title: The relationship between left ventricular mass and insulin resistance in obese patients.
abstract: OBJECTIVE
  In this study, we investigated the relationship between left ventricular mass and insulin resistance in obese patients.
  
  
  METHODS
  A total of 90 subjects, 66 women, and 24 men, with an age range from 24 to 56 years, were enrolled in the study. Forty-nine patients were in the obesity group whose body mass index (BMI) was >29.9kg/m(2) and 41 subjects were in the control group with a BMI <25kg/m(2). All of them were normotensive, nondiabetic, and did not have any cardiovascular disease. They were not taking any medication. Weight, height, and waist circumference were measured and BMI was calculated. Plasma glucose, insulin, serum total, high-density lipoprotein (HDL) and low-density lipoprotein (LDL) cholesterol, and triglyceride levels were measured, and insulin resistance was calculated via homeostasis model of assessment-estimated insulin resistance (HOMA-IR). Subjects were examined by echocardiography and left ventricular mass (LVM) and index (LVMI) were calculated with Devereux formula.
  
  
  RESULTS
  Insulin levels, HOMA-IR, LVM, and LVMI were significantly higher in obesity group (p<0.01). Fasting glucose, triglyceride, fasting insulin levels, and waist circumference did not correlate with LVMI.
  
  
  CONCLUSIONS
  In conclusion, though findings of the present study suggest increased left ventricular hypertrophy (LVH) in obese subjects compared to controls, it appears that the increased LVM or LVH is not linked to BMI and insulin resistance in this study population.
authors.affiliation: 2nd Clinic of Internal Medicine, Okmeydani Training and Research Hospital, Istanbul, Turkey.
authors.forename: Cengiz
authors.initials: C
authors.lastname: Bulut
authors.affiliation: 2nd Clinic of Internal Medicine, Okmeydani Training and Research Hospital, Istanbul, Turkey.
authors.forename: Aysen
authors.initials: A
authors.lastname: Helvaci
authors.affiliation: 2nd Clinic of Internal Medicine, Okmeydani Training and Research Hospital, Istanbul, Turkey.
authors.forename: Mine
authors.initials: M
authors.lastname: Adas
authors.affiliation: 2nd Clinic of Internal Medicine, Okmeydani Training and Research Hospital, Istanbul, Turkey.
authors.forename: Neslihan
authors.initials: N
authors.lastname: Ozsoy
authors.affiliation: 2nd Clinic of Internal Medicine, Okmeydani Training and Research Hospital, Istanbul, Turkey. Electronic address: akif.bayyigit@gmail.com.
authors.forename: Akif
authors.initials: A
authors.lastname: Bayyigit
mesh_terms: D000328:Adult; D001786:Blood Glucose / Q000378:metabolism; D015992:Body Mass Index; D004452:Echocardiography; D005260:Female; D006352:Heart Ventricles / Q000000981:diagnostic imaging / Q000503:physiopathology*; D006801:Humans; D017379:Hypertrophy, Left Ventricular / Q000453:epidemiology / Q000209:etiology* / Q000503:physiopathology; D015994:Incidence; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000097:blood / Q000150:complications* / Q000453:epidemiology; D009929:Organ Size; D012307:Risk Factors; D014421:Turkey / Q000453:epidemiology; D016277:Ventricular Function, Left / Q000502:physiology*; D055815:Young Adult
chemical_list: D001786:Blood Glucose; D007328:Insulin
keywords: Echocardiography; Insulin resistance; Left ventricular mass; Obesity