title: Effectiveness of add-on l-methylfolate therapy in a complex psychiatric illness with MTHFR C677 T genetic polymorphism.
abstract: The 5,10-methylenetetrahydrofolate reductase (MTHFR) gene plays a central role in folate metabolism. Many studies have demonstrated an association between MTHFR C677 T variant with depression, schizophrenia and bipolar disorder as one of them being comorbid to other. This has justified the use of folate supplement in psychiatric disorders mainly depression but still not in various other comorbid complex psychiatric disorders. Here we have tried to show how the l-methylfolate in conjunction with the conventional psychotropic drugs can be useful in a state of such complex psychiatric phenomenon and comorbid diagnosis with genetic polymorphism of MTHFR C677 T mutation.
authors: Institute of Human Behavior and Allied Sciences (IHBAS), Dilshad Garden, Delhi 110095, India. Electronic address: dr.shaileshk.jha@gmail.com.
authors: Shailesh
authors: S
authors: Jha
authors: Institute of Human Behavior and Allied Sciences (IHBAS), Dilshad Garden, Delhi 110095, India.
authors: Pankaj
authors: P
authors: Kumar
authors: Institute of Human Behavior and Allied Sciences (IHBAS), Dilshad Garden, Delhi 110095, India.
authors: Rajesh
authors: R
authors: Kumar
authors: Govind Ballabh Pant Institute of Postgraduate Medical Education & Research, Jawaharlal Nehru Marg, New Delhi, Delhi 110002, India.
authors: Aparna
authors: A
authors: Das
mesh_terms: D000328:Adult; D000928:Antidepressive Agents / Q000008:administration & dosage / Q000494:pharmacology*; D014150:Antipsychotic Agents / Q000008:administration & dosage / Q000494:pharmacology*; D000068180:Aripiprazole / Q000008:administration & dosage / Q000494:pharmacology; D001714:Bipolar Disorder / Q000188:drug therapy*; D061218:Depressive Disorder, Treatment-Resistant / Q000188:drug therapy*; D004359:Drug Therapy, Combination; D005473:Fluoxetine / Q000008:administration & dosage / Q000494:pharmacology; D006801:Humans; D018020:Lithium Compounds / Q000008:administration & dosage / Q000494:pharmacology; D008297:Male; D042965:Methylenetetrahydrofolate Reductase (NADPH2) / Q000235:genetics*; D009771:Obsessive-Compulsive Disorder / Q000188:drug therapy*; D011110:Polymorphism, Genetic; D013763:Tetrahydrofolates / Q000008:administration & dosage / Q000494:pharmacology*; D014803:Vitamin B Complex / Q000008:administration & dosage / Q000494:pharmacology*
chemical_list: D000928:Antidepressive Agents; D014150:Antipsychotic Agents; D018020:Lithium Compounds; D013763:Tetrahydrofolates; D005473:Fluoxetine; D014803:Vitamin B Complex; D000068180:Aripiprazole; C573423:MTHFR protein, human; D042965:Methylenetetrahydrofolate Reductase (NADPH2); C005984:5-methyltetrahydrofolate
keywords: MTHFR genetic polymorphism; Obsessive–compulsive disorder; Treatment resistant depression