title: Helicobacter pylori CagI is associated with the stability of CagA.
abstract: The type Ⅳ secretion system (T4SS) of H. pylori encoded by cag pathogenicity island mediates the injection of the toxin CagA, which is considered as a paradigm for bacterial carcinogenesis. T4SS is generally composed of a set of proteins, the majority of which still remain unclear. In this study, we have identified CagI, one of the T4SS proteins, which interacted with CagA and played an important role for CagA stability.
authors.affiliation: School of Medicine, Jiangsu University, 301 Xuefu Road, Zhenjiang, Jiangsu 212013, PR China.
authors.forename: Hua
authors.initials: H
authors.lastname: Wang
authors.affiliation: School of Medicine, Jiangsu University, 301 Xuefu Road, Zhenjiang, Jiangsu 212013, PR China.
authors.forename: Yizheng
authors.initials: Y
authors.lastname: Yao
authors.affiliation: School of Medicine, Jiangsu University, 301 Xuefu Road, Zhenjiang, Jiangsu 212013, PR China.
authors.forename: Bin
authors.initials: B
authors.lastname: Ni
authors.affiliation: School of Medicine, Jiangsu University, 301 Xuefu Road, Zhenjiang, Jiangsu 212013, PR China.
authors.forename: Yixin
authors.initials: Y
authors.lastname: Shen
authors.affiliation: School of Medicine, Jiangsu University, 301 Xuefu Road, Zhenjiang, Jiangsu 212013, PR China.
authors.forename: Xiaochun
authors.initials: X
authors.lastname: Wang
authors.affiliation: School of Medicine, Jiangsu University, 301 Xuefu Road, Zhenjiang, Jiangsu 212013, PR China. Electronic address: shx1975@126.com.
authors.forename: Hongxing
authors.initials: H
authors.lastname: Shen
authors.affiliation: School of Medicine, Jiangsu University, 301 Xuefu Road, Zhenjiang, Jiangsu 212013, PR China. Electronic address: shaoshihe2006@163.com.
authors.forename: Shihe
authors.initials: S
authors.lastname: Shao
mesh_terms: D000942:Antigens, Bacterial / Q000378:metabolism*; D001426:Bacterial Proteins / Q000378:metabolism*; D016480:Helicobacter pylori / Q000235:genetics / Q000378:metabolism*; D000069319:Type IV Secretion Systems / Q000235:genetics / Q000378:metabolism*
chemical_list: D000942:Antigens, Bacterial; D001426:Bacterial Proteins; D000069319:Type IV Secretion Systems; C080866:cagA protein, Helicobacter pylori
keywords: CagI; Helicobacter pylori; Secretion system; Type Ⅳ