title: The Combined Usefulness of the Neutrophil-to-Lymphocyte and Platelet-to-Lymphocyte Ratios in Predicting Intravenous Immunoglobulin Resistance with Kawasaki Disease.
abstract: The laboratory records of 405 patients with Kawasaki disease before and after intravenous immunoglobulin (IVIG) therapy were compared between the IVIG-responsive (n = 320) and IVIG-resistant (n = 85) groups. A high neutrophil-to-lymphocyte ratio and a high platelet-to-lymphocyte ratio before IVIG, especially when combined, were useful predictors for IVIG resistance in Kawasaki disease.
authors.affiliation: Department of Pediatrics, National Defense Medical College, Tokorozawa, Saitama, Japan.
authors.forename: Yoichi
authors.initials: Y
authors.lastname: Kawamura
authors.affiliation: Division of Nursing, National Defense Medical College, Tokorozawa, Saitama, Japan. Electronic address: takeshit@ndmc.ac.jp.
authors.forename: Seiichiro
authors.initials: S
authors.lastname: Takeshita
authors.affiliation: Department of Pediatrics, National Defense Medical College, Tokorozawa, Saitama, Japan; Department of Pediatrics, Japan Self-Defense Forces Central Hospital, Setagaya, Tokyo, Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Kanai
authors.affiliation: Department of Pediatrics, National Defense Medical College, Tokorozawa, Saitama, Japan.
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Yoshida
authors.affiliation: Department of Pediatrics, National Defense Medical College, Tokorozawa, Saitama, Japan.
authors.forename: Shigeaki
authors.initials: S
authors.lastname: Nonoyama
mesh_terms: D001772:Blood Cell Count / Q000379:methods*; D001792:Blood Platelets / Q000166:cytology*; D002675:Child, Preschool; D004351:Drug Resistance; D005260:Female; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use; D007223:Infant; D008214:Lymphocytes / Q000166:cytology*; D008297:Male; D009080:Mucocutaneous Lymph Node Syndrome / Q000097:blood* / Q000188:drug therapy; D009504:Neutrophils / Q000166:cytology*; D011237:Predictive Value of Tests; D012189:Retrospective Studies; D012680:Sensitivity and Specificity
chemical_list: D016756:Immunoglobulins, Intravenous
keywords: coronary artery abnormality; white blood cell