title: The role of CCR5 in Chagas disease - a systematic review.
abstract: Chagas disease is an infection caused by the protozoan Trypanosoma cruzi. The clinical manifestations result from the chronic forms of the disease: indeterminate, cardiac, digestive or mixed. The pathogenesis of this disease is related to the genetic variability of both the parasite and the host with polymorphisms of genes involved in immune response possibly being involved in the variable clinical course. Cytokines play a key role in regulating immune response, in particular chemokines exert a crucial role in the control of leukocyte migration during the host's response to infectious processes. Furthermore, inflammatory cytokines and chemokines have been implicated in the generation of inflammatory infiltrates and tissue damage. The involvement of the CC Chemokine Receptor 5 (CCR5) in leukocyte migration to sites of inflammation has been elucidated and this receptor has been investigated in Chagas disease. Here we review the role of CCR5 in T. cruzi infection as well as its importance in the pathogenesis of the Chagas disease.
authors.affiliation: Laboratório de Imunogenética, Departamento de Biologia Molecular, Faculdade de Medicina de São José do Rio Preto, Avenida Brigadeiro Faria Lima, 5416, 15090-000 São José do Rio Preto, SP, Brazil.
authors.forename: Amanda P
authors.initials: AP
authors.lastname: de Oliveira
authors.affiliation: Laboratório de Imunogenética, Departamento de Biologia Molecular, Faculdade de Medicina de São José do Rio Preto, Avenida Brigadeiro Faria Lima, 5416, 15090-000 São José do Rio Preto, SP, Brazil.
authors.forename: Christiane M
authors.initials: CM
authors.lastname: Ayo
authors.affiliation: Departamento de Cardiologia e Cirurgia Cardiovascular, Faculdade de Medicina de São José do Rio Preto, Avenida Brigadeiro Faria Lima, 5416, 15090-000 São José do Rio Preto, SP, Brazil.
authors.forename: Reinaldo B
authors.initials: RB
authors.lastname: Bestetti
authors.affiliation: Laboratório de Imunogenética, Departamento de Biologia Molecular, Faculdade de Medicina de São José do Rio Preto, Avenida Brigadeiro Faria Lima, 5416, 15090-000 São José do Rio Preto, SP, Brazil.
authors.forename: Cinara C
authors.initials: CC
authors.lastname: Brandão de Mattos
authors.affiliation: Centro de Investigação de Microrganismos, Departamento de Doenças Dermatológicas, Infecciosas e Parasitárias, Faculdade de Medicina de São José do Rio Preto, Avenida Brigadeiro Faria Lima, 5416, 15090-000 São José do Rio Preto, SP, Brazil.
authors.forename: Carlos E
authors.initials: CE
authors.lastname: Cavasini
authors.affiliation: Laboratório de Imunogenética, Departamento de Biologia Molecular, Faculdade de Medicina de São José do Rio Preto, Avenida Brigadeiro Faria Lima, 5416, 15090-000 São José do Rio Preto, SP, Brazil. Electronic address: luiz.demattos@famerp.br.
authors.forename: Luiz C
authors.initials: LC
authors.lastname: de Mattos
mesh_terms: D014355:Chagas Disease / Q000235:genetics*; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006801:Humans; D011110:Polymorphism, Genetic / Q000235:genetics*; D019713:Receptors, CCR5 / Q000235:genetics*
chemical_list: D019713:Receptors, CCR5
keywords: CCR5; Chagas disease; Chemokine receptor; Chronic Chagas heart disease; Polymorphism