title: Mean Platelet Volume as a Potential Predictor of Cholesteatoma in Children.
abstract: OBJECTIVE
  Cholesteatoma is a chronic inflammatory clinical disorder, and it may cause hearing loss and various complications due to its destructive nature. Mean platelet volume (MPV) is a prothrombotic and proinflammatory marker. The aim of this study is to investigate predictive values of MPV, neutrophil-to-lymphocyte ratio, erythrocyte distribution width, and platelet lymphocyte ratio in cholesteatomatous or noncholesteatomatous pediatric chronic otitis media.
  
  
  METHODS
  In this study, the authors retrospectively analyzed 24 patients with cholesteatomatous chronic otitis media, 9 patients with noncholesteatomatous chronic otitis media, and 36 age- and sex-matched healthy controls. Cholesteatomatous and noncholesteatomatous chronic otitis media groups were compared with each other, and with controls for WBC, MPV, erythrocyte distribution width, neutrophil-to-lymphocyte ratio, and platelet lymphocyte ratio.
  
  
  RESULTS
  Mean platelet volume was significantly lower in patients with cholesteatoma (8.17 ± 1.22 fL) compared with the control group (10.42 ± 0.87 fL) (P <0.001). Region of conversion curve analysis showed that the cutoff level of 9.5 fL for MPV was an independent predictor for cholesteatoma with a high sensitivity (86%) and specificity (84%). Cholesteatomatous and noncholesteatomous chronic otitis media patients were similar for other parameters studied.
  
  
  CONCLUSIONS
  Mean platelet volume may be used as a fast-to-obtain, reliable, and inexpensive marker with a high predictive level to indicate cholesteatoma in children.
authors.affiliation: *Otorhinolaryngology Department, Meram Medical Faculty, Necmettin Erbakan Univerisity, Konya †Otorhinolaryngology Department, Mugla Sitki Kocman University, School of Medicine, Mugla, Turkey.
authors.forename: Mehmet Akif
authors.initials: MA
authors.lastname: Eryilmaz
authors.forename: Serhan
authors.initials: S
authors.lastname: Derin
mesh_terms: D000293:Adolescent; D015415:Biomarkers / Q000097:blood; D002648:Child; D002781:Cholesteatoma / Q000097:blood / Q000175:diagnosis*; D018424:Cholesteatoma, Middle Ear / Q000097:blood / Q000175:diagnosis*; D005260:Female; D006801:Humans; D008297:Male; D063847:Mean Platelet Volume / Q000379:methods*; D011237:Predictive Value of Tests; D012189:Retrospective Studies
chemical_list: D015415:Biomarkers