title: Study about the Efficacy of Metformin to Immune Function in Cancer Patients.
abstract: A study to evaluate the effect of metformin on the immune system was commenced in July 2014. Metformin is one of the most commonly prescribed drugs for type 2 diabetes, and previous studies have reported that metformin has an anti-tumor effect. The aim of this study is to evaluate the efficacy of metformin on the immune system in human cancer patients in vivo. The primary outcome parameter will be the rate change in the population of CD8＋ T cells, which produce multiple cytokines.
authors.affiliation: Department of Thoracic, Breast and Endocrinological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700-8558, Japan.
authors.forename: Mototsugu
authors.initials: M
authors.lastname: Watanabe
authors.forename: Hiromasa
authors.initials: H
authors.lastname: Yamamoto
authors.forename: Shingo
authors.initials: S
authors.lastname: Eikawa
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Shien
authors.forename: Tadahiko
authors.initials: T
authors.lastname: Shien
authors.forename: Junichi
authors.initials: J
authors.lastname: Soh
authors.forename: Katsuyuki
authors.initials: K
authors.lastname: Hotta
authors.forename: Jun
authors.initials: J
authors.lastname: Wada
authors.forename: Shiro
authors.initials: S
authors.lastname: Hinotsu
authors.forename: Toshiyoshi
authors.initials: T
authors.lastname: Fujiwara
authors.forename: Katsuyuki
authors.initials: K
authors.lastname: Kiura
authors.forename: Hiroyoshi
authors.initials: H
authors.lastname: Doihara
authors.forename: Shinichiro
authors.initials: S
authors.lastname: Miyoshi
authors.forename: Heiichiro
authors.initials: H
authors.lastname: Udono
authors.forename: Shinichi
authors.initials: S
authors.lastname: Toyooka
mesh_terms: D018414:CD8-Positive T-Lymphocytes / Q000502:physiology*; D002985:Clinical Protocols; D016207:Cytokines / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D007004:Hypoglycemic Agents / Q000494:pharmacology; D008687:Metformin / Q000494:pharmacology*; D009369:Neoplasms / Q000276:immunology*
chemical_list: D016207:Cytokines; D007004:Hypoglycemic Agents; D008687:Metformin