title: New 2-(2-Phenylethyl)chromone Derivatives and Inhibitors of Phosphodiesterase (PDE) 3A from Agarwood.
abstract: The MeOH extract of agarwood showed inhibitory activity against phosphodiesterase (PDE) 3A. Fractionation of the extract led to the isolation of two new 2-(2-phenylethyl)chromones, 6,8-dihydroxy-2-[2-(4'-methoxyphenyl)ethyl]chromone (6), and 6,7-dihydroxy-2-(2-phenylethyl)chromone (8), together with six known compounds. All isolated compounds were tested for their PDE 3A inhibitory activity using fluorescence polarization method. Compound 7 showed PDE 3A inhibitory activity with IC50 of 4.83 μM.
authors.forename: Takuji
authors.initials: T
authors.lastname: Sugiyama
authors.forename: Yuji
authors.initials: Y
authors.lastname: Narukawa
authors.forename: Shunsuke
authors.initials: S
authors.lastname: Shibata
authors.forename: Ryo
authors.initials: R
authors.lastname: Masui
authors.forename: Fumiyuki
authors.initials: F
authors.lastname: Kiuchia
mesh_terms: D054684:Cyclic Nucleotide Phosphodiesterases, Type 3 / Q000737:chemistry*; D005419:Flavonoids / Q000737:chemistry* / Q000302:isolation & purification; D015394:Molecular Structure; D058987:Phosphodiesterase 3 Inhibitors / Q000737:chemistry*; D010936:Plant Extracts / Q000737:chemistry*; D029645:Thymelaeaceae / Q000737:chemistry*
chemical_list: D005419:Flavonoids; D058987:Phosphodiesterase 3 Inhibitors; D010936:Plant Extracts; C062550:2-(2-phenylethyl)chromone; D054684:Cyclic Nucleotide Phosphodiesterases, Type 3