title: A new ent-kaurane diterpene from Euphorbia stracheyi Boiss.
abstract: The chemical investigation of whole plants Euphorbia stracheyi Boiss from China led to the isolation of one new ent-kaurane diterpene, ent-Kaurane-16β,17,19-triol-3-one (1), along with three known ent-kaurane diterpenoids (2-4) as ent-Kaurane-3α,16β,17-triol (2)，ent-16S,17-dihydroxy-kaurane-3-one (3) and ent-3S,16S,17-trihydroxy-kaurane-2-one (4). Their structures were elucidated by extensive spectroscopic analyses including 1D, 2D NMR, HR-ESI-MS, and by comparison with the literature. Compound 2 was a new natural product and firstly isolated from nature, while compounds (3-4) were isolated from E. stracheyi for the first time. All isolated compounds (1-4) were evaluated for their cytotoxic activities against five human cancer cell lines (including A-549, SMMC-7721, HL-60, MCF-7 and SW-480).
authors.affiliation: a Key Laboratory for Forest Resources Conservation and Utilization in the Southwest Mountains of China , Ministry of Education, Southwest Forestry University , Kunming , P.R. China.
authors.forename: Tie
authors.initials: T
authors.lastname: Liu
authors.affiliation: a Key Laboratory for Forest Resources Conservation and Utilization in the Southwest Mountains of China , Ministry of Education, Southwest Forestry University , Kunming , P.R. China.|b Department of Medicinal Plant, School of Forestry , Southwest Forestry University , Kunming , P.R. China.
authors.forename: Qian
authors.initials: Q
authors.lastname: Liang
authors.affiliation: a Key Laboratory for Forest Resources Conservation and Utilization in the Southwest Mountains of China , Ministry of Education, Southwest Forestry University , Kunming , P.R. China.
authors.forename: Na-Na
authors.initials: NN
authors.lastname: Xiong
authors.affiliation: a Key Laboratory for Forest Resources Conservation and Utilization in the Southwest Mountains of China , Ministry of Education, Southwest Forestry University , Kunming , P.R. China.
authors.forename: Lin-Feng
authors.initials: LF
authors.lastname: Dai
authors.affiliation: a Key Laboratory for Forest Resources Conservation and Utilization in the Southwest Mountains of China , Ministry of Education, Southwest Forestry University , Kunming , P.R. China.|b Department of Medicinal Plant, School of Forestry , Southwest Forestry University , Kunming , P.R. China.
authors.forename: Jun-Ming
authors.initials: JM
authors.lastname: Wang
authors.affiliation: c Department of Applied Chemistry, School of Chemistry and Environment Science , Shaanxi University of Technology , Hanzhong , P.R. China.
authors.forename: Xiao-Hui
authors.initials: XH
authors.lastname: Ji
authors.affiliation: a Key Laboratory for Forest Resources Conservation and Utilization in the Southwest Mountains of China , Ministry of Education, Southwest Forestry University , Kunming , P.R. China.
authors.forename: Wen-Hui
authors.initials: WH
authors.lastname: Xu
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D016923:Cell Death / Q000187:drug effects; D045744:Cell Line, Tumor; D002681:China; D045786:Diterpenes, Kaurane / Q000737:chemistry / Q000302:isolation & purification*; D028481:Euphorbia / Q000737:chemistry*; D006801:Humans; D015394:Molecular Structure; D013057:Spectrum Analysis
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D045786:Diterpenes, Kaurane
keywords: Euphorbia stracheyi; diterpenoid; ent-kaurane