title: Chitosan-functionalised poly(2-hydroxyethyl methacrylate) core-shell microgels as drug delivery carriers: salicylic acid loading and release.
abstract: This work presents the evaluation of chitosan-functionalised poly(2-hydroxyethyl methacrylate) (CS/PHEMA) core-shell microgels as drug delivery carriers. CS/PHEMA microgels were prepared by emulsifier-free emulsion polymerisation with N,N '-methylenebisacrylamide (MBA) as a crosslinker. The study on drug loading, using salicylic acid (SA) as a model drug, was performed. The results showed that the encapsulation efficiency (EE) increased as drug-to-microgel ratio was increased. Higher EE can be achieved with the increase in degree of crosslinking, by increasing the amount of MBA from 0.01 g to 0.03 g. In addition, the highest EE (61.1%) was observed at pH 3. The highest release of SA (60%) was noticed at pH 2.4, while the lowest one (49.4%) was obtained at pH 7.4. Moreover, the highest release of SA was enhanced by the presence of 0.2 M NaCl. The pH- and ionic-sensitivity of CS/PHEMA could be useful as a sustained release delivery device, especially for oral delivery.
authors.affiliation: a Department of Chemistry, Faculty of Science , Mahidol University , Bangkok , Thailand.|b Center of Excellent for Innovation in Chemistry (PERCH-CIC) , Bangkok , Thailand.
authors.forename: Natshisa
authors.initials: N
authors.lastname: Mahattanadul
authors.affiliation: a Department of Chemistry, Faculty of Science , Mahidol University , Bangkok , Thailand.|b Center of Excellent for Innovation in Chemistry (PERCH-CIC) , Bangkok , Thailand.
authors.forename: Panya
authors.initials: P
authors.lastname: Sunintaboon
authors.affiliation: a Department of Chemistry, Faculty of Science , Mahidol University , Bangkok , Thailand.
authors.forename: Piyawan
authors.initials: P
authors.lastname: Sirithip
authors.affiliation: a Department of Chemistry, Faculty of Science , Mahidol University , Bangkok , Thailand.|b Center of Excellent for Innovation in Chemistry (PERCH-CIC) , Bangkok , Thailand.
authors.forename: Patoomratana
authors.initials: P
authors.lastname: Tuchinda
mesh_terms: D048271:Chitosan / Q000737:chemistry*; D004337:Drug Carriers / Q000737:chemistry / Q000493:pharmacokinetics; D005782:Gels; D011109:Polymethacrylic Acids / Q000737:chemistry*; D020156:Salicylic Acid / Q000737:chemistry / Q000493:pharmacokinetics
chemical_list: D004337:Drug Carriers; D005782:Gels; D011109:Polymethacrylic Acids; D048271:Chitosan; D020156:Salicylic Acid
keywords: Chitosan; core-shell; drug delivery; microgel; poly(2-hydroxyethyl methacrylate); salicylic acid