title: Membrane curvature in cell biology: An integration of molecular mechanisms.
abstract: Curving biological membranes establishes the complex architecture of the cell and mediates membrane traffic to control flux through subcellular compartments. Common molecular mechanisms for bending membranes are evident in different cell biological contexts across eukaryotic phyla. These mechanisms can be intrinsic to the membrane bilayer (either the lipid or protein components) or can be brought about by extrinsic factors, including the cytoskeleton. Here, we review examples of membrane curvature generation in animals, fungi, and plants. We showcase the molecular mechanisms involved and how they collaborate and go on to highlight contexts of curvature that are exciting areas of future research. Lessons from how membranes are bent in yeast and mammals give hints as to the molecular mechanisms we expect to see used by plants and protists.
authors.affiliation: Wellcome Trust/Cancer Research UK Gurdon Institute, University of Cambridge, Cambridge CB2 1QN, England, UK.
authors.forename: Iris K
authors.identifier: 0000-0003-3218-1742
authors.initials: IK
authors.lastname: Jarsch
authors.affiliation: Wellcome Trust/Cancer Research UK Gurdon Institute, University of Cambridge, Cambridge CB2 1QN, England, UK.
authors.forename: Frederic
authors.initials: F
authors.lastname: Daste
authors.affiliation: Wellcome Trust/Cancer Research UK Gurdon Institute, University of Cambridge, Cambridge CB2 1QN, England, UK j.gallop@gurdon.cam.ac.uk.
authors.forename: Jennifer L
authors.identifier: 0000-0002-9978-1382
authors.initials: JL
authors.lastname: Gallop
mesh_terms: D000818:Animals; D001696:Biomechanical Phenomena; D002462:Cell Membrane / Q000378:metabolism*; D048430:Cell Shape; D011992:Endosomes / Q000378:metabolism; D006801:Humans; D008954:Models, Biological; D055571:Secretory Pathway