title: "Click" Chemistry-Tethered Hyaluronic Acid-Based Contact Lens Coatings Improve Lens Wettability and Lower Protein Adsorption.
abstract: Improving the wettability of and reducing the protein adsorption to contact lenses may be beneficial for improving wearer comfort. Herein, we describe a simple "click" chemistry approach to surface functionalize poly(2-hydroxyethyl methacrylate) (pHEMA)-based contact lenses with hyaluronic acid (HA), a carbohydrate naturally contributing to the wettability of the native tear film. A two-step preparation technique consisting of laccase/TEMPO-mediated oxidation followed by covalent grafting of hydrazide-functionalized HA via simple immersion resulted in a model lens surface that is significantly more wettable, more water retentive, and less protein binding than unmodified pHEMA while maintaining the favorable transparency, refractive, and mechanical properties of a native lens. The dipping/coating method we developed to covalently tether the HA wetting agent is simple, readily scalable, and a highly efficient route for contact lens modification.
authors: Department of Chemical Engineering, McMaster University , Hamilton, Ontario L8S 4L7, Canada.
authors: Xudong
authors: X
authors: Deng
authors: Department of Chemical Engineering, McMaster University , Hamilton, Ontario L8S 4L7, Canada.
authors: Myrto
authors: M
authors: Korogiannaki
authors: Department of Chemical Engineering, McMaster University , Hamilton, Ontario L8S 4L7, Canada.|Department of Biology, Faculty of Sciences, Shiraz University , Shiraz, Fars 71946-84636, Iran.
authors: Banafsheh
authors: B
authors: Rastegari
authors: Department of Chemical Engineering, McMaster University , Hamilton, Ontario L8S 4L7, Canada.
authors: Jianfeng
authors: J
authors: Zhang
authors: School of Nursing, McMaster University , Hamilton, Ontario L8S 4L8, Canada.
authors: Mengsu
authors: M
authors: Chen
authors: Department of Chemical Engineering, McMaster University , Hamilton, Ontario L8S 4L7, Canada.
authors: Qiang
authors: Q
authors: Fu
authors: Department of Chemical Engineering, McMaster University , Hamilton, Ontario L8S 4L7, Canada.
authors: Heather
authors: H
authors: Sheardown
authors: Department of Chemical Engineering, McMaster University , Hamilton, Ontario L8S 4L7, Canada.
authors: Carlos D M
authors: CD
authors: Filipe
authors: Department of Chemical Engineering, McMaster University , Hamilton, Ontario L8S 4L7, Canada.
authors: Todd
authors: T
authors: Hoare
mesh_terms: D000327:Adsorption; D003261:Contact Lenses; D006820:Hyaluronic Acid / Q000737:chemistry*; D011506:Proteins; D017155:Wettability
chemical_list: D011506:Proteins; D006820:Hyaluronic Acid
keywords: TEMPO oxidation; hyaluronic acid; poly(2-hydroxyethyl methacrylate); protein adsorption; surface wettability