title: Intestinal manifestations of postnatal and congenital cytomegalovirus infection in term and preterm infants.
abstract: To review the relevant literature on cytomegalovirus-(CMV-)related intestinal problems in neonates, supplemented by two own cases of volvulus, a PubMed search and separate additional searches with characterizing terms were performed. 46 hits were found, 15 of which had to be excluded because they did not report clinical cases, yielding a total of 47 infants. Symptoms in both preterm and term infants with proven postnatal infection (n=16) included abdominal distension, bloody diarrhoea, necrotising enterocolitis (NEC) with perforation and intestinal stricture, with lethal outcome in 3 patients. Manifestations in congenital or unclearly allocated CMV-infections, including volvulus, were similar. We report on 2 additional cases with volvulus in extremely low gestational age neonates (ELGANs) with proven postnatal CMV-infection and concurrent detection of CMV positive cells within the resected intestinal stroma. As a conclusion volvulus should be added to other known intestinal manifestations of breastmilk (BM) related postnatal CMV disease in extremely preterm infants.
authors.affiliation: Dept. of Neonatology, University Childreńs Hospital, Tuebingen, Germany. Electronic address: Rangmar.Goelz@med.uni-tuebingen.de.
authors.forename: Rangmar
authors.initials: R
authors.lastname: Goelz
authors.affiliation: Institute of Medical Virology and Epidemiology of Viral Diseases, University Hospital, Tuebingen, Germany.
authors.forename: Klaus
authors.initials: K
authors.lastname: Hamprecht
authors.affiliation: Dept. of Molecular Pathology, University Hospital, Tuebingen, Germany.
authors.forename: Karin
authors.initials: K
authors.lastname: Klingel
authors.affiliation: Dept. of Neonatology, University Childreńs Hospital, Tuebingen, Germany.
authors.forename: Christian F
authors.initials: CF
authors.lastname: Poets
mesh_terms: D003586:Cytomegalovirus Infections / Q000150:complications / Q000151:congenital / Q000821:virology; D005865:Gestational Age; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007234:Infant, Premature; D007410:Intestinal Diseases; D045822:Intestinal Volvulus
keywords: Enteropathy; Postnatal CMV infection; Preterm; Review; Volvulus