title: RETRACTED: The effects of tanshinone IIA on hypoxia/reoxygenation-induced myocardial microvascular endothelial cell apoptosis in rats via the JAK2/STAT3 signaling pathway.
abstract: This article has been retracted: please see Elsevier Policy on Article Withdrawal (http://www.elsevier.com/locate/withdrawalpolicy).
  
  This article has been retracted at the request of the Editor-in-Chief.
  
  An Expression of Concern for this article was previously published while an investigation was conducted (see related editorial: https://doi.org/10.1016/j.biopha.2022.113812). This retraction notice supersedes the Expression of Concern published earlier.
  
  Concern was raised about the reliability of the flow cytometry data shown in Figures 5, 7, and 8, which appears to contain similar repeating features, as detailed here: https://pubpeer.com/publications/B7A8CA625357F2A4DCEAC0E5AA276A; and here https://docs.google.com/spreadsheets/d/1r0MyIYpagBc58BRF9c3luWNlCX8VUvUuPyYYXzxWvgY/edit#gid=262337249. Independent analysis confirmed these findings and also identified additional suspected image duplications within the β-actin bands in Figure 9A, and between the Bcl-2 and Bax-2 Western blots in Figure 10A. The journal requested the corresponding author comment on these concerns and provide the associated raw data. The authors did not respond to this request and therefore the Editor-in-Chief decided to retract the article.
authors.affiliation: Cardiovascular Surgery, PLA Army General Hospital, Chinese People's Liberation Army, Beijing 100700, PR China.
authors.forename: Zhen-Tian
authors.initials: ZT
authors.lastname: Cui
authors.affiliation: Navy Technical Investigation Bureau Health Team, Chinese People's Liberation Army, Beijing 100700, PR China.
authors.forename: Jian-Ping
authors.initials: JP
authors.lastname: Liu
authors.affiliation: Institute of Cardiovascular Diseases, PLA Army General Hospital, Chinese People's Liberation Army, Beijing 100700, PR China. Electronic address: Wanlin_16@163.com.
authors.forename: Wan-Lin
authors.initials: WL
authors.lastname: Wei
mesh_terms: D045784:Abietanes / Q000494:pharmacology*; D000818:Animals; D017209:Apoptosis / Q000187:drug effects*; D015153:Blotting, Western; D002453:Cell Cycle / Q000187:drug effects; D015687:Cell Hypoxia / Q000187:drug effects; D048430:Cell Shape / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D042783:Endothelial Cells / Q000187:drug effects / Q000378:metabolism / Q000473:pathology*; D005786:Gene Expression Regulation / Q000187:drug effects; D020287:In Situ Nick-End Labeling; D053614:Janus Kinase 2 / Q000378:metabolism; D053078:Membrane Potential, Mitochondrial / Q000187:drug effects; D055806:Microvessels / Q000473:pathology*; D009206:Myocardium / Q000473:pathology*; D010100:Oxygen / Q000494:pharmacology*; D020011:Protective Agents / Q000494:pharmacology; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D017207:Rats, Sprague-Dawley; D017382:Reactive Oxygen Species / Q000378:metabolism; D050796:STAT3 Transcription Factor / Q000378:metabolism; D015398:Signal Transduction / Q000187:drug effects*
chemical_list: D045784:Abietanes; D020011:Protective Agents; D012333:RNA, Messenger; D017382:Reactive Oxygen Species; D050796:STAT3 Transcription Factor; C021751:tanshinone; D053614:Janus Kinase 2; D010100:Oxygen
keywords: Apoptosis; Cell cycle; Hypoxia/reoxygenation; JAK2/STAT3; Myocardial microvascular endothelial cell; Primary culture; Tanshinone IIA; Tri-gas incubator