title: The toll-like receptor 3 pathway in homeostasis, responses to injury and wound repair.
abstract: In addition to their established roles in host defence, Toll-like Receptors (TLRs) have emerging roles in control of homeostasis, injury and wound repair. The dsRNA-sensing receptor, TLR3, has been particularly implicated in such processes in several different tissues including the skin, intestine and liver, as well as in the control of reparative mechanisms in the brain, heart and kidneys, following ischemia reperfusion injury. In this review, we provide an overview of TLR3 signalling and functions in inflammation, tissue damage and repair processes, as well as therapeutic opportunities that may arise in the future from knowledge of such pathways.
authors.affiliation: Institute for Molecular Bioscience (IMB), The University of Queensland, Brisbane, Qld 4072, Australia; IMB Centre for Inflammation and Disease Research, The University of Queensland, Brisbane, Qld 4072, Australia; Australian Infectious Disease Research Centre, The University of Queensland, Brisbane, Qld 4072, Australia.
authors.forename: Divya
authors.initials: D
authors.lastname: Ramnath
authors.affiliation: Centre for Liver Disease Research, School of Medicine, The University of Queensland, Translational Research Institute, Brisbane, Qld 4102, Australia; Department of Gastroenterology and Hepatology, Princess Alexandra Hospital, Brisbane, Qld 4102, Australia.
authors.forename: Elizabeth E
authors.initials: EE
authors.lastname: Powell
authors.affiliation: Melbourne Dental School and Oral Health Cooperative Research Centre, The University of Melbourne, Parkville 3010, Australia; Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Parkville 3010, Australia.
authors.forename: Glen M
authors.initials: GM
authors.lastname: Scholz
authors.affiliation: Institute for Molecular Bioscience (IMB), The University of Queensland, Brisbane, Qld 4072, Australia; IMB Centre for Inflammation and Disease Research, The University of Queensland, Brisbane, Qld 4072, Australia; Australian Infectious Disease Research Centre, The University of Queensland, Brisbane, Qld 4072, Australia. Electronic address: m.sweet@imb.uq.edu.au.
authors.forename: Matthew J
authors.initials: MJ
authors.lastname: Sweet
mesh_terms: D000818:Animals; D006706:Homeostasis; D006801:Humans; D008954:Models, Biological; D009928:Organ Specificity; D015398:Signal Transduction; D051196:Toll-Like Receptor 3 / Q000378:metabolism*; D014945:Wound Healing
chemical_list: D051196:Toll-Like Receptor 3
keywords: Homeostasis; Ischemia reperfusion injury; Poly(IC); Toll-like receptor 3; UV-damage; Wound repair