title: Anti-aging pharmacology: Promises and pitfalls.
abstract: Life expectancy has grown dramatically in modern times. This increase, however, is not accompanied by the same increase in healthspan. Efforts to extend healthspan through pharmacological agents targeting aging-related pathological changes are now in the spotlight of geroscience, the main idea of which is that delaying of aging is far more effective than preventing the particular chronic disorders. Currently, anti-aging pharmacology is a rapidly developing discipline. It is a preventive field of health care, as opposed to conventional medicine which focuses on treating symptoms rather than root causes of illness. A number of pharmacological agents targeting basic aging pathways (i.e., calorie restriction mimetics, autophagy inducers, senolytics etc.) are now under investigation. This review summarizes the literature related to advances, perspectives and challenges in the field of anti-aging pharmacology.
authors.affiliation: D.F. Chebotarev Institute of Gerontology, NAMS, Kiev, Ukraine. Electronic address: vaiserman@geront.kiev.ua.
authors.forename: Alexander M
authors.initials: AM
authors.lastname: Vaiserman
authors.affiliation: Vasyl Stefanyk Precarpathian National University, Ivano-Frankivsk, Ukraine.
authors.forename: Oleh V
authors.initials: OV
authors.lastname: Lushchak
authors.affiliation: D.F. Chebotarev Institute of Gerontology, NAMS, Kiev, Ukraine.
authors.forename: Alexander K
authors.initials: AK
authors.lastname: Koliada
mesh_terms: D000375:Aging / Q000187:drug effects*; D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use; D001343:Autophagy / Q000187:drug effects; D031204:Caloric Restriction / Q000379:methods; D006801:Humans; D008017:Life Expectancy
chemical_list: D000975:Antioxidants
keywords: Age-related pathology; Anti-aging drug; Antioxidant; Calorie restriction mimetic; Healthspan; Lifespan