title: Seeing is Believing: Tracking Translation Dynamics In Vivo.
abstract: Translation is a crucial step in transmitting genetic information from mRNA to functional protein. Four recent papers provide novel imaging approaches to directly observe translation of single mRNAs in real time in live cells, and represent a powerful toolkit to dissect the molecular mechanisms of translation regulation.
authors: Division of Endocrinology and Metabolism, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, and Collaborative Innovation Center of Biotherapy, Chengdu 610041, Sichuan, China.
authors: Chunhua
authors: C
authors: Li
authors: Division of Endocrinology and Metabolism, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, and Collaborative Innovation Center of Biotherapy, Chengdu 610041, Sichuan, China.
authors: Yan
authors: Y
authors: Tian
authors: Division of Endocrinology and Metabolism, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, and Collaborative Innovation Center of Biotherapy, Chengdu 610041, Sichuan, China. Electronic address: xfu@scu.edu.cn.
authors: Xianghui
authors: X
authors: Fu
mesh_terms: D045744:Cell Line, Tumor; D005456:Fluorescent Dyes / Q000737:chemistry; D057809:HEK293 Cells; D006801:Humans; D007140:Immunoglobulin Fab Fragments / Q000737:chemistry; D057054:Molecular Imaging / Q000379:methods*; D014176:Protein Biosynthesis; D012333:RNA, Messenger / Q000235:genetics* / Q000378:metabolism; D012270:Ribosomes / Q000737:chemistry*; D013194:Staining and Labeling / Q000379:methods; D059008:Time-Lapse Imaging
chemical_list: D005456:Fluorescent Dyes; D007140:Immunoglobulin Fab Fragments; D012333:RNA, Messenger