title: Human health risk assessment of triclosan in land-applied biosolids.
abstract: Triclosan (5-chloro-2-[2,4-dichlorophenoxy]-phenol) is an antimicrobial agent found in a variety of pharmaceutical and personal care products. Numerous studies have examined the occurrence and environmental fate of triclosan in wastewater, biosolids, biosolids-amended soils, and plants and organisms exposed to biosolid-amended soils. Triclosan has a propensity to adhere to organic carbon in biosolids and biosolid-amended soils. Land application of biosolids containing triclosan has the potential to contribute to multiple direct and indirect human health exposure pathways. To estimate exposures and human health risks from biosolid-borne triclosan, a risk assessment was conducted in general accordance with the methodology incorporated into the US Environmental Protection Agency's Part 503 biosolids rule. Human health exposures to biosolid-borne triclosan were estimated on the basis of published empirical data or modeled using upper-end environmental partitioning estimates. Similarly, a range of published triclosan human health toxicity values was evaluated. Margins of safety were estimated for 10 direct and indirect exposure pathways, both individually and combined. The present risk assessment found large margins of safety (>1000 to >100 000) for potential exposures to all pathways, even under the most conservative exposure and toxicity assumptions considered. The human health exposures and risks from biosolid-borne triclosan are concluded to be de minimis. Environ Toxicol Chem 2016;35:2358-2367. © 2016 SETAC.
authors.affiliation: Gradient, Cambridge, Massachusetts, USA.
authors.forename: Tim
authors.initials: T
authors.lastname: Verslycke
authors.affiliation: Gradient, Seattle, Washington, USA.
authors.forename: David B
authors.initials: DB
authors.lastname: Mayfield
authors.affiliation: Gradient, Seattle, Washington, USA.
authors.forename: Jade A
authors.initials: JA
authors.lastname: Tabony
authors.affiliation: Colgate-Palmolive Company, Piscataway, New Jersey, USA.
authors.forename: Marie
authors.initials: M
authors.lastname: Capdevielle
authors.affiliation: Colgate-Palmolive Company, Piscataway, New Jersey, USA.
authors.forename: Brian
authors.initials: B
authors.lastname: Slezak
mesh_terms: D004781:Environmental Exposure / Q000009:adverse effects / Q000032:analysis; D006801:Humans; D008962:Models, Theoretical; D018570:Risk Assessment; D012987:Soil / Q000737:chemistry* / Q000592:standards; D012989:Soil Pollutants / Q000032:analysis* / Q000633:toxicity; D014260:Triclosan / Q000032:analysis* / Q000633:toxicity; D062065:Wastewater / Q000737:chemistry*
chemical_list: D012987:Soil; D012989:Soil Pollutants; D014260:Triclosan; D062065:Wastewater
keywords: Antimicrobials; Biosolids; Personal care products; Risk assessment; Triclosan