title: Intra-articular bone marrow concentrate injection protocol: short-term efficacy in osteoarthritis.
abstract: Evaluate intra-articular injection of bone marrow concentrate (BMC), followed by platelet-rich plasma (PRP) injection at 8 weeks follow-up in moderate/severe osteoarthritis.
  
  
  
  Single center, retrospective Case Series (n = 125).
  
  
  
  Bone marrow was aspirated/concentrated using a standardized technique. Patients received a single intra-articular injection of BMC, with follow-up injection of PRP at 8 weeks.
  
  
  
  Median absolute pain reduction in all joints was five points (71.4%) on visual analog scale. Median patient satisfaction was 9.0/10, while 91.7% indicated that they would repeat the procedure and 94% said that they would recommend the procedure to a friend.
  
  
  
  Intra-articular injection of BMC, followed by a PRP injection, can provide short-term benefits in moderate-to-severe osteoarthritis.
authors.affiliation: David Geffen School of Medicine at UCLA; 10833 Le Conte Ave, Los Angeles, CA 90095, USA.|Western University of Health Sciences; 309 E 2nd St, Pomona, CA 91766, USA.|Touro College of Osteopathic Medicine, 230 W 125th St #1, NY 10027, USA.|The Orthobiologic Institute (TOBI), Woodland Hills, CA 91365, USA.
authors.forename: Steven
authors.initials: S
authors.lastname: Sampson
authors.affiliation: Departments of PM&R, Radiology & Anatomy, Mayo Clinic Sports Medicine Center, Mayo Clinic College of Medicine; 200 1st St SW, Rochester, MN 55905, USA.
authors.forename: Jay
authors.initials: J
authors.lastname: Smith
authors.affiliation: UC Davis Medical Center, Department of Physical Medicine & Rehabilitation; 4860 Y St, Med Center, Sacramento, CA 95817, USA.
authors.forename: Hunter
authors.initials: H
authors.lastname: Vincent
authors.affiliation: David Geffen School of Medicine at UCLA; 10833 Le Conte Ave, Los Angeles, CA 90095, USA.|Western University of Health Sciences; 309 E 2nd St, Pomona, CA 91766, USA.|Touro College of Osteopathic Medicine, 230 W 125th St #1, NY 10027, USA.|The Orthobiologic Institute (TOBI), Woodland Hills, CA 91365, USA.
authors.forename: Danielle
authors.initials: D
authors.lastname: Aufiero
authors.affiliation: Greater Los Angeles VA Medical Center, Department of Physical Medicine & Rehabilitation; 11301 Wilshire Blvd, Los Angeles, CA 90073, USA.
authors.forename: Mona
authors.initials: M
authors.lastname: Zall
authors.affiliation: Musculoskeletal Research International, Clinical Research Experts; 1004 Avocado Isle, Ft. Lauderdale, FL 33315, USA.
authors.forename: Angie
authors.initials: A
authors.lastname: Botto-van-Bemden
mesh_terms: D000328:Adult; D000368:Aged; D001854:Bone Marrow Cells / Q000166:cytology*; D005260:Female; D006801:Humans; D007270:Injections, Intra-Articular / Q000379:methods*; D008297:Male; D008875:Middle Aged; D010003:Osteoarthritis / Q000628:therapy*; D010146:Pain / Q000517:prevention & control*; D010147:Pain Measurement; D012189:Retrospective Studies; D016896:Treatment Outcome; D055815:Young Adult
keywords: bone marrow concentrate; orthobiologics; osteoarthritis; platelet-rich plasma