title: Evaluation of brain perfusion in Alzheimer disease with perfusion computed tomography and comparison to elderly patient without dementia.
abstract: OBJECTIVE
  The aim of this study was to evaluate perfusion computed tomography (PCT) findings in patients with Alzheimer disease and to compare them with those of patients without dementia.
  
  
  METHODS
  PCT was performed in 35 patients: 20 with Alzheimer disease (mean age, 69.7 ± 5.5 years) and 15 control subjects (mean age, 67.5 ± 3.5 years). Control subjects were elderly individuals with no cognitive problems who were admitted with headaches. All PCT examinations were performed on a 4-slice CT unit. The PCT analysis software program was used to calculate regional cerebral blood flow (rCBF), regional cerebral blood volume (rCBV), regional time-to-peak (rTTP) values in the bilateral frontal, temporal, and occipital cortices, and bilateral lentiform nucleus.
  
  
  RESULTS
  rCBF values in the bilateral frontal and temporal cortices and bilateral lentiform nucleus were significantly lower in the patients with Alzheimer disease than in the control subjects. There were no significant differences in rCBV values between Alzheimer disease and the control group. rTTP values in all cortical areas and bilateral lentiform nucleus were significantly higher in the patients with Alzheimer disease than in the control subjects.
  
  
  CONCLUSIONS
  PCT is a rapid and reliable imaging modality for evaluating brain perfusion in Alzheimer disease.
authors: Department of Radiology, Faculty of Medicine, Başkent University, Ankara, Turkey.
authors: Tülin
authors: T
authors: Yildirim
authors: Department of Neurology, Başkent University Adana Medical and Teaching Research Center, Adana, Turkey.
authors: Başak
authors: B
authors: Karakurum Göksel
authors: Department of Radiology, Başkent University Adana Medical and Teaching Research Center, Adana, Turkey.
authors: Şenay
authors: Ş
authors: Demir
authors: Department of Radiology, Başkent University Adana Medical and Teaching Research Center, Adana, Turkey.
authors: Naime
authors: N
authors: Tokmak
authors: Department of Neurology, Başkent University Adana Medical and Teaching Research Center, Adana, Turkey.
authors: Meliha
authors: M
authors: Tan
mesh_terms: D000368:Aged; D000544:Alzheimer Disease; D001921:Brain; D002560:Cerebrovascular Circulation; D006801:Humans; D008875:Middle Aged; D015899:Tomography, Emission-Computed, Single-Photon; D014057:Tomography, X-Ray Computed
keywords: Alzheimer disease; brain perfusion; perfusion computed tomography