title: Hemodynamic Correlates of Blood Pressure in Older Adults: The Atherosclerosis Risk in Communities (ARIC) Study.
abstract: The primary aim of the present study was to identify the hemodynamic correlates of both steady and pulsatile blood pressure (BP) in community-dwelling older adults. In 3762 adults aged 70 to 89 years, significant hemodynamic determinants of both brachial and carotid systolic BP included arterial stiffness as measured by aortic pulse wave velocity, stroke volume (via echocardiography), arterial wave reflection, left ventricular ejection time, and upstroke time. The strongest influence was exerted by arterial stiffness. The steady-state component of blood pressure, mean arterial pressure, was associated with both cardiac index and total peripheral resistance (TPR), but was more strongly associated with TPR. Results were similar when participants taking antihypertensive medications were excluded from analyses. The overall findings suggest that mean arterial pressure is associated strongly with TPR and that significant hemodynamic correlates of systolic BP included arterial stiffness, stroke volume, and arterial wave reflection.
authors.affiliation: University of Texas at Austin, Austin, TX.
authors.forename: Hirofumi
authors.initials: H
authors.lastname: Tanaka
authors.affiliation: University of North Carolina at Chapel Hill, Chapel Hill, NC.
authors.forename: Gerardo
authors.initials: G
authors.lastname: Heiss
authors.affiliation: Brigham and Women's Hospital, Harvard Medical School, Boston, MA.
authors.forename: Elizabeth L
authors.initials: EL
authors.lastname: McCabe
authors.affiliation: University of North Carolina at Chapel Hill, Chapel Hill, NC.
authors.forename: Michelle L
authors.initials: ML
authors.lastname: Meyer
authors.affiliation: Brigham and Women's Hospital, Harvard Medical School, Boston, MA.
authors.forename: Amil M
authors.initials: AM
authors.lastname: Shah
authors.affiliation: Brigham and Women's Hospital, Harvard Medical School, Boston, MA.
authors.forename: Judy R
authors.initials: JR
authors.lastname: Mangion
authors.affiliation: Brigham and Women's Hospital, Harvard Medical School, Boston, MA.
authors.forename: Justina
authors.initials: J
authors.lastname: Wu
authors.affiliation: Brigham and Women's Hospital, Harvard Medical School, Boston, MA.
authors.forename: Scott D
authors.initials: SD
authors.lastname: Solomon
authors.affiliation: Brigham and Women's Hospital, Harvard Medical School, Boston, MA.
authors.forename: Susan
authors.initials: S
authors.lastname: Cheng
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001794:Blood Pressure / Q000502:physiology*; D001916:Brachial Artery / Q000502:physiology*; D002339:Carotid Arteries / Q000502:physiology*; D005260:Female; D006439:Hemodynamics; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D013318:Stroke Volume; D014655:Vascular Resistance; D059289:Vascular Stiffness