title: Graphene oxide-enhanced sol-gel transition sensitivity and drug release performance of an amphiphilic copolymer-based nanocomposite.
abstract: We report the fabrication of a highly sensitive amphiphilic copolymer-based nanocomposite incorporating with graphene oxide (GO), which exhibited a low-intensity UV light-triggered sol-gel transition. Non-cytotoxicity was observed for the composite gels after the GO incorporation. Of particular interest were the microchannels that were formed spontaneously within the GO-incorporated UV-gel, which expedited sustained drug release. Therefore, the present highly UV-sensitive, non-cytotoxic amphiphilic copolymer-based composites is expected to provide enhanced photothermal therapy and chemotherapy by means of GO's unique photothermal properties, as well as through efficient passive targeting resulting from the sol-gel transition characteristic of the copolymer-based system with improved sensitivity, which thus promises the enhanced treatment of patients with cancer and other diseases.
authors.affiliation: Foshan University, Guangdong, 528000, China.
authors.forename: Huawen
authors.initials: H
authors.lastname: Hu
authors.affiliation: The Hong Kong Polytechnic University, Hong Kong SAR, 999077, China.
authors.forename: Xiaowen
authors.initials: X
authors.lastname: Wang
authors.affiliation: The Hong Kong Polytechnic University, Hong Kong SAR, 999077, China.
authors.forename: Ka I
authors.initials: KI
authors.lastname: Lee
authors.affiliation: The Hong Kong Polytechnic University, Hong Kong SAR, 999077, China.
authors.forename: Kaikai
authors.initials: K
authors.lastname: Ma
authors.affiliation: The Hong Kong Polytechnic University, Hong Kong SAR, 999077, China.
authors.forename: Hong
authors.initials: H
authors.lastname: Hu
authors.affiliation: The Hong Kong Polytechnic University, Hong Kong SAR, 999077, China.
authors.forename: John H
authors.initials: JH
authors.lastname: Xin
mesh_terms: D002478:Cells, Cultured; D003692:Delayed-Action Preparations / Q000737:chemistry / Q000494:pharmacology; D006108:Graphite / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D006979:Hyperthermia, Induced / Q000379:methods; D015603:Keratinocytes / Q000166:cytology / Q000378:metabolism*; D008422:Materials Testing; D053761:Nanocomposites / Q000737:chemistry*; D044367:Phase Transition; D010789:Phototherapy / Q000379:methods; D014466:Ultraviolet Rays
chemical_list: D003692:Delayed-Action Preparations; D006108:Graphite