title: Hyaluronic acid covers in burn treatment: a systematic review.
abstract: OBJECTIVE
  To evaluate the effectiveness of hyaluronic acid in the healing of partial thickness burns.
  
  
  METHODS
  Systematic review of randomized controlled trials on the use of hyaluronic acid for the topical treatment of skin burns, based on recommendations of the Cochrane Handbook for Systematic Reviews of Interventions.
  
  
  RESULTS
  Two randomized controlled trials that analyzed 143 patients with partial thickness burns and/or deep partial thickness burns were selected. They compared the application of hyaluronic acid 0.2% associated to silver sulfadiazine 1% 5g/cm2 versus silver sulfadiazine 1% 5g/cm2 alone for the outcome of complete healing.
  
  
  CONCLUSIONS
  This review emphasizes the need for new well-designed randomized controlled trials to establish the therapeutic relevance of hyaluronic acid with respect to the healing of burns of partial thickness or deep partial thickness.
  
  
  OBJECTIVE
  Avaliar a efetividade do ácido hialurônico na cicatrização de queimaduras de espessura parcial.
  Revisão sistemática de ensaios clínicos randomizados sobre a utilização de ácido hialurônico no tratamento tópico de queimaduras de pele, baseada nas recomendações do Cochrane Handbook for Systematic Reviews of Interventions.
  
  
  RESULTS
  Foram recuperados dois ensaios clínicos randomizados que analisaram 143 pacientes portadores de queimaduras de espessura parcial e/ou espessura parcial profunda, comparando a aplicação de Ácido Hialurônico 0,2% associado à Sulfadiazina de Prata 1% 5g/cm2, versus Sulfadiazina de Prata 1% 5g/cm2 isolada, para o desfecho cicatrização completa.
  Esta revisão enfatiza a necessidade de novos ensaios clínicos randomizados bem delineados para estabelecimento da relevância terapêutica do ácido hialurônico no que tange à cicatrização de queimaduras de espessura parcial ou espessura parcial profunda.
authors.affiliation: Universidade Federal do Paraná, Postgraduate Program in Nursing, Curitiba, PR, Brazil.
authors.forename: Michel Marcos
authors.initials: MM
authors.lastname: Dalmedico
authors.affiliation: Universidade Federal do Paraná, Department of Nursing, Curitiba, PR, Brazil.
authors.forename: Marineli Joaquim
authors.initials: MJ
authors.lastname: Meier
authors.affiliation: Universidade Federal do Paraná, Department of Nursing, Curitiba, PR, Brazil.
authors.forename: Jorge Vinícius Cestari
authors.initials: JV
authors.lastname: Felix
authors.affiliation: Universidade Federal do Paraná, Postgraduate Program in Nursing, Curitiba, PR, Brazil.
authors.forename: Franciele Soares
authors.initials: FS
authors.lastname: Pott
authors.affiliation: Universidade Federal do Paraná, Postgraduate Program in Nursing, Curitiba, PR, Brazil.
authors.forename: Francislene de Fátima Cordeiro
authors.initials: Fde F
authors.lastname: Petz
authors.affiliation: Universidade Federal do Paraná, Postgraduate Program in Nursing, Curitiba, PR, Brazil.
authors.forename: Michelle Caroline
authors.initials: MC
authors.lastname: Santos
mesh_terms: D002056:Burns / Q000188:drug therapy*; D006801:Humans; D006820:Hyaluronic Acid / Q000627:therapeutic use*; D016032:Randomized Controlled Trials as Topic; D016896:Treatment Outcome; D014945:Wound Healing
chemical_list: D006820:Hyaluronic Acid