title: Targeted nanoparticles for colorectal cancer.
abstract: Colorectal cancer (CRC) is highly prevalent worldwide, and despite notable progress in treatment still leads to significant morbidity and mortality. The use of nanoparticles as a drug delivery system has become one of the most promising strategies for cancer therapy. Targeted nanoparticles could take advantage of differentially expressed molecules on the surface of tumor cells, providing effective release of cytotoxic drugs. Several efforts have recently reported the use of diverse molecules as ligands on the surface of nanoparticles to interact with the tumor cells, enabling the effective delivery of antitumor agents. Here, we present recent advances in targeted nanoparticles against CRC and discuss the promising use of ligands and cellular targets in potential strategies for the treatment of CRCs.
authors.affiliation: Laboratory of Nanomedicine & Targeted Delivery, Center for Integrative Medicine & Innovative Science, Faculty of Medicine, & Center for Bioinformatics & Integrative Biology, Faculty of Biological Sciences, Universidad Andres Bello, Santiago, 8370071 Santiago, Chile.
authors.forename: Bruno A
authors.initials: BA
authors.lastname: Cisterna
authors.affiliation: Laboratory of Nanomedicine & Biomaterials, Harvard Medical School, Department of Anesthesiology, Brigham & Women's Hospital, Boston, MA 02115, USA.|Department of Micro & Nanotechnology, Technical University of Denmark, DTU Nanotech, 2800 Kgs. Lyngby, Denmark.
authors.forename: Nazila
authors.initials: N
authors.lastname: Kamaly
authors.affiliation: Laboratory of Nanomedicine & Biomaterials, Harvard Medical School, Department of Anesthesiology, Brigham & Women's Hospital, Boston, MA 02115, USA.|Center for Convergence Bioceramic Materials, Convergence R&D Division, Korea Institute of Ceramic Engineering & Technology, 101, Soho-ro, Jinju-si, Gyeongsangnam-do 52851, Republic of Korea.
authors.forename: Won Il
authors.initials: WI
authors.lastname: Choi
authors.affiliation: Department of Surgery, Brigham & Women's Hospital, Boston, MA 02115, USA.
authors.forename: Ali
authors.initials: A
authors.lastname: Tavakkoli
authors.affiliation: Laboratory of Nanomedicine & Biomaterials, Harvard Medical School, Department of Anesthesiology, Brigham & Women's Hospital, Boston, MA 02115, USA.|King Abdulaziz University, Jeddah 21589, Saudi Arabia.
authors.forename: Omid C
authors.initials: OC
authors.lastname: Farokhzad
authors.affiliation: Laboratory of Nanomedicine & Targeted Delivery, Center for Integrative Medicine & Innovative Science, Faculty of Medicine, & Center for Bioinformatics & Integrative Biology, Faculty of Biological Sciences, Universidad Andres Bello, Santiago, 8370071 Santiago, Chile.|Laboratory of Nanomedicine & Biomaterials, Harvard Medical School, Department of Anesthesiology, Brigham & Women's Hospital, Boston, MA 02115, USA.|Center for the Development of Nanoscience & Nanotechnology, CEDENNA, 9170124 Santiago, Chile.
authors.forename: Cristian
authors.initials: C
authors.lastname: Vilos
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000627:therapeutic use*; D015179:Colorectal Neoplasms / Q000188:drug therapy*; D016503:Drug Delivery Systems; D006801:Humans; D058990:Molecular Targeted Therapy; D053758:Nanoparticles / Q000737:chemistry / Q000627:therapeutic use*
chemical_list: D000970:Antineoplastic Agents
keywords: cancer therapy; colorectal cancer (CRC); controlled release; drug delivery; targeted nanoparticles