title: Primary Cutaneous Gamma-Delta (γ/δ) T-cell Lymphoma: An Unusual Case With Very Subtle Histopathological Findings.
abstract: Primary cutaneous γ/δ T-cell lymphoma (PCGDTCL) accounts for <1% of all primary cutaneous lymphomas. These rare diseases are believed to originate from γ/δ lymphocytes. Clinical presentation may vary, but its clinical behavior is regarded as aggressive and long-term survival is anecdotal. This study describes the case of a 60-year-old man with multiple, rapidly progressing skin plaques on his head, arms, torso, buttocks, and legs. The histopathological changes seen in the skin biopsy were extraordinarily subtle with mild epidermal hyperplasia and a very sparse lymphoid infiltrate involving epidermis and superficial dermis. Immunohistochemical studies revealed the atypical intraepidermal hyperchromatic cells to be mostly positive for CD3 and CD7 and negative for both CD4 and CD8. The intraepidermal atypical lymphocytes were positive for TCR gamma, and negative for betaF1 and CD56. The clinical, morphologic, and immunohistochemical findings supported the diagnosis of PCGDTCL. This case illustrates a case of epidermotropic variant of PCGDTCL that, albeit a bland histopathological presentation, was associated with an aggressive clinical behavior.
authors.affiliation: *Department of Pathology, SUNY Upstate Medical University, Syracuse, NY; †Department of Pathology, Dermatopathology Section, The University of Texas MD Anderson Cancer Center, Houston, TX; Departments of ‡Dermatology, and §Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX.
authors.forename: Nisha S
authors.initials: NS
authors.lastname: Ramani
authors.forename: Jonathan L
authors.initials: JL
authors.lastname: Curry
authors.forename: E Dean
authors.initials: ED
authors.lastname: Merrill
authors.forename: Phyu P
authors.initials: PP
authors.lastname: Aung
authors.forename: Victor
authors.initials: V
authors.lastname: Prieto
authors.forename: Michael T
authors.initials: MT
authors.lastname: Tetzlaff
authors.forename: Madeleine
authors.initials: M
authors.lastname: Duvic
authors.forename: Roberto N
authors.initials: RN
authors.lastname: Miranda
authors.forename: Carlos
authors.initials: C
authors.lastname: Torres-Cabala
mesh_terms: D014408:Biomarkers, Tumor / Q000032:analysis*; D001706:Biopsy; D006801:Humans; D007150:Immunohistochemistry; D016130:Immunophenotyping; D016410:Lymphoma, T-Cell, Cutaneous / Q000276:immunology / Q000473:pathology* / Q000628:therapy; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D011237:Predictive Value of Tests; D016692:Receptors, Antigen, T-Cell, gamma-delta / Q000032:analysis*; D012878:Skin Neoplasms / Q000276:immunology / Q000473:pathology* / Q000628:therapy
chemical_list: D014408:Biomarkers, Tumor; D016692:Receptors, Antigen, T-Cell, gamma-delta