title: Red Wine Inhibits Aggregation and Increases ATP-diphosphohydrolase (CD39) Activity of Rat Platelets in Vitro.
abstract: Moderate consumption of red wine has been shown to exert a peculiar cardioprotective effect compared with other alcoholic beverages; inhibition of platelet aggregation seems to be one of the mechanisms underlying this beneficial effect. CD39/ATP-diphosphohydrolase is an integral membrane glycoprotein metabolizing ATP and ADP to AMP; in concert with CD73/ecto-5'-nucleotidase, it contributes to extracellular adenosine accumulation. CD39 is considered a key modulator of thrombus formation; it inhibits platelet aggregation by promoting ADP hydrolysis. There is evidence that red wine consumption increases CD39 activity in platelets from streptozotocin-induced diabetic rats. Here we show that two kinds of Aglianico red wines inhibit aggregation and increase ATP--and ADPase activity in rat platelets.
authors.forename: Elisabetta
authors.initials: E
authors.lastname: Caiazzo
authors.forename: Idolo
authors.initials: I
authors.lastname: Tedesco
authors.forename: Carmela
authors.initials: C
authors.lastname: Spagnuolo
authors.forename: Gian Luigi
authors.initials: GL
authors.lastname: Russo
authors.forename: Armando
authors.initials: A
authors.lastname: Ialenti
authors.forename: Carla
authors.initials: C
authors.lastname: Cicala
mesh_terms: D000244:Adenosine Diphosphate / Q000378:metabolism; D000818:Animals; D015703:Antigens, CD / Q000378:metabolism*; D001081:Apyrase / Q000378:metabolism*; D001792:Blood Platelets / Q000166:cytology / Q000201:enzymology*; D003921:Diabetes Mellitus, Experimental / Q000201:enzymology* / Q000503:physiopathology; D006801:Humans; D008297:Male; D010974:Platelet Aggregation; D051381:Rats; D017208:Rats, Wistar; D014920:Wine / Q000032:analysis*
chemical_list: D015703:Antigens, CD; D000244:Adenosine Diphosphate; D001081:Apyrase; C067869:CD39 antigen