title: Characterization of the new GII.17 norovirus variant that emerged recently as the predominant strain in China.
abstract: Human noroviruses are the most important viral pathogens causing epidemic acute gastroenteritis, in which the GII.4 viruses have been predominant worldwide for the past decades. During 2014-2015 winter season, a new GII.17 variant emerged as the predominant virus in China surpassing the GII.4 virus in causing significantly increased acute gastroenteritis outbreaks. Genome sequences of the new GII.17 variant was determined and compared with other GII.17 noroviruses, revealing residue substitutions at specific locations, including the histo-blood group antigen-binding site and the putative antigenic epitopes. Further study of GII.17 outbreaks focusing on host susceptibility showed that the new GII.17 variant infected secretor individuals of A, B, O and Lewis types. Accordingly, the P particles of the new GII.17 variant bound secretor saliva samples of A, B, O and Lewis types with significantly higher binding signals than those of the P particles of the previous GII.17 variants. In addition, human sera collected from the outbreaks exhibited stronger blockade against the binding of the new GII.17 P particles to saliva samples than those against the binding between the P particles of previous GII.17 variants and saliva samples. Taken together, our data strongly suggested that the new GII.17 variant gained new histo-blood group antigen-binding ability and antigenic features, which may contribute to its predominance in causing human norovirus epidemics.
authors.affiliation: Key Laboratory of Medical Virology and Viral Diseases, Ministry of Health of the People's Republic of China, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, PR China.
authors.forename: Miao
authors.initials: M
authors.lastname: Jin
authors.affiliation: Key Laboratory of Medical Virology and Viral Diseases, Ministry of Health of the People's Republic of China, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, PR China.|The First Clinical Medical College of Lanzhou University, Lanzhou, PR China.
authors.forename: Yong-Kang
authors.initials: YK
authors.lastname: Zhou
authors.affiliation: Guangzhou Center for Disease Control and Prevention, Guangzhou, Guangdong Province, PR China.
authors.forename: Hua-Ping
authors.initials: HP
authors.lastname: Xie
authors.affiliation: Jiangsu Provincial Center for Disease Control and Prevention, Jiangsu Province, PR China.
authors.forename: Jian-Guang
authors.initials: JG
authors.lastname: Fu
authors.affiliation: Shenzhen Center for Disease Control and Prevention, Shenzhen, Guangdong Province, PR China.
authors.forename: Ya-Qing
authors.initials: YQ
authors.lastname: He
authors.affiliation: Beijing Shunyi Center for Disease Control and Prevention, Shunyi District, Beijing, PR China.
authors.forename: Shuang
authors.initials: S
authors.lastname: Zhang
authors.affiliation: Beijing Shunyi Center for Disease Control and Prevention, Shunyi District, Beijing, PR China.
authors.forename: Hong-Bo
authors.initials: HB
authors.lastname: Jing
authors.affiliation: Key Laboratory of Medical Virology and Viral Diseases, Ministry of Health of the People's Republic of China, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, PR China.
authors.forename: Xiang-Yu
authors.initials: XY
authors.lastname: Kong
authors.affiliation: Key Laboratory of Medical Virology and Viral Diseases, Ministry of Health of the People's Republic of China, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, PR China.
authors.forename: Xiao-Man
authors.initials: XM
authors.lastname: Sun
authors.affiliation: Key Laboratory of Medical Virology and Viral Diseases, Ministry of Health of the People's Republic of China, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, PR China.
authors.forename: Hui-Ying
authors.initials: HY
authors.lastname: Li
authors.affiliation: Key Laboratory of Medical Virology and Viral Diseases, Ministry of Health of the People's Republic of China, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, PR China.
authors.forename: Qing
authors.initials: Q
authors.lastname: Zhang
authors.affiliation: Guangzhou Huadu Center for Disease Control and Prevention, Huadu District, Guangzhou, Guangdong Province, PR China.
authors.forename: Kai
authors.initials: K
authors.lastname: Li
authors.affiliation: Guangzhou Huadu Center for Disease Control and Prevention, Huadu District, Guangzhou, Guangdong Province, PR China.
authors.forename: Ying-Jun
authors.initials: YJ
authors.lastname: Zhang
authors.affiliation: Guangzhou Yuexiu Center for Disease Control and Prevention, Yuexiu District, Guangzhou, Guangdong Province, PR China.
authors.forename: De-Qian
authors.initials: DQ
authors.lastname: Zhou
authors.affiliation: Division of Infectious Disease, Key Laboratory of Surveillance and Early Warning on Infectious Disease, Chinese Center for Disease Control and Prevention, Beijing, PR China.
authors.forename: Wei-Jia
authors.initials: WJ
authors.lastname: Xing
authors.affiliation: Division of Infectious Disease, Key Laboratory of Surveillance and Early Warning on Infectious Disease, Chinese Center for Disease Control and Prevention, Beijing, PR China.
authors.forename: Qiao-Hong
authors.initials: QH
authors.lastname: Liao
authors.affiliation: Division of Infectious Disease, Key Laboratory of Surveillance and Early Warning on Infectious Disease, Chinese Center for Disease Control and Prevention, Beijing, PR China.
authors.forename: Na
authors.initials: N
authors.lastname: Liu
authors.affiliation: Division of Infectious Disease, Key Laboratory of Surveillance and Early Warning on Infectious Disease, Chinese Center for Disease Control and Prevention, Beijing, PR China.
authors.forename: Hong-Jie
authors.initials: HJ
authors.lastname: Yu
authors.affiliation: Divisions of Infectious Diseases, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.|Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
authors.forename: Xi
authors.initials: X
authors.lastname: Jiang
authors.affiliation: Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.|Divisions of Infectious Diseases, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
authors.forename: Ming
authors.initials: M
authors.lastname: Tan
authors.affiliation: Key Laboratory of Medical Virology and Viral Diseases, Ministry of Health of the People's Republic of China, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, PR China.
authors.forename: Zhao-Jun
authors.initials: ZJ
authors.lastname: Duan
mesh_terms: D001789:Blood Group Antigens / Q000235:genetics / Q000378:metabolism; D017250:Caliciviridae Infections / Q000453:epidemiology / Q000235:genetics / Q000378:metabolism / Q000821:virology*; D002681:China / Q000453:epidemiology; D004196:Disease Outbreaks; D019143:Evolution, Molecular; D005243:Feces / Q000821:virology; D005759:Gastroenteritis / Q000453:epidemiology / Q000821:virology; D006801:Humans; D029322:Norovirus / Q000145:classification / Q000235:genetics / Q000302:isolation & purification*; D010802:Phylogeny
chemical_list: D001789:Blood Group Antigens