title: The -2518 A/G polymorphism in the monocyte chemoattractant protein 1 gene (MCP-1) is associated with an increased risk of rheumatoid arthritis in Argentine patients.
abstract: The aim of this study was to analyze the influence of nucleotide transition (G/A) in position -2518 of the MCP-1 gene related to the susceptibility of developing RA. Two hundred twenty-three consecutive RA patients according to 2010 ACR/EULAR criteria were included; 120 healthy subjects were used as controls. MCP-1 -2518 A/G polymorphism (AG + GG) was present in 162 (72.6 %) RA patients and in 63 (52.5 %) healthy subjects [OR 2.44 (IC95% 1.53-3.88, p = 0.0002)]; associations for heterozygotes and homozygotes were OR 1.92 (IC95% 1.19-3.15, p = 0.001) and OR 5.19 (IC95% 2.34-11.51, p = 0.001), respectively. In Argentine patients, MCP-1 gene polymorphism confers susceptibility for developing RA.
authors.affiliation: Section of Rheumatology, Instituto de Rehabilitación Psicofísica, Echeverría 955, 1428, Buenos Aires, Argentina.
authors.forename: Emilia Saint
authors.initials: ES
authors.lastname: Martin
authors.affiliation: Section of Rheumatology, Instituto de Rehabilitación Psicofísica, Echeverría 955, 1428, Buenos Aires, Argentina.
authors.forename: Emilce E
authors.initials: EE
authors.lastname: Schneeberger
authors.affiliation: Hospital of Infectious Diseases F. J. Muñiz, Hemostasis and Thrombosis LaboratoryBuenos Aires, Buenos Aires, Argentina.
authors.forename: Federico M
authors.initials: FM
authors.lastname: Aranda
authors.affiliation: Hospital of Infectious Diseases F. J. Muñiz, Hemostasis and Thrombosis LaboratoryBuenos Aires, Buenos Aires, Argentina.
authors.forename: Silvia Wingeyer
authors.initials: SW
authors.lastname: Peres
authors.affiliation: Section of Rheumatology, Instituto de Rehabilitación Psicofísica, Echeverría 955, 1428, Buenos Aires, Argentina.
authors.forename: María
authors.initials: M
authors.lastname: Del Carmen Valerio
authors.affiliation: Section of Rheumatology, Instituto de Rehabilitación Psicofísica, Echeverría 955, 1428, Buenos Aires, Argentina.
authors.forename: Maria
authors.initials: M
authors.lastname: de Los Angeles Correa
authors.affiliation: Section of Rheumatology, Instituto de Rehabilitación Psicofísica, Echeverría 955, 1428, Buenos Aires, Argentina.
authors.forename: Fernando Dal
authors.initials: FD
authors.lastname: Pra
authors.affiliation: Internal Medicine Department, Hospital General de Agudos Juan A Fernández, Buenos Aires, Argentina.
authors.forename: Liliana
authors.initials: L
authors.lastname: Martinez
authors.affiliation: Internal Medicine Department, Hospital General de Agudos Juan A Fernández, Buenos Aires, Argentina.
authors.forename: Graciela
authors.initials: G
authors.lastname: Remondino
authors.affiliation: Hospital of Infectious Diseases F. J. Muñiz, Hemostasis and Thrombosis LaboratoryBuenos Aires, Buenos Aires, Argentina.
authors.forename: Gabriela
authors.initials: G
authors.lastname: de Larrañaga
authors.affiliation: Section of Rheumatology, Instituto de Rehabilitación Psicofísica, Echeverría 955, 1428, Buenos Aires, Argentina. gustavocitera@gmail.com.
authors.forename: Gustavo
authors.initials: G
authors.lastname: Citera
mesh_terms: D000483:Alleles; D001118:Argentina / Q000453:epidemiology; D001172:Arthritis, Rheumatoid / Q000453:epidemiology / Q000235:genetics*; D016022:Case-Control Studies; D018932:Chemokine CCL2 / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006579:Heterozygote; D006720:Homozygote; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic
chemical_list: C111835:CCL2 protein, human; D018932:Chemokine CCL2
keywords: Genetics; Methodology, rheumatoid arthritis (RA); Rheumatic diseases, immunology; Specialty fields, cytokines and inflammatory mediators; Tissues or models