title: Complement-Mediated Regulation of Metabolism and Basic Cellular Processes.
abstract: Complement is well appreciated as a critical arm of innate immunity. It is required for the removal of invading pathogens and works by directly destroying them through the activation of innate and adaptive immune cells. However, complement activation and function is not confined to the extracellular space but also occurs within cells. Recent work indicates that complement activation regulates key metabolic pathways and thus can impact fundamental cellular processes, such as survival, proliferation, and autophagy. Newly identified functions of complement include a key role in shaping metabolic reprogramming, which underlies T cell effector differentiation, and a role as a nexus for interactions with other effector systems, in particular the inflammasome and Notch transcription-factor networks. This review focuses on the contributions of complement to basic processes of the cell, in particular the integration of complement with cellular metabolism and the potential implications in infection and other disease settings.
authors.affiliation: Department of Biomedicine, Immunobiology, University of Basel, 20 Hebelstrasse, 4031 Basel, Switzerland. Electronic address: chess@uhbs.ch.
authors.forename: Christoph
authors.initials: C
authors.lastname: Hess
authors.affiliation: Division of Transplant Immunology and Mucosal Biology, Medical Reseaerch Council Centre for Transplantation, King's College London, Guy's Hospital, Great Maze Pond, London SE1 9RT, UK; Laboratory of Molecular Immunology and the Immunology Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA. Electronic address: claudia.kemper@kcl.ac.uk.
authors.forename: Claudia
authors.initials: C
authors.lastname: Kemper
mesh_terms: D000818:Animals; D001343:Autophagy; D002454:Cell Differentiation; D049109:Cell Proliferation; D002470:Cell Survival; D065150:Cellular Reprogramming; D003165:Complement System Proteins / Q000378:metabolism*; D006801:Humans; D007113:Immunity, Innate; D007239:Infections / Q000276:immunology*; D058847:Inflammasomes / Q000378:metabolism; D042541:Intracellular Space; D051880:Receptors, Notch / Q000378:metabolism; D015398:Signal Transduction; D013601:T-Lymphocytes / Q000276:immunology*
chemical_list: D058847:Inflammasomes; D051880:Receptors, Notch; D003165:Complement System Proteins