title: Relationship between physician and patient assessment of performance status and survival in a large cohort of patients with haematologic malignancies.
abstract: Few studies have investigated the relationship between physician and patient-assessed performance status (PS) in blood cancers.
  
  
  
  Retrospective analysis among 1418 patients with haematologic malignancies seen at Dana-Farber Cancer Institute between 2007 and 2014. We analysed physician-patient agreement of Eastern Cooperative Oncology Group PS using weighted κ-statistics and survival analysis.
  
  
  
  Mean age was 58.6 years and average follow-up was 38 months. Agreement in PS was fair/moderate (weighted κ=0.41, 95% CI 0.37-0.44). Physicians assigned a better functional status (lower score) than patients (mean 0.60 vs 0.81), particularly when patients were young and the disease was aggressive. Both scores independently predicted survival, but physician scores were more accurate. Disagreements in score were associated with poorer survival when physicians rated PS better than patients, and were modified by age, sex and severity of disease.
  
  
  
  Physician-patient disagreements in PS score are common and have prognostic significance.
authors.affiliation: University of Arizona College of Medicine, 1501N Campbell Avenue, Tucson, AZ 85724, USA.
authors.forename: Michael A
authors.initials: MA
authors.lastname: Liu
authors.affiliation: Department of Medicine, Division of Aging, Brigham and Women's Hospital, 1620 Tremont Street, Boston, MA 02120, USA.|Department of Medical Oncology, Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, MA 02215, USA.
authors.forename: Tammy
authors.initials: T
authors.lastname: Hshieh
authors.affiliation: Department of Medical Oncology, Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, MA 02215, USA.
authors.forename: Nolan
authors.initials: N
authors.lastname: Condron
authors.affiliation: Department of Medical Oncology, Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, MA 02215, USA.
authors.forename: Martha
authors.initials: M
authors.lastname: Wadleigh
authors.affiliation: Department of Medical Oncology, Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, MA 02215, USA.
authors.forename: Gregory A
authors.initials: GA
authors.lastname: Abel
authors.affiliation: Department of Medicine, Division of Aging, Brigham and Women's Hospital, 1620 Tremont Street, Boston, MA 02120, USA.|Department of Medical Oncology, Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, MA 02215, USA.|Geriatric Research Education and Clinical Center, VA Boston Medical Center, 150 S. Huntington Avenue, Boston, MA 02130, USA.
authors.forename: Jane A
authors.initials: JA
authors.lastname: Driver
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D059026:Diagnostic Self Evaluation; D005260:Female; D019337:Hematologic Neoplasms / Q000401:mortality / Q000523:psychology* / Q000628:therapy; D006801:Humans; D053208:Kaplan-Meier Estimate; D008017:Life Expectancy; D008297:Male; D008875:Middle Aged; D010361:Patients / Q000523:psychology*; D010820:Physicians / Q000523:psychology*; D011379:Prognosis; D016016:Proportional Hazards Models; D012189:Retrospective Studies; D012720:Severity of Illness Index; D063189:Symptom Assessment; D055815:Young Adult