title: Immunoprofile of the adenomatoid odontogenic tumor.
abstract: This study was focused on the immunohistochemical profile of the adenomatoid odontogenic tumor. A Pub/Medline search revealed a number of immunohistochemical studies including cytokeratin profiles, extracellular matrix proteins, Integrins, ameloblast-associated proteins resorption regulators (RANK, RANKL), p53, PCNA, MDM2 protein, cyclin D1, Ki-67, Bcl-2 metallothionein, metalloproteinases, D56 hepatocyte growth factor, c-met, DNA methyltransferase, podoplanin, TGF-βI, Smad-2/3, Smad-I-5/-8, Smad 4, beta- catenin, calretinin, and clonality. Careful interpretation of the findings indicates that the adenomatoid odontogenic tumor may be more of a hamartomatous than neoplastic nature.
authors.affiliation: Department of Oral Medicine, Dental Radiology and Oral Surgery, CC03, Charité-Universitaetsmedizin Berlin, Berlin, Germany.
authors.forename: P A
authors.initials: PA
authors.lastname: Reichart
authors.affiliation: Retired.
authors.forename: H P
authors.initials: HP
authors.lastname: Philipsen
authors.affiliation: Faculty of Dentistry, Center of Excellence for Dental Implantology, Chiang Mai University, Chiang Mai, Thailand.
authors.forename: P
authors.initials: P
authors.lastname: Khongkhunthian
authors.affiliation: The Milton J. Dance Head and Neck Center, The Greater Baltimore Medical Center, Baltimore, USA.
authors.forename: J J
authors.initials: JJ
authors.lastname: Sciubba
mesh_terms: D000564:Ameloblastoma / Q000378:metabolism*; D015254:DNA Modification Methylases / Q000378:metabolism; D016326:Extracellular Matrix Proteins / Q000378:metabolism; D006801:Humans; D007150:Immunohistochemistry; D036341:Intercellular Signaling Peptides and Proteins / Q000378:metabolism*; D007573:Jaw Neoplasms / Q000378:metabolism*; D007633:Keratins / Q000378:metabolism; D008565:Membrane Proteins / Q000378:metabolism*; D045726:Metalloproteases / Q000378:metabolism; D008668:Metallothionein / Q000378:metabolism; D009363:Neoplasm Proteins / Q000378:metabolism*; D009687:Nuclear Proteins / Q000378:metabolism*
chemical_list: D016326:Extracellular Matrix Proteins; D036341:Intercellular Signaling Peptides and Proteins; D008565:Membrane Proteins; D009363:Neoplasm Proteins; D009687:Nuclear Proteins; D007633:Keratins; D008668:Metallothionein; D015254:DNA Modification Methylases; D045726:Metalloproteases
keywords: adenomatoid odontogenic tumor; hamartoma; immunohistochemistry; neoplasm