title: A Novel Heterodimer from Crotalaria ferruginea.
abstract: A new compound was isolated from the traditional Chinese folk herb Crotalaria ferruginea. The structure of the new compound was identified as (±)-crotaferruphenol (1) based on analyses of its spectroscopic data including NMR, MS, and specific rotation values. (±)-Crotaferruphenol was a novel heterodimer characteristic of a unique spiroketal moiety, which was produced by the condensation reaction of a chromanone and a 2-isopropenybenzofuran. (±)-Crotaferruphenol exhibited inhibitory activity (IC50 = 6.57 μM.) against phosphodiesterase-4 (PDE4), a drug target for the treatment of chronic obstructive pulmonary disease and asthma.
authors.forename: Yi-Hong
authors.initials: YH
authors.lastname: Zou
authors.forename: Xin
authors.initials: X
authors.lastname: Liu
authors.forename: Ye-Na
authors.initials: YN
authors.lastname: Liu
authors.forename: Gui-Hua
authors.initials: GH
authors.lastname: Tang
authors.forename: Sheng
authors.initials: S
authors.lastname: Yin
mesh_terms: D029864:Crotalaria / Q000737:chemistry*; D019281:Dimerization; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry* / Q000302:isolation & purification
chemical_list: D010936:Plant Extracts