title: Survival Analysis of Implant in Patients With Diabetes Mellitus: A Systematic Review.
abstract: OBJECTIVE
  To determine the survival trend of dental implants after functional loading for ≥1 year in diabetic patients.
  
  
  METHODS
  An electronic search of the Cochrane Oral Health Group's Trials Register, Medline and Embase, plus a manual search up to December 2015 was performed. Studies assessing the survival rate of dental implants in patients with a diagnosis of diabetes mellitus were considered eligible. Screening of studies, quality assessment, and data extraction were conducted independently by 2 reviewers. Life-table analysis and Kaplan-Meier survival curves were used to evaluate implant survival and to plot the cumulative survival rate and cumulative hazard ratio.
  
  
  RESULTS
  Seven studies, including 1142 implants were identified. The cumulative survival rate was 0.96 ± 0.10 before loading, 0.93 ± 0.10 and 0.91 ± 0.10 at 1 year, and at the end of the follow-up period, respectively. The hazard ratio was 4% during the period of osseointegration, 3% during the first year of loading, and remained constant over the 6-year follow-up.
  
  
  CONCLUSIONS
  Patients with diabetes mellitus showed an increasing trend of implant failure during the period of osseointegration and the first year of loading.
authors.affiliation: *Associate Professor, Department of Oral and Maxillo-Facial Sciences, Sapienza University of Rome, Rome, Italy. †Postgraduate Student, Department of Oral and Maxillo-Facial Sciences, Sapienza University of Rome, Rome, Italy. ‡Assistant Professor, Department of Biotechnologies and Medical Surgical Sciences, Sapienza University of Rome, Rome, Italy. §Research Fellow, Department of Sense Organs, Sapienza University of Rome, Rome, Italy. ¶Full Professor, Department of Oral and Maxillo-Facial Sciences, Sapienza University of Rome, Rome, Italy.
authors.forename: Susanna
authors.initials: S
authors.lastname: Annibali
authors.forename: Nicola
authors.initials: N
authors.lastname: Pranno
authors.forename: Maria Paola
authors.initials: MP
authors.lastname: Cristalli
authors.forename: Gerardo
authors.initials: G
authors.lastname: La Monaca
authors.forename: Antonella
authors.initials: A
authors.lastname: Polimeni
mesh_terms: D015921:Dental Implants / Q000009:adverse effects*; D019232:Dental Restoration Failure / Q000706:statistics & numerical data*; D048909:Diabetes Complications / Q000453:epidemiology* / Q000209:etiology; D006801:Humans; D053208:Kaplan-Meier Estimate; D016348:Osseointegration
chemical_list: D015921:Dental Implants