title: Serum vitamin D level is negatively associated with carotid atherosclerosis in Korean adults.
abstract: The present study investigated the associations between serum vitamin D levels and carotid intima-media thickness (CIMT), carotid plaque and atherosclerosis in 71 Korean adults. CIMT and the presence of carotid plaque were assessed with a high-resolution B-mode ultrasound system, and carotid atherosclerosis was defined as a mean CIMT value >0.9 mm or the presence of carotid plaque. A vitamin D deficiency was associated with the presence of carotid plaque (adjusted odds ratio [aOR]: 9.25, 95% confidence interval [CI]: 1.52-56.3; p = 0.016). As serum vitamin D levels increased, the presence of high-risk carotid plaque decreased (aOR: 0.84, 95%CI: 0.72-0.99; p = 0.039). Serum vitamin D levels was negatively associated with carotid atherosclerosis (aOR: 0.86, 95%CI: 0.76-0.97; p = 0.018). Further studies are needed to investigate whether vitamin D supplementation would be effective for the prevention of atherosclerosis and cardiovascular diseases.
authors.affiliation: a Department of Family Medicine , St. Vincent's Hospital, College of Medicine, the Catholic University of Korea , Seoul , Republic of Korea.
authors.forename: Yeon-Kyeong
authors.initials: YK
authors.lastname: Choi
authors.affiliation: a Department of Family Medicine , St. Vincent's Hospital, College of Medicine, the Catholic University of Korea , Seoul , Republic of Korea.
authors.forename: Sang-Wook
authors.initials: SW
authors.lastname: Song
authors.affiliation: a Department of Family Medicine , St. Vincent's Hospital, College of Medicine, the Catholic University of Korea , Seoul , Republic of Korea.
authors.forename: Bo-Ra
authors.initials: BR
authors.lastname: Shin
authors.affiliation: a Department of Family Medicine , St. Vincent's Hospital, College of Medicine, the Catholic University of Korea , Seoul , Republic of Korea.
authors.forename: Jeong-Ah
authors.initials: JA
authors.lastname: Kim
authors.affiliation: a Department of Family Medicine , St. Vincent's Hospital, College of Medicine, the Catholic University of Korea , Seoul , Republic of Korea.
authors.forename: Ha-Na
authors.initials: HN
authors.lastname: Kim
mesh_terms: D015652:25-Hydroxyvitamin D 2 / Q000097:blood; D050197:Atherosclerosis / Q000000981:diagnostic imaging / Q000453:epidemiology / Q000208:ethnology / Q000209:etiology*; D015415:Biomarkers / Q000097:blood; D002112:Calcifediol / Q000097:blood; D059168:Carotid Intima-Media Thickness; D016893:Carotid Stenosis / Q000000981:diagnostic imaging / Q000453:epidemiology / Q000208:ethnology / Q000209:etiology*; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D016015:Logistic Models; D008297:Male; D008403:Mass Screening; D008875:Middle Aged; D009752:Nutritional Status / Q000208:ethnology; D015995:Prevalence; D056910:Republic of Korea / Q000453:epidemiology; D012307:Risk Factors; D057566:Self Report; D012720:Severity of Illness Index; D014808:Vitamin D Deficiency / Q000097:blood / Q000208:ethnology / Q000503:physiopathology*
chemical_list: D015415:Biomarkers; D015652:25-Hydroxyvitamin D 2; D002112:Calcifediol
keywords: 25-hydroxyvitamin D; Carotid intima-media thickness; carotid plaque; vitamin D deficiency