title: The Role of Preoperative Magnetic Resonance Imaging in the Assessment and Surgical Treatment of Interval and Screen-Detected Breast Cancer in Older Women.
abstract: We describe the relationship between preoperative magnetic resonance imaging (MRI) and the utilization of additional imaging, biopsy, and primary surgical treatment for subgroups of women with interval versus screen-detected breast cancer. We determined the proportion of women receiving additional breast imaging or biopsy and type of primary surgical treatment, stratified by use of preoperative MRI, separately for both groups. Using Breast Cancer Surveillance Consortium (BCSC) data, we identified a cohort of women age 66 and older with an interval or screen-detected breast cancer diagnosis between 2005 and 2010. Using logistic regression, we explored associations between primary surgical treatment type and preoperative MRI use for interval and screen-detected cancers. There were 204 women with an interval cancer and 1,254 with a screen-detected cancer. The interval cancer group was more likely to receive preoperative MRI (21% versus 13%). In both groups, women receiving MRI were more likely to receive additional imaging and/or biopsy. Receipt of MRI was not associated with increased odds of mastectomy (OR = 0.99, 95% CI: 0.67-1.50), while interval cancer diagnosis was associated with significantly higher odds of mastectomy (OR = 1.64, 95% CI: 1.11-2.42). Older women with interval cancer were more likely than women with a screen-detected cancer to have preoperative MRI, however, those with an interval cancer had 64% higher odds of mastectomy regardless of receipt of MRI. Given women with interval cancer are reported to have a worse prognosis, more research is needed to understand effectiveness of imaging modalities and treatment consequences within this group.
authors.affiliation: Department of Biomedical Data Sciences, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire.
authors.forename: Martha E
authors.initials: ME
authors.lastname: Goodrich
authors.affiliation: Department of Biomedical Data Sciences, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire.
authors.forename: Julie
authors.initials: J
authors.lastname: Weiss
authors.affiliation: Department of Biomedical Data Sciences, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire.|The Dartmouth Institute for Health Policy and Clinical Practice and Norris Cotton Cancer Center, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire.
authors.forename: Tracy
authors.initials: T
authors.lastname: Onega
authors.affiliation: Group Health Research Institute, Seattle, Washington.
authors.forename: Steve L
authors.initials: SL
authors.lastname: Balch
authors.affiliation: Group Health Research Institute, Seattle, Washington.
authors.forename: Diana S M
authors.initials: DS
authors.lastname: Buist
authors.affiliation: Departments of Medicine and Epidemiology and Biostatistics, University of California at San Francisco, San Francisco, California.|General Internal Medicine Section, Department of Veterans Affairs, University of California at San Francisco, San Francisco, California.
authors.forename: Karla
authors.initials: K
authors.lastname: Kerlikowske
authors.affiliation: Department of Radiology, The University of North Carolina, Chapel Hill, North Carolina.
authors.forename: Louise M
authors.initials: LM
authors.lastname: Henderson
authors.affiliation: Group Health Research Institute, Seattle, Washington.|Department of Biostatistics, University of Pennsylvania, Philadelphia, Pennsylvania.
authors.forename: Rebecca A
authors.initials: RA
authors.lastname: Hubbard
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001943:Breast Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology / Q000601:surgery*; D055088:Early Detection of Cancer / Q000379:methods; D005260:Female; D006801:Humans; D016015:Logistic Models; D008279:Magnetic Resonance Imaging / Q000379:methods / Q000706:statistics & numerical data*; D008403:Mass Screening / Q000706:statistics & numerical data; D008408:Mastectomy; D015412:Mastectomy, Segmental; D011300:Preoperative Care
keywords: breast cancer; breast surgery; interval breast cancer; preoperative MRI