title: Recurrent Syncope and Cardiac Arrest in a Patient with Systemic Light Chain Amyloidosis Treated with Bortezomib.
abstract: About 10-15% of patients with multiple myeloma develop light chain (AL) amyloidosis. AL amyloidosis is a systemic disease that may involve multiple organs, often including the heart. It may present clinically with bradyarrhythmia and syncope. The proteasome inhibitor bortezomib has been used with clinical efficacy in treating patients with AL amyloidosis but also implicated as a possible cause of cardiomyocyte injury. We report a case of a 48-year-old man with AL amyloidosis and increased frequency of syncope and cardiac arrest after starting bortezomib. The biologic and clinical plausibility of a heightened risk for cardiac arrest in patients with cardiac AL amyloidosis and history of syncope being treated with bortezomib is a possibility that is not well documented in the medical literature and warrants further investigation.
authors: VA Loma Linda Healthcare System, Loma Linda, CA, USA; Loma Linda University School of Medicine, Loma Linda, CA, USA.
authors: Navin
authors: N
authors: Jaipaul
authors: Loma Linda University School of Medicine , Loma Linda, CA, USA.
authors: Alexander
authors: A
authors: Pi
authors: VA Loma Linda Healthcare System, Loma Linda, CA, USA; Loma Linda University School of Medicine, Loma Linda, CA, USA.
authors: Zhiwei
authors: Z
authors: Zhang
keywords: Light chain amyloidosis; bortezomib; cardiac arrest; syncope