title: Cardiovascular Alterations and Multiorgan Dysfunction After Birth Asphyxia.
abstract: The cardiovascular response to asphyxia involves redistribution of cardiac output to maintain oxygen delivery to critical organs such as the adrenal gland, heart, and brain, at the expense of other organs such as the gut, kidneys and skin. This redistribution results in reduced perfusion and localized hypoxia/ischemia in these organs, which, if severe, can result in multiorgan failure. Liver injury, coagulopathy, bleeding, thrombocytopenia, renal dysfunction, and pulmonary and gastrointestinal injury all result from hypoxia, underperfusion, or both. Current clinical therapies need to be considered together with therapeutic hypothermia and cardiovascular recovery.
authors.affiliation: The Ritchie Centre, Hudson Institute of Medical Research, 27-31 Wright Street, Clayton, Victoria 3168, Australia. Electronic address: graeme.polglase@monash.edu.
authors.forename: Graeme R
authors.initials: GR
authors.lastname: Polglase
authors.affiliation: The Ritchie Centre, Hudson Institute of Medical Research, 27-31 Wright Street, Clayton, Victoria 3168, Australia.
authors.forename: Tracey
authors.initials: T
authors.lastname: Ong
authors.affiliation: Department of Pediatrics, Saint Louis University, 1100 South Grand Boulevard, St Louis, MO 63124, USA.
authors.forename: Noah H
authors.initials: NH
authors.lastname: Hillman
mesh_terms: D058186:Acute Kidney Injury / Q000209:etiology / Q000503:physiopathology*; D001238:Asphyxia Neonatorum / Q000150:complications / Q000503:physiopathology*; D001778:Blood Coagulation Disorders / Q000209:etiology / Q000503:physiopathology; D002319:Cardiovascular System / Q000503:physiopathology*; D005260:Female; D005767:Gastrointestinal Diseases / Q000209:etiology / Q000503:physiopathology; D006470:Hemorrhage / Q000209:etiology / Q000503:physiopathology; D006801:Humans; D007036:Hypothermia, Induced; D020925:Hypoxia-Ischemia, Brain / Q000209:etiology / Q000503:physiopathology / Q000517:prevention & control; D007231:Infant, Newborn; D008107:Liver Diseases / Q000209:etiology / Q000503:physiopathology*; D008171:Lung Diseases / Q000209:etiology / Q000503:physiopathology; D009102:Multiple Organ Failure / Q000209:etiology / Q000503:physiopathology* / Q000517:prevention & control; D011247:Pregnancy; D013921:Thrombocytopenia / Q000209:etiology / Q000503:physiopathology
keywords: Asphyxia; Cardiovascular; Kidneys; Liver; Multiorgan failure