title: Review of thalamocortical resting-state fMRI studies in schizophrenia.
abstract: Brain circuitry underlying cognition, emotion, and perception is abnormal in schizophrenia. There is considerable evidence that the neuropathology of schizophrenia includes the thalamus, a key hub of cortical-subcortical circuitry and an important regulator of cortical activity. However, the thalamus is a heterogeneous structure composed of several nuclei with distinct inputs and cortical connections. Limitations of conventional neuroimaging methods and conflicting findings from post-mortem investigations have made it difficult to determine if thalamic pathology in schizophrenia is widespread or limited to specific thalamocortical circuits. Resting-state fMRI has proven invaluable for understanding the large-scale functional organization of the brain and investigating neural circuitry relevant to psychiatric disorders. This article summarizes resting-state fMRI investigations of thalamocortical functional connectivity in schizophrenia. Particular attention is paid to the course, diagnostic specificity, and clinical correlates of thalamocortical network dysfunction.
authors.affiliation: Department of Psychiatry & Behavioral Sciences, Vanderbilt University School of Medicine, Nashville, TN, United States.
authors.forename: Monica
authors.initials: M
authors.lastname: Giraldo-Chica
authors.affiliation: Department of Psychiatry & Behavioral Sciences, Vanderbilt University School of Medicine, Nashville, TN, United States. Electronic address: neil.woodward@vanderbilt.edu.
authors.forename: Neil D
authors.initials: ND
authors.lastname: Woodward
mesh_terms: D000818:Animals; D001931:Brain Mapping; D002540:Cerebral Cortex / Q000000981:diagnostic imaging / Q000503:physiopathology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D009434:Neural Pathways / Q000000981:diagnostic imaging / Q000503:physiopathology; D012146:Rest; D012559:Schizophrenia / Q000000981:diagnostic imaging / Q000503:physiopathology*; D013788:Thalamus / Q000000981:diagnostic imaging / Q000503:physiopathology*
keywords: Cortex; Resting-state fMRI; Schizophrenia; Thalamus