title: Open-Label Study of Absorption and Clearance of 1% Voriconazole Eye Drops.
abstract: Twenty participants undergoing elective cataract surgery received 1% voriconazole eye drops (1 drop per eye) either 20, 40, 60, or 80 min before surgery. Median voriconazole concentrations of 1.9 to 3.2 mg/liter in aqueous humor samples were attained over the first 80 min, which were higher than in vitro MIC90values for typical fungi that cause keratitis.
authors.affiliation: Collaborative Drug Discovery Research (CDDR) Group, Faculty of Pharmacy, Universiti Teknologi MARA, Puncak Alam, Selangor, Malaysia.|Centre for Medicine Use and Safety, Faculty of Pharmacy and Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia.
authors.forename: Chin Fen
authors.initials: CF
authors.lastname: Neoh
authors.affiliation: Department of Pharmacy, Royal Victorian Eye and Ear Hospital (RVEEH), East Melbourne, Victoria, Australia.
authors.forename: Lok
authors.initials: L
authors.lastname: Leung
authors.affiliation: Corneal Unit, Royal Victorian Eye and Ear Hospital (RVEEH), Centre for Eye Research Australia, East Melbourne, Victoria, Australia.
authors.forename: Elsie
authors.initials: E
authors.lastname: Chan
authors.affiliation: College of Pharmacy, Qatar University, Doha, Qatar.
authors.forename: Daoud
authors.initials: D
authors.lastname: Al-Badriyeh
authors.affiliation: Special Chemistry, Melbourne Health Pathology, The Royal Melbourne Hospital, Parkville, Victoria, Australia.
authors.forename: Robert O
authors.initials: RO
authors.lastname: Fullinfaw
authors.affiliation: Corneal Unit, Royal Victorian Eye and Ear Hospital (RVEEH), Centre for Eye Research Australia, East Melbourne, Victoria, Australia.|Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong Eye Hospital, Kowloon, Hong Kong, China.
authors.forename: Vishal
authors.initials: V
authors.lastname: Jhanji
authors.affiliation: Corneal Unit, Royal Victorian Eye and Ear Hospital (RVEEH), Centre for Eye Research Australia, East Melbourne, Victoria, Australia.
authors.forename: Rasik B
authors.initials: RB
authors.lastname: Vajpayee
authors.affiliation: Department of Pharmacy, Royal Victorian Eye and Ear Hospital (RVEEH), East Melbourne, Victoria, Australia.|Health Systems Program Office, Integrated Soldier Systems Branch, Land Systems Division, Capability Acquisition and Sustainment Group, Department of Defence, Victoria Barracks Melbourne, Southbank, Victoria, Australia.
authors.forename: Geoffrey E
authors.initials: GE
authors.lastname: Davies
authors.affiliation: Centre for Medicine Use and Safety, Faculty of Pharmacy and Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia.
authors.forename: Kay
authors.initials: K
authors.lastname: Stewart
authors.affiliation: Centre for Medicine Use and Safety, Faculty of Pharmacy and Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia david.kong@monash.edu.
authors.forename: David C M
authors.initials: DC
authors.lastname: Kong
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000935:Antifungal Agents / Q000493:pharmacokinetics; D001082:Aqueous Humor / Q000187:drug effects*; D002387:Cataract Extraction; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009883:Ophthalmic Solutions / Q000493:pharmacokinetics*; D065819:Voriconazole / Q000493:pharmacokinetics*
chemical_list: D000935:Antifungal Agents; D009883:Ophthalmic Solutions; D065819:Voriconazole