title: No difference in health-related quality of life, after a food challenge with cashew nut in children participating in a clinical trial.
abstract: Previous studies showed that health-related quality of life (HRQL) significantly improved after the food challenge, with greater improvements in HRQL after a negative outcome than after a positive outcome. It is currently unknown whether this also occurs in patients undergoing DBPCFCs with cashew nut in the context of a clinical trial.
  
  
  
  Quality of life was studied in children enrolled in a cashew nut study using Food Allergy Quality of Life Questionnaires (FAQLQs). Children, teenagers and parents of the children completed the questionnaires before the challenge test and 6 months after the DBPCFC with cashew nut. The difference in the change in HRQL between the children with a positive and negative DBPCFC outcome was studied by Mann-Whitney U-test.
  
  
  
  In total, 112 children (67 boys, median age of 9 years) were included. The children, teenagers and parents of the children completed 143 sets of questionnaires in total. There were no significant differences in baseline total and domain scores compared to the follow-up scores in the FAQLQ-CF, FAQLQ-TF and FAQLQ-PF. In children, the delta FAIM score in the negative DBPCFC tested group was significantly better than the delta FAIM score in the positive challenged group (p = 0.026). There were no significant differences in the changes in the scores of the FAQLQ-CF and FAQLQ-PF in the children with a positive challenge outcome, compared to the children with a negative challenge result. However, there was a significant difference in the change in score between the latter groups in the domain 'accidental exposure' of the FAQLQ-TF (p = 0.049).
  
  
  
  This study showed no difference in the change in HRQL scores after a DBPCFC with cashew nut in children participating in a clinical trial. The utility of HRQL as an outcome for clinical trials in food allergy may be limited if participant baseline HRQL is relatively unimpaired.
authors: Department Of Internal Medicine, Allergology, Erasmus MC, Rotterdam, The Netherlands.
authors: J P M
authors: JP
authors: van der Valk
authors: Department Of Internal Medicine, Allergology, Erasmus MC, Rotterdam, The Netherlands.
authors: R
authors: R
authors: Gerth van Wijk
authors: Department of General Practice, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands.
authors: B M J
authors: BM
authors: Flokstra-de Blok
authors: Department of General Practice, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands.
authors: J L
authors: JL
authors: van der Velde
authors: Department of Pediatric Allergology, Diaconessenhuis Voorburg, RdGG, Delft, The Netherlands.
authors: H
authors: H
authors: de Groot
authors: Wageningen UR Food & Biobased Research, Wageningen, The Netherlands.
authors: H J
authors: HJ
authors: Wichers
authors: Department of Pediatric Pulmonology and Pediatric Allergology, GRIAC Research Institute, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands.
authors: A E J
authors: AE
authors: Dubois
authors: Department Of Internal Medicine, Allergology, Erasmus MC, Rotterdam, The Netherlands.
authors: N W
authors: NW
authors: de Jong
mesh_terms: D000293:Adolescent; D000485:Allergens / Q000276:immunology*; D031021:Anacardium / Q000276:immunology; D002648:Child; D002675:Child, Preschool; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007114:Immunization; D008297:Male; D021184:Nut Hypersensitivity / Q000175:diagnosis*; D010290:Parents; D011788:Quality of Life; D011795:Surveys and Questionnaires
chemical_list: D000485:Allergens
keywords: Food Allergy Quality of Life Questionnaire; anaphylaxis; cashew nut allergy; double-blind placebo-controlled food challenge