title: Evaluation and characterization of thyroid-disrupting activities in soil samples along the Second Songhua River, China.
abstract: In this study, a recombinant thyroid receptor (TR) gene yeast assay combined with Monte Carlo simulation were used to evaluate and characterize soil samples collected from Jilin (China) along the Second Songhua River, for their ant/agonist effect on TR. No TR agonistic activity was found in soils, but many soil samples exhibited TR antagonistic activities, and the bioassay-derived amiodarone hydrochloride equivalents, which was calculated based on Monte Carlo simulation, ranged from not detected (N.D.) to 35.5μg/g. Hydrophilic substance fractions were determined to be the contributors to TR antagonistic activity in these soil samples. Our results indicate that the novel calculation method is effective for the quantification and characterization of TR antagonists in soil samples, and these data could provide useful information for future management and remediation efforts for contaminated soils.
authors.affiliation: Engineering Research Center of Groundwater Pollution Control and Remediation, Ministry of Education, College of Water Sciences, Beijing Normal University, Beijing 100875, China.
authors.forename: Dongdong
authors.initials: D
authors.lastname: Kong
authors.affiliation: Engineering Research Center of Groundwater Pollution Control and Remediation, Ministry of Education, College of Water Sciences, Beijing Normal University, Beijing 100875, China.
authors.forename: Yafei
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Engineering Research Center of Groundwater Pollution Control and Remediation, Ministry of Education, College of Water Sciences, Beijing Normal University, Beijing 100875, China.
authors.forename: Jinsheng
authors.initials: J
authors.lastname: Wang
authors.affiliation: Engineering Research Center of Groundwater Pollution Control and Remediation, Ministry of Education, College of Water Sciences, Beijing Normal University, Beijing 100875, China.
authors.forename: Yanguo
authors.initials: Y
authors.lastname: Teng
authors.affiliation: State Key Laboratory of Environmental Aquatic Chemistry, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, P.O. Box 2871, Beijing 100085, China.
authors.forename: Na
authors.initials: N
authors.lastname: Li
authors.affiliation: Engineering Research Center of Groundwater Pollution Control and Remediation, Ministry of Education, College of Water Sciences, Beijing Normal University, Beijing 100875, China. Electronic address: lijian@bnu.edu.cn.
authors.forename: Jian
authors.initials: J
authors.lastname: Li
mesh_terms: D013956:Antithyroid Agents / Q000032:analysis*; D001681:Biological Assay / Q000379:methods; D002681:China; D052244:Endocrine Disruptors / Q000032:analysis / Q000494:pharmacology*; D004784:Environmental Monitoring / Q000379:methods; D009010:Monte Carlo Method; D011988:Receptors, Thyroid Hormone / Q000235:genetics / Q000378:metabolism*; D045483:Rivers; D012987:Soil / Q000737:chemistry*; D012989:Soil Pollutants / Q000032:analysis / Q000494:pharmacology*; D013961:Thyroid Gland; D014874:Water Pollutants, Chemical / Q000032:analysis; D015003:Yeasts
chemical_list: D013956:Antithyroid Agents; D052244:Endocrine Disruptors; D011988:Receptors, Thyroid Hormone; D012987:Soil; D012989:Soil Pollutants; D014874:Water Pollutants, Chemical
keywords: In vitro bioassay; Soil sample; Thyroid receptor; Thyroid-disrupting chemicals