title: 808 nm photocontrolled UCL imaging guided chemo/photothermal synergistic therapy with single UCNPs-CuS@PAA nanocomposite.
abstract: Recently, incorporating multiple components into one nanostructured matrix to construct a multifunctional nanomedical platform has attracted more and more attention for simultaneous anticancer diagnosis and therapy. Herein, a novel anti-cancer nanoplatform has been successfully developed by coating a uniform shell of poly(acrylic acid) (PAA) on the surface of CuS-decorated upconversion nanoparticles (UCNPs). Benefiting from the enhanced 808 nm-excited UCL intensity of the multilayer UCNPs, the unique photothermal properties of CuS and the pH-responsive drug release capacity of the PAA shell, such a nanoplatform design of UCNPs-CuS@PAA (labeled UCP) offers a new route to achieve 808 nm-excited UCL imaging guided chemo/photothermal combination therapy. We have found that the combined chemo/photothermal therapy can significantly improve the therapeutic efficacy compared with chemotherapy or photothermal therapy (PTT) alone. Moreover, the pH/NIR-dependent drug delivery properties, 808 nm-excited UCL imaging, as well as in vitro/in vivo biocompatibility tests were also investigated in detail. These results show promising applications of UCP nanoparticles as a novel theranostic agent for the detection and treatment of tumors.
authors.affiliation: State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, P. R. China. jlin@ciac.ac.cn cxli@ciac.ac.cn and University of Chinese Academy of Sciences, Beijing, 100049, China.
authors.forename: Bei
authors.initials: B
authors.lastname: Liu
authors.affiliation: State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, P. R. China. jlin@ciac.ac.cn cxli@ciac.ac.cn.
authors.forename: Chunxia
authors.initials: C
authors.lastname: Li
authors.affiliation: State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, P. R. China. jlin@ciac.ac.cn cxli@ciac.ac.cn and University of Chinese Academy of Sciences, Beijing, 100049, China.
authors.forename: Zhongxi
authors.initials: Z
authors.lastname: Xie
authors.affiliation: State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, P. R. China. jlin@ciac.ac.cn cxli@ciac.ac.cn.
authors.forename: Zhiyao
authors.initials: Z
authors.lastname: Hou
authors.affiliation: State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, P. R. China. jlin@ciac.ac.cn cxli@ciac.ac.cn.
authors.forename: Ziyong
authors.initials: Z
authors.lastname: Cheng
authors.affiliation: Institute for Biomedical Materials and Devices, Faculty of Science, University of Technology Sydney, NSW 2007, Australia.
authors.forename: Dayong
authors.initials: D
authors.lastname: Jin
authors.affiliation: State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, P. R. China. jlin@ciac.ac.cn cxli@ciac.ac.cn.
authors.forename: Jun
authors.initials: J
authors.lastname: Lin
mesh_terms: D000180:Acrylic Resins / Q000008:administration & dosage* / Q000737:chemistry; D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000737:chemistry; D045744:Cell Line, Tumor; D003300:Copper / Q000008:administration & dosage* / Q000737:chemistry; D004317:Doxorubicin / Q000008:administration & dosage / Q000737:chemistry; D006801:Humans; D008027:Light; D051379:Mice; D008856:Microscopy, Fluorescence; D053758:Nanoparticles / Q000008:administration & dosage* / Q000737:chemistry; D009369:Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000473:pathology; D010789:Phototherapy; D047368:Tumor Burden / Q000187:drug effects
chemical_list: D000180:Acrylic Resins; D000970:Antineoplastic Agents; C006903:carbopol 940; D003300:Copper; D004317:Doxorubicin; C017846:cupric sulfide