title: Brain (18)F-FDG, (18)F-Florbetaben PET/CT, (123)I-FP-CIT SPECT and Cardiac (123)I-MIBG Imaging for Diagnosis of a "Cerebral Type" of Lewy Body Disease.
abstract: A 67-year-old man was referred for fluctuating neuropsychiatric symptoms, featuring depression, delirious episodes, recurrent visual hallucinations and catatonic syndrome associated with cognitive decline. No parkinsonism was found clinically even under neuroleptic treatment. (18)F-FDG PET/CT showed hypometabolism in the posterior associative cortex including the occipital cortex, suggesting Lewy body dementia, but (123)I-FP-CIT SPECT was normal and cardiac (123)I-MIBG imaging showed no signs of sympathetic denervation. Alzheimer's disease was excluded by a normal (18)F-florbetaben PET/CT. This report suggests a rare case of α-synucleinopathy without brainstem involvement, referred to as "cerebral type" of Lewy body disease.
authors.affiliation: Department of Nuclear Medicine, AP-HP, Henri-Mondor Teaching Hospital, 51 Ave. du Mal de Lattre de Tassigny, F-94010 Créteil, France.
authors.forename: Axel
authors.initials: A
authors.lastname: Van Der Gucht
authors.affiliation: Cognitive Neurology Unit, H. Mondor Hospital, Assistance Publique-Hôpitaux de Paris/Paris-Est University, 51 Ave. du Mal de Lattre de Tassigny, F-94010 Créteil, France.
authors.forename: Laurent
authors.initials: L
authors.lastname: Cleret de Langavant
authors.affiliation: Department of Nuclear Medicine, AP-HP, Henri-Mondor Teaching Hospital, 51 Ave. du Mal de Lattre de Tassigny, F-94010 Créteil, France.
authors.forename: Ophélie
authors.initials: O
authors.lastname: Bélissant
authors.affiliation: Department of Nuclear Medicine, AP-HP, Henri-Mondor Teaching Hospital, 51 Ave. du Mal de Lattre de Tassigny, F-94010 Créteil, France.
authors.forename: Corentin
authors.initials: C
authors.lastname: Rabu
authors.affiliation: Department of Nuclear Medicine, AP-HP, Henri-Mondor Teaching Hospital, 51 Ave. du Mal de Lattre de Tassigny, F-94010 Créteil, France.
authors.forename: Anne-Ségolène
authors.initials: AS
authors.lastname: Cottereau
authors.affiliation: Department of Nuclear Medicine, AP-HP, Henri-Mondor Teaching Hospital, 51 Ave. du Mal de Lattre de Tassigny, F-94010 Créteil, France.
authors.forename: Eva
authors.initials: E
authors.lastname: Evangelista
authors.affiliation: Department of Nuclear Medicine, AP-HP, Henri-Mondor Teaching Hospital, 51 Ave. du Mal de Lattre de Tassigny, F-94010 Créteil, France.
authors.forename: Julia
authors.initials: J
authors.lastname: Chalaye
authors.affiliation: Department of Nuclear Medicine, AP-HP, Henri-Mondor Teaching Hospital, 51 Ave. du Mal de Lattre de Tassigny, F-94010 Créteil, France.
authors.forename: Sophie
authors.initials: S
authors.lastname: Bonnot-Lours
authors.affiliation: Department of Nuclear Medicine, AP-HP, Henri-Mondor Teaching Hospital, 51 Ave. du Mal de Lattre de Tassigny, F-94010 Créteil, France.
authors.forename: Gilles
authors.initials: G
authors.lastname: Fénelon
authors.affiliation: Department of Nuclear Medicine, AP-HP, Henri-Mondor Teaching Hospital, 51 Ave. du Mal de Lattre de Tassigny, F-94010 Créteil, France.
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Itti
keywords: (MeSH terms); 123I-FP-CIT; 18F-FDG; 18F-florbetaben; Brain imaging; Lewy body disease; MIBG