title: CA19-9-related tumor kinetics after first-line chemotherapy of patients with advanced pancreatic cancer: a monoinstitutional experience.
abstract: The absolute value of carbohydrate antigen 19-9 (CA19-9) pretreatment and its reduction after chemotherapy are established prognostic variables for patients with advanced pancreatic cancer. The present study is a retrospective monoinstitutional evaluation of the prognostic role of the CA19-9 reduction and some CA19-9-related tumor kinetics parameters, such as tumor growth rate constant (G), kinetic tumor response and log ratio. Forty-one cases met the selection criteria. After 8 weeks only G reported an inverse relationship with OS (r = -0.494) that was confirmed by regression analysis (R (2) = 0.192). G after 8 weeks of chemotherapy appears as a possible surrogate end point of overall survival.
authors: Department of Oncology, G. Borea Hospital, Via G. Borea, 56, 18038, Sanremo, Imperia, Italy. g.colloca@katamail.com.
authors: Giuseppe
authors: http://orcid.org/0000-0002-0903-6793
authors: G
authors: Colloca
authors: Department of Oncology, G. Borea Hospital, Via G. Borea, 56, 18038, Sanremo, Imperia, Italy.
authors: Antonella
authors: A
authors: Venturino
authors: Department of Oncology, G. Borea Hospital, Via G. Borea, 56, 18038, Sanremo, Imperia, Italy.
authors: Domenico
authors: D
authors: Guarneri
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D015295:Antigens, Tumor-Associated, Carbohydrate / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010190:Pancreatic Neoplasms / Q000097:blood* / Q000188:drug therapy* / Q000473:pathology; D012189:Retrospective Studies
chemical_list: D015295:Antigens, Tumor-Associated, Carbohydrate; C578959:carbohydrate antigen 199, human
keywords: CA19-9; Chemotherapy; Pancreatic cancer; Serologic response; Tumor growth rate