title: Properties of Cell Sources in Tissue-Engineered Three-dimensional Oral Mucosa Model: A Review.
abstract: Oral mucosa is a mucous membrane lining the oral cavity. Its main function is to protect the deeper structures against the external factors; thermal, chemical, mechanical and biological stimuli. Apart from that, it also plays a significant role during mastication, deglutition and speech. Some oral diseases or injuries to oral mucosa lead to impairment of the oral functions and aesthetics which eventually result in permanent defect of oral mucosa. In order to overcome this defect, different approaches for the development of reconstructed oral mucosa models have been employed including skin/autologous grafts, guided tissue replacement, vestibuloplasty etc. However, the finding of an acceptable source for the transplantations or autologous grafts seems a bit challenging. To overcome this problem, the development of oral mucosa using tissue engineering approach has been widely studied involving various cell lines from different sources. This paper aims to highlight various cell sources used in the development of tissueengineered oral mucosa models based on articles retrieved from PubMed and MEDLINE databases using the search terms "oral mucosa tissue engineering", regardless of time when published.
authors.forename: Nurul Hafizah
authors.initials: NH
authors.lastname: Mohd Nor
authors.affiliation: School of Dental Sciences, Universiti Sains Malaysia, P.O. Box: 16150, Kubang Kerian, Kelantan, Malaysia.
authors.forename: Zurairah
authors.initials: Z
authors.lastname: Berahim
authors.forename: Azlina
authors.initials: A
authors.lastname: Ahmad
authors.forename: Thirumulu Ponnuraj
authors.initials: TP
authors.lastname: Kannan
mesh_terms: D000818:Animals; D006801:Humans; D008954:Models, Biological; D009061:Mouth Mucosa / Q000166:cytology*; D013234:Stem Cells / Q000166:cytology; D023822:Tissue Engineering / Q000379:methods*; D014070:Tooth / Q000166:cytology