title: Evolutionary dynamics of dengue virus populations within the mosquito vector.
abstract: To date, dengue virus evolution has mainly been addressed by studies conducted at the between-host level. Like other pathogens with high mutation rate and rapid replication, dengue viruses also evolve during the course of an infection. Over the last few years, the advent of deep-sequencing technologies has facilitated studies of dengue virus populations at the within-host level. Here, we review recent advances on the evolutionary dynamics of dengue virus populations within their mosquito vector. We discuss how identifying the evolutionary forces acting on dengue virus populations within the mosquito can shed light on the processes underlying vector-virus interactions and the evolution of epidemiologically relevant traits.
authors.affiliation: Insect-Virus Interactions Group, Department of Genomes and Genetics, Institut Pasteur, Paris, France; Centre National de la Recherche Scientifique, Unité de Recherche Associée 3012, Paris, France. Electronic address: louis.lambrechts@pasteur.fr.
authors.forename: Louis
authors.initials: L
authors.lastname: Lambrechts
authors.affiliation: Insect-Virus Interactions Group, Department of Genomes and Genetics, Institut Pasteur, Paris, France; Centre National de la Recherche Scientifique, Unité de Recherche Associée 3012, Paris, France; Université Pierre et Marie Curie, Cellule Pasteur UPMC, Paris, France.
authors.forename: Sebastian
authors.initials: S
authors.lastname: Lequime
mesh_terms: D000818:Animals; D005075:Biological Evolution; D003716:Dengue Virus / Q000145:classification / Q000235:genetics* / Q000254:growth & development*; D014644:Genetic Variation; D005828:Genetics, Population; D054884:Host-Pathogen Interactions; D000072138:Mosquito Vectors / Q000821:virology*; D011157:Population Dynamics