title: Pancreatic metastasis of angiosarcoma (Stewart-Treves syndrome) diagnosed using endoscopic ultrasound-guided fine needle aspiration: A case report.
abstract: BACKGROUND
  Pancreatic involvement of angiosarcoma is extremely rare.
  
  
  METHODS
  We herein report a rare case of angiosarcoma associated with chronic lymphedema (Stewart-Treves syndrome) with pancreatic metastasis that was diagnosed using endoscopic ultrasound (EUS)/fine needle aspiration (FNA).
  
  
  RESULTS
  A 43-year-old woman with a history of radical hysterectomy with bilateral inguinal lymphadenectomy and chemoradiotherapy for cervical cancer 15 years prior noticed the presence of erythematous indurative plaques on her right femoral region, where chronic lymphedema had developed. Contrast-enhanced computed tomography (CT) revealed not only multiple nodules in the subcutaneous tissue of the right femoral region but also a 25 mm × 20 mm solid mass in the region of the pancreatic tail. A histological analysis of the specimens obtained using EUS/FNA revealed angiosarcoma that was immunohistochemically positive for platelet/endothelial cell adhesion molecule-1 but negative for cytokeratin. The patient was diagnosed as Stewart-Treves syndrome that had metastasized to the pancreas. Chemotherapy was performed, but the patient died 14 months after her diagnosis.
  
  
  CONCLUSIONS
  Unfortunately, this patient was not followed up, even though she had chronic lymphedema of the right femoral region due to the repeated occurrence of phlegmon. To improve the survival rate of this fatal secondary malignant complication of radical lymphadenectomy, an early diagnosis with consecutive and long-term clinical follow-up and close monitoring for Stewart-Treves syndrome is therefore important.
authors.affiliation: Division of Gastroenterology and Hematology/Oncology, Department of Medicine Department of Dermatology, Asahikawa Medical University, Hokkaido Gastroenterology Medicine Center, Shonan Kamakura General Hospital, Kanagawa Center for Clinical and Biomedical Research, Sapporo Higashi Tokushukai Hospital, Sapporo, Japan.
authors.forename: Junpei
authors.initials: J
authors.lastname: Sasajima
authors.forename: Jiro
authors.initials: J
authors.lastname: Uehara
authors.forename: Takuma
authors.initials: T
authors.lastname: Goto
authors.forename: Shugo
authors.initials: S
authors.lastname: Fujibayashi
authors.forename: Kazuya
authors.initials: K
authors.lastname: Koizumi
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Mizukami
authors.forename: Akemi
authors.initials: A
authors.lastname: Ishida-Yamamoto
authors.forename: Mikihiro
authors.initials: M
authors.lastname: Fujiya
authors.forename: Toshikatsu
authors.initials: T
authors.lastname: Okumura
mesh_terms: D000328:Adult; D061765:Endoscopic Ultrasound-Guided Fine Needle Aspiration; D005260:Female; D006394:Hemangiosarcoma / Q000175:diagnosis* / Q000473:pathology; D006801:Humans; D008204:Lymphangiosarcoma / Q000175:diagnosis* / Q000473:pathology; D010179:Pancreas / Q000000981:diagnostic imaging / Q000473:pathology; D010190:Pancreatic Neoplasms / Q000000981:diagnostic imaging / Q000556:secondary*; D014057:Tomography, X-Ray Computed