title: Autophagy-independent function of Atg1 for apoptosis-induced compensatory proliferation.
abstract: ATG1 belongs to the Uncoordinated-51-like kinase protein family. Members of this family are best characterized for roles in macroautophagy and neuronal development. Apoptosis-induced proliferation (AiP) is a caspase-directed and JNK-dependent process which is involved in tissue repair and regeneration after massive stress-induced apoptotic cell loss. Under certain conditions, AiP can cause tissue overgrowth with implications for cancer.
  
  
  
  Here, we show that Atg1 in Drosophila (dAtg1) has a previously unrecognized function for both regenerative and overgrowth-promoting AiP in eye and wing imaginal discs. dAtg1 acts genetically downstream of and is transcriptionally induced by JNK activity, and it is required for JNK-dependent production of mitogens such as Wingless for AiP. Interestingly, this function of dAtg1 in AiP is independent of its roles in autophagy and in neuronal development.
  
  
  
  In addition to a role of dAtg1 in autophagy and neuronal development, we report a third function of dAtg1 for AiP.
authors.affiliation: University of Birmingham, School of Biosciences, Edgbaston, Birmingham, B15 2TT, UK.
authors.forename: Mingli
authors.initials: M
authors.lastname: Li
authors.affiliation: Department of Molecular, Cell and Cancer Biology, University of Massachusetts Medical School, 364 Plantation Street, LRB419, Worcester, MA, 01605, USA.
authors.forename: Jillian L
authors.initials: JL
authors.lastname: Lindblad
authors.affiliation: Department of Molecular, Cell and Cancer Biology, University of Massachusetts Medical School, 364 Plantation Street, LRB419, Worcester, MA, 01605, USA.
authors.forename: Ernesto
authors.initials: E
authors.lastname: Perez
authors.affiliation: Department of Molecular, Cell and Cancer Biology, University of Massachusetts Medical School, 364 Plantation Street, LRB419, Worcester, MA, 01605, USA. andreas.bergmann@umassmed.edu.
authors.forename: Andreas
authors.identifier: 0000-0002-9134-871X
authors.initials: A
authors.lastname: Bergmann
authors.affiliation: University of Birmingham, School of Biosciences, Edgbaston, Birmingham, B15 2TT, UK. y.fan@bham.ac.uk.
authors.forename: Yun
authors.initials: Y
authors.lastname: Fan
mesh_terms: D000818:Animals; D017209:Apoptosis; D001343:Autophagy; D000071189:Autophagy-Related Protein-1 Homolog / Q000235:genetics / Q000378:metabolism*; D049109:Cell Proliferation; D004330:Drosophila / Q000235:genetics* / Q000378:metabolism; D029721:Drosophila Proteins / Q000235:genetics / Q000378:metabolism*; D005123:Eye / Q000254:growth & development; D060227:Imaginal Discs / Q000254:growth & development; D020935:MAP Kinase Signaling System; D015533:Transcriptional Activation; D014921:Wings, Animal / Q000254:growth & development
chemical_list: D029721:Drosophila Proteins; C518074:Atg1 protein, Drosophila; D000071189:Autophagy-Related Protein-1 Homolog
keywords: Apoptosis-induced proliferation; Atg1; Autophagy; Jun-N-terminal kinase signaling; ULK1/2