title: Extracorporeal blood purification for sepsis.
abstract: It has been speculated that extracorporeal blood purification therapies might improve the clinical outcome for patients with severe sepsis, with or without acute kidney injury, since the removal of inflammatory mediators and/or bacterial toxins from circulation could modulate the inflammatory responses that result in organ damage. Despite initial enthusiasm based on promising preliminary results, subsequent investigations did not show sustainable survival benefit. We review the principles and development of blood purification techniques for sepsis and septic acute kidney injury.
authors.affiliation: Department of Intensive Care, Pamela Youde Nethersole Eastern Hospital, Chai Wan, Hong Kong.
authors.forename: H P
authors.initials: HP
authors.lastname: Shum
authors.affiliation: Department of Intensive Care, Pamela Youde Nethersole Eastern Hospital, Chai Wan, Hong Kong.
authors.forename: W W
authors.initials: WW
authors.lastname: Yan
authors.affiliation: Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong.
authors.forename: T M
authors.initials: TM
authors.lastname: Chan
mesh_terms: D058186:Acute Kidney Injury / Q000209:etiology / Q000628:therapy*; D001427:Bacterial Toxins / Q000302:isolation & purification; D006440:Hemofiltration / Q000379:methods*; D006801:Humans; D018836:Inflammation Mediators / Q000302:isolation & purification; D018805:Sepsis / Q000628:therapy*
chemical_list: D001427:Bacterial Toxins; D018836:Inflammation Mediators
keywords: Hemofiltration; Kidney diseases; Sepsis