title: Evaluation of the New World Health Organization Case Definition of Severe Acute Respiratory Infection for Influenza Surveillance During the Peak Weeks of Two Influenza Seasons in Quebec, Canada.
abstract: During the peak of the 2012-2013 and 2014-2015 influenza seasons in Quebec, Canada, the sensitivity of the new World Health Organization (WHO) case definition of severe acute respiratory infection (SARI) in <5-year-old children was 65% for polymerase chain reaction-confirmed influenza and 79% for other respiratory viruses (ORVs), whereas its specificity and positive predictive value were approximately 2- and 4-fold lower for influenza than ORVs (25% vs 40% and 18% vs 76%, respectively). The use of the WHO SARI definition for influenza surveillance in children should be interpreted with caution according to the specific surveillance goals.
authors: Institut National de Santé Publique du Québec.
authors: R
authors: R
authors: Amini
authors: Institut National de Santé Publique du Québec.|Centre Hospitalier Universitaire de Quebec.|Laval University, Quebec, Quebec City, Canada.
authors: R
authors: R
authors: Gilca
authors: Institut National de Santé Publique du Québec.|Centre Hospitalier Universitaire de Quebec.
authors: M
authors: M
authors: Douville-Fradet
authors: Institut National de Santé Publique du Québec.|Centre Hospitalier Universitaire de Quebec.
authors: N
authors: N
authors: Boulianne
authors: Institut National de Santé Publique du Québec.|Centre Hospitalier Universitaire de Quebec.|Laval University, Quebec, Quebec City, Canada.
authors: G
authors: G
authors: De Serres
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D002675:Child, Preschool; D004338:Drug Combinations; D005260:Female; D005459:Fluorides; D006801:Humans; D007223:Infant; D007251:Influenza, Human / Q000175:diagnosis* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D060885:Multiplex Polymerase Chain Reaction; D009566:Nitrates; D010710:Phosphates; D011159:Population Surveillance / Q000379:methods; D011792:Quebec / Q000453:epidemiology; D012140:Respiratory Tract Diseases / Q000175:diagnosis* / Q000473:pathology; D012621:Seasons; D014944:World Health Organization; D055815:Young Adult
chemical_list: D004338:Drug Combinations; D009566:Nitrates; D010710:Phosphates; C097427:Sensodyne; D005459:Fluorides
keywords: SARI case definition; influenza; other respiratory viruses; positive predictive value; sensitivity