title: No Effect of Anodal Transcranial Direct Current Stimulation Over the Motor Cortex on Response-Related ERPs during a Conflict Task.
abstract: Anodal transcranial direct current stimulation (tDCS) over the motor cortex is considered a potential treatment for motor rehabilitation following stroke and other neurological pathologies. However, both the context under which this stimulation is effective and the underlying mechanisms remain to be determined. In this study, we examined the mechanisms by which anodal tDCS may affect motor performance by recording event-related potentials (ERPs) during a cued go/nogo task after anodal tDCS over dominant primary motor cortex (M1) in young adults (Experiment 1) and both dominant and non-dominant M1 in older adults (Experiment 2). In both experiments, anodal tDCS had no effect on either response time (RT) or response-related ERPs, including the cue-locked contingent negative variation (CNV) and both target-locked and response-locked lateralized readiness potentials (LRP). Bayesian model selection analyses showed that, for all measures, the null effects model was stronger than a model including anodal tDCS vs. sham. We conclude that anodal tDCS has no effect on RT or response-related ERPs during a cued go/nogo task in either young or older adults.
authors.affiliation: Functional Neuroimaging Laboratory, School of Psychology, Faculty of Science and IT, University of NewcastleNewcastle, NSW, Australia; Priority Research Centre for Stroke and Brain Injury, University of NewcastleNewcastle, NSW, Australia; Hunter Medical Research InstituteNewcastle, NSW, Australia.
authors.forename: Alexander C
authors.initials: AC
authors.lastname: Conley
authors.affiliation: Functional Neuroimaging Laboratory, School of Psychology, Faculty of Science and IT, University of NewcastleNewcastle, NSW, Australia; Priority Research Centre for Stroke and Brain Injury, University of NewcastleNewcastle, NSW, Australia; Hunter Medical Research InstituteNewcastle, NSW, Australia.
authors.forename: W R
authors.initials: WR
authors.lastname: Fulham
authors.affiliation: Priority Research Centre for Stroke and Brain Injury, University of NewcastleNewcastle, NSW, Australia; Hunter Medical Research InstituteNewcastle, NSW, Australia; School of Health Sciences, Faculty of Health, University of NewcastleNewcastle, NSW, Australia.
authors.forename: Jodie L
authors.initials: JL
authors.lastname: Marquez
authors.affiliation: Priority Research Centre for Stroke and Brain Injury, University of NewcastleNewcastle, NSW, Australia; Hunter Medical Research InstituteNewcastle, NSW, Australia; School of Medicine and Public Health, Faculty of Health, University of NewcastleNewcastle, NSW, Australia.
authors.forename: Mark W
authors.initials: MW
authors.lastname: Parsons
authors.affiliation: Functional Neuroimaging Laboratory, School of Psychology, Faculty of Science and IT, University of NewcastleNewcastle, NSW, Australia; Priority Research Centre for Stroke and Brain Injury, University of NewcastleNewcastle, NSW, Australia; Hunter Medical Research InstituteNewcastle, NSW, Australia.
authors.forename: Frini
authors.initials: F
authors.lastname: Karayanidis
keywords: P300; ageing; contingent negative variation; event-related potential; lateralized readiness potential; transcranial direct current stimulation