title: Association study of polymorphisms in the ABO gene with ischemic stroke in the Chinese population.
abstract: BACKGROUND
  Ischemic stroke is the main cause of mortality and disability in older people worldwide. Recently epidemiological studies indicate that ischemic stroke is a complex disorder with a strong genetic component. Genome-wide association studies (GWAS) identified several single nucleotide polymorphisms (SNPs) associated with coronary artery disease (CAD) and myocardial infarction (MI) locus in ABO gene. Our study examined the association between four variants in the ABO gene and the risk of ischemic stroke and its subtypes, large-artery atherosclerosis (LAA) and small-vessel diseases (SVD) in the Chinese population.
  
  
  METHODS
  In this case-control study, we recruited 1897 subjects, including 979 healthy controls and 918 ischemic stroke patients (465 with LAA and 453 with SVD). We selected four single nucleotide polymorphisms (rs579459, rs651007, rs514659 and rs529565) of the ABO gene and performed genotyping assays to assess the association with ischemic stroke and its subtypes.
  
  
  RESULTS
  We found three polymorphisms, rs579459 and rs651007 were significantly associated with LAA using additive model and rs529565 was significantly associated with LAA using additive and dominant models. And we failed to find any significant association between these SNPs and ischemic stroke and SVD in the Chinese population. However, after the Bonferroni correction for multiple comparisons, the P-values of these SNPs failed to exceed significant threshold under any models.
  
  
  CONCLUSIONS
  Our findings indicated that genetic variations of ABO gene may contribute to susceptibility of LAA but not ischemic stroke and SVD in the Chinese population. Our preliminary results should be further validated in prospective independent studies with expanded sample size.
authors.affiliation: Fuzhou General Hospital of Nanjing Military Command, Fuzhou, 350025, China.
authors.forename: Xiaoming
authors.initials: X
authors.lastname: Ling
authors.affiliation: The Health Management Institute of the General Hospital of PLA, Beijing, 100853, China.
authors.forename: Yansong
authors.initials: Y
authors.lastname: Zheng
authors.affiliation: College of Rehabilitation Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou, 350122, China.|Fujian Key Laboratory of Exercise Rehabilitation, Fuzhou, 350003, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Tao
authors.affiliation: The Second People's Hospital Affiliated to Fujian University of Traditional Chinese Medicine, Fuzhou, 350122, China.
authors.forename: Zhezhou
authors.initials: Z
authors.lastname: Zheng
authors.affiliation: Fujian University of Traditional Chinese Medicine, Fuzhou, 350122, China. cld@fjtcm.edu.cn.
authors.forename: Lidian
authors.initials: L
authors.lastname: Chen
mesh_terms: D000017:ABO Blood-Group System / Q000235:genetics*; D000368:Aged; D044466:Asian People / Q000235:genetics*; D002545:Brain Ischemia / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D011446:Prospective Studies; D020521:Stroke / Q000235:genetics*
chemical_list: D000017:ABO Blood-Group System
keywords: ABO; Association study; Ischemic stroke; Single nucleotide polymorphism