title: Role of surgery in the management of anaplastic thyroid carcinoma: Korean nationwide multicenter study of 329 patients with anaplastic thyroid carcinoma, 2000 to 2012.
abstract: The Korean Society of Thyroid Head and Neck Surgery established a nationwide multicenter registry of anaplastic thyroid carcinoma (ATC) and evaluated the prognostic factors and treatment outcomes of ATC.
  
  
  
  The present study enrolled 329 patients who were diagnosed with ATC between January 2000 and December 2012 at 19 medical centers in Korea. Survival outcomes were evaluated according to various clinical factors and treatments.
  
  
  
  Multivariate analysis identified age ≥70 years old, the presence of initial clinical symptoms, distant metastasis, and treatment modality as significant risk factors (p <.05). The patients who underwent curative resection and adjuvant radiotherapy (RT) or concurrent chemoradiotherapy (CRT) showed the best survival on multivariate analysis (p < 0.05).
  
  
  
  Although ATC is a lethal neoplasm, long-term survival may be acquired in cases in which the aggressive management, including curative resection or RT/concurrent CRT, is possible for therapeutic intent. © 2016 Wiley Periodicals, Inc. Head Neck 39: 133-139, 2017.
authors.affiliation: Department of Otorhinolaryngology-Head and Neck Surgery, Korea University College of Medicine, Seoul, Korea.
authors.forename: Seung-Kuk
authors.initials: SK
authors.lastname: Baek
authors.affiliation: Department of Otolaryngology - Head and Neck Surgery, Korea Cancer Center Hospital, Seoul, Korea.
authors.forename: Myung-Chul
authors.initials: MC
authors.lastname: Lee
authors.affiliation: Department of Otorhinolaryngology - Head and Neck Surgery, Seoul National University Hospital, Seoul, Korea.
authors.forename: J Hun
authors.initials: JH
authors.lastname: Hah
authors.affiliation: Department of Otorhinolaryngology - Head and Neck Surgery, Seoul National University Bundang Hospital, Seoul, Korea.
authors.forename: Soon-Hyun
authors.initials: SH
authors.lastname: Ahn
authors.affiliation: Department of Otorhinolaryngology - Head and Neck Surgery, Sungkyunkwan University School of Medicine, Gyeonggi-do, Korea.
authors.forename: Young-Ik
authors.initials: YI
authors.lastname: Son
authors.affiliation: Department of Otorhinolaryngology - Head and Neck Surgery, Hallym University College of Medicine, Gangwon-do, Korea.
authors.forename: Young-Soo
authors.initials: YS
authors.lastname: Rho
authors.affiliation: Department of Otorhinolaryngology - Head and Neck Surgery, Dankook University College of Medicine, Chungnam, Korea.
authors.forename: Phil-Sang
authors.initials: PS
authors.lastname: Chung
authors.affiliation: Department of Otorhinolaryngology - Head and Neck Surgery, Ulsan University College of Medicine, Seoul, Korea.
authors.forename: Yoon-Se
authors.initials: YS
authors.lastname: Lee
authors.affiliation: Department of Otorhinolaryngology-Head and Neck Surgery, Chungnam National University College of Medicine, Daejeon, 305-764, Korea.
authors.forename: Bon Seok
authors.initials: BS
authors.lastname: Koo
authors.affiliation: Department of Otorhinolaryngology-Head and Neck Surgery, Korea University College of Medicine, Seoul, Korea.
authors.forename: Kwang-Yoon
authors.initials: KY
authors.lastname: Jung
authors.affiliation: Department of Otorhinolaryngology - Head and Neck Surgery, Pusan National University School of Medicine and Biomedical Research Institute, Busan, Korea.
authors.forename: Byung-Joo
authors.initials: BJ
authors.lastname: Lee
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D059248:Chemoradiotherapy; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D018714:Radiotherapy, Adjuvant; D056910:Republic of Korea; D012189:Retrospective Studies; D012307:Risk Factors; D015996:Survival Rate; D065646:Thyroid Carcinoma, Anaplastic / Q000401:mortality / Q000473:pathology / Q000628:therapy*; D013964:Thyroid Neoplasms / Q000401:mortality / Q000473:pathology / Q000628:therapy*; D013965:Thyroidectomy; D016896:Treatment Outcome; D055815:Young Adult
keywords: anaplastic thyroid carcinoma; multicenter study; multimodal treatment; prognostic factor; surgery