title: Evaluating a novel treatment for coronary artery inflammation in acute Kawasaki disease: A Phase I/IIa trial of atorvastatin.
abstract: BACKGROUND
  Since the 1980s, the primary treatment of acute Kawasaki disease (KD) has been intravenous immunoglobulin and aspirin. However, 5-10% of children with acute KD will develop coronary artery abnormalities despite treatment within the first ten days after fever onset. There is no approved adjunctive therapy to prevent progression of coronary artery damage in these patients.
  
  
  METHODS
  The rationale and study design of a Phase I/IIa trial of atorvastatin in children with acute KD and coronary artery inflammation is presented. The studies of host genetics and KD pathogenesis leading up to this trial are reviewed.
  
  
  CONCLUSIONS
  The repurposing of well-studied drugs used in the adult population is a cost-effective and efficient strategy to identify new therapies for pediatric diseases. Exploiting the anti-inflammatory, non-lipid-lowering effects of statins may open up new applications for this class of drugs for the pediatric age group.
authors.affiliation: Kawasaki Disease Research Center, Department of Pediatrics, University of California San Diego, La Jolla, California, USA; Rady Children's Hospital San Diego, San Diego, California, USA.
authors.forename: Adriana H
authors.initials: AH
authors.lastname: Tremoulet
authors.affiliation: Biostatistics Research Center, Department of Family Medicine and Public Health, University of California San Diego, La Jolla, California.
authors.forename: Sonia
authors.initials: S
authors.lastname: Jain
authors.affiliation: Kawasaki Disease Research Center, Department of Pediatrics, University of California San Diego, La Jolla, California, USA; Rady Children's Hospital San Diego, San Diego, California, USA.
authors.forename: Jane C
authors.initials: JC
authors.lastname: Burns
keywords: Kawasaki disease; atorvastatin; intravenous immunoglobulin; repurposing