title: Faecal Calprotectin in Treated and Untreated Children With Coeliac Disease and Juvenile Idiopathic Arthritis.
abstract: The present study aimed to provide evidence on whether children at risk of gastrointestinal inflammation have increased measurements of faecal calprotectin (FC). FC was measured in 232 children; 55 children (n = 11 treatment naïve) with juvenile idiopathic arthritis (JIA), 63 with coeliac disease (CD); 17 with new diagnosis before and after treatment on gluten-free diet and 114 controls. None of the treatment-naive children with JIA had raised FC. Four JIA patients on treatment had a raised FC but in all cases a repeat test was normal. In newly diagnosed patients with CD, the median (interquartile range) FC was higher 36.4 (26-61) than that in controls 25.0 (23-41) mg/kg (P = 0.045) but this significantly decreased 25 (25-25) mg/kg (P = 0.012) after 6 months on gluten-free diet. Random measurements of FC are not raised in children with JIA or CD. A significant elevation of FC in these groups is not explained by their diagnosis and therefore needs further investigation.
authors.affiliation: *Human Nutrition, School of Medicine, College of Medical, Veterinary and Life Sciences †Child Health, School of Medicine, College of Medical, Veterinary and Life Sciences, Queen Elisabeth University Hospital, University of Glasgow ‡Department of Paediatric Gastroenterology, Royal Hospital for Children, Glasgow, United Kingdom.
authors.forename: Olga
authors.initials: O
authors.lastname: Biskou
authors.forename: Janet
authors.initials: J
authors.lastname: Gardner-Medwin
authors.forename: Mary
authors.initials: M
authors.lastname: Mackinder
authors.forename: Martin
authors.initials: M
authors.lastname: Bertz
authors.forename: Clare
authors.initials: C
authors.lastname: Clark
authors.forename: Vaios
authors.initials: V
authors.lastname: Svolos
authors.forename: Richard K
authors.initials: RK
authors.lastname: Russell
authors.forename: Christine A
authors.initials: CA
authors.lastname: Edwards
authors.forename: Paraic
authors.initials: P
authors.lastname: McGrogan
authors.forename: Konstantinos
authors.initials: K
authors.lastname: Gerasimidis
mesh_terms: D001171:Arthritis, Juvenile / Q000150:complications*; D002446:Celiac Disease / Q000150:complications / Q000175:diagnosis*; D002648:Child; D002675:Child, Preschool; D005243:Feces / Q000737:chemistry; D005260:Female; D006801:Humans; D039841:Leukocyte L1 Antigen Complex / Q000378:metabolism*; D008297:Male
chemical_list: D039841:Leukocyte L1 Antigen Complex