title: Brain Volume and Doppler Velocimetry in Growth-Restricted, Small-for-Gestational-Age, and Appropriate-for-Gestational-Age Fetuses.
abstract: ObjectiveThis study aims to detect possible differences in fetal brain volumes between growth-restricted fetuses (FGR), small-for-gestational-age (SGA) fetuses with normal Doppler indices, and appropriate-for-gestational-age fetuses (AGA).Study DesignThree-dimensional measurements of fetal brain volume and umbilical artery and middle cerebral artery (MCA) pulsatility index (PI) and resistance index (RI) were made in 80 AGA fetuses, 68 SGA fetuses with normal Doppler indices, and 68 FGR with brain-sparing effect between 32 and 36 weeks of gestation.ResultsMCA-PI and MCA-RI were significantly lower in FGR group compared with the other two groups (p< 0.001). Brain volume was significantly lower in SGA and FGR groups compared with AGA group (p< 0.001).ConclusionBrain volume is significantly lower in SGA and FGR groups compared with AGA group.
authors.affiliation: Department of Obstetrics and Gynecology, Faculty of Medicine, Cairo University, Cairo, Egypt.
authors.forename: Hala A E Wahab Abdel
authors.initials: HA
authors.lastname: Latif
authors.affiliation: Department of Obstetrics and Gynecology, Faculty of Medicine, Cairo University, Cairo, Egypt.
authors.forename: Hassan Mostafa
authors.initials: HM
authors.lastname: Gaafar
authors.affiliation: Department of Obstetrics and Gynecology, Faculty of Medicine, Cairo University, Cairo, Egypt.
authors.forename: Ghada Abdel Fattah Abdel
authors.initials: GA
authors.lastname: Moety
authors.affiliation: Department of Obstetrics and Gynecology, Faculty of Medicine, Cairo University, Cairo, Egypt.
authors.forename: Doaa Salah Eldin
authors.initials: DS
authors.lastname: Mahmoud
authors.affiliation: Department of Pediatrics, Faculty of Medicine, Cairo University, Cairo, Egypt.
authors.forename: Nihal Mohamed
authors.initials: NM
authors.lastname: El Rifai
mesh_terms: D000328:Adult; D001921:Brain / Q000098:blood supply* / Q000000981:diagnostic imaging / Q000254:growth & development*; D002560:Cerebrovascular Circulation; D005260:Female; D047109:Fetal Development; D005317:Fetal Growth Retardation / Q000503:physiopathology*; D005865:Gestational Age; D006801:Humans; D021621:Imaging, Three-Dimensional; D020768:Middle Cerebral Artery / Q000000981:diagnostic imaging / Q000503:physiopathology; D009929:Organ Size; D011247:Pregnancy; D011673:Pulsatile Flow; D018608:Ultrasonography, Doppler; D016216:Ultrasonography, Prenatal; D014469:Umbilical Arteries / Q000000981:diagnostic imaging / Q000503:physiopathology; D014655:Vascular Resistance; D055815:Young Adult