title: Development of Standard Reference Materials to support assessment of iodine status for nutritional and public health purposes.
abstract: The use of urinary iodine as an indicator of iodine status relies in part on the accuracy of the analytical measurement of iodine in urine. Likewise, the use of dietary iodine intake as an indicator of iodine status relies in part on the accuracy of the analytical measurement of iodine in dietary sources, including foods and dietary supplements. Similarly, the use of specific serum biomarkers of thyroid function to screen for both iodine deficiency and iodine excess relies in part on the accuracy of the analytical measurement of those biomarkers. The National Institute of Standards and Technology has been working with the NIH Office of Dietary Supplements for several years to develop higher-order reference measurement procedures and Standard Reference Materials to support the validation of new routine analytical methods for iodine in foods and dietary supplements, for urinary iodine, and for several serum biomarkers of thyroid function including thyroid-stimulating hormone, thyroglobulin, total and free thyroxine, and total and free triiodothyronine. These materials and methods have the potential to improve the assessment of iodine status and thyroid function in observational studies and clinical trials, thereby promoting public health efforts related to iodine nutrition.
authors.affiliation: Chemical Sciences Division, Material Measurement Laboratory, National Institute of Standards and Technology, Charleston, SC, and stephen.long@nist.gov.
authors.forename: Stephen E
authors.initials: SE
authors.lastname: Long
authors.affiliation: Chemical Sciences Division, Material Measurement Laboratory, National Institute of Standards and Technology, Charleston, SC, and.
authors.forename: Brittany L
authors.initials: BL
authors.lastname: Catron
authors.affiliation: Chemical Sciences Division, Material Measurement Laboratory, National Institute of Standards and Technology, Charleston, SC, and.
authors.forename: Ashley Sp
authors.initials: AS
authors.lastname: Boggs
authors.affiliation: Gaithersburg, MD.
authors.forename: Susan Sc
authors.initials: SS
authors.lastname: Tai
authors.affiliation: Gaithersburg, MD.
authors.forename: Stephen A
authors.initials: SA
authors.lastname: Wise
mesh_terms: D015415:Biomarkers / Q000097:blood / Q000652:urine; D004032:Diet; D019587:Dietary Supplements; D005260:Female; D006801:Humans; D007455:Iodine / Q000172:deficiency; D008297:Male; D015596:Nutrition Assessment; D009751:Nutritional Requirements; D009752:Nutritional Status; D044343:Overnutrition; D011247:Pregnancy; D011634:Public Health; D012016:Reference Values; D013954:Thyroglobulin / Q000097:blood; D013961:Thyroid Gland / Q000378:metabolism*; D013972:Thyrotropin / Q000097:blood; D013974:Thyroxine / Q000097:blood; D014284:Triiodothyronine / Q000097:blood
chemical_list: D015415:Biomarkers; D014284:Triiodothyronine; D013972:Thyrotropin; D013954:Thyroglobulin; D007455:Iodine; D013974:Thyroxine
keywords: clinical laboratory; iodine; quality control; reference materials; standardization; thyroid function tests