title: Structural elucidation and evaluation of multidrug-resistance modulatory capability of amarissinins A-C, diterpenes derived from Salvia amarissima.
abstract: Three new diterpenes (amarissinins A-C, 1-3) containing several oxygenated functionalities were isolated from the leaves and flowers of Salvia amarissima. The structures of these compounds were established through the analysis of their NMR spectroscopy and mass spectrometry data. The structures of compounds 1 and 2 were confirmed by single crystal X-ray diffraction. Compound 2 was identified as a C-10 epimer of dugesin F (5). The cytotoxic activity of these compounds against five human cancer cell lines was determined. Additionally, the capability to modulate the multidrug resistance (MDR) in the MCF-7 cancer cell line resistant to vinblastine was tested.
authors.affiliation: CONACYT, Proyecto CIIDZA, Instituto Potosino de Investigación Científica y Tecnológica A. C., Camino a la Presa San José 2055, Lomas 4ª Sección, 78216, San Luis Potosí, SLP, Mexico; Departamento de Farmacia, Facultad de Química, Universidad Nacional Autónoma de México, México City 04510, DF, Mexico. Electronic address: francisco.bautista@ipicyt.edu.mx.
authors.forename: Elihú
authors.initials: E
authors.lastname: Bautista
authors.affiliation: Departamento de Farmacia, Facultad de Química, Universidad Nacional Autónoma de México, México City 04510, DF, Mexico.
authors.forename: Mabel
authors.initials: M
authors.lastname: Fragoso-Serrano
authors.affiliation: Instituto de Química, Universidad Nacional Autónoma de México, Circuito Exterior, Ciudad Universitaria, Coyoacán, 04510 Mexico City, Mexico.
authors.forename: Naytzé
authors.initials: N
authors.lastname: Ortiz-Pastrana
authors.affiliation: Instituto de Química, Universidad Nacional Autónoma de México, Circuito Exterior, Ciudad Universitaria, Coyoacán, 04510 Mexico City, Mexico.
authors.forename: Rubén A
authors.initials: RA
authors.lastname: Toscano
authors.affiliation: Instituto de Química, Universidad Nacional Autónoma de México, Circuito Exterior, Ciudad Universitaria, Coyoacán, 04510 Mexico City, Mexico.
authors.forename: Alfredo
authors.initials: A
authors.lastname: Ortega
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000302:isolation & purification; D018360:Crystallography, X-Ray; D045785:Diterpenes, Clerodane / Q000737:chemistry* / Q000302:isolation & purification; D018432:Drug Resistance, Multiple; D004354:Drug Screening Assays, Antitumor; D035264:Flowers / Q000737:chemistry; D006801:Humans; D061986:MCF-7 Cells; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D018515:Plant Leaves / Q000737:chemistry; D027544:Salvia / Q000737:chemistry*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D045785:Diterpenes, Clerodane; C000613507:amarissinin A; C000613506:amarissinin B; C000613508:amarissinin C
keywords: Clerodane diterpenes; Cytotoxic; Lamiaceae; MDR modulation; Salvia amarissima