title: Review of Critical Issues in the Pathogenesis of Atopic Dermatitis.
abstract: About a decade age, loss-of-function mutations in the filaggrin molecule were first implicated in the pathogenesis of ichthyosis vulgaris and, subsequently, of atopic dermatitis and other atopic diseases. Since then, intensive study of the role of filaggrin null mutations have led to other milestones in understanding the pathologic pathways in these diseases, including the initiation, maintenance, and promotion of the disease processes. The result has been new and emerging clinical and pharmacologic strategies for early identification of and intervention in atopic diseases. Semin Cutan Med Surg 35(supp5):S89-S91.
authors.affiliation: Professor of Dermatology Trinity College Dublin Attending Dermatologist Our Lady's Children's Hospital Crumlin St. James's Hospital Dublin, Ireland.
authors.forename: Alan D
authors.initials: AD
authors.lastname: Irvine
authors.affiliation: Professor of Dermatology and Pediatrics Chief, Pediatric and Adolescent Dermatology University of California San Diego School of Medicine Rady Children's Hospital San Diego, California.
authors.forename: Lawrence F
authors.initials: LF
authors.lastname: Eichenfield
authors.affiliation: Professor of Dermatology and Pediatrics University of California San Diego School of Medicine Fellowship Program Director Pediatric and Adolescent Dermatology Rady Children's Hospital San Diego, California.
authors.forename: Sheila F
authors.initials: SF
authors.lastname: Friedlander
authors.affiliation: Professor of Dermatology Director of Clinical Studies Oregon Health and Science University Department of Dermatology Portland, Oregon.
authors.forename: Eric L
authors.initials: EL
authors.lastname: Simpson
mesh_terms: D003876:Dermatitis, Atopic / Q000150:complications / Q000188:drug therapy / Q000235:genetics / Q000276:immunology; D004777:Environment; D000091344:Filaggrin Proteins; D005512:Food Hypersensitivity / Q000150:complications; D006801:Humans; D007381:Intermediate Filament Proteins / Q000235:genetics; D009154:Mutation
chemical_list: C000717249:FLG protein, human; D000091344:Filaggrin Proteins; D007381:Intermediate Filament Proteins
keywords: Atopic dermatitis; ILC2s; eczema; filaggrin null mutation; interleukin-13; interleukin-25; nuocytes; toll-like receptors; type 2 innate lymphoid cells