title: Functional interactions between polypyrimidine tract binding protein and PRI peptide ligand containing proteins.
abstract: Polypyrimidine tract binding protein (PTBP1) is a heterogeneous nuclear ribonucleoprotein (hnRNP) that plays roles in most stages of the life-cycle of pre-mRNA and mRNAs in the nucleus and cytoplasm. PTBP1 has four RNA binding domains of the RNA recognition motif (RRM) family, each of which can bind to pyrimidine motifs. In addition, RRM2 can interact via its dorsal surface with proteins containing short peptide ligands known as PTB RRM2 interacting (PRI) motifs, originally found in the protein Raver1. Here we review our recent progress in understanding the interactions of PTB with RNA and with various proteins containing PRI ligands.
authors.affiliation: Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge CB2 1QW, U.K.
authors.forename: Miguel B
authors.initials: MB
authors.lastname: Coelho
authors.affiliation: Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge CB2 1QW, U.K.
authors.forename: David B
authors.initials: DB
authors.lastname: Ascher
authors.affiliation: Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge CB2 1QW, U.K.
authors.forename: Clare
authors.initials: C
authors.lastname: Gooding
authors.affiliation: Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge CB2 1QW, U.K.
authors.forename: Emma
authors.initials: E
authors.lastname: Lang
authors.affiliation: Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge CB2 1QW, U.K.
authors.forename: Hannah
authors.initials: H
authors.lastname: Maude
authors.affiliation: Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge CB2 1QW, U.K.
authors.forename: David
authors.initials: D
authors.lastname: Turner
authors.affiliation: Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge CB2 1QW, U.K.
authors.forename: Miriam
authors.initials: M
authors.lastname: Llorian
authors.affiliation: Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge CB2 1QW, U.K. Centro de Pesquisas René Rachou, Fundação Oswaldo Cruz, Avenida Augusto de Lima 1715, Belo Horizonte 30190-002, Brazil.
authors.forename: Douglas E V
authors.initials: DE
authors.lastname: Pires
authors.affiliation: Department of Molecular Neuroscience, UCL Institute of Neurology, Queen Square, London WC1N 3BG, U.K.
authors.forename: Jan
authors.initials: J
authors.lastname: Attig
authors.affiliation: Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge CB2 1QW, U.K. cwjs1@cam.ac.uk.
authors.forename: Christopher W J
authors.initials: CW
authors.lastname: Smith
mesh_terms: D001665:Binding Sites / Q000235:genetics; D002352:Carrier Proteins / Q000235:genetics / Q000378:metabolism; D034441:Heterogeneous-Nuclear Ribonucleoproteins / Q000235:genetics* / Q000378:metabolism; D006801:Humans; D008024:Ligands; D008957:Models, Genetic; D009687:Nuclear Proteins / Q000235:genetics / Q000378:metabolism; D010455:Peptides / Q000235:genetics / Q000378:metabolism; D038941:Polypyrimidine Tract-Binding Protein / Q000235:genetics* / Q000378:metabolism; D012322:RNA Precursors / Q000235:genetics* / Q000378:metabolism; D016601:RNA-Binding Proteins / Q000235:genetics* / Q000378:metabolism; D012261:Ribonucleoproteins
chemical_list: D002352:Carrier Proteins; D034441:Heterogeneous-Nuclear Ribonucleoproteins; D008024:Ligands; D009687:Nuclear Proteins; C450006:PTBP1 protein, human; D010455:Peptides; C486705:RAVER1 protein, human; D012322:RNA Precursors; D016601:RNA-Binding Proteins; D012261:Ribonucleoproteins; D038941:Polypyrimidine Tract-Binding Protein
keywords: Matrin3; PTB; RNA; alternative splicing; heterogeneous nuclear ribonucleoprotein (hnRNP); polypyrimidine tract binding protein