title: IRE1 Sulfenylation by Reactive Oxygen Species Coordinates Cellular Stress Signaling.
abstract: In this issue of Molecular Cell, Hourihan et al. (2016) show that sulfenylation of IRE1 by reactive oxygen species inhibits the role of IRE1 in the Unfolded Protein Response and activates a SKN-1/Nrf2-dependent response to oxidative stress.
authors.affiliation: Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. Electronic address: dhkim@mit.edu.
authors.forename: Dennis H
authors.initials: DH
authors.lastname: Kim
mesh_terms: D018384:Oxidative Stress; D017346:Protein Serine-Threonine Kinases / Q000235:genetics; D017382:Reactive Oxygen Species; D015398:Signal Transduction; D056811:Unfolded Protein Response
chemical_list: D017382:Reactive Oxygen Species; D017346:Protein Serine-Threonine Kinases