title: Local modulation of human brain responses by circadian rhythmicity and sleep debt.
abstract: Human performance is modulated by circadian rhythmicity and homeostatic sleep pressure. Whether and how this interaction is represented at the regional brain level has not been established. We quantified changes in brain responses to a sustained-attention task during 13 functional magnetic resonance imaging sessions scheduled across the circadian cycle, during 42 hours of wakefulness and after recovery sleep, in 33 healthy participants. Cortical responses showed significant circadian rhythmicity, the phase of which varied across brain regions. Cortical responses also significantly decreased with accrued sleep debt. Subcortical areas exhibited primarily a circadian modulation that closely followed the melatonin profile. These findings expand our understanding of the mechanisms involved in maintaining cognition during the day and its deterioration during sleep deprivation and circadian misalignment.
authors: GIGA-Cyclotron Research Centre-In Vivo Imaging, University of Liège, Liège, Belgium. Walloon Excellence in Life Sciences and Biotechnology (WELBIO), Liège, Belgium. Psychology and Cognitive Neuroscience Research Unit, University of Liège, Liège, Belgium.
authors: Vincenzo
authors: V
authors: Muto
authors: GIGA-Cyclotron Research Centre-In Vivo Imaging, University of Liège, Liège, Belgium. Walloon Excellence in Life Sciences and Biotechnology (WELBIO), Liège, Belgium. Psychology and Cognitive Neuroscience Research Unit, University of Liège, Liège, Belgium.
authors: Mathieu
authors: M
authors: Jaspar
authors: GIGA-Cyclotron Research Centre-In Vivo Imaging, University of Liège, Liège, Belgium. Walloon Excellence in Life Sciences and Biotechnology (WELBIO), Liège, Belgium.
authors: Christelle
authors: C
authors: Meyer
authors: GIGA-Cyclotron Research Centre-In Vivo Imaging, University of Liège, Liège, Belgium. Walloon Excellence in Life Sciences and Biotechnology (WELBIO), Liège, Belgium.
authors: Caroline
authors: C
authors: Kussé
authors: GIGA-Cyclotron Research Centre-In Vivo Imaging, University of Liège, Liège, Belgium. Walloon Excellence in Life Sciences and Biotechnology (WELBIO), Liège, Belgium.
authors: Sarah L
authors: SL
authors: Chellappa
authors: GIGA-Cyclotron Research Centre-In Vivo Imaging, University of Liège, Liège, Belgium. Walloon Excellence in Life Sciences and Biotechnology (WELBIO), Liège, Belgium.
authors: Christian
authors: C
authors: Degueldre
authors: GIGA-Cyclotron Research Centre-In Vivo Imaging, University of Liège, Liège, Belgium. Walloon Excellence in Life Sciences and Biotechnology (WELBIO), Liège, Belgium.
authors: Evelyne
authors: E
authors: Balteau
authors: GIGA-Cyclotron Research Centre-In Vivo Imaging, University of Liège, Liège, Belgium. Walloon Excellence in Life Sciences and Biotechnology (WELBIO), Liège, Belgium.
authors: Anahita
authors: A
authors: Shaffii-Le Bourdiec
authors: GIGA-Cyclotron Research Centre-In Vivo Imaging, University of Liège, Liège, Belgium. Walloon Excellence in Life Sciences and Biotechnology (WELBIO), Liège, Belgium.
authors: André
authors: A
authors: Luxen
authors: Faculty of Health and Medical Sciences, University of Surrey, Guildford, UK.
authors: Benita
authors: B
authors: Middleton
authors: Sleep Research Centre, Faculty of Health and Medical Sciences, University of Surrey, Guildford, UK.
authors: Simon N
authors: SN
authors: Archer
authors: GIGA-Cyclotron Research Centre-In Vivo Imaging, University of Liège, Liège, Belgium. Walloon Excellence in Life Sciences and Biotechnology (WELBIO), Liège, Belgium. Sleep Research Centre, Faculty of Health and Medical Sciences, University of Surrey, Guildford, UK.
authors: Christophe
authors: C
authors: Phillips
authors: GIGA-Cyclotron Research Centre-In Vivo Imaging, University of Liège, Liège, Belgium. Walloon Excellence in Life Sciences and Biotechnology (WELBIO), Liège, Belgium. Psychology and Cognitive Neuroscience Research Unit, University of Liège, Liège, Belgium.
authors: Fabienne
authors: F
authors: Collette
authors: GIGA-Cyclotron Research Centre-In Vivo Imaging, University of Liège, Liège, Belgium. Walloon Excellence in Life Sciences and Biotechnology (WELBIO), Liège, Belgium.
authors: Gilles
authors: G
authors: Vandewalle
authors: Sleep Research Centre, Faculty of Health and Medical Sciences, University of Surrey, Guildford, UK.
authors: Derk-Jan
authors: DJ
authors: Dijk
authors: GIGA-Cyclotron Research Centre-In Vivo Imaging, University of Liège, Liège, Belgium. Walloon Excellence in Life Sciences and Biotechnology (WELBIO), Liège, Belgium. Department of Neurology, CHU Liège, Liège, Belgium. pmaquet@ulg.ac.be.
authors: Pierre
authors: P
authors: Maquet
mesh_terms: D000293:Adolescent; D000328:Adult; D001288:Attention; D002540:Cerebral Cortex / Q000502:physiology*; D002940:Circadian Rhythm; D003071:Cognition; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008550:Melatonin; D012890:Sleep / Q000502:physiology*; D012892:Sleep Deprivation / Q000503:physiopathology*; D014851:Wakefulness; D055815:Young Adult
chemical_list: D008550:Melatonin