title: Human pancreatic cancer progression: an anarchy among CCN-siblings.
abstract: Decades of basic and translational studies have identified the mechanisms by which pancreatic cancer cells use molecular pathways to hijack the normal homeostasis of the pancreas, promoting pancreatic cancer initiation, progression, and metastasis, as well as drug resistance. These molecular pathways were explored to develop targeted therapies to prevent or cure this fatal disease. Regrettably, the studies found that majority of the molecular events that dictate carcinogenic growth in the pancreas are non-actionable (potential non-responder groups of targeted therapy). In this review we discuss exciting discoveries on CCN-siblings that reveal how CCN-family members contribute to the different aspects of the development of pancreatic cancer with special emphasis on therapy.
authors.affiliation: Cancer Research Unit, VA Medical Center, Kansas City, 4801 Linwood Blvd, Kansas City, MO, 64128, USA. sbanerjee2@kumc.edu.|Department of Oncology, University of Kansas Medical Center, Kansas City, Kansas, USA. sbanerjee2@kumc.edu.|Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, Kansas, USA. sbanerjee2@kumc.edu.|Department of Anatomy and Cell Biology, University of Kansas Medical Center, Kansas City, Kansas, USA. sbanerjee2@kumc.edu.
authors.forename: Sushanta K
authors.initials: SK
authors.lastname: Banerjee
authors.affiliation: Cancer Research Unit, VA Medical Center, Kansas City, 4801 Linwood Blvd, Kansas City, MO, 64128, USA.|Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, Kansas, USA.
authors.forename: Gargi
authors.initials: G
authors.lastname: Maity
authors.affiliation: Cancer Research Unit, VA Medical Center, Kansas City, 4801 Linwood Blvd, Kansas City, MO, 64128, USA.|Department of Oncology, University of Kansas Medical Center, Kansas City, Kansas, USA.
authors.forename: Inamul
authors.initials: I
authors.lastname: Haque
authors.affiliation: Cancer Research Unit, VA Medical Center, Kansas City, 4801 Linwood Blvd, Kansas City, MO, 64128, USA.|Department of Oncology, University of Kansas Medical Center, Kansas City, Kansas, USA.
authors.forename: Arnab
authors.initials: A
authors.lastname: Ghosh
authors.affiliation: Cancer Research Unit, VA Medical Center, Kansas City, 4801 Linwood Blvd, Kansas City, MO, 64128, USA.|Department of Anatomy and Cell Biology, University of Kansas Medical Center, Kansas City, Kansas, USA.
authors.forename: Sandipto
authors.initials: S
authors.lastname: Sarkar
authors.affiliation: Cancer Research Unit, VA Medical Center, Kansas City, 4801 Linwood Blvd, Kansas City, MO, 64128, USA.|Department of Oncology, University of Kansas Medical Center, Kansas City, Kansas, USA.
authors.forename: Vijayalaxmi
authors.initials: V
authors.lastname: Gupta
authors.affiliation: University of Missouri Kansas City and Saint Luke's Hospital, Kansas City, MO, USA.
authors.forename: Donald R
authors.initials: DR
authors.lastname: Campbell
authors.affiliation: Translational Genomic Research Institute (TGen), Phoenix, AZ, USA.
authors.forename: Daniel
authors.initials: D
authors.lastname: Von Hoff
authors.affiliation: Cancer Research Unit, VA Medical Center, Kansas City, 4801 Linwood Blvd, Kansas City, MO, 64128, USA. sbanerjee@kumc.edu.|Department of Oncology, University of Kansas Medical Center, Kansas City, Kansas, USA. sbanerjee@kumc.edu.
authors.forename: Snigdha
authors.initials: S
authors.lastname: Banerjee
keywords: CCN1; CCN2; CCN3; CCN4; CCN5; Genetically engineered mice model; Pancreatic cancer; Patient derived xenograft