title: Synthesis and Evaluation of 2'-Deoxy-2'-Spirodiflurocyclopropyl Nucleoside Analogs.
abstract: The preparation of 2'-deoxy-2'-siprodifluorocyclopropany-lnucleoside analogs has been achieved from α-d-glucose in several steps. The key step in the synthesis was the introduction of the difluorocyclopropane through a difluorocarbene type reaction at the 2'-position. Then, a series of novel 2'-deoxy-2'-spirodifluorocyclopropanyl nucleoside analogs were synthesized using the Vorbrüggen method. All the synthesized nucleosides were characterized and subsequently evaluated against hepatitis C and influenza A virus strains in vitro.
authors.affiliation: a Institute of Pharmaceutical Research , South China Normal University , Guangzhou , Guangdong , PR China.
authors.forename: Xiao
authors.initials: X
authors.lastname: Liu
authors.affiliation: a Institute of Pharmaceutical Research , South China Normal University , Guangzhou , Guangdong , PR China.
authors.forename: Xueliang
authors.initials: X
authors.lastname: Xia
authors.affiliation: a Institute of Pharmaceutical Research , South China Normal University , Guangzhou , Guangdong , PR China.
authors.forename: Chenghai
authors.initials: C
authors.lastname: Sun
authors.affiliation: b Guangzhou Institutes of Biomedicine and Heath , Chinese Academy of Sciences , Guangzhou , PR China.
authors.forename: Cai
authors.initials: C
authors.lastname: Lin
authors.affiliation: b Guangzhou Institutes of Biomedicine and Heath , Chinese Academy of Sciences , Guangzhou , PR China.
authors.forename: Yiqian
authors.initials: Y
authors.lastname: Zhou
authors.affiliation: b Guangzhou Institutes of Biomedicine and Heath , Chinese Academy of Sciences , Guangzhou , PR China.|c University of Chinese Academy of Sciences , Beijing , PR China.
authors.forename: Muzammal
authors.initials: M
authors.lastname: Hussain
authors.affiliation: b Guangzhou Institutes of Biomedicine and Heath , Chinese Academy of Sciences , Guangzhou , PR China.|c University of Chinese Academy of Sciences , Beijing , PR China.
authors.forename: Fei
authors.initials: F
authors.lastname: Tang
authors.affiliation: b Guangzhou Institutes of Biomedicine and Heath , Chinese Academy of Sciences , Guangzhou , PR China.|c University of Chinese Academy of Sciences , Beijing , PR China.
authors.forename: Lu
authors.initials: L
authors.lastname: Liu
authors.affiliation: a Institute of Pharmaceutical Research , South China Normal University , Guangzhou , Guangdong , PR China.
authors.forename: Xue
authors.initials: X
authors.lastname: Li
authors.affiliation: b Guangzhou Institutes of Biomedicine and Heath , Chinese Academy of Sciences , Guangzhou , PR China.|d State Key Laboratory of Respiratory Disease , Guangzhou Institutes of Biomedicine and Health , Guangzhou , PR China.
authors.forename: Jiancun
authors.initials: J
authors.lastname: Zhang
mesh_terms: D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D045744:Cell Line, Tumor; D004353:Drug Evaluation, Preclinical; D016174:Hepacivirus / Q000187:drug effects; D006801:Humans; D006845:Hydrocarbons, Fluorinated / Q000138:chemical synthesis / Q000494:pharmacology; D009980:Influenza A virus / Q000187:drug effects; D020128:Inhibitory Concentration 50; D009705:Nucleosides / Q000138:chemical synthesis* / Q000494:pharmacology; D013141:Spiro Compounds / Q000138:chemical synthesis* / Q000494:pharmacology
chemical_list: D000998:Antiviral Agents; D006845:Hydrocarbons, Fluorinated; D009705:Nucleosides; D013141:Spiro Compounds
keywords: 2′-deoxy-2′- spirodifluorocyclopropanyl nucleosides; hepatitis C; influenza A