title: Translation in Organelles of Apicomplexan Parasites.
abstract: The protein translation machineries of the apicoplast and mitochondrion-the two actively translating organelles of apicomplexan parasites-have potential sites for drug intervention against diseases caused by these organisms. Work in the past few years, particularly on Plasmodium falciparum and Toxoplasma gondii, has shown that a reduced machinery of enzymes and factors is sufficient for organellar translation, which is also supported by components shared with the cytosolic translation system. This interplay between eukaryotic and prokaryotic-like components for mRNA translation in organelles is reviewed here. We also discuss functional and structural aspects of factors mediating initiation, elongation, and termination of polypeptides, and recycling of the reduced ribosomes of the apicoplast and mitochondrion.
authors.affiliation: Division of Molecular and Structural Biology, CSIR-Central Drug Research Institute, Lucknow, India. Electronic address: saman.habib@gmail.com.
authors.forename: Saman
authors.initials: S
authors.lastname: Habib
authors.affiliation: Division of Molecular and Structural Biology, CSIR-Central Drug Research Institute, Lucknow, India.
authors.forename: Suniti
authors.initials: S
authors.lastname: Vaishya
authors.affiliation: Division of Molecular and Structural Biology, CSIR-Central Drug Research Institute, Lucknow, India.
authors.forename: Kirti
authors.initials: K
authors.lastname: Gupta
mesh_terms: D000818:Animals; D016782:Apicomplexa / Q000235:genetics*; D063546:Apicoplasts / Q000235:genetics*; D016503:Drug Delivery Systems; D006801:Humans; D008928:Mitochondria / Q000235:genetics*; D014176:Protein Biosynthesis; D011528:Protozoan Infections / Q000188:drug therapy / Q000469:parasitology; D016053:RNA, Protozoan / Q000235:genetics
chemical_list: D016053:RNA, Protozoan