title: Papillary adnexal neoplasm (aggressive digital papillary adenocarcinoma) on the ankle of a 15-year-old girl: case report and review of literature from a pediatric perspective.
abstract: Digital papillary adenocarcinoma is a rare malignant tumor of the sweat glands, most commonly encountered in adult males. Only few pediatric cases have been reported, with an apparent predominance of females and none on the ankle. We report a case of a 15-year-old girl with a slowly growing, non-tender mass on the right ankle presenting with difficulty in walking; clinically believed to be a keloid. Excision of the mass revealed a glandular neoplasm with largely eccrine and focally apocrine differentiation. Histologic features do not reliably predict biologic behavior. Because of the existing confusion over the nomenclature, we propose that such tumors be called 'papillary adnexal neoplasms of distal extremities'.
authors.affiliation: Department of Pathology and Immunology, Texas Children's Hospital and Baylor College of Medicine, Houston, TX, USA.
authors.forename: Hao
authors.initials: H
authors.lastname: Wu
authors.affiliation: Division of Pediatric Surgery, Texas Children's Hospital and Baylor College of Medicine, Clinical Care Center, Houston, TX, USA.
authors.forename: Ashwin
authors.initials: A
authors.lastname: Pimpalwar
authors.affiliation: Department of Pathology and Immunology, Baylor College of Medicine, Houston, TX, USA.
authors.forename: Hafeez
authors.initials: H
authors.lastname: Diwan
authors.affiliation: Department of Pathology and Immunology, Texas Children's Hospital and Baylor College of Medicine, Houston, TX, USA.
authors.forename: Kalyani R
authors.initials: KR
authors.lastname: Patel
mesh_terms: D000231:Adenocarcinoma, Papillary / Q000473:pathology*; D000293:Adolescent; D000842:Ankle / Q000473:pathology; D018280:Carcinoma, Skin Appendage / Q000473:pathology*; D005260:Female; D006801:Humans; D013544:Sweat Gland Neoplasms / Q000473:pathology*
keywords: adnexa; pediatric; skin; tumor