title: Heterogeneous Phase Transfer Catalysis in Solid Phase Syntheses of Anth-Cyclic Tetrapeptides.
abstract: This study features solid phase syntheses of cyclic tetrapeptides containing anthranilic acid (Anth) on relatively inexpensive resins derived from polystyrene. It proved to be difficult to hydrolyze a supported Anth-methyl ester unless a phase transfer catalyst was added to facilitate transport of hydroxide into the swollen hydrophobic gel state of the resin. We suggest this may be an under-appreciated strategy for improving syntheses on polystyrene supports.
authors.affiliation: Department of Chemistry, Texas A & M University , Box 30012, College Station, Texas 77842, United States.
authors.forename: Dongyue
authors.initials: D
authors.lastname: Xin
authors.affiliation: Department of Applied Biology and Chemical Technology and the State Key Laboratory of Chirosciences, The Hong Kong Polytechnic University , Hunghom, Kowloon, Hong Kong, P. R. China.
authors.forename: Jian
authors.initials: J
authors.lastname: Yuan
authors.affiliation: Department of Applied Biology and Chemical Technology and the State Key Laboratory of Chirosciences, The Hong Kong Polytechnic University , Hunghom, Kowloon, Hong Kong, P. R. China.
authors.forename: Kwok-Yin
authors.initials: KY
authors.lastname: Wong
authors.affiliation: Department of Chemistry, Texas A & M University , Box 30012, College Station, Texas 77842, United States.
authors.forename: Kevin
authors.initials: K
authors.lastname: Burgess