title: Therapeutic potential of mesenchymal stem cell based therapy for osteoarthritis.
abstract: Osteoarthritis (OA) is a chronic degenerative disease affecting articular cartilage in joints, and it is a leading cause of disability in the United States. Current pharmacological treatment strategies are ineffective to prevent the OA progression; however, cellular therapies have the potential to regenerate the lost cartilage, combat cartilage degeneration, provide pain relief, and improve patient mobility. One of the most promising sources of cellular regenerative medicine is from mesenchymal stem cells (MSCs). MSCs can be isolated from adipose tissue, bone marrow, synovial tissue, and other sources. The aim of this review is to compile recent advancement in cellular based therapy more specifically in relation to MSCs in the treatment of osteoarthritis.
authors: Department of Orthopedics, Georgia Regents University, Augusta, GA, USA.
authors: John
authors: J
authors: Burke
authors: Department of Orthopedics, Georgia Regents University, Augusta, GA, USA.
authors: Monte
authors: M
authors: Hunter
authors: Department of Pathology, Georgia Regents University, Augusta, GA, USA.
authors: Ravindra
authors: R
authors: Kolhe
authors: Department of Orthopedics, Georgia Regents University, Augusta, GA, USA.|Institute of Regenerative and Reparative Medicine, Georgia Regents University, Augusta, GA, USA.
authors: Carlos
authors: C
authors: Isales
authors: Department of Cell Biology and Anatomy, Georgia Regents University, Augusta, GA, USA.|Institute of Regenerative and Reparative Medicine, Georgia Regents University, Augusta, GA, USA.
authors: Mark
authors: M
authors: Hamrick
authors: Department of Orthopedics, Georgia Regents University, Augusta, GA, USA. sfulzele@augusta.edu.|Institute of Regenerative and Reparative Medicine, Georgia Regents University, Augusta, GA, USA. sfulzele@augusta.edu.|Department of Orthopedics Surgery, Augusta University, Augusta, GA, 30904, USA. sfulzele@augusta.edu.
authors: Sadanand
authors: http://orcid.org/0000-0002-3510-6759
authors: S
authors: Fulzele
keywords: ADSC; Cell therapy; Osteoarthritis; Stem cell