title: Insect Antifeedant and Ixodicidal Compounds from Senecio adenotrichius.
abstract: Nine eremophilane sesquiterpenes 1 - 9, two flavonoids 11 and 12, and two known pirrolizidine alkaloids 13 and 14, were isolated from Senecio adenotrichius DC. Their structures were elucidated on the basis of spectroscopic data and by comparison with previously reported spectroscopic data of similar compounds. Compounds 5, 7, and 9 have not been previously reported as natural products. The antifeedant activity of these compounds was tested against Spodoptera litoralis and Myzus persicae. Eremophilanes 1, 3, and 8 were strong antifeedants to M. persicae, and 1 and 8 to Spodoptera littoralis. Their ixodicidal activity was tested against the tick Hyalomma lusitanicum, with eremophilanes 1, 3, and 8, being strong ixodicidal agents.
authors.affiliation: Instituto de Productos Naturales y Agrobiología (IPNA) (CSIC), ES-38206, La Laguna, Tenerife, Spain.
authors.forename: Liliana
authors.initials: L
authors.lastname: Ruiz-Vásquez
authors.affiliation: Facultad de Veterinaria, Universidad Complutense (UCM), Madrid, Spain.
authors.forename: Angeles Sonia
authors.initials: AS
authors.lastname: Olmeda
authors.affiliation: Facultad de Química y Biología, Universidad de Santiago de Chile (USACH), Santiago, Chile.
authors.forename: Gustavo
authors.initials: G
authors.lastname: Zúñiga
authors.affiliation: Facultad de Química y Biología, Universidad de Santiago de Chile (USACH), Santiago, Chile.
authors.forename: Luis
authors.initials: L
authors.lastname: Villarroel
authors.affiliation: Facultad de Ciencias Exactas y Naturales, Instituto de Química, Universidad de Antioquia, Medellín, Colombia.
authors.forename: Luis Fernando
authors.initials: LF
authors.lastname: Echeverri
authors.affiliation: Instituto de Ciencias Agrarias (ICA), CSIC, ES-28006, Madrid, Spain.
authors.forename: Azucena
authors.initials: A
authors.lastname: González-Coloma
authors.affiliation: Instituto de Productos Naturales y Agrobiología (IPNA) (CSIC), ES-38206, La Laguna, Tenerife, Spain.
authors.forename: Matías
authors.initials: M
authors.lastname: Reina
mesh_terms: D000470:Alkaloids / Q000302:isolation & purification / Q000494:pharmacology; D000818:Animals; D001042:Aphids / Q000187:drug effects; D005419:Flavonoids / Q000302:isolation & purification / Q000494:pharmacology; D007306:Insecticides / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D010936:Plant Extracts / Q000737:chemistry; D012674:Senecio / Q000737:chemistry*; D012717:Sesquiterpenes / Q000302:isolation & purification / Q000494:pharmacology; D018411:Spodoptera / Q000187:drug effects; D013329:Structure-Activity Relationship
chemical_list: D000470:Alkaloids; D005419:Flavonoids; D007306:Insecticides; D010936:Plant Extracts; D012717:Sesquiterpenes
keywords: 
  Senecio adenotrichius
  ; Antifeedant; Eremophilanes; Ixodicidal