title: Diagnostic Potential of Evaluation of SDF-1α and sRAGE Levels in Threatened Premature Labor.
abstract: Preterm birth remains the most prevalent cause of neonatal morbidity. This study aimed to evaluate the diagnostic value of SDF-1α, resistin, secretory RAGE (sRAGE), and endogenous secretory RAGE (esRAGE) in preterm labor. A total of 211 pregnant women participated in the study. Group A contained 72 women between 22 and 36 weeks of gestation, with premature labor, who finally had preterm birth. Group B contained 66 women in labor between 37 and 41 weeks of gestation. Women in group A had lower SDF-1α and sRAGE levels than those in group B. Moreover, in group A, SDF-1α and sRAGE levels were correlated with the latency period from the occurrence of premature labor symptoms until delivery. Sensitivity and specificity of studied parameters for prediction of preterm birth were 95% and 40% for SDF-1α and 51.3% and 93.5% for sRAGE, respectively. The prognostic value of plasma SDF-1α and sRAGE levels was comparable with that of cervical length ultrasound measurement and serum C-reactive protein levels. We conclude that SDF-1α and sRAGE appear to play a major role in the diagnosis of preterm birth and its evaluation could be convenient and useful for predicting preterm birth.
authors.affiliation: Department of Obstetrics and Gynecology, Pomeranian Medical University, Ulica Powstańców Wielkopolskich 72, 70-111 Szczecin, Poland.
authors.forename: Rafał
authors.identifier: 0000-0002-9294-1005
authors.initials: R
authors.lastname: Rzepka
authors.affiliation: Department of Laboratory Diagnostics and Molecular Medicine, Pomeranian Medical University, Ulica Powstańców Wielkopolskich 72, 70-111 Szczecin, Poland.
authors.forename: Barbara
authors.identifier: 0000-0003-3138-1013
authors.initials: B
authors.lastname: Dołęgowska
authors.affiliation: Department of Obstetrics and Gynecology, Pomeranian Medical University, Ulica Powstańców Wielkopolskich 72, 70-111 Szczecin, Poland.
authors.forename: Aleksandra
authors.initials: A
authors.lastname: Rajewska
authors.affiliation: Department of Laboratory Diagnostics and Molecular Medicine, Pomeranian Medical University, Ulica Powstańców Wielkopolskich 72, 70-111 Szczecin, Poland.
authors.forename: Daria
authors.identifier: 0000-0002-9851-5680
authors.initials: D
authors.lastname: Sałata
authors.affiliation: Department of Laboratory Diagnostics and Molecular Medicine, Pomeranian Medical University, Ulica Powstańców Wielkopolskich 72, 70-111 Szczecin, Poland.
authors.forename: Marta
authors.initials: M
authors.lastname: Budkowska
authors.affiliation: Department of Obstetrics and Gynecology, Pomeranian Medical University, Ulica Powstańców Wielkopolskich 72, 70-111 Szczecin, Poland.
authors.forename: Sebastian
authors.initials: S
authors.lastname: Kwiatkowski
authors.affiliation: Department of Obstetrics and Gynecology, Pomeranian Medical University, Ulica Powstańców Wielkopolskich 72, 70-111 Szczecin, Poland.
authors.forename: Andrzej
authors.initials: A
authors.lastname: Torbé
mesh_terms: D000328:Adult; D002097:C-Reactive Protein / Q000378:metabolism; D016022:Case-Control Studies; D054377:Chemokine CXCL12 / Q000097:blood*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007752:Obstetric Labor, Premature / Q000097:blood* / Q000175:diagnosis*; D011247:Pregnancy; D012372:ROC Curve; D000067759:Receptor for Advanced Glycation End Products / Q000097:blood*
chemical_list: C000593871:AGER protein, human; C515255:CXCL12 protein, human; D054377:Chemokine CXCL12; D000067759:Receptor for Advanced Glycation End Products; D002097:C-Reactive Protein