title: Non-coding RNAs and disease: the classical ncRNAs make a comeback.
abstract: Many human diseases have been attributed to mutation in the protein coding regions of the human genome. The protein coding portion of the human genome, however, is very small compared with the non-coding portion of the genome. As such, there are a disproportionate number of diseases attributed to the coding compared with the non-coding portion of the genome. It is now clear that the non-coding portion of the genome produces many functional non-coding RNAs and these RNAs are slowly being linked to human diseases. Here we discuss examples where mutation in classical non-coding RNAs have been attributed to human disease and identify the future potential for the non-coding portion of the genome in disease biology.
authors.affiliation: Faculty of Life Sciences, The University of Manchester, Michael Smith Building, Oxford Road, Manchester M13 9PT, U.K.
authors.forename: Rogerio Alves
authors.initials: RA
authors.lastname: de Almeida
authors.affiliation: Faculty of Life Sciences, The University of Manchester, Michael Smith Building, Oxford Road, Manchester M13 9PT, U.K.
authors.forename: Marcin G
authors.initials: MG
authors.lastname: Fraczek
authors.affiliation: Faculty of Life Sciences, The University of Manchester, Michael Smith Building, Oxford Road, Manchester M13 9PT, U.K.
authors.forename: Steven
authors.initials: S
authors.lastname: Parker
authors.affiliation: Faculty of Life Sciences, The University of Manchester, Michael Smith Building, Oxford Road, Manchester M13 9PT, U.K.
authors.forename: Daniela
authors.initials: D
authors.lastname: Delneri
authors.affiliation: Faculty of Life Sciences, The University of Manchester, Michael Smith Building, Oxford Road, Manchester M13 9PT, U.K. rokeefe@manchester.ac.uk.
authors.forename: Raymond T
authors.initials: RT
authors.lastname: O'Keefe
mesh_terms: D004194:Disease / Q000235:genetics*; D015870:Gene Expression; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D015894:Genome, Human / Q000235:genetics*; D006801:Humans; D008957:Models, Genetic; D009154:Mutation; D012313:RNA / Q000235:genetics; D000077278:RNA, Mitochondrial; D022661:RNA, Untranslated / Q000235:genetics*
chemical_list: D000077278:RNA, Mitochondrial; D022661:RNA, Untranslated; D012313:RNA
keywords: RNase mitochondrial RNA processing (MRP); ncRNA; small nuclear RNA (snRNA); small nucleolar RNA (snoRNA); tRNA; telomerase RNA component (TERC)