title: Protective Effects of Dracocephalum heterophyllum in ConA-Induced Acute Hepatitis.
abstract: Dracocephalum heterophyllum (DH) is a Chinese herbal medicine used in treating hepatitis. However, the protective effects and pharmacological mechanisms of DH in hepatitis are unknown. In this study, we found that pretreatment with DH extract significantly ameliorated liver injury and suppressed the production of inflammatory cytokines, including tumor necrosis factor (TNF-α) and interferon-γ (IFN-γ) in Concanavalin A- (ConA-) induced hepatitis (CIH). DH recruited more CD11b(+) Gr1(+) myeloid-derived suppressor cells (MDSCs) to the liver and suppressed infiltration of macrophages (Kupffer cells) in the liver. The present work explores DH as an effective hepatoprotective medicine to inhibit inflammation and liver injury caused by hepatitis.
authors.affiliation: Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China; Institute of Military Veterinary Medicine, Academy of Military Medical Science, Changchun 130122, China.
authors.forename: Wei
authors.identifier: 0000-0002-8942-1543
authors.initials: W
authors.lastname: Zheng
authors.affiliation: Northwest Plateau Institute of Biology, Chinese Academy of Sciences, Xining 810001, China.
authors.forename: Qilan
authors.initials: Q
authors.lastname: Wang
authors.affiliation: Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China.
authors.forename: Xiaohua
authors.initials: X
authors.lastname: Lu
authors.affiliation: Northwest Plateau Institute of Biology, Chinese Academy of Sciences, Xining 810001, China.
authors.forename: Qiangqiang
authors.initials: Q
authors.lastname: Shi
authors.affiliation: Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China.
authors.forename: Junhui
authors.initials: J
authors.lastname: Zou
authors.affiliation: Northwest Plateau Institute of Biology, Chinese Academy of Sciences, Xining 810001, China.
authors.forename: Yanduo
authors.identifier: 0000-0003-3970-9837
authors.initials: Y
authors.lastname: Tao
authors.affiliation: Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China.
authors.forename: Pu
authors.identifier: 0000-0001-6555-0845
authors.initials: P
authors.lastname: Wang
mesh_terms: D000208:Acute Disease; D000818:Animals; D003208:Concanavalin A / Q000633:toxicity*; D005260:Female; D005434:Flow Cytometry; D006505:Hepatitis / Q000188:drug therapy* / Q000209:etiology; D020287:In Situ Nick-End Labeling; D007371:Interferon-gamma / Q000378:metabolism; D019686:Lamiaceae / Q000737:chemistry*; D008099:Liver / Q000166:cytology / Q000378:metabolism; D051379:Mice; D008807:Mice, Inbred BALB C; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
chemical_list: D010936:Plant Extracts; D014409:Tumor Necrosis Factor-alpha; D003208:Concanavalin A; D007371:Interferon-gamma