title: Supercooling Self-Assembly of Magnetic Shelled Core/Shell Supraparticles.
abstract: Molecular self-assembly has emerged as a powerful technique for controlling the structure and properties of core/shell structured supraparticles. However, drug-loading capacities and therapeutic effects of self-assembled magnetic core/shell nanocarriers with magnetic nanoparticles in the core are limited by the intervention of the outer organic or inorganic shell, the aggregation of superparamagnetic nanoparticles, the narrowed inner cavity, etc. Here, we present a self-assembly approach based on rebalancing hydrogen bonds between components under a supercooling process to form a new core/shell nanoscale supraparticle with magnetic nanoparticles as the shell and a polysaccharide as a core. Compared with conventional iron oxide nanoparticles, this magnetic shelled core/shell nanoparticle possesses an optimized inner cavity and a loss-free outer magnetic property. Furthermore, we find that the drug-loaded magnetic shelled nanocarriers showed interesting in vitro release behaviors at different pH conditions, including "swelling-broken", "dissociating-broken", and "bursting-broken" modes. Our experiments demonstrate the novel design of the multifunctional hybrid nanostructure and provide a considerable potential for the biomedical applications.
authors.affiliation: School of Materials Science and Engineering, Key Laboratory of Advanced Technologies of Materials, Ministry of Education, Southwest Jiaotong University , Chengdu, 610031, P. R. China.
authors.forename: Xiaotong
authors.initials: X
authors.lastname: Zheng
authors.affiliation: School of Materials Science and Engineering, Key Laboratory of Advanced Technologies of Materials, Ministry of Education, Southwest Jiaotong University , Chengdu, 610031, P. R. China.
authors.forename: Bingyun
authors.initials: B
authors.lastname: Yan
authors.affiliation: School of Materials Science and Engineering, Key Laboratory of Advanced Technologies of Materials, Ministry of Education, Southwest Jiaotong University , Chengdu, 610031, P. R. China.
authors.forename: Fengluan
authors.initials: F
authors.lastname: Wu
authors.affiliation: School of Materials Science and Engineering, Key Laboratory of Advanced Technologies of Materials, Ministry of Education, Southwest Jiaotong University , Chengdu, 610031, P. R. China.
authors.forename: Jinlong
authors.initials: J
authors.lastname: Zhang
authors.affiliation: School of Materials Science and Engineering, Key Laboratory of Advanced Technologies of Materials, Ministry of Education, Southwest Jiaotong University , Chengdu, 610031, P. R. China.
authors.forename: Shuxin
authors.initials: S
authors.lastname: Qu
authors.affiliation: School of Materials Science and Engineering, Key Laboratory of Advanced Technologies of Materials, Ministry of Education, Southwest Jiaotong University , Chengdu, 610031, P. R. China.
authors.forename: Shaobing
authors.initials: S
authors.lastname: Zhou
authors.affiliation: School of Materials Science and Engineering, Key Laboratory of Advanced Technologies of Materials, Ministry of Education, Southwest Jiaotong University , Chengdu, 610031, P. R. China.
authors.forename: Jie
authors.initials: J
authors.lastname: Weng
keywords: core/shell; drug-loaded; magnetic shelled; self-assembly; supercooling