title: Antinociceptive Activity of Zanthoxylum piperitum DC. Essential Oil.
abstract: Zanthoxylum piperitum DC. (ZP) is a traditional medicinal plant used mainly in countries from Asia such as Japan. This study aimed to investigate the antinociceptive effect of ZP essential oil (ZPEO). The major component present in the essential oil was beta-phellandrene (29.39%). Its antinociceptive activity was tested through animal models (formalin-, capsaicin-, and glutamate-induced paw licking and hot plate). The anti-inflammatory effect was evaluated through the carrageenan-induced leukocyte migration into the subcutaneous air pouch (SAP), with measurement of cytokines. The results showed antinociceptive effect for ZPEO for the first phase of the formalin-induced licking, glutamate, and hot plate tests. However, ZPEO had no effect on reducing paw licking induced by capsaicin. Finally, ZPEO had no effect against inflammation induced by carrageenan.
authors.affiliation: Federal University of Rio de Janeiro, Institute of Biomedical Sciences, Avenida Carlos Chagas Filho 373, CCS, Laboratory J10, 21941-902 Rio de Janeiro, RJ, Brazil.
authors.forename: Graciela Rocha
authors.initials: GR
authors.lastname: Donald
authors.affiliation: Federal University of Rio de Janeiro, Institute of Biomedical Sciences, Avenida Carlos Chagas Filho 373, CCS, Laboratory J10, 21941-902 Rio de Janeiro, RJ, Brazil.
authors.forename: Patrícia Dias
authors.initials: PD
authors.lastname: Fernandes
authors.affiliation: School of Pharmacy and Pharmaceutical Sciences, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland.
authors.forename: Fabio
authors.identifier: 0000-0001-5531-1787
authors.initials: F
authors.lastname: Boylan