title: Cytosolic DNA Sensing: The Field Narrows.
abstract: The innate response to many pathogens involves type I interferon production that is initiated upon cytosolic detection of double-stranded DNA (dsDNA), but how dsDNA is detected is controversial. In this issue of Immunity, Gray et al. (2016) use genetics to bring some much-needed clarity to the field.
authors.affiliation: Howard Hughes Medical Institute, University of California, Berkeley, Berkeley, CA 94720, USA; Division of Immunology and Pathogenesis, Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA; Cancer Research Laboratory, University of California, Berkeley, Berkeley, CA 94720, USA. Electronic address: rvance@berkeley.edu.
authors.forename: Russell E
authors.initials: RE
authors.lastname: Vance
mesh_terms: D003600:Cytosol; D004247:DNA / Q000276:immunology*
chemical_list: D004247:DNA