title: Peculiarities of data interpretation upon direct tissue analysis by Fourier transform ion cyclotron resonance mass spectrometry.
abstract: The importance of high-resolution mass spectrometry for the correct data interpretation of a direct tissue analysis is demonstrated with an example of its clinical application for an endometriosis study. Multivariate analysis of the data discovers lipid species differentially expressed in different tissues under investigation. High-resolution mass spectrometry allows unambiguous separation of peaks with close masses that correspond to proton and sodium adducts of phosphatidylcholines and to phosphatidylcholines differing in double bond number.
authors.affiliation: Department of System Biology in Reproduction, Federal State Budget Institution "Research Center for Obstetrics, Gynecology and Perinatology", 4 Oparin Street, Moscow 117997, Russian Federation.
authors.forename: Vtaliy
authors.initials: V
authors.lastname: Chagovets
authors.affiliation: Department of System Biology in Reproduction, Federal State Budget Institution "Research Center for Obstetrics, Gynecology and Perinatology", 4 Oparin Street, Moscow 117997, Russian Federation. >Moscow Institute of Physics and Technology, 141700 Dolgoprudnyi, Moscow Region, Russian Federation.
authors.forename: Aleksey
authors.initials: A
authors.lastname: Kononikhin
authors.affiliation: Department of System Biology in Reproduction, Federal State Budget Institution "Research Center for Obstetrics, Gynecology and Perinatology", 4 Oparin Street, Moscow 117997, Russian Federation. >Moscow Institute of Physics and Technology, 141700 Dolgoprudnyi, Moscow Region, Russian Federation.
authors.forename: Nataliia
authors.initials: N
authors.lastname: Starodubtseva
authors.affiliation: Moscow Institute of Physics and Technology, 141700 Dolgoprudnyi, Moscow Region, Russian Federation. Institute for Energy Problems of Chemical Physics, Russian Academy of Sciences, Leninskii pr., 38, bld. 2 Moscow, 119334, Russian Federation. Skolkovo Institute of Science and Technology, 100 Novaya Street, Skolkovo 143025 Russian Federation.
authors.forename: Yury
authors.initials: Y
authors.lastname: Kostyukevich
authors.affiliation: Moscow Institute of Physics and Technology, 141700 Dolgoprudnyi, Moscow Region, Russian Federation. nstitute for Energy Problems of Chemical Physics, Russian Academy of Sciences, Leninskii pr., 38, bld. 2 Moscow, 119334, Russian Federation.
authors.forename: Igor
authors.initials: I
authors.lastname: Popov
authors.affiliation: Department of System Biology in Reproduction, Federal State Budget Institution "Research Center for Obstetrics, Gynecology and Perinatology", 4 Oparin street, Moscow 117997, Russian Federation. vfrankevich@gmail.com.
authors.forename: Vladimir
authors.initials: V
authors.lastname: Frankevich
authors.affiliation: Moscow Institute of Physics and Technology, 141700 Dolgoprudnyi, Moscow Region, Russian Federation. Institute for Energy Problems of Chemical Physics, Russian Academy of Sciences, Leninskii pr., 38, bld. 2 Moscow, 119334, Russian Federation. Skolkovo Institute of Science and Technology, 100 Novaya Street, Skolkovo 143025 Russian Federation.
authors.forename: Eugene
authors.initials: E
authors.lastname: Nikolaev
mesh_terms: D000465:Algorithms; D015415:Biomarkers / Q000032:analysis; D003198:Computer Simulation; D017357:Cyclotrons; D003627:Data Interpretation, Statistical; D005260:Female; D006801:Humans; D008055:Lipids / Q000032:analysis* / Q000737:chemistry; D015233:Models, Statistical; D015999:Multivariate Analysis; D010048:Ovarian Cysts / Q000737:chemistry* / Q000175:diagnosis*; D011522:Protons; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D012964:Sodium / Q000737:chemistry; D021241:Spectrometry, Mass, Electrospray Ionization / Q000379:methods*; D046888:Tissue Array Analysis / Q000379:methods
chemical_list: D015415:Biomarkers; D008055:Lipids; D011522:Protons; D012964:Sodium