title: Association between the X-ray repair cross-complementing group 1 Arg194Trp polymorphism and thyroid carcinoma susceptibility: A meta-analysis.
abstract: Previous case-control studies having investigated the relationship between the X-ray repair cross-complementing group 1 (XRCC1) Arg194Trp polymorphism and thyroid cancer (TC) have drawn inconsistent conclusions. The current study aimed to clarify the role of this polymorphism in susceptibility to TC. An up-to-date search of PubMed and Web of Science databases was conducted, including articles published up to August 2015. Crude odds ratios (ORs) with 95%CIs were calculated to establish the association between the XRCC1 Arg194Trp polymorphism and TC risk. Five studies were used, comprising 911 patients and 1476 controls. Our meta-analysis indicated that this polymorphism is associated with TC risk in Caucasians (TrpTrp vs ArgArg: OR = 5.72, 95%CI = 1.39-23.54; ArgTrp vs ArgArg: OR = 1.20, 95%CI = 0.87-1.66; dominant model: OR = 1.31, 95%CI = 0.96-1.79; recessive model: OR = 0.18, 95%CI = 0.04-0.73). This investigation demonstrates that the XRCC1 Arg194Trp polymorphism constitutes a risk factor for TC in Caucasian individuals.
authors.affiliation: Department of Head and Neck Surgery, Zhejiang Provincial Cancer Hospital, Hangzhou, China.
authors.forename: J Z
authors.initials: JZ
authors.lastname: Zhao
authors.affiliation: Department of Head and Neck Surgery, Zhejiang Provincial Cancer Hospital, Hangzhou, China tanxiangrong01@sina.com.
authors.forename: X R
authors.initials: XR
authors.lastname: Tan
authors.affiliation: Department of Head and Neck Surgery, Zhejiang Provincial Cancer Hospital, Hangzhou, China.
authors.forename: M
authors.initials: M
authors.lastname: Zhao
authors.affiliation: Department of Head and Neck Surgery, Zhejiang Provincial Cancer Hospital, Hangzhou, China.
authors.forename: X C
authors.initials: XC
authors.lastname: Mao
authors.affiliation: Department of Head and Neck Surgery, Zhejiang Provincial Cancer Hospital, Hangzhou, China.
authors.forename: L
authors.initials: L
authors.lastname: Jiang
mesh_terms: D004268:DNA-Binding Proteins / Q000235:genetics*; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D016017:Odds Ratio; D011110:Polymorphism, Genetic; D013964:Thyroid Neoplasms / Q000235:genetics*; D000076105:X-ray Repair Cross Complementing Protein 1
chemical_list: D004268:DNA-Binding Proteins; D000076105:X-ray Repair Cross Complementing Protein 1; C000619371:XRCC1 protein, human