title: Modulation of Host miRNAs by Intracellular Bacterial Pathogens.
abstract: MicroRNAs (miRNAs) are short non-coding RNAs that regulate the expression of protein coding genes of viruses and eukaryotes at the post-transcriptional level. The eukaryotic genes regulated by miRNAs include those whose products are critical for biological processes such as cell proliferation, metabolic pathways, immune response, and development. It is now increasingly recognized that modulation of miRNAs associated with biological processes is one of the strategies adopted by bacterial pathogens to survive inside host cells. In this review, we present an overview of the recent findings on alterations of miRNAs in the host cells by facultative intracellular bacterial pathogens. In addition, we discuss how the altered miRNAs help in the survival of these pathogens in the intracellular environment.
authors.affiliation: Center of Emphasis in Infectious Diseases and Department of Biomedical Sciences, Paul L. Foster School of Medicine, Texas Tech University Health Sciences Center El Paso El Paso, TX, USA.
authors.forename: Kishore
authors.initials: K
authors.lastname: Das
authors.affiliation: Center of Emphasis in Infectious Diseases and Department of Biomedical Sciences, Paul L. Foster School of Medicine, Texas Tech University Health Sciences Center El Paso El Paso, TX, USA.
authors.forename: Omar
authors.initials: O
authors.lastname: Garnica
authors.affiliation: Center of Emphasis in Infectious Diseases and Department of Biomedical Sciences, Paul L. Foster School of Medicine, Texas Tech University Health Sciences Center El Paso El Paso, TX, USA.
authors.forename: Subramanian
authors.initials: S
authors.lastname: Dhandayuthapani
mesh_terms: D000818:Animals; D001419:Bacteria / Q000276:immunology / Q000378:metabolism* / Q000472:pathogenicity; D001424:Bacterial Infections / Q000235:genetics / Q000276:immunology / Q000382:microbiology; D001426:Bacterial Proteins / Q000276:immunology / Q000378:metabolism; D003593:Cytoplasm / Q000276:immunology / Q000378:metabolism / Q000382:microbiology; D006790:Host-Parasite Interactions; D006801:Humans; D007113:Immunity, Innate; D008264:Macrophages / Q000276:immunology / Q000378:metabolism / Q000382:microbiology; D053858:Metabolic Networks and Pathways; D035683:MicroRNAs / Q000235:genetics / Q000276:immunology / Q000378:metabolism*
chemical_list: D001426:Bacterial Proteins; D035683:MicroRNAs
keywords: Francisella; Listeria; Mycobacterium; Salmonella; host; macrophages; microRNA; regulation