title: POSTNATAL SERUM INSULIN-LIKE GROWTH FACTOR I AND RETINOPATHY OF PREMATURITY.
abstract: OBJECTIVE
  Low serum IGF-1 has been associated with development of severe ROP, but no U.S. studies have been reported. We sought to determine the relationship between postnatal serum IGF-1 levels and severe ROP in a racially diverse U.S. cohort.
  
  
  METHODS
  Prospective cohort study of 74 infants with birth weight <1,251 g and a known ROP outcome at 3 Philadelphia hospitals. Weekly postnatal filter paper blood spot IGF-1 assays were measured through 42 weeks postmenstrual age.
  
  
  RESULTS
  The cohort included 20 white, 45 black, 2 Asian, and 9 other infants; median gestational age was 27.6 weeks (range 23-33 weeks), and median birth weight was 975 g (range 490-1,250 g). During postmenstrual age Weeks 28 to 33, mean IGF-1 was 20.0 ng/mL (standard error 0.52) for no ROP (n = 46), 18.0 (0.49) for Stage 1 or 2 (n = 23), and 17.0 (0.70) for Stage 3 (n = 5, 2 lasered) (P = 0.003). Adjustment for birth weight and gestational age showed similar results.
  
  
  CONCLUSIONS
  The presence and timing of an association between low postnatal serum IGF and ROP in a racially diverse U.S. sample were found to be consistent with those of European cohorts. This association provides the pathophysiological basis for growth-based predictive models, which could improve efficiency of ROP screening.
authors.affiliation: *Division of Ophthalmology, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania; and †Scheie Eye Institute, Department of Ophthalmology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.
authors.forename: Anne K
authors.initials: AK
authors.lastname: Jensen
authors.forename: Gui-Shuang
authors.initials: GS
authors.lastname: Ying
authors.forename: Jiayan
authors.initials: J
authors.lastname: Huang
authors.forename: Graham E
authors.initials: GE
authors.lastname: Quinn
authors.forename: Gil
authors.initials: G
authors.lastname: Binenbaum
mesh_terms: D015415:Biomarkers / Q000097:blood; D001724:Birth Weight; D005260:Female; D005865:Gestational Age; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007234:Infant, Premature; D007334:Insulin-Like Growth Factor I / Q000032:analysis*; D008297:Male; D011237:Predictive Value of Tests; D011446:Prospective Studies; D012178:Retinopathy of Prematurity / Q000097:blood*; D012307:Risk Factors; D014481:United States
chemical_list: D015415:Biomarkers; D007334:Insulin-Like Growth Factor I