title: The role of growth factors on hepatic damage in rats with obstructive jaundice.
abstract: In this study, we investigated the affect and the role of growth factors on liver damage. 110 Sprague-Dawley rats were divided into 11 groups: a sham group, a control group, HGF, EGF, IGF, TGF groups of irreversible jaundiced rats and a control group and HGF, EGF, IGF, and TGF groups of reversible jaundiced rats (n = 10). In the irreversible jaundiced groups, the common bile duct was explorated, double ligated, and cut. 150 μg/kg/day HGF, 5 μg/kg/day EGF, 5 μg/kg/day IGF, and 5 μg/kg/day TGF β-1 were injected intraperitoneally after the seventh post-operative day. In the reversible jaundiced group, the common bile duct was ligated and the ligation was resolved on the seventh post-operative day. For 5 days, growth factors were injected at the same dose. Ductal proliferation scores significantly decreased after growth factor administration in the EGF-A and TGF-A groups. Furthermore, ductal proliferation was decreased in the TGF-B group. As a result of this study, HGF was effective in the irreversible jaundiced groups and ineffective in the reversible jaundice groups. EGF was effective in the reversible jaundiced groups and ineffective in the irreversible jaundiced groups. In both the irreversible jaundiced and reversible jaundiced groups, IGF was ineffective, although TGF β-1 was effective. We believe that these results arise from the positive effects of effective doses of growth factor on liver damage.
authors.affiliation: Department of General Surgery, Private Esentepe Hospital, Bursa, Turkey.
authors.forename: Ozgur
authors.identifier: 0000-0002-6080-3206
authors.initials: O
authors.lastname: Turk
authors.affiliation: Department of General Surgery, Eskisehir Osmangazi University Medical Faculty, Eskisehir, Turkey.
authors.forename: Bartu
authors.initials: B
authors.lastname: Badak
authors.affiliation: Department of General Surgery, Eskisehir Osmangazi University Medical Faculty, Eskisehir, Turkey.
authors.forename: Ersin
authors.initials: E
authors.lastname: Ates
authors.affiliation: Department of Pathology, Eskisehir Osmangazi University Medical Faculty, Eskisehir, Turkey.
authors.forename: Emine
authors.initials: E
authors.lastname: Dundar
authors.affiliation: Department of Biochemistry, Eskisehir Osmangazi University Medical Faculty, Eskisehir, Turkey.
authors.forename: Emine
authors.initials: E
authors.lastname: Sutken
keywords: Growth factors; Hepatic injury; Obstructive jaundice