title: Analysis of Gait Disturbance in Glut 1 Deficiency Syndrome.
abstract: Anticipating potential therapies for Glut 1 deficiency syndrome (Glut1DS) emphasizes the need for effective clinical outcome measures. The 6-minute walk test is a well-established outcome measure that evaluates walking ability in neurological diseases. Twenty-one children with Glut 1 deficiency syndrome and 21 controls performed the 6-minute walk test. Fatigue was determined by comparing distance walked in the first and sixth minutes. Gait was analyzed by stride length, velocity, cadence, base of support, and percentage time in double support. Independent sample t-tests examined differences between group. Repeated-measures analysis of variance evaluated gait parameters over time. Glut 1 deficiency syndrome patients walked less (P < .05), had slower velocities (P < .0001), had shorter stride lengths (P < .0001), spent more time in double support (P < .001), and had increasing variability in base of support (P = .009). Glut 1 deficiency syndrome patients have impaired motor performance, walk more slowly, and have poor balance. The 6-minute walk test with gait analysis may serve as a useful outcome measure in clinical trials in Glut 1 deficiency syndrome.
authors: Department of Neurology, Columbia University Medical Center, New York, NY, USA.
authors: Michelle
authors: M
authors: Blumenschine
authors: Department of Neurology, Columbia University Medical Center, New York, NY, USA Department of Rehabilitation Medicine, Columbia University Medical Center, New York, NY, USA.
authors: Jacqueline
authors: J
authors: Montes
authors: Department of Rehabilitation Medicine, Columbia University Medical Center, New York, NY, USA.
authors: Ashwini K
authors: AK
authors: Rao
authors: Department of Neurology, Columbia University Medical Center, New York, NY, USA.
authors: Kristin
authors: K
authors: Engelstad
authors: Department of Neurology, Columbia University Medical Center, New York, NY, USA dcd1@columbia.edu.
authors: Darryl C
authors: DC
authors: De Vivo
mesh_terms: D000293:Adolescent; D001696:Biomechanical Phenomena; D002239:Carbohydrate Metabolism, Inborn Errors / Q000175:diagnosis* / Q000503:physiopathology*; D005080:Exercise Test; D005221:Fatigue / Q000175:diagnosis / Q000503:physiopathology; D005684:Gait / Q000502:physiology; D006801:Humans; D008297:Male; D009004:Monosaccharide Transport Proteins / Q000172:deficiency*; D012720:Severity of Illness Index; D011795:Surveys and Questionnaires; D055815:Young Adult
chemical_list: D009004:Monosaccharide Transport Proteins
keywords: 6-minute walk test; Glut 1 deficiency syndrome; gait analysis; outcome measure; weakness