title: [Serum Protein Expression Level in 47 Patients with Megaloblastic Anemia and Its Clinical Significance].
abstract: OBJECTIVE
  To study the clinical significance of serum protein expression level in patients with megaloblastic anemia(MA).
  
  
  METHODS
  A total of 47 patients with MA were enrolled in this study between November 2013 and November 2015, and 50 healthy people in the same period were selected as controls. The levels of total protein (TP), albumin (Alb), ferritin (FER), transferrin (TRF) and soluble transferrin receptor (sTfR) were compared between 2 groups, and the serum protein expression levels in different types of MA, varous anemia degrees of MA were analyzed.
  
  
  RESULTS
  The leves of TP, Alb and FER in MA patients were significantly lower than those in control group, the levels of TRF and sTfR were statistically significantly higher than those in control group(P<0.05); the levels of TP, Alb and FER in the patients with mild anemia were significantly higher than those in the patients with moderate and severe anemia, the levels of TRF and sTfR were statistically significantly lower(P<0.05), while the levels of TP, Alb and FER in patients with moderate anemia were significantly higher than those in the patients with severe anemia, the levels of TRF and sTfR were significantly lower(P<0.05). Compared with levels before treatment, the levels of TP, Alb and FER significantly increased after treatment, while the TRF and sTfR levels significantly decreased (P<0.05).
  
  
  CONCLUSIONS
  Serum levels of TP, Alb, FER, TRF and sTfR can provide a basis for the diagnosis of MA, and contribute to predict the disease to some extent.
authors.affiliation: Department of Hematology, Liupanshui Municipal People's Hospital, Liupanshui 553001, Guizhou Province, China.E-mail：15329783008@189.cn.
authors.forename: Yong
authors.initials: Y
authors.lastname: Ke
mesh_terms: D000749:Anemia, Megaloblastic; D005293:Ferritins; D006801:Humans; D011990:Receptors, Transferrin; D014168:Transferrin
chemical_list: D011990:Receptors, Transferrin; D014168:Transferrin; D005293:Ferritins