title: The other side of the coin: Leveraging Epstein-Barr virus in research and therapy.
abstract: Epstein-Barr virus is (EBV) a ubiquitous virus prevalent in 90% of the human population. Transmitted through infected saliva, EBV is the causative agent of infectious mononucleosis (IM) and is further implicated in malignancies of lymphoid and epithelial origins. In the past few decades, research efforts primarily focused on dissecting the mechanism of EBV-induced oncogenesis. Here, we present an alternate facet of the oncovirus EBV, on its applications in research and therapy. Finally, discussions on the prospective utilization of EBV in nasopharyngeal carcinoma (NPC) diagnosis and therapy will also be presented.
authors.affiliation: Department of Otolaryngology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore. Electronic address: entyf@nus.edu.sg.
authors.forename: Fenggang
authors.initials: F
authors.lastname: Yu
authors.affiliation: Department of Microbiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
authors.forename: Wei Jian
authors.initials: WJ
authors.lastname: Tan
authors.affiliation: Department of Otolaryngology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
authors.forename: Yanan
authors.initials: Y
authors.lastname: Lu
authors.affiliation: Department of Microbiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
authors.forename: Paul A
authors.initials: PA
authors.lastname: MacAry
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, National University Health System, Singapore.
authors.forename: Kwok Seng
authors.initials: KS
authors.lastname: Loh
mesh_terms: D015316:Genetic Therapy; D005822:Genetic Vectors; D004854:Herpesvirus 4, Human / Q000235:genetics / Q000302:isolation & purification / Q000502:physiology*; D006801:Humans; D007167:Immunotherapy; D008223:Lymphoma / Q000175:diagnosis / Q000628:therapy / Q000821:virology; D009303:Nasopharyngeal Neoplasms / Q000175:diagnosis / Q000628:therapy / Q000821:virology
keywords: Epstein-Barr virus; Lymphoma; Nasopharyngeal carcinoma; Research and therapy