title: Cafeteria diet induce changes in blood flow that are more related with heat dissipation than energy accretion.
abstract: Background. A "cafeteria" diet is a self-selected high-fat diet, providing an excess of energy, which can induce obesity. Excess of lipids in the diet hampers glucose utilization eliciting insulin resistance, which, further limits amino acid oxidation for energy. Methods. Male Wistar rats were exposed for a month to "cafeteria" diet. Rats were cannulated and fluorescent microspheres were used to determine blood flow. Results. Exposure to the cafeteria diet did not change cardiac output, but there was a marked shift in organ irrigation. Skin blood flow decreased to compensate increases in lungs and heart. Blood flow through adipose tissue tended to increase in relation to controls, but was considerably increased in brown adipose tissue (on a weight basis). Discussion. The results suggest that the cafeteria diet-induced changes were related to heat transfer and disposal.
authors.affiliation: Department of Biochemistry an Molecular Biomedicine, Faculty of Biology, Universitat de Barcelona , Barcelona , Spain.
authors.forename: David
authors.initials: D
authors.lastname: Sabater
authors.affiliation: Department of Biochemistry an Molecular Biomedicine, Faculty of Biology, Universitat de Barcelona , Barcelona , Spain.
authors.forename: Silvia
authors.initials: S
authors.lastname: Agnelli
authors.affiliation: Department of Biochemistry an Molecular Biomedicine, Faculty of Biology, Universitat de Barcelona , Barcelona , Spain.
authors.forename: Sofía
authors.initials: S
authors.lastname: Arriarán
authors.affiliation: Department of Biochemistry an Molecular Biomedicine, Faculty of Biology, Universitat de Barcelona, Barcelona, Spain; CIBER OBN Research Network, Barcelona, Spain.
authors.forename: María Del Mar
authors.initials: Mdel M
authors.lastname: Romero
authors.affiliation: Department of Biochemistry an Molecular Biomedicine, Faculty of Biology, Universitat de Barcelona, Barcelona, Spain; CIBER OBN Research Network, Barcelona, Spain; Institute of Biomedicine, Universitat de Barcelona, Barcelona, Spain.
authors.forename: José Antonio
authors.initials: JA
authors.lastname: Fernández-López
authors.affiliation: Department of Biochemistry an Molecular Biomedicine, Faculty of Biology, Universitat de Barcelona, Barcelona, Spain; CIBER OBN Research Network, Barcelona, Spain; Institute of Biomedicine, Universitat de Barcelona, Barcelona, Spain.
authors.forename: Marià
authors.initials: M
authors.lastname: Alemany
authors.affiliation: Department of Biochemistry an Molecular Biomedicine, Faculty of Biology, Universitat de Barcelona, Barcelona, Spain; CIBER OBN Research Network, Barcelona, Spain; Institute of Biomedicine, Universitat de Barcelona, Barcelona, Spain.
authors.forename: Xavier
authors.initials: X
authors.lastname: Remesar
keywords: Cafeteria diet; Flux; Rat; Tissue blood flow