title: Composition of the Leaf Essential Oil of Phoebe formosana from Taiwan and its in vitro Cytotoxic, Antibacterial, and Antifungal Activities.
abstract: The essential oil from the leaves of Phoebe formosana from Taiwan was isolated using hydrodistillation in a Clevenger-type apparatus, and characterized by GC-FID and GC-MS. Seventy-one compounds were identified, representing 100% of the oil. The main components identified were a-humulene (16.8%), τ-cadinol (8.9%), α-pinene (8.4%), α-cadinol (8.1%), β-caryophyllene (8.0%), β-phellandrene (6.0%), and β-eudesmol (5.8%). The oil exhibited cytotoxic activity against human lung, liver and oral cancer cells. The active compounds were β-caryophyllene, α-humulene, τ-cadinol, β-eudesmol, and α-cadinol. The antibacterial activity of the oil was tested by the disc diffusion and micro-broth dilution methods against eight bacterial species. The oil exhibited moderate growth suppression against Gram-positive bacteria with inhibition zones of 28 to 36 mm, and MIC values of 250 to 375 μg/mL. The active antibacterial compounds were determined to be τ-cadinol, β-eudesmol, and α-cadinol. The leaf oil displayed excellent antifungal activity with the active compounds determined as α-cadinol, β-eudesmol, τ-cadinol, α-humulene, and β-caryophyllene.
authors.forename: Yu-Chang
authors.initials: YC
authors.lastname: Su
authors.forename: Chen-Lung
authors.initials: CL
authors.lastname: Ho
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology; D000935:Antifungal Agents / Q000737:chemistry* / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects / Q000254:growth & development; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D005658:Fungi / Q000187:drug effects / Q000254:growth & development; D006801:Humans; D019770:Lauraceae / Q000737:chemistry*; D008826:Microbial Sensitivity Tests; D009822:Oils, Volatile / Q000737:chemistry* / Q000494:pharmacology; D010936:Plant Extracts / Q000737:chemistry* / Q000494:pharmacology; D018515:Plant Leaves / Q000737:chemistry; D013624:Taiwan
chemical_list: D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D009822:Oils, Volatile; D010936:Plant Extracts