title: Can reduced field-of-view diffusion sequence help assess microsatellite instability in FIGO stage 1 endometrial cancer?
abstract: To determine if a reduced-field-of-view (rFOV) diffusion intravoxel incoherent motion (IVIM) sequence can differentiate the imaging characteristics of tumors with microsatellite instability (MSI) from those that are microsatellite stable (MSS) in patients with clinical FIGO stage IA endometrial cancer and if MRI can be used to determine MSI status.
  
  
  
  Sagittal rFOV diffusion-weighted images were obtained in 12 patients on a 3T scanner using six b-values (0, 50, 100, 150, 200, and 600). These images were used to derive apparent diffusion coefficient (ADC), true diffusion coefficient (Dt), pseudodiffusion (D*), and perfusion fraction (f). Regions of interest (ROIs) were drawn on the dynamic contrast-enhanced magnetic resonance imaging (MRI) sequence on an Advantage Windows workstation and were copied to the same location on IVIM-derived images. The ROI mean of these images was recorded and compared with the microsatellite status. The depth of myometrial invasion and IVIM-derived parameters were tabulated by microsatellite status. The Wilcoxon rank sum test was used to compare T1postcontrast images and IVIM-derived images and microsatellite status.
  
  
  
  Six patients had MSS tumors and six had MSI tumors. MSS tumors had a significantly higher ADC value (P = 0.03) and Dt(P = 0.045) than the MSI tumors. There was no association between < and ≥ 50% depth of myometrial invasion (measured on pathology and MRI analysis) and MSI stability P > 0.99.
  
  
  
  IVIM, ADC and Dtmay be able to determine microsatellite status noninvasively in patients with clinical FIGO stage I endometrial cancer.
  
  
  
  1 J. Magn. Reson. Imaging 2017;45:1216-1224.
authors.affiliation: Department of Diagnostic Radiology, University of Texas M. D. Anderson Cancer Center, Houston, Texas, USA.
authors.forename: Priya
authors.initials: P
authors.lastname: Bhosale
authors.affiliation: Department of Pathology, University of Texas M. D. Anderson Cancer Center, Houston, Texas, USA.
authors.forename: Preetha
authors.initials: P
authors.lastname: Ramalingam
authors.affiliation: Department of Physics, University of Texas M. D. Anderson Cancer Center, Houston, Texas, USA.
authors.forename: Jingfei
authors.initials: J
authors.lastname: Ma
authors.affiliation: Department of Diagnostic Radiology, University of Texas M. D. Anderson Cancer Center, Houston, Texas, USA.
authors.forename: Revathy
authors.initials: R
authors.lastname: Iyer
authors.affiliation: Department of Gynecologic Oncology, University of Texas M. D. Anderson Cancer Center, Houston, Texas, USA.
authors.forename: Pamela
authors.initials: P
authors.lastname: Soliman
authors.affiliation: Department of Gynecologic Oncology, University of Texas M. D. Anderson Cancer Center, Houston, Texas, USA.
authors.forename: Micheal
authors.initials: M
authors.lastname: Frumovitz
authors.affiliation: Department of Diagnostic Radiology, University of Texas M. D. Anderson Cancer Center, Houston, Texas, USA.
authors.forename: Vikas
authors.initials: V
authors.lastname: Kundra
mesh_terms: D000328:Adult; D000368:Aged; D003937:Diagnosis, Differential; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods*; D016889:Endometrial Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology*; D004717:Endometrium / Q000000981:diagnostic imaging / Q000473:pathology; D005260:Female; D006801:Humans; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D053842:Microsatellite Instability; D008875:Middle Aged; D011446:Prospective Studies
keywords: FIGO stage IA; MRI; diffusion; endometrial cancer; intravoxel incoherent motion; microsatellite instability; microsatellite stability