title: Herpes virus reactivation after initiation of interferon-free antiviral agents in HIV-HCV-coinfected subjects: a new immune restoration disease?
abstract: We report four HCV-HIV-coinfected patients who developed herpes zoster or muco-cutaneous herpes virus disease shortly after starting interferon-free antiviral treatment for HCV. We suggest that in our patients the prompt clearance of HCV following direct-acting antivirals leads to a paradoxical effect on the innate and adaptive immune system mediating the reactivation of herpetic infection.
authors: Infectious Diseases Unit, Department of Public Health and Infectious Diseases, Sapienza University, Polo Pontino, Latina, Italy.
authors: Raffaella
authors: R
authors: Marocco
authors: Infectious Diseases Unit, Department of Public Health and Infectious Diseases, Sapienza University, Polo Pontino, Latina, Italy.
authors: Miriam
authors: M
authors: Lichtner
authors: Infectious Diseases Unit, Department of Public Health and Infectious Diseases, Sapienza University, Polo Pontino, Latina, Italy.
authors: Tiziana
authors: T
authors: Tieghi
authors: Infectious Diseases Unit, Department of Public Health and Infectious Diseases, Sapienza University, Polo Pontino, Latina, Italy.
authors: Irene
authors: I
authors: Pozzetto
authors: Infectious Diseases Unit, Department of Public Health and Infectious Diseases, Sapienza University, Polo Pontino, Latina, Italy.
authors: Claudio M
authors: CM
authors: Mastroianni
mesh_terms: D000328:Adult; D000998:Antiviral Agents / Q000627:therapeutic use*; D060085:Coinfection / Q000188:drug therapy* / Q000276:immunology; D005260:Female; D015658:HIV Infections / Q000188:drug therapy* / Q000276:immunology / Q000821:virology; D019698:Hepatitis C, Chronic / Q000188:drug therapy* / Q000276:immunology / Q000821:virology; D014645:Herpesvirus 3, Human / Q000187:drug effects* / Q000502:physiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D018139:Simplexvirus / Q000187:drug effects* / Q000502:physiology; D014775:Virus Activation / Q000187:drug effects*
chemical_list: D000998:Antiviral Agents