title: Cell Environment-Differentiated Self-Assembly of Nanofibers.
abstract: Employing cellular environment for the self-assembly of supramolecular nanofibers for biological applications has been widely explored. But using one precursor to differentiate the extra- and intracellular environments to self-assemble into two different nanofibers remains challenging. With the knowledge that the extracellualr environment of some cancer cells contains large amounts of alkaline phosphatase (ALP) while their intracellular environment is glutathione (GSH)-abundant in mind, we rationally designed a precursor Cys(SEt)-Glu-Tyr(H2PO3)-Phe-Phe-Gly-CBT (1) that can efficiently yield amphiphilic 2 and 2-D to self-assemble into two different nanofibers in hydrogels under the sequential treatment of ALP and GSH. We envision that, by employing a click condensation reaction, this work offers a platform for facilely postmodulation of supramolecular nanofibers, and the versatile precursor 1 could be used to kill two birds with one stone.
authors.affiliation: CAS Key Laboratory of Soft Matter Chemistry, †Department of Chemistry and ⊥Department of Polymer Science and Engineering and ‡Hefei National Laboratory for Physical Sciences at the Microscale, Department of Chemical Physics, University of Science and Technology of China , 96 Jinzhai Road, Hefei, Anhui 230026, China.
authors.forename: Zhen
authors.initials: Z
authors.lastname: Zheng
authors.affiliation: CAS Key Laboratory of Soft Matter Chemistry, †Department of Chemistry and ⊥Department of Polymer Science and Engineering and ‡Hefei National Laboratory for Physical Sciences at the Microscale, Department of Chemical Physics, University of Science and Technology of China , 96 Jinzhai Road, Hefei, Anhui 230026, China.
authors.forename: Peiyao
authors.initials: P
authors.lastname: Chen
authors.affiliation: CAS Key Laboratory of Soft Matter Chemistry, †Department of Chemistry and ⊥Department of Polymer Science and Engineering and ‡Hefei National Laboratory for Physical Sciences at the Microscale, Department of Chemical Physics, University of Science and Technology of China , 96 Jinzhai Road, Hefei, Anhui 230026, China.
authors.forename: Maolin
authors.initials: M
authors.lastname: Xie
authors.affiliation: CAS Key Laboratory of Soft Matter Chemistry, †Department of Chemistry and ⊥Department of Polymer Science and Engineering and ‡Hefei National Laboratory for Physical Sciences at the Microscale, Department of Chemical Physics, University of Science and Technology of China , 96 Jinzhai Road, Hefei, Anhui 230026, China.
authors.forename: Chengfan
authors.initials: C
authors.lastname: Wu
authors.affiliation: CAS Key Laboratory of Soft Matter Chemistry, †Department of Chemistry and ⊥Department of Polymer Science and Engineering and ‡Hefei National Laboratory for Physical Sciences at the Microscale, Department of Chemical Physics, University of Science and Technology of China , 96 Jinzhai Road, Hefei, Anhui 230026, China.
authors.forename: Yufeng
authors.initials: Y
authors.lastname: Luo
authors.affiliation: CAS Key Laboratory of Soft Matter Chemistry, †Department of Chemistry and ⊥Department of Polymer Science and Engineering and ‡Hefei National Laboratory for Physical Sciences at the Microscale, Department of Chemical Physics, University of Science and Technology of China , 96 Jinzhai Road, Hefei, Anhui 230026, China.
authors.forename: Wentao
authors.initials: W
authors.lastname: Wang
authors.affiliation: CAS Key Laboratory of Soft Matter Chemistry, †Department of Chemistry and ⊥Department of Polymer Science and Engineering and ‡Hefei National Laboratory for Physical Sciences at the Microscale, Department of Chemical Physics, University of Science and Technology of China , 96 Jinzhai Road, Hefei, Anhui 230026, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Jiang
authors.affiliation: CAS Key Laboratory of Soft Matter Chemistry, †Department of Chemistry and ⊥Department of Polymer Science and Engineering and ‡Hefei National Laboratory for Physical Sciences at the Microscale, Department of Chemical Physics, University of Science and Technology of China , 96 Jinzhai Road, Hefei, Anhui 230026, China.
authors.forename: Gaolin
authors.initials: G
authors.lastname: Liang
mesh_terms: D000469:Alkaline Phosphatase / Q000378:metabolism; D000595:Amino Acid Sequence; D045744:Cell Line, Tumor; D005110:Extracellular Space / Q000378:metabolism; D006801:Humans; D020100:Hydrogels / Q000737:chemistry; D057927:Hydrophobic and Hydrophilic Interactions; D008958:Models, Molecular; D057139:Nanofibers; D009842:Oligopeptides / Q000737:chemistry* / Q000378:metabolism*; D011487:Protein Conformation
chemical_list: D020100:Hydrogels; D009842:Oligopeptides; D000469:Alkaline Phosphatase