title: [Using mFISH and mBAND for Bioindication of Internal α-Radiation].
abstract: This study was aimed to compare mFISH and mBAND techniques in assessment of the yield of chromosomal aberrations induced by high-LET ionizing radiation. The study group included Mayak workers (46 individuals), for whom the yield of chromosomal aberrations was assessed using two methods: mFISH and mBAND. It was shown that both methods are applicable for biological indication of internal α-radiation exposure. Nevertheless, in case when the source of ionizing radiation is unknown or in terms of a mixed exposure, mFISH appeared as more informative technique that allows identification of markers both external γ-rays (translocations) and internal α-radiation (complex chromosomal rearrangements).
authors.forename: N V
authors.initials: NV
authors.lastname: Sotnik
authors.forename: T V
authors.initials: TV
authors.lastname: Azizova
mesh_terms: D000512:Alpha Particles; D002869:Chromosome Aberrations / Q000528:radiation effects*; D002871:Chromosome Banding / Q000379:methods*; D005720:Gamma Rays; D006801:Humans; D017404:In Situ Hybridization, Fluorescence / Q000379:methods; D016273:Occupational Exposure; D011005:Plutonium; D011839:Radiation, Ionizing
chemical_list: D011005:Plutonium