title: Ru(II)/Organo Relay Catalytic Three-Component Reaction of 3-Diazooxindoles, Amines, and Nitroalkene: Formal Synthesis of (-)-Psychotrimine.
abstract: A highly enantioselective carbenoid-associated N-H functionalization/Michael addition cascade reaction is developed by virtue of Ru(II)/chiral organo bifunctional catalyst relay catalysis. In this way, a variety of optically pure 3-amino-3-alkyloxindoles can be easily achieved. Moreover, on the basis of this metal/organo relay catalytic three-component protocol, a key intermediate for the formal synthesis of (-)-psychotrimine could be obtained in six steps with 25% overall yield.
authors.affiliation: Hefei National Laboratory for Physical Sciences at the Microscale and Department of Chemistry, University of Science and Technology of China , Hefei 230026, China.
authors.forename: Xiao-Lei
authors.initials: XL
authors.lastname: Lian
authors.affiliation: Hefei National Laboratory for Physical Sciences at the Microscale and Department of Chemistry, University of Science and Technology of China , Hefei 230026, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Meng
authors.affiliation: Hefei National Laboratory for Physical Sciences at the Microscale and Department of Chemistry, University of Science and Technology of China , Hefei 230026, China.
authors.forename: Zhi-Yong
authors.initials: ZY
authors.lastname: Han