title: Association between rs17095355 polymorphism on 10q24 and susceptibility to biliary atresia: a meta-analysis.
abstract: OBJECTIVE
  Recent studies have identified 10q24-rs17095355 as a susceptibility locus for biliary atresia (BA). To more precisely estimate the association between the rs17095355 polymorphism and BA risk, a meta-analysis was performed.
  
  
  METHODS
  A comprehensive search was conducted to examine all the eligible studies by electronic databases including Elsevier Science Direct, Pubmed, Google Scholar, China National Knowledge Infrastructure (CNKI) and Chinese Biomedical Literature (CBM) up to December 2015. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated to assess the strength of the association.
  
  
  RESULTS
  A total of 6 comparisons from 5 relevant studies involving 1000 patients and 3257 controls were included to analyze the association between rs17095355 and BA risk. The pooled OR for T allele of rs17095355 was 1.72 (95%CI 1.53-1.92, p < 0.01) in BA. Stratification by ethnicity indicated the degree of risk of rs17095355 with BA susceptibility was similar in populations of Asian origin. The pooled OR was 1.81 (95%CI 1.60-2.06, p < 0.01).
  
  
  CONCLUSIONS
  This meta-analysis confirms the association of rs17095355 polymorphism and BA development, especially in Asians. More original studies with large sample are needed to replicate this genetic association in different ethnic groups.
authors.affiliation: a Department of Public Health and General Medicine , Anhui University of Chinese Medicine , Hefei , Anhui , China and.
authors.forename: Jing
authors.initials: J
authors.lastname: Li
authors.affiliation: b Department of Pediatric Surgery , Anhui Provincial Children's Hospital , Hefei , Anhui , China.
authors.forename: Wei
authors.initials: W
authors.lastname: Gao
authors.affiliation: b Department of Pediatric Surgery , Anhui Provincial Children's Hospital , Hefei , Anhui , China.
authors.forename: Wei
authors.initials: W
authors.lastname: Zuo
authors.affiliation: b Department of Pediatric Surgery , Anhui Provincial Children's Hospital , Hefei , Anhui , China.
authors.forename: Xiang
authors.initials: X
authors.lastname: Liu
mesh_terms: D044466:Asian People / Q000235:genetics; D001656:Biliary Atresia / Q000196:embryology / Q000235:genetics*; D016022:Case-Control Studies; D002681:China; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D006801:Humans; D008297:Male; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011247:Pregnancy
keywords: ADD3; Biliary atresia; genetic polymorphism; meta-analysis; rs17095355