title: In Vitro Bactericidal Activity of Trimethoprim-Sulfamethoxazole Alone and in Combination with Colistin against Carbapenem-Resistant Acinetobacter baumannii Clinical Isolates.
abstract: Trimethoprim-sulfamethoxazole alone and combined with colistin was tested in vitro against six carbapenem-resistant Acinetobacter baumannii (CRAB) clinical strains. After 24 h, at achievable serum concentrations, trimethoprim-sulfamethoxazole effectively killed all strains, while colistin killed only one strain. Trimethoprim-sulfamethoxazole plus colistin rapidly killed all strains after 6 h and for up to 24 h. Trimethoprim-sulfamethoxazole, one of the few remaining antimicrobials that still has a degree of activity, particularly combined with colistin, might represent an effective therapy for severe CRAB infections.
authors.affiliation: Department of Microbiology, Evaggelismos General Hospital, Athens, Greece.
authors.forename: Martha
authors.initials: M
authors.lastname: Nepka
authors.affiliation: Department of Microbiology, Evaggelismos General Hospital, Athens, Greece.
authors.forename: Efstathia
authors.initials: E
authors.lastname: Perivolioti
authors.affiliation: Department of Microbiology, Evaggelismos General Hospital, Athens, Greece.
authors.forename: Eleni
authors.initials: E
authors.lastname: Kraniotaki
authors.affiliation: Department of Microbiology, Medical School, National & Kapodistrian University of Athens, Athens, Greece.
authors.forename: Lida
authors.initials: L
authors.lastname: Politi
authors.affiliation: Department of Microbiology, Medical School, National & Kapodistrian University of Athens, Athens, Greece.
authors.forename: Athanasios
authors.initials: A
authors.lastname: Tsakris
authors.affiliation: Department of Microbiology, Medical School, National & Kapodistrian University of Athens, Athens, Greece spournaras@med.uoa.gr.
authors.forename: Spyros
authors.initials: S
authors.lastname: Pournaras
mesh_terms: D000151:Acinetobacter Infections / Q000188:drug therapy / Q000382:microbiology; D040981:Acinetobacter baumannii / Q000187:drug effects* / Q000235:genetics; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D015780:Carbapenems / Q000494:pharmacology*; D003091:Colistin / Q000494:pharmacology*; D024901:Drug Resistance, Multiple, Bacterial / Q000187:drug effects; D004357:Drug Synergism; D006801:Humans; D008826:Microbial Sensitivity Tests; D015662:Trimethoprim, Sulfamethoxazole Drug Combination / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D015780:Carbapenems; D015662:Trimethoprim, Sulfamethoxazole Drug Combination; D003091:Colistin