title: Chemokine-Like Receptor 1 mRNA Weakly Correlates with Non-Alcoholic Steatohepatitis Score in Male but Not Female Individuals.
abstract: The chemokine-like receptor 1 (CMKLR1) ligands resolvin E1 and chemerin are known to modulate inflammatory response. The progression of non-alcoholic fatty liver disease (NAFLD) to non-alcoholic steatohepatitis (NASH) is associated with inflammation. Here it was analyzed whether hepatic CMKLR1 expression is related to histological features of NASH. Therefore, CMKLR1 mRNA was quantified in liver tissue of 33 patients without NAFLD, 47 patients with borderline NASH and 38 patients with NASH. Hepatic CMKLR1 mRNA was not associated with gender and body mass index (BMI) in the controls and the whole study group. CMKLR1 expression was similar in controls and in patients with borderline NASH and NASH. In male patients weak positive correlations with inflammation, fibrosis and NASH score were identified. In females CMKLR1 was not associated with features of NAFLD. Liver CMKLR1 mRNA tended to be higher in type 2 diabetes patients of both genders and in hypercholesterolemic women. In summary, this study shows that hepatic CMKLR1 mRNA is weakly associated with features of NASH in male patients only.
authors.affiliation: Department of Internal Medicine I, Regensburg University Hospital, 93053 Regensburg, Germany. maximilian.neumann@stud.uni-regensburg.de.
authors.forename: Maximilian
authors.initials: M
authors.lastname: Neumann
authors.affiliation: Department of Internal Medicine I, Regensburg University Hospital, 93053 Regensburg, Germany. elisabeth.meier@klinik.uni-regensburg.de.
authors.forename: Elisabeth M
authors.initials: EM
authors.lastname: Meier
authors.affiliation: Department of Internal Medicine I, Regensburg University Hospital, 93053 Regensburg, Germany. lisa.rein-fischboeck@klinik.uni-regensburg.de.
authors.forename: Lisa
authors.initials: L
authors.lastname: Rein-Fischboeck
authors.affiliation: Department of Internal Medicine I, Regensburg University Hospital, 93053 Regensburg, Germany. sabrina.krautbauer@klinik.uni-regensburg.de.
authors.forename: Sabrina
authors.initials: S
authors.lastname: Krautbauer
authors.affiliation: Department of Internal Medicine I, Regensburg University Hospital, 93053 Regensburg, Germany. kristina.eisinger@gmx.de.
authors.forename: Kristina
authors.initials: K
authors.lastname: Eisinger
authors.affiliation: Institute of Clinical Chemistry and Laboratory Medicine, Regensburg University Hospital, 93053 Regensburg, Germany. charalampos.aslanidis@klinik.uni-regensburg.de.
authors.forename: Charalampos
authors.initials: C
authors.lastname: Aslanidis
authors.affiliation: Department of Internal Medicine I, Regensburg University Hospital, 93053 Regensburg, Germany. rebekka.pohl@klinik.uni-regensburg.de.
authors.forename: Rebekka
authors.initials: R
authors.lastname: Pohl
authors.affiliation: Children's University Hospital (KUNO), Regensburg University Hospital, 93053 Regensburg, Germany. thomas.weiss@klinik.uni-regensburg.de.
authors.forename: Thomas S
authors.initials: TS
authors.lastname: Weiss
authors.affiliation: Department of Internal Medicine I, Regensburg University Hospital, 93053 Regensburg, Germany. christa.buechler@klinik.uni-regensburg.de.
authors.forename: Christa
authors.initials: C
authors.lastname: Buechler
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015992:Body Mass Index; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics; D018450:Disease Progression; D005260:Female; D006801:Humans; D008099:Liver / Q000378:metabolism / Q000473:pathology; D008297:Male; D008875:Middle Aged; D065626:Non-alcoholic Fatty Liver Disease / Q000235:genetics*; D012333:RNA, Messenger / Q000235:genetics*; D019707:Receptors, Chemokine / Q000235:genetics*; D012737:Sex Factors; D055815:Young Adult
chemical_list: C102741:CMKLR1 protein, human; D012333:RNA, Messenger; D019707:Receptors, Chemokine
keywords: fibrosis; gender; liver steatosis; type 2 diabetes