title: The miR-449b polymorphism, rs10061133 A>G, is associated with premature ovarian insufficiency.
abstract: To determine if the miR-449b polymorphism, rs10061133 A>G, is associated with premature ovarian insufficiency (POI) pathogenesis.
  
  
  
  From January 2011 to December 2014, a total of 148 individuals with POI and 225 age-matched controls were collected from the Center for Reproductive Medicine, 1st Affiliated Hospital of Anhui Medical University (Hefei, China). Genotyping of miR-449b rs1006113 was performed using matrix-assisted laser desorption ionization time-of-flight-based mass spectrometry.
  
  
  
  Rs10061133 A>G is a highly conserved SNP locus in the mature area of miR-449b. Association analysis shows that the rs10061133 AA genotype is a risk factor for POI.
  
  
  
  Our study provides the first evidence that the miR-449b rs10061133 AA genotype is associated with POI risk.
authors.affiliation: 1Center for Reproductive Medicine, Department of Obstetrics and Gynecology, The First Affiliated Hospital of Anhui Medical University, Hefei, China2National Research Institute for Family Planning, Beijing, China3College of Basic Medicine, Capital University of Medical Sciences, Beijing, China.
authors.forename: Hong
authors.initials: H
authors.lastname: Pan
authors.forename: Beili
authors.initials: B
authors.lastname: Chen
authors.forename: Jing
authors.initials: J
authors.lastname: Wang
authors.forename: Xi
authors.initials: X
authors.lastname: Wang
authors.forename: Ping
authors.initials: P
authors.lastname: Hu
authors.forename: Shinan
authors.initials: S
authors.lastname: Wu
authors.forename: Yunyun
authors.initials: Y
authors.lastname: Liu
authors.forename: Zuying
authors.initials: Z
authors.lastname: Xu
authors.forename: Wei
authors.initials: W
authors.lastname: Zhang
authors.forename: Binbin
authors.initials: B
authors.lastname: Wang
authors.forename: Yunxia
authors.initials: Y
authors.lastname: Cao
mesh_terms: D000328:Adult; D044466:Asian People / Q000235:genetics*; D016022:Case-Control Studies; D002681:China; D005260:Female; D056726:Genetic Association Studies; D005838:Genotype; D006801:Humans; D035683:MicroRNAs / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D016649:Primary Ovarian Insufficiency / Q000235:genetics*; D012307:Risk Factors
chemical_list: C544530:MIRN449 microRNA, human; D035683:MicroRNAs