title: Smoking Cessation Can Reduce the Incidence of Postoperative Hypoxemia After On-Pump Coronary Artery Bypass Grafting Surgery.
abstract: OBJECTIVE
  To determine whether smoking cessation can reduce the incidence of postoperative hypoxemia (POH) after on-pump coronary artery bypass grafting (CABG) surgery.
  
  
  METHODS
  Prospective, single-center, observational study.
  
  
  METHODS
  Single-center university teaching hospital.
  
  
  METHODS
  The study comprised 300 patients undergoing on-pump CABG surgery who met the inclusion criteria. Patients were divided into the following 3 groups according to smoking status: sustained quitters (n = 132)-smoking cessation for more than 1 month and less than 1 year; quitters (n = 95)-smoking cessation for more than 1 week and less than 1 month; and smokers (n = 73)-smoking at least 1 cigarette per day for at least 1 year.
  
  
  METHODS
  None.
  
  
  RESULTS
  The primary outcome was the incidence of POH after on-pump CABG surgery. Secondary outcomes included length of postoperative mechanical ventilation and intensive care unit stay between the POH group and non-POH group. There were significant decreases of POH incidence in the sustained quitters and quitters compared with the smokers both after intensive care unit (ICU) admission and 24 hours after surgery (18.2%, 18.9%, v 32.9%; p = 0.036 and 9.8%, 10.5%, v 26%; p = 0.003, respectively), and there was no significant difference in POH incidence between the sustained quitters and quitters. The length of postoperative mechanical ventilation was longer in smokers than in sustained quitters and quitters (15.9±6.1 h v 11.9±5.3 h and 13.0±5.8 h, respectively; p<0.05), but there were no significant differences in the length of ICU stay among the 3 groups (54.2±7.5 h v 55.1±7.5 h and 53.7±6.6 h, respectively; p = 0.333).
  
  
  CONCLUSIONS
  Smoking cessation can reduce POH after on-pump CABG surgery, and it also can shorten the length of postoperative mechanical ventilation.
authors.affiliation: Departments of *Anesthesiology and. Electronic address: guanzheng1980@126.com.
authors.forename: Zheng
authors.initials: Z
authors.lastname: Guan
authors.affiliation: Hepatobiliary Surgery, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Lv
authors.affiliation: Department of Neurology, Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.
authors.forename: Jingjie
authors.initials: J
authors.lastname: Liu
authors.affiliation: Departments of *Anesthesiology and.
authors.forename: Lin
authors.initials: L
authors.lastname: Liu
authors.affiliation: Departments of *Anesthesiology and.
authors.forename: Hui
authors.initials: H
authors.lastname: Yuan
authors.affiliation: Departments of *Anesthesiology and.
authors.forename: Xin
authors.initials: X
authors.lastname: Shen
mesh_terms: D001026:Coronary Artery Bypass; D005260:Female; D006801:Humans; D000860:Hypoxia / Q000517:prevention & control*; D015994:Incidence; D007902:Length of Stay / Q000706:statistics & numerical data; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000517:prevention & control*; D011446:Prospective Studies; D016540:Smoking Cessation / Q000706:statistics & numerical data*
keywords: coronary artery bypass grafting; postoperative hypoxemia; smoking cessation