title: Direct and Repeated Clinical Measurements of pO2 for Enhancing Cancer Therapy and Other Applications.
abstract: The first systematic multi-center study of the clinical use of EPR oximetry has begun, with funding as a PPG from the NCI. Using particulate oxygen sensitive EPR, materials in three complementary forms (India Ink, "OxyChips", and implantable resonators) the clinical value of the technique will be evaluated. The aims include using repeated measurement of tumor pO2 to monitor the effects of treatments on tumor pO2, to use the measurements to select suitable subjects for the type of treatment including the use of hyperoxic techniques, and to provide data that will enable existing clinical techniques which provide data relevant to tumor pO2 but which cannot directly measure it to be enhanced by determining circumstances where they can give dependable information about tumor pO2.
authors.affiliation: Department of Radiology, Geisel School of Medicine at Dartmouth, One Medical Center Drive Lebanon, Lebanon, NH, USA. Harold.Swartz@Dartmouth.edu.|Department of Medicine, Geisel School of Medicine at Dartmouth, One Medical Center Drive Lebanon, Lebanon, NH, USA. Harold.Swartz@Dartmouth.edu.
authors.forename: Harold M
authors.initials: HM
authors.lastname: Swartz
authors.affiliation: Department of Radiology, Geisel School of Medicine at Dartmouth, One Medical Center Drive Lebanon, Lebanon, NH, USA.|Department of Medicine, Geisel School of Medicine at Dartmouth, One Medical Center Drive Lebanon, Lebanon, NH, USA.
authors.forename: Benjamin B
authors.initials: BB
authors.lastname: Williams
authors.affiliation: Department of Radiology, Geisel School of Medicine at Dartmouth, One Medical Center Drive Lebanon, Lebanon, NH, USA.
authors.forename: Huagang
authors.initials: H
authors.lastname: Hou
authors.affiliation: Department of Radiology, Geisel School of Medicine at Dartmouth, One Medical Center Drive Lebanon, Lebanon, NH, USA.
authors.forename: Nadeem
authors.initials: N
authors.lastname: Khan
authors.affiliation: Department of Medicine, Geisel School of Medicine at Dartmouth, One Medical Center Drive Lebanon, Lebanon, NH, USA.
authors.forename: Lesley A
authors.initials: LA
authors.lastname: Jarvis
authors.affiliation: Department of Surgery, Geisel School of Medicine at Dartmouth, One Medical Center Drive Lebanon, Lebanon, NH, USA.
authors.forename: Eunice Y
authors.initials: EY
authors.lastname: Chen
authors.affiliation: Department of Medicine, Geisel School of Medicine at Dartmouth, One Medical Center Drive Lebanon, Lebanon, NH, USA.
authors.forename: Philip E
authors.initials: PE
authors.lastname: Schaner
authors.affiliation: Department of Radiation Oncology, Emory Medical School, Atlanta, GA, USA.
authors.forename: Arif
authors.initials: A
authors.lastname: Ali
authors.affiliation: Louvain Drug Research Institute, Université Catholique de Louvain, Brussels, Belgium.
authors.forename: Bernard
authors.initials: B
authors.lastname: Gallez
authors.affiliation: Department of Radiology, Geisel School of Medicine at Dartmouth, One Medical Center Drive Lebanon, Lebanon, NH, USA.|Department of Medicine, Geisel School of Medicine at Dartmouth, One Medical Center Drive Lebanon, Lebanon, NH, USA.
authors.forename: Periannan
authors.initials: P
authors.lastname: Kuppusamy
authors.affiliation: Department of Radiology, Geisel School of Medicine at Dartmouth, One Medical Center Drive Lebanon, Lebanon, NH, USA.
authors.forename: Ann B
authors.initials: AB
authors.lastname: Flood
mesh_terms: D001530:Belgium; D014408:Biomarkers, Tumor / Q000378:metabolism*; D002244:Carbon / Q000008:administration & dosage*; D004578:Electron Spin Resonance Spectroscopy; D005845:Georgia; D006801:Humans; D008665:Metalloporphyrins / Q000008:administration & dosage*; D009369:Neoplasms / Q000378:metabolism / Q000473:pathology / Q000628:therapy*; D009513:New Hampshire; D010092:Oximetry / Q000379:methods*; D010100:Oxygen / Q000378:metabolism*; D010313:Partial Pressure; D011237:Predictive Value of Tests; D016896:Treatment Outcome; D000072258:Tumor Hypoxia; D059016:Tumor Microenvironment
chemical_list: D014408:Biomarkers, Tumor; D008665:Metalloporphyrins; C028433:chinese ink; C481390:lithium 5,9,14,18,23,27,32,36-octa-n-butoxy-2,3-naphthocyanine; D002244:Carbon; D010100:Oxygen
keywords: EPR; Hypoxia; Oximetry; Tumor pO2