title: Pancreatic lipase activity in overnight effluent predicts high transport status in peritoneal dialysis patients.
abstract: BACKGROUND
  Long-term peritoneal dialysis (PD) causes peritoneal morphological and functional changes, resulting in high transport status featuring increased peritoneal permeability. High transport status is diagnosed by peritoneal equilibration test (PET), a reliable but time-consuming method. We identifed a reliable biomarker in peritoneal effluent to predict high transport status in PD patients.
  
  
  METHODS
  We collected peritoneal effluent and serum from 33 PD patients and measured common laboratory test parameters. High transport status was determined by PET if the dialysate/plasma ratio of creatinine at 4h dwell (D/P Cr 4h) was ≥0.81.
  
  
  RESULTS
  There were significant correlations between D/P Cr 4h and some laboratory parameters in overnight effluent (pancreatic lipase activity, r=0.65, p<0.001; β2-microglobulin concentration, r=0.59, p<0.001; IL-6 concentration, r=0.53, p<0.001; and CA125 concentration, r=0.29, p=0.027). In a multivariate logistic regression analysis, the pancreatic lipase activity in overnight effluent was identified as an independent predictor of high transport status even after adjusting for age, PD duration, and glomerular filtration rate [OR=1.43 (95% CI: 1.11-1.83), p=0.005].
  
  
  CONCLUSIONS
  The pancreatic lipase activity in overnight effluent is an independent predictor of high transport status in PD patients.
authors.affiliation: Department of Clinical Laboratory Medicine, Juntendo University Graduate School of Medicine, Hongo 2-1-1, Bunkyo-ku, Tokyo 113-8421, Japan. Electronic address: midei@juntendo.ac.jp.
authors.forename: Mayumi
authors.initials: M
authors.lastname: Idei
authors.affiliation: Department of Clinical Laboratory Medicine, Juntendo University Graduate School of Medicine, Hongo 2-1-1, Bunkyo-ku, Tokyo 113-8421, Japan.
authors.forename: Yoko
authors.initials: Y
authors.lastname: Tabe
authors.affiliation: Division of Nephrology, Department of Internal Medicine, Juntendo University Faculty of Medicine, Hongo 2-1-1, Bunkyo-ku, Tokyo 113-8421, Japan.
authors.forename: Chieko
authors.initials: C
authors.lastname: Hamada
authors.affiliation: Department of Clinical Laboratory Medicine, Juntendo University Graduate School of Medicine, Hongo 2-1-1, Bunkyo-ku, Tokyo 113-8421, Japan.
authors.forename: Kazunori
authors.initials: K
authors.lastname: Miyake
authors.affiliation: Department of Clinical Laboratory, Juntendo University Hospital, Hongo 3-1-1, Bunkyo-ku, Tokyo 113-8421, Japan.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Takemura
authors.affiliation: Division of Nephrology, Department of Internal Medicine, Juntendo University Faculty of Medicine, Hongo 2-1-1, Bunkyo-ku, Tokyo 113-8421, Japan.
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Io
authors.affiliation: Department of Clinical Laboratory, Juntendo University Hospital, Hongo 3-1-1, Bunkyo-ku, Tokyo 113-8421, Japan.
authors.forename: Mitsuru
authors.initials: M
authors.lastname: Wakita
authors.affiliation: Department of Clinical Laboratory, Juntendo University Hospital, Hongo 3-1-1, Bunkyo-ku, Tokyo 113-8421, Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Horii
authors.affiliation: Division of Nephrology, Department of Internal Medicine, Juntendo University Faculty of Medicine, Hongo 2-1-1, Bunkyo-ku, Tokyo 113-8421, Japan.
authors.forename: Yasuhiko
authors.initials: Y
authors.lastname: Tomino
authors.affiliation: Department of Clinical Laboratory, Juntendo University Hospital, Hongo 3-1-1, Bunkyo-ku, Tokyo 113-8421, Japan.
authors.forename: Akimichi
authors.initials: A
authors.lastname: Ohsaka
authors.affiliation: Department of Clinical Laboratory Medicine, Juntendo University Graduate School of Medicine, Hongo 2-1-1, Bunkyo-ku, Tokyo 113-8421, Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Miida
mesh_terms: D015415:Biomarkers / Q000097:blood; D018394:CA-125 Antigen / Q000097:blood; D004789:Enzyme Activation; D005260:Female; D006801:Humans; D015850:Interleukin-6 / Q000097:blood; D008049:Lipase / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D010179:Pancreas / Q000201:enzymology*; D010530:Peritoneal Dialysis / Q000009:adverse effects; D010539:Permeability
chemical_list: D015415:Biomarkers; D018394:CA-125 Antigen; D015850:Interleukin-6; D008049:Lipase
keywords: Effluent biomarker; End-stage renal disease; Peritoneal damage; Peritoneal equilibration test; Peritoneal permeability