title: Significance of Pharmacogenetics and Pharmacogenomics Research in Current Medical Practice.
abstract: Human genome sequencing highlights the involvement of genetic variation towards differential risk of human diseases, presence of different phenotypes, and response to pharmacological elements. This brings the field of personalized medicine to forefront in the era of modern health care. Numerous recent approaches have shown that how variation in the genome at single nucleotide level can be used in pharmacological research. The two broad aspects that deal with pharmacological research are pharmacogenetics and pharmacogenomics. This review encompasses how these variations have created the basis of pharmacogenetics and pharmacogenomics research and important milestones accomplished in these two fields in different diseases. It further discusses at length their importance in disease diagnosis, response of drugs, and various treatment modalities on the basis of genetic determinants.
authors: Swayam
authors: S
authors: Prakash
authors: Department of Medical Genetics, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Raebareli Road, Lucknow (UP) 226014 India.
authors: Suraksha
authors: S
authors: Agrawal
mesh_terms: D000818:Animals; D035843:Biomedical Research; D004305:Dose-Response Relationship, Drug; D006801:Humans; D004364:Pharmaceutical Preparations / Q000378:metabolism; D010597:Pharmacogenetics; D000071184:Pharmacogenomic Variants
chemical_list: D004364:Pharmaceutical Preparations