title: Bioactive Thiazine and Benzothiazine Derivatives: Green Synthesis Methods and Their Medicinal Importance.
abstract: Thiazines are a group of heterocyclic organic compounds that are still largely unexplored for their pharmacological activities. There are different available methods for the synthesis of thiazine derivatives in the literature. In this review, we discuss available methods of thiazine preparation through green synthesis methods. Beside their synthesis, many thiazine derivatives are biologically active and play an important role in the treatment of various diseases and show promising results of varying degrees, where they act as antibacterial, antifungal, antitumor, antimalarial, antineoplastic, antiviral, anti-inflammatory, analgesic and anticancer agents and thus they represent an interesting class of heterocyclic medicinal compounds worthy of further exploration.
authors.affiliation: National Center of Excellence in Physical Chemistry, Peshawar University, Peshawar, Khyber Pukhtoonkhwa 25120, Pakistan. shahbiochemist@gmail.com.|Department of Biochemistry, Abdul Wali Khan University Mardan, Khyber Pukhtoonkhwa 25120, Pakistan. shahbiochemist@gmail.com.|Department of Chemistry, Islamia College University Peshawar, Peshawar, Khyber Pukhtoonkhwa 25120, Pakistan. shahbiochemist@gmail.com.
authors.forename: Syed Lal
authors.initials: SL
authors.lastname: Badshah
authors.affiliation: National Center of Excellence in Physical Chemistry, Peshawar University, Peshawar, Khyber Pukhtoonkhwa 25120, Pakistan. naeeem64@yahoo.com.
authors.forename: Abdul
authors.initials: A
authors.lastname: Naeem
mesh_terms: D000700:Analgesics / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D000893:Anti-Inflammatory Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D000935:Antifungal Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D000962:Antimalarials / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D000998:Antiviral Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D055772:Green Chemistry Technology; D006801:Humans; D015394:Molecular Structure; D013329:Structure-Activity Relationship; D013843:Thiazines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000700:Analgesics; D000900:Anti-Bacterial Agents; D000893:Anti-Inflammatory Agents; D000935:Antifungal Agents; D000962:Antimalarials; D000970:Antineoplastic Agents; D000998:Antiviral Agents; D013843:Thiazines
keywords: antibacterial activity; anticancer agents; biologically active; green synthesis; thiazine