title: Mesenchymal stem cells provide prophylaxis against acute graft-versus-host disease following allogeneic hematopoietic stem cell transplantation: A meta-analysis of animal models.
abstract: A meta-analysis of animal models was conducted to evaluate the prophylactic effects of mesenchymal stem cells (MSCs) on acute graft-versus-host disease (aGVHD) after allogeneic hematopoietic stem cell transplantation. A total of 50 studies involving 1848 animals were included. The pooled results showed that MSCs significantly reduced aGVHD-associated mortality (risk ratio = 0.70, 95% confidence interval 0.62 to 0.79, P = 2.73×10-9) and clinical scores (standardized mean difference = -3.60, 95% confidence interval -4.43 to -2.76, P = 3.61×10-17). In addition, MSCs conferred robust favorable prophylactic effects on aGVHD across recipient species, MSC doses, and administration times, but not MSC sources. Our meta-analysis showed that MSCs significantly prevented mortality and alleviated the clinical manifestations of aGVHD in animal models. These data support further clinical trials aimed at evaluating the efficacy of using MSCs to prevent aGVHD.
authors.affiliation: Department of Hematology, Chinese People's Liberation Army (PLA) General Hospital, Beijing, China.|Department of Hematology and Oncology, Laoshan Branch, No. 401 Hospital of Chinese PLA, Qingdao, China.
authors.forename: Li
authors.initials: L
authors.lastname: Wang
authors.affiliation: Department of Hematology, Linyi People's Hospital, Linyi, China.
authors.forename: Haiyan
authors.initials: H
authors.lastname: Zhang
authors.affiliation: Department of Hematology, Chinese People's Liberation Army (PLA) General Hospital, Beijing, China.
authors.forename: Lixun
authors.initials: L
authors.lastname: Guan
authors.affiliation: Department of Hematology, Chinese People's Liberation Army (PLA) General Hospital, Beijing, China.
authors.forename: Shasha
authors.initials: S
authors.lastname: Zhao
authors.affiliation: Department of Hematology, Chinese People's Liberation Army (PLA) General Hospital, Beijing, China.
authors.forename: Zhenyang
authors.initials: Z
authors.lastname: Gu
authors.affiliation: Department of Hematology, Chinese People's Liberation Army (PLA) General Hospital, Beijing, China.
authors.forename: Huaping
authors.initials: H
authors.lastname: Wei
authors.affiliation: Department of Hematology, Chinese People's Liberation Army (PLA) General Hospital, Beijing, China.
authors.forename: Zhe
authors.initials: Z
authors.lastname: Gao
authors.affiliation: Department of Hematology, Chinese People's Liberation Army (PLA) General Hospital, Beijing, China.
authors.forename: Feiyan
authors.initials: F
authors.lastname: Wang
authors.affiliation: Department of Hematology, Chinese People's Liberation Army (PLA) General Hospital, Beijing, China.
authors.forename: Nan
authors.initials: N
authors.lastname: Yang
authors.affiliation: Department of Hematology, Chinese People's Liberation Army (PLA) General Hospital, Beijing, China.
authors.forename: Lan
authors.initials: L
authors.lastname: Luo
authors.affiliation: Department of Hematology, Chinese People's Liberation Army (PLA) General Hospital, Beijing, China.
authors.forename: Yonghui
authors.initials: Y
authors.lastname: Li
authors.affiliation: Department of Hematology, Chinese People's Liberation Army (PLA) General Hospital, Beijing, China.
authors.forename: Lili
authors.initials: L
authors.lastname: Wang
authors.affiliation: Department of Hematology, Chinese People's Liberation Army (PLA) General Hospital, Beijing, China.
authors.forename: Daihong
authors.initials: D
authors.lastname: Liu
authors.affiliation: Department of Hematology, Chinese People's Liberation Army (PLA) General Hospital, Beijing, China.
authors.forename: Chunji
authors.initials: C
authors.lastname: Gao
mesh_terms: D000818:Animals; D006086:Graft vs Host Disease / Q000517:prevention & control*; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D045164:Mesenchymal Stem Cell Transplantation; D059630:Mesenchymal Stem Cells / Q000166:cytology*; D051379:Mice; D023421:Models, Animal; D051381:Rats; D014184:Transplantation, Homologous
keywords: animal experimentation; graft-versus-host disease; hematopoietic stem cell transplantation; mesenchymal stem cells; meta-analysis