title: Effect of Opiate Receptors Blockade on Microbicidal Potential and Production of IL-1β, TNFα, and IL-10 by Peritoneal Macrophages under Stress Conditions.
abstract: Rotation stress activated spontaneous and zymosan-induced ROS production. In animals receiving naloxone against the background of rotation stress, ROS production did not increase. Immobilization stress did not change the intensity of spontaneous and zymosan-induced ROS production, but inhibited stimulated ROS production against the background of naloxone treatment. Rotation produced a naloxone-independent inhibitory effect on spontaneous and stimulated IL-1β and TNFα production by macrophages and naloxone-dependent stimulating effect on spontaneous IL-10 production. Rotation stress did not modulate stimulated IL-10 production. In case of immobilization stress, decreased IL-1β and TNFα production was observed in mice exposed to stress under conditions of opiate receptors blockade; IL-10 production was not affected by immobilization stress. Both types of stress significantly increased plasma corticosterone levels, while naloxone had no effect on corticosterone production.
authors: Institute of Ecology and Genetics of Microorganisms, the Ural Division of Russian Academy of Sciences, Perm, Russia. gein@iegm.ru.
authors: S V
authors: SV
authors: Gein
authors: Institute of Ecology and Genetics of Microorganisms, the Ural Division of Russian Academy of Sciences, Perm, Russia.
authors: I L
authors: IL
authors: Sharavieva
mesh_terms: D000818:Animals; D002478:Cells, Cultured; D003345:Corticosterone / Q000494:pharmacology; D016753:Interleukin-10 / Q000378:metabolism*; D053583:Interleukin-1beta / Q000378:metabolism*; D008264:Macrophages / Q000187:drug effects* / Q000378:metabolism*; D008297:Male; D051379:Mice; D009270:Naloxone / Q000494:pharmacology; D009292:Narcotic Antagonists / Q000494:pharmacology; D017382:Reactive Oxygen Species / Q000378:metabolism; D011957:Receptors, Opioid / Q000378:metabolism*; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism*; D015054:Zymosan / Q000494:pharmacology
chemical_list: D053583:Interleukin-1beta; D009292:Narcotic Antagonists; D017382:Reactive Oxygen Species; D011957:Receptors, Opioid; D014409:Tumor Necrosis Factor-alpha; D016753:Interleukin-10; D009270:Naloxone; D015054:Zymosan; D003345:Corticosterone
keywords: interleukin-1β and interleukin-10; macrophages; opiate receptors; stress; tumor necrosis factor α