title: Nuclear autophagy: An evolutionarily conserved mechanism of nuclear degradation in the cytoplasm.
abstract: Macroautophagy/autophagy is a catabolic process that is essential for cellular homeostasis. Studies on autophagic degradation of cytoplasmic components have generated interest in nuclear autophagy. Although its mechanisms and roles have remained elusive, tremendous progress has been made toward understanding nuclear autophagy. Nuclear autophagy is evolutionarily conserved in eukaryotes that may target various nuclear components through a series of processes, including nuclear sensing, nuclear export, autophagic substrate encapsulation and autophagic degradation in the cytoplasm. However, the molecular processes and regulatory mechanisms involved in nuclear autophagy remain largely unknown. Numerous studies have highlighted the importance of nuclear autophagy in physiological and pathological processes such as cancer. This review focuses on current advances in nuclear autophagy and provides a summary of its research history and landmark discoveries to offer new perspectives.
authors.affiliation: a Hubei Key Laboratory of Cell Homeostasis, Laboratory of Molecular and Developmental Genetics, College of Life Sciences , Wuhan University , Wuhan , China.
authors.forename: Majing
authors.initials: M
authors.lastname: Luo
authors.affiliation: a Hubei Key Laboratory of Cell Homeostasis, Laboratory of Molecular and Developmental Genetics, College of Life Sciences , Wuhan University , Wuhan , China.
authors.forename: Xueya
authors.initials: X
authors.lastname: Zhao
authors.affiliation: a Hubei Key Laboratory of Cell Homeostasis, Laboratory of Molecular and Developmental Genetics, College of Life Sciences , Wuhan University , Wuhan , China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Song
authors.affiliation: a Hubei Key Laboratory of Cell Homeostasis, Laboratory of Molecular and Developmental Genetics, College of Life Sciences , Wuhan University , Wuhan , China.
authors.forename: Hanhua
authors.initials: H
authors.lastname: Cheng
authors.affiliation: a Hubei Key Laboratory of Cell Homeostasis, Laboratory of Molecular and Developmental Genetics, College of Life Sciences , Wuhan University , Wuhan , China.
authors.forename: Rongjia
authors.initials: R
authors.lastname: Zhou
mesh_terms: D000818:Animals; D001343:Autophagy; D005075:Biological Evolution; D002467:Cell Nucleus / Q000378:metabolism*; D006801:Humans; D008954:Models, Biological; D009685:Nuclear Envelope / Q000378:metabolism; D012441:Saccharomyces cerevisiae / Q000166:cytology / Q000378:metabolism
keywords: autophagy; degradation; evolution; nuclear components; nucleus