title: Enantioselective Generation of Adjacent Stereocenters in a Copper-Catalyzed Three-Component Coupling of Imines, Allenes, and Diboranes.
abstract: A highly enantio- and diastereoselective copper-catalyzed three-component coupling affords the first general synthesis of homoallylic amines bearing adjacent stereocenters from achiral starting materials. The method utilizes a commercially available NHC ligand and copper source, operates at ambient temperature, couples readily available simple imines, allenes, and diboranes, and yields high-value homoallylic amines that exhibit versatile amino, alkenyl, and boryl units.
authors.affiliation: School of Chemistry, University of Manchester, Oxford Rd, Manchester, M13 9PL, UK.
authors.forename: Kay
authors.initials: K
authors.lastname: Yeung
authors.affiliation: School of Chemistry, University of Manchester, Oxford Rd, Manchester, M13 9PL, UK.
authors.forename: Rebecca E
authors.initials: RE
authors.lastname: Ruscoe
authors.affiliation: School of Chemistry, University of Manchester, Oxford Rd, Manchester, M13 9PL, UK.
authors.forename: James
authors.initials: J
authors.lastname: Rae
authors.affiliation: School of Chemistry, University of Manchester, Oxford Rd, Manchester, M13 9PL, UK.
authors.forename: Alexander P
authors.initials: AP
authors.lastname: Pulis
authors.affiliation: School of Chemistry, University of Manchester, Oxford Rd, Manchester, M13 9PL, UK. david.j.procter@manchester.ac.uk.
authors.forename: David J
authors.initials: DJ
authors.lastname: Procter
keywords: amines; asymmetric catalysis; boron; copper; multicomponent reactions