title: Primary angiomatoid fibrous histiocytoma of the lung with mediastinal lymph node metastasis.
abstract: Angiomatoid fibrous histiocytoma (AFH), a rare soft tissue tumor of borderline malignancy, typically occurs in the subcutis of the accessible soft tissues, most often in children and young adults. Lymph node and/or distant metastasis is seen in less than 2% of patients with AFH. Exceptionally rare examples of AFH have been reported in visceral locations, including the lung. We report a genetically confirmed primary pulmonary AFH in a 70-year-old woman with mediastinal lymph node metastasis, representing to the best of our knowledge the first report of metastases from a visceral AFH.
authors.affiliation: Department of Respiratory and Critical Care Medicine, Singapore General Hospital, Outram Road, Singapore 169608.
authors.forename: Chee Kiang
authors.initials: CK
authors.lastname: Tay
authors.affiliation: Department of Respiratory and Critical Care Medicine, Singapore General Hospital, Outram Road, Singapore 169608.
authors.forename: Mariko Siyue
authors.initials: MS
authors.lastname: Koh
authors.affiliation: Department of Pathology, Singapore General Hospital/Duke-NUS Graduate Medical School, Outram Road, Singapore 169608.
authors.forename: Angela
authors.initials: A
authors.lastname: Takano
authors.affiliation: Department of Laboratory Medicine and Pathology, Division of Anatomic Pathology, Mayo Clinic, Rochester, MN 55905, USA.
authors.forename: Marie Christine
authors.initials: MC
authors.lastname: Aubry
authors.affiliation: Division of Laboratory Genetics, Mayo Clinic, Rochester, MN 55905, USA.
authors.forename: William R
authors.initials: WR
authors.lastname: Sukov
authors.affiliation: Department of Laboratory Medicine and Pathology, Division of Anatomic Pathology, Mayo Clinic, Rochester, MN 55905, USA. Electronic address: folpe.andrew@mayo.edu.
authors.forename: Andrew L
authors.initials: AL
authors.lastname: Folpe
mesh_terms: D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis / Q000235:genetics; D001706:Biopsy; D002148:Calmodulin-Binding Proteins / Q000235:genetics; D005260:Female; D015321:Gene Rearrangement; D051677:Histiocytoma, Malignant Fibrous / Q000737:chemistry / Q000235:genetics / Q000556:secondary*; D006801:Humans; D007150:Immunohistochemistry; D017404:In Situ Hybridization, Fluorescence; D008175:Lung Neoplasms / Q000737:chemistry / Q000235:genetics / Q000473:pathology*; D008198:Lymph Nodes / Q000737:chemistry / Q000473:pathology*; D008207:Lymphatic Metastasis; D008482:Mediastinum; D034802:RNA-Binding Protein EWS; D016601:RNA-Binding Proteins / Q000235:genetics; D014057:Tomography, X-Ray Computed
chemical_list: D014408:Biomarkers, Tumor; D002148:Calmodulin-Binding Proteins; C500986:EWSR1 protein, human; D034802:RNA-Binding Protein EWS; D016601:RNA-Binding Proteins
keywords: Angiomatoid fibrous histiocytoma; EWSR1; Fluorescence in situ hybridization; Pulmonary neoplasms; Soft tissue neoplasms