title: Graphene-Fe3O4as a magnetic solid-phase extraction sorbent coupled to capillary electrophoresis for the determination of sulfonamides in milk.
abstract: Graphene-Fe3O4nanoparticles were prepared using one-step solvothermal method and characterized by X-ray diffraction, FTIR spectroscopy, scanning electron microscopy, and vibrating sample magnetometry. The results demonstrated that Fe3O4nanoparticles were homogeneously anchored on graphene nanosheets. The as-synthesized graphene-Fe3O4nanoparticles were employed as sorbent for magnetic solid-phase extraction of sulfonamides in milk prior to capillary electrophoresis analysis. The optimal capillary electrophoresis conditions were as follows: 60 mmol/L Na2HPO4containing 2 mmol/L ethylenediaminetetraacetic acid disodium salt and 24% v/v methanol as running buffer, separation voltage of 14 kV, and detection wavelength of 270 nm. The parameters affecting extraction efficiency including desorption solution, the amount of graphene-Fe3O4nanoparticles, extraction time, and sample pH were investigated in detail. Under the optimal conditions, good linearity (5-200 μg/L) with correlation coefficients ≥0.9910 was obtained. The limits of detection were 0.89-2.31 μg/L. The relative standard deviations for intraday and interday analyses were 4.9-8.5 and 4.0-9.0%, respectively. The proposed method was successfully applied to the analysis of sulfonamides in milk samples with recoveries ranging from 62.7 to 104.8% and relative standard deviations less than 10.2%.
authors: College of Chemistry and Life Science, Zhejiang Normal University, Jinhua, China.
authors: Zhaoqian
authors: Z
authors: Li
authors: College of Chemistry and Life Science, Zhejiang Normal University, Jinhua, China.
authors: Yazhen
authors: Y
authors: Li
authors: College of Chemistry and Life Science, Zhejiang Normal University, Jinhua, China.
authors: Mengyu
authors: M
authors: Qi
authors: College of Chemistry and Life Science, Zhejiang Normal University, Jinhua, China.
authors: Shuxian
authors: S
authors: Zhong
authors: College of Chemistry and Life Science, Zhejiang Normal University, Jinhua, China. wangwp@zjnu.edu.cn.
authors: Weiping
authors: W
authors: Wang
authors: College of Geography and Environmental Science, Zhejiang Normal University, Jinhua, China.
authors: Ai-Jun
authors: AJ
authors: Wang
authors: College of Geography and Environmental Science, Zhejiang Normal University, Jinhua, China.
authors: Jianrong
authors: J
authors: Chen
mesh_terms: D000327:Adsorption; D000818:Animals; D002417:Cattle; D019075:Electrophoresis, Capillary / Q000379:methods*; D005506:Food Contamination / Q000032:analysis; D006108:Graphite / Q000737:chemistry*; D058185:Magnetite Nanoparticles / Q000737:chemistry; D008892:Milk / Q000737:chemistry*; D052616:Solid Phase Extraction / Q000295:instrumentation / Q000379:methods*; D013449:Sulfonamides / Q000737:chemistry* / Q000302:isolation & purification*
chemical_list: D058185:Magnetite Nanoparticles; D013449:Sulfonamides; D006108:Graphite
keywords: Graphene-Fe3O4 nanoparticles; Magnetic solid phase extraction; Milk samples; Sulfonamides