title: Total intravenous anesthesia with propofol is associated with a lower rate of postoperative delirium in comparison with sevoflurane anesthesia in elderly patients.
abstract: OBJECTIVE
  Postoperative delirium (POD) is a common complication of anesthesia. The incidence of POD in elderly patients ranges from 37% to 53%, and POD increases the morbidity and mortality of elderly patients. However, the effects of anesthetics on POD are not well known. The present study aimed to compare the incidence of POD resulting from propofol and sevoflurane anesthesia.
  
  
  METHODS
  Double-blind prospective study.
  
  
  METHODS
  Operating room and postoperative recovery area.
  
  
  METHODS
  Thirty patients in the sevoflurane anesthesia group and 29 in the propofol anesthesia group.
  
  
  METHODS
  Statistical analyses were performed using Microsoft Excel 2010 for Windows 7 (Microsoft Corporation, Redmond, Wash). Statistical analysis was performed using Fisher exact test and Student t test.
  
  
  RESULTS
  The incidence of POD in the propofol anesthesia (6.9%) was significantly less than that observed in the sevoflurane anesthesia (26.7%; 038).
  
  
  CONCLUSIONS
  In comparison with sevoflurane anesthesia, propofol anesthesia is associated with a lower incidence of POD in elderly patients.
authors.affiliation: Department of Anesthesia, Sasebo City General Hospital, Sasebo, Japan; Department of Anesthesiology, Nagasaki University School of Medicine, Nagasaki, Japan. Electronic address: soukenbicha141kouji@yahoo.co.jp.
authors.forename: Koji
authors.initials: K
authors.lastname: Ishii
authors.affiliation: Department of Anesthesiology, Nagasaki University School of Medicine, Nagasaki, Japan.
authors.forename: Tetsuji
authors.initials: T
authors.lastname: Makita
authors.affiliation: Department of Anesthesia, Sasebo City General Hospital, Sasebo, Japan.
authors.forename: Hikoma
authors.initials: H
authors.lastname: Yamashita
authors.affiliation: Department of Anesthesia, Sasebo City General Hospital, Sasebo, Japan.
authors.forename: Shoji
authors.initials: S
authors.lastname: Matsunaga
authors.affiliation: Department of Anesthesia, Sasebo City General Hospital, Sasebo, Japan.
authors.forename: Daiji
authors.initials: D
authors.lastname: Akiyama
authors.affiliation: Department of Anesthesia, Sasebo City General Hospital, Sasebo, Japan.
authors.forename: Kouko
authors.initials: K
authors.lastname: Toba
authors.affiliation: Department of Anesthesia, Sasebo City General Hospital, Sasebo, Japan.
authors.forename: Katsumi
authors.initials: K
authors.lastname: Hara
authors.affiliation: Department of Anesthesia, Saiseikai Nagasaki Hospital, Nagasaki, Japan.
authors.forename: Koji
authors.initials: K
authors.lastname: Sumikawa
authors.affiliation: Department of Anesthesiology, Nagasaki University School of Medicine, Nagasaki, Japan.
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Hara
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000762:Anesthesia Recovery Period; D000771:Anesthesia, Intravenous / Q000379:methods*; D018685:Anesthetics, Inhalation / Q000009:adverse effects*; D018686:Anesthetics, Intravenous / Q000009:adverse effects*; D003693:Delirium / Q000139:chemically induced* / Q000453:epidemiology* / Q000523:psychology; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D008738:Methyl Ethers / Q000009:adverse effects*; D011183:Postoperative Complications / Q000139:chemically induced* / Q000453:epidemiology* / Q000523:psychology; D015742:Propofol / Q000009:adverse effects*; D011446:Prospective Studies; D000077149:Sevoflurane
chemical_list: D018685:Anesthetics, Inhalation; D018686:Anesthetics, Intravenous; D008738:Methyl Ethers; D000077149:Sevoflurane; D015742:Propofol
keywords: Elderly patients; Postoperative delirium; Propofol; Sevoflurane