title: A change of colloid from hydroxyethyl starch to gelatin does not reduce rate of renal failure or mortality in surgical critical care patients: Results of a retrospective cohort study.
abstract: Hydroxyethyl starch (HES) may compromise renal function in critically ill patients. As an alternative, gelatin (GEL) was suggested. This study investigated whether GEL (4%) may have advantages over HES (6%, 130/0.4) with respect to acute renal failure (ARF), length of intensive care unit /hospital stay, and 30-day mortality and evaluated dose-dependent effects.
  
  
  
  We performed a retrospective cohort analysis of 1522 surgical intensive care patients in a single university hospital where HES was changed to GEL in June 2006. The year before, 515 patients received HES; the year after, 540 patients received GEL. Within both years, 497 patients received crystalloids (CRY) only. Fluid therapy was performed upon clinical judgment and did not follow a study protocol.
  
  
  
  There was no difference in ARF between HES and GEL (P=.292), but ARF was more frequent in both colloid cohorts compared with CRY (HES/GEL vs CRY, P<.05). Mortality and maximum daily dose of both HES (r=0.93) and GEL (r=0.93) were significantly correlated, but mortality and total amount of CRY or total fluid intake were not significantly correlated. Cumulative amounts of fluids given were significantly higher in both colloid groups compared with CRY only, and GEL was given in higher doses than HES. In both colloid cohorts, the need for renal replacement therapy and 30-day mortality were significantly higher, and intensive care unit and hospital stay was longer, compared with CRY.
  
  
  
  A change of colloid from HES to GEL did not reduce the rate of ARF or mortality in surgical critical care patients. Both colloids appear to have dose-dependent effects on renal function.
authors.affiliation: Department of Anesthesiology, Intensive Care and Pain Therapy, Saarland University Medical Center, D-66421, Homburg, Saar, Germany. Electronic address: frederic.albrecht@uks.eu.
authors.forename: Frederic W
authors.initials: FW
authors.lastname: Albrecht
authors.affiliation: Department of Intensive Care Medicine, Inselspital/Universitätsspital Bern, Bern, Switzerland. Electronic address: michael.glas@insel.ch.
authors.forename: Michael
authors.initials: M
authors.lastname: Glas
authors.affiliation: Department of Anesthesiology and Critical Care Medicine, Leopoldina Hospital, D-97422, Schweinfurt, Germany. Electronic address: hrensing@leopoldina.de.
authors.forename: Hauke
authors.initials: H
authors.lastname: Rensing
authors.affiliation: Department of Anaesthesiology, Düsseldorf University Hospital, D-40225, Düsseldorf, Germany. Electronic address: kindgen-milles@med.uni-duesseldorf.de.
authors.forename: Detlef
authors.initials: D
authors.lastname: Kindgen-Milles
authors.affiliation: Department of Anesthesiology, Intensive Care and Pain Therapy, Saarland University Medical Center, D-66421, Homburg, Saar, Germany. Electronic address: thomas.volk@uks.eu.
authors.forename: Thomas
authors.initials: T
authors.lastname: Volk
authors.affiliation: Department of Anaesthesiology, Düsseldorf University Hospital, D-40225, Düsseldorf, Germany. Electronic address: alexander.mathes@med.uni-duesseldorf.de.
authors.forename: Alexander M
authors.initials: AM
authors.lastname: Mathes
mesh_terms: D058186:Acute Kidney Injury / Q000453:epidemiology* / Q000628:therapy; D000368:Aged; D016022:Case-Control Studies; D003102:Colloids / Q000627:therapeutic use; D003422:Critical Care; D016638:Critical Illness / Q000628:therapy*; D000077324:Crystalloid Solutions; D005260:Female; D005440:Fluid Therapy / Q000379:methods*; D005780:Gelatin / Q000627:therapeutic use*; D017052:Hospital Mortality; D006801:Humans; D006895:Hydroxyethyl Starch Derivatives / Q000627:therapeutic use*; D007362:Intensive Care Units; D007552:Isotonic Solutions / Q000627:therapeutic use; D007902:Length of Stay; D008297:Male; D008875:Middle Aged; D017582:Renal Replacement Therapy / Q000706:statistics & numerical data; D012189:Retrospective Studies
chemical_list: D003102:Colloids; D000077324:Crystalloid Solutions; D006895:Hydroxyethyl Starch Derivatives; D007552:Isotonic Solutions; D005780:Gelatin
keywords: Colloids; Crystalloids; Gelatin; Hydroxyethyl starch; Kidney injury; Mortality