title: The aging effect on prostate metabolite concentrations measured by1H MR spectroscopy.
abstract: OBJECTIVE
  The effects of aging, magnetic field and the voxel localization on measured concentrations of citrate (Cit), creatine (Cr), cholines (Cho) and polyamines (PA) in a healthy prostate were evaluated.
  
  
  METHODS
  36 examinations at both 1.5T and 3T imagers of 52 healthy subjects aged 19-71 years were performed with PRESS 3D-CSI sequences (TE = 120 and 145 ms). Concentrations in laboratory units and their ratios to citrate were calculated using the LCModel technique. Absolute concentrations were also obtained after the application of correction coefficients. Statistical analysis was performed using a robust linear mixed effects model.
  
  
  RESULTS
  Significant effects of aging, the magnetic field strength and the voxel position in central (CZ) or peripheral (PZ) zones on all measured metabolites were found. The concentrations (mmol/kg wet tissue) including prediction intervals in a range of 20-70 years were found: Cit: 7.9-17.2; Cho: 1.4-1.7; Cr: 2.8-2.5; PA (as spermine): 0.6-2.1 at 3T in CZ. In PZ, the concentrations were higher by about 10 % as compared to CZ.
  
  
  CONCLUSIONS
  Increasing citrate and spermine concentrations with age are significant and correlate well with a recently described increase of zinc in the prostate. These findings should be considered in decision-making if the values obtained from a subject are in the range of control values.
authors: MR-Unit, Department of Diagnostic and Interventional Medicine, Institute for Clinical and Experimental Medicine, Videnska 1958/9, 14021, Prague 4, Czech Republic. mode@medicon.cz.
authors: Monika
authors: M
authors: Dezortova
authors: MR-Unit, Department of Diagnostic and Interventional Medicine, Institute for Clinical and Experimental Medicine, Videnska 1958/9, 14021, Prague 4, Czech Republic.
authors: Filip
authors: F
authors: Jiru
authors: MR-Unit, Department of Diagnostic and Interventional Medicine, Institute for Clinical and Experimental Medicine, Videnska 1958/9, 14021, Prague 4, Czech Republic.
authors: Antonin
authors: A
authors: Skoch
authors: MR-Unit, Department of Diagnostic and Interventional Medicine, Institute for Clinical and Experimental Medicine, Videnska 1958/9, 14021, Prague 4, Czech Republic.
authors: Vaclav
authors: V
authors: Capek
authors: MR-Unit, Department of Diagnostic and Interventional Medicine, Institute for Clinical and Experimental Medicine, Videnska 1958/9, 14021, Prague 4, Czech Republic.
authors: Zuzana
authors: Z
authors: Ryznarova
authors: Department of Urology, Thomayer Hospital, Videnska 800, 14000, Prague 4, Czech Republic.
authors: Viktor
authors: V
authors: Vik
authors: MR-Unit, Department of Diagnostic and Interventional Medicine, Institute for Clinical and Experimental Medicine, Videnska 1958/9, 14021, Prague 4, Czech Republic.
authors: Milan
authors: M
authors: Hajek
mesh_terms: D000328:Adult; D000368:Aged; D002794:Choline / Q000737:chemistry; D002951:Citrates / Q000737:chemistry; D003404:Creatinine / Q000737:chemistry; D003657:Decision Making; D006801:Humans; D060526:Magnetic Fields; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D008875:Middle Aged; D011073:Polyamines / Q000737:chemistry; D011467:Prostate / Q000000981:diagnostic imaging* / Q000378:metabolism; D011471:Prostatic Neoplasms / Q000000981:diagnostic imaging / Q000378:metabolism / Q000473:pathology; D013096:Spermine / Q000032:analysis; D055815:Young Adult; D015032:Zinc / Q000032:analysis
chemical_list: D002951:Citrates; D011073:Polyamines; D013096:Spermine; D003404:Creatinine; D015032:Zinc; D002794:Choline
keywords: 1H MRS; Aging; Choline; Citrate; Creatine; Polyamines; Prostate; Spermine