title: Synthesis of Substituted Furan/Pyrrole-3-carboxamides through a Tandem Nucleopalladation and Isocyanate Insertion.
abstract: Access to furanyl- and pyrrolyl-3-carboxamides from readily available 3-alkyne-1,2-diols and 1-amino-3-alkyn-2-ols using isocyanate as amido surrogate is demonstrated. The approach constitutes a successful unprecedented combination of heteropalladation and isocyanate insertion, a new avenue for novel amide bond constructions. The mechanism likely involves a 6-membered oxaaminopalladacycle as the key intermediate.
authors.forename: Manda
authors.initials: M
authors.lastname: Rajesh
authors.forename: Surendra
authors.initials: S
authors.lastname: Puri
authors.forename: Ruchir
authors.initials: R
authors.lastname: Kant
authors.affiliation: Academy of Scientific and Innovative Research , New Delhi 110001, India.
authors.forename: Maddi
authors.initials: M
authors.lastname: Sridhar Reddy