title: An enzyme-free and resettable platform for the construction of advanced molecular logic devices based on magnetic beads and DNA.
abstract: A series of multiple logic circuits based on magnetic beads and DNA are constructed to perform resettable nonarithmetic functions, including a digital comparator, 4-to-2 encoder and 2-to-3 decoder, 2-to-1 encoder and 1-to-2 decoder. The signal reporter is composed of a G-quadruplex/NMM complex and a AuNP-surface immobilized molecular beacon. It is the first time that the designed DNA-based nonarithmetic nanodevices can share the same DNA platform with a reset function, which has great potential application in information processing at the molecular level. Another novel feature of the designed system is that the developed nanodevices are operated on a simple DNA/magnetic bead platform and share a constant threshold setpoint without the assistance of any negative logic conversion. The reset function is realized by heating the output system and the magnetic separation of the computing modules. Due to the biocompatibility and design flexibility of DNA, these investigations may provide a new route towards the development of resettable advanced logic circuits in biological and biomedical fields.
authors.affiliation: Department of Chemistry, Taizhou University, Jiaojiang, 318000, China. hdm@tzc.edu.cn.
authors.forename: Siqi
authors.initials: S
authors.lastname: Zhang
authors.affiliation: College of Sciences, Northeastern University, Shenyang, 110819, China. sun1th@163.com.
authors.forename: Kun
authors.initials: K
authors.lastname: Wang
authors.affiliation: Department of Food Engineering, Shandong Business Institute, Yantai, 264670, China.
authors.forename: Congcong
authors.initials: C
authors.lastname: Huang
authors.affiliation: College of Sciences, Northeastern University, Shenyang, 110819, China. sun1th@163.com.
authors.forename: Zhenyu
authors.initials: Z
authors.lastname: Li
authors.affiliation: College of Sciences, Northeastern University, Shenyang, 110819, China. sun1th@163.com.
authors.forename: Ting
authors.initials: T
authors.lastname: Sun
authors.affiliation: Department of Chemistry, Taizhou University, Jiaojiang, 318000, China. hdm@tzc.edu.cn.
authors.forename: De-Man
authors.initials: DM
authors.lastname: Han
mesh_terms: D039301:Computers, Molecular; D004247:DNA / Q000737:chemistry*; D054856:G-Quadruplexes; D006046:Gold; D008128:Logic; D008280:Magnetics; D053768:Metal Nanoparticles
chemical_list: D006046:Gold; D004247:DNA