title: Illuminating T-cell Exhaustion.
abstract: Two studies have illuminated some of the molecular underpinnings of T-cell exhaustion. The first pinpoints the subset of exhausted T cells that revive upon PD-1 blockade. The second describes key metabolic deficiencies-restricted glucose uptake and mitochondrial dysfunction-that drive T cells to exhaustion.
mesh_terms: D000818:Animals; D000906:Antibodies / Q000494:pharmacology; D049109:Cell Proliferation / Q000187:drug effects; D051538:Hepatocyte Nuclear Factor 1-alpha / Q000378:metabolism; D006801:Humans; D008216:Lymphocytic Choriomeningitis; D008217:Lymphocytic choriomeningitis virus / Q000276:immunology / Q000378:metabolism; D051379:Mice; D008928:Mitochondria / Q000187:drug effects / Q000378:metabolism; D061026:Programmed Cell Death 1 Receptor / Q000037:antagonists & inhibitors* / Q000276:immunology; D054380:Receptors, CXCR5 / Q000378:metabolism; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology / Q000378:metabolism*
chemical_list: D000906:Antibodies; C513179:CXCR5 protein, mouse; D051538:Hepatocyte Nuclear Factor 1-alpha; C496488:Hnf1a protein, mouse; D061026:Programmed Cell Death 1 Receptor; D054380:Receptors, CXCR5