title: Bifunctional-Phosphine-Catalyzed Sequential Annulations of Allenoates and Ketimines: Construction of Functionalized Poly-heterocycle Rings.
abstract: A highly stereoselective sequential annulation reaction between γ-substituted allenoates and ketimines was reported. By using bifunctional N-acyl aminophosphine catalysts, poly-heterocycle rings were obtained with high stereocontrol in good to excellent yields. The desired products have four contiguous stereogenic centers (one quaternary and three tertiary carbon centers), and only one isomer was obtained in all reactions.
authors.affiliation: State Key Laboratory and Institute of Elemento-Organic Chemistry, Nankai University, Tianjin, 300071, China.
authors.forename: Erqing
authors.initials: E
authors.lastname: Li
authors.affiliation: State Key Laboratory and Institute of Elemento-Organic Chemistry, Nankai University, Tianjin, 300071, China.
authors.forename: Hongxing
authors.initials: H
authors.lastname: Jin
authors.affiliation: State Key Laboratory and Institute of Elemento-Organic Chemistry, Nankai University, Tianjin, 300071, China.
authors.forename: Penghao
authors.initials: P
authors.lastname: Jia
authors.affiliation: State Key Laboratory and Institute of Elemento-Organic Chemistry, Nankai University, Tianjin, 300071, China.
authors.forename: Xuelin
authors.initials: X
authors.lastname: Dong
authors.affiliation: State Key Laboratory and Institute of Elemento-Organic Chemistry, Nankai University, Tianjin, 300071, China. hyou@nankai.edu.cn.|Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Tianjin, 300071, China. hyou@nankai.edu.cn.
authors.forename: You
authors.initials: Y
authors.lastname: Huang
keywords: allenoates; bifunctional phosphines; domino reaction; poly-heterocycle rings; sequential annulations