title: Choroidal neovascularisation on optical coherence tomography angiography in punctate inner choroidopathy and multifocal choroiditis.
abstract: OBJECTIVE
  To describe the findings seen on optical coherence tomography angiography (OCTA) in patients with punctate inner choroidopathy (PIC) and multifocal choroiditis and panuveitis (MCP) complicated by choroidal neovascular membranes.
  
  
  METHODS
  This was an Institutional Review Board-approved prospective, descriptive case series. 12 patients with PIC and MCP complicated by choroidal neovascularisation (CNV) were included. Each patient underwent slit-lamp examination by a uveitis specialist followed by conventional spectral domain OCT imaging of the macula. OCTA images of the macula were then obtained.
  
  
  RESULTS
  12 patients were enrolled in the study, out of which 9 patients were followed longitudinally. CNV was identified in 11 of the 12 patients. In all patients where fluorescein angiography (FA) was inconclusive for presence of CNV, OCTA identified CNV. Various lesions on OCT suggestive of activity correlated with changes in the vascular structure of OCTA to confirm suspicion of clinical activity.
  
  
  CONCLUSIONS
  In patients with PIC and MCP complicated by CNV, OCTA successfully identified underlying CNV. Given the difficulty of differentiating inflammatory lesions from early CNV on OCT and FA, OCTA may provide a valuable method of monitoring patients with posterior uveitis highly correlated with development of CNV.
authors.affiliation: Retinal Consultants of Arizona, , Phoenix, AZ, USA.
authors.forename: Ashleigh L
authors.initials: AL
authors.lastname: Levison
authors.affiliation: Cole Eye Institute, Cleveland Clinic Foundation, Cleveland, Ohio, USA.
authors.forename: Kimberly M
authors.initials: KM
authors.lastname: Baynes
authors.affiliation: Cole Eye Institute, Cleveland Clinic Foundation, Cleveland, Ohio, USA.
authors.forename: Careen Y
authors.initials: CY
authors.lastname: Lowder
authors.affiliation: Cole Eye Institute, Cleveland Clinic Foundation, Cleveland, Ohio, USA.
authors.forename: Peter K
authors.initials: PK
authors.lastname: Kaiser
authors.affiliation: Cole Eye Institute, Cleveland Clinic Foundation, Cleveland, Ohio, USA.
authors.forename: Sunil K
authors.initials: SK
authors.lastname: Srivastava
mesh_terms: D000328:Adult; D020533:Angiogenesis Inhibitors / Q000627:therapeutic use; D000068258:Bevacizumab / Q000627:therapeutic use; D020256:Choroidal Neovascularization / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000473:pathology*; D002833:Choroiditis / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000473:pathology*; D005260:Female; D005451:Fluorescein Angiography; D006801:Humans; D008297:Male; D008875:Middle Aged; D000080364:Multifocal Choroiditis; D015864:Panuveitis / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000473:pathology*; D011446:Prospective Studies; D012189:Retrospective Studies; D013256:Steroids / Q000627:therapeutic use; D041623:Tomography, Optical Coherence / Q000379:methods*; D014792:Visual Acuity; D055815:Young Adult
chemical_list: D020533:Angiogenesis Inhibitors; D013256:Steroids; D000068258:Bevacizumab
keywords: Inflammation; Neovascularisation; Retina