title: Highly efficient anion transport mediated by 1,3-bis(benzimidazol-2-yl)benzene derivatives bearing electron-withdrawing substituents.
abstract: 1,3-Bis(benzimidazol-2-yl)benzene exhibits potent anionophoric activity through a process of anion exchange with a minor level of proton/anion symport. Modification of 1,3-bis(benzimidazol-2-yl)benzene with strong electron-withdrawing substituents, such as trifluoromethyl and nitro groups, leads to up to 789-fold increase in the activity. The benzimidazolyl-NH fragments, the relative position and the number of the benzimidazolyl groups on the central phenyl scaffold play an essential role in the transport.
authors.affiliation: Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, P. R. China. whchen@smu.edu.cn.
authors.forename: Chen-Chen
authors.initials: CC
authors.lastname: Peng
authors.forename: Meng-Jia
authors.initials: MJ
authors.lastname: Zhang
authors.forename: Xiao-Xiao
authors.initials: XX
authors.lastname: Sun
authors.forename: Xiong-Jie
authors.initials: XJ
authors.lastname: Cai
authors.forename: Yun
authors.initials: Y
authors.lastname: Chen
authors.forename: Wen-Hua
authors.initials: WH
authors.lastname: Chen