title: Brain Metastases Mimicking Hyperostosis Frontalis Interna on 99mTc HDP Bone Scintigraphy.
abstract: Symmetric bifrontal uptake of bone-seeking agents is usually considered as the main feature of hyperostosis frontalis interna in postmenopausal elderly women. This finding is not uncommon in elderly women because of the change in their hormonal level. However, in the present case, a 66-year-old woman with intra-axial brain metastases of breast cancer showed symmetric bifrontal uptake on bone scintigraphy. Therefore, symmetric bifrontal uptake should not always be considered as a definite indicator of hyperostosis frontalis interna. Further evaluation such as SPECT/CT is needed for evaluation of brain metastases especially in cancer patients.
authors.affiliation: From the *Department of Nuclear Medicine, Chonnam National University Hospital, and †Chonnam National University Hwasun Hospital, Gwangju; and ‡Chonbuk National University Hospital, Jeonju, Republic of Korea.
authors.forename: Sae-Ryung
authors.initials: SR
authors.lastname: Kang
authors.forename: Jahae
authors.initials: J
authors.lastname: Kim
authors.forename: Seong Young
authors.initials: SY
authors.lastname: Kwon
authors.forename: Jung-Joon
authors.initials: JJ
authors.lastname: Min
authors.forename: Hee-Seung
authors.initials: HS
authors.lastname: Bom
authors.forename: Myung-Hee
authors.initials: MH
authors.lastname: Sohn
authors.forename: Ho-Chun
authors.initials: HC
authors.lastname: Song
mesh_terms: D000368:Aged; D001932:Brain Neoplasms / Q000000981:diagnostic imaging* / Q000556:secondary; D001943:Breast Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology*; D003937:Diagnosis, Differential; D004164:Diphosphonates; D005260:Female; D006801:Humans; D006957:Hyperostosis Frontalis Interna / Q000000981:diagnostic imaging*; D015609:Organotechnetium Compounds; D019275:Radiopharmaceuticals; D000072098:Single Photon Emission Computed Tomography Computed Tomography
chemical_list: D004164:Diphosphonates; D015609:Organotechnetium Compounds; D019275:Radiopharmaceuticals; C060491:technetium Tc 99m hydroxydiphosphonate