title: CHOROIDAL BLOOD FLOW VISUALIZATION IN HIGH MYOPIA USING A PROJECTION ARTIFACT METHOD IN OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY.
abstract: OBJECTIVE
  To visualize choroidal blood flow in larger vessels in highly myopic eyes using a phenomenon of the projection artifact to in the sclera using optical coherence tomography angiography.
  
  
  METHODS
  The retrospective study included 92 eyes (54 patients) with greater than 8 diopters of myopia. All eyes were examined using optical coherence tomography angiography (RTVue XR Avanti; Optovue Inc, Fremont, CA). The blood flow in choroidal vessels was evaluated by attempting to directly segment the choroid and also by placing the segmentation layer behind the choroid, within the sclera. Subfoveal choroidal thickness was also measured at the same time. The authors also evaluated the 54 normal eyes (54 cases) without high myopia as a control group.
  
  
  RESULTS
  Segmentation artifacts occurred in 68 cases (73.9%) and precluded direct visualization of the choroidal blood flow in larger vessels. When the segmentation slab was placed posterior to the choroid within the sclera, the choroidal blood flow was visualized in 41 eyes (44.6%). The mean subfoveal choroidal thickness in eyes with visualization of choroidal blood flow was thinner than without visualization (50.3 ± 42.2 μm vs. 100.3 ± 44.4 μm, P < 0.01). Choroidal blood flow in larger vessels was imaged in no control eye.
  
  
  CONCLUSIONS
  The choroidal vessel anatomy could be imaged by detecting flow using the projection artifact in the sclera with optical coherence tomography angiography. This technique may be useful in estimating the vascularity of the choroid.
authors.affiliation: *Department of Ophthalmology, Tokyo Women's Medical University School of Medicine, Shinjuku, Tokyo, Japan; and †Vitreous Retina Macula Consultants of New York, New York, New York.
authors.forename: Ichiro
authors.initials: I
authors.lastname: Maruko
authors.forename: Richard F
authors.initials: RF
authors.lastname: Spaide
authors.forename: Hideki
authors.initials: H
authors.lastname: Koizumi
authors.forename: Shota
authors.initials: S
authors.lastname: Sawaguchi
authors.forename: Takahiko
authors.initials: T
authors.lastname: Izumi
authors.forename: Taiji
authors.initials: T
authors.lastname: Hasegawa
authors.forename: Hisaya
authors.initials: H
authors.lastname: Arakawa
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Iida
mesh_terms: D016477:Artifacts; D058452:Axial Length, Eye / Q000473:pathology; D001783:Blood Flow Velocity / Q000502:physiology; D001808:Blood Vessels / Q000473:pathology*; D002829:Choroid / Q000098:blood supply* / Q000473:pathology; D000072226:Computed Tomography Angiography / Q000379:methods; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D047728:Myopia, Degenerative / Q000503:physiopathology*; D012039:Regional Blood Flow / Q000502:physiology; D012189:Retrospective Studies; D041623:Tomography, Optical Coherence / Q000379:methods*