title: [Association between single nucleotide polymorphism of adenylyl cyclase 3 and essential hypertension].
abstract: OBJECTIVE
  To explore the association between the tag single nucleotide polymorphism (tag SNP) of the adenylyl cyclase 3 (ADCY3) and the essential hypertension (EH).
  
  
  METHODS
  From April to July 2013, a total of 1 061 subjects diagnosed with EH and 1 218 control subjects were recruited from Ningbo, Zhejiang Province. Information was collected by face-to-face interview. Twelve tag SNPs were detected by ligase detection reaction technique.
  
  
  RESULTS
  After adjusted for age, gender, body mass index and other related factors, logistic regression analysis showed that 3 loci (rs11689546, rs7593130, rs2241759)were associated with EH. AG genotype of rs11689546 was associated with 0.494 times lower risk of EH (OR=0.494, 95%CI 0.246-0.993; compared with AA genotype). CT genotype of rs7593130 was associated with 1.596 times higher risk of EH (OR=1.596, 95%CI 1.009-2.524; compared with TT genotype), and CT/CC genotype of rs7593130 was associated with 1.627 times higher risk of EH (OR=1.627, 95%CI 1.034-2.559; compared with TT genotype). AG genotype of rs2241759 was associated with 0.669 times lower risk of EH (OR=0.669, 95%CI 0.503-0.891; compared with AA genotype), and CT/CC genotype of rs2241759 was associated with 0.687 times lower risk of EH (OR=0.687, 95%CI 0.518-0.911; compared with TT genotype).
  
  
  CONCLUSIONS
  The polymorphisms of ADCY3 are associated with lower (G allele of the rs11689546 locus and G allele of the rs2241759 locus) or higher (C allele of the rs7593130 locus) risk of essential hypertension.
authors.affiliation: Department of Preventive Medicine, School of Medicine, Hangzhou Normal University, Hangzhou 310018, China.
authors.forename: Y
authors.initials: Y
authors.lastname: Chen
authors.forename: Y W
authors.initials: YW
authors.lastname: Gong
authors.forename: X Q
authors.initials: XQ
authors.lastname: Zhou
authors.forename: H X
authors.initials: HX
authors.lastname: Xu
authors.forename: L
authors.initials: L
authors.lastname: Yang
authors.forename: Y Y
authors.initials: YY
authors.lastname: Wu
mesh_terms: D000262:Adenylyl Cyclases / Q000235:genetics*; D000483:Alleles; D016022:Case-Control Studies; D000075222:Essential Hypertension; D005838:Genotype; D006801:Humans; D006973:Hypertension / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide
chemical_list: D000262:Adenylyl Cyclases; C421784:adenylate cyclase 3