title: Continuous spinal labor analgesia for two deliveries in a parturient with severe subvalvular aortic stenosis.
abstract: Various degrees of left ventricular outflow tract (LVOT) obstruction have been seen in patients with subvalvular aortic stenosis (SAS). Regional analgesia during labor for parturients with SAS is relatively contraindicated because it has a potential risk for hemodynamic instability due to sympathetic blockade as a result of vasodilation by local anesthetics. We thought continuous spinal analgesia (CSA) using an opioid and minimal doses of local anesthetic could provide more stable hemodynamic status. We demonstrate the management of a 28-year-old pregnant patient with SAS who received CSA for her two deliveries. For her first delivery (peak pressure gradient (∆P) between LV and aorta was approximately 55 mmHg), intrathecal fentanyl was used as a basal infusion, but we needed a small amount of bupivacaine to provide supplemental intrathecal analgesia as labor progressed. Although there were mild fluctuations in hemodynamics, she was asymptomatic. For her second delivery (∆P between LV and aorta was approximately 90 mmHg), minimal doses of continuous bupivacaine were used as a basal infusion. For her additional analgesic requests, bolus co-administration of fentanyl was effective. There were no fluctuations in her hemodynamics. Although her SAS in her second pregnancy was more severe than in the first, her hemodynamics exhibited less fluctuation during the second delivery with this method. In conclusion, CSA using fentanyl combined with minimal doses of bupivacaine provided satisfactory analgesia and stable hemodynamics in parturient with severe SAS.
authors.affiliation: Division of Obstetric Anesthesia, Center for Perinatal Care, Child Health and Development, Kitasato University Hospital, 1-15-1 Kitasato Minami-ku, Sagamihara City, Kanagawa, 252-0375, Japan.
authors.forename: Shunsuke
authors.initials: S
authors.lastname: Hyuga
authors.affiliation: Division of Obstetric Anesthesia, Center for Perinatal Care, Child Health and Development, Kitasato University Hospital, 1-15-1 Kitasato Minami-ku, Sagamihara City, Kanagawa, 252-0375, Japan. tokutomi@kitasato-u.ac.jp.
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Okutomi
authors.affiliation: Division of Obstetric Anesthesia, Center for Perinatal Care, Child Health and Development, Kitasato University Hospital, 1-15-1 Kitasato Minami-ku, Sagamihara City, Kanagawa, 252-0375, Japan.
authors.forename: Rie
authors.initials: R
authors.lastname: Kato
authors.affiliation: Division of Obstetric Anesthesia, Center for Perinatal Care, Child Health and Development, Kitasato University Hospital, 1-15-1 Kitasato Minami-ku, Sagamihara City, Kanagawa, 252-0375, Japan.
authors.forename: Yuki
authors.initials: Y
authors.lastname: Hosokawa
mesh_terms: D016362:Analgesia, Obstetrical / Q000379:methods*; D000701:Analgesics, Opioid / Q000008:administration & dosage; D000779:Anesthetics, Local / Q000008:administration & dosage; D001020:Aortic Stenosis, Subvalvular / Q000503:physiopathology*; D002045:Bupivacaine / Q000008:administration & dosage*; D036861:Delivery, Obstetric; D005260:Female; D005283:Fentanyl / Q000008:administration & dosage*; D006439:Hemodynamics; D006801:Humans; D007743:Labor, Obstetric; D011247:Pregnancy
chemical_list: D000701:Analgesics, Opioid; D000779:Anesthetics, Local; D005283:Fentanyl; D002045:Bupivacaine
keywords: Continuous spinal analgesia; Labor analgesia; Subvalvular aortic stenosis