title: Towards a multi protein and mRNA expression of biological predictive and distinguish model for post stroke depression.
abstract: Previous studies suggest that neurotrophic factors participate in the development of stroke and depression. So we investigated the utility of these biomarkers as predictive and distinguish model for post stroke depression (PSD). 159 individuals including PSD, stroke without depression (Non-PSD), major depressive disorder (MDD) and normal control groups were recruited and examined the protein and mRNA expression levels of vascular endothelial growth factor (VEGF), vascular endothelial growth factor receptors (VEGFR2), placental growth factor (PIGF), insulin-like growth factor (IGF-1) and insulin-like growth factor receptors (IGF-1R). The chi-square test was used to evaluate categorical variable, while nonparametric test and one-way analysis of variance were applied to continuous variables of general characteristics, clinical and biological changes. In order to explore the predictive and distinguish role of these factors in PSD, discriminant analysis and receiver operating characteristic curve were calculated. The four groups had statistical differences in these neurotrophic factors (all P < 0.05) except VEGF concentration and IGF-1R mRNA (P = 0.776, P = 0.102 respectively). We identified these mRNA expression and protein analytes with general predictive performance for PSD and Non-PSD groups [area under the curve (AUC): 0.805, 95% CI, 0.704-0.907, P < 0.001]. Importantly, there is an excellent predictive performance (AUC: 0.984, 95% CI, 0.964-1.000, P < 0.001) to differentiate PSD patients from MDD patients. This was the first study to explore the changes of neurotrophic factors family in PSD patients, the results intriguingly demonstrated that the combination of protein and mRNA expression of biological factors could use as a predictive and discriminant model for PSD.
authors.affiliation: Department of Psychosomatics and Psychiatry, ZhongDa Hospital, School of Medicine, Southeast University, Nanjing, PR China.|Institute of Psychosomatics, Medical School of Southeast University, Nanjing, PR China.
authors.forename: Yingying
authors.initials: Y
authors.lastname: Yue
authors.affiliation: Department of Psychosomatics and Psychiatry, ZhongDa Hospital, School of Medicine, Southeast University, Nanjing, PR China.|Institute of Psychosomatics, Medical School of Southeast University, Nanjing, PR China.
authors.forename: Haitang
authors.initials: H
authors.lastname: Jiang
authors.affiliation: School of Information Science and Engineering Southeast University, Nanjing, PR China.
authors.forename: Rui
authors.initials: R
authors.lastname: Liu
authors.affiliation: Department of Psychosomatics and Psychiatry, ZhongDa Hospital, School of Medicine, Southeast University, Nanjing, PR China.|Institute of Psychosomatics, Medical School of Southeast University, Nanjing, PR China.
authors.forename: Yingying
authors.initials: Y
authors.lastname: Yin
authors.affiliation: Department of Psychosomatics and Psychiatry, ZhongDa Hospital, School of Medicine, Southeast University, Nanjing, PR China.|Institute of Psychosomatics, Medical School of Southeast University, Nanjing, PR China.
authors.forename: Yuqun
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Department of Psychosomatics and Psychiatry, ZhongDa Hospital, School of Medicine, Southeast University, Nanjing, PR China.|Institute of Psychosomatics, Medical School of Southeast University, Nanjing, PR China.
authors.forename: Jinfeng
authors.initials: J
authors.lastname: Liang
authors.affiliation: Department of Neurology, Jiangning Nanjing Hospital, Nanjing, PR China.
authors.forename: Shenghua
authors.initials: S
authors.lastname: Li
authors.affiliation: Department of Neurology, The Affiliated First Hospital of Nanjing Medical University, Nanjing, PR China.
authors.forename: Jun
authors.initials: J
authors.lastname: Wang
authors.affiliation: Department of Neurology, The Peoples' Hospital of Gaochun County, Nanjing, PR China.
authors.forename: Jianxin
authors.initials: J
authors.lastname: Lu
authors.affiliation: Department of Neurology, Affiliated Hospital of Xuzhou Medical College, Xuzhou, PR China.
authors.forename: Deqin
authors.initials: D
authors.lastname: Geng
authors.affiliation: Department of Psychosomatics, The Affiliated First Hospital of Suzhou University, Suzhou, PR China.
authors.forename: Aiqin
authors.initials: A
authors.lastname: Wu
authors.affiliation: Department of Psychosomatics and Psychiatry, ZhongDa Hospital, School of Medicine, Southeast University, Nanjing, PR China.|Institute of Psychosomatics, Medical School of Southeast University, Nanjing, PR China.
authors.forename: Yonggui
authors.initials: Y
authors.lastname: Yuan
mesh_terms: D000368:Aged; D003863:Depression / Q000378:metabolism*; D003865:Major Depressive Disorder / Q000378:metabolism; D005260:Female; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000032:analysis / Q000235:genetics; D008297:Male; D008565:Membrane Proteins / Q000032:analysis / Q000235:genetics; D008875:Middle Aged; D012333:RNA, Messenger / Q000032:analysis; D017526:Receptor, IGF Type 1; D017451:Receptors, Somatomedin / Q000032:analysis / Q000235:genetics; D020521:Stroke / Q000523:psychology*; D040301:Vascular Endothelial Growth Factor Receptor-2 / Q000032:analysis / Q000235:genetics
chemical_list: C583557:IGF1 protein, human; C000597236:IGF1R protein, human; D008565:Membrane Proteins; C098069:PIGF protein, human; D012333:RNA, Messenger; D017451:Receptors, Somatomedin; D007334:Insulin-Like Growth Factor I; D017526:Receptor, IGF Type 1; D040301:Vascular Endothelial Growth Factor Receptor-2
keywords: Pathology Section; mRNA; neurotrophic factors; post stroke depression; protein