title: Anti-flavivirus Activity of Different Tritylated Pyrimidine and Purine Nucleoside Analogues.
abstract: A series of tritylated and dimethoxytritylated analogues of selected pyrimidine and purine nucleosides were synthesized and evaluated for their in vitro inhibitory activity against two important members of the genus Flavivirus in the Flaviviridae family, the yellow fever (YFV) and dengue viruses (DENV). Among all compounds tested, the 5'-O-tritylated and the 5'-O-dimethoxytritylated 5-fluorouridine derivatives exerted potency against YFV. Interestingly in the series of purine analogues, the 5'O, N-bis-tritylated fludarabine derivative revealed strong inhibitory activity against DENV at μm concentrations, however significantly weaker potency against YFV.
authors.affiliation: School of Pharmacy and Pharmaceutical Sciences Cardiff University King Edward VII Avenue Cardiff CF10 3NB United Kingdom.
authors.forename: Christopher
authors.initials: C
authors.lastname: McGuigan
authors.affiliation: School of Pharmacy and Pharmaceutical Sciences Cardiff University King Edward VII Avenue Cardiff CF10 3NB United Kingdom.
authors.forename: Michaela
authors.initials: M
authors.lastname: Serpi
authors.affiliation: School of Pharmacy and Pharmaceutical Sciences Cardiff University King Edward VII Avenue Cardiff CF10 3NB United Kingdom.
authors.forename: Magdalena
authors.initials: M
authors.lastname: Slusarczyk
authors.affiliation: School of Pharmacy and Pharmaceutical Sciences Cardiff University King Edward VII Avenue Cardiff CF10 3NB United Kingdom.
authors.forename: Valentina
authors.initials: V
authors.lastname: Ferrari
authors.affiliation: School of Pharmacy and Pharmaceutical Sciences Cardiff University King Edward VII Avenue Cardiff CF10 3NB United Kingdom.
authors.forename: Fabrizio
authors.initials: F
authors.lastname: Pertusati
authors.affiliation: School of Pharmacy and Pharmaceutical Sciences Cardiff University King Edward VII Avenue Cardiff CF10 3NB United Kingdom.
authors.forename: Silvia
authors.initials: S
authors.lastname: Meneghesso
authors.affiliation: School of Pharmacy and Pharmaceutical Sciences Cardiff University King Edward VII Avenue Cardiff CF10 3NB United Kingdom.
authors.forename: Marco
authors.initials: M
authors.lastname: Derudas
authors.affiliation: Medical Microbiology and Infectious Diseases School of Medicine Cardiff University Heath Park Cardiff CF14 4XN United Kingdom.
authors.forename: Laura
authors.initials: L
authors.lastname: Farleigh
authors.affiliation: Medical Microbiology and Infectious Diseases School of Medicine Cardiff University Heath Park Cardiff CF14 4XN United Kingdom.
authors.forename: Paola
authors.initials: P
authors.lastname: Zanetta
authors.affiliation: Medical Microbiology and Infectious Diseases School of Medicine Cardiff University Heath Park Cardiff CF14 4XN United Kingdom.
authors.forename: Joachim
authors.initials: J
authors.lastname: Bugert
keywords: 4,4′-dimetoxytrityl; antiviral; dengue; flavivirus; nucleoside analogues; trityl; yellow fever