title: Cobalt-Catalyzed, Aminoquinoline-Directed Functionalization of Phosphinic Amide sp2C-H Bonds.
abstract: In this paper, we introduce arylphosphinic acid aminoquinoline amides as competent substrates for cobalt-catalyzed sp2C-H bond functionalization. Specifically, the feasibility of their coupling with alkynes, alkenes, and allyl pivalate has been demonstrated. Reactions are catalyzed by simple Co(NO3)2hydrate in ethanol or mixed dioxane/tBuOH solvent in the presence of Mn(OAc)3·2H2O additive, sodium pivalate, or acetate base and use oxygen from the air as an oxidant. Directing group removal affords ortho-functionalizedP,P-diarylphosphinic acids.
authors.affiliation: Department of Chemistry, University of Houston, Houston, Texas 77204-5003, United States.
authors.forename: Tung Thanh
authors.initials: TT
authors.lastname: Nguyen
authors.affiliation: Department of Chemistry, University of Houston, Houston, Texas 77204-5003, United States.
authors.forename: Liene
authors.initials: L
authors.lastname: Grigorjeva
authors.affiliation: Department of Chemistry, University of Houston, Houston, Texas 77204-5003, United States.
authors.forename: Olafs
authors.initials: O
authors.lastname: Daugulis
keywords: C–H functionalization; alkenes; alkynes; cobalt; phosphinic amides