title: Anti-acne, anti-dandruff and anti-breast cancer efficacy of green synthesised silver nanoparticles using Coriandrum sativum leaf extract.
abstract: In this present investigation, AgNPs were green synthesised using Coriandrum sativum leaf extract. The physicochemical properties of AgNPs were characterised using UV-visible spectrophotometer, field emission scanning microscopy/energy dispersive X-ray (FESEM/EDX), Fourier transformed infrared spectroscopy (FT-IR), X-ray diffraction (XRD) and Brunauer-Emmett-Teller (BET) analysis. Further, in vitro anti-acne, anti-dandruff and anti-breast cancer efficacy of green synthesised AgNPs were assessed against Propionibacterium acnes MTCC 1951, Malassezia furfur MTCC 1374 and human breast adenocarcinoma (MCF-7) cell line, respectively. The flavonoids present in the plant extract were responsible for the AgNPs synthesis. The green synthesised nanoparticles size was found to be ≈37nm. The BET analysis result shows that the surface area of the synthesised AgNPs was found to be 33.72m(2)g(-1). The minimal inhibitory concentration (MIC) of AgNPs for acne causative agent P. acnes and dandruff causative agent M. furfur was found to be at 3.1 and 25μgmL(-1), respectively. The half maximal inhibitory concentration (IC50) value of the AgNPs for MCF-7 cells was calculated as 30.5μgmL(-1) and complete inhibition was observed at a concentration of 100μgmL(-1). Finally, our results proved that green synthesised AgNPs using C. sativum have great potential in biomedical applications such as anti-acne, anti-dandruff and anti-breast cancer treatment.
authors.affiliation: Centre for Environmental Sustainability and Water Security (IPASA), Research Institute for Sustainable Environment (RISE), Universiti Teknologi Malaysia, 81310, Skudai, Johor Bahru, Malaysia.
authors.forename: Palanivel
authors.initials: P
authors.lastname: Sathishkumar
authors.affiliation: Laboratory of Bioprocess and Engineering, Department of Biochemistry, Periyar University, Salem 636 011, Tamil Nadu, India.
authors.forename: Johnson
authors.initials: J
authors.lastname: Preethi
authors.affiliation: Laboratory of Bioprocess and Engineering, Department of Biochemistry, Periyar University, Salem 636 011, Tamil Nadu, India.
authors.forename: Raji
authors.initials: R
authors.lastname: Vijayan
authors.affiliation: Centre for Environmental Sustainability and Water Security (IPASA), Research Institute for Sustainable Environment (RISE), Universiti Teknologi Malaysia, 81310, Skudai, Johor Bahru, Malaysia; Centre for Sustainable Nanomaterials, Ibnu Sina Institute for Scientific and Industrial Research (ISI-SIR), Universiti Teknologi Malaysia, 81310 Skudai, Johor Bahru, Malaysia. Electronic address: rahim@bfs.utm.my.
authors.forename: Abdull Rahim
authors.initials: AR
authors.lastname: Mohd Yusoff
authors.affiliation: Department of Botany and Microbiology, Faculty of Science, King Saud University, Riyadh, Saudi Arabia.
authors.forename: Fuad
authors.initials: F
authors.lastname: Ameen
authors.affiliation: Research and Development Center, Bharathiar University, Coimbatore 641 046, Tamil Nadu, India.
authors.forename: Sadhasivam
authors.initials: S
authors.lastname: Suresh
authors.affiliation: Actinobacterial Research Laboratory, Department of Microbiology, Periyar University, Salem 636 011, Tamil Nadu, India.
authors.forename: Ramasamy
authors.initials: R
authors.lastname: Balagurunathan
authors.affiliation: Laboratory of Bioprocess and Engineering, Department of Biochemistry, Periyar University, Salem 636 011, Tamil Nadu, India. Electronic address: pal2912@yahoo.com.
authors.forename: Thayumanavan
authors.initials: T
authors.lastname: Palvannan
mesh_terms: D000152:Acne Vulgaris / Q000188:drug therapy* / Q000382:microbiology; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D001943:Breast Neoplasms / Q000473:pathology*; D060326:Chemistry Techniques, Synthetic; D028526:Coriandrum / Q000737:chemistry*; D063807:Dandruff / Q000188:drug therapy* / Q000382:microbiology; D055772:Green Chemistry Technology; D006801:Humans; D061986:MCF-7 Cells; D008290:Malassezia / Q000187:drug effects; D053768:Metal Nanoparticles / Q000737:chemistry*; D008826:Microbial Sensitivity Tests; D064209:Phytochemicals / Q000737:chemistry; D018515:Plant Leaves / Q000737:chemistry*; D011425:Propionibacterium acnes / Q000187:drug effects; D012834:Silver / Q000737:chemistry*
chemical_list: D000900:Anti-Bacterial Agents; D000970:Antineoplastic Agents; D064209:Phytochemicals; D012834:Silver
keywords: Coriandrum sativum; Flavonoids; Human breast adenocarcinoma cell line; Malassezia furfur; Propionibacterium acnes; Silver nanoparticles