title: Two New Oleanane-type Triterpenoids from Methanolyzed Saponins of Momordica cochinchinensis.
abstract: Two new oleanane-type triterpenoid saponins (1 and 2) were isolated from the methanolyzed total saponins of the seeds of Momordica cochinchinensis (Lour.) Spreng, together with 16 known compounds (3-18). Their structures were elucidated on the basis of detailed spectroscopic, including 1D and 2D NMR, mass spectrometric, methanolysis and LC-MS analysis. All the isolates were tested for their cytotoxic activities against five human cancer cell lines (HL-60, SMMC-7721, PANC-1, A-549, and SW-480) and the glucose uptake activity. The known compound 6 exhibited toxic effects against HL-60 with an IC50 value of 18.1 μM, while 10 showed cytotoxicity against SMMC-7721 and A-549 cell lines, with IC50 values of 34.4 and 32.8 μM, respectively. In addition, the new compound 2 showed glucose uptake activity with a glucose consumption value of 0.29 μM at 10 μM concentration.
authors.forename: Rong
authors.initials: R
authors.lastname: Fan
authors.forename: Rong-Rong
authors.initials: RR
authors.lastname: Cheng
authors.forename: Hong-Tao
authors.initials: HT
authors.lastname: Zhu
authors.forename: Dong
authors.initials: D
authors.lastname: Wang
authors.forename: Chong-Ren
authors.initials: CR
authors.lastname: Yang
authors.forename: Min
authors.initials: M
authors.lastname: Xua
authors.forename: Ying-Jun
authors.initials: YJ
authors.lastname: Zhang
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D015394:Molecular Structure; D029775:Momordica / Q000737:chemistry*; D009828:Oleanolic Acid / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology; D012503:Saponins / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D004365:Drugs, Chinese Herbal; D012503:Saponins; C413246:oleanane; D009828:Oleanolic Acid