title: Carboxylated graphene oxide functionalized with β-cyclodextrin-Engineering of a novel nanohybrid drug carrier.
abstract: In this paper, we selected biocompatible carboxylated graphene oxide (GeneO-COOH) as a base material. The nanohybrid drug carriers composed of GeneO-COOH and cyclodextrin (β-CD), have been successfully synthesized through esterification and self-assembly technique. The nanohybrid drug carriers of GeneO-COO-β-CD were characterized by X-ray diffraction (XRD), fourier infrared spectroscopy (FTIR), thermogravimetric analysis (TG), scanning electron microscopy (SEM), transmission electron microscopy (TEM) and solubility experiments. Results indicated that the nanohybrid was obtained with GeneO-COOH forming the core and a large number of β-CD molecules forming the shell with a special structure. In the nanohybrid, the westerification between GeneO-COOH and β-CD led to the formation of covalent bonds, while adjacent β-CD molecules engineer an outer shell composed of 100 β-CD molecules (ca. 800nm of thickness) in the form of a layer-by-layer self-assembly due to hydrogen-bonding interaction. The obtained novel nanohybrid drug carriers of GeneO-COO-β-CD possessed good dispersibility in water media and the solutions were found to remain stable for 12 months，providing a possibility for further applications in biology, medicine, agriculture and other fields.
authors.affiliation: Jiangsu Key Laboratory of Biofunctional Materials, College of Chemistry and Materials Science, Nanjing Normal University, Jiangsu Province, Nanjing 210046, China; Jiangsu Key Laboratory for Supramolecular Medicinal Materials and Applications, College of Life Science, Nanjing Normal University, Nanjing 210046, China.
authors.forename: Na
authors.initials: N
authors.lastname: Meng
authors.affiliation: Jiangsu Key Laboratory of Biofunctional Materials, College of Chemistry and Materials Science, Nanjing Normal University, Jiangsu Province, Nanjing 210046, China; Jiangsu Collaborative Innovation Center for Biological Functional Materials, Nanjing Normal University, Nanjing 210023, China.
authors.forename: YuTian
authors.initials: Y
authors.lastname: Su
authors.affiliation: Jiangsu Key Laboratory of Biofunctional Materials, College of Chemistry and Materials Science, Nanjing Normal University, Jiangsu Province, Nanjing 210046, China; Jiangsu Collaborative Innovation Center for Biological Functional Materials, Nanjing Normal University, Nanjing 210023, China; Nanjing Zhou Ninglin Advanced Materials Technology Company Limited, Jiangsu Province, Nanjing 211505, China. Electronic address: zhouninglin@njnu.edu.cn.
authors.forename: Ninglin
authors.initials: N
authors.lastname: Zhou
authors.affiliation: Jiangsu Key Laboratory of Biofunctional Materials, College of Chemistry and Materials Science, Nanjing Normal University, Jiangsu Province, Nanjing 210046, China; Jiangsu Collaborative Innovation Center for Biological Functional Materials, Nanjing Normal University, Nanjing 210023, China.
authors.forename: Ming
authors.initials: M
authors.lastname: Zhang
authors.affiliation: Jiangsu Key Laboratory of Biofunctional Materials, College of Chemistry and Materials Science, Nanjing Normal University, Jiangsu Province, Nanjing 210046, China; Jiangsu Collaborative Innovation Center for Biological Functional Materials, Nanjing Normal University, Nanjing 210023, China.
authors.forename: Maoni
authors.initials: M
authors.lastname: Shao
authors.affiliation: Jiangsu Key Laboratory of Biofunctional Materials, College of Chemistry and Materials Science, Nanjing Normal University, Jiangsu Province, Nanjing 210046, China; Jiangsu Collaborative Innovation Center for Biological Functional Materials, Nanjing Normal University, Nanjing 210023, China.
authors.forename: Yunting
authors.initials: Y
authors.lastname: Fan
authors.affiliation: Jiangsu Key Laboratory of Biofunctional Materials, College of Chemistry and Materials Science, Nanjing Normal University, Jiangsu Province, Nanjing 210046, China; Jiangsu Collaborative Innovation Center for Biological Functional Materials, Nanjing Normal University, Nanjing 210023, China.
authors.forename: Haomiao
authors.initials: H
authors.lastname: Zhu
authors.affiliation: Jiangsu Key Laboratory of Biofunctional Materials, College of Chemistry and Materials Science, Nanjing Normal University, Jiangsu Province, Nanjing 210046, China; Jiangsu Collaborative Innovation Center for Biological Functional Materials, Nanjing Normal University, Nanjing 210023, China.
authors.forename: Ping
authors.initials: P
authors.lastname: Yuan
authors.affiliation: Jiangsu Key Laboratory of Biofunctional Materials, College of Chemistry and Materials Science, Nanjing Normal University, Jiangsu Province, Nanjing 210046, China; Jiangsu Collaborative Innovation Center for Biological Functional Materials, Nanjing Normal University, Nanjing 210023, China.
authors.forename: Cheng
authors.initials: C
authors.lastname: Chi
authors.affiliation: Jiangsu Key Laboratory of Biofunctional Materials, College of Chemistry and Materials Science, Nanjing Normal University, Jiangsu Province, Nanjing 210046, China; Jiangsu Collaborative Innovation Center for Biological Functional Materials, Nanjing Normal University, Nanjing 210023, China. Electronic address: yhxiao@njnu.edu.cn.
authors.forename: Yinghong
authors.initials: Y
authors.lastname: Xiao
mesh_terms: D002264:Carboxylic Acids / Q000737:chemistry; D004337:Drug Carriers / Q000737:chemistry*; D004355:Drug Stability; D006108:Graphite / Q000737:chemistry*; D006860:Hydrogen Bonding; D057927:Hydrophobic and Hydrophilic Interactions; D058726:Nanoconjugates / Q000737:chemistry* / Q000648:ultrastructure; D010087:Oxides; D012995:Solubility; D047392:beta-Cyclodextrins / Q000737:chemistry*
chemical_list: D002264:Carboxylic Acids; D004337:Drug Carriers; D058726:Nanoconjugates; D010087:Oxides; D047392:beta-Cyclodextrins; D006108:Graphite
keywords: Carboxylated graphene oxide; Cyclodextrin; Nanohybrid