title: Repositioning of Endonuclear Receptors Binders as Potential Antibacterial and Antifungal Agents. Eptyloxìm: A Potential and Novel Gyrase B and Cytochrome Cyp51 Inhibitor.
abstract: A novel class of antibacterial and antifungal agents is here identified by means of dockings and virtual screening techniques. Biological data proved the initial effort, formulated on the structure similarity of nuclear receptors binders with known quinolones or thiazole derivatives, to reposition PPARs agonists as likely bacterial type II topoisomerases inhibitors.
authors.affiliation: Department of Pharmacy - Drug Sciences, University of Bari "Aldo Moro", Via E. Orabona, 4, I-70125, Bari, Italy. antonio.carrieri@uniba.it.
authors.forename: Antonio
authors.initials: A
authors.lastname: Carrieri
authors.affiliation: Department of Pharmacy - Drug Sciences, University of Bari "Aldo Moro", Via E. Orabona, 4, I-70125, Bari, Italy.
authors.forename: Maria
authors.initials: M
authors.lastname: L'Abbate
authors.affiliation: Department of Pharmacy - Drug Sciences, University of Bari "Aldo Moro", Via E. Orabona, 4, I-70125, Bari, Italy.
authors.forename: Mariangela
authors.initials: M
authors.lastname: Di Chicco
authors.affiliation: Department of Pharmacy - Drug Sciences, University of Bari "Aldo Moro", Via E. Orabona, 4, I-70125, Bari, Italy.
authors.forename: Antonio
authors.initials: A
authors.lastname: Rosato
authors.affiliation: Department of Pharmacy - Drug Sciences, University of Bari "Aldo Moro", Via E. Orabona, 4, I-70125, Bari, Italy.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Carbonara
authors.affiliation: Department of Pharmacy - Drug Sciences, University of Bari "Aldo Moro", Via E. Orabona, 4, I-70125, Bari, Italy.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Fracchiolla
mesh_terms: D058888:14-alpha Demethylase Inhibitors / Q000737:chemistry* / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology; D000935:Antifungal Agents / Q000737:chemistry* / Q000494:pharmacology; D027081:DNA Gyrase / Q000378:metabolism*; D004250:DNA Topoisomerases, Type II / Q000378:metabolism; D047492:Peroxisome Proliferator-Activated Receptors / Q000819:agonists; D015363:Quinolones / Q000737:chemistry / Q000494:pharmacology; D058886:Sterol 14-Demethylase / Q000378:metabolism; D013844:Thiazoles / Q000737:chemistry / Q000494:pharmacology; D059005:Topoisomerase II Inhibitors / Q000737:chemistry* / Q000494:pharmacology
chemical_list: D058888:14-alpha Demethylase Inhibitors; D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D047492:Peroxisome Proliferator-Activated Receptors; D015363:Quinolones; D013844:Thiazoles; D059005:Topoisomerase II Inhibitors; D058886:Sterol 14-Demethylase; D027081:DNA Gyrase; D004250:DNA Topoisomerases, Type II
keywords: Docking; Drug repositioning; Topisomerase inhibitors; Virtual screening