title: A General Catalytic Asymmetric Prins Cyclization.
abstract: A new class of highly acidic confined imino-imidodiphosphate (iIDP) Brønsted acids catalyze the asymmetric Prins cyclization of both aliphatic and aromatic aldehydes. Diverse functionalized 4-methylenetetrahydropyrans are obtained in good to excellent yields and with good to excellent regio- and enantioselectivities. Our iIDP catalysts provide an efficient and scalable enantioselective approach to various fragrances, including rose oxide and doremox.
authors.affiliation: Max-Planck-Institut für Kohlenforschung , Kaiser Wilhelm-Platz 1, 45470 Mülheim an der Ruhr, Germany.
authors.forename: Luping
authors.initials: L
authors.lastname: Liu
authors.affiliation: Max-Planck-Institut für Kohlenforschung , Kaiser Wilhelm-Platz 1, 45470 Mülheim an der Ruhr, Germany.
authors.forename: Philip S J
authors.initials: PS
authors.lastname: Kaib
authors.affiliation: Max-Planck-Institut für Kohlenforschung , Kaiser Wilhelm-Platz 1, 45470 Mülheim an der Ruhr, Germany.
authors.forename: Aurélien
authors.initials: A
authors.lastname: Tap
authors.affiliation: Max-Planck-Institut für Kohlenforschung , Kaiser Wilhelm-Platz 1, 45470 Mülheim an der Ruhr, Germany.
authors.forename: Benjamin
authors.initials: B
authors.lastname: List