title: Collective Synthesis of Phenanthridinone through C-H Activation Involving a Pd-Catalyzed Aryne Multicomponent Reaction.
abstract: A palladium-catalyzed multicomponent reaction (MCR) involving aryne, CO, and aniline is established for straightforward assembly of a phenanthridinone scaffold through C-H bond activation. Free combination with multiple kinds of readily available anilines and arynes is facilely achieved for phenanthridinone construction without prefunctionalization. Representative natural products were subsequently synthesized through this MCR strategy highly efficiently. Control experiments and interval NMR tracking revealed the mechanism, particularly the key role of CuF2 in determining the aryne-releasing rate from the precursor in this transformation.
authors.affiliation: Shanghai Key Laboratory of Green Chemistry and Chemical Process, School of Chemistry and Molecular Engineering, East China Normal University , 3663 North Zhongshan Road, Shanghai, 200062, P. R. China.
authors.forename: Minghao
authors.initials: M
authors.lastname: Feng
authors.affiliation: Shanghai Key Laboratory of Green Chemistry and Chemical Process, School of Chemistry and Molecular Engineering, East China Normal University , 3663 North Zhongshan Road, Shanghai, 200062, P. R. China.
authors.forename: Bingqing
authors.initials: B
authors.lastname: Tang
authors.affiliation: School of Pharmacy, Shanghai University of Traditional Chinese Medicine , Cai Lun Lu 1200, Shanghai 201203, P. R. China.
authors.forename: Hong-Xi
authors.initials: HX
authors.lastname: Xu
authors.affiliation: Shanghai Key Laboratory of Green Chemistry and Chemical Process, School of Chemistry and Molecular Engineering, East China Normal University , 3663 North Zhongshan Road, Shanghai, 200062, P. R. China.|State Key Laboratory of Elemento-organic Chemistry, Nankai University , Tianjin 300071, P. R. China.
authors.forename: Xuefeng
authors.initials: X
authors.lastname: Jiang