title: [Cancer cachexia and white adipose tissue browning].
abstract: Cancer cachexia occurs in a majority of advanced cancer patients. These patients with impaired physical function are unable to tolerance cancer treatment well and have a significantly reduced survival rate. Currently, there is no effective clinical treatment available for cancer cachexia, therefore, it is necessary to clarify the molecular mechanisms of cancer cachexia, moreover, new therapeutic targets for cancer cachexia treatment are urgently needed. Very recent studies suggest that, during cancer cachexia, white adipose tissue undergo a 'browning' process, resulting in increased lipid mobilization and energy expenditure, which may be necessary for the occurrence of cancer cachexia. In this article, we summarize the definition and characteristics of cancer cachexia and adipose tissue 'browning', then, we discuss the new study directions presented in latest research.
authors.affiliation: Department of Pathogen Biology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
authors.forename: S T
authors.initials: ST
authors.lastname: Zhang
authors.affiliation: Department of Pathogen Biology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
authors.forename: H M
authors.initials: HM
authors.lastname: Yang
mesh_terms: D002001:Adipose Tissue, Brown; D052436:Adipose Tissue, White; D002100:Cachexia; D004734:Energy Metabolism; D006801:Humans; D009369:Neoplasms