title: Diagnostic Utility of Acoustic Structure Quantification for Evaluation of Radiation Sialadenitis after Radioactive Iodine Therapy.
abstract: Acoustic structure quantification (ASQ) software was used to analyze statistical information on acquired echo signals, to determine the ability of ASQ to distinguish normal salivary glands of asymptomatic patients from glands of patients with radiation sialadenitis (RS) after radioactive iodine therapy. The ASQ values of 192 salivary glands were compared by multinomial logistic regression analysis, and receiver operating characteristic curves were constructed. Between-observer agreement was assessed by calculating the intra-class correlation coefficient. The mean ASQ values of patients with chronic RS or asymptomatic patients who had undergone radioactive iodine therapy were greater than those of patients with normal glands (p < 0.001). The ratio was associated with the highest odds ratio in patients with chronic RS compared with normal patients. Diagnostic performance was moderate; the intra-class correlation coefficient between observers was very good. ASQ can objectively differentiate RS-affected tissue from normal salivary tissue and is thus valuable for clinically diagnosing RS after radioactive iodine therapy.
authors.affiliation: Department of Radiology, Soonchunhyang University Bucheon Hospital, Bucheon, Republic of Korea.
authors.forename: Sun Hye
authors.initials: SH
authors.lastname: Jeong
authors.affiliation: Department of Radiology, Soonchunhyang University Bucheon Hospital, Bucheon, Republic of Korea. Electronic address: hshong@schmc.ac.kr.
authors.forename: Hyun Sook
authors.initials: HS
authors.lastname: Hong
authors.affiliation: Department of Radiology, Soonchunhyang University Bucheon Hospital, Bucheon, Republic of Korea.
authors.forename: Eun Hye
authors.initials: EH
authors.lastname: Lee
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D007457:Iodine Radioisotopes / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D015588:Observer Variation; D011446:Prospective Studies; D011832:Radiation Injuries / Q000000981:diagnostic imaging*; D012469:Salivary Glands / Q000000981:diagnostic imaging / Q000528:radiation effects; D012793:Sialadenitis / Q000000981:diagnostic imaging*; D013964:Thyroid Neoplasms / Q000532:radiotherapy*; D014463:Ultrasonography / Q000379:methods*; D055815:Young Adult
chemical_list: D007457:Iodine Radioisotopes
keywords: Acoustic structure quantification; Radioactive iodine; Salivary gland; Sialadenitis; Thyroid cancer; Ultrasonography