title: Analysis of Cyclin-Dependent Kinase Inhibitor-2B rs1063192 Polymorphism in Saudi Patients with Primary Open-Angle Glaucoma.
abstract: OBJECTIVE
  To investigate whether the polymorphism rs1063192 (A>G) in the cyclin-dependent kinase Inhibitor-2B (CDKN2B) gene is a risk factor for primary open-angle glaucoma (POAG).
  
  
  METHODS
  A case-control study was conducted wherein we genotyped 87 unrelated POAG cases and 94 control subjects from Saudi Arabia using the Taq-Man®assay.
  
  
  RESULTS
  The minor allele frequency was 0.20 in POAG cases and 0.21 in controls. Both the genotype and allele frequencies were not significantly different between cases and controls. No significant association was found between genotypes and glaucoma clinical indices, except that the mutant homozygous genotype (G/G) was associated with the family history of glaucoma (p = 0.024).
  
  
  CONCLUSIONS
  Polymorphism rs1063192 in CDKN2B is not a risk factor for POAG in Saudi cohort.
authors.affiliation: 1 Glaucoma Research Chair, Department of Ophthalmology, College of Medicine, King Saud University , Riyadh, Saudi Arabia .|2 Department of Ophthalmology, College of Medicine, University of Florida , Jacksonville, Florida.
authors.forename: Khaled K
authors.initials: KK
authors.lastname: Abu-Amero
authors.affiliation: 1 Glaucoma Research Chair, Department of Ophthalmology, College of Medicine, King Saud University , Riyadh, Saudi Arabia .
authors.forename: Altaf A
authors.initials: AA
authors.lastname: Kondkar
authors.affiliation: 1 Glaucoma Research Chair, Department of Ophthalmology, College of Medicine, King Saud University , Riyadh, Saudi Arabia .
authors.forename: Ahmed
authors.initials: A
authors.lastname: Mousa
authors.affiliation: 1 Glaucoma Research Chair, Department of Ophthalmology, College of Medicine, King Saud University , Riyadh, Saudi Arabia .
authors.forename: Faisal A
authors.initials: FA
authors.lastname: Almobarak
authors.affiliation: 3 National Center for Stem Cell Technology (NCSCT), Life Sciences and Environmental Research Institute , King Abdulaziz City for Science and Technology (KACST), Riyadh, Saudi Arabia .
authors.forename: Abdullah
authors.initials: A
authors.lastname: Alawad
authors.affiliation: 4 Clinical Research Laboratory, SAAD Research and Development Center, SAAD Specialist Hospital , Al Khobar, Saudi Arabia .|5 Veterinary College, Qassim University , Qassim, Saudi Arabia .
authors.forename: Saleh
authors.initials: S
authors.lastname: Altuwaijri
authors.affiliation: 1 Glaucoma Research Chair, Department of Ophthalmology, College of Medicine, King Saud University , Riyadh, Saudi Arabia .
authors.forename: Tahira
authors.initials: T
authors.lastname: Sultan
authors.affiliation: 1 Glaucoma Research Chair, Department of Ophthalmology, College of Medicine, King Saud University , Riyadh, Saudi Arabia .
authors.forename: Taif A
authors.initials: TA
authors.lastname: Azad
authors.affiliation: 1 Glaucoma Research Chair, Department of Ophthalmology, College of Medicine, King Saud University , Riyadh, Saudi Arabia .
authors.forename: Saleh A
authors.initials: SA
authors.lastname: Al-Obeidan
mesh_terms: D000368:Aged; D000483:Alleles; D015331:Cohort Studies; D050762:Cyclin-Dependent Kinase Inhibitor p15 / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D005902:Glaucoma, Open-Angle / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D012529:Saudi Arabia
chemical_list: C493966:CDKN2B protein, human; D050762:Cyclin-Dependent Kinase Inhibitor p15
keywords: CDKN2B; Saudi Arabia; genetics; primary open angle glaucoma; rs1063192