title: Post-exercise syncope: Wingate syncope test and visual-cognitive function.
abstract: Adequate cerebral perfusion is necessary to maintain consciousness in upright humans. Following maximal anaerobic exercise, cerebral perfusion can become compromised and result in syncope. It is unknown whether post-exercise reductions in cerebral perfusion can lead to visual-cognitive deficits prior to the onset of syncope, which would be of concern for emergency workers and warfighters, where critical decision making and intense physical activity are combined. Therefore, the purpose of this experiment was to determine if reductions in cerebral blood velocity, induced by maximal anaerobic exercise and head-up tilt, result in visual-cognitive deficits prior to the onset of syncope. Nineteen sedentary to recreationally active volunteers completed a symptom-limited 60° head-up tilt for 16 min before and up to 16 min after a 60 sec Wingate test. Blood velocity of the middle cerebral artery was measured using transcranial Doppler ultrasound and a visual decision-reaction time test was assessed, with independent analysis of peripheral and central visual field responses. Cerebral blood velocity was 12.7 ± 4.0% lower (mean ± SE; P < 0.05) after exercise compared to pre-exercise. This was associated with a 63 ± 29% increase (P < 0.05) in error rate for responses to cues provided to the peripheral visual field, without affecting central visual field error rates (P = 0.46) or decision-reaction times for either visual field. These data suggest that the reduction in cerebral blood velocity following maximal anaerobic exercise contributes to visual-cognitive deficits in the peripheral visual field without an apparent affect to the central visual field.
authors.affiliation: Department of Human Physiology, University of Oregon, Eugene, Oregon.
authors.forename: Dylan C
authors.initials: DC
authors.lastname: Sieck
authors.affiliation: Department of Human Physiology, University of Oregon, Eugene, Oregon.
authors.forename: Matthew R
authors.initials: MR
authors.lastname: Ely
authors.affiliation: Department of Human Physiology, University of Oregon, Eugene, Oregon.
authors.forename: Steven A
authors.initials: SA
authors.lastname: Romero
authors.affiliation: Department of Human Physiology, University of Oregon, Eugene, Oregon.
authors.forename: Meredith J
authors.initials: MJ
authors.lastname: Luttrell
authors.affiliation: Department of Human Physiology, University of Oregon, Eugene, Oregon.
authors.forename: Pedro M
authors.initials: PM
authors.lastname: Abdala
authors.affiliation: Department of Human Physiology, University of Oregon, Eugene, Oregon halliwil@uoregon.edu.
authors.forename: John R
authors.initials: JR
authors.lastname: Halliwill
mesh_terms: D000328:Adult; D001783:Blood Flow Velocity / Q000502:physiology*; D001921:Brain / Q000098:blood supply* / Q000000981:diagnostic imaging; D003071:Cognition / Q000145:classification / Q000502:physiology*; D015444:Exercise / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D020768:Middle Cerebral Artery / Q000503:physiopathology; D054971:Orthostatic Intolerance / Q000175:diagnosis / Q000209:etiology / Q000503:physiopathology; D057774:Post-Exercise Hypotension / Q000175:diagnosis* / Q000209:etiology / Q000503:physiopathology*; D011187:Posture / Q000502:physiology*; D011930:Reaction Time / Q000502:physiology*; D013575:Syncope / Q000209:etiology*; D018667:Tilt-Table Test / Q000379:methods; D017585:Ultrasonography, Doppler, Transcranial / Q000379:methods
keywords: Anaerobic exercise; cerebrovascular circulation; hypotension; orthostatic; orthostatic intolerance; post‐exercise hypotension; syncope; tilt‐table test; vasovagal