title: Penicillium keratitis in a HIV-infected patient.
abstract: A 36-year-old HIV-positive man presented with symptoms of redness, blurred vision and foreign body sensation in his right eye for 3 months. The slit lamp examination revealed deep stromal infiltration with a feathery margin in an otherwise minimal anterior chamber reaction. A corneal scraping was negative. Confocal microscopy demonstrated an abnormal large hyper-reflective oval shape in the corneal stroma. Corneal infiltration did not show improvement after topical, intrastromal and intracameral antifungal treatment. Therapeutic penetrating keratoplasty was performed to eradicate the infection. Corneal button culture and histopathological results confirmed the diagnosis of Penicillium marneffei keratitis. No recurrent infection occurred after corneal transplantation. This appears to be the first report of P. marneffei keratitis in an HIV-infected patient. Although it is an uncommon condition, it should be one of the differential diagnoses in an HIV-infected patient presenting with keratitis.
authors.affiliation: Faculty of Medicine, Department of Ophthalmology, Srinagarind Hospital, Khon Kaen University, Moung, Thailand.
authors.forename: Orapin
authors.initials: O
authors.lastname: Anutarapongpan
authors.affiliation: Department of Ophthalmology, Khon Kaen University, Khon Kaen, Thailand.
authors.forename: Onsiri
authors.initials: O
authors.lastname: Thanathanee
authors.affiliation: Department of Ophthalmology, Khon Kaen University, Khon Kaen, Thailand.
authors.forename: Olan
authors.initials: O
authors.lastname: Suwan-Apichon
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000000981:diagnostic imaging* / Q000188:drug therapy; D000328:Adult; D000935:Antifungal Agents / Q000008:administration & dosage; D003937:Diagnosis, Differential; D004359:Drug Therapy, Combination; D015821:Eye Infections, Fungal / Q000000981:diagnostic imaging* / Q000188:drug therapy; D006801:Humans; D007634:Keratitis / Q000000981:diagnostic imaging* / Q000188:drug therapy; D008297:Male; D018613:Microscopy, Confocal; D010407:Penicillium
chemical_list: D000935:Antifungal Agents