title: Therapies for Prevention and Treatment of Alzheimer's Disease.
abstract: Alzheimer's disease (AD) is the most common cause of dementia associated with a progressive neurodegenerative disorder, with a prevalence of 44 million people throughout the world in 2015, and this figure is estimated to double by 2050. This disease is characterized by blood-brain barrier disruption, oxidative stress, mitochondrial impairment, neuroinflammation, and hypometabolism; it is related to amyloid-β peptide accumulation and tau hyperphosphorylation as well as a decrease in acetylcholine levels and a reduction of cerebral blood flow. Obesity is a major risk factor for AD, because it induces adipokine dysregulation, which consists of the release of the proinflammatory adipokines and decreased anti-inflammatory adipokines, among other processes. The pharmacological treatments for AD can be divided into two categories: symptomatic treatments such as acetylcholinesterase inhibitors and N-methyl-D-aspartate (NMDA) receptor antagonists and etiology-based treatments such as secretase inhibitors, amyloid binders, and tau therapies. Strategies for prevention of AD through nonpharmacological treatments are associated with lifestyle interventions such as exercise, mental challenges, and socialization as well as caloric restriction and a healthy diet. AD is an important health issue on which all people should be informed so that prevention strategies that minimize the risk of its development may be implemented.
authors.affiliation: Laboratorio de Investigación Genética, Facultad de Química, Universidad Autónoma de Querétaro, Cerro de las Campanas S/N, Centro Universitario, 76010 Santiago de Querétaro, QRO, Mexico.
authors.forename: J
authors.identifier: 0000-0002-7420-0211
authors.initials: J
authors.lastname: Mendiola-Precoma
authors.affiliation: Laboratorio de Investigación Genética, Facultad de Química, Universidad Autónoma de Querétaro, Cerro de las Campanas S/N, Centro Universitario, 76010 Santiago de Querétaro, QRO, Mexico.
authors.forename: L C
authors.identifier: 0000-0001-6266-3457
authors.initials: LC
authors.lastname: Berumen
authors.affiliation: Laboratorio de Investigación Genética, Facultad de Química, Universidad Autónoma de Querétaro, Cerro de las Campanas S/N, Centro Universitario, 76010 Santiago de Querétaro, QRO, Mexico.
authors.forename: K
authors.identifier: 0000-0002-4777-6135
authors.initials: K
authors.lastname: Padilla
authors.affiliation: Laboratorio de Investigación Genética, Facultad de Química, Universidad Autónoma de Querétaro, Cerro de las Campanas S/N, Centro Universitario, 76010 Santiago de Querétaro, QRO, Mexico.
authors.forename: G
authors.identifier: 0000-0002-7768-344X
authors.initials: G
authors.lastname: Garcia-Alcocer
mesh_terms: D000544:Alzheimer Disease / Q000453:epidemiology / Q000503:physiopathology / Q000517:prevention & control* / Q000628:therapy*; D006801:Humans; D009765:Obesity; D012307:Risk Factors