title: Haptoglobin 2-2 genotype and the risk of coronary artery disease in the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications study (DCCT/EDIC).
abstract: Haptoglobin(Hp) 2-2 genotype has been shown to increase coronary artery disease (CAD) risk in numerous type 2 diabetes studies but in only one type 1 diabetes cohort. We assessed the association of Hp2-2 with incident CAD over 26years of follow-up in 1303 Caucasian participants of the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) study.
  
  
  
  DCCT randomized volunteers with type 1 diabetes to intensive versus conventional therapy within two cohorts: 'primary prevention' with 1-5years diabetes duration and 'secondary intervention' with 1-15years diabetes duration and early retinopathy, with or without albuminuria, but no advanced complications. CAD was defined as myocardial infarction (MI) or death judged to be from CAD, silent MI, angina, coronary revascularization, or congestive heart failure due to CAD.
  
  
  
  In the entire DCCTcohort, Hp2-2 was not significantly associated with incident CAD or MI. However, in pre-specified exploratory subgroup analyses, an increased MI risk was suggested in the secondary cohort for those with Hp2-2.
  
  
  
  The analysis does not statistically confirm an overall association between Hp 2-2 and incident CAD, however, some suggestions of associations were observed in secondary analyses.
authors.affiliation: Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA.
authors.forename: Trevor J
authors.initials: TJ
authors.lastname: Orchard
authors.affiliation: The Biostatistics Center, The George Washington University, Rockville, MD, USA.
authors.forename: Jye-Yu C
authors.initials: JC
authors.lastname: Backlund
authors.affiliation: Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA.
authors.forename: Tina
authors.initials: T
authors.lastname: Costacou
authors.affiliation: The Biostatistics Center, The George Washington University, Rockville, MD, USA.
authors.forename: Patricia
authors.initials: P
authors.lastname: Cleary
authors.affiliation: Medical University of South Carolina, Charleston, SC, USA.
authors.forename: Maria
authors.initials: M
authors.lastname: Lopes-Virella
authors.affiliation: Israel Institute of Technology, Haifa, Israel.
authors.forename: Andrew P
authors.initials: AP
authors.lastname: Levy
authors.affiliation: The Biostatistics Center, The George Washington University, Rockville, MD, USA. Electronic address: jml@bsc.gwu.edu.
authors.forename: John M
authors.initials: JM
authors.lastname: Lachin
mesh_terms: D000328:Adult; D003324:Coronary Artery Disease / Q000235:genetics*; D003924:Diabetes Mellitus, Type 2 / Q000150:complications* / Q000188:drug therapy; D005260:Female; D005838:Genotype; D006242:Haptoglobins / Q000235:genetics*; D006801:Humans; D008297:Male; D012307:Risk Factors; D055815:Young Adult
chemical_list: D006242:Haptoglobins
keywords: Coronary Artery Disease; Diabetes; Epidemiology; Haptoglobin