title: A clinical examination of the efficacy of preparation of Dr Michaels® (also branded as Soratinex®) products in the treatment of psoriasis.
abstract: Psoriasis is a chronic inflammatory disease with negative impacts both physically and psychologically. It is a common disorder affecting 2-3% of the total world population, in some cases causing changes to the nail and joints as well as skin lesions. The cutaneous manifestations of psoriasis can vary in morphology and severity and therapy should be tailored accordingly. The aim of the study was to investigate the efficacy of Dr Michaels® (Soratinex®) product line in the treatment of psoriatic patients with different age and disease severity. A total number of 270 patients with verified psoriasis, aged 9-60 years old participated in the studies, including 128 children: 23 girls and 105 boys, (all of them selected from the Department of Dermato-allergology of the Russian Pediatric Hospital Clinic, Moscow, and of the 4th Department of Dermatology of the 52nd Moscow City Hospital Clinic). The patients were separated into 3 groups according to the severity of the disease (based on the PASI-index). All the patients have been treated with Dr Michaels® (Soratinex®) products twice daily, as three different forms were available for application: a cleansing gel, an ointment and a conditioner. The severity of the disease and the efficacy of the treatment have been defined with the evaluation of the PASI index of each patient. The obtained results were recorded in a graphic form showing the changes of the PASI-index on days 3, 7, 14, and 21 counted from the start of the trial. Clinical remission was achieved in 147 patients, a significant improvement in 73, partial improvement in 32, while no effect was seen in 12 patients and deterioration in 6. This open trial demonstrated the clinical efficacy of topical application of Dr Michaels® (Soratinex®) preparation. We observed clinical remissions of psoriasis in adults and in children.
authors: 2nd Medical Faculty, Charles University, Bulovka Hospital, Institute of Clinical and Experimental Medicine, Prague, Czech Republic.
authors: J
authors: J
authors: Hercogovấ
authors: Department of Nuclear Physics, Sub-nuclear and Radiation, G. Marconi University, Rome, Italy.
authors: M
authors: M
authors: Fioranelli
authors: Dermatological Department University of Pisa, Pisa, Italy.
authors: S
authors: S
authors: Gianfaldoni
authors: Onkoderma-Policlinic for dermatology and dermatologic surgery, Sofia, Bulgaria; Department of Dermatology and Venereology, Medical University of Plovdiv, Medical faculty, Plovdiv, Bulgaria.
authors: A A
authors: AA
authors: Chokoeva
authors: Medical Institute of Ministry of Interior (MVR), Department of Dermatology, Venereology and Dermatologic Surgery, Sofia, Bulgaria.
authors: G
authors: G
authors: Tchernev
authors: Department of Dermatology and Allergology, Academic Teaching Hospital Dresden-Friedrichstadt, Dresden, Germany.
authors: U
authors: U
authors: Wollina
authors: Psoriasis and Skin Clinic, Melbourne, Australia.
authors: M
authors: M
authors: Tirant
authors: PRO SANUM Ltd, Sanatorium of Prof. Novotný, Štěpánská Prague 1, Czech Republic.
authors: F
authors: F
authors: Novotny
authors: University B.I.S. Group of Institutions, Punjab Technical University, Punjab, India.
authors: M G
authors: MG
authors: Roccia
authors: Department Medicinal Information and Non-interventional studies, Bulgarian Drug Agency Sofia, Bulgaria.
authors: G K
authors: GK
authors: Maximov
authors: Department of Dermatology and Cutaneous Surgery, Department of Psychiatry and Behavioral Sciences, Institute for Bioethics and Health Policy, University of Miami, Miller School of Medicine - Miami, FL, USA; Centro Studi per la Ricerca Multidisciplinare e Rigenerativa. Università Degli Studi "G. Marconi", Rome, Italy.
authors: K
authors: K
authors: França
authors: Chair of Dermatology, University of Rome G. Marconi Rome, Italy.
authors: T
authors: T
authors: Lotti
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D002908:Chronic Disease / Q000628:therapy; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009031:Moscow; D008517:Phytotherapy; D011565:Psoriasis / Q000188:drug therapy* / Q000473:pathology*; D012720:Severity of Illness Index; D017592:Skin Care / Q000379:methods; D016896:Treatment Outcome; D055815:Young Adult