title: Changes in Hematologic and Coagulation Profiles in Rabbits with Right-ventricle Pacing.
abstract: The aim of this study was to evaluate changes in hematology and coagulation in rabbits with right-ventricle pacing without medication.
  
  
  
  Blood was collected from ten non-anesthetized male rabbits from the jugular vein before and one month after pacemaker placement. Total erythrocyte, leukocyte and platelet count, hemoglobin, hematocrit and differential leukocyte count were done on automatic veterinary flow cytometry hematologic analyzer. Prothrombin time, activated partial thromboplastin time, fibrinogen level, D-dimers and kaolin-activated thromboelastography was measured from citrated blood.
  
  
  
  We found an increase in red blood cell mass and decrease in platelet count, while coagulation tests did not diff er between samplings.
  
  
  
  Right-ventricle pacing seems to have no influence on hemostasis in rabbits.
authors.affiliation: Department of Physiology, Faculty of Veterinary Medicine, University of Veterinary and Pharmaceutical Sciences, Brno, Czech
  Republic
authors.forename: Ivana
authors.initials: I
authors.lastname: Uhrikova
authors.affiliation: Department of Internal Medicine and Cardiology, University Hospital, Brno, Czech Republic
authors.forename: Milan
authors.initials: M
authors.lastname: Sepsi
authors.affiliation: Department of Human Pharmacology and Toxicology, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences,
  Brno, Czech Republic
authors.forename: Jana
authors.initials: J
authors.lastname: Hlozkova
authors.affiliation: Department of Human Pharmacology and Toxicology, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences,
  Brno, Czech Republic
authors.forename: Pavel
authors.initials: P
authors.lastname: Suchy
authors.affiliation: Department of Industrial Engineering, Faculty of Mechanical Engineering, University of Zilina, Zilina, Slovakia
authors.forename: Marta
authors.initials: M
authors.lastname: Kasajova
authors.affiliation: Department of Physiology, Faculty of Veterinary Medicine, University of Veterinary and Pharmaceutical Sciences, Brno, Czech
  Republic
authors.forename: Katerina
authors.initials: K
authors.lastname: Machackova
authors.affiliation: Department of Pharmacology and Clinical Pharmacology, Medical Faculty, Medical University of Plovdiv, Plovdiv, Bulgaria
authors.forename: Delian P
authors.initials: DP
authors.lastname: Delev
authors.affiliation: Department of Internal Medicine, Fondazione IRCCS Policlinico San Matteo, Università degli Studi di Pavia, Pavia, Italy
authors.forename: Rachele
authors.initials: R
authors.lastname: Ciccocioppo
authors.affiliation: Laboratory of Structural Biology and Proteomics, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences,
  Brno, Czech Republic|2nd Department of Surgery, Faculty of Medicine, Masaryk University, Brno, Czech Republic
authors.forename: Peter
authors.initials: P
authors.lastname: Kruzliak
authors.affiliation: Department of Human Pharmacology and Toxicology, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences,
  Brno, Czech Republic|Veterinary Clinic MaScHEER, Malesovice, Czech Republic
authors.forename: Peter
authors.initials: P
authors.lastname: Scheer
mesh_terms: D000818:Animals; D001772:Blood Cell Count; D001777:Blood Coagulation; D002304:Cardiac Pacing, Artificial; D004906:Erythrocyte Count; D005338:Fibrin Fibrinogen Degradation Products; D005340:Fibrinogen; D005434:Flow Cytometry; D006352:Heart Ventricles; D006400:Hematocrit; D006454:Hemoglobins; D006487:Hemostasis; D007958:Leukocyte Count; D008297:Male; D010138:Pacemaker, Artificial; D010314:Partial Thromboplastin Time; D010976:Platelet Count; D011517:Prothrombin Time; D011817:Rabbits; D013916:Thrombelastography
chemical_list: D005338:Fibrin Fibrinogen Degradation Products; D006454:Hemoglobins; C036309:fibrin fragment D; D005340:Fibrinogen