title: Satb2 Stations Neurons along Reflex Arcs.
abstract: The nociceptive flexor withdrawal reflex has an august place in the history of neuroscience. In this issue of Neuron, Hilde et al. (2016) advance our understanding of this reflex by characterizing the molecular identity and circuit connectivity of component interneurons. They assess how a DNA-binding factor Satb2 controls cell position, molecular identity, pre-and postsynaptic targeting, and function of a population of inhibitory sensory relay interneurons that serve to integrate both proprioceptive and nociceptive afferent information.
authors.affiliation: Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA 20147, USA.
authors.forename: Adam W
authors.initials: AW
authors.lastname: Hantman
authors.affiliation: Developmental Biology Program, Sloan Kettering Institute, New York, NY 10065, USA; Neuroscience Program and Cell and Developmental Biology Program, Weill Cornell Graduate School of Medical Science, Weill Cornell Medicine, New York, NY 10065, USA. Electronic address: kaltschj@mskcc.org.
authors.forename: Julia A
authors.initials: JA
authors.lastname: Kaltschmidt
mesh_terms: D007395:Interneurons; D009046:Motor Neurons; D009474:Neurons; D009475:Neurons, Afferent; D012018:Reflex