title: Direct access to 2-amino-5-azidomethylfurans through palladium-catalyzed azidative cycloisomerization of homoallenyl amides.
abstract: A room temperature, efficient, and palladium-catalyzed azidative cycloisomerization of homoallenyl amides using TMSN3 as the azidation reagent and PhI(O2CCF3)2 as the oxidant is described, producing a variety of 2-amino-5-azidomethylfurans in moderate to excellent yields. The products can be applied to the concise synthesis of 1,2,3-triazoles via a Cu-catalyzed azide-alkyne cycloaddition.
authors.affiliation: Department of Chemistry, Zhejiang Normal University, 688 Yingbin Road, Jinhua 321004, P. R. China. luofang19@zjnu.cn gangguo@zjnu.cn.
authors.forename: Qianwen
authors.initials: Q
authors.lastname: Huang
authors.forename: Hanliang
authors.initials: H
authors.lastname: Zheng
authors.forename: Shuiyou
authors.initials: S
authors.lastname: Liu
authors.forename: Lichun
authors.initials: L
authors.lastname: Kong
authors.forename: Fang
authors.initials: F
authors.lastname: Luo
authors.forename: Gangguo
authors.initials: G
authors.lastname: Zhu