title: HLA-DRB1 allele polymorphism and nasopharyngeal carcinoma risk: a meta-analysis.
abstract: The human leukocyte antigens (HLA) DRB1 polymorphism has been implicated in susceptibility to nasopharyngeal carcinoma (NPC). However, the results are inconsistent. The aim of this meta-analysis is to evaluate the association between the HLA-DRB1 polymorphisms and NPC risk. All eligible case-control studies published up to June 17, 2015 were identified by searching PubMed, Web of Science, CNKI, Wanfang, and Weipu databases. The NPC risk associated with the HLA-DRB1 polymorphism was estimated for each study by odds ratios (OR) together with its 95 % confidence interval (CI), respectively. Twelve studies with 1152 cases and 1600 controls were included. Overall, a significant positively association between the HLA-DRB1*03, *08, *09, and *10 alleles polymorphism and NPC risk were found (OR = 1.55, 95 % CI 1.30-1.86; OR = 1.44, 95 % CI 1.08-1.92; OR = 1.33, 95 % CI 1.06-1.67; OR = 1.82, 95 % CI 1.02-3.26, respectively), and the HLA-DRB1*01, *11, and *12 alleles were negatively associated with NPC risk (OR = 0.55, 95 % CI 0.39-0.78; OR = 0.62, 95 % CI 0.42-0.91; OR = 0.62, 95 % CI 0.47-0.81, respectively), but we failed to detect any association between other alleles and NPC risk. When stratified by ethnicity, similar results were observed among Asians for HLA-DRB1*03, *08, *09, *11, and *12 alleles and Tunisians for HLA-DRB1*01, *03, and *11 alleles; However, no significant association among Caucasians was observed. This meta-analysis suggests that the HLA-DRB1*03, *08, *09, and *10 alleles polymorphism contributed to the susceptibility of NPC, whereas HLA-DRB1*11 and *12 alleles polymorphism may be an important protective factor for NPC, especially of Asian populations.
authors.affiliation: Department of Otolaryngology, Liaocheng People's Hospital, 67 Dongchangxi Road, Liaocheng, 252000, Shandong, China.
authors.forename: Keqing
authors.initials: K
authors.lastname: Yao
authors.affiliation: Department of Otolaryngology, Liaocheng People's Hospital, 67 Dongchangxi Road, Liaocheng, 252000, Shandong, China. sdlcyangsj@163.com.
authors.forename: Shujuan
authors.initials: S
authors.lastname: Yang
authors.affiliation: Department of Pediatrics, The Affiliated Hospital of Chengde Medical University, Chengde, 067000, Hebei, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Shen
authors.affiliation: Department of Otolaryngology, Liaocheng People's Hospital, 67 Dongchangxi Road, Liaocheng, 252000, Shandong, China.
authors.forename: Ran
authors.initials: R
authors.lastname: Zhang
authors.affiliation: Department of Otolaryngology, Liaocheng People's Hospital, 67 Dongchangxi Road, Liaocheng, 252000, Shandong, China.
authors.forename: Lianqing
authors.initials: L
authors.lastname: Li
mesh_terms: D002277:Carcinoma; D005006:Ethnicity / Q000235:genetics; D020022:Genetic Predisposition to Disease; D059811:HLA-DRB1 Chains / Q000235:genetics*; D006801:Humans; D000077274:Nasopharyngeal Carcinoma; D009303:Nasopharyngeal Neoplasms / Q000208:ethnology / Q000235:genetics / Q000473:pathology; D011110:Polymorphism, Genetic; D065840:Protective Factors; D018570:Risk Assessment
chemical_list: D059811:HLA-DRB1 Chains
keywords: HLA-DR; Meta-analysis; Nasopharyngeal carcinoma; Polymorphism