title: Essential Oil from Origanum vulgare Completely Inhibits the Growth of Multidrug-Resistant Cystic Fibrosis Pathogens.
abstract: Essential oils (EOs) are known to inhibit the growth of a wide range of microorganisms. Particularly interesting is the possible use of EOs to treat multidrug-resistant cystic fibrosis (CF) pathogens. We tested the essential oil (EO) from Origanum vulgare for in vitro antimicrobial activity, against three of the major human opportunistic pathogens responsible for respiratory infections in CF patients; these are methicillin-resistant Staphylococcus aureus, Stenotrophomonas maltophilia and Achromobacter xylosoxidans. Antibiotic susceptibility of each strain was previously tested by the standard disk diffusion method. Most strains were resistant to multiple antibiotics and could be defined as multi-drug-resistant (MDR). The antibacterial activity of O. vulgare EO (OEO) against a panel of 59 bacterial strains was evaluated, with MIC and MBC determined at 24, 48 and 72 hours by a microdilution method. The OEO was effective against all tested strains, although to a different extent. The MBC and MIC of OEO for S. aureus strains were either lower or equal to 0.50%, v/v, for A. xylosoxidans strains were lower or equal to 1% and 0.50%, v/v, respectively; and for S. maltophilia strains were lower or equal to 0.25%, v/v. The results from this study suggest that OEO might exert a role as an antimicrobial in the treatment of CF infections.
authors.forename: Giovanna
authors.initials: G
authors.lastname: Pesavento
authors.forename: Valentina
authors.initials: V
authors.lastname: Maggini
authors.forename: Isabel
authors.initials: I
authors.lastname: Maida
authors.forename: Antonella
authors.initials: A
authors.lastname: Lo Nostro
authors.forename: Carmela
authors.initials: C
authors.lastname: Calonico
authors.forename: Chiara
authors.initials: C
authors.lastname: Sassoli
authors.forename: Elena
authors.initials: E
authors.lastname: Perrin
authors.forename: Marco
authors.initials: M
authors.lastname: Fondi
authors.forename: Alessio
authors.initials: A
authors.lastname: Mengoni
authors.forename: Carolina
authors.initials: C
authors.lastname: Chiellini
authors.forename: Alfredo
authors.initials: A
authors.lastname: Vannacci
authors.forename: Eugenia
authors.initials: E
authors.lastname: Gallo
authors.forename: Luigi
authors.initials: L
authors.lastname: Gori
authors.forename: Patrizia
authors.initials: P
authors.lastname: Bogani
authors.forename: Anna Rita
authors.initials: AR
authors.lastname: Bilia
authors.forename: Silvia
authors.initials: S
authors.lastname: Campana
authors.forename: Novella
authors.initials: N
authors.lastname: Ravenni
authors.forename: Daniela
authors.initials: D
authors.lastname: Dolce
authors.forename: Fabio
authors.initials: F
authors.lastname: Firenzuoli
authors.forename: Renato
authors.initials: R
authors.lastname: Fani
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D003550:Cystic Fibrosis / Q000382:microbiology*; D006801:Humans; D008826:Microbial Sensitivity Tests; D009822:Oils, Volatile / Q000494:pharmacology*; D031341:Origanum / Q000737:chemistry*; D010938:Plant Oils / Q000494:pharmacology*; D013211:Staphylococcus aureus / Q000187:drug effects / Q000254:growth & development; D020615:Stenotrophomonas maltophilia / Q000187:drug effects / Q000254:growth & development
chemical_list: D000900:Anti-Bacterial Agents; D009822:Oils, Volatile; D010938:Plant Oils