title: Meeting Report: The Role of the Mobilome in Cancer.
abstract: Approximately half of the human genome consists of repetitive sequence attributed to the activities of mobile DNAs, including DNA transposons, RNA transposons, and endogenous retroviruses. Of these, only long interspersed elements (LINE-1 or L1) and sequences copied by LINE-1 remain mobile in our species today. Although cells restrict L1 activity by both transcriptional and posttranscriptional mechanisms, L1 derepression occurs in developmental and pathologic contexts, including many types of cancers. However, we have limited knowledge of the extent and consequences of L1 expression in premalignancies and cancer. Participants in this NIH strategic workshop considered key questions to enhance our understanding of mechanisms and roles the mobilome may play in cancer biology. Cancer Res; 76(15); 4316-9. ©2016 AACR.
authors.affiliation: McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland. Medical Scientist Training Program, Johns Hopkins University School of Medicine, Baltimore, Maryland.
authors.forename: Daniel
authors.initials: D
authors.lastname: Ardeljan
authors.affiliation: Department of Pathology, Massachusetts General Hospital, Boston, Massachusetts.
authors.forename: Martin S
authors.initials: MS
authors.lastname: Taylor
authors.affiliation: McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland. Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland.
authors.forename: Kathleen H
authors.initials: KH
authors.lastname: Burns
authors.affiliation: Institute for Systems Genetics, New York University Langone Medical Center, New York, New York.
authors.forename: Jef D
authors.initials: JD
authors.lastname: Boeke
authors.affiliation: Division of Cancer Biology, NCI, NIH, Rockville, Maryland.
authors.forename: Michael Graham
authors.initials: MG
authors.lastname: Espey
authors.affiliation: Division of Cancer Biology, NCI, NIH, Rockville, Maryland. woodhousee@mail.nih.gov.
authors.forename: Elisa C
authors.initials: EC
authors.lastname: Woodhouse
authors.affiliation: Division of Cancer Biology, NCI, NIH, Rockville, Maryland.
authors.forename: Thomas Kevin
authors.initials: TK
authors.lastname: Howcroft
mesh_terms: D006801:Humans; D009369:Neoplasms / Q000235:genetics*; D018626:Retroelements / Q000235:genetics*
chemical_list: D018626:Retroelements