title: Myocardial perfusion and left ventricular function indices assessed by gated myocardial perfusion SPECT in methamphetamine abusers.
abstract: OBJECTIVE
  Methamphetamine (MA) is associated with alterations of cardiac structure and function, although it is less known. In this study, we assessed possible abnormality in myocardial perfusion and left ventricular function using gated myocardial perfusion SPECT.
  
  
  METHODS
  Fifteen patients with MA abuse, on the basis of Diagnostic and Statistical Manual of Mental Disorders, 4th ed. (DSM-IV) MA dependency determined by Structured Clinical Interview for DSM-IV, underwent 2-day dipyridamole stress/rest Tc-sestamibi gated myocardial perfusion SPECT.
  
  
  RESULTS
  An average daily dose of MA use was 0.91±1.1 (0.2-4) g. The duration of MA use was 3.4±2.1 (1-7) years. In visual and semiquantitative analyses, all patients had normal gated myocardial perfusion SPECT, with no perfusion defects. In all gated SPECT images, there was no abnormality in left ventricular wall motion and thickening. All summed stress scores and summed rest scores were below 3. Calculated left ventricular functional indices including the end-diastolic volume, end-systolic volume, and left ventricular ejection fraction were normal.
  
  
  CONCLUSIONS
  Many cardiac findings because of MA mentioned in previous reports are less likely because of significant epicardial coronary artery stenosis.
authors.affiliation: aDepartment of Medical Toxicology, Imam Reza Hospital bNuclear Medicine Research Center, Department of Nuclear Medicine, Ghaem Hospital, Mashhad University of Medical Sciences, Mashhad cDepartment of Radiology, Paramedical School, Shahid Behshti of Medical Sciences, Tehran, Iran.
authors.forename: Bita
authors.initials: B
authors.lastname: Dadpour
authors.forename: Vahid R
authors.initials: VR
authors.lastname: Dabbagh Kakhki
authors.forename: Reza
authors.initials: R
authors.lastname: Afshari
authors.forename: Masoumeh
authors.initials: M
authors.lastname: Dorri-Giv
authors.forename: Seyed A R
authors.initials: SA
authors.lastname: Mohajeri
authors.forename: Somayeh
authors.initials: S
authors.lastname: Ghahremani
mesh_terms: D000328:Adult; D019969:Amphetamine-Related Disorders / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D055426:Cardiac-Gated Single-Photon Emission Computer-Assisted Tomography / Q000379:methods*; D009202:Cardiomyopathies / Q000139:chemically induced / Q000000981:diagnostic imaging / Q000503:physiopathology; D006801:Humans; D008297:Male; D008694:Methamphetamine / Q000633:toxicity; D008875:Middle Aged; D055414:Myocardial Perfusion Imaging / Q000379:methods*; D016277:Ventricular Function, Left / Q000187:drug effects
chemical_list: D008694:Methamphetamine