title: Comparing Volume Loss in Neuroanatomical Regions of Emotion versus Regions of Cognition in Healthy Aging.
abstract: Many emotional functions are relatively preserved in aging despite declines in several cognitive domains and physical health. High levels of happiness exist even among centenarians. To address the hypothesis of whether preservation of emotional function in healthy aging may relate to different rates of age-related volume loss across brain structures, we performed two volumetric analyses on structural magnetic resonance neuroimaging of a group of healthy aging research participants using Freesurfer version 5.1. Volumes selected as supporting cognition included bilateral midfrontal and lateral frontal gyri, lateral parietal and temporal cortex, and medial temporal lobes. Volumes supporting emotion included bilateral amygdala, rostral anterior cingulate, insula, orbitofrontal cortex, and nucleus accumbens. A cross-sectional analysis was performed using structural MRI scans from 258 subjects. We found no difference in proportional change between groups. A longitudinal mixed effects model was used to compare regional changes over time in a subset of 84 subjects. Again, there was no difference in proportional change over time. While our results suggest that aging does not collectively target cognitive brain regions more than emotional regions, subgroup analysis suggests relative preservation of the anterior cingulate cortex, with greater volume loss in the nucleus accumbens. Implications of these relative rates of age-related volume loss in healthy aging are discussed and merit further research.
authors.affiliation: Memory and Aging Center, Department of Neurology, University of California, 675 Nelson Rising Lane, Suite 190, San Francisco, California, 94158, United States of America.
authors.forename: Peter S
authors.identifier: http://orcid.org/0000-0003-1760-1286
authors.initials: PS
authors.lastname: Pressman
authors.affiliation: Memory and Aging Center, Department of Neurology, University of California, 675 Nelson Rising Lane, Suite 190, San Francisco, California, 94158, United States of America.
authors.forename: Yuliana
authors.initials: Y
authors.lastname: Noniyeva
authors.affiliation: Memory and Aging Center, Department of Neurology, University of California, 675 Nelson Rising Lane, Suite 190, San Francisco, California, 94158, United States of America.
authors.forename: Nick
authors.initials: N
authors.lastname: Bott
authors.affiliation: Memory and Aging Center, Department of Neurology, University of California, 675 Nelson Rising Lane, Suite 190, San Francisco, California, 94158, United States of America.
authors.forename: Shubir
authors.initials: S
authors.lastname: Dutt
authors.affiliation: Memory and Aging Center, Department of Neurology, University of California, 675 Nelson Rising Lane, Suite 190, San Francisco, California, 94158, United States of America.
authors.forename: Virginia
authors.initials: V
authors.lastname: Sturm
authors.affiliation: Memory and Aging Center, Department of Neurology, University of California, 675 Nelson Rising Lane, Suite 190, San Francisco, California, 94158, United States of America.
authors.forename: Bruce L
authors.initials: BL
authors.lastname: Miller
authors.affiliation: Memory and Aging Center, Department of Neurology, University of California, 675 Nelson Rising Lane, Suite 190, San Francisco, California, 94158, United States of America.
authors.forename: Joel H
authors.initials: JH
authors.lastname: Kramer
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000502:physiology*; D002540:Cerebral Cortex / Q000000981:diagnostic imaging / Q000502:physiology*; D003071:Cognition / Q000502:physiology*; D004644:Emotions / Q000502:physiology*; D005260:Female; D006240:Happiness; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009445:Neuroanatomy; D009929:Organ Size / Q000502:physiology