title: Screening for Lipid Disorders in Children and Adolescents: US Preventive Services Task Force Recommendation Statement.
abstract: OBJECTIVE
  Elevations in levels of total, low-density lipoprotein, and non-high-density lipoprotein cholesterol; lower levels of high-density lipoprotein cholesterol; and, to a lesser extent, elevated triglyceride levels are associated with risk of cardiovascular disease in adults.
  
  
  OBJECTIVE
  To update the 2007 US Preventive Services Task Force (USPSTF) recommendation on screening for lipid disorders in children, adolescents, and young adults.
  
  
  METHODS
  The USPSTF reviewed the evidence on screening for lipid disorders in children and adolescents 20 years or younger--1 review focused on screening for heterozygous familial hypercholesterolemia, and 1 review focused on screening for multifactorial dyslipidemia.
  
  
  RESULTS
  Evidence on the quantitative difference in diagnostic yield between universal and selective screening approaches, the effectiveness and harms of long-term treatment and the harms of screening, and the association between changes in intermediate outcomes and improvements in adult cardiovascular health outcomes are limited. Therefore, the USPSTF concludes that the balance of benefits and harms cannot be determined.
  
  
  CONCLUSIONS
  The USPSTF concludes that the current evidence is insufficient to assess the balance of benefits and harms of screening for lipid disorders in children and adolescents 20 years or younger. (I statement).
authors.affiliation: University of California, San Francisco.
authors.forename: Kirsten
authors.initials: K
authors.lastname: Bibbins-Domingo
authors.affiliation: Group Health Research Institute, Seattle, Washington.
authors.forename: David C
authors.initials: DC
authors.lastname: Grossman
authors.affiliation: University of Iowa, Iowa City.
authors.forename: Susan J
authors.initials: SJ
authors.lastname: Curry
authors.affiliation: Columbia University, New York, New York.
authors.forename: Karina W
authors.initials: KW
authors.lastname: Davidson
authors.affiliation: State University of New York Upstate Medical University, Syracuse.
authors.forename: John W
authors.initials: JW
authors.lastname: Epling
authors.affiliation: Pima County Department of Health, Tucson, Arizona.
authors.forename: Francisco A R
authors.initials: FA
authors.lastname: García
authors.affiliation: Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, Massachusetts.
authors.forename: Matthew W
authors.initials: MW
authors.lastname: Gillman
authors.affiliation: Duke University, Durham, North Carolina.
authors.forename: Alex R
authors.initials: AR
authors.lastname: Kemper
authors.affiliation: Fairfax Family Practice Residency, Fairfax, Virginia10Virginia Commonwealth University, Richmond.
authors.forename: Alex H
authors.initials: AH
authors.lastname: Krist
authors.affiliation: Yale University, New Haven, Connecticut.
authors.forename: Ann E
authors.initials: AE
authors.lastname: Kurth
authors.affiliation: University of Alabama at Birmingham.
authors.forename: C Seth
authors.initials: CS
authors.lastname: Landefeld
authors.affiliation: University of Missouri, Columbia.
authors.forename: Michael
authors.initials: M
authors.lastname: LeFevre
authors.affiliation: University of California, Los Angeles.
authors.forename: Carol M
authors.initials: CM
authors.lastname: Mangione
authors.affiliation: Veterans Affairs Palo Alto Health Care System, Palo Alto, California16Stanford University, Stanford, California.
authors.forename: Douglas K
authors.initials: DK
authors.lastname: Owens
authors.affiliation: University of Washington, Seattle.
authors.forename: William R
authors.initials: WR
authors.lastname: Phillips
authors.affiliation: Brown University, Providence, Rhode Island.
authors.forename: Maureen G
authors.initials: MG
authors.lastname: Phipps
authors.affiliation: University of Texas at Austin.
authors.forename: Michael P
authors.initials: MP
authors.lastname: Pignone
authors.affiliation: Mount Sinai School of Medicine, New York, New York21James J. Peters Veterans Affairs Medical Center, Bronx, New York.
authors.forename: Albert L
authors.initials: AL
authors.lastname: Siu
mesh_terms: D000293:Adolescent; D026683:Advisory Committees; D058070:Asymptomatic Diseases; D002318:Cardiovascular Diseases / Q000517:prevention & control; D002648:Child; D050171:Dyslipidemias / Q000175:diagnosis* / Q000209:etiology / Q000628:therapy; D006801:Humans; D006938:Hyperlipoproteinemia Type II / Q000175:diagnosis / Q000235:genetics / Q000628:therapy; D008055:Lipids / Q000097:blood; D008403:Mass Screening / Q000009:adverse effects / Q000379:methods*; D011314:Preventive Health Services; D018570:Risk Assessment; D014481:United States; D055815:Young Adult
chemical_list: D008055:Lipids