title: Evaluation of pharmacological activity of Hibiscus tiliaceus.
abstract: Hibiscus tiliaceus, locally known as Bhola was examined for phytochemical properties and its cytotoxic, antibacterial, analgesic and neuropharmacological activities using the ethanol extract of leaf and bark. The phytochemical analysis of the leaf extract indicated the presence of tannins, whereas bark extract indicated the presence of alkaloid, reducing sugar and tannins. A preliminary cytotoxicity of these extracts was determined by a simple and low cost assay using brine shrimp lethality. The leaf extract of the plant exhibited moderate cytotoxic effect (LC50: 20 µg/ml, LC90: 40 µg/ml) whereas the bark extract exhibited low cytotoxic effect (LC50: 50 µg/ml). In the analgesic test, the leaf extract showed comparatively high analgesic action than bark extract. There was no activity found in the leaf extract against the test bacterial strains, however bark extract exhibited a very little inhibitory effect on Staphylococcus aureus and Staphylococcus epidermidis. In the neuropharmacological test, the leaf and bark extract produced a decrease in both the time of onset of sleeping and the total sleeping time. The present study showed evidence that both leaf and bark extract of H. tiliaceus contain medicinally important bioactive compounds, thereby used as traditional medicine.
authors: Biotechnology and Genetic Engineering Discipline, Khulna University, Khulna, 9208 Bangladesh.
authors: S M
authors: 0000-0002-6425-251X
authors: SM
authors: Abdul-Awal
authors: Biotechnology and Genetic Engineering Discipline, Khulna University, Khulna, 9208 Bangladesh.|Statistics Canada, 9700 Jasper Avenue (Canada Place), Edmonton, AB T5J4C3 Canada.
authors: Sonia
authors: S
authors: Nazmir
authors: Soil Science Discipline, Khulna University, Khulna, 9208 Bangladesh.
authors: Sonia
authors: S
authors: Nasrin
authors: Biotechnology and Genetic Engineering Discipline, Khulna University, Khulna, 9208 Bangladesh.
authors: Tauhidur Rahman
authors: TR
authors: Nurunnabi
authors: Pharmacy Discipline, Khulna University, Khulna, 9208 Bangladesh.
authors: Shaikh Jamal
authors: SJ
authors: Uddin
keywords: Analgesic; Antimicrobial; Bioactive; Cytotoxicity; Neuropharmacological