title: Effects of a multicomponent physical activity behavior change intervention on breast cancer survivor health status outcomes in a randomized controlled trial.
abstract: Little is known about the effects of physical activity behavior change interventions on health outcomes such as lower extremity dysfunction and SF-36 physical health (predictor of mortality) in breast cancer survivors. Furthermore, effect moderators are rarely reported. Therefore, we report the effects of the 3-month BEAT Cancer physical activity behavior change intervention on global health status and health indicators along with moderators of intervention outcomes. Postprimary treatment breast cancer survivors (n = 222) were randomized to BEAT Cancer or usual care (UC). SF-36, muscle strength, body mass index, lower extremity dysfunction (WOMAC), and life satisfaction were measured at 3 months (M3) and 6 months (M6). At M3, adjusted linear mixed-model analyses demonstrated statistically significant effects of BEAT Cancer versus UC on SF-36 physical health [mean between-group difference (M) = 2.1; 95 % confidence interval (CI) 0.3-3.9; p = 0.023], SF-36 mental health (M = 5.2; CI 2.8-7.6; p < 0.001), and all SF-36 subscores. Intervention benefits occurred for lower extremity physical dysfunction (M = -2.7; CI -5.0 to -0.5; p = 0.018), WOMAC total (M = -3.7; CI -6.7 to -0.6; p = 0.018), and life satisfaction (M = 2.4; CI 0.9-3.9; p = 0.001). Statistically significant effects persisted at M6 for mental health and vitality. Baseline value, income, marital status, cancer treatment, cancer stage, and months since diagnosis moderated one or more outcomes. BEAT Cancer improves SF-36, WOMAC, and life satisfaction outcomes with improvements in vitality and mental well-being continuing 3 months postintervention. Several moderators with potential to guide targeting individuals for optimal intervention benefit warrant further study.
authors.affiliation: Department of Nutrition Sciences, University of Alabama at Birmingham, 1720 2nd Avenue South, Birmingham, AL, 35294-3360, USA. rogersl@uab.edu.
authors.forename: Laura Q
authors.initials: LQ
authors.lastname: Rogers
authors.affiliation: Faculty of Physical Education and Recreation, University of Alberta, Edmonton, AB, Canada.
authors.forename: Kerry S
authors.initials: KS
authors.lastname: Courneya
authors.affiliation: Department of Nutrition Sciences, University of Alabama at Birmingham, 1720 2nd Avenue South, Birmingham, AL, 35294-3360, USA.
authors.forename: Stephen J
authors.initials: SJ
authors.lastname: Carter
authors.affiliation: Department of Kinesiology, Southern Illinois University Carbondale, Carbondale, IL, USA.
authors.forename: Philip M
authors.initials: PM
authors.lastname: Anton
authors.affiliation: Statistics and Research Informatics Core, Center for Clinical Research, Southern Illinois University School of Medicine, Springfield, IL, USA.
authors.forename: Steven
authors.initials: S
authors.lastname: Verhulst
authors.affiliation: Department of Psychiatry, Southern Illinois University School of Medicine, Springfield, IL, USA.
authors.forename: Sandra K
authors.initials: SK
authors.lastname: Vicari
authors.affiliation: Statistics and Research Informatics Core, Center for Clinical Research, Southern Illinois University School of Medicine, Springfield, IL, USA.
authors.forename: Randall S
authors.initials: RS
authors.lastname: Robbs
authors.affiliation: Department of Kinesiology and Community Health, University of Illinois at Urbana-Champaign, Urbana, IL, USA.
authors.forename: Edward
authors.initials: E
authors.lastname: McAuley
mesh_terms: D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000503:physiopathology / Q000523:psychology / Q000628:therapy*; D000073116:Cancer Survivors / Q000523:psychology*; D015444:Exercise / Q000502:physiology*; D005260:Female; D006304:Health Status; D006801:Humans; D008875:Middle Aged; D053580:Muscle Strength; D018482:Muscle, Skeletal / Q000502:physiology; D010349:Patient Compliance; D011788:Quality of Life / Q000523:psychology; D055815:Young Adult
keywords: Exercise; Oncology; Psychosocial; Survivorship; WOMAC