title: Myeloid-Derived Suppressor Cells in Cancers and Inflammatory Diseases: Angel or Demon?
abstract: Myeloid-derived suppressor cell (MDSC) is an important heterogeneous cell population that regulates innate and adaptive immune. The immunosuppressive potentiality is widely known. However, more and more data indicated that the heterogeneous cell population had immunostimulatory activities rather than immunosuppression in some microenvironments. Chronic inflammatory conditions contribute to accumulation of MDSCs. These pathologically activated cells played critical roles in cancer and inflammatory diseases. In this review, we mainly discuss the immunoregulation potentiality of MDSCs in cancer and inflammatory diseases.
authors.affiliation: Department of Immunology, Jiangsu University, Zhenjiang, China.|The Central Laboratory, The Fourth Affiliated Hospital of Jiangsu University, Zhenjiang, China.
authors.forename: Z
authors.initials: Z
authors.lastname: Su
authors.affiliation: Department of Immunology, Jiangsu University, Zhenjiang, China.|The Central Laboratory, The Fifth Affiliated Hospital of Nantong University, Taizhou, China.
authors.forename: P
authors.initials: P
authors.lastname: Ni
authors.affiliation: The Central Laboratory, The Fifth Affiliated Hospital of Nantong University, Taizhou, China.
authors.forename: C
authors.initials: C
authors.lastname: Zhou
authors.affiliation: Department of Immunology, Jiangsu University, Zhenjiang, China. szl30@sina.com.|The Central Laboratory, The Fourth Affiliated Hospital of Jiangsu University, Zhenjiang, China. szl30@sina.com.
authors.forename: J
authors.initials: J
authors.lastname: Wang
mesh_terms: D056704:Adaptive Immunity; D000818:Animals; D015703:Antigens, CD / Q000235:genetics / Q000276:immunology; D015415:Biomarkers / Q000378:metabolism; D002450:Cell Communication; D002454:Cell Differentiation; D049109:Cell Proliferation; D016207:Cytokines / Q000235:genetics / Q000276:immunology; D015870:Gene Expression; D000949:Histocompatibility Antigens Class II / Q000235:genetics / Q000276:immunology; D006801:Humans; D007113:Immunity, Innate; D056747:Immunomodulation; D007249:Inflammation / Q000235:genetics / Q000276:immunology* / Q000473:pathology; D051379:Mice; D000072737:Myeloid-Derived Suppressor Cells / Q000276:immunology* / Q000473:pathology; D009369:Neoplasms / Q000235:genetics / Q000276:immunology* / Q000473:pathology
chemical_list: D015703:Antigens, CD; D015415:Biomarkers; D016207:Cytokines; D000949:Histocompatibility Antigens Class II