title: Total synthesis based on the originally claimed structure of mucosin.
abstract: The first total synthesis aimed at the naturally occurring eicosanoid bicycle mucosin is reported. A practical route has been devised allowing the issues relating to the previous assignment of stereochemistry to be examined. X-ray crystallography was performed on a late stage intermediate to pinpoint the topological relationship displayed by the featured bicyclo[4.3.0]non-3-ene scaffold.
authors.affiliation: Department of Chemistry, Norwegian University of Life Sciences, PO box 5003, 1432 Ås, Norway. yngve.stenstrom@nmbu.no jens.mj.nolsoe@nmbu.no.
authors.forename: Harrison C
authors.initials: HC
authors.lastname: Gallantree-Smith
authors.forename: Simen G
authors.initials: SG
authors.lastname: Antonsen
authors.forename: Carl H
authors.initials: CH
authors.lastname: Görbitz
authors.forename: Trond V
authors.initials: TV
authors.lastname: Hansen
authors.forename: Jens M J
authors.initials: JM
authors.lastname: Nolsøe
authors.forename: Yngve H
authors.initials: YH
authors.lastname: Stenstrøm
mesh_terms: D019086:Bridged Bicyclo Compounds, Heterocyclic / Q000138:chemical synthesis* / Q000737:chemistry; D018360:Crystallography, X-Ray; D008958:Models, Molecular; D015394:Molecular Structure
chemical_list: D019086:Bridged Bicyclo Compounds, Heterocyclic; C573270:mucosin