title: Donor liver steatosis: A risk factor for early new-onset diabetes after liver transplantation.
abstract: OBJECTIVE
  To investigate whether donor liver steatosis increases the incidence of new-onset diabetes after transplantation (NODAT) in liver transplant recipients.
  
  
  METHODS
  We retrospectively analyzed liver transplant recipients at Zhongshan Hospital, Shanghai, China, from April 2001 to December 2014. The final analysis involved 763 patients. The cumulative incidence of NODAT at 1, 3, 5 and 10 years after liver transplantation was investigated. Furthermore, according to the findings of donor liver biopsy before transplantation, patients were divided into steatotic and non-steatotic donor liver groups, and NODAT incidence was compared between these groups. Multivariate Cox regression was used to explore the risk factors for NODAT in the patients.
  
  
  RESULTS
  Of the 763 donors, 309 (40.5%) had liver steatosis. At the end of follow up, 130 (42.1%) patients in the steatotic donor liver group developed NODAT, an incidence that exceeded that in the non-steatotic donor liver group (P = 0.001). The cumulative incidence of NODAT among all patients at 1, 3, 5, and 10 years after transplantation was 33, 43, 50 and 56%, respectively. The cumulative incidences of NODAT at 1, 3, 5 and 10 years in the steatotic donor liver group were significantly higher than those in the non-steatotic donor liver group (P = 0.003). Multivariate Cox regression analyses showed that donor liver steatosis was an independent risk factor for NODAT among liver transplant recipients, after other potential risk factors were adjusted for (hazard ratio 1.774, 95% confidence interval: 1.025-3.073; P = 0.041).
  
  
  CONCLUSIONS
  Donor liver steatosis increases NODAT incidence among liver transplant recipients.
authors: Department of Endocrinology and Metabolism, Zhongshan Hospital, Fudan University, Shanghai, China.
authors: Mengjuan
authors: M
authors: Xue
authors: Department of Endocrinology and Metabolism, Zhongshan Hospital, Fudan University, Shanghai, China.
authors: Chaoyang
authors: C
authors: Lv
authors: Department of Endocrinology and Metabolism, Zhongshan Hospital, Fudan University, Shanghai, China.|Department of Endocrinology and Metabolism, Hainan Provincial Nong Ken Hospital, Hainan, China.
authors: Xianying
authors: X
authors: Chen
authors: Department of Endocrinology and Metabolism, Zhongshan Hospital, Fudan University, Shanghai, China.
authors: Jing
authors: J
authors: Liang
authors: Department of Endocrinology and Metabolism, Zhongshan Hospital, Fudan University, Shanghai, China.
authors: Chenhe
authors: C
authors: Zhao
authors: Department of Endocrinology and Metabolism, Zhongshan Hospital, Fudan University, Shanghai, China.
authors: Yao
authors: Y
authors: Zhang
authors: Department of Liver Surgery, Zhongshan Hospital, Fudan University, China.
authors: Xiaowu
authors: X
authors: Huang
authors: Department of Liver Surgery, Zhongshan Hospital, Fudan University, China.
authors: Qiman
authors: Q
authors: Sun
authors: Department of Liver Surgery, Zhongshan Hospital, Fudan University, China.
authors: Ting
authors: T
authors: Wang
authors: Center of Clinical Epidemiology and Evidence-based Medicine, Fudan University, Shanghai, China.
authors: Jian
authors: J
authors: Gao
authors: Department of Liver Surgery, Zhongshan Hospital, Fudan University, China.
authors: Jian
authors: J
authors: Zhou
authors: Department of Endocrinology and Metabolism, Zhongshan Hospital, Fudan University, Shanghai, China.
authors: Mingxiang
authors: M
authors: Yu
authors: Department of Liver Surgery, Zhongshan Hospital, Fudan University, China.
authors: Jia
authors: J
authors: Fan
authors: Department of Endocrinology and Metabolism, Zhongshan Hospital, Fudan University, Shanghai, China.
authors: Xin
authors: X
authors: Gao
mesh_terms: D003920:Diabetes Mellitus / Q000453:epidemiology* / Q000209:etiology*; D005234:Fatty Liver / Q000150:complications*; D005260:Female; D006801:Humans; D016031:Liver Transplantation / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012307:Risk Factors
keywords: Donor liver steatosis; Liver transplantation; New-onset diabetes after transplantation