title: Brain-kidney cross-talk: Definition and emerging evidence.
abstract: Cross-talk is broadly defined as endogenous homeostatic signaling between vital organs such as the heart, kidneys and brain. Kidney-brain cross-talk remains an area with excitingly few publications despite its purported clinical relevance in the management of currently undertreated conditions such as resistant hypertension. Therefore, this review aims to establish an organ-specific definition for kidney-brain cross-talk and review the available and forthcoming literature on this topic.
authors.affiliation: Department of Medicine, Division of Nephrology, Konya Numune State Hospital, Konya, Turkey.
authors.forename: Baris
authors.initials: B
authors.lastname: Afsar
authors.affiliation: Department of Radiology, Division of Interventional Radiology, Koc University School of Medicine, Istanbul, Turkey.
authors.forename: Alan A
authors.initials: AA
authors.lastname: Sag
authors.affiliation: Department of Medicine, Koc University School of Medicine, Istanbul, Turkey.
authors.forename: Can Ege
authors.initials: CE
authors.lastname: Yalcin
authors.affiliation: Department of Medicine, Koc University School of Medicine, Istanbul, Turkey.
authors.forename: Eren
authors.initials: E
authors.lastname: Kaya
authors.affiliation: Nephrology Clinic, Dialysis and Renal Transplant Center, 'C.I. PARHON' University Hospital, and 'Grigore T. Popa' University of Medicine, Iasi, Romania.
authors.forename: Dimitrie
authors.initials: D
authors.lastname: Siriopol
authors.affiliation: Renal and Transplantation Department, Guy's and St Thomas' Hospitals, London, UK.
authors.forename: David
authors.initials: D
authors.lastname: Goldsmith
authors.affiliation: Nephrology Clinic, Dialysis and Renal Transplant Center, 'C.I. PARHON' University Hospital, and 'Grigore T. Popa' University of Medicine, Iasi, Romania.
authors.forename: Adrian
authors.initials: A
authors.lastname: Covic
authors.affiliation: Department of Medicine, Division of Nephrology, Koc University School of Medicine, Istanbul, Turkey. Electronic address: mkanbay@ku.edu.tr.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Kanbay
mesh_terms: D001794:Blood Pressure / Q000502:physiology; D001812:Blood-Brain Barrier / Q000378:metabolism; D001921:Brain / Q000378:metabolism / Q000502:physiology* / Q000503:physiopathology; D001927:Brain Diseases / Q000150:complications / Q000378:metabolism / Q000503:physiopathology*; D006801:Humans; D007668:Kidney / Q000378:metabolism / Q000502:physiology* / Q000503:physiopathology; D049292:Leukoaraiosis / Q000150:complications / Q000503:physiopathology; D009994:Osmolar Concentration; D006435:Renal Dialysis; D051437:Renal Insufficiency / Q000150:complications / Q000378:metabolism / Q000503:physiopathology*; D051436:Renal Insufficiency, Chronic / Q000150:complications / Q000503:physiopathology / Q000628:therapy
keywords: Blood–brain barrier; Brain diseases; Functional neuroimaging; Renal insufficiency; Signal transduction