title: Microglia: Senescence Impairs Clearance of Myelin Debris.
abstract: Growing evidence highlights the crucial physiological functions of microglia that rely on their phagocytic activities, which can be compromised with age. A new study reports the impaired clearance of myelin debris by microglia in the brain, leading to insoluble lysosomal inclusions and contributing to the immune dysfunction and senescence of these cells.
authors.affiliation: Neuroscience Laboratory, CHU de Québec Research Center and Department of Molecular Medicine, Faculty of Medicine, Laval University, 2705 Laurier boul., Québec City, QC G1V 4G2, Canada.
authors.forename: Peter
authors.initials: P
authors.lastname: Thériault
authors.affiliation: Neuroscience Laboratory, CHU de Québec Research Center and Department of Molecular Medicine, Faculty of Medicine, Laval University, 2705 Laurier boul., Québec City, QC G1V 4G2, Canada. Electronic address: Serge.Rivest@crchudequebec.ulaval.ca.
authors.forename: Serge
authors.initials: S
authors.lastname: Rivest
mesh_terms: D001921:Brain; D006801:Humans; D017628:Microglia; D009186:Myelin Sheath; D010586:Phagocytes; D010587:Phagocytosis