title: Aflatoxin B1 can be complexed with oxidised tea polyphenols and the absorption of the complexed aflatoxin B1 is inhibited in rats.
abstract: BACKGROUND
  Aflatoxin B1 (AFB1) is the most prevalent and carcinogenic form of the aflatoxins. In this report, we explored the interaction between AFB1 and oxidised tea polyphenols (OTP). Then, the influence of OTP on the absorption and toxicity of AFB1 in rats was investigated.
  
  
  RESULTS
  We found that AFB1 can be complexed with OTP, and a transmembrane bidirectional transport experiment verified the absorption of complexed AFB1 (C-AFB1) was inhibited by OTP dramatically (P < 0.001). Animal experiments results showed that the AFB1 plus OTP group had significantly (P < 0.05) decreased AFB1-albumin (AFB1-alb) compared to the AFB1 group at 4 h after ingestion. OTP could significantly (P < 0.01) promote the elimination of AFB1 in faeces. Moreover, the liver injury induced by AFB1 was significantly inhibited by OTP.
  
  
  CONCLUSIONS
  Our results demonstrated AFB1 can be complexed with OTP and the absorption of the C-AFB1 is inhibited in rats. Consequently, the liver injury induced by AFB1 can be inhibited by OTP. These results provide insight that consuming OTP-containing products, like fermented Pu-er tea, can protect damage from AFB1, and OTP may be used as a kind of food additive. © 2016 Society of Chemical Industry.
authors.affiliation: Key Laboratory of Pu-er Tea Science, Ministry of Education, Yunnan Agricultural University, Kunming, 650201, China.|Tea Research Center of Yunnan, Kunming, 650201, China.|College of Food Science and Technology, Yunnan Agricultural University, Kunming, 650201, China.
authors.forename: Hao
authors.initials: H
authors.lastname: Lu
authors.affiliation: Key Laboratory of Pu-er Tea Science, Ministry of Education, Yunnan Agricultural University, Kunming, 650201, China.|Tea Research Center of Yunnan, Kunming, 650201, China.|College of Food Science and Technology, Yunnan Agricultural University, Kunming, 650201, China.
authors.forename: Feifei
authors.initials: F
authors.lastname: Liu
authors.affiliation: Key Laboratory of Pu-er Tea Science, Ministry of Education, Yunnan Agricultural University, Kunming, 650201, China.|Tea Research Center of Yunnan, Kunming, 650201, China.|College of Food Science and Technology, Yunnan Agricultural University, Kunming, 650201, China.
authors.forename: Qiangqiang
authors.initials: Q
authors.lastname: Zhu
authors.affiliation: Key Laboratory of Pu-er Tea Science, Ministry of Education, Yunnan Agricultural University, Kunming, 650201, China.|Tea Research Center of Yunnan, Kunming, 650201, China.|College of Food Science and Technology, Yunnan Agricultural University, Kunming, 650201, China.
authors.forename: Mengmeng
authors.initials: M
authors.lastname: Zhang
authors.affiliation: Key Laboratory of Pu-er Tea Science, Ministry of Education, Yunnan Agricultural University, Kunming, 650201, China.|Tea Research Center of Yunnan, Kunming, 650201, China.|College of Food Science and Technology, Yunnan Agricultural University, Kunming, 650201, China.
authors.forename: Tong
authors.initials: T
authors.lastname: Li
authors.affiliation: Key Laboratory of Pu-er Tea Science, Ministry of Education, Yunnan Agricultural University, Kunming, 650201, China.|Tea Research Center of Yunnan, Kunming, 650201, China.|College of Food Science and Technology, Yunnan Agricultural University, Kunming, 650201, China.
authors.forename: Jiming
authors.initials: J
authors.lastname: Chen
authors.affiliation: Key Laboratory of Pu-er Tea Science, Ministry of Education, Yunnan Agricultural University, Kunming, 650201, China.|Tea Research Center of Yunnan, Kunming, 650201, China.|College of Food Science and Technology, Yunnan Agricultural University, Kunming, 650201, China.
authors.forename: Yewei
authors.initials: Y
authors.lastname: Huang
authors.affiliation: Key Laboratory of Pu-er Tea Science, Ministry of Education, Yunnan Agricultural University, Kunming, 650201, China.|Tea Research Center of Yunnan, Kunming, 650201, China.|College of Longrun Pu-er Tea, Yunnan Agricultural University, Kunming, 650201, China.
authors.forename: Xuanjun
authors.initials: X
authors.lastname: Wang
authors.affiliation: Key Laboratory of Pu-er Tea Science, Ministry of Education, Yunnan Agricultural University, Kunming, 650201, China.|Tea Research Center of Yunnan, Kunming, 650201, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Sheng
mesh_terms: D016604:Aflatoxin B1 / Q000378:metabolism* / Q000633:toxicity; D000818:Animals; D018938:Caco-2 Cells; D006801:Humans; D008099:Liver / Q000378:metabolism; D008297:Male; D010084:Oxidation-Reduction; D028321:Plant Preparations / Q000378:metabolism*; D059808:Polyphenols / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013662:Tea / Q000737:chemistry / Q000378:metabolism*
chemical_list: D028321:Plant Preparations; D059808:Polyphenols; D013662:Tea; D016604:Aflatoxin B1
keywords: AFB1; absorption; complexed aflatoxin B1; oxidised tea polyphenols