title: A-to-I RNA editing independent of ADARs in filamentous fungi.
abstract: ADAR mediated A-to-I RNA editing is thought to be unique to animals and occurs mainly in the non-coding regions. Recently filamentous fungi such as Fusarium graminearum were found to lack orthologs of animal ADARs but have stage-specific A-to-I editing during sexual reproduction. Unlike animals, majority of editing sites are in the coding regions and often result in missense and stop loss changes in fungi. Furthermore, whereas As in RNA stems are targeted by animal ADARs, RNA editing in fungi preferentially targets As in hairpin loops, implying that fungal RNA editing involves mechanisms related to editing of the anticodon loop by ADATs. Identification and characterization of fungal adenosine deaminases and their stage-specific co-factors may be helpful to understand the evolution of human ADARs. Fungi also can be used to study biological functions of missense and stop loss RNA editing events in eukaryotic organisms.
authors.affiliation: a State Key Laboratory of Crop Stress Biology for Arid Areas, College of Plant Protection, Northwest A&F University , Yangling , Shaanxi , China.|b Department of Botany and Plant Pathology, Purdue University , West Lafayette , IN , USA.
authors.forename: Chenfang
authors.initials: C
authors.lastname: Wang
authors.affiliation: b Department of Botany and Plant Pathology, Purdue University , West Lafayette , IN , USA.
authors.forename: Jin-Rong
authors.initials: JR
authors.lastname: Xu
authors.affiliation: a State Key Laboratory of Crop Stress Biology for Arid Areas, College of Plant Protection, Northwest A&F University , Yangling , Shaanxi , China.
authors.forename: Huiquan
authors.initials: H
authors.lastname: Liu
keywords: Adenosine deaminases, Fusarium, Inosine, Neurospora, RNA editing