title: Is Risk of Artificial Urethral Sphincter Cuff Erosion Higher in Patients with Penile Prosthesis?
abstract: Frequently encountered morbidities after prostatectomy include stress urinary incontinence and erectile dysfunction. Patients with severe disease may undergo placement of both a penile prosthesis (PP) and an artificial urethral sphincter (AUS).
  
  
  
  We hypothesized that concomitant PP may promote AUS cuff erosion by impaired corporal blood flow and/or direct pressure on the cuff. The aim of this study was to compare the rate of AUS cuff erosion in patients with and without a PP.
  
  
  
  We reviewed 366 AUS operations at our tertiary center between 2007 and 2015 with a mean follow-up of 41 months (range 6-104). Included in the analysis were first-time AUS cuff erosions. Patients with recurrent erosions, AUS revisions, and iatrogenic erosions were excluded. In a separate analysis, we analyzed AUS explantations for all causes. Cohorts were compared by demographic information, preoperative characteristics, and rates of erosion and explantation.
  
  
  
  Erosion confirmed by cystourethroscopy and explantation of the AUS for all causes.
  
  
  
  Among 366 AUS surgeries at a mean follow-up of 41 months, there were 248 (67.8%) AUS alone cases compared to 118 (32.2%) AUS and PP cases (AUS/PP). Sixty-two patients met exclusion criteria for first-time cuff erosion. Among 304 evaluable AUS patients, we found a significantly higher rate of erosion in the AUS/PP group (11/95, 11.6%) compared to the AUS alone group (9/209, 4.3%, P = .037). When examining explantations for all causes in the entire cohort (n = 366), we observed a significantly higher rate of device removal, (20/118, 17%) in the AUS/PP group compared to the AUS group (23/248, 9.2%, P = .044).
  
  
  
  AUS/PP patients appear to have a higher risk of AUS cuff erosion and explantation compared to men with AUS alone.
authors.affiliation: Department of Urology, University of Texas Southwestern, Dallas, TX, USA.
authors.forename: Varun
authors.initials: V
authors.lastname: Sundaram
authors.affiliation: Department of Urology, University of Texas Southwestern, Dallas, TX, USA.
authors.forename: Billy H
authors.initials: BH
authors.lastname: Cordon
authors.affiliation: Department of Urology, University of Texas Southwestern, Dallas, TX, USA.
authors.forename: Matthias D
authors.initials: MD
authors.lastname: Hofer
authors.affiliation: Department of Urology, University of Texas Southwestern, Dallas, TX, USA. Electronic address: allen.morey@utsouthwestern.edu.
authors.forename: Allen F
authors.initials: AF
authors.lastname: Morey
mesh_terms: D000368:Aged; D020878:Device Removal / Q000009:adverse effects; D007172:Erectile Dysfunction / Q000209:etiology*; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D019935:Penile Implantation / Q000009:adverse effects*; D015917:Penile Prosthesis / Q000009:adverse effects*; D011468:Prostatectomy / Q000009:adverse effects; D011475:Prosthesis Failure / Q000209:etiology*; D012189:Retrospective Studies; D012306:Risk; D014521:Urethra / Q000601:surgery; D014546:Urinary Catheterization / Q000009:adverse effects; D016741:Urinary Sphincter, Artificial / Q000009:adverse effects*
keywords: Artificial Urethral Sphincter; Erosion; Penile Prosthesis; Stress Urinary Incontinence