title: [Hypovitaminosis D in Children with Hashimotos Thyroiditis].
abstract: BACKGROUND
  Vitamin D deficiency or insufficiency may play a role in the pathogenesis of certain autoimmune diseases.
  
  
  OBJECTIVE
  To measure vitamin D levels in children with Hashimotos thyroiditis (HT) (either with subclinical or marked hypothyroidism) and in healthy controls.
  
  
  METHODS
  We included 68 children with HT aged 12 ± 4 years (39 females) from a pediatric outpatient clinic and 68 healthy children aged 10 ± 4 years (37 females). Calcium metabolism parameters, thyroid function tests and anti-thyroid peroxidase (anti-TPO), anti-thyroglobulin (anti-TG) and 25 hydroxy vitamin D (25OHD) levels were measured.
  
  
  RESULTS
  Patients were older than controls but well matched by gender distribution. Mean 25OHD levels were significantly lower in HT patients than controls (16.8 ± 9.3 and 24.1 ± 9.4 ng/mL respectively, P < 0.01). Frequency of vitamin D deficiency was 76 and 35% in HT patients and controls, respectively (P < 0.001).
  
  
  CONCLUSIONS
  Vitamin D deficiency is more common in children with HT than healthy controls.
authors.forename: Ergün
authors.initials: E
authors.lastname: Sönmezgöz
authors.forename: Samet
authors.initials: S
authors.lastname: Ozer
authors.forename: Resul
authors.initials: R
authors.lastname: Yilmaz
authors.forename: Yalçın
authors.initials: Y
authors.lastname: Önder
authors.forename: Ilknur
authors.initials: I
authors.lastname: Bütün
authors.forename: Serap
authors.initials: S
authors.lastname: Bilge
mesh_terms: D015652:25-Hydroxyvitamin D 2 / Q000097:blood*; D001323:Autoantibodies / Q000097:blood* / Q000276:immunology; D016022:Case-Control Studies; D002648:Child; D005260:Female; D050031:Hashimoto Disease / Q000097:blood / Q000150:complications*; D006801:Humans; D007453:Iodide Peroxidase / Q000097:blood / Q000276:immunology; D008297:Male; D014808:Vitamin D Deficiency / Q000097:blood / Q000150:complications* / Q000175:diagnosis
chemical_list: D001323:Autoantibodies; C006606:anti-thyroglobulin; D015652:25-Hydroxyvitamin D 2; D007453:Iodide Peroxidase