title: Procalcitonin: A new biomarker for the cardiologist.
abstract: Due to its high accuracy for the diagnosis of bacterial infections, the inflammatory biomarker procalcitonin (PCT) is increasingly being used in patients with suspected infection. In patients with infections of the respiratory tract, it allows rapid rule out of bacterial etiology and facilitates decisions pertaining to antibiotic management. A growing body of evidence also supports PCT testing in patients with cardiovascular disorders including, but not limited to, those with shortness of breath, possible heart failure, suspected endocarditis, and acute coronary syndromes. In these clinical situations, PCT may provide diagnostic information on the likelihood of an infectious cause in cardiovascular patients presenting with acute symptoms such as dyspnea. It may also have a prognostic value that correlates with clinical outcome and can potentially guide drug therapy. This narrative review summarizes current concepts and evidence from the published literature on the strengths and limitations of PCT as a biomarker, with a focus on patients with a variety of cardiovascular disorders.
authors.affiliation: Medical University Department, Division of General Internal and Emergency Medicine, Kantonsspital Aarau, Aarau, Switzerland. Electronic address: Schuetzph@gmail.com.
authors.forename: Philipp
authors.initials: P
authors.lastname: Schuetz
authors.affiliation: UCSD Division of Cardiology, Sulpizio Cardiovascular Center, Mail Code 7411, 9444 Medical Center Drive, La Jolla, CA 92037-7411, USA. Electronic address: lbdaniels@ucsd.edu.
authors.forename: Lori B
authors.initials: LB
authors.lastname: Daniels
authors.affiliation: Asclepius Medical Communications LLC, 38 E Ridgewood Ave #254, Ridgewood, NJ 07450-3808, USA. Electronic address: prasad.kulkarni@asclepius.co.
authors.forename: Prasad
authors.initials: P
authors.lastname: Kulkarni
authors.affiliation: Innovative Clinical Trials, Department of Cardiology & Pneumology, University Medical Center Göttingen (UMG), Göttingen, Germany. Electronic address: s.anker@cachexia.de.
authors.forename: Stefan D
authors.initials: SD
authors.lastname: Anker
authors.affiliation: Medical University Department, Division of General Internal and Emergency Medicine, Kantonsspital Aarau, Aarau, Switzerland. Electronic address: happy.mueller@unibas.ch.
authors.forename: Beat
authors.initials: B
authors.lastname: Mueller
mesh_terms: D000208:Acute Disease; D015415:Biomarkers / Q000097:blood; D002116:Calcitonin / Q000097:blood*; D000072096:Cardiologists; D002318:Cardiovascular Diseases / Q000097:blood / Q000175:diagnosis*; D006801:Humans
chemical_list: D015415:Biomarkers; D002116:Calcitonin
keywords: Biomarker; Dyspnea; Procalcitonin