title: Undaria pinnatifida and Fucoxanthin Ameliorate Lipogenesis and Markers of Both Inflammation and Cardiovascular Dysfunction in an Animal Model of Diet-Induced Obesity.
abstract: Brown algae and its carotenoids have been shown to have a positive influence on obesity and its comorbidities. This study evaluated the effect of Undaria pinnatifida and fucoxanthin on biochemical, physiological and inflammation markers related to obesity and on the expression of genes engaged on white adipose tissue lipid metabolism in a murine model of diet-induced obesity. The treatments improved energy expenditure, β-oxidation and adipogenesis by upregulating PPARα, PGC1α, PPARγ and UCP-1. Adipogenesis was also confirmed by image analysis of the retroperitoneal adipose tissue, by measuring cell area, perimeter and cellular density. Additionally, the treatments, ameliorated adipose tissue accumulation, insulin resistance, blood pressure, cholesterol and triglycerides concentration in serum, and reduced lipogenesis and inflammation by downregulating acetyl-CoA carboxylase (ACC) gene expression, increasing serum concentration and expression of adiponectin as well as downregulating IL-6 expression. Both fucoxanthin and Undaria pinnatifida may be considered for treating obesity and other diseases related.
authors.affiliation: Departamento de Ingeniería Bioquímica, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Ciudad de México 07738, Mexico. ameyalli.grasa@gmail.com.
authors.forename: Ameyalli
authors.initials: A
authors.lastname: Grasa-López
authors.affiliation: Laboratorio de Biología Molecular, Escuela Superior de Medicina, Instituto Politécnico Nacional, Ciudad de México 11340, Mexico. angel.miliar@yahoo.com.mx.
authors.forename: Ángel
authors.initials: Á
authors.lastname: Miliar-García
authors.affiliation: Departamento de Fisiologia, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Ciudad de México 07738, Mexico. luciaquevedoc@gmail.com.
authors.forename: Lucía
authors.initials: L
authors.lastname: Quevedo-Corona
authors.affiliation: Departamento de Fisiologia, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Ciudad de México 07738, Mexico. npaniag@hotmail.com.
authors.forename: Norma
authors.initials: N
authors.lastname: Paniagua-Castro
authors.affiliation: Departamento de Fisiologia, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Ciudad de México 07738, Mexico. gerescalona@yahoo.com.mx.
authors.forename: Gerardo
authors.initials: G
authors.lastname: Escalona-Cardoso
authors.affiliation: Departamento de Morfología, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Ciudad de México 11340, Mexico. elbareyesm@gmail.com.
authors.forename: Elba
authors.initials: E
authors.lastname: Reyes-Maldonado
authors.affiliation: Departamento de Ingeniería Bioquímica, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Ciudad de México 07738, Mexico. jaramillo_flores@hotmail.com.
authors.forename: María-Eugenia
authors.initials: ME
authors.lastname: Jaramillo-Flores
mesh_terms: D000103:Acetyl-CoA Carboxylase / Q000378:metabolism; D052242:Adiponectin / Q000097:blood / Q000378:metabolism; D052436:Adipose Tissue, White / Q000378:metabolism; D000818:Animals; D015415:Biomarkers / Q000378:metabolism; D059305:Diet, High-Fat / Q000009:adverse effects; D014676:Diet, Vegetarian / Q000379:methods*; D004195:Disease Models, Animal; D006801:Humans; D007249:Inflammation / Q000178:diet therapy; D015850:Interleukin-6 / Q000378:metabolism; D050155:Lipogenesis / Q000187:drug effects*; D008297:Male; D024821:Metabolic Syndrome / Q000178:diet therapy; D009765:Obesity / Q000178:diet therapy* / Q000209:etiology; D047493:PPAR alpha / Q000378:metabolism; D047495:PPAR gamma / Q000378:metabolism; D000071248:Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha / Q000378:metabolism; D000459:Phaeophyceae / Q000737:chemistry*; D051381:Rats; D017208:Rats, Wistar; D000071256:Uncoupling Protein 1 / Q000378:metabolism; D044648:Undaria / Q000737:chemistry*; D024341:Xanthophylls / Q000494:pharmacology* / Q000627:therapeutic use
chemical_list: D052242:Adiponectin; C499920:Adipoq protein, rat; D015415:Biomarkers; D015850:Interleukin-6; D047493:PPAR alpha; D047495:PPAR gamma; C000613696:PPAR gamma, rat; D000071248:Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; C501429:Ppargc1a protein, rat; C000604373:Ucp1 protein, rat; D000071256:Uncoupling Protein 1; D024341:Xanthophylls; C025164:fucoxanthin; D000103:Acetyl-CoA Carboxylase
keywords: Undaria pinnatifida; adipose tissue expansion; energy expenditure; fucoxanthin; gene expression; inflammation; obesity