title: Role of Genetic Testing in Patients with Ventricular Arrhythmias in Apparently Normal Hearts.
abstract: Ventricular arrhythmias without structural heart disease are responsible for ∼35% of patients who have sudden cardiac death before the age of 40 years. Molecular autopsy and/or cardiological investigation of nearby family members often reveals the diagnosis and genetic testing can be helpful in family screening and risk stratification in disease carriers. Extended gene panels can be screened in a short period of time at low cost. A multidisciplinary team of (genetically) specialized clinicians is necessary to judge all the available details and to decide on the significance of the variant and further strategies.
authors: Department of Clinical Genetics, Academic Medical Center, M0-229, Meibergdreef 9, Amsterdam 1105 AZ, The Netherlands.
authors: Nynke
authors: N
authors: Hofman
authors: Department of Cardiology, Academic Medical Center, B2-239, Meibergdreef 9, Amsterdam 1105 AZ, The Netherlands. Electronic address: a.a.wilde@amc.nl.
authors: Arthur A M
authors: AA
authors: Wilde
mesh_terms: D000328:Adult; D001145:Arrhythmias, Cardiac / Q000175:diagnosis / Q000235:genetics; D016757:Death, Sudden, Cardiac; D005260:Female; D005820:Genetic Testing; D006321:Heart / Q000502:physiology / Q000503:physiopathology; D006801:Humans; D008297:Male; D009154:Mutation
keywords: Brugada syndrome; CPVT; ERS; Genes; LQTS; SQTS; Sudden cardiac death; Ventricular arrhythmias