title: Clinical and Virological Characteristics of Ebola Virus Disease Patients Treated With Favipiravir (T-705)-Sierra Leone, 2014.
abstract: BACKGROUND
  During 2014-2015, an outbreak of Ebola virus disease (EVD) swept across parts of West Africa. No approved antiviral drugs are available for Ebola treatment currently.
  
  
  METHODS
  A retrospective clinical case series was performed for EVD patients in Sierra Leone-China Friendship Hospital. Patients with confirmed EVD were sequentially enrolled and treated with either World Health Organization (WHO)-recommended supportive therapy (control group) from 10 to 30 October, or treated with WHO-recommended therapy plus favipiravir (T-705) from 1 to 10 November 2014. Survival and virological characteristics were observed for 85 patients in the control group and 39 in the T-705 treatment group.
  
  
  RESULTS
  The overall survival rate in the T-705 treatment group was higher than that of the control group (56.4% [22/39] vs 35.3% [30/85]; P = .027). Among the 35 patients who finished all designed endpoint observations, the survival rate in the T-705 treatment group (64.8% [11/17]) was higher than that of the control group (27.8% [5/18]). Furthermore, the average survival time of the treatment group (46.9 ± 5.6 days) was longer than that of the control group (28.9 ± 4.7 days). Most symptoms of patients in the treatment group improved significantly. Additionally, 52.9% of patients who received T-705 had a >100-fold viral load reduction, compared with only 16.7% of patients in the control group.
  
  
  CONCLUSIONS
  Treatment of EVD with T-705 was associated with prolonged survival and markedly reduced viral load, which makes a compelling case for further randomized controlled trials of T-705 for treating EVD.
authors.affiliation: No. 307 Hospital.
authors.forename: Chang-Qing
authors.initials: CQ
authors.lastname: Bai
authors.affiliation: No. 302 Hospital, Beijing, China.
authors.forename: Jin-Song
authors.initials: JS
authors.lastname: Mu
authors.affiliation: Sierra Leone Ministry of Health and Sanitation, Freetown.
authors.forename: David
authors.initials: D
authors.lastname: Kargbo
authors.affiliation: Beijing Institute of Microbiology and Epidemiology, Beijing, China.
authors.forename: Ya-Bin
authors.initials: YB
authors.lastname: Song
authors.affiliation: No. 307 Hospital.
authors.forename: Wen-Kai
authors.initials: WK
authors.lastname: Niu
authors.affiliation: No. 302 Hospital, Beijing, China.
authors.forename: Wei-Min
authors.initials: WM
authors.lastname: Nie
authors.affiliation: Sierra Leone-China Friendship Hospital.
authors.forename: Alex
authors.initials: A
authors.lastname: Kanu
authors.affiliation: No. 307 Hospital.
authors.forename: Wei-Wei
authors.initials: WW
authors.lastname: Liu
authors.affiliation: Kingharman Road Hospital, Freetown, Sierra Leone.
authors.forename: Yao-Ping
authors.initials: YP
authors.lastname: Wang
authors.affiliation: Sierra Leone Ministry of Health and Sanitation, Freetown.
authors.forename: Foday
authors.initials: F
authors.lastname: Dafae
authors.affiliation: No. 302 Hospital, Beijing, China.
authors.forename: Tao
authors.initials: T
authors.lastname: Yan
authors.affiliation: Beijing Institute of Microbiology and Epidemiology, Beijing, China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Hu
authors.affiliation: Beijing Institute of Microbiology and Epidemiology, Beijing, China.
authors.forename: Yong-Qiang
authors.initials: YQ
authors.lastname: Deng
authors.affiliation: Key Laboratory of Jilin Province for Zoonosis Prevention and Control, Changchun.
authors.forename: Hui-Jun
authors.initials: HJ
authors.lastname: Lu
authors.affiliation: Chinese Academy of Medical Sciences and Peking Union Medical College.
authors.forename: Fan
authors.initials: F
authors.lastname: Yang
authors.affiliation: Institute for Viral Disease Control and Prevention.
authors.forename: Xiao-Guang
authors.initials: XG
authors.lastname: Zhang
authors.affiliation: Key Laboratory of Jilin Province for Zoonosis Prevention and Control, Changchun.
authors.forename: Yang
authors.initials: Y
authors.lastname: Sun
authors.affiliation: Institute for Viral Disease Control and Prevention.
authors.forename: Yu-Xi
authors.initials: YX
authors.lastname: Cao
authors.affiliation: Chinese Academy of Medical Sciences and Peking Union Medical College.
authors.forename: Hao-Xiang
authors.initials: HX
authors.lastname: Su
authors.affiliation: Kingharman Road Hospital, Freetown, Sierra Leone.
authors.forename: Yu
authors.initials: Y
authors.lastname: Sun
authors.affiliation: Key Laboratory of Jilin Province for Zoonosis Prevention and Control, Changchun.
authors.forename: Wen-Sen
authors.initials: WS
authors.lastname: Liu
authors.affiliation: Key Laboratory of Jilin Province for Zoonosis Prevention and Control, Changchun.
authors.forename: Cheng-Yu
authors.initials: CY
authors.lastname: Wang
authors.affiliation: Key Laboratory of Jilin Province for Zoonosis Prevention and Control, Changchun.
authors.forename: Jun
authors.initials: J
authors.lastname: Qian
authors.affiliation: No. 307 Hospital.
authors.forename: Liu
authors.initials: L
authors.lastname: Liu
authors.affiliation: Beijing Institute of Microbiology and Epidemiology, Beijing, China.
authors.forename: Hong
authors.initials: H
authors.lastname: Wang
authors.affiliation: Beijing Institute of Microbiology and Epidemiology, Beijing, China.
authors.forename: Yi-Gang
authors.initials: YG
authors.lastname: Tong
authors.affiliation: No. 307 Hospital.
authors.forename: Ze-Yuan
authors.initials: ZY
authors.lastname: Liu
authors.affiliation: No. 307 Hospital.
authors.forename: Yun-Song
authors.initials: YS
authors.lastname: Chen
authors.affiliation: Beijing Institute of Microbiology and Epidemiology, Beijing, China.
authors.forename: Hong-Quan
authors.initials: HQ
authors.lastname: Wang
authors.affiliation: Sierra Leone Ministry of Health and Sanitation, Freetown.
authors.forename: Brima
authors.initials: B
authors.lastname: Kargbo
authors.affiliation: Chinese Center for Disease Control and Prevention, Beijing, China.
authors.forename: George F
authors.initials: GF
authors.lastname: Gao
authors.affiliation: Beijing Institute of Microbiology and Epidemiology, Beijing, China.
authors.forename: Jia-Fu
authors.initials: JF
authors.lastname: Jiang
mesh_terms: D000293:Adolescent; D000328:Adult; D000577:Amides / Q000627:therapeutic use*; D000998:Antiviral Agents / Q000627:therapeutic use*; D029043:Ebolavirus; D005260:Female; D019142:Hemorrhagic Fever, Ebola / Q000188:drug therapy* / Q000453:epidemiology / Q000401:mortality* / Q000821:virology; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D011719:Pyrazines / Q000627:therapeutic use*; D012189:Retrospective Studies; D012807:Sierra Leone / Q000453:epidemiology; D019562:Viral Load; D055815:Young Adult
chemical_list: D000577:Amides; D000998:Antiviral Agents; D011719:Pyrazines; C462182:favipiravir
keywords: Ebola virus disease; Sierra Leone; clinical features; favipiravir; treatment