title: Protocol for a national blood transfusion data warehouse from donor to recipient.
abstract: Blood transfusion has health-related, economical and safety implications. In order to optimise the transfusion chain, comprehensive research data are needed. The Dutch Transfusion Data warehouse (DTD) project aims to establish a data warehouse where data from donors and transfusion recipients are linked. This paper describes the design of the data warehouse, challenges and illustrative applications.
  
  
  
  Quantitative data on blood donors (eg, age, blood group, antibodies) and products (type of product, processing, storage time) are obtained from the national blood bank. These are linked to data on the transfusion recipients (eg, transfusions administered, patient diagnosis, surgical procedures, laboratory parameters), which are extracted from hospital electronic health records.
  
  
  
  Expected scientific contributions are illustrated for 4 applications: determine risk factors, predict blood use, benchmark blood use and optimise process efficiency. For each application, examples of research questions are given and analyses planned.
  
  
  
  The DTD project aims to build a national, continuously updated transfusion data warehouse. These data have a wide range of applications, on the donor/production side, recipient studies on blood usage and benchmarking and donor-recipient studies, which ultimately can contribute to the efficiency and safety of blood transfusion.
authors: Transfusion Technology Assessment Department, Sanquin Research, Amsterdam, The Netherlands Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands.
authors: Loan R
authors: LR
authors: van Hoeven
authors: Department of Public and Occupational Health, EMGO Institute for Health and Care Research, VU University Medical Center, Amsterdam, The Netherlands.
authors: Babette H
authors: BH
authors: Hooftman
authors: Transfusion Technology Assessment Department, Sanquin Research, Amsterdam, The Netherlands Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands.
authors: Mart P
authors: MP
authors: Janssen
authors: Department of Public and Occupational Health, EMGO Institute for Health and Care Research, VU University Medical Center, Amsterdam, The Netherlands.
authors: Martine C
authors: MC
authors: de Bruijne
authors: Department of Clinical Chemistry and Haematology, University Medical Center Utrecht, Utrecht, The Netherlands.
authors: Karen M K
authors: KM
authors: de Vooght
authors: Transfusion Technology Assessment Department, Sanquin Research, Amsterdam, The Netherlands.
authors: Peter
authors: P
authors: Kemper
authors: Department of Transfusion Medicine, Sanquin Blood Bank, Amsterdam, The Netherlands.
authors: Maria M W
authors: MM
authors: Koopman
mesh_terms: D001782:Blood Donors; D001803:Blood Transfusion; D003625:Data Collection; D000073458:Data Warehousing / Q000379:methods* / Q000592:standards; D005069:Evaluation Studies as Topic; D006801:Humans; D009426:Netherlands; D012107:Research Design; D012307:Risk Factors
keywords: Donor-recipient link; Electronic health record data; National data warehouse