title: Internal Limiting Membrane Peeling to Prevent Post-vitrectomy Epiretinal Membrane Development in Retinal Detachment.
abstract: OBJECTIVE
  To determine the efficacy of internal limiting membrane (ILM) peeling during vitrectomy for rhegmatogenous retinal detachment (RRD) regarding post-vitrectomy epiretinal membrane (ERM) development and visual outcomes.
  
  
  METHODS
  Retrospective, interventional, comparative case series.
  
  
  METHODS
  Setting: Institutional.
  
  
  METHODS
  One hundred and two consecutive eyes with RRD treated with vitrectomy and followed for at least 6 months. ILM was peeled without using dye such as indocyanine green (ICG). Observational Procedures: Patients were divided into 2 groups based on postoperative ERM development: Group 1, 81 eyes without ERM formation; Group 2, 21 eyes with ERM development. Patients also were divided into 2 subgroups: those with and without ILM peeling (58 and 44 eyes, respectively). Statistical analyses were performed between the 2 groups with/without ERM formation and between the 2 subgroups with/without ILM peeling for 5 preoperative factors including foveal involvement of the RRD, 4 intraoperative factors including ILM peeling, baseline best-corrected visual acuity (BCVA), and final BCVA.
  
  
  METHODS
  An association of ILM peeling with ERM prevention and the influence of ILM peeling on visual outcomes.
  
  
  RESULTS
  ILM peeling was significantly (P < .001) associated with ERM prevention. There was no significant difference in the final BCVA between subgroups with and without ILM peeling.
  
  
  CONCLUSIONS
  ILM peeling without ICG staining during the initial vitrectomy for RRDs may prevent postoperative ERM formation with favorable visual outcomes.
authors.affiliation: Department of Ophthalmology, National Hospital Organization, Tokyo Medical Center, Tokyo, Japan; Laboratory of Visual Physiology, Division of Vision Research, National Institute of Sensory Organs, National Hospital Organization, Tokyo Medical Center, Tokyo, Japan. Electronic address: kakiyama@ntmc-hosp.jp.
authors.forename: Kunihiko
authors.initials: K
authors.lastname: Akiyama
authors.affiliation: Department of Ophthalmology, National Hospital Organization, Tokyo Medical Center, Tokyo, Japan; Laboratory of Visual Physiology, Division of Vision Research, National Institute of Sensory Organs, National Hospital Organization, Tokyo Medical Center, Tokyo, Japan; Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan; UCL Institute of Ophthalmology, London, United Kingdom.
authors.forename: Kaoru
authors.initials: K
authors.lastname: Fujinami
authors.affiliation: Department of Ophthalmology, National Hospital Organization, Tokyo Medical Center, Tokyo, Japan; Laboratory of Visual Physiology, Division of Vision Research, National Institute of Sensory Organs, National Hospital Organization, Tokyo Medical Center, Tokyo, Japan.
authors.forename: Ken
authors.initials: K
authors.lastname: Watanabe
authors.affiliation: Department of Ophthalmology, National Hospital Organization, Tokyo Medical Center, Tokyo, Japan; Laboratory of Visual Physiology, Division of Vision Research, National Institute of Sensory Organs, National Hospital Organization, Tokyo Medical Center, Tokyo, Japan.
authors.forename: Kazushige
authors.initials: K
authors.lastname: Tsunoda
authors.affiliation: Department of Ophthalmology, National Hospital Organization, Tokyo Medical Center, Tokyo, Japan.
authors.forename: Toru
authors.initials: T
authors.lastname: Noda
mesh_terms: D001485:Basement Membrane / Q000601:surgery*; D019773:Epiretinal Membrane / Q000175:diagnosis / Q000209:etiology / Q000517:prevention & control*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000175:diagnosis / Q000209:etiology / Q000517:prevention & control*; D012163:Retinal Detachment / Q000175:diagnosis / Q000601:surgery*; D012189:Retrospective Studies; D041623:Tomography, Optical Coherence; D016896:Treatment Outcome; D014792:Visual Acuity; D014821:Vitrectomy / Q000009:adverse effects*