title: Serum fibroblastic growth factor 23 in acute Sarcoidosis and normal kidney function.
abstract: BACKGROUND
  Serum fibroblastic growth factor (FGF) 23 has recently been established as a major physiological regulator of phosphate homeostasis and may have a causal role in adverse cardiovascular and bone outcomes. However its role in states of disordered phosphate homeostasis and normal kidney function is as yet under characterised.
  
  
  OBJECTIVE
  To investigate whether this biomarker of vascular calcification and adverse bone outcomes is detectable in patients with sarcoidosis.
  
  
  METHODS
  We conducted a cross sectional study on a convenience sample of patients presenting with acute sarcoidosis to a respiratory tertiary referral unit.
  
  
  METHODS
  We set out to systematically examine the characteristics and determinants of serum FGF-23 in patients presenting with acute sarcoidosis.
  
  
  RESULTS
  We studied 39 patients, 26 were male. Mean (SD) age was 33 (9.6) years. 15.4% of patients had a serum level of FGF-23 ≥ 9.9 pg/mL. The remaining 84.6% of patients had a serum FGF-23 < 9.9 pg/mL. Those with a detectable serum FGF-23 had a significantly higher serum calcium (P = 0.007), and lower serum iPTH (P<0.001). Serum phosphate and 25-hydroxyvitamin D were not statistically significantly different between groups (P=0.25 and P=0.83). The proportion of patients with stage II disease on CXR was higher in those with a detectable FGF-23 (P<0.001).
  
  
  CONCLUSIONS
  Serum FGF-23 was below the level of detection in the majority of this cohort of patients presenting with acute sarcoidosis. A detectable serum FGF-23 was associated with a higher serum calcium and lower serum iPTH.
authors.affiliation: National University of Ireland Galway.. djm.sexton@gmail.com.
authors.forename: Donal J
authors.initials: DJ
authors.lastname: Sexton
authors.forename: M W
authors.initials: MW
authors.lastname: O'Reilly
authors.forename: P
authors.initials: P
authors.lastname: Geoghegan
authors.forename: S M
authors.initials: SM
authors.lastname: Kinsella
authors.forename: P J
authors.initials: PJ
authors.lastname: Moran
authors.forename: A W
authors.initials: AW
authors.lastname: O'Regan
mesh_terms: D000208:Acute Disease; D000328:Adult; D015415:Biomarkers / Q000097:blood; D002118:Calcium / Q000097:blood; D003430:Cross-Sectional Studies; D005260:Female; D000089703:Fibroblast Growth Factor-23; D005346:Fibroblast Growth Factors / Q000097:blood*; D006801:Humans; D007494:Ireland; D007668:Kidney / Q000502:physiology*; D007677:Kidney Function Tests; D008297:Male; D010281:Parathyroid Hormone / Q000097:blood*; D011237:Predictive Value of Tests; D012507:Sarcoidosis / Q000097:blood* / Q000175:diagnosis / Q000503:physiopathology; D012720:Severity of Illness Index; D062606:Tertiary Care Centers
chemical_list: D015415:Biomarkers; C000717427:FGF23 protein, human; C470125:PTH protein, human; D010281:Parathyroid Hormone; D005346:Fibroblast Growth Factors; D000089703:Fibroblast Growth Factor-23; D002118:Calcium
keywords: FGF-23, sarcoidosis, calcium