title: The Development of Phosphine-Free "Tethered" Ruthenium(II) Catalysts for the Asymmetric Reduction of Ketones and Imines.
abstract: In this account, we describe the design, synthesis and applications of tethered versions of the Ru(II)/N-tosyl-1,2-diphenylethylene-1,2-diamine (TsDPEN) class of catalyst that are commonly used for asymmetric transfer hydrogenation and asymmetric hydrogenation of ketones and imines. The review covers key aspects of the reaction mechanisms and examples of applications, including industrial applications to pharmaceutically important target molecules. In addition, closely related catalysts based on Rh(III) and Ir(III) are also described.
authors.affiliation: Johnson Matthey, 28 Cambridge Science Park, Cambridge, CB4 0FP (UK).
authors.forename: Hans
authors.initials: H
authors.lastname: G Nedden
authors.affiliation: Johnson Matthey, 28 Cambridge Science Park, Cambridge, CB4 0FP (UK).
authors.forename: Antonio
authors.initials: A
authors.lastname: Zanotti-Gerosa
authors.affiliation: The Department of Chemistry, The University of Warwick, Coventry, CV4 7AL, UK.
authors.forename: Martin
authors.initials: M
authors.lastname: Wills
keywords: asymmetric catalysis; hydrogenation; reaction mechanisms; supported catalysts; tethered catalyst, transition metals