title: Reversal of profound neuromuscular blockade with sugammadex in an infant after bronchial foreign body removal.
abstract: Sugammadex is a selective chemical agent that can reverse neuromuscular blockade induced by vecuronium and rocuronium. The aim of this report is to discuss the effectiveness of sugammadex in the reversal of neuromuscular blockade in children younger than 2 years. A 16-month-old boy, weighing 10 kg, was admitted to the pediatric emergency department due to choking, cyanosis, and severe respiratory distress that occurred while he was eating peanuts. In the emergency department, the patient's condition deteriorated, and he went into respiratory arrest. He was immediately intubated and taken to the operating room. A rigid bronchoscopy was performed under general anesthesia, with administration of intravenous pentothal (5 mg/kg), rocuronium (0.6 mg/kg), and fentanyl (0.5 μg/kg) in the operating room. The foreign body was removed within 6 minutes, and the profound neuromuscular blockade was reversed with a dose of 2 mg/kg sugammadex. He was extubated successfully after obtaining the spontaneous respiratory activity, and adequate breathing was restored. Clinical use of sugammadex in children younger than 2 years is not recommended because of the lack of clinical studies. In this case report, the profound neuromuscular blockade was successfully reversed with a dose of 2 mg/kg sugammadex in a 16-month-old boy. However, more prospective clinical studies are required for the safe use of this agent in children.
authors.affiliation: Department of Anesthesiology and Reanimation, Faculty of Medicine, University of Mersin, Mersin, Turkey. Electronic address: dryalamaoglu@hotmail.com.
authors.forename: Mustafa
authors.initials: M
authors.lastname: Azizoglu
authors.affiliation: Department of Anesthesiology and Reanimation, Faculty of Medicine, University of Mersin, Mersin, Turkey.
authors.forename: Handan
authors.initials: H
authors.lastname: Birbicer
authors.affiliation: Department of Anesthesiology and Reanimation, Faculty of Medicine, University of Mersin, Mersin, Turkey.
authors.forename: Suleyman
authors.initials: S
authors.lastname: Memis
authors.affiliation: Department of Pediatric Surgery, Faculty of Medicine, University of Mersin, Mersin, Turkey.
authors.forename: Hakan
authors.initials: H
authors.lastname: Taşkınlar
mesh_terms: D010367:Arachis; D001980:Bronchi / Q000601:surgery*; D001999:Bronchoscopy; D005547:Foreign Bodies / Q000601:surgery*; D006801:Humans; D007223:Infant; D008297:Male; D019148:Neuromuscular Blockade / Q000379:methods*; D000077122:Sugammadex; D016896:Treatment Outcome; D047408:gamma-Cyclodextrins
chemical_list: D047408:gamma-Cyclodextrins; D000077122:Sugammadex
keywords: General anesthesia; Infant; Neuromuscular blocking drugs; Sugammadex