title: Effects of Platelet-Derived Endothelial Cell Growth Factor and Doppler Perfusion Index in Patients with Colorectal Hepatic Metastases.
abstract: BACKGROUND
  We aimed to find out if there is a correlation between Doppler perfusion index (DPI) and platelet- derived endothelial cell growth factor (PD-ECGF), which is an angiogenic factor with angiopoietic function, in patients with colorectal carcinoma.
  
  
  METHODS
  50 colorectal carcinoma patients (22 cases with liver metastases, 28 cases without liver metastases) and 50 healthy controls were assessed with Doppler ultrasound as a preoperative evaluation. PD-ECGF expression in postoperative specimens of the 50 cases with colorectal carcinoma was assayed by immunohistochemistry and real-time polymerase chain reaction methods.
  
  
  RESULTS
  The mean DPI value was 0.29 ± 0.05 in patients suffering from colon cancer with hepatic metastases and 0.12 ± 0.03 in the healthy control group. The DPI value was significantly higher in patients with liver metastases (p < 0.05). PD-ECGF expression in patients with colorectal liver metastases was significantly higher than that in the group without liver metastases (p < 0.05). A positive correlation was found between DPI value and PD-ECGF expression in patients with liver metastases (p < 0.05).
  
  
  CONCLUSIONS
  DPI and PD-ECGF may be valuable factors when screening hepatic metastases in patients with colorectal cancer and serve as practical measurements in postoperative follow-up.
authors: Department of General Surgery, Tianjin Medical University General Hospital, Tianjin, China, Tianjin, China.
authors: Xueming
authors: X
authors: Jiang
authors: Department of General Surgery, Tianjin Medical University General Hospital, Tianjin, China, Tianjin, China.
authors: Zhixiang
authors: Z
authors: Zhang
authors: Tianjin General Surgery Institute, Tianjin Medical University General Hospital, Tianjin, China.
authors: Na
authors: N
authors: Zhao
authors: Department of General Surgery, Tianjin Medical University General Hospital, Tianjin, China, Tianjin, China; Tianjin General Surgery Institute, Tianjin Medical University General Hospital, Tianjin, China.
authors: Xianghui
authors: X
authors: He
authors: Department of General Surgery, Tianjin Medical University General Hospital, Tianjin, China, Tianjin, China; Tianjin General Surgery Institute, Tianjin Medical University General Hospital, Tianjin, China.
authors: Hao
authors: H
authors: Guo
keywords: Colorectal neoplasms; Doppler perfusion index, DPI; Hepatic metastases; Platelet-derived endothelial cell growth factor, PD-ECGF