title: Total Synthesis of the Resorcyclic Acid Lactone Spiroketal Citreoviranol.
abstract: The first total synthesis of resorcyclic acid lactone spiroketal citreoviranol (1) is described. The synthesis was completed in nine steps and via Sonogashira cross-coupling, gold-catalyzed cyclization, and an unusual base-induced ketalization. The relative and absolute stereochemistry of citreoviranol was unambiguously confirmed using 2D NMR spectroscopy and X-ray crystallography.
authors: School of Chemical Sciences and Maurice Wilkins Centre for Molecular Biodiscovery, University of Auckland , 23 Symonds Street, Auckland 1142, New Zealand.
authors: Rachelle
authors: R
authors: Quach
authors: School of Chemical Sciences and Maurice Wilkins Centre for Molecular Biodiscovery, University of Auckland , 23 Symonds Street, Auckland 1142, New Zealand.
authors: Daniel P
authors: DP
authors: Furkert
authors: School of Chemical Sciences and Maurice Wilkins Centre for Molecular Biodiscovery, University of Auckland , 23 Symonds Street, Auckland 1142, New Zealand.
authors: Margaret A
authors: MA
authors: Brimble