title: OMALIZUMAB RESCUED A ASTHMA-COPD OVERLAP SYNDROME PATIENT FROM A STATUS ASTHMATICS UNDER THE ICU MANAGEMENT.
abstract: An atopic asthmatic of 65-year-old man who was complicated with COPD and treated with inhaled corticosteroid, long-acting β2 agonist, long-acting muscarinic antagonist, and leukotriene receptor antagonist was hospitalized with a severe asthmatic attack. He was intubated and went onto an artificial respirator. He was gradually relieved by repeated intravenous administration of high-dose corticosteroid, and a respirator was switched over to non-invasive positive pressure ventilation on 24th day. However, he repeated asthmatic attacks which needed corticosteroid to recover. Omalizumab was administered on 35th day and asthmatic attacks remarkably decreased. He left the hospital on 71st day. It was thought that the additional administration of omalizumab provided a good clinical response for an intractable asthma.
authors.affiliation: Department of Respiratory Medicine, Tohoku University School of Medicine.
authors.forename: Shunichi
authors.initials: S
authors.lastname: Gamo
authors.forename: Hideya
authors.initials: H
authors.lastname: Iijima
authors.forename: Yumika
authors.initials: Y
authors.lastname: Seki
authors.forename: Ryo
authors.initials: R
authors.lastname: Horaguchi
authors.forename: Yuji
authors.initials: Y
authors.lastname: Suda
authors.forename: Yuriko
authors.initials: Y
authors.lastname: Shindoh
mesh_terms: D000368:Aged; D018927:Anti-Asthmatic Agents / Q000627:therapeutic use*; D001249:Asthma / Q000150:complications / Q000188:drug therapy* / Q000628:therapy; D006801:Humans; D007362:Intensive Care Units; D008297:Male; D000069444:Omalizumab / Q000627:therapeutic use*; D029424:Pulmonary Disease, Chronic Obstructive / Q000150:complications / Q000188:drug therapy* / Q000628:therapy
chemical_list: D018927:Anti-Asthmatic Agents; D000069444:Omalizumab