title: Metabolic and immunologic aspects of fetoplacental insufficiency.
abstract: The chronic placental insufficiency is the most common cause of intrauterine hypoxia, retardation of fetal growth, and other threatening conditions. Immune disturbances may occur in the system "mother-placenta-fetus."
  
  
  
  Biochemical blood indicators were studied on an automated biochemical analyzer. Pattern of lymphocyte subpopulations was detected by direct membrane immunofluorescence.
  
  
  
  Study revealed imbalance of immune parameters, caused by placental insufficiency (increase natural killers (CD16(+) , CD56(+) ), B lymphocytes (CD19(+) CD3(-) ), T and B lymphocytes with HLA-DR(+) antigen, and early activation of immune cells (by CD25(+) ), as well as disorders in apoptotic mechanisms (by CD95(+) )).
  
  
  
  Placental insufficiency leads to abnormalities of the immune system in pregnant, parturient women and maternity patients which were evaluated by localization of activation markers CD25(+) CD95(+) on the CD3(+) , CD4(+) , CD8(+) , CD16(+) , CD56(+) lymphocytes. This is reflected in the change of lymphocyte functions in newborns.
authors.affiliation: Marat Ospanov West-Kazakhstan State Medical University, Aktobe, Kazakhstan.
authors.forename: Yerbol
authors.initials: Y
authors.lastname: Bekmukhambetov
authors.affiliation: Marat Ospanov West-Kazakhstan State Medical University, Aktobe, Kazakhstan. mamyrbayev.arstan@gmail.com.
authors.forename: Arstan
authors.initials: A
authors.lastname: Mamyrbayev
authors.affiliation: Marat Ospanov West-Kazakhstan State Medical University, Aktobe, Kazakhstan.
authors.forename: Timur
authors.initials: T
authors.lastname: Dzharkenov
authors.affiliation: Scientific Center of Obstetrics, Gynecology and Perinatology, Ministry of Health of the Republic of Kazakhstan, Almaty, Kazakhstan.
authors.forename: Natalia
authors.initials: N
authors.lastname: Kravtsova
authors.affiliation: Scientific Center of Obstetrics, Gynecology and Perinatology, Ministry of Health of the Republic of Kazakhstan, Almaty, Kazakhstan.
authors.forename: Zhanar
authors.initials: Z
authors.lastname: Utesheva
authors.affiliation: Marat Ospanov West-Kazakhstan State Medical University, Aktobe, Kazakhstan.
authors.forename: Akylbek
authors.initials: A
authors.lastname: Tusupkaliev
authors.affiliation: Marat Ospanov West-Kazakhstan State Medical University, Aktobe, Kazakhstan.
authors.forename: Svetlana
authors.initials: S
authors.lastname: Ryzhkova
authors.affiliation: Marat Ospanov West-Kazakhstan State Medical University, Aktobe, Kazakhstan.
authors.forename: Klara
authors.initials: K
authors.lastname: Darzhanova
authors.affiliation: Marat Ospanov West-Kazakhstan State Medical University, Aktobe, Kazakhstan.
authors.forename: Maral
authors.initials: M
authors.lastname: Bekzhanova
mesh_terms: D000328:Adult; D015703:Antigens, CD; D017209:Apoptosis; D001402:B-Lymphocytes / Q000276:immunology*; D005260:Female; D005317:Fetal Growth Retardation / Q000276:immunology / Q000378:metabolism*; D006684:HLA-DR Antigens / Q000378:metabolism; D006801:Humans; D016130:Immunophenotyping; D007694:Killer Cells, Natural / Q000276:immunology*; D008213:Lymphocyte Activation; D010920:Placenta / Q000276:immunology*; D021041:Placental Circulation; D010927:Placental Insufficiency / Q000276:immunology / Q000378:metabolism*; D011247:Pregnancy; D013601:T-Lymphocytes / Q000276:immunology*
chemical_list: D015703:Antigens, CD; D006684:HLA-DR Antigens
keywords: fetoplacental insufficiency; immune system imbalance; metabolism; pattern of lymphocyte subpopulations