title: Randomized clinical study of the peri-implant healing to hydrophilic and hydrophobic implant surfaces in patients receiving anticoagulants.
abstract: OBJECTIVE
  To compare the peri-implant bone healing between TiZr implants with hydrophilic SLActive and hydrophobic SLA implant surface in patients receiving anticoagulants, to assess the implant survival and success rate, as well as to evaluate whether small-diameter TiZr implants could be used in patients on OAT in order to avoid augmentation procedures.
  
  
  METHODS
  A total of 80 small-diameter tissue-level TiZr implants with SLActive and SLA surfaces were placed in 20 anticoagulated patients, following the "split-mouth" study design. Implant stability was measured up to the third postoperative month by resonance frequency measurements (RFA). One-year implant survival and success rate were evaluated.
  
  
  RESULTS
  After one year, 100% implant survival and success rate were observed. A significant decrease in ISQ comparing to baseline values was noted in the SLActive group from the first postoperative week, and in the SLA group, from the 3rd week after the surgery. In both groups, a statistically significant decline in ISQ was observed between second and third postoperative week. No significant differences in ISQ values between SLActive and SLA implants were noted, at any time point.
  
  
  CONCLUSIONS
  Titanium-zirconium small-diameter implants with SLActive and SLA surface predictably achieve and maintain adequate bone tissue integration in patients receiving anticoagulants. OAT appears to influence the bone healing events resulting in lower ISQ in the end of 3-month period in comparison with baseline values, although without compromising implant stability.
authors.affiliation: Department of Oral Surgery, School of Dental Medicine, University of Belgrade, Belgrade, Serbia.
authors.forename: Aleksa
authors.initials: A
authors.lastname: Marković
authors.affiliation: Department of Oral Surgery, School of Dental Medicine, University of Belgrade, Belgrade, Serbia.
authors.forename: Ana
authors.initials: A
authors.lastname: Đinić
authors.affiliation: Department of Research, International Dentistry Research Cathedra, UCAM Universidad Catolica San Antonio de Murcia, Murcia, Spain.
authors.forename: José Luis
authors.initials: JL
authors.lastname: Calvo Guirado
authors.affiliation: Department of Oral Implantology and Prosthetic Dentistry, Academic Center for Dentistry Amsterdam (ACTA), Move Research Institute, Amsterdam, The Netherlands.
authors.forename: Ali
authors.initials: A
authors.lastname: Tahmaseb
authors.affiliation: Department of Prosthodontics, School of Dental Medicine, University of Belgrade, Belgrade, Serbia.
authors.forename: Miodrag
authors.initials: M
authors.lastname: Šćepanović
authors.affiliation: Department of Oral Surgery, School of Dental Medicine, University of Belgrade, Belgrade, Serbia.
authors.forename: Bojan
authors.initials: B
authors.lastname: Janjić
mesh_terms: D000134:Acid Etching, Dental; D000368:Aged; D000925:Anticoagulants / Q000494:pharmacology*; D015921:Dental Implants; D017267:Dental Prosthesis Design; D005260:Female; D006801:Humans; D057927:Hydrophobic and Hydrophilic Interactions; D008297:Male; D008875:Middle Aged; D016348:Osseointegration / Q000187:drug effects*; D011446:Prospective Studies; D013499:Surface Properties / Q000187:drug effects; D000072836:Surgical Wound; D014025:Titanium; D014945:Wound Healing / Q000187:drug effects*; D015040:Zirconium
chemical_list: D000925:Anticoagulants; D015921:Dental Implants; D015040:Zirconium; D014025:Titanium
keywords: dental implant; implant stability; implant surface; oral anticoagulation therapy; titanium-zirconium