title: Natural Polyphenols for Prevention and Treatment of Cancer.
abstract: There is much epidemiological evidence that a diet rich in fruits and vegetables could lower the risk of certain cancers. The effect has been attributed, in part, to natural polyphenols. Besides, numerous studies have demonstrated that natural polyphenols could be used for the prevention and treatment of cancer. Potential mechanisms included antioxidant, anti-inflammation as well as the modulation of multiple molecular events involved in carcinogenesis. The current review summarized the anticancer efficacy of major polyphenol classes (flavonoids, phenolic acids, lignans and stilbenes) and discussed the potential mechanisms of action, which were based on epidemiological, in vitro, in vivo and clinical studies within the past five years.
authors.affiliation: Guangdong Provincial Key Laboratory of Food, Nutrition and Health, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China. zhouyue3@mail2.sysu.edu.cn.
authors.forename: Yue
authors.initials: Y
authors.lastname: Zhou
authors.affiliation: Guangdong Provincial Key Laboratory of Food, Nutrition and Health, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China. zhengj37@mail2.sysu.edu.cn.
authors.forename: Jie
authors.initials: J
authors.lastname: Zheng
authors.affiliation: Guangdong Provincial Key Laboratory of Food, Nutrition and Health, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China. liya28@mail2.sysu.edu.cn.
authors.forename: Ya
authors.initials: Y
authors.lastname: Li
authors.affiliation: Guangdong Provincial Key Laboratory of Food, Nutrition and Health, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China. xudp@mail2.sysu.edu.cn.
authors.forename: Dong-Ping
authors.initials: DP
authors.lastname: Xu
authors.affiliation: School of Chinese Medicine, The University of Hong Kong, Hong Kong, China. u3003781@connect.hku.hk.
authors.forename: Sha
authors.initials: S
authors.lastname: Li
authors.affiliation: Guangdong Provincial Key Laboratory of Food, Nutrition and Health, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China. chenyum@mail.sysu.edu.cn.
authors.forename: Yu-Ming
authors.initials: YM
authors.lastname: Chen
authors.affiliation: Guangdong Provincial Key Laboratory of Food, Nutrition and Health, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China. lihuabin@mail.sysu.edu.cn.|South China Sea Bioresource Exploitation and Utilization Collaborative Innovation Center, Sun Yat-sen University, Guangzhou 510006, China. lihuabin@mail.sysu.edu.cn.
authors.forename: Hua-Bin
authors.initials: HB
authors.lastname: Li
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000627:therapeutic use*; D005502:Food; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy* / Q000517:prevention & control*; D010944:Plants / Q000737:chemistry; D059808:Polyphenols / Q000627:therapeutic use*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D059808:Polyphenols
keywords: anti-inflammation; anticancer; antioxidant; flavonoid; polyphenol