title: Pharmacogenetics of ribavirin-induced anemia in hepatitis C.
abstract: Pharmacogenetics assesses inherited genetic differences in drug metabolic pathways and its role in medicine is growing. Ribavirin (RBV) and peginterferon were the standard of care therapy in hepatitis C virus infection during 15 years, with the addition of first-generation protease inhibitors at the beginning of 2010s. New direct-acting agents are the new standard of care, but RBV remains important in some scenarios. The main adverse effect of RBV is anemia, which requires dose reduction and even stopping treatment in some patients. Pharmacogenetics has identified ITPA and SLC28/29 genes to be closely related to RBV-induced anemia. The routine evaluation of these genes could help to identify those patients at risk of developing anemia during the hepatitis C virus treatment.
authors.affiliation: Inter-Centre Unit of Digestive Diseases, Virgen del Rocío - Virgen Macarena University Hospitals, University of Sevilla, Sevilla, Spain.|Instituto de Biomedicina de Sevilla, Avenida Manuel Siurot, s/n, 41013 Sevilla, Spain.
authors.forename: Javier
authors.initials: J
authors.lastname: Ampuero
authors.affiliation: Inter-Centre Unit of Digestive Diseases, Virgen del Rocío - Virgen Macarena University Hospitals, University of Sevilla, Sevilla, Spain.|Instituto de Biomedicina de Sevilla, Avenida Manuel Siurot, s/n, 41013 Sevilla, Spain.
authors.forename: Manuel
authors.initials: M
authors.lastname: Romero-Gómez
mesh_terms: D000740:Anemia / Q000139:chemically induced*; D000998:Antiviral Agents / Q000009:adverse effects*; D033721:Equilibrative Nucleoside Transporter 1 / Q000235:genetics; D006526:Hepatitis C / Q000188:drug therapy*; D006801:Humans; D026901:Membrane Transport Proteins / Q000235:genetics; D010597:Pharmacogenetics; D012254:Ribavirin / Q000009:adverse effects*
chemical_list: D000998:Antiviral Agents; D033721:Equilibrative Nucleoside Transporter 1; D026901:Membrane Transport Proteins; C438649:SLC29A1 protein, human; C065171:cif nucleoside transporter; D012254:Ribavirin
keywords: ITPA; SLC28; anemia; hepatitis C; pharmacogenetics; ribavirin