title: Dibutyryl-cAMP affecting fat deposition of finishing pigs by decreasing the inflammatory system related to insulin sensitive or lipolysis.
abstract: BACKGROUND
  The mechanism of db-cAMP regulating fat deposition and improving lean percentage is unclear and needs to be further studied.
  
  
  METHODS
  Eighteen 100-day-old Duroc × Landrance × Large White barrows (49.75 ± 0.75 kg) were used for experiment 1, and 15 eighteen 135-day-old barrows (78.34 ± 1.22 kg) were used for experiment 2 to investigate the effects of dietary dibutyryl-cAMP (db-cAMP) on fat deposition in finishing pigs. Pigs were fed with a corn-soybean meal-based diet supplemented with 0 or 15 mg/kg db-cAMP, and both experiments lasted 35 days, respectively.
  
  
  RESULTS
  The results showed that db-cAMP decreased the backfat thickness, backfat percentage, and diameter of backfat cells without changing the growth performance or carcass characteristics in both experiments, and this effect was more marked in experiment 1 than in experiment 2; db-cAMP enhanced the activity of the growth hormone-insulin-like growth factor-1 (GH-IGF-1) axis and pro-opiomelanocortin (POMC) system in both experiments, which suppressed the accumulation of backfat deposition; microarray analysis showed that db-cAMP suppressed the inflammatory system within the adipose tissue related to insulin sensitivity, which also reduced fat synthesis.
  
  
  CONCLUSIONS
  In summary, the effect of db-cAMP on suppressing fat synthesis and accumulation is better in the earlier phase than in the later phase of finishing pigs, and db-cAMP plays this function by increasing the activity of the GH-IGF-1 axis and POMC system, while decreasing the inflammatory system within the adipose tissue related to insulin sensitive or lipolysis.
authors.affiliation: Institute of Animal Science, Guangdong Academy of Agricultural Sciences, 510640 Guangzhou, China ; The Key Laboratory of Animal Nutrition and Feed Science (South China) of Ministry of Agriculture, 510640 Guangzhou, China ; State Key Laboratory of Livestock and Poultry Breeding, 510640 Guangzhou, China ; Guangdong Public Laboratory of Animal Breeding and Nutrition, 510640 Guangzhou, China ; Guangdong Key Laboratory of Animal Breeding and Nutrition, 510640 Guangzhou, China.
authors.forename: Xianyong
authors.initials: X
authors.lastname: Ma
authors.affiliation: Institute of Animal Science, Guangdong Academy of Agricultural Sciences, 510640 Guangzhou, China ; The Key Laboratory of Animal Nutrition and Feed Science (South China) of Ministry of Agriculture, 510640 Guangzhou, China ; State Key Laboratory of Livestock and Poultry Breeding, 510640 Guangzhou, China ; Guangdong Public Laboratory of Animal Breeding and Nutrition, 510640 Guangzhou, China ; Guangdong Key Laboratory of Animal Breeding and Nutrition, 510640 Guangzhou, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Fang
authors.affiliation: Institute of Animal Science, Guangdong Academy of Agricultural Sciences, 510640 Guangzhou, China ; The Key Laboratory of Animal Nutrition and Feed Science (South China) of Ministry of Agriculture, 510640 Guangzhou, China ; State Key Laboratory of Livestock and Poultry Breeding, 510640 Guangzhou, China ; Guangdong Public Laboratory of Animal Breeding and Nutrition, 510640 Guangzhou, China ; Guangdong Key Laboratory of Animal Breeding and Nutrition, 510640 Guangzhou, China.
authors.forename: Zongyong
authors.initials: Z
authors.lastname: Jiang
authors.affiliation: Institute of Animal Science, Guangdong Academy of Agricultural Sciences, 510640 Guangzhou, China ; The Key Laboratory of Animal Nutrition and Feed Science (South China) of Ministry of Agriculture, 510640 Guangzhou, China ; State Key Laboratory of Livestock and Poultry Breeding, 510640 Guangzhou, China ; Guangdong Public Laboratory of Animal Breeding and Nutrition, 510640 Guangzhou, China ; Guangdong Key Laboratory of Animal Breeding and Nutrition, 510640 Guangzhou, China.
authors.forename: Li
authors.initials: L
authors.lastname: Wang
authors.affiliation: Institute of Animal Science, Guangdong Academy of Agricultural Sciences, 510640 Guangzhou, China ; The Key Laboratory of Animal Nutrition and Feed Science (South China) of Ministry of Agriculture, 510640 Guangzhou, China ; State Key Laboratory of Livestock and Poultry Breeding, 510640 Guangzhou, China ; Guangdong Public Laboratory of Animal Breeding and Nutrition, 510640 Guangzhou, China ; Guangdong Key Laboratory of Animal Breeding and Nutrition, 510640 Guangzhou, China.
authors.forename: Xuefen
authors.initials: X
authors.lastname: Yang
authors.affiliation: Institute of Animal Science, Guangdong Academy of Agricultural Sciences, 510640 Guangzhou, China ; The Key Laboratory of Animal Nutrition and Feed Science (South China) of Ministry of Agriculture, 510640 Guangzhou, China ; State Key Laboratory of Livestock and Poultry Breeding, 510640 Guangzhou, China ; Guangdong Public Laboratory of Animal Breeding and Nutrition, 510640 Guangzhou, China ; Guangdong Key Laboratory of Animal Breeding and Nutrition, 510640 Guangzhou, China.
authors.forename: Kaiguo
authors.initials: K
authors.lastname: Gao
keywords: Adipocyte cell; Backfat thickness; Endocrine system; Gene microarray; Inflammatory system