title: More hostile dyslipidaemia in chronic kidney disease patients on maintenance haemodialysis than on conservative management.
abstract: OBJECTIVE
  To study the pattern of dyslipidaemia in patients with stage-V chronic kidney disease on conservative management and those on maintenance haemodialysis.
  
  
  METHODS
  This comparative observational study was conducted at the Jinnah Postgraduate Medical Centre, Karachi, from February to July, 2008, and comprised stage-V chronic kidney disease patients. The patients were divided in two groups. Those who were on conservative management were placed in Group A, and those who were on maintenance haemodialysis were in Group B. Serum total lipid, cholesterol, triglycerides and high-density lipoprotein for both groups were assayed on chemical analyser and low-density lipoprotein was calculated by Friedwald equation. SPSS 17 was used for data analysis.
  
  
  RESULTS
  Of the 120 patients, there were 60(50%) in each group. The mean age of patients in Group A was 46.33±14.56 years and in Group B was 43.4±14.1years. Of all, 64(53.3%) were men and 56(46.7%) were women. Mean systolic and diastolic blood pressure was 134±19.58mmHg and 83.6±14.14mmHg in Group A and 129±19.7mmHg and 79.7±12.1mmHg in Group B. Mean serum total lipid was significantly higher (p<0.01) whereas mean serum cholesterol was significantly lower (p<0.01) in Group B. Comparison of mean serum triglycerides between the groups was also statistically significant (p<0.01) and was high in Group B. Mean serum high-density lipoprotein was lower in Group B (p<0.01). The difference between serum low-density lipoprotein levels was statistically insignificant between the groups (p=0.11).
  
  
  CONCLUSIONS
  Pattern of dyslipidaemia in patients on maintenance haemodialysis was more hostile than those on conservative management, and posed increased risk of coronary heart disease.
authors.affiliation: Department of Nephrology, Jinnah Postgraduate Medical Center, Karachi, Pakistan.
authors.forename: Teerath Kumar
authors.initials: TK
authors.lastname: Rathi
authors.affiliation: Department of Nephrology, The Kidney Centre Postgraduate Training Institute, Karachi, Pakistan.
authors.forename: Murtaza Fakhruddin
authors.initials: MF
authors.lastname: Dhrolia
authors.affiliation: Department of Nephrology, The Kidney Centre Postgraduate Training Institute, Karachi, Pakistan.
authors.forename: Salman
authors.initials: S
authors.lastname: Imtiaz
mesh_terms: D000328:Adult; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D000072700:Conservative Treatment; D050171:Dyslipidemias / Q000097:blood / Q000453:epidemiology*; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood / Q000453:epidemiology* / Q000628:therapy; D008075:Lipoproteins, HDL / Q000097:blood; D008297:Male; D008875:Middle Aged; D010154:Pakistan / Q000453:epidemiology; D006435:Renal Dialysis; D012720:Severity of Illness Index; D014280:Triglycerides / Q000097:blood
chemical_list: D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D008075:Lipoproteins, HDL; D014280:Triglycerides
keywords: Dyslipidaemia, Chronic kidney disease, Haemodialysis, Conservative management.