title: Effects on cardiovascular risk factors of weight losses limited to 5-10.
abstract: Little is known about the cardiovascular effects of modest weight loss. To determine whether weight losses limited to 5-10 % are sufficient to produce cardiovascular health benefits, data from 401 overweight and obese adults who enrolled in a behavioral weight loss program from 2003 to 2011 were analyzed. Primary outcomes were changes in fasting glucose, triglycerides, and cholesterol. Patients who lost 5-10 % showed significant reductions in triglycerides, total cholesterol, and low-density lipoprotein (LDL) cholesterol. Patients who lost >10 % experienced significantly greater improvements in triglycerides, total cholesterol, and LDL cholesterol than patients losing less. For higher-risk patients, those who lost 5-10 % significantly reduced fasting glucose, triglycerides, and total cholesterol; those who lost >10 % improved on all risk factors (except HDL cholesterol) and to a significantly greater degree than those losing less. Five to 10 % weight losses produced improvements in cardiovascular risk factors, but greater weight losses were associated with even greater improvement.
authors.affiliation: Weight Management Center, Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, SC, USA.
authors.forename: Joshua D
authors.initials: JD
authors.lastname: Brown
authors.affiliation: Now with the Institute of Health Research and Policy and University of Illinois Cancer Center, University of Illinois at Chicago, 1747 W Roosevelt Rd., Chicago, IL, 60608, USA. jbuscemi@uic.edu.
authors.forename: Joanna
authors.initials: J
authors.lastname: Buscemi
authors.affiliation: Now with Department of Mental Health and Behavioral Sciences, James A. Haley VA, Tampa, FL, USA.
authors.forename: Vanessa
authors.initials: V
authors.lastname: Milsom
authors.affiliation: Weight Management Center, Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, SC, USA.
authors.forename: Robert
authors.initials: R
authors.lastname: Malcolm
authors.affiliation: Weight Management Center, Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, SC, USA.
authors.forename: Patrick M
authors.initials: PM
authors.lastname: O'Neil
mesh_terms: D000328:Adult; D001786:Blood Glucose / Q000032:analysis; D002318:Cardiovascular Diseases / Q000150:complications*; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000150:complications / Q000178:diet therapy*; D050177:Overweight / Q000150:complications; D012189:Retrospective Studies; D012307:Risk Factors; D014280:Triglycerides / Q000097:blood; D015431:Weight Loss / Q000502:physiology*; D061217:Weight Reduction Programs / Q000379:methods*
chemical_list: D001786:Blood Glucose; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D014280:Triglycerides; D002784:Cholesterol
keywords: Cardiovascular disease; Obesity; Risk factors; Weight loss