title: Donation and Transplantation of Kidneys Harvested From Deceased Donors Over the Age of 60 Years in the Upper Silesia Region.
abstract: BACKGROUND
  Population aging and shortage of organs for transplantation result in increasing numbers of kidneys retrieved from elderly donors. The aim of this study was to analyze donation of kidneys from donors after brain death (DBD) over the age of 60 years (≥60), comorbidities that affect decisions on retrieval, and early results of kidney transplantation.
  
  
  METHODS
  Ninety-six potential DBD ≥60 and 309 aged 40-59 years (40-59) reported in Upper Silesia, Poland, from 2004 to 2013 were enrolled in the study.
  
  
  RESULTS
  DBD >60 presented a higher rate of coexisting hypertension (53% vs 34%), limb ischemia (10% vs 1%), and past stroke (6% vs 1%) compared with DBD 40-59 (P < .05), but no differences were observed in serum creatinine concentration (85 vs 84 μmol/L), coexisting coronary disease (14% vs 6%), or diabetes (10% vs 4%). The decision of withdrawal from retrieval was more frequent in DBD ≥60 (16% vs 7%; P < .05). Twelve months after kidney transplantation, serum creatinine concentration was higher in recipients of kidneys from DBD ≥60 compared with DBD 40-59 (169 vs 138 μmol/L; P < .001). The survivals of recipients (93% vs 95%) and kidney grafts (90% vs 93%) as well as rates of proteinuria >1.0 g/24 h (6% vs 2%) did not differ between the groups.
  
  
  CONCLUSIONS
  A higher rate of comorbidities in potential kidney DBD ≥60 results in a lower retrieval rate in these donors. The function of kidneys harvested from DBD ≥60 12 months after transplantation is worse than those from DBD 40-59, but still acceptable.
authors: Polish Transplant Coordinating Center "Poltransplant", Warsaw, Poland.
authors: S
authors: S
authors: Sekta
authors: Department of General, Vascular, and Transplant Surgery, Medical University of Silesia, Katowice, Poland. Electronic address: ziacek@mp.pl.
authors: J
authors: J
authors: Ziaja
authors: Department of Nephrology, Transplantation, and Internal Medicine, Medical University of Silesia, Katowice, Poland.
authors: A
authors: A
authors: Kolonko
authors: Department of Digestive Tract Surgery, Medical University of Silesia, Katowice, Poland.
authors: A
authors: A
authors: Lekstan
authors: Department of Transplantation Medicine and Nephrology, Medical University of Warsaw, Poland.
authors: R
authors: R
authors: Świder
authors: Department of General, Vascular, and Transplant Surgery, Medical University of Silesia, Katowice, Poland.
authors: J
authors: J
authors: Klimunt
authors: Chair of Anesthesiology, Intensive Therapy, and Emergency Medicine, Sosnowiec, Medical University of Silesia, Katowice, Poland.
authors: J
authors: J
authors: Wilk
authors: Department of General, Vascular, and Transplant Surgery, Medical University of Silesia, Katowice, Poland.
authors: R
authors: R
authors: Król
authors: Department of Transplantation Medicine and Nephrology, Medical University of Warsaw, Poland.
authors: M
authors: M
authors: Durlik
authors: Department of Nephrology, Transplantation, and Internal Medicine, Medical University of Silesia, Katowice, Poland.
authors: A
authors: A
authors: Więcek
authors: Department of General, Vascular, and Transplant Surgery, Medical University of Silesia, Katowice, Poland.
authors: L
authors: L
authors: Cierpka
mesh_terms: D000328:Adult; D000368:Aged; D001926:Brain Death; D005260:Female; D006085:Graft Survival; D006801:Humans; D016030:Kidney Transplantation / Q000379:methods*; D008297:Male; D008875:Middle Aged; D011044:Poland; D012189:Retrospective Studies; D014019:Tissue Donors / Q000600:supply & distribution*; D009927:Tissue and Organ Procurement / Q000379:methods; D016896:Treatment Outcome