title: Significance of Cystatin C for Early Diagnosis of Contrast-Induced Nephropathy in Patients Undergoing Coronary Angiography.
abstract: BACKGROUND Contrast-induced nephropathy is acute kidney injury caused by contrast medium exposure. Serum creatinine is the clinical diagnostic standard, but it does not yield quick results. The serum level of cystatin C is stable and it can reflect renal function sensitively. The study aimed to assess the usefulness of cystatin C for early diagnosis of contrast-induced nephropathy in patients undergoing coronary angiography. MATERIAL AND METHODS We included 300 patients who underwent CAG. According to the sCr at 48 h, patients were divided into 2 groups: CIN group and non-CIN group. Their demographics and basal renal function were recorded. Changes in sCr, Cys C, and e GFR were compared at the same time. ROC analysis was used to assess the sensitivity and specificity of Cys C in the early diagnosis of CIN. RESULTS Comparison of basal renal function and serum level of Cys C showed no significant differences between the 2 groups. Serum level of Cys C increased significantly at 24 h (p<0.001), and sCr increased significantly at 48 h. ROC analysis showed that the AUC of the change in Cys C between baseline and 24 h was 0.936 (95% CI: 0.879-0.992, p=0.000) and the optimum cut-off level was 0.26 mg/L (sensitivity=89.7% and specificity=95.6%). CONCLUSIONS The concentration change of Cys C is better than sCr as a biomarker in the early detection of CIN.
authors.affiliation: Department of Cardiology, West China Hospital, School of Clinic Medicine, Sichuan University, Chengdu, Sichuan, China (mainland).
authors.forename: Mian
authors.initials: M
authors.lastname: Wang
authors.affiliation: Department of Cardiology, West China Hospital, School of Clinic Medicine, Sichuan University, Chengdu, Sichuan, China (mainland).
authors.forename: Li
authors.initials: L
authors.lastname: Zhang
authors.affiliation: Department of Nephrology, West China Hospital, School of Clinic Medicine, Sichuan University, Chengdu, Sichuan, China (mainland).
authors.forename: Rongzheng
authors.initials: R
authors.lastname: Yue
authors.affiliation: Department of Cardiology, West China Hospital, School of Clinic Medicine, Sichuan University, Chengdu, Sichuan, China (mainland).
authors.forename: Guiying
authors.initials: G
authors.lastname: You
authors.affiliation: Department of Cardiology, West China Hospital, School of Clinic Medicine, Sichuan University, Chengdu, Sichuan, China (mainland).
authors.forename: Rui
authors.initials: R
authors.lastname: Zeng
mesh_terms: D003287:Contrast Media / Q000009:adverse effects*; D017023:Coronary Angiography; D003404:Creatinine / Q000097:blood; D055316:Cystatin C / Q000097:blood*; D042241:Early Diagnosis; D005260:Female; D006801:Humans; D007674:Kidney Diseases / Q000097:blood / Q000139:chemically induced* / Q000175:diagnosis*; D008297:Male; D008875:Middle Aged; D012372:ROC Curve
chemical_list: D003287:Contrast Media; D055316:Cystatin C; D003404:Creatinine