title: Insufficient chunk concatenation may underlie changes in sleep-dependent consolidation of motor sequence learning in older adults.
abstract: Sleep enhances motor sequence learning (MSL) in young adults by concatenating subsequences ("chunks") formed during skill acquisition. To examine whether this process is reduced in aging, we assessed performance changes on the MSL task following overnight sleep or daytime wake in healthy young and older adults. Young adult performance enhancement was correlated with nREM2 sleep, and facilitated by preferential improvement of slowest within-sequence transitions. This effect was markedly reduced in older adults, and accompanied by diminished sigma power density (12-15 Hz) during nREM2 sleep, suggesting that diminished chunk concatenation following sleep may underlie reduced consolidation of MSL in older adults.
authors.affiliation: Department of Psychological and Brain Sciences, University of Massachusetts, Amherst, Massachusetts 01003, USA.
authors.forename: Ryan
authors.initials: R
authors.lastname: Bottary
authors.affiliation: Neuroscience and Behavior, University of Massachusetts, Amherst, Massachusetts 01003, USA.
authors.forename: Akshata
authors.initials: A
authors.lastname: Sonni
authors.affiliation: Department of Health and Kinesiology, Texas A&M University, College Station, Texas 77843, USA.
authors.forename: David
authors.initials: D
authors.lastname: Wright
authors.affiliation: Department of Psychological and Brain Sciences, University of Massachusetts, Amherst, Massachusetts 01003, USA Neuroscience and Behavior, University of Massachusetts, Amherst, Massachusetts 01003, USA rspencer@psych.umass.edu.
authors.forename: Rebecca M C
authors.initials: RM
authors.lastname: Spencer
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000375:Aging; D005260:Female; D006801:Humans; D007858:Learning / Q000502:physiology; D008297:Male; D000069077:Memory Consolidation / Q000502:physiology*; D008875:Middle Aged; D009048:Motor Skills; D011597:Psychomotor Performance; D012890:Sleep; D012894:Sleep Stages; D055815:Young Adult