title: Spectroscopic Studies on the Interaction of Pyridinoline Cross-Linking in Type 1 Collagen with ZIF8-HB.
abstract: Many kinds of fibrosis are related to the content of pyridinoline cross-linking in type 1 collagen. In this study, ZIF-8 (zeolitic imidazolate framework), a metal organic framework (MOF), and ZIF8-hypocrellin B (ZIF8-HB), which combined the merits of hypocrellin B and the properties of ZIF-8, were prepared and applied to the photodegradation of the pyridinoline cross-linking. The effects of O2 and H2O2 in the photodynamic action were investigated. The results indicate that ZIF8-HB is an efficient photosensitizer to decompose pyridinoline cross-linking in collagen.
authors.affiliation: Key Laboratory of Natural Pharmaceutical & Chemical Biology of Yunnan Province, Honghe University, Mengzi, Yunnan Province, China.|College of Science, Honghe University, Mengzi, Yunnan Province, China.
authors.forename: Yashun
authors.initials: Y
authors.lastname: Chen
authors.affiliation: College of Life Science and Technology, Honghe University, Mengzi, Yunnan Province, China.
authors.forename: Fangfang
authors.initials: F
authors.lastname: He
authors.affiliation: Key Laboratory of Natural Pharmaceutical & Chemical Biology of Yunnan Province, Honghe University, Mengzi, Yunnan Province, China.|College of Science, Honghe University, Mengzi, Yunnan Province, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Liu
authors.affiliation: Key Laboratory of Natural Pharmaceutical & Chemical Biology of Yunnan Province, Honghe University, Mengzi, Yunnan Province, China. juchengzhang@163.com.|College of Science, Honghe University, Mengzi, Yunnan Province, China. juchengzhang@163.com.
authors.forename: Jucheng
authors.initials: J
authors.lastname: Zhang
mesh_terms: D000596:Amino Acids / Q000737:chemistry* / Q000528:radiation effects; D024042:Collagen Type I / Q000737:chemistry* / Q000528:radiation effects; D056831:Coordination Complexes / Q000737:chemistry*; D006861:Hydrogen Peroxide / Q000737:chemistry; D008956:Models, Chemical; D009942:Organometallic Compounds / Q000737:chemistry*; D010100:Oxygen / Q000737:chemistry; D010569:Perylene / Q000031:analogs & derivatives* / Q000737:chemistry; D010782:Photolysis; D017319:Photosensitizing Agents / Q000737:chemistry*; D059748:Proteolysis; D011809:Quinones / Q000737:chemistry*; D013050:Spectrometry, Fluorescence; D013997:Time Factors
chemical_list: D000596:Amino Acids; D024042:Collagen Type I; D056831:Coordination Complexes; D009942:Organometallic Compounds; D017319:Photosensitizing Agents; D011809:Quinones; D010569:Perylene; C015484:pyridinoline; D006861:Hydrogen Peroxide; D010100:Oxygen
keywords: Fibrosis; Fluorescence; Hydroxyl radical; Photosensitizer; ZIF8-HB