title: [Comparative Cost Effectiveness of Clostridium Histolyticum Collagenase (Xiapex®) and Partial Fasciectomy for the Treatment of Dupuytren's Contracture in Austria].
abstract: BACKGROUND
  Since Dupuytren's contracture is a common disorder, the costs for its surgical treatment impose a considerable burden on the healthcare system. For the first time in the German-speaking area, this study aimed to provide a comparative cost-effectiveness analysis for partial fasciectomy vs. treatment with Clostridium histolyticum collagenase (CCH).
  
  
  METHODS
  A retrospective monocentric study of the period from 2012 to 2014 comprised 40 patients with previously untreated Dupuytren's contracture of one finger. 20 outpatients received one CCH treatment (Group 1), while 20 inpatients underwent partial fasciectomy (Group 2). The direct pre-interventional treatment and post-interventional costs were compared.
  
  
  RESULTS
  The direct post-interventional and postoperative results were comparable. Group 1 (CCH) showed a mean reduction in contracture of 96.4%; in Group 2 (partial fasciectomy), this was 97.7%. There were fewer complications in Group 1 than in Group 2. Mean treatment costs in Group 1 were € 1 458.60 and in Group 2, € 5 315.20.
  
  
  CONCLUSIONS
  Treatment with CCH is more cost effective than with partial fasciectomy. This is due to greater costs for personnel, time and surgical material, as well as the treatment of the more frequent complications in Group 2. Despite the limited comparability, our findings are consistent with the present international literature.
authors.affiliation: Abteilung für Plastische, Ästhetische und Rekonstruktive Chirurgie, Klinikum Klagenfurt am Wörthersee, Austria.
authors.forename: M
authors.initials: M
authors.lastname: Neuwirth
authors.affiliation: Abteilung für Plastische, Ästhetische und Rekonstruktive Chirurgie, Klinikum Klagenfurt am Wörthersee, Austria.
authors.forename: A
authors.initials: A
authors.lastname: Binter
authors.affiliation: Abteilung für Plastische, Ästhetische und Rekonstruktive Chirurgie, Klinikum Klagenfurt am Wörthersee, Austria.
authors.forename: W
authors.initials: W
authors.lastname: Pipam
authors.affiliation: Abteilung für Plastische, Ästhetische und Rekonstruktive Chirurgie, Klinikum Klagenfurt am Wörthersee, Austria.
authors.forename: M
authors.initials: M
authors.lastname: Rab
mesh_terms: D001317:Austria; D017364:Collagenases / Q000627:therapeutic use*; D003362:Cost-Benefit Analysis; D004387:Dupuytren Contracture / Q000628:therapy*; D000071938:Fasciotomy; D006801:Humans; D003012:Microbial Collagenase; D012189:Retrospective Studies
chemical_list: D017364:Collagenases; C570746:xiapex; D003012:Microbial Collagenase