title: The role of titanium-prepared platelet-rich fibrin in palatal mucosal wound healing and histoconduction.
abstract: OBJECTIVE
  We aimed to determine the clinical effects of titanium-prepared, platelet-rich fibrin (T-PRF) on human palatal mucosal wound healing (PMWH) and to identify its effect on time-dependent changes in palatal soft-tissue thickness (PSTT) in terms of histoconduction, which is a new concept.
  
  
  METHODS
  Free gingival graft (FGG) donor sites were treated with T-PRF and compared with an untreated control group. The results of colour match and H2O2-bubbling tests for complete wound epithelization (CWE) were recorded on days 3, 7, 14 and 21. Pain level, number of analgesics used and bleeding status were recorded for the first 7 days. PSTT was measured at baseline and after 1 and 6 months.
  
  
  RESULTS
  Colour match scores of the test group were significantly higher than those of the control group at 7 and 14 days. CWE was observed at a higher frequency in the test group than in the control group on day 14. Post-operative bleeding prevalence was lower in the test group than in the control group for the first 2 days. A time-dependent decrease in PSTT was observed at 1 and 6 months in the control group compared with baseline (baseline, 4.23 ± 0.62 mm; 1 month, 4.01 ± 0.68 mm; and 6 months, 3.93 ± 0.69 mm). However, no significant difference was found in the test group (baseline, 4.29 ± 0.64 mm; 1 month, 4.61 ± 0.51 mm; and 6 months, 4.51 ± 0.58 mm).
  
  
  CONCLUSIONS
  The T-PRF membrane exhibited positive effects on PMWH. T-PRF, which is a promising autogenous matrix for histoconduction, may also be preferred as an autogenous alternative to connective tissue grafts in the treatment of gingival recessions and peri-implant mucosal recessions.
authors.affiliation: a Department of Periodontology , Karadeniz Technical University , Trabzon , Turkey.
authors.forename: Gülbahar
authors.initials: G
authors.lastname: Ustaoğlu
authors.affiliation: a Department of Periodontology , Karadeniz Technical University , Trabzon , Turkey.
authors.forename: Esra
authors.initials: E
authors.lastname: Ercan
authors.affiliation: b Department of Periodontology , Haydarpasa Training Hospital, Gulhane Military Medical Academy , İstanbul , Turkey.
authors.forename: Mustafa
authors.initials: M
authors.lastname: Tunali
mesh_terms: D000700:Analgesics / Q000627:therapeutic use; D001672:Biocompatible Materials / Q000737:chemistry*; D001792:Blood Platelets / Q000502:physiology*; D003116:Color; D003238:Connective Tissue / Q000187:drug effects / Q000473:pathology / Q000637:transplantation; D005337:Fibrin / Q000627:therapeutic use*; D005500:Follow-Up Studies; D005881:Gingiva / Q000187:drug effects / Q000473:pathology / Q000637:transplantation*; D005889:Gingival Recession / Q000601:surgery; D006801:Humans; D006861:Hydrogen Peroxide / Q000008:administration & dosage; D006472:Oral Hemorrhage / Q000145:classification; D016877:Oxidants / Q000008:administration & dosage; D010147:Pain Measurement / Q000379:methods; D010149:Postoperative Pain / Q000517:prevention & control; D010159:Palate / Q000601:surgery; D019106:Postoperative Hemorrhage / Q000145:classification; D011446:Prospective Studies; D062326:Re-Epithelialization / Q000187:drug effects; D014025:Titanium / Q000737:chemistry*; D060053:Transplant Donor Site / Q000473:pathology*; D014945:Wound Healing / Q000187:drug effects
chemical_list: D000700:Analgesics; D001672:Biocompatible Materials; D016877:Oxidants; D005337:Fibrin; D006861:Hydrogen Peroxide; D014025:Titanium
keywords: Gingiva; histoconduction; platelet-rich fibrin; tissue transplantation; wound epithelization