title: Depression in adult patients with biotin responsive basal ganglia disease.
abstract: Biotin responsive basal ganglia disease (BBGD), is a potentially treatable inherited metabolic disorder which clinically presents as sub-acute encephalopathy in children. Early diagnosis and treatment of this disorder results in good clinical recovery in childhood. However, there is no report in the literature on the long term outcome of these treated patients in adult life. We report two patients with BBGD who were metabolically stable on treatment and developed depression later in life. These cases highlight the association of depression with basal ganglia disorders and demonstrate that depression is the potential long term complication of BBGD.
authors.affiliation: Department of Medical Genetics, King Faisal Specialist Hospital and Research center.
authors.forename: Dalal K
authors.initials: DK
authors.lastname: Bubshait
authors.forename: Asif
authors.initials: A
authors.lastname: Rashid
authors.forename: Mohammed A
authors.initials: MA
authors.lastname: Al-Owain
authors.forename: Raashda A
authors.initials: RA
authors.lastname: Sulaiman
mesh_terms: D000328:Adult; D000928:Antidepressive Agents / Q000627:therapeutic use; D001480:Basal Ganglia Diseases / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000523:psychology*; D001710:Biotin / Q000627:therapeutic use; D002421:Caudate Nucleus / Q000000981:diagnostic imaging; D003865:Major Depressive Disorder / Q000188:drug therapy / Q000523:psychology*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D009336:Necrosis; D011699:Putamen / Q000000981:diagnostic imaging; D035781:Siblings; D013831:Thiamine / Q000627:therapeutic use; D014803:Vitamin B Complex / Q000627:therapeutic use
chemical_list: D000928:Antidepressive Agents; D014803:Vitamin B Complex; D001710:Biotin; D013831:Thiamine