title: The current role and future prospects of D-dimer biomarker.
abstract: D-dimers have been discovered as by-products of fibrinolysis. In situations where the fundamental pathology is associated with increased thrombolytic activity, D-dimer assays could serve an integral role in the clinical workup, and have an already established role in the diagnosis of clinical disorders of venous thromboembolism, and disseminated intravascular coagulation. However, there is growing literature suggesting that this is not the only clinical scenario where D-dimers may be of significance. They may also become an important biomarker in coronary and carotid artery atherosclerosis and aortic diseases. Being a non-invasive and quick means of diagnosis, D-dimers are a cost-effective tool used for diagnosing diseases. With the future being steered in the direction of preventive cardiology, it is imperative for clinicians to understand how to effectively utilize biomarkers in order to diagnose disorders. In this context, we review D-dimer's origin, current clinical utility, and potential future applications.
authors.affiliation: Staten Island University Hospital, 475 Seaview Avenue, Staten Island, NY 10305, USA asoomro@nshs.edu.
authors.forename: Armaghan Y
authors.initials: AY
authors.lastname: Soomro
authors.affiliation: Cardiac Research Foundation, NY111 East 59th Street, 12th Floor, New York, NY 10022, USA.
authors.forename: Alejandra
authors.initials: A
authors.lastname: Guerchicoff
authors.affiliation: Cardiac Research Foundation, NY111 East 59th Street, 12th Floor, New York, NY 10022, USA.
authors.forename: Dru J
authors.initials: DJ
authors.lastname: Nichols
authors.affiliation: Mount Sinai Hospital, 1 Gustave L. Levy Place # 504, New York, NY 10029, USA.
authors.forename: Javed
authors.initials: J
authors.lastname: Suleman
authors.affiliation: Cardiac Research Foundation, NY111 East 59th Street, 12th Floor, New York, NY 10022, USA Mount Sinai Hospital, 1 Gustave L. Levy Place # 504, New York, NY 10029, USA.
authors.forename: George D
authors.initials: GD
authors.lastname: Dangas
mesh_terms: D054058:Acute Coronary Syndrome / Q000097:blood / Q000175:diagnosis*; D000818:Animals; D015415:Biomarkers; D005338:Fibrin Fibrinogen Degradation Products / Q000032:analysis*; D006801:Humans
chemical_list: D015415:Biomarkers; D005338:Fibrin Fibrinogen Degradation Products; C036309:fibrin fragment D
keywords: Acute coronary syndrome; Aortic disorders; Biomarkers