title: Adipocyte in vascular wall can induce the rupture of abdominal aortic aneurysm.
abstract: Abdominal aortic aneurysm (AAA) is a vascular disease involving the gradual dilation of the abdominal aorta. It has been reported that development of AAA is associated with inflammation of the vascular wall; however, the mechanism of AAA rupture is not fully understood. In this study, we investigated the mechanism underlying AAA rupture using a hypoperfusion-induced animal model. We found that the administration of triolein increased the AAA rupture rate in the animal model and that the number of adipocytes was increased in ruptured vascular walls compared to non-ruptured walls. In the ruptured group, macrophage infiltration and the protein levels of matrix metalloproteinases 2 and 9 were increased in the areas around adipocytes, while collagen-positive areas were decreased in the areas with adipocytes compared to those without adipocytes. The administration of fish oil, which suppresses adipocyte hypertrophy, decreased the number and size of adipocytes, as well as decreased the risk of AAA rupture ratio by 0.23 compared to the triolein administered group. In human AAA samples, the amount of triglyceride in the adventitia was correlated with the diameter of the AAA. These results suggest that AAA rupture is related to the abnormal appearance of adipocytes in the vascular wall.
authors: Department of Applied Biological Chemistry, Graduate School of Agriculture, Kindai University, 204-3327 Nakamachi, Nara City, Nara 631-8505, Japan.
authors: Hirona
authors: H
authors: Kugo
authors: Department of Applied Biological Chemistry, Graduate School of Agriculture, Kindai University, 204-3327 Nakamachi, Nara City, Nara 631-8505, Japan.
authors: Nobuhiro
authors: N
authors: Zaima
authors: Department of Medical Physiology, Hamamatsu University School of Medicine, Shizuoka, Japan.
authors: Hiroki
authors: H
authors: Tanaka
authors: Department of Applied Biological Chemistry, Graduate School of Agriculture, Kindai University, 204-3327 Nakamachi, Nara City, Nara 631-8505, Japan.
authors: Youhei
authors: Y
authors: Mouri
authors: Human Life Science R&D Center, Nippon Suisan Kaisha, Ltd., Tokyo, Japan.
authors: Kenichi
authors: K
authors: Yanagimoto
authors: Human Life Science R&D Center, Nippon Suisan Kaisha, Ltd., Tokyo, Japan.|General Health Medical Center, Yokohama University of Pharmacy, Japan.
authors: Kohsuke
authors: K
authors: Hayamizu
authors: Department of Applied Biological Chemistry, Graduate School of Agriculture, Kindai University, 204-3327 Nakamachi, Nara City, Nara 631-8505, Japan.
authors: Keisuke
authors: K
authors: Hashimoto
authors: Department of Anatomy and Neuroscience, Hamamatsu University School of Medicine, Japan.
authors: Takeshi
authors: T
authors: Sasaki
authors: Division of Vascular Surgery, Second Department of Surgery, Hamamatsu University School of Medicine, Japan.
authors: Masaki
authors: M
authors: Sano
authors: Division of Vascular Surgery, Second Department of Surgery, Hamamatsu University School of Medicine, Japan.
authors: Tatsuro
authors: T
authors: Yata
authors: Department of Medical Physiology, Hamamatsu University School of Medicine, Shizuoka, Japan.
authors: Tetsumei
authors: T
authors: Urano
authors: International Mass Imaging Center Department of Cellular and Molecular Anatomy, and Preeminent Medical Photonics Education &Research Center Department of Systems Molecular Anatomy, Hamamatsu University School of Medicine, 1-20-1 Handayama, Higashi-ku, Hamamatsu, Shizuoka 431-3192, Japan.|Department of Anatomy, The university of Hong Kong, 6/F, William MW Mong Block 21 Sassoon Road, Pokfulam, Hong Kong SAR, China.|Division of Neural Systematics, National Institute for Physiological Sciences, 38 Nishigonaka Myodaiji, Okazaki, Aichi, 444-8585, Japan.
authors: Mitsutoshi
authors: M
authors: Setou
authors: Division of Vascular Surgery, Second Department of Surgery, Hamamatsu University School of Medicine, Japan.
authors: Naoki
authors: N
authors: Unno
authors: Department of Applied Biological Chemistry, Graduate School of Agriculture, Kindai University, 204-3327 Nakamachi, Nara City, Nara 631-8505, Japan.
authors: Tatsuya
authors: T
authors: Moriyama
mesh_terms: D017667:Adipocytes / Q000166:cytology*; D000368:Aged; D000369:Aged, 80 and over; D000818:Animals; D017544:Aortic Aneurysm, Abdominal / Q000473:pathology* / Q000601:surgery; D003094:Collagen / Q000378:metabolism; D004730:Endothelium, Vascular / Q000166:cytology*; D005395:Fish Oils / Q000494:pharmacology; D006801:Humans; D006984:Hypertrophy; D008264:Macrophages / Q000166:cytology; D008297:Male; D020778:Matrix Metalloproteinase 2 / Q000378:metabolism; D020780:Matrix Metalloproteinase 9 / Q000378:metabolism; D008875:Middle Aged; D051381:Rats; D017207:Rats, Sprague-Dawley; D014304:Triolein / Q000008:administration & dosage
chemical_list: D005395:Fish Oils; D014304:Triolein; D003094:Collagen; C522361:MMP2 protein, human; D020778:Matrix Metalloproteinase 2; C522363:Mmp2 protein, rat; C579270:MMP9 protein, human; D020780:Matrix Metalloproteinase 9; C572337:Mmp9 protein, rat