title: [Overview of History and New Demands Regarding Clinical Microbiological Tests in Healthcare Facilities].
abstract: Since the 1960s, healthcare-associated infections caused by multi-drug-resistant organisms (MDROs) have been a critical part of hospital quality management. To fight MDROs, diverse antimicrobial agents are developed and used for patients. Recently, super-MDROs such as carbapenemase-producing Enterobacteriaceae (CPE) are spreading throughout the world. There is a chance that such super-MDROs will appear in Japan. For active surveillance (i.e., screening) tests to detect CPE, state-of-the-art methodologies are needed. For example, selective culture media and active surveillance test by real-time PCR, matrix-assisted laser desorption-ionization time-of-flight mass spectrometry (MALDI-TOF MS) technology for bacterial identification, and molecular epidemiological tools such as multi-locus sequence typing (MLST). In this symposium, we discussed updating to state-of-the-art clinical microbiologic technologies in Japanese clinical microbiologic laboratories.
authors.forename: Toshihiro
authors.initials: T
authors.lastname: Mitsuda
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D064790:Clinical Laboratory Services; D003428:Cross Infection / Q000382:microbiology; D004755:Enterobacteriaceae / Q000187:drug effects*; D006801:Humans; D007564:Japan; D060888:Real-Time Polymerase Chain Reaction / Q000379:methods; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
chemical_list: D000900:Anti-Bacterial Agents