title: Type 2 diabetes is associated with decreased PGC1α expression in epicardial adipose tissue of patients with coronary artery disease.
abstract: Although recent studies indicate that epicardial adipose tissue expresses brown fat-like genes, such as PGC1α, UCP1 and PRDM16, the association of these genes with type 2 diabetes mellitus (DM2) in coronary artery disease (CAD) remains unknown.
  
  
  
  PGC1α, UCP1, and PRDM16 mRNAs expression levels were measured by real-time PCR in epicardial and thoracic subcutaneous adipose tissue from 44 CAD patients (22 with DM2 [CAD-DM2] and 22 without DM2 [CAD-NDM2]) and 23 non-CAD patients (NCAD).
  
  
  
  The CAD-DM2 patients had significantly lower PGC1α and UCP1 expression in epicardial adipose tissue than the CAD-NDM2 and NCAD patients. However, PGC1α and UCP1 mRNA trended upward in subcutaneous adipose tissue from CAD-DM2 patients. At multiple regression analysis, age, body mass index, left ventricular ejection fraction, UCP1 expression of epicardial adipose tissue and diabetes came out to be independent predictors of PGC1α levels. Epicardial adipose tissue PGC1α expression was dependent on the number of injured coronary arteries and logistic regression analysis showed that PGC1α expression in epicardial adipose tissue could exert a protective effect against coronary lesions.
  
  
  
  DM2 is associated with decreased expression of PGC1α and UCP1 mRNA in epicardial adipose tissue of patients with CAD, likely reflecting a loss of brown-like fat features. Decreased expression of PGC1α in human epicardial adipose tissue is associated with higher prevalence of coronary lesions.
authors.affiliation: Unidad de Gestión Clínica Área del Corazón, Instituto de Investigación Biomédica de Málaga (IBIMA), Hospital Universitario de Málaga (Virgen de la Victoria), Universidad de Málaga, Red de Investigación Cardiovascular (RIC), Málaga, Spain. morenosantos.inma@gmail.com.
authors.forename: Inmaculada
authors.initials: I
authors.lastname: Moreno-Santos
authors.affiliation: Unidad de Gestión Clínica Área del Corazón, Instituto de Investigación Biomédica de Málaga (IBIMA), Hospital Universitario de Málaga (Virgen de la Victoria), Universidad de Málaga, Red de Investigación Cardiovascular (RIC), Málaga, Spain.
authors.forename: Luis Miguel
authors.initials: LM
authors.lastname: Pérez-Belmonte
authors.affiliation: Unidad de Gestión Clínica de Endocrinología y Nutrición, Instituto de Investigación Biomédica de Málaga (IBIMA), Hospital Universitario de Málaga (Virgen de la Victoria), Universidad de Málaga, CIBER Pathophysiology of Obesity and Nutrition, Málaga, Spain.
authors.forename: Manuel
authors.initials: M
authors.lastname: Macías-González
authors.affiliation: Unidad de Gestión Clínica Área del Corazón, Instituto de Investigación Biomédica de Málaga (IBIMA), Hospital Universitario de Málaga (Virgen de la Victoria), Universidad de Málaga, Red de Investigación Cardiovascular (RIC), Málaga, Spain.
authors.forename: María José
authors.initials: MJ
authors.lastname: Mataró
authors.affiliation: Unidad de Gestión Clínica de Endocrinología y Nutrición, Instituto de Investigación Biomédica de Málaga (IBIMA), Hospital Universitario de Málaga (Virgen de la Victoria), Universidad de Málaga, CIBER Pathophysiology of Obesity and Nutrition, Málaga, Spain.
authors.forename: Daniel
authors.initials: D
authors.lastname: Castellano
authors.affiliation: Unidad de Gestión Clínica Área del Corazón, Instituto de Investigación Biomédica de Málaga (IBIMA), Hospital Universitario de Málaga (Virgen de la Victoria), Universidad de Málaga, Red de Investigación Cardiovascular (RIC), Málaga, Spain.
authors.forename: Miguel
authors.initials: M
authors.lastname: López-Garrido
authors.affiliation: Unidad de Gestión Clínica Área del Corazón, Instituto de Investigación Biomédica de Málaga (IBIMA), Hospital Universitario de Málaga (Virgen de la Victoria), Universidad de Málaga, Red de Investigación Cardiovascular (RIC), Málaga, Spain.
authors.forename: Carlos
authors.initials: C
authors.lastname: Porras-Martín
authors.affiliation: Servicio de Cardiología, Hospital Universitario de Salamanca, Instituto de Investigación Biomédica de Salamanca (IBISAL), Red de Investigación Cardiovascular (RIC), Universidad de Salamanca (USAL), Salamanca, Spain.
authors.forename: Pedro L
authors.initials: PL
authors.lastname: Sánchez-Fernández
authors.affiliation: Unidad de Gestión Clínica Área del Corazón, Instituto de Investigación Biomédica de Málaga (IBIMA), Hospital Universitario de Málaga (Virgen de la Victoria), Universidad de Málaga, Red de Investigación Cardiovascular (RIC), Málaga, Spain.
authors.forename: Juan José
authors.initials: JJ
authors.lastname: Gómez-Doblas
authors.affiliation: Unidad de Gestión Clínica de Endocrinología y Nutrición, Instituto de Investigación Biomédica de Málaga (IBIMA), Hospital Universitario de Málaga (Virgen de la Victoria), Universidad de Málaga, CIBER Pathophysiology of Obesity and Nutrition, Málaga, Spain. fernandocardonadiaz@gmail.com.
authors.forename: Fernando
authors.initials: F
authors.lastname: Cardona
authors.affiliation: Unidad de Gestión Clínica Área del Corazón, Instituto de Investigación Biomédica de Málaga (IBIMA), Hospital Universitario de Málaga (Virgen de la Victoria), Universidad de Málaga, Red de Investigación Cardiovascular (RIC), Málaga, Spain.
authors.forename: Eduardo
authors.initials: E
authors.lastname: de Teresa-Galván
authors.affiliation: Unidad de Gestión Clínica Área del Corazón, Instituto de Investigación Biomédica de Málaga (IBIMA), Hospital Universitario de Málaga (Virgen de la Victoria), Universidad de Málaga, Red de Investigación Cardiovascular (RIC), Málaga, Spain.
authors.forename: Manuel
authors.initials: M
authors.lastname: Jiménez-Navarro
mesh_terms: D000273:Adipose Tissue / Q000378:metabolism*; D003324:Coronary Artery Disease / Q000150:complications* / Q000235:genetics* / Q000473:pathology; D004268:DNA-Binding Proteins / Q000235:genetics / Q000378:metabolism; D003924:Diabetes Mellitus, Type 2 / Q000150:complications* / Q000235:genetics* / Q000473:pathology; D005260:Female; D005786:Gene Expression Regulation; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D010496:Pericardium / Q000378:metabolism* / Q000473:pathology; D000071248:Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha / Q000235:genetics* / Q000378:metabolism; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D050151:Subcutaneous Fat / Q000378:metabolism; D022722:Thermogenesis / Q000235:genetics; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism; D000071256:Uncoupling Protein 1 / Q000235:genetics / Q000378:metabolism
chemical_list: D004268:DNA-Binding Proteins; C486497:PPARGC1A protein, human; C416371:PRDM16 protein, human; D000071248:Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; D012333:RNA, Messenger; D014157:Transcription Factors; C000604371:UCP1 protein, human; D000071256:Uncoupling Protein 1
keywords: Coronary artery disease; Epicardial adipose tissue; Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC1α); Type 2 diabetes mellitus