title: Topical imiquimod in the treatment of extramammary Paget's disease: A 10 year retrospective analysis in an Asian tertiary centre.
abstract: Extramammary Paget's disease (EMPD) is a rare intraepithelial adenocarcinoma usually found in apocrine-rich areas. Although surgery remains standard treatment, topical imiquimod has emerged as a promising drug for the treatment of EMPD in recent years. We present our experience in treating EMPD in Asian skin successfully with topical imiquimod 5% cream, over the past 10 years in our tertiary institution.
authors.affiliation: University Dermatology Clinic, National University Health System, Republic of Singapore.
authors.forename: MeiQi May
authors.initials: MM
authors.lastname: Liau
authors.affiliation: University Dermatology Clinic, National University Health System, Republic of Singapore.
authors.forename: Shiyao Sam
authors.initials: SS
authors.lastname: Yang
authors.affiliation: Pathology Department, National University Health System, Republic of Singapore.
authors.forename: Kong Bing
authors.initials: KB
authors.lastname: Tan
authors.affiliation: University Dermatology Clinic, National University Health System, Republic of Singapore.
authors.forename: Chen Wee Derrick
authors.initials: CW
authors.lastname: Aw
mesh_terms: D000279:Administration, Cutaneous; D000368:Aged; D000369:Aged, 80 and over; D000634:Aminoquinolines / Q000008:administration & dosage* / Q000009:adverse effects; D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000009:adverse effects; D001706:Biopsy; D005260:Female; D006801:Humans; D000077271:Imiquimod; D008297:Male; D010145:Paget Disease, Extramammary / Q000175:diagnosis / Q000188:drug therapy*; D010412:Penile Neoplasms / Q000175:diagnosis / Q000188:drug therapy*; D012189:Retrospective Studies; D012846:Singapore; D063465:Skin Cream; D013544:Sweat Gland Neoplasms / Q000175:diagnosis / Q000188:drug therapy*; D062606:Tertiary Care Centers; D013997:Time Factors; D016896:Treatment Outcome; D014846:Vulvar Neoplasms / Q000175:diagnosis / Q000188:drug therapy*
chemical_list: D000634:Aminoquinolines; D000970:Antineoplastic Agents; D000077271:Imiquimod
keywords: Asian skin; extramammary Paget's disease (EMPD); topical imiquimod