title: [Phosphate binders in renal patients: a point estimate from rationale, through evidences to the real world setting].
abstract: Phosphate binders represent a common intervention in renal patients affected by chronic kidney disease and mineral bone disorder (CKD-MBD). Although counteracting P overload through binders adoption is argued by a physiology-driven approach, the efficacy of this intervention on hard endpoints remains poorly evident. The inconsistencies between rationale and methodological weakness, concerning the clinical relevance of P binding in chronic kidney disease, will be herein discussed with special focus on the need of a multi-factorial treatment against CKD-MBD, which is currently more achievable due to the variety of P binders and the rapid evolution of nutritional therapy, dialysis techniques and nursing science.
authors.forename: Andrea
authors.initials: A
authors.lastname: Galassi
authors.forename: Maria Enrica
authors.initials: ME
authors.lastname: Giovenzana
authors.forename: Eleonora
authors.initials: E
authors.lastname: Galbiati
authors.forename: Sara
authors.initials: S
authors.lastname: Auricchio
authors.forename: Sara
authors.initials: S
authors.lastname: Colzani
authors.forename: Renzo
authors.initials: R
authors.lastname: Scanziani
mesh_terms: D002614:Chelating Agents / Q000627:therapeutic use*; D012080:Chronic Kidney Disease-Mineral and Bone Disorder / Q000150:complications / Q000188:drug therapy* / Q000503:physiopathology; D006801:Humans; D010710:Phosphates / Q000378:metabolism*; D017410:Practice Guidelines as Topic; D061205:Vascular Calcification / Q000188:drug therapy / Q000209:etiology
chemical_list: D002614:Chelating Agents; D010710:Phosphates