title: [A clinical study of invasive fungal disease in children without underlying diseases].
abstract: OBJECTIVE
  To investigate the clinical features of invasive fungal disease (IFD) in children without underlying diseases.
  
  
  METHODS
  The clinical data of 49 children without underlying diseases who were diagnosed with IFD were retrospectively studied.
  
  
  RESULTS
  Fungal pathogens were detected in 37 (76%) out of 49 patients, including Cryptococcus neoformans (17 children, 46%), Candida albicans (10 children, 27%), Aspergillus (3 children, 8%), and Candida parapsilosis (3 children, 8%). Fungal pneumonia (17 children, 46%) was the most commonly seen disease, with Candida albicans as the major pathogen (9 children, 53%). The 49 children had at least one high-risk factor for infection, including the use of antibiotics, a long length of hospital stay, and invasive procedures. Of all the children, 82% did not respond well to antibiotic treatment or experienced recurrent pyrexia. Among the 24 children who underwent G tests, 17 (71%) showed positive results. All the children were given antifungal therapy, and among these children, 37 (75%)were cured, 3 (6%) were still in the treatment, 5 (10%) died, and 4 (8%) were lost to follow-up.
  
  
  CONCLUSIONS
  In IFD children without underlying diseases, Cryptococcus neoformans and Candida are the main pathogens, and lung infection is the most common disease. Long-term use of high-dose antibiotics may be an important risk factor for fungal infection. The IFD children without underlying diseases are sensitive to antifungal drugs and have a satisfactory prognosis.
authors.affiliation: Department of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu 610041, China. wcm0220@sina.com.
authors.forename: Wei-Ran
authors.initials: WR
authors.lastname: Li
authors.forename: Si-Yan
authors.initials: SY
authors.lastname: Deng
authors.forename: Min
authors.initials: M
authors.lastname: Shu
authors.forename: Yu
authors.initials: Y
authors.lastname: Zhu
authors.forename: Yang
authors.initials: Y
authors.lastname: Wen
authors.forename: Qin
authors.initials: Q
authors.lastname: Guo
authors.forename: Qiong
authors.initials: Q
authors.lastname: Liao
authors.forename: Chao-Min
authors.initials: CM
authors.lastname: Wan
mesh_terms: D000293:Adolescent; D000935:Antifungal Agents / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D000072742:Invasive Fungal Infections / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D008297:Male; D012307:Risk Factors
chemical_list: D000935:Antifungal Agents