title: Ruthenium-Catalyzed Intramolecular Hydroarylation of Arenes and Mechanistic Study: Synthesis of Dihydrobenzofurans, Indolines, and Chromans.
abstract: A ruthenium-catalyzed, amide-directed intramolecular hydroarylation of alkene-tethered benzamide derivatives is discussed. This method proficiently constructs dihydrobenzofuran, indoline, and chroman skeletons of biological significance in good to excellent yields; the overall process is atom-economical and step-efficient. The reaction exhibits broad scope, tolerating common functional groups, labile protecting units, and heteroaryl motifs. The use of a catalytic amount of base suffices the need. Deuterium scrambling and kinetic studies offer valuable facts for understanding the reaction mechanism.
authors.affiliation: School of Chemistry, University of Hyderabad , Hyderabad 500046, India.
authors.forename: Raja K
authors.initials: RK
authors.lastname: Rit
authors.affiliation: School of Chemistry, University of Hyderabad , Hyderabad 500046, India.
authors.forename: Koushik
authors.initials: K
authors.lastname: Ghosh
authors.affiliation: School of Chemistry, University of Hyderabad , Hyderabad 500046, India.
authors.forename: Rajib
authors.initials: R
authors.lastname: Mandal
authors.affiliation: School of Chemistry, University of Hyderabad , Hyderabad 500046, India.
authors.forename: Akhila K
authors.initials: AK
authors.lastname: Sahoo