title: FOXP2 Expression in Frontotemporal Lobar Degeneration-Tau.
abstract: FOXP2 is altered in a variety of language disorders. We found reduced mRNA and protein expression of FOXP2 in frontal cortex area 8 in Pick's disease, and frontotemporal lobar degeneration-tau linked to P301L mutation presenting with language impairment in comparison with age-matched controls and cases with parkinsonian variant progressive supranuclear palsy. Foxp2 mRNA and protein are also reduced with disease progression in the somatosensory cortex in transgenic mice bearing the P301S mutation in MAPT when compared with wild-type littermates. Our findings support the presence of FOXP2 expression abnormalities in sporadic and familial frontotemporal degeneration tauopathies.
authors: Institute of Neuropathology, Bellvitge University Hospital-IDIBELL, L'Hospitalet de Llobregat, Barcelona, Spain.
authors: Irene
authors: I
authors: López-González
authors: Universidade Federal de Ciências da Saúde de Porto Alegre (UFCSPA), Porto Alegre, Brazil.
authors: Andre
authors: A
authors: Palmeira
authors: Institute of Neuropathology, Bellvitge University Hospital-IDIBELL, L'Hospitalet de Llobregat, Barcelona, Spain.
authors: Ester
authors: E
authors: Aso
authors: Institute of Neuropathology, Bellvitge University Hospital-IDIBELL, L'Hospitalet de Llobregat, Barcelona, Spain.
authors: Margarita
authors: M
authors: Carmona
authors: Universidade Federal de Ciências da Saúde de Porto Alegre (UFCSPA), Porto Alegre, Brazil.
authors: Liana
authors: L
authors: Fernandez
authors: Institute of Neuropathology, Bellvitge University Hospital-IDIBELL, L'Hospitalet de Llobregat, Barcelona, Spain.|University of Barcelona, L'Hospitalet de Llobregat, Barcelona, Spain.|CIBERNED, Instituto Carlos III, Madrid, Spain.
authors: Isidro
authors: I
authors: Ferrer
mesh_terms: D000818:Animals; D051858:Forkhead Transcription Factors / Q000096:biosynthesis* / Q000235:genetics; D005625:Frontal Lobe / Q000378:metabolism / Q000473:pathology; D057180:Frontotemporal Dementia / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D015870:Gene Expression; D006801:Humans; D008297:Male; D051379:Mice; D008822:Mice, Transgenic; D016875:tau Proteins / Q000096:biosynthesis* / Q000235:genetics
chemical_list: C465448:FOXP2 protein, human; D051858:Forkhead Transcription Factors; C054369:MAPT protein, human; D016875:tau Proteins
keywords: FOXP2; P301S transgenic mice; Pick’s disease; frontotemporal lobar degeneration; language; tauopathy