title: Insights on the Auxochromic Properties of the Guanidinium Group.
abstract: UV/vis spectra of phenylguanidine (PHGU) in the gas phase and in acetonitrile have been simulated by TD-DFT calculations. Several DFT hybrid and long-range corrected functionals were tested with respect to CASPT2 gas phase calculations. Solvent effects were considered using polarizable continuum model (PCM) and compared with the measured data in acetonitrile. Comparison with isoelectronic phenylurea and related phenyltiourea was done as well. The PBE0 and long-range corrected CAM-B3LYP functionals were selected to investigate the effect of protonation on the excitation energies and absorption intensities of PHGU and several guanidine derivatives with different aromatic chromophoric groups (naphthyl, anthracenyl, quinolinyl, anthraquinonyl, and coumarinyl). Also, the effect of complexation and specific interactions through hydrogen bonds with different anions was examined. It was shown that the protonation of the guanidine subunit shifts the low energy absorption bands toward higher energies (hypsochromic shift). The shift is reduced upon complexation with anions. In phenylguanidine salts, λmax values are correlated to the anion basicity and strength of H-bonding. The observed changes diminish upon increase of chromophoric size (naphthyl, anthracenyl). Theoretical predictions of UV/vis spectra correlate well with experimentally measured spectra of selected guanidine derivatives and their salts.
authors.affiliation: Division of Organic Chemistry and Biochemistry, Ruđer Bošković Institute , P.O.B. 180, HR-10002 Zagreb, Croatia.
authors.forename: Ivana
authors.initials: I
authors.lastname: Antol
authors.affiliation: Division of Organic Chemistry and Biochemistry, Ruđer Bošković Institute , P.O.B. 180, HR-10002 Zagreb, Croatia.
authors.forename: Zoran
authors.initials: Z
authors.lastname: Glasovac
authors.affiliation: Division of Organic Chemistry and Biochemistry, Ruđer Bošković Institute , P.O.B. 180, HR-10002 Zagreb, Croatia.
authors.forename: Davor
authors.initials: D
authors.lastname: Margetić
authors.affiliation: School of Biological and Chemical Sciences, Materials Research Institute, Queen Mary University of London , Mile End Road, London E1 4NS, U.K.
authors.forename: Rachel
authors.initials: R
authors.lastname: Crespo-Otero
authors.affiliation: Aix Marseille Université , CNRS, ICR, 13284 Marseille, France.
authors.forename: Mario
authors.initials: M
authors.lastname: Barbatti
mesh_terms: D000097:Acetonitriles / Q000737:chemistry; D000873:Anthracenes / Q000737:chemistry; D000880:Anthraquinones / Q000737:chemistry; D019791:Guanidine / Q000737:chemistry*; D006146:Guanidines / Q000737:chemistry; D006860:Hydrogen Bonding; D008956:Models, Chemical; D009281:Naphthalenes / Q000737:chemistry; D011804:Quinolines / Q000737:chemistry; D012997:Solvents / Q000737:chemistry; D013056:Spectrophotometry, Ultraviolet / Q000379:methods*
chemical_list: D000097:Acetonitriles; D000873:Anthracenes; D000880:Anthraquinones; D006146:Guanidines; D009281:Naphthalenes; D011804:Quinolines; D012997:Solvents; C026943:phenylguanidine; C031721:naphthalene; C037219:quinoline; C034020:anthracene; D019791:Guanidine; C032159:acetonitrile