title: Length-adaptive graph search for automatic segmentation of pathological features in optical coherence tomography images.
abstract: We introduce a metric in graph search and demonstrate its application for segmenting retinal optical coherence tomography (OCT) images of macular pathology. Our proposed “adjusted mean arc length” (AMAL) metric is an adaptation of the lowest mean arc length search technique for automated OCT segmentation. We compare this method to Dijkstra’s shortest path algorithm, which we utilized previously in our popular graph theory and dynamic programming segmentation technique. As an illustrative example, we show that AMAL-based length-adaptive segmentation outperforms the shortest path in delineating the retina/vitreous boundary of patients with full-thickness macular holes when compared with expert manual grading.
authors.affiliation: Duke University, Department of Biomedical Engineering, 101 Science Drive, Campus Box 90281, Durham, North Carolina 27708, United States.
authors.forename: Brenton
authors.initials: B
authors.lastname: Keller
authors.affiliation: Duke University, Department of Biomedical Engineering, 101 Science Drive, Campus Box 90281, Durham, North Carolina 27708, United States.
authors.forename: David
authors.initials: D
authors.lastname: Cunefare
authors.affiliation: Duke University, Department of Ophthalmology, Duke University Medical Center, Durham, North Carolina 27710, United States.
authors.forename: Dilraj S
authors.initials: DS
authors.lastname: Grewal
authors.affiliation: Duke University, Department of Ophthalmology, Duke University Medical Center, Durham, North Carolina 27710, United States.
authors.forename: Tamer H
authors.initials: TH
authors.lastname: Mahmoud
authors.affiliation: Duke University, Department of Biomedical Engineering, 101 Science Drive, Campus Box 90281, Durham, North Carolina 27708, United StatesbDuke University, Department of Ophthalmology, Duke University Medical Center, Durham, North Carolina 27710, United Stat.
authors.forename: Joseph A
authors.initials: JA
authors.lastname: Izatt
authors.affiliation: Duke University, Department of Biomedical Engineering, 101 Science Drive, Campus Box 90281, Durham, North Carolina 27708, United StatesbDuke University, Department of Ophthalmology, Duke University Medical Center, Durham, North Carolina 27710, United Stat.
authors.forename: Sina
authors.initials: S
authors.lastname: Farsiu
mesh_terms: D000465:Algorithms; D006801:Humans; D008268:Macular Degeneration / Q000000981:diagnostic imaging*; D041623:Tomography, Optical Coherence