title: Magnetization Transfer MRI Contrast May Correlate with Tissue Redox State in Prostate Cancer.
abstract: Developing imaging biomarkers for non-invasive measurement of the tissue redox state is a key research area. Recently, we presented the first non-invasive MR imaging method that demonstrated the correlation between the endogenous chemical exchange saturation transfer (CEST) contrast and the tissue redox state. It is well known that the broadband magnetization transfer (MT) can occur via chemical exchange (CEST) and/or dipole-dipole interactions. The present study investigated if the broadband MT also correlated with the tissue redox state. The preliminary result for the prostate tumor xenografts indeed showed a significant correlation between the broadband MT contrast and the NADH redox ratio quantified with the optical redox scanning. In vivo MT contrast, once calibrated, may potentially serve as an imaging biomarker for tissue redox state.
authors.affiliation: Department of Radiology, Center for MR Research, University of Illinois at Chicago, 2242 w. Harrison st., Chicago, IL, 60612, USA.
authors.forename: Rongwen
authors.initials: R
authors.lastname: Tain
authors.affiliation: Britton Chance Laboratory of Redox Imaging, Johnson Research Foundation; Department of Radiology, University of Pennsylvania, Philadelphia, PA, 19104, USA.
authors.forename: He N
authors.initials: HN
authors.lastname: Xu
authors.affiliation: Department of Radiology, Center for MR Research, University of Illinois at Chicago, 2242 w. Harrison st., Chicago, IL, 60612, USA.
authors.forename: Xiaohong J
authors.initials: XJ
authors.lastname: Zhou
authors.affiliation: Molecular Imaging Laboratory, Department of Radiology, Britton Chance Laboratory of Redox Imaging, Johnson Research Foundation, Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
authors.forename: Lin Z
authors.initials: LZ
authors.lastname: Li
authors.affiliation: Department of Radiology, Center for MR Research, University of Illinois at Chicago, 2242 w. Harrison st., Chicago, IL, 60612, USA. kcai@uic.edu.
authors.forename: Kejia
authors.initials: K
authors.lastname: Cai
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D003287:Contrast Media; D064593:Heterografts; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008819:Mice, Nude; D009243:NAD / Q000378:metabolism; D009368:Neoplasm Transplantation; D009389:Neovascularization, Pathologic; D010084:Oxidation-Reduction; D010100:Oxygen / Q000378:metabolism*; D011471:Prostatic Neoplasms / Q000098:blood supply / Q000000981:diagnostic imaging* / Q000378:metabolism / Q000473:pathology; D013997:Time Factors; D000072258:Tumor Hypoxia
chemical_list: D003287:Contrast Media; D009243:NAD; D010100:Oxygen
keywords: CEST; MRI; Magnetization transfer; Oxidative stress; Prostate cancer; Redox state