title: Targeting bactoprenol-coupled cell envelope precursors.
abstract: Targeting the bactoprenol-coupled cell wall precursor lipid II is a validated antibacterial strategy. In this review, selected prototype lipid II-binding antibiotics of different chemical classes are discussed. Although these compounds attack the same molecular target, they trigger nuanced and diverse cellular effects. Consequently, the mechanisms of antibacterial resistance and the likelihood of resistance development may vary substantially.
authors: Pharmaceutical Microbiology, University of Bonn, Meckenheimer Allee 168, 53105, Bonn, Germany.
authors: Hannah
authors: H
authors: Ulm
authors: Pharmaceutical Microbiology, University of Bonn, Meckenheimer Allee 168, 53105, Bonn, Germany. tanja@microbiology-bonn.de.|German Centre for Infection Research (DZIF), Partner Site Bonn-Cologne, Bonn, Germany. tanja@microbiology-bonn.de.
authors: Tanja
authors: T
authors: Schneider
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects / Q000378:metabolism; D002473:Cell Wall / Q000187:drug effects* / Q000378:metabolism*; D024881:Drug Resistance, Bacterial; D013729:Terpenes / Q000037:antagonists & inhibitors* / Q000378:metabolism*; D014538:Uridine Diphosphate N-Acetylmuramic Acid / Q000031:analogs & derivatives* / Q000037:antagonists & inhibitors / Q000378:metabolism
chemical_list: D000900:Anti-Bacterial Agents; D013729:Terpenes; D014538:Uridine Diphosphate N-Acetylmuramic Acid; C069249:muramyl-NAc-(pentapeptide)pyrophosphoryl-undecaprenol; C000146:bactoprenol
keywords: Antibiotics; Bactoprenol-phosphate; Cell wall; Lipid II; Resistance