title: The Role for Radiation Therapy in the Management of Sarcoma.
abstract: Although there is no consensus regarding the optimal sequencing of external beam radiotherapy and surgery for extremity soft tissue sarcoma, radiation therapy delivered before or after limb-sparing surgery significantly improves local control, particularly for high-grade tumors. Large database analyses suggest that improved local control may translate into an overall survival benefit. Best practices require ample communication between the radiation and surgical teams to ensure appropriate tissues are targeted, unnecessary radiation is avoided, and patients are afforded the best opportunity for cure while maintaining function. Modern experiences with intensity-modulated radiotherapy/image-guided radiation therapy suggest toxicity is reduced through field size reduction and precise targeting, improving the therapeutic ratio.
authors.affiliation: Department of Radiation Oncology, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA.
authors.forename: Brooke K
authors.initials: BK
authors.lastname: Leachman
authors.affiliation: Department of Radiation Oncology, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA. Electronic address: Thomas.Galloway@fccc.edu.
authors.forename: Thomas J
authors.initials: TJ
authors.lastname: Galloway
mesh_terms: D019468:Disease Management; D006801:Humans; D018714:Radiotherapy, Adjuvant; D050397:Radiotherapy, Intensity-Modulated / Q000379:methods*; D012509:Sarcoma / Q000532:radiotherapy*
keywords: External beam radiation therapy; IGRT; IMRT; Preoperative versus postoperative radiation; Radiation treatment planning