title: Anaphylaxis to Polyethylene Glycol (Colyte®) in a Patient with Diverticulitis.
abstract: Polyethylene glycols (PEGs) are believed to be chemically inert agents, but larger PEG polymers could have immunogenicity. A 39-year-old man was referred to emergency room for loss of consciousness and dyspnea after taking of PEG-3350 (Colyte®). In laboratory findings, the initial serum tryptase level was increased to 91.9 mg/L (normal range: 0.00-11.40 mg/L) without any other laboratory abnormalities. The intradermal test with 10 mg/mL Colyte® showed a 5 × 5 mm wheal, but basophil activation and histamine releasability tests were negative. PEG-3350 is widely used as an osmotic laxative due to its lack of absorption from the gastrointestinal tract. However, the loss of mucosal integrity at gastrointestinal membrane such as diverticulitis may be a predisposing factor for anaphylaxis to Colyte®. We report a case of anaphylaxis induced by the ingestion of PEG-3350 in a patient with diverticulitis which might be a risk factor of anaphylaxis.
authors.affiliation: Department of Allergy and Clinical Immunology, Ajou University School of Medicine, Suwon, Korea.
authors.forename: So Hee
authors.identifier: http://orcid.org/0000-0001-7124-9434
authors.initials: SH
authors.lastname: Lee
authors.affiliation: Department of Allergy and Clinical Immunology, Ajou University School of Medicine, Suwon, Korea.
authors.forename: Sun Hyuk
authors.identifier: http://orcid.org/0000-0002-8454-0068
authors.initials: SH
authors.lastname: Hwang
authors.affiliation: Department of Allergy and Clinical Immunology, Ajou University School of Medicine, Suwon, Korea.
authors.forename: Jin Soo
authors.identifier: http://orcid.org/0000-0001-7808-6316
authors.initials: JS
authors.lastname: Park
authors.affiliation: Department of Allergy and Clinical Immunology, Ajou University School of Medicine, Suwon, Korea.
authors.forename: Hae Sim
authors.identifier: http://orcid.org/0000-0003-2614-0303
authors.initials: HS
authors.lastname: Park
authors.affiliation: Department of Allergy and Clinical Immunology, Ajou University School of Medicine, Suwon, Korea. drsys93@naver.com.
authors.forename: Yoo Seob
authors.identifier: http://orcid.org/0000-0002-9855-3185
authors.initials: YS
authors.lastname: Shin
mesh_terms: D000328:Adult; D000707:Anaphylaxis / Q000139:chemically induced / Q000175:diagnosis*; D004238:Diverticulitis / Q000150:complications* / Q000175:diagnosis; D004573:Electrolytes / Q000009:adverse effects*; D006801:Humans; D008297:Male; D011092:Polyethylene Glycols / Q000009:adverse effects*; D012307:Risk Factors; D012882:Skin Tests; D053802:Tryptases / Q000097:blood
chemical_list: D004573:Electrolytes; C033608:Golytely; D011092:Polyethylene Glycols; D053802:Tryptases
keywords: Anaphylaxis; Diverticulitis; Polyethylene Glycols (PEG)