title: Macroscopic singlet oxygen modeling for dosimetry of Photofrin-mediated photodynamic therapy: an in-vivo study.
abstract: Although photodynamic therapy (PDT) is an established modality for cancer treatment, current dosimetric quantities, such as light fluence and PDT dose, do not account for the differences in PDT oxygen consumption for different fluence rates ( ? ). A macroscopic model was adopted to evaluate using calculated reacted singlet oxygen concentration ( [ O 2 1 ] rx ) to predict Photofrin-PDT outcome in mice bearing radiation-induced fibrosarcoma tumors, as singlet oxygen is the primary cytotoxic species responsible for cell death in type II PDT. Using a combination of fluences (50, 135, 200, and 250 ?? J / cm 2 ) and ? (50, 75, and 150 ?? mW / cm 2 ), tumor regrowth rate, k , was determined for each condition. A tumor cure index, CI = 1 ? k / k control , was calculated based on the k between PDT-treated groups and that of the control, Available on the SPIE Digital Library.
authors.affiliation: Chinese PLA General Hospital, Department of Laser Medicine, No. 28 Fuxing Road, Haidian District, Beijing 100853, ChinabUniversity of Pennsylvania, School of Medicine, Department of Radiation Oncology, 3400 Civic Center Boulevard TRC 4W, Philadelphia, Pennsylvania 19104, United States.
authors.forename: Haixia
authors.initials: H
authors.lastname: Qiu
authors.affiliation: University of Pennsylvania, School of Medicine, Department of Radiation Oncology, 3400 Civic Center Boulevard TRC 4W, Philadelphia, Pennsylvania 19104, United StatescUniversity of Pennsylvania, Department of Physics and Astronomy, 209 South 33rd Street, Philadelphia, Pennsylvania 19104, United States.
authors.forename: Michele M
authors.initials: MM
authors.lastname: Kim
authors.affiliation: University of Pennsylvania, School of Medicine, Department of Radiation Oncology, 3400 Civic Center Boulevard TRC 4W, Philadelphia, Pennsylvania 19104, United States.
authors.forename: Rozhin
authors.initials: R
authors.lastname: Penjweini
authors.affiliation: University of Pennsylvania, School of Medicine, Department of Radiation Oncology, 3400 Civic Center Boulevard TRC 4W, Philadelphia, Pennsylvania 19104, United States.
authors.forename: Timothy C
authors.initials: TC
authors.lastname: Zhu
mesh_terms: D000818:Animals; D017323:Dihematoporphyrin Ether / Q000493:pharmacokinetics / Q000627:therapeutic use; D005260:Female; D051379:Mice; D008809:Mice, Inbred C3H; D008954:Models, Biological; D009374:Neoplasms, Experimental / Q000737:chemistry / Q000378:metabolism / Q000532:radiotherapy; D010778:Photochemotherapy / Q000379:methods*; D017319:Photosensitizing Agents / Q000493:pharmacokinetics / Q000627:therapeutic use; D011829:Radiation Dosage; D026082:Singlet Oxygen / Q000032:analysis* / Q000378:metabolism; D023041:Xenograft Model Antitumor Assays
chemical_list: D017319:Photosensitizing Agents; D026082:Singlet Oxygen; D017323:Dihematoporphyrin Ether