title: Prognostic Value of Secretoneurin in Patients with Acute Respiratory Failure: Data from the FINNALI Study.
abstract: We examined whether secretoneurin (SN), a biomarker associated with cardiomyocyte Ca(2+) handling, provides prognostic information in patients with acute respiratory failure (ARF).
  
  
  
  We included 490 patients with ARF, defined as ventilatory support >6 h, with blood samples available on admission to the intensive care unit (ICU). SN concentrations were measured by RIA.
  
  
  
  A total of 209 patients (43%) were hospitalized with cardiovascular (CV)-related ARF, and 90-day mortality rates were comparable between CV- and non-CV-related ARF (n = 281): 31% vs 24%, P = 0.11. Admission SN concentrations were higher in nonsurvivors than in survivors in both CV-related (median 148 [quartile 1-3, 117-203] vs 108 [87-143] pmol/L, P < 0.001) and non-CV-related ARF (139 [115-184] vs 113 [91-139] pmol/L, P < 0.001). In patients with CV-related ARF, SN concentrations on ICU admission were associated with 90-day mortality [odds ratio (OR) 1.97 (95% CI, 1.04-3.73, P = 0.04)] after adjusting for established risk indices, including N-terminal-pro-B-type natriuretic peptide (NT-proBNP) concentrations. SN also improved patient classification in CV-related ARF as assessed by the net reclassification index: 0.32 (95% CI, 0.04-0.59), P = 0.03. The area under the curve (AUC) of SN to predict mortality in patients with CV-related ARF was 0.72 (95% CI, 0.65-0.79), and the AUC of NT-proBNP was 0.64 (0.56-0.73). In contrast, SN concentrations on ICU admission did not provide incremental prognostic value to established risk indices in patients with non-CV-related ARF, and the AUC was 0.67 (0.60-0.75).
  
  
  
  SN concentrations measured on ICU admission provided incremental prognostic information to established risk indices in patients with CV-related ARF, but not in patients with non-CV-related ARF.
authors.affiliation: Division of Medicine, Akershus University Hospital, Lørenskog, Norway and Center for Heart Failure Research, University of Oslo, Oslo, Norway; Center for Clinical Heart Research, Oslo University Hospital Ullevål, Oslo, Norway;
authors.forename: Peder L
authors.initials: PL
authors.lastname: Myhre
authors.affiliation: Division of Medicine, Akershus University Hospital, Lørenskog, Norway and Center for Heart Failure Research, University of Oslo, Oslo, Norway;
authors.forename: Anett H
authors.initials: AH
authors.lastname: Ottesen
authors.affiliation: Division of Intensive Care Medicine, Department of Anesthesiology, Intensive Care and Pain Medicine, University of Helsinki and Helsinki University Hospital, Helsinki, Finland;
authors.forename: Marjatta
authors.initials: M
authors.lastname: Okkonen
authors.affiliation: Division of Intensive Care Medicine, Department of Anesthesiology, Intensive Care and Pain Medicine, University of Helsinki and Helsinki University Hospital, Helsinki, Finland;
authors.forename: Rita
authors.initials: R
authors.lastname: Linko
authors.affiliation: Department of Medical Sciences, Uppsala University, Uppsala, Sweden;
authors.forename: Mats
authors.initials: M
authors.lastname: Stridsberg
authors.affiliation: Bioinformatics Core Facility, Oslo University Hospital and the University of Oslo, Oslo, Norway;
authors.forename: Ståle
authors.initials: S
authors.lastname: Nygård
authors.affiliation: Institute for Experimental Medical Research, Oslo University Hospital, Ullevål, Oslo, Norway and Center for Heart Failure Research, University of Oslo, Oslo, Norway;
authors.forename: Geir
authors.initials: G
authors.lastname: Christensen
authors.affiliation: Division of Intensive Care Medicine, Department of Anesthesiology, Intensive Care and Pain Medicine, University of Helsinki and Helsinki University Hospital, Helsinki, Finland; Department of Intensive Care Medicine, Bern University Hospital, University of Bern, Bern, Switzerland.
authors.forename: Ville
authors.initials: V
authors.lastname: Pettilä
authors.affiliation: Division of Medicine, Akershus University Hospital, Lørenskog, Norway and Center for Heart Failure Research, University of Oslo, Oslo, Norway;
authors.forename: Torbjørn
authors.initials: T
authors.lastname: Omland
authors.affiliation: Division of Medicine, Akershus University Hospital, Lørenskog, Norway and Center for Heart Failure Research, University of Oslo, Oslo, Norway; helge.rosjo@medisin.uio.no.
authors.forename: Helge
authors.initials: H
authors.lastname: Røsjø
mesh_terms: D000208:Acute Disease; D000368:Aged; D015415:Biomarkers / Q000097:blood; D005260:Female; D006801:Humans; D007362:Intensive Care Units; D008297:Male; D008875:Middle Aged; D009479:Neuropeptides / Q000097:blood*; D011379:Prognosis; D012131:Respiratory Insufficiency / Q000097:blood* / Q000175:diagnosis*; D053381:Secretogranin II / Q000097:blood*
chemical_list: D015415:Biomarkers; D009479:Neuropeptides; D053381:Secretogranin II; C081159:secretoneurin