title: Constituents from the leaves of Clausena lansium and their anti-inflammatory activity.
abstract: Five new acyclic amides, clausenalansamides C-G (1-5), clausenaline G (6) and (±)-5-(4-methylphenyl)-γ-valerolactone (7) reported from the natural source for the first time, were characterized from the leaves of Clausena lansium. Their structures were established by spectroscopic and spectrometric methods, and the absolute configurations of new compounds 1-5 were determined by electronic circular dichroism and single-crystal X-ray diffraction analyses. Eighteen compounds were evaluated for their anti-inflammatory activity and only imperatorin (11) and wampetin (12) displayed significant inhibition of fMLP/CB-induced superoxide anion generation with IC50values of 1.7 ± 0.3 and 6.8 ± 1.1 μM, respectively.
authors.affiliation: School of Pharmacy, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, 701, Taiwan, ROC.
authors.forename: De-Yang
authors.initials: DY
authors.lastname: Shen
authors.affiliation: School of Pharmacy, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, 701, Taiwan, ROC.
authors.forename: Ping-Chung
authors.initials: PC
authors.lastname: Kuo
authors.affiliation: Department of Pharmacy, Chia-Nan University of Pharmacy and Science, Tainan, 71710, Taiwan, ROC.
authors.forename: Shiow-Chyn
authors.initials: SC
authors.lastname: Huang
authors.affiliation: Graduate Institute of Natural Products, College of Medicine, Chang Gung University, Taoyuan, 333, Taiwan, ROC.|Research Center for Industry of Human Ecology, Research Center for Chinese Herbal Medicine, and Graduate Institute of Health Industry Technology, College of Human Ecology, Chang Gung University of Science and Technology, Taoyuan, 333, Taiwan, ROC.|Department of Anesthesiology, Chang Gung Memorial Hospital, Taoyuan, 333, Taiwan, ROC.
authors.forename: Tsong-Long
authors.initials: TL
authors.lastname: Hwang
authors.affiliation: Department of Biotechnology, Southern Taiwan University of Science and Technology, Tainan, 71005, Taiwan.
authors.forename: Yu-Yi
authors.initials: YY
authors.lastname: Chan
authors.affiliation: Department of Pharmacy, Tajen University, Pingtung, 90741, Taiwan, ROC.
authors.forename: Po-Chuen
authors.initials: PC
authors.lastname: Shieh
authors.affiliation: Department of Chemistry, Vinh University, Vinh City, Vietnam.
authors.forename: Nguyen Thi
authors.initials: NT
authors.lastname: Ngan
authors.affiliation: Department of Chemistry, Vinh University, Vinh City, Vietnam.
authors.forename: Tran Dinh
authors.initials: TD
authors.lastname: Thang
authors.affiliation: School of Pharmacy, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, 701, Taiwan, ROC. tswu@mail.ncku.edu.tw.|Department of Pharmacy, Tajen University, Pingtung, 90741, Taiwan, ROC. tswu@mail.ncku.edu.tw.
authors.forename: Tian-Shung
authors.initials: TS
authors.lastname: Wu
mesh_terms: D000893:Anti-Inflammatory Agents / Q000737:chemistry* / Q000494:pharmacology; D054700:Clausena / Q000737:chemistry*; D015394:Molecular Structure; D018515:Plant Leaves / Q000737:chemistry*
chemical_list: D000893:Anti-Inflammatory Agents
keywords: Anti-inflammatory; Clausenalansamide; Electronic circular dichroism; Single-crystal X-ray diffraction analysis; Superoxide anion generation