title: Antidiabetic activity and chemical constituents of the aerial parts of Heracleum dissectum Ledeb.
abstract: Heracleum dissectum Ledeb. has long been used as a wild edible vegetable by local people in China. The purpose of this study is to investigate the antidiabetic potential of aerial part of H. dissectum methanol extract (HdME) and the chemical constituents. Ten compounds including eight coumarins were isolated and four of them were found from H. dissectum for the first time. HdME potently inhibited the elevation of plasma glucose after its oral administration to glucose-loaded mice, and its petroleum ether (PE) fraction exerted the greatest inhibitory activities. Meanwhile, HdME (125 and 250mg/kg) also significantly decreased the blood glucose level in STZ-induced diabetic mice, but had no effect in normoglycemic mice. Additionally, HdME showed weak inhibitory effects on α-glucosidase activity and DPPH free radicals scavenging. In conclusion, HdME has antidiabetic action and PE fraction is the active part where coumarins possibly play an important role in antidiabetic activity.
authors: School of Pharmacy, Xi'an Jiaotong University, Xi'an, China.
authors: Hailong
authors: H
authors: Zhang
authors: School of Pharmacy, Xi'an Jiaotong University, Xi'an, China; Department of Pharmacy, People's Hospital of Xintai City, Xintai, China.
authors: Yaping
authors: Y
authors: Su
authors: School of Pharmacy, Xi'an Jiaotong University, Xi'an, China.
authors: Xinrui
authors: X
authors: Wang
authors: School of Pharmacy, Xi'an Jiaotong University, Xi'an, China.
authors: Jie
authors: J
authors: Mi
authors: School of Pharmacy, Xi'an Jiaotong University, Xi'an, China.
authors: Yayu
authors: Y
authors: Huo
authors: Department of Pharmaceutical Analysis, Heilongjiang University of Chinese Medicine, Harbin, China.
authors: Zhigang
authors: Z
authors: Wang
authors: State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
authors: Ying
authors: Y
authors: Liu
authors: School of Pharmacy, Xi'an Jiaotong University, Xi'an, China. Electronic address: gaoyangyang@mail.xjtu.edu.cn.
authors: Yang
authors: Y
authors: Gao
mesh_terms: D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy*; D030002:Heracleum / Q000737:chemistry*; D007004:Hypoglycemic Agents / Q000737:chemistry*; D008297:Male; D051379:Mice; D035261:Plant Components, Aerial / Q000737:chemistry*; D010936:Plant Extracts / Q000737:chemistry*
chemical_list: D007004:Hypoglycemic Agents; D010936:Plant Extracts
keywords: Acarbose (PubChem CID 41774); Antidiabetes; Ascorbic acid (PubChem CID 54670067); Chemical constituents; DPPH (PubChem CID 2735032); Gliclazide (PubChem CID 3475); Glucose (PubChem CID 5793); Heracleum dissectum; Metformin (PubChem CID 4091); Oral glucose tolerance test; STZ-induced diabetic model; Streptozotocin (PubChem CID 29327)