title: Omadacycline: development of a novel aminomethylcycline antibiotic for treating drug-resistant bacterial infections.
abstract: Omadacycline is a first-in-class aminomethylcycline antibiotic that circumvents common tetracycline resistance mechanisms. In vitro omadacycline has potent activity against Gram-positive aerobic bacteria including methicillin-resistant Staphylococcus aureus, penicillin-resistant and multidrug-resistant Streptococcus pneumoniae, and vancomycin-resistant Enterococcus spp. It is also active against common Gram-negative aerobes, some anaerobes and atypical bacteria including Legionella spp. and Chlamydia spp. Ongoing Phase III clinical trials with omadacycline are investigating once daily doses of 100 mg intravenously followed by once-daily doses of 300 mg orally for the treatment of acute bacterial skin and skin structure infections and community-acquired bacterial pneumonia. This paper provides an overview of the microbiology, nonclinical evaluations, clinical pharmacology and initial clinical experience with omadacycline.
authors.affiliation: Paratek Pharmaceuticals, 1000 First Avenue, Suite 400, King of Prussia, PA 19406, USA.
authors.forename: Stephen
authors.initials: S
authors.lastname: Villano
authors.affiliation: Paratek Pharmaceuticals, 1000 First Avenue, Suite 400, King of Prussia, PA 19406, USA.
authors.forename: Judith
authors.initials: J
authors.lastname: Steenbergen
authors.affiliation: Paratek Pharmaceuticals, 1000 First Avenue, Suite 400, King of Prussia, PA 19406, USA.
authors.forename: Evan
authors.initials: E
authors.lastname: Loh
mesh_terms: D001419:Bacteria / Q000187:drug effects; D001424:Bacterial Infections / Q000188:drug therapy*; D002689:Chlamydia / Q000187:drug effects; D017714:Community-Acquired Infections / Q000188:drug therapy; D004334:Drug Administration Schedule; D024901:Drug Resistance, Multiple, Bacterial / Q000187:drug effects*; D006088:Gram-Negative Aerobic Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D007875:Legionella / Q000187:drug effects; D055624:Methicillin-Resistant Staphylococcus aureus / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D012867:Skin / Q000382:microbiology; D017192:Skin Diseases, Bacterial / Q000188:drug therapy; D013296:Streptococcus pneumoniae / Q000187:drug effects; D013754:Tetracyclines / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics* / Q000627:therapeutic use*; D065507:Vancomycin-Resistant Enterococci / Q000187:drug effects
chemical_list: D013754:Tetracyclines; C000591640:omadacycline
keywords: aminomethylcycline; bacterial infection; omadacycline; tetracyclines