title: Linking Long Noncoding RNA Localization and Function.
abstract: Recent studies have revealed the regulatory potential of many long noncoding RNAs (lncRNAs). Most lncRNAs, like mRNAs, are transcribed by RNA polymerase II and are capped, polyadenylated, and spliced. However, the subcellular fates of lncRNAs are distinct and the mechanisms of action are diverse. Investigating the mechanisms that determine the subcellular fate of lncRNAs has the potential to provide new insights into their biogenesis and specialized functions.
authors: State Key Laboratory of Molecular Biology, CAS Center for Excellence in Molecular Cell Science, Shanghai Key Laboratory of Molecular Andrology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China; School of Life Science and Technology, Shanghai Tech University, 100 Haike Road, Shanghai, China. Electronic address: linglingchen@sibcb.ac.cn.
authors: Ling-Ling
authors: LL
authors: Chen
mesh_terms: D006801:Humans; D034443:RNA Transport; D062085:RNA, Long Noncoding / Q000235:genetics / Q000378:metabolism*
chemical_list: D062085:RNA, Long Noncoding
keywords: long noncoding RNA biogenesis; long noncoding RNAs; nuclear retention; subcellular localization