title: Increased histone deacetylase activity in peripheral blood mononuclear cells of patients with schizophrenia.
abstract: This study investigates the association between histone deacetylase (HDAC) activity in human peripheral blood mononuclear cells (PBMCs) and schizophrenia. Data were derived from a case-control association study of 19 unrelated adult patients with schizophrenia and 21 matched healthy controls. HDAC activity was measured with a HDAC activity colorimetric assay kit. Our findings suggest that HDAC activity in PBMCs is higher in patients with schizophrenia than in healthy people.
authors.affiliation: Department of Epidemiology and Biostatistics, School of Public Health, Jilin University, Changchun 130021, Jilin.
authors.forename: Bo
authors.initials: B
authors.lastname: Pang
authors.affiliation: Department of Epidemiology and Biostatistics, School of Public Health, Jilin University, Changchun 130021, Jilin.
authors.forename: Jingyi
authors.initials: J
authors.lastname: Wang
authors.affiliation: Department of Epidemiology and Biostatistics, School of Public Health, Jilin University, Changchun 130021, Jilin.
authors.forename: Wenbin
authors.initials: W
authors.lastname: Zhang
authors.affiliation: Department of Epidemiology and Biostatistics, School of Public Health, Jilin University, Changchun 130021, Jilin.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Gao
authors.affiliation: Department of Epidemiology and Biostatistics, School of Public Health, Jilin University, Changchun 130021, Jilin.
authors.forename: Jinrong
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Department of Epidemiology and Biostatistics, School of Public Health, Jilin University, Changchun 130021, Jilin.
authors.forename: Yingying
authors.initials: Y
authors.lastname: Su
authors.affiliation: Department of Epidemiology and Biostatistics, School of Public Health, Jilin University, Changchun 130021, Jilin. Electronic address: koucg@jlu.edu.cn.
authors.forename: Changgui
authors.initials: C
authors.lastname: Kou
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D005260:Female; D006655:Histone Deacetylases / Q000378:metabolism*; D006801:Humans; D007963:Leukocytes, Mononuclear / Q000201:enzymology*; D008297:Male; D012559:Schizophrenia / Q000201:enzymology*; D055815:Young Adult
chemical_list: D006655:Histone Deacetylases
keywords: Histone deacetylases; Human peripheral blood mononuclear cell; Schizophrenia