title: Continuous Renal Replacement Therapy for Acute Renal Failure in Patients with Cancer: A Well-Tolerated Adjunct Treatment.
abstract: BACKGROUND
  Acute renal failure (ARF) has a poor prognosis in patients with cancer requiring intensive care unit (ICU) admission. Our aim is finding prognostic factors for hospital mortality in patients with cancer with ARF requiring renal replacement therapy (RRT).
  
  
  METHODS
  In this retrospective study, all patients with cancer with ARF treated with continuous venovenous filtration (CVVHDF) in the ICU of the Institut Jules Bordet, between January 1, 2003 and December 31, 2012, were included.
  
  
  RESULTS
  One hundred and three patients are assessed: men/women 69/34, median age 62 years, solid/hematologic tumors 68/35, median SAPS II 56. Mortality rate was 63%. Seven patients required chronic renal dialysis. After multivariate analysis, two variables were statistically associated with hospital mortality: more than one organ failure (including kidney) (OR 5.918; 95% CI 2.184-16.038; p < 0.001) and low albumin level (OR 3.341; 95% CI 1.229-9.077; p = 0.02). Only minor complications related to CVVHDF have been documented.
  
  
  CONCLUSIONS
  Despite the poor prognosis associated with ARF, CVVHDF is an effective and tolerable renal replacement technique in patients with cancer admitted to the ICU. Multiple organ failure and hypoalbuminemia, two independent prognostic factors for hospital mortality have to be considered when deciding for introducing RRT.
authors.affiliation: Department of Intensive Care and Oncological Emergencies and Thoracic Oncology, Institut Jules Bordet, Université Libre de Bruxelles , Brussels , Belgium.
authors.forename: Rebecca
authors.initials: R
authors.lastname: Fischler
authors.affiliation: Department of Intensive Care and Oncological Emergencies and Thoracic Oncology, Institut Jules Bordet, Université Libre de Bruxelles , Brussels , Belgium.
authors.forename: Anne-Pascale
authors.initials: AP
authors.lastname: Meert
authors.affiliation: Department of Intensive Care and Oncological Emergencies and Thoracic Oncology, Institut Jules Bordet, Université Libre de Bruxelles , Brussels , Belgium.
authors.forename: Jean-Paul
authors.initials: JP
authors.lastname: Sculier
authors.affiliation: Department of Intensive Care and Oncological Emergencies and Thoracic Oncology, Institut Jules Bordet, Université Libre de Bruxelles , Brussels , Belgium.
authors.forename: Thierry
authors.initials: T
authors.lastname: Berghmans
keywords: acute kidney injury; intensive care; neoplasms; prognosis; renal dialysis