title: Population dynamics of Anopheles nuneztovari in Colombia.
abstract: Anopheles nuneztovari is an important Colombian malaria vector widespread on both sides of the Andean Mountains, presenting morphological, behavioral and genetic heterogeneity throughout the country. The aim of this study was to evaluate whether the population structure and distribution of An. nuneztovari in Colombia are associated with ecological and physical barriers present in a heterogeneous landscape. Further, differences in behavior were addressed. A total of 5392 specimens of An. nuneztovari were collected. Mitochondrial and nuclear marker analyses detected subdivision among the northwest-west, northeast and east populations. For both markers, isolation by distance (~53%) and isolation by resistance (>30%) were determinants of population genetic differentiation. This suggests that physical barriers, geographical distance and ecological differences on both sides of the Andean Mountains promoted the genetic differentiation and population subdivision of An. nuneztovari in Colombia. This species showed the highest biting activity after 20:00h; indoor and outdoor preferences were found in all localities. These results indicated that the most effective interventions for controlling vector populations on both sides of the Andes need to be region-specific.
authors.affiliation: Grupo de Microbiología Molecular, Escuela de Microbiología, Universidad de Antioquia, Calle 70 No. 52-21, Medellín, Colombia. Electronic address: jezzid4@gmail.com.
authors.forename: Nelson
authors.initials: N
authors.lastname: Naranjo-Díaz
authors.affiliation: Departamento de Epidemiologia, Faculdade de Saúde Pública, Universidade de São Paulo, São Paulo, Brazil. Electronic address: masallum@usp.br.
authors.forename: Maria Anice M
authors.initials: MAM
authors.lastname: Sallum
authors.affiliation: Grupo de Microbiología Molecular, Escuela de Microbiología, Universidad de Antioquia, Calle 70 No. 52-21, Medellín, Colombia. Electronic address: margaritcorrea@gmail.com.
authors.forename: Margarita M
authors.initials: MM
authors.lastname: Correa
mesh_terms: D000818:Animals; D000852:Anopheles / Q000235:genetics* / Q000502:physiology*; D001522:Behavior, Animal / Q000502:physiology; D003105:Colombia; D004351:Drug Resistance; D017753:Ecosystem; D005260:Female; D005828:Genetics, Population; D058974:Phylogeography; D011157:Population Dynamics
keywords: Anopheles nuneztovari; Biting activity; Colombia; Isolation by distance; Isolation by resistance; Population structure