title: An Ir/Zn Dual Catalysis for Enantio- and Diastereodivergent α-Allylation of α-Hydroxyketones.
abstract: An Ir/Zn dual catalysis has been developed for the enantio- and diastereodivergent α-allylation of unprotected α-hydroxyketones under mild conditions, in the absence of any additional base. The cooperative action of a chiral iridium complex derived from phosphoramidites and a chiral Zn-ProPhenol complex is most likely responsible for its high reactivity, excellent enantioselectivity (up to >99% ee), and good diastereoselectivity (up to >20:1 dr). All four product stereoisomers could be prepared from the same set of starting materials and under identical conditions by simple selection of appropriate catalyst combinations.
authors.affiliation: School of Pharmacy and ‡School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University , Shanghai 200240, P. R. China.
authors.forename: Xiaohong
authors.initials: X
authors.lastname: Huo
authors.affiliation: School of Pharmacy and ‡School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University , Shanghai 200240, P. R. China.
authors.forename: Rui
authors.initials: R
authors.lastname: He
authors.affiliation: School of Pharmacy and ‡School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University , Shanghai 200240, P. R. China.
authors.forename: Xiao
authors.initials: X
authors.lastname: Zhang
authors.affiliation: School of Pharmacy and ‡School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University , Shanghai 200240, P. R. China.
authors.forename: Wanbin
authors.initials: W
authors.lastname: Zhang