title: Single Center Prospective Phase II Trial of CT-guided Radiofrequency Ablation for Pulmonary Metastases from Colorectal Cancer (SCIRO-1401).
abstract: The present single center prospective phase II clinical trial is designed to evaluate the efficacy and safety of percutaneous radiofrequency (RF) ablation for colorectal lung metastases. Patients who have colorectal lung metastases without extrapulmonary metastases are included in this study. The primary endpoint is 3-year overall survival (OS) after RF ablation. The secondary endpoints are the prevalence of adverse events within 4 weeks, local tumor progression rate, 1- and 5-year OS, cause-specific survival, and relapse-free survival. The recruitment of patients commenced in July 2014, and the enrolment of 45 patients is intended over the 3 years of study period.
authors.affiliation: Center for Innovative Clinical Medicine, Okayama University Hospital, Okayama 700-8558, Japan.sakurai-jun@okayama-u.ac.jp.
authors.forename: Jun
authors.initials: J
authors.lastname: Sakurai
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Matsui
authors.forename: Takao
authors.initials: T
authors.lastname: Hiraki
authors.forename: Toshihiro
authors.initials: T
authors.lastname: Iguchi
authors.forename: Hiroyasu
authors.initials: H
authors.lastname: Fujiwara
authors.forename: Hideo
authors.initials: H
authors.lastname: Gobara
authors.forename: Toshiharu
authors.initials: T
authors.lastname: Mitsuhashi
authors.forename: Takeshi
authors.initials: T
authors.lastname: Nagasaka
authors.forename: Susumu
authors.initials: S
authors.lastname: Kanazawa
mesh_terms: D055011:Ablation Techniques; D017115:Catheter Ablation / Q000379:methods*; D002985:Clinical Protocols; D017322:Clinical Trials, Phase II as Topic; D015179:Colorectal Neoplasms / Q000473:pathology*; D006801:Humans; D008175:Lung Neoplasms / Q000556:secondary* / Q000628:therapy; D014057:Tomography, X-Ray Computed