title: Bromfenac ophthalmic solution 0.09% as an adjunctive therapy to topical steroids after cataract surgery in pseudoexfoliation syndrome.
abstract: To study with laser flare photometry the antiinflammatory effect of bromfenac added to a topical steroid versus a topical steroid alone in patients with pseudoexfoliation (PXF) syndrome after cataract surgery.
  
  
  
  Ophthalmology Unit, Santa Maria Nuova Hospital, Reggio Emilia, Italy.
  
  
  
  Randomized clinical trial.
  
  
  
  Patients with cataract and clinical signs of PXF were randomized to dexamethasone 0.1% and tobramycin 0.3% ophthalmic solution (Group 1) or with the adjunct of bromfenac ophthalmic solution 0.09% (Group 2). All patients were examined on the day of surgery (baseline) and postoperatively at 1, 3, 7, and 30 days. Laser flare photometry was used to quantify anterior chamber inflammation and optical coherence tomography to measure macular thickness.
  
  
  
  Sixty-two patients were included. Postoperatively, the mean flare was 31% lower in Group 2 than in Group 1 at 3 days (11.92 ph/msec ± 8.14 [SD] versus 17.13 ± 9.03 ph/msec; P = .025) and 43% lower at 7 days (10.77 ± 6.17 ph/msec versus 18.72 ± 12.37 ph/msec; P = .003). There were no significant differences in postoperative visual acuity, symptoms, or ocular pain between groups. The mean macular thickness 1 month after surgery was increased in Group 1 but not Group 2; the difference between groups was significant at 4 weeks (P = .03). The incidence of intraretinal cysts was higher in Group 1 (n = 4) than in Group 2 (n = 0).
  
  
  
  The addition of bromfenac to topical steroids after cataract surgery in eyes with PXF was associated with greater reductions in inflammation than steroids alone.
  
  
  
  None of the authors has a financial or proprietary interest in any material or method mentioned.
authors.affiliation: From the Ophthalmology Unit (Coassin, Iovieno, Soldani, Cimino, Sartori, Fontana) and Clinical Trials and Statistics Unit (Cavuto, Formisano), Istituto di Ricerca e Cura a Carattere Scientifico-Arcispedale Santa Maria Nuova, Reggio Emilia, Italy.
authors.forename: Marco
authors.initials: M
authors.lastname: Coassin
authors.affiliation: From the Ophthalmology Unit (Coassin, Iovieno, Soldani, Cimino, Sartori, Fontana) and Clinical Trials and Statistics Unit (Cavuto, Formisano), Istituto di Ricerca e Cura a Carattere Scientifico-Arcispedale Santa Maria Nuova, Reggio Emilia, Italy.
authors.forename: Alfonso
authors.initials: A
authors.lastname: Iovieno
authors.affiliation: From the Ophthalmology Unit (Coassin, Iovieno, Soldani, Cimino, Sartori, Fontana) and Clinical Trials and Statistics Unit (Cavuto, Formisano), Istituto di Ricerca e Cura a Carattere Scientifico-Arcispedale Santa Maria Nuova, Reggio Emilia, Italy.
authors.forename: Anna
authors.initials: A
authors.lastname: Soldani
authors.affiliation: From the Ophthalmology Unit (Coassin, Iovieno, Soldani, Cimino, Sartori, Fontana) and Clinical Trials and Statistics Unit (Cavuto, Formisano), Istituto di Ricerca e Cura a Carattere Scientifico-Arcispedale Santa Maria Nuova, Reggio Emilia, Italy.
authors.forename: Silvio
authors.initials: S
authors.lastname: Cavuto
authors.affiliation: From the Ophthalmology Unit (Coassin, Iovieno, Soldani, Cimino, Sartori, Fontana) and Clinical Trials and Statistics Unit (Cavuto, Formisano), Istituto di Ricerca e Cura a Carattere Scientifico-Arcispedale Santa Maria Nuova, Reggio Emilia, Italy.
authors.forename: Luca
authors.initials: L
authors.lastname: Cimino
authors.affiliation: From the Ophthalmology Unit (Coassin, Iovieno, Soldani, Cimino, Sartori, Fontana) and Clinical Trials and Statistics Unit (Cavuto, Formisano), Istituto di Ricerca e Cura a Carattere Scientifico-Arcispedale Santa Maria Nuova, Reggio Emilia, Italy.
authors.forename: Antonio
authors.initials: A
authors.lastname: Sartori
authors.affiliation: From the Ophthalmology Unit (Coassin, Iovieno, Soldani, Cimino, Sartori, Fontana) and Clinical Trials and Statistics Unit (Cavuto, Formisano), Istituto di Ricerca e Cura a Carattere Scientifico-Arcispedale Santa Maria Nuova, Reggio Emilia, Italy.
authors.forename: Debora
authors.initials: D
authors.lastname: Formisano
authors.affiliation: From the Ophthalmology Unit (Coassin, Iovieno, Soldani, Cimino, Sartori, Fontana) and Clinical Trials and Statistics Unit (Cavuto, Formisano), Istituto di Ricerca e Cura a Carattere Scientifico-Arcispedale Santa Maria Nuova, Reggio Emilia, Italy. Electronic address: luigi.fontana@asmn.re.it.
authors.forename: Luigi
authors.initials: L
authors.lastname: Fontana
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage*; D001577:Benzophenones / Q000008:administration & dosage*; D001969:Bromobenzenes / Q000008:administration & dosage*; D002386:Cataract; D002387:Cataract Extraction; D017889:Exfoliation Syndrome / Q000188:drug therapy*; D006801:Humans; D019654:Lens Implantation, Intraocular; D009883:Ophthalmic Solutions / Q000008:administration & dosage*; D011183:Postoperative Complications
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D001577:Benzophenones; D001969:Bromobenzenes; D009883:Ophthalmic Solutions; C053083:bromfenac