title: Effect of Heavy Smoking on Dental Implants Placed in Male Patients Posterior Mandibles: A Prospective Clinical Study.
abstract: The objective of this study was to evaluate the implant stability and peri-implant tissue response in heavy smokers receiving dental implants due to partially edentulous posterior mandibles. Forty-five ITI Straumann dental implants were placed into the partially edentulous posterior mandibles of 16 heavy smokers and 16 nonsmokers. One implant in each patient was evaluated for implant stability after surgery and before loading, and for the modified plaque index (mPLI), modified sulcus bleeding index (mSBI), probing depth (PD), and marginal bone loss (MBL) after loading. Meanwhile, the osteogenic capability of jaw marrow samples collected from patients was evaluated via an in vitro mineralization test. For both groups, the implant stability quotient (ISQ) initially decreased from the initial ISQ achieved immediately after surgery and then increased starting from 2 weeks postsurgery. However, at 3, 4, 6, and 8 weeks postsurgery, the ISQ differed significantly between nonsmokers and heavy smokers. All implants achieved osseointegration without complications at least by the end of the 12th week postsurgery. At 6 or 12 months postloading, the MBL and PD were significantly higher in heavy smokers than in nonsmokers, whereas the mSBI and mPLI did not differ significantly between the 2 groups. The 1-year cumulative success rate of implants was 100% for both groups. Within the limitations of the present clinical study (such as small sample size and short study duration), which applied the loading at 3 months postoperation, heavy smoking did not affect the cumulative survival rate of dental implants placed at the posterior mandible in male patients, but heavy smoking did negatively affect bone healing around dental implants by decreasing the healing speed. These results implied that it might be of importance to select the right time point to apply the implant loading for heavy smokers. In addition, heavy smoking promoted the loss of marginal bone and the further development of dental pockets. Further clinical studies with larger patient populations are warranted to confirm our findings over a longer study duration.
authors.affiliation: Department of Oral, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
authors.forename: Cong
authors.initials: C
authors.lastname: Sun
authors.affiliation: Department of Oral, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
authors.forename: Jinxiu
authors.initials: J
authors.lastname: Zhao
authors.affiliation: Department of Oral, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
authors.forename: Chen
authors.initials: C
authors.lastname: Jianghao
authors.affiliation: Department of Oral, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
authors.forename: Tao
authors.initials: T
authors.lastname: Hong
mesh_terms: D015921:Dental Implants; D006801:Humans; D008297:Male; D008334:Mandible; D011446:Prospective Studies; D012907:Smoking / Q000009:adverse effects*
chemical_list: D015921:Dental Implants
keywords: dental implant stability; heavy smoking; resonance frequency analysis