title: Subthalamic, not striatal, activity correlates with basal ganglia downstream activity in normal and parkinsonian monkeys.
abstract: The striatum and the subthalamic nucleus (STN) constitute the input stage of the basal ganglia (BG) network and together innervate BG downstream structures using GABA and glutamate, respectively. Comparison of the neuronal activity in BG input and downstream structures reveals that subthalamic, not striatal, activity fluctuations correlate with modulations in the increase/decrease discharge balance of BG downstream neurons during temporal discounting classical condition task. After induction of parkinsonism with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), abnormal low beta (8-15 Hz) spiking and local field potential (LFP) oscillations resonate across the BG network. Nevertheless, LFP beta oscillations entrain spiking activity of STN, striatal cholinergic interneurons and BG downstream structures, but do not entrain spiking activity of striatal projection neurons. Our results highlight the pivotal role of STN divergent projections in BG physiology and pathophysiology and may explain why STN is such an effective site for invasive treatment of advanced Parkinson's disease and other BG-related disorders.
authors.affiliation: Department of Medical Neurobiology, Institute of Medical Research Israel-Canada, The Hebrew University-Hadassah Medical School, Jerusalem, Israel.|The Edmond and Lily Safra Center for Brain Sciences, The Hebrew University, Jerusalem, Israel.
authors.forename: Marc
authors.identifier: 0000-0003-0734-6541
authors.initials: M
authors.lastname: Deffains
authors.affiliation: Department of Medical Neurobiology, Institute of Medical Research Israel-Canada, The Hebrew University-Hadassah Medical School, Jerusalem, Israel.|The Edmond and Lily Safra Center for Brain Sciences, The Hebrew University, Jerusalem, Israel.
authors.forename: Liliya
authors.initials: L
authors.lastname: Iskhakova
authors.affiliation: Department of Medical Neurobiology, Institute of Medical Research Israel-Canada, The Hebrew University-Hadassah Medical School, Jerusalem, Israel.
authors.forename: Shiran
authors.initials: S
authors.lastname: Katabi
authors.affiliation: Department of Pharmacology and Physiology, University of Rochester School of Medicine, Rochester, United States.
authors.forename: Suzanne N
authors.initials: SN
authors.lastname: Haber
authors.affiliation: Department of Neurosurgery, Hadassah University Hospital, Jerusalem, Israel.
authors.forename: Zvi
authors.initials: Z
authors.lastname: Israel
authors.affiliation: Department of Medical Neurobiology, Institute of Medical Research Israel-Canada, The Hebrew University-Hadassah Medical School, Jerusalem, Israel.
authors.forename: Hagai
authors.identifier: 0000-0002-2402-6673
authors.initials: H
authors.lastname: Bergman
mesh_terms: D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine / Q000008:administration & dosage; D000200:Action Potentials; D000818:Animals; D001479:Basal Ganglia / Q000502:physiology*; D058256:Brain Waves; D002522:Chlorocebus aethiops; D004195:Disease Models, Animal; D009434:Neural Pathways; D010300:Parkinson Disease / Q000503:physiopathology*; D020531:Subthalamic Nucleus / Q000502:physiology*; D066328:Ventral Striatum / Q000502:physiology
chemical_list: D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
keywords: African vervet green monkey; Basal ganglia; Electrophysiology; Parkinson-s disease; neuroscience