title: Altered regional homogeneity in patients with unilateral acute open-globe injury: a resting-state functional MRI study.
abstract: OBJECTIVE
  To investigate the underlying regional homogeneity (ReHo) brain activity changes in patients with unilateral acute open-globe injury (OGI) and their relationship with their clinical features.
  
  
  METHODS
  In total, 18 patients with acute OGI (16 males and two females) and 18 healthy controls (HCs; 16 males and two females) closely matched in age, sex, and education status participated in the study. Each subject underwent a resting-state functional magnetic resonance imaging scan. The ReHo method was used to assess local features of spontaneous brain activity. Receiver-operating characteristic curve was used to distinguish OGIs from HCs. The nonparametric statistical analysis was used to explore the relationship between the observed mean ReHo values of the different brain areas and the behavioral performance.
  
  
  RESULTS
  Compared with HCs, acute OGI patients had significantly increased ReHo values in the right cerebellum posterior lobe/lingual gyrus, left superior temporal gyrus/inferior frontal gyrus, left inferior frontal gyrus, left posterior cingulate cortex/precuneus, and left precentral operculum. However, there was no relationship between the observed mean ReHo values of the different brain areas and the behavioral performance.
  
  
  CONCLUSIONS
  Acute OGI may cause dysfunction in many brain regions, which may reflect the underlying pathologic mechanisms of acute vision loss in OGI patients.
authors.affiliation: Department of Ophthalmology, The First Affiliated Hospital of Nanchang University, Nanchang; Department of Ophthalmology, The First People's Hospital of Jiujiang City, Jiujiang.
authors.forename: Xin
authors.initials: X
authors.lastname: Huang
authors.affiliation: Department of Radiology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, People's Republic of China.
authors.forename: Hai-Jun
authors.initials: HJ
authors.lastname: Li
authors.affiliation: Department of Ophthalmology, The First Affiliated Hospital of Nanchang University, Nanchang.
authors.forename: Lei
authors.initials: L
authors.lastname: Ye
authors.affiliation: Department of Ophthalmology, The First Affiliated Hospital of Nanchang University, Nanchang.
authors.forename: Ying
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Department of Ophthalmology, The First Affiliated Hospital of Nanchang University, Nanchang.
authors.forename: Rong
authors.initials: R
authors.lastname: Wei
authors.affiliation: Department of Ophthalmology, The First Affiliated Hospital of Nanchang University, Nanchang.
authors.forename: Yu-Lin
authors.initials: YL
authors.lastname: Zhong
authors.affiliation: Department of Radiology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, People's Republic of China.
authors.forename: De-Chang
authors.initials: DC
authors.lastname: Peng
authors.affiliation: Department of Ophthalmology, The First Affiliated Hospital of Nanchang University, Nanchang.
authors.forename: Yi
authors.initials: Y
authors.lastname: Shao
keywords: ReHo; functional magnetic resonance imaging; open-globe injury; resting state