title: QTc prolongation during peripheral stem cell apheresis in healthy volunteers.
abstract: OBJECTIVE
  Today, voluntary donation of peripheral blood stem cells by healthy donors for allogeneic hemopoietic cell transplantation is common worldwide. Such donations are associated with small but measurable risks of morbidity and mortality. Most complications are associated with citrate infusion during cell collection. We studied the effects of citrate infusion on the QTc and other vital parameters during and after peripheral stem cell apheresis in volunteers.
  
  
  METHODS
  To ensure that donors were healthy, screening included taking a detailed medical history, physical examination, and laboratory measurements of plasma calcium and magnesium. Corrected QT (QTc) values were assessed using a 12-lead electrocardiographic platform that derived QTc values automatically.
  
  
  RESULTS
  In all, 141 apheresis procedures were performed. The mean QTc values at baseline, at 2 and 4 h during the procedure, and at 30 min after the procedure, were 347.6 ± 59.5, 349.9 ± 52.8, 391.8 ± 54.0, and 404.8 ± 59.2 ms, respectively. The baseline and 2 h QTcs did not differ significantly, but the baseline QTc did differ significantly from the 4 h and 30 min after the procedure values. The plasma levels of calcium and magnesium did not significantly differ before and after the procedure.
  
  
  CONCLUSIONS
  QTc prolongation may develop during leukopheresis, particularly if the procedure takes more than 2 h. Thus, to enhance donor safety, QTc measurement should be standard for all donors. In addition, any family history of sudden death should be noted, to prevent the development of possible fatal arrhythmia in susceptible donors.
authors.affiliation: Baskent University Adana Adult Bone Marrow Transplantation Center Clinical Unit.|Department of Family Medicine, Baskent University Medical Faculty.
authors.forename: Aslı
authors.initials: A
authors.lastname: Korur
authors.affiliation: Baskent University Adana Adult Bone Marrow Transplantation Center Apheresis and Cell Collecting Unit.|Department of Physiology, Baskent University Medical Faculty.
authors.forename: Ilknur
authors.initials: I
authors.lastname: Kozanoglu
authors.affiliation: Baskent University Adana Adult Bone Marrow Transplantation Center Clinical Unit.
authors.forename: Nurhilal
authors.initials: N
authors.lastname: Buyukkurt
authors.affiliation: Baskent University Adana Adult Bone Marrow Transplantation Center Clinical Unit.
authors.forename: Mahmut
authors.initials: M
authors.lastname: Yeral
authors.affiliation: Baskent University Adana Adult Bone Marrow Transplantation Center Apheresis and Cell Collecting Unit.
authors.forename: Fatih
authors.initials: F
authors.lastname: Kandemir
authors.affiliation: Baskent University Adana Adult Bone Marrow Transplantation Center Clinical Unit.|Department of Family Medicine, Baskent University Medical Faculty.
authors.forename: Cigdem
authors.initials: C
authors.lastname: Gereklioglu
authors.affiliation: Statistic Department, Baskent University.
authors.forename: Cagla
authors.initials: C
authors.lastname: Sariturk
authors.affiliation: Baskent University Adana Adult Bone Marrow Transplantation Center Clinical Unit.|Department of Family Medicine, Baskent University Medical Faculty.
authors.forename: Suheyl
authors.initials: S
authors.lastname: Asma
authors.affiliation: Baskent University Adana Adult Bone Marrow Transplantation Center Clinical Unit.
authors.forename: Soner
authors.initials: S
authors.lastname: Solmaz
authors.affiliation: Baskent University Adana Adult Bone Marrow Transplantation Center Clinical Unit.
authors.forename: Can
authors.initials: C
authors.lastname: Boga
authors.affiliation: Baskent University Adana Adult Bone Marrow Transplantation Center Clinical Unit.
authors.forename: Hakan
authors.initials: H
authors.lastname: Ozdogu
mesh_terms: D000293:Adolescent; D000328:Adult; D001781:Blood Component Removal / Q000379:methods*; D019343:Citric Acid / Q000008:administration & dosage; D003430:Cross-Sectional Studies; D004562:Electrocardiography / Q000592:standards*; D005260:Female; D064368:Healthy Volunteers; D006801:Humans; D007937:Leukapheresis; D008297:Male; D008487:Medical History Taking; D008875:Middle Aged; D000072916:Peripheral Blood Stem Cells / Q000166:cytology*; D011446:Prospective Studies; D013997:Time Factors; D014019:Tissue Donors; D055815:Young Adult
chemical_list: D019343:Citric Acid
keywords: QTc prolongation; donor health; stem cell apheresis