title: [Remodeling of Cardiovascular System: Causes and Consequences].
abstract: Literature and our data suggest the regulatory action of a number of biologically active substances (catecholamines, cardiac glycosides, β-blockers, angiotensin-converting-enzyme inhibitor) on the growth and proliferation of heart cells. By using of organotypic tissue culture has proved that the basis of this regulation is the ability of test substances, receptor- or transducer-mediated signaling to modulate the function of Na⁺, K⁺-ATPase. There is a delay in the development of vascular smooth muscle in the late postnatal period in rats with the blockade of the sympathetic nervous system in the prenatal period. The relationship between vascular remodeling and contractile activity is described. It seems that one of the causes of high blood pressure is a remodeling of the cardiovascular system, which precedes the development of hypertension.
authors.forename: E V
authors.initials: EV
authors.lastname: Lopatina
authors.forename: A V
authors.initials: AV
authors.lastname: Kipenko
authors.forename: V A
authors.initials: VA
authors.lastname: Penniyaynen
authors.forename: N A
authors.initials: NA
authors.lastname: Pasatetckaia
authors.forename: V A
authors.initials: VA
authors.lastname: Tsyrline
mesh_terms: D000806:Angiotensin-Converting Enzyme Inhibitors / Q000627:therapeutic use; D000818:Animals; D002319:Cardiovascular System / Q000254:growth & development / Q000503:physiopathology*; D006321:Heart / Q000503:physiopathology; D006801:Humans; D006973:Hypertension / Q000188:drug therapy / Q000378:metabolism / Q000503:physiopathology*; D009131:Muscle, Smooth, Vascular / Q000254:growth & development / Q000503:physiopathology; D032383:Myocytes, Cardiac / Q000378:metabolism* / Q000473:pathology; D051381:Rats; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism; D013564:Sympathetic Nervous System / Q000503:physiopathology*
chemical_list: D000806:Angiotensin-Converting Enzyme Inhibitors; D000254:Sodium-Potassium-Exchanging ATPase