title: Prevalence of Medical Conditions Potentially Amenable to Cellular Therapy among Families Privately Storing Umbilical Cord Blood.
abstract: Introduction Little is known about the prevalence of conditions potentially amenable to cellular therapy among families storing umbilical cord blood in private cord blood banks. Methods A cross-sectional study of families with at least one child who stored umbilical cord blood in the largest private cord blood bank in the United States was performed. Respondent families completed a questionnaire to determine whether children with stored cord blood or a first-degree relative had one or more of 16 conditions amenable primarily to allogeneic stem cell transplant ("transplant indications") or 16 conditions under investigation for autologous stem cell infusion ("regenerative indications"), regardless of whether they received a transplant or infusion. Results 94,803 families responded, representing 33.3 % of those surveyed. Of respondent families, 16.01 % indicated at least one specified condition. 1.64 % reported at least one first-degree member with a transplant indication potentially treatable with an allogeneic stem cell transplant. The most common transplant indications reported among first-degree family members were Non-Hodgkin's Lymphoma (0.33 %), Hodgkin's Lymphoma (0.30 %), and Acute Lymphoblastic Leukemia (0.28 %). 4.23 % reported at least one child with a regenerative indication potentially treatable with an autologous stem cell infusion. The most common regenerative indications among children with stored umbilical cord blood were Autism/Autism Spectrum Disorder/Apraxia (1.93 %), Other Developmental Delay (1.36 %), and Congenital Heart Defect (0.87 %). Discussion Among families storing umbilical cord blood in private cord blood banks, conditions for which stem cell transplant or infusion may be indicated, or are under investigation, appear to be prevalent, especially for regenerative medicine indications.
authors.affiliation: Mazonson & Santas, Inc., 15 Hillcrest Avenue, Larkspur, CA, 94939, USA.
authors.forename: Peter
authors.initials: P
authors.lastname: Mazonson
authors.affiliation: Mazonson & Santas, Inc., 15 Hillcrest Avenue, Larkspur, CA, 94939, USA. mkane@clearcosthealth.com.
authors.forename: Mark
authors.initials: M
authors.lastname: Kane
authors.affiliation: Mazonson & Santas, Inc., 15 Hillcrest Avenue, Larkspur, CA, 94939, USA.
authors.forename: Kelin
authors.initials: K
authors.lastname: Colberg
authors.affiliation: Scientific and Medical Affairs, CBR Systems, Inc., 1200 Bayhill Drive, 3rd Floor, San Bruno, CA, 94066, USA.
authors.forename: Heather
authors.initials: H
authors.lastname: Harris
authors.affiliation: Scientific and Medical Affairs, CBR Systems, Inc., 1200 Bayhill Drive, 3rd Floor, San Bruno, CA, 94066, USA.
authors.forename: Heather
authors.initials: H
authors.lastname: Brown
authors.affiliation: Mazonson & Santas, Inc., 15 Hillcrest Avenue, Larkspur, CA, 94939, USA.
authors.forename: Andrew
authors.initials: A
authors.lastname: Mohr
authors.affiliation: Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, 10833 Le Conte Avenue, Los Angeles, CA, 90095, USA.
authors.forename: Alyssa
authors.initials: A
authors.lastname: Ziman
authors.affiliation: Mazonson & Santas, Inc., 15 Hillcrest Avenue, Larkspur, CA, 94939, USA.
authors.forename: Chris
authors.initials: C
authors.lastname: Santas
mesh_terms: D000740:Anemia / Q000235:genetics / Q000628:therapy; D036101:Cord Blood Stem Cell Transplantation / Q000379:methods* / Q000706:statistics & numerical data; D003430:Cross-Sectional Studies; D005312:Fetal Blood / Q000166:cytology*; D006801:Humans; D007938:Leukemia / Q000235:genetics / Q000628:therapy; D008223:Lymphoma / Q000235:genetics / Q000628:therapy; D008421:Materials Management, Hospital / Q000379:methods / Q000706:statistics & numerical data; D015995:Prevalence; D044968:Regenerative Medicine / Q000379:methods / Q000706:statistics & numerical data; D012509:Sarcoma / Q000235:genetics / Q000628:therapy; D011795:Surveys and Questionnaires; D014481:United States
keywords: Blood bank; Cord blood stem cell transplantation; Hematopoietic stem cells; Regenerative medicine; Stem cell transplant; Umbilical cord blood