title: Clinical characteristics and prognostic factors of brain central neurocytoma.
abstract: OBJECTIVE
  This study is designed for the clinical characteristics and prognostic factors of central neurocytoma (CN).
  
  
  METHODS
  CN patients from 2004 to 2012 were enrolled from the Surveillance Epidemiology and End Results (SEER) data. Clinical characteristics including age, sex, race, tumor size, tumor number, surgery, and radiation therapy were summarized. Univariate and multivariate analysis were performed to explore the prognostic factors of CN.
  
  
  RESULTS
  CN tended to be borderline malignant and single lesion. Compared with other brain tumor (NCN), Patients with CN (CNs) were more likely to be female, young, and non-white race. Surgery was the primary treatment of CN. Univariate and Multivariate analysis indicated tumor number and surgery were both independent prognostic factors of CN (P < 0.05). Unifocal CNs had a lower mortality risk than multifocal ones (HR 0.167, 95% CI 0.052-0.537), surgery significantly reduced the death risk of CNs (HR 0.284, 95% CI 0.088-0.921).
  
  
  CONCLUSIONS
  CN tend to be borderline malignant, single lesion, operated on. Most CNs are female and younger. single lesion and surgery are the independent positive prognostic factors of CN.
authors.affiliation: Department of Radiation Oncology, Huai'an First People's Hospital, Nanjing Medical University, Huai'an, China.
authors.forename: Yaqi
authors.initials: Y
authors.lastname: Song
authors.affiliation: Department of Ophthalmology, Huai'an Second People's Hospital, Xuzhou Medical College, Huai'an, China.
authors.forename: Xinle
authors.initials: X
authors.lastname: Kang
authors.affiliation: Department of Internal Medicine, Huai'an Second People's Hospital, Xuzhou Medical College, Huai'an, China.
authors.forename: Gang
authors.initials: G
authors.lastname: Cao
authors.affiliation: Department of Oncology, HangZhou Hospital of ZheJiang Provincial Corps of Chinese People's Armed Police Force, HangZhou, China.
authors.forename: Yongqiang
authors.initials: Y
authors.lastname: Li
authors.affiliation: Department of Radiation Oncology, Huai'an First People's Hospital, Nanjing Medical University, Huai'an, China.
authors.forename: Xilei
authors.initials: X
authors.lastname: Zhou
authors.affiliation: Department of Radiation Oncology, Huai'an First People's Hospital, Nanjing Medical University, Huai'an, China.
authors.forename: Yusuo
authors.initials: Y
authors.lastname: Tong
authors.affiliation: Department of Radiation Oncology, Huai'an First People's Hospital, Nanjing Medical University, Huai'an, China.
authors.forename: Wanwei
authors.initials: W
authors.lastname: Wang
mesh_terms: D000328:Adult; D001932:Brain Neoplasms / Q000175:diagnosis* / Q000453:epidemiology / Q000401:mortality* / Q000628:therapy; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D018306:Neurocytoma / Q000175:diagnosis* / Q000453:epidemiology / Q000401:mortality* / Q000628:therapy; D011159:Population Surveillance; D011379:Prognosis; D016016:Proportional Hazards Models; D018426:SEER Program; D016019:Survival Analysis; D047368:Tumor Burden; D055815:Young Adult
keywords: SEER program; central neurocytoma; prognostic factors; surgery; tumor number