title: A Molecular Basis for Innovation in Drug Excipients.
abstract: Excipients are ubiquitous in drug formulation, ensuring that active ingredient drugs are properly released on dosing, retain their properties over time, and are palatable, among other roles. Despite their crucial roles, surprisingly little is known about their systemic availability and activities on molecular targets. Here we review key excipient properties, introduce a public-accessible database that enumerates and categorizes them, and sketch a strategy for exploring their possible direct actions on molecular targets.
authors.affiliation: Department of Pharmaceutical Chemistry & QB3 Institute, University of California, San Francisco, California, USA.
authors.forename: J J
authors.initials: JJ
authors.lastname: Irwin
authors.affiliation: Department of Pharmaceutical Chemistry & QB3 Institute, University of California, San Francisco, California, USA.
authors.forename: J
authors.initials: J
authors.lastname: Pottel
authors.affiliation: Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, California, USA.
authors.forename: L
authors.initials: L
authors.lastname: Zou
authors.affiliation: Food & Drug Administration, Silver Spring, Maryland, USA.
authors.forename: H
authors.initials: H
authors.lastname: Wen
authors.affiliation: Food & Drug Administration, Silver Spring, Maryland, USA.
authors.forename: S
authors.initials: S
authors.lastname: Zuk
authors.affiliation: Food & Drug Administration, Silver Spring, Maryland, USA.
authors.forename: X
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Department of Pharmaceutical Chemistry & QB3 Institute, University of California, San Francisco, California, USA.
authors.forename: T
authors.initials: T
authors.lastname: Sterling
authors.affiliation: Department of Pharmaceutical Chemistry & QB3 Institute, University of California, San Francisco, California, USA.
authors.forename: B K
authors.initials: BK
authors.lastname: Shoichet
authors.affiliation: Food & Drug Administration, Silver Spring, Maryland, USA.
authors.forename: R
authors.initials: R
authors.lastname: Lionberger
authors.affiliation: Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, California, USA.
authors.forename: K M
authors.initials: KM
authors.lastname: Giacomini
mesh_terms: D002626:Chemistry, Pharmaceutical / Q000458:organization & administration*; D016208:Databases, Factual; D016568:Drugs, Generic; D005079:Excipients / Q000737:chemistry*; D006801:Humans; D012106:Research; D014481:United States; D014486:United States Food and Drug Administration
chemical_list: D016568:Drugs, Generic; D005079:Excipients