title: [Role of endoplasmic reticulum-plasma membrane junctions in intracellular calcium homeostasis and cardiovascular disease].
abstract: Calcium overload is one of the important mechanisms of cardiovascular disease. Endoplasmic reticulum is an important organelle which regulates intracellular calcium homeostasis by uptake, storage and mobilization of calcium. So it plays a critical role in regulation of intracellular calcium homeostasis. Endoplasmic reticulum, which is widely distributed in cytoplasm, has a large number of membrane junction sites. Recent studies have reported that these junction sites are distributed on plasma membrane and organelle membranes (mitochondria, lysosomes, Golgi apparatus, etc.), separately. They could form complexes to regulate calcium transport. In this review, we briefly outlined the recent research progresses of endoplasmic reticulum-plasma membrane junctions in intracellular calcium homeostasis and cardiovascular disease, which may offer a new strategy for prevention and treatment of cardiovascular disease.
authors.affiliation: Department of Pharmacology, Xi'an Jiaotong University Health Science Center, Xi'an 710061, China.
authors.forename: Ming
authors.initials: M
authors.lastname: Zhao
authors.affiliation: Department of Pharmacology, Xi'an Jiaotong University Health Science Center, Xi'an 710061, China.
authors.forename: Hang-Huan
authors.initials: HH
authors.lastname: Jia
authors.affiliation: Department of Pharmacology, Xi'an Jiaotong University Health Science Center, Xi'an 710061, China.
authors.forename: Man
authors.initials: M
authors.lastname: Xu
authors.affiliation: Department of Pharmacology, Xi'an Jiaotong University Health Science Center, Xi'an 710061, China.
authors.forename: Xiao-Jiang
authors.initials: XJ
authors.lastname: Yu
authors.affiliation: Department of Pharmacology, Xi'an Jiaotong University Health Science Center, Xi'an 710061, China.
authors.forename: Long-Zhu
authors.initials: LZ
authors.lastname: Liu
authors.affiliation: Department of Pharmacology, Xi'an Jiaotong University Health Science Center, Xi'an 710061, China. zwj@mail.xjtu.edu.cn.
authors.forename: Wei-Jin
authors.initials: WJ
authors.lastname: Zang
mesh_terms: D002118:Calcium; D002318:Cardiovascular Diseases; D002462:Cell Membrane; D004721:Endoplasmic Reticulum; D006706:Homeostasis; D006801:Humans
chemical_list: D002118:Calcium