title: Rheumatologic Manifestations of Hematologic Neoplasms.
abstract: BACKGROUND
  The rheumatologic manifestations of hematologic neoplasms are a collection of diverse syndromes. This review aims to describe the most common syndromes in the context of potential mechanisms of pathogenesis.
  
  
  METHODS
  We undertook a structured search of the available peer-reviewed literature describing paraneoplastic phenomena associated with hematologic neoplasms and the most current literature on the biology of inflammation and neoplasm.
  
  
  RESULTS
  This review describes the common rheumatologic manifestations and discusses their possible underlying pathogenesis.
  
  
  CONCLUSIONS
  This review describes common clinical features of paraneoplastic phenomena prevalent in hematologic malignancies that may help differentiate them from primary rheumatologic disease and discusses the most current understanding of underlying pathogenesis with a specific focus on the biology of inflammation in neoplastic transformation.
authors.affiliation: Section of Hematology, Department of Internal Medicine, Yale University, 333 Cedar Street, PO Box 208028, New Haven, CT 06520-8028,. United States.
authors.forename: A
authors.initials: A
authors.lastname: Wang
authors.forename: C M
authors.initials: CM
authors.lastname: Brunet
authors.forename: A M
authors.initials: AM
authors.lastname: Zeidan
mesh_terms: D019337:Hematologic Neoplasms / Q000150:complications*; D006801:Humans; D010257:Paraneoplastic Syndromes / Q000209:etiology* / Q000473:pathology*; D012216:Rheumatic Diseases / Q000209:etiology* / Q000473:pathology*
keywords: Antibody-mediated; disorder; inflammation; neoplasm; paraneoplastic; prototypic