title: Association of Circulating Orexin-A Level With Metabolic Risk Factors in North Indian Pre Menopausal Women.
abstract: The present study was designed to investigate the association between circulating Orexin-A level with metabolic risk factors in North Indian adult women. 342 women were enrolled for the case-control study, 172 women were with metabolic syndrome (mets) and 170 healthy control women were without metabolic syndrome, (womets) according to (NCEP ATP III criteria). Circulating Orexin-A level was determined by enzyme-linked immunosorbent assay. Observations indicated low levels of orexin-A (26.06 ± 6.09 ng/ml) in women with mets and other metabolic risk factors compared to women without metabolic syndrome (36.50 ± 10.42 ng/ml). Further, in women with metabolic syndrome, circulating Orexin A was significantly associated with waist circumference, triglyceride (negative correlation) and hyperdensity lipoprotein (positive correlation). Our study shows that circulating Orexin A was found to be significantly associated with hyperlipidemia, obesity and obesity-related disorders in North Indian premenopausal women.
authors.forename: Vani
authors.initials: V
authors.lastname: Gupta
authors.forename: Sameeksha
authors.initials: S
authors.lastname: Mishra
authors.forename: Sandeep
authors.initials: S
authors.lastname: Kumar
authors.forename: Supriya
authors.initials: S
authors.lastname: Mishra
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D015536:Down-Regulation; D050171:Dyslipidemias / Q000097:blood / Q000175:diagnosis / Q000453:epidemiology; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007194:India / Q000453:epidemiology; D008075:Lipoproteins, HDL / Q000097:blood; D024821:Metabolic Syndrome / Q000097:blood* / Q000175:diagnosis / Q000453:epidemiology; D009765:Obesity / Q000097:blood / Q000175:diagnosis / Q000453:epidemiology; D000068797:Orexins / Q000097:blood*; D017697:Premenopause / Q000097:blood*; D012307:Risk Factors; D014280:Triglycerides / Q000097:blood; D055105:Waist Circumference
chemical_list: D015415:Biomarkers; D008075:Lipoproteins, HDL; D000068797:Orexins; D014280:Triglycerides