title: Acid-triggered release of doxorubicin from a hydrazone-linked Gd(3+)-texaphyrin conjugate.
abstract: The hydrazone-based Gd(3+)-texaphyrin doxorubicin conjugate 1, releases active doxorubicin at acidic pH values, allowing its components to be followed by two complementary imaging methods, namely Off-On fluorescence enhancement and MR imaging. It thus acts as a promising theranostic agent.
authors: Department of Chemistry, Sookmyung Women's University, Seoul 04310, Korea. minheelee@sookmyung.ac.kr.
authors: Min Hee
authors: MH
authors: Lee
authors: Bioimaging Research Team, Korea Basic Science Institute, Cheongju 28119, Korea. kshong@kbsi.re.kr.
authors: Eun-Joong
authors: EJ
authors: Kim
authors: Bioimaging Research Team, Korea Basic Science Institute, Cheongju 28119, Korea. kshong@kbsi.re.kr.
authors: Hyunseung
authors: H
authors: Lee
authors: Department of Chemistry, Sookmyung Women's University, Seoul 04310, Korea. minheelee@sookmyung.ac.kr.
authors: Sun Young
authors: SY
authors: Park
authors: Bioimaging Research Team, Korea Basic Science Institute, Cheongju 28119, Korea. kshong@kbsi.re.kr.
authors: Kwan Soo
authors: KS
authors: Hong
authors: Department of Chemistry, Korea University, Seoul 02841, Korea. jongskim@korea.ac.kr.
authors: Jong Seung
authors: JS
authors: Kim
authors: Department of Chemistry, University of Texas at Austin, Austin, TX 78712-1224, USA. sessler@cm.utexas.edu.
authors: Jonathan L
authors: JL
authors: Sessler
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*; D045744:Cell Line, Tumor; D002467:Cell Nucleus / Q000378:metabolism; D004317:Doxorubicin / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*; D005682:Gadolinium / Q000737:chemistry*; D006801:Humans; D006835:Hydrazones / Q000737:chemistry*; D006868:Hydrolysis; D008247:Lysosomes / Q000378:metabolism; D011166:Porphyrins / Q000737:chemistry / Q000378:metabolism*; D011355:Prodrugs / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*; D000068936:Theranostic Nanomedicine
chemical_list: D000970:Antineoplastic Agents; D006835:Hydrazones; D011166:Porphyrins; D011355:Prodrugs; C442892:texaphyrin; D004317:Doxorubicin; D005682:Gadolinium