title: Hair loss and regeneration performed on animal models.
abstract: Research in the field of reversal hair loss remains a challenging subject. As Minoxidil 2% or 5% and Finasteride are so far the only FDA approved topical treatments for inducing hair regrowth, research is necessary in order to improve therapeutical approach in alopecia. In vitro studies have focused on cultures of a cell type - dermal papilla or organ culture of isolated cell follicles. In vivo research on this topic was performed on mice, rats, hamsters, rabbits, sheep and monkeys, taking into consideration the advantages and disadvantages of each animal model and the depilation options. Further studies are required not only to compare the efficiency of different therapies but more importantly to establish their long term safety.
authors.affiliation: Department of Physiopathology, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania.
authors.forename: Meda Sandra
authors.initials: MS
authors.lastname: Orasan
authors.affiliation: Department of Physiology, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania.
authors.forename: Iulia Ioana
authors.initials: II
authors.lastname: Roman
authors.affiliation: Department of Histology, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania.
authors.forename: Andrei
authors.initials: A
authors.lastname: Coneac
authors.affiliation: Department of Physiology, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania.
authors.forename: Adriana
authors.initials: A
authors.lastname: Muresan
authors.affiliation: Department of Physiology, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania.
authors.forename: Remus Ioan
authors.initials: RI
authors.lastname: Orasan
keywords: alopecia; animal models; hair regrowth; research in vivo