title: Preparation, Biological Evaluation and Dosimetry Studies of 175Yb-Bis-Phosphonates for Palliative Treatment of Bone Pain.
abstract: OBJECTIVE
  Optimized production and quality control of ytterbium-175 (Yb-175) labeled pamidronate and alendronate complexes as efficient agents for bone pain palliation has been presented.
  
  
  METHODS
  Yb-175 labeled pamidronate and alendronate (175Yb-PMD and 175Yb-ALN) complexes were prepared successfully at optimized conditions with acceptable radiochemical purity, stability and significant hydroxyapatite absorption. The biodistribution of complexes were evaluated up to 48 h, which demonstrated significant bone uptake ratios for 175Yb-PAM at all-time intervals. It was also detected that 175Yb-PAM mostly washed out and excreted through the kidneys.
  
  
  RESULTS
  The performance of 175Yb-PAM in an animal model was better or comparable to other 175Yb-bone seeking complexes previously reported.
  
  
  CONCLUSIONS
  Based on calculations, the total body dose for 175Yb-ALN is 40% higher as compared to 175Yb-PAM (especially kidneys) indicating that 175Yb-PAM is probably a safer agent than 175Yb-ALN.
authors.forename: Ashraf
authors.initials: A
authors.lastname: Fakhari
authors.affiliation: Nuclear Science and Technology Research Institute (NSTRI), Tehran, Iran Phone: +98-21-88221103 E-mail: ajalili@aeoi.org.ir.
authors.forename: Amir R
authors.initials: AR
authors.lastname: Jalilian
authors.forename: Hassan
authors.initials: H
authors.lastname: Yousefnia
authors.forename: Saeed
authors.initials: S
authors.lastname: Shanehsazzadeh
authors.forename: Ali Bahrami
authors.initials: AB
authors.lastname: Samani
authors.forename: Fariba Johari
authors.initials: FJ
authors.lastname: Daha
authors.forename: Mehdi Shafiee
authors.initials: MS
authors.lastname: Ardestani
authors.forename: Ali
authors.initials: A
authors.lastname: Khalaj