title: Long-Term Clinical Outcomes in Diabetic Rhesus Macaques (Macaca mulatta) Treated with Medroxyprogesterone Acetate for Endometriosis.
abstract: Depot medroxyprogesterone acetate (DMPA) is a common medical treatment for endometriosis in NHP. Because DMPA reportedly impairs glucoregulatory function in humans and rhesus macaques, as well as predisposes humans to diabetes mellitus (DM), we performed a retrospective study to further investigate its potential long-term clinical effects in animals with and without DM. Using a cohort of 29 rhesus macaques, we explored the hypotheses that DMPA treatment accelerates the onset of DM and that its use in rhesus macaques with endometriosis worsens clinical outcome measures (lifespan, body weight and body condition score). For both body weight and body condition score, a declining and statistically significant trend in mean values was evident as macaques developed either DM, or endometriosis or both. The addition of DMPA did not significantly alter this pattern. The presence of DM, endometriosis, or DMPA treatment statistically but not clinically significantly increased risk of death. Similarly, the presence of the 2 highly correlated variables endometriosis and DMPA treatment statistically but not clinically significantly increased the risk of incident DM. These results indicate that DMPA treatment was associated with worsening trends in lifespan and incident DM, however these trends did not achieve clinical significance in this cohort.
authors.affiliation: Division of Veterinary Resources, NIH, Bethesda, Maryland, USA; meghan.connolly@nih.gov.
authors.forename: Meghan A
authors.initials: MA
authors.lastname: Connolly
authors.affiliation: Yale Program on Aging, Biostatistics Core, Yale University, New Haven, Connecticut, USA.
authors.forename: Mark
authors.initials: M
authors.lastname: Trentalange
authors.affiliation: Section of Comparative Medicine, Yale University, New Haven, Connecticut, USA.
authors.forename: Caroline J
authors.initials: CJ
authors.lastname: Zeiss
mesh_terms: D000818:Animals; D003692:Delayed-Action Preparations; D048909:Diabetes Complications / Q000188:drug therapy / Q000662:veterinary*; D004715:Endometriosis / Q000150:complications / Q000188:drug therapy / Q000662:veterinary*; D005260:Female; D008253:Macaca mulatta; D017258:Medroxyprogesterone Acetate / Q000008:administration & dosage / Q000009:adverse effects*; D008992:Monkey Diseases / Q000188:drug therapy*; D012189:Retrospective Studies; D016896:Treatment Outcome
chemical_list: D003692:Delayed-Action Preparations; D017258:Medroxyprogesterone Acetate