title: Allosteric Modulation of Phosphatase Activity May Redefine Therapeutic Value.
abstract: Despite their extensive involvement in signaling pathways and disease pathologies, targeting protein phosphatases remains an underexplored opportunity in drug discovery. Selective intracellular regulation of phosphatases with small molecule inhibitors has been an unmet challenge. However, recent progress in the development of allosteric modulators encourages renewed efforts to exploit their potential as therapeutic targets.
authors.affiliation: Department of Chemistry, University of Pittsburgh , Pittsburgh, Pennsylvania 15260, United States.
authors.forename: Joseph M
authors.initials: JM
authors.lastname: Salamoun
authors.affiliation: Department of Chemistry, University of Pittsburgh , Pittsburgh, Pennsylvania 15260, United States.
authors.forename: Peter
authors.initials: P
authors.lastname: Wipf
mesh_terms: D000494:Allosteric Regulation; D055808:Drug Discovery; D006801:Humans; D010749:Phosphoprotein Phosphatases / Q000037:antagonists & inhibitors*
chemical_list: D010749:Phosphoprotein Phosphatases