title: PET imaging of recurrent and metastatic prostate cancer with novel tracers.
abstract: Early detection of recurrent prostate cancer (PCa) is of paramount importance to deliver prompt and accurate therapy reducing the chance of progression to metastatic disease. However, current imaging modalities such as conventional computed tomography, MRI and PET scanning do not provide sufficient sensitivity, especially at lower prostate-specific antigen values. Moreover, biological characterization of PCa has become increasingly important to provide patient-specific therapy and current imaging poorly characterizes disease aggressiveness. The current uprise of novel PET tracers in recurrent and metastatic PCa shows promising, yet variable sensitivities and specificities in detection, indicating the need for further studies. In this review, we highlight current and new PET tracers that have been developed to improve the detection of recurrent and metastatic PCa.
authors.affiliation: Molecular Imaging Program, National Cancer Institute, NIH, Bethesda, MD, USA.
authors.forename: Francesca V
authors.initials: FV
authors.lastname: Mertan
authors.affiliation: Molecular Imaging Program, National Cancer Institute, NIH, Bethesda, MD, USA.
authors.forename: Liza
authors.initials: L
authors.lastname: Lindenberg
authors.affiliation: Molecular Imaging Program, National Cancer Institute, NIH, Bethesda, MD, USA.
authors.forename: Peter L
authors.initials: PL
authors.lastname: Choyke
authors.affiliation: Molecular Imaging Program, National Cancer Institute, NIH, Bethesda, MD, USA.
authors.forename: Baris
authors.initials: B
authors.lastname: Turkbey
mesh_terms: D000951:Antigens, Neoplasm / Q000378:metabolism; D014408:Biomarkers, Tumor; D006801:Humans; D008297:Male; D008565:Membrane Proteins / Q000378:metabolism; D009362:Neoplasm Metastasis; D009364:Neoplasm Recurrence, Local; D049268:Positron-Emission Tomography / Q000379:methods*; D011471:Prostatic Neoplasms / Q000000981:diagnostic imaging* / Q000378:metabolism / Q000473:pathology*; D011849:Radioactive Tracers
chemical_list: D000951:Antigens, Neoplasm; D014408:Biomarkers, Tumor; D008565:Membrane Proteins; D011849:Radioactive Tracers
keywords: PET; biochemical recurrence; prostate cancer