title: Pediatric Sarcomas.
abstract: Pediatric sarcomas are a heterogeneous group of tumors accounting for approximately 10% of childhood solid tumors. Treatment is focused on multimodality therapy, which has improved the prognosis over the past two decades. Current regimens focus on decreasing treatment for low-risk patients to decrease the long-term side effects while maximizing therapy for patients with metastatic disease to improve survival. Pediatric sarcomas can be divided into soft tissue sarcomas and osseous tumors. Soft tissue sarcomas are further delineated into rhabdomyosarcomas, which affect young children and nonrhabdomyosarcomas, which are most common in adolescents. The most common bone sarcomas are osteosarcomas and Ewing's sarcoma.
authors.affiliation: Department of Surgery, University of Tennessee Health Science Center, 49 North Dunlap Avenue, Second Floor, Memphis, TN 38105, USA. Electronic address: rfwillia@uthsc.edu.
authors.forename: Regan F
authors.initials: RF
authors.lastname: Williams
authors.affiliation: Department of Surgery, St Jude Children's Research Hospital, MS133, Room B3019, 262 Danny Thomas Place, Memphis, TN 38105-3678, USA.
authors.forename: Israel
authors.initials: I
authors.lastname: Fernandez-Pineda
authors.affiliation: Department of Surgery, University of Tennessee Health Science Center, 49 North Dunlap Avenue, Second Floor, Memphis, TN 38105, USA.
authors.forename: Ankush
authors.initials: A
authors.lastname: Gosain
mesh_terms: D002648:Child; D003131:Combined Modality Therapy; D019468:Disease Management; D006801:Humans; D012509:Sarcoma / Q000628:therapy*
keywords: Ewing’s sarcoma; Nonrhabdomyosarcoma soft tissue sarcoma; Osteosarcoma; Rhabdomyosarcoma