title: Chemokines accentuating protumoral activities in oral cancer microenvironment possess an imperious stratagem for therapeutic resolutions.
abstract: Chemokines, the chemotactic cytokines have established their role in tumorigenesis and tumor progression. Studies, which explored their role in oral cancer for protumoral activity, point towards targeting chemokines for oral squamous cell carcinoma therapy. The need of the hour is to emphasize/divulge in the activities of chemokine ligands and their receptors in the tumor microenvironment for augmentation of such stratagems. This progressing sentience of chemokines and their receptors has inspired this review which is an endeavour to comprehend their role as an aid in accentuating hallmarks of cancer and targeted therapy.
authors.affiliation: Department of Oral Pathology and Microbiology, Institute of Dental Sciences, Siksha 'O' Anusandhan University, Bhubaneswar 751030, India. Electronic address: dr.swagatika@gmail.com.
authors.forename: Swagatika
authors.initials: S
authors.lastname: Panda
authors.affiliation: Department of Oral and Maxillofacial Surgery, Institute of Dental Sciences, Siksha 'O' Anusandhan University, Bhubaneswar 751030, India. Electronic address: subrat.padhiary@gmail.com.
authors.forename: Subrat Kumar
authors.initials: SK
authors.lastname: Padhiary
authors.affiliation: Department of Oral Pathology and Microbiology, Institute of Dental Sciences, Siksha 'O' Anusandhan University, Bhubaneswar 751030, India. Electronic address: drroutray.samapika@gmail.com.
authors.forename: Samapika
authors.initials: S
authors.lastname: Routray
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000276:immunology / Q000473:pathology* / Q000628:therapy*; D018925:Chemokines / Q000502:physiology*; D006801:Humans; D009062:Mouth Neoplasms / Q000276:immunology / Q000473:pathology* / Q000628:therapy*; D019707:Receptors, Chemokine; D059016:Tumor Microenvironment
chemical_list: D018925:Chemokines; D019707:Receptors, Chemokine
keywords: Chemokines; OSCC; Therapeutic target; Tumor microenvironment