title: Current Status and Future of Skin Substitutes for Chronic Wound Healing.
abstract: Chronic wounds, including diabetic ulcers, pressure ulcers, venous ulcers, and arterial insufficiency ulcers, are both difficult and expensive to treat. Conventional wound care may sometimes lead to suboptimal wound healing and significant morbidity and mortality for patients. The use of skin substitutes provides an alternative therapy showing superior efficacy and, in some cases, similar cost-effectiveness compared to traditional treatments. This review discusses the different types of currently available commercial skin substitutes for use in chronic wounds as well as the paucity of strong evidence supporting their use. It then delves into the limitations of these skin substitutes and examines the most recent research targeting these limitations.
authors.affiliation: 1 Faculty of Medicine, University of Toronto, Toronto, ON, Canada.
authors.forename: Mathew N
authors.initials: MN
authors.lastname: Nicholas
authors.affiliation: 2 Department of Dermatology, Women's College Hospital and Sunnybrook Health Sciences Centre, Toronto, ON, Canada.|3 Division of Dermatology, University of Toronto, Toronto, ON, Canada.
authors.forename: Jensen
authors.initials: J
authors.lastname: Yeung
mesh_terms: D062088:Acellular Dermis; D002908:Chronic Disease; D005109:Extracellular Matrix; D005347:Fibroblasts; D005544:Forecasting; D006801:Humans; D015603:Keratinocytes; D012883:Skin Ulcer / Q000628:therapy*; D017768:Skin, Artificial / Q000639:trends; D014945:Wound Healing
keywords: diabetic; foot ulcer; pressure ulcer; skin substitutes; tissue engineering; venous ulcer; wound healing