title: Entropic Phase Transitions with Stable Twisted Intermediates of Bio-Inspired Self-Assembly.
abstract: Controlling the hierarchical process and capturing the intermediate stage underlying bio-inspired self-assembly are pivotal for understanding their aggregation mechanism and exploring possible applications. Here, the self-assembly of a designed minimal lipopeptide was characterized, showing it to initially self-assemble to narrow nanotwists, which then ripen to wide nanotwists, and finally transit to hollow nanotubes. The supramolecular phase transitions were revealed to be driven by entropic hydrophobic interactions, rather than by the common mechanism of enthalpy-related contributions. The transformation dynamics were sufficiently slow to enable detection and characterization of each stage, thus inducing the stable and extensive distributions of twisted intermediates. The findings allow an in-depth understanding of the hierarchical self-association of bio-inspired building blocks and provide a new approach for the preparation of superstructures of unique morphologies.
authors.affiliation: Department of Molecular Microbiology and Biotechnology, George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv, 6997801, Israel.
authors.forename: Kai
authors.identifier: http://orcid.org/0000-0003-3899-5181
authors.initials: K
authors.lastname: Tao
authors.affiliation: Department of Molecular Microbiology and Biotechnology, George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv, 6997801, Israel.
authors.forename: Aviad
authors.initials: A
authors.lastname: Levin
authors.affiliation: School of Physics and Astronomy, Faculty of Exact Sciences, Tel Aviv University, Tel Aviv, 6997801, Israel.
authors.forename: Guy
authors.initials: G
authors.lastname: Jacoby
authors.affiliation: School of Physics and Astronomy, Faculty of Exact Sciences, Tel Aviv University, Tel Aviv, 6997801, Israel.
authors.forename: Roy
authors.initials: R
authors.lastname: Beck
authors.affiliation: Department of Molecular Microbiology and Biotechnology, George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv, 6997801, Israel. ehudg@post.tau.ac.il.|Department of Materials Science and Engineering, Iby and Aladar Fleischman Faculty of Engineering, Tel Aviv University, Tel Aviv, 6997801, Israel. ehudg@post.tau.ac.il.
authors.forename: Ehud
authors.initials: E
authors.lastname: Gazit
keywords: entropy-driven ripening; lipopeptide; nanotubes; nanotwists; self-assembly