title: TiO2microspheres containing magnetic nanoparticles for intra-arterial hyperthermia.
abstract: Magnetic microspheres measuring 15-35 µm in diameter are believed to be useful for intra-arterial hyperthermia. In this study, we attempted to prepare titanium dioxide (TiO2) microspheres containing magnetic nanoparticles (MNPs). MNP-containing TiO2microspheres with diameters of approximately 30 µm were successfully obtained by sol-gel reaction of titanium tetraisopropoxide in a water-in-oil emulsion with added cosurfactant of 1-butanol and subsequent heat treatment at 200°C. The microspheres showed ferrimagnetism owing to high content of MNPs in approximately 60 wt % and had a low-crystalline TiO2matrix. Furthermore, the agar phantom was heated to above 43°C after approximately 1 min under an alternating magnetic field of 100 kHz and 300 Oe and showed in vitro biocompatibility similar to that of MNP-free TiO2microspheres. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 105B: 2308-2314, 2017.
authors: Graduate School of Dentistry, Tohoku University, Sendai, 980-8575, Japan.
authors: Hiroyasu
authors: H
authors: Kanetaka
authors: Graduate School of Biomedical Engineering, Tohoku University, Sendai, 980-8579, Japan.
authors: Gengci
authors: G
authors: Liu
authors: School of Chemistry and Chemical Engineering, Guangxi University, Nanning, 530004, China.
authors: Zhixia
authors: Z
authors: Li
authors: Graduate School of Life Science and Systems Engineering, Kyushu Institute of Technology, Kitakyushu, 808-0196, Japan.
authors: Toshiki
authors: T
authors: Miyazaki
authors: Graduate School of Dentistry, Tohoku University, Sendai, 980-8575, Japan.
authors: Maiko
authors: M
authors: Furuya
authors: Graduate School of Dentistry, Tohoku University, Sendai, 980-8575, Japan.
authors: Tada-Aki
authors: TA
authors: Kudo
authors: Graduate School of Biomedical Engineering, Tohoku University, Sendai, 980-8579, Japan.
authors: Masakazu
authors: M
authors: Kawashita
mesh_terms: D000818:Animals; D002460:Cell Line; D006979:Hyperthermia, Induced / Q000379:methods*; D060526:Magnetic Fields; D058185:Magnetite Nanoparticles / Q000737:chemistry*; D051381:Rats; D014025:Titanium / Q000737:chemistry / Q000494:pharmacology
chemical_list: D058185:Magnetite Nanoparticles; C009495:titanium dioxide; D014025:Titanium
keywords: TiO2; hyperthermia; magnetic nanoparticles; microspheres