title: Preoperative Assessment of Pancreatic Cancer with FDG PET/MR Imaging versus FDG PET/CT Plus Contrast-enhanced Multidetector CT: A Prospective Preliminary Study.
abstract: Purpose To determine the diagnostic performance of fluorine 18 fluorodeoxyglucose (FDG) positron emission tomography (PET)/magnetic resonance (MR) imaging in the preoperative assessment of pancreatic cancer in comparison with that of FDG PET/computed tomography (CT) plus contrast material-enhanced multidetector CT. Materials and Methods This prospective study was approved by the institutional review board; written informed consent was obtained. Thirty-seven patients with 39 pancreatic tumors underwent preoperative FDG PET/MR imaging, PET/CT, and contrast-enhanced multidetector CT. The authors measured maximal and mean standardized uptake values (SUVmaxand SUVmean, respectively) of pancreatic cancer at PET/MR imaging and PET/CT. Two radiologists independently reviewed the two imaging sets (set 1, PET/MR imaging; set 2, PET/CT plus multidetector CT) to determine tumor resectability according to a five-point scale, N stage (N0 or N positive), and M stage (M0 or M1). With use of clinical-surgical-pathologic findings as the standard of reference (n = 20), diagnostic performances of the two imaging sets were compared by using the McNemar test. Results Both SUVmaxand SUVmeanof pancreatic tumors showed strong correlations between PET/MR imaging and PET/CT (r = 0.897 and 0.890, respectively; P < .001). The diagnostic performance of PET/MR imaging was not significantly different from that of PET/CT plus multidetector CT in the assessment of tumor resectability (area under the receiver operating characteristic curve: 0.891 vs 0.776, respectively, for reviewer 1 [P = .109] and 0.859 vs 0.797 for reviewer 2 [P = .561]), N stage (accuracy: 54% [seven of 13 patients] vs 31% [four of 13 patients]; P = .250 for both reviewers), and M stage (accuracy: 94% [16 of 17 patients] vs 88% [15 of 17 patients] for reviewer 1 [P > .999] and 94% [16 of 17 patients] vs 82% [14 of 17 patients] for reviewer 2 [P = .500]). Conclusion FDG PET/MR imaging showed a diagnostic performance similar to that of PET/CT plus contrast-enhanced multidetector CT in the preoperative evaluation of the resectability and staging of pancreatic tumors.©RSNA, 2016 Online supplemental material is available for this article.
authors.affiliation: From the Department of Radiology (I.J., J.M.L., D.H.L.), Institute of Radiation Medicine (J.M.L.), Department of Nuclear Medicine (J.C.P., S.J.L.), Department of Surgery and Cancer Research Institute (J.Y.J., S.W.K.), Division of Gastroenterology, Department of Internal Medicine (J.K.R.), and Department of Pathology (K.B.L.), Seoul National University Hospital, 101 Daehak-ro, Jongno-gu, Seoul 110-744, Korea; and Department of Radiology, Chung-Ang University Hospital, Seoul, Korea (E.S.L.).
authors.forename: Ijin
authors.initials: I
authors.lastname: Joo
authors.affiliation: From the Department of Radiology (I.J., J.M.L., D.H.L.), Institute of Radiation Medicine (J.M.L.), Department of Nuclear Medicine (J.C.P., S.J.L.), Department of Surgery and Cancer Research Institute (J.Y.J., S.W.K.), Division of Gastroenterology, Department of Internal Medicine (J.K.R.), and Department of Pathology (K.B.L.), Seoul National University Hospital, 101 Daehak-ro, Jongno-gu, Seoul 110-744, Korea; and Department of Radiology, Chung-Ang University Hospital, Seoul, Korea (E.S.L.).
authors.forename: Jeong Min
authors.initials: JM
authors.lastname: Lee
authors.affiliation: From the Department of Radiology (I.J., J.M.L., D.H.L.), Institute of Radiation Medicine (J.M.L.), Department of Nuclear Medicine (J.C.P., S.J.L.), Department of Surgery and Cancer Research Institute (J.Y.J., S.W.K.), Division of Gastroenterology, Department of Internal Medicine (J.K.R.), and Department of Pathology (K.B.L.), Seoul National University Hospital, 101 Daehak-ro, Jongno-gu, Seoul 110-744, Korea; and Department of Radiology, Chung-Ang University Hospital, Seoul, Korea (E.S.L.).
authors.forename: Dong Ho
authors.initials: DH
authors.lastname: Lee
authors.affiliation: From the Department of Radiology (I.J., J.M.L., D.H.L.), Institute of Radiation Medicine (J.M.L.), Department of Nuclear Medicine (J.C.P., S.J.L.), Department of Surgery and Cancer Research Institute (J.Y.J., S.W.K.), Division of Gastroenterology, Department of Internal Medicine (J.K.R.), and Department of Pathology (K.B.L.), Seoul National University Hospital, 101 Daehak-ro, Jongno-gu, Seoul 110-744, Korea; and Department of Radiology, Chung-Ang University Hospital, Seoul, Korea (E.S.L.).
authors.forename: Eun Sun
authors.initials: ES
authors.lastname: Lee
authors.affiliation: From the Department of Radiology (I.J., J.M.L., D.H.L.), Institute of Radiation Medicine (J.M.L.), Department of Nuclear Medicine (J.C.P., S.J.L.), Department of Surgery and Cancer Research Institute (J.Y.J., S.W.K.), Division of Gastroenterology, Department of Internal Medicine (J.K.R.), and Department of Pathology (K.B.L.), Seoul National University Hospital, 101 Daehak-ro, Jongno-gu, Seoul 110-744, Korea; and Department of Radiology, Chung-Ang University Hospital, Seoul, Korea (E.S.L.).
authors.forename: Jin Chul
authors.initials: JC
authors.lastname: Paeng
authors.affiliation: From the Department of Radiology (I.J., J.M.L., D.H.L.), Institute of Radiation Medicine (J.M.L.), Department of Nuclear Medicine (J.C.P., S.J.L.), Department of Surgery and Cancer Research Institute (J.Y.J., S.W.K.), Division of Gastroenterology, Department of Internal Medicine (J.K.R.), and Department of Pathology (K.B.L.), Seoul National University Hospital, 101 Daehak-ro, Jongno-gu, Seoul 110-744, Korea; and Department of Radiology, Chung-Ang University Hospital, Seoul, Korea (E.S.L.).
authors.forename: Soo Jin
authors.initials: SJ
authors.lastname: Lee
authors.affiliation: From the Department of Radiology (I.J., J.M.L., D.H.L.), Institute of Radiation Medicine (J.M.L.), Department of Nuclear Medicine (J.C.P., S.J.L.), Department of Surgery and Cancer Research Institute (J.Y.J., S.W.K.), Division of Gastroenterology, Department of Internal Medicine (J.K.R.), and Department of Pathology (K.B.L.), Seoul National University Hospital, 101 Daehak-ro, Jongno-gu, Seoul 110-744, Korea; and Department of Radiology, Chung-Ang University Hospital, Seoul, Korea (E.S.L.).
authors.forename: Jin-Young
authors.initials: JY
authors.lastname: Jang
authors.affiliation: From the Department of Radiology (I.J., J.M.L., D.H.L.), Institute of Radiation Medicine (J.M.L.), Department of Nuclear Medicine (J.C.P., S.J.L.), Department of Surgery and Cancer Research Institute (J.Y.J., S.W.K.), Division of Gastroenterology, Department of Internal Medicine (J.K.R.), and Department of Pathology (K.B.L.), Seoul National University Hospital, 101 Daehak-ro, Jongno-gu, Seoul 110-744, Korea; and Department of Radiology, Chung-Ang University Hospital, Seoul, Korea (E.S.L.).
authors.forename: Sun-Whe
authors.initials: SW
authors.lastname: Kim
authors.affiliation: From the Department of Radiology (I.J., J.M.L., D.H.L.), Institute of Radiation Medicine (J.M.L.), Department of Nuclear Medicine (J.C.P., S.J.L.), Department of Surgery and Cancer Research Institute (J.Y.J., S.W.K.), Division of Gastroenterology, Department of Internal Medicine (J.K.R.), and Department of Pathology (K.B.L.), Seoul National University Hospital, 101 Daehak-ro, Jongno-gu, Seoul 110-744, Korea; and Department of Radiology, Chung-Ang University Hospital, Seoul, Korea (E.S.L.).
authors.forename: Ji Kon
authors.initials: JK
authors.lastname: Ryu
authors.affiliation: From the Department of Radiology (I.J., J.M.L., D.H.L.), Institute of Radiation Medicine (J.M.L.), Department of Nuclear Medicine (J.C.P., S.J.L.), Department of Surgery and Cancer Research Institute (J.Y.J., S.W.K.), Division of Gastroenterology, Department of Internal Medicine (J.K.R.), and Department of Pathology (K.B.L.), Seoul National University Hospital, 101 Daehak-ro, Jongno-gu, Seoul 110-744, Korea; and Department of Radiology, Chung-Ang University Hospital, Seoul, Korea (E.S.L.).
authors.forename: Kyoung-Bun
authors.initials: KB
authors.lastname: Lee
mesh_terms: D003287:Contrast Media; D005260:Female; D019788:Fluorodeoxyglucose F18; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D010190:Pancreatic Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology / Q000601:surgery; D000072078:Positron Emission Tomography Computed Tomography; D057234:Preoperative Period; D011446:Prospective Studies; D019275:Radiopharmaceuticals
chemical_list: D003287:Contrast Media; D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18