title: [The impact of HLA haplotype and alleles mismatches of donor-recipient pairs on outcome of haploidentical hematopoietic stem cell transplantation with a third part cord blood unit].
abstract: OBJECTIVE
  To analyze allele mismatches of HLA- A, - B, - C, - DRB1, - DQB1 and haplotype mismatch of donor- recipient pairs on the outcome of haploidentical transplantation combined with a third part cord blood unit.
  
  
  METHODS
  230 pairs of donor-recipient were performed HLA-A, B, C, DRB1, DQB1 typing using SBT and SSOP methods from January 2012 to December 2014.
  
  
  RESULTS
  Pairs were divided into HLA- 5/10、6/10、7/10 and ≥8/10 groups according to HLA- A, B, C and DRB1 highresolution typing and matched degrees, the 3-year probability of overall survival (OS) for each group were 48.7%, 59.3%, 71.1%, 38.3% (P=0.068) respectively. HLA-6/10 matched group associated with significant favorable effect on OS compared with HLA- 5/10 matched one (P=0.041).When the HLA class I antigen matched on the recipient and donor, improved OS and event free survival (EFS) in HLA- 6/10 matched group than in HLA-5/10 matched one (P=0.017,P=0.088), especially in single HLA-A loci allele matched one (P=0.013,P=0.013), were observed. As to the third part cord blood unit, sharing the same haplotype with the recipient-donor pairs produced better platelet recovery than the misfit one (95.3%vs 86.2%,P= 0.007), similar result was found in terms of neutrophil recovery (98.8%vs 96.1% ,P=0.022).
  
  
  CONCLUSIONS
  HLA locus mismatch and haplotype mismatch of the donor and recipient should be useful for selection of the most optimum donor. Co- infused of an unrelated cord blood unit sharing the same haplotype with the recipient-donor pairs could improve hematopoietic recovery.
authors.affiliation: The First Affiliated Hospital of Soochow University, Jiangsu Institute of Hematology, Suzhou 215006, China.
authors.forename: W J
authors.initials: WJ
authors.lastname: Zhu
authors.forename: J
authors.initials: J
authors.lastname: He
authors.forename: X J
authors.initials: XJ
authors.lastname: Bao
authors.forename: X N
authors.initials: XN
authors.lastname: Yuan
authors.forename: Y
authors.initials: Y
authors.lastname: Li
authors.forename: S L
authors.initials: SL
authors.lastname: Xue
authors.forename: Z J
authors.initials: ZJ
authors.lastname: Pan
authors.forename: J
authors.initials: J
authors.lastname: Chen
authors.forename: D P
authors.initials: DP
authors.lastname: Wu
mesh_terms: D000483:Alleles; D005312:Fetal Blood / Q000637:transplantation*; D006239:Haplotypes; D018380:Hematopoietic Stem Cell Transplantation; D015395:Histocompatibility Antigens Class I / Q000235:genetics*; D006650:Histocompatibility Testing; D006801:Humans; D014019:Tissue Donors; D066027:Transplant Recipients
chemical_list: D015395:Histocompatibility Antigens Class I