title: Disseminated intravascular coagulation in paediatrics.
abstract: Disseminated intravascular coagulation (DIC) in paediatrics is associated with significant morbidity and mortality. Although there have been several recent advances in the pathophysiology of DIC, most of these studies were done in adults. Since the haemostatic system is very different in early life and changes dramatically with age, creating a variety of challenges for the clinician, delay in the diagnosis of DIC can happen until overt DIC is evident. In this review article, we report the aetiology, pathophysiology, clinical manifestations, diagnostic tests and a management algorithm to guide paediatricians when treating patients with DIC.
authors.affiliation: Paediatric Haemato-Oncology, Department of Paediatrics, University of Malaya, Kuala Lumpur, Malaysia.
authors.forename: Revathi
authors.initials: R
authors.lastname: Rajagopal
authors.affiliation: Department of Haematology, Manchester Royal Infirmary, Manchester, UK.
authors.forename: Jecko
authors.initials: J
authors.lastname: Thachil
authors.affiliation: Department of Clinical Haematology, Royal Children's Hospital Melbourne, Melbourne, Australia.|Department of Paediatrics, University of Melbourne, Melbourne, Australia.|Haematology Research, Murdoch Children Research Institute, Melbourne, Australia.
authors.forename: Paul
authors.initials: P
authors.lastname: Monagle
mesh_terms: D000293:Adolescent; D000925:Anticoagulants / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D004211:Disseminated Intravascular Coagulation / Q000175:diagnosis / Q000209:etiology / Q000628:therapy*; D006487:Hemostasis / Q000502:physiology; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D018805:Sepsis / Q000175:diagnosis / Q000628:therapy
chemical_list: D000925:Anticoagulants
keywords: Diagnosis; Disseminated intravascular coagulation; Management; Paediatrics