title: Multiparametric imaging with heterogeneous radiofrequency fields.
abstract: Magnetic resonance imaging (MRI) has become an unrivalled medical diagnostic technique able to map tissue anatomy and physiology non-invasively. MRI measurements are meticulously engineered to control experimental conditions across the sample. However, residual radiofrequency (RF) field inhomogeneities are often unavoidable, leading to artefacts that degrade the diagnostic and scientific value of the images. Here we show that, paradoxically, these artefacts can be eliminated by deliberately interweaving freely varying heterogeneous RF fields into a magnetic resonance fingerprinting data-acquisition process. Observations made based on simulations are experimentally confirmed at 7 Tesla (T), and the clinical implications of this new paradigm are illustrated with in vivo measurements near an orthopaedic implant at 3T. These results show that it is possible to perform quantitative multiparametric imaging with heterogeneous RF fields, and to liberate MRI from the traditional struggle for control over the RF field uniformity.
authors.affiliation: Bernard and Irene Schwartz Center for Biomedical Imaging, Center for Advanced Imaging Innovation and Research, Department of Radiology, New York University School of Medicine, 660 1st Avenue, New York, New York 10016, USA.
authors.forename: Martijn A
authors.initials: MA
authors.lastname: Cloos
authors.affiliation: Bernard and Irene Schwartz Center for Biomedical Imaging, Center for Advanced Imaging Innovation and Research, Department of Radiology, New York University School of Medicine, 660 1st Avenue, New York, New York 10016, USA.
authors.forename: Florian
authors.initials: F
authors.lastname: Knoll
authors.affiliation: Bernard and Irene Schwartz Center for Biomedical Imaging, Center for Advanced Imaging Innovation and Research, Department of Radiology, New York University School of Medicine, 660 1st Avenue, New York, New York 10016, USA.|Siemens Medical Solutions USA Inc., 40 Liberty Boulevard, Malvern, Pennsylvania 19355, USA.
authors.forename: Tiejun
authors.initials: T
authors.lastname: Zhao
authors.affiliation: Bernard and Irene Schwartz Center for Biomedical Imaging, Center for Advanced Imaging Innovation and Research, Department of Radiology, New York University School of Medicine, 660 1st Avenue, New York, New York 10016, USA.
authors.forename: Kai T
authors.initials: KT
authors.lastname: Block
authors.affiliation: Bernard and Irene Schwartz Center for Biomedical Imaging, Center for Advanced Imaging Innovation and Research, Department of Radiology, New York University School of Medicine, 660 1st Avenue, New York, New York 10016, USA.
authors.forename: Mary
authors.initials: M
authors.lastname: Bruno
authors.affiliation: Bernard and Irene Schwartz Center for Biomedical Imaging, Center for Advanced Imaging Innovation and Research, Department of Radiology, New York University School of Medicine, 660 1st Avenue, New York, New York 10016, USA.
authors.forename: Graham C
authors.initials: GC
authors.lastname: Wiggins
authors.affiliation: Bernard and Irene Schwartz Center for Biomedical Imaging, Center for Advanced Imaging Innovation and Research, Department of Radiology, New York University School of Medicine, 660 1st Avenue, New York, New York 10016, USA.
authors.forename: Daniel K
authors.initials: DK
authors.lastname: Sodickson
mesh_terms: D016477:Artifacts; D004574:Electromagnetic Fields; D006801:Humans; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D021621:Imaging, Three-Dimensional / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D019047:Phantoms, Imaging; D011846:Radio Waves; D015203:Reproducibility of Results