title: Vestaines, novel vasoactive compounds, isolated from Streptomyces sp. SANK 63697.
abstract: We conducted a screening program for vasoactive compounds and detected a potent activity in the cultured broth of Streptomyces sp. SANK 63697. From the cultured broth, two active compounds, vestaine A1and B1, were isolated. The structures of these compounds were elucidated by physicochemical data and spectral analyses, and found to be new compounds.
authors.affiliation: Discovery Science and Technology Department, Daiichi Sankyo RD Novare, Tokyo, Japan.
authors.forename: Yuki
authors.initials: Y
authors.lastname: Hirota-Takahata
authors.affiliation: Discovery Science and Technology Department, Daiichi Sankyo RD Novare, Tokyo, Japan.
authors.forename: Emi
authors.initials: E
authors.lastname: Kurosawa
authors.affiliation: Frontier Research Laboratories, Daiichi Sankyo, Tokyo, Japan.
authors.forename: Yoko
authors.initials: Y
authors.lastname: Ishimoto
authors.affiliation: Discovery Science and Technology Department, Daiichi Sankyo RD Novare, Tokyo, Japan.
authors.forename: Yuko
authors.initials: Y
authors.lastname: Iwadate
authors.affiliation: Discovery Science and Technology Department, Daiichi Sankyo RD Novare, Tokyo, Japan.
authors.forename: Masaaki
authors.initials: M
authors.lastname: Kizuka
authors.affiliation: Medicinal Chemistry Research Laboratories, Daiichi Sankyo, Tokyo, Japan.
authors.forename: Jun
authors.initials: J
authors.lastname: Chiba
authors.affiliation: Organic Synthesis Department, Daiichi Sankyo RD Novare, Tokyo, Japan.
authors.forename: Toru
authors.initials: T
authors.lastname: Hasegawa
authors.affiliation: Discovery Science and Technology Department, Daiichi Sankyo RD Novare, Tokyo, Japan.
authors.forename: Masahiro
authors.initials: M
authors.lastname: Tanaka
authors.affiliation: Frontier Research Laboratories, Daiichi Sankyo, Tokyo, Japan.
authors.forename: Hideki
authors.initials: H
authors.lastname: Kobayashi
mesh_terms: D000111:Acetylcysteine / Q000031:analogs & derivatives* / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D002317:Cardiovascular Agents / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D018920:Coculture Techniques; D042783:Endothelial Cells / Q000187:drug effects; D005347:Fibroblasts / Q000187:drug effects; D006801:Humans; D015394:Molecular Structure; D000644:Quaternary Ammonium Compounds / Q000737:chemistry / Q000378:metabolism* / Q000494:pharmacology; D013302:Streptomyces / Q000378:metabolism*
chemical_list: D002317:Cardiovascular Agents; D000644:Quaternary Ammonium Compounds; C000613967:vestaine A1; C000618149:vestaine B1; D000111:Acetylcysteine