title: Associated Clinical and Laboratory Markers of Donor on Allograft Function After Heart Transplant.
abstract: Primary graft dysfunction is a major cause of mortality after heart transplantation.
  
  
  
  To evaluate correlations between donor-related clinical/biochemical markers and the occurrence of primary graft dysfunction/clinical outcomes of recipients within 30 days of transplant.
  
  
  
  The prospective study involved 43 donor/recipient pairs. Data collected from donors included demographic and echocardiographic information, noradrenaline administration rates and concentrations of soluble tumor necrosis factor receptors (sTNFR1 and sTNFR2), interleukins (IL-6 and IL-10), monocyte chemoattractant protein-1, C-reactive protein and cardiac troponin I. Data collected from recipients included operating, cardiopulmonary bypass, intensive care unit and hospitalization times, inotrope administration and left/right ventricular function through echocardiography.
  
  
  
  Recipients who developed moderate/severe left ventricular dysfunction had received organs from significantly older donors (P =0.020). Recipients from donors who required moderate/high doses of noradrenaline (>0.23 µg/kg/min) around harvesting time exhibited lower post-transplant ventricular ejection fractions (P =0.002) and required longer CPB times (P =0.039). Significantly higher concentrations of sTNFR1 (P =0.014) and sTNFR2 (P =0.030) in donors were associated with reduced intensive care unit times (≤5 days) in recipients, while higher donor IL-6 (P =0.029) and IL-10 (P =0.037) levels were correlated with reduced hospitalization times (≤25 days) in recipients. Recipients who required moderate/high levels of noradrenaline for weaning off cardiopulmonary bypass were associated with lower donor concentrations of sTNFR2 (P =0.028) and IL-6 (P =0.001).
  
  
  
  High levels of sTNFR1, sTNFR2, IL-6 and IL-10 in donors were associated with enhanced evolution in recipients. Allografts from older donors, or from those treated with noradrenaline doses >0.23 µg/kg/min, were more frequently affected by primary graft dysfunction within 30 days of surgery.
authors.affiliation: Federal University of Minas Gerais, Belo Horizonte, MG, Brazil.
authors.forename: Renato
authors.initials: R
authors.lastname: Braulio
authors.affiliation: Federal University of Minas Gerais, Belo Horizonte, MG, Brazil.
authors.forename: Marcelo Dias
authors.initials: MD
authors.lastname: Sanches
authors.affiliation: Federal University of Minas Gerais, Belo Horizonte, MG, Brazil.
authors.forename: Antonio Lúcio
authors.initials: AL
authors.lastname: Teixeira Junior
authors.affiliation: Federal University of Minas Gerais, Belo Horizonte, MG, Brazil.
authors.forename: Paulo Henrique Nogueira
authors.initials: PH
authors.lastname: Costa
authors.affiliation: Federal University of Minas Gerais, Belo Horizonte, MG, Brazil.
authors.forename: Maria da Consolação Vieira
authors.initials: Mda C
authors.lastname: Moreira
authors.affiliation: Federal University of Minas Gerais, Belo Horizonte, MG, Brazil.
authors.forename: Monaliza Angela
authors.initials: MA
authors.lastname: Rocha
authors.affiliation: Federal University of Minas Gerais, Belo Horizonte, MG, Brazil.
authors.forename: Silvio Amadeu de
authors.initials: SA
authors.lastname: Andrade
authors.affiliation: Federal University of Minas Gerais, Belo Horizonte, MG, Brazil.
authors.forename: Cláudio Léo
authors.initials: CL
authors.lastname: Gelape
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D064591:Allografts / Q000503:physiopathology; D015415:Biomarkers / Q000097:blood; D046148:Donor Selection / Q000592:standards; D005260:Female; D016027:Heart Transplantation / Q000401:mortality / Q000592:standards*; D006801:Humans; D007378:Interleukins / Q000032:analysis; D008297:Male; D008875:Middle Aged; D009638:Norepinephrine / Q000008:administration & dosage* / Q000009:adverse effects; D011184:Postoperative Period; D055031:Primary Graft Dysfunction / Q000097:blood* / Q000209:etiology; D011446:Prospective Studies; D018124:Receptors, Tumor Necrosis Factor / Q000032:analysis; D014019:Tissue Donors; D055815:Young Adult
chemical_list: D015415:Biomarkers; D007378:Interleukins; D018124:Receptors, Tumor Necrosis Factor; D009638:Norepinephrine