title: PD-L2 Elbows out PD-L1 to Rescue T Cell Immunity to Malaria.
abstract: How early interactions between innate and adaptive immune cells influence outcomes of acute infections is incompletely understood. In this issue of Immunity, Karunarathne et al. (2016) show that dendritic cells help CD4(+) T helper 1 cell immunity against malaria through PD-L2's competition with PD-L1.
authors.affiliation: Malaria Infection Biology and Immunity Unit, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, NIH, Rockville, MD 20852, USA.
authors.forename: Peter D
authors.initials: PD
authors.lastname: Crompton
authors.affiliation: Lymphocyte Activation Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, NIH, Rockville, MD 20852, USA. Electronic address: spierce@nih.gov.
authors.forename: Susan K
authors.initials: SK
authors.lastname: Pierce
mesh_terms: D060890:B7-H1 Antigen / Q000276:immunology*; D003713:Dendritic Cells / Q000276:immunology; D006801:Humans; D008213:Lymphocyte Activation / Q000276:immunology; D008288:Malaria; D061027:Programmed Cell Death 1 Ligand 2 Protein
chemical_list: D060890:B7-H1 Antigen; D061027:Programmed Cell Death 1 Ligand 2 Protein