title: Asparaginase-associated pancreatitis is not predicted by hypertriglyceridemia or pancreatic enzyme levels in children with acute lymphoblastic leukemia.
abstract: l-Asparaginase is an important drug for treatment of childhood acute lymphoblastic leukemia (ALL), but is associated with serious toxicities, including pancreatitis and hypertriglyceridemia (HTG). Asparaginase-associated pancreatitis (AAP) is a common reason for stopping asparaginase treatment. The aim of this study was to explore if HTG or early elevations in pancreatic enzymes were associated with the subsequent development of AAP.
  
  
  
  Children (1.0-17.9 years) diagnosed with ALL, treated with asparaginase for 30 weeks, according to the NOPHO ALL2008 protocol at the University Hospital Rigshospitalet, Copenhagen, Denmark, were eligible. Pancreatic enzymes, triglycerides, and cholesterol were measured regularly.
  
  
  
  Thirty-one patients were included. Seven patients were diagnosed with AAP. HTG was most evident when PEG-asparaginase and dexamethasone were administered concomitantly. Overall, there was no significant difference in triglyceride levels in patients who experienced AAP and patients who did not. An increase in triglyceride levels during concomitant dexamethasone therapy in delayed intensification was significantly associated with an increase in pancreas-specific amylase levels two weeks later (P = 0.005).
  
  
  
  AAP does not seem to be associated with HTG. Continuous monitoring of pancreas enzymes does not predict AAP.
authors.affiliation: Department of Pediatrics and Adolescent Medicine, University Hospital Rigshospitalet, Copenhagen, Denmark.
authors.forename: Raheel Altaf
authors.initials: RA
authors.lastname: Raja
authors.affiliation: Department of Pediatrics and Adolescent Medicine, University Hospital Rigshospitalet, Copenhagen, Denmark.|Institute of Clinical Medicine, Faculty of Medicine, University of Copenhagen, Copenhagen, Denmark.
authors.forename: Kjeld
authors.initials: K
authors.lastname: Schmiegelow
authors.affiliation: Section of Biostatistics, Department of Public Health, University of Copenhagen, Denmark.
authors.forename: Ditte Nørbo
authors.initials: DN
authors.lastname: Sørensen
authors.affiliation: Department of Pediatrics and Adolescent Medicine, University Hospital Rigshospitalet, Copenhagen, Denmark.
authors.forename: Thomas Leth
authors.initials: TL
authors.lastname: Frandsen
mesh_terms: D000293:Adolescent; D001215:Asparaginase / Q000009:adverse effects*; D014408:Biomarkers, Tumor / Q000378:metabolism*; D002648:Child; D002675:Child, Preschool; D003718:Denmark / Q000453:epidemiology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015228:Hypertriglyceridemia / Q000175:diagnosis / Q000453:epidemiology*; D007223:Infant; D008297:Male; D009367:Neoplasm Staging; D055292:Pancreatic alpha-Amylases / Q000097:blood*; D010195:Pancreatitis / Q000097:blood / Q000139:chemically induced* / Q000175:diagnosis; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy* / Q000201:enzymology / Q000473:pathology; D011379:Prognosis; D014280:Triglycerides / Q000378:metabolism*
chemical_list: D014408:Biomarkers, Tumor; D014280:Triglycerides; D055292:Pancreatic alpha-Amylases; D001215:Asparaginase
keywords: children; hypertriglyceridemia; l-asparaginase; leukemia; pancreatitis