title: Advancement in Catalytic Asymmetric Hydrogenation of Ketones and Imines, and Development of Asymmetric Isomerization of Allylic Alcohols.
abstract: Catalytic asymmetric hydrogenation of ketones through the "metal-ligand cooperative mechanism" has been improved in terms of the efficiency, stereoselectivity, and scope of substrates by varying the arrangement of the catalyst structure and reaction conditions. Imino compounds are also smoothly converted to the optically active amines with appropriate catalysts. This type of catalyst exhibits excellent performance on the asymmetric isomerization of primary allylic alcohols into the optically active aldehydes. This personal account describes recent progress on these topics.
authors.affiliation: Division of Applied Chemistry, Faculty of Engineering, Hokkaido University, N13-W8, Kita-ku, Sapporo, Hokkaido, 060-8628, Japan.|Frontier Chemistry Center, Faculty of Engineering, Hokkaido University, N13-W8, Kita-ku, Sapporo, Hokkaido, 060-8628, Japan.
authors.forename: Takeshi
authors.initials: T
authors.lastname: Ohkuma
authors.affiliation: Division of Applied Chemistry, Faculty of Engineering, Hokkaido University, N13-W8, Kita-ku, Sapporo, Hokkaido, 060-8628, Japan.
authors.forename: Noriyoshi
authors.initials: N
authors.lastname: Arai
keywords: asymmetric catalysis; hydrogenation; iridium; isomerization; ruthenium