title: A New Neolignan, and the Cytotoxic and Anti-HIV-1 Activities of Constituents from the Roots of Dasymaschalon sootepense.
abstract: Bioassay-guided isolation from the ethyl acetate extract of Dasymaschalon sootepense roots led to the isolation of twelve compounds including a new dihydrobenzo-furan neolignan, (+)-(2S,3S)-2,3-dihydro-2-(3,4-dimethoxyphenyl)-3-methylbenzofuran-5-carbaldehyde (5), and eleven known compounds (1-4, and 6-12). The chemical structures and stereochemistry of all the isolated compounds were established by spectroscopic techniques. The known compounds 4 and 6 have been fully characterized spectroscopically, including their absolute configurations. Cytotoxic and anti-HIV-1 reverse transcriptase (RT) activities of compounds 1-3, 5 and 8-12 were determined. Among compounds screened, compounds 2, 3 and 10 displayed weak cytotoxic activity with ED50 values ranging from 9.6-47.5 μM and only compound 2 was found weakly active against HIV-1 RT with an IC50 value of 323.2 μM.
authors.forename: Sakchai
authors.initials: S
authors.lastname: Hongthong
authors.forename: Chutima
authors.initials: C
authors.lastname: Kuhakarn
authors.forename: Thaworn
authors.initials: T
authors.lastname: Jaipetch
authors.forename: Pawinee
authors.initials: P
authors.lastname: Piyachaturawat
authors.forename: Surawat
authors.initials: S
authors.lastname: Jariyawat
authors.forename: Kanoknetr
authors.initials: K
authors.lastname: Suksen
authors.forename: Jitra
authors.initials: J
authors.lastname: Limthongkul
authors.forename: Narong
authors.initials: N
authors.lastname: Nuntasaen
authors.forename: Vichai
authors.initials: V
authors.lastname: Reutrakul
mesh_terms: D029061:Annonaceae / Q000737:chemistry*; D019380:Anti-HIV Agents / Q000737:chemistry / Q000494:pharmacology*; D015497:HIV-1 / Q000187:drug effects* / Q000502:physiology; D006801:Humans; D017705:Lignans / Q000737:chemistry / Q000494:pharmacology*; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D018517:Plant Roots / Q000737:chemistry
chemical_list: D019380:Anti-HIV Agents; D017705:Lignans; D010936:Plant Extracts