title: Non-Prostate-Specific Membrane Antigen-Avid Metastatic Lung Nodule From Primary Prostatic Adenocarcinoma.
abstract: Ga-prostate-specific membrane antigen (PSMA) PET/CT is increasingly used to evaluate recurrent prostatic malignancy due to its high specificity. A 56-year-old man with previous history of treated prostate cancer 4 years earlier presented with rising prostate-specific antigen level and underwent Ga-PSMA PET/CT, which demonstrated an enlarging pulmonary nodule without PSMA avidity. The pulmonary nodule, however, showed moderate uptake on a corresponding FDG PET/CT study, suspicious of primary lung malignancy. Cytological and histopathological examination of the pulmonary nodule confirmed a metastatic deposit from ductal prostatic adenocarcinoma, an uncommon variant of prostatic malignancy.
authors.affiliation: From the *Department of Nuclear Medicine and PET, Nepean Hospital, Penrith; †Nepean Medical School, University of Sydney, Sydney; and Departments of ‡Anatomical Pathology, and §Radiation Oncology, Nepean Hospital, Penrith, Australia.
authors.forename: Deepa
authors.initials: D
authors.lastname: Shetty
authors.forename: Han
authors.initials: H
authors.lastname: Loh
authors.forename: Chuong
authors.initials: C
authors.lastname: Bui
authors.forename: Robert
authors.initials: R
authors.lastname: Mansberg
authors.forename: Amirazin
authors.initials: A
authors.lastname: Hadjashrafi
authors.forename: Viet
authors.initials: V
authors.lastname: Do
mesh_terms: D000230:Adenocarcinoma / Q000000981:diagnostic imaging* / Q000473:pathology; D004492:Edetic Acid / Q000031:analogs & derivatives; D019788:Fluorodeoxyglucose F18; D005709:Gallium Isotopes; D005710:Gallium Radioisotopes; D006801:Humans; D008175:Lung Neoplasms / Q000000981:diagnostic imaging* / Q000556:secondary; D008297:Male; D008875:Middle Aged; D009842:Oligopeptides; D009942:Organometallic Compounds; D000072078:Positron Emission Tomography Computed Tomography; D011471:Prostatic Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology; D019275:Radiopharmaceuticals
chemical_list: D005709:Gallium Isotopes; D005710:Gallium Radioisotopes; D009842:Oligopeptides; D009942:Organometallic Compounds; D019275:Radiopharmaceuticals; C000718244:gallium 68 PSMA-11; D019788:Fluorodeoxyglucose F18; D004492:Edetic Acid