title: The First Identification and Complete Genome of Senecavirus A Affecting Pig with Idiopathic Vesicular Disease in China.
abstract: Senecavirus A (SVA) infection was recently confirmed in pigs in Brazil. In March, 2015, an outbreak of vesicular disease occurred in Guangdong, China, characterized by vesicular lesions in sows and acute death of neonatal piglets. Cumulative incidence of porcine idiopathic vesicular disease in farm A was 258, which had a total number of 5500 sows. Sows in farm B displayed typical vesicular symptoms by May, 2015, which also had 5500 sows. A total of 278 and 142 of 5500 sows in farm B demonstrated lame and presented vesicles, respectively, associated with a total of 186 mortality in piglets. Routine differential diagnoses for swine vesicular disease were carried out to exclude infection with foot-and-mouth disease virus, swine vesicular disease virus, vesicular exanthema of swine virus and vesicular stomatitis virus. In this study, seven pairs of primer were designed to amplify the complete genome of SVA in RT-PCR assays. Sequence alignment showed that this Chinese strain shares 94.4-97.1% sequence identity to other eight strains of SVA. This is the first report of SVA in China and provides information about the association between SVA infection and vesicular disease.
authors.affiliation: College of Animal Science, South China Agricultural University, Guangzhou, China.
authors.forename: Q
authors.initials: Q
authors.lastname: Wu
authors.affiliation: College of Animal Science, South China Agricultural University, Guangzhou, China.
authors.forename: X
authors.initials: X
authors.lastname: Zhao
authors.affiliation: College of Animal Science, South China Agricultural University, Guangzhou, China.
authors.forename: Y
authors.initials: Y
authors.lastname: Bai
authors.affiliation: College of Animal Science, South China Agricultural University, Guangzhou, China.
authors.forename: B
authors.initials: B
authors.lastname: Sun
authors.affiliation: College of Animal Science, South China Agricultural University, Guangzhou, China.
authors.forename: Q
authors.initials: Q
authors.lastname: Xie
authors.affiliation: College of Animal Science, South China Agricultural University, Guangzhou, China.
authors.forename: J
authors.initials: J
authors.lastname: Ma
mesh_terms: D000818:Animals; D002681:China / Q000453:epidemiology; D004196:Disease Outbreaks / Q000662:veterinary; D010849:Picornaviridae / Q000235:genetics* / Q000302:isolation & purification; D010850:Picornaviridae Infections / Q000662:veterinary* / Q000821:virology; D013552:Swine; D013553:Swine Diseases / Q000453:epidemiology; D013555:Swine Vesicular Disease / Q000453:epidemiology / Q000821:virology*
keywords: 
  Senecavirus A
  ; first identification in China; genome; outbreak of vesicular disease; swine vesicular disease