title: Chronic pancreatitis: Do serum biomarkers provide an association with an inflammageing phenotype?
abstract: BACKGROUND
  Chronic pancreatitis is an inflammatory disorder of the pancreas that is associated with accelerated mortality for patients suffering from this disease. The association between chronic inflammation and accelerated biological ageing has been well described and is often referred to as "inflammageing". In this review we seek to determine how systemic inflammation in chronic pancreatitis may contribute to an accelerated ageing phenotype.
  
  
  METHODS
  A systematic literature search with a predefined search protocol was performed on Medline, Embase and Cochrane libraries according to the PRISMA guidelines.
  
  
  RESULTS
  The initial search identified 499 studies. After title, abstract and full text screen of the search results, 20 were included for further evaluation. In the 20 remaining articles 41 inflammatory mediators were identified - mainly involved in chronic inflammation, fibrosis and particularly cardinal features of inflammageing such as sarcopenia and osteoporosis.
  
  
  CONCLUSIONS
  Chronic pancreatitis is associated with elevated levels of inflammatory mediators many of which are associated with an accelerated ageing phenotype and may explain some of the clinical sequelae of this disease.
authors.affiliation: II. Medizinische Klinik und Poliklinik, Klinikum rechts der Isar, Technische Universität München, Ismaninger Straße 22, 81675, München, Germany. Electronic address: sebastian.rasch@mri.tum.de.
authors.forename: Sebastian
authors.initials: S
authors.lastname: Rasch
authors.affiliation: Department of Gastroenterology LUHSH Kauno klinikos, Kaunas, Lithuania.
authors.forename: Irena
authors.initials: I
authors.lastname: Valantiene
authors.affiliation: Centre of Hepatology, Gastroenterology and Dietetics, Vilnius University Hospital SANTARIŠKIŲ KLINIKOS, Vilnius, Lithuania.
authors.forename: Artautas
authors.initials: A
authors.lastname: Mickevicius
authors.affiliation: Department for Internal Medicine, Neurology and Dermatology, Division of Gastroenterology, University of Leipzig, Leipzig, Germany.
authors.forename: Sebastian
authors.initials: S
authors.lastname: Beer
authors.affiliation: Department of Gastroenterology and Hepatology, University of Halle, Halle, Germany.
authors.forename: Jonas
authors.initials: J
authors.lastname: Rosendahl
authors.affiliation: HPB Unit, Department of Surgery, Freeman Hospital, Newcastle upon Tyne, UK.
authors.forename: Richard M
authors.initials: RM
authors.lastname: Charnley
authors.affiliation: HPB Unit, Department of Surgery, Freeman Hospital, Newcastle upon Tyne, UK.
authors.forename: Stuart M
authors.initials: SM
authors.lastname: Robinson
mesh_terms: D015415:Biomarkers / Q000097:blood*; D006801:Humans; D007249:Inflammation / Q000097:blood* / Q000000981:diagnostic imaging* / Q000209:etiology; D050500:Pancreatitis, Chronic / Q000097:blood* / Q000000981:diagnostic imaging*; D010641:Phenotype
chemical_list: D015415:Biomarkers
keywords: Ageing; Chronic pancreatitis; Cytokine; Inflammation; Systematic review