title: The continued use of sunscreen prevents the development of actinic keratosis in aged Japanese subjects.
abstract: It is well known that the trigger for actinic keratosis (AK) mainly depends on UV exposure. We evaluated the effects of long-term use of sunscreen on the histopathological and dermoscopic changes of AK in aged patients. Eighteen months use of sunscreen produced no change in the number of actinic keratoses or the advancement of histological grade. Although a significant decrease was not observed in the number of positive cells of p53, Ki-67 and COX-2 of the subjects who used sunscreen for 18 months, the downward tendencies of these proteins were observed. The continued use of sunscreen decreased the number of CD31-positive vessels significantly using the Chalkley method, and a significant improvement in scaling and vessel dots was found by dermoscopic study. Moreover, a relationship was found in the amount of sunscreen use and the number of actinic keratoses. Considering these results, it was thought that application of sunscreen reduces the risk of advancement of AK to higher grade AK and squamous cell carcinoma.
authors.affiliation: Department of Dermatology, Faculty of Medicine, Wakayama Medical University, Wakayama, Japan.
authors.forename: Kayo
authors.initials: K
authors.lastname: Kunimoto
authors.affiliation: Department of Dermatology, Faculty of Medicine, Wakayama Medical University, Wakayama, Japan.
authors.forename: Fukumi
authors.initials: F
authors.lastname: Furukawa
authors.affiliation: Department of Dermatology, Faculty of Medicine, Wakayama Medical University, Wakayama, Japan.
authors.forename: Mikiko
authors.initials: M
authors.lastname: Uede
authors.affiliation: Department of Dermatology, Faculty of Medicine, Wakayama Medical University, Wakayama, Japan.|Fundamental Research Laboratories, KOSÉ Corporation, Tokyo, Japan.
authors.forename: Makoto
authors.initials: M
authors.lastname: Mizuno
authors.affiliation: Department of Dermatology, Faculty of Medicine, Wakayama Medical University, Wakayama, Japan.|Department of Cosmetic Dermatology and Photomedicine, Faculty of Medicine, Wakayama Medical University, Wakayama, Japan.
authors.forename: Yuki
authors.initials: Y
authors.lastname: Yamamoto
mesh_terms: D000368:Aged; D044466:Asian People; D002294:Carcinoma, Squamous Cell / Q000517:prevention & control; D051546:Cyclooxygenase 2 / Q000378:metabolism; D046169:Dermoscopy; D018450:Disease Progression; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007564:Japan; D055623:Keratosis, Actinic / Q000378:metabolism / Q000473:pathology / Q000517:prevention & control*; D019394:Ki-67 Antigen / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D019408:Platelet Endothelial Cell Adhesion Molecule-1 / Q000378:metabolism; D012878:Skin Neoplasms / Q000517:prevention & control; D013473:Sunscreening Agents / Q000008:administration & dosage*; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism; D014466:Ultraviolet Rays / Q000009:adverse effects
chemical_list: D019394:Ki-67 Antigen; D019408:Platelet Endothelial Cell Adhesion Molecule-1; D013473:Sunscreening Agents; C495901:TP53 protein, human; D016159:Tumor Suppressor Protein p53; D051546:Cyclooxygenase 2; C496540:PTGS2 protein, human
keywords: Japanese; actinic keratosis; aged subjects; prevention; sunscreen