title: A Diagnostic Dilemma: Multiple Primary Intracranial Tumors Without Vestibular Schwannomas.
abstract: Sinonasal schwannomas with intracranial extension are exceedingly rare, with only 7 cases reported in the literature. Schwannomas can be isolated or multiple and are commonly associated with familial disorders such as neurofibromatosis 2 (NF 2) or familial schwannomatosis or in sporadic cases seen in sporadic schwannomatosis. Nearly all people with NF2 older than 30 years of age will have the hallmark of bilateral vestibular schwannomas (VS). This case highlights a reported case of an adult with separate primary intracranial tumors. We review the diagnostic criteria of NF2 and schwannomatosis, a recently described third variant of neurofibromatosis. In this case, we incorporate family history, histopathology, and the pathophysiology of both disorders to help determine a diagnosis for this patient.
authors.affiliation: University of Arizona College of Medicine, Department of Otolaryngology, Tucson, Arizona, USA eafaucett@oto.arizona.edu.
authors.forename: Erynne A
authors.initials: EA
authors.lastname: Faucett
authors.affiliation: University of Arizona College of Medicine, Department of Pathology, Tucson, Arizona, USA.
authors.forename: Brandon T
authors.initials: BT
authors.lastname: Larsen
authors.affiliation: University of Arizona College of Medicine, Department of Radiology, Tucson, Arizona, USA.
authors.forename: Rihan
authors.initials: R
authors.lastname: Khan
authors.affiliation: University of Arizona College of Medicine, Department of Otolaryngology, Tucson, Arizona, USA.
authors.forename: Alexander G
authors.initials: AG
authors.lastname: Chiu
authors.affiliation: University of Arizona College of Medicine, Department of Otolaryngology, Tucson, Arizona, USA.
authors.forename: Eugene H
authors.initials: EH
authors.lastname: Chang
mesh_terms: D001254:Astrocytoma / Q000000981:diagnostic imaging*; D001932:Brain Neoplasms / Q000000981:diagnostic imaging*; D005005:Ethmoid Sinus / Q000000981:diagnostic imaging; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008577:Meningeal Neoplasms / Q000000981:diagnostic imaging*; D008579:Meningioma / Q000000981:diagnostic imaging*; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary / Q000000981:diagnostic imaging*; D009442:Neurilemmoma / Q000175:diagnosis / Q000000981:diagnostic imaging* / Q000473:pathology; D017253:Neurofibromatoses / Q000175:diagnosis* / Q000473:pathology; D016518:Neurofibromatosis 2 / Q000175:diagnosis*; D009464:Neuroma, Acoustic; D010255:Paranasal Sinus Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology; D010296:Parietal Lobe / Q000000981:diagnostic imaging; D012878:Skin Neoplasms / Q000175:diagnosis* / Q000473:pathology
keywords: neurofibromatosis; schwannoma; schwannomatosis; sinonasal tumor