title: Adenoid cystic carcinoma of the urethra/Cowper's gland with concurrent high-grade prostatic adenocarcinoma: a detailed clinicopathologic case report and review of the literature.
abstract: Primary adenoid cystic carcinoma of the urethra is uncommon with only 9 cases reported in the medical literature; all tumors arose from Cowper's glands. Herein, we report the histological features and immunohistochemical characteristics of 1 patient with primary adenoid cystic carcinoma involving the entire posterior urethra, prostate gland, corpus spongiosum, corpora cavernosa, urogenital diaphragm, perianal soft tissue, and muscularis propria layer of rectum. We also review other published cases to evaluate the prognosis and treatment.
authors.affiliation: Department of Pathology, The University of Texas, MD Anderson Cancer Center, Houston, TX 77030. Electronic address: mzhang8@mdanderson.org.
authors.forename: Miao
authors.initials: M
authors.lastname: Zhang
authors.affiliation: Department of Urology, The University of Texas, MD Anderson Cancer Center, Houston, TX 77030.
authors.forename: Curtis
authors.initials: C
authors.lastname: Pettaway
authors.affiliation: Department of Radiology, The University of Texas, MD Anderson Cancer Center, Houston, TX 77030.
authors.forename: Raghu
authors.initials: R
authors.lastname: Vikram
authors.affiliation: Department of Pathology, The University of Texas, MD Anderson Cancer Center, Houston, TX 77030.
authors.forename: Pheroze
authors.initials: P
authors.lastname: Tamboli
mesh_terms: D000230:Adenocarcinoma / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis; D001706:Biopsy; D002030:Bulbourethral Glands / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D003528:Carcinoma, Adenoid Cystic / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D006801:Humans; D007150:Immunohistochemistry; D008279:Magnetic Resonance Imaging; D008297:Male; D060787:Neoplasm Grading; D009378:Neoplasms, Multiple Primary / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D011471:Prostatic Neoplasms / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D018714:Radiotherapy, Adjuvant; D016896:Treatment Outcome; D014523:Urethral Neoplasms / Q000737:chemistry / Q000473:pathology* / Q000601:surgery
chemical_list: D014408:Biomarkers, Tumor
keywords: Adenoid cystic carcinoma; Basaloid carcinoma; Cowper's gland; Prostatic adenocarcinoma; Urethra