title: The TRAIL to acne pathogenesis: let's focus on death pathways.
abstract: This hypothesis presents acne as a PI3K-Akt-mTORC1-driven pro-survival disease of the sebaceous follicle with impaired TRAIL-mediated death signalling. It is predicted that anti-acne agents such as isotretinoin enhance death signalling and thereby readjust the disturbed balance of pro-survival and death signalling of the sebaceous follicle in acne vulgaris. For this purpose, immortalized sebocyte cultures are regarded as inapproproate models to study the key features of acne pathogenesis.
authors.affiliation: Department of Dermatology, Environmental Medicine and Health Theory, University of Osnabrück, Osnabrück, Germany.
authors.forename: Bodo C
authors.initials: BC
authors.lastname: Melnik
mesh_terms: D000152:Acne Vulgaris / Q000378:metabolism*; D017209:Apoptosis; D053446:CASP8 and FADD-Like Apoptosis Regulating Protein / Q000378:metabolism; D002470:Cell Survival; D006801:Humans; D000076222:Mechanistic Target of Rapamycin Complex 1 / Q000378:metabolism; D058539:Phosphatidylinositol 3-Kinase / Q000378:metabolism; D051057:Proto-Oncogene Proteins c-akt / Q000378:metabolism; D015398:Signal Transduction; D053221:TNF-Related Apoptosis-Inducing Ligand / Q000378:metabolism*; D016212:Transforming Growth Factor beta / Q000378:metabolism; D014212:Tretinoin / Q000494:pharmacology
chemical_list: D053446:CASP8 and FADD-Like Apoptosis Regulating Protein; D053221:TNF-Related Apoptosis-Inducing Ligand; C505653:TNFSF10 protein, human; D016212:Transforming Growth Factor beta; D014212:Tretinoin; D058539:Phosphatidylinositol 3-Kinase; D000076222:Mechanistic Target of Rapamycin Complex 1; D051057:Proto-Oncogene Proteins c-akt
keywords: FoxOs; acne; apoptosis; c-FLIP; death signalling; tumor necrosis factor-related apoptosis-inducing ligand