title: Properties of Achromobacter xylosoxidans highly resistant to aminoglycoside antibiotics.
abstract: We herein discovered a highly resistant clinical isolate of Pseudomonas aeruginosa with MICs to amikacin, gentamicin, and arbekacin of 128 μg/mL or higher in a drug sensitivity survey of 92 strains isolated from the specimens of Yoka hospital patients between January 2009 and October 2010, and Achromobacter xylosoxidans was separated from this P. aeruginosa isolate. The sensitivity of this bacterium to 29 antibiotics was investigated. The MICs of this A. xylosoxidans strain to 9 aminoglycoside antibiotics were: amikacin, gentamicin, arbekacin, streptomycin, kanamycin, neomycin, and spectinomycin, 1,024 μg/mL or ≥ 1,024 μg/mL; netilmicin, 512 μg/mL; and tobramycin, 256 μg/mL. This strain was also resistant to dibekacin. This aminoglycoside antibiotic resistant phenotype is very rare, and we are the first report the emergence of A. xylosoxidans with this characteristic.
authors.forename: Sachiko
authors.initials: S
authors.lastname: Nakamoto
authors.forename: Natsumi
authors.initials: N
authors.lastname: Goda
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Hayabuchi
authors.forename: Hiroo
authors.initials: H
authors.lastname: Tamaki
authors.forename: Ayami
authors.initials: A
authors.lastname: Ishida
authors.forename: Ayaka
authors.initials: A
authors.lastname: Suzuki
authors.forename: Kaori
authors.initials: K
authors.lastname: Nakano
authors.forename: Shoko
authors.initials: S
authors.lastname: Yui
authors.forename: Yuto
authors.initials: Y
authors.lastname: Katsumata
authors.forename: Yuki
authors.initials: Y
authors.lastname: Yamagami
authors.forename: Naoto
authors.initials: N
authors.lastname: Burioka
authors.forename: Hiroki
authors.initials: H
authors.lastname: Chikumi
authors.forename: Eiji
authors.initials: E
authors.lastname: Shimizu
mesh_terms: D042441:Achromobacter denitrificans / Q000187:drug effects*; D000617:Aminoglycosides / Q000494:pharmacology*; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D024881:Drug Resistance, Bacterial; D008826:Microbial Sensitivity Tests
chemical_list: D000617:Aminoglycosides; D000900:Anti-Bacterial Agents