title: [Research Progress on CALR Mutation in the Myeloproliterative Neoplasm -Review].
abstract: There is no gold diagnostic standard for BCR-ABL fusion gene negative chronic myeloproliterative neoplasm(cMPN). The following detection methods such as comprehensive bone marrow cell morphology, bone marrow pathology, genetic mutation, flow cytometry and immunohistochemical are needed to diagnose the BCR-ABL fusion gene positive cMPN. The JAK2 mutation can be used as a specific diagnostic criteria for polycythemia vera (PV), but there is no specific and sensitive indication for the JAK2 mutation-negative MPN. CALR mutation would be an indication in a certain extent. In this review, the CALR mutation detection, detection mean and its correlation with disease diagnosis and prognosis etc were summarized.
authors.affiliation: Department of Hematology, Hebei People's Hospital, Shijiazhang 050000, Hebei Province, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Yuan
authors.affiliation: Department of Hematology, Hebei People's Hospital, Shijiazhang 050000, Hebei Province, China.E-mail: h0707@163.com.
authors.forename: Hong-Ling
authors.initials: HL
authors.lastname: Hao
authors.affiliation: Department of Hematology, Hebei People's Hospital, Shijiazhang 050000, Hebei Province, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Li
authors.affiliation: Department of Hematology, Hebei People's Hospital, Shijiazhang 050000, Hebei Province, China.
authors.forename: Rui-Cang
authors.initials: RC
authors.lastname: Wang
authors.affiliation: Department of Hematology, Hebei People's Hospital, Shijiazhang 050000, Hebei Province, China.
authors.forename: Xiao-Xia
authors.initials: XX
authors.lastname: Zhang
mesh_terms: D001853:Bone Marrow; D001854:Bone Marrow Cells; D037282:Calreticulin; D006801:Humans; D009154:Mutation; D009196:Myeloproliferative Disorders; D011379:Prognosis
chemical_list: D037282:Calreticulin