title: Catalytic enantio- and diastereoselective Mannich reaction of α-substituted isocyanoacetates and ketimines.
abstract: The highly diastereo- and enantioselective Mannich addition/cyclisation reaction of α-substituted isocyanoacetate ester pronucleophiles and (hetero)aryl and alkyl methyl ketone-derived ketimines using a silver acetate and a cinchona-derived amino phosphine binary catalyst system is reported.
authors: Chemistry Research Laboratory, Department of Chemistry, University of Oxford, Mansfield Road, Oxford, OX1 3TA, UK. darren.dixon@chem.ox.ac.uk.
authors: Raquel
authors: R
authors: de la Campa
authors: Chemistry Research Laboratory, Department of Chemistry, University of Oxford, Mansfield Road, Oxford, OX1 3TA, UK. darren.dixon@chem.ox.ac.uk.
authors: Adam D
authors: AD
authors: Gammack Yamagata
authors: Chemistry Research Laboratory, Department of Chemistry, University of Oxford, Mansfield Road, Oxford, OX1 3TA, UK. darren.dixon@chem.ox.ac.uk.
authors: Irene
authors: I
authors: Ortín
authors: Chemistry Research Laboratory, Department of Chemistry, University of Oxford, Mansfield Road, Oxford, OX1 3TA, UK. darren.dixon@chem.ox.ac.uk.
authors: Allegra
authors: A
authors: Franchino
authors: Chemistry Research Laboratory, Department of Chemistry, University of Oxford, Mansfield Road, Oxford, OX1 3TA, UK. darren.dixon@chem.ox.ac.uk.
authors: Amber L
authors: AL
authors: Thompson
authors: Chemistry Research Laboratory, Department of Chemistry, University of Oxford, Mansfield Road, Oxford, OX1 3TA, UK. darren.dixon@chem.ox.ac.uk.
authors: Barbara
authors: B
authors: Odell
authors: Chemistry Research Laboratory, Department of Chemistry, University of Oxford, Mansfield Road, Oxford, OX1 3TA, UK. darren.dixon@chem.ox.ac.uk.
authors: Darren J
authors: DJ
authors: Dixon