title: Microenvironment-Responsive Three-Pronged Approach Breaking Traditional Chemotherapy to Target Cancer Stem Cells for Synergistic Inoperable Large Tumor Therapy.
abstract: Three-pronged nanoparticles (NPs) that can efficiently prohibit the proliferation of large tumor are developed for inoperable large tumor therapy. The NPs achieve spatially and temporally controlled release of drugs in target sites. The NPs induce the apoptosis of differentiated cancer cells, cancer stem cells, and vascular niches simultaneously. Importantly, the three-pronged NPs inhibit the growth of large tumors without recurrence.
authors.affiliation: State Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing, 100190, P. R. China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Li
authors.affiliation: State Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing, 100190, P. R. China.|Institute of Materials Science and Engineering, Ocean University of China, Qingdao, 266100, P. R. China.
authors.forename: Ruilong
authors.initials: R
authors.lastname: Zhang
authors.affiliation: State Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing, 100190, P. R. China.|University of Chinese Academy of Science, Beijing, 100190, P. R. China.
authors.forename: Zhiguo
authors.initials: Z
authors.lastname: Lu
authors.affiliation: State Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing, 100190, P. R. China.
authors.forename: Guanghui
authors.initials: G
authors.lastname: Ma
authors.affiliation: Department of Obstetrics and Gynecology, Navy General Hospital of People Liberation Army, Beijing, 100048, P. R. China.
authors.forename: Lei
authors.initials: L
authors.lastname: Chen
authors.affiliation: Institute of Materials Science and Engineering, Ocean University of China, Qingdao, 266100, P. R. China. tangqunwei@ouc.edu.cn.
authors.forename: Qunwei
authors.initials: Q
authors.lastname: Tang
authors.affiliation: State Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing, 100190, P. R. China. xzhang@ipe.ac.cn.
authors.forename: Xin
authors.initials: X
authors.lastname: Zhang
mesh_terms: D000818:Animals; D063646:Carcinogenesis / Q000473:pathology; D061307:Human Umbilical Vein Endothelial Cells; D006801:Humans; D061986:MCF-7 Cells; D008819:Mice, Nude; D053758:Nanoparticles / Q000737:chemistry / Q000648:ultrastructure; D009369:Neoplasms / Q000188:drug therapy / Q000473:pathology* / Q000601:surgery / Q000628:therapy*; D014411:Neoplastic Stem Cells / Q000473:pathology*; D059016:Tumor Microenvironment
keywords: cancer stem cells; cancer therapy; hypoxia; inoperable large tumors; three-pronged therapeutic approach; vascular niches