title: Reduced plasma levels of microtubule-associated STOP/MAP6 protein in autistic patients.
abstract: Autism is a neurodevelopmental disorder characterized by abnormal reciprocal social interactions, communication deficits and repetitive behaviors with restricted interests. A previous quantitative proteomic profiling study demonstrated that microtubule-associated stable tubule only polypeptide (STOP; also known as MAP6) protein was significant reduced in the cerebral cortex from BTBR mouse model of autism compared to the C57BL/6J mice. In the present study, the result showed that the concentration of STOP/MAP6 protein was significantly reduced in the plasma of autistic subjects than that in healthy controls. Finally, a possible mechanism of STOP/MAP6 protein in the pathogenesis of autism was proposed.
authors.affiliation: Department of Rehabilitation Medicine, Shanxi Provincial People's Hospital, Affiliate of Shanxi Medical University, 29 Shuangta Road, 030012 Taiyuan, China. Electronic address: hongenwei@gmail.com.
authors.forename: Hongen
authors.initials: H
authors.lastname: Wei
authors.affiliation: Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, 600 Wanping Nan Road, 200030 Shanghai, China.
authors.forename: Shibang
authors.initials: S
authors.lastname: Sun
authors.affiliation: Clinical Laboratory, Children's Hospital of Shanxi Province, Taiyuan, China.
authors.forename: Yonghong
authors.initials: Y
authors.lastname: Li
authors.affiliation: Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, 600 Wanping Nan Road, 200030 Shanghai, China. Electronic address: yushuny@yahoo.com.
authors.forename: Shunying
authors.initials: S
authors.lastname: Yu
mesh_terms: D000293:Adolescent; D001321:Autistic Disorder / Q000097:blood*; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D006801:Humans; D007223:Infant; D008869:Microtubule-Associated Proteins / Q000097:blood*; D040901:Proteomics
chemical_list: C491894:MAP6 protein, human; D008869:Microtubule-Associated Proteins
keywords: Autism; Hypothesis; STOP/MAP6 protein