title: Differential Releases of Dopamine and Neuropeptide Y from Histamine-Stimulated PC12 Cells Detected by an Aptamer-Modified Nanowire Transistor.
abstract: Silicon nanowire field-effect transistors modified with specific aptamers can directly detect the minute dopamine and neuropeptide Y released from cells. The binding of these molecules to the aptamers results in a conductance change of the transistor biosensor and illustrates the differential releasing mechanisms of these molecules stored in various vesicle pools.
authors.affiliation: Department of Chemistry, National Taiwan University, No. 1, Sec. 4, Roosevelt Road, Taipei, 106, Taiwan.|Institute of Atomic and Molecular Sciences, Academia Sinica, P.O. Box 23-166, Taipei, 106, Taiwan.|Department of Life Science, National Taiwan University, No. 1, Sec. 4, Roosevelt Road, Taipei, 106, Taiwan.
authors.forename: Subhasree
authors.initials: S
authors.lastname: Banerjee
authors.affiliation: Department of Chemistry, National Taiwan University, No. 1, Sec. 4, Roosevelt Road, Taipei, 106, Taiwan.
authors.forename: Ying-Jhu
authors.initials: YJ
authors.lastname: Hsieh
authors.affiliation: Department of Chemistry, National Taiwan University, No. 1, Sec. 4, Roosevelt Road, Taipei, 106, Taiwan.
authors.forename: Chia-Rung
authors.initials: CR
authors.lastname: Liu
authors.affiliation: Department of Life Science, National Taiwan University, No. 1, Sec. 4, Roosevelt Road, Taipei, 106, Taiwan.
authors.forename: Nai-Hsing
authors.initials: NH
authors.lastname: Yeh
authors.affiliation: Department of Life Science, National Taiwan University, No. 1, Sec. 4, Roosevelt Road, Taipei, 106, Taiwan.
authors.forename: Hui-Hsing
authors.initials: HH
authors.lastname: Hung
authors.affiliation: Department of Chemistry, National Taiwan University, No. 1, Sec. 4, Roosevelt Road, Taipei, 106, Taiwan.
authors.forename: Yew-Seng
authors.initials: YS
authors.lastname: Lai
authors.affiliation: Department of Life Science, National Taiwan University, No. 1, Sec. 4, Roosevelt Road, Taipei, 106, Taiwan.
authors.forename: Ai-Chuan
authors.initials: AC
authors.lastname: Chou
authors.affiliation: Department of Chemistry, National Taiwan University, No. 1, Sec. 4, Roosevelt Road, Taipei, 106, Taiwan. ytcchem@ntu.edu.tw.|Institute of Atomic and Molecular Sciences, Academia Sinica, P.O. Box 23-166, Taipei, 106, Taiwan. ytcchem@ntu.edu.tw.
authors.forename: Yit-Tsong
authors.initials: YT
authors.lastname: Chen
authors.affiliation: Department of Life Science, National Taiwan University, No. 1, Sec. 4, Roosevelt Road, Taipei, 106, Taiwan. cypan@ntu.edu.tw.
authors.forename: Chien-Yuan
authors.initials: CY
authors.lastname: Pan
mesh_terms: D000818:Animals; D052158:Aptamers, Peptide / Q000737:chemistry*; D004298:Dopamine / Q000032:analysis*; D006632:Histamine / Q000494:pharmacology*; D053770:Nanowires / Q000737:chemistry*; D009478:Neuropeptide Y / Q000032:analysis*; D016716:PC12 Cells; D051381:Rats; D012825:Silicon / Q000737:chemistry; D014173:Transistors, Electronic
chemical_list: D052158:Aptamers, Peptide; D009478:Neuropeptide Y; D006632:Histamine; D004298:Dopamine; D012825:Silicon
keywords: dopamine; histamine; large dense-core vesicles; neuropeptide Y; silicon nanowire field-effect transistors