title: Near-infrared luminescence and RNA cleavage ability of lanthanide Schiff base complexes derived from N,N'-bis(3-methoxysalicylidene)ethylene-1,2-diamine ligands.
abstract: A complete series of lanthanide Schiff base salen-type complexes were prepared with trivalent lanthanide ions (Ln3+) and the N,N'-bis-(3-methoxysalicylidene)ethylene-1,2-diamine ligand (Ln3+=La3+, Ce3+, Pr3+, Nd3+, Sm3+, Eu3+, Gd3+, Tb3+, Dy3+, Ho3+, Er3+, Tm3+, Yb3+, Lu3+). Three unique crystal structures of La3+and Pr3+N,N'-bis-(3-methoxysalicylidene)ethylene-1,2-diamine complexes, with the La3+complex prepared in two different synthetic approaches, are reported, namely a dimeric [La(H2L)(NO3)3]2(H2L=N,N'-bis-(3-methoxysalicylidene)ethylene-1,2-diamine) complex, an asymmetric two-centered [La2(H2L)2(NO3)6] complex and a discrete mononuclear [Pr(H2L)(NO3)2(H2O)2] complex. For Nd3+and Sm3+, an isotypic mononuclear [Nd(H2L)(NO3)3] and 1D polymeric [Sm(H2L)(NO3)3(MeOH)]nstructure was obtained, respectively. The whole series of complexes was tested for their ability to cleave the 20-mer RNA oligonucleotide 5'-AGC-GAU-AAG-AUU-CAU-AUA-UC-3'. Additionally three complexes (Ln3+=Nd3+, Sm3+, Ho3+) were tested for the cleavage of the 12-mer RNA oligonucleotide 5'-GCA-CCC-UGU-CAG-3'. A detailed luminescence study was additionally carried out and revealed that the Eu3+complex emitted bright red light upon excitation at both 285.8nm and 394.4nm. The Nd3+, Er3+, and Yb3+complexes showed strong emission in the near-infrared region after excitation at 380nm.
authors.affiliation: L(3) - Luminescent Lanthanide Lab, Department of Inorganic and Physical Chemistry, Ghent University, Krijgslaan 281-S3, B-9000 Ghent, Belgium. Electronic address: Anna.Kaczmarek@UGent.be.
authors.forename: Anna M
authors.initials: AM
authors.lastname: Kaczmarek
authors.affiliation: Separation Science Group, Department of Organic and Macromolecular Chemistry, Ghent University, Krijgslaan 281-S4, B-9000 Ghent, Belgium.
authors.forename: Piotr W Alvarez
authors.initials: PW
authors.lastname: Porebski
authors.affiliation: XStruct, Department of Inorganic and Physical Chemistry, Ghent University, Krijgslaan 281-S3, B-9000 Ghent, Belgium.
authors.forename: Tineke
authors.initials: T
authors.lastname: Mortier
authors.affiliation: Separation Science Group, Department of Organic and Macromolecular Chemistry, Ghent University, Krijgslaan 281-S4, B-9000 Ghent, Belgium.
authors.forename: Frederic
authors.initials: F
authors.lastname: Lynen
authors.affiliation: L(3) - Luminescent Lanthanide Lab, Department of Inorganic and Physical Chemistry, Ghent University, Krijgslaan 281-S3, B-9000 Ghent, Belgium.
authors.forename: Rik
authors.initials: R
authors.lastname: Van Deun
authors.affiliation: XStruct, Department of Inorganic and Physical Chemistry, Ghent University, Krijgslaan 281-S3, B-9000 Ghent, Belgium. Electronic address: Kristof.VanHecke@UGent.be.
authors.forename: Kristof
authors.initials: K
authors.lastname: Van Hecke
mesh_terms: D003959:Diamines / Q000737:chemistry*; D028581:Lanthanoid Series Elements / Q000737:chemistry*; D008163:Luminescent Measurements; D009843:Oligoribonucleotides / Q000737:chemistry*; D012313:RNA / Q000737:chemistry*
chemical_list: D003959:Diamines; D028581:Lanthanoid Series Elements; D009843:Oligoribonucleotides; D012313:RNA
keywords: Crystal structure; Lanthanide; Luminescence; RNA cleavage; Schiff base