title: Deployment-Associated Exposure Surveillance With High-Resolution Metabolomics.
abstract: The aim of this study was to assess the suitability of high-resolution metabolomics (HRM) for measure of internal exposure and effect biomarkers from deployment-related environmental hazards.
  
  
  
  HRM provides extensive coverage of metabolism and data relevant to a broad spectrum of environmental exposures. This review briefly describes the analytic platform, workflow, and recent applications of HRM as a prototype environmental exposure surveillance system.
  
  
  
  Building upon techniques available for contemporary occupational medicine and exposure sciences, HRM methods are able to integrate external exposures, internal body burden of environmental agents, and relevant biological responses with health outcomes.
  
  
  
  Systematic analysis of existing Department of Defense Serum Repository samples will provide a high-quality, cross-sectional reference dataset for deployment-associated exposures while at the same time establishing a foundation for precision medicine.
authors: Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, Emory University, Atlanta, Georgia (Mr Walker, Drs Uppal, Go, Jones); Department of Civil and Environmental Engineering, Tufts University, Medford, Massachusetts (Mr Walker, Dr Pennell); Professor, Department of Preventive Medicine and Biostatistics, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD 20814 (Dr Mallon); Center for Air Resources Engineering and Science, Clarkson University, Potsdam, New York (Dr Hopke); and 779th Aerospace Medicine Squadron, 79th Medical Wing, Joint Base Andrews, MD (Dr Rohrbeck).
authors: Douglas I
authors: DI
authors: Walker
authors: Col Timothy M
authors: CT
authors: Mallon
authors: Philip K
authors: PK
authors: Hopke
authors: Karan
authors: K
authors: Uppal
authors: Young-Mi
authors: YM
authors: Go
authors: Patricia
authors: P
authors: Rohrbeck
authors: Kurt D
authors: KD
authors: Pennell
authors: Dean P
authors: DP
authors: Jones
mesh_terms: D015415:Biomarkers; D003430:Cross-Sectional Studies; D004781:Environmental Exposure / Q000032:analysis*; D004784:Environmental Monitoring; D006801:Humans; D055432:Metabolomics; D008889:Military Personnel; D016273:Occupational Exposure / Q000032:analysis*
chemical_list: D015415:Biomarkers