title: Measurement of interleukin-6 (IL-6) and erythropoietin (EPO) in umbilical cords of preterm infants with intraventricular hemorrhage in two hospitals in Tehran.
abstract: BACKGROUND
  Intraventricular hemorrhage (IVH) is an important cause of death in premature infants. This study aimed to assess the association of the umbilical cord plasma levels of interleukin-6 (IL-6) and erythropoietin (EPO) with the occurrence and severity of IVH in premature infants.
  
  
  METHODS
  Fifty premature newborns of mothers with chorioamnionitis risk factor were selected via nonprobability sampling. The concentration of the cord plasma's IL-6 and erythropoietin were measured by enzyme-linked immunosorbent assay (ELISA) for 3 days. Finally, all samples underwent sonography for the diagnosis of IVH. Results analyzed statistically.
  
  
  RESULTS
  Among the samples, 68.98% of them were diagnosed with IVH grade 1. The most severe IVH cases were detected on the second day. The mean and standard deviation of IL-6 level was 74.71 ± 50.53 in the case group and 24.10 ± 46.10 in the control group. There was a correlation between IL-6 levels and IVH (p = 0.0005). The mean and standard deviation of EPO level was 18.38 ± 15.23 in the IVH group and 6.45 ± 13.48 in samples without IVH. A correlation was detected between EPO level and IVH (p = 0.005).
  
  
  CONCLUSIONS
  The concentration of IL-6 and EPO levels of the cord plasma was higher in the premature newborns with IVH.
authors.affiliation: a Research Center of Pediatric Infectious Diseases, Iran University of Medical Sciences , Tehran , Iran.
authors.forename: Nastaran
authors.initials: N
authors.lastname: Khosravi
authors.affiliation: b Medical Microbiology, Pasteur Institute of Iran (IPI) , Tehran , Iran , and.|c Research Center of Pediatric Infectious Diseases, Tehran University of Medical Sciences , Tehran , Iran.
authors.forename: Ali
authors.initials: A
authors.lastname: Badamchi
authors.affiliation: a Research Center of Pediatric Infectious Diseases, Iran University of Medical Sciences , Tehran , Iran.
authors.forename: Nasrin
authors.initials: N
authors.lastname: Khalesi
authors.affiliation: a Research Center of Pediatric Infectious Diseases, Iran University of Medical Sciences , Tehran , Iran.
authors.forename: Azardokht
authors.initials: A
authors.lastname: Tabatabaee
authors.affiliation: a Research Center of Pediatric Infectious Diseases, Iran University of Medical Sciences , Tehran , Iran.
authors.forename: Mehri
authors.initials: M
authors.lastname: Naghdalipour
authors.affiliation: a Research Center of Pediatric Infectious Diseases, Iran University of Medical Sciences , Tehran , Iran.
authors.forename: Ramin
authors.initials: R
authors.lastname: Asgarian
mesh_terms: D015415:Biomarkers / Q000097:blood; D000074042:Cerebral Intraventricular Hemorrhage / Q000097:blood* / Q000175:diagnosis / Q000453:epidemiology; D002821:Chorioamnionitis / Q000453:epidemiology; D003430:Cross-Sectional Studies; D004797:Enzyme-Linked Immunosorbent Assay; D004921:Erythropoietin / Q000097:blood*; D005260:Female; D005312:Fetal Blood / Q000737:chemistry*; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D007235:Infant, Premature, Diseases / Q000097:blood*; D015850:Interleukin-6 / Q000097:blood*; D007492:Iran; D008297:Male; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000453:epidemiology; D014463:Ultrasonography; D014470:Umbilical Cord
chemical_list: D015415:Biomarkers; C554270:EPO protein, human; C508600:IL6 protein, human; D015850:Interleukin-6; D004921:Erythropoietin
keywords: Interleukin-6; erythropoietin; intraventricular hemorrhage; premature infant; umbilical cord plasma