title: Expressions of Endocan in Patients with Meningiomas and Gliomas.
abstract: Objective. Endocan has been shown to be a marker for several cancers and may show degree of malignancy. The aim of this study is to assess tissue levels of endocan in common brain tumors, namely, meningiomas, low-grade gliomas (LGGs), and high-grade gliomas (HGGs). Patients and Methods. Endocan was assayed by commercially available enzyme linked immunosorbent assay (ELISA) kits in a total of 50 brain tumors (20 meningiomas, 19 LGGs, and 20 HGGs) and 15 controls. The results were compared to control brain tissues. Results. Each tumor group showed significant higher levels of endocan compared to controls (p < 0.05). In addition, endocan levels showed steady increase from the least (meningiomas) to the most (HGGs) malignant tumors and positive correlation was noted between the degree of malignancy and endocan level (p = 0.0001). Conclusion. Endocan, a vital molecule for angiogenesis, is expressed in common brain tumors and results suggest that endocan could be a marker for malignancy.
authors.affiliation: Department of Biochemistry, Cerrahpasa Medical Faculty, Istanbul University, Istanbul, Turkey.
authors.forename: Pinar
authors.identifier: 0000-0001-8219-4205
authors.initials: P
authors.lastname: Atukeren
authors.affiliation: Department of Biochemistry, Cerrahpasa Medical Faculty, Istanbul University, Istanbul, Turkey.
authors.forename: Ahmad
authors.identifier: 0000-0003-2209-8187
authors.initials: A
authors.lastname: Kunbaz
authors.affiliation: Department of Neurosurgery, Samatya Training and Research Hospital, Istanbul, Turkey.
authors.forename: Okan
authors.initials: O
authors.lastname: Turk
authors.affiliation: Department of Neurosurgery, Cerrahpasa Medical Faculty, Istanbul University, Fatih, 34098 Istanbul, Turkey.
authors.forename: Rahsan
authors.identifier: 0000-0002-9947-3486
authors.initials: R
authors.lastname: Kemerdere
authors.affiliation: Department of Neurosurgery, Cerrahpasa Medical Faculty, Istanbul University, Fatih, 34098 Istanbul, Turkey.
authors.forename: Mustafa Onur
authors.identifier: 0000-0002-6256-0869
authors.initials: MO
authors.lastname: Ulu
authors.affiliation: Department of Forensic Medicine, Uludag University, Bursa, Turkey.
authors.forename: Nursel
authors.initials: N
authors.lastname: Turkmen Inanir
authors.affiliation: Department of Neurosurgery, Cerrahpasa Medical Faculty, Istanbul University, Fatih, 34098 Istanbul, Turkey.
authors.forename: Taner
authors.identifier: 0000-0002-1878-0696
authors.initials: T
authors.lastname: Tanriverdi
mesh_terms: D000328:Adult; D014408:Biomarkers, Tumor / Q000378:metabolism*; D001932:Brain Neoplasms / Q000378:metabolism* / Q000473:pathology; D016022:Case-Control Studies; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005500:Follow-Up Studies; D005910:Glioma / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D008297:Male; D008577:Meningeal Neoplasms / Q000378:metabolism* / Q000473:pathology; D008579:Meningioma / Q000378:metabolism* / Q000473:pathology; D009363:Neoplasm Proteins / Q000378:metabolism*; D009367:Neoplasm Staging; D011379:Prognosis; D011509:Proteoglycans / Q000378:metabolism*
chemical_list: D014408:Biomarkers, Tumor; C101134:ESM1 protein, human; D009363:Neoplasm Proteins; D011509:Proteoglycans