title: Application of receiver operating characteristic curve in the assessment of the value of body mass index, waist circumference and percentage of body fat in the Diagnosis of Polycystic Ovary Syndrome in childbearing women.
abstract: BACKGROUND
  There are various parameters to analyze obesity, however, no standard reference to predict, screen or diagnose PCOS with various obesity parameters has been established, and the accuracy of these parameters still needs to be studied.This study was to use the receiver operating characteristic (ROC) curve to explore the different values of three obesity parameters, body mass index (BMI), waist circumference (WC) and percentage of body fat (PBF) in the diagnosis of polycystic ovary syndrome (PCOS) in Chinese childbearing women.
  
  
  METHODS
  Three hundred patients who were diagnosed with PCOS at Center of Reproductive Medicine and Genetics of Peking University First Hospital were enrolled in this study, and 110 healthy age-matched women were enrolled as controls. The characteristics of BMI, WC and PBF in PCOS patients were analyzed.
  
  
  RESULTS
  Compared with the control group, all the three obesity parameters were significantly increased in PCOS group. In terms of ROC area under the curve, WC > PBF > BMI, and they were all significantly different from those of the control. At a cut-off point of 80.5 cm, WC has a sensitivity of 73.6 % and a specificity of 85 % in diagnosis of PCOS; At a cut-off point of 29 %, PBF has a sensitivity of 88.2 % and a specificity of 57.7 % in diagnosis of PCOS; and at a cut-off point of 26.6 kg/m(2), BMI has a sensitivity of 54.5 % and a specificity of 98 % in diagnosis of PCOS.
  
  
  CONCLUSIONS
  WC, BMI and PBF are valuable in screening and diagnosis of PCOS in Chinese childbearing women. PBF can be used to screen PCOS as it has a better sensitivity, while BMI can be used in the diagnosis of PCOS as it has a better specificity.
authors.affiliation: Department of Clinical Nutrition, Peking University First Hospital, Beijing, China.
authors.forename: Pan
authors.initials: P
authors.lastname: Dou
authors.affiliation: Center of Reproduction and Genetics, Peking University First Hospital, Beijing, China.
authors.forename: Huiyan
authors.initials: H
authors.lastname: Ju
authors.affiliation: Center of Reproduction and Genetics, Peking University First Hospital, Beijing, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Shang
authors.affiliation: Department of Biostatistics, Peking University First Hospital, Beijing, China.
authors.forename: Xueying
authors.initials: X
authors.lastname: Li
authors.affiliation: Center of Reproduction and Genetics, Peking University First Hospital, Beijing, China.
authors.forename: Qing
authors.initials: Q
authors.lastname: Xue
authors.affiliation: Center of Reproduction and Genetics, Peking University First Hospital, Beijing, China. xuyangm@126.com.|, No.7, Xishiku Road, Xicheng District, Beijing, 100034, People's Republic of China. xuyangm@126.com.
authors.forename: Yang
authors.initials: Y
authors.lastname: Xu
authors.affiliation: Department of Endocrinology, Peking University First Hospital, Beijing, China. guoxh@medmail.com.cn.|, No.7, Xishiku Road, Xicheng District, Beijing, 100034, People's Republic of China. guoxh@medmail.com.cn.
authors.forename: Xiaohui
authors.initials: X
authors.lastname: Guo
mesh_terms: D000293:Adolescent; D000328:Adult; D044466:Asian People; D015992:Body Mass Index; D002681:China; D005260:Female; D006801:Humans; D009765:Obesity / Q000150:complications / Q000175:diagnosis*; D011085:Polycystic Ovary Syndrome / Q000175:diagnosis*; D012372:ROC Curve; D055105:Waist Circumference; D049629:Waist-Hip Ratio; D055815:Young Adult
keywords: Area under the curve; Body mass index; Childbearing age; Obesity; Polycystic ovary syndrome; Receiver operating characteristic; Waist circumference; percentage of body fat