title: Exploiting Noncovalent Interactions in an Imine-Based Covalent Organic Framework for Quercetin Delivery.
abstract: Covalent organic frameworks (COFs) are a new class of nanoporous polymeric vector showing promise as drug-delivery vehicles with high loading capacity and biocompatibility. The interaction between the carrier and the cargo is specifically tailored on a molecular level by H-bonding. Cell-proliferation studies indicate higher efficacy of the drug in cancer cells by nanocarrier delivery mediated by the COF.
authors.affiliation: Max Planck Institute for Solid State Research, Heisenbergstrasse 1, 70569, Stuttgart, Germany.
authors.forename: Vijay S
authors.initials: VS
authors.lastname: Vyas
authors.affiliation: Department of New Materials and Biosystems, Max Planck Institute for Intelligent Systems, Stuttgart, 70569, Germany.|Department of Biophysical Chemistry, University of Heidelberg, Heidelberg, 69120, Germany.
authors.forename: Medhavi
authors.initials: M
authors.lastname: Vishwakarma
authors.affiliation: Max Planck Institute for Solid State Research, Heisenbergstrasse 1, 70569, Stuttgart, Germany.
authors.forename: Igor
authors.initials: I
authors.lastname: Moudrakovski
authors.affiliation: Max Planck Institute for Solid State Research, Heisenbergstrasse 1, 70569, Stuttgart, Germany.|Department of Chemistry, University of Munich (LMU), Butenandtstrasse 5-13, 81377, Munich, Germany.
authors.forename: Frederik
authors.initials: F
authors.lastname: Haase
authors.affiliation: Department of Chemistry, University of Munich (LMU), Butenandtstrasse 5-13, 81377, Munich, Germany.
authors.forename: Gökcen
authors.initials: G
authors.lastname: Savasci
authors.affiliation: Department of Chemistry, University of Munich (LMU), Butenandtstrasse 5-13, 81377, Munich, Germany.|Center for Integrated Protein Science (CIPSM) at the Department of Chemistry, University of Munich (LMU), Butenandtstrasse 5-13, 81377, Munich, Germany.
authors.forename: Christian
authors.initials: C
authors.lastname: Ochsenfeld
authors.affiliation: Department of New Materials and Biosystems, Max Planck Institute for Intelligent Systems, Stuttgart, 70569, Germany.|Department of Biophysical Chemistry, University of Heidelberg, Heidelberg, 69120, Germany.
authors.forename: Joachim P
authors.initials: JP
authors.lastname: Spatz
authors.affiliation: Max Planck Institute for Solid State Research, Heisenbergstrasse 1, 70569, Stuttgart, Germany. b.lotsch@fkf.mpg.de.|Department of Chemistry, University of Munich (LMU), Butenandtstrasse 5-13, 81377, Munich, Germany. b.lotsch@fkf.mpg.de.
authors.forename: Bettina V
authors.initials: BV
authors.lastname: Lotsch
mesh_terms: D004305:Dose-Response Relationship, Drug; D004337:Drug Carriers; D016503:Drug Delivery Systems; D065546:Drug Liberation; D007097:Imines; D000073396:Metal-Organic Frameworks / Q000737:chemistry*; D011108:Polymers; D016062:Porosity; D011794:Quercetin
chemical_list: D004337:Drug Carriers; D007097:Imines; D000073396:Metal-Organic Frameworks; D011108:Polymers; D011794:Quercetin
keywords: covalent organic frameworks; drug delivery; molecular dynamics; porous materials; supramolecular chemistry