title: Structural Diversity and Biological Activities of Indole Diketopiperazine Alkaloids from Fungi.
abstract: Indole diketopiperazine alkaloids are secondary metabolites of microorganisms that are widely distributed in filamentous fungi, especially in the genera Aspergillus and Penicillium of the phylum Ascomycota or sac fungi. These alkaloids represent a group of natural products characterized by diversity in both chemical structures and biological activities. This review aims to summarize 166 indole diketopiperazine alkaloids from fungi published from 1944 to mid-2015. The emphasis is on diverse chemical structures within these alkaloids and their relevant biological activities. The aim is to assess which of these compounds merit further study for purposes of drug development.
authors.affiliation: Key Laboratory of Auxiliary Chemistry & Technology for Chemical Industry, Ministry of Education, Shaanxi University of Science & Technology , Xi'an 710021, Shaanxi, China.
authors.forename: Yang-Min
authors.initials: YM
authors.lastname: Ma
authors.affiliation: Key Laboratory of Auxiliary Chemistry & Technology for Chemical Industry, Ministry of Education, Shaanxi University of Science & Technology , Xi'an 710021, Shaanxi, China.
authors.forename: Xi-Ai
authors.initials: XA
authors.lastname: Liang
authors.affiliation: Key Laboratory of Auxiliary Chemistry & Technology for Chemical Industry, Ministry of Education, Shaanxi University of Science & Technology , Xi'an 710021, Shaanxi, China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Kong
authors.affiliation: Key Laboratory of Auxiliary Chemistry & Technology for Chemical Industry, Ministry of Education, Shaanxi University of Science & Technology , Xi'an 710021, Shaanxi, China.
authors.forename: Bin
authors.initials: B
authors.lastname: Jia
mesh_terms: D000818:Animals; D054659:Diketopiperazines / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology*; D005658:Fungi / Q000737:chemistry* / Q000378:metabolism; D006801:Humans; D026121:Indole Alkaloids / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology*
chemical_list: D054659:Diketopiperazines; D026121:Indole Alkaloids
keywords: biological activity; fungi; indole diketopiperazine alkaloids; natural product; structural diversity