title: The effect of fundus resection on weight loss and ghrelin levels in rats.
abstract: BACKGROUND
  Ghrelin is a 28-amino acid peptide that is isolated mainly from the oxyntic glands of the stomach, especially fundus. Ghrelin administration, either centrally or peripherally, increases food intake and body weight in both rodents and humans. This study evaluates the effects of fundus resection and sclerosing agent injection on ghrelin level and weight loss.
  
  
  METHODS
  Thirty rats were divided into three groups. In group 1, NaCl was injected into the submucosal space at the gastric fundus while in Group 2, a sclerosing agent was injected into the latter site. In group 3, gastric fundus was resected. Ghrelin levels and weight were recorded.
  
  
  RESULTS
  In group 1, rats continued gaining weight and ghrelin levels stayed stable. In group 2, rats' weight and ghrelin levels stayed stable and in group 3, while weight stayed stable, ghrelin levels decreased significantly.
  
  
  CONCLUSIONS
  In rats, the resection of fundus stabilizes weight gain and decreases ghrelin levels. However, in sclerotherapy, although weight gain was stabilized, there was no decrease in ghrelin levels. In humans, the effect of fundus resection on weight gain can usher in a new era of investigation (Tab. 2, Ref. 16).
authors.forename: A
authors.initials: A
authors.lastname: Okus
authors.forename: B
authors.initials: B
authors.lastname: Sevinc
authors.forename: O
authors.initials: O
authors.lastname: Karahan
authors.forename: S
authors.initials: S
authors.lastname: Ay
authors.forename: S
authors.initials: S
authors.lastname: Civcik
mesh_terms: D000818:Animals; D001835:Body Weight / Q000187:drug effects*; D005748:Gastric Fundus / Q000187:drug effects* / Q000378:metabolism / Q000601:surgery; D005753:Gastric Mucosa / Q000187:drug effects* / Q000378:metabolism / Q000601:surgery; D054439:Ghrelin / Q000187:drug effects* / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D012597:Sclerosing Solutions / Q000494:pharmacology*; D015431:Weight Loss / Q000187:drug effects*
chemical_list: D054439:Ghrelin; D012597:Sclerosing Solutions
keywords: fundus resection; ghrelin.; sclerotherapy