title: The effect of low-carbohydrates calorie-restricted diet on visceral adipose tissue and metabolic status in psoriasis patients receiving TNF-alpha inhibitors: results of an open label controlled, prospective, clinical study.
abstract: OBJECTIVE
  TNF alpha inhibitors are usually associated with anthropometric changes over the time, however whether and how the visceral adipose tissue (VAT) is involved in this phenomenon, still remains unclear. Aim of the study is to evaluate if the increases in trunk fat percentage (TF%) and VAT are directly involved in anthropometric changes occurring during treatment, and whether and how a calorie restricted diet could prevent these changes.
  
  
  METHODS
  Twenty patients receiving TNF-alpha inhibitors for psoriasis was evaluated at baseline (T0) and after 24 weeks of therapy (T24), and then compared with 25 patients receiving a combined treatment based on TNF alpha inhibitors and low-carbohydrates calorie-restricted diet.
  
  
  RESULTS
  TNF-alpha inhibitors do not influence the VAT expression. The combined treatment is associated with a significant decrease in body weight (kg) (p < .0001), BMI (p = .0001), WC (cm) (p < .0001), TF% (p < .0001), VAT (p < .0001), serum levels of triglycerides (mg/dL) (p = .0018) and total cholesterol (mg/dL) (p = .0005).
  
  
  CONCLUSIONS
  The administration of TNF-alpha inhibitors can induce anthropometric changes after 24 weeks, but it does not cause an increase in VAT. The association between low-carbohydrates calorie-restricted diet and anti-TNF-alpha therapy seems to be able to improve the anthropometric profile of psoriasis patients.
authors.affiliation: a Dermatology Unit, Department of Clinical and Molecular Sciences , Polytechnic Marche University , Ancona , Italy.
authors.forename: A
authors.initials: A
authors.lastname: Campanati
authors.affiliation: a Dermatology Unit, Department of Clinical and Molecular Sciences , Polytechnic Marche University , Ancona , Italy.
authors.forename: E
authors.initials: E
authors.lastname: Molinelli
authors.affiliation: a Dermatology Unit, Department of Clinical and Molecular Sciences , Polytechnic Marche University , Ancona , Italy.
authors.forename: G
authors.initials: G
authors.lastname: Ganzetti
authors.affiliation: a Dermatology Unit, Department of Clinical and Molecular Sciences , Polytechnic Marche University , Ancona , Italy.
authors.forename: K
authors.initials: K
authors.lastname: Giuliodori
authors.affiliation: a Dermatology Unit, Department of Clinical and Molecular Sciences , Polytechnic Marche University , Ancona , Italy.
authors.forename: I
authors.initials: I
authors.lastname: Minetti
authors.affiliation: b Dietetic and Nutritional Unit, Department of Surgery and Medical Sciences , United Hospitals of Ancona , Italy.
authors.forename: M
authors.initials: M
authors.lastname: Taus
authors.affiliation: b Dietetic and Nutritional Unit, Department of Surgery and Medical Sciences , United Hospitals of Ancona , Italy.
authors.forename: M
authors.initials: M
authors.lastname: Catani
authors.affiliation: a Dermatology Unit, Department of Clinical and Molecular Sciences , Polytechnic Marche University , Ancona , Italy.
authors.forename: E
authors.initials: E
authors.lastname: Martina
authors.affiliation: a Dermatology Unit, Department of Clinical and Molecular Sciences , Polytechnic Marche University , Ancona , Italy.
authors.forename: L
authors.initials: L
authors.lastname: Conocchiari
authors.affiliation: a Dermatology Unit, Department of Clinical and Molecular Sciences , Polytechnic Marche University , Ancona , Italy.
authors.forename: A
authors.initials: A
authors.lastname: Offidani
mesh_terms: D000328:Adult; D000368:Aged; D015992:Body Mass Index; D001835:Body Weight; D002784:Cholesterol / Q000097:blood; D050528:Diet, Carbohydrate-Restricted; D005260:Female; D006801:Humans; D050152:Intra-Abdominal Fat / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D009765:Obesity; D011446:Prospective Studies; D011565:Psoriasis / Q000188:drug therapy* / Q000473:pathology; D014280:Triglycerides / Q000097:blood; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors* / Q000378:metabolism
chemical_list: D014280:Triglycerides; D014409:Tumor Necrosis Factor-alpha; D002784:Cholesterol
keywords: Psoriasis; TNF alpha inhibitors; low-carbohydrates calories restricted diet; visceral adipose tissue