title: Mitotic exit: Determining the PP2A dephosphorylation program.
abstract: In mitotic exit, proteins that were highly phosphorylated are sequentially targeted by the phosphatase PP2A-B55, but what underlies substrate selection is unclear. In this issue, Cundell et al. (2016. J. Cell Biol http://dx.doi.org/10.1083/jcb.201606033) identify the determinants of PP2A-B55's dephosphorylation program, thereby influencing spindle disassembly, nuclear envelope reformation, and cytokinesis.
authors.affiliation: German Cancer Research Centre, DKFZ-ZMBH Alliance and Centre for Organismal Studies, University of Heidelberg, 69120 Heidelberg, Germany gislene.pereira@cos.uni-heidelberg.de e.schiebel@zmbh.uni-heidelberg.de.
authors.forename: Gislene
authors.identifier: 0000-0002-6233-8352
authors.initials: G
authors.lastname: Pereira
authors.affiliation: Zentrum für Molekulare Biologie der Universität Heidelberg, DKFZ-ZMBH Alliance, 69120 Heidelberg, Germany gislene.pereira@cos.uni-heidelberg.de e.schiebel@zmbh.uni-heidelberg.de.
authors.forename: Elmar
authors.initials: E
authors.lastname: Schiebel
mesh_terms: D006367:HeLa Cells; D006801:Humans; D008938:Mitosis; D008954:Models, Biological; D010766:Phosphorylation; D054648:Protein Phosphatase 2 / Q000378:metabolism*; D008941:Spindle Apparatus / Q000378:metabolism; D013379:Substrate Specificity
chemical_list: D054648:Protein Phosphatase 2