title: N-Heteroarylation of Optically Pure α-Amino Esters using the Pd-PEPPSI-IPentCl-o-picoline Pre-Catalyst.
abstract: A robust, mild, and efficient method for the Pd-catalyzed N-heteroarylation of optically pure α-amino esters was developed. Dichloro[1,3-bis(2,6-di-3-pentylphenyl)imidazol-2-ylidene](o-picoline)palladium(II) (Pd-PEPPSI-IPentCl-o-picoline; PEPPSI=pyridine enhanced pre-catalyst preparation, stabilization, and initiation) was shown to effectively couple a variety of amino acids as the tert-butyl ester with heteroaryl chlorides in high yields and with excellent stereoretention of the acidic proton adjacent to the ester. Control experiments revealed that racemization is base-mediated, with no evidence of Pd-mediated β-hydride elimination when using Pd-PEPPSI-IPentCl, and that racemization occurs only after the product is formed, that is, the non-arylated starting amino ester does not deprotonate under our reaction conditions. Studies also revealed that increasing the steric bulk of the ester moiety on the amino acid (e.g., ethyl to tert-butyl) drastically slows racemization of the product.
authors.affiliation: Department of Chemistry, York University, 4700 Keele Street, Toronto, Ontario, M3J 1P3, Canada.
authors.forename: Sepideh
authors.initials: S
authors.lastname: Sharif
authors.affiliation: Lilly Research Laboratories, A Division of Eli Lilly and Company, Indianapolis, IN, 46285, USA.
authors.forename: David
authors.initials: D
authors.lastname: Mitchell
authors.affiliation: Lilly Research Laboratories, A Division of Eli Lilly and Company, Indianapolis, IN, 46285, USA.
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Rodriguez
authors.affiliation: Department of Chemistry, York University, 4700 Keele Street, Toronto, Ontario, M3J 1P3, Canada.
authors.forename: Jennifer L
authors.initials: JL
authors.lastname: Farmer
authors.affiliation: Department of Chemistry, York University, 4700 Keele Street, Toronto, Ontario, M3J 1P3, Canada. organ@uottawa.ca.|Centre for Catalysis Research and Innovation (CCRI), Department of Chemistry, University of Ottawa, Ottawa, Ontario, Canada. organ@uottawa.ca.
authors.forename: Michael G
authors.identifier: http://orcid.org/0000-0002-4625-5696
authors.initials: MG
authors.lastname: Organ
keywords: N-heteroaryl α-amino esters; PEPPSI; amination; cross-coupling; palladium