title: Pre-surgical depression and anxiety and recovery following coronary artery bypass graft surgery.
abstract: We aimed to explore the combined contribution of pre-surgical depression and anxiety symptoms for recovery following coronary artery bypass graft (CABG) using data from 251 participants. Participants were assessed prior to surgery for depression and anxiety symptoms and followed up at 12 months to assess pain and physical symptoms, while hospital emergency admissions and death/major adverse cardiac events (MACE) were monitored on average 2.68 years after CABG. After controlling for covariates, baseline anxiety symptoms, but not depression, were associated with greater pain (β = 0.231, p = 0.014) and greater physical symptoms (β = 0.194, p = 0.034) 12 months after surgery. On the other hand, after controlling for covariates, baseline depression symptoms, but not anxiety, were associated with greater odds of having an emergency admission (OR 1.088, CI 1.010-1.171, p = 0.027) and greater hazard of death/MACE (HR 1.137, CI 1.042-1.240, p = 0.004). These findings point to different pathways linking mood symptoms with recovery after CABG surgery.
authors.affiliation: Department of Epidemiology and Public Health, University College London, 1-19 Torrington Place, London, WC1E 6BT, UK. lydia.poole.09@ucl.ac.uk.
authors.forename: Lydia
authors.initials: L
authors.lastname: Poole
authors.affiliation: Department of Epidemiology and Public Health, University College London, 1-19 Torrington Place, London, WC1E 6BT, UK.
authors.forename: Amy
authors.initials: A
authors.lastname: Ronaldson
authors.affiliation: Department of Epidemiology and Public Health, University College London, 1-19 Torrington Place, London, WC1E 6BT, UK.
authors.forename: Tara
authors.initials: T
authors.lastname: Kidd
authors.affiliation: Department of Epidemiology and Public Health, University College London, 1-19 Torrington Place, London, WC1E 6BT, UK.
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Leigh
authors.affiliation: Department of Cardiac Surgery, St George's Hospital, University of London, Blackshaw Road, London, SW17 0QT, UK.
authors.forename: Marjan
authors.initials: M
authors.lastname: Jahangiri
authors.affiliation: Department of Epidemiology and Public Health, University College London, 1-19 Torrington Place, London, WC1E 6BT, UK.
authors.forename: Andrew
authors.initials: A
authors.lastname: Steptoe
mesh_terms: D000339:Affect; D000368:Aged; D001007:Anxiety / Q000523:psychology*; D001026:Coronary Artery Bypass / Q000523:psychology*; D003863:Depression / Q000523:psychology*; D005260:Female; D006760:Hospitalization; D006801:Humans; D008297:Male; D008875:Middle Aged; D057234:Preoperative Period; D011569:Psychiatric Status Rating Scales; D020127:Recovery of Function
keywords: Anxiety; Coronary artery bypass graft surgery; Depression; Longitudinal study; Major adverse cardiac events; Pain; Recovery