title: IgM Memory Cells: First Responders in Malaria.
abstract: Following the fate of antigen-specific memory B cells has been difficult. In this issue of Immunity, Krishnamurty et al. (2016) use a novel B cell tetramer to define Plasmodium-specific memory B cells in parasite-infected mice and demonstrate that after re-infection, somatically mutated IgM(+) memory B cells function as first responders by rapidly differentiating into T-cell-dependent plasmablasts and T-cell-independent plasma cells.
authors.affiliation: Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
authors.forename: Sara L
authors.initials: SL
authors.lastname: Stone
authors.affiliation: Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA. Electronic address: flund@uab.edu.
authors.forename: Frances E
authors.initials: FE
authors.lastname: Lund
mesh_terms: D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology; D007075:Immunoglobulin M; D007156:Immunologic Memory / Q000276:immunology*; D008288:Malaria / Q000276:immunology*; D051379:Mice; D013601:T-Lymphocytes / Q000276:immunology
chemical_list: D007075:Immunoglobulin M