title: Indeterminate cell histiocytosis successfully treated with phototherapy.
abstract: First described in 1985, intermediate cell histiocytosis is a rare disorder of the cutaneous dendritic cell group with a varied clinical presentation and evolution. The pathologic substrate is constituted by the proliferation of indeterminate cells (ICs) that are immunophenotypically characterized by the positivity of CD1a, CD68, and faint/focal S100, plus the negativity for CD207 (langerin). The authors present the case of a healthy elderly woman who presented generalized dome-shaped reddish cutaneous nodules over her trunk, neck, face, and extremities over a period of 18 months. A laboratory and imaging work-up ruled out internal involvement. The skin biopsy was consistent with IC histiocytosis. The patient was treated with narrowband ultraviolet B phototherapy, which resulted in an excellent short-term outcome.
authors.affiliation: Department of Pathology - Faculty of Medicine - University of São Paulo, São Paulo/SP - Brazil .
authors.forename: Maria Claudia Nogueira
authors.initials: MC
authors.lastname: Zerbini
authors.affiliation: Department of Pathology - Faculty of Medicine - University of São Paulo, São Paulo/SP - Brazil .
authors.forename: Mirian Nacagami
authors.initials: MN
authors.lastname: Sotto
authors.affiliation: Internal Medicine Division - Hospital Universitário - University of São Paulo, São Paulo/SP - Brazil .
authors.forename: Fernando Peixoto Ferraz
authors.initials: FP
authors.lastname: de Campos
authors.affiliation: Hematologic Oncology Department - Instituto do Câncer de São Paulo, São Paulo/SP - Brazil .
authors.forename: Andre Neder Ramires
authors.initials: AN
authors.lastname: Abdo
authors.affiliation: Hematologic Oncology Department - Instituto do Câncer de São Paulo, São Paulo/SP - Brazil.; Department of Hematology - Faculty of Medicine - University of São Paulo, São Paulo/SP - Brazil.
authors.forename: Juliana
authors.initials: J
authors.lastname: Pereira
authors.affiliation: Dermatology Department - Faculty of Medicine - Hospital das Clínicas - University of São Paulo, São Paulo/SP - Brazil .
authors.forename: José Antônio
authors.initials: JA
authors.lastname: Sanches
authors.affiliation: Dermatology Department - Faculty of Medicine - Hospital das Clínicas - University of São Paulo, São Paulo/SP - Brazil .
authors.forename: Jade Cury
authors.initials: JC
authors.lastname: Martins
keywords: Histiocytosis; Phototherapy; Skin Diseases