title: Amine-Catalyzed Phospha-Michael Reaction of α,β-Unsaturated Aldehydes and Ketones with Multifunctional N-Heterocyclic Phosphine-Thioureas as Phosphonylation Reagent.
abstract: An efficient amine-catalyzed phospha-Michael addition reaction of α,β-unsaturated aldehydes/ketones with N-heterocyclic phosphines for the synthesis of γ-ketodiazaphosphonates has been developed. With freedom from nucleophile additives, this mild process affords a range of structurally diverse γ-ketodiazaphosphonates in moderate to excellent yields. Importantly, various α,β-unsaturated ketones were also tolerated in this process and gave moderate yields.
authors.affiliation: Department of Chemistry and Biochemistry, University of Nevada Las Vegas , 4505 South Maryland Parkway, Las Vegas, Nevada 89154-4003, United States.|Department of Applied Chemistry, College of Chemistry and Molecular Engineering, Nanjing Tech University , No. 30 Puzhu Road (S), Nanjing 211816, People's Republic of China.
authors.forename: Hai
authors.initials: H
authors.lastname: Huang
authors.affiliation: Department of Chemistry and Biochemistry, University of Nevada Las Vegas , 4505 South Maryland Parkway, Las Vegas, Nevada 89154-4003, United States.
authors.forename: Jun Yong
authors.initials: JY
authors.lastname: Kang