title: Selenium Alleviates Oxidative Stress and Lung Damage Induced by Aluminum Chloride in Adult Rats: Biochemical and Histological Approach.
abstract: Our study pertains to the potential ability of selenium, used as a nutritional supplement, to alleviate oxidative stress induced by aluminum chloride in the lung tissue. Rats have received during 21 days either aluminum chloride (AlCl3) (400 ppm) via drinking water, AlCl3associated with Na2SeO3(0.5 mg/kg of diet), or only Na2SeO3. Exposure of rats to AlCl3induced lung oxidative stress with an increase of malondialdehyde, hydrogen peroxide, and protein carbonyls levels. An alteration of lactate dehydrogenase activities and antioxidant redox status, enzymatic (catalase, superoxide dismutase, and glutathione peroxidase), and non-enzymatic (non-protein thiols, glutathione, metallothionein, and vitamin C) was also observed. These biochemical modifications were substantiated by histopathological data showing alveolar edema, a large number of hemosiderin-laden macrophages, and emphysema. Se supplementation attenuated the levels of oxidative stress by restoring antioxidant state and improved lung histological damage. Our results revealed that Se, a trace element with antioxidant properties, was effective in preventing lung damage.
authors.affiliation: Animal Physiology Laboratory, Sciences Faculty of Sfax, University of Sfax, BP 1171, 3000, Sfax, Tunisia. ghorbel21@gmail.com.
authors.forename: Imen
authors.initials: I
authors.lastname: Ghorbel
authors.affiliation: Animal Physiology Laboratory, Sciences Faculty of Sfax, University of Sfax, BP 1171, 3000, Sfax, Tunisia.
authors.forename: Awatef
authors.initials: A
authors.lastname: Elwej
authors.affiliation: Animal Physiology Laboratory, Sciences Faculty of Sfax, University of Sfax, BP 1171, 3000, Sfax, Tunisia.
authors.forename: Mariem
authors.initials: M
authors.lastname: Chaabane
authors.affiliation: Biochemistry Laboratory, CHU Hedi Chaker, University of Sfax, 3029, Sfax, Tunisia.
authors.forename: Kamel
authors.initials: K
authors.lastname: Jamoussi
authors.affiliation: Anatomopathology Laboratory, CHU Habib Bourguiba, University of Sfax, 3029, Sfax, Tunisia.
authors.forename: Hela
authors.initials: H
authors.lastname: Mnif
authors.affiliation: Anatomopathology Laboratory, CHU Habib Bourguiba, University of Sfax, 3029, Sfax, Tunisia.
authors.forename: Tahia
authors.initials: T
authors.lastname: Boudawara
authors.affiliation: Animal Physiology Laboratory, Sciences Faculty of Sfax, University of Sfax, BP 1171, 3000, Sfax, Tunisia.
authors.forename: Najiba
authors.initials: N
authors.lastname: Zeghal
mesh_terms: D000077410:Aluminum Chloride; D017607:Aluminum Compounds / Q000633:toxicity*; D000818:Animals; D000975:Antioxidants / Q000378:metabolism / Q000494:pharmacology; D001205:Ascorbic Acid / Q000378:metabolism; D001835:Body Weight / Q000187:drug effects; D002374:Catalase / Q000378:metabolism; D002712:Chlorides / Q000633:toxicity*; D004326:Drinking / Q000187:drug effects; D004435:Eating / Q000187:drug effects; D005260:Female; D005978:Glutathione / Q000378:metabolism; D005979:Glutathione Peroxidase / Q000378:metabolism; D006861:Hydrogen Peroxide / Q000378:metabolism; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D008168:Lung / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D008315:Malondialdehyde / Q000378:metabolism; D008668:Metallothionein / Q000378:metabolism; D009929:Organ Size / Q000187:drug effects; D010084:Oxidation-Reduction / Q000187:drug effects; D018384:Oxidative Stress / Q000187:drug effects*; D050050:Protein Carbonylation / Q000187:drug effects; D017208:Rats, Wistar; D012643:Selenium / Q000494:pharmacology*; D013482:Superoxide Dismutase / Q000378:metabolism
chemical_list: D017607:Aluminum Compounds; D000975:Antioxidants; D002712:Chlorides; D000077410:Aluminum Chloride; D008315:Malondialdehyde; D008668:Metallothionein; D006861:Hydrogen Peroxide; D007770:L-Lactate Dehydrogenase; D002374:Catalase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D005978:Glutathione; D012643:Selenium; D001205:Ascorbic Acid
keywords: Aluminum; Lung; Oxidative stress; Rats; Selenium