title: [Molecular Mechanisms of Functional Activity Decreasing of the Skin Cells With Its Aging].
abstract: The article discusses the pool of signaling molecules that regulate the functional activity of the skin cells. Molecules of apoptosis and cells skin aging are p53, p21, p15, Cdk 4/6 and Bcl-2. Inflammation in skin fibroblasts are realized through the cytokines TNF-α, TGF-β, IL-1, ICAM-1, matrix metalloproteinase MMP-1,2,3,9, transcription factor NF-κB and activator protein AP-1. An important role in the aging of skin cells play neuroimmunoendocrine signaling molecules--melatonin, serotonin, skin fibroblast proliferation marker chromogranin A and CD98hc. Age-related changes in the activity of immune cells of the skin is associated with impaired expression of cluster of differentiation of T-lymphocytes (CD3, CD4, CD5, CD8, CD11) and dendritic cells (CD83⁺). These signaling molecules produced by the fibroblasts of the skin, regulate the activity of immune cells involved in the cascade of reactions associated with inflammatory responses, proliferation, apoptosis and cell regeneration. Based on these data nowadays new highly selective approaches to the diagnosis of the skin and the creation of cosmetic agents for the prevention of aging are developed.
authors.forename: V Kh
authors.initials: VKh
authors.lastname: Khavinson
authors.forename: N S
authors.initials: NS
authors.lastname: Linkova
authors.forename: E O
authors.initials: EO
authors.lastname: Kukanova
authors.forename: O A
authors.initials: OA
authors.lastname: Orlova
mesh_terms: D000375:Aging / Q000235:genetics* / Q000473:pathology; D015703:Antigens, CD / Q000096:biosynthesis / Q000235:genetics; D017209:Apoptosis / Q000235:genetics / Q000502:physiology; D049109:Cell Proliferation / Q000235:genetics / Q000502:physiology; D016207:Cytokines / Q000096:biosynthesis / Q000235:genetics*; D005347:Fibroblasts / Q000378:metabolism / Q000473:pathology; D006801:Humans; D007249:Inflammation / Q000235:genetics* / Q000503:physiopathology; D015398:Signal Transduction / Q000235:genetics / Q000502:physiology; D012867:Skin / Q000378:metabolism* / Q000473:pathology / Q000648:ultrastructure
chemical_list: D015703:Antigens, CD; D016207:Cytokines