title: Nucleophosmin: from structure and function to disease development.
abstract: Nucleophosmin (NPM1) is a critical cellular protein that has been implicated in a number of pathways including mRNA transport, chromatin remodeling, apoptosis and genome stability. NPM1 function is a critical requirement for normal cellular biology as is underlined in cancer where NPM1 is commonly overexpressed, mutated, rearranged and sporadically deleted. Consistent with a multifunctional role within the cell, NPM1 can function not only as a proto-oncogene but also as a tumor suppressor. The aim of this review is to look at the less well-described role of NPM1 in the DNA repair pathways as well as the role of NPM1 in the regulation of apoptosis and its mutation in cancers.
authors.affiliation: School of Biomedical Research, Institute of Health and Biomedical Innovation at the Translational Research Institute, Queensland University of Technology, Brisbane, QLD, Australia.
authors.forename: Joseph K
authors.initials: JK
authors.lastname: Box
authors.affiliation: School of Biomedical Research, Institute of Health and Biomedical Innovation at the Translational Research Institute, Queensland University of Technology, Brisbane, QLD, Australia. nicolas.paquet@qut.edu.au.
authors.forename: Nicolas
authors.initials: N
authors.lastname: Paquet
authors.affiliation: School of Biomedical Research, Institute of Health and Biomedical Innovation at the Translational Research Institute, Queensland University of Technology, Brisbane, QLD, Australia.
authors.forename: Mark N
authors.initials: MN
authors.lastname: Adams
authors.affiliation: School of Biomedical Research, Institute of Health and Biomedical Innovation at the Translational Research Institute, Queensland University of Technology, Brisbane, QLD, Australia.
authors.forename: Didier
authors.initials: D
authors.lastname: Boucher
authors.affiliation: School of Biomedical Research, Institute of Health and Biomedical Innovation at the Translational Research Institute, Queensland University of Technology, Brisbane, QLD, Australia.
authors.forename: Emma
authors.initials: E
authors.lastname: Bolderson
authors.affiliation: School of Biomedical Research, Institute of Health and Biomedical Innovation at the Translational Research Institute, Queensland University of Technology, Brisbane, QLD, Australia.
authors.forename: Kenneth J
authors.initials: KJ
authors.lastname: O'Byrne
authors.affiliation: School of Biomedical Research, Institute of Health and Biomedical Innovation at the Translational Research Institute, Queensland University of Technology, Brisbane, QLD, Australia. derek.richard@qut.edu.au.
authors.forename: Derek J
authors.identifier: 0000-0002-4839-8471
authors.initials: DJ
authors.lastname: Richard
mesh_terms: D000818:Animals; D017209:Apoptosis; D004260:DNA Repair; D019143:Evolution, Molecular; D042822:Genomic Instability; D006801:Humans; D008958:Models, Molecular; D009154:Mutation; D009369:Neoplasms / Q000235:genetics* / Q000378:metabolism; D009687:Nuclear Proteins / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism*; D000090243:Nucleophosmin; D011487:Protein Conformation; D000090063:Proto-Oncogene Mas
chemical_list: C000715470:MAS1 protein, human; C000716967:NPM1 protein, human; D009687:Nuclear Proteins; D000090063:Proto-Oncogene Mas; D000090243:Nucleophosmin
keywords: Apoptosis; Cancer; DNA repair; Nucleophosmin 1