title: Impact of Obstructive Sleep Apnea on Neurocognitive Function and Impact of Continuous Positive Air Pressure.
abstract: There is evidence that obstructive sleep apnea (OSA) can negatively impact attention, memory, learning, executive function, and overall intellectual function in adults and children. Imaging techniques, including MRI, MR diffusion tensor imaging, MR spectroscopy, and fMRI, have provided additional insight into the anatomic and functional underpinnings of OSA-related cognitive impairment. Both animal and human studies have looked to elucidate the separate effects of oxygen desaturation and sleep fragmentation on independent aspects of cognition. Data from animal models point to neuro-inflammation and oxidative stress as driving factors of cognitive impairment.
authors.affiliation: Carle Neuroscience Institute, Carle Foundation Hospital, College of Medicine, University of Illinois at Urbana-Champaign, 602 West University Avenue, Urbana, IL 61801, USA. Electronic address: charles.davies@carle.com.
authors.forename: Charles R
authors.initials: CR
authors.lastname: Davies
authors.affiliation: Division of Pulmonary, Critical Care, Sleep and Allergy, Department of Medicine, 985990 Nebraska Medical Center, Omaha, NE 68159-5990, USA.
authors.forename: John J
authors.initials: JJ
authors.lastname: Harrington
mesh_terms: D060825:Cognitive Dysfunction / Q000209:etiology / Q000628:therapy*; D045422:Continuous Positive Airway Pressure / Q000379:methods*; D006801:Humans; D020181:Sleep Apnea, Obstructive / Q000150:complications / Q000628:therapy*
keywords: Cognition; Continuous positive airway pressure (CPAP); Neurocognitive function; Obstructive sleep apnea