title: Notch-mediated lateral inhibition regulates proneural wave propagation when combined with EGF-mediated reaction diffusion.
abstract: Notch-mediated lateral inhibition regulates binary cell fate choice, resulting in salt and pepper patterns during various developmental processes. However, how Notch signaling behaves in combination with other signaling systems remains elusive. The wave of differentiation in the Drosophila visual center or "proneural wave" accompanies Notch activity that is propagated without the formation of a salt and pepper pattern, implying that Notch does not form a feedback loop of lateral inhibition during this process. However, mathematical modeling and genetic analysis clearly showed that Notch-mediated lateral inhibition is implemented within the proneural wave. Because partial reduction in EGF signaling causes the formation of the salt and pepper pattern, it is most likely that EGF diffusion cancels salt and pepper pattern formation in silico and in vivo. Moreover, the combination of Notch-mediated lateral inhibition and EGF-mediated reaction diffusion enables a function of Notch signaling that regulates propagation of the wave of differentiation.
authors.affiliation: Mathematical Neuroscience Unit, Institute for Frontier Science Initiative, Kanazawa University, Ishikawa 920-8640, Japan; Laboratory of Developmental Neurobiology, Graduate School of Medical Sciences, Brain/Liver Interface Medicine Research Center, Kanazawa University, Ishikawa 920-8640, Japan; Core Research for Evolutional Science and Technology, Japan Science and Technology Agency, Saitama 332-0012, Japan; makotos@staff.kanazawa-u.ac.jp.
authors.forename: Makoto
authors.initials: M
authors.lastname: Sato
authors.affiliation: Mathematical Neuroscience Unit, Institute for Frontier Science Initiative, Kanazawa University, Ishikawa 920-8640, Japan;
authors.forename: Tetsuo
authors.initials: T
authors.lastname: Yasugi
authors.affiliation: Graduate School of Science, Hokkaido University, Hokkaido 060-0810, Japan;
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Minami
authors.affiliation: Core Research for Evolutional Science and Technology, Japan Science and Technology Agency, Saitama 332-0012, Japan; Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan;
authors.forename: Takashi
authors.initials: T
authors.lastname: Miura
authors.affiliation: Core Research for Evolutional Science and Technology, Japan Science and Technology Agency, Saitama 332-0012, Japan; Research Institute for Electronic Science, Hokkaido University, Hokkaido 060-0811, Japan.
authors.forename: Masaharu
authors.initials: M
authors.lastname: Nagayama
mesh_terms: D058145:Achaete-Scute Complex Genome Region / Q000235:genetics; D000465:Algorithms; D000818:Animals; D030801:Animals, Genetically Modified; D002454:Cell Differentiation / Q000235:genetics; D029721:Drosophila Proteins / Q000235:genetics / Q000378:metabolism*; D004331:Drosophila melanogaster / Q000235:genetics / Q000378:metabolism; D004815:Epidermal Growth Factor / Q000235:genetics / Q000378:metabolism*; D008959:Models, Neurological; D058953:Neural Stem Cells / Q000166:cytology / Q000378:metabolism; D046569:Neuroepithelial Cells / Q000166:cytology / Q000378:metabolism; D055495:Neurogenesis / Q000235:genetics; D051880:Receptors, Notch / Q000235:genetics / Q000378:metabolism*; D012160:Retina / Q000166:cytology / Q000378:metabolism; D015398:Signal Transduction; D013477:Superior Colliculi / Q000166:cytology / Q000378:metabolism; D014793:Visual Cortex / Q000166:cytology / Q000378:metabolism
chemical_list: D029721:Drosophila Proteins; D051880:Receptors, Notch; D004815:Epidermal Growth Factor
keywords: EGF; Notch; lateral inhibition; proneural wave; reaction diffusion