title: Variability in Cancer Risk and Outcomes Within US Latinos by National Origin and Genetic Ancestry.
abstract: Latinos have lower rates for most common cancer sites and higher rates of some less common cancers (gallbladder, liver, gastric, and cervical) than other ethnic/racial groups. Latinos are a highly heterogeneous population with diverse national origins, unique genetic admixture patterns, and wide spectrum of socio-demographic characteristics. Across the major cancers (breast, colorectal, prostate, lung, and liver) US-born Latinos have higher incidence and worse survival than foreign-born, and those with low-socioeconomic status have the lowest incidence. Puerto Rican and Cuban Latinos have higher incidence rates than Mexican Latinos. We have identified the following themes as understudied and critical to reduce the cancer burden among US Latinos: (1) etiological studies considering key sources of heterogeneity, (2) culturally sensitive cancer prevention strategies, (3) description of the molecular tumor landscape to guide treatments and improve outcomes, and (4) development of prediction models of disease risk and outcomes accounting for heterogeneity of Latinos.
authors.affiliation: Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA USA.|Department of Urology, Keck School of Medicine, University of Southern California, Los Angeles, CA USA.|Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA USA.
authors.forename: Mariana C
authors.initials: MC
authors.lastname: Stern
authors.affiliation: Department of Medicine, Division of General Internal Medicine, University of California San Francisco, San Francisco, CA USA.
authors.forename: Laura
authors.initials: L
authors.lastname: Fejerman
authors.affiliation: National Institute on Minority Health and Health Disparities, National Institutes of Health, Bethesda, MD USA.
authors.forename: Rina
authors.initials: R
authors.lastname: Das
authors.affiliation: Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA USA.|Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA USA.
authors.forename: V Wendy
authors.initials: VW
authors.lastname: Setiawan
authors.affiliation: Department of Medicine and Biochemistry, University of Puerto Rico Medical Sciences Campus and University of Puerto Rico Comprehensive Cancer Center, San Juan, Puerto Rico.
authors.forename: Marcia R
authors.initials: MR
authors.lastname: Cruz-Correa
authors.affiliation: National Institute on Minority Health and Health Disparities, National Institutes of Health, Bethesda, MD USA.
authors.forename: Eliseo J
authors.initials: EJ
authors.lastname: Perez-Stable
authors.affiliation: Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA USA.|Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA USA.
authors.forename: Jane C
authors.initials: JC
authors.lastname: Figueiredo
keywords: Cancer; Hispanic; Latino