title: Shedding Light on Metabotropic Glutamate Receptors.
abstract: In this issue of Cell Chemical Biology, the elegant manuscript by Rovira et al. (2016) describes a negative allosteric modulator (NAM) of mGlu4 metabotropic glutamate receptors with in vivo activity. This compound is rapidly and reversibly inactivated by light and represents a powerful pharmacological tool for the study of mGlu4 receptors in their native environment.
authors.affiliation: Department of Physiology and Pharmacology, University Sapienza of Rome, 00185 Rome, Italy; IRCCS Neuromed, 86077 Pozzilli, Italy. Electronic address: ferdinandonicoletti@hotmail.com.
authors.forename: Ferdinando
authors.initials: F
authors.lastname: Nicoletti
mesh_terms: D001391:Azo Compounds; D011761:Pyrrolidonecarboxylic Acid / Q000031:analogs & derivatives; D018094:Receptors, Metabotropic Glutamate
chemical_list: D001391:Azo Compounds; C000624706:OptoGluNAM4.1; D018094:Receptors, Metabotropic Glutamate; D011761:Pyrrolidonecarboxylic Acid