title: Enantioselective Synthesis of Spirooxindole Enols: Regioselective and Asymmetric [3+2] Cyclization of 3-Isothiocyanato Oxindoles with Dibenzylidene Ketones.
abstract: A novel cinchona-alkaloid-derived organocatalyst has been developed to catalyze the asymmetric regioselective [3+2] cycloaddition of 3-isothiocyanato oxindoles with dibenzylidene ketones. A series of spirooxindole enols could be obtained in high yields with good-to-excellent diastereo- and enantioselectivities.
authors.affiliation: State Key Laboratory of Organometallic Chemistry Shanghai Institute of Organic Chemistry Chinese Academy of Sciences 345 Lingling Road Shanghai 200032 P. R. China.
authors.forename: Dan
authors.initials: D
authors.lastname: Du
authors.affiliation: Key Laboratory for Advanced Materials and Institute of Fine Chemicals East China University of Science and Technology Meilong Road No. 130 Shanghai 200237 P. R. China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Jiang
authors.affiliation: Key Laboratory for Advanced Materials and Institute of Fine Chemicals East China University of Science and Technology Meilong Road No. 130 Shanghai 200237 P. R. China.
authors.forename: Qin
authors.initials: Q
authors.lastname: Xu
authors.affiliation: State Key Laboratory of Organometallic Chemistry Shanghai Institute of Organic Chemistry Chinese Academy of Sciences 345 Lingling Road Shanghai 200032 P. R. China.
authors.forename: Xiao-Ge
authors.initials: XG
authors.lastname: Li
authors.affiliation: State Key Laboratory of Organometallic Chemistry Shanghai Institute of Organic Chemistry Chinese Academy of Sciences 345 Lingling Road Shanghai 200032 P. R. China; Key Laboratory for Advanced Materials and Institute of Fine Chemicals East China University of Science and Technology Meilong Road No. 130 Shanghai 200237 P. R. China.
authors.forename: Min
authors.initials: M
authors.lastname: Shi
keywords: [3+2] cyclization; asymmetric organocatalysis; regioselectivity; spirooxindole enols; stereoselectivity