title: Stroke induces specific alteration of T memory compartment controlling auto-reactive CNS antigen-specific T cell responses.
abstract: Whether and when auto-reactivity after stroke occurs is still a matter of debate. By using overlapping 15mer peptide pools consisting of myelin basic protein (MBP) and myelin oligodendrocyte glycoprotein (MOG) we show increased frequencies of immunodominant MOG- and MBP T cell responses in acute ischemic stroke which were associated with reduced frequencies of naïve T cells as well as CD8+ TEMRA cells. Auto-reactive CNS antigen-specific T cells responses as well as alterations of T cell subpopulations normalized in long-term follow up after stroke. Our findings suggest that stroke-induced immunodepression might function as an adaptive mechanism in order to inhibit harmful and long-lasting CNS antigen-specific immune responses.
authors.affiliation: Department of Neurology (JK, SH, and AM), Charité Universitaetsmedizin, Charitéplatz 1, Berlin, Germany. Electronic address: juliane.klehmet@charite.de.
authors.forename: Juliane
authors.initials: J
authors.lastname: Klehmet
authors.affiliation: Department of Neurology (JK, SH, and AM), Charité Universitaetsmedizin, Charitéplatz 1, Berlin, Germany. Electronic address: sarah.hoffmann@charite.de.
authors.forename: Sarah
authors.initials: S
authors.lastname: Hoffmann
authors.affiliation: Department of Orthopedics, Helios Klinikum Buch, Schwanebecker Chaussee 50, Berlin, Germany. Electronic address: gerrit.walter@helioskliniken.de.
authors.forename: Gerrit
authors.initials: G
authors.lastname: Walter
authors.affiliation: Department of Medical Immunology (CM), Charité Universitaetsmedizin, Berlin, Germany; Department of Immunology (CM), Labor Berlin Charité Vivantes, Sylter Strasse 2, Berlin, Germany. Electronic address: christian.meisel@laborberlin.com.
authors.forename: Christian
authors.initials: C
authors.lastname: Meisel
authors.affiliation: Department of Neurology (JK, SH, and AM), Charité Universitaetsmedizin, Charitéplatz 1, Berlin, Germany. Electronic address: andreas.meisel@charite.de.
authors.forename: Andreas
authors.initials: A
authors.lastname: Meisel
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015551:Autoimmunity; D002545:Brain Ischemia / Q000276:immunology* / Q000628:therapy; D058501:Enzyme-Linked Immunospot Assay; D005260:Female; D005434:Flow Cytometry; D005500:Follow-Up Studies; D006801:Humans; D007156:Immunologic Memory; D007371:Interferon-gamma / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D004676:Myelin Basic Protein / Q000378:metabolism; D063308:Myelin-Oligodendrocyte Glycoprotein / Q000378:metabolism; D015213:Neuroimmunomodulation; D020521:Stroke / Q000276:immunology* / Q000628:therapy; D016176:T-Lymphocyte Subsets / Q000276:immunology*
chemical_list: C499048:MBP protein, human; C571326:MOG protein, human; D004676:Myelin Basic Protein; D063308:Myelin-Oligodendrocyte Glycoprotein; D007371:Interferon-gamma
keywords: Auto-reactive T cell; MBP; MOG; Stroke; T memory cell