title: Solid-in-oil nanodispersions for transdermal drug delivery systems.
abstract: Transdermal administration of drugs has advantages over conventional oral administration or administration using injection equipment. The route of administration reduces the opportunity for drug evacuation before systemic circulation, and enables long-lasting drug administration at a modest body concentration. In addition, the skin is an attractive route for vaccination, because there are many immune cells in the skin. Recently, solid-in-oil nanodisperison (S/O) technique has demonstrated to deliver cosmetic and pharmaceutical bioactives efficiently through the skin. S/O nanodispersions are nanosized drug carriers designed to overcome the skin barrier. This review discusses the rationale for preparation of efficient and stable S/O nanodispersions, as well as application examples in cosmetic and pharmaceutical materials including vaccines. Drug administration using a patch is user-friendly, and may improve patient compliance. The technique is a potent transcutaneous immunization method without needles.
authors.affiliation: Graduate School of Engineering, Kyushu University, Fukuoka, Japan.
authors.forename: Momoko
authors.initials: M
authors.lastname: Kitaoka
authors.affiliation: Graduate School of Engineering, Kyushu University, Fukuoka, Japan.|Center for Transdermal Drug Delivery, Kyushu University, Fukuoka, Japan.
authors.forename: Rie
authors.initials: R
authors.lastname: Wakabayashi
authors.affiliation: Graduate School of Engineering, Kyushu University, Fukuoka, Japan.|Center for Transdermal Drug Delivery, Kyushu University, Fukuoka, Japan.|Center for Future Chemistry, Kyushu University, Fukuoka, Japan.
authors.forename: Noriho
authors.initials: N
authors.lastname: Kamiya
authors.affiliation: Graduate School of Engineering, Kyushu University, Fukuoka, Japan.|Center for Transdermal Drug Delivery, Kyushu University, Fukuoka, Japan.|Center for Future Chemistry, Kyushu University, Fukuoka, Japan.
authors.forename: Masahiro
authors.initials: M
authors.lastname: Goto
mesh_terms: D000279:Administration, Cutaneous; D016503:Drug Delivery Systems; D006801:Humans; D049329:Nanostructures / Q000627:therapeutic use; D012867:Skin / Q000187:drug effects* / Q000276:immunology; D014611:Vaccination / Q000379:methods*
keywords: Nanocarrier; Solid-in-oil nanodispersion; Transcutaneous immunotherapy; Transdermal drug delivery; Vaccine