title: Effects of Transcranial Magnetic Stimulation on the Hypothalamic-Pituitary Axis in Depression: Results of a Pilot Study.
abstract: Some studies have reported that repetitive transcranial magnetic stimulation (rTMS) applied to the dorsolateral prefrontal cortex (DLPFC) is able to induce changes in the hypothalamic-pituitary axis in subjects with major depression. The causes of these neuroendocrine effects are unknown and deserve to be studied. The authors monitored neuroendocrine hormones in 15 subjects with major depression treated by 1-Hz rTMS on the right DLPFC and explored a correlation with mood improvement. Unlike previous studies, no changes in serum cortisol, prolactin, and thyroid hormone levels were found. However, the authors did observe short-term changes in growth hormone levels in nonresponsive subjects.
authors.affiliation: From the Department of Psychiatry and Addictology, University Hospital of Dijon, Dijon, France (VM, J-C C-G, BB, BT); the Department of Endocrinology, University Hospital of Dijon, Dijon, France (BV); the Department of Psychiatry, University Hospital of Strasbourg, Strasbourg, France (LL); Direction of Clinical Research, University Hospital of Dijon, Dijon, France (LJ); and the Department of Biochemistry, University Hospital of Dijon, Dijon, France (LD).
authors.forename: Vincent
authors.initials: V
authors.lastname: Meille
authors.affiliation: From the Department of Psychiatry and Addictology, University Hospital of Dijon, Dijon, France (VM, J-C C-G, BB, BT); the Department of Endocrinology, University Hospital of Dijon, Dijon, France (BV); the Department of Psychiatry, University Hospital of Strasbourg, Strasbourg, France (LL); Direction of Clinical Research, University Hospital of Dijon, Dijon, France (LJ); and the Department of Biochemistry, University Hospital of Dijon, Dijon, France (LD).
authors.forename: Bruno
authors.initials: B
authors.lastname: Verges
authors.affiliation: From the Department of Psychiatry and Addictology, University Hospital of Dijon, Dijon, France (VM, J-C C-G, BB, BT); the Department of Endocrinology, University Hospital of Dijon, Dijon, France (BV); the Department of Psychiatry, University Hospital of Strasbourg, Strasbourg, France (LL); Direction of Clinical Research, University Hospital of Dijon, Dijon, France (LJ); and the Department of Biochemistry, University Hospital of Dijon, Dijon, France (LD).
authors.forename: Laurence
authors.initials: L
authors.lastname: Lalanne
authors.affiliation: From the Department of Psychiatry and Addictology, University Hospital of Dijon, Dijon, France (VM, J-C C-G, BB, BT); the Department of Endocrinology, University Hospital of Dijon, Dijon, France (BV); the Department of Psychiatry, University Hospital of Strasbourg, Strasbourg, France (LL); Direction of Clinical Research, University Hospital of Dijon, Dijon, France (LJ); and the Department of Biochemistry, University Hospital of Dijon, Dijon, France (LD).
authors.forename: Lysiane
authors.initials: L
authors.lastname: Jonval
authors.affiliation: From the Department of Psychiatry and Addictology, University Hospital of Dijon, Dijon, France (VM, J-C C-G, BB, BT); the Department of Endocrinology, University Hospital of Dijon, Dijon, France (BV); the Department of Psychiatry, University Hospital of Strasbourg, Strasbourg, France (LL); Direction of Clinical Research, University Hospital of Dijon, Dijon, France (LJ); and the Department of Biochemistry, University Hospital of Dijon, Dijon, France (LD).
authors.forename: Laurence
authors.initials: L
authors.lastname: Duvillard
authors.affiliation: From the Department of Psychiatry and Addictology, University Hospital of Dijon, Dijon, France (VM, J-C C-G, BB, BT); the Department of Endocrinology, University Hospital of Dijon, Dijon, France (BV); the Department of Psychiatry, University Hospital of Strasbourg, Strasbourg, France (LL); Direction of Clinical Research, University Hospital of Dijon, Dijon, France (LJ); and the Department of Biochemistry, University Hospital of Dijon, Dijon, France (LD).
authors.forename: Jean-Christophe
authors.initials: JC
authors.lastname: Chavet-Gelinier
authors.affiliation: From the Department of Psychiatry and Addictology, University Hospital of Dijon, Dijon, France (VM, J-C C-G, BB, BT); the Department of Endocrinology, University Hospital of Dijon, Dijon, France (BV); the Department of Psychiatry, University Hospital of Strasbourg, Strasbourg, France (LL); Direction of Clinical Research, University Hospital of Dijon, Dijon, France (LJ); and the Department of Biochemistry, University Hospital of Dijon, Dijon, France (LD).
authors.forename: Bernard
authors.initials: B
authors.lastname: Bonin
authors.affiliation: From the Department of Psychiatry and Addictology, University Hospital of Dijon, Dijon, France (VM, J-C C-G, BB, BT); the Department of Endocrinology, University Hospital of Dijon, Dijon, France (BV); the Department of Psychiatry, University Hospital of Strasbourg, Strasbourg, France (LL); Direction of Clinical Research, University Hospital of Dijon, Dijon, France (LJ); and the Department of Biochemistry, University Hospital of Dijon, Dijon, France (LD).
authors.forename: Benoit
authors.initials: B
authors.lastname: Trojak
mesh_terms: D000328:Adult; D000368:Aged; D003865:Major Depressive Disorder / Q000097:blood* / Q000628:therapy*; D005260:Female; D006728:Hormones / Q000097:blood*; D006801:Humans; D007030:Hypothalamo-Hypophyseal System / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D010865:Pilot Projects; D010913:Pituitary-Adrenal System / Q000503:physiopathology; D011569:Psychiatric Status Rating Scales; D050781:Transcranial Magnetic Stimulation / Q000379:methods*; D016896:Treatment Outcome
chemical_list: D006728:Hormones