title: 3D printing of PLGA scaffolds for tissue engineering.
abstract: We proposed a novel method of generation of bioresorbable polymeric scaffolds with specified architectonics for tissue engineering using extrusion three-dimensional (3D) printing with solutions of polylactoglycolide in tetraglycol with their subsequent solidifying in aqueous medium. On the basis of 3D computer models, we obtained the matrix structures with interconnected system of pores ranging in size from 0.5 to 500 µm. The results of in vitro studies using cultures of line NIH 3Т3 mouse fibroblasts, floating islet cultures of newborn rabbit pancreas, and mesenchymal stem cells of human adipose tissue demonstrated the absence of cytotoxicity and good adhesive properties of scaffolds in regard to the cell cultures chosen. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 105A: 104-109, 2017.
authors.affiliation: Insitute of Photonic Technologies, Federal Reseach Center "Chrystallography and Photonics", Moscow, Russia.
authors.forename: Anton V
authors.initials: AV
authors.lastname: Mironov
authors.affiliation: Academician V.I. Shumakov Federal Research Center of Transplantology and Artificial Organs, Ministry of Health of the Russian Federation, Moscow, Russia.
authors.forename: Aleksey M
authors.initials: AM
authors.lastname: Grigoryev
authors.affiliation: Insitute of Photonic Technologies, Federal Reseach Center "Chrystallography and Photonics", Moscow, Russia.
authors.forename: Larisa I
authors.initials: LI
authors.lastname: Krotova
authors.affiliation: Academician V.I. Shumakov Federal Research Center of Transplantology and Artificial Organs, Ministry of Health of the Russian Federation, Moscow, Russia.
authors.forename: Nikolaj N
authors.initials: NN
authors.lastname: Skaletsky
authors.affiliation: Insitute of Photonic Technologies, Federal Reseach Center "Chrystallography and Photonics", Moscow, Russia.
authors.forename: Vladimir K
authors.initials: VK
authors.lastname: Popov
authors.affiliation: Academician V.I. Shumakov Federal Research Center of Transplantology and Artificial Organs, Ministry of Health of the Russian Federation, Moscow, Russia.
authors.forename: Viktor I
authors.initials: VI
authors.lastname: Sevastianov
mesh_terms: D000818:Animals; D005347:Fibroblasts / Q000166:cytology / Q000378:metabolism*; D007515:Islets of Langerhans / Q000166:cytology / Q000378:metabolism*; D019344:Lactic Acid / Q000737:chemistry*; D008422:Materials Testing; D051379:Mice; D041681:NIH 3T3 Cells; D011100:Polyglycolic Acid / Q000737:chemistry*; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D066330:Printing, Three-Dimensional; D011817:Rabbits; D054457:Tissue Scaffolds / Q000737:chemistry*
chemical_list: D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D019344:Lactic Acid
keywords: 3D printing; bioresorbable polymeric scaffolds; polylactic-co-glycolic acids; tissue engineering