title: Isolation and Identification of Intermediates of the Oxidative Bilirubin Degradation.
abstract: Four endogenous products of oxidative bilirubin degradation were isolated and fully characterized. The constitutional isomers belong to the propentdyopents (PDPs). Their structures and further oxidative transformations to biologically active bilirubin oxidation end products (Z-BOXes) are reported. Using liquid chromatography-mass spectrometry protocols, PDPs were detected in human bile and gallstones. Given the recent interest in BOXes as effectors in cerebral vasospasms and liver dysfunction, co-occurring PDPs represent an additional potentially active compound class to be considered.
authors.affiliation: Institute of Inorganic and Analytical Chemistry, Friedrich Schiller University , Lessingstrasse 8, D-07743 Jena, Germany.
authors.forename: Marcel
authors.initials: M
authors.lastname: Ritter
authors.affiliation: Institute of Inorganic and Analytical Chemistry, Friedrich Schiller University , Lessingstrasse 8, D-07743 Jena, Germany.|Department of Anesthesiology and Intensive Care Medicine/Center for Sepsis Control and Care, Jena University Hospital , Erlanger Allee 101, D-07747 Jena, Germany.
authors.forename: Raphael A
authors.initials: RA
authors.lastname: Seidel
authors.affiliation: Institute of Inorganic and Analytical Chemistry, Friedrich Schiller University , Humboldtstrasse 8, D-07743 Jena, Germany.
authors.forename: Peter
authors.initials: P
authors.lastname: Bellstedt
authors.affiliation: Max Planck Institute for Chemical Ecology , Beutenberg Campus, Hans-Knöll-Str. 8, D-07745 Jena, Germany.
authors.forename: Bernd
authors.initials: B
authors.lastname: Schneider
authors.affiliation: Department of Anesthesiology and Intensive Care Medicine/Center for Sepsis Control and Care, Jena University Hospital , Erlanger Allee 101, D-07747 Jena, Germany.
authors.forename: Michael
authors.initials: M
authors.lastname: Bauer
authors.affiliation: Institute of Inorganic and Analytical Chemistry, Friedrich Schiller University , Humboldtstrasse 8, D-07743 Jena, Germany.
authors.forename: Helmar
authors.initials: H
authors.lastname: Görls
authors.affiliation: Institute of Inorganic and Analytical Chemistry, Friedrich Schiller University , Lessingstrasse 8, D-07743 Jena, Germany.|Max Planck Institute for Chemical Ecology , Beutenberg Campus, Hans-Knöll-Str. 8, D-07745 Jena, Germany.
authors.forename: Georg
authors.initials: G
authors.lastname: Pohnert
mesh_terms: D001663:Bilirubin / Q000737:chemistry / Q000302:isolation & purification* / Q000378:metabolism*; D002853:Chromatography, Liquid; D006801:Humans; D013058:Mass Spectrometry; D015394:Molecular Structure; D010084:Oxidation-Reduction
chemical_list: D001663:Bilirubin