title: A Review on Plasmodium falciparum-Protein Farnesyltransferase Inhibitors as Antimalarial Drug Targets.
abstract: BACKGROUND
  Protein farnesyltransferase (PFT) inhibitors have emerged as a potent target for the malaria treatment caused by the Plasmodium falciparum (Pf) parasite.
  
  
  OBJECTIVE
  To explore the various scaffolds which are active against Pf-PFT target.
  
  
  RESULTS
  Seven inhibitor scaffolds based on ethylenediamine, peptidomimetic, benzophenone, benzamide, tetrahydroquinoline, naphthyridine and oxy-tetrahydroquinoline, have been developed till date.
  
  
  CONCLUSIONS
  It is concluded that naphthyridine based drugs are the most promising one. Furthermore, introducing the hydrophobic molecules like isoprenyl groups to a protein or a chemical compound facilitate protein-protein and protein-membrane interactions thereby makes them good candidates as new therapeutics. The future research should focus on the disease rather than the infection and the dynamics of its transmission; this will bring a new vision about the disease.
authors.affiliation: Department of Chemistry, Faculty of Physical Sciences, Shree Guru Gobind Singh Tricentenary University, Gurugram 122505, Haryana, India.
authors.forename: Kamlesh
authors.initials: K
authors.lastname: Sharma
mesh_terms: D019883:Alkyl and Aryl Transferases / Q000037:antagonists & inhibitors*; D000818:Animals; D000962:Antimalarials / Q000737:chemistry / Q000627:therapeutic use*; D055808:Drug Discovery; D006801:Humans; D016778:Malaria, Falciparum / Q000188:drug therapy* / Q000469:parasitology; D015394:Molecular Structure; D058990:Molecular Targeted Therapy; D009287:Naphthyridines / Q000737:chemistry / Q000627:therapeutic use*; D010963:Plasmodium falciparum / Q000187:drug effects* / Q000201:enzymology; D013329:Structure-Activity Relationship
chemical_list: D000962:Antimalarials; D009287:Naphthyridines; D019883:Alkyl and Aryl Transferases; C064911:p21(ras) farnesyl-protein transferase
keywords: Plasmodium falciparum; antimalarial; farnesyltransferase; inhibitor; protein