title: Danish trends in pharmacotherapy, comorbidities, and demographics in patients referred for coronary angiography: what changed during a decade?
abstract: Coronary angiography holds a central role in the diagnosis of coronary heart disease. We studied temporal trends in referral patterns 2000-09.
  
  
  
  We identified 156 496 first-time coronary angiographies in 2000-09 in nationwide registries. Trends were analyzed in 2-year intervals. Numbers of acute (5943-10 707) and elective (17 294-25 550) procedures increased between 2000-01 and 2008-09. Mean age increased from 61.8 to 63.9 years (P < 0.001) and the proportion of females increased from 33 to 37% (P < 0.001). An increase in the number of patients with prior chronic heart failure (2866 vs. 3197), cerebrovascular disease (1790 vs. 2906), diabetes (2527 vs. 4593), and arrhythmias (2985 vs. 4733) was observed. The proportion of acute patients examined the same day as hospitalized increased from 56.6 to 83.1%. Odds ratios (95% confidence interval) for treatment with statins [3.42(3.27;3.57)], RAS-inhibitors [1.85(1.77;1.93)], and acetylsalicylic acid [1.43(1.37;1.49)] at the time of coronary angiography increased towards 2008-09. Elective patients received medical treatment more often than acute patients (P < 0.001).
  
  
  
  During a 10-year period, there was an increase in the mean age of patients and the proportion of female patients, and a 56% increase in number of coronary angiographies performed. The use of prophylactic cardiovascular drugs among these high-risk patients increased during our study period.
authors.affiliation: The Cardiovascular Research Center, Gentofte University Hospital, Hellerup, Denmark National Institute of Public Health, University of Southern Denmark, Odense, Denmark mads.emil.joergensen@regionh.dk.
authors.forename: Mads E
authors.initials: ME
authors.lastname: Jørgensen
authors.affiliation: The Cardiovascular Research Center, Gentofte University Hospital, Hellerup, Denmark.
authors.forename: Charlotte
authors.initials: C
authors.lastname: Andersson
authors.affiliation: The Cardiovascular Research Center, Gentofte University Hospital, Hellerup, Denmark.
authors.forename: Anne-Marie Schjerning
authors.initials: AM
authors.lastname: Olsen
authors.affiliation: National Institute of Public Health, University of Southern Denmark, Odense, Denmark.
authors.forename: Knud
authors.initials: K
authors.lastname: Juel
authors.affiliation: Odense University Hospital, University of Southern Denmark, Odense, Denmark.
authors.forename: Poul Erik
authors.initials: PE
authors.lastname: Mortensen
authors.affiliation: Department of Cardiology, The Heart Center, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
authors.forename: Erik
authors.initials: E
authors.lastname: Jørgensen
authors.affiliation: Department of Cardiology, Aalborg University Hospital, Aalborg, Denmark.
authors.forename: Hans-Henrik
authors.initials: HH
authors.lastname: Tilsted
authors.affiliation: National Institute of Public Health, University of Southern Denmark, Odense, Denmark.
authors.forename: Lene Mia
authors.initials: LM
authors.lastname: von Kappelgaard
authors.affiliation: Department of Health Science and Technology, Aalborg University, Aalborg, Denmark.
authors.forename: Christian
authors.initials: C
authors.lastname: Torp-Pedersen
authors.affiliation: The Cardiovascular Research Center, Gentofte University Hospital, Hellerup, Denmark National Institute of Public Health, University of Southern Denmark, Odense, Denmark.
authors.forename: Gunnar H
authors.initials: GH
authors.lastname: Gislason
mesh_terms: D000328:Adult; D000368:Aged; D002317:Cardiovascular Agents / Q000627:therapeutic use*; D002561:Cerebrovascular Disorders / Q000453:epidemiology*; D015897:Comorbidity / Q000639:trends; D017023:Coronary Angiography; D003327:Coronary Disease / Q000175:diagnosis* / Q000188:drug therapy / Q000453:epidemiology; D003718:Denmark / Q000453:epidemiology; D005500:Follow-Up Studies; D005544:Forecasting; D006333:Heart Failure / Q000453:epidemiology*; D006801:Humans; D008875:Middle Aged; D011159:Population Surveillance; D012189:Retrospective Studies
chemical_list: D002317:Cardiovascular Agents
keywords: Cardiovascular imaging; Coronary angiography; Pharmacoepidemiology; Temporal trends