title: Progress in systemic therapy of advanced hepatocellular carcinoma.
abstract: Primary liver cancer, mainly consisting of hepatocellular carcinoma (HCC), is one of common malignancies worldwide, and prevalent among the Chinese population. A diagnosis of early stage HCC has proven to be very difficult because of its insidious feature in onset and development. At the time of diagnosis, most HCC cases are locally advanced and/or distant metastatic, which results in difficulty to be treated and poor prognosis. For advanced HCC, systemic therapy is frequently adopted as an important palliative method. In recent years, clinical studies and observations have often reported about systemic anti-cancer therapy of advanced HCC, including molecular target therapy, systemic chemotherapy and immunotherapy. In this article, we review these treatment modalities to provide a reference for clinicians.
authors.affiliation: Xin-Lei Gong, Shu-Kui Qin, Chinese People's Liberation Army Cancer Center, Bayi Hospital, Nanjing 210002, Jiangsu Province, China.
authors.forename: Xin-Lei
authors.initials: XL
authors.lastname: Gong
authors.affiliation: Xin-Lei Gong, Shu-Kui Qin, Chinese People's Liberation Army Cancer Center, Bayi Hospital, Nanjing 210002, Jiangsu Province, China.
authors.forename: Shu-Kui
authors.initials: SK
authors.lastname: Qin
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage; D006528:Carcinoma, Hepatocellular / Q000188:drug therapy*; D003841:Deoxycytidine / Q000008:administration & dosage / Q000031:analogs & derivatives; D005472:Fluorouracil / Q000008:administration & dosage; D006801:Humans; D007167:Immunotherapy; D002955:Leucovorin / Q000008:administration & dosage; D008113:Liver Neoplasms / Q000188:drug therapy*; D020929:Mitogen-Activated Protein Kinase Kinases / Q000037:antagonists & inhibitors; D058990:Molecular Targeted Therapy; D009944:Organoplatinum Compounds / Q000008:administration & dosage; D016212:Transforming Growth Factor beta / Q000037:antagonists & inhibitors
chemical_list: D009944:Organoplatinum Compounds; D016212:Transforming Growth Factor beta; D003841:Deoxycytidine; D020929:Mitogen-Activated Protein Kinase Kinases; D002955:Leucovorin; D005472:Fluorouracil
keywords: Chemotherapy; Hepatocellular carcinoma; Molecular targeted therapy; Progress; Systemic therapy