title: Subversion of host genome integrity by bacterial pathogens.
abstract: Mammalian cells possess sophisticated genome surveillance and repair mechanisms, executed by the so-called DNA damage response (DDR), failure of which leads to accumulation of DNA damage and genomic instability. Mounting evidence suggests that bacterial infections can elicit DNA damage in host cells, and certain pathogens induce such damage as part of their multi-faceted infection programme. Bacteria-mediated DNA damage can occur either directly through the formation of toxins with genotoxic activities or indirectly as a result of the activation of cell-autonomous or immune defence mechanisms against the pathogen. Moreover, host-cell signalling routes involved in the DDR can be altered in response to an infection, and this, in the context of DNA damage elicited by the pathogen, has the potential to trigger mutations and cancer.
authors.affiliation: Department of Molecular Biology, Max Planck Institute for Infection Biology, Charitèplatz 1, 10117 Berlin, Germany.
authors.forename: Cindrilla
authors.initials: C
authors.lastname: Chumduri
authors.affiliation: Department of Molecular Biology, Max Planck Institute for Infection Biology, Charitèplatz 1, 10117 Berlin, Germany.
authors.forename: Rajendra Kumar
authors.initials: RK
authors.lastname: Gurumurthy
authors.affiliation: Department of Molecular Biology, Max Planck Institute for Infection Biology, Charitèplatz 1, 10117 Berlin, Germany.
authors.forename: Rike
authors.initials: R
authors.lastname: Zietlow
authors.affiliation: Department of Molecular Biology, Max Planck Institute for Infection Biology, Charitèplatz 1, 10117 Berlin, Germany.
authors.forename: Thomas F
authors.initials: TF
authors.lastname: Meyer
mesh_terms: D000818:Animals; D001424:Bacterial Infections / Q000235:genetics / Q000382:microbiology*; D002692:Chlamydia trachomatis / Q000502:physiology; D004249:DNA Damage; D004260:DNA Repair; D015894:Genome, Human; D042822:Genomic Instability; D016480:Helicobacter pylori / Q000502:physiology; D054884:Host-Pathogen Interactions; D006801:Humans; D010455:Peptides / Q000502:physiology; D061065:Polyketides; D012763:Shigella flexneri / Q000502:physiology
chemical_list: D010455:Peptides; D061065:Polyketides; C569566:colibactin