title: Self-rated health and cancer risk - a prospective cohort study among Danish women.
abstract: BACKGROUND
  Self-rated health (SRH) has been shown to be a strong predictor of mortality from a number of major chronic diseases, however, the association with cancer remains unclear. The aim of this study was to investigate a possible association between change in SRH and cancer incidence.
  
  
  METHODS
  SRH and information on lifestyle and other risk factors were obtained for 13-636 women in the Danish Nurse Cohort. Cancers that developed during 12 years of follow-up were identified in the National Patient Registry. An association between SRH and cancer was examined in a Cox proportional hazards model with adjustment for age, smoking, alcohol, marital status, physical activity, body mass index and estrogen replacement therapy.
  
  
  RESULTS
  No significant association was found between SRH and overall cancer incidence in the age-adjusted Cox proportional hazards model (1.04; 95% CI 0.93-1.16), even after adjustment for potential confounding factors (HR 1.08; 95% CI 0.96-1.21). Likewise, there was no significant association between SRH and breast cancer (HR 1.09; 95% CI 0.89-1.33), lung cancer (HR 1.03; 95% CI 0.71-1.49) or colon cancer (HR 1.08; 95% CI 0.75-1.54).
  
  
  CONCLUSIONS
  SRH is not significantly associated with the incidence of all cancers or breast, lung or colon cancer among Danish female nurses. Women who reported a decrease in SRH between 1993 and 1999 had the same risk for cancer as those who reported unchanged or improved SRH.
authors.affiliation: a Rigshospitalet , Glostrup , Denmark.
authors.forename: Ida Kristiane
authors.initials: IK
authors.lastname: Roelsgaard
authors.affiliation: b Rigshospitalet , Copenhagen , Denmark.
authors.forename: Anne Marie
authors.initials: AM
authors.lastname: Olesen
authors.affiliation: b Rigshospitalet , Copenhagen , Denmark.
authors.forename: Mette Kildevæld
authors.initials: MK
authors.lastname: Simonsen
authors.affiliation: b Rigshospitalet , Copenhagen , Denmark.|c The Danish Cancer Society Research Centre , Copenhagen , Denmark.
authors.forename: Christoffer
authors.initials: C
authors.lastname: Johansen
mesh_terms: D000367:Age Factors; D000368:Aged; D003718:Denmark / Q000453:epidemiology; D005260:Female; D005500:Follow-Up Studies; D006306:Health Surveys / Q000379:methods*; D006801:Humans; D015994:Incidence; D008875:Middle Aged; D009369:Neoplasms / Q000453:epidemiology*; D011446:Prospective Studies; D012042:Registries / Q000706:statistics & numerical data*; D012307:Risk Factors; D057566:Self Report; D012959:Socioeconomic Factors