title: Synthesis and evaluation of multifunctional ferulic and caffeic acid dimers for Alzheimer's disease.
abstract: In this study, a series of novel ferulic and caffeic acid dimers was designed and synthesised, and their multifunctional properties against Alzheimer's disease (AD) were evaluated. Results showed that our multifunctional strategy was great supported by enhancing the inhibition of Aβ1-42self-induced aggregation. Moreover, 7b also had potent protective effects against glutamate-induced cell death without significant cell toxicity in mouse hippocampal neuronal HT22 cells and 10c effectively scavenged diphenylpicrylhydrazyl free radicals. Collectively, these data strongly encourage further optimisation of 7b as a new hit to develop multifunctional agents for the treatment of AD.
authors.affiliation: a College of Chinese Materia Media , Guangzhou University of Chinese Medicine , Guangzhou , China.
authors.forename: Xi-Xin
authors.initials: XX
authors.lastname: He
authors.affiliation: b Department of Pharmacology, School of Pharmaceutical Sciences , Sun Yat-Sen University , Guangzhou , China.|c International Joint Laboratory (SYSU-PolyU HK) of Novel Anti-dementia Drugs of Guangdong , Guangzhou , China.
authors.forename: Xiao-Hong
authors.initials: XH
authors.lastname: Yang
authors.affiliation: a College of Chinese Materia Media , Guangzhou University of Chinese Medicine , Guangzhou , China.
authors.forename: Rui-Ying
authors.initials: RY
authors.lastname: Ou
authors.affiliation: d Department of Pediatrics , Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University , Guangzhou , China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Ouyang
authors.affiliation: b Department of Pharmacology, School of Pharmaceutical Sciences , Sun Yat-Sen University , Guangzhou , China.|c International Joint Laboratory (SYSU-PolyU HK) of Novel Anti-dementia Drugs of Guangdong , Guangzhou , China.
authors.forename: Sheng-Nan
authors.initials: SN
authors.lastname: Wang
authors.affiliation: b Department of Pharmacology, School of Pharmaceutical Sciences , Sun Yat-Sen University , Guangzhou , China.|c International Joint Laboratory (SYSU-PolyU HK) of Novel Anti-dementia Drugs of Guangdong , Guangzhou , China.
authors.forename: Zi-Wei
authors.initials: ZW
authors.lastname: Chen
authors.affiliation: b Department of Pharmacology, School of Pharmaceutical Sciences , Sun Yat-Sen University , Guangzhou , China.|c International Joint Laboratory (SYSU-PolyU HK) of Novel Anti-dementia Drugs of Guangdong , Guangzhou , China.
authors.forename: Shi-Jun
authors.initials: SJ
authors.lastname: Wen
authors.affiliation: b Department of Pharmacology, School of Pharmaceutical Sciences , Sun Yat-Sen University , Guangzhou , China.|c International Joint Laboratory (SYSU-PolyU HK) of Novel Anti-dementia Drugs of Guangdong , Guangzhou , China.
authors.forename: Rong-Biao
authors.initials: RB
authors.lastname: Pi
mesh_terms: D000544:Alzheimer Disease / Q000188:drug therapy*; D016229:Amyloid beta-Peptides / Q000037:antagonists & inhibitors; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology; D001713:Biphenyl Compounds / Q000737:chemistry; D002109:Caffeic Acids / Q000138:chemical synthesis* / Q000627:therapeutic use*; D016923:Cell Death / Q000187:drug effects; D002460:Cell Line; D003373:Coumaric Acids / Q000138:chemical synthesis* / Q000627:therapeutic use*; D016166:Free Radical Scavengers / Q000737:chemistry / Q000494:pharmacology; D018698:Glutamic Acid / Q000633:toxicity; D006801:Humans; D051379:Mice; D009474:Neurons / Q000187:drug effects; D010446:Peptide Fragments / Q000037:antagonists & inhibitors; D010851:Picrates / Q000737:chemistry
chemical_list: D016229:Amyloid beta-Peptides; D000975:Antioxidants; D001713:Biphenyl Compounds; D002109:Caffeic Acids; D003373:Coumaric Acids; D016166:Free Radical Scavengers; D010446:Peptide Fragments; D010851:Picrates; C075222:amyloid beta-protein (1-42); D018698:Glutamic Acid; C004999:ferulic acid; C004931:1,1-diphenyl-2-picrylhydrazyl; C040048:caffeic acid
keywords: Ferulic acid; aggregation; amyloid protein; caffeic acid; free radicals; multifunctional neuroprotective agents