title: Zika Virus Infects Neural Progenitors in the Adult Mouse Brain and Alters Proliferation.
abstract: Zika virus (ZIKV)-related neuropathology is an important global health concern. Several studies have shown that ZIKV can infect neural stem cells in the developing brain, but infection in the adult brain has not been examined. Two areas in the adult mouse brain contain neural stem cells: the subventricular zone of the anterior forebrain and the subgranular zone of the hippocampus. Here, using 6-week-old mice triply deficient in interferon regulatory factor (IRF) as a model, we show that blood-borne ZIKV administration can lead to pronounced evidence of ZIKV infection in these adult neural stem cells, leading to cell death and reduced proliferation. Our data therefore suggest that adult as well as fetal neural stem cells are vulnerable to ZIKV neuropathology. Thus, although ZIKV is considered a transient infection in adult humans without marked long-term effects, there may in fact be consequences of exposure in the adult brain.
authors.affiliation: Laboratory for Pediatric Brain Diseases, Howard Hughes Medical Institute, The Rockefeller University, New York, NY, USA 10065 and Department of Neurosciences, Rady Children's Institute for Genomic Medicine, University of California, San Diego, La Jolla, CA 92093.
authors.forename: Hongda
authors.initials: H
authors.lastname: Li
authors.affiliation: Laboratory for Pediatric Brain Diseases, Howard Hughes Medical Institute, The Rockefeller University, New York, NY, USA 10065 and Department of Neurosciences, Rady Children's Institute for Genomic Medicine, University of California, San Diego, La Jolla, CA 92093.
authors.forename: Laura
authors.initials: L
authors.lastname: Saucedo-Cuevas
authors.affiliation: Division of Inflammation Biology, La Jolla Institute for Allergy & Immunology, La Jolla, CA, USA 92037.
authors.forename: Jose A
authors.initials: JA
authors.lastname: Regla-Nava
authors.affiliation: Laboratory for Pediatric Brain Diseases, Howard Hughes Medical Institute, The Rockefeller University, New York, NY, USA 10065 and Department of Neurosciences, Rady Children's Institute for Genomic Medicine, University of California, San Diego, La Jolla, CA 92093.
authors.forename: Guoliang
authors.initials: G
authors.lastname: Chai
authors.affiliation: Division of Inflammation Biology, La Jolla Institute for Allergy & Immunology, La Jolla, CA, USA 92037.
authors.forename: Nicholas
authors.initials: N
authors.lastname: Sheets
authors.affiliation: Division of Inflammation Biology, La Jolla Institute for Allergy & Immunology, La Jolla, CA, USA 92037.
authors.forename: William
authors.initials: W
authors.lastname: Tang
authors.affiliation: Del. E. Webb Center for Neuroscience, Aging and Stem Cell Regeneration, Sanford Burnham Prebys Discovery Institute, La Jolla, CA, USA 92037.
authors.forename: Alexey V
authors.initials: AV
authors.lastname: Terskikh
authors.affiliation: Division of Inflammation Biology, La Jolla Institute for Allergy & Immunology, La Jolla, CA, USA 92037.
authors.forename: Sujan
authors.initials: S
authors.lastname: Shresta
authors.affiliation: Laboratory for Pediatric Brain Diseases, Howard Hughes Medical Institute, The Rockefeller University, New York, NY, USA 10065 and Department of Neurosciences, Rady Children's Institute for Genomic Medicine, University of California, San Diego, La Jolla, CA 92093.
authors.forename: Joseph G
authors.initials: JG
authors.lastname: Gleeson
mesh_terms: D000375:Aging / Q000473:pathology*; D000818:Animals; D001921:Brain / Q000473:pathology* / Q000821:virology*; D016923:Cell Death; D049109:Cell Proliferation; D051379:Mice; D058953:Neural Stem Cells / Q000473:pathology* / Q000821:virology*; D000071244:Zika Virus / Q000502:physiology*; D000071243:Zika Virus Infection / Q000473:pathology* / Q000821:virology*
keywords: Zika virus; adult neurogenesis; interferon; neural progenitor cells