title: Analysis of pregnancy outcome and decline of anti-Müllerian hormone after laparoscopic cystectomy for ovarian endometriomas.
abstract: OBJECTIVE
  Excision of ovarian endometrioma (OE) may induce the reduction of ovarian reserve. We evaluated pregnancy outcomes after laparoscopic cystectomy (LC), and the pre- and postoperative levels of anti-Müllerian hormone (AMH) to consider the ovarian reserve.
  
  
  METHODS
  We enrolled 40 women with OE and 16 women with benign ovarian tumors who hoped to have a child and who underwent LC. To evaluate the ovarian reserve of 40 patients (OE group, n = 24; non-OE group, n = 16), we measured serum AMH levels before and after the surgery.
  
  
  RESULTS
  In the 40 women who underwent LC for OE, the cumulative pregnancy rate was 50%. Prior to the cystectomy, serum AMH levels in the OE group, especially in patients over the age of 35, were significantly lower than those in the non-OE group. Rate of decline in serum AMH in the OE group was significant compared with that in the non-OE group 6 months after surgery. In patients over the age of 35 in the OE group, AMH levels 1 year after surgery decreased noticeably.
  
  
  CONCLUSIONS
  LC for OE could be a preferred surgical approach, but effective therapeutic strategies will have to be developed to prevent damage to the ovarian reserve, especially for older patients.
authors.affiliation: Department of Obstetrics and Gynecology, Tottori University Faculty of Medicine, Yonago, Japan. tani4327@med.tottori-u.ac.jp.
authors.forename: Fuminori
authors.initials: F
authors.lastname: Taniguchi
authors.affiliation: Department of Obstetrics and Gynecology, Tottori University Faculty of Medicine, Yonago, Japan.
authors.forename: Yasuko
authors.initials: Y
authors.lastname: Sakamoto
authors.affiliation: Department of Obstetrics and Gynecology, Tottori University Faculty of Medicine, Yonago, Japan.
authors.forename: Yuko
authors.initials: Y
authors.lastname: Yabuta
authors.affiliation: Department of Obstetrics and Gynecology, Tottori University Faculty of Medicine, Yonago, Japan.
authors.forename: Yukihiro
authors.initials: Y
authors.lastname: Azuma
authors.affiliation: Department of Obstetrics and Gynecology, Tottori University Faculty of Medicine, Yonago, Japan.
authors.forename: Eriko
authors.initials: E
authors.lastname: Hirakawa
authors.affiliation: Department of Obstetrics and Gynecology, Tottori University Faculty of Medicine, Yonago, Japan.
authors.forename: Kei
authors.initials: K
authors.lastname: Nagira
authors.affiliation: Department of Obstetrics and Gynecology, Tottori University Faculty of Medicine, Yonago, Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Uegaki
authors.affiliation: Department of Obstetrics and Gynecology, Tottori University Faculty of Medicine, Yonago, Japan.
authors.forename: Imari
authors.initials: I
authors.lastname: Deura
authors.affiliation: Department of Nursing, The University of Shimane, Izumo, Japan.
authors.forename: Koukichi
authors.initials: K
authors.lastname: Hata
authors.affiliation: Department of Obstetrics and Gynecology, Tottori University Faculty of Medicine, Yonago, Japan.
authors.forename: Tasuku
authors.initials: T
authors.lastname: Harada
mesh_terms: D000328:Adult; D054304:Anti-Mullerian Hormone / Q000097:blood*; D004715:Endometriosis / Q000097:blood / Q000601:surgery*; D005260:Female; D006801:Humans; D010535:Laparoscopy / Q000009:adverse effects*; D010048:Ovarian Cysts / Q000601:surgery*; D065851:Ovarian Reserve; D010053:Ovary / Q000378:metabolism* / Q000601:surgery; D011247:Pregnancy; D011256:Pregnancy Outcome; D018873:Pregnancy Rate; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D054304:Anti-Mullerian Hormone
keywords: AMH; cystectomy; ovarian endometrioma