title: Synthesis and Antimicrobial Activity of Some New Thiadiazoles, Thioamides, 5-Arylazothiazoles and Pyrimido[4,5-d][1,2,4]triazolo[4,3-a]pyrimidines.
abstract: A novel series of 1,3,4-thiadiazoles, 5-arylazothiazoles and hexahydropyrimido-[4,5-d][1,2,4]triazolo[4,3-a]pyrimidines were synthesized via reaction of hydrazonoyl halides with each of alkyl carbothioates, carbothioamides and 7-thioxo-5,6,7,8-tetrahydropyrimido-[4,5-d]pyrimidine-2,4(1H,3H)-diones in the presence of triethylamine. The structures of the newly synthesized compounds were established based on their spectral data, elemental analyses and alternative synthetic routes whenever possible. Also, the newly synthesized compounds were screened for their antimicrobial activity against various microorganisms.
authors.affiliation: Department of Chemistry, Faculty of Science, Cairo University, Giza 12613, Egypt. Abdelhamid45@gmail.com.
authors.forename: Abdou O
authors.initials: AO
authors.lastname: Abdelhamid
authors.affiliation: Department of Chemistry, Faculty of Science, El Menoufia University, Shebin El Koom 32511, Egypt. ibrahimtantawy@yahoo.co.uk.
authors.forename: Ibrahim E
authors.initials: IE
authors.lastname: El Sayed
authors.affiliation: Environmental Research Department, National Center for Social and Criminological Research, Ibn Khaldoun Square, Mohandesin, Zamalek, Giza 11561, Egypt. mohamedzaki1955@yahoo.com.
authors.forename: Mohamed Z
authors.initials: MZ
authors.lastname: Hussein
authors.affiliation: Environmental Research Department, National Center for Social and Criminological Research, Ibn Khaldoun Square, Mohandesin, Zamalek, Giza 11561, Egypt. mangoud_online@yahoo.com.
authors.forename: Mangoud M
authors.initials: MM
authors.lastname: Mangoud
mesh_terms: D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D005658:Fungi / Q000187:drug effects; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D011743:Pyrimidines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D013830:Thiadiazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D013854:Thioamides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology
chemical_list: D000890:Anti-Infective Agents; D011743:Pyrimidines; D013830:Thiadiazoles; D013854:Thioamides
keywords: 1,3,4-thiadiazoles; antimicrobials; hydrazonoyl halides; pyrimido[4,5-d][1,2,4]triazolo[4,3-a]pyrimidines; thiazoles; thioamides