title: Laryngeal histoplasmosis.
abstract: Histoplasmosis is a fungal infection, having interesting synonyms such as Cave disease, Darling's disease, Ohio Valley disease, reticuloendotheliosis, Spelunker's lung and Caver's disease. The aetiological agent is a dimorphic fungus, Histoplasma capsulatum, causing chronic granulomatous disease. The route of transmission is by inhalation of dust particles from soil contaminated by excrement of birds or bats, harbouring the small spores or microconidia, which is considered the infectious form of fungus. The spectrum of illness ranges from subclinical infection of the lung to progressive disseminated disease. The major bulk of histoplasmosis infections are asymptomatic or present with mild influenza like illness and involve immunocompetent individuals. However, the immunocompromised or immunodeficient cases have disseminated/haematogenous infections with multiple organs involved and are usually fatal unless treated immediately. Laryngeal involvement is associated with the disseminated form of the disease. Histoplasmosis of larynx is a rare entity and poses diagnostic difficulty to otolaryngologists because clinically it may be mistaken for malignancy. We report an unusual case of laryngeal histoplasmosis in a man aged 60 years who presented with provisional diagnosis of tuberculosis/malignancy.
authors.affiliation: Department of Pathology, Jawaharlal Nehru Medical College, Aligarh, Uttar Pradesh, India.
authors.forename: Hina A
authors.initials: HA
authors.lastname: Ansari
authors.affiliation: Department of Pathology, Jawaharlal Nehru Medical College and Hospital, Aligarh, Uttar Pradesh, India.
authors.forename: Noora
authors.initials: N
authors.lastname: Saeed
authors.affiliation: Department of Pathology, Jawaharlal Nehru Medical College, Aligarh, Uttar Pradesh, India.
authors.forename: Nazoora
authors.initials: N
authors.lastname: Khan
authors.affiliation: Department of Pathology, Jawaharlal Nehru Medical College, Aligarh, Uttar Pradesh, India.
authors.forename: Naba
authors.initials: N
authors.lastname: Hasan
mesh_terms: D003937:Diagnosis, Differential; D006658:Histoplasma; D006660:Histoplasmosis / Q000175:diagnosis*; D006801:Humans; D007818:Laryngeal Diseases / Q000175:diagnosis*; D007822:Laryngeal Neoplasms / Q000175:diagnosis; D008297:Male; D008875:Middle Aged; D014387:Tuberculosis, Laryngeal / Q000175:diagnosis