title: Preparation of fluorescent organic nanoparticles from polyethylenimine and sucrose for cell imaging.
abstract: An approach for the synthesis of fluorescent organic nanoparticles (FONs) with a quantum yield of about 14% has been developed using polyethylenimine and sucrose. The FONs were prepared under mild reaction condition. The obtained FONs showed high water dispersibility, intense fluorescence, excitation-dependent emission feature, excellent nanoparticle stability, and high photostability. The cytotoxicity of the FONs was also evaluated using A549 cells, and the cell viability value was demonstrated greater than 90% even when the concentration was up to 120μgmL(-1), which proved excellent biocompatibility and made them promising for cell imaging.
authors: College of Materials & Metallurgical Engineering, Guizhou Institute of Technology, Guiyang 550003, PR China. Electronic address: machunpingaa@126.com.
authors: Chunping
authors: C
authors: Ma
authors: Laboratory of Bio-Inspired Smart Interface Science, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100190, PR China; Department of Chemistry, Tsinghua Center for Frontier Polymer Research, Tsinghua University, Beijing 100084, PR China. Electronic address: xqzhang@mail.ipc.ac.cn.
authors: Xiqi
authors: X
authors: Zhang
authors: College of Materials & Metallurgical Engineering, Guizhou Institute of Technology, Guiyang 550003, PR China.
authors: Liutao
authors: L
authors: Yang
authors: College of Materials & Metallurgical Engineering, Guizhou Institute of Technology, Guiyang 550003, PR China.
authors: Yujiao
authors: Y
authors: Wu
authors: Laboratory of Bio-Inspired Smart Interface Science, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100190, PR China.
authors: Hongliang
authors: H
authors: Liu
authors: Department of Chemistry, Tsinghua Center for Frontier Polymer Research, Tsinghua University, Beijing 100084, PR China.
authors: Xiaoyong
authors: X
authors: Zhang
authors: Department of Chemistry, Tsinghua Center for Frontier Polymer Research, Tsinghua University, Beijing 100084, PR China. Electronic address: weiyen@tsinghua.edu.cn.
authors: Yen
authors: Y
authors: Wei
mesh_terms: D045744:Cell Line, Tumor; D003603:Cytotoxins / Q000737:chemistry / Q000494:pharmacology; D005456:Fluorescent Dyes / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D008422:Materials Testing; D053758:Nanoparticles / Q000737:chemistry*; D011094:Polyethyleneimine / Q000737:chemistry / Q000494:pharmacology
chemical_list: D003603:Cytotoxins; D005456:Fluorescent Dyes; D011094:Polyethyleneimine
keywords: Biocompatibility; Cell imaging; Fluorescent organic nanoparticles; Polyethylenimine; Sucrose