title: Resolvin D3 Is Dysregulated in Arthritis and Reduces Arthritic Inflammation.
abstract: Uncontrolled inflammation is a unifying component of many chronic inflammatory diseases, such as arthritis. Resolvins (Rvs) are a new family from the endogenous specialized proresolving mediators (SPMs) that actively stimulate resolution of inflammation. In this study, using lipid mediator metabololipidomics with murine joints we found a temporal regulation of endogenous SPMs during self-resolving inflammatory arthritis. The SPMs present in self-resolving arthritic joints include the D-series Rvs, for example, RvD1, RvD2, RvD3, and RvD4. Of note, RvD3 levels were reduced in inflamed joints from mice with delayed-resolving arthritis when compared with self-resolving inflammatory arthritis. RvD3 was also reduced in serum from rheumatoid arthritis patients compared with healthy controls. RvD3 administration reduced joint leukocytes as well as paw joint eicosanoids, clinical scores, and edema. Taken together, these findings provide evidence for dysregulated endogenous RvD3 levels in inflamed paw joints and its potent actions in reducing murine arthritis.
authors.affiliation: Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Harvard Institutes of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115; and.
authors.forename: Hildur H
authors.identifier: 0000-0002-5163-3946
authors.initials: HH
authors.lastname: Arnardottir
authors.affiliation: Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Harvard Institutes of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115; and.
authors.forename: Jesmond
authors.identifier: 0000-0001-6328-3640
authors.initials: J
authors.lastname: Dalli
authors.affiliation: William Harvey Research Institute, Barts and London School of Medicine, Queen Mary University of London, London EC1M 6BQ, United Kingdom.
authors.forename: Lucy V
authors.identifier: 0000-0001-5316-9115
authors.initials: LV
authors.lastname: Norling
authors.affiliation: Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Harvard Institutes of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115; and.
authors.forename: Romain A
authors.initials: RA
authors.lastname: Colas
authors.affiliation: William Harvey Research Institute, Barts and London School of Medicine, Queen Mary University of London, London EC1M 6BQ, United Kingdom.
authors.forename: Mauro
authors.identifier: 0000-0003-2068-3331
authors.initials: M
authors.lastname: Perretti
authors.affiliation: Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Harvard Institutes of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115; and cnserhan@zeus.bwh.harvard.edu.
authors.forename: Charles N
authors.identifier: 0000-0003-4627-8545
authors.initials: CN
authors.lastname: Serhan
mesh_terms: D000818:Animals; D001168:Arthritis / Q000276:immunology* / Q000378:metabolism* / Q000503:physiopathology; D004487:Edema / Q000517:prevention & control; D015777:Eicosanoids / Q000378:metabolism; D005231:Fatty Acids, Unsaturated / Q000008:administration & dosage / Q000097:blood / Q000378:metabolism*; D005786:Gene Expression Regulation; D006801:Humans; D007596:Joints / Q000276:immunology / Q000378:metabolism / Q000503:physiopathology; D050356:Lipid Metabolism; D055432:Metabolomics; D051379:Mice
chemical_list: D015777:Eicosanoids; D005231:Fatty Acids, Unsaturated; C583088:resolvin D3