title: Hierarchically Staggered Nanostructure of Mineralized Collagen as a Bone-Grafting Scaffold.
abstract: A hierarchical, intrafibrillarly mineralized collagen (HIMC) is achieved through a selective mineralization progress in the collagenous gap regions mediated by poly(acrylic acid) with appropriate molecular weight. The associated topographical features directly correlate with nanomechanical heterogeneities of the HIMC to accommodate a broad range of external loads. Moreover, this hierarchically staggered nanostructure provides an optimized microenvironment to improve bone regeneration by instructing host cells.
authors.affiliation: Center for Craniofacial Stem Cell Research and Regeneration, Department of Orthodontics, Peking University School and Hospital of Stomatology, National Engineering Laboratory for Digital and Material Technology of Stomatology, Beijing Key Laboratory of Digital Stomatology, Beijing, 100081, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Center for Craniofacial Stem Cell Research and Regeneration, Department of Orthodontics, Peking University School and Hospital of Stomatology, National Engineering Laboratory for Digital and Material Technology of Stomatology, Beijing Key Laboratory of Digital Stomatology, Beijing, 100081, China.
authors.forename: Shuai
authors.initials: S
authors.lastname: Liu
authors.affiliation: Beijing National Laboratory for Molecular Sciences, Key Laboratory of Analytical Chemistry for Living Biosystems, Institute of Chemistry, The Chinese Academy of Sciences, Beijing, 100190, China.|State Key Laboratory of Heavy Oil Processing, Institute of New Energy, China University of Petroleum (Beijing), Beijing, 102249, China.
authors.forename: Dan
authors.initials: D
authors.lastname: Luo
authors.affiliation: Beijing National Laboratory for Molecular Sciences, Key Laboratory of Analytical Chemistry for Living Biosystems, Institute of Chemistry, The Chinese Academy of Sciences, Beijing, 100190, China.
authors.forename: Zhenjie
authors.initials: Z
authors.lastname: Xue
authors.affiliation: Institute of Physics, Chinese Academy of Sciences, Beijing, 100190, China.
authors.forename: Xinan
authors.initials: X
authors.lastname: Yang
authors.affiliation: Institute of Physics, Chinese Academy of Sciences, Beijing, 100190, China.
authors.forename: Lin
authors.initials: L
authors.lastname: Gu
authors.affiliation: Center for Craniofacial Stem Cell Research and Regeneration, Department of Orthodontics, Peking University School and Hospital of Stomatology, National Engineering Laboratory for Digital and Material Technology of Stomatology, Beijing Key Laboratory of Digital Stomatology, Beijing, 100081, China. yanhengzhou@gmail.com.
authors.forename: Yanheng
authors.initials: Y
authors.lastname: Zhou
authors.affiliation: Beijing National Laboratory for Molecular Sciences, Key Laboratory of Analytical Chemistry for Living Biosystems, Institute of Chemistry, The Chinese Academy of Sciences, Beijing, 100190, China. wangtie@iccas.ac.cn.
authors.forename: Tie
authors.initials: T
authors.lastname: Wang
mesh_terms: D001861:Bone Regeneration; D003094:Collagen; D049329:Nanostructures; D023822:Tissue Engineering
chemical_list: D003094:Collagen
keywords: bone regeneration; intrafibrillar mineralization; staggered nanostructures; stem cells