title: The pathogenicity of novel duck reovirus in Cherry Valley ducks.
abstract: The novel duck reovirus (NDRV) is an emerging, contagious infection. To better realize the pathogenic mechanism of NDRV in ducks, an infection experiment was conducted. The resulting data demonstrated that typical gross lesions were observed in the infected ducks. NDRV was able to replicate in various tissues, leading to these pathological lesions, especially on the liver and spleen. Real-time quantitative PCR showed that the expression of most innate immune-related genes was up-regulated and the antiviral innate immune response could be established in both the liver and spleen. This study indicates that NDRV is a pantropic virus. To resist viral infection, several pathogen recognition receptors can cooperatively recognize NDRV and initiate innate immunity, but the responses are different between different tissues. As far as we know, this is the first systematic investigation of the pathogenicity of NDRV in Cherry Valley ducks based on the host's innate immunity, and these data will provide new insights into the further study of the disease.
authors.affiliation: College of Veterinary Medicine, Shandong Agricultural University, Sino-German Cooperative Research Centre for Zoonosis of Animal Origin Shandong Province, 61 Daizong Road, Tai'an 271000, Shandong Province, China; Collaborative Innovation Centre for the Origin and Control of Emerging Infectious Diseases of Taishan Medical College, Tai'an 271000, Shandong Province, China.
authors.forename: Ning
authors.initials: N
authors.lastname: Li
authors.affiliation: College of Veterinary Medicine, Shandong Agricultural University, Sino-German Cooperative Research Centre for Zoonosis of Animal Origin Shandong Province, 61 Daizong Road, Tai'an 271000, Shandong Province, China.
authors.forename: Tianqi
authors.initials: T
authors.lastname: Hong
authors.affiliation: College of Veterinary Medicine, Shandong Agricultural University, Sino-German Cooperative Research Centre for Zoonosis of Animal Origin Shandong Province, 61 Daizong Road, Tai'an 271000, Shandong Province, China.
authors.forename: Yao
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Institute of Poultry Science, Shandong Academy of Agricultural Sciences, Jinan 250000, Shandong Province, China.
authors.forename: Youling
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Institute of Poultry Science, Shandong Academy of Agricultural Sciences, Jinan 250000, Shandong Province, China.
authors.forename: Kexiang
authors.initials: K
authors.lastname: Yu
authors.affiliation: College of Veterinary Medicine, Shandong Agricultural University, Sino-German Cooperative Research Centre for Zoonosis of Animal Origin Shandong Province, 61 Daizong Road, Tai'an 271000, Shandong Province, China.
authors.forename: Yumei
authors.initials: Y
authors.lastname: Cai
authors.affiliation: College of Veterinary Medicine, Shandong Agricultural University, Sino-German Cooperative Research Centre for Zoonosis of Animal Origin Shandong Province, 61 Daizong Road, Tai'an 271000, Shandong Province, China.
authors.forename: Sidang
authors.initials: S
authors.lastname: Liu
authors.affiliation: College of Veterinary Medicine, Shandong Agricultural University, Sino-German Cooperative Research Centre for Zoonosis of Animal Origin Shandong Province, 61 Daizong Road, Tai'an 271000, Shandong Province, China; Collaborative Innovation Centre for the Origin and Control of Emerging Infectious Diseases of Taishan Medical College, Tai'an 271000, Shandong Province, China. Electronic address: lmwei@sdau.edu.cn.
authors.forename: Liangmeng
authors.initials: L
authors.lastname: Wei
authors.affiliation: College of Veterinary Medicine, Shandong Agricultural University, Sino-German Cooperative Research Centre for Zoonosis of Animal Origin Shandong Province, 61 Daizong Road, Tai'an 271000, Shandong Province, China; Collaborative Innovation Centre for the Origin and Control of Emerging Infectious Diseases of Taishan Medical College, Tai'an 271000, Shandong Province, China. Electronic address: chaitj117@163.com.
authors.forename: Tongjie
authors.initials: T
authors.lastname: Chai
mesh_terms: D000818:Animals; D004372:Ducks; D005786:Gene Expression Regulation / Q000276:immunology; D007113:Immunity, Innate; D008099:Liver / Q000276:immunology / Q000473:pathology; D030101:Orthoreovirus, Avian / Q000472:pathogenicity*; D011201:Poultry Diseases / Q000473:pathology / Q000821:virology*; D012367:RNA, Viral / Q000302:isolation & purification; D013154:Spleen / Q000276:immunology / Q000473:pathology; D019562:Viral Load
chemical_list: D012367:RNA, Viral
keywords: Cherry Valley duck; Innate immunity; Novel duck reovirus; Pathogenicity