title: Improvement of Triglyceride Levels through the Intake of Enriched-β-Conglycinin Soybean (Nanahomare) Revealed in a Randomized, Double-Blind, Placebo-Controlled Study.
abstract: Soybean is recognized as a beneficial food with various functional components, such as β-conglycinin, which improves lipid metabolism. We evaluated the effects of the β-conglycinin-rich soybean Nanahomare on triglyceride (TG) levels. In this randomized, double-blind, placebo-controlled study, we divided 134 adult subjects into test and placebo groups that consumed processed food containing enriched-β-conglycinin soybean or low-β-conglycinin soybean. Hematological tests and body composition measurements were performed at weeks 0 (baseline), 4, 8, and 12 of the study period. TG levels significantly decreased in the test group compared with the placebo group at weeks 4 (change from baseline to week 4, placebo: 0.27 ± 44.13 mg/dL, test: -20.31 ± 43.74 mg/dL, p = 0.035) and 12 (change from baseline to week 12, placebo: -0.14 ± 65.83 mg/dL, test: -21.30 ± 46.21 mg/dL, p = 0.041). In addition, among subjects whose baseline TG levels were ≥100 mg/dL, the levels significantly improved in the test group at weeks 4 (p = 0.010) and 12 (p = 0.030), whereas the levels were not different between the test and placebo groups among those whose baseline levels were <100 mg/dL. These results suggest that the ingestion of enriched-β-conglycinin soybean improves serum TG levels.
authors.affiliation: Department of Medical Management and Informatics, Hokkaido Information University, Ebetsu, Hokkaido 069-8585, Japan. mnishimura@do-johodai.ac.jp.
authors.forename: Mie
authors.initials: M
authors.lastname: Nishimura
authors.affiliation: Department of Medical Management and Informatics, Hokkaido Information University, Ebetsu, Hokkaido 069-8585, Japan. tatuyao@mail.goo.ne.jp.
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Ohkawara
authors.affiliation: Department of Medical Management and Informatics, Hokkaido Information University, Ebetsu, Hokkaido 069-8585, Japan. ysato@do-johodai.ac.jp.
authors.forename: Yuji
authors.initials: Y
authors.lastname: Sato
authors.affiliation: Department of Medical Management and Informatics, Hokkaido Information University, Ebetsu, Hokkaido 069-8585, Japan. h-satoh@do-johodai.ac.jp.
authors.forename: Hiroki
authors.initials: H
authors.lastname: Satoh
authors.affiliation: Division of Food Function Research, Food Research Institute, NARO, Tsukuba, Ibaraki 305-8642, Japan. youkot@affrc.go.jp.
authors.forename: Yoko
authors.initials: Y
authors.lastname: Takahashi
authors.affiliation: Institute of Crop Science, NARO, Tsukuba, Ibaraki 305-8518, Japan. mhajika@affrc.go.jp.
authors.forename: Makita
authors.initials: M
authors.lastname: Hajika
authors.affiliation: Department of Medical Management and Informatics, Hokkaido Information University, Ebetsu, Hokkaido 069-8585, Japan. nishihira@do-johodai.ac.jp.
authors.forename: Jun
authors.initials: J
authors.lastname: Nishihira
mesh_terms: D000328:Adult; D000368:Aged; D052179:Antigens, Plant / Q000494:pharmacology*; D001823:Body Composition / Q000187:drug effects; D004311:Double-Blind Method; D004435:Eating / Q000502:physiology*; D005260:Female; D005527:Food, Fortified; D005916:Globulins / Q000494:pharmacology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D055314:Seed Storage Proteins / Q000494:pharmacology*; D030262:Soybean Proteins / Q000494:pharmacology*; D013025:Glycine max / Q000737:chemistry*; D013997:Time Factors; D014280:Triglycerides / Q000097:blood*
chemical_list: D052179:Antigens, Plant; D005916:Globulins; D055314:Seed Storage Proteins; D030262:Soybean Proteins; D014280:Triglycerides; C013894:beta-conglycinin protein, Glycine max
keywords: Nanahomare; clinical trial; soybean; triglyceride; β-conglycinin