title: Adrenal insufficiency presenting as hypercalcemia and acute kidney injury.
abstract: Adrenal insufficiency is an uncommon cause of hypercalcemia and not easily considered as an etiology of adrenal insufficiency in clinical practice, as not all cases of adrenal insufficiency manifest as hypercalcemia. We report a case of secondary adrenal insufficiency presenting as hypercalcemia and acute kidney injury in a 66-year-old female. The patient was admitted to the emergency department with general weakness and poor oral intake. Hypercalcemia (11.5 mg/dL) and moderate renal dysfunction (serum creatinine 4.9 mg/dL) were shown in her initial laboratory findings. Studies for malignancy and hyperparathyroidism showed negative results. Basal cortisol and adrenocorticotropic hormone levels and adrenocorticotropic hormone stimulation test confirmed the diagnosis of adrenal insufficiency. With the administration of oral hydrocortisone, hypercalcemia was dramatically resolved within 3 days. This case shows that adrenal insufficiency may manifest as hypercalcemia and acute kidney injury, which implicates that adrenal insufficiency should be considered a cause of hypercalcemia in clinical practice.
authors.affiliation: Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul.
authors.forename: Seung Won
authors.initials: SW
authors.lastname: Ahn
authors.affiliation: Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul.
authors.forename: Tong Yoon
authors.initials: TY
authors.lastname: Kim
authors.affiliation: Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul.
authors.forename: Sangmin
authors.initials: S
authors.lastname: Lee
authors.affiliation: Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul.
authors.forename: Jeong Yeon
authors.initials: JY
authors.lastname: Jeong
authors.affiliation: Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul.
authors.forename: Hojoon
authors.initials: H
authors.lastname: Shim
authors.affiliation: Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul.
authors.forename: Yu Min
authors.initials: YM
authors.lastname: Han
authors.affiliation: Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul.
authors.forename: Kyu Eun
authors.initials: KE
authors.lastname: Choi
authors.affiliation: Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul; Division of Nephrology, Department of Internal medicine, Incheon St. Mary's Hospital, Incheon, Republic of Korea.
authors.forename: Seok Joon
authors.initials: SJ
authors.lastname: Shin
authors.affiliation: Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul; Division of Nephrology, Department of Internal medicine, Incheon St. Mary's Hospital, Incheon, Republic of Korea.
authors.forename: Hye Eun
authors.initials: HE
authors.lastname: Yoon
keywords: acute kidney injury; adrenal insufficiency; hypercalcemia