title: Small Molecules for Psoriasis.
abstract: Acitretin is an older, oral, non-immunosuppressive medication for the treatment of psoriasis. Tofacitinib is an oral Janus kinase inhibitor that has been studied for use in psoriasis. Each offers efficacy in certain settings and patient types but carries substantial safety risks.
authors.affiliation: Clinical Professor of Dermatology Saint Louis University Central Dermatology St Louis, Missouri.
authors.forename: Craig L
authors.initials: CL
authors.lastname: Leonardi
mesh_terms: D017255:Acitretin / Q000008:administration & dosage* / Q000009:adverse effects; D000284:Administration, Oral; D003879:Dermatologic Agents / Q000008:administration & dosage* / Q000009:adverse effects; D019317:Evidence-Based Medicine; D006801:Humans; D011701:PUVA Therapy / Q000379:methods; D010880:Piperidines / Q000008:administration & dosage* / Q000009:adverse effects; D011565:Psoriasis / Q000188:drug therapy*; D011743:Pyrimidines / Q000008:administration & dosage* / Q000009:adverse effects; D011758:Pyrroles / Q000008:administration & dosage* / Q000009:adverse effects; D016896:Treatment Outcome
chemical_list: D003879:Dermatologic Agents; D010880:Piperidines; D011743:Pyrimidines; D011758:Pyrroles; C479163:tofacitinib; D017255:Acitretin
keywords: Acitretin; psoriasis; pustular psoriasis; tofacitinib; toxicity