title: The C-reactive protein level after total knee arthroplasty is gender specific.
abstract: Laboratory diagnostics are part of the routine before and after operations. In all specialist surgical disciplines, including orthopaedic surgery, the acute-phase protein CRP is used to detect inflammatory processes, especially infections. The potential influence of patient gender on the postoperative course of CRP after TKA implantation is still unclear. In order to achieve a more precise evaluation of the complication-free general CRP course after TKA, the objective of the present study is to test the hypothesis that the p.o. course and level of CRP is gender specific in the first 10 days after TKA.
  
  
  
  A total of 1068 consecutive patients who had been treated with a unilateral primary cemented total knee replacement due to primary osteoarthritis of the knee over a 36-month period were retrospectively included in the study. For all patients, the preoperative CRP value and the postoperative course of CRP from postoperative days 1-10 were recorded and tested for gender specificity.
  
  
  
  On days 2-5 and 7-8 after surgery, men had significantly higher CRP values than women. The maximum difference was 45 mg/L on the fourth p.o. day (men 170 mg/L, women 125 mg/L, p = 0.019).
  
  
  
  The present study was able to show, for the first time, that the complication-free course of CRP in the first 10 days after TKA implantation is gender specific. The impact of the finding on diagnostic is that the gender-specific CRP course provides a more precise evaluation of the complication-free course of CRP after TKA. These results have clinical relevance to the interpretation of postoperative CRP values in order to avoid unnecessary investigations such as puncture or surgical care in female and male patients with uncomplicated TKA. Level of evidence Diagnostic study, III.
authors.affiliation: Orthopaedic Department, Jena University Hospital, Campus Eisenberg, Klosterlausnitzer Straße 81, 07607 Eisenberg, Germany. c.windisch@krankenhaus-eisenberg.de.
authors.forename: Christoph
authors.identifier: 0000-0002-0686-020X
authors.initials: C
authors.lastname: Windisch
authors.affiliation: Orthopaedic Department, Friedrich-Schiller University Jena, Campus Eisenberg, Klosterlausnitzer Straße 81, 07607, Eisenberg, Germany.
authors.forename: Steffen
authors.initials: S
authors.lastname: Brodt
authors.affiliation: Orthopaedic Department, Friedrich-Schiller University Jena, Campus Eisenberg, Klosterlausnitzer Straße 81, 07607, Eisenberg, Germany.
authors.forename: Eric
authors.initials: E
authors.lastname: Roehner
authors.affiliation: Orthopaedic Department, Friedrich-Schiller University Jena, Campus Eisenberg, Klosterlausnitzer Straße 81, 07607, Eisenberg, Germany.
authors.forename: Georg
authors.initials: G
authors.lastname: Matziolis
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D019645:Arthroplasty, Replacement, Knee; D002097:C-Reactive Protein / Q000032:analysis*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D020370:Osteoarthritis, Knee / Q000601:surgery; D011184:Postoperative Period; D012189:Retrospective Studies; D012737:Sex Factors
chemical_list: D002097:C-Reactive Protein
keywords: C-reactive protein (CRP); Gender; Osteoarthritis; Total knee arthroplasty (TKA)