title: Investigational and experimental drugs for intraocular pressure reduction in ocular hypertension and glaucoma.
abstract: BACKGROUND
  Intraocular pressure (IOP) is the most significant modifiable risk factor to prevent onset or progression of glaucoma. Glaucoma prevalence continues to increase, emphasizing the need for improved ocular hypotensive treatment options. To try to improve on both tolerance and IOP control of currently available therapies, different receptors or mechanisms are being explored to reduce IOP more effectively and to improve tolerance.
  
  
  METHODS
  We review synthetic topical and oral drugs in early development for the management of ocular hypertension and glaucoma.
  
  
  CONCLUSIONS
  New therapeutic agents for IOP control have been discovered; some appear to be reasonably tolerated. IOP reduction may be limited with some agents, but other benefits although unproven may compensate for this, such as less ocular surface disease, enhanced neuro-protection or increased ocular blood flow. Further product development promises improved treatment options for ocular hypertensives and glaucoma sufferers.
authors.affiliation: a Discipline of Ophthalmology , University of Sydney , Sydney , Australia.|b Glaucoma Unit , Sydney Eye Hospital , Sydney , Australia.
authors.forename: Jed Asher
authors.initials: JA
authors.lastname: Lusthaus
authors.affiliation: a Discipline of Ophthalmology , University of Sydney , Sydney , Australia.|b Glaucoma Unit , Sydney Eye Hospital , Sydney , Australia.|c Eye Associates , Sydney , Australia.
authors.forename: Ivan
authors.initials: I
authors.lastname: Goldberg
mesh_terms: D000818:Animals; D000959:Antihypertensive Agents / Q000008:administration & dosage* / Q000494:pharmacology / Q000627:therapeutic use; D018450:Disease Progression; D015195:Drug Design; D015507:Drugs, Investigational / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D005901:Glaucoma / Q000188:drug therapy* / Q000473:pathology / Q000517:prevention & control; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects; D009798:Ocular Hypertension / Q000150:complications / Q000188:drug therapy*
chemical_list: D000959:Antihypertensive Agents; D015507:Drugs, Investigational
keywords: Ocular hypertension; compliance; glaucoma; open angle glaucoma