title: DAMP-Induced Allograft and Tumor Rejection: The Circle Is Closing.
abstract: The pathophysiological importance of the immunogenicity of damage-associated molecular patterns (DAMPs) has been pinpointed by their identification as triggers of allograft rejection following release from dying cells, such as after ischemia-reperfusion injury. In cancers, however, this strong trigger of a specific immune response gives rise to the success of cancer immunotherapy. Here, we review the recently literature on the pathophysiological importance of DAMP release and discuss the implications of these processes for allograft rejection and cancer immunotherapy, revealing a striking mechanistic overlap. We conclude that these two fields share a common mechanistic basis of regulated necrosis and inflammation, the molecular characterization of which may be helpful for both oncologists and the transplant community.
authors.affiliation: German Academy of Transplantation Medicine, Munich, Germany.|Laboratoire d'ImmunoRhumatologie Moléculaire, INSERM UMR_S1109, Plateforme GENOMAX, Faculté de Médecine, Fédération de Médecine Translationnelle de Strasbourg (FMTS), Université de Strasbourg, Strasbourg, France.|LabexTRANSPLANTEX, Faculté de Médecine, Université de Strasbourg, Strasbourg, France.
authors.forename: W G
authors.initials: WG
authors.lastname: Land
authors.affiliation: Cell Death Research and Therapy (CDRT) Lab, Department of Cellular and Molecular Medicine, KU Leuven, University of Leuven, Leuven, Belgium.
authors.forename: P
authors.initials: P
authors.lastname: Agostinis
authors.affiliation: Immunology Programme and Department of Microbiology and Immunology, Centre for Life Sciences, National University of Singapore, Singapore, Singapore.
authors.forename: S
authors.initials: S
authors.lastname: Gasser
authors.affiliation: Cell Death Research and Therapy (CDRT) Lab, Department of Cellular and Molecular Medicine, KU Leuven, University of Leuven, Leuven, Belgium.
authors.forename: A D
authors.initials: AD
authors.lastname: Garg
authors.affiliation: Division of Nephrology, Department of Internal Medicine III, University Hospital Carl Gustav Carus at the Technische Universität Dresden, Dresden, Germany.|Cluster of Excellence EXC306, Inflammation at Interfaces, Schleswig-Holstein, Germany.|Clinic for Nephrology and Hypertension, Christian-Albrechts-University, Kiel, Germany.
authors.forename: A
authors.identifier: 0000-0001-6287-9725
authors.initials: A
authors.lastname: Linkermann
mesh_terms: D064591:Allografts; D000818:Animals; D006084:Graft Rejection / Q000276:immunology* / Q000473:pathology; D006801:Humans; D007249:Inflammation / Q000503:physiopathology*; D009336:Necrosis; D009369:Neoplasms / Q000276:immunology* / Q000473:pathology; D015427:Reperfusion Injury / Q000276:immunology* / Q000473:pathology
keywords: basic (laboratory) research/science; cancer/malignancy/neoplasia; cell death; immune regulation; immunobiology; organ transplantation in general; rejection; rejection: antibody-mediated (ABMR); translational research/science