title: [PERSISTENT DRUG-INDUCED LIVER DAMAGES IN PATIENTS WITH PULMONARY TUBERCULOSIS].
abstract: The authors discuss the problem associated with the severe, persistent course of drug-induced liver disease slightly responsive to traditional treatment in patients receiving antituberculous therapy. The objective of the study was to reveal the essence and causes of drug-induced liver damage characterized by its severe, persistent course, evident clinical and laboratory manifestations, and a weak response to traditional therapy and to develop diagnostic principles. The severe, persistent course of drug-induced liver disease slightly responsive to traditional therapy was shown to be caused by a few competitive pathological processes occurring in the liver rather than failures in the therapeutic and diagnostic process. Prognostic criteria for the severe, persistent course of drug-induced liver disease slightly responsive to traditional therapy have been developed. A diagnostic algorithm is proposed.
mesh_terms: D000328:Adult; D000995:Antitubercular Agents / Q000008:administration & dosage / Q000009:adverse effects*; D056486:Chemical and Drug Induced Liver Injury / Q000175:diagnosis / Q000209:etiology / Q000503:physiopathology / Q000628:therapy; D018450:Disease Progression; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D000069451:Long Term Adverse Effects / Q000175:diagnosis / Q000503:physiopathology / Q000628:therapy; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D018570:Risk Assessment; D012720:Severity of Illness Index; D014397:Tuberculosis, Pulmonary / Q000188:drug therapy*
chemical_list: D000995:Antitubercular Agents