title: Intermolecular Structural Change for Thermoswitchable Polymeric Photosensitizer.
abstract: We developed a thermoswitchable polymeric photosensitizer (T-PPS) by conjugating PS (Pheophorbide-a, PPb-a) to a temperature-responsive polymer backbone of biocompatible hydroxypropyl cellulose. Self-quenched PS molecules linked in close proximity by π-π stacking in T-PPS were easily transited to an active monomeric state by the temperature-induced phase transition of polymer backbones. The temperature-responsive intermolecular interaction changes of PS molecules in T-PPS were demonstrated in synchrotron small-angle X-ray scattering and UV-vis spectrophotometer analysis. The T-PPS allowed switchable activation and synergistically enhanced cancer cell killing effect at the hyperthermia temperature (45 °C). Our developed T-PPS has the considerable potential not only as a new class of photomedicine in clinics but also as a biosensor based on temperature responsiveness.
authors.forename: Wooram
authors.initials: W
authors.lastname: Park
authors.affiliation: Center for Photomedicine, Department of Biotechnology, The Catholic University of Korea , Bucheon-si, Gyeonggi-do 14662, Republic of Korea.
authors.forename: Sin-Jung
authors.initials: SJ
authors.lastname: Park
authors.forename: Soojeong
authors.initials: S
authors.lastname: Cho
authors.affiliation: Center for Photomedicine, Department of Biotechnology, The Catholic University of Korea , Bucheon-si, Gyeonggi-do 14662, Republic of Korea.
authors.forename: Heejun
authors.initials: H
authors.lastname: Shin
authors.affiliation: Center for Photomedicine, Department of Biotechnology, The Catholic University of Korea , Bucheon-si, Gyeonggi-do 14662, Republic of Korea.
authors.forename: Young-Seok
authors.initials: YS
authors.lastname: Jung
authors.affiliation: X-ray Science Division, Argonne National Laboratory , Argonne, Illinois 60439, United States.
authors.forename: Byeongdu
authors.initials: B
authors.lastname: Lee
authors.affiliation: Center for Photomedicine, Department of Biotechnology, The Catholic University of Korea , Bucheon-si, Gyeonggi-do 14662, Republic of Korea.
authors.forename: Kun
authors.initials: K
authors.lastname: Na
authors.forename: Dong-Hyun
authors.initials: DH
authors.lastname: Kim