title: Langerhans cell sarcoma: a case report and review of the literature.
abstract: We present the case of a 62-year-old male patient with a three-month history of pain in the left shoulder. Magnetic resonance imaging of the left scapula showed an osteo-destructive lesion. H and E stained sections revealed a Langerhans cell sarcoma, and immunohistochemistry was performed additionally; CD68, CD163, CD14, fascin, HLA-DR, lysozyme, S100 CD1a and langerin showed a positive reaction, while CD20, CD30, CD34, CD31, pan-cytokeratin, AE/1AE3, SMA, desmin, EMA, ERG, INI-1, CD21, CD4, PLAP, MPO and CD117c were negative. We suggested palliative treatment with chemotherapy and radiation. The patient refused any treatment and died 2 weeks later.
authors.affiliation: David T. Liu, Department of Orthopedic Surgery, Medical University of Graz, Auenbruggerplatz 5, 8036 Graz, Austria, e-mail: david.liu@stud.medunigraz.at.
authors.forename: D T
authors.initials: DT
authors.lastname: Liu
authors.forename: J
authors.initials: J
authors.lastname: Friesenbichler
authors.forename: L A
authors.initials: LA
authors.lastname: Holzer
authors.forename: B
authors.initials: B
authors.lastname: Liegl-Atzwanger
authors.forename: C
authors.initials: C
authors.lastname: Beham-Schmid
authors.forename: A
authors.initials: A
authors.lastname: Leithner
mesh_terms: D014408:Biomarkers, Tumor / Q000032:analysis; D006801:Humans; D007150:Immunohistochemistry; D054752:Langerhans Cell Sarcoma / Q000473:pathology*; D008297:Male; D008875:Middle Aged
chemical_list: D014408:Biomarkers, Tumor