title: Effects of two-year testosterone replacement therapy on cognition, emotions and quality of life in young and middle-aged hypogonadal men.
abstract: The aim of the study was to examine the effects of two-year testosterone replacement therapy on cognitive functioning, emotional state and quality of life in young and middle-aged men with hypogonadotropic hypogonadism. Nineteen males diagnosed with hypogonadotropic hypogonadism participated in the study. Cognitive functions were assessed by Trail Making Test and Digit Span Test of Wechsler Adult Intelligence Scale. Emotional state was evaluated by Profile of Mood States. Quality of life was evaluated by WHO Brief Quality of Life Questionnaire. Changes after two-year testosterone replacement therapy were detected in Trail Making A (42.9 ± 22.3 vs. 36.2 ± 22.5, p = .050) and B (90.6 ± 55.3 vs. 65.6 ± 21.4, p = .025) tests, showing improvement in attention and visual scanning abilities, executive function and psychomotor speed, as well as in Digit Span Test forward score (5.4 ± 2.0 vs. 6.1 ± 2.6, p = .046), showing improvement in attention capacity and psychomotor speed. No significant differences were observed in emotional state and quality of life. In conclusion, beneficial effect in cognitive functioning (improved attention and visual scanning ability, executive function and psychomotor speed), but not in emotional state and quality of life, was observed in young and middle-aged hypogonadal men after two-year testosterone replacement therapy.
authors.affiliation: Institute of Endocrinology, Lithuanian University of Health Sciences, Kaunas, Lithuania.
authors.forename: L
authors.initials: L
authors.lastname: Lašaitė
authors.affiliation: Institute of Endocrinology, Lithuanian University of Health Sciences, Kaunas, Lithuania.
authors.forename: J
authors.initials: J
authors.lastname: Čeponis
authors.affiliation: Institute of Endocrinology, Lithuanian University of Health Sciences, Kaunas, Lithuania.
authors.forename: R T
authors.initials: RT
authors.lastname: Preikša
authors.affiliation: Institute of Endocrinology, Lithuanian University of Health Sciences, Kaunas, Lithuania.
authors.forename: B
authors.initials: B
authors.lastname: Žilaitienė
mesh_terms: D000328:Adult; D000728:Androgens / Q000008:administration & dosage / Q000627:therapeutic use*; D001288:Attention / Q000187:drug effects; D003071:Cognition / Q000187:drug effects*; D015331:Cohort Studies; D004644:Emotions / Q000187:drug effects*; D056344:Executive Function / Q000187:drug effects; D020249:Hormone Replacement Therapy / Q000379:methods*; D006801:Humans; D007006:Hypogonadism / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D011788:Quality of Life; D011795:Surveys and Questionnaires; D013739:Testosterone / Q000008:administration & dosage / Q000627:therapeutic use*; D014145:Trail Making Test; D055815:Young Adult
chemical_list: D000728:Androgens; D013739:Testosterone
keywords: cognitive functioning; emotional state; quality of life; testosterone replacement therapy; young and middle-aged hypogonadal men