title: Thrombotic Microangiopathy Care Pathway: A Consensus Statement for the Mayo Clinic Complement Alternative Pathway-Thrombotic Microangiopathy (CAP-TMA) Disease-Oriented Group.
abstract: Thrombotic microangiopathies (TMAs) comprise a heterogeneous set of conditions linked by a common histopathologic finding of endothelial damage resulting in microvascular thromboses and potentially serious complications. The typical clinical presentation is microangiopathic hemolytic anemia accompanied by thrombocytopenia with varying degrees of organ ischemia. The differential diagnoses are generally broad, while the workup is frequently complex and can be confusing. This statement represents the joint recommendations from a multidisciplinary team of Mayo Clinic physicians specializing in the management of TMA. It comprises a series of evidence- and consensus-based clinical pathways developed to allow a uniform approach to the spectrum of care including when to suspect TMA, what differential diagnoses to consider, which diagnostic tests to order, and how to provide initial empiric therapy, as well as some guidance on subsequent management.
authors: Division of Hematology, Mayo Clinic, Rochester, MN. Electronic address: go.ronald@mayo.edu.
authors: Ronald S
authors: RS
authors: Go
authors: Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN.
authors: Jeffrey L
authors: JL
authors: Winters
authors: Division of Nephrology and Hypertension, Mayo Clinic, Rochester, MN.
authors: Nelson
authors: N
authors: Leung
authors: Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN.
authors: David L
authors: DL
authors: Murray
authors: Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN.
authors: Maria A
authors: MA
authors: Willrich
authors: Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN.
authors: Roshini S
authors: RS
authors: Abraham
authors: Division of Nephrology and Hypertension, Mayo Clinic, Rochester, MN.
authors: Hatem
authors: H
authors: Amer
authors: Division of Hematology, Mayo Clinic, Rochester, MN.
authors: William J
authors: WJ
authors: Hogan
authors: Division of Hematology, Mayo Clinic, Rochester, MN.
authors: Ariela L
authors: AL
authors: Marshall
authors: Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN.
authors: Sanjeev
authors: S
authors: Sethi
authors: Division of Pediatric Nephrology, Mayo Clinic, Rochester, MN.
authors: Cheryl L
authors: CL
authors: Tran
authors: Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN.
authors: Dong
authors: D
authors: Chen
authors: Division of Hematology, Mayo Clinic, Rochester, MN.
authors: Rajiv K
authors: RK
authors: Pruthi
authors: Division of Hematology, Mayo Clinic, Rochester, MN.
authors: Aneel A
authors: AA
authors: Ashrani
authors: Division of Nephrology and Hypertension, Mayo Clinic, Rochester, MN.
authors: Fernando C
authors: FC
authors: Fervenza
authors: Division of Pediatric Nephrology, Mayo Clinic, Rochester, MN.
authors: Carl H
authors: CH
authors: Cramer
authors: Division of Pediatric Hematology-Oncology, Mayo Clinic, Rochester, MN.
authors: Vilmarie
authors: V
authors: Rodriguez
authors: Division of Hematology, Mayo Clinic, Rochester, MN.
authors: Alexandra P
authors: AP
authors: Wolanskyj
authors: Division of Community Oncology, Mayo Clinic, Rochester, MN.
authors: Stephan D
authors: SD
authors: Thomé
authors: Division of Hematology, Mayo Clinic, Rochester, MN. Electronic address: hook.christopher@mayo.edu.
authors: C Christopher
authors: CC
authors: Hook
mesh_terms: D000046:Academic Medical Centers; D000529:Complementary Therapies / Q000592:standards*; D032921:Consensus; D019317:Evidence-Based Medicine / Q000592:standards*; D006801:Humans; D008910:Minnesota; D017410:Practice Guidelines as Topic / Q000592:standards*; D057049:Thrombotic Microangiopathies / Q000628:therapy*