title: Clusters of male and female Alzheimer's disease patients in the Alzheimer's Disease Neuroimaging Initiative (ADNI) database.
abstract: This paper presents homogeneous clusters of patients, identified in the Alzheimer's Disease Neuroimaging Initiative (ADNI) data population of 317 females and 342 males, described by a total of 243 biological and clinical descriptors. Clustering was performed with a novel methodology, which supports identification of patient subpopulations that are homogeneous regarding both clinical and biological descriptors. Properties of the constructed clusters clearly demonstrate the differences between female and male Alzheimer's disease patient groups. The major difference is the existence of two male subpopulations with unexpected values of intracerebral and whole brain volumes.
authors.affiliation: Ruđer Bošković Institute, Zagreb, Croatia.
authors.forename: Dragan
authors.initials: D
authors.lastname: Gamberger
authors.affiliation: Jožef Stefan Institute, Ljubljana, Slovenia.
authors.forename: Bernard
authors.initials: B
authors.lastname: Ženko
authors.affiliation: Tel Aviv University, Tel Aviv, Israel.
authors.forename: Alexis
authors.initials: A
authors.lastname: Mitelpunkt
authors.affiliation: Tel Aviv University, Tel Aviv, Israel.
authors.forename: Netta
authors.initials: N
authors.lastname: Shachar
authors.affiliation: Jožef Stefan Institute, Ljubljana, Slovenia ; University of Nova Gorica, Nova Gorica, Slovenia.
authors.forename: Nada
authors.initials: N
authors.lastname: Lavrač
keywords: Alzheimer’s disease; Clustering; Female and male subpopulations