title: Runx2 and microRNA regulation in bone and cartilage diseases.
abstract: The homeostasis of skeletal tissues requires tight regulation of a variety of signaling pathways, and the onset and progression of skeletal diseases are often caused by signaling abnormalities. MicroRNAs (miRNAs) are short noncoding RNA molecules that have emerged as a new dimension of gene regulation. MiRNAs have been shown to play an important role in the regulation of the differentiation of embryonic and hematopoietic stem cells. However, the role of specific miRNAs and their target genes has not been fully defined in the regulation of mesenchymal stem cells. Runx2 is a key transcription factor controlling MSC differentiation and bone and cartilage function. This article reviews work on Runx2 and miRNA regulation in bone and cartilage diseases.
authors.affiliation: Department of Biochemistry, Rush University Medical Center, Chicago, Illionois.|Department of Orthopaedics and Traumatology, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong, China.
authors.forename: Weiwei
authors.initials: W
authors.lastname: Zhao
authors.affiliation: Department of Biochemistry, Rush University Medical Center, Chicago, Illionois.
authors.forename: Shanxing
authors.initials: S
authors.lastname: Zhang
authors.affiliation: Key Lab of Hormone and Development (Ministry of Health), Metabolic Diseases Hospital and Tianjin Institute of Endocrinology, Tianjin Medical University, Tianjin, China.
authors.forename: Baoli
authors.initials: B
authors.lastname: Wang
authors.affiliation: Department of Biochemistry, Rush University Medical Center, Chicago, Illionois.
authors.forename: Jian
authors.initials: J
authors.lastname: Huang
authors.affiliation: Department of Orthopaedics and Traumatology, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong, China.
authors.forename: William W
authors.initials: WW
authors.lastname: Lu
authors.affiliation: Department of Biochemistry, Rush University Medical Center, Chicago, Illionois.
authors.forename: Di
authors.initials: D
authors.lastname: Chen
mesh_terms: D000818:Animals; D001847:Bone Diseases / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D002357:Cartilage Diseases / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D002454:Cell Differentiation / Q000502:physiology; D050659:Core Binding Factor Alpha 1 Subunit / Q000502:physiology*; D006801:Humans; D035683:MicroRNAs / Q000502:physiology*
chemical_list: D050659:Core Binding Factor Alpha 1 Subunit; D035683:MicroRNAs; C493709:RUNX2 protein, human
keywords: Runx2; bone; cartilage; microRNA