title: Intravascular emboli is an independent risk factor for the prognosis of stage III colorectal cancer patients after radical surgery.
abstract: Lymphovascular emboli is a prognostic factor in stage II CRC, but the significance of intravascular emboli (IVE) in stage III is unclear. Data from consecutive stage III CRC patients receiving radical surgery between January 2009 and November 2014 were retrospectively collected. The expression of CD133 was tested by immumohistochemical (IHC) staining. The potential prognosis risk factors were tested using univariate and multivariate survival analyses. IVE was significantly associated with CD133 expression (P < 0.001), gross tumor morphology (P = 0.001), histologic type (p < 0.001), lymph node status (pN) (p < 0.001), sub-class of stage III (p = 0.001), and serum CA199 level (p = 0.022). IVE, CD133 expression and lymph node status (pN) were independent risk factors for overall survival (OS) (p < 0.001, p = 0.003, and p = 0.008, respectively) and disease-free survival (DFS) (p < 0.001, p = 0.004, and p = 0.007, respectively) in stage III CRC. IVE might be an independent risk factor for the prognosis of stage III CRC patients after radical surgery. IVE might express a cancer stem cell (CSC) phenotype.
authors.affiliation: Department of Gastrointestinal Surgery, Xiangya Hospital, Central South University, Changsha, China.
authors.forename: Qian
authors.initials: Q
authors.lastname: Pei
authors.affiliation: Department of Oncology, Xiangya Hospital, Central South University, Changsha, China.
authors.forename: Hong
authors.initials: H
authors.lastname: Zhu
authors.affiliation: Department of Gastrointestinal Surgery, Xiangya Hospital, Central South University, Changsha, China.
authors.forename: Fengbo
authors.initials: F
authors.lastname: Tan
authors.affiliation: Department of Gastrointestinal Surgery, Xiangya Hospital, Central South University, Changsha, China.
authors.forename: Nanhui
authors.initials: N
authors.lastname: Yu
authors.affiliation: Department of Gastrointestinal Surgery, Xiangya Hospital, Central South University, Changsha, China.
authors.forename: Zhongyi
authors.initials: Z
authors.lastname: Zhou
authors.affiliation: Department of Gastrointestinal Surgery, Xiangya Hospital, Central South University, Changsha, China.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Zhou
authors.affiliation: Department of Gastrointestinal Surgery, Xiangya Hospital, Central South University, Changsha, China.
authors.forename: Xiangping
authors.initials: X
authors.lastname: Song
authors.affiliation: Department of Gastrointestinal Surgery, Xiangya Hospital, Central South University, Changsha, China.
authors.forename: Yuqiang
authors.initials: Y
authors.lastname: Li
authors.affiliation: Department of General Surgery, Xiangya Hospital, Central South University, Changsha, China.
authors.forename: Yiming
authors.initials: Y
authors.lastname: Tao
authors.affiliation: Institute of Medical Sciences, Xiangya Hospital, Central South University, Changsha, China.
authors.forename: Sai
authors.initials: S
authors.lastname: Zhang
authors.affiliation: Department of Pathology, Xiangya Hospital, Central South University, Changsha, China.
authors.forename: Liling
authors.initials: L
authors.lastname: Li
authors.affiliation: Department of Pathology, Xiangya Hospital, Central South University, Changsha, China.
authors.forename: Qingling
authors.initials: Q
authors.lastname: Li
authors.affiliation: Department of Gastrointestinal Surgery, Xiangya Hospital, Central South University, Changsha, China.
authors.forename: Haiping
authors.initials: H
authors.lastname: Pei
mesh_terms: D000071916:AC133 Antigen / Q000378:metabolism; D000368:Aged; D014408:Biomarkers, Tumor / Q000235:genetics; D015179:Colorectal Neoplasms / Q000150:complications / Q000175:diagnosis / Q000601:surgery*; D018572:Disease-Free Survival; D004617:Embolism / Q000150:complications* / Q000175:diagnosis; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009367:Neoplasm Staging; D014411:Neoplastic Stem Cells / Q000473:pathology; D011379:Prognosis; D012189:Retrospective Studies; D012307:Risk Factors
chemical_list: D000071916:AC133 Antigen; D014408:Biomarkers, Tumor; C000606023:PROM1 protein, human
keywords: CD133; clinicopathological characteristics; intravascular emboli; prognosis; stage III colorectal cancer