title: A comparative study of negative pressure wound therapy with and without instillation of saline on wound healing.
abstract: OBJECTIVE
  Negative pressure wound therapy (NPWT) has become an established treatment of traumatic and infected wounds. Negative pressure wound therapy with instillation (NPWTi) is a further development that combines the conventional NPWT with instillation of different fluids which continuously administer therapeutic reagents to the wound. The aim of this study was to compare the impact of additional saline instillation in NPWTi to NPWT alone.
  
  
  METHODS
  Between January and July 2014, consecutive patients with acute wounds of the lower limb were treated with NPWTi with saline instillation. The number of revision surgeries, length of hospital stay, and duration of treatment until final healing were recorded and compared with matched patients undergoing NPWT without instillation.
  
  
  RESULTS
  There were 10 patients recruited with 10 matched controls examined restrospectivley. Patients who received NPWTi were found to have decreased time of hospitalisation (21.5 versus 26.5 days, p=0.43), and accelerated wound healing (9.0 versus 12.5 days, p=0.36) than patients who received NPWT. However, the difference in the outcomes of the patients who received NPWTi and patients who received NPWT was not found to be statisticallly significant.
  
  
  CONCLUSIONS
  NPWTi with instillation of saline is a promising method and its effectiveness needs to be tested in a randomised controlled trial compared with NPWT alone.
  
  
  BACKGROUND
  This study obtained support by KCI (Wiebsaden, Germany) for the surgical material.
authors: Hannover Medical School, Trauma Department.
authors: M
authors: M
authors: Omar
authors: Hannover Medical School, Trauma Department.
authors: M
authors: M
authors: Gathen
authors: Hannover Medical School, Trauma Department.
authors: E
authors: E
authors: Liodakis
authors: Hannover Medical School, Trauma Department.
authors: E M
authors: EM
authors: Suero
authors: Hannover Medical School, Trauma Department.
authors: C
authors: C
authors: Krettek
authors: Hannover Medical School, Trauma Department.
authors: C
authors: C
authors: Zeckey
authors: Hannover Medical School, Trauma Department.
authors: M
authors: M
authors: Petri
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D005858:Germany; D006801:Humans; D008297:Male; D008875:Middle Aged; D054843:Negative-Pressure Wound Therapy / Q000379:methods*; D012965:Sodium Chloride / Q000627:therapeutic use*; D007507:Therapeutic Irrigation / Q000379:methods*; D014945:Wound Healing / Q000502:physiology*; D014946:Wound Infection / Q000188:drug therapy*; D014947:Wounds and Injuries / Q000628:therapy*
chemical_list: D012965:Sodium Chloride
keywords: NPWT; NPWTi; instillation; negative pressure wound therapy; wound healing