title: Endovascular Electrodes for Electrical Stimulation of Blood Vessels for Vasoconstriction - a Finite Element Simulation Study.
abstract: Hemorrhagic shock accounts for 30-40 percent of trauma mortality, as bleeding may sometimes be hard to control. Application of short electrical pulses on blood vessels was recently shown to elicit robust vasoconstriction and reduction of blood loss following vascular injury. In this study we present a novel approach for vasoconstriction based on endovascular application of electrical pulses for situations where access to the vessel is limited. In addition to ease of access, we hypothesize that this novel approach will result in a localized and efficient vasoconstriction. Using computer modeling (COMSOL Multiphysics, Electric Currents Module), we studied the effect of endovascular pulsed electrical treatment on abdominal aorta of pigs, and compared the efficiency of different electrodes configurations on the electric field amplitude, homogeneity and locality when applied on a blood vessel wall. Results reveal that the optimal configuration is the endovascular approach where four electrodes are used, spaced 13 mm apart. Furthermore, computer based temperature investigations (bio-heat model, COMSOL Multiphysics) show that the maximum expected temperature rise is of 1.2 degrees; highlighting the safety of the four endovascular electrodes configuration. These results can aid in planning the application of endovascular pulsed electrical treatment as an efficient and safe vasoconstriction approach.
authors.affiliation: Mina and Everard Goodman Faculty of Life Sciences, Optometry and Visual Science Track and Bar-Ilan's Institute for Nanotechnology and Advanced Materials (BINA), Bar-Ilan University, Ramat-Gan, Israel.
authors.forename: Noa
authors.initials: N
authors.lastname: Kezurer
authors.affiliation: Mina and Everard Goodman Faculty of Life Sciences, Optometry and Visual Science Track and Bar-Ilan's Institute for Nanotechnology and Advanced Materials (BINA), Bar-Ilan University, Ramat-Gan, Israel.
authors.forename: Nairouz
authors.initials: N
authors.lastname: Farah
authors.affiliation: Mina and Everard Goodman Faculty of Life Sciences, Optometry and Visual Science Track and Bar-Ilan's Institute for Nanotechnology and Advanced Materials (BINA), Bar-Ilan University, Ramat-Gan, Israel.
authors.forename: Yossi
authors.initials: Y
authors.lastname: Mandel
mesh_terms: D000818:Animals; D001012:Aorta, Abdominal / Q000503:physiopathology*; D003198:Computer Simulation; D004599:Electric Stimulation Therapy; D004566:Electrodes; D020342:Finite Element Analysis; D008955:Models, Cardiovascular; D013552:Swine; D014661:Vasoconstriction