title: Next Generation Multiresponsive Nanocarriers for Targeted Drug Delivery to Cancer Cells.
abstract: C-H bond activation of 2-methoxyethylamino-bis(phenolate)-yttrium catalysts allowed the synthesis of BAB block copolymers comprised of 2-vinylpyridine (2VP; monomer A) and diethylvinylphosphonate (DEVP; monomer B) as the A and B blocks, respectively, by rare-earth-metal-mediated group-transfer polymerization (REM-GTP). The inherent multi-stimuli-responsive character and drug-loading and -release capabilities were observed to be dependent on the chain length and monomer ratios. Cytotoxicity assays revealed the biocompatibility and nontoxic nature of the obtained micelles toward ovarian cancer (HeLa) cells. The BAB block copolymers effectively encapsulated, transported, and released doxorubicin (DOX) within HeLa cells. REM-GTP enables access to previously unattainable vinylphosphonate copolymer structures, and thereby unlocks their full potential as nanocarriers for stimuli-responsive drug delivery in HeLa cells. The self-evident consequence is the application of these new micelles as potent drug-delivery vehicles with reduced side effects in future cancer therapies.
authors.affiliation: WACKER-Lehrstuhl für Makromolekulare Chemie, Technische Universität München, Lichtenbergstraße 4, 85748, Garching bei München, Germany. peteraltenbuchner@gmail.com.
authors.forename: Peter T
authors.initials: PT
authors.lastname: Altenbuchner
authors.affiliation: WACKER-Lehrstuhl für Makromolekulare Chemie, Technische Universität München, Lichtenbergstraße 4, 85748, Garching bei München, Germany.
authors.forename: Patrick D L
authors.initials: PD
authors.lastname: Werz
authors.affiliation: Center for Integrated Protein Science Munich (CIPSM) and Lehrstuhl für Biotechnologie, Technische Universität München, Lichtenbergstraße 4, 85748, Garching bei München, Germany.
authors.forename: Patricia
authors.initials: P
authors.lastname: Schöppner
authors.affiliation: WACKER-Lehrstuhl für Makromolekulare Chemie, Technische Universität München, Lichtenbergstraße 4, 85748, Garching bei München, Germany.
authors.forename: Friederike
authors.initials: F
authors.lastname: Adams
authors.affiliation: WACKER-Lehrstuhl für Makromolekulare Chemie, Technische Universität München, Lichtenbergstraße 4, 85748, Garching bei München, Germany.
authors.forename: Alexander
authors.initials: A
authors.lastname: Kronast
authors.affiliation: WACKER-Lehrstuhl für Makromolekulare Chemie, Technische Universität München, Lichtenbergstraße 4, 85748, Garching bei München, Germany.
authors.forename: Christina
authors.initials: C
authors.lastname: Schwarzenböck
authors.affiliation: Department Chemie & Catalysis Research Center, Technische Universität München, Ernst-Otto-Fischer-Straße 1, 85748, Garching bei München, Germany.
authors.forename: Alexander
authors.initials: A
authors.lastname: Pöthig
authors.affiliation: Department Chemie & Catalysis Research Center, Technische Universität München, Ernst-Otto-Fischer-Straße 1, 85748, Garching bei München, Germany.
authors.forename: Christian
authors.initials: C
authors.lastname: Jandl
authors.affiliation: Center for Integrated Protein Science Munich (CIPSM) and Lehrstuhl für Biotechnologie, Technische Universität München, Lichtenbergstraße 4, 85748, Garching bei München, Germany.
authors.forename: Martin
authors.initials: M
authors.lastname: Haslbeck
authors.affiliation: WACKER-Lehrstuhl für Makromolekulare Chemie, Technische Universität München, Lichtenbergstraße 4, 85748, Garching bei München, Germany. rieger@tum.de.
authors.forename: Bernhard
authors.initials: B
authors.lastname: Rieger
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000737:chemistry; D002384:Catalysis; D002470:Cell Survival / Q000187:drug effects; D004317:Doxorubicin / Q000008:administration & dosage / Q000737:chemistry; D004337:Drug Carriers / Q000138:chemical synthesis*; D065546:Drug Liberation; D006367:HeLa Cells; D006801:Humans; D008823:Micelles; D015394:Molecular Structure; D053758:Nanoparticles / Q000737:chemistry*; D010316:Particle Size; D011092:Polyethylene Glycols / Q000737:chemistry; D058105:Polymerization; D013499:Surface Properties; D015019:Yttrium / Q000737:chemistry
chemical_list: D000970:Antineoplastic Agents; D004337:Drug Carriers; D008823:Micelles; D011092:Polyethylene Glycols; D015019:Yttrium; D004317:Doxorubicin
keywords: drug delivery; group-transfer polymerization; micelles; stimuli-responsive release; vinylphosphonates