title: p53, a potential predictor of Helicobacter pylori infection-associated gastric carcinogenesis?
abstract: Helicobacter pylori (H. pylori) is an ancient and persistent inhabitant of the human stomach that is closely linked to the development of gastric cancer (GC). . Emerging evidence suggests that H. pylori strain interactions with gastric epithelial cells subvert the best- characterized p53 tumour suppressor pathway. A high prevalence of p53 mutations is related to H. pylori infection. H. pylori also accelerates p53 protein degradation by disturbing the MDM2-P53 feedback loop. Additionally, H. pylori triggers the alteration of other p53 isoforms. Dysregulation of p53 by H. pylori infection contributes to gastric carcinogenesis by mediating cell proliferation and apoptosis. This review focuses on the regulation of p53 in H. pylori infection-associated GC.
authors.affiliation: Department of Gastroenterology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China.
authors.forename: Nianshuang
authors.initials: N
authors.lastname: Li
authors.affiliation: Department of Gastroenterology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China.
authors.forename: Chuan
authors.initials: C
authors.lastname: Xie
authors.affiliation: Department of Gastroenterology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China.
authors.forename: Nong-Hua
authors.initials: NH
authors.lastname: Lu
mesh_terms: D063646:Carcinogenesis / Q000378:metabolism / Q000473:pathology*; D016481:Helicobacter Infections / Q000150:complications* / Q000821:virology; D016480:Helicobacter pylori / Q000472:pathogenicity*; D006801:Humans; D013274:Stomach Neoplasms / Q000175:diagnosis* / Q000209:etiology / Q000378:metabolism; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism*
chemical_list: C495901:TP53 protein, human; D016159:Tumor Suppressor Protein p53
keywords: Helicobacter pylori; p53; tumourigenesis