title: Vitamin A Deficiency Promotes Inflammation by Induction of Type 2 Cytokines in Experimental Ovalbumin-Induced Asthma Murine Model.
abstract: Vitamin A (VA) deficiency is one of the most common malnutrition conditions. Recent reports showed that VA plays an important role in the immune balance; lack of VA could result in enhanced type 2 immune response characterized by increased type 2 cytokine production and type 2 innate lymphoid cell infiltration and activation. Type 2 immune response plays protective role in anti-infection but plays pathological role in asthmatic disease. In order to investigate the role of VA in the asthmatic disease, we used ovalbumin-induced asthma murine model and observed the pathological changes between mouse-received VA-deficient and VA-sufficient diets. We also measured the type 2 cytokine expressions to reveal the potential mechanism. Our results showed that VA deficiency exacerbates ovalbumin-induced lung inflammation and type 2 cytokine productions. Thus, VA deficiency, or malnutrition in further extent, may contribute to the increasing prevalence of asthma.
authors.affiliation: Department of Nutrition and Food Hygiene, School of Public Health, Jilin University, Changchun, 130021, People's Republic of China.
authors.forename: Weiwei
authors.initials: W
authors.lastname: Cui
authors.affiliation: Department of Thoracic Surgery, The First Hospital of Jilin University, Changchun, 130021, People's Republic of China.
authors.forename: Peng
authors.initials: P
authors.lastname: Zhang
authors.affiliation: College of Veterinary Medicine, Jilin University, Changchun, 130062, People's Republic of China.
authors.forename: Jingmin
authors.initials: J
authors.lastname: Gu
authors.affiliation: Department of Immunology, College of Basic Medical Sciences, Jilin University, 126 Xinmin Avenue, Changchun, 130021, People's Republic of China.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Tian
authors.affiliation: Department of Thoracic Surgery, The First Hospital of Jilin University, Changchun, 130021, People's Republic of China.|Department of Hepatology, First Hospital of Jilin University, Changchun, 130021, People's Republic of China.
authors.forename: Xiuzhu
authors.initials: X
authors.lastname: Gao
authors.affiliation: Department of Immunology, College of Basic Medical Sciences, Jilin University, 126 Xinmin Avenue, Changchun, 130021, People's Republic of China.
authors.forename: Yaqing
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Department of Immunology, College of Basic Medical Sciences, Jilin University, 126 Xinmin Avenue, Changchun, 130021, People's Republic of China.
authors.forename: Zheng
authors.initials: Z
authors.lastname: Jin
authors.affiliation: Department of Immunology, College of Basic Medical Sciences, Jilin University, 126 Xinmin Avenue, Changchun, 130021, People's Republic of China.
authors.forename: Dongmei
authors.initials: D
authors.lastname: Yan
authors.affiliation: Department of Immunology, College of Basic Medical Sciences, Jilin University, 126 Xinmin Avenue, Changchun, 130021, People's Republic of China. zxunzhux@vip.sohu.com.
authors.forename: Xun
authors.initials: X
authors.lastname: Zhu
authors.affiliation: Department of Immunology, College of Basic Medical Sciences, Jilin University, 126 Xinmin Avenue, Changchun, 130021, People's Republic of China. lidong1@jlu.edu.cn.
authors.forename: Dong
authors.identifier: http://orcid.org/0000-0002-2508-3282
authors.initials: D
authors.lastname: Li
mesh_terms: D000818:Animals; D001249:Asthma / Q000209:etiology / Q000276:immunology; D016207:Cytokines / Q000096:biosynthesis / Q000235:genetics; D007249:Inflammation / Q000209:etiology; D051379:Mice; D010047:Ovalbumin; D015533:Transcriptional Activation; D014802:Vitamin A Deficiency / Q000150:complications / Q000378:metabolism / Q000473:pathology*
chemical_list: D016207:Cytokines; D010047:Ovalbumin
keywords: asthma; cytokines; inflammation; vitamin A