title: Nonsteroidal anti-inflammatory drug administration in children with history of wheeze.
abstract: OBJECTIVE
  A child in my clinic who recently sprained his ankle is experiencing pain and having trouble bearing weight on the affected leg. His mother has been giving him acetaminophen, as she was told never to use nonsteroidal anti-inflammatory drugs (NSAIDs) because of his pharmacologically controlled asthma. Is asthma in children a contraindication to giving NSAIDs? Is NSAID-exacerbated respiratory disease (NERD) a real entity?
  
  
  CONCLUSIONS
  Nonsteroidal anti-inflammatory drugs are effective analgesic and antipyretic medications. While described in adults with some predisposing conditions, NERD has not been clearly described in a large number of children. Nonsteroidal anti-inflammatory drugs can be recommended to children with known wheeze who do not have a history of NERD reaction.
authors: Kendra
authors: K
authors: Sih
authors: Ran D
authors: RD
authors: Goldman
mesh_terms: D000328:Adult; D000894:Anti-Inflammatory Agents, Non-Steroidal; D001249:Asthma; D002648:Child; D000075202:Contraindications; D004342:Drug Hypersensitivity / Q000453:epidemiology*; D006801:Humans; D016032:Randomized Controlled Trials as Topic; D012135:Respiratory Sounds
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal