title: A case of acanthosis nigricans as a paraneoplastic syndrome with squamous cell lung cancer.
abstract: A 55-year-old man presented with oral mucosal ulcers, blackening of both hands, and hyperpigmentation on axillary, anal, and inguinal regions for the last 3 months, which were all progressive. The patient was referred to the oncology department with the diagnosis of acanthosis nigricans for investigation of an underlying malignancy. He was a smoker. A computed tomography scan of thorax revealed enlarged mediastinal lymphadenopathies and a lesion on the left upper lobe. Fine-needle aspiration biopsy of the mediastinal lesion was consistent with squamous cell carcinoma, and biopsies of the skin and oral mucosal lesion also further confirmed the diagnosis of acanthosis nigricans. After docetaxel and cisplatin chemotherapy, a significant improvement in his skin and mucosal lesions was observed with almost complete resolution of the pulmonary lesion and the mediastinal lymph nodes.
authors.affiliation: Medical Oncology Department, Hacettepe University Cancer Institute.
authors.forename: Yusuf
authors.initials: Y
authors.lastname: Karakas
authors.affiliation: Medical Oncology Department, Hacettepe University Cancer Institute.
authors.forename: Ece
authors.initials: E
authors.lastname: Esin
authors.affiliation: Medical Oncology Department, Hacettepe University Cancer Institute.
authors.forename: Sahin
authors.initials: S
authors.lastname: Lacin
authors.affiliation: Department of Medical Pathology, Ankara University School of Medicine, Ankara, Turkey.
authors.forename: Koray
authors.initials: K
authors.lastname: Ceyhan
authors.affiliation: Department of Medical Pathology, Ankara University School of Medicine, Ankara, Turkey.
authors.forename: Aylin Okcu
authors.initials: AO
authors.lastname: Heper
authors.affiliation: Medical Oncology Department, Hacettepe University Cancer Institute.
authors.forename: Suayib
authors.initials: S
authors.lastname: Yalcin
keywords: acanthosis nigricans; paraneoplastic syndrome; squamous cell lung cancer