title: Controlling molecularity and stability of hydrogen bonded G-quadruplexes by modulating the structure's periphery.
abstract: We report on self-assembly of guanosines with aromatic esters at their 5'-position. Depending on the basicity of the 5'-ester either discrete octamers G8·K(+)I(-) or hexadecamers G16·3K(+)3I(-) are formed. The thermodynamic and kinetic stabilities of the G-quadruplex can be controlled by interlayer hydrogen-bonding and by dispersion interactions on the assembly's periphery.
authors.affiliation: Department of Chemistry and Biochemistry, University of Maryland, College Park, MD 20742, USA. jdavis@umd.edu.
authors.forename: Keith B
authors.initials: KB
authors.lastname: Sutyak
authors.forename: Peter Y
authors.initials: PY
authors.lastname: Zavalij
authors.forename: Michael L
authors.initials: ML
authors.lastname: Robinson
authors.forename: Jeffery T
authors.initials: JT
authors.lastname: Davis