title: The use of sugammadex in a pregnant patient with Wolff-Parkinson-White syndrome.
abstract: Wolff-Parkinson-White (WPW) syndrome is a rare pre-excitation syndrome which develops when atrioventricular conduction occurs through a pathologic accessory pathway known as the bundle of Kent instead of atrioventricular node, hence resulting in tachycardia. Patients with WPW syndrome may experience various symptoms arising from mild-to-moderate chest disease, palpitations, hypotension, and severe cardiopulmonary dysfunction. These patients are most often symptomatic because of cardiac arrhythmias. In this case report, we present an uneventful anesthetic management of a pregnant patient with WPW syndrome undergoing cesarean delivery. A 23-year-old American Society of Anesthesiologists class 2 pregnant patient was diagnosed with WPW syndrome. Her preoperative 12-lead electrocardiogram showed a sinus rhythm at 82 beats per minute, a delta wave, and a short PR interval. After an uneventful surgery, sugammadex 2mg/kg was administered as a reversal agent instead of neostigmine. Then she was discharged to her obstetrics service. Serious hemodynamic disorders may occur in patients with WPW syndrome due to development of fatal arrhythmias. Neostigmine used as a reversal agent in general anesthesia can trigger such fatal arrhythmias by leading changes in cardiac conduction. We believe that sugammadex, which is safely used in many areas in the scope of clinical practice, can be also used for patients diagnosed with WPW syndrome.
authors.affiliation: Department of Anesthesiology and Reanimation, Bilim University Medical Faculty, Istanbul, Turkey. Electronic address: turker.sengul@gmail.com.
authors.forename: Turker
authors.initials: T
authors.lastname: Sengul
authors.affiliation: Department of Anesthesiology and Reanimation, Bilim University Medical Faculty, Istanbul, Turkey.
authors.forename: Ayten
authors.initials: A
authors.lastname: Saracoglu
authors.affiliation: Department of Anesthesiology and Reanimation, Bilim University Medical Faculty, Istanbul, Turkey.
authors.forename: Sibel
authors.initials: S
authors.lastname: Sener
authors.affiliation: Department of Anesthesiology and Reanimation, Bilim University Medical Faculty, Istanbul, Turkey.
authors.forename: Olgac
authors.initials: O
authors.lastname: Bezen
mesh_terms: D000732:Androstanols / Q000037:antagonists & inhibitors; D000768:Anesthesia, General / Q000379:methods; D000773:Anesthesia, Obstetrical / Q000379:methods*; D002585:Cesarean Section / Q000379:methods*; D004562:Electrocardiography; D005260:Female; D006801:Humans; D009407:Nerve Block / Q000379:methods; D003473:Neuromuscular Nondepolarizing Agents / Q000037:antagonists & inhibitors; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular / Q000188:drug therapy / Q000503:physiopathology*; D000077123:Rocuronium; D000077122:Sugammadex; D014927:Wolff-Parkinson-White Syndrome / Q000188:drug therapy* / Q000503:physiopathology; D055815:Young Adult; D047408:gamma-Cyclodextrins / Q000627:therapeutic use*
chemical_list: D000732:Androstanols; D003473:Neuromuscular Nondepolarizing Agents; D047408:gamma-Cyclodextrins; D000077122:Sugammadex; D000077123:Rocuronium
keywords: Cesarean section; Sugammadex; Wolff Parkinson White