title: The bidirectional association between body weight and mobility disability: A population-based cohort.
abstract: Obesity is more common in people with mobility disability than in non-disabled individuals, but less is known about the longitudinal effects leading to this health state.
  
  
  
  To explore the potential bidirectional association between mobility disability and obesity.
  
  
  
  Participants were identified in the population-based Stockholm Public Health Cohort (2002-2010, n = 17 945). Observations with schizophrenia, depression, eating disorder, or cancer within 5 years during and prior to baseline were excluded. Mobility disability and height and weight to calculate BMI (kg/m(2)) were self-reported. We used multivariate-adjusted regression models to estimate relative risks (RRs) and 95% confidence intervals (CI) based on new cases of mobility disability in cohorts that were obese, overweight or normal weight at baseline, and increases in BMI over time by mobility disability status.
  
  
  
  Obesity at baseline was associated with incident mobility disability. The highest risk was observed in middle-aged women (RR = 3.95, CI = 2.35-6.65). Young men and middle-aged women with long-term mobility disability increased more in BMI (men: 1.55 kg/m(2), 0.61-2.49; women: 0.38, 0.01-0.75), as well as young and middle-aged people with incident mobility disability (young men: 0.68 kg/m(2), 0.10-1.27; middle-aged men: 0.49, 0.20-0.77; young women: 1.41, 0.94-1.87; middle-aged women: 0.64, 0.36-0.93) compared to the groups without any mobility disability.
  
  
  
  In this paper, we demonstrated the bidirectional and longitudinal associations between body weight and mobility disability and thus the increased risk of developing the combination over time from either condition. Effective health-promotion and prevention strategies are needed to prevent worse health for these vulnerable groups in society.
authors.affiliation: Child and Adolescent Public Health Epidemiology Research Group, Department of Public Health Sciences, Karolinska Institutet, Sweden. Electronic address: jeroen.de.munter@ki.se.
authors.forename: Jeroen S
authors.initials: JS
authors.lastname: de Munter
authors.affiliation: Child and Adolescent Public Health Epidemiology Research Group, Department of Public Health Sciences, Karolinska Institutet, Sweden.
authors.forename: Per
authors.initials: P
authors.lastname: Tynelius
authors.affiliation: The Swedish Institute for Health Sciences, Department of Health Sciences, Lund University, Sweden.
authors.forename: Gerd
authors.initials: G
authors.lastname: Ahlström
authors.affiliation: Child and Adolescent Public Health Epidemiology Research Group, Department of Public Health Sciences, Karolinska Institutet, Sweden.
authors.forename: Finn
authors.initials: F
authors.lastname: Rasmussen
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D015992:Body Mass Index; D001835:Body Weight; D006233:Persons with Disabilities; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D051346:Mobility Limitation; D009765:Obesity / Q000150:complications*; D050177:Overweight; D012307:Risk Factors; D057566:Self Report; D012737:Sex Factors
keywords: Disability; Observational cohort; Physical disability; Walking limitation; Weight gain