title: MRI-guided clinical 6-MV radiosensitization of glioma using a unique gadolinium-based nanoparticles injection.
abstract: OBJECTIVE
  This study reports the use of gadolinium-based AGuIX nanoparticles (NPs) as a theranostic tool for both image-guided radiation therapy and radiosensitization of brain tumors.
  
  
  METHODS
  Pharmacokinetics and regulatory toxicology investigations were performed on rodents. The AGuIX NPs' tumor accumulation was studied by MRI before 6-MV irradiation.
  
  
  RESULTS
  AGuIX NPs exhibited a great safety profile. A single intravenous administration enabled the tumor delineation by MRI with a T1 tumor contrast enhancement up to 24 h, and the tumor volume reduction when combined with a clinical 6-MV radiotherapy.
  
  
  CONCLUSIONS
  This study demonstrates the efficacy and the potential of AGuIX NPs for image-guided radiation therapy, promising properties that will be assessed in the upcoming Phase I clinical trial.
authors.affiliation: Department of Radiotherapy, Grenoble Alpes University Hospital, BP217, F38043 Grenoble, Cedex 9, France.|Grenoble Institute of Neurosciences, Grenoble Alpes University, F38000 Grenoble, France.|INSERM U1216, F38000 Grenoble, France.
authors.forename: Camille
authors.initials: C
authors.lastname: Verry
authors.affiliation: Nano-H SAS, F38070 Saint-Quentin-Fallavier, France.|Present affiliation: NH TherAguix, 43 boulevard du 11 novembre 1918, F69100 Villeurbanne, France.
authors.forename: Sandrine
authors.initials: S
authors.lastname: Dufort
authors.affiliation: Grenoble Institute of Neurosciences, Grenoble Alpes University, F38000 Grenoble, France.|INSERM U1216, F38000 Grenoble, France.
authors.forename: Emmanuel Luc
authors.initials: EL
authors.lastname: Barbier
authors.affiliation: Grenoble Institute of Neurosciences, Grenoble Alpes University, F38000 Grenoble, France.|INSERM U1216, F38000 Grenoble, France.
authors.forename: Olivier
authors.initials: O
authors.lastname: Montigon
authors.affiliation: Department of Pathology, Saint-Etienne University Hospital, F42055 Saint-Etienne, Cedex 2, France.
authors.forename: Michel
authors.initials: M
authors.lastname: Peoc'h
authors.affiliation: Department of Radiotherapy, Grenoble Alpes University Hospital, BP217, F38043 Grenoble, Cedex 9, France.
authors.forename: Philippe
authors.initials: P
authors.lastname: Chartier
authors.affiliation: Institute Light & Mater, UMR5306, Lyon1 University-CNRS, Lyon University, F69622 Villeurbanne, France.
authors.forename: François
authors.initials: F
authors.lastname: Lux
authors.affiliation: Department of Radiotherapy, Grenoble Alpes University Hospital, BP217, F38043 Grenoble, Cedex 9, France.
authors.forename: Jacques
authors.initials: J
authors.lastname: Balosso
authors.affiliation: Institute Light & Mater, UMR5306, Lyon1 University-CNRS, Lyon University, F69622 Villeurbanne, France.
authors.forename: Olivier
authors.initials: O
authors.lastname: Tillement
authors.affiliation: Institute Light & Mater, UMR5306, Lyon1 University-CNRS, Lyon University, F69622 Villeurbanne, France.
authors.forename: Lucie
authors.initials: L
authors.lastname: Sancey
authors.affiliation: Biomedical Beamline, European Synchrotron Radiation Facility, CS40220, F38043 Grenoble, Cedex 9, France.|Present affiliation: NH TherAguix, 43 boulevard du 11 novembre 1918, F69100 Villeurbanne, France.
authors.forename: Géraldine
authors.initials: G
authors.lastname: Le Duc
mesh_terms: D000818:Animals; D003287:Contrast Media / Q000008:administration & dosage / Q000737:chemistry; D004195:Disease Models, Animal; D005682:Gadolinium / Q000008:administration & dosage / Q000737:chemistry; D005910:Glioma / Q000000981:diagnostic imaging* / Q000473:pathology / Q000532:radiotherapy*; D006801:Humans; D008279:Magnetic Resonance Imaging; D053768:Metal Nanoparticles / Q000008:administration & dosage* / Q000737:chemistry; D011838:Radiation-Sensitizing Agents / Q000008:administration & dosage* / Q000737:chemistry; D051381:Rats
chemical_list: D003287:Contrast Media; D011838:Radiation-Sensitizing Agents; D005682:Gadolinium
keywords: MRI-guided radiation therapy; clinical 6-MV radiation therapy; radiosensitizing nanoparticles