title: Neuropsychological Profile of "Cognitive Frailty" Subjects in MAPT Study.
abstract: OBJECTIVE
  An international group proposed the existence of "cognitive frailty", a condition defined by simultaneous presence of physical frailty and cognitive impairment in the absence of dementia. The objective was to compare the neuropsychological profiles in subgroups of elders differentiated across their physical frailty (Fried phenotype) and cognitive status (Clinical Dementia Rating score) to characterize the "cognitive frailty" entity.
  
  
  METHODS
  We studied baseline characteristics of 1,617 subjects enrolled in Multidomain Alzheimer Disease Preventive Trial (MAPT). Included subjects were aged 70 years or older and presented at least 1 of the 3 following clinical criteria: (1) Memory complaint spontaneously reported to a general practitioner, (2) limitation in one instrumental activity of daily living, (3) slow gait speed. Subjects with dementia were not included in the trial.
  
  
  RESULTS
  "Cognitive frailty individuals" significantly differed from "individuals with cognitive impairment and without physical frailty", scoring worse at executive, and attention tests. They presented subcortico-frontal cognitive pattern different of Alzheimer Disease. Cognitive performance of subjects with 3 criteria or more of the frailty phenotype are cognitively more impaired than subjects with only one.
  
  
  CONCLUSIONS
  The characterization of "cognitive frailty" must be done in frail subjects to set up specific preventive clinical trials for this population.
authors.affiliation: Gérontopôle, Alzheimer's Disease Research and Clinical Center, Toulouse University Hospital, Toulouse, France; INSERM U 1027, Toulouse, France.
authors.forename: J
authors.initials: J
authors.lastname: Delrieu
authors.affiliation: INSERM U 1027, Toulouse, France.
authors.forename: S
authors.initials: S
authors.lastname: Andrieu
authors.affiliation: Department of Aging and Geriatric Research, University of Florida-Institute on Aging, Gainesville, FL, USA.
authors.forename: M
authors.initials: M
authors.lastname: Pahor
authors.affiliation: INSERM U 1027, Toulouse, France.
authors.forename: C
authors.initials: C
authors.lastname: Cantet
authors.affiliation: Gérontopôle, Alzheimer's Disease Research and Clinical Center, Toulouse University Hospital, Toulouse, France; INSERM U 1027, Toulouse, France.
authors.forename: M
authors.initials: M
authors.lastname: Cesari
authors.affiliation: Gérontopôle, Alzheimer's Disease Research and Clinical Center, Toulouse University Hospital, Toulouse, France; INSERM U 1027, Toulouse, France.
authors.forename: P J
authors.initials: PJ
authors.lastname: Ousset
authors.affiliation: Gérontopôle, Alzheimer's Disease Research and Clinical Center, Toulouse University Hospital, Toulouse, France; INSERM U 1027, Toulouse, France.
authors.forename: T
authors.initials: T
authors.lastname: Voisin
authors.affiliation: Gérontopôle, Alzheimer's Disease Research and Clinical Center, Toulouse University Hospital, Toulouse, France.
authors.forename: B
authors.initials: B
authors.lastname: Fougère
authors.affiliation: Gérontopôle, Alzheimer's Disease Research and Clinical Center, Toulouse University Hospital, Toulouse, France; INSERM U 1027, Toulouse, France.
authors.forename: S
authors.initials: S
authors.lastname: Gillette
authors.affiliation: Gérontopôle, Alzheimer's Disease Research and Clinical Center, Toulouse University Hospital, Toulouse, France.
authors.forename: I
authors.initials: I
authors.lastname: Carrie
authors.affiliation: Gérontopôle, Alzheimer's Disease Research and Clinical Center, Toulouse University Hospital, Toulouse, France; INSERM U 1027, Toulouse, France.
authors.forename: B
authors.initials: B
authors.lastname: Vellas
keywords: Alzheimer Disease; MAPT trial; cognitive frailty; elderly; physical frailty