title: Muscle Oxygen Dynamics During Cycling Exercise in Angina Pectoris Patients.
abstract: Muscle O2 dynamics during ramp cycling exercise were compared between angina pectoris patients (AP; n = 7, age: 73 ± 6 years) after coronary artery bypass grafting and age-, height-, and body weight-matched elderly control subjects (CON; n = 7, age: 74 ± 8 years). Muscle O2 saturation (SmO2) and relative change in deoxygenated (∆deoxy-Hb) and total hemoglobin concentration (∆total-Hb) were measured continuously during exercise in the vastus lateralis (VL) by near infrared spatial resolved spectroscopy. Pulmonary O2 uptake (VO2) was also monitored throughout exercise to determine peak VO2. In AP, SmO2 was significantly higher, and ∆deoxy-Hb was significantly lower during exercise, compared to CON. In all subjects, ∆SmO2 (values at peak exercise minus values at resting) was negatively correlated to peak VO2 (r = -0.52, p < 0.05), and ∆deoxy-Hb at peak exercise tended to be negatively associated with peak VO2 (r = 0.48, p = 0.07). Blunted skeletal muscle deoxygenation response was observed in AP patients, which may be related to lower aerobic capacity in AP patients.
authors.affiliation: Faculty of Sport Sciences, Waseda University, Tokorozawa, Saitama, Japan. stakagi@aoni.waseda.jp.|Department of Sports Medicine for Health Promotion, Tokyo Medical University, Shinjuku, Tokyo, Japan. stakagi@aoni.waseda.jp.
authors.forename: Shun
authors.initials: S
authors.lastname: Takagi
authors.affiliation: Department of Sports Medicine for Health Promotion, Tokyo Medical University, Shinjuku, Tokyo, Japan.
authors.forename: Norio
authors.initials: N
authors.lastname: Murase
authors.affiliation: Department of Sports Medicine for Health Promotion, Tokyo Medical University, Shinjuku, Tokyo, Japan.
authors.forename: Ryotaro
authors.initials: R
authors.lastname: Kime
authors.affiliation: Department of Electrical and Electronic Engineering, Shizuoka University, Hamamatsu, Shizuoka, Japan.
authors.forename: Masatsugu
authors.initials: M
authors.lastname: Niwayama
authors.affiliation: Department of Sports Medicine for Health Promotion, Tokyo Medical University, Shinjuku, Tokyo, Japan.
authors.forename: Takuya
authors.initials: T
authors.lastname: Osada
authors.affiliation: Department of Sports Medicine for Health Promotion, Tokyo Medical University, Shinjuku, Tokyo, Japan.
authors.forename: Toshihito
authors.initials: T
authors.lastname: Katsumura
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000787:Angina Pectoris / Q000378:metabolism* / Q000503:physiopathology; D001642:Bicycling; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D005080:Exercise Test; D017079:Exercise Tolerance; D005260:Female; D006454:Hemoglobins / Q000378:metabolism; D006801:Humans; D008297:Male; D009119:Muscle Contraction; D010092:Oximetry / Q000379:methods; D010100:Oxygen / Q000097:blood*; D010101:Oxygen Consumption; D010108:Oxyhemoglobins / Q000378:metabolism; D052097:Quadriceps Muscle / Q000378:metabolism* / Q000503:physiopathology; D019265:Spectroscopy, Near-Infrared; D013997:Time Factors
chemical_list: D015415:Biomarkers; D006454:Hemoglobins; D010108:Oxyhemoglobins; C100003:deoxyhemoglobin; D010100:Oxygen
keywords: Aerobic capacity; Blood volume; Ischemic heart disease; Muscle oxygen saturation; Near infrared spectroscopy