title: An Open-Label Feasibility Trial of Repetitive Transcranial Magnetic Stimulation for Treatment-Resistant Major Depressive Episodes.
abstract: Repetitive transcranial magnetic stimulation (rTMS) has been reported to be a new treatment option for treatment-resistant depression. In Japan, there has been limited research into its feasibility, efficacy, and tolerability. We have launched a trial of rTMS for treating medication-resistant major depressive disorder and bipolar depression. We are investigating low-frequency rTMS to the right dorsolateral prefrontal cortex and traditional high-frequency rTMS to the left dorsolateral prefrontal cortex, in 20 patients. The primary outcome of the study is the treatment completion rate. This study will provide new data on the usefulness of rTMS for treatment-resistant depression in Japan.
authors.affiliation: Department of Neuropsychiatry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Science, Okayama 700-8558, Japan.
authors.forename: Masaki
authors.initials: M
authors.lastname: Fujiwara
authors.forename: Masatoshi
authors.initials: M
authors.lastname: Inagaki
authors.forename: Yuji
authors.initials: Y
authors.lastname: Higuchi
authors.forename: Yosuke
authors.initials: Y
authors.lastname: Uchitomi
authors.forename: Seishi
authors.initials: S
authors.lastname: Terada
authors.forename: Masafumi
authors.initials: M
authors.lastname: Kodama
authors.forename: Yoshiki
authors.initials: Y
authors.lastname: Kishi
authors.forename: Norihito
authors.initials: N
authors.lastname: Yamada
mesh_terms: D000328:Adult; D002985:Clinical Protocols; D003865:Major Depressive Disorder / Q000628:therapy*; D005240:Feasibility Studies; D006801:Humans; D012107:Research Design; D050781:Transcranial Magnetic Stimulation / Q000379:methods*