title: PGC-1α Mediated Peripheral Nerve Protection of Tongxinluo in STZ-Induced Diabetic Rats.
abstract: Aim. To investigate the effect of Tongxinluo (Txl), a Chinese herbal compound, on diabetic peripheral neuropathy (DPN). Methods and Results. Diabetic rat model was established by peritoneal injection of streptozotocin (STZ). Txl ultrafine powder treatment for 16 weeks from the baseline significantly reversed the impairment of motor nerve conductive velocity (MNCV), mechanical hyperalgesia, and nerve structure. We further proved that Tongxinluo upregulates PGC-1α and its downstream factors including COX IV and SOD, which were involved in mitochondrial biogenesis. Conclusion. Our study indicates that the protective effect of Txl in diabetic neuropathy may be attributed to the induction of PGC-1α and its downstream targets. This finding may further illustrate the pleiotropic effect of the medicine.
authors: Department of Geriatrics, Qilu Hospital of Shandong University, 107 Wenhuaxi Road, Jinan 250012, China.
authors: Xiaopei
authors: X
authors: Cui
authors: Digestive Disease Department, Shandong Provincial Hospital, Shandong University, Jinan, Shandong 250021, China.
authors: Hua
authors: H
authors: Feng
authors: Department of Geriatrics, Qilu Hospital of Shandong University, 107 Wenhuaxi Road, Jinan 250012, China.
authors: Xia
authors: X
authors: Xu
authors: Department of Geriatrics, Qilu Hospital of Shandong University, 107 Wenhuaxi Road, Jinan 250012, China.
authors: Haijun
authors: H
authors: Li
authors: Department of Geriatrics, Qilu Hospital of Shandong University, 107 Wenhuaxi Road, Jinan 250012, China.
authors: Hongyu
authors: 0000-0002-3254-0082
authors: H
authors: Zhang