title: Effect of resveratrol and environmental enrichment on biomarkers of oxidative stress in young healthy mice.
abstract: Resveratrol (RESV) and Environmental Enrichment (EE) have been separately reported to protect organisms against various diseases. This study investigated the potential benefit of the combination of RESV and EE on biomarkers of oxidative stress in young healthy mice. Fifty mice of both sexes were randomly divided into five groups of 10 animals each: group I served as control, group II were maintained on alternate day feeding, group III received RESV 50 mg/kg, suspended in caboxymethylcellulose orally per kg/day. Group IV received CMC and kept in an Enriched Environment, group V received RESV + EE. The treatment lasted for 28 days. The animals were sacrificed 24 h after the last treatment and brain samples were collected for biochemical evaluation. The results obtained showed a significant decrease (P < 0.05) in malondialdehyde concentration in EE group and RESV treated group kept EE when compared to the control. A significant decrease was also observed in glutathione peroxidase activity in all the treatment groups when compared to the control. A significant decrease in GPx activities in RESV, EE and RESV + EE treated groups in male and female mice when compared to the control groups respectively. However, a significant increase in GPx activities was observed in EE group in male mice and EODF, RESV groups in female mice when compared to RESV + EE groups respectively. In conclusion, the result of our study indicates that EE possesses antioxidant properties by decreasing MDA concentration and attenuating lipid peroxidation in the brain of young Swiss albino mice.
authors.affiliation: Department of Human Physiology, College of Medical Sciences, Gombe State University, Gombe, Nigeria. mshehu84@gmail.com.
authors.forename: Mustapha Shehu
authors.identifier: 0000-0001-9149-8462
authors.initials: MS
authors.lastname: Muhammad
authors.affiliation: Department of Human Physiology, Faculty of Medicine, Ahmadu Bello University, Zaria, Nigeria.
authors.forename: Rabiu Abdussalam
authors.initials: RA
authors.lastname: Magaji
authors.affiliation: Department of Human Physiology, Faculty of Medicine, Ahmadu Bello University, Zaria, Nigeria.
authors.forename: Aliyu
authors.initials: A
authors.lastname: Mohammed
authors.affiliation: Department of Human Physiology, Faculty of Medicine, Ahmadu Bello University, Zaria, Nigeria.
authors.forename: Ahmed-Sherif
authors.initials: AS
authors.lastname: Isa
authors.affiliation: Department of Pharmacology and Therapeutics, Faculty of Pharmaceutical Sciences, Ahmadu Bello University, Zaria, Nigeria.
authors.forename: Mohammed Garba
authors.initials: MG
authors.lastname: Magaji
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D015415:Biomarkers / Q000378:metabolism; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D004777:Environment; D005979:Glutathione Peroxidase / Q000378:metabolism; D006799:Housing, Animal; D015227:Lipid Peroxidation / Q000187:drug effects*; D008315:Malondialdehyde / Q000378:metabolism; D051379:Mice; D018384:Oxidative Stress / Q000187:drug effects* / Q000502:physiology; D000077185:Resveratrol; D013267:Stilbenes / Q000494:pharmacology*
chemical_list: D000975:Antioxidants; D015415:Biomarkers; D013267:Stilbenes; D008315:Malondialdehyde; D005979:Glutathione Peroxidase; D000077185:Resveratrol
keywords: Antioxidant enzymes; Environmental enrichment; Lipid peroxidation; Oxidative stress; Resveratrol