title: [Clinical Characteristics,Treatment Strategies and Prognostic Factors of 254 Cases of Non Hodgkin's Lymphoma].
abstract: OBJECTIVE
  To analyze the clinical characteristics and prognostic factors of patients with non-Hodgkin's lymphoma (NHL) in single center of the Northwest area in China for 10 years, so as to provide the evidences for early diagnosis, stratified treatmetn, evaluation of therapeutic efficacy and prognosis, as well as early prevation and so on.
  
  
  METHODS
  The clinical data of 254 patients with NHL were analyzed retrospectively, the clinical characteristics were evaluated by unvariate analysis; then the single factors affecting prognosis were enrolled in multivariate analysis and the independent prognostic factors affecting the survival of patients were summarized.
  
  
  RESULTS
  A total of 182 cases achieved CR（71.6%）, PR 30 cases（11.8%）, SD 22 cases（8.7%）, PD 20 cases（7.9%）, and RR 212 cases（83.5%). The statistically significant unfavorable prognostic factors for NHL revealed by univariate analysis included age, invasive, Ann Arbor stage, relapse, and total course of chemotherapy. Cox regression model analysis showed that the Ann Arbor stage, IPI, ECOG, B symptoms, peripheral blood cell levels, short-term efficacy, course to achieve CR, and total course of chemotherapy all were the independent prognostic factors.
  
  
  CONCLUSIONS
  The incidence characteristics of NHL in this center displayed mainly middle and high-risk B cell type with attacks at young age, aggression and in lymph nodes. For aggressive lymphoma, the single and multiple prognostic factors may provide the significant guides for the treatment, individualized plan and evaluation of prognosis. The course number of chemotherapy is one of the important factors for survival and prognosis, possessed clinical significance, and worth further clinical research for aggressive lymphoma.
authors.affiliation: Department of Hematology, The Second Hospital Affiliated to Xi'an Jiaotong University, Xian 710004, Shaanxi Province, China.E-mail：maxr0910@163.com.
authors.forename: Xiao-Rong
authors.initials: XR
authors.lastname: Ma
authors.affiliation: Department of Hematology, The Second Hospital Affiliated to Xi'an Jiaotong University, Xian 710004, Shaanxi Province, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Xu
authors.affiliation: Department of Hematology, The Second Hospital Affiliated to Xi'an Jiaotong University, Xian 710004, Shaanxi Province, China.
authors.forename: Jin
authors.initials: J
authors.lastname: Wang
authors.affiliation: Department of Hematology, The Second Hospital Affiliated to Xi'an Jiaotong University, Xian 710004, Shaanxi Province, China.
authors.forename: Wang-Gang
authors.initials: WG
authors.lastname: Zhang
authors.affiliation: Department of Hematology, The Second Hospital Affiliated to Xi'an Jiaotong University, Xian 710004, Shaanxi Province, China.
authors.forename: Yin-Xia
authors.initials: YX
authors.lastname: Chen
authors.affiliation: Department of Hematology, The Second Hospital Affiliated to Xi'an Jiaotong University, Xian 710004, Shaanxi Province, China.
authors.forename: Xing-Mei
authors.initials: XM
authors.lastname: Cao
authors.affiliation: Department of Hematology, The Second Hospital Affiliated to Xi'an Jiaotong University, Xian 710004, Shaanxi Province, China.
authors.forename: Ai-Li
authors.initials: AL
authors.lastname: He
authors.affiliation: Department of Hematology, The Second Hospital Affiliated to Xi'an Jiaotong University, Xian 710004, Shaanxi Province, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Liu
authors.affiliation: Department of Hematology, The Second Hospital Affiliated to Xi'an Jiaotong University, Xian 710004, Shaanxi Province, China.
authors.forename: Jian-Li
authors.initials: JL
authors.lastname: Wang
authors.affiliation: Department of Hematology, The Second Hospital Affiliated to Xi'an Jiaotong University, Xian 710004, Shaanxi Province, China.
authors.forename: Wan-Hong
authors.initials: WH
authors.lastname: Zhao
authors.affiliation: Department of Hematology, The Second Hospital Affiliated to Xi'an Jiaotong University, Xian 710004, Shaanxi Province, China.
authors.forename: Yun
authors.initials: Y
authors.lastname: Yang
mesh_terms: D001402:B-Lymphocytes; D002681:China; D006801:Humans; D008198:Lymph Nodes; D008228:Lymphoma, Non-Hodgkin; D015999:Multivariate Analysis; D011379:Prognosis; D012008:Recurrence; D012189:Retrospective Studies