title: Tracing the tissue of origin of plasma DNA-feasibility and implications.
abstract: Scientists have been exploring cell-free DNA in plasma for a wider clinical application in addition to noninvasive prenatal testing. Tracing the tissue of origin of plasma DNA is the next important step. In this perspective, we discuss different approaches recently reported for tracing the tissue of origin of plasma DNA and the implications.
authors.affiliation: Department of Chemical Pathology, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong SAR, China. loym@cuhk.edu.hk.|Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong SAR, China. loym@cuhk.edu.hk.
authors.forename: Yuk Ming Dennis
authors.initials: YM
authors.lastname: Lo
authors.affiliation: Department of Chemical Pathology, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong SAR, China.
authors.forename: Wai Kei Jacky
authors.initials: WK
authors.lastname: Lam
mesh_terms: D004247:DNA / Q000097:blood*; D019175:DNA Methylation / Q000235:genetics; D044127:Epigenesis, Genetic; D005240:Feasibility Studies; D006801:Humans; D009928:Organ Specificity
chemical_list: D004247:DNA
keywords: epigenetics; liquid biopsy; methylation; plasma DNA; tumor markers