title: Acute leg ischaemia in an HIV-infected patient receiving antiretroviral treatment.
abstract: An HIV-infected patient treated with tenofovir disoproxil fumarate/emtricitabine/elvitegravir/cobicistat developed severe acute ischaemia of both legs during a migraine episode. After being interrogated he admitted taking an ergotamine-containing preparation. Ergotism due to interaction between ergotics and cobicistat was diagnosed. We describe the first reported case of this interaction.
authors.affiliation: Infectious Diseases Department, Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, Barcelona, Spain.|Vall d'Hebron Research Institute, Barcelona, Spain.
authors.forename: Jordi
authors.initials: J
authors.lastname: Navarro
authors.affiliation: Infectious Diseases Department, Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, Barcelona, Spain.|Vall d'Hebron Research Institute, Barcelona, Spain.
authors.forename: Adrian
authors.initials: A
authors.lastname: Curran
authors.affiliation: Infectious Diseases Department, Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, Barcelona, Spain.|Vall d'Hebron Research Institute, Barcelona, Spain.
authors.forename: Joaquin
authors.initials: J
authors.lastname: Burgos
authors.affiliation: Vall d'Hebron Research Institute, Barcelona, Spain.
authors.forename: Ariadna
authors.initials: A
authors.lastname: Torrella
authors.affiliation: Infectious Diseases Department, Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, Barcelona, Spain.
authors.forename: Inma
authors.initials: I
authors.lastname: Ocaña
authors.affiliation: Infectious Diseases Department, Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, Barcelona, Spain.|Vall d'Hebron Research Institute, Barcelona, Spain.
authors.forename: Vicenç
authors.initials: V
authors.lastname: Falcó
authors.affiliation: Infectious Diseases Department, Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, Barcelona, Spain.|Vall d'Hebron Research Institute, Barcelona, Spain.
authors.forename: Manuel
authors.initials: M
authors.lastname: Crespo
authors.affiliation: Infectious Diseases Department, Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, Barcelona, Spain.|Vall d'Hebron Research Institute, Barcelona, Spain.
authors.forename: Esteban
authors.initials: E
authors.lastname: Ribera
mesh_terms: D000208:Acute Disease; D000328:Adult; D019380:Anti-HIV Agents / Q000008:administration & dosage / Q000009:adverse effects*; D000069547:Cobicistat / Q000008:administration & dosage / Q000009:adverse effects*; D004347:Drug Interactions; D004359:Drug Therapy, Combination; D004878:Ergotamine / Q000008:administration & dosage / Q000009:adverse effects*; D015658:HIV Infections / Q000150:complications* / Q000188:drug therapy*; D006801:Humans; D007511:Ischemia / Q000209:etiology*; D007866:Leg; D008297:Male; D008881:Migraine Disorders / Q000150:complications / Q000188:drug therapy
chemical_list: D019380:Anti-HIV Agents; D000069547:Cobicistat; D004878:Ergotamine