title: First reported case of intraventricular tigecycline for meningitis from extremely drug-resistant Acinetobacter baumannii.
abstract: The authors report on the first case of the intraventricular administration of tigecycline described in the Western literature. A 22-year-old man developed cerebrospinal fluid infection from an extremely drug-resistant strain of Acinetobacter baumannii as a complication of endoscopic transsphenoidal surgery for the removal of a giant pituitary adenoma. The patient was safely and successfully treated with the prolonged intraventricular administration of tigecycline. Here, the authors provide the schedule details that can be invaluable in treating meningitis from extremely drug-resistant bacterial strains. Intraventricular tigecycline can be a valuable tool against multidrug-resistant central nervous system infections.
authors.affiliation: Institutes of 1 Neurosurgery.
authors.forename: Liverana
authors.initials: L
authors.lastname: Lauretti
authors.affiliation: Institutes of 1 Neurosurgery.
authors.forename: Quintino Giorgio
authors.initials: QG
authors.lastname: D'Alessandris
authors.affiliation: Infectious Diseases, and.
authors.forename: Massimo
authors.initials: M
authors.lastname: Fantoni
authors.affiliation: Microbiology, Università Cattolica del Sacro Cuore, Rome, Italy.
authors.forename: Tiziana
authors.initials: T
authors.lastname: D'Inzeo
authors.affiliation: Institutes of 1 Neurosurgery.
authors.forename: Eduardo
authors.initials: E
authors.lastname: Fernandez
authors.affiliation: Institutes of 1 Neurosurgery.
authors.forename: Roberto
authors.initials: R
authors.lastname: Pallini
authors.affiliation: Infectious Diseases, and.
authors.forename: Giancarlo
authors.initials: G
authors.lastname: Scoppettuolo
mesh_terms: D000151:Acinetobacter Infections / Q000188:drug therapy*; D040981:Acinetobacter baumannii / Q000187:drug effects; D000900:Anti-Bacterial Agents / Q000008:administration & dosage* / Q000494:pharmacology; D024881:Drug Resistance, Bacterial; D006801:Humans; D007276:Injections, Intraventricular; D008297:Male; D016920:Meningitis, Bacterial / Q000188:drug therapy* / Q000382:microbiology; D000078304:Tigecycline / Q000008:administration & dosage*; D055815:Young Adult
chemical_list: D000900:Anti-Bacterial Agents; D000078304:Tigecycline
keywords: Acinetobacter; CNS = central nervous system; CSF = cerebrospinal fluid; IV = intravenous; IVT = intraventricular; MDR = multidrug resistant; XDR = extremely drug resistant; infection; intraventricular therapy; meningitis; tigecycline; transsphenoidal surgery