title: Iridium(III)-Catalyzed Tandem [3 + 2] Annulation: Synthesis of Spirocyclic Phosphoramide Derivatives.
abstract: A highly efficient iridium(III)-catalyzed C-H activation/tandem Grignard-type [3 + 2] annulation process was developed for the synthesis of novel spirocyclic phosphoramide derivatives. Compared with other transition-metal catalysts, [Cp*IrCl2]2 exhibited favorite efficiency and best selectivity in this cascade reaction. The strategy could be applied to further construct more complex heterocyclic compounds.
authors.affiliation: Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry, West China School of Pharmacy, Sichuan University , Chengdu 610041, China.|Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences , Chengdu 610041, China.
authors.forename: Shuai-Shuai
authors.initials: SS
authors.lastname: Li
authors.affiliation: Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry, West China School of Pharmacy, Sichuan University , Chengdu 610041, China.
authors.forename: Lin
authors.initials: L
authors.lastname: Wu
authors.affiliation: Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry, West China School of Pharmacy, Sichuan University , Chengdu 610041, China.
authors.forename: Liu
authors.initials: L
authors.lastname: Qin
authors.affiliation: Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry, West China School of Pharmacy, Sichuan University , Chengdu 610041, China.
authors.forename: Yu-Qin
authors.initials: YQ
authors.lastname: Zhu
authors.affiliation: Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry, West China School of Pharmacy, Sichuan University , Chengdu 610041, China.
authors.forename: Fu
authors.initials: F
authors.lastname: Su
authors.affiliation: Xinjiang Technical Institute of Physics & Chemistry, Chinese Academy of Sciences , Urumqi 830011, China.
authors.forename: Yan-Jun
authors.initials: YJ
authors.lastname: Xu
authors.affiliation: Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry, West China School of Pharmacy, Sichuan University , Chengdu 610041, China.
authors.forename: Lin
authors.initials: L
authors.lastname: Dong