title: Case Report of Sweet's Syndrome Associated With Autoimmune Hepatitis.
abstract: Autoimmune hepatitis is a subtle diagnosis that has many diverse clinical presentations. It has been reported in the literature to occur concomitantly with pyoderma gangrenosum, a neutrophilic dermatosis. Sweet's syndrome is another neutrophilic dermatosis and has been reported to be associated with autoimmune hepatitis in only 2 previous cases: 1 idiopathic and 1 drug induced. Here we report a third case in a 24-year-old woman diagnosed with Sweet's syndrome in association with autoimmune hepatitis, documenting a possible trend between neutrophilic dermatoses and autoimmune hepatitis. The patient presented with a history of fever and tender, erythematous plaques on her legs. Skin biopsy of a plaque confirmed histiocytoid Sweet's syndrome. Initial laboratory investigations revealed elevated transaminases, and liver biopsy confirmed autoimmune hepatitis. This case suggests autoimmune hepatitis should be considered as an association when investigating a patient with Sweet's syndrome.
authors.affiliation: 1 Division of Dermatology, Department of Medicine, University of Calgary, Calgary, AB, Canada.
authors.forename: Allison K
authors.initials: AK
authors.lastname: Cinats
authors.affiliation: 1 Division of Dermatology, Department of Medicine, University of Calgary, Calgary, AB, Canada.
authors.forename: Richard M
authors.initials: RM
authors.lastname: Haber
mesh_terms: D005260:Female; D019693:Hepatitis, Autoimmune / Q000097:blood / Q000150:complications* / Q000473:pathology; D006801:Humans; D016463:Sweet Syndrome / Q000150:complications* / Q000473:pathology; D055815:Young Adult
keywords: Sweet’s syndrome; autoimmune hepatitis; neutrophilic dermatosis