title: Macleaya cordata Extract Decreased Diarrhea Score and Enhanced Intestinal Barrier Function in Growing Piglets.
abstract: Macleaya cordata extract is of great scientific and practical interest to researchers, due to its antimicrobial and anti-inflammatory responses within experimental animals. This study was designed to determine the diarrhea score and innate immunity of growing piglets after they had received Macleaya cordata extract supplements. A total of 240 growing pigs were randomly assigned to one of three dietary treatments, with 8 replicates per treatment and 10 piglets per replicate. All pigs received a basal diet containing similar amounts of nutrients. The three treatments were a control (no additive), an antibiotic (200 mg/kg colistin), and the Macleaya cordata extract supplement group (40 mg/kg Macleaya cordata extract). The diarrhea score was calculated after D 28. The jejunal samples were obtained from five piglets selected randomly from each treatment on D 28. In comparison with the control group, the dietary Macleaya cordata extract and colistin group demonstrated a substantially decreased diarrhea score. The introduction of Macleaya cordata extract supplements to the diet significantly increased volumes of ZO-1 and claudin-1, particularly in comparison with the pigs in the control group (P < 0.05). The findings indicate that Macleaya cordata extract does enhance intestinal barrier function in growing piglets and that it could be used as a viable substitute for antibiotics.
authors.affiliation: Key Laboratory of Agro-Ecological Processes in Subtropical Region, Institute of Subtropical Agriculture, Chinese Academy of Sciences, Hunan Provincial Engineering Research Center of Healthy Livestock, Scientific Observing and Experimental Station of Animal Nutrition and Feed Science in South-Central China, Ministry of Agriculture, Hunan Co-Innovation Center of Animal Production Safety, Hunan 410125, China.
authors.forename: Gang
authors.identifier: 0000-0002-9475-5134
authors.initials: G
authors.lastname: Liu
authors.affiliation: College of Bioscience and Biotechnology, Hunan Agricultural University, Changsha, Hunan 410128, China.
authors.forename: Guiping
authors.identifier: 0000-0002-6850-9626
authors.initials: G
authors.lastname: Guan
authors.affiliation: College of Bioscience and Biotechnology, Hunan Agricultural University, Changsha, Hunan 410128, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Fang
authors.affiliation: Key Laboratory of Agro-Ecological Processes in Subtropical Region, Institute of Subtropical Agriculture, Chinese Academy of Sciences, Hunan Provincial Engineering Research Center of Healthy Livestock, Scientific Observing and Experimental Station of Animal Nutrition and Feed Science in South-Central China, Ministry of Agriculture, Hunan Co-Innovation Center of Animal Production Safety, Hunan 410125, China; Study Center of Animal Production, Faculty of Veterinary Medicine, University of Granma, Bayamo, Carretera Manzanillo 17 km, P.O. Box 21, 85100 Granma, Cuba.
authors.forename: Yordan
authors.initials: Y
authors.lastname: Martínez
authors.affiliation: Key Laboratory of Agro-Ecological Processes in Subtropical Region, Institute of Subtropical Agriculture, Chinese Academy of Sciences, Hunan Provincial Engineering Research Center of Healthy Livestock, Scientific Observing and Experimental Station of Animal Nutrition and Feed Science in South-Central China, Ministry of Agriculture, Hunan Co-Innovation Center of Animal Production Safety, Hunan 410125, China.
authors.forename: Shuai
authors.identifier: 0000-0002-9337-6191
authors.initials: S
authors.lastname: Chen
authors.affiliation: Key Laboratory of Agro-Ecological Processes in Subtropical Region, Institute of Subtropical Agriculture, Chinese Academy of Sciences, Hunan Provincial Engineering Research Center of Healthy Livestock, Scientific Observing and Experimental Station of Animal Nutrition and Feed Science in South-Central China, Ministry of Agriculture, Hunan Co-Innovation Center of Animal Production Safety, Hunan 410125, China.
authors.forename: Peng
authors.initials: P
authors.lastname: Bin
authors.affiliation: Department of Botany and Microbiology, Addiriyah Chair for Environmental Studies, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi Arabia.
authors.forename: Veeramuthu
authors.initials: V
authors.lastname: Duraipandiyan
authors.affiliation: Chongqing Medical and Pharmaceutical College, Shapingba, Chongqing 401331, China.
authors.forename: Ting
authors.identifier: 0000-0001-9595-4533
authors.initials: T
authors.lastname: Gong
authors.affiliation: Key Laboratory of Agro-Ecological Processes in Subtropical Region, Institute of Subtropical Agriculture, Chinese Academy of Sciences, Hunan Provincial Engineering Research Center of Healthy Livestock, Scientific Observing and Experimental Station of Animal Nutrition and Feed Science in South-Central China, Ministry of Agriculture, Hunan Co-Innovation Center of Animal Production Safety, Hunan 410125, China.
authors.forename: Myrlene Carine B
authors.identifier: 0000-0001-7321-2213
authors.initials: MC
authors.lastname: Tossou
authors.affiliation: Department of Botany and Microbiology, Addiriyah Chair for Environmental Studies, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi Arabia.
authors.forename: Naif Abdullah
authors.identifier: 0000-0002-2663-6328
authors.initials: NA
authors.lastname: Al-Dhabi
authors.affiliation: Key Laboratory of Agro-Ecological Processes in Subtropical Region, Institute of Subtropical Agriculture, Chinese Academy of Sciences, Hunan Provincial Engineering Research Center of Healthy Livestock, Scientific Observing and Experimental Station of Animal Nutrition and Feed Science in South-Central China, Ministry of Agriculture, Hunan Co-Innovation Center of Animal Production Safety, Hunan 410125, China.
authors.forename: Yulong
authors.initials: Y
authors.lastname: Yin
mesh_terms: D000818:Animals; D003967:Diarrhea / Q000188:drug therapy* / Q000503:physiopathology*; D004195:Disease Models, Animal; D007422:Intestines / Q000503:physiopathology*; D028101:Papaveraceae / Q000737:chemistry*; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D013552:Swine
chemical_list: D010936:Plant Extracts