title: Mucinous Carcinoma with Neuroendocrine Differentiation of Salivary Gland Origin.
abstract: Primary mucinous adenocarcinomas of the salivary gland are rare malignancies defined by aggregates of epithelial cells suspended in large pools of extracellular mucin. We report a case of a giant mucinous adenocarcinoma of salivary gland origin, with low-grade cytoarchitectural features and neuroendocrine differentiation arising in the submental region. Grossly, the tumor measured 12.5 × 13.4 × 8.2 cm and replaced the bone and soft tissues of the anterior oral cavity. Microscopically, the neoplasm was composed of large extracellular pools of mucin, which contained papillary and acinar aggregates, and small nodules of ductal type epithelium with minimal nuclear enlargement, powdery chromatin and little pleomorphism. The nodules comprised 20 % of the tumor and showed morphologic and immunohistochemical evidence of neuroendocrine differentiation. Examination revealed histologic features comparable to mammary gland analogues in mucin predominance, ductal type morphology, expression of estrogen and progesterone receptors, and GATA-3 positivity. This is the first case reported of mucin-rich carcinoma of salivary gland origin exhibiting neuroendocrine differentiation.
authors.affiliation: Department of Surgery, Cedars-Sinai Medical Center, 8700 Beverly Blvd., Rm. 5537, Los Angeles, CA, 90048, USA.
authors.forename: Frankie K
authors.initials: FK
authors.lastname: Wong
authors.affiliation: Department of Radiation Oncology, Cedars-Sinai Medical Center, 8700 Beverly Blvd., Los Angeles, CA, 90048, USA.
authors.forename: Zachary S
authors.initials: ZS
authors.lastname: Zumsteg
authors.affiliation: Division of Plastic and Reconstructive Surgery, Department of Surgery, Cedars-Sinai Medical Center, 8700 Beverly Blvd., Los Angeles, CA, 90048, USA.
authors.forename: Claude-Jean
authors.initials: CJ
authors.lastname: Langevin
authors.affiliation: Department of Surgery, Cedars-Sinai Medical Center, 8700 Beverly Blvd., Rm. 5537, Los Angeles, CA, 90048, USA.
authors.forename: Nabilah
authors.initials: N
authors.lastname: Ali
authors.affiliation: Department of Pathology, Cedars-Sinai Medical Center, 8700 Beverly Blvd., Los Angeles, CA, 90048, USA.
authors.forename: Shawn
authors.initials: S
authors.lastname: Maclary
authors.affiliation: Department of Pathology, Cedars-Sinai Medical Center, 8700 Beverly Blvd., Los Angeles, CA, 90048, USA.
authors.forename: Bonnie L
authors.initials: BL
authors.lastname: Balzer
authors.affiliation: Department of Surgery, Cedars-Sinai Medical Center, 8700 Beverly Blvd., Rm. 5537, Los Angeles, CA, 90048, USA. allen.ho@cshs.org.
authors.forename: Allen S
authors.initials: AS
authors.lastname: Ho
mesh_terms: D002288:Adenocarcinoma, Mucinous / Q000473:pathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012468:Salivary Gland Neoplasms / Q000473:pathology*
keywords: Head and neck cancer; Mucin-rich carcinoma; Mucinous adenocarcinoma; Neuroendocrine differentiation; Reconstructive surgery; Salivary cancer; Salivary duct carcinoma