title: Predicting the optimal geometry of microneedles and their array for dermal vaccination using a computational model.
abstract: Microneedle arrays have been developed to deliver a range of biomolecules including vaccines into the skin. These microneedles have been designed with a wide range of geometries and arrangements within an array. However, little is known about the effect of the geometry on the potency of the induced immune response. The aim of this study was to develop a computational model to predict the optimal design of the microneedles and their arrangement within an array. The three-dimensional finite element model described the diffusion and kinetics in the skin following antigen delivery with a microneedle array. The results revealed an optimum distance between microneedles based on the number of activated antigen presenting cells, which was assumed to be related to the induced immune response. This optimum depends on the delivered dose. In addition, the microneedle length affects the number of cells that will be involved in either the epidermis or dermis. By contrast, the radius at the base of the microneedle and release rate only minimally influenced the number of cells that were activated. The model revealed the importance of various geometric parameters to enhance the induced immune response. The model can be developed further to determine the optimal design of an array by adjusting its various parameters to a specific situation.
authors.affiliation: a Soft Tissue Biomechanics and Engineering, Department of Biomedical Engineering , Eindhoven University of Technology , Eindhoven , The Netherlands.
authors.forename: Anne M
authors.initials: AM
authors.lastname: Römgens
authors.affiliation: a Soft Tissue Biomechanics and Engineering, Department of Biomedical Engineering , Eindhoven University of Technology , Eindhoven , The Netherlands.|b Faculty of Health Sciences , University of Southampton , Southampton , UK.
authors.forename: Dan L
authors.initials: DL
authors.lastname: Bader
authors.affiliation: c Division of Drug Delivery Technology, Leiden Academic Centre for Drug Research , Leiden University , Leiden , The Netherlands.
authors.forename: Joke A
authors.initials: JA
authors.lastname: Bouwstra
authors.affiliation: a Soft Tissue Biomechanics and Engineering, Department of Biomedical Engineering , Eindhoven University of Technology , Eindhoven , The Netherlands.
authors.forename: Cees W J
authors.initials: CW
authors.lastname: Oomens
mesh_terms: D000279:Administration, Cutaneous; D003198:Computer Simulation; D006801:Humans; D008962:Models, Theoretical; D009339:Needles; D012867:Skin; D014611:Vaccination / Q000379:methods*
keywords: Finite element model; antigen kinetics; microneedles; pharmacokinetic model; vaccine delivery