title: Cutaneous mantle cell lymphoma: a clinicopathologic review of 10 cases.
abstract: Cutaneous mantle cell lymphoma (MCL) is exceedingly rare, almost always occurring as a dissemination of systemic MCL. To date, only 32 cases have been described. We report a series of 10 cases of MCL in the skin, and provide a comprehensive clinicopathologic review with clinical follow-up. Our cases occurred in older individuals (mean age = 70) and were more frequently in men (90%). Half of them presented in the head and neck region as a mass/nodule, and the remainder in the trunk and extremities as nodules. All patients have stage IV disease. In two of the 10 cases (20%) the cutaneous lesions preceded the diagnosis of disseminated disease. In two of the seven cases with available clinical follow-up information (33%) the skin was immediately involved after the diagnosis of MCL, and in three of the seven the skin was the first site of recurrence (mean interval = 57 months). The mean time to recurrence of the disease was 45.4 months and the overall survival was 66.3 months. Histologically six out of 10 cases (60%) had either pleomorphic or blastoid morphology (four out of 10 and two out of 10, respectively). The mean number of mitoses per 10 high-power fields was 18.44. While nine out of 10 cases expressed cyclin-D1, one case was not positive for cyclin-D1 but did label with SOX-11. Limited cytogenetic data showed trisomy 14 in one case, in addition to the t(11;14) translocation.
authors.affiliation: Department of Pathology, Divisions of Dermatopathology and Hematopathology, University of Virginia, Charlottesville, VA, USA.|Department of Dermatology, Divisions of Dermatopathology and Hematopathology, University of Virginia, Charlottesville, VA, USA.
authors.forename: Alejandro A
authors.initials: AA
authors.lastname: Gru
authors.affiliation: Department of Dermatology, Saint Louis University, St. Louis, MO, USA.
authors.forename: M Yadira
authors.initials: MY
authors.lastname: Hurley
authors.affiliation: Department of Radiation Oncology, The Ohio State University, Columbus, OH, USA.
authors.forename: Andrea L
authors.initials: AL
authors.lastname: Salavaggione
authors.affiliation: Department of Dermatology, University of Rochester, Rochester, NY, USA.
authors.forename: Lindsey
authors.initials: L
authors.lastname: Brodell
authors.affiliation: Department of Internal Medicine, Division of Dermatology, Washington University, School of Medicine, St. Louis, MO, USA.
authors.forename: David
authors.initials: D
authors.lastname: Sheinbein
authors.affiliation: Department of Internal Medicine, Division of Dermatology, Washington University, School of Medicine, St. Louis, MO, USA.
authors.forename: Milan
authors.initials: M
authors.lastname: Anadkat
authors.affiliation: Division of Hematology, The Ohio State Wexner Medical Center, Columbus, OH, USA.
authors.forename: Pierluigi
authors.initials: P
authors.lastname: Porcu
authors.affiliation: Department of Pathology & Immunology, Hematopathology Section, Washington University, St. Louis, MO, USA.
authors.forename: John L
authors.initials: JL
authors.lastname: Frater
mesh_terms: D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D020522:Lymphoma, Mantle-Cell / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000473:pathology; D012878:Skin Neoplasms / Q000473:pathology*
chemical_list: D014408:Biomarkers, Tumor
keywords: mantle cell lymphoma; non-Hodgkin lymphoma; skin tumors