title: Low-dose interleukin-2 treatment selectively modulates CD4(+) T cell subsets in patients with systemic lupus erythematosus.
abstract: Systemic lupus erythematosus (SLE) is a potentially life-threatening autoimmune disease characterized by altered balance of activity between effector and regulatory CD4(+) T cells. The homeostasis of CD4(+) T cell subsets is regulated by interleukin (IL)-2, and reduced production of IL-2 by T cells is observed in individuals with SLE. Here we report that treatment with low-dose recombinant human IL-2 selectively modulated the abundance of regulatory T (Treg) cells, follicular helper T (TFH) cells and IL-17-producing helper T (TH17) cells, but not TH1 or TH2 cells, accompanied by marked reductions of disease activity in patients with SLE.
authors: Department of Rheumatology and Immunology, Peking University People's Hospital, Beijing, China.
authors: Jing
authors: J
authors: He
authors: Department of Rheumatology and Immunology, Peking University People's Hospital, Beijing, China.
authors: Xia
authors: X
authors: Zhang
authors: Laboratory of Immunology for Environment and Health, Shandong Analysis and Test Center, Shandong Academy of Sciences, Jinan, China.
authors: Yunbo
authors: Y
authors: Wei
authors: Department of Rheumatology and Immunology, Peking University People's Hospital, Beijing, China.
authors: Xiaolin
authors: X
authors: Sun
authors: Laboratory for Molecular Immunomodulation, Department of Biochemistry and Molecular Biology, Infection and Immunity Program, Monash Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia.
authors: Yaping
authors: 0000-0002-1940-0966
authors: Y
authors: Chen
authors: China-Australia Centre for Personalised Immunology, Shanghai Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
authors: Jun
authors: J
authors: Deng
authors: Department of Rheumatology and Immunology, Peking University People's Hospital, Beijing, China.
authors: Yuebo
authors: Y
authors: Jin
authors: Department of Rheumatology and Immunology, Peking University People's Hospital, Beijing, China.
authors: Yuzhou
authors: Y
authors: Gan
authors: Laboratory for Molecular Immunomodulation, Department of Biochemistry and Molecular Biology, Infection and Immunity Program, Monash Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia.
authors: Xin
authors: X
authors: Hu
authors: Department of Rheumatology and Immunology, Peking University People's Hospital, Beijing, China.
authors: Rulin
authors: R
authors: Jia
authors: Department of Rheumatology and Immunology, Peking University People's Hospital, Beijing, China.
authors: Chuanhui
authors: C
authors: Xu
authors: Laboratory of Immunology for Environment and Health, Shandong Analysis and Test Center, Shandong Academy of Sciences, Jinan, China.
authors: Zhaohua
authors: Z
authors: Hou
authors: Laboratory for Molecular Immunomodulation, Department of Biochemistry and Molecular Biology, Infection and Immunity Program, Monash Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia.
authors: Yew Ann
authors: YA
authors: Leong
authors: Department of Rheumatology and Immunology, Peking University People's Hospital, Beijing, China.
authors: Lei
authors: L
authors: Zhu
authors: Laboratory of Immunology for Environment and Health, Shandong Analysis and Test Center, Shandong Academy of Sciences, Jinan, China.
authors: Jinhong
authors: J
authors: Feng
authors: Department of Rheumatology and Immunology, Peking University People's Hospital, Beijing, China.
authors: Yuan
authors: Y
authors: An
authors: Department of Rheumatology and Immunology, Peking University People's Hospital, Beijing, China.
authors: Yuan
authors: Y
authors: Jia
authors: Department of Rheumatology and Immunology, Peking University People's Hospital, Beijing, China.
authors: Chun
authors: C
authors: Li
authors: Department of Rheumatology and Immunology, Peking University People's Hospital, Beijing, China.
authors: Xu
authors: X
authors: Liu
authors: Department of Rheumatology and Immunology, Peking University People's Hospital, Beijing, China.
authors: Hua
authors: H
authors: Ye
authors: Department of Rheumatology and Immunology, Peking University People's Hospital, Beijing, China.
authors: Limin
authors: L
authors: Ren
authors: Department of Rheumatology and Immunology, Peking University People's Hospital, Beijing, China.
authors: Ru
authors: R
authors: Li
authors: Department of Rheumatology and Immunology, Peking University People's Hospital, Beijing, China.
authors: Haihong
authors: H
authors: Yao
authors: Department of Rheumatology and Immunology, Peking University People's Hospital, Beijing, China.
authors: Yuhui
authors: Y
authors: Li
authors: Department of Rheumatology and Immunology, Peking University People's Hospital, Beijing, China.
authors: Shi
authors: S
authors: Chen
authors: Department of Rheumatology and Immunology, Peking University People's Hospital, Beijing, China.
authors: Xuewu
authors: X
authors: Zhang
authors: Department of Rheumatology and Immunology, Peking University People's Hospital, Beijing, China.
authors: Yin
authors: Y
authors: Su
authors: Department of Rheumatology and Immunology, Peking University People's Hospital, Beijing, China.
authors: Jianping
authors: J
authors: Guo
authors: China-Australia Centre for Personalised Immunology, Shanghai Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
authors: Nan
authors: N
authors: Shen
authors: Centre for Inflammatory Diseases, School of Clinical Sciences at Monash Health, Monash University, Clayton, Victoria, Australia.
authors: Eric F
authors: 0000-0002-9507-3338
authors: EF
authors: Morand
authors: Laboratory of Immunology for Environment and Health, Shandong Analysis and Test Center, Shandong Academy of Sciences, Jinan, China.|Laboratory for Molecular Immunomodulation, Department of Biochemistry and Molecular Biology, Infection and Immunity Program, Monash Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia.|China-Australia Centre for Personalised Immunology, Shanghai Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.|Centre for Inflammatory Diseases, School of Clinical Sciences at Monash Health, Monash University, Clayton, Victoria, Australia.
authors: Di
authors: 0000-0003-1721-8922
authors: D
authors: Yu
authors: Department of Rheumatology and Immunology, Peking University People's Hospital, Beijing, China.
authors: Zhanguo
authors: Z
authors: Li
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000818:Animals; D015496:CD4-Positive T-Lymphocytes / Q000187:drug effects / Q000276:immunology; D049109:Cell Proliferation / Q000187:drug effects; D004195:Disease Models, Animal; D005260:Female; D006801:Humans; D007376:Interleukin-2 / Q000008:administration & dosage* / Q000494:pharmacology / Q000627:therapeutic use; D008180:Lupus Erythematosus, Systemic / Q000188:drug therapy* / Q000276:immunology; D008297:Male; D051379:Mice; D008875:Middle Aged; D011446:Prospective Studies; D016176:T-Lymphocyte Subsets / Q000187:drug effects / Q000276:immunology; D006377:T-Lymphocytes, Helper-Inducer / Q000187:drug effects / Q000276:immunology*; D050378:T-Lymphocytes, Regulatory / Q000187:drug effects / Q000276:immunology*; D018417:Th1 Cells / Q000187:drug effects / Q000276:immunology; D058504:Th17 Cells / Q000187:drug effects / Q000276:immunology; D018418:Th2 Cells / Q000187:drug effects / Q000276:immunology; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D007376:Interleukin-2