title: A review of immunogenicity and tolerability of live attenuated Hepatitis A vaccine in children.
abstract: Changing epidemiology of Hepatitis A virus (HAV) has led to an increased susceptibility of adolescents and adults to the infection. Vaccination can remarkably reduce the incidence and associated morbidity of HAV infection. This review is focused on the safety and efficacy of H2 strain derived live attenuated Hepatitis A vaccine. We found the vaccine to be highly immunogenic with minimal or negligible safety issues. Moreover, a single dose of live attenuated vaccine persists a long term immune response and can be a preferred option for developing countries. In 2014, Indian Academy of Paediatrics (IAP) also updated their recommendations for H2 vaccine as a single dose as against the previous 2 dose schedule. A focused approach to include the vaccine in national immunization program should be explored.
authors.affiliation: a Medical Affairs Department , Wockhardt Ltd , Bandra (East), Mumbai , India.
authors.forename: Sameer
authors.initials: S
authors.lastname: Rao
authors.affiliation: b Institute of Viral Diseases, Zhejiang Academy of Medical Sciences , Hangzhou , China.
authors.forename: J S
authors.initials: JS
authors.lastname: Mao
authors.affiliation: a Medical Affairs Department , Wockhardt Ltd , Bandra (East), Mumbai , India.
authors.forename: Salman
authors.initials: S
authors.lastname: Motlekar
authors.affiliation: b Institute of Viral Diseases, Zhejiang Academy of Medical Sciences , Hangzhou , China.
authors.forename: Zhuang
authors.initials: Z
authors.lastname: Fangcheng
authors.affiliation: a Medical Affairs Department , Wockhardt Ltd , Bandra (East), Mumbai , India.
authors.forename: Ganesh
authors.initials: G
authors.lastname: Kadhe
mesh_terms: D002648:Child; D002675:Child, Preschool; D006506:Hepatitis A / Q000517:prevention & control*; D022362:Hepatitis A Vaccines / Q000009:adverse effects* / Q000276:immunology*; D006801:Humans; D007194:India; D014613:Vaccines, Attenuated / Q000009:adverse effects / Q000276:immunology
chemical_list: D022362:Hepatitis A Vaccines; D014613:Vaccines, Attenuated
keywords: Hepatitis A; immunogenicity; live attenuated vaccine; safety; seroconversion