title: Anti-seizure activity of flower extracts of Nepeta bractaeta in Swiss albino mice.
abstract: Epilepsy is a neurological disorder characterized by unprovoked, recurring seizures that disrupts the nervous system and can cause mental and physical dysfunction. Based on the ethno pharmacological information of the plant, the methanolic and aqueous extracts of the flowers of Nepeta bractaeta was evaluated for its antiepileptic activity. The methanolic and aqueous extracts of the flowers of Nepeta bracteata were observed for their antiepileptic activity by increased current Electroshock seizures (ICES) test and Pentylenetetrazole (PTZ) test using Swiss albino mice. Both the extracts showed significant activity in ICES and PTZ induced convulsions in comparison to control. In ICES model, NBAE at higher dose showed 16.7 % and NBME at higher dose showed 33.3 % protection against seizure and in PTZ model, NBME at higher dose showed 33.3 % protection against seizure. From the experiments performed, it can be said that Nepeta bractaeta does possess anticonvulsant property.
authors.affiliation: Department of Ilmul-Advia, Faculty of Medicine (Unani), Jamia Hamdard, New Delhi, India-110062.
authors.forename: Jalal Uddin
authors.initials: JU
authors.lastname: Bhat
authors.affiliation: Department of Pharmacognosy & Phytochemistry, Faculty of Pharmacy, Jamia Hamdard.
authors.forename: Shabir Ahmad
authors.initials: SA
authors.lastname: Parray
authors.affiliation: Department of Ilmul-Advia, Faculty of Medicine (Unani), Jamia Hamdard, New Delhi, India-110062.
authors.forename: Mohammad
authors.initials: M
authors.lastname: Aslam
authors.affiliation: Department of Pharmacognosy & Phytochemistry, Faculty of Pharmacy, Jamia Hamdard.
authors.forename: Shahid
authors.initials: S
authors.lastname: Ansari
authors.affiliation: Department of Ilmul-Advia, Faculty of Medicine (Unani), Jamia Hamdard, New Delhi, India-110062.
authors.forename: Qudsia
authors.initials: Q
authors.lastname: Nizami
authors.affiliation: Department of Pharmacology, Faculty of Pharmacy, Jamia Hamdard, New Delhi, India-110062.
authors.forename: Razia
authors.initials: R
authors.lastname: Khanam
authors.affiliation: Department of Ilmul-Advia, Faculty of Medicine (Unani), Jamia Hamdard, New Delhi, India-110062.
authors.forename: Aisha
authors.initials: A
authors.lastname: Siddiqui
authors.affiliation: Department of Ilmul-Advia, Faculty of Medicine (Unani), Jamia Hamdard, New Delhi, India-110062.
authors.forename: Mohd Aftab
authors.initials: MA
authors.lastname: Ahmad
keywords: ICES; Nepeta bractaeta; PTZ; antiepileptic effects