title: Cysteinyl leukotriene correlated with 8-isoprostane levels as predictive biomarkers for sensory dysfunction in autism.
abstract: BACKGROUND
  Autism is a neurodevelopmental disorder that clinically presented as cognitive deficits, social impairments and sensory dysfunction. An increasing body of evidence has shown that oxidative stress and inflammation are involved in the pathophysiology of autism. Recording biomarkers as measure of the severity of autistic features might help in understanding the pathophysiology of autism.
  
  
  METHODS
  This study investigates the plasma levels of 8-isoprostane and Cysteinyl leukotrienes (CysLTs) in 44 autistic children and 40 healthy controls. The recruited autistic patients were assessed for behavior, cognitive and sensory deficits by using different autism severity rating scales, including the Childhood Autism Rating Scales (CARS), Social responsiveness scale (SRS) and Short Sensory Profile (SSP). Receiver Operating Characteristics analysis (ROC) of the obtained data was performed to measure the predictive value of 8-isoprostane and Cysteinyl leukotrienes (CysLTs) as oxidative stress- related parameters. Pearson's correlations between the measured parameters was also performed.
  
  
  RESULTS
  The concentrations of 8-isoprostane and CysLTs in autistic patients were significantly higher than those in controls. While cognitive and social impairments did not show any significant differences, the SSP results were strongly correlated with the levels of both of the biomarkers assessed. However, autistic children showed improvements in oxidative stress status (as determined by 8-isoprostane levels) at increasing ages.
  
  
  CONCLUSIONS
  This study indicates that 8-isoprostane and CysLTs can be used as markers for the early recognition of autistic patients through sensory deficits phenotypes which might help early intervention.
authors.affiliation: Biochemistry Department, Science College, King Saud University, P.O. Box 22452, Riyadh, 11495, Saudi Arabia.
authors.forename: Hanan
authors.initials: H
authors.lastname: Qasem
authors.affiliation: Autism Research and Treatment Center, Riyadh, Saudi Arabia.|Shaik AL-Amodi Autism Research Chair, King Saud University, Riyadh, Saudi Arabia.|Department of Physiology, Faculty of Medicine, King Saud University, Riyadh, Saudi Arabia.
authors.forename: Laila
authors.initials: L
authors.lastname: Al-Ayadhi
authors.affiliation: Central Laboratory, Female Center for Medical Studies and Scientific Section, King Saud University, Riyadh, KSA, Saudi Arabia. afafkelansary@gmail.com.|Autism Research and Treatment Center, Riyadh, Saudi Arabia. afafkelansary@gmail.com.|Shaik AL-Amodi Autism Research Chair, King Saud University, Riyadh, Saudi Arabia. afafkelansary@gmail.com.|Medicinal Chemistry Department, National Research Centre, Dokki, Cairo, Egypt. afafkelansary@gmail.com.
authors.forename: Afaf
authors.initials: A
authors.lastname: El-Ansary
mesh_terms: D001321:Autistic Disorder / Q000097:blood* / Q000503:physiopathology; D015415:Biomarkers / Q000097:blood; D002648:Child; D002675:Child, Preschool; D003545:Cysteine / Q000097:blood*; D015237:Dinoprost / Q000031:analogs & derivatives* / Q000097:blood; D005260:Female; D006801:Humans; D007249:Inflammation / Q000097:blood; D015289:Leukotrienes / Q000097:blood*; D008297:Male; D018384:Oxidative Stress / Q000502:physiology; D012678:Sensation Disorders / Q000097:blood* / Q000503:physiopathology; D012720:Severity of Illness Index
chemical_list: D015415:Biomarkers; D015289:Leukotrienes; C112381:cysteinyl-leukotriene; C075750:8-epi-prostaglandin F2alpha; D015237:Dinoprost; D003545:Cysteine
keywords: 8-isoprostane; Autism; Childhood autism rating scale; Cysteinyl leukotriene; Neuro-inflammation; Oxidative stress; Short sensory profile; Social responsiveness scale