title: Lobe-Specific Lymph Node Dissection as a Standard Procedure in Surgery for Non-Small Cell Lung Cancer: A Propensity Score Matching Study.
abstract: Systematic lymph node dissection (SND) is the standard procedure in surgical treatment for NSCLC, but the value of this approach for survival and nodal staging is still uncertain. In this study, we evaluated the potential of lobe-specific lymph node dissection (L-SND) in surgery for NSCLC by using a propensity score matching method.
  
  
  
  From 2005 to 2007, 565 patients with cT1a-2b N0-1 M0 NSCLC underwent lobectomy with lymph node dissection at our 10 affiliated hospitals. Patients were classified into groups that underwent nodal sampling, L-SND, and systematic dissection SND on the basis of pathological data for the number and extent of nodal resection. A total of 77 patients with insufficient pathological data were excluded from the study.
  
  
  
  Overall, survival did not differ significantly among the groups (p = 0.552), but the rate of detection of pN2 in the SND group (13.1%) was significantly higher than in the nodal sampling (3.3%) and L-SND (9.0%) groups (p = 0.010). However, given the many confounding factors in the patient characteristics in each group, outcomes were reevaluated using a propensity score matching method for the L-SND and SND groups. After matching, the two groups had no significant differences in 5-year overall survival (73.5% for L-SND versus 75.3% for SND, p = 0.977) and pN2 detection (8.2% in both groups, p = 0.779).
  
  
  
  These results suggest that lobe-specific lymph node dissection has the potential to be a standard procedure in surgical treatment for NSCLC.
authors.affiliation: Department of Surgery, Yokohama City University, Yokohama, Japan. Electronic address: adachi-fam@m2.gyao.ne.jp.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Adachi
authors.affiliation: Department of Biostatistics, Yokohama City University Graduate School of Medicine, Yokohama, Japan.
authors.forename: Kentaro
authors.initials: K
authors.lastname: Sakamaki
authors.affiliation: Department of Surgery, Yokohama City University, Yokohama, Japan.
authors.forename: Teppei
authors.initials: T
authors.lastname: Nishii
authors.affiliation: Department of Surgery, Yokohama City University, Yokohama, Japan.
authors.forename: Taketsugu
authors.initials: T
authors.lastname: Yamamoto
authors.affiliation: Department of Surgery, Yokohama City University, Yokohama, Japan.
authors.forename: Takuya
authors.initials: T
authors.lastname: Nagashima
authors.affiliation: Department of Surgery, Yokohama City University, Yokohama, Japan.
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Ishikawa
authors.affiliation: Department of Surgery, Yokohama City University, Yokohama, Japan.
authors.forename: Kohei
authors.initials: K
authors.lastname: Ando
authors.affiliation: Department of Surgery, Yokohama City University, Yokohama, Japan.
authors.forename: Kazuki
authors.initials: K
authors.lastname: Yamanaka
authors.affiliation: Department of Surgery, Yokohama City University, Yokohama, Japan.
authors.forename: Katsuya
authors.initials: K
authors.lastname: Watanabe
authors.affiliation: Department of Surgery, Yokohama City University, Yokohama, Japan.
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Kumakiri
authors.affiliation: Department of Surgery, Yokohama City University, Yokohama, Japan; Division of Thoracic Surgery, National Cancer Center Hospital East, Kashiwa, Japan.
authors.forename: Masahiro
authors.initials: M
authors.lastname: Tsuboi
authors.affiliation: Department of Surgery, Yokohama City University, Yokohama, Japan.
authors.forename: Takamitsu
authors.initials: T
authors.lastname: Maehara
authors.affiliation: Department of Surgery, Yokohama City University, Yokohama, Japan.
authors.forename: Haruhiko
authors.initials: H
authors.lastname: Nakayama
authors.affiliation: Department of Surgery, Yokohama City University, Yokohama, Japan.
authors.forename: Munetaka
authors.initials: M
authors.lastname: Masuda
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology / Q000601:surgery; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D018287:Carcinoma, Large Cell / Q000473:pathology / Q000601:surgery; D002289:Carcinoma, Non-Small-Cell Lung / Q000473:pathology / Q000601:surgery*; D002294:Carcinoma, Squamous Cell / Q000473:pathology / Q000601:surgery; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008175:Lung Neoplasms / Q000473:pathology / Q000601:surgery*; D008197:Lymph Node Excision / Q000379:methods*; D008198:Lymph Nodes / Q000473:pathology / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011013:Pneumonectomy; D011379:Prognosis; D057216:Propensity Score; D029424:Pulmonary Disease, Chronic Obstructive / Q000473:pathology / Q000601:surgery; D015996:Survival Rate
keywords: Lymph node dissection; Lymph node sampling; NSCLC; Nodal dissection; Nodal sampling