title: Impact of hospitalizations for bronchiolitis in preterm infants on long-term health care costs in Italy: a retrospective case-control study.
abstract: OBJECTIVE
  Bronchiolitis is an acute inflammatory injury of the bronchioles, and is the most frequent cause of hospitalization for lower respiratory tract infections in preterm infants. This was a retrospective, observational, case-control study conducted in Italy, based on administrative database analysis. The aim of this study was to evaluate differences in health care costs of preterm infants with and without early hospitalization for bronchiolitis.
  
  
  METHODS
  Preterm infants born in the period between January 1, 2009 and December 31, 2010 and hospitalized for bronchiolitis in the first year of life were selected from the ARNO Observatory database and observed for the first 4 years of life. These preterm infants were compared (paired 1-3) with preterm infants who were not hospitalized for bronchiolitis in the first year of life and with similar characteristics. Only direct health care costs reimbursed by the Italian National Health Service were considered for this study (drugs, hospitalizations, and diagnostic/therapeutic procedures).
  
  
  RESULTS
  Of 40,823 newborns in the accrual period, 863 were preterm with no evidence of prophylaxis, and 22 preterm infants were hospitalized for bronchiolitis (cases) and paired with 62 controls. Overall, cases had 74% higher average cost per infant in the first 4 years of life than controls (18,624€ versus 10,189€, respectively). The major cost drivers were hospitalizations, accounting for >90% in both the populations. The increase in total yearly health care cost between cases and controls remained substantial even in the fourth year of life for all cost items. A relevant increase in hospitalizations and drug consumption linked to respiratory tract diseases was noted in infants hospitalized for bronchiolitis during the entire follow-up period.
  
  
  CONCLUSIONS
  Preterm infants hospitalized for bronchiolitis in the first year of life were associated with increased resource consumption and costs throughout the entire period of observation; even in the fourth year, the difference versus paired controls was relevant.
authors.affiliation: ProCure Solutions, Nembro, Bergamo.
authors.forename: Daniela Paola
authors.initials: DP
authors.lastname: Roggeri
authors.affiliation: ProCure Solutions, Nembro, Bergamo.
authors.forename: Alessandro
authors.initials: A
authors.lastname: Roggeri
authors.affiliation: CINECA Interuniversity Consortium, Bologna.
authors.forename: Elisa
authors.initials: E
authors.lastname: Rossi
authors.affiliation: CINECA Interuniversity Consortium, Bologna.
authors.forename: Salvatore
authors.initials: S
authors.lastname: Cataudella
authors.affiliation: Accademia Nazionale di Medicina, Rome, Italy.
authors.forename: Nello
authors.initials: N
authors.lastname: Martini
keywords: bronchiolitis; cost; hospitalizations; preterm