title: Non-linear dual-phase-lag model for analyzing heat transfer phenomena in living tissues during thermal ablation.
abstract: In this article, a non-linear dual-phase-lag (DPL) bio-heat transfer model based on temperature dependent metabolic heat generation rate is derived to analyze the heat transfer phenomena in living tissues during thermal ablation treatment. The numerical solution of the present non-linear problem has been done by finite element Runge-Kutta (4,5) method which combines the essence of Runge-Kutta (4,5) method together with finite difference scheme. Our study demonstrates that at the thermal ablation position temperature predicted by non-linear and linear DPL models show significant differences. A comparison has been made among non-linear DPL, thermal wave and Pennes model and it has been found that non-linear DPL and thermal wave bio-heat model show almost same nature whereas non-linear Pennes model shows significantly different temperature profile at the initial stage of thermal ablation treatment. The effect of Fourier number and Vernotte number (relaxation Fourier number) on temperature profile in presence and absence of externally applied heat source has been studied in detail and it has been observed that the presence of externally applied heat source term highly affects the efficiency of thermal treatment method.
authors: Dept. of Mathematical Sciences, IIT (BHU), Varanasi-221005, India. Electronic address: pkumar.rs.apm12@itbhu.ac.in.
authors: P
authors: P
authors: Kumar
authors: DST-CIMS, Faculty of Science, BHU, Varanasi-221005, India. Electronic address: dineshaukumar@gmail.com.
authors: Dinesh
authors: D
authors: Kumar
authors: Dept. of Mathematical Sciences, IIT (BHU), Varanasi-221005, India; DST-CIMS, Faculty of Science, BHU, Varanasi-221005, India. Electronic address: knrai.apm@itbhu.ac.in.
authors: K N
authors: KN
authors: Rai
mesh_terms: D001833:Body Temperature Regulation; D003198:Computer Simulation; D020342:Finite Element Analysis; D006358:Hot Temperature; D006801:Humans; D006979:Hyperthermia, Induced / Q000379:methods; D008954:Models, Biological; D009369:Neoplasms / Q000628:therapy*; D013814:Thermal Conductivity
keywords: Finite element Runge-Kutta (4, 5) Method; Metabolic heat generation rate; Non-linear DPL bio-heat model; Thermal ablation; Vernotte number