title: [THE FREQUENCY OF ADVERSE REACTIONS TO ANTITUBERCULOUS AGENTS IN FIRST DETECTED PATIENTS OLDER THAN 18 YEARS WITH PULMONARY TUBERCULOSIS AND THE FACTORS INFLUENCING THEIR DEVELOPMENT].
abstract: The study was conducted at Omsk Regional Clinical Tuberculosis Dispensary Four in 2003-2007. The frequency of adverse reactions was studied in 485 patients aged 18 to 84 years. Adverse reactions were found to complicate chemotherapy in 67.8% of cases; 2.5% of the patients developed 2 types of adverse reactions or more. The bulk (67.1%) of adverse reactions developed within the first 2 months of chemotherapy and was associated with treatment regimen I. Age older than 60 years, comorbidity, the asymptomatic course of the disease are the major factors predisposing to their development. The development of adverse reactions substantially lowers the efficiency of treatment in new cases of tuberculosis.
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000995:Antitubercular Agents / Q000008:administration & dosage / Q000009:adverse effects; D058345:Asymptomatic Infections / Q000453:epidemiology*; D015897:Comorbidity; D004359:Drug Therapy, Combination / Q000379:methods; D064420:Drug-Related Side Effects and Adverse Reactions / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology; D006763:Hospitals, Chronic Disease / Q000706:statistics & numerical data; D006801:Humans; D008297:Male; D008875:Middle Aged; D018570:Risk Assessment; D012307:Risk Factors; D012800:Siberia / Q000453:epidemiology; D016896:Treatment Outcome; D014397:Tuberculosis, Pulmonary / Q000175:diagnosis / Q000188:drug therapy / Q000503:physiopathology
chemical_list: D000995:Antitubercular Agents