title: Involvement of the NADPH Oxidase NOX2-Derived Brain Oxidative Stress in an Unusual Fatal Case of Cocaine-Related Neurotoxicity Associated With Excited Delirium Syndrome.
abstract: Here, we investigated the possible role of the Nicotinamide Adenine Dinucleotide Phosphate oxidase NOX2-derived brain oxidative stress in a fatal case of cocaine-related neurotoxicity, associated to excited delirium syndrome. We detected a strong NOX2 immunoreactivity, mainly in cortical GABAergic neurons and astrocytes, with a minor presence in microglia, glutamatergic and dopaminergic neurons as well as a significant immunostaining for other markers of oxidative stress (8OhDG, HSP70, HSP90, and NF-κB) and apoptotic phenomena. These results support a crucial role of NOX2-derived brain oxidative stress in cocaine-induced brain dysfunctions and neurotoxicity.
authors.affiliation: From the Department of Clinical and Experimental Medicine, University of Foggia, Foggia, Italy.
authors.forename: Stefania
authors.initials: S
authors.lastname: Schiavone
authors.forename: Irene
authors.initials: I
authors.lastname: Riezzo
authors.forename: Emanuela
authors.initials: E
authors.lastname: Turillazzi
authors.forename: Luigia
authors.initials: L
authors.lastname: Trabace
mesh_terms: D000328:Adult; D003042:Cocaine / Q000633:toxicity*; D003693:Delirium / Q000139:chemically induced / Q000201:enzymology*; D017809:Fatal Outcome; D006801:Humans; D008297:Male; D008562:Membrane Glycoproteins; D000074662:NADPH Oxidase 2; D019255:NADPH Oxidases; D020258:Neurotoxicity Syndromes / Q000201:enzymology*; D018384:Oxidative Stress
chemical_list: D008562:Membrane Glycoproteins; C056558:CYBB protein, human; D000074662:NADPH Oxidase 2; D019255:NADPH Oxidases; D003042:Cocaine