title: The long non-coding RNA, SNHG6-003, functions as a competing endogenous RNA to promote the progression of hepatocellular carcinoma.
abstract: The expression of long non-coding RNAs (lncRNAs) is dysregulated in hepatocellular carcinoma (HCC). However, the functions and contributions of lncRNAs remain largely unknown. Here, we identified a critical role of SNHG6-003 in HCC. We found that five SNHG6 transcripts were differentially expressed in HCC tissues while only the SNHG6-003 had an oncogenic function. Ectopic expression of SNHG6-003 in HCC cells promoted cell proliferation and induced drug resistance, whereas SNHG6-003 knockdown promoted apoptosis. Moreover, SNHG6-003 functioned as a competitive endogenous RNA (ceRNA), effectively becoming sponge for miR-26a/b and thereby modulating the expression of transforming growth factor-β-activated kinase 1 (TAK1). Importantly, expression analysis revealed that both SNHG6-003 and TAK1 were upregulated in human cancers, exhibiting a co-expression pattern. In HCC patients, high expression of SNHG6-003 closely correlated with tumor progression and shorter survival. Thus, targeting the ceRNA network involving SNHG6-003 may be used as a treatment strategy against HCC.
authors.affiliation: Department of Radiation Oncology, Nanfang Hospital, Southern Medical University, Guangzhou, China.
authors.forename: C
authors.initials: C
authors.lastname: Cao
authors.affiliation: Guangdong Provincial Key Laboratory of Viral Hepatitis Research, Guangzhou, China.|Department of Infectious Diseases, Nanfang Hospital, Southern Medical University, Guangzhou, China.
authors.forename: T
authors.initials: T
authors.lastname: Zhang
authors.affiliation: Department of Radiation Oncology, Nanfang Hospital, Southern Medical University, Guangzhou, China.
authors.forename: D
authors.initials: D
authors.lastname: Zhang
authors.affiliation: Center for Molecular Medicine, University of Georgia, Athens, GA, USA.
authors.forename: L
authors.initials: L
authors.lastname: Xie
authors.affiliation: Guangdong Provincial Key Laboratory of Viral Hepatitis Research, Guangzhou, China.
authors.forename: X
authors.initials: X
authors.lastname: Zou
authors.affiliation: Department of Radiation Oncology, Nanfang Hospital, Southern Medical University, Guangzhou, China.
authors.forename: L
authors.initials: L
authors.lastname: Lei
authors.affiliation: Department of Radiation Oncology, Nanfang Hospital, Southern Medical University, Guangzhou, China.
authors.forename: D
authors.initials: D
authors.lastname: Wu
authors.affiliation: Guangdong Provincial Key Laboratory of Viral Hepatitis Research, Guangzhou, China.|Department of Infectious Diseases, Nanfang Hospital, Southern Medical University, Guangzhou, China.
authors.forename: L
authors.initials: L
authors.lastname: Liu
mesh_terms: D014408:Biomarkers, Tumor / Q000235:genetics*; D006528:Carcinoma, Hepatocellular / Q000235:genetics / Q000378:metabolism / Q000473:pathology*; D018450:Disease Progression; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008113:Liver Neoplasms / Q000235:genetics / Q000378:metabolism / Q000473:pathology*; D020930:MAP Kinase Kinase Kinases / Q000235:genetics / Q000378:metabolism*; D035683:MicroRNAs / Q000235:genetics; D009367:Neoplasm Staging; D011379:Prognosis; D062085:RNA, Long Noncoding / Q000235:genetics*; D012334:RNA, Neoplasm / Q000235:genetics*; D015398:Signal Transduction; D014407:Tumor Cells, Cultured; D000099151:MAP Kinase Kinase Kinase 7
chemical_list: D014408:Biomarkers, Tumor; D020930:MAP Kinase Kinase Kinases; D035683:MicroRNAs; D062085:RNA, Long Noncoding; D012334:RNA, Neoplasm; D000099151:MAP Kinase Kinase Kinase 7; C528163:MIRN26 microRNA, human