title: Influence of New Modified Biliopancreatic Diversion on Blood Glucose and Lipids in GK rats.
abstract: This study aimed to investigate the influence of new biliopancreatic diversion (NBPD) and duodenal-jejunal bypass (DJB) surgery on blood glucose, lipids, gastrointestinal hormones, and insulin in Goto-Kakizaki (GK) rats, an animal model for type 2 diabetes, in order to elucidate the mechanisms underlying the therapeutic effect of these types of surgery on this clinical condition.
  
  
  
  Thirty 30 male GK rats (SPF) aged 12 weeks were randomly assigned into three groups (n = 10 per group): sham group, NBPD group, and DJB group. Body weight, random plasma glucose, fasting plasma glucose (FPG), oral glucose tolerance (OGT), blood lipids, plasma insulin, glucagon like peptide-1 (GLP-1), and gastric inhibitory polypeptide (GIP) were measured before and after surgery.
  
  
  
  NBPD surgery improved glucose tolerance, decreased fasting free fatty acids, triglycerides, and cholesterol. It also increased fasting and postprandial GIP, but caused no change in GLP-1. DJB surgery produced results similar to NBPD surgery except for causing a decrease in postprandial GLP-1 and insulin, and a larger increase in fasting GIP.
  
  
  
  Moving the biliopancreatic duct outlet to the mid-jejunum (NBPD surgery) improves glucose tolerance and increases GIP, but does not change GLP-1. Adding duodenal bypass (DJB surgery) increases fasting GIP and decreases postprandial GLP-1.
authors.affiliation: Hepatopancreatobiliary Surgery Department, the First Affiliated Hospital of Fujian Medical University, No 20 Chazhong Road, Fuzhou City, Fujian, People's Republic of China. shangeng@sina.com.
authors.forename: Shangeng
authors.initials: S
authors.lastname: Weng
authors.affiliation: Hepatopancreatobiliary Surgery Department, the First Affiliated Hospital of Fujian Medical University, No 20 Chazhong Road, Fuzhou City, Fujian, People's Republic of China.
authors.forename: Bin
authors.initials: B
authors.lastname: Zhang
authors.affiliation: Hepatopancreatobiliary Surgery Department, the First Affiliated Hospital of Fujian Medical University, No 20 Chazhong Road, Fuzhou City, Fujian, People's Republic of China.
authors.forename: Changguo
authors.initials: C
authors.lastname: Xu
authors.affiliation: Hepatopancreatobiliary Surgery Department, the First Affiliated Hospital of Fujian Medical University, No 20 Chazhong Road, Fuzhou City, Fujian, People's Republic of China.
authors.forename: Su
authors.initials: S
authors.lastname: Feng
authors.affiliation: Hepatopancreatobiliary Surgery Department, the First Affiliated Hospital of Fujian Medical University, No 20 Chazhong Road, Fuzhou City, Fujian, People's Republic of China.
authors.forename: Hongxing
authors.initials: H
authors.lastname: He
mesh_terms: D000818:Animals; D015904:Biliopancreatic Diversion / Q000379:methods*; D001786:Blood Glucose / Q000032:analysis / Q000378:metabolism*; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000601:surgery*; D003924:Diabetes Mellitus, Type 2 / Q000601:surgery*; D004386:Duodenum / Q000601:surgery; D015390:Gastric Bypass / Q000379:methods; D005749:Gastric Inhibitory Polypeptide / Q000097:blood; D052216:Glucagon-Like Peptide 1 / Q000097:blood; D005951:Glucose Tolerance Test; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D007583:Jejunum / Q000601:surgery; D050356:Lipid Metabolism / Q000502:physiology; D008055:Lipids / Q000097:blood*; D008297:Male; D051381:Rats
chemical_list: D001786:Blood Glucose; D007328:Insulin; D008055:Lipids; D005749:Gastric Inhibitory Polypeptide; D052216:Glucagon-Like Peptide 1
keywords: Biliopancreatic juice; Duodenal-jejunal bypass; Goto-Kakizaki rat; Plasma glucose; Plasma lipid