title: Congenital Chikungunya Virus Infection after an Outbreak in Salvador, Bahia, Brazil.
abstract: There is little information about the congenital chikungunya virus (CHIKV) transmission. We describe two cases of well-documented congenital CHIKV infection in Salvador-Brazil, where CHIKV has been identified since 2014. The outbreak in the city led to the clinical CHIKV diagnoses of both pregnant women 2 days before delivery. Urine and blood samples from the mothers and newborns were collected and tested for reverse transcription-polymerase chain reaction (PCR) analysis for Zika, dengue, and CHIKV. Both neonates and mothers had positive urine and serum PCR results for CHIKV. The newborns had significant perinatal complications and were admitted to the neonatal intensive care unit. The purpose of our case report is to show how severe congenital CHIKV infection can be and the importance to include CHIKV infection in the differential diagnosis of neonatal sepsis when mothers have clinical signs of the disease and live in an affected area.
authors.affiliation: Department of Pediatrics, Climério de Oliveira Maternity, Federal University of Bahia School of Medicine, Bahia, Brazil.
authors.forename: Priscila Pinheiro Ribeiro
authors.initials: PP
authors.lastname: Lyra
authors.affiliation: Laboratory of Virology, Health Science Institute, Federal University of Bahia, Bahia, Brazil.
authors.forename: Gúbio Soares
authors.initials: GS
authors.lastname: Campos
authors.affiliation: Department of Pediatrics, Climério de Oliveira Maternity, Federal University of Bahia School of Medicine, Bahia, Brazil.
authors.forename: Igor Dórea
authors.initials: ID
authors.lastname: Bandeira
authors.affiliation: Laboratory of Virology, Health Science Institute, Federal University of Bahia, Bahia, Brazil.
authors.forename: Silvia Ines
authors.initials: SI
authors.lastname: Sardi
authors.affiliation: Laboratory of Virology, Health Science Institute, Federal University of Bahia, Bahia, Brazil.
authors.forename: Lilian Ferreira de Moura
authors.initials: LF
authors.lastname: Costa
authors.affiliation: Laboratory of Virology, Health Science Institute, Federal University of Bahia, Bahia, Brazil.
authors.forename: Flávia Rocha
authors.initials: FR
authors.lastname: Santos
authors.affiliation: Department of Pediatrics, Climério de Oliveira Maternity, Federal University of Bahia School of Medicine, Bahia, Brazil.
authors.forename: Carlos Alexandre Santos
authors.initials: CA
authors.lastname: Ribeiro
authors.affiliation: Department of Pediatrics, Climério de Oliveira Maternity, Federal University of Bahia School of Medicine, Bahia, Brazil.
authors.forename: Alena Maria Barreto
authors.initials: AM
authors.lastname: Jardim
authors.affiliation: Department of Pediatrics, Climério de Oliveira Maternity, Federal University of Bahia School of Medicine, Bahia, Brazil.
authors.forename: Ana Cecília Travassos
authors.initials: AC
authors.lastname: Santiago
authors.affiliation: Department of Pediatrics, Climério de Oliveira Maternity, Federal University of Bahia School of Medicine, Bahia, Brazil.
authors.forename: Patrícia Maria Ribeiro
authors.initials: PM
authors.lastname: de Oliveira
authors.affiliation: Department of Pediatrics, Climério de Oliveira Maternity, Federal University of Bahia School of Medicine, Bahia, Brazil.
authors.forename: Lícia Maria Oliveira
authors.initials: LM
authors.lastname: Moreira
keywords: chikungunya; congenital; infection; newborn