title: Sarcoptic mange in dogs: Its effect on liver, oxidative stress, trace minerals and vitamins.
abstract: The present study was aimed to determine the effect on liver, associated oxidative stress, trace element and vitamin alteration in dogs with sarcoptic mange. A total of 24 dogs with clinically established diagnosis of sarcoptic mange, divided into two groups, severely infested group (n=9) and mild/moderately infested group (n=15), according to the extent of skin lesions caused by sarcoptic mange and 6 dogs as control group were included in the present study. In comparison to healthy control hemoglobin, PCV, and TEC were significantly (P<0.05) decreased in dogs with sarcoptic mange however, significant increase in TLC along with neutrophilia and lymphopenia was observed only in severely infested dogs. The albumin, glucose and cholesterol were significantly (P<0.05) decreased and globulin, ALT, AST and bilirubin were significantly (P<0.05) increased in severely infested dogs when compared to other two groups. Malondialdehyde (MDA) levels were significantly (P<0.01) higher in dogs with sarcoptic mange, with levels highest in severely infested groups. Activity of superoxide dismutase (SOD) (P<0.05) and catalase were significantly (P<0.01) lower in sarcoptic infested dogs when compared with the healthy control group. Zinc and copper levels in dogs with sarcoptic mange were significantly (P<0.05) lower when compared with healthy control group with the levels lowest in severely infested group. Vitamin A and vitamin C levels were significantly (P<0.05) lower in sarcoptic infested dogs when compared to healthy control. From the present study, it was concluded that sarcoptic mange in dogs affects the liver and the infestation is associated with oxidant/anti-oxidant imbalance, significant alteration in trace elements and vitamins.
authors: Department of Clinical Veterinary Medicine, Ethics & Jurisprudence, Faculty of Veterinary Science and Animal Husbandry, Shere-e-Kashmir University of Agricultural Sciences and Technology of Kashmir, Shalimar Campus, Srinagar-191121, J&K, India. Electronic address: shafullah@gmail.com.
authors: S A
authors: SA
authors: Beigh
authors: Division of Teaching Veterinary Clinical Complex, Faculty of Veterinary Science and Animal Husbandry, Shere-e-Kashmir University of Agricultural Sciences and Technology of Jammu, R.S. Pura 181102, Jammu, J&K, India.
authors: J S
authors: JS
authors: Soodan
authors: Department of Clinical Veterinary Medicine, Ethics & Jurisprudence, Faculty of Veterinary Science and Animal Husbandry, Shere-e-Kashmir University of Agricultural Sciences and Technology of Kashmir, Shalimar Campus, Srinagar-191121, J&K, India.
authors: A M
authors: AM
authors: Bhat
mesh_terms: D000818:Animals; D016022:Case-Control Studies; D004283:Dog Diseases / Q000473:pathology*; D004285:Dogs; D005260:Female; D008099:Liver / Q000201:enzymology* / Q000378:metabolism; D008297:Male; D018384:Oxidative Stress; D012532:Scabies / Q000097:blood / Q000473:pathology / Q000662:veterinary*; D014131:Trace Elements / Q000097:blood*; D014815:Vitamins / Q000097:blood*
chemical_list: D014131:Trace Elements; D014815:Vitamins
keywords: Dogs; Oxidative stress; Sarcoptic mange; Trace elements; Vitamin A and vitamin C