title: Focal Cortical Dysplasia in Childhood Epilepsy.
abstract: Focal cortical dysplasia is a common cause of medication resistant epilepsy. A better understanding of its presentation, pathophysiology and consequences have helped us improved its treatment and outcome. This paper reviews the most recent classification, pathophysiology and imaging findings in clinical research as well as the knowledge gained from studying genetic and lesional animal models of focal cortical dysplasia. This review of this recently gained knowledge will most likely help develop new research models and new therapeutic targets for patients with epilepsy associated with focal cortical dysplasia.
authors.affiliation: Division of Neurology, Department of Pediatrics and Neurosciences, CHU Sainte-Justine, University of Montreal, Montreal, Quebec, Canada.
authors.forename: Tarek
authors.initials: T
authors.lastname: Shaker
authors.affiliation: Division of Neurology, Department of Pediatrics and Neurosciences, CHU Sainte-Justine, University of Montreal, Montreal, Quebec, Canada.
authors.forename: Anne
authors.initials: A
authors.lastname: Bernier
authors.affiliation: Division of Neurology, Department of Pediatrics and Neurosciences, CHU Sainte-Justine, University of Montreal, Montreal, Quebec, Canada. Electronic address: lionel.carmant@umontreal.ca.
authors.forename: Lionel
authors.initials: L
authors.lastname: Carmant
mesh_terms: D000818:Animals; D002648:Child; D004195:Disease Models, Animal; D004827:Epilepsy / Q000209:etiology; D006801:Humans; D054220:Malformations of Cortical Development / Q000150:complications