title: Neonatal Encephalopathy: Update on Therapeutic Hypothermia and Other Novel Therapeutics.
abstract: Neonatal encephalopathy (NE) is a major cause of neonatal mortality and morbidity. Therapeutic hypothermia (TH) is standard treatment for newborns at 36 weeks of gestation or greater with intrapartum hypoxia-related NE. Term and late preterm infants with moderate to severe encephalopathy show improved survival and neurodevelopmental outcomes at 18 months of age after TH. TH can increase survival without increasing major disability, rates of an IQ less than 70, or cerebral palsy. Neonates with severe NE remain at risk of death or severe neurodevelopmental impairment. This review discusses the evidence supporting TH for term or near term neonates with NE.
authors.affiliation: Division of Neonatology, Department of Pediatrics, University of Washington, Box 356320, Seattle, WA 98195-6320, USA. Electronic address: mcadams@uw.edu.
authors.forename: Ryan M
authors.initials: RM
authors.lastname: McAdams
authors.affiliation: Division of Neonatology, Department of Pediatrics, University of Washington, Box 356320, Seattle, WA 98195-6320, USA.
authors.forename: Sandra E
authors.initials: SE
authors.lastname: Juul
mesh_terms: D018685:Anesthetics, Inhalation / Q000627:therapeutic use; D001710:Biotin / Q000031:analogs & derivatives / Q000627:therapeutic use; D002492:Central Nervous System Depressants / Q000627:therapeutic use; D002547:Cerebral Palsy; D003250:Constriction; D004921:Erythropoietin / Q000627:therapeutic use; D006801:Humans; D007036:Hypothermia, Induced; D020925:Hypoxia-Ischemia, Brain / Q000628:therapy*; D007231:Infant, Newborn; D008607:Intellectual Disability; D008550:Melatonin / Q000627:therapeutic use; D033581:Stem Cell Transplantation; D015996:Survival Rate; D014470:Umbilical Cord; D014978:Xenon / Q000627:therapeutic use
chemical_list: D018685:Anesthetics, Inhalation; D002492:Central Nervous System Depressants; D004921:Erythropoietin; D014978:Xenon; D001710:Biotin; C028072:2-iminobiotin; D008550:Melatonin
keywords: Dexmedetomidine; Erythropoietin; Melatonin; N-acetylcysteine; Neurodevelopment; Stem cells; Umbilical cord milking; Xenon