title: [Therapeutic Effects of Multipotent Mesenchymal Stromal Cells after Irradiation].
abstract: Multipotent mesenchymal stromal cells (MSC) are now considered to be a perspective multifunctional treatment option for radiation side effects. At present.a great number of sufficient evidence has been collected in favor of therapeutic effects of MSCs in acute radiation reactions. It has been shown that MSC-based products injected locally or systemically have therapeutic effects on irradiated organs and tissues. This review presents summarized experimental and clinical data about protective and regenerative effects of MSCs on different radiation-injured organs and tissues; the main probable therapeutic mechanisms of their action are also discussed.
authors.forename: N V
authors.initials: NV
authors.lastname: Kalmykova
authors.forename: S A
authors.initials: SA
authors.lastname: Alexandrova
mesh_terms: D000818:Animals; D064987:Cell- and Tissue-Based Therapy; D006801:Humans; D045164:Mesenchymal Stem Cell Transplantation; D059630:Mesenchymal Stem Cells / Q000166:cytology / Q000528:radiation effects; D011832:Radiation Injuries / Q000628:therapy*; D011839:Radiation, Ionizing