title: Cytomegalovirus colitis in a patient undergoing postoperative adjuvant chemotherapy for lung adenocarcinoma with uracil-tegafur.
abstract: When we examine a patient with symptoms of acute enteritis in the course of chemotherapy with oral fluoropyrimidines such as uracil-tegafur (often referred to as UFT), we usually suspect 5-fluorouracil-induced enterocolitis. In case of persistent clinical symptoms despite discontinuation of chemotherapy, cytomegalovirus colitis should be considered in the differential diagnosis of chemotherapy-induced enterocolitis. We herein report the case of a patient who underwent surgery for lung adenocarcinoma followed by postoperative adjuvant chemotherapy with uracil-tegafur and was diagnosed as having cytomegalovirus colitis during the therapy. In the course of chemotherapy, cytomegalovirus colitis occasionally occurs even though the patient does not experience severe myelosuppression; thus, it is necessary that we recognize its potential occurrence.
authors.affiliation: Department of Internal Medicine and Gastroenterology, Hokkaido P.W.F.A.C. Abashiri-Kosei General Hospital, Abashiri, Japan; Department of Gastroenterology and Hepatology, Hokkaido University Graduate School of Medicine, Sapporo, Japan. Electronic address: rock-hayashi-pop@rhythm.ocn.ne.jp.
authors.forename: Hideyuki
authors.initials: H
authors.lastname: Hayashi
authors.affiliation: Department of Cancer Chemotherapy, Hokkaido University Hospital Cancer Center, Sapporo, Japan.
authors.forename: Yoshito
authors.initials: Y
authors.lastname: Komatsu
authors.affiliation: Department of Internal Medicine and Gastroenterology, Hokkaido P.W.F.A.C. Abashiri-Kosei General Hospital, Abashiri, Japan.
authors.forename: Takumi
authors.initials: T
authors.lastname: Uchida
authors.affiliation: Department of Internal Medicine and Gastroenterology, Hokkaido P.W.F.A.C. Abashiri-Kosei General Hospital, Abashiri, Japan.
authors.forename: Nobuhiko
authors.initials: N
authors.lastname: Abe
authors.affiliation: Department of Internal Medicine and Gastroenterology, Hokkaido P.W.F.A.C. Abashiri-Kosei General Hospital, Abashiri, Japan.
authors.forename: Ken
authors.initials: K
authors.lastname: Ito
authors.affiliation: Department of Internal Medicine and Gastroenterology, Hokkaido P.W.F.A.C. Abashiri-Kosei General Hospital, Abashiri, Japan.
authors.forename: Kouji
authors.initials: K
authors.lastname: Hirata
authors.affiliation: Department of Internal Medicine and Gastroenterology, Hokkaido P.W.F.A.C. Abashiri-Kosei General Hospital, Abashiri, Japan.
authors.forename: Kana
authors.initials: K
authors.lastname: Matsuda
authors.affiliation: Department of Internal Medicine and Gastroenterology, Hokkaido P.W.F.A.C. Abashiri-Kosei General Hospital, Abashiri, Japan.
authors.forename: Akira
authors.initials: A
authors.lastname: Fujinaga
mesh_terms: D000230:Adenocarcinoma / Q000188:drug therapy*; D000077192:Adenocarcinoma of Lung; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D017024:Chemotherapy, Adjuvant / Q000379:methods; D003092:Colitis / Q000175:diagnosis* / Q000821:virology*; D003587:Cytomegalovirus / Q000302:isolation & purification*; D003586:Cytomegalovirus Infections / Q000175:diagnosis* / Q000821:virology; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy*; D011182:Postoperative Care; D005641:Tegafur / Q000008:administration & dosage
chemical_list: D005641:Tegafur; D005472:Fluorouracil
keywords: 5-Fluorouracil-induced enterocolitis; Adverse effect; Chemotherapy; Cytomegalovirus colitis; Lymphopenia; Uracil-tegafur