title: Role of local ablative techniques (Radiofrequency ablation and Irreversible Electroporation) in the treatment of pancreatic cancer.
abstract: Thanks to continuous research and investment in technology, the ablation of tumors has become common. Through the application of different types of energy is possible to induce cellular injury of the neoplastic tissue, leading to cellular death. Radiofrequency ablation (RFA) and irreversible electroporation (IRE) represent the most applied ablative techniques on pancreatic cancer. RFA and IRE, causing necrosis and apoptosis of neoplastic cells, are able to destroy neoplastic tissue, to drastically modify the neoplastic microenvironment and, possibly, to stimulate both directly and indirectly the anti-tumor immune system. This article provides part of our experience with the application of RFA and IRE on pancreatic adenocarcinoma (PDAC).
authors.affiliation: General and Pancreatic Surgery Department, The Pancreas Institute, University of Verona Hospital Trust, Piazzale L.A. Scuro 10, 37134, Verona, Italy.
authors.forename: Salvatore
authors.initials: S
authors.lastname: Paiella
authors.affiliation: General and Pancreatic Surgery Department, The Pancreas Institute, University of Verona Hospital Trust, Piazzale L.A. Scuro 10, 37134, Verona, Italy.
authors.forename: Roberto
authors.initials: R
authors.lastname: Salvia
authors.affiliation: Pancreatic Surgical Unit, Casa di Cura Pederzoli, Peschiera Del Garda, Verona, Italy.
authors.forename: Roberto
authors.initials: R
authors.lastname: Girelli
authors.affiliation: Pancreatic Surgical Unit, Casa di Cura Pederzoli, Peschiera Del Garda, Verona, Italy.
authors.forename: Isabella
authors.initials: I
authors.lastname: Frigerio
authors.affiliation: Pancreatic Surgical Unit, Casa di Cura Pederzoli, Peschiera Del Garda, Verona, Italy.
authors.forename: Alessandro
authors.initials: A
authors.lastname: Giardino
authors.affiliation: Radiology Department, The Pancreas Institute, University of Verona Hospital Trust, Verona, Italy.
authors.forename: Mirko
authors.initials: M
authors.lastname: D'Onofrio
authors.affiliation: Gastroenterology B Department, The Pancreas Institute, University of Verona Hospital Trust, Verona, Italy.
authors.forename: Giulia
authors.initials: G
authors.lastname: De Marchi
authors.affiliation: General and Pancreatic Surgery Department, The Pancreas Institute, University of Verona Hospital Trust, Piazzale L.A. Scuro 10, 37134, Verona, Italy. Claudio.bassi@univr.it.
authors.forename: Claudio
authors.initials: C
authors.lastname: Bassi
mesh_terms: D000230:Adenocarcinoma / Q000601:surgery*; D017115:Catheter Ablation / Q000379:methods*; D018274:Electroporation / Q000379:methods*; D006801:Humans; D010180:Pancreatectomy / Q000379:methods*; D010190:Pancreatic Neoplasms / Q000601:surgery*; D016896:Treatment Outcome
keywords: Ablative techniques; Irreversible electroporation; Locally advanced pancreatic adenocarcinoma; Pancreatic carcinoma; Radiofrequency ablation