title: Mesenchymal Stem Cells and Myeloid Derived Suppressor Cells: Common Traits in Immune Regulation.
abstract: To protect host against immune-mediated damage, immune responses are tightly regulated. The regulation of immune responses is mediated by various populations of mature immune cells, such as T regulatory cells and B regulatory cells, but also by immature cells of different origins. In this review, we discuss regulatory properties and mechanisms whereby two distinct populations of immature cells, mesenchymal stem cells, and myeloid derived suppressor cells mediate immune regulation, focusing on their similarities, discrepancies, and potential clinical applications.
authors.affiliation: Central Tuberculosis Research Institute, Yauza Alley 2, Moscow 107564, Russia.
authors.forename: Irina Lyadova
authors.identifier: 0000-0003-3147-5386
authors.initials: IL
authors.lastname: Vladimirovna
authors.affiliation: Central Tuberculosis Research Institute, Yauza Alley 2, Moscow 107564, Russia.
authors.forename: Ekaterina
authors.identifier: 0000-0002-0328-7962
authors.initials: E
authors.lastname: Sosunova
authors.affiliation: Central Tuberculosis Research Institute, Yauza Alley 2, Moscow 107564, Russia.
authors.forename: Alexander
authors.initials: A
authors.lastname: Nikolaev
authors.affiliation: Central Tuberculosis Research Institute, Yauza Alley 2, Moscow 107564, Russia.
authors.forename: Tatiana
authors.identifier: 0000-0002-1669-5244
authors.initials: T
authors.lastname: Nenasheva
mesh_terms: D000818:Animals; D015415:Biomarkers; D002454:Cell Differentiation; D016207:Cytokines / Q000378:metabolism; D005786:Gene Expression Regulation; D006801:Humans; D007107:Immune System / Q000166:cytology / Q000276:immunology / Q000378:metabolism; D056747:Immunomodulation / Q000235:genetics; D016131:Lymphocyte Subsets / Q000276:immunology / Q000378:metabolism; D059630:Mesenchymal Stem Cells / Q000166:cytology / Q000276:immunology* / Q000378:metabolism*; D000072737:Myeloid-Derived Suppressor Cells / Q000276:immunology* / Q000378:metabolism*; D010084:Oxidation-Reduction
chemical_list: D015415:Biomarkers; D016207:Cytokines