title: Paraneoplastic fibrillary glomerulonephritis associated with intrahepatic cholangiocarcinoma: When diagnosis of a rare kidney disease leads to successful hepatic cancer treatment.
abstract: A 50-year-old man presented with nephrotic syndrome. Electron microscopy analysis of a kidney biopsy specimen showed fibrillary glomerulonephritis, a rare glomerular disease, while histological analysis of a liver tumor biopsy confirmed an intrahepatic cholangiocarcinoma. The paraneoplastic nature of fibrillary glomerulonephritis is debated but after curative treatment of the hepatic nodule, remission of nephrotic syndrome was confirmed at 6-, 12- and 24-months follow-up. To our knowledge, this is the first description of a paraneoplastic fibrillary glomerulonephritis associated with a cholangiocarcinoma, supported by complete remission achieved following cancer treatment.
authors.affiliation: Service de néphrologie clinique, Hôpital Edouard Herriot, Hospices Civils de Lyon, Lyon, France. Electronic address: gl.normand@hotmail.fr.
authors.forename: Gabrielle
authors.initials: G
authors.lastname: Normand
authors.affiliation: Service de néphrologie clinique, Hôpital Edouard Herriot, Hospices Civils de Lyon, Lyon, France.
authors.forename: Anne
authors.initials: A
authors.lastname: Jolivot
authors.affiliation: Service d'anatomopathologie, Hôpital Edouard Herriot, Hospices Civils de Lyon, Lyon, France.
authors.forename: Maud
authors.initials: M
authors.lastname: Rabeyrin
authors.affiliation: Service d'anatomopathologie, Hôpital Edouard Herriot, Hospices Civils de Lyon, Lyon, France.
authors.forename: Valérie
authors.initials: V
authors.lastname: Hervieu
authors.affiliation: Service d'anatomopathologie, CHU de Poitiers, Poitiers, France.
authors.forename: Pierre-Jean
authors.initials: PJ
authors.lastname: Valette
authors.affiliation: Service de radiologie, Hôpital Edouard Herriot, Hospices Civils de Lyon, Lyon, France.
authors.forename: Jean-Yves
authors.initials: JY
authors.lastname: Scoazec
authors.affiliation: Service de radiologie, Centre Hospitalier Lyon Sud, Hospices Civils de Lyon, Pierre-Bénite, France.
authors.forename: Jean-Michel
authors.initials: JM
authors.lastname: Gougon
authors.affiliation: Service de néphrologie clinique, Hôpital Edouard Herriot, Hospices Civils de Lyon, Lyon, France.
authors.forename: Laurent
authors.initials: L
authors.lastname: Juillard
authors.affiliation: Service d'hépato-gastro-entérologie, Hôpital Edouard Herriot, Hospices Civils de Lyon, Lyon, France.
authors.forename: Jérôme
authors.initials: J
authors.lastname: Dumortier
mesh_terms: D001650:Bile Duct Neoplasms / Q000150:complications / Q000175:diagnosis* / Q000628:therapy; D018281:Cholangiocarcinoma / Q000150:complications / Q000175:diagnosis* / Q000628:therapy; D003937:Diagnosis, Differential; D005921:Glomerulonephritis / Q000150:complications / Q000175:diagnosis* / Q000401:mortality / Q000628:therapy; D006801:Humans; D008297:Male; D008875:Middle Aged; D009365:Neoplasm Regression, Spontaneous; D010257:Paraneoplastic Syndromes / Q000150:complications / Q000175:diagnosis* / Q000401:mortality / Q000628:therapy