title: Translating the Science of Psoriasis.
abstract: Knowledge about the pathophysiology of psoriasis has evolved substantially in recent years, since the identification of the T helper 17 (Th17) cells. Cytokines produced by these cells appear to play major roles in psoriatic inflammation. The cytokine interleukin (IL)-23 appears to promote regulatory T cells to differentiate into Th17 cells. Available and investigational therapies act on targets within these pathways.
authors.affiliation: Professor of Dermatology Northwestern University Feinberg School of Medicine Chicago, Illinois.
authors.forename: Kenneth B
authors.initials: KB
authors.lastname: Gordon
mesh_terms: D015415:Biomarkers / Q000097:blood; D003879:Dermatologic Agents / Q000008:administration & dosage*; D006801:Humans; D053759:Interleukin-23 / Q000276:immunology*; D011565:Psoriasis / Q000097:blood / Q000188:drug therapy* / Q000276:immunology* / Q000503:physiopathology; D058504:Th17 Cells / Q000276:immunology*; D016896:Treatment Outcome; D000069549:Ustekinumab / Q000008:administration & dosage*
chemical_list: D015415:Biomarkers; D003879:Dermatologic Agents; D053759:Interleukin-23; D000069549:Ustekinumab
keywords: IL-17; IL-23; Psoriasis treatment; Th17 pathway