title: Natural Products at Work: Structural Insights into Inhibition of the Bacterial Membrane Protein MraY.
abstract: Natural(ly) fit: The X-ray crystal structure of the bacterial membrane protein MraY in complex with its natural product inhibitor muraymycin D2 is discussed. MraY catalyzes one of the membrane-associated steps in peptidoglycan biosynthesis and, therefore, represents a promising target for novel antibiotics. Structural insights derived from the protein-inhibitor complex might now pave the way for the development of new antimicrobial drugs.
authors: Department of Pharmacy, Pharmaceutical and Medicinal Chemistry, Saarland University, Campus C2 3, 66123, Saarbrücken, Germany.
authors: Stefan
authors: 0000-0003-3905-4295
authors: S
authors: Koppermann
authors: Department of Pharmacy, Pharmaceutical and Medicinal Chemistry, Saarland University, Campus C2 3, 66123, Saarbrücken, Germany. christian.ducho@uni-saarland.de.
authors: Christian
authors: 0000-0002-0629-9993
authors: C
authors: Ducho
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology*; D001419:Bacteria / Q000737:chemistry / Q000187:drug effects / Q000201:enzymology* / Q000378:metabolism; D001424:Bacterial Infections / Q000188:drug therapy / Q000382:microbiology; D001426:Bacterial Proteins / Q000037:antagonists & inhibitors* / Q000737:chemistry / Q000378:metabolism; D001688:Biological Products / Q000737:chemistry / Q000494:pharmacology*; D018360:Crystallography, X-Ray; D006801:Humans; D062105:Molecular Docking Simulation; D009705:Nucleosides / Q000737:chemistry / Q000494:pharmacology*; D010455:Peptides / Q000737:chemistry / Q000494:pharmacology*; D010457:Peptidoglycan / Q000378:metabolism; D014166:Transferases / Q000037:antagonists & inhibitors* / Q000737:chemistry / Q000378:metabolism; D017855:Transferases (Other Substituted Phosphate Groups)
chemical_list: D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D001688:Biological Products; D009705:Nucleosides; D010455:Peptides; D010457:Peptidoglycan; C549119:muraymycin D2; D014166:Transferases; D017855:Transferases (Other Substituted Phosphate Groups); C079803:mraY protein, Bacteria
keywords: antibiotics; medicinal chemistry; natural products; peptidoglycans; protein crystallography