title: Poly(γ-glutamic acid), coagulation? Anticoagulation?
abstract: Poly(γ-glutamic acid) (γ-PGA) powder was usually used as hemostatic agent because of its excellent physical properties of water-absorption and water-locking. However, if γ-PGA absorbs enough water, how about its blood compatibility? Here, the other side of the coin was investigated. The anticoagulant properties of γ-PGA were characterized by in vitro coagulation tests, hemolytic assay, platelet adhesion, and platelet activation. Moreover, cytotoxicity experiments of γ-PGA were also carried out by MTT assay. Results indicated that the sufficient water-absorbed γ-PGA has good anticoagulant property and non-cytotoxicity. It means γ-PGA has good anticoagulant property, non-cytotoxicity. If γ-PGA has absorbed enough water, it can be used as an anticoagulation biomaterial. With double effects (coagulation and anticoagulation), the γ-PGA with desirable bioproperties can be readily tailored to cater to various biomedical applications.
authors.affiliation: a State Key Laboratory of Materials-Oriented Chemical Engineering , College of Food Science and Light Industry, Nanjing Tech University , Nanjing , China.|b Jiangsu Key Laboratory of Biofunctional Materials, School of Chemistry and Materials Science , National and Local Joint Engineering Research Center of Biomedical Functional Materials, Nanjing Normal University , Nanjing , China.
authors.forename: Tingting
authors.initials: T
authors.lastname: Xu
authors.affiliation: b Jiangsu Key Laboratory of Biofunctional Materials, School of Chemistry and Materials Science , National and Local Joint Engineering Research Center of Biomedical Functional Materials, Nanjing Normal University , Nanjing , China.
authors.forename: Fang
authors.initials: F
authors.lastname: Peng
authors.affiliation: b Jiangsu Key Laboratory of Biofunctional Materials, School of Chemistry and Materials Science , National and Local Joint Engineering Research Center of Biomedical Functional Materials, Nanjing Normal University , Nanjing , China.
authors.forename: Tao
authors.initials: T
authors.lastname: Zhang
authors.affiliation: a State Key Laboratory of Materials-Oriented Chemical Engineering , College of Food Science and Light Industry, Nanjing Tech University , Nanjing , China.
authors.forename: Bo
authors.initials: B
authors.lastname: Chi
authors.affiliation: a State Key Laboratory of Materials-Oriented Chemical Engineering , College of Food Science and Light Industry, Nanjing Tech University , Nanjing , China.
authors.forename: Hong
authors.initials: H
authors.lastname: Xu
authors.affiliation: b Jiangsu Key Laboratory of Biofunctional Materials, School of Chemistry and Materials Science , National and Local Joint Engineering Research Center of Biomedical Functional Materials, Nanjing Normal University , Nanjing , China.
authors.forename: Chun
authors.initials: C
authors.lastname: Mao
authors.affiliation: b Jiangsu Key Laboratory of Biofunctional Materials, School of Chemistry and Materials Science , National and Local Joint Engineering Research Center of Biomedical Functional Materials, Nanjing Normal University , Nanjing , China.
authors.forename: Shuaihui
authors.initials: S
authors.lastname: Feng
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000494:pharmacology*; D001777:Blood Coagulation / Q000187:drug effects*; D006461:Hemolysis / Q000187:drug effects; D015539:Platelet Activation / Q000187:drug effects; D010973:Platelet Adhesiveness / Q000187:drug effects; D011099:Polyglutamic Acid / Q000031:analogs & derivatives* / Q000494:pharmacology; D011817:Rabbits
chemical_list: D001672:Biocompatible Materials; C511775:poly(gamma-glutamic acid); D011099:Polyglutamic Acid
keywords: Poly(γ-glutamic acid); anticoagulation; coagulation; cytotoxicity; water-absorption