title: Insulin Secretory Capacity and Insulin Resistance in Korean Type 2 Diabetes Mellitus Patients.
abstract: It is well known that many Korean patients with type 2 diabetes mellitus (T2DM) were non-obese and had decreased insulin secretion in past. However, during the past three decades, lifestyles in Korea have been westernized. As a result, the prevalence of obesity, the main cause of diabetes has increased. Thus, there is still a question as to whether the main pathophysiology of current Korean T2DM is insulin resistance or an insulin secretion defect. Because various anti-diabetes medications having different mechanisms of action are currently used as therapeutics, it is important to understand which of these factors is the main physiology in the development of diabetes in Koreans. In this review, we review changes in obesity prevalence, insulin resistance and insulin secretion defects in Korean T2DM during three decades.
authors.affiliation: Division of Endocrinology and Metabolism, Department of Internal Medicine, Konyang University Hospital, Konyang University College of Medicine, Daejeon, Korea.
authors.forename: Jong Dai
authors.identifier: http://orcid.org/0000-0002-2606-3646
authors.initials: JD
authors.lastname: Kim
authors.affiliation: Division of Endocrinology and Metabolism, Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea. wonyoung2.lee@samsung.com.
authors.forename: Won Young
authors.identifier: http://orcid.org/0000-0002-1082-7592
authors.initials: WY
authors.lastname: Lee
keywords: Asian continental ancestry group; Diabetes mellitus, type 2; Insulin resistance