title: MYO9B gene polymorphisms are associated with the risk of inflammatory bowel diseases.
abstract: Myosin IXB (MYO9B) gene polymorphisms have been extensively investigated in terms of their associations with inflammatory bowel disease (IBD), with contradictory results. The aim of this meta-analysis was to evaluate associations between MY09B gene polymorphisms and the risk of IBD, Crohn's disease (CD) and ulcerative colitis (UC). Eligible studies from PubMed, Embase, and CNKI databases were identified. Pooled odds ratios (ORs) and 95% confidence intervals (95% CIs) were calculated. Ten studies published in eight papers reporting 8,975 cases and 9,482 controls were included in this meta-analysis. Five MY09B gene polymorphisms were evaluated: rs1545620, rs962917, rs1457092, rs2305764, and rs2305767. Our data suggested that the rs1545620 polymorphism was associated with a decreased risk of IBD. A similar result was found for rs2305767 and UC. The rs962917 single nucleotide polymorphism (SNP) increased the risk of IBD, CD and UC. Moreover, rs1457092 increased the risk of IBD and UC. Rs2305764 was also associated with an increased risk of IBD. Furthermore, stratification analyses indicated that rs1545620 decreased the risk of IBD, while rs962917 increased the risk of IBD, CD and UC in Caucasian populations. To sum up, our data indicate that these five SNPs in MY09B are significantly associated with the risk of IBD.
authors.affiliation: Department of Orthopedics, Affiliated Hospital of Nanjing Medical University, Changzhou Second People's Hospital, Changzhou, China.
authors.forename: Ming-Jie
authors.initials: MJ
authors.lastname: Wang
authors.affiliation: Liver Surgery of Jiangsu Province People's Hospital, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
authors.forename: Xiao-Liang
authors.initials: XL
authors.lastname: Xu
authors.affiliation: Department of Thoracic Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
authors.forename: Guo-Liang
authors.initials: GL
authors.lastname: Yao
authors.affiliation: Department of General Surgery, Affiliated Hospital of Nanjing Medical University, Changzhou Second People's Hospital, Changzhou, China.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Yu
authors.affiliation: Department of General Surgery, Affiliated Hospital of Nanjing Medical University, Changzhou Second People's Hospital, Changzhou, China.
authors.forename: Chun-Fu
authors.initials: CF
authors.lastname: Zhu
authors.affiliation: Department of General Surgery, Affiliated Hospital of Nanjing Medical University, Changzhou Second People's Hospital, Changzhou, China.
authors.forename: Zhi-Jun
authors.initials: ZJ
authors.lastname: Kong
authors.affiliation: Department of General Surgery, Wuxi Third People's Hospital, Wuxi, China.
authors.forename: Hui
authors.initials: H
authors.lastname: Zhao
authors.affiliation: Department of General Surgery, Affiliated Hospital of Nanjing Medical University, Changzhou Second People's Hospital, Changzhou, China.
authors.forename: Li-Ming
authors.initials: LM
authors.lastname: Tang
authors.affiliation: Department of General Surgery, Affiliated Hospital of Nanjing Medical University, Changzhou Second People's Hospital, Changzhou, China.
authors.forename: Xi-Hu
authors.initials: XH
authors.lastname: Qin
mesh_terms: D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000453:epidemiology / Q000235:genetics*; D009218:Myosins / Q000235:genetics*; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D012306:Risk; D044465:White People
chemical_list: C113469:myosin IXB; D009218:Myosins
keywords: Crohn’s disease; Immune response; Immunity; Immunology and Microbiology Section; MYO9B; inflammatory bowel disease; polymorphism; ulcerative colitis