title: Hemozoin detection may provide an inexpensive, sensitive, 1-minute malaria test that could revolutionize malaria screening.
abstract: Malaria remains widespread throughout the tropics and is a burden to the estimated 3.5 billion people who are exposed annually. The lack of a fast and accurate diagnostic method contributes to preventable malaria deaths and its continued transmission. In many areas diagnosis is made solely based on clinical presentation. Current methods for malaria diagnosis take more than 20 minutes from the time blood is drawn and are frequently inaccurate. The introduction of an accurate malaria diagnostic that can provide a result in less than 1 minute would allow for widespread screening and treatment of endemic populations, and enable regions that have gained a foothold against malaria to prevent its return. Using malaria parasites' waste product, hemozoin, as a biomarker for the presence of malaria could be the tool needed to develop this rapid test.
authors.affiliation: a School of Medicine - Center for Global Health and Diseases , Case Western Reserve University , Cleveland , OH , USA.
authors.forename: Brian T
authors.initials: BT
authors.lastname: Grimberg
authors.affiliation: b School of Medicine, Department of Radiology , Case Western Reserve University , Cleveland , OH , USA.
authors.forename: Kerry O
authors.initials: KO
authors.lastname: Grimberg
mesh_terms: D015415:Biomarkers / Q000097:blood; D006420:Hemeproteins / Q000032:analysis*; D006801:Humans; D008288:Malaria / Q000097:blood / Q000175:diagnosis* / Q000469:parasitology; D008403:Mass Screening; D012680:Sensitivity and Specificity
chemical_list: D015415:Biomarkers; D006420:Hemeproteins; C020753:hemozoin
keywords: Magneto-Optical Detection; Malaria; RDT; elimination; hemozoin; rapid diagnostic