Granada - 18011, Spain.
authors: Juan
authors: J
authors: Lupiáñez
authors: Mind, Brain and Behaviour Research Center (CIMCYC), University of Granada - 18011, Spain; Department of Experimental Psychology, University of Granada - 18011, Spain.
authors: María Jesús
authors: MJ
authors: Funes
authors: Mind, Brain and Behaviour Research Center (CIMCYC), University of Granada - 18011, Spain; Department of Experimental Psychology, University of Granada - 18011, Spain.
authors: Andrés
authors: A
authors: Catena
authors: Cognition and Cognitive Neuroscience Research Centre, Department of Psychology, Bournemouth University - BH12 5BB, UK.
authors: Xun
authors: X
authors: He
authors: Department of Experimental Psychology, University of Oxford - OX1 3UD, UK.
authors: Glyn W
authors: GW
authors: Humphreys
mesh_terms: D000368:Aged; D002540:Cerebral Cortex / Q000000981:diagnostic imaging / Q000473:pathology / Q000503:physiopathology; D005260:Female; D066128:Gray Matter / Q000000981:diagnostic imaging / Q000473:pathology / Q000503:physiopathology; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D009415:Nerve Net / Q000000981:diagnostic imaging / Q000473:pathology / Q000503:physiopathology; D009949:Orientation / Q000502:physiology*; D011597:Psychomotor Performance / Q000502:physiology*; D012044:Regression Analysis; D013997:Time Factors; D013998:Time Perception / Q000502:physiology*; D066127:White Matter / Q000000981:diagnostic imaging / Q000473:pathology / Q000503:physiopathology
keywords: Foreperiod; Regression analysis; Temporal lobe; Temporal orienting; Temporal preparation