title: Gene polymorphisms as a predictor of body weight loss after Roux-en-Y gastric bypass surgery among obese women.
abstract: This study aimed to investigate the association between twelve gene polymorphisms and body weight loss, 12 months after Roux-en-Y gastric bypass (RYGB) surgery. Three hundred and fifty-one obese women participated in this study. The statistical software WEKA was used to identify which gene polymorphisms were potential predictors of postoperative percentage of excess weight loss (%EWL). Our results indicate that the only gene polymorphism that predicted %EWL was rs3813929, which is related to the serotonin receptor gene (5-HT2C). Therefore, the 5-HT2C gene polymorphism rs3813929 (more specifically, the TT genotype) predicted greater %EWL 12 months after RYGB surgery among female patients.
authors.affiliation: Post-graduate Program in Food and Nutrition, São Paulo State University (UNESP), Araraquara, SP, Brazil.
authors.forename: Patrícia Fátima Souza
authors.initials: PF
authors.lastname: Novais
authors.affiliation: Post-graduate Program in Food and Nutrition, São Paulo State University (UNESP), Araraquara, SP, Brazil; Institute of Biosciences, São Paulo State University (UNESP), Botucatu, SP, Brazil.
authors.forename: Thabata Koester
authors.initials: TK
authors.lastname: Weber
authors.affiliation: Institute of Biosciences, São Paulo State University (UNESP), Botucatu, SP, Brazil.
authors.forename: Ney
authors.initials: N
authors.lastname: Lemke
authors.affiliation: Post-graduate Program in Human Movement Sciences, Methodist University of Piracicaba (UNIMEP), Piracicaba, SP, Brazil.
authors.forename: Rozangela
authors.initials: R
authors.lastname: Verlengia
authors.affiliation: Post-graduate Program in Food and Nutrition, São Paulo State University (UNESP), Araraquara, SP, Brazil. Electronic address: alexharleycrisp@gmail.com.
authors.forename: Alex Harley
authors.initials: AH
authors.lastname: Crisp
authors.affiliation: Clínica Bariátrica, Piracicaba, SP, Brazil.
authors.forename: Irineu
authors.initials: I
authors.lastname: Rasera-Junior
authors.affiliation: Post-graduate Program in Food and Nutrition, São Paulo State University (UNESP), Araraquara, SP, Brazil; Institute of Biosciences, São Paulo State University (UNESP), Botucatu, SP, Brazil. Electronic address: mrmolive@ibb.unesp.br.
authors.forename: Maria Rita Marques
authors.initials: MR
authors.lastname: de Oliveira
mesh_terms: D000328:Adult; D000483:Alleles; D005260:Female; D015390:Gastric Bypass; D005838:Genotype; D006801:Humans; D008875:Middle Aged; D009765:Obesity / Q000235:genetics / Q000601:surgery; D009767:Obesity, Morbid / Q000235:genetics* / Q000601:surgery; D011110:Polymorphism, Genetic; D044405:Receptor, Serotonin, 5-HT2C / Q000235:genetics*; D012189:Retrospective Studies; D015431:Weight Loss / Q000235:genetics*; D055815:Young Adult
chemical_list: D044405:Receptor, Serotonin, 5-HT2C
keywords: Bariatric surgery; Gene polymorphism; Obesity; Weight loss