title: FUNDUS AUTOFLUORESCENCE IN A SUBCLINICAL CASE OF BEST DISEASE.
abstract: OBJECTIVE
  To demonstrate the usefulness of fundus autofluorescence for diagnosing a subclinical case of Best disease.
  
  
  RESULTS
  We describe a 27-year-old white woman without central visual symptoms, visual acuity of 20/12 in both eyes, carrying the previously reported p.Tyr227Cys mutation in the BEST1 gene. Although electrooculography, microperimetry (MP-1), and spectral-domain optical coherence tomography did not reveal unequivocal pathology, fundus autofluorescence imaging allowed to clearly detect a phenotypic correlate of Best disease, namely small areas of significantly increased fundus autofluorescence signals.
  
  
  CONCLUSIONS
  This report suggests that in selected subclinical cases, fundus autofluorescence may be more sensitive than the MP-1 and spectral-domain optical coherence tomography in the detection of subclinical cases of BEST1-associated retinopathy.
authors.affiliation: Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland.
authors.forename: Etienne M
authors.initials: EM
authors.lastname: Schönbach
authors.forename: Hendrik P
authors.initials: HP
authors.lastname: Scholl
mesh_terms: D000328:Adult; D005260:Female; D005451:Fluorescein Angiography; D005654:Fundus Oculi; D006801:Humans; D012680:Sensitivity and Specificity; D057826:Vitelliform Macular Dystrophy / Q000175:diagnosis*