title: Vertebral artery hypoplasia, posterior circulation infarction and relative hypoperfusion detected by perfusion magnetic resonance imaging semiquantitatively.
abstract: Vertebral artery hypoplasia (VAH) has been considered a risk factor of posterior circulation infarction (PCI), especially in the territory of the posterior inferior cerebellar artery (PICA). But whether VAH is an independent risk factor for PCI remains uncertain and how VAH participates in the evolvement of PCI is still not clear either. Therefore, this study aims to examine whether VAH is an independent risk factor for PCI and evaluate the effect of VAH on the cerebral perfusion in the territory of the PICA detected by perfusion magnetic resonance imaging (MRI) semiquantitatively. Both univariate and multivariate analyses showed that VAH, hypertension and smoking were more frequent in patients with PCI than in patients without PCI. Perfusion MRI analysis found that there were remarkable differences in the frequency of the relative cerebral blood flow (rCBF) value ≤0.85 and the relative time to peak (rTTP) values between VAH patients without PCI and non-VAH patients without PCI. Our results indicated that VAH may be an independent risk factor for PCI, especially in the presence of hypertension and smoking and that a relative hypoperfusion associates with VAH that may contribute to the evolvement of the infarction in the PICA territory.
authors.affiliation: Department of Neurology, Zhengzhou People's Hospital, Zhengzhou, 450003, PR China.
authors.forename: Dao Pei
authors.initials: DP
authors.lastname: Zhang
authors.affiliation: Department of Neurology, People's Hospital of Zhengzhou University, Zhengzhou, 450003, PR China.
authors.forename: Qian Kun
authors.initials: QK
authors.lastname: Ma
authors.affiliation: Department of Neurology, People's Hospital of Zhengzhou University, Zhengzhou, 450003, PR China. Electronic address: zhangjiewen9900@126.com.
authors.forename: Jie Wen
authors.initials: JW
authors.lastname: Zhang
authors.affiliation: Department of Neurology, Zhengzhou People's Hospital, Zhengzhou, 450003, PR China. Electronic address: zsl66317@163.com.
authors.forename: Shu Ling
authors.initials: SL
authors.lastname: Zhang
authors.affiliation: Department of Neurology, People's Hospital of Zhengzhou University, Zhengzhou, 450003, PR China.
authors.forename: Gui Feng
authors.initials: GF
authors.lastname: Lu
authors.affiliation: Department of CT and MRI, Zhengzhou People's Hospital, Zhengzhou, 450003, PR China.
authors.forename: Suo
authors.initials: S
authors.lastname: Yin
mesh_terms: D002560:Cerebrovascular Circulation / Q000502:physiology; D003287:Contrast Media; D038524:Diffusion Magnetic Resonance Imaging; D005260:Female; D006760:Hospitalization; D006801:Humans; D006973:Hypertension / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000628:therapy; D018810:Magnetic Resonance Angiography / Q000379:methods*; D008297:Male; D008875:Middle Aged; D012907:Smoking / Q000503:physiopathology; D020521:Stroke / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000628:therapy; D014711:Vertebral Artery / Q000000981:diagnostic imaging* / Q000503:physiopathology; D014715:Vertebrobasilar Insufficiency / Q000000981:diagnostic imaging* / Q000503:physiopathology / Q000628:therapy
chemical_list: D003287:Contrast Media
keywords: Magnetic resonance; Perfusion weighted imaging; Posterior circulation; Stroke; Vertebral artery; hypoplasia