title: miR-181b-5p, miR-195-5p and miR-301a-3p are related with treatment resistance in schizophrenia.
abstract: The aim of the study was to determine the differences between expression levels of certain miRNAs, as their association with schizophrenia has been well presented in the literature, and to investigate their relation to treatment resistance in schizophrenic patients. Three groups were formed: 1) treatment-resistant group, 2) treatment responsive group and 3) healthy control group. Expression levels of miRNAs from peripheric blood samples were determined by real-time quantitative reverse transcription polymerase chain reaction (qRT-PCR). We investigated the roles of 29 schizophrenia-related miRNAs in schizophrenia treatment and their potentials to be considered as indicators. Among these miRNAs, only miR-181b-5p, miR-195-5p and miR-301a-3p expressions were found to be significantly different between the treatment-resistant group and the group responding well to the treatment. miRNAs may cause resistance by silencing the receptor genes of the drugs used for schizophrenia treatment. miR-181b-5p, miR-195-5p and miR-301a-3p may be candidate indicators that can be used to reveal resistance against schizophrenia treatment.
authors.affiliation: Department of Psychiatry, Faculty of Medicine, Pamukkale University, Denizli, Turkey. Electronic address: dr.huseyinalacam@hotmail.com.
authors.forename: Huseyin
authors.initials: H
authors.lastname: Alacam
authors.affiliation: Department of Medical Biology, Faculty of Medicine, Pamukkale University, Denizli, Turkey.
authors.forename: Sakir
authors.initials: S
authors.lastname: Akgun
authors.affiliation: Department of Medical Biology, Faculty of Medicine, Pamukkale University, Denizli, Turkey.
authors.forename: Hakan
authors.initials: H
authors.lastname: Akca
authors.affiliation: Department of Child and Adolescent Psychiatry, Faculty of Medicine, Pamukkale University, Denizli, Turkey.
authors.forename: Onder
authors.initials: O
authors.lastname: Ozturk
authors.affiliation: Department of Child and Adolescent Psychiatry, Faculty of Medicine, Pamukkale University, Denizli, Turkey.
authors.forename: Burge Basay
authors.initials: BB
authors.lastname: Kabukcu
authors.affiliation: Department of Psychiatry, Faculty of Medicine, Pamukkale University, Denizli, Turkey.
authors.forename: Hasan
authors.initials: H
authors.lastname: Herken
mesh_terms: D000328:Adult; D014150:Antipsychotic Agents / Q000627:therapeutic use*; D016022:Case-Control Studies; D004351:Drug Resistance / Q000235:genetics; D005260:Female; D020869:Gene Expression Profiling; D020868:Gene Silencing; D006801:Humans; D008297:Male; D035683:MicroRNAs / Q000235:genetics*; D008875:Middle Aged; D060888:Real-Time Polymerase Chain Reaction; D012559:Schizophrenia / Q000188:drug therapy* / Q000235:genetics*
chemical_list: D014150:Antipsychotic Agents; D035683:MicroRNAs
keywords: MiR-181b-5p; MiR-195-5p; MiR301a-3p; Schizophrenia; Treatment-resistant schizophrenia