title: Treatment in carbon monoxide poisoning patients with headache: a prospective, multicenter, double-blind, controlled clinical trial.
abstract: BACKGROUND
  There is a lack of specificity of the analgesic agents used to treat headache and underlying acute carbon monoxide poisoning.
  
  
  OBJECTIVE
  To compare effectiveness of "oxygen alone" vs "metoclopramide plus oxygen" vs "metamizole plus oxygen" therapy in treating carbon monoxide-induced headache.
  
  
  METHODS
  A prospective, multicenter, double-blind, controlled trial.
  
  
  METHODS
  Three emergency departments in Turkey.
  
  
  METHODS
  Adult carbon monoxide poisoning patients with headache.
  
  
  METHODS
  A total of 117 carbon monoxide-intoxicated patients with headache were randomized into 3 groups and assessed at baseline, 30 minutes, 90 minutes, and 4 hours.
  
  
  METHODS
  The primary outcome was patient-reported improvement rates for headache. Secondary end points included nausea, need for rescue medication during treatment, and reduction in carboxyhemoglobin levels.
  
  
  RESULTS
  During observation, there was no statistical difference between drug type and visual analog scale score change at 30 minutes, 90 minutes, or 4 hours, for either headache or nausea. No rescue medication was needed during the study period. The reduction in carboxyhemoglobin levels did not differ among the 3 groups.
  
  
  CONCLUSIONS
  The use of "oxygen alone" is as efficacious as "oxygen plus metoclopramide" or "oxygen plus metamizole sodium" in the treatment of carbon monoxide-induced headache.
authors.affiliation: Department of Emergency Medicine, Kanuni Sultan Suleyman Education and Research Hospital, Istanbul, Turkey. Electronic address: drtarik1977@gmail.com.
authors.forename: Tarik
authors.initials: T
authors.lastname: Ocak
authors.affiliation: Department of Emergency, Ataturk University Medical Faculty, Erzurum, Turkey. Electronic address: dret25@gmail.com.
authors.forename: Erdal
authors.initials: E
authors.lastname: Tekin
authors.affiliation: Department of Emergency, Bagcilar Research and Teaching Hospital, Istanbul, Turkey. Electronic address: drmustafabasturk@gmail.com.
authors.forename: Mustafa
authors.initials: M
authors.lastname: Basturk
authors.affiliation: Department of Emergency, Abant Izzet Baysal University Medical Faculty, Bolu, Turkey. Electronic address: drarifduran@gmail.com.
authors.forename: Arif
authors.initials: A
authors.lastname: Duran
authors.affiliation: Department of Emergency, Faculty of Medicine, Pamukkale University, Denizli, Turkey. Electronic address: aserinken@hotmail.com.
authors.forename: Mustafa
authors.initials: M
authors.lastname: Serinken
authors.affiliation: Department of Emergency, Ataturk University Medical Faculty, Erzurum, Turkey. Electronic address: mucahitemet@gmail.com.
authors.forename: Mucahit
authors.initials: M
authors.lastname: Emet
mesh_terms: D000328:Adult; D000700:Analgesics / Q000627:therapeutic use*; D002249:Carbon Monoxide Poisoning / Q000097:blood / Q000150:complications / Q000628:therapy*; D002263:Carboxyhemoglobin / Q000378:metabolism; D003131:Combined Modality Therapy; D004177:Dipyrone / Q000627:therapeutic use*; D065127:Dopamine D2 Receptor Antagonists / Q000627:therapeutic use*; D004311:Double-Blind Method; D005260:Female; D006261:Headache / Q000188:drug therapy* / Q000209:etiology; D006801:Humans; D008297:Male; D008787:Metoclopramide / Q000627:therapeutic use*; D008875:Middle Aged; D009325:Nausea / Q000209:etiology; D010102:Oxygen Inhalation Therapy; D010147:Pain Measurement; D011446:Prospective Studies; D055815:Young Adult
chemical_list: D000700:Analgesics; D065127:Dopamine D2 Receptor Antagonists; D004177:Dipyrone; D002263:Carboxyhemoglobin; D008787:Metoclopramide