title: A new piperidine alkaloid from the leaves of Microcos paniculata L.
abstract: A new piperidine alkaloid, microcosamine C (1), and one known compound, microcosamine A (2) were isolated from the leaves of Microcos paniculata. Structure elucidation was carried out using HR-ESI-MS, 1D and 2D NMR spectroscopic methods and by comparison with data reported in the literature. The absolute configuration at the C-3 hydroxy group of 1 was established by a Mosher esterification procedure. Both the isolates (1-2) were evaluated for cytotoxicity against four selected tumour cell lines and showed only weak activity against RAW 264.7 cell line.
authors.affiliation: a Technology and Engineering Center for Marine Biomedical Resource Utilization, Xiamen Medical College , Fujian Province University , Xiamen , P.R. China.
authors.forename: Gang
authors.initials: G
authors.lastname: Zhang
authors.affiliation: b Department of Pharmacy , Xiamen Medical College , Xiamen , P.R. China.
authors.forename: Na
authors.initials: N
authors.lastname: Zhang
authors.affiliation: a Technology and Engineering Center for Marine Biomedical Resource Utilization, Xiamen Medical College , Fujian Province University , Xiamen , P.R. China.
authors.forename: Li
authors.initials: L
authors.lastname: Xu
authors.affiliation: c Department of Medical Technology , Xiamen Medical College , Xiamen , P.R. China.
authors.forename: Hong-Tan
authors.initials: HT
authors.lastname: Wu
authors.affiliation: a Technology and Engineering Center for Marine Biomedical Resource Utilization, Xiamen Medical College , Fujian Province University , Xiamen , P.R. China.
authors.forename: Dan
authors.initials: D
authors.lastname: Chen
authors.affiliation: b Department of Pharmacy , Xiamen Medical College , Xiamen , P.R. China.
authors.forename: Qi-Huang
authors.initials: QH
authors.lastname: Lin
authors.affiliation: a Technology and Engineering Center for Marine Biomedical Resource Utilization, Xiamen Medical College , Fujian Province University , Xiamen , P.R. China.
authors.forename: Lian-Zhong
authors.initials: LZ
authors.lastname: Luo
mesh_terms: D000470:Alkaloids / Q000737:chemistry* / Q000302:isolation & purification; D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology; D045744:Cell Line, Tumor; D002470:Cell Survival; D002681:China; D006801:Humans; D019660:Malvaceae / Q000737:chemistry*; D051379:Mice; D008968:Molecular Conformation; D010880:Piperidines / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D010936:Plant Extracts / Q000737:chemistry; D018515:Plant Leaves / Q000737:chemistry*; D000067996:RAW 264.7 Cells; D021241:Spectrometry, Mass, Electrospray Ionization; D013056:Spectrophotometry, Ultraviolet
chemical_list: D000470:Alkaloids; D000972:Antineoplastic Agents, Phytogenic; D010880:Piperidines; D010936:Plant Extracts; C000617919:microcosamine C
keywords: Microcos paniculata; Piperidine alkaloids; cytotoxicity