title: Adenoid cystic carcinoma of submandibular gland metastatic to great toes: case report and literature review.
abstract: Adenoid cystic carcinoma (ACC) is a rare malignant tumor of the salivary glands, with higher frequency in the submandibular gland, a prolonged clinical course, and poor long-term survival. It tends to metastasize to lungs, bone, liver, brain, and rarely to skin. Comprehensive skin examination and appropriate follow-up is recommended, since cutaneous metastasis represents disease progression, requiring management and prognosis adjustment.
authors.affiliation: Pathology Department Northwell Health Laboratories Hofstra Northwell School of Medicine Lake Success New York USA.
authors.forename: Oana C
authors.initials: OC
authors.lastname: Rafael
authors.affiliation: Hematology Oncology Department Northwell Health Cancer Institute Monter Cancer Center Lake Success New York USA.
authors.forename: Doru
authors.initials: D
authors.lastname: Paul
authors.affiliation: Dermatopathology Pathology Department Hofstra Northwell School of Medicine Lake Success New York USA.
authors.forename: Sheng
authors.initials: S
authors.lastname: Chen
authors.affiliation: Head & Neck Surgical Oncology Northwell Health Lake Success New York USA.
authors.forename: Dennis
authors.initials: D
authors.lastname: Kraus
keywords: Adenoid cystic carcinoma; cutaneous metastases