title: Antidepressant Action on Mitochondrial Dysfunction in Psychiatric Disorders.
abstract: Preclinical Research Mitochondria are cell organelles crucial to the production of cellular energy. Several lines of evidence have indicated that mitochondrial dysfunction could be related to the pathophysiology of CNS diseases including bipolar disorder, major depressive disorder, and schizophrenia. These changes include impaired energy metabolism in the brain, co-morbidity with mitochondrial diseases, the effects of psychotropics on mitochondrial function, increased mitochondrial DNA (mtDNA) deletion in the brain, and association with mtDNA polymorphisms. Additionally, psychotropic drug treatments can alter energy metabolism and may affect mitochondrial processes. This review focuses on recent findings regarding the effects of antidepressants on mitochondrial processes in psychiatric disorders. Drug Dev Res 77 : 400-406, 2016. © 2016 Wiley Periodicals, Inc.
authors.affiliation: Laboratory of Molecular Biology and Endocrinology, VINCA Institute of Nuclear Sciences, University of Belgrade, Serbia.
authors.forename: Miroslav
authors.initials: M
authors.lastname: Adzic
authors.affiliation: Laboratory of Molecular Biology and Endocrinology, VINCA Institute of Nuclear Sciences, University of Belgrade, Serbia.
authors.forename: Zeljka
authors.initials: Z
authors.lastname: Brkic
authors.affiliation: School of Medicine, University of Pristina, Kosovska Mitrovica, Serbia.
authors.forename: Sonja
authors.initials: S
authors.lastname: Bulajic
authors.affiliation: Laboratory of Molecular Biology and Endocrinology, VINCA Institute of Nuclear Sciences, University of Belgrade, Serbia.
authors.forename: Milos
authors.initials: M
authors.lastname: Mitic
authors.affiliation: Laboratory of Molecular Biology and Endocrinology, VINCA Institute of Nuclear Sciences, University of Belgrade, Serbia.
authors.forename: Marija B
authors.initials: MB
authors.lastname: Radojcic
mesh_terms: D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology / Q000627:therapeutic use*; D001921:Brain / Q000503:physiopathology; D004272:DNA, Mitochondrial; D004734:Energy Metabolism; D006801:Humans; D001523:Mental Disorders / Q000188:drug therapy* / Q000503:physiopathology; D028361:Mitochondrial Diseases / Q000188:drug therapy* / Q000503:physiopathology
chemical_list: D000928:Antidepressive Agents; D004272:DNA, Mitochondrial
keywords: antidepressants; brain energy metabolism; intracellular signaling; mitochondria; psychiatric disorders