title: [Expression and Significance of HOXA9 in Patients with Myelodysplastic Syndromes].
abstract: OBJECTIVE
  To investigate the expression pattern of HOXA9 in myelodysplastic syndrome (MDS) patients and its relation with clinical characteristics and treatment response.
  
  
  METHODS
  The mRNA and protein expression levels of HOXA9 in bone marrow cells from 33 cases of MDS, 12 cases of AML, 20 cases of ITP and 18 normal controls were detected by real-time guautitative PCR(RT-PCR) and flow cytometry, respectively.
  
  
  RESULTS
  The percentage of HOXA9(+)/CD34(+) and HOXA9(+)/CD34(+)CD38(-) in MDS patients were significantly higher than that in control group (P<0.05), and the mRNA and protein expression of HOXA9 in MDS patients had a similar trend. The percentages of HOXA9(+)/CD34(+) and HOXA9(+)/CD34(+)CD38(-) before decitabine treatment were (50.64±27.59)% and (55.67±28.57)% respectively, which were both higher than those in control group (P<0.05). After decitabine treatment, expression of HOXA9 significantly decreased (P<0.05).
  
  
  CONCLUSIONS
  HOXA9 is overexpressed in MDS patients and associated with several clinical characteristics. The detection of HOXA9 expression may have guide roles for diagnosis and treatment of MDS patients.
authors.affiliation: Department of Hematology, General Hospital of Tianjin Medical University, Tianjin 300052, China.
authors.forename: Xin-Yan
authors.initials: XY
authors.lastname: Xie
authors.affiliation: Department of Hematology, General Hospital of Tianjin Medical University, Tianjin 300052, China. E-mail:shaozonghong@sina.com.
authors.forename: Zong-Hong
authors.initials: ZH
authors.lastname: Shao
authors.affiliation: Department of Hematology, General Hospital of Tianjin Medical University, Tianjin 300052, China.
authors.forename: Rong
authors.initials: R
authors.lastname: Fu
authors.affiliation: Department of Hematology, General Hospital of Tianjin Medical University, Tianjin 300052, China.
authors.forename: Li-Juan
authors.initials: LJ
authors.lastname: Li
authors.affiliation: Department of Hematology, General Hospital of Tianjin Medical University, Tianjin 300052, China.
authors.forename: Hua-Quan
authors.initials: HQ
authors.lastname: Wang
authors.affiliation: Department of Hematology, General Hospital of Tianjin Medical University, Tianjin 300052, China.
authors.forename: Hui
authors.initials: H
authors.lastname: Liu
authors.affiliation: Department of Hematology, General Hospital of Tianjin Medical University, Tianjin 300052, China.
authors.forename: Yi-Hao
authors.initials: YH
authors.lastname: Wang
authors.affiliation: Department of Hematology, General Hospital of Tianjin Medical University, Tianjin 300052, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Zhang
authors.affiliation: Department of Hematology, General Hospital of Tianjin Medical University, Tianjin 300052, China.
authors.forename: Jing-Lian
authors.initials: JL
authors.lastname: Tao
mesh_terms: D001854:Bone Marrow Cells; D005434:Flow Cytometry; D018398:Homeodomain Proteins; D006801:Humans; D009190:Myelodysplastic Syndromes
chemical_list: D018398:Homeodomain Proteins; C097899:homeobox protein HOXA9