title: Prognosis of anterior cruciate ligament reconstruction: a data-driven approach.
abstract: Individuals who suffer anterior cruciate ligament (ACL) injury are at higher risk of developing knee osteoarthritis (OA) and almost 50% display symptoms 10-20 years post injury.Anterior cruciate ligament reconstruction(ACLR)often does not protect against knee OA development. Accordingly, a multi-scale formulation for data-driven prognosis (DDP) of post-ACLR is developed. Unlike traditional predictive strategies that require controlled off-line measurements or 'training' for determination of constitutive parameters to derive the transitional statistics, the proposed DDP algorithm relies solely onin situmeasurements. The proposed DDP scheme is capable of predicting onset of instabilities. As the need for off-line testing (or training) is obviated, it can be easily implemented for ACLR, where such controlleda prioritesting is almost impossible to conduct. The DDP algorithm facilitates hierarchical handling of the large dataset and can assess the state of recovery in post-ACLR conditions based on data collected from stair ascent and descent exercises of subjects. The DDP algorithm identifies inefficient knee varus motion and knee rotation as primary difficulties experienced by some of the post-ACLR population. In such cases, levels of energy dissipation rate at the knee, and its fluctuation may be used as measures for assessing progress after ACL reconstruction.
authors.affiliation: Department of Mechanical Engineering , Iowa State University , Ames, IA, USA.
authors.forename: Abhijit
authors.initials: A
authors.lastname: Chandra
authors.affiliation: Computer Science and Human Computer Interaction , Iowa State University , Ames, IA, USA.
authors.forename: Oliva
authors.initials: O
authors.lastname: Kar
authors.affiliation: Department of Mechanical Engineering , Iowa State University , Ames, IA, USA.
authors.forename: Kuan-Chuen
authors.initials: KC
authors.lastname: Wu
authors.affiliation: Centre for Health, Exercise and Sports Medicine, Department of Physiotherapy , School of Health Sciences, The University of Melbourne , Melbourne, VIC 3010, Australia.
authors.forename: Michelle
authors.initials: M
authors.lastname: Hall
authors.affiliation: Department of Kinesiology , Iowa State University , Ames, IA, USA.
authors.forename: Jason
authors.initials: J
authors.lastname: Gillette
keywords: anterior cruciate ligament reconstruction; data driven; energy dissipation rate; multi-scale; prognosis