title: Association of pretreatment body mass index and survival in human papillomavirus positive oropharyngeal squamous cell carcinoma.
abstract: Pretreatment body mass index (BMI) >25kg/m(2) is a positive prognostic factor in patients with head and neck cancer. Previous studies have not been adequately stratified by human papilloma virus (HPV) status or subsite. Our objective is to determine prognostic significance of pretreatment BMI on overall survival in HPV+ oropharyngeal squamous cell carcinoma (OPSCC).
  
  
  
  This is a retrospective review of patients with HPV+ OPSCC treated between 8/1/2006 and 8/31/2014. Patients were stratified by BMI status (>/<25kg/m(2)). Univariate and multivariate analyses of survival were performed.
  
  
  
  300 patients met our inclusion/exclusion criteria. Patients with a BMI >25kg/m(2) had a longer overall survival (HR=0.49, P=0.01) as well as a longer disease-specific survival (HR=0.43, P=0.02). Overall survival remained significantly associated with high BMI on multivariate analysis (HR=0.54, P=0.04).
  
  
  
  Pre-treatment normal or underweight BMI status is associated with worse overall survival in HPV+ OPSCC.
authors.affiliation: Department of Otolaryngology - Head and Neck Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA, United States. Electronic address: albergottiwg@upmc.edu.
authors.forename: William G
authors.initials: WG
authors.lastname: Albergotti
authors.affiliation: Department of Otolaryngology - Head and Neck Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA, United States.
authors.forename: Kara S
authors.initials: KS
authors.lastname: Davis
authors.affiliation: Biostatistics Facility, University of Pittsburgh Cancer Institute, Pittsburgh, PA, United States.
authors.forename: Shira
authors.initials: S
authors.lastname: Abberbock
authors.affiliation: Division Medical Oncology, Department of Medicine, University of Pittsburgh, Pittsburgh, PA, United States.
authors.forename: Julie E
authors.initials: JE
authors.lastname: Bauman
authors.affiliation: Division Medical Oncology, Department of Medicine, University of Pittsburgh, Pittsburgh, PA, United States.
authors.forename: James
authors.initials: J
authors.lastname: Ohr
authors.affiliation: Department of Radiation Oncology, University of Pittsburgh Cancer Institute, Pittsburgh, PA, United States.
authors.forename: David A
authors.initials: DA
authors.lastname: Clump
authors.affiliation: Department of Otolaryngology - Head and Neck Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA, United States; Department of Radiation Oncology, University of Pittsburgh Cancer Institute, Pittsburgh, PA, United States.
authors.forename: Dwight E
authors.initials: DE
authors.lastname: Heron
authors.affiliation: Veterans Affairs Pittsburgh Health System, Pittsburgh, PA, United States; Department of Otolaryngology - Head and Neck Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA, United States.
authors.forename: Umamaheswar
authors.initials: U
authors.lastname: Duvvuri
authors.affiliation: Department of Otolaryngology - Head and Neck Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA, United States.
authors.forename: Seungwon
authors.initials: S
authors.lastname: Kim
authors.affiliation: Department of Otolaryngology - Head and Neck Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA, United States.
authors.forename: Jonas T
authors.initials: JT
authors.lastname: Johnson
authors.affiliation: Department of Otolaryngology - Head and Neck Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA, United States.
authors.forename: Robert L
authors.initials: RL
authors.lastname: Ferris
mesh_terms: D000328:Adult; D000368:Aged; D052685:Alphapapillomavirus / Q000302:isolation & purification*; D015992:Body Mass Index; D002294:Carcinoma, Squamous Cell / Q000473:pathology* / Q000601:surgery / Q000821:virology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009959:Oropharyngeal Neoplasms / Q000473:pathology* / Q000601:surgery / Q000821:virology; D057234:Preoperative Period; D012189:Retrospective Studies; D016019:Survival Analysis; D055815:Young Adult
keywords: Body mass index; Human papillomavirus; Oropharyngeal squamous cell carcinoma; Survival