title: Association of the ADIPOQ Rs2241766 and Rs266729 Polymorphisms with Metabolic Syndrome in the Chinese Population: A Meta-analysis.
abstract: OBJECTIVE
  This meta-analysis was performed to summarize the association of the ADIPOQ rs2241766 and rs266729 polymorphisms with metabolic syndrome (MS) in the Chinese population.
  
  
  METHODS
  We searched for articles in MEDLINE via PubMed, EMBASE, HuGE Navigator, CNKI, and Wanfang databases and calculated odds ratios (ORs) with 95% confidence intervals (CIs) to determine the strength of associations in fixed- or random-effects models.
  
  
  RESULTS
  We included 21 articles in the meta-analysis: 17 reports of ADIPOQ rs2241766 with 3628 cases and 3000 controls and 8 of rs266729 with 2021 cases and 2226 controls. We found an increased risk of MS with the ADIPOQ rs2241766 polymorphism in some genetic models (allele model: OR=1.12, 95% CI: 1.03-1.21; dominant model: OR=1.15, 95% CI: 1.04-1.28; homozygote model: OR=1.22, 95% CI: 1.00-1.49) but no association with the ADIPOQ rs266729 polymorphism (allele model: OR=0.98, 95% CI: 0.82-1.17; dominant model: OR=0.90, 95% CI: 0.79-1.02; recessive model: OR=1.09, 95% CI: 0.85-1.39; homozygote model: OR=1.03, 95% CI: 0.80-1.33).
  
  
  CONCLUSIONS
  The results of this meta-analysis suggest an association between the ADIPOQ rs2241766 polymorphism and MS in the Chinese population. G allele of ADIPOQ rs2241766 increases the risk of MS. Better designed studies with different ethnic populations and larger sample sizes are needed for assessing the relationship between ADIPOQ rs2241766 and rs266729 polymorphisms and MS in the future.
authors.affiliation: Department of Preventive Medicine, Shenzhen University Health Sciences Center, Shenzhen 518060, Guangdong, China.
authors.forename: Jun Mei
authors.initials: JM
authors.lastname: Zhou
authors.affiliation: Department of Preventive Medicine, Shenzhen University Health Sciences Center, Shenzhen 518060, Guangdong, China.
authors.forename: Ming
authors.initials: M
authors.lastname: Zhang
authors.affiliation: School of Basic Medicine, Shenzhen University Health Sciences Center, Shenzhen 518060, Guangdong, China.
authors.forename: Shu
authors.initials: S
authors.lastname: Wang
authors.affiliation: Department of Epidemiology and Health Statistics, College of Public Health, Zhengzhou University, Zhengzhou 450003, Henan, China.
authors.forename: Bing Yuan
authors.initials: BY
authors.lastname: Wang
authors.affiliation: Department of Epidemiology and Health Statistics, College of Public Health, Zhengzhou University, Zhengzhou 450003, Henan, China.
authors.forename: Cheng Yi
authors.initials: CY
authors.lastname: Han
authors.affiliation: Department of Epidemiology and Health Statistics, College of Public Health, Zhengzhou University, Zhengzhou 450003, Henan, China.
authors.forename: Yong Cheng
authors.initials: YC
authors.lastname: Ren
authors.affiliation: Department of Epidemiology and Health Statistics, College of Public Health, Zhengzhou University, Zhengzhou 450003, Henan, China.
authors.forename: Lu
authors.initials: L
authors.lastname: Zhang
authors.affiliation: Department of Epidemiology and Health Statistics, College of Public Health, Zhengzhou University, Zhengzhou 450003, Henan, China.
authors.forename: Hong Yan
authors.initials: HY
authors.lastname: Zhang
authors.affiliation: Department of Epidemiology and Health Statistics, College of Public Health, Zhengzhou University, Zhengzhou 450003, Henan, China.
authors.forename: Xiang Yu
authors.initials: XY
authors.lastname: Yang
authors.affiliation: Department of Epidemiology and Health Statistics, College of Public Health, Zhengzhou University, Zhengzhou 450003, Henan, China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Zhao
authors.affiliation: Department of Preventive Medicine, Shenzhen University Health Sciences Center, Shenzhen 518060, Guangdong, China.
authors.forename: Dong Sheng
authors.initials: DS
authors.lastname: Hu
mesh_terms: D052242:Adiponectin / Q000235:genetics* / Q000378:metabolism*; D002681:China / Q000453:epidemiology; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D024821:Metabolic Syndrome / Q000453:epidemiology* / Q000235:genetics*; D011110:Polymorphism, Genetic; D012307:Risk Factors
chemical_list: C499918:ADIPOQ protein, human; D052242:Adiponectin
keywords: ADIPOQ; Meta-analysis; Metabolic syndrome; Polymorphisms