title: Assessment of arsenic in colostrum and cord serum and risk exposure to neonates from an island population in China.
abstract: Arsenic (As) has been proven to be highly toxic to humans, but limited attention has focused on exposure levels and potential risks to mother-neonate pairs of coastal populations. This study was conducted by examining the As concentration in colostrum and umbilical cord serum collected from 106 mother-neonate pairs living on Shengsi Island, facing the Yangtze River estuary and Hangzhou Bay in China. Average concentrations of total As in colostrum and cord serum were 18.51 ± 7.00 and 19.83 ± 10.50 μg L-1. One-way ANOVA analysis showed delivered ages and source of drinking water played significant roles in influencing the maternal exposure patterns. Correlation analysis indicated a significantly positive association between As concentrations in colostrum and cord serum. Multivariable linear regression models adjusted for other confounders clarified the dose-response relationship with a coefficient value of 0.23 and a 95 % confidence interval of (0.006, 0.492); p < 0.05. The calculated daily intake of total As for neonates through breastfeeding was in the range from 0.413 to 3.65 μg kg-1body weight, and colostrum As, especially the most toxic species, inorganic arsenic (iAs), would pose a risk to neonates.
authors.affiliation: MOE Key Laboratory of Environmental Remediation and Ecosystem Health, College of Environmental and Resource Sciences, Zhejiang University, Hangzhou, 310058, China.
authors.forename: Chenye
authors.initials: C
authors.lastname: Xu
authors.affiliation: MOE Key Laboratory of Environmental Remediation and Ecosystem Health, College of Environmental and Resource Sciences, Zhejiang University, Hangzhou, 310058, China.
authors.forename: Mengling
authors.initials: M
authors.lastname: Tang
authors.affiliation: MOE Key Laboratory of Environmental Remediation and Ecosystem Health, College of Environmental and Resource Sciences, Zhejiang University, Hangzhou, 310058, China.
authors.forename: Siyu
authors.initials: S
authors.lastname: Zhu
authors.affiliation: Department of Toxicology, School of Medicine and Public Health, Zhejiang University, Hangzhou, 310058, China.
authors.forename: Hua
authors.initials: H
authors.lastname: Naranmandura
authors.affiliation: MOE Key Laboratory of Environmental Remediation and Ecosystem Health, College of Environmental and Resource Sciences, Zhejiang University, Hangzhou, 310058, China. wliu@zju.edu.cn.
authors.forename: Weiping
authors.initials: W
authors.lastname: Liu
mesh_terms: D001151:Arsenic / Q000737:chemistry*; D002681:China; D003126:Colostrum / Q000737:chemistry*; D060766:Drinking Water / Q000032:analysis; D004781:Environmental Exposure; D063366:Estuaries; D005260:Female; D005312:Fetal Blood / Q000737:chemistry*; D006801:Humans; D007231:Infant, Newborn; D062312:Islands; D018811:Maternal Exposure; D011247:Pregnancy; D045483:Rivers; D014874:Water Pollutants, Chemical / Q000737:chemistry* / Q000378:metabolism
chemical_list: D060766:Drinking Water; D014874:Water Pollutants, Chemical; D001151:Arsenic
keywords: Arsenic; Colostrum; Correlation analysis; Exposure assessment; Inorganic arsenic speciation; Umbilical cord serum