title: Helicobacter pylori in children.
abstract: Helicobacter pylori infection in early childhood may differ in many aspects compared to infection in adulthood: the immune response in the gut, the type and prevalence of complications within and outside the stomach, and the impact on long-term health. In high prevalence countries, transient infections seem to be common in infants and toddlers, and the consequences of this phenomenon on the short- and long-term immune response are still unclear. Other controversial issues are related to the question of which H. pylori-infected children benefit from treatment and which is the best regimen to eradicate the infection in the presence of a worldwide increasing antibiotic resistance. The first large-scale randomized placebo-controlled vaccination trial in schoolchildren indicates that prevention of the infection may be possible.
authors.affiliation: Division of Gastroenterology and Hepatology, Dr. v. Hauner Children's Hospital, Ludwig Maximilians University Munich, Munich, Germany.
authors.forename: Andrea
authors.initials: A
authors.lastname: Sustmann
authors.affiliation: Department of General Medicine and Community Health Science, Sasayama Medical Center, Hyogo College of Medicine, Sasayama, Hyogo, Japan.
authors.forename: Masumi
authors.initials: M
authors.lastname: Okuda
authors.affiliation: Division of Gastroenterology and Hepatology, Dr. v. Hauner Children's Hospital, Ludwig Maximilians University Munich, Munich, Germany.
authors.forename: Sibylle
authors.initials: S
authors.lastname: Koletzko
mesh_terms: D000293:Adolescent; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D018849:Controlled Clinical Trials as Topic; D024881:Drug Resistance, Bacterial; D016481:Helicobacter Infections / Q000150:complications / Q000188:drug therapy / Q000453:epidemiology* / Q000517:prevention & control; D006801:Humans; D007223:Infant; D016896:Treatment Outcome; D014611:Vaccination / Q000379:methods
chemical_list: D000900:Anti-Bacterial Agents
keywords: diagnosis; epidemiology; pathophysiology; treatment