title: Factors affecting sentinel lymph node metastasis in Turkish breast cancer patients: Predictive value of Ki-67 and the size of lymph node.
abstract: OBJECTIVE
  We aimed to analyze the factors that affect the axillary lymph node involvement in Turkish breast cancer patients with clinically non-palpable axillary lymph node.
  
  
  BACKGROUND
  Sentinel lymph node biopsy is the gold standard technique to evaluate the axillary lymph node status that directly influences the prognosis and the treatment options in breast cancer.
  
  
  METHODS
  Breast cancer patients without axillary lymph node involvement in clinic examination were enrolled the study. Patients were categorized into the two groups according to existence of axillary lymph node metastasis or not. Demographic, histopathological and clinical data of patients were revealed retrospectively.
  
  
  RESULTS
  One-hundred and eighty-seven patients were analyzed and 101 of patients fulfilled the criteria and were included the study. Metastatic lymph node was detected in 38 (37.6 %) patients (Group 1), and was negative in 63 (62.4 %) patients (Group 2). Sentinel lymph node metastasis were statistically significant higher in patients with Ki-67 ≥ 14 % than patients with Ki-67 < 14 % (51.9 % vs 22.4 %; p < 0.01). Likewise, the mean size of the sentinel lymph node was statistically significant higher in Group 1 compared to Group 2 (p < 0.01).
  
  
  CONCLUSIONS
  Ki-67 proliferation index and sentinel lymph node size may provide a higher prediction about the sentinel lymph node involvement in patients with clinically negative axillary lymph nodes (Tab. 3, Fig. 1, Ref. 31).
authors.forename: I A
authors.initials: IA
authors.lastname: Ozemir
authors.forename: K
authors.initials: K
authors.lastname: Orhun
authors.forename: T
authors.initials: T
authors.lastname: Eren
authors.forename: H
authors.initials: H
authors.lastname: Baysal
authors.forename: J
authors.initials: J
authors.lastname: Sagiroglu
authors.forename: M
authors.initials: M
authors.lastname: Leblebici
authors.forename: A B
authors.initials: AB
authors.lastname: Ceyran
authors.forename: O
authors.initials: O
authors.lastname: Alimoglu
mesh_terms: D000328:Adult; D000368:Aged; D001365:Axilla / Q000473:pathology; D014408:Biomarkers, Tumor / Q000032:analysis* / Q000378:metabolism; D001943:Breast Neoplasms / Q000175:diagnosis* / Q000473:pathology; D005260:Female; D006801:Humans; D019394:Ki-67 Antigen / Q000032:analysis* / Q000378:metabolism; D008198:Lymph Nodes / Q000473:pathology; D008207:Lymphatic Metastasis / Q000473:pathology*; D008875:Middle Aged; D008940:Mitotic Index; D011237:Predictive Value of Tests; D011379:Prognosis; D012189:Retrospective Studies; D000071036:Sentinel Lymph Node; D021701:Sentinel Lymph Node Biopsy / Q000379:methods*; D014421:Turkey
chemical_list: D014408:Biomarkers, Tumor; D019394:Ki-67 Antigen
keywords: Ki-67; breast cancer; lymph node size.; sentinel lymph node biopsy