title: Kinetic Analysis of Benign and Malignant Breast Lesions With Ultrafast Dynamic Contrast-Enhanced MRI: Comparison With Standard Kinetic Assessment.
abstract: OBJECTIVE
  The purposes of this study were to evaluate diagnostic parameters measured with ultrafast MRI acquisition and with standard acquisition and to compare diagnostic utility for differentiating benign from malignant lesions.
  
  
  METHODS
  Ultrafast acquisition is a high-temporal-resolution (7 seconds) imaging technique for obtaining 3D whole-breast images. The dynamic contrast-enhanced 3-T MRI protocol consists of an unenhanced standard and an ultrafast acquisition that includes eight contrast-enhanced ultrafast images and four standard images. Retrospective assessment was performed for 60 patients with 33 malignant and 29 benign lesions. A computer-aided detection system was used to obtain initial enhancement rate and signal enhancement ratio (SER) by means of identification of a voxel showing the highest signal intensity in the first phase of standard imaging. From the same voxel, the enhancement rate at each time point of the ultrafast acquisition and the AUC of the kinetic curve from zero to each time point of ultrafast imaging were obtained.
  
  
  RESULTS
  There was a statistically significant difference between benign and malignant lesions in enhancement rate and kinetic AUC for ultrafast imaging and also in initial enhancement rate and SER for standard imaging. ROC analysis showed no significant differences between enhancement rate in ultrafast imaging and SER or initial enhancement rate in standard imaging.
  
  
  CONCLUSIONS
  Ultrafast imaging is useful for discriminating benign from malignant lesions. The differential utility of ultrafast imaging is comparable to that of standard kinetic assessment in a shorter study time.
authors.affiliation: 1 Department of Radiology, The University of Chicago, 5841 S Maryland Ave, MC2026, Chicago, IL 60637.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Abe
authors.affiliation: 2 Department of Diagnostic Radiology, Tohoku University Graduate School of Medicine, Sendai, Japan.
authors.forename: Naoko
authors.initials: N
authors.lastname: Mori
authors.affiliation: 1 Department of Radiology, The University of Chicago, 5841 S Maryland Ave, MC2026, Chicago, IL 60637.
authors.forename: Keiko
authors.initials: K
authors.lastname: Tsuchiya
authors.affiliation: 1 Department of Radiology, The University of Chicago, 5841 S Maryland Ave, MC2026, Chicago, IL 60637.
authors.forename: David V
authors.initials: DV
authors.lastname: Schacht
authors.affiliation: 1 Department of Radiology, The University of Chicago, 5841 S Maryland Ave, MC2026, Chicago, IL 60637.
authors.forename: Federico D
authors.initials: FD
authors.lastname: Pineda
authors.affiliation: 1 Department of Radiology, The University of Chicago, 5841 S Maryland Ave, MC2026, Chicago, IL 60637.
authors.forename: Yulei
authors.initials: Y
authors.lastname: Jiang
authors.affiliation: 1 Department of Radiology, The University of Chicago, 5841 S Maryland Ave, MC2026, Chicago, IL 60637.
authors.forename: Gregory S
authors.initials: GS
authors.lastname: Karczmar
mesh_terms: D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology*; D003287:Contrast Media / Q000493:pharmacokinetics; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D021621:Imaging, Three-Dimensional; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008536:Meglumine / Q000031:analogs & derivatives / Q000493:pharmacokinetics; D008875:Middle Aged; D009942:Organometallic Compounds / Q000493:pharmacokinetics; D012189:Retrospective Studies
chemical_list: D003287:Contrast Media; D009942:Organometallic Compounds; C064572:gadobenic acid; D008536:Meglumine
keywords: MRI; breast; cancer; kinetics; ultrafast