title: [Association between genetic variants in microRNA biosynthesis genes and the risk of head and neck squamous cell carcinoma].
abstract: OBJECTIVE
  To investigate the association between genetic variants in microRNA biosynthesis genes and the risk of head and neck squamous cell carcinoma (HNSCC).
  
  
  METHODS
  A case-control study was conducted with 576 HNSCC patients and 1 552 healthy controls matched by factors as age-(±5 years) and sex. Eight potentially functional single nucleotide polymorphism loci in microRNA biosynthesis genes (DICER1, GEMIN3, and PIWIL1) were genotyped using the Illumina Infinium BeadChip platform. Univariate and multivariate logistic regression models were performed to assess the association between genotypes and HNSCC risk.
  
  
  RESULTS
  The allele frequencies of rs1106042 (G> A) in PIWIL1 were significantly different between the cases and controls (P=0.011). After controlling for factors as age, sex, smoking and alcohol intake, the A allele of rs1106042 showed a decreased risk of HNSCC (additive model: adjusted OR=0.73, 95% CI: 0.57-0.93, P=0.011). RESULTS from the stratification analysis by age, sex, smoking, alcohol intake and tumor sites showed that the effect of rs1106042 A allele on HNSCC risk was significant in older age groups (≥60), females, nonsmokers, non-alcohol drinkers, and subjects with oral cavity cancer (P<0.05).
  
  
  CONCLUSIONS
  Potentially, functional single nucleotide polymorphism in PIWIL1 might modify the risk of HNSCC in China.
authors.affiliation: Department of Epidemiology, School of Public Health, Nanjing Medical University, Nanjing 211166, China.
authors.forename: W W
authors.initials: WW
authors.lastname: Yuan
authors.affiliation: Department of Epidemiology, School of Public Health, Nanjing Medical University, Nanjing 211166, China.
authors.forename: D
authors.initials: D
authors.lastname: Hang
authors.affiliation: Department of Epidemiology, School of Public Health, Nanjing Medical University, Nanjing 211166, China.
authors.forename: L H
authors.initials: LH
authors.lastname: Wang
authors.affiliation: Department of Epidemiology, School of Public Health, Nanjing Medical University, Nanjing 211166, China.
authors.forename: S H
authors.initials: SH
authors.lastname: Chen
authors.affiliation: Department of Epidemiology, School of Public Health, Nanjing Medical University, Nanjing 211166, China.
authors.forename: Z X
authors.initials: ZX
authors.lastname: Ding
authors.affiliation: Department of Epidemiology, School of Public Health, Nanjing Medical University, Nanjing 211166, China; Jiangsu Key Laboratory of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center for Cancer Personalized Medicine, Nanjing 211166, China.
authors.forename: Z B
authors.initials: ZB
authors.lastname: Hu
authors.affiliation: Department of Epidemiology, School of Public Health, Nanjing Medical University, Nanjing 211166, China; Jiangsu Key Laboratory of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center for Cancer Personalized Medicine, Nanjing 211166, China.
authors.forename: H X
authors.initials: HX
authors.lastname: Ma
mesh_terms: D000328:Adult; D000368:Aged; D000428:Alcohol Drinking; D002294:Carcinoma, Squamous Cell / Q000235:genetics*; D016022:Case-Control Studies; D002681:China; D005260:Female; D005787:Gene Frequency; D014644:Genetic Variation; D005838:Genotype; D006258:Head and Neck Neoplasms / Q000235:genetics*; D006801:Humans; D016015:Logistic Models; D008297:Male; D035683:MicroRNAs / Q000235:genetics*; D008875:Middle Aged; D009062:Mouth Neoplasms; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D012907:Smoking; D000077195:Squamous Cell Carcinoma of Head and Neck
chemical_list: D035683:MicroRNAs