title: Prospective 1-year follow-up pilot study of CT-guided microwave ablation in the treatment of bone and soft-tissue malignant tumours.
abstract: OBJECTIVE
  The aims of this work were to assess the feasibility, efficacy, short-term outcome and safety of microwave ablation (MWA) in the treatment of malignant musculoskeletal tumours.
  
  
  METHODS
  Sixteen bone and soft-tissue malignant tumours were prospectively included and were treated by CT-guided MWA. The percentage and size of necrosis of the lesions were measured by contrast-enhanced MRI before the procedure and after 1, 3, 6 and 12 months. mRECIST criteria were used to assess tumour response. Procedural success was defined as ≥80 % necrosis. Patient pain (as assessed using a numeric visual scale (NVS)) and side effects were noted.
  
  
  RESULTS
  Six osteolytic metastases, five osteoblastic metastases and five soft tissue sarcomas were treated. At 1 month, 40 % were treated completely, the percentage of necrosis was 85 ± 30.4 %, and the success rate was 80 %. At 3, 6 and 12 months the success rate was 80 %, 76.9 % and 63.6 %, respectively. At 12 months, four lesions (36.3 %) still had no recurrence. Mean NVS during the procedure was 3.5 ± 2.8. One patient had transitory sciatica without neurological deficit that was treated medically.
  
  
  CONCLUSIONS
  CT-guided MWA of bone and soft-tissue malignant tumours is efficient, well tolerated and has good short-term anti-cancer effects.
  
  
  CONCLUSIONS
  • CT-guided MWA is efficient in treating musculoskeletal malignant tumours. • This prospective pilot study showed MWA induces high percentages of tumour necrosis. • MWA has good short-term anti-cancer effects. • MWA has healing potential when lesions can be completely necrosed. • CT-guided MWA under equimolar mixture of oxygen-nitrous oxide inhalation is well tolerated.
authors.affiliation: Department of Musculoskeletal Imaging, University Hospital of Besancon, 25000, Besancon, France. radio.aubry@free.fr.|I4S laboratory, INSERM EA4268, University of Franche-Comte, 25000, Besancon, France. radio.aubry@free.fr.
authors.forename: Sébastien
authors.identifier: http://orcid.org/0000-0003-1724-5939
authors.initials: S
authors.lastname: Aubry
authors.affiliation: Department of Musculoskeletal Imaging, University Hospital of Besancon, 25000, Besancon, France.
authors.forename: Jonathan
authors.initials: J
authors.lastname: Dubut
authors.affiliation: Department of Musculoskeletal Imaging, University Hospital of Besancon, 25000, Besancon, France.
authors.forename: Jean-Philippe
authors.initials: JP
authors.lastname: Nueffer
authors.affiliation: Department of Oncology, University Hospital of Besancon, 25000, Besancon, France.
authors.forename: Loic
authors.initials: L
authors.lastname: Chaigneau
authors.affiliation: Clinical Investigation Center, INSERM CIT808, University Hospital of Besancon, 25000, Besancon, France.
authors.forename: Chrystelle
authors.initials: C
authors.lastname: Vidal
authors.affiliation: Department of Musculoskeletal Imaging, University Hospital of Besancon, 25000, Besancon, France.|I4S laboratory, INSERM EA4268, University of Franche-Comte, 25000, Besancon, France.
authors.forename: Bruno
authors.initials: B
authors.lastname: Kastler
mesh_terms: D055011:Ablation Techniques / Q000379:methods*; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001859:Bone Neoplasms / Q000000981:diagnostic imaging / Q000601:surgery*; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008872:Microwaves / Q000627:therapeutic use; D008875:Middle Aged; D010865:Pilot Projects; D011446:Prospective Studies; D015641:Radiography, Interventional / Q000379:methods*; D012983:Soft Tissue Neoplasms / Q000000981:diagnostic imaging / Q000601:surgery*; D014057:Tomography, X-Ray Computed / Q000379:methods*; D016896:Treatment Outcome; D055815:Young Adult
keywords: Bone metastasis; CT-guided; Microwave ablation; Soft tissue tumour; Thermoablative therapy