title: Predisposing factors for poor prognosis of angiosarcoma of the scalp and face: Systematic review and meta-analysis.
abstract: Angiosarcoma of the scalp and face is an aggressive tumor with a high rate of local recurrence. Although many previous studies have demonstrated risk factors for poor prognosis, debate remains. We identified the predisposing factors for poor prognosis through comprehensive review of selected studies with meta-analysis.
  
  
  
  A systematic literature review and meta-analysis were performed using MEDLINE, EMBASE, and Cochrane databases. Nine variables were extracted from the included studies and evaluated based on a 5-year survival rate. The Newcastle-Ottawa scale was used to assess the quality of the studies.
  
  
  
  The search strategy identified 89 publications. After screening, 11 articles were selected for review. Age, size, site of tumor, margin status, and surgery associated with poor angiosarcoma prognosis were identified.
  
  
  
  Although further investigation of long-term and prospective studies is needed, we identified 5 variables as predisposing factors for poor prognosis of angiosarcoma through meta-analysis. © 2016 Wiley Periodicals, Inc. Head Neck 39: 380-386, 2017.
authors: Department of Plastic and Reconstructive Surgery, Medical School of Chonbuk National University, Jeonju, Korea.
authors: Jin Yong
authors: JY
authors: Shin
authors: Department of Plastic and Reconstructive Surgery, Medical School of Chonbuk National University, Jeonju, Korea.
authors: Si-Gyun
authors: SG
authors: Roh
authors: Department of Plastic and Reconstructive Surgery, Medical School of Chonbuk National University, Jeonju, Korea.
authors: Nae-Ho
authors: NH
authors: Lee
authors: Department of Plastic and Reconstructive Surgery, Medical School of Chonbuk National University, Jeonju, Korea.
authors: Kyung-Moo
authors: KM
authors: Yang
mesh_terms: D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D015984:Causality; D018572:Disease-Free Survival; D005153:Facial Neoplasms / Q000453:epidemiology* / Q000473:pathology / Q000628:therapy; D005260:Female; D006394:Hemangiosarcoma / Q000453:epidemiology* / Q000473:pathology / Q000628:therapy; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D018570:Risk Assessment; D012535:Scalp; D012737:Sex Factors; D012878:Skin Neoplasms / Q000453:epidemiology* / Q000473:pathology / Q000628:therapy; D016019:Survival Analysis
keywords: angiosarcoma; meta-analysis; poor prognosis; risk factor; systematic review