title: Transcutaneous Oximetry May Predict Wound Healing Complications In Preoperatively Radiated Soft Tissue Sarcoma.
abstract: Preoperative radiation is frequently used in management of soft tissue sarcoma. We hypothesize that anoxic tissue from preoperative radiation contributes to surgical wound complications and that transcutaneous oximetry (TcO2) measurements made preoperatively can predict wounds at risk.
  
  
  
  Ten consecutive patients were prospectively enrolled. TcO2 was recorded at five time points. Wound complications (defined as major or minor) and healing outcomes were recorded out to 120 days postoperatively. Means between groups with and without wound complications were compared by use of a Student's t-test (p < 0.05).
  
  
  
  There were three major and one minor wound complication. During the time from radiation to surgery, patients with wound complications had a 13.1 mmHg decrease in mean TcO2 while those who healed uneventfully had an increase of 2.3 mm Hg (p=0.09). Patients with complications had a low preoperative TcO2 of 18.7 mmHg compared to those without complications (18.7 vs. 33.4 mmHg; p=0.09). No patient with a TcO2 greater than 25 mmHg immediately preoperatively developed a wound complication.
  
  
  
  This data suggests an earlier recovery of tissue oxygenation in patients that healed without complication. The TcO2 measurement immediately preceding surgery seems to be the most important in predicting wound complications. Larger scale investigation may determine if TcO2 measurement is a viable clinical tool to aid in risk assessment for potential wound complications.
authors.forename: Lukas M
authors.initials: LM
authors.lastname: Nystrom
authors.forename: Benjamin J
authors.initials: BJ
authors.lastname: Miller
mesh_terms: D000328:Adult; D000368:Aged; D001785:Blood Gas Monitoring, Transcutaneous; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D020360:Neoadjuvant Therapy / Q000009:adverse effects*; D010865:Pilot Projects; D011183:Postoperative Complications / Q000175:diagnosis*; D011300:Preoperative Care; D018714:Radiotherapy, Adjuvant / Q000009:adverse effects; D012509:Sarcoma / Q000532:radiotherapy / Q000601:surgery*; D012983:Soft Tissue Neoplasms / Q000532:radiotherapy / Q000601:surgery*; D013524:Surgical Flaps; D014945:Wound Healing / Q000502:physiology; D055815:Young Adult