title: Effects of nasal drug delivery device and its orientation on sprayed particle deposition in a realistic human nasal cavity.
abstract: In this study, the effects of nasal drug delivery device and the spray nozzle orientation on sprayed droplets deposition in a realistic human nasal cavity were numerically studied. Prior to performing the numerical investigation, an in-house designed automated actuation system representing mean adults actuation force was developed to produce realistic spray plume. Then, the spray plume development was filmed by high speed photography system, and spray characteristics such as spray cone angle, break-up length, and average droplet velocity were obtained through off-line image analysis. Continuing studies utilizing those experimental data as boundary conditions were applied in the following numerical spray simulations using a commercially available nasal spray device, which was inserted into a realistic adult nasal passage with external facial features. Through varying the particle releasing direction, the deposition fractions of selected particle sizes on the main nasal passage for targeted drug delivery were compared. The results demonstrated that the middle spray direction showed superior spray efficiency compared with upper or lower directions, and the 10µm agents were the most suitable particle size as the majority of sprayed agents can be delivered to the targeted area, the main passage. This study elaborates a comprehensive approach to better understand nasal spray mechanism and evaluate its performance for existing nasal delivery practices. Results of this study can assist the pharmaceutical industry to improve the current design of nasal drug delivery device and ultimately benefit more patients through optimized medications delivery.
authors: School of Engineering, RMIT University, PO Box 71, Bundoora, VIC 3083, Australia.
authors: Xuwen
authors: X
authors: Tong
authors: School of Engineering, RMIT University, PO Box 71, Bundoora, VIC 3083, Australia.
authors: Jingliang
authors: J
authors: Dong
authors: School of Engineering, RMIT University, PO Box 71, Bundoora, VIC 3083, Australia.
authors: Yidan
authors: Y
authors: Shang
authors: School of Engineering, RMIT University, PO Box 71, Bundoora, VIC 3083, Australia.
authors: Kiao
authors: K
authors: Inthavong
authors: School of Engineering, RMIT University, PO Box 71, Bundoora, VIC 3083, Australia. Electronic address: jiyuan.tu@rmit.edu.au.
authors: Jiyuan
authors: J
authors: Tu
mesh_terms: D000281:Administration, Intranasal / Q000379:methods*; D000328:Adult; D000336:Aerosols / Q000008:administration & dosage*; D003198:Computer Simulation; D016503:Drug Delivery Systems / Q000379:methods*; D004867:Equipment Design; D006801:Humans; D008297:Male; D008953:Models, Anatomic; D009296:Nasal Cavity / Q000033:anatomy & histology / Q000000981:diagnostic imaging
chemical_list: D000336:Aerosols
keywords: Atomization; Deposition fraction; Medications delivery; Nasal spray