title: Increased risk of breast cancer in individuals carrying the TNRC9 rs3803662 C>T polymorphism: a meta-analysis of case-control studies.
abstract: Currently, the relationship between the trinucleotide repeat containing 9 (TNRC9) rs3803662 C>T polymorphism and risk of breast cancer (BC) is uncertain. Here, we attempted to obtain a more accurate assessment of this association by conducting a meta-analysis of all eligible case-control investigations, comprising 44,820 cases and 58,316 controls. A comprehensive search was performed to identify all suitable studies involving the TNRC9 rs3803662 polymorphism and BC risk. Pooled odds ratios (ORs) and 95% confidence intervals (95%CIs) were estimated using fixed- or random-effect models. Heterogeneity, publication bias, and sensitivity analyses were also carried out. We found that the variant T allele of rs3803662 C>T greatly increases BC risk (CT vs CC: OR = 1.14, 95%CI = 1.07-1.22, P < 0.001; TT vs CC: OR = 1.38, 95%CI = 1.25-1.53, P < 0.001; CT/TT vs CC: OR = 1.19, 95%CI = 1.11-1.28, P < 0.001; TT vs
  OR = 1.28, 95%CI = 1.19-1.38, P < 0.001). Stratified analysis based on ethnicity also revealed a markedly increased risk in Asian and Caucasian populations. Moreover, studies with hospital-based control groups showed elevated risk under the four genetic models employed, as did those using population-based controls, except under heterozygote comparison. The TNRC9 rs3803662 C>T polymorphism is greatly related to increased risk of BC, in both Asian and Caucasian populations.
authors.affiliation: Department of Oncology, Affiliated Jiangyin Hospital of Southeast University Medical College, Jiangyin, Jiangsu, China qiongwangdoc@163.com.
authors.forename: Q
authors.initials: Q
authors.lastname: Wang
authors.affiliation: Department of Oncology, Affiliated Jiangyin Hospital of Southeast University Medical College, Jiangyin, Jiangsu, China.
authors.forename: N Y
authors.initials: NY
authors.lastname: Wang
authors.affiliation: Department of Oncology, Affiliated Jiangyin Hospital of Southeast University Medical College, Jiangyin, Jiangsu, China.
authors.forename: X M
authors.initials: XM
authors.lastname: Cao
authors.affiliation: Department of Oncology, Affiliated Jiangyin Hospital of Southeast University Medical College, Jiangyin, Jiangsu, China.
authors.forename: X
authors.initials: X
authors.lastname: Sun
authors.affiliation: Department of Oncology, Affiliated Jiangyin Hospital of Southeast University Medical College, Jiangyin, Jiangsu, China.
authors.forename: D
authors.initials: D
authors.lastname: Shen
authors.affiliation: Department of Oncology, Affiliated Jiangyin Hospital of Southeast University Medical College, Jiangyin, Jiangsu, China.
authors.forename: M
authors.initials: M
authors.lastname: Yuan
authors.affiliation: Department of Oncology, Nanjing First Hospital, Nanjing Medical University, Nanjing, Jiangsu, China.
authors.forename: J F
authors.initials: JF
authors.lastname: Chen
mesh_terms: D051017:Apoptosis Regulatory Proteins; D001943:Breast Neoplasms / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006579:Heterozygote; D006609:High Mobility Group Proteins; D006801:Humans; D020641:Polymorphism, Single Nucleotide; D011980:Receptors, Progesterone / Q000235:genetics*; D012306:Risk; D015534:Trans-Activators
chemical_list: D051017:Apoptosis Regulatory Proteins; D006609:High Mobility Group Proteins; D011980:Receptors, Progesterone; C521752:TOX3 protein, human; D015534:Trans-Activators