title: VIGABATRIN TOXICITY IN INFANCY IS ASSOCIATED WITH RETINAL DEFECT IN ADOLESCENCE: A Prospective Observational Study.
abstract: OBJECTIVE
  The purpose was to determine whether vigabatrin (VGB) (Sabril)-attributed retinal toxicity defined by electroretinogram in early childhood is associated with visual system defect in adolescents after discontinuation of VGB.
  
  
  METHODS
  This prospective cross-sectional study included 24 children previously treated with VGB and monitored in early childhood by electroretinogram for VGB-attributed retinal defects. Ten had been diagnosed with VGB-attributed retinal defect (Group I) and 14 had no VGB-attributed retinal defect (Group II). Outcome measures were extent of monocular visual fields using Goldmann kinetic perimetry and RNFL thickness at the optic nerve head, using optical coherence tomography.
  
  
  RESULTS
  Of those able to complete testing (6 eyes Group I and 16 eyes Group II), Goldmann results revealed results of visual field loss in Group I and not in Group II. The optical coherence tomography results demonstrated attenuation of the RNFL in all 6 eyes of Group I participants and in only 1 eye of 10 Group II participants. Optical coherence tomography data were nonoverlapping between Group 1 and Group II eyes.
  
  
  CONCLUSIONS
  The VGB-attributed retinal toxicity identified by means of electroretinogram in infancy was associated with visual field loss and RNFL attenuation of the retinal nerve when tested in adolescence.
authors.affiliation: *Department of Ophthalmology and Vision Science, The Hospital for Sick Children, Toronto, Ontario, Canada; and †University of Toronto, Toronto, Ontario, Canada.
authors.forename: Tom
authors.initials: T
authors.lastname: Wright
authors.forename: Ananthavalli
authors.initials: A
authors.lastname: Kumarappah
authors.forename: Aphrodite
authors.initials: A
authors.lastname: Stavropoulos
authors.forename: Arun
authors.initials: A
authors.lastname: Reginald
authors.forename: J Raymond
authors.initials: JR
authors.lastname: Buncic
authors.forename: Carol A
authors.initials: CA
authors.lastname: Westall
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000927:Anticonvulsants / Q000009:adverse effects*; D002648:Child; D003430:Cross-Sectional Studies; D004596:Electroretinography; D005260:Female; D006801:Humans; D008297:Male; D009898:Optic Disk / Q000473:pathology; D011446:Prospective Studies; D012160:Retina / Q000187:drug effects*; D012164:Retinal Diseases / Q000139:chemically induced* / Q000473:pathology / Q000503:physiopathology; D020888:Vigabatrin / Q000009:adverse effects*; D014794:Visual Fields / Q000502:physiology; D055815:Young Adult
chemical_list: D000927:Anticonvulsants; D020888:Vigabatrin