title: Direct Cardiac Cellular Reprogramming for Cardiac Regeneration.
abstract: Direct cardiac cellular reprogramming of endogenous cardiac fibroblasts directly into induced cardiomyocytes is a highly feasible, promising therapeutic option for patients with advanced heart failure. The most successful cardiac reprogramming strategy will likely be a multimodal approach involving an optimal combination of cardio-differentiating factors, suppression of fibroblast gene expression, and induction of angiogenic factors.
authors.affiliation: Michael E. DeBakey Department of Surgery, Baylor College of Medicine, 6501 Fannin Street, Suite NC114, Houston, TX, 77030, USA.
authors.forename: Vivekkumar
authors.initials: V
authors.lastname: Patel
authors.affiliation: Michael E. DeBakey Department of Surgery, Baylor College of Medicine, 6501 Fannin Street, Suite NC114, Houston, TX, 77030, USA.
authors.forename: Megumi
authors.initials: M
authors.lastname: Mathison
authors.affiliation: Michael E. DeBakey Department of Surgery, Baylor College of Medicine, 6501 Fannin Street, Suite NC114, Houston, TX, 77030, USA.
authors.forename: Vivek P
authors.initials: VP
authors.lastname: Singh
authors.affiliation: Michael E. DeBakey Department of Surgery, Baylor College of Medicine, 6501 Fannin Street, Suite NC114, Houston, TX, 77030, USA.
authors.forename: Jianchang
authors.initials: J
authors.lastname: Yang
authors.affiliation: Michael E. DeBakey Department of Surgery, Baylor College of Medicine, 6501 Fannin Street, Suite NC114, Houston, TX, 77030, USA. Todd.Rosengart@bcm.edu.
authors.forename: Todd K
authors.initials: TK
authors.lastname: Rosengart
keywords: Cardiomyocyte; GMT; Gene therapy; Heart failure; Reprogramming; Transdifferentiation