title: The First Case Report of Anaphylaxis Caused by the Inclusion Complex of Rocuronium and Sugammadex.
abstract: A 50-year-old man developed a severe anaphylactic reaction shortly after the administration of sugammadex at the end of an uneventful laparoscopic appendectomy. Subsequent skin testing was negative to all agents to which the patient was exposed including sugammadex. Because of the temporal relationship to the administration of sugammadex, further skin testing was performed with premixed sugammadex and rocuronium that produced a markedly positive response. This is the first case report of anergy to the individual components but sensitivity to the inclusion complex of rocuronium and sugammadex. Written informed consent was obtained from the patient for skin testing, photography, laser perfusion imaging, and publication of this case report.
authors.affiliation: From the *Department of Anesthesia, Sir Charles Gairdner Hospital, Nedlands, Australia; ‡Department of Pharmacology, University of Western Australia, Crawley, Western Australia, Australia; and †Anesthetic Allergy Referral Centre of Western Australia, Nedlands, Western Australia, Australia.
authors.forename: Grace
authors.initials: G
authors.lastname: Ho
authors.forename: Russell C
authors.initials: RC
authors.lastname: Clarke
authors.forename: Paul H M
authors.initials: PH
authors.lastname: Sadleir
authors.forename: Peter R
authors.initials: PR
authors.lastname: Platt
mesh_terms: D000707:Anaphylaxis / Q000139:chemically induced* / Q000175:diagnosis*; D000732:Androstanols / Q000008:administration & dosage / Q000009:adverse effects*; D004359:Drug Therapy, Combination / Q000009:adverse effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D009467:Neuromuscular Depolarizing Agents / Q000008:administration & dosage / Q000009:adverse effects*; D000077123:Rocuronium; D000077122:Sugammadex; D047408:gamma-Cyclodextrins / Q000008:administration & dosage / Q000009:adverse effects*
chemical_list: D000732:Androstanols; D009467:Neuromuscular Depolarizing Agents; D047408:gamma-Cyclodextrins; D000077122:Sugammadex; D000077123:Rocuronium