title: Computational simulation analysis on human SOD1 mutant (H80R) exposes the structural destabilization and the deviation of Zn binding that directs familial amyotrophic lateral sclerosis.
authors.affiliation: a Department of Biotechnology, School of Bio Sciences and Technology , VIT University , Vellore 632014 , Tamil Nadu , India.
authors.forename: E
authors.initials: E
authors.lastname: Srinivasan
authors.affiliation: a Department of Biotechnology, School of Bio Sciences and Technology , VIT University , Vellore 632014 , Tamil Nadu , India.
authors.forename: R
authors.initials: R
authors.lastname: Rajasekaran
mesh_terms: D000690:Amyotrophic Lateral Sclerosis / Q000201:enzymology* / Q000378:metabolism / Q000473:pathology; D001665:Binding Sites; D003198:Computer Simulation; D004795:Enzyme Stability / Q000235:genetics; D006801:Humans; D050505:Mutant Proteins / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism; D009154:Mutation; D011487:Protein Conformation; D000072105:Superoxide Dismutase-1 / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism; D015032:Zinc / Q000737:chemistry
chemical_list: D050505:Mutant Proteins; C000606290:SOD1 protein, human; D000072105:Superoxide Dismutase-1; D015032:Zinc