title: "Smart" drug loaded nanoparticle delivery from a self-healing hydrogel enabled by dynamic magnesium-biopolymer chemistry.
abstract: We report a strategy to generate a self-healing and pH responsive hydrogel network between drug-loaded nanoparticles and natural polysaccharides via magnesium-bisphosphonate ligand interactions. The injectable drug depot disassembles in a tumor-specific environment, providing localized uptake of the nanoparticles, which is highly appreciated in drug delivery applications and manufacturing of drug-loaded biomaterials using a syringe-based deposition technique.
authors.affiliation: Science for Life Laboratory, Division of Polymer Chemistry, Department of Chemistry-Ångström, Uppsala University, Uppsala, SE 751 21, Sweden. dmitri.ossipov@kemi.uu.se.
authors.forename: Liyang
authors.initials: L
authors.lastname: Shi
authors.forename: Yuanyuan
authors.initials: Y
authors.lastname: Han
authors.forename: Jöns
authors.initials: J
authors.lastname: Hilborn
authors.forename: Dmitri
authors.initials: D
authors.lastname: Ossipov