title: Phylogenetic-Derived Insights into the Evolution of Sialylation in Eukaryotes: Comprehensive Analysis of Vertebrate β-Galactoside α2,3/6-Sialyltransferases (ST3Gal and ST6Gal).
abstract: Cell surface of eukaryotic cells is covered with a wide variety of sialylated molecules involved in diverse biological processes and taking part in cell-cell interactions. Although the physiological relevance of these sialylated glycoconjugates in vertebrates begins to be deciphered, the origin and evolution of the genetic machinery implicated in their biosynthetic pathway are poorly understood. Among the variety of actors involved in the sialylation machinery, sialyltransferases are key enzymes for the biosynthesis of sialylated molecules. This review focus on β-galactoside α2,3/6-sialyltransferases belonging to the ST3Gal and ST6Gal families. We propose here an outline of the evolutionary history of these two major ST families. Comparative genomics, molecular phylogeny and structural bioinformatics provided insights into the functional innovations in sialic acid metabolism and enabled to explore how ST-gene function evolved in vertebrates.
authors: Bioinformatics Unit, Fundación Instituto Leloir, Av. Patricias Argentinas 435, C1405BWE Buenos Aires, Argentina. elinteppa@gmail.com.
authors: Roxana E
authors: RE
authors: Teppa
authors: Laboratoire de Génétique Moléculaire Animale, UMR 1061 INRA, Université de Limoges Faculté des Sciences et Techniques, 123 avenue Albert Thomas, 87060 Limoges, France. daniel.petit@unilim.fr.
authors: Daniel
authors: D
authors: Petit
authors: FRABio-FR3688 CNRS, Univ. Lille, bât. C9, 59655 Villeneuve d'Ascq cedex, France. olga.plechakova@univ-lille1.fr.
authors: Olga
authors: O
authors: Plechakova
authors: Univ. Lille, CNRS, UMR 8576-UGSF-Unité de Glycobiologie Structurale et Fonctionnelle, 59000 Lille, France. virginie.cogez@univ-lille1.fr.
authors: Virginie
authors: V
authors: Cogez
authors: Univ. Lille, CNRS, UMR 8576-UGSF-Unité de Glycobiologie Structurale et Fonctionnelle, 59000 Lille, France. anne.harduin@univ-lille1.fr.|UGSF, Bât. C9, Université de Lille-Sciences et Technologies, 59655 Villeneuve d'Ascq, France. anne.harduin@univ-lille1.fr.
authors: Anne
authors: A
authors: Harduin-Lepers
mesh_terms: D000818:Animals; D019158:N-Acetylneuraminic Acid / Q000378:metabolism; D010802:Phylogeny; D012799:Sialyltransferases / Q000145:classification / Q000235:genetics / Q000378:metabolism*; D014714:Vertebrates / Q000235:genetics / Q000378:metabolism*
chemical_list: D012799:Sialyltransferases; D019158:N-Acetylneuraminic Acid
keywords: evolution; functional genomics; molecular phylogeny; sialic acid; sialyltransferases