title: Deregulated FADD expression and phosphorylation in T-cell lymphoblastic lymphoma.
abstract: In the present work, we show that T-cell lymphoblastic lymphoma cells exhibit a reduction of FADD availability in the cytoplasm, which may contribute to impaired apoptosis. In addition, we observe a reduction of FADD phosphorylation that inversely correlates with the proliferation capacity and tumor aggressiveness. The resultant balance between FADD-dependent apoptotic and non-apoptotic abilities may define the outcome of the tumor. Thus, we propose that FADD expression and phosphorylation can be reliable biomarkers with prognostic value for T-LBL stratification.
authors.affiliation: Centro de Biología Molecular Severo Ochoa (CBMSO), Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid (CSIC-UAM), Madrid, Spain.|IIS-Fundación Jiménez Díaz, Madrid, Spain.|Universidad Autónoma de Madrid, Departamento de Biología, Madrid, Spain.
authors.forename: José L
authors.initials: JL
authors.lastname: Marín-Rubio
authors.affiliation: Universidad Carlos III, Departamento de Bioingeniería, Madrid, Spain.|Centro de Investigaciones Energéticas, Medioambientales y Tecnológicas (CIEMAT), Madrid, Spain.
authors.forename: María C
authors.initials: MC
authors.lastname: de Arriba
authors.affiliation: Centro de Biología Molecular Severo Ochoa (CBMSO), Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid (CSIC-UAM), Madrid, Spain.|IIS-Fundación Jiménez Díaz, Madrid, Spain.
authors.forename: María A
authors.initials: MA
authors.lastname: Cobos-Fernández
authors.affiliation: Centro de Biología Molecular Severo Ochoa (CBMSO), Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid (CSIC-UAM), Madrid, Spain.|IIS-Fundación Jiménez Díaz, Madrid, Spain.|Centro de Investigaciones Biomédicas en Red de Enfermedades Raras (CIBERER), Valencia, Spain.
authors.forename: Laura
authors.initials: L
authors.lastname: González-Sánchez
authors.affiliation: Universidad Autónoma de Madrid, Departamento de Biología, Madrid, Spain.
authors.forename: Inmaculada
authors.initials: I
authors.lastname: Ors
authors.affiliation: Centro de Biología Molecular Severo Ochoa (CBMSO), Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid (CSIC-UAM), Madrid, Spain.
authors.forename: Isabel
authors.initials: I
authors.lastname: Sastre
authors.affiliation: Centro de Biología Molecular Severo Ochoa (CBMSO), Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid (CSIC-UAM), Madrid, Spain.|IIS-Fundación Jiménez Díaz, Madrid, Spain.|Universidad Autónoma de Madrid, Departamento de Biología, Madrid, Spain.|Centro de Investigaciones Biomédicas en Red de Enfermedades Raras (CIBERER), Valencia, Spain.
authors.forename: José
authors.initials: J
authors.lastname: Fernández-Piqueras
authors.affiliation: Centro de Biología Molecular Severo Ochoa (CBMSO), Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid (CSIC-UAM), Madrid, Spain.|IIS-Fundación Jiménez Díaz, Madrid, Spain.|Universidad Autónoma de Madrid, Departamento de Biología, Madrid, Spain.|Centro de Investigaciones Biomédicas en Red de Enfermedades Raras (CIBERER), Valencia, Spain.
authors.forename: María
authors.initials: M
authors.lastname: Villa-Morales
mesh_terms: D000818:Animals; D017209:Apoptosis; D014408:Biomarkers, Tumor / Q000235:genetics / Q000378:metabolism*; D048128:Casein Kinase Ialpha / Q000378:metabolism; D049109:Cell Proliferation; D003593:Cytoplasm / Q000378:metabolism; D018076:DNA, Complementary / Q000235:genetics / Q000302:isolation & purification; D015536:Down-Regulation; D054637:Dual-Specificity Phosphatases / Q000378:metabolism; D053200:Fas-Associated Death Domain Protein / Q000235:genetics / Q000378:metabolism*; D005260:Female; D020869:Gene Expression Profiling; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D007150:Immunohistochemistry; D047908:Intracellular Signaling Peptides and Proteins / Q000378:metabolism; D019169:Jurkat Cells; D053208:Kaplan-Meier Estimate; D007942:Leukemia, Experimental / Q000235:genetics / Q000401:mortality / Q000473:pathology; D051379:Mice; D008810:Mice, Inbred C57BL; D054639:Mitogen-Activated Protein Kinase Phosphatases / Q000378:metabolism; D010766:Phosphorylation; D054218:Precursor T-Cell Lymphoblastic Leukemia-Lymphoma / Q000235:genetics* / Q000401:mortality / Q000473:pathology*; D011379:Prognosis; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism; D018570:Risk Assessment / Q000379:methods; D017422:Sequence Analysis, DNA; D012694:Serine / Q000378:metabolism; D060168:Thymocytes / Q000378:metabolism / Q000473:pathology; D015854:Up-Regulation
chemical_list: D014408:Biomarkers, Tumor; D018076:DNA, Complementary; C505533:FADD protein, human; D053200:Fas-Associated Death Domain Protein; D047908:Intracellular Signaling Peptides and Proteins; D012694:Serine; D048128:Casein Kinase Ialpha; C109102:HIPK3 protein, human; D017346:Protein Serine-Threonine Kinases; D054639:Mitogen-Activated Protein Kinase Phosphatases; C500883:DUSP26 protein, human; D054637:Dual-Specificity Phosphatases
keywords: Fas-associated death domain protein (FADD); T-cell lymphoblastic lymphoma; expression and phosphorylation; prognostic marker; tumor aggressiveness