title: Consequences of Obstructive Sleep Apnea: Cardiovascular Risk of Obstructive Sleep Apnea and Whether Continuous Positive Airway Pressure Reduces that Risk.
abstract: Obstructive sleep apnea (OSA) is present in up to 25% of otherwise healthy individuals. OSA is associated with intermittent hypoxia, oxidative stress, sympathetic activation, and an inflammatory response. These perturbations mediate the role of OSA as an independent and modifiable risk factor for cardiovascular disease (CVD). OSA can induce CVD or accelerate the progression of CVD into an end-stage disorder, including heart failure and stroke. Current clinical recommendations are based on existing clinical trial data and the clinical experience of our program; current and future clinical trials will help to optimize management of OSA in the setting of CVD.
authors.affiliation: Internal Medicine-Pulmonary, Allergy, Critical Care, and Sleep Medicine, Wexner Medical Center, The Ohio State University, Suite 200, 473 West 12th Avenue, Columbus, OH 43210-1267, USA.
authors.forename: Rami
authors.initials: R
authors.lastname: Khayat
authors.affiliation: Division of Cardiovascular Medicine (Advanced Heart Failure & Cardiac Transplant), Department of Internal Medicine, Wexner Medical Center, Davis Heart & Lung Research Institute, The Ohio State University, Suite 200, 473 West 12th Avenue, Columbus, OH 43210-1267, USA; Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine (Sleep Medicine), Department of Internal Medicine, Wexner Medical Center, Davis Heart & Lung Research Institute, The Ohio State University, Suite 200, 473 West 12th Avenue, Columbus, OH 43210-1267, USA. Electronic address: adam.pleister@osumc.edu.
authors.forename: Adam
authors.initials: A
authors.lastname: Pleister
mesh_terms: D002318:Cardiovascular Diseases / Q000209:etiology / Q000517:prevention & control*; D045422:Continuous Positive Airway Pressure / Q000379:methods*; D006801:Humans; D020181:Sleep Apnea, Obstructive / Q000150:complications / Q000628:therapy*
keywords: Cardiovascular disease; Coronary artery disease; Heart failure; Intermittent hypoxia; Obstructive sleep apnea; Sleep-disordered breathing; Sympathetic activation; Systemic hypertension