title: A Guardian Angel Phosphatase for Mainline Carbon Metabolism.
abstract: It is increasingly clear that many metabolic enzymes mistakenly form minor but toxic side-products that must be eliminated to maintain normal fluxes. Collard et al. show that this is true of two iconic glycolytic enzymes, and that a hitherto somewhat mysterious phosphatase rescues central carbon metabolism from their mistakes.
authors.affiliation: Horticultural Sciences Department, University of Florida, Gainesville, FL 32611, USA.
authors.forename: Guillaume A
authors.initials: GA
authors.lastname: Beaudoin
authors.affiliation: Horticultural Sciences Department, University of Florida, Gainesville, FL 32611, USA. Electronic address: adha@ufl.edu.
authors.forename: Andrew D
authors.initials: AD
authors.lastname: Hanson
mesh_terms: D005635:Fructosediphosphates / Q000378:metabolism; D005942:Gluconates / Q000378:metabolism; D024601:Glyceraldehyde 3-Phosphate Dehydrogenase (NADP+) / Q000235:genetics / Q000378:metabolism*; D006019:Glycolysis / Q000187:drug effects; D006801:Humans; D006868:Hydrolysis; D007773:Lactates / Q000378:metabolism / Q000633:toxicity; D010744:Phosphoric Monoester Hydrolases / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism*; D011770:Pyruvate Kinase / Q000235:genetics / Q000378:metabolism*; D034741:RNA, Small Interfering / Q000235:genetics / Q000378:metabolism; D012441:Saccharomyces cerevisiae / Q000235:genetics / Q000378:metabolism*; D029701:Saccharomyces cerevisiae Proteins / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism*; D064210:Secondary Metabolism; D013400:Sugar Acids / Q000378:metabolism / Q000633:toxicity
chemical_list: C020462:4-phosphoerythronate; D005635:Fructosediphosphates; D005942:Gluconates; D007773:Lactates; D034741:RNA, Small Interfering; D029701:Saccharomyces cerevisiae Proteins; D013400:Sugar Acids; C048984:2-phospholactic acid; C027652:fructose 2,6-diphosphate; D024601:Glyceraldehyde 3-Phosphate Dehydrogenase (NADP+); D011770:Pyruvate Kinase; C000602301:Pho13 protein, S cerevisiae; C022408:phosphoglycolate phosphatase; D010744:Phosphoric Monoester Hydrolases; C008884:6-phosphogluconic acid
keywords: glycolysis; metabolite damage; metabolite repair; phosphatase; side-reaction