title: Natural Killer Cell Reduction and Uteroplacental Vasculopathy.
abstract: Uterine natural killer cells are important for uteroplacental development and pregnancy maintenance. Their role in pregnancy disorders, such as preeclampsia, is unknown. We reduced the number of natural killer cells by administering rabbit anti-asialo GM1 antiserum in an established rat preeclamptic model (female human angiotensinogen×male human renin) and evaluated the effects at the end of pregnancy (day 21), compared with preeclamptic control rats receiving normal rabbit serum. In 100% of the antiserum-treated, preeclamptic rats (7/7), we observed highly degenerated vessel cross sections in the mesometrial triangle at the end of pregnancy. This maternal uterine vasculopathy was characterized by a total absence of nucleated/living cells in the vessel wall and perivascularly and prominent presence of fibrosis. Furthermore, there were no endovascular trophoblast cells within the vessel lumen. In the control, normal rabbit serum-treated, preeclamptic rats, only 20% (1/5) of the animals displayed such vasculopathy. We confirmed the results in healthy pregnant wild-type rats: after anti-asialo GM1 treatment, 67% of maternal rats displayed vasculopathy at the end of pregnancy compared with 0% in rabbit serum-treated control rats. This vasculopathy was associated with a significantly lower fetal weight in wild-type rats and deterioration of fetal brain/liver weight ratio in preeclamptic rats. Anti-asialo GM1 application had no influence on maternal hypertension and albuminuria during pregnancy. Our results show a new role of natural killer cells during hypertensive pregnancy in maintaining vascular integrity. In normotensive pregnancy, this integrity seems important for fetal growth.
authors.affiliation: From the Experimental and Clinical Research Center, a cooperation between the Max Delbrück Center for Molecular Medicine in the Helmholtz Association and the Charité - Universitätsmedizin Berlin, Germany (M.G., N.H., F.H., A.W., A.B., F.C.L., L.P., D.N.M., R.D.); Department of Obstetrics (M.G., S.V., W.H.) and Department of Gynecology (M.G.), Charité - Universitätsmedizin Berlin, Germany; Berlin Institute of Health (BIH), Germany (M.G., N.H., F.H., A.W., A.B., F.C.L., L.P., S.V., D.N.M., R.D.); Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany (N.H., F.H., A.B., D.N.M.); Charité - Universitätsmedizin Berlin, Campus Berlin Buch, Germany (A.W., F.C.L., L.P., R.D.); Department of Development and Regeneration, University Hospital Leuven, Belgium (L.V., R.P.); Department of Medical Biology, János Szentágothai Research Centre Pécs, University of Pécs Medical School, Hungary (A.B.); Department of Molecular Medicine, Institute of Basic Medical Sciences, University of Oslo, Norway (P.C.S., E.D.); Department of Multi-Disciplinary Laboratory Medicine and Medical Biochemistry, Akershus University Hospital, Lørenskog, Norway (P.C.S.); Clinic for Nephrology and Hypertension, Hannover Medical School, Germany (J.-K.P.); University of Oslo, Norway (P.A.-K., A.C.S.); Department of Obstetrics and Gynecology, Oslo University Hospital, Norway (P.A.-K., A.C.S.); and Department of Cardiology and Nephrology, HELIOS Klinikum Berlin, Germany (R.D.).
authors.forename: Michaela
authors.initials: M
authors.lastname: Golic
authors.affiliation: From the Experimental and Clinical Research Center, a cooperation between the Max Delbrück Center for Molecular Medicine in the Helmholtz Association and the Charité - Universitätsmedizin Berlin, Germany (M.G., N.H., F.H., A.W., A.B., F.C.L., L.P., D.N.M., R.D.); Department of Obstetrics (M.G., S.V., W.H.) and Department of Gynecology (M.G.), Charité - Universitätsmedizin Berlin, Germany; Berlin Institute of Health (BIH), Germany (M.G., N.H., F.H., A.W., A.B., F.C.L., L.P., S.V., D.N.M., R.D.); Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany (N.H., F.H., A.B., D.N.M.); Charité - Universitätsmedizin Berlin, Campus Berlin Buch, Germany (A.W., F.C.L., L.P., R.D.); Department of Development and Regeneration, University Hospital Leuven, Belgium (L.V., R.P.); Department of Medical Biology, János Szentágothai Research Centre Pécs, University of Pécs Medical School, Hungary (A.B.); Department of Molecular Medicine, Institute of Basic Medical Sciences, University of Oslo, Norway (P.C.S., E.D.); Department of Multi-Disciplinary Laboratory Medicine and Medical Biochemistry, Akershus University Hospital, Lørenskog, Norway (P.C.S.); Clinic for Nephrology and Hypertension, Hannover Medical School, Germany (J.-K.P.); University of Oslo, Norway (P.A.-K., A.C.S.); Department of Obstetrics and Gynecology, Oslo University Hospital, Norway (P.A.-K., A.C.S.); and Department of Cardiology and Nephrology, HELIOS Klinikum Berlin, Germany (R.D.).
authors.forename: Nadine
authors.initials: N
authors.lastname: Haase
authors.affiliation: From the Experimental and Clinical Research Center, a cooperation between the Max Delbrück Center for Molecular Medicine in the Helmholtz Association and the Charité - Universitätsmedizin Berlin, Germany (M.G., N.H., F.H., A.W., A.B., F.C.L., L.P., D.N.M., R.D.); Department of Obstetrics (M.G., S.V., W.H.) and Department of Gynecology (M.G.), Charité - Universitätsmedizin Berlin, Germany; Berlin Institute of Health (BIH), Germany (M.G., N.H., F.H., A.W., A.B., F.C.L., L.P., S.V., D.N.M., R.D.); Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany (N.H., F.H., A.B., D.N.M.); Charité - Universitätsmedizin Berlin, Campus Berlin Buch, Germany (A.W., F.C.L., L.P., R.D.); Department of Development and Regeneration, University Hospital Leuven, Belgium (L.V., R.P.); Department of Medical Biology, János Szentágothai Research Centre Pécs, University of Pécs Medical School, Hungary (A.B.); Department of Molecular Medicine, Institute of Basic Medical Sciences, University of Oslo, Norway (P.C.S., E.D.); Department of Multi-Disciplinary Laboratory Medicine and Medical Biochemistry, Akershus University Hospital, Lørenskog, Norway (P.C.S.); Clinic for Nephrology and Hypertension, Hannover Medical School, Germany (J.-K.P.); University of Oslo, Norway (P.A.-K., A.C.S.); Department of Obstetrics and Gynecology, Oslo University Hospital, Norway (P.A.-K., A.C.S.); and Department of Cardiology and Nephrology, HELIOS Klinikum Berlin, Germany (R.D.).
authors.forename: Florian
authors.initials: F
authors.lastname: Herse
authors.affiliation: From the Experimental and Clinical Research Center, a cooperation between the Max Delbrück Center for Molecular Medicine in the Helmholtz Association and the Charité - Universitätsmedizin Berlin, Germany (M.G., N.H., F.H., A.W., A.B., F.C.L., L.P., D.N.M., R.D.); Department of Obstetrics (M.G., S.V., W.H.) and Department of Gynecology (M.G.), Charité - Universitätsmedizin Berlin, Germany; Berlin Institute of Health (BIH), Germany (M.G., N.H., F.H., A.W., A.B., F.C.L., L.P., S.V., D.N.M., R.D.); Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany (N.H., F.H., A.B., D.N.M.); Charité - Universitätsmedizin Berlin, Campus Berlin Buch, Germany (A.W., F.C.L., L.P., R.D.); Department of Development and Regeneration, University Hospital Leuven, Belgium (L.V., R.P.); Department of Medical Biology, János Szentágothai Research Centre Pécs, University of Pécs Medical School, Hungary (A.B.); Department of Molecular Medicine, Institute of Basic Medical Sciences, University of Oslo, Norway (P.C.S., E.D.); Department of Multi-Disciplinary Laboratory Medicine and Medical Biochemistry, Akershus University Hospital, Lørenskog, Norway (P.C.S.); Clinic for Nephrology and Hypertension, Hannover Medical School, Germany (J.-K.P.); University of Oslo, Norway (P.A.-K., A.C.S.); Department of Obstetrics and Gynecology, Oslo University Hospital, Norway (P.A.-K., A.C.S.); and Department of Cardiology and Nephrology, HELIOS Klinikum Berlin, Germany (R.D.).
authors.forename: Anika
authors.initials: A
authors.lastname: Wehner
authors.affiliation: From the Experimental and Clinical Research Center, a cooperation between the Max Delbrück Center for Molecular Medicine in the Helmholtz Association and the Charité - Universitätsmedizin Berlin, Germany (M.G., N.H., F.H., A.W., A.B., F.C.L., L.P., D.N.M., R.D.); Department of Obstetrics (M.G., S.V., W.H.) and Department of Gynecology (M.G.), Charité - Universitätsmedizin Berlin, Germany; Berlin Institute of Health (BIH), Germany (M.G., N.H., F.H., A.W., A.B., F.C.L., L.P., S.V., D.N.M., R.D.); Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany (N.H., F.H., A.B., D.N.M.); Charité - Universitätsmedizin Berlin, Campus Berlin Buch, Germany (A.W., F.C.L., L.P., R.D.); Department of Development and Regeneration, University Hospital Leuven, Belgium (L.V., R.P.); Department of Medical Biology, János Szentágothai Research Centre Pécs, University of Pécs Medical School, Hungary (A.B.); Department of Molecular Medicine, Institute of Basic Medical Sciences, University of Oslo, Norway (P.C.S., E.D.); Department of Multi-Disciplinary Laboratory Medicine and Medical Biochemistry, Akershus University Hospital, Lørenskog, Norway (P.C.S.); Clinic for Nephrology and Hypertension, Hannover Medical School, Germany (J.-K.P.); University of Oslo, Norway (P.A.-K., A.C.S.); Department of Obstetrics and Gynecology, Oslo University Hospital, Norway (P.A.-K., A.C.S.); and Department of Cardiology and Nephrology, HELIOS Klinikum Berlin, Germany (R.D.).
authors.forename: Lisbeth
authors.initials: L
authors.lastname: Vercruysse
authors.affiliation: From the Experimental and Clinical Research Center, a cooperation between the Max Delbrück Center for Molecular Medicine in the Helmholtz Association and the Charité - Universitätsmedizin Berlin, Germany (M.G., N.H., F.H., A.W., A.B., F.C.L., L.P., D.N.M., R.D.); Department of Obstetrics (M.G., S.V., W.H.) and Department of Gynecology (M.G.), Charité - Universitätsmedizin Berlin, Germany; Berlin Institute of Health (BIH), Germany (M.G., N.H., F.H., A.W., A.B., F.C.L., L.P., S.V., D.N.M., R.D.); Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany (N.H., F.H., A.B., D.N.M.); Charité - Universitätsmedizin Berlin, Campus Berlin Buch, Germany (A.W., F.C.L., L.P., R.D.); Department of Development and Regeneration, University Hospital Leuven, Belgium (L.V., R.P.); Department of Medical Biology, János Szentágothai Research Centre Pécs, University of Pécs Medical School, Hungary (A.B.); Department of Molecular Medicine, Institute of Basic Medical Sciences, University of Oslo, Norway (P.C.S., E.D.); Department of Multi-Disciplinary Laboratory Medicine and Medical Biochemistry, Akershus University Hospital, Lørenskog, Norway (P.C.S.); Clinic for Nephrology and Hypertension, Hannover Medical School, Germany (J.-K.P.); University of Oslo, Norway (P.A.-K., A.C.S.); Department of Obstetrics and Gynecology, Oslo University Hospital, Norway (P.A.-K., A.C.S.); and Department of Cardiology and Nephrology, HELIOS Klinikum Berlin, Germany (R.D.).
authors.forename: Robert
authors.initials: R
authors.lastname: Pijnenborg
authors.affiliation: From the Experimental and Clinical Research Center, a cooperation between the Max Delbrück Center for Molecular Medicine in the Helmholtz Association and the Charité - Universitätsmedizin Berlin, Germany (M.G., N.H., F.H., A.W., A.B., F.C.L., L.P., D.N.M., R.D.); Department of Obstetrics (M.G., S.V., W.H.) and Department of Gynecology (M.G.), Charité - Universitätsmedizin Berlin, Germany; Berlin Institute of Health (BIH), Germany (M.G., N.H., F.H., A.W., A.B., F.C.L., L.P., S.V., D.N.M., R.D.); Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany (N.H., F.H., A.B., D.N.M.); Charité - Universitätsmedizin Berlin, Campus Berlin Buch, Germany (A.W., F.C.L., L.P., R.D.); Department of Development and Regeneration, University Hospital Leuven, Belgium (L.V., R.P.); Department of Medical Biology, János Szentágothai Research Centre Pécs, University of Pécs Medical School, Hungary (A.B.); Department of Molecular Medicine, Institute of Basic Medical Sciences, University of Oslo, Norway (P.C.S., E.D.); Department of Multi-Disciplinary Laboratory Medicine and Medical Biochemistry, Akershus University Hospital, Lørenskog, Norway (P.C.S.); Clinic for Nephrology and Hypertension, Hannover Medical School, Germany (J.-K.P.); University of Oslo, Norway (P.A.-K., A.C.S.); Department of Obstetrics and Gynecology, Oslo University Hospital, Norway (P.A.-K., A.C.S.); and Department of Cardiology and Nephrology, HELIOS Klinikum Berlin, Germany (R.D.).
authors.forename: Andras
authors.initials: A
authors.lastname: Balogh
authors.affiliation: From the Experimental and Clinical Research Center, a cooperation between the Max Delbrück Center for Molecular Medicine in the Helmholtz Association and the Charité - Universitätsmedizin Berlin, Germany (M.G., N.H., F.H., A.W., A.B., F.C.L., L.P., D.N.M., R.D.); Department of Obstetrics (M.G., S.V., W.H.) and Department of Gynecology (M.G.), Charité - Universitätsmedizin Berlin, Germany; Berlin Institute of Health (BIH), Germany (M.G., N.H., F.H., A.W., A.B., F.C.L., L.P., S.V., D.N.M., R.D.); Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany (N.H., F.H., A.B., D.N.M.); Charité - Universitätsmedizin Berlin, Campus Berlin Buch, Germany (A.W., F.C.L., L.P., R.D.); Department of Development and Regeneration, University Hospital Leuven, Belgium (L.V., R.P.); Department of Medical Biology, János Szentágothai Research Centre Pécs, University of Pécs Medical School, Hungary (A.B.); Department of Molecular Medicine, Institute of Basic Medical Sciences, University of Oslo, Norway (P.C.S., E.D.); Department of Multi-Disciplinary Laboratory Medicine and Medical Biochemistry, Akershus University Hospital, Lørenskog, Norway (P.C.S.); Clinic for Nephrology and Hypertension, Hannover Medical School, Germany (J.-K.P.); University of Oslo, Norway (P.A.-K., A.C.S.); Department of Obstetrics and Gynecology, Oslo University Hospital, Norway (P.A.-K., A.C.S.); and Department of Cardiology and Nephrology, HELIOS Klinikum Berlin, Germany (R.D.).
authors.forename: Per Christian
authors.initials: PC
authors.lastname: Saether
authors.affiliation: From the Experimental and Clinical Research Center, a cooperation between the Max Delbrück Center for Molecular Medicine in the Helmholtz Association and the Charité - Universitätsmedizin Berlin, Germany (M.G., N.H., F.H., A.W., A.B., F.C.L., L.P., D.N.M., R.D.); Department of Obstetrics (M.G., S.V., W.H.) and Department of Gynecology (M.G.), Charité - Universitätsmedizin Berlin, Germany; Berlin Institute of Health (BIH), Germany (M.G., N.H., F.H., A.W., A.B., F.C.L., L.P., S.V., D.N.M., R.D.); Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany (N.H., F.H., A.B., D.N.M.); Charité - Universitätsmedizin Berlin, Campus Berlin Buch, Germany (A.W., F.C.L., L.P., R.D.); Department of Development and Regeneration, University Hospital Leuven, Belgium (L.V., R.P.); Department of Medical Biology, János Szentágothai Research Centre Pécs, University of Pécs Medical School, Hungary (A.B.); Department of Molecular Medicine, Institute of Basic Medical Sciences, University of Oslo, Norway (P.C.S., E.D.); Department of Multi-Disciplinary Laboratory Medicine and Medical Biochemistry, Akershus University Hospital, Lørenskog, Norway (P.C.S.); Clinic for Nephrology and Hypertension, Hannover Medical School, Germany (J.-K.P.); University of Oslo, Norway (P.A.-K., A.C.S.); Department of Obstetrics and Gynecology, Oslo University Hospital, Norway (P.A.-K., A.C.S.); and Department of Cardiology and Nephrology, HELIOS Klinikum Berlin, Germany (R.D.).
authors.forename: Erik
authors.initials: E
authors.lastname: Dissen
authors.affiliation: From the Experimental and Clinical Research Center, a cooperation between the Max Delbrück Center for Molecular Medicine in the Helmholtz Association and the Charité - Universitätsmedizin Berlin, Germany (M.G., N.H., F.H., A.W., A.B., F.C.L., L.P., D.N.M., R.D.); Department of Obstetrics (M.G., S.V., W.H.) and Department of Gynecology (M.G.), Charité - Universitätsmedizin Berlin, Germany; Berlin Institute of Health (BIH), Germany (M.G., N.H., F.H., A.W., A.B., F.C.L., L.P., S.V., D.N.M., R.D.); Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany (N.H., F.H., A.B., D.N.M.); Charité - Universitätsmedizin Berlin, Campus Berlin Buch, Germany (A.W., F.C.L., L.P., R.D.); Department of Development and Regeneration, University Hospital Leuven, Belgium (L.V., R.P.); Department of Medical Biology, János Szentágothai Research Centre Pécs, University of Pécs Medical School, Hungary (A.B.); Department of Molecular Medicine, Institute of Basic Medical Sciences, University of Oslo, Norway (P.C.S., E.D.); Department of Multi-Disciplinary Laboratory Medicine and Medical Biochemistry, Akershus University Hospital, Lørenskog, Norway (P.C.S.); Clinic for Nephrology and Hypertension, Hannover Medical School, Germany (J.-K.P.); University of Oslo, Norway (P.A.-K., A.C.S.); Department of Obstetrics and Gynecology, Oslo University Hospital, Norway (P.A.-K., A.C.S.); and Department of Cardiology and Nephrology, HELIOS Klinikum Berlin, Germany (R.D.).
authors.forename: Friedrich C
authors.initials: FC
authors.lastname: Luft
authors.affiliation: From the Experimental and Clinical Research Center, a cooperation between the Max Delbrück Center for Molecular Medicine in the Helmholtz Association and the Charité - Universitätsmedizin Berlin, Germany (M.G., N.H., F.H., A.W., A.B., F.C.L., L.P., D.N.M., R.D.); Department of Obstetrics (M.G., S.V., W.H.) and Department of Gynecology (M.G.), Charité - Universitätsmedizin Berlin, Germany; Berlin Institute of Health (BIH), Germany (M.G., N.H., F.H., A.W., A.B., F.C.L., L.P., S.V., D.N.M., R.D.); Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany (N.H., F.H., A.B., D.N.M.); Charité - Universitätsmedizin Berlin, Campus Berlin Buch, Germany (A.W., F.C.L., L.P., R.D.); Department of Development and Regeneration, University Hospital Leuven, Belgium (L.V., R.P.); Department of Medical Biology, János Szentágothai Research Centre Pécs, University of Pécs Medical School, Hungary (A.B.); Department of Molecular Medicine, Institute of Basic Medical Sciences, University of Oslo, Norway (P.C.S., E.D.); Department of Multi-Disciplinary Laboratory Medicine and Medical Biochemistry, Akershus University Hospital, Lørenskog, Norway (P.C.S.); Clinic for Nephrology and Hypertension, Hannover Medical School, Germany (J.-K.P.); University of Oslo, Norway (P.A.-K., A.C.S.); Department of Obstetrics and Gynecology, Oslo University Hospital, Norway (P.A.-K., A.C.S.); and Department of Cardiology and Nephrology, HELIOS Klinikum Berlin, Germany (R.D.).
authors.forename: Lukasz
authors.initials: L
authors.lastname: Przybyl
authors.affiliation: From the Experimental and Clinical Research Center, a cooperation between the Max Delbrück Center for Molecular Medicine in the Helmholtz Association and the Charité - Universitätsmedizin Berlin, Germany (M.G., N.H., F.H., A.W., A.B., F.C.L., L.P., D.N.M., R.D.); Department of Obstetrics (M.G., S.V., W.H.) and Department of Gynecology (M.G.), Charité - Universitätsmedizin Berlin, Germany; Berlin Institute of Health (BIH), Germany (M.G., N.H., F.H., A.W., A.B., F.C.L., L.P., S.V., D.N.M., R.D.); Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany (N.H., F.H., A.B., D.N.M.); Charité - Universitätsmedizin Berlin, Campus Berlin Buch, Germany (A.W., F.C.L., L.P., R.D.); Department of Development and Regeneration, University Hospital Leuven, Belgium (L.V., R.P.); Department of Medical Biology, János Szentágothai Research Centre Pécs, University of Pécs Medical School, Hungary (A.B.); Department of Molecular Medicine, Institute of Basic Medical Sciences, University of Oslo, Norway (P.C.S., E.D.); Department of Multi-Disciplinary Laboratory Medicine and Medical Biochemistry, Akershus University Hospital, Lørenskog, Norway (P.C.S.); Clinic for Nephrology and Hypertension, Hannover Medical School, Germany (J.-K.P.); University of Oslo, Norway (P.A.-K., A.C.S.); Department of Obstetrics and Gynecology, Oslo University Hospital, Norway (P.A.-K., A.C.S.); and Department of Cardiology and Nephrology, HELIOS Klinikum Berlin, Germany (R.D.).
authors.forename: Joon-Keun
authors.initials: JK
authors.lastname: Park
authors.affiliation: From the Experimental and Clinical Research Center, a cooperation between the Max Delbrück Center for Molecular Medicine in the Helmholtz Association and the Charité - Universitätsmedizin Berlin, Germany (M.G., N.H., F.H., A.W., A.B., F.C.L., L.P., D.N.M., R.D.); Department of Obstetrics (M.G., S.V., W.H.) and Department of Gynecology (M.G.), Charité - Universitätsmedizin Berlin, Germany; Berlin Institute of Health (BIH), Germany (M.G., N.H., F.H., A.W., A.B., F.C.L., L.P., S.V., D.N.M., R.D.); Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany (N.H., F.H., A.B., D.N.M.); Charité - Universitätsmedizin Berlin, Campus Berlin Buch, Germany (A.W., F.C.L., L.P., R.D.); Department of Development and Regeneration, University Hospital Leuven, Belgium (L.V., R.P.); Department of Medical Biology, János Szentágothai Research Centre Pécs, University of Pécs Medical School, Hungary (A.B.); Department of Molecular Medicine, Institute of Basic Medical Sciences, University of Oslo, Norway (P.C.S., E.D.); Department of Multi-Disciplinary Laboratory Medicine and Medical Biochemistry, Akershus University Hospital, Lørenskog, Norway (P.C.S.); Clinic for Nephrology and Hypertension, Hannover Medical School, Germany (J.-K.P.); University of Oslo, Norway (P.A.-K., A.C.S.); Department of Obstetrics and Gynecology, Oslo University Hospital, Norway (P.A.-K., A.C.S.); and Department of Cardiology and Nephrology, HELIOS Klinikum Berlin, Germany (R.D.).
authors.forename: Patji
authors.initials: P
authors.lastname: Alnaes-Katjavivi
authors.affiliation: From the Experimental and Clinical Research Center, a cooperation between the Max Delbrück Center for Molecular Medicine in the Helmholtz Association and the Charité - Universitätsmedizin Berlin, Germany (M.G., N.H., F.H., A.W., A.B., F.C.L., L.P., D.N.M., R.D.); Department of Obstetrics (M.G., S.V., W.H.) and Department of Gynecology (M.G.), Charité - Universitätsmedizin Berlin, Germany; Berlin Institute of Health (BIH), Germany (M.G., N.H., F.H., A.W., A.B., F.C.L., L.P., S.V., D.N.M., R.D.); Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany (N.H., F.H., A.B., D.N.M.); Charité - Universitätsmedizin Berlin, Campus Berlin Buch, Germany (A.W., F.C.L., L.P., R.D.); Department of Development and Regeneration, University Hospital Leuven, Belgium (L.V., R.P.); Department of Medical Biology, János Szentágothai Research Centre Pécs, University of Pécs Medical School, Hungary (A.B.); Department of Molecular Medicine, Institute of Basic Medical Sciences, University of Oslo, Norway (P.C.S., E.D.); Department of Multi-Disciplinary Laboratory Medicine and Medical Biochemistry, Akershus University Hospital, Lørenskog, Norway (P.C.S.); Clinic for Nephrology and Hypertension, Hannover Medical School, Germany (J.-K.P.); University of Oslo, Norway (P.A.-K., A.C.S.); Department of Obstetrics and Gynecology, Oslo University Hospital, Norway (P.A.-K., A.C.S.); and Department of Cardiology and Nephrology, HELIOS Klinikum Berlin, Germany (R.D.).
authors.forename: Anne Cathrine
authors.initials: AC
authors.lastname: Staff
authors.affiliation: From the Experimental and Clinical Research Center, a cooperation between the Max Delbrück Center for Molecular Medicine in the Helmholtz Association and the Charité - Universitätsmedizin Berlin, Germany (M.G., N.H., F.H., A.W., A.B., F.C.L., L.P., D.N.M., R.D.); Department of Obstetrics (M.G., S.V., W.H.) and Department of Gynecology (M.G.), Charité - Universitätsmedizin Berlin, Germany; Berlin Institute of Health (BIH), Germany (M.G., N.H., F.H., A.W., A.B., F.C.L., L.P., S.V., D.N.M., R.D.); Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany (N.H., F.H., A.B., D.N.M.); Charité - Universitätsmedizin Berlin, Campus Berlin Buch, Germany (A.W., F.C.L., L.P., R.D.); Department of Development and Regeneration, University Hospital Leuven, Belgium (L.V., R.P.); Department of Medical Biology, János Szentágothai Research Centre Pécs, University of Pécs Medical School, Hungary (A.B.); Department of Molecular Medicine, Institute of Basic Medical Sciences, University of Oslo, Norway (P.C.S., E.D.); Department of Multi-Disciplinary Laboratory Medicine and Medical Biochemistry, Akershus University Hospital, Lørenskog, Norway (P.C.S.); Clinic for Nephrology and Hypertension, Hannover Medical School, Germany (J.-K.P.); University of Oslo, Norway (P.A.-K., A.C.S.); Department of Obstetrics and Gynecology, Oslo University Hospital, Norway (P.A.-K., A.C.S.); and Department of Cardiology and Nephrology, HELIOS Klinikum Berlin, Germany (R.D.).
authors.forename: Stefan
authors.initials: S
authors.lastname: Verlohren
authors.affiliation: From the Experimental and Clinical Research Center, a cooperation between the Max Delbrück Center for Molecular Medicine in the Helmholtz Association and the Charité - Universitätsmedizin Berlin, Germany (M.G., N.H., F.H., A.W., A.B., F.C.L., L.P., D.N.M., R.D.); Department of Obstetrics (M.G., S.V., W.H.) and Department of Gynecology (M.G.), Charité - Universitätsmedizin Berlin, Germany; Berlin Institute of Health (BIH), Germany (M.G., N.H., F.H., A.W., A.B., F.C.L., L.P., S.V., D.N.M., R.D.); Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany (N.H., F.H., A.B., D.N.M.); Charité - Universitätsmedizin Berlin, Campus Berlin Buch, Germany (A.W., F.C.L., L.P., R.D.); Department of Development and Regeneration, University Hospital Leuven, Belgium (L.V., R.P.); Department of Medical Biology, János Szentágothai Research Centre Pécs, University of Pécs Medical School, Hungary (A.B.); Department of Molecular Medicine, Institute of Basic Medical Sciences, University of Oslo, Norway (P.C.S., E.D.); Department of Multi-Disciplinary Laboratory Medicine and Medical Biochemistry, Akershus University Hospital, Lørenskog, Norway (P.C.S.); Clinic for Nephrology and Hypertension, Hannover Medical School, Germany (J.-K.P.); University of Oslo, Norway (P.A.-K., A.C.S.); Department of Obstetrics and Gynecology, Oslo University Hospital, Norway (P.A.-K., A.C.S.); and Department of Cardiology and Nephrology, HELIOS Klinikum Berlin, Germany (R.D.).
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Henrich
authors.affiliation: From the Experimental and Clinical Research Center, a cooperation between the Max Delbrück Center for Molecular Medicine in the Helmholtz Association and the Charité - Universitätsmedizin Berlin, Germany (M.G., N.H., F.H., A.W., A.B., F.C.L., L.P., D.N.M., R.D.); Department of Obstetrics (M.G., S.V., W.H.) and Department of Gynecology (M.G.), Charité - Universitätsmedizin Berlin, Germany; Berlin Institute of Health (BIH), Germany (M.G., N.H., F.H., A.W., A.B., F.C.L., L.P., S.V., D.N.M., R.D.); Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany (N.H., F.H., A.B., D.N.M.); Charité - Universitätsmedizin Berlin, Campus Berlin Buch, Germany (A.W., F.C.L., L.P., R.D.); Department of Development and Regeneration, University Hospital Leuven, Belgium (L.V., R.P.); Department of Medical Biology, János Szentágothai Research Centre Pécs, University of Pécs Medical School, Hungary (A.B.); Department of Molecular Medicine, Institute of Basic Medical Sciences, University of Oslo, Norway (P.C.S., E.D.); Department of Multi-Disciplinary Laboratory Medicine and Medical Biochemistry, Akershus University Hospital, Lørenskog, Norway (P.C.S.); Clinic for Nephrology and Hypertension, Hannover Medical School, Germany (J.-K.P.); University of Oslo, Norway (P.A.-K., A.C.S.); Department of Obstetrics and Gynecology, Oslo University Hospital, Norway (P.A.-K., A.C.S.); and Department of Cardiology and Nephrology, HELIOS Klinikum Berlin, Germany (R.D.).
authors.forename: Dominik N
authors.initials: DN
authors.lastname: Muller
authors.affiliation: From the Experimental and Clinical Research Center, a cooperation between the Max Delbrück Center for Molecular Medicine in the Helmholtz Association and the Charité - Universitätsmedizin Berlin, Germany (M.G., N.H., F.H., A.W., A.B., F.C.L., L.P., D.N.M., R.D.); Department of Obstetrics (M.G., S.V., W.H.) and Department of Gynecology (M.G.), Charité - Universitätsmedizin Berlin, Germany; Berlin Institute of Health (BIH), Germany (M.G., N.H., F.H., A.W., A.B., F.C.L., L.P., S.V., D.N.M., R.D.); Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany (N.H., F.H., A.B., D.N.M.); Charité - Universitätsmedizin Berlin, Campus Berlin Buch, Germany (A.W., F.C.L., L.P., R.D.); Department of Development and Regeneration, University Hospital Leuven, Belgium (L.V., R.P.); Department of Medical Biology, János Szentágothai Research Centre Pécs, University of Pécs Medical School, Hungary (A.B.); Department of Molecular Medicine, Institute of Basic Medical Sciences, University of Oslo, Norway (P.C.S., E.D.); Department of Multi-Disciplinary Laboratory Medicine and Medical Biochemistry, Akershus University Hospital, Lørenskog, Norway (P.C.S.); Clinic for Nephrology and Hypertension, Hannover Medical School, Germany (J.-K.P.); University of Oslo, Norway (P.A.-K., A.C.S.); Department of Obstetrics and Gynecology, Oslo University Hospital, Norway (P.A.-K., A.C.S.); and Department of Cardiology and Nephrology, HELIOS Klinikum Berlin, Germany (R.D.). ralf.dechend@charite.de.
authors.forename: Ralf
authors.initials: R
authors.lastname: Dechend
mesh_terms: D000704:Analysis of Variance; D000808:Angiotensinogen / Q000378:metabolism; D000818:Animals; D002465:Cell Movement / Q000187:drug effects / Q000502:physiology; D005260:Female; D047109:Fetal Development / Q000276:immunology / Q000502:physiology; D005865:Gestational Age; D019409:Interleukin-15 / Q000378:metabolism; D007694:Killer Cells, Natural / Q000166:cytology* / Q000276:immunology; D021041:Placental Circulation / Q000276:immunology / Q000502:physiology*; D011225:Pre-Eclampsia / Q000378:metabolism / Q000503:physiopathology*; D011247:Pregnancy; D011270:Pregnancy, Animal; D051381:Rats; D017207:Rats, Sprague-Dawley; D018709:Statistics, Nonparametric; D014327:Trophoblasts / Q000166:cytology* / Q000378:metabolism
chemical_list: D019409:Interleukin-15; D000808:Angiotensinogen
keywords: angiotensinogen; immunity; natural killer cells; preeclampsia; rat