title: Tomato receptor FLAGELLIN-SENSING 3 binds flgII-28 and activates the plant immune system.
abstract: Plants and animals detect the presence of potential pathogens through the perception of conserved microbial patterns by cell surface receptors. Certain solanaceous plants, including tomato, potato and pepper, detect flgII-28, a region of bacterial flagellin that is distinct from that perceived by the well-characterized FLAGELLIN-SENSING 2 receptor. Here we identify and characterize the receptor responsible for this recognition in tomato, called FLAGELLIN-SENSING 3. This receptor binds flgII-28 and enhances immune responses leading to a reduction in bacterial colonization of leaf tissues. Further characterization of FLS3 and its signalling pathway could provide new insights into the plant immune system and transfer of the receptor to other crop plants offers the potential of enhancing resistance to bacterial pathogens that have evolved to evade FLS2-mediated immunity.
authors.affiliation: Boyce Thompson Institute for Plant Research, Ithaca, New York 14853, USA.
authors.forename: Sarah R
authors.identifier: 0000-0003-3090-0061
authors.initials: SR
authors.lastname: Hind
authors.affiliation: Boyce Thompson Institute for Plant Research, Ithaca, New York 14853, USA.
authors.forename: Susan R
authors.initials: SR
authors.lastname: Strickler
authors.affiliation: Boyce Thompson Institute for Plant Research, Ithaca, New York 14853, USA.
authors.forename: Patrick C
authors.initials: PC
authors.lastname: Boyle
authors.affiliation: Boyce Thompson Institute for Plant Research, Ithaca, New York 14853, USA.
authors.forename: Diane M
authors.initials: DM
authors.lastname: Dunham
authors.affiliation: Boyce Thompson Institute for Plant Research, Ithaca, New York 14853, USA.
authors.forename: Zhilong
authors.initials: Z
authors.lastname: Bao
authors.affiliation: Boyce Thompson Institute for Plant Research, Ithaca, New York 14853, USA.|Department of Chemistry and Chemical Biology, Cornell University, Ithaca, New York 14853, USA.
authors.forename: Inish M
authors.initials: IM
authors.lastname: O'Doherty
authors.affiliation: Boyce Thompson Institute for Plant Research, Ithaca, New York 14853, USA.|Department of Chemistry and Chemical Biology, Cornell University, Ithaca, New York 14853, USA.
authors.forename: Joshua A
authors.identifier: 0000-0003-4334-755X
authors.initials: JA
authors.lastname: Baccile
authors.affiliation: Boyce Thompson Institute for Plant Research, Ithaca, New York 14853, USA.|Department of Chemistry and Chemical Biology, Cornell University, Ithaca, New York 14853, USA.
authors.forename: Jason S
authors.initials: JS
authors.lastname: Hoki
authors.affiliation: Boyce Thompson Institute for Plant Research, Ithaca, New York 14853, USA.
authors.forename: Elise G
authors.initials: EG
authors.lastname: Viox
authors.affiliation: Department of Plant Pathology, Physiology and Weed Sciences, Virginia Tech, Blacksburg, Virginia 24061, USA.
authors.forename: Christopher R
authors.initials: CR
authors.lastname: Clarke
authors.affiliation: Department of Plant Pathology, Physiology and Weed Sciences, Virginia Tech, Blacksburg, Virginia 24061, USA.
authors.forename: Boris A
authors.initials: BA
authors.lastname: Vinatzer
authors.affiliation: Boyce Thompson Institute for Plant Research, Ithaca, New York 14853, USA.|Department of Chemistry and Chemical Biology, Cornell University, Ithaca, New York 14853, USA.
authors.forename: Frank C
authors.initials: FC
authors.lastname: Schroeder
authors.affiliation: Boyce Thompson Institute for Plant Research, Ithaca, New York 14853, USA.|Section of Plant Pathology and Plant-Microbe Biology, School of Integrative Plant Science, Cornell University, Ithaca, New York 14853, USA.
authors.forename: Gregory B
authors.identifier: 0000-0003-0044-6830
authors.initials: GB
authors.lastname: Martin
mesh_terms: D005408:Flagellin / Q000378:metabolism*; D018551:Solanum lycopersicum / Q000235:genetics* / Q000276:immunology* / Q000382:microbiology; D057865:Plant Immunity; D018515:Plant Leaves / Q000276:immunology / Q000382:microbiology; D010940:Plant Proteins / Q000235:genetics* / Q000378:metabolism; D011494:Protein Kinases / Q000235:genetics* / Q000378:metabolism; D015398:Signal Transduction
chemical_list: D010940:Plant Proteins; D005408:Flagellin; D011494:Protein Kinases