title: A new phase modulated binomial-like selective-inversion sequence for solvent signal suppression in NMR.
abstract: A new 8-pulse Phase Modulated binomial-like selective inversion pulse sequence, dubbed '8PM', was developed by optimizing the nutation and phase angles of the constituent radio-frequency pulses so that the inversion profile resembled a target profile. Suppression profiles were obtained for both the 8PM and W5 based excitation sculpting sequences with equal inter-pulse delays. Significant distortions were observed in both profiles because of the offset effect of the radio frequency pulses. These distortions were successfully reduced by adjusting the inter-pulse delays. With adjusted inter-pulse delays, the 8PM and W5 based excitation sculpting sequences were tested on an aqueous lysozyme solution. The 8 PM based sequence provided higher suppression selectivity than the W5 based sequence. Two-dimensional nuclear Overhauser effect spectroscopy experiments were also performed on the lysozyme sample with 8PM and W5 based water signal suppression. The 8PM based suppression provided a spectrum with significantly increased (~ doubled) cross-peak intensity around the suppressed water resonance compared to the W5 based suppression. Copyright © 2016 John Wiley & Sons, Ltd.
authors.affiliation: Nanoscale Organisation and Dynamics Group, School of Science and Health, Western Sydney University, Penrith, NSW, Australia.
authors.forename: Johnny
authors.initials: J
authors.lastname: Chen
authors.affiliation: Nanoscale Organisation and Dynamics Group, School of Science and Health, Western Sydney University, Penrith, NSW, Australia.
authors.forename: Gang
authors.initials: G
authors.lastname: Zheng
authors.affiliation: Nanoscale Organisation and Dynamics Group, School of Science and Health, Western Sydney University, Penrith, NSW, Australia.
authors.forename: William S
authors.identifier: http://orcid.org/0000-0002-8549-4665
authors.initials: WS
authors.lastname: Price
mesh_terms: D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D008956:Models, Chemical; D055585:Physical Phenomena; D011846:Radio Waves; D012815:Signal Processing, Computer-Assisted; D012997:Solvents / Q000737:chemistry*; D014867:Water
chemical_list: D012997:Solvents; D014867:Water
keywords: NMR; binomial; binomial-like; excitation sculpting; selective inversion; solvent signal suppression; water signal suppression