title: A new topical panthenol-containing emollient: skin-moisturizing effect following single and prolonged usage in healthy adults, and tolerability in healthy infants.
abstract: OBJECTIVE
  Two studies were conducted with a new topical panthenol-containing emollient (NTP-CE) to investigate the skin-moisturizing effect in healthy adults and tolerability in healthy infants.
  
  
  METHODS
  In Study 1 (N = 44), a single skin application of NTP-CE was performed followed by a 4-week twice-daily application. Skin hydration and stratum corneum (SC) water content change (using Raman spectroscopy) were measured. In the 4-week Study 2 (N = 65, aged 3-25 months), NTP-CE tolerability was assessed using a 5-point scoring system; skin hydration was determined in a subset (N = 21).
  
  
  RESULTS
  In Study 1, mean AUC0 - 24 hfor skin capacitance change from baseline was 302.03 i.u. with NTP-CE and -15.90 i.u. in control areas (p < .001). With NTP-CE (at 4 h), the water content within the upper SC part was reduced (-45.10 vs. -13.39 g/cm2, p = .013) and the water gradient increased (0.51 vs. 0.11 g/cm4, p = .036), indicating relocation of water into deeper layers. In Study 2, there was no statistically significant change from baseline in mean cutaneous tolerability scores. At days 7, 14, and 28, skin hydration had increased by 42%, 54%, and 49%, respectively (all p < .001).
  
  
  CONCLUSIONS
  Single and prolonged NTP-CE usage is associated with sustained and deep skin moisturization. NTP-CE is well tolerated by healthy infants.
authors.affiliation: a Bayer Consumer Care AG , Basel , Switzerland.
authors.forename: Hans
authors.initials: H
authors.lastname: Stettler
authors.affiliation: a Bayer Consumer Care AG , Basel , Switzerland.
authors.forename: Peter
authors.initials: P
authors.lastname: Kurka
authors.affiliation: b proDERM Institute for Applied Dermatological Research , Schenefeld/Hamburg , Germany.
authors.forename: Christine
authors.initials: C
authors.lastname: Wagner
authors.affiliation: c Dermscan Poland Sp. z o.o, Ul , Gdansk , Poland.
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Sznurkowska
authors.affiliation: c Dermscan Poland Sp. z o.o, Ul , Gdansk , Poland.
authors.forename: Olga
authors.initials: O
authors.lastname: Czernicka
authors.affiliation: b proDERM Institute for Applied Dermatological Research , Schenefeld/Hamburg , Germany.
authors.forename: Arne
authors.initials: A
authors.lastname: Böhling
authors.affiliation: b proDERM Institute for Applied Dermatological Research , Schenefeld/Hamburg , Germany.
authors.forename: Stephan
authors.initials: S
authors.lastname: Bielfeldt
authors.affiliation: b proDERM Institute for Applied Dermatological Research , Schenefeld/Hamburg , Germany.
authors.forename: Klaus-Peter
authors.initials: KP
authors.lastname: Wilhelm
authors.affiliation: a Bayer Consumer Care AG , Basel , Switzerland.
authors.forename: Holger
authors.initials: H
authors.lastname: Lenz
mesh_terms: D000287:Administration, Topical; D000293:Adolescent; D000328:Adult; D019540:Area Under Curve; D004643:Emollients / Q000737:chemistry / Q000494:pharmacology*; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D008875:Middle Aged; D010205:Pantothenic Acid / Q000737:chemistry*; D012372:ROC Curve; D012867:Skin / Q000737:chemistry / Q000187:drug effects* / Q000378:metabolism; D013059:Spectrum Analysis, Raman; D014867:Water / Q000737:chemistry / Q000378:metabolism; D055815:Young Adult
chemical_list: D004643:Emollients; D014867:Water; D010205:Pantothenic Acid
keywords: Emollient; infants; moisturization; panthenol; skin; tolerability; topical