title: Durable proteo-hybrid vesicles for the extended functional lifetime of membrane proteins in bionanotechnology.
abstract: The full capabilities of membrane proteins in bionanotechnology can only be realised through improvements in their reconstitution environments that combine biocompatibility to support function and durability for long term stability. We demonstrate that hybrid vesicles composed of natural phospholipids and synthetic diblock copolymers have the potential to achieve these criteria.
authors.affiliation: School of Chemistry and Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds, LS2 9JT, UK. p.a.beales@leeds.ac.uk.
authors.forename: Sanobar
authors.initials: S
authors.lastname: Khan
authors.forename: Mengqiu
authors.initials: M
authors.lastname: Li
authors.forename: Stephen P
authors.initials: SP
authors.lastname: Muench
authors.forename: Lars J C
authors.initials: LJ
authors.lastname: Jeuken
authors.forename: Paul A
authors.initials: PA
authors.lastname: Beales
mesh_terms: D001672:Biocompatible Materials / Q000737:chemistry / Q000378:metabolism; D020285:Cryoelectron Microscopy; D003573:Cytochrome b Group; D003580:Cytochromes / Q000737:chemistry / Q000378:metabolism; D000067493:Dynamic Light Scattering; D029968:Escherichia coli Proteins / Q000737:chemistry / Q000378:metabolism; D008565:Membrane Proteins / Q000737:chemistry / Q000378:metabolism*; D008823:Micelles; D036103:Nanotechnology; D010743:Phospholipids / Q000737:chemistry; D011108:Polymers / Q000737:chemistry; D012235:Rhodamines / Q000737:chemistry; D053835:Unilamellar Liposomes / Q000737:chemistry / Q000378:metabolism*
chemical_list: D001672:Biocompatible Materials; D003573:Cytochrome b Group; D003580:Cytochromes; D029968:Escherichia coli Proteins; D008565:Membrane Proteins; D008823:Micelles; D010743:Phospholipids; D011108:Polymers; D012235:Rhodamines; D053835:Unilamellar Liposomes; C083850:cytochrome bo3, E coli