title: Role of Wnt and Notch signaling in regulating hair cell regeneration in the cochlea.
abstract: Sensory hair cells in the inner ear are responsible for sound recognition. Damage to hair cells in adult mammals causes permanent hearing impairment because these cells cannot regenerate. By contrast, newborn mammals possess limited regenerative capacity because of the active participation of various signaling pathways, including Wnt and Notch signaling. The Wnt and Notch pathways are highly sophisticated and conserved signaling pathways that control multiple cellular events necessary for the formation of sensory hair cells. Both signaling pathways allow resident supporting cells to regenerate hair cells in the neonatal cochlea. In this regard, Wnt and Notch signaling has gained increased research attention in hair cell regeneration. This review presents the current understanding of the Wnt and Notch signaling pathways in the auditory portion of the inner ear and discusses the possibilities of controlling these pathways with the hair cell fate determiner Atoh1 to regulate hair cell regeneration in the mammalian cochlea.
authors.affiliation: Key Laboratory for Developmental Genes and Human Disease, Ministry of Education, Institute of Life Sciences, Southeast University, Nanjing, 210096, China.|Co-Innovation Center of Neuroregeneration, Nantong University, Nantong, 226001, China.
authors.forename: Muhammad
authors.initials: M
authors.lastname: Waqas
authors.affiliation: Key Laboratory for Developmental Genes and Human Disease, Ministry of Education, Institute of Life Sciences, Southeast University, Nanjing, 210096, China.|Co-Innovation Center of Neuroregeneration, Nantong University, Nantong, 226001, China.
authors.forename: Shasha
authors.initials: S
authors.lastname: Zhang
authors.affiliation: Key Laboratory for Developmental Genes and Human Disease, Ministry of Education, Institute of Life Sciences, Southeast University, Nanjing, 210096, China.|Co-Innovation Center of Neuroregeneration, Nantong University, Nantong, 226001, China.
authors.forename: Zuhong
authors.initials: Z
authors.lastname: He
authors.affiliation: Key Laboratory for Developmental Genes and Human Disease, Ministry of Education, Institute of Life Sciences, Southeast University, Nanjing, 210096, China. mingliangtang@seu.edu.cn.|Co-Innovation Center of Neuroregeneration, Nantong University, Nantong, 226001, China. mingliangtang@seu.edu.cn.
authors.forename: Mingliang
authors.initials: M
authors.lastname: Tang
authors.affiliation: Key Laboratory for Developmental Genes and Human Disease, Ministry of Education, Institute of Life Sciences, Southeast University, Nanjing, 210096, China. renjiec@seu.edu.cn.|Co-Innovation Center of Neuroregeneration, Nantong University, Nantong, 226001, China. renjiec@seu.edu.cn.
authors.forename: Renjie
authors.initials: R
authors.lastname: Chai
mesh_terms: D000818:Animals; D002454:Cell Differentiation; D003051:Cochlea / Q000502:physiology*; D006198:Hair Cells, Auditory / Q000502:physiology*; D006801:Humans; D051379:Mice; D051880:Receptors, Notch / Q000502:physiology*; D012038:Regeneration; D060449:Wnt Signaling Pathway
chemical_list: D051880:Receptors, Notch
keywords: Notch; Wnt; cochlea; hair cell; inner ear; regeneration; signaling pathways