title: Histoplasmosis mimicking non-Hodgkin lymphoma in a 40-year-old man with AIDS.
abstract: In patients with acquired immunodeficiency syndrome (AIDS), advanced immunosuppression is associated with atypical presentation of dermatological conditions. Our patient presented with a single crusted plaque over the lower lip and large tender cervical lymphadenopathy. The enzyme-linked immunosorbent assay for human immunodeficiency virus was found to be positive, and his CD4+ lymphocyte cell count was 4 cells/mm3. The presence of multiple histoplasma spores in the biopsies from the crusted plaque over lip and cervical lymph node helped in the confirmation of the diagnosis of histoplasmosis, and the patient showed significant improvement within two months of treatment with conventional injection amphotericin B initially followed by oral itraconazole.
authors.affiliation: 1 Department of Dermatology and Venereology, All India Institute of Medical Sciences, New Delhi, India.
authors.forename: Neetu
authors.initials: N
authors.lastname: Bhari
authors.affiliation: 1 Department of Dermatology and Venereology, All India Institute of Medical Sciences, New Delhi, India.
authors.forename: Piyush
authors.initials: P
authors.lastname: Pahadiya
authors.affiliation: 2 Department of Pathology, All India Institute of Medical Sciences, New Delhi, India.
authors.forename: Sudheer
authors.initials: S
authors.lastname: Arava
authors.affiliation: 1 Department of Dermatology and Venereology, All India Institute of Medical Sciences, New Delhi, India.
authors.forename: Somesh
authors.initials: S
authors.lastname: Gupta
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000150:complications*; D000328:Adult; D000666:Amphotericin B / Q000008:administration & dosage*; D000935:Antifungal Agents / Q000008:administration & dosage*; D001706:Biopsy; D018791:CD4 Lymphocyte Count; D003840:Deoxycholic Acid / Q000008:administration & dosage*; D004338:Drug Combinations; D004797:Enzyme-Linked Immunosorbent Assay; D006658:Histoplasma / Q000302:isolation & purification*; D006660:Histoplasmosis / Q000000981:diagnostic imaging* / Q000188:drug therapy / Q000382:microbiology / Q000473:pathology; D006801:Humans; D017964:Itraconazole / Q000008:administration & dosage*; D008198:Lymph Nodes / Q000473:pathology; D008228:Lymphoma, Non-Hodgkin / Q000473:pathology; D008297:Male; D016896:Treatment Outcome
chemical_list: D000935:Antifungal Agents; D004338:Drug Combinations; D003840:Deoxycholic Acid; D017964:Itraconazole; D000666:Amphotericin B; C059765:amphotericin B, deoxycholate drug combination
keywords: HIV; Histoplasmosis; non-Hodgkin lymphoma