title: The role of amino acid-induced mammalian target of rapamycin complex 1(mTORC1) signaling in insulin resistance.
abstract: Mammalian target of rapamycin (mTOR) controls cell growth and metabolism in response to nutrients, energy, and growth factors. Recent findings have placed the lysosome at the core of mTOR complex 1 (mTORC1) regulation by amino acids. Two parallel pathways, Rag GTPase-Ragulator and Vps34-phospholipase D1 (PLD1), regulate mTOR activation on the lysosome. This review describes the recent advances in understanding amino acid-induced mTOR signaling with a particular focus on the role of mTOR in insulin resistance.
authors.affiliation: Department of Molecular Medicine, School of Medicine, Gachon University, Incheon, Korea.
authors.forename: Mee-Sup
authors.initials: MS
authors.lastname: Yoon
authors.affiliation: Department of Molecular Medicine, School of Medicine, Gachon University, Incheon, Korea.|Korea Mouse Metabolic Phenotyping Center (KMMPC), Lee Gil Ya Cancer and Diabetes Institute, Gachon University, Incheon, Korea.|Department of Endocrinology, Internal Medicine, Gachon University Gil Medical Center, Incheon, Korea.
authors.forename: Cheol Soo
authors.initials: CS
authors.lastname: Choi
mesh_terms: D000596:Amino Acids / Q000378:metabolism*; D000818:Animals; D006801:Humans; D007333:Insulin Resistance; D008247:Lysosomes / Q000378:metabolism; D000076222:Mechanistic Target of Rapamycin Complex 1 / Q000378:metabolism*; D010739:Phospholipase D / Q000378:metabolism; D015398:Signal Transduction
chemical_list: D000596:Amino Acids; D000076222:Mechanistic Target of Rapamycin Complex 1; D010739:Phospholipase D; C106801:phospholipase D1