title: Low miR-29c expression is a prognostic marker in hepatocellular carcinoma.
abstract: A previous study has revealed that miR-29c functions as a tumor suppressor in hepatocellular carcinoma (HCC), but the clinical significance and prognostic value of miR-29c in HCC have not been investigated. Paired human HCC tissues and adjacent noncancerous tissues were obtained from 91 patients, between 2008 to 2014. Quantitative real-time PCR (qRT-PCR) was used to analyze miR-29c expression. Kaplan-Meier survival plots and log-rank tests were used to assess differences in the overall survival of different subgroups of HCC patients. It was observed that miR-29c expression was remarkably decreased in HCC tissues relative to that in normal hepatic tissues (P < 0.001). The low miR-29c level was significantly associated with histologic grade (P = 0.001), microvascular invasion (P = 0.005), and tumor stage (P < 0.001). Kaplan-Meier analysis showed that decreased miR-29c expression correlated with shorter overall survival (P = 0.002). Multivariate Cox regression analysis showed that decreased miR-29c expression (hazard ratio = 2.19, 95%CI = 1.361-6.779, P = 0.025) was independently associated with poor survival in HCC. Our findings demonstrate that miR-29c expression is significantly downregulated in HCC patients and that miR-29c can act as an independent predictor of unfavorable clinical outcome.
authors.affiliation: Department of General Surgery, Qilu Hospital, Shandong University, Jinan, Shandong, China.|Department of Hepatobiliary Surgery, Wei Fang People's Hospital, Wei Fang, Shandong, China.
authors.forename: C W
authors.initials: CW
authors.lastname: Dong
authors.affiliation: Department of Hepatobiliary Surgery, Wei Fang People's Hospital, Wei Fang, Shandong, China.
authors.forename: Y X
authors.initials: YX
authors.lastname: Wang
authors.affiliation: Department of Hepatobiliary Surgery, Wei Fang People's Hospital, Wei Fang, Shandong, China.
authors.forename: F T
authors.initials: FT
authors.lastname: Du
authors.affiliation: Department of Hepatobiliary Surgery, Wei Fang People's Hospital, Wei Fang, Shandong, China.
authors.forename: W
authors.initials: W
authors.lastname: Ding
authors.affiliation: Department of General Surgery, Qilu Hospital, Shandong University, Jinan, Shandong, China.
authors.forename: S Y
authors.initials: SY
authors.lastname: Hu
mesh_terms: D014408:Biomarkers, Tumor / Q000235:genetics* / Q000378:metabolism; D006528:Carcinoma, Hepatocellular / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D005260:Female; D006801:Humans; D008113:Liver Neoplasms / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D008297:Male; D035683:MicroRNAs / Q000235:genetics* / Q000378:metabolism; D008875:Middle Aged
chemical_list: D014408:Biomarkers, Tumor; C532045:MIRN29a microRNA, human; D035683:MicroRNAs