title: The Impact of Angiotensin-Modulating Antihypertensives on Time Interval to Revision Surgery for Nasal Polyps.
abstract: Angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs) have been shown to suppress expression of periostin, a matricellular protein that is markedly elevated in nasal polyp tissue. The purpose of this study was to determine whether use of these antihypertensive agents affects the time to revision sinus surgery in patients with polyp regrowth.
  
  
  
  Case series with chart review.
  
  
  
  Academic medical center.
  
  
  
  Records were reviewed for 330 patients who underwent ≥2 operations for chronic sinusitis with nasal polyps from April 1987 through August 2015. The time between surgical interventions was compared with patient demographics and clinical characteristics, including use of ACEIs and ARBs.
  
  
  
  Sixty patients were taking ACEIs or ARBs during the study period, of which 32 had concurrent asthma. The mean interval between polyp operations was 61.0 ± 45.2 months (range, 2-228.6 months). Among patients with asthma (n = 197), the mean time to revision surgery was prolonged by >2 years for those taking ACEIs or ARBs (81.0 vs 54.5 months, P = .006). A similar impact on time to revision surgery was not observed for nonasthmatics taking these medications (61.0 vs 65.2 months, P = .655).
  
  
  
  Use of ACEIs and ARBs is associated with an increased time to revision sinus surgery among patients with concurrent nasal polyps and asthma. A possible mechanism of this observed effect is suppression of periostin expression through inhibition of the angiotensin pathway.
authors.affiliation: Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, USA chris.brook@bmc.org.|Department of Otolaryngology, Harvard Medical School, Boston, Massachusetts, USA.
authors.forename: Christopher D
authors.initials: CD
authors.lastname: Brook
authors.affiliation: Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, USA.|Department of Otolaryngology, Harvard Medical School, Boston, Massachusetts, USA.
authors.forename: Alice Z
authors.initials: AZ
authors.lastname: Maxfield
authors.affiliation: Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, USA.|Department of Otolaryngology, Harvard Medical School, Boston, Massachusetts, USA.
authors.forename: Konstantina
authors.initials: K
authors.lastname: Stankovic
authors.affiliation: Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, USA.|Department of Otolaryngology, Harvard Medical School, Boston, Massachusetts, USA.
authors.forename: Ralph B
authors.initials: RB
authors.lastname: Metson
mesh_terms: D000046:Academic Medical Centers; D057911:Angiotensin Receptor Antagonists / Q000627:therapeutic use*; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000627:therapeutic use*; D001249:Asthma / Q000150:complications; D015815:Cell Adhesion Molecules / Q000187:drug effects; D002908:Chronic Disease; D005260:Female; D006801:Humans; D007828:Laryngoscopy; D008297:Male; D008875:Middle Aged; D009298:Nasal Polyps / Q000150:complications / Q000188:drug therapy* / Q000401:mortality / Q000601:surgery*; D012189:Retrospective Studies; D012220:Rhinitis / Q000188:drug therapy; D012307:Risk Factors; D012852:Sinusitis / Q000188:drug therapy; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D057911:Angiotensin Receptor Antagonists; D000806:Angiotensin-Converting Enzyme Inhibitors; D015815:Cell Adhesion Molecules; C512835:POSTN protein, human
keywords: angiotensin converting enzyme inhibitor; angiotensin receptor blocker; asthma; chronic rhinosinusitis; endoscopic sinus surgery; nasal polyps; periostin