title: Serum levels of adiponectin, CCL3/MIP-1α, and CCL5/RANTES discriminate migraine from tension-type headache patients.
abstract: OBJECTIVE
  Inflammatory molecules and neurotrophic factors are implicated in pain modulation; however, their role in primary headaches is not yet clear. The aim of this study was to compare the levels of serum biomarkers in migraine and tension-type headache.
  
  
  METHODS
  This was a cross-sectional study. We measured serum levels of adiponectin, chemokines, and neurotrophic factors in patients with migraine and tension-type headache. Depression and anxiety symptoms, headache impact and frequency, and allodynia were recorded.
  
  
  RESULTS
  We included sixty-eight patients with migraine and forty-eight with tension-type headache. Cutaneous allodynia (p = 0.035), CCL3/MIP-1α (p = 0.041), CCL5/RANTES (p = 0.013), and ADP (p = 0.017) were significantly higher in migraine than in tension-type headache. The differences occurred independently of anxiety and depressive symptoms, frequency and impact of headache, and the presence of pain.
  
  
  CONCLUSIONS
  This study showed higher CCL3/MIP-1α, CCL5/RANTES, and ADP levels in migraine in comparison with tension-type headache. Our findings suggest distinctive roles of these molecules in the pathophysiology of these primary headaches.
authors.affiliation: Universidade Federal de Minas Gerais, Programa de Neurociências, Belo Horizonte MG, Brasil;|Senne Liquor Diagnóstico, São Paulo SP, Brasil;
authors.forename: Renan B
authors.initials: RB
authors.lastname: Domingues
authors.affiliation: Universidade Federal de Minas Gerais, Programa de Neurociências, Belo Horizonte MG, Brasil;
authors.forename: Halina
authors.initials: H
authors.lastname: Duarte
authors.affiliation: Senne Liquor Diagnóstico, São Paulo SP, Brasil;|Universidade Federal de Minas Gerais, Faculdade de Medicina, Laboratório Interdisciplinar de Investigação Médica, Belo Horizonte MG, Brasil;
authors.forename: Carlos
authors.initials: C
authors.lastname: Senne
authors.affiliation: Senne Liquor Diagnóstico, São Paulo SP, Brasil;|Universidade Federal de Minas Gerais, Faculdade de Medicina, Laboratório Interdisciplinar de Investigação Médica, Belo Horizonte MG, Brasil;
authors.forename: Gustavo
authors.initials: G
authors.lastname: Bruniera
authors.affiliation: Senne Liquor Diagnóstico, São Paulo SP, Brasil;|Universidade Federal de Minas Gerais, Faculdade de Medicina, Laboratório Interdisciplinar de Investigação Médica, Belo Horizonte MG, Brasil;
authors.forename: Fernando
authors.initials: F
authors.lastname: Brunale
authors.affiliation: Hospital Israelita Albert Einstein, Laboratório de Patologia Clínica, São Paulo SP, Brasil.
authors.forename: Natália P
authors.initials: NP
authors.lastname: Rocha
authors.affiliation: Universidade Federal de Minas Gerais, Programa de Neurociências, Belo Horizonte MG, Brasil;|Hospital Israelita Albert Einstein, Laboratório de Patologia Clínica, São Paulo SP, Brasil.
authors.forename: Antonio L
authors.initials: AL
authors.lastname: Teixeira
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D019208:Brain-Derived Neurotrophic Factor / Q000097:blood*; D054405:Chemokine CCL3 / Q000097:blood*; D018946:Chemokine CCL5 / Q000097:blood*; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008881:Migraine Disorders / Q000097:blood / Q000175:diagnosis*; D018781:Tension-Type Headache / Q000097:blood / Q000175:diagnosis*; D055815:Young Adult
chemical_list: D015415:Biomarkers; D019208:Brain-Derived Neurotrophic Factor; D054405:Chemokine CCL3; D018946:Chemokine CCL5; C108335:RANTES, Met-