title: Dr Eng M. Tan: a tribute to an enduring legacy in autoimmunity.
abstract: At the age of ninety years, Dr Eng Meng Tan has had a remarkable impact on the accumulated knowledge of autoimmune diseases, including seminal findings in systemic lupus erythematosus (SLE) and a wide range of other autoimmune diseases. Dating to the first description of the Sm (Smith) autoantibody in SLE, his focus has been the use of autoantibodies as probes to identify and elucidate novel cellular molecules and then translating these discoveries into biomarkers and immunoassays for a wide range of these diseases and, later, cancer. He led efforts to standardize autoantibody nomenclature and testing protocols. Through his mentorship a great number of trainees and collaborators have had remarkably successful careers, and by that virtue he has garnered a remarkable continuing legacy.
authors.affiliation: 1 University of Calgary, Cumming School of Medicine, Calgary, Canada.
authors.forename: M J
authors.initials: MJ
authors.lastname: Fritzler
authors.affiliation: 2 Department of Oral Biology, University of Florida, Gainesville, USA.
authors.forename: E K L
authors.initials: EKL
authors.lastname: Chan
mesh_terms: D000486:Allergy and Immunology / Q000193:education / Q000266:history*; D001323:Autoantibodies / Q000266:history* / Q000276:immunology; D001327:Autoimmune Diseases / Q000266:history* / Q000276:immunology; D015551:Autoimmunity; D035843:Biomedical Research / Q000266:history*; D004501:Education, Medical / Q000266:history; D049673:History, 20th Century; D049674:History, 21st Century; D006801:Humans; D008611:Mentors / Q000266:history; D014481:United States
chemical_list: D001323:Autoantibodies
keywords: Autoantibodies; autoantigens; systemic autoimmune rheumatic diseases; systemic lupus erythematosus