title: The association of vitamin D with inflammatory cytokines in diabetic peripheral neuropathy.
abstract: [Purpose] The effects of vitamin D on the circulating levels of IL-17 and IL-13 were investigated in patients with diabetic peripheral neuropathy, patients with diabetes mellitus type 2 without neuropathy, and healthy controls. [Subjects and Methods] A single-blind controlled clinical study was performed, including70 type 2 diabetic patients with or without diabetic peripheral neuropathy and 33 healthy volunteer controls. The 25(OH)D levels were evaluated using ultra-performance liquid chromatography, and IL-17 and IL-13 levels were assessed using enzyme-linked immunosorbent assays. [Results] The 25(OH) vitamin D concentration was lower in diabetic peripheral neuropathy patients than in diabetes mellitus patients without neuropathy and healthy controls. Similarly, 25(OH)D levels were lower in diabetes mellitus patients than healthy controls. IL-17 and IL-13 levels were higher in diabetes mellitus patients than in controls. Additionally, IL-13 levels were higher in diabetic peripheral neuropathy patients than in diabetes mellitus patients without neuropathy. These differences were statistically significant. There was a significant positive correlation between 25(OH)D and IL-13,and a negative correlation between 25(OH)D andIL-17 in the diabetic and diabetic neuropathy groups. [Conclusion] Vitamin D is a potential modifiable risk factor for diabetic peripheral neuropathy and may regulate inflammatory mediators, e.g., IL-17 and IL-13.
authors: Department of Internal Medicine, Namik Kemal University School of Medicine, Turkey.
authors: Bulent
authors: B
authors: Bilir
authors: Department of Biochemistry, Namik Kemal University School of Medicine, Turkey.
authors: Feti
authors: F
authors: Tulubas
authors: Clinic of Endocrinology, Republic of Turkey Ministry of Health, State Hospital, Turkey.
authors: Betul Ekiz
authors: BE
authors: Bilir
authors: Clinic of Endocrinology, Republic of Turkey Ministry of Health, State Hospital, Turkey.
authors: Neslihan Soysal
authors: NS
authors: Atile
authors: Department of Internal Medicine, Namik Kemal University School of Medicine, Turkey.
authors: Sonat Pinar
authors: SP
authors: Kara
authors: Department of Physical Medicine and Rehabilitation, Namik Kemal University School of Medicine, Turkey.
authors: Tulay
authors: T
authors: Yildirim
authors: Department of Orthopaedic and Traumatology, Republic of Turkey Ministry of Health General Secretariat of the Public Hospitals Union, Turkey.
authors: Seyit Ali
authors: SA
authors: Gumustas
authors: Department of Biostatistics Tekirdag, Namik Kemal University School of Medicine, Turkey.
authors: Birol
authors: B
authors: Topcu
authors: Department of Biochemistry, Namik Kemal University School of Medicine, Turkey.
authors: Ozlem
authors: O
authors: Kaymaz
authors: Department of Biochemistry, Namik Kemal University School of Medicine, Turkey.
authors: Murat
authors: M
authors: Aydin
keywords: Cytokines; Diabetic peripheral neuropathy; Vitamin D