title: Evaluation of Tpeak-Tend interval and Tpeak-end/QT ratio in patients with Sarcoidosis.
abstract: rdiogram (ECG), can be used as a marker of transmural dispersion of repolarization. Also, Tp-e/QT and Tp-e/QTc ratios are used as an index of arrhythmogenesis. Prolonged Tp-e interval and Tp-e/QT ratio was found associated with sudden cardiac death in different clinical conditions. Novel ventricular repolarization parameters, Tp-e interval, Tp-e/QT and Tp-e/QTc ratios have not been evaluated in patients with sarcoidosis without cardiac symptoms previously.Therefore, we investigated Tp-e interval in patients with pulmonary sarcoidosis.
  
  
  METHODS
  Sixty-one consecutive patients diagnosed with biopsy-proven pulmonary sarcoidosis were retrospectively reviewed. The 12-lead ECG examinations were performed at speed of 25 mm/s while the patients were in supine position.  QT dispersion, Tp-e intervals and Tp-e/QT ratio were measured.
  
  
  RESULTS
  Comparison of ECG parameters between two groups showed a significantly higher average heart rate (p< 0.05) in the patients with sarcoidosis than controls. QT dispersion was higher in patients group. Tp-e interval was significantly prolonged in the study group compared to the control group (92±21 ms and 85±14 ms, respectively; p< 0.05). Tp-e/QT and Tp-e/QTc ratios were significantly higher in patients with sarcoidosis compared to control subjects (all p values < 0.05).
  
  
  CONCLUSIONS
  The novel repolarization parameters Tp-e interval, Tp-e/QT and Tp-e/QTc ratios are increased in patients with sarcoidosis without any cardiac symptoms. These parameters might be used as a marker for predicting the ventricular arrhythmias and sudden cardiac death in patients with sarcoidosis.
authors.affiliation: . fdemircisular@ymail.com.
authors.forename: Fatma
authors.initials: F
authors.lastname: Ucsular
authors.forename: Gülistan
authors.initials: G
authors.lastname: Karadeniz
authors.forename: Cem
authors.initials: C
authors.lastname: Karadeniz
authors.forename: Enver
authors.initials: E
authors.lastname: Yalnız
authors.forename: Melike
authors.initials: M
authors.lastname: Demir
mesh_terms: D000200:Action Potentials; D000328:Adult; D001145:Arrhythmias, Cardiac / Q000175:diagnosis* / Q000209:etiology / Q000401:mortality / Q000503:physiopathology; D016757:Death, Sudden, Cardiac / Q000209:etiology; D004562:Electrocardiography; D005260:Female; D006329:Heart Conduction System / Q000503:physiopathology*; D006352:Heart Ventricles / Q000503:physiopathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D056888:Patient Positioning / Q000379:methods; D011237:Predictive Value of Tests; D011379:Prognosis; D012189:Retrospective Studies; D012307:Risk Factors; D017565:Sarcoidosis, Pulmonary / Q000150:complications* / Q000175:diagnosis / Q000401:mortality; D016683:Supine Position; D013997:Time Factors
keywords: Electrocardiogram, sarcoidosis, Tpeak-Tend interval, Tp-e/QT ration