title: ER-Mitochondria contact sites: A new regulator of cellular calcium flux comes into play.
abstract: Endoplasmic reticulum (ER)-mitochondria membrane contacts are hotspots for calcium signaling. In this issue, Raturi et al. (2016. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201512077) show that the thioredoxin TMX1 inhibits the calcium pump SERCA2b at ER-mitochondria contact sites, thereby affecting ER-mitochondrial calcium transfer and mitochondrial bioenergetics.
authors.affiliation: Peripheral Neuropathy Group, VIB Department of Molecular Genetics, University of Antwerp, 2610 Antwerpen, Belgium Neurogenetics Laboratory, Institute Born-Bunge, 2610 Antwerpen, Belgium.
authors.forename: Michiel
authors.initials: M
authors.lastname: Krols
authors.affiliation: Laboratory of Molecular and Cellular Signaling, Department of Cellular and Molecular Medicine, KU Leuven, 3000 Leuven, Belgium Leuvens Kankerinstituut, KU Leuven, 3000 Leuven, Belgium.
authors.forename: Geert
authors.initials: G
authors.lastname: Bultynck
authors.affiliation: Immunoregulation and Mucosal Immunology Unit, Inflammation Research Center, VIB-UGent, BE-9030 Ghent, Belgium Department of Internal Medicine, Universiteit Gent, BE-9030 Ghent, Belgium sophie.janssens@irc.vib-ugent.be.
authors.forename: Sophie
authors.initials: S
authors.lastname: Janssens
mesh_terms: D000818:Animals; D002118:Calcium / Q000378:metabolism*; D020013:Calcium Signaling; D004721:Endoplasmic Reticulum / Q000378:metabolism*; D006801:Humans; D008928:Mitochondria / Q000378:metabolism*; D008954:Models, Biological; D010084:Oxidation-Reduction
chemical_list: D002118:Calcium