title: Halogenated Sesquiterpenoids from the Red Alga Laurencia tristicha Collected in Taiwan.
abstract: Chemical investigation of the red alga Laurencia tristicha led to the discovery of eight new halogenated chamigrane-type sesquiterpenoids (1-8) and one new bromocuparane-type sesquiterpene (9), along with nine known related metabolites (10-18). Their structures were elucidated on the basis of extensive spectroscopic analyses, and the absolute configurations of 1-8 were proposed by comparison to the biosynthetically related known compound 12. Cytotoxicity, antibacterial, and anti-inflammatory activities of these isolates were also investigated. The results showed that compound 11 exhibited good antibacterial activity against Serratia marcescens compared to the positive control ampicillin at a dosage of 100 μg/disk. Compound 17 showed strong inhibition toward elastase release generation at 10 μM.
authors.forename: Jia-Yu
authors.initials: JY
authors.lastname: Chen
authors.forename: Chiung-Yao
authors.initials: CY
authors.lastname: Huang
authors.affiliation: Department of Biological Science & Technology, Mei Ho University , Pingtung 912, Taiwan.
authors.forename: Yun-Sheng
authors.initials: YS
authors.lastname: Lin
authors.affiliation: Graduate Institute of Natural Products, College of Medicine, Chang Gung University ; Research Center for Industry of Human Ecology and Graduate Institute of Health Industry Technology, Chang Gung University of Science and Technology; and Department of Anesthesiology, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan.
authors.forename: Tsong-Long
authors.initials: TL
authors.lastname: Hwang
authors.affiliation: Department of Biology, National Changhua University of Education , Changhua 500, Taiwan.
authors.forename: Wei-Lung
authors.initials: WL
authors.lastname: Wang
authors.forename: Shu-Fen
authors.initials: SF
authors.lastname: Chiou
authors.affiliation: Institute of Natural Products, Kaohsiung Medical University , Kaohsiung 807, Taiwan.|Department of Medical Research, China Medical University Hospital, China Medical University , Taichung 404, Taiwan.
authors.forename: Jyh-Horng
authors.initials: JH
authors.lastname: Sheu
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D006846:Hydrocarbons, Halogenated / Q000737:chemistry / Q000302:isolation & purification*; D044722:Laurencia / Q000737:chemistry*; D008386:Marine Biology; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D012706:Serratia marcescens / Q000187:drug effects; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013624:Taiwan; D015008:Yersinia enterocolitica / Q000187:drug effects
chemical_list: D000900:Anti-Bacterial Agents; D006846:Hydrocarbons, Halogenated; D012717:Sesquiterpenes