title: [The prospects of the biotherapy for refractory uveitis].
abstract: Noninfectious uveitis is a kind of recurrent autoimmune disease and a major cause of blindness in clinical practice. Corticosteroids are the conventional medication, but have severe side effects for long-term users, and some refractory patients are treated with immunosuppressive agents. Because the pathogenesis of uveitis is related to the autoimmune imbalance mediated by CD4 + T lymphocytes. The macrophages, lymphocytes and some cytokines are involved. The immunomodulatory therapy is targeted to block the lymphocytes, cytokines or their receptors, so as to control the inflammatory damage or minimize the recurrence of the disease. The biological agents include the anti-tumor necrosis factor agents, interferon-α, interleukin receptor antagonists, cytotoxic T lymphocyte associated antigen fusion proteins and CD20 chimeric antibody. They bring a hope for the treatment of the patients with refractory uveitis. Because of the limited number of randomized clinical trials and patients, the indications, long-term effects, safety and side effects of these biologics need to be observed. In this article, the experiments and clinical trials of these new biologics for the treatment of uveitis in recent years are reviewed. (Chin J Ophthalmol, 2016, 52: 551-556).
authors.affiliation: Tianjin Eye Hospital, Tianjin Key Lab. of Ophthalmology and Visual Science, Tianjin Eye Institute, Clinical College of Ophthalmology of Tianjin Medical University, Tianjin 300020, China.
authors.forename: Y Z
authors.initials: YZ
authors.lastname: Zheng
mesh_terms: D000911:Antibodies, Monoclonal / Q000627:therapeutic use; D001688:Biological Products / Q000276:immunology / Q000627:therapeutic use; D001691:Biological Therapy; D015496:CD4-Positive T-Lymphocytes; D016207:Cytokines; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D058990:Molecular Targeted Therapy / Q000379:methods*; D016032:Randomized Controlled Trials as Topic; D016896:Treatment Outcome; D014605:Uveitis / Q000188:drug therapy* / Q000276:immunology
chemical_list: D000911:Antibodies, Monoclonal; D001688:Biological Products; D016207:Cytokines; D007166:Immunosuppressive Agents