title: Poor Cervical Cancer Screening Attendance and False Negatives. A Call for Organized Screening.
abstract: OBJECTIVE
  The objective of this study was to describe prior negative screening history and symptoms around the time of diagnosis of incident cervical cancer (CC) cases diagnosed between 2000 and 2010 within the Asturias public health system.
  
  
  METHODS
  Records from 374 women diagnosed with CC between 2000 and 2010 from all public hospitals in Asturias were retrieved. Clinical information, FIGO stage and all previous cytological data were extracted from clinical and histopathological records. Proportional differences were assessed using chi-square tests. Logistic regression analysis was used to estimate odds ratios (OR) and 95% confidence intervals (CI). Inter-observer agreement in cytology was checked by comparing concordance values using k-statistics.
  
  
  RESULTS
  No prior screening history was recorded in 60.7% of CC cases and its absence increased with age and advanced stage. Advanced stage (e.g., ≥ II) at diagnosis was associated with age (>50 years) and adenocarcinoma (ADC) compared to younger women and those with a squamous cell carcinoma (SCC). False negative smears were identified in 27.1% of women with CC (ADC 52.6% vs. SCC 16.2%, p<0.05).
  
  
  CONCLUSIONS
  Absence of prior screening history was common among CC cases. Organized actions to reduce "under screening" and the use of highly sensitive HPV-based tests could be useful strategies in reducing the burden of CC in Asturias.
authors.affiliation: Obstetrics and Gynecology Department, Jarrio Hospital, SESPA, Coaña, Asturias, Spain.
authors.forename: Marta
authors.initials: M
authors.lastname: Castillo
authors.affiliation: Pathology Department, Asturias Central University Hospital, Oviedo University, SESPA, Oviedo, Asturias, Spain.
authors.forename: Aurora
authors.initials: A
authors.lastname: Astudillo
authors.affiliation: Infections and Cancer Unit, Cancer Epidemiology Research Programme, Institut Català d'Oncologia-IDIBELL, L´Hospitalet de Llobregat, Barcelona, Spain.
authors.forename: Omar
authors.initials: O
authors.lastname: Clavero
authors.affiliation: Pathology Department, Medical Center of Asturias, Oviedo, Asturias, Spain.
authors.forename: Julio
authors.initials: J
authors.lastname: Velasco
authors.affiliation: Infections and Cancer Unit, Cancer Epidemiology Research Programme, Institut Català d'Oncologia-IDIBELL, L´Hospitalet de Llobregat, Barcelona, Spain.
authors.forename: Raquel
authors.initials: R
authors.lastname: Ibáñez
authors.affiliation: Infections and Cancer Unit, Cancer Epidemiology Research Programme, Institut Català d'Oncologia-IDIBELL, L´Hospitalet de Llobregat, Barcelona, Spain.|CIBER Epidemiology and Public Health (CIBERESP), Barcelona, Spain.
authors.forename: Silvia
authors.initials: S
authors.lastname: de Sanjosé
mesh_terms: D000230:Adenocarcinoma / Q000175:diagnosis* / Q000473:pathology; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000175:diagnosis* / Q000473:pathology; D057210:Delayed Diagnosis; D003951:Diagnostic Errors / Q000706:statistics & numerical data*; D055088:Early Detection of Cancer / Q000523:psychology / Q000706:statistics & numerical data*; D005188:False Negative Reactions; D005260:Female; D006801:Humans; D033162:Incidental Findings; D008875:Middle Aged; D015588:Observer Variation; D016017:Odds Ratio; D062486:Public Health Surveillance; D012044:Regression Analysis; D012189:Retrospective Studies; D013030:Spain; D002583:Uterine Cervical Neoplasms / Q000175:diagnosis* / Q000473:pathology