title: Hemorrhagic Herpes Simplex Virus Type 1 Nephritis: An Unusual Cause of Acute Allograft Dysfunction.
abstract: Interstitial nephritis due to viruses is well-described after solid organ transplantation. Viruses implicated include cytomegalovirus; BK polyomavirus; Epstein-Barr virus; and, less commonly, adenovirus. We describe a rare case of hemorrhagic allograft nephritis due to herpes simplex virus type 1 at 10 days after living donor kidney transplantation. The patient had a favorable outcome with intravenous acyclovir and reduction of immunosuppression.
authors.affiliation: Division of Infectious Diseases, Department of Medicine, Duke University Medical Center, Durham, NC.
authors.forename: M
authors.initials: M
authors.lastname: Hemmersbach-Miller
authors.affiliation: Division of Nephrology, Department of Medicine, Duke University Medical Center, Durham, NC.
authors.forename: J
authors.initials: J
authors.lastname: Duronville
authors.affiliation: Division of Nephrology, Department of Medicine, Duke University Medical Center, Durham, NC.
authors.forename: S
authors.initials: S
authors.lastname: Sethi
authors.affiliation: Department of Pathology, Duke University Medical Center, Durham, NC.
authors.forename: S E
authors.initials: SE
authors.lastname: Miller
authors.affiliation: Department of Pathology, Duke University Medical Center, Durham, NC.
authors.forename: D N
authors.initials: DN
authors.lastname: Howell
authors.affiliation: Clinical Microbiology Laboratory, Duke University Medical Center, Durham, NC.
authors.forename: N
authors.initials: N
authors.lastname: Henshaw
authors.affiliation: Division of Infectious Diseases, Department of Medicine, Duke University Medical Center, Durham, NC.
authors.forename: B D
authors.initials: BD
authors.lastname: Alexander
authors.affiliation: Division of Nephrology, Department of Medicine, Duke University Medical Center, Durham, NC.
authors.forename: J K
authors.initials: JK
authors.lastname: Roberts
mesh_terms: D000212:Acyclovir / Q000627:therapeutic use; D064591:Allografts; D000998:Antiviral Agents / Q000627:therapeutic use; D005919:Glomerular Filtration Rate; D006084:Graft Rejection / Q000209:etiology* / Q000473:pathology; D006085:Graft Survival; D006470:Hemorrhage / Q000188:drug therapy / Q000821:virology*; D006561:Herpes Simplex / Q000150:complications*; D018259:Herpesvirus 1, Human / Q000472:pathogenicity*; D006801:Humans; D007165:Immunosuppression Therapy; D007676:Kidney Failure, Chronic / Q000601:surgery*; D007677:Kidney Function Tests; D016030:Kidney Transplantation / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D009393:Nephritis / Q000188:drug therapy / Q000821:virology*; D011379:Prognosis; D012307:Risk Factors
chemical_list: D000998:Antiviral Agents; D000212:Acyclovir
keywords: clinical research/practice; donors and donation; infection and infectious agents; infectious disease; kidney disease: infectious; kidney transplantation/nephrology; kidney transplantation: living donor; viral