title: Changes in Right Ventricular Dysfunction After Balloon Pulmonary Angioplasty in Patients With Chronic Thromboembolic Pulmonary Hypertension.
abstract: The aim was to investigate the effect of balloon pulmonary angioplasty (BPA) on right ventricular (RV) function in chronic thromboembolic pulmonary hypertension. Twenty-six patients with chronic thromboembolic pulmonary hypertension were enrolled and were divided into 2 groups, group H with high (>30 mm Hg) mean pulmonary arterial pressure and group L with low (25 to 30 mm Hg) mean pulmonary arterial pressure. RV function was assessed using 2-dimensional speckle-tracking echocardiography as well as 3-dimensional echocardiography, and RV dyssynchrony was assessed by the RV strain curves. Exercise capacity was evaluated by the 6-minute walk distance. RV dilatation was significantly reduced after BPA. In group H, RV ejection fraction, RV free wall longitudinal strain and RV dyssynchrony were all impaired before BPA and were ameliorated after BPA. In group L, RV ejection fraction as well as RV dyssynchrony were impaired without the reduction of RV free wall longitudinal strain and were improved after BPA, indicating that RV dysfunction may be attributable to the RV dyssynchrony in group L. Furthermore, RV dyssynchrony at baseline was the only parameter that was correlated with improvement in the 6-minute walk distance after BPA. RV dyssynchrony may affect RV function and could be the useful parameter for clinical outcome after BPA.
authors.affiliation: Department of Cardiology, Center for Clinical Research, School of Medicine, Keio University, Tokyo, Japan.
authors.forename: Toshimitsu
authors.initials: T
authors.lastname: Tsugu
authors.affiliation: Department of Cardiology, Center for Clinical Research, School of Medicine, Keio University, Tokyo, Japan; Department of Laboratory Medicine, Center for Clinical Research, School of Medicine, Keio University, Tokyo, Japan. Electronic address: muratam@keio.jp.
authors.forename: Mitsushige
authors.initials: M
authors.lastname: Murata
authors.affiliation: Department of Cardiology, Center for Clinical Research, School of Medicine, Keio University, Tokyo, Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Kawakami
authors.affiliation: Department of Cardiology, Center for Clinical Research, School of Medicine, Keio University, Tokyo, Japan.
authors.forename: Yugo
authors.initials: Y
authors.lastname: Minakata
authors.affiliation: Department of Cardiology, Center for Clinical Research, School of Medicine, Keio University, Tokyo, Japan.
authors.forename: Hideaki
authors.initials: H
authors.lastname: Kanazawa
authors.affiliation: Department of Cardiology, Center for Clinical Research, School of Medicine, Keio University, Tokyo, Japan.
authors.forename: Masaharu
authors.initials: M
authors.lastname: Kataoka
authors.affiliation: Department of Cardiology, Center for Clinical Research, School of Medicine, Keio University, Tokyo, Japan.
authors.forename: Jin
authors.initials: J
authors.lastname: Endoh
authors.affiliation: Department of Cardiology, Center for Clinical Research, School of Medicine, Keio University, Tokyo, Japan.
authors.forename: Hikaru
authors.initials: H
authors.lastname: Tsuruta
authors.affiliation: Department of Cardiology, Center for Clinical Research, School of Medicine, Keio University, Tokyo, Japan.
authors.forename: Yuji
authors.initials: Y
authors.lastname: Itabashi
authors.affiliation: Department of Cardiology, Center for Clinical Research, School of Medicine, Keio University, Tokyo, Japan.
authors.forename: Yuichiro
authors.initials: Y
authors.lastname: Maekawa
authors.affiliation: Department of Preventive Medicine and Public Health, Center for Clinical Research, School of Medicine, Keio University, Tokyo, Japan.
authors.forename: Takayuki
authors.initials: T
authors.lastname: Abe
authors.affiliation: Department of Cardiology, Center for Clinical Research, School of Medicine, Keio University, Tokyo, Japan.
authors.forename: Keiichi
authors.initials: K
authors.lastname: Fukuda
mesh_terms: D000368:Aged; D000800:Angioplasty, Balloon; D002908:Chronic Disease; D004452:Echocardiography; D019560:Echocardiography, Three-Dimensional; D017079:Exercise Tolerance; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006976:Hypertension, Pulmonary / Q000000981:diagnostic imaging / Q000209:etiology / Q000503:physiopathology / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D011651:Pulmonary Artery / Q000601:surgery*; D011655:Pulmonary Embolism / Q000150:complications / Q000601:surgery*; D013318:Stroke Volume; D016896:Treatment Outcome; D018497:Ventricular Dysfunction, Right / Q000000981:diagnostic imaging / Q000209:etiology / Q000503:physiopathology / Q000601:surgery*; D020257:Ventricular Remodeling; D000070857:Walk Test