title: ADAM 10 expression in primary uveal melanoma as prognostic factor for risk of metastasis.
abstract: Uveal melanoma is the most frequent primary intraocular neoplasm in adults. Although malignant melanoma may be located at any point in the uveal tract, the choroid and ciliary body are more frequent locations than the iris. In the present study, we examined ADAM10 expression levels in primary uveal melanoma both with and without metastasis, and we evaluated their association with other high risk characteristics for metastasis in order to assess if ADAM10 can be used to predict metastasis. This study included a total of 52 patients, 23 men and 29 women, with uveal melanoma. A significantly high expression of ADAM-10 was seen in patients with metastasis (11/13, 84.6%), but not in patients without metastasis (15/39, 38.5%). In conclusion we found that ADAM10 expression was associated with a more rapid metastatic progression confirming its role in uveal melanoma metastasis.
authors.affiliation: Department G.F. Ingrassia, Section of Anatomic Pathology, University of Catania, Italy. Electronic address: rosario.caltabiano@unict.it.
authors.forename: Rosario
authors.initials: R
authors.lastname: Caltabiano
authors.affiliation: Department G.F. Ingrassia, Section of Anatomic Pathology, University of Catania, Italy.
authors.forename: Lidia
authors.initials: L
authors.lastname: Puzzo
authors.affiliation: Department of Human Pathology, Section of Pathological Anatomy, University of Messina, Italy.
authors.forename: Valeria
authors.initials: V
authors.lastname: Barresi
authors.affiliation: Department of Human Pathology, Section of Pathological Anatomy, University of Messina, Italy.
authors.forename: Antonio
authors.initials: A
authors.lastname: Ieni
authors.affiliation: Department of Bio-medical Sciences, Division of Anatomy and Histology, University of Catania, Italy.
authors.forename: Carla
authors.initials: C
authors.lastname: Loreto
authors.affiliation: Department of Bio-medical Sciences, Division of Anatomy and Histology, University of Catania, Italy.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Musumeci
authors.affiliation: Department of Bio-medical Sciences, Division of Anatomy and Histology, University of Catania, Italy.
authors.forename: Paola
authors.initials: P
authors.lastname: Castrogiovanni
authors.affiliation: Department of Bio-medical Sciences, Section of Molecular Biomedicine, University of Catania, Italy.
authors.forename: Marco
authors.initials: M
authors.lastname: Ragusa
authors.affiliation: Radiodiagnostic and Radiotherapy Unit, University Hospital "Policlinico-Vittorio Emanuele", Italy.
authors.forename: Pietro
authors.initials: P
authors.lastname: Foti
authors.affiliation: Department of Ophthalmology, University of Catania, Catania, Italy.
authors.forename: Andrea
authors.initials: A
authors.lastname: Russo
authors.affiliation: Department of Ophthalmology, University of Catania, Catania, Italy.
authors.forename: Antonio
authors.initials: A
authors.lastname: Longo
authors.affiliation: Department of Ophthalmology, University of Catania, Catania, Italy.
authors.forename: Michele
authors.initials: M
authors.lastname: Reibaldi
mesh_terms: D000072197:ADAM10 Protein / Q000096:biosynthesis*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D053829:Amyloid Precursor Protein Secretases / Q000096:biosynthesis*; D014408:Biomarkers, Tumor / Q000032:analysis*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D017404:In Situ Hybridization, Fluorescence; D053208:Kaplan-Meier Estimate; D008297:Male; D008545:Melanoma / Q000378:metabolism / Q000401:mortality / Q000473:pathology*; D008565:Membrane Proteins / Q000096:biosynthesis*; D008875:Middle Aged; D009361:Neoplasm Invasiveness / Q000473:pathology; D009362:Neoplasm Metastasis; D011379:Prognosis; D016016:Proportional Hazards Models; D012189:Retrospective Studies; D012307:Risk Factors; D014604:Uveal Neoplasms / Q000378:metabolism / Q000401:mortality / Q000473:pathology*; D000098943:Uveal Melanoma
chemical_list: D014408:Biomarkers, Tumor; D008565:Membrane Proteins; D053829:Amyloid Precursor Protein Secretases; D000072197:ADAM10 Protein; C491236:ADAM10 protein, human
keywords: ADAM 10; Immunohistochemistry; Metastasis; Prognosis; Uveal melanoma