title: Mathematical modeling of gonadotropin-releasing hormone signaling.
abstract: Gonadotropin-releasing hormone (GnRH) acts via G-protein coupled receptors on pituitary gonadotropes to control reproduction. These are Gq-coupled receptors that mediate acute effects of GnRH on the exocytotic secretion of luteinizing hormone (LH) and follicle-stimulating hormone (FSH), as well as the chronic regulation of their synthesis. GnRH is secreted in short pulses and GnRH effects on its target cells are dependent upon the dynamics of these pulses. Here we overview GnRH receptors and their signaling network, placing emphasis on pulsatile signaling, and how mechanistic mathematical models and an information theoretic approach have helped further this field.
authors.affiliation: Laboratories for Integrative Neuroscience and Endocrinology, School of Clinical Sciences, University of Bristol, Whitson Street, Bristol, BS1 3NY, UK.
authors.forename: Amitesh
authors.initials: A
authors.lastname: Pratap
authors.affiliation: Laboratories for Integrative Neuroscience and Endocrinology, School of Clinical Sciences, University of Bristol, Whitson Street, Bristol, BS1 3NY, UK.
authors.forename: Kathryn L
authors.initials: KL
authors.lastname: Garner
authors.affiliation: EPSRC Centre for Predictive Modeling in Healthcare, University of Exeter, Exeter, EX4 4QF, UK.
authors.forename: Margaritis
authors.initials: M
authors.lastname: Voliotis
authors.affiliation: Department of Mathematics, College of Engineering, Mathematics and Physical Sciences, University of Exeter, Exeter, EX4 4QF, UK; EPSRC Centre for Predictive Modeling in Healthcare, University of Exeter, Exeter, EX4 4QF, UK.
authors.forename: Krasimira
authors.initials: K
authors.lastname: Tsaneva-Atanasova
authors.affiliation: Laboratories for Integrative Neuroscience and Endocrinology, School of Clinical Sciences, University of Bristol, Whitson Street, Bristol, BS1 3NY, UK. Electronic address: craig.mcardle@bristol.ac.uk.
authors.forename: Craig A
authors.initials: CA
authors.lastname: McArdle
mesh_terms: D000818:Animals; D003198:Computer Simulation; D007987:Gonadotropin-Releasing Hormone / Q000378:metabolism*; D006801:Humans; D007257:Information Theory; D008954:Models, Biological; D015398:Signal Transduction
chemical_list: D007987:Gonadotropin-Releasing Hormone
keywords: ERK; GPCR; GnRH; Mathematical modeling; Mutual information; NFAT