title: Current Perspectives on Gastric Cancer.
abstract: Gastric cancer (GC) is third leading cause of cancer-related death. Only 28.3% of new GC cases survive more than 5 years. Although incidence has declined in the United States, an increase is estimated for 2016. Risk factors include sex (risk is higher in men), Helicobacter pylori infection, heredity, and lifestyle. GC is usually diagnosed between the ages of 60-80 years. Prognosis of GC is largely dependent on the tumor stage at diagnosis and classification as intestinal or diffuse type; diffuse-type GC has worse prognosis. Chemoprevention has been shown to decrease risk, but is currently not used clinically.
authors.affiliation: Division of Gastroenterology, Department of Medicine, University of Puerto Rico School of Medicine, San Juan, PR 00935, USA.
authors.forename: Juan M
authors.initials: JM
authors.lastname: Marqués-Lespier
authors.affiliation: University of Puerto Rico Comprehensive Cancer Center, San Juan, PR 00935, USA.
authors.forename: María
authors.initials: M
authors.lastname: González-Pons
authors.affiliation: Departments of Medicine, Surgery, and Biochemistry, University of Puerto Rico, Medical Sciences Campus, San Juan, PR 00935, USA. Electronic address: marcia.cruz1@upr.edu.
authors.forename: Marcia
authors.initials: M
authors.lastname: Cruz-Correa
mesh_terms: D000230:Adenocarcinoma / Q000175:diagnosis / Q000453:epidemiology* / Q000473:pathology / Q000628:therapy; D000428:Alcohol Drinking; D000911:Antibodies, Monoclonal; D061067:Antibodies, Monoclonal, Humanized; D000970:Antineoplastic Agents; D004032:Diet; D020031:Epstein-Barr Virus Infections / Q000453:epidemiology*; D005743:Gastrectomy; D005757:Gastritis, Atrophic / Q000453:epidemiology*; D020022:Genetic Predisposition to Disease; D016481:Helicobacter Infections / Q000453:epidemiology*; D016480:Helicobacter pylori; D006801:Humans; D008679:Metaplasia; D009765:Obesity / Q000453:epidemiology*; D016273:Occupational Exposure / Q000706:statistics & numerical data*; D012307:Risk Factors; D017678:Sex Distribution; D012907:Smoking / Q000453:epidemiology*; D013274:Stomach Neoplasms / Q000175:diagnosis / Q000453:epidemiology* / Q000473:pathology / Q000628:therapy; D000068878:Trastuzumab; D000096662:Ramucirumab
chemical_list: D000911:Antibodies, Monoclonal; D061067:Antibodies, Monoclonal, Humanized; D000970:Antineoplastic Agents; D000068878:Trastuzumab; D000096662:Ramucirumab
keywords: Atrophic gastritis; Dysplasia; Gastric cancer; Helicobacter pylori; Intestinal metaplasia