title: The chemical biology of HNO signaling.
abstract: Nitroxyl (HNO) is a simple molecule with significant potential as a pharmacological agent. For example, its use in the possible treatment of heart failure has received recent attention due to its unique therapeutic properties. Recent progress has been made on the elucidation of the mechanisms associated with its biological signaling. Importantly, the biochemical mechanisms described for HNO bioactivity are consistent with its unique and novel chemical properties/reactivity. To date, much of the biology of HNO can be associated with interactions and modification of important regulatory thiol proteins. Herein will be provided a description of HNO chemistry and how this chemistry translates to some of its reported biological effects.
authors.affiliation: Department of Chemistry, Johns Hopkins University, Baltimore, MD 21218, USA.
authors.forename: Christopher L
authors.initials: CL
authors.lastname: Bianco
authors.affiliation: Department of Chemistry, Johns Hopkins University, Baltimore, MD 21218, USA.
authors.forename: John P
authors.initials: JP
authors.lastname: Toscano
authors.affiliation: Department of Therapeutic Discovery, Amgen Inc., One Amgen Center Drive, Thousand Oaks, CA 91320, USA.
authors.forename: Michael D
authors.initials: MD
authors.lastname: Bartberger
authors.affiliation: Department of Chemistry, Sonoma State University, Rohnert Park, CA 94928, USA. Electronic address: jon.fukuto@sonoma.edu.
authors.forename: Jon M
authors.initials: JM
authors.lastname: Fukuto
mesh_terms: D000444:Aldehyde Dehydrogenase / Q000737:chemistry; D000818:Animals; D000975:Antioxidants / Q000737:chemistry; D006333:Heart Failure / Q000628:therapy; D006801:Humans; D009569:Nitric Oxide / Q000378:metabolism; D009589:Nitrogen Oxides / Q000737:chemistry*; D011485:Protein Binding; D051140:Selenoproteins / Q000737:chemistry; D015398:Signal Transduction; D013438:Sulfhydryl Compounds / Q000737:chemistry*
chemical_list: D000975:Antioxidants; D009589:Nitrogen Oxides; D051140:Selenoproteins; D013438:Sulfhydryl Compounds; D009569:Nitric Oxide; D000444:Aldehyde Dehydrogenase; C039900:nitroxyl
keywords: Azanone; Nitrogen oxides; Nitroxyl; Thiols