title: Azobenzene photocontrol of peptides and proteins.
abstract: The last few years have witnessed significant advances in the use of light as a stimulus to control biomolecular interactions. Great efforts have been devoted to the development of genetically encoded optobiological and small photochromic switches. Newly discovered small molecules now allow researchers to build molecular systems that are sensitive to a wider range of wavelengths of light than ever before with improved switching fidelities and increased lifetimes of the photoactivated states. Because these molecules are relatively small and adopt predictable conformations they are well suited as tools to interrogate cellular function in a spatially and temporally contolled fashion and for applications in photopharmacology.
authors.affiliation: School of Chemistry & Cardiff Catalysis Institute, Cardiff University, Park Place, Cardiff, CF10 3AT, UK. allemannrk@cardiff.ac.uk.
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Mart
authors.affiliation: School of Chemistry & Cardiff Catalysis Institute, Cardiff University, Park Place, Cardiff, CF10 3AT, UK. allemannrk@cardiff.ac.uk.
authors.forename: Rudolf K
authors.initials: RK
authors.lastname: Allemann
mesh_terms: D001391:Azo Compounds / Q000737:chemistry*; D006367:HeLa Cells; D006801:Humans; D008027:Light; D010446:Peptide Fragments / Q000737:chemistry* / Q000528:radiation effects; D011487:Protein Conformation / Q000528:radiation effects*; D014168:Transferrin / Q000737:chemistry* / Q000528:radiation effects
chemical_list: D001391:Azo Compounds; D010446:Peptide Fragments; D014168:Transferrin; C009850:azobenzene