title: Neuroimaging and Other Neurodiagnostic Tests in Neonatal Encephalopathy.
abstract: Hypoxic-ischemic encephalopathy is associated with a high risk of morbidity and mortality in the neonatal period. Long-term neurodevelopmental disability is also frequent in survivors. Conventional MRI defines typical patterns of injury that reflect specific pathophysiologic mechanisms. Advanced magnetic resonance techniques now provide unique perspectives on neonatal brain metabolism, microstructure, and connectivity. The application of these imaging techniques has revealed that brain injury commonly occurs at or near the time of birth and evolves over the first weeks of life. Amplitude-integrated electroencephalogram and near-infrared spectroscopy are increasingly used as bedside tools in neonatal intensive care units to monitor brain function.
authors.affiliation: Division of Neonatology, Cincinnati Children's Hospital Medical Center, Perinatal Institute, ML 7009, Cincinnati, OH 45229, USA. Electronic address: stephanie.merhar@cchmc.org.
authors.forename: Stephanie L
authors.initials: SL
authors.lastname: Merhar
authors.affiliation: Division of Neurology (Pediatrics), The Hospital for Sick Children, University of Toronto and Neuroscience & Mental Health Research Institute, 555 University Avenue, Room 6536B, Hill Wing, Toronto, Ontario M5G 1X8, Canada.
authors.forename: Vann
authors.initials: V
authors.lastname: Chau
mesh_terms: D001238:Asphyxia Neonatorum / Q000150:complications / Q000000981:diagnostic imaging*; D001921:Brain / Q000000981:diagnostic imaging*; D004569:Electroencephalography; D006801:Humans; D007036:Hypothermia, Induced; D020925:Hypoxia-Ischemia, Brain / Q000000981:diagnostic imaging* / Q000209:etiology / Q000628:therapy; D007231:Infant, Newborn; D007363:Intensive Care Units, Neonatal; D008279:Magnetic Resonance Imaging; D009682:Magnetic Resonance Spectroscopy; D059906:Neuroimaging; D019265:Spectroscopy, Near-Infrared
keywords: Amplitude integrated EEG; Birth asphyxia; Hypoxic-ischemic encephalopathy; MR spectroscopy; MRI; Near-infrared spectroscopy