title: Multiplex bioassays encoded by photonic crystal beads and SERS nanotags.
abstract: Multiplex bioassays have drawn more and more attention for the development of novel analytical techniques. Herein, we used photonic crystal (PC) and surface enhanced Raman scattering (SERS) as two encoding elements in different modes for the dual encoding of multiplex bioassays. In practice, PC beads and SERS nanotags act as carriers and labels, respectively, for the multiplex detection of antigens in a sandwich format. Except for the amplified capacity by two encoding modes, we also demonstrated that fine stability, low background and high sensitivity were realized for the quantitative analysis of multiple analytes, which holds great promise in biomedical applications like protein biomarker analysis.
authors.affiliation: State Key Laboratory of Bioelectronics, School of Biological Science and Medical Engineering, Southeast University, Nanjing 210096, China and Laboratory of Environment and biosafety, Research Institute of Southeast University in Suzhou, Suzhou 215123, China. xwzhao@seu.edu.cn fudegang@seu.edu.cn gu@seu.edu.cn.
authors.forename: Bing
authors.initials: B
authors.lastname: Liu
authors.affiliation: State Key Laboratory of Bioelectronics, School of Biological Science and Medical Engineering, Southeast University, Nanjing 210096, China and Laboratory of Environment and biosafety, Research Institute of Southeast University in Suzhou, Suzhou 215123, China. xwzhao@seu.edu.cn fudegang@seu.edu.cn gu@seu.edu.cn.
authors.forename: Xiangwei
authors.initials: X
authors.lastname: Zhao
authors.affiliation: State Key Laboratory of Bioelectronics, School of Biological Science and Medical Engineering, Southeast University, Nanjing 210096, China and Laboratory of Environment and biosafety, Research Institute of Southeast University in Suzhou, Suzhou 215123, China. xwzhao@seu.edu.cn fudegang@seu.edu.cn gu@seu.edu.cn.
authors.forename: Wen
authors.initials: W
authors.lastname: Jiang
authors.affiliation: State Key Laboratory of Bioelectronics, School of Biological Science and Medical Engineering, Southeast University, Nanjing 210096, China and Laboratory of Environment and biosafety, Research Institute of Southeast University in Suzhou, Suzhou 215123, China. xwzhao@seu.edu.cn fudegang@seu.edu.cn gu@seu.edu.cn.
authors.forename: Degang
authors.initials: D
authors.lastname: Fu
authors.affiliation: State Key Laboratory of Bioelectronics, School of Biological Science and Medical Engineering, Southeast University, Nanjing 210096, China and Laboratory of Environment and biosafety, Research Institute of Southeast University in Suzhou, Suzhou 215123, China. xwzhao@seu.edu.cn fudegang@seu.edu.cn gu@seu.edu.cn.
authors.forename: Zhongze
authors.initials: Z
authors.lastname: Gu