title: A novel pyrrole alkaloid from the fruit peels of Strychnos nux-blanda.
abstract: A novel pyrrole alkaloid, strychnuxin (1), along with five known compounds (2-6) was isolated from the fruit peels of Strychnos nux-blanda. The structures of all the isolated compounds (1-6) were fully characterised using spectroscopic data, as well as comparison with the previous literature data. Moreover, all isolated compounds were assessed for their α-glucosidase and acetylcholinesterase inhibitory activities.
authors.affiliation: a Natural Products Research Unit, Faculty of Science, Department of Chemistry , Chulalongkorn University , Bangkok , Thailand.
authors.forename: Jirapast
authors.initials: J
authors.lastname: Sichaem
authors.affiliation: b Faculty of Pharmaceutical Sciences, Department of Pharmaceutical Chemistry and Pharmacognosy , Naresuan University , Phitsanulok , Thailand.
authors.forename: Kornkanok
authors.initials: K
authors.lastname: Ingkaninan
authors.affiliation: a Natural Products Research Unit, Faculty of Science, Department of Chemistry , Chulalongkorn University , Bangkok , Thailand.
authors.forename: Santi
authors.initials: S
authors.lastname: Tip-Pyang
mesh_terms: D002800:Cholinesterase Inhibitors / Q000737:chemistry / Q000494:pharmacology; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000494:pharmacology; D005638:Fruit / Q000737:chemistry*; D010936:Plant Extracts / Q000737:chemistry; D011758:Pyrroles / Q000737:chemistry* / Q000494:pharmacology*; D012639:Seeds / Q000737:chemistry; D021241:Spectrometry, Mass, Electrospray Ionization; D013056:Spectrophotometry, Ultraviolet; D031451:Strychnos / Q000737:chemistry*; D013785:Thailand; D000520:alpha-Glucosidases
chemical_list: D002800:Cholinesterase Inhibitors; D004791:Enzyme Inhibitors; D010936:Plant Extracts; D011758:Pyrroles; C000617916:strychnuxin; D000520:alpha-Glucosidases
keywords: Loganiaceae; Strychnos nux-blanda; antiacetylcholinesterase activity; pyrrole alkaloid; α-glucosidase inhibitory activity