title: Dermatological adverse events with taxane chemotherapy.
abstract: Taxanes (docetaxel and paclitaxel) are among the most commonly prescribed anticancer drugs approved for the treatment of metastatic or locally advanced breast, non-small cell lung, prostate, gastric, head and neck, and ovarian cancers, as well as in the adjuvant setting for operable node-positive breast cancers. Although the true incidence of dermatological adverse events (AEs) in patients receiving taxanes is not known, and has never been prospectively analysed, they clearly represent one of the major AEs associated with these agents. With an increase in the occurrence of cutaneous AEs during treatment with novel targeted and immunological therapies when used in combination with taxanes, a thorough understanding of reactions attributable to this class is imperative. Moreover, identification and management of dermatological AEs is critical for maintaining the quality of life in cancer patients and for minimizing dose modifications of their antineoplastic regimen. This analysis represents a systematic review of the dermatological conditions reported with the use of these drugs, complemented by experience at comprehensive cancer centres. The conditions reported herein include skin, hair, and nail toxicities. Lastly, we describe the dermatological data available for the new, recently FDA-and EMA- approved, solvent-free nab-paclitaxel.
authors.affiliation: Departments of Oncodermatology and Clinical Research, Institut Claudius Regaud, Institut Universitaire du Cancer, Toulouse Oncopole, France.
authors.forename: Vincent
authors.initials: V
authors.lastname: Sibaud
authors.affiliation: Department of Dermatology, Dana-Farber/ Brigham and Women's Cancer Center/ Harvard Medical School, Boston, MA, USA.
authors.forename: Nicole R
authors.initials: NR
authors.lastname: Lebœuf
authors.affiliation: Department of Oncology, Institut Claudius Regaud, Institut Universitaire du Cancer, Toulouse Oncopole, France.
authors.forename: Henri
authors.initials: H
authors.lastname: Roche
authors.affiliation: Dermatology Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
authors.forename: Viswanath R
authors.initials: VR
authors.lastname: Belum
authors.affiliation: Department of Oncology, Institut Claudius Regaud, Institut Universitaire du Cancer, Toulouse Oncopole, France.
authors.forename: Laurence
authors.initials: L
authors.lastname: Gladieff
authors.affiliation: Department of Oncology, Institut Claudius Regaud, Institut Universitaire du Cancer, Toulouse Oncopole, France.
authors.forename: Marion
authors.initials: M
authors.lastname: Deslandres
authors.affiliation: Department of Oncology, Institut Claudius Regaud, Institut Universitaire du Cancer, Toulouse Oncopole, France.
authors.forename: Marion
authors.initials: M
authors.lastname: Montastruc
authors.affiliation: Department of Oncology, Institut Claudius Regaud, Institut Universitaire du Cancer, Toulouse Oncopole, France.
authors.forename: Audrey
authors.initials: A
authors.lastname: Eche
authors.affiliation: Department of Oral Medicine, Institut Claudius Regaud, Institut Universitaire du Cancer, Toulouse Oncopole, France.
authors.forename: Emmanuelle
authors.initials: E
authors.lastname: Vigarios
authors.affiliation: Department of Oncology, Institut Claudius Regaud, Institut Universitaire du Cancer, Toulouse Oncopole, France.
authors.forename: Florence
authors.initials: F
authors.lastname: Dalenc
authors.affiliation: Dermatology Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
authors.forename: Mario E
authors.initials: ME
authors.lastname: Lacouture
mesh_terms: D000505:Alopecia / Q000139:chemically induced; D000970:Antineoplastic Agents / Q000009:adverse effects*; D000077143:Docetaxel; D003875:Drug Eruptions / Q000209:etiology*; D004487:Edema / Q000139:chemically induced; D006801:Humans; D008178:Lupus Erythematosus, Cutaneous / Q000139:chemically induced; D009260:Nail Diseases / Q000139:chemically induced; D017239:Paclitaxel / Q000009:adverse effects*; D010859:Pigmentation Disorders / Q000139:chemically induced; D011855:Radiodermatitis / Q000139:chemically induced; D043823:Taxoids / Q000009:adverse effects*
chemical_list: D000970:Antineoplastic Agents; D043823:Taxoids; D000077143:Docetaxel; D017239:Paclitaxel
keywords: docetaxel; hair; nab-paclitaxel; nail; paclitaxel; skin; taxanes; toxicity