title: Anaphylactic reaction due to cefuroxime axetil: A rare cause of anaphylaxis.
abstract: One of the most used cephalosporins in clinical practice is cefuroxime axetil. Anaphylaxis due to the administration of cefuroxime is considered a rare event. We report a case of anaphylactic reaction after the administration of cefuroxime in a child who had tolerated the drug in past exposures. Diagnostic workup is recommended for all patients with at least a moderate anaphylactic reaction (hypotension, tachycardia, bronchial hyperreactivity). This should include a detailed history of the event, previous allergies, and underlying conditions. Unfortunately, all currently available diagnostic approaches (IgE, skin-prick-test, tryptase) leave a significant percentage of non-diagnostic results and false positive or negative outcomes.
authors.affiliation: Department of Paediatrics. Segovia General Hospital, Segovia, Spain pablitovg@hotmail.com.
authors.forename: Pablo
authors.initials: P
authors.lastname: Del Villar-Guerra
authors.affiliation: Department of Paediatrics. Segovia General Hospital, Segovia, Spain.
authors.forename: Blanca
authors.initials: B
authors.lastname: Moreno Vicente-Arche
authors.affiliation: Department of Paediatrics. Segovia General Hospital, Segovia, Spain.
authors.forename: Sara
authors.initials: S
authors.lastname: Castrillo Bustamante
authors.affiliation: Department of Paediatrics. Segovia General Hospital, Segovia, Spain.
authors.forename: Carlos
authors.initials: C
authors.lastname: Santana Rodríguez
mesh_terms: D000707:Anaphylaxis / Q000139:chemically induced*; D002444:Cefuroxime / Q000009:adverse effects / Q000031:analogs & derivatives*; D002511:Cephalosporins / Q000009:adverse effects; D002648:Child; D005260:Female; D006801:Humans; D012882:Skin Tests / Q000379:methods
chemical_list: D002511:Cephalosporins; D002444:Cefuroxime; C040738:cefuroxime axetil
keywords: anaphylactic reaction; anaphylaxis; antibiotic; cephalosporins