title: Case Report: Epstein-Barr-Virus negative diffuse large B-cell lymphoma detected in a peri-prosthetic membrane.
abstract: BACKGROUND
  Primary bone lymphomas (PBL) are extremely rare malignant neoplasms. The most commonly described subtype of PBL is diffuse large B-cell lymphoma (DLBCL). DLBCL within peri-prosthetic membrane of a joint is exceedingly rare. To the best of our knowledge this case is the second reported Epstein-Bar-Virus (EBV) negative DLBCL in a peri-prosthetic membrane in the literature.
  
  
  METHODS
  We report an 80 year old female patient who developed a DLBCL with chronic inflammation in association to a metallic implant in the left knee. This lymphoma in contrast to the usually described DLBCL in the peri-prosthetic membrane was EBV negative by EBER in situ hybridization as well as by polymerase chain reaction (PCR).
  
  
  CONCLUSIONS
  This report challenges the concept of DLBCL associated with chronic inflammation and raises the question of other pathogenetic factors involved in the pathogenesis of this rare disease.
authors.affiliation: Institute of Pathology, Medical University of Graz, Graz, Austria.
authors.forename: Sandra
authors.initials: S
authors.lastname: Sunitsch
authors.affiliation: Department of Orthopedics and Orthopedic Surgery, Medical University of Graz, Graz, Austria.
authors.forename: Magdalena
authors.initials: M
authors.lastname: Gilg
authors.affiliation: Institute of Pathology, Medical University of Graz, Graz, Austria.
authors.forename: Karl
authors.initials: K
authors.lastname: Kashofer
authors.affiliation: Department of Orthopedics and Orthopedic Surgery, Medical University of Graz, Graz, Austria.
authors.forename: Andreas
authors.initials: A
authors.lastname: Leithner
authors.affiliation: Institute of Pathology, Medical University of Graz, Graz, Austria. bernadette.liegl-atzwanger@medunigraz.at.
authors.forename: Bernadette
authors.initials: B
authors.lastname: Liegl-Atzwanger
authors.affiliation: Institute of Pathology, Medical University of Graz, Graz, Austria.
authors.forename: Christine
authors.initials: C
authors.lastname: Beham-Schmid
mesh_terms: D000369:Aged, 80 and over; D019645:Arthroplasty, Replacement, Knee / Q000009:adverse effects* / Q000295:instrumentation*; D014408:Biomarkers, Tumor / Q000032:analysis; D001706:Biopsy; D059248:Chemoradiotherapy; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007720:Knee Prosthesis; D016403:Lymphoma, Large B-Cell, Diffuse / Q000737:chemistry / Q000209:etiology* / Q000473:pathology / Q000628:therapy; D008670:Metals; D011474:Prosthesis Design; D011475:Prosthesis Failure; D012307:Risk Factors; D016896:Treatment Outcome
chemical_list: D014408:Biomarkers, Tumor; D008670:Metals
keywords: Diffuse large B-cell lymphoma; Epstein-Barr-Virus negative; Knee arthroplasty; Peri-prosthetic membrane; Primary bone lymphoma