title: Effect of ghrelin on regulation of splenic sympathetic nerve discharge.
abstract: Ghrelin influences immune system function and modulates the sympathetic nervous system; however, the contribution of ghrelin to neural-immune interactions is not well-established because the effect of ghrelin on splenic sympathetic nerve discharge (SND) is not known. This study tested the hypothesis that central ghrelin administration would inhibit splenic SND in anesthetized rats. Rats received intracerebroventricular (ICV) injections of ghrelin (1nmol/kg) or aCSF. Lumbar SND recordings provided a non-visceral nerve control. The ICV ghrelin administration significantly increased splenic and lumbar SND, whereas mean arterial pressure (MAP) was not altered. These findings provide fundamental information regarding the nature of sympathetic-immune interactions.
authors.affiliation: Department of Anatomy and Physiology, Kansas State University, Manhattan, KS 66506, United States; Department of Biological Sciences, College of Science, University of Texas at El Paso, El Paso, TX 79968, United States.
authors.forename: Sivasai
authors.initials: S
authors.lastname: Balivada
authors.affiliation: Department of Anatomy and Physiology, Kansas State University, Manhattan, KS 66506, United States; Department of Biological Sciences, College of Science, University of Texas at El Paso, El Paso, TX 79968, United States. Electronic address: hnpawar@utep.edu.
authors.forename: Hitesh N
authors.initials: HN
authors.lastname: Pawar
authors.affiliation: Department of Anatomy and Physiology, Kansas State University, Manhattan, KS 66506, United States.
authors.forename: Shawnee
authors.initials: S
authors.lastname: Montgomery
authors.affiliation: Department of Anatomy and Physiology, Kansas State University, Manhattan, KS 66506, United States; Department of Biological Sciences, College of Science, University of Texas at El Paso, El Paso, TX 79968, United States.
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Kenney
mesh_terms: D000758:Anesthesia; D000818:Animals; D062186:Arterial Pressure / Q000187:drug effects / Q000502:physiology; D054439:Ghrelin / Q000494:pharmacology*; D006339:Heart Rate / Q000187:drug effects / Q000502:physiology; D007155:Immunologic Factors / Q000494:pharmacology; D007276:Injections, Intraventricular; D008159:Lumbar Vertebrae; D008297:Male; D017207:Rats, Sprague-Dawley; D013154:Spleen / Q000187:drug effects* / Q000294:innervation* / Q000502:physiology; D013564:Sympathetic Nervous System / Q000187:drug effects* / Q000502:physiology; D013566:Sympathomimetics / Q000494:pharmacology*
chemical_list: D054439:Ghrelin; D007155:Immunologic Factors; D013566:Sympathomimetics
keywords: Ghrelin; Intracerebroventricular injection; Lumbar SND; Splenic SND