title: Factors influencing the fabrication of albumin-bound drug nanoparticles (ABDns): Part II. Albumin-bound carbamazepine nanoparticles (ABCns).
abstract: Carbamazepine (CBZ) is a BCS Class II drug with poor solubility profile. In order to improve the physicochemical properties of CBZ, albumin (HSA)-bound CBZ nanoparticles (ABCns) were prepared. Drug-loading studies indicated that monomeric ABCns can be fabricated by self-assembly of anhydrous form III of CBZ and HSA in molar ratios of 1:1 or 2:1 within 0.5 h in phosphate buffer pH 7.4 with particle size in the range of 10-20 nm. Approximately 73-76% of the CBZ was encapsulated within HSA and 20-40% CBZ was released from the ABCns over 8 days. In conclusion, novel ABCns can be fabricated with sustained-release of CBZ for over 8 days which can significantly improve the physicochemical profile of CBZ.
authors.affiliation: a College of Pharmacy and Health Sciences, St. John's University , Queens , NY , USA.
authors.forename: Sri Varenya
authors.initials: SV
authors.lastname: Erukula
authors.affiliation: a College of Pharmacy and Health Sciences, St. John's University , Queens , NY , USA.
authors.forename: Yochana
authors.initials: Y
authors.lastname: Srivari
authors.affiliation: a College of Pharmacy and Health Sciences, St. John's University , Queens , NY , USA.|b LILOware LLC , West Orange , NJ , USA.|c United States Army Medical Research Institute of Infectious Diseases (USAMRIID)/Clinical RM , Frederick , MD , USA.
authors.forename: Parnali
authors.initials: P
authors.lastname: Chatterjee
mesh_terms: D002220:Carbamazepine / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D045744:Cell Line, Tumor; D003692:Delayed-Action Preparations / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D006801:Humans; D053758:Nanoparticles / Q000737:chemistry*; D012709:Serum Albumin / Q000737:chemistry*
chemical_list: D003692:Delayed-Action Preparations; D012709:Serum Albumin; D002220:Carbamazepine
keywords: Carbamazepine; albumin; drug release; fluorescence spectroscopy; nanoparticles