title: Macroscopic Neural Oscillation during Skilled Reaching Movements in Humans.
abstract: The neural mechanism of skilled movements, such as reaching, has been considered to differ from that of rhythmic movement such as locomotion. It is generally thought that skilled movements are consciously controlled by the brain, while rhythmic movements are usually controlled autonomously by the spinal cord and brain stem. However, several studies in recent decades have suggested that neural networks in the spinal cord may also be involved in the generation of skilled movements. Moreover, a recent study revealed that neural activities in the motor cortex exhibit rhythmic oscillations corresponding to movement frequency during reaching movements as rhythmic movements. However, whether the oscillations are generated in the spinal cord or the cortical circuit in the motor cortex causes the oscillations is unclear. If the spinal cord is involved in the skilled movements, then similar rhythmic oscillations with time delays should be found in macroscopic neural activity. We measured whole-brain MEG signals during reaching. The MEG signals were analyzed using a dynamical analysis method. We found that rhythmic oscillations with time delays occur in all subjects during reaching movements. The results suggest that the corticospinal system is involved in the generation and control of the skilled movements as rhythmic movements.
authors.affiliation: Interdisciplinary Program in Neuroscience, Seoul National University, Seoul 151-742, Republic of Korea.
authors.forename: Hong Gi
authors.identifier: 0000-0002-5323-413X
authors.initials: HG
authors.lastname: Yeom
authors.affiliation: Department of Brain and Cognitive Sciences, College of Natural Sciences, Seoul National University, Seoul 151-742, Republic of Korea.
authors.forename: June Sic
authors.identifier: 0000-0002-9659-4944
authors.initials: JS
authors.lastname: Kim
authors.affiliation: Interdisciplinary Program in Neuroscience, Seoul National University, Seoul 151-742, Republic of Korea; Department of Brain and Cognitive Sciences, College of Natural Sciences, Seoul National University, Seoul 151-742, Republic of Korea; Department of Neurosurgery, Seoul National University Hospital, Seoul 110-744, Republic of Korea.
authors.forename: Chun Kee
authors.initials: CK
authors.lastname: Chung
mesh_terms: D000328:Adult; D001921:Brain / Q000502:physiology*; D001931:Brain Mapping; D004569:Electroencephalography; D005260:Female; D006801:Humans; D016014:Linear Models; D015225:Magnetoencephalography; D008297:Male; D009068:Movement / Q000502:physiology*; D009434:Neural Pathways / Q000502:physiology*; D017711:Nonlinear Dynamics; D010507:Periodicity; D010775:Photic Stimulation; D025341:Principal Component Analysis; D011597:Psychomotor Performance / Q000502:physiology*; D013116:Spinal Cord / Q000502:physiology; D055815:Young Adult