title: Primary micropapillary carcinoma of the colon with submucosal invasion: A case report.
abstract: We present a case of invasive micropapillary carcinoma (IMPC) of the colon treated by endoscopic resection following magnifying endoscopy. A 47-year-old woman visited our hospital for follow-up of a positive fecal occult blood test. Colonoscopy revealed a semi-pedunculated reddish polyp, the surface of which showed gentle irregularity, and mild tension in the sigmoid colon. Magnifying colonoscopy with narrow band imaging revealed an irregular surface pattern with heterogeneity in vascular diameter and distribution. Magnifying endoscopic findings using crystal violet staining showed an irregular pit pattern with an expansion of stromal areas. Endoscopic resection of the sigmoid colon tumor was performed, and the histology of the resected specimen primarily revealed a micropapillary component with a small moderately differentiated adenocarcinoma component that massively invaded into the submucosal layer, accompanied by lymphatic invasion, although the tumor was very small (7 mm in diameter, smaller than any in previous reports). Laparoscopy-assisted sigmoidectomy and regional lymph node resection were performed; neither cancer nor lymph node metastases were present. This is the first report of a case with early-stage colonic IMPC observed with magnifying colonoscopy.
authors.affiliation: Division of Endoscopy, Shimane Prefectural Central Hospital, Shimane, Japan.
authors.forename: Youichi
authors.initials: Y
authors.lastname: Miyaoka
authors.affiliation: Division of Gastroenterology, Shimane Prefectural Central Hospital, Shimane, Japan.
authors.forename: Aya
authors.initials: A
authors.lastname: Fujiwara
authors.affiliation: Division of Gastroenterology, Shimane Prefectural Central Hospital, Shimane, Japan.
authors.forename: Satoshi
authors.initials: S
authors.lastname: Kotani
authors.affiliation: Division of Gastroenterology, Shimane Prefectural Central Hospital, Shimane, Japan.
authors.forename: Kosuke
authors.initials: K
authors.lastname: Tsukano
authors.affiliation: Division of Gastroenterology, Shimane Prefectural Central Hospital, Shimane, Japan.
authors.forename: Sayaka
authors.initials: S
authors.lastname: Ogawa
authors.affiliation: Division of Gastroenterology, Shimane Prefectural Central Hospital, Shimane, Japan.
authors.forename: Satoshi
authors.initials: S
authors.lastname: Yamanouchi
authors.affiliation: Division of Gastroenterology, Shimane Prefectural Central Hospital, Shimane, Japan.
authors.forename: Ryusaku
authors.initials: R
authors.lastname: Kusunoki
authors.affiliation: Division of Endoscopy, Shimane Prefectural Central Hospital, Shimane, Japan.
authors.forename: Hirofumi
authors.initials: H
authors.lastname: Fujishiro
authors.affiliation: Division of Gastroenterology, Shimane Prefectural Central Hospital, Shimane, Japan.
authors.forename: Naruaki
authors.initials: N
authors.lastname: Kohge
authors.affiliation: Division of Pathology, Shimane Prefectural Central Hospital, Shimane, Japan.
authors.forename: Tomohiko
authors.initials: T
authors.lastname: Yamamoto
authors.affiliation: Division of Endoscopy, Kaken Hospital, International University of Health and Welfare, Chiba, Japan.
authors.forename: Yuji
authors.initials: Y
authors.lastname: Amano