title: Pollution by metals: Is there a relationship in glycemic control?
abstract: There are evidences of environmental pollution and health effects. Metals are pollutants implicated in systemic toxicity. One of the least studied effects, but which is currently becoming more important, is the effect of metals on glycemic control. Metals have been implicated as causes of chronic inflammation and oxidative stress and are associated to obesity, hyperglycemia and even diabetes. Arsenic, iron, mercury, lead, cadmium and nickel have been studied as a risk factor for hyperglycemia and diabetes. There is another group of metals that causes hypoglycemia such as vanadium, chromium, zinc and magnesium by different mechanisms. Zinc, magnesium and chromium deficiency is associated with increased risk of diabetes. This review summarizes some metals involved in glycemic control and pretends to alert health professionals about considering environmental metals as an important factor that could explain the poor glycemic control in patients. Further studies are needed to understand this poorly assessed problem.
authors.affiliation: Departamento de Biología Celular y Tisular, Facultad de Medicina, Universidad Nacional Autonoma de Mexico (UNAM), Mexico City, Mexico. Electronic address: hemadgovi@yahoo.com.mx.
authors.forename: Adriana
authors.initials: A
authors.lastname: González-Villalva
authors.affiliation: Laboratorio de Neuromorfología, FES Iztacala, UNAM CP 54090 Edo. de México, Mexico. Electronic address: barenque@unam.mx.
authors.forename: Laura
authors.initials: L
authors.lastname: Colín-Barenque
authors.affiliation: Departamento de Biología Celular y Tisular, Facultad de Medicina, Universidad Nacional Autonoma de Mexico (UNAM), Mexico City, Mexico. Electronic address: pbizarro@unam.mx.
authors.forename: Patricia
authors.initials: P
authors.lastname: Bizarro-Nevares
authors.affiliation: Departamento de Biología Celular y Tisular, Facultad de Medicina, Universidad Nacional Autonoma de Mexico (UNAM), Mexico City, Mexico. Electronic address: marsrojlem@hotmail.com.
authors.forename: Marcela
authors.initials: M
authors.lastname: Rojas-Lemus
authors.affiliation: Departamento de Biología Celular y Tisular, Facultad de Medicina, Universidad Nacional Autonoma de Mexico (UNAM), Mexico City, Mexico. Electronic address: vianeyrodriguezlara@yahoo.com.mx.
authors.forename: Vianey
authors.initials: V
authors.lastname: Rodríguez-Lara
authors.affiliation: Departamento de Biología Celular y Tisular, Facultad de Medicina, Universidad Nacional Autonoma de Mexico (UNAM), Mexico City, Mexico. Electronic address: igarciapelaez@yahoo.com.
authors.forename: Isabel
authors.initials: I
authors.lastname: García-Pelaez
authors.affiliation: Departamento de Biología Celular y Tisular, Facultad de Medicina, Universidad Nacional Autonoma de Mexico (UNAM), Mexico City, Mexico. Electronic address: ustarroz@unam.mx.
authors.forename: Martha
authors.initials: M
authors.lastname: Ustarroz-Cano
authors.affiliation: Departamento de Biología Celular y Tisular, Facultad de Medicina, Universidad Nacional Autonoma de Mexico (UNAM), Mexico City, Mexico. Electronic address: nelly_ciencias@hotmail.com.
authors.forename: Nelly
authors.initials: N
authors.lastname: López-Valdez
authors.affiliation: Departamento de Biología Celular y Tisular, Facultad de Medicina, Universidad Nacional Autonoma de Mexico (UNAM), Mexico City, Mexico. Electronic address: albarranjc@ciencias.unam.mx.
authors.forename: Juan Carlos
authors.initials: JC
authors.lastname: Albarrán-Alonso
authors.affiliation: Departamento de Biología Celular y Tisular, Facultad de Medicina, Universidad Nacional Autonoma de Mexico (UNAM), Mexico City, Mexico. Electronic address: fortoul@unam.mx.
authors.forename: Teresa I
authors.initials: TI
authors.lastname: Fortoul
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D004785:Environmental Pollutants / Q000633:toxicity*; D006801:Humans; D006943:Hyperglycemia / Q000139:chemically induced* / Q000378:metabolism; D007003:Hypoglycemia / Q000139:chemically induced* / Q000378:metabolism; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D008670:Metals / Q000633:toxicity*
chemical_list: D001786:Blood Glucose; D004785:Environmental Pollutants; D007328:Insulin; D008670:Metals
keywords: Diabetes; Hyperglycemia; Hypoglycemia; Insulin; Metals; Pollution