title: Acronychiabaueri Analogue Derivative-Loaded Ultradeformable Vesicles: Physicochemical Characterization and Potential Applications.
abstract: Elastic and ultradeformable liposomes were synthesized and physicochemically characterized to make suitable topical formulations for delivering the anti-inflammatory and anticancer compound 3-(4'-geranyloxy-3'-methoxyphenyl)-2-trans-propenoic acid. The average sizes of elastic and ultradeformable liposomes are below 300 nm, while the size distribution and Z-potential are below 0.3 and - 25 mV, respectively. The presence of 3-(4'-geranyloxy-3'-methoxyphenyl)-2-trans-propenoic acid does not affect the physicochemical parameters of nanovesicles. Elastic and ultradeformable liposomes show a zero order release kinetic and are stable at room temperature for a long time with or without 3-(4'-geranyloxy-3'-methoxyphenyl)-2-trans-propenoic acid. The ultradeformable liposomes are more deformable than elastic liposomes. These differences may depend on sodium cholate derivatives making nanoformulations. The 3-(4'-geranyloxy-3'-methoxyphenyl)-2-trans-propenoic acid-loaded elastic and ultradeformable liposomes can provide innovative nanotherapeutics-based natural compounds for the potential treatment of cutanous inflammation.
authors.affiliation: Department of Health Sciences, University of Catanzaro "Magna Graecia", Catanzaro, Italy.
authors.forename: Martina
authors.initials: M
authors.lastname: Di Francesco
authors.affiliation: Department of Pharmacy, University of Chieti - Pescara "G. d'Annunzio", Chieti, Italy.
authors.forename: Rosita
authors.initials: R
authors.lastname: Primavera
authors.affiliation: Department of Pharmacy, University of Chieti - Pescara "G. d'Annunzio", Chieti, Italy.
authors.forename: Serena
authors.initials: S
authors.lastname: Fiorito
authors.affiliation: Department of Health Sciences, University of Catanzaro "Magna Graecia", Catanzaro, Italy.
authors.forename: Maria Chiara
authors.initials: MC
authors.lastname: Cristiano
authors.affiliation: Department of Pharmacy, University of Chieti - Pescara "G. d'Annunzio", Chieti, Italy.
authors.forename: Vito Alessandro
authors.initials: VA
authors.lastname: Taddeo
authors.affiliation: Department of Pharmacy, University of Chieti - Pescara "G. d'Annunzio", Chieti, Italy.
authors.forename: Francesco
authors.initials: F
authors.lastname: Epifano
authors.affiliation: Department of Pharmacy, University of Chieti - Pescara "G. d'Annunzio", Chieti, Italy.
authors.forename: Luisa
authors.initials: L
authors.lastname: Di Marzio
authors.affiliation: Department of Pharmacy, University of Chieti - Pescara "G. d'Annunzio", Chieti, Italy.
authors.forename: Salvatore
authors.initials: S
authors.lastname: Genovese
authors.affiliation: Department of Pharmacy, University of Chieti - Pescara "G. d'Annunzio", Chieti, Italy.
authors.forename: Christian
authors.initials: C
authors.lastname: Celia
mesh_terms: D000287:Administration, Topical; D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000494:pharmacology; D004224:Diterpenes / Q000008:administration & dosage* / Q000494:pharmacology; D016503:Drug Delivery Systems; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage* / Q000493:pharmacokinetics; D008081:Liposomes; D011422:Propionates / Q000008:administration & dosage* / Q000494:pharmacology; D027821:Rutaceae / Q000737:chemistry*
chemical_list: C506371:3-(4'-geranyloxy-3'-methoxyphenyl)-2-trans-propenoic acid; D000970:Antineoplastic Agents; D004224:Diterpenes; D004365:Drugs, Chinese Herbal; D008081:Liposomes; D011422:Propionates