title: Long-Term Cognitive Outcomes of Birth Asphyxia and the Contribution of Identified Perinatal Asphyxia to Cerebral Palsy.
abstract: Neonatal encephalopathy among survivors of presumed perinatal asphyxia is recognized as an important cause of cerebral palsy (CP) and neuromotor impairment. Recent studies suggest that moderate to severe neonatal encephalopathy contributes to a wide range of neurodevelopmental and cognitive impairments among survivors with and without CP. Nearly 1 of every 4 to 5 neonates treated with hypothermia has or develops CP. Neonatal encephalopathy is diagnosed in only approximately 10% of all cases. This article reviews the long-term cognitive outcomes of children with presumed birth asphyxia and describes what is known about its contribution to CP.
authors.affiliation: Department of Pediatrics, St. John Hospital and Medical Center, NICU CCB-5, Wayne State University School of Medicine, 22101 Moross, Detroit, MI 48236, USA. Electronic address: apappas@med.wayne.edu.
authors.forename: Athina
authors.initials: A
authors.lastname: Pappas
authors.affiliation: Hutzel Women's Hospital, Perinatology Research Branch (NICHD/NIH), 4 Brush - Office 4817, 3990 John R. Street, Detroit, MI 48201, USA.
authors.forename: Steven J
authors.initials: SJ
authors.lastname: Korzeniewski
mesh_terms: D001238:Asphyxia Neonatorum / Q000453:epidemiology / Q000503:physiopathology*; D002547:Cerebral Palsy / Q000453:epidemiology / Q000503:physiopathology*; D060825:Cognitive Dysfunction / Q000453:epidemiology / Q000503:physiopathology*; D005260:Female; D006801:Humans; D020925:Hypoxia-Ischemia, Brain / Q000453:epidemiology / Q000503:physiopathology*; D007231:Infant, Newborn; D011247:Pregnancy; D012720:Severity of Illness Index
keywords: Cerebral palsy; Cognitive outcome; Hypoxic ischemic encephalopathy; Neonatal encephalopathy; Newborn