title: Unsaturated Oral Fat Load Test Improves Glycemia, Insulinemia and Oxidative Stress Status in Nondiabetic Subjects with Abdominal Obesity.
abstract: OBJECTIVE
  To evaluate the changes in glycemia, insulinemia, and oxidative stress markers during an oral fat load test in nondiabetic subjects with abdominal obesity and to analyze the association between postprandial oxidative stress markers and postprandial glucose and insulin responses.
  
  
  METHODS
  We included 20 subjects with abdominal obesity (waist circumference > 102 cm for men and > 88 cm for women) and 20 healthy lean controls (waist circumference < 102 cm for men and < 88 cm for women). After 12 hours of fasting we performed a standardized fat load test (0-8 hours) with supracal® (50 g/m2). We determined metabolic parameters, oxidized and reduced glutathione, and malondialdehyde.
  
  
  RESULTS
  In both groups, insulin, HOMA, oxidized/reduced glutathione ratio, and malondialdehyde significantly decreased in the postprandial state after the OFLT. All these parameters were significantly higher in the abdominal obesity group at baseline and during all the postprandial points, but the reduction from the baseline levels was significantly higher in the abdominal obesity group.
  
  
  CONCLUSIONS
  Unsaturated fat improves insulin resistance and oxidative stress status. It is possible that a consumption of unsaturated fat could be beneficial even in subjects with abdominal obesity in postprandial state.
authors.affiliation: Service of Endocrinology and Nutrition, Hospital Clínico Universitario Valencia, Valencia, Spain.|Department of Medicine, University of Valencia, Valencia, Spain.|CIBER of Diabetes and Associated Metabolic Diseases (CIBERDEM), ISCIII, Madrid, Spain.
authors.forename: Sergio
authors.initials: S
authors.lastname: Martinez-Hervas
authors.affiliation: Service of Endocrinology and Nutrition, Hospital Clínico Universitario Valencia, Valencia, Spain.
authors.forename: Inmaculada
authors.initials: I
authors.lastname: Navarro
authors.affiliation: Service of Endocrinology and Nutrition, Hospital Clínico Universitario Valencia, Valencia, Spain.|Department of Medicine, University of Valencia, Valencia, Spain.|CIBER of Diabetes and Associated Metabolic Diseases (CIBERDEM), ISCIII, Madrid, Spain.
authors.forename: Jose T
authors.initials: JT
authors.lastname: Real
authors.affiliation: Service of Endocrinology and Nutrition, Hospital Clínico Universitario Valencia, Valencia, Spain.
authors.forename: Ana
authors.initials: A
authors.lastname: Artero
authors.affiliation: CIBER of Diabetes and Associated Metabolic Diseases (CIBERDEM), ISCIII, Madrid, Spain.|Hospital Clínico Research Foundation (INCLIVA), Valencia, Spain.
authors.forename: Marta
authors.initials: M
authors.lastname: Peiro
authors.affiliation: CIBER of Diabetes and Associated Metabolic Diseases (CIBERDEM), ISCIII, Madrid, Spain.|Hospital Clínico Research Foundation (INCLIVA), Valencia, Spain.
authors.forename: Herminia
authors.initials: H
authors.lastname: Gonzalez-Navarro
authors.affiliation: Department of Medicine, University of Valencia, Valencia, Spain.|CIBER of Diabetes and Associated Metabolic Diseases (CIBERDEM), ISCIII, Madrid, Spain.|Hospital Clínico Research Foundation (INCLIVA), Valencia, Spain.
authors.forename: Rafael
authors.initials: R
authors.lastname: Carmena
authors.affiliation: Service of Endocrinology and Nutrition, Hospital Clínico Universitario Valencia, Valencia, Spain.|Department of Medicine, University of Valencia, Valencia, Spain.|CIBER of Diabetes and Associated Metabolic Diseases (CIBERDEM), ISCIII, Madrid, Spain.
authors.forename: Juan F
authors.initials: JF
authors.lastname: Ascaso
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001786:Blood Glucose / Q000187:drug effects*; D016022:Case-Control Studies; D005224:Fats, Unsaturated / Q000494:pharmacology*; D005260:Female; D005978:Glutathione / Q000097:blood / Q000378:metabolism; D006801:Humans; D007328:Insulin / Q000097:blood*; D007333:Insulin Resistance; D008297:Male; D008315:Malondialdehyde / Q000097:blood / Q000378:metabolism; D008875:Middle Aged; D056128:Obesity, Abdominal; D018384:Oxidative Stress / Q000187:drug effects*; D019518:Postprandial Period / Q000187:drug effects*; D055815:Young Adult
chemical_list: D001786:Blood Glucose; D005224:Fats, Unsaturated; D007328:Insulin; D008315:Malondialdehyde; D005978:Glutathione