title: Increased task demand during spatial memory testing recruits the anterior cingulate cortex.
abstract: We examined whether increasing retrieval difficulty in a spatial memory task would promote the recruitment of the anterior cingulate cortex (ACC) similar to what is typically observed during remote memory retrieval. Rats were trained on the hidden platform version of the Morris Water Task and tested three or 30 d later. Retrieval difficulty was manipulated by removing several prominent extra-pool cues from the testing room. Immediate early gene expression (c-Fos) in the ACC was greater following the cue removal and comparable to remote memory retrieval (30-d retention interval) levels, supporting the view of increased ACC contribution during high cognitive-demand memory processes.
authors.affiliation: Department of Psychology, Trent University, Peterborough, Ontario K9J 7B8, Canada.
authors.forename: Joshua K
authors.initials: JK
authors.lastname: Carr
authors.affiliation: Department of Psychology, Trent University, Peterborough, Ontario K9J 7B8, Canada.
authors.forename: Neil M
authors.initials: NM
authors.lastname: Fournier
authors.affiliation: Department of Psychology, Trent University, Peterborough, Ontario K9J 7B8, Canada hugolehmann@trentu.ca.
authors.forename: Hugo
authors.initials: H
authors.lastname: Lehmann
mesh_terms: D000818:Animals; D003463:Cues; D006179:Gyrus Cinguli / Q000502:physiology*; D008297:Male; D018782:Maze Learning; D057567:Memory, Long-Term; D011939:Mental Recall / Q000502:physiology*; D017207:Rats, Sprague-Dawley; D065852:Spatial Memory / Q000502:physiology*