title: DNA micelles as nanoreactors: efficient DNA functionalization with hydrophobic organic molecules.
abstract: We report a micelle-templated method to enhance the reactivity of DNA with highly hydrophobic molecules. Lipids, chromophores and polymers can be conjugated to DNA in high yield and under mild conditions. This method expands the range of DNA-templated reactions for DNA-encoded libraries, oligonucleotide and drug delivery, nanopore mimetics and DNA nanotechnology.
authors.affiliation: Department of Chemistry and Center for Self-Assembled Chemical Structures, McGill University, 801 Sherbrooke Street West, Montreal, Quebec, Canada H3A 0B8. hanadi.sleiman@mcgill.ca.
authors.forename: Tuan
authors.initials: T
authors.lastname: Trinh
authors.forename: Pongphak
authors.initials: P
authors.lastname: Chidchob
authors.forename: Hassan S
authors.initials: HS
authors.lastname: Bazzi
authors.forename: Hanadi F
authors.initials: HF
authors.lastname: Sleiman
mesh_terms: D004247:DNA / Q000138:chemical synthesis / Q000737:chemistry* / Q000378:metabolism; D004337:Drug Carriers / Q000138:chemical synthesis / Q000737:chemistry; D057927:Hydrophobic and Hydrophilic Interactions; D008055:Lipids / Q000737:chemistry; D008823:Micelles; D058608:Nanopores; D036103:Nanotechnology; D009841:Oligonucleotides / Q000138:chemical synthesis / Q000737:chemistry; D011108:Polymers / Q000737:chemistry; D013388:Succinimides / Q000737:chemistry
chemical_list: D004337:Drug Carriers; D008055:Lipids; D008823:Micelles; D009841:Oligonucleotides; D011108:Polymers; D013388:Succinimides; D004247:DNA; C001426:N-hydroxysuccinimide