title: Delayed tooth emergence in children infected with human immunodeficiency virus.
abstract: OBJECTIVE
  There is limited evidence that early deficits in growth might be reflected in tooth emergence in children infected with human immunodeficiency virus (HIV). The purpose of this study was to prospectively evaluate tooth emergence timing between children positive and negative for HIV in the exposed and unexposed groups, respectively.
  
  
  METHODS
  A longitudinal study of children positive for HIV and HIV-negative household peers, aged 2 to 15 years was conducted between 1993 and 1996. Emergence status was determined for the maxillary and the mandibular permanent first molars and the central and lateral incisors. A multivariable, discrete time, proportional hazards model was fitted to the data. Median age of emergence for each of the six pairs of teeth was calculated using the parameter estimates from the regression model.
  
  
  RESULTS
  A total of 116 participants (62 HIV positive, 54 HIV negative) completed six examinations over the 36-month study period. Statistical differences in tooth emergence timing were observed for five of the six tooth pairs, with children positive for HIV being less likely to have emergence of the corresponding tooth compared with the children negative for HIV. Age differences for each tooth pair ranged from 0.7 to 1.5 years, with a median emergence age difference of 1.03 years.
  
  
  CONCLUSIONS
  Delayed tooth emergence of the permanent dentition was observed in children with HIV.
authors.affiliation: Director of Dental Research, Department of Dental Medicine, NYU-Lutheran Medical Center, Brooklyn, NY, USA; and Associate Professor, University of Rochester, Eastman Institute for Oral Health, Rochester NY, USA. Electronic address: wp9@nyu.edu.
authors.forename: Walter J
authors.initials: WJ
authors.lastname: Psoter
authors.affiliation: Clinical Assistant Professor, Cariology and Comprehensive Care, New York University College of Dentistry, New York, USA.
authors.forename: Evelyn M
authors.initials: EM
authors.lastname: Nelson
authors.affiliation: Research Associate, Department of Pediatrics, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
authors.forename: Kevin J
authors.initials: KJ
authors.lastname: Psoter
authors.affiliation: Assistant Research Professor, Epidemiology and Health Promotion, New York University College of Dentistry, New York, USA.
authors.forename: Bianca A
authors.initials: BA
authors.lastname: Dearing
authors.affiliation: Professor, Department of Epidemiology & Health Promotion, New York University College of Dentistry, New York, USA.
authors.forename: Ralph V
authors.initials: RV
authors.lastname: Katz
authors.affiliation: Professor, Department of Community Dentistry and Behavioral Science, University of Florida College of Dentistry, Gainesville, FL, USA.
authors.forename: Frank
authors.initials: F
authors.lastname: Catalanotto
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D019229:Dentition, Permanent; D005260:Female; D015658:HIV Infections / Q000150:complications*; D006801:Humans; D007223:Infant; D008137:Longitudinal Studies; D008297:Male; D011446:Prospective Studies; D014078:Tooth Eruption