title: Downregulation of long non-coding RNA HCG11 predicts a poor prognosis in prostate cancer.
abstract: Long non-coding RNAs (lncRNA) have been reported as key regulators in the progression and metastasis of prostate cancer (PCa). In this study, we found that the expression levels of HCG11 in PCa tissues were significantly lower than those in non-tumor tissues in publically available databases and in human PCa samples. Our results showed the expression levels of HCG11 in patients with PCa were associated with the age, Lymph Node Status (LN status), preoperative PSA level, Gleason score, and biochemical recurrence (BCR). Kaplan-Meier analysis indicated that downregulation of HCG11 expression in tissues was associated with poor survival of PCa patients. GO and KEGG pathway analysis were applied to explore the potential roles of HCG11. Moreover, a HCG11 mediated ceRNA network was built using co-expression relationships of the differentially expressed mRNAs and miRNAs. We believed that this study will provide a potential new therapeutic and prognostic target for prostate cancer.
authors: State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Science, Fudan University, Shanghai, 200433, People's Republic of China.
authors: Yalong
authors: Y
authors: Zhang
authors: State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Science, Fudan University, Shanghai, 200433, People's Republic of China.
authors: Pu
authors: P
authors: Zhang
authors: State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Science, Fudan University, Shanghai, 200433, People's Republic of China.
authors: Xuechao
authors: X
authors: Wan
authors: State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Science, Fudan University, Shanghai, 200433, People's Republic of China.
authors: Xinya
authors: X
authors: Su
authors: State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Science, Fudan University, Shanghai, 200433, People's Republic of China.
authors: Zhe
authors: Z
authors: Kong
authors: Center of Translational Medicine, Central Hospital of Zibo, Zibo, 255036, People's Republic of China.
authors: Qiaoli
authors: Q
authors: Zhai
authors: Center of Translational Medicine, Central Hospital of Zibo, Zibo, 255036, People's Republic of China.
authors: Xinxin
authors: X
authors: Xiang
authors: Center of Translational Medicine, Central Hospital of Zibo, Zibo, 255036, People's Republic of China. Electronic address: liliangzb@sina.com.
authors: Liang
authors: L
authors: Li
authors: State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Science, Fudan University, Shanghai, 200433, People's Republic of China. Electronic address: yaoli@fudan.edu.cn.
authors: Yao
authors: Y
authors: Li
mesh_terms: D015536:Down-Regulation / Q000235:genetics*; D015972:Gene Expression Regulation, Neoplastic; D063990:Gene Ontology; D053263:Gene Regulatory Networks; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009364:Neoplasm Recurrence, Local / Q000473:pathology; D011379:Prognosis; D011471:Prostatic Neoplasms / Q000235:genetics* / Q000473:pathology; D062085:RNA, Long Noncoding / Q000235:genetics* / Q000378:metabolism; D015398:Signal Transduction / Q000235:genetics
chemical_list: D062085:RNA, Long Noncoding; C000613894:long noncoding RNA HCG11, human
keywords: Clinic pathologic features; HCG11; Prognosis; Prostate cancer; ceRNA