title: Evaluating the carotid bodies and renal nerves as therapeutic targets for hypertension.
abstract: Despite the plethora of current treatment options, hypertension remains a difficult condition to adequately control, and there is a pressing need for novel therapeutic strategies. The carotid body has recently become the focus of considerable interest as a potential novel treatment target in essential hypertension. Herein, we appraise the current literature suggesting that the carotid body plays an important causative role to generate sympathetic overactivity and drive increases in arterial pressure, in animal models of hypertension. We also review evidence from human studies showing cardiovascular benefits to the transient inactivation, or surgical removal of carotid bodies, and evaluate the potential benefits of pre-screening to identify patients likely to respond to carotid body-targeted therapy. Finally, given that a high proportion of patients who have undergone renal nerve ablation procedures remain hypertensive, we examine whether the renal nerves are necessary for the drop in blood pressure seen with carotid body removal.
authors: Department of Physiology, Faculty of Medical and Health Sciences, University of Auckland, New Zealand; School of Physiology, Pharmacology & Neuroscience, Biomedical Sciences, University of Bristol, Bristol, UK. Electronic address: f.mcbryde@auckland.ac.nz.
authors: Fiona D
authors: FD
authors: McBryde
authors: School of Physiology, Pharmacology & Neuroscience, Biomedical Sciences, University of Bristol, Bristol, UK.
authors: Emma C
authors: EC
authors: Hart
authors: Department of Physiology, Faculty of Medical and Health Sciences, University of Auckland, New Zealand.
authors: Rohit
authors: R
authors: Ramchandra
authors: Department of Physiology, Faculty of Medical and Health Sciences, University of Auckland, New Zealand; School of Physiology, Pharmacology & Neuroscience, Biomedical Sciences, University of Bristol, Bristol, UK.
authors: Julian F R
authors: JF
authors: Paton
mesh_terms: D000818:Animals; D002344:Carotid Body / Q000503:physiopathology* / Q000601:surgery*; D006801:Humans; D006973:Hypertension / Q000175:diagnosis / Q000503:physiopathology* / Q000601:surgery*; D007668:Kidney / Q000294:innervation* / Q000503:physiopathology / Q000601:surgery
keywords: Carotid body; Hypertension; Renal denervation; Sympathetic nervous system