title: Can rs3767140 SNP of the perlecan (HSPG2) gene affect the diabetes mellitus through the dyslipidemia?
abstract: Perlecan (HSPG2) play an important role in the lipoprotein metabolisms. The G allele of the HSPG2-rs3767140 may affect the binding of heparan sulfate (HS) chains and hence cause loss of HS from the basement membrane. HSPG2-rs3767140 was studied in 60 T2DM patients and 109 healthy controls. In diabetic patients HSPG2-rs3767140 T variant allele carriers (TT+GT) have decreased fasting plasma glucose (FPG) and serum LDL-C levels (p=0.071 and p=0.060, respectively) versus GG genotype carriers. Moreover, in both of the two groups in which the T allele carriers HDL-cholesterol levels tend to be high. We investigated that the HSPG2-rs3767140 promoted to the dyslipidemic phenotype in the type 2 diabetes mellitus (T2DM) patients. We suggest that the HSPG2-rs3767140 might be associated with the decreased FPG and LDL-C and with the increased HDL-C in diabetics. Therefore, the HSPG2-rs3767140 might be a protective for the diabetes mellitus due to its ameliorating effect on the dyslipidemic phenotype.
authors.affiliation: Halic University Department of Medical Biology, Faculty of Medicine Istanbul Turkey ozkurnaz@gmail.com.
authors.forename: Ö
authors.initials: Ö
authors.lastname: Kurnaz-Gömleksiz
authors.affiliation: Istanbul University Department of Molecular Medicine, Institute for Experimental Medicine Istanbul Turkey.
authors.forename: B
authors.initials: B
authors.lastname: Tokat
authors.affiliation: Istanbul University Department of Molecular Medicine, Institute for Experimental Medicine Istanbul Turkey.
authors.forename: E I
authors.initials: EI
authors.lastname: Aslan
authors.affiliation: Istanbul University Department of Molecular Medicine, Institute for Experimental Medicine Istanbul Turkey.
authors.forename: F
authors.initials: F
authors.lastname: Yanar
authors.affiliation: Haseki Training and Research Hospital Department of Internal Medicine Istanbul Turkey.
authors.forename: Z
authors.initials: Z
authors.lastname: Ermiş-Karaali
authors.affiliation: Istanbul University Department of Molecular Medicine, Institute for Experimental Medicine Istanbul Turkey.
authors.forename: O
authors.initials: O
authors.lastname: Öztürk
authors.affiliation: Istanbul University Department of Molecular Medicine, Institute for Experimental Medicine Istanbul Turkey.
authors.forename: H
authors.initials: H
authors.lastname: Yilmaz-Aydoğan
mesh_terms: D000483:Alleles; D016022:Case-Control Studies; D003710:Demography; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000150:complications* / Q000235:genetics*; D050171:Dyslipidemias / Q000097:blood / Q000150:complications* / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D019812:Heparan Sulfate Proteoglycans / Q000235:genetics*; D006801:Humans; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*
chemical_list: D019812:Heparan Sulfate Proteoglycans; D008055:Lipids; C071927:perlecan