title: Femtosecond Laser-Assisted Descemetorhexis: A Novel Technique in Descemet Membrane Endothelial Keratoplasty.
abstract: OBJECTIVE
  To explore the feasibility of femtosecond laser-assisted descemetorhexis (DR) to facilitate Descemet membrane endothelial keratoplasty (DMEK) surgery.
  
  
  METHODS
  Six pseudophakic patients suffering from Fuchs' endothelial dystrophy underwent femtosecond laser-assisted DMEK surgery. DR was performed using the LenSx femtosecond laser, followed by manual removal of the Descemet membrane. Optical coherence tomography images were used to measure DR parameters. Patients were followed up for 1 month to examine best corrected visual acuity, endothelial cell loss, flap detachment, and structure of the anterior chamber of the eye.
  
  
  RESULTS
  The diameter of the DR approximated the intended diameter closely [mean error of 34 μm (0.45%) and 54 μm (0.67%) in the x- and y-diameter, respectively] and did not require manual correction. The median visual acuity increased from 0.4 logMAR (range 0.6-0.4 logMAR) preoperative to 0.2 logMAR (range 0-0.4 logMAR) postoperative. The median endothelial cell loss was 22% (range 7%-34%). No clinically significant flap detachments were noted. All patients had clear corneas after surgery, and no side effects or damage to structures of the anterior chamber were noted.
  
  
  CONCLUSIONS
  Femtosecond laser-assisted DR is a safe and precise method for facilitating DMEK surgery.
authors.affiliation: Department of Ophthalmology, Charité-Medical University Berlin Campus Virchow Klinikum, Berlin, Germany.
authors.forename: Daniel
authors.initials: D
authors.lastname: Pilger
authors.forename: Christoph
authors.initials: C
authors.lastname: von Sonnleithner
authors.forename: Eckart
authors.initials: E
authors.lastname: Bertelmann
authors.forename: Antonia M
authors.initials: AM
authors.lastname: Joussen
authors.forename: Necip
authors.initials: N
authors.lastname: Torun
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000867:Anterior Chamber / Q000473:pathology; D002452:Cell Count; D055954:Corneal Endothelial Cell Loss / Q000175:diagnosis; D003886:Descemet Membrane / Q000601:surgery*; D057111:Descemet Stripping Endothelial Keratoplasty / Q000379:methods*; D004728:Endothelium, Corneal / Q000473:pathology; D005260:Female; D005500:Follow-Up Studies; D005642:Fuchs' Endothelial Dystrophy / Q000503:physiopathology / Q000601:surgery*; D006801:Humans; D053685:Laser Therapy / Q000379:methods*; D008297:Male; D008875:Middle Aged; D041623:Tomography, Optical Coherence; D014792:Visual Acuity / Q000502:physiology