title: Hypothalamic AMPK as a Regulator of Energy Homeostasis.
abstract: Activated in energy depletion conditions, AMP-activated protein kinase (AMPK) acts as a cellular energy sensor and regulator in both central nervous system and peripheral organs. Hypothalamic AMPK restores energy balance by promoting feeding behavior to increase energy intake, increasing glucose production, and reducing thermogenesis to decrease energy output. Besides energy state, many hormones have been shown to act in concert with AMPK to mediate their anorexigenic and orexigenic central effects as well as thermogenic influences. Here we explore the factors that affect hypothalamic AMPK activity and give the underlying mechanisms for the role of central AMPK in energy homeostasis together with the physiological effects of hypothalamic AMPK on energy balance restoration.
authors.affiliation: Departments of Pharmacology and Global Medical Science, Wonju College of Medicine, Yonsei University, Wonju 26426, Republic of Korea.
authors.forename: My Khanh Q
authors.initials: MK
authors.lastname: Huynh
authors.affiliation: Departments of Pharmacology and Global Medical Science, Wonju College of Medicine, Yonsei University, Wonju 26426, Republic of Korea.
authors.forename: Ann W
authors.initials: AW
authors.lastname: Kinyua
authors.affiliation: Departments of Pharmacology and Global Medical Science, Wonju College of Medicine, Yonsei University, Wonju 26426, Republic of Korea.
authors.forename: Dong Joo
authors.initials: DJ
authors.lastname: Yang
authors.affiliation: Departments of Pharmacology and Global Medical Science, Wonju College of Medicine, Yonsei University, Wonju 26426, Republic of Korea.
authors.forename: Ki Woo
authors.identifier: 0000-0002-7790-1515
authors.initials: KW
authors.lastname: Kim
mesh_terms: D055372:AMP-Activated Protein Kinases / Q000378:metabolism*; D000818:Animals; D004435:Eating / Q000502:physiology; D004734:Energy Metabolism / Q000502:physiology*; D005247:Feeding Behavior / Q000502:physiology*; D006706:Homeostasis / Q000502:physiology*; D006801:Humans; D007031:Hypothalamus / Q000378:metabolism*
chemical_list: D055372:AMP-Activated Protein Kinases