title: [Value of prostate volume, PSAD and F/T in the detection of prostate cancer in males with PSA 4-10 μg/L].
abstract: OBJECTIVE
  To evaluate the association of prostate volume, PSAD and F/T with prostate cancer detection rate in males with a total PSA of 4-10 μg/L.
  
  
  METHODS
  Clinical data of 196 patients who underwent prostate biopsy from November 2006 to September 2010 and with a PSA of 4-10 μg/L were retrospectively analyzed. The association of detection rate of prostate cancer with prostate volume, prostate specific antigen density PSAD) and free PSA/total PSA ratio (F/T) was analyzed by Spearman coefficient, receiver operating characteristic curve and logistic regression analysis.
  
  
  RESULTS
  The prostate volume, PSAD and F/T had a significant association with detection rate of prostate cancer (P<0.05 for all). The odd ratio was 0.96, 1.91 and 0.02, respectively. The area under curve (AUR) was 0.31, 0.66 and 0.63, respectively. The cancer detection rate was decreased along with the increase of prostate volume. When PSAD 0.15 ng·ml(-1)·ml(-1) was used as the cut-off value, the sensitivity, specificity, positive prediction rate and negative prediction rate was 72.3%, 51.1%, 42.3% and 21.2%, respectively. When the patients were divided by prostate volume into <19.9, 20-39.9, 40-59.9, 60-79.9 and >80 ml subgroups, the cancer detection rate of each subgroup was 50.0%, 45.6%, 30.8%, 15.4% and 5.6%, respectively.
  
  
  CONCLUSIONS
  In patients with a total PSA of 4-10 μg/L, the prostate cancer detection rate has a significant association with prostate volume, PSAD and F/T.
authors.affiliation: Department of Urology, Beijing Hospital of the Ministry of Health, Beijing 100000, China.
authors.forename: M
authors.initials: M
authors.lastname: Liu
authors.affiliation: Department of Urology, Beijing Hospital of the Ministry of Health, Beijing 100000, China.
authors.forename: H M
authors.initials: HM
authors.lastname: Hou
authors.affiliation: Department of Urology, Beijing Hospital of the Ministry of Health, Beijing 100000, China.
authors.forename: X
authors.initials: X
authors.lastname: Li
authors.affiliation: Department of Urology, Beijing Hospital of the Ministry of Health, Beijing 100000, China.
authors.forename: Y Q
authors.initials: YQ
authors.lastname: Zhang
authors.affiliation: Department of Urology, Beijing Hospital of the Ministry of Health, Beijing 100000, China.
authors.forename: B
authors.initials: B
authors.lastname: Wan
authors.affiliation: Department of Urology, Beijing Hospital of the Ministry of Health, Beijing 100000, China.
authors.forename: J Y
authors.initials: JY
authors.lastname: Wang
authors.affiliation: Department of Urology, Beijing Hospital of the Ministry of Health, Beijing 100000, China.
authors.forename: B
authors.initials: B
authors.lastname: Jin
mesh_terms: D019540:Area Under Curve; D001706:Biopsy; D006801:Humans; D008297:Male; D009929:Organ Size; D011467:Prostate / Q000473:pathology*; D017430:Prostate-Specific Antigen / Q000097:blood*; D011471:Prostatic Neoplasms / Q000097:blood* / Q000175:diagnosis / Q000473:pathology*; D012372:ROC Curve; D012044:Regression Analysis; D012189:Retrospective Studies; D012680:Sensitivity and Specificity
chemical_list: D017430:Prostate-Specific Antigen