title: Myxofibrosarcoma of the heart: A case report with positive pleural effusion cytology.
abstract: Primary cardiac sarcoma is rare, and there have been only a few reports on its cytologic findings. Myxofibrosarcoma, a variant of fibrosarcoma of the heart, is an extremely rare entity. We present a case of primary cardiac myxofibrosarcoma in a 63-year-old woman. Pleural fluid cytology and imprint cytology of the resected tumor at operation and autopsy were obtained. Cytologic evaluation with immunocytochemical staining utilizing a cell transfer technique revealed that tumor cells of the resected tumor and autopsy specimen and pleural effusion demonstrated large and pleomorphic cells with irregular, hyperchromatic nuclei and were positive for vimentin. Combination of morphology and immunoprofile of the cells of pleural effusion was compatible with the diagnosis of metastatic myxofibrosarcoma. Diagn. Cytopathol. 2016;44:1112-1116. © 2016 Wiley Periodicals, Inc.
authors.affiliation: Department of Pathology, Tazuke Kofukai Foundation, Medical Research Institute, Kitano Hospital, Osaka, Japan.
authors.forename: Yoko
authors.initials: Y
authors.lastname: Hagiwara
authors.affiliation: Department of Pathology, Tazuke Kofukai Foundation, Medical Research Institute, Kitano Hospital, Osaka, Japan.
authors.forename: Kayoko
authors.initials: K
authors.lastname: Nakamura
authors.affiliation: Department of Pathology, Tazuke Kofukai Foundation, Medical Research Institute, Kitano Hospital, Osaka, Japan.
authors.forename: Masako
authors.initials: M
authors.lastname: Taguchi
authors.affiliation: Department of Pathology, Tazuke Kofukai Foundation, Medical Research Institute, Kitano Hospital, Osaka, Japan.
authors.forename: Ayaka
authors.initials: A
authors.lastname: Ashiwa
authors.affiliation: Department of Pathology, Tazuke Kofukai Foundation, Medical Research Institute, Kitano Hospital, Osaka, Japan.
authors.forename: Chieko
authors.initials: C
authors.lastname: Nishioka
authors.affiliation: Department of Pathology, Tazuke Kofukai Foundation, Medical Research Institute, Kitano Hospital, Osaka, Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Kono
authors.affiliation: Department of Pathology, Tazuke Kofukai Foundation, Medical Research Institute, Kitano Hospital, Osaka, Japan.
authors.forename: Naomi
authors.initials: N
authors.lastname: Matsuzaki
authors.affiliation: Department of Pathology, Tazuke Kofukai Foundation, Medical Research Institute, Kitano Hospital, Osaka, Japan.
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Yuba
mesh_terms: D003937:Diagnosis, Differential; D005260:Female; D005354:Fibrosarcoma / Q000473:pathology*; D006338:Heart Neoplasms / Q000473:pathology*; D006801:Humans; D008875:Middle Aged; D009232:Myxoma / Q000473:pathology*; D016066:Pleural Effusion, Malignant / Q000473:pathology*
keywords: cardiac sarcoma; immunocytochemistry; imprint cytology; myxofibrosarcoma; pleural effusion cytology