title: Variation in Visual Outcome to Anti-Vascular Endothelial Growth Factors in Choroidal Neovascular Membrane Developing in Eyes with Previously Untreated Versus Focal Laser-Treated Central Serous Chorioretinopathy.
abstract: OBJECTIVE
  To report the visual outcome in choroidal neovascular membrane developing (CNVM) in eyes with central serous chorioretinopathy (CSCR) with our without prior focal laser.
  
  
  METHODS
  A retrospective case series of eyes with CNVM secondary to CSCR treated with intravitreal anti-VEGF.
  
  
  RESULTS
  Ten eyes of nine patients of CNVM with CSCR who underwent intravitreal anti-VEGF injections were analyzed. Five eyes had CNVM without prior laser photocoagulation, and five eyes developed CNVM after laser photocoagulation for CSCR. Intravitreal injection bevacizumab was given in five eyes and ranibizumab in five eyes. The lasered group had significantly shorter duration of the disease, fewer injections given, and better visual acuity at final follow-up (P <0.05). None had any recurrences of either CSCR or CNVM until the last follow-up.
  
  
  CONCLUSIONS
  CNVM in CSCR with prior history of focal laser had better outcome than that developed de novo, without prior history of laser.
authors.affiliation: a Department of Vitreoretina , Sankara Nethralaya , Kolkata , West Bengal , India.
authors.forename: Rupak
authors.initials: R
authors.lastname: Roy
authors.affiliation: a Department of Vitreoretina , Sankara Nethralaya , Kolkata , West Bengal , India.
authors.forename: Kumar
authors.identifier: http://orcid.org/0000-0001-8263-3837
authors.initials: K
authors.lastname: Saurabh
authors.affiliation: a Department of Vitreoretina , Sankara Nethralaya , Kolkata , West Bengal , India.
authors.forename: Debmalya
authors.initials: D
authors.lastname: Das
authors.affiliation: a Department of Vitreoretina , Sankara Nethralaya , Kolkata , West Bengal , India.
authors.forename: Pradeep Kumar
authors.initials: PK
authors.lastname: Panigrahi
authors.affiliation: a Department of Vitreoretina , Sankara Nethralaya , Kolkata , West Bengal , India.
authors.forename: Sudipta
authors.initials: S
authors.lastname: Das
authors.affiliation: a Department of Vitreoretina , Sankara Nethralaya , Kolkata , West Bengal , India.
authors.forename: Swakshyar Saumya
authors.initials: SS
authors.lastname: Pal
authors.affiliation: b Shri Bhagwan Mahavir Vitreoretina Services , Sankara Nethralaya , Chennai , Tamil Nadu , India.
authors.forename: Amit
authors.initials: A
authors.lastname: Jain
mesh_terms: D000293:Adolescent; D000328:Adult; D020533:Angiogenesis Inhibitors / Q000627:therapeutic use*; D000068258:Bevacizumab / Q000627:therapeutic use*; D056833:Central Serous Chorioretinopathy / Q000150:complications* / Q000188:drug therapy / Q000601:surgery; D020256:Choroidal Neovascularization / Q000188:drug therapy* / Q000503:physiopathology; D005260:Female; D005451:Fluorescein Angiography; D006801:Humans; D058449:Intravitreal Injections; D017075:Laser Coagulation; D008297:Male; D008875:Middle Aged; D000069579:Ranibizumab / Q000627:therapeutic use*; D012189:Retrospective Studies; D041623:Tomography, Optical Coherence; D014792:Visual Acuity / Q000502:physiology*; D055815:Young Adult
chemical_list: D020533:Angiogenesis Inhibitors; D000068258:Bevacizumab; D000069579:Ranibizumab
keywords: Anti-vascular endothelial growth factor; central serous chorioretinopathy; choroidal neovascular membrane; focal laser photocoagulation; visual outcome