title: Proteomics for Allergy: from Proteins to the Patients.
abstract: Proteomics encompasses a variety of approaches unraveling both the structural features, post-translational modifications, and abundance of proteins. As of today, proteomic studies have shed light on the primary structure of about 850 allergens, enabling the design of microarrays for improved molecular diagnosis. Proteomic methods including mass spectrometry allow as well to investigate protein-protein interactions, thus yielding precise information on critical epitopes on the surface of allergens. Mass spectrometry is now being applied to the unambiguous identification, characterization, and comprehensive quantification of allergens in a variety of matrices, as diverse as food samples and allergen immunotherapy drug products. As such, it represents a method of choice for quality testing of allergen immunotherapy products.
authors.affiliation: Stallergenes Greer, Research Department, 6 rue Alexis de Tocqueville, 92183, Antony cedex, France. enony@stallergenes.com.
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Nony
authors.affiliation: Stallergenes Greer, Research Department, 6 rue Alexis de Tocqueville, 92183, Antony cedex, France.
authors.forename: Maxime
authors.initials: M
authors.lastname: Le Mignon
authors.affiliation: Stallergenes Greer, Research Department, 6 rue Alexis de Tocqueville, 92183, Antony cedex, France.
authors.forename: Sébastien
authors.initials: S
authors.lastname: Brier
authors.affiliation: Stallergenes Greer, Research Department, 6 rue Alexis de Tocqueville, 92183, Antony cedex, France.
authors.forename: Armelle
authors.initials: A
authors.lastname: Martelet
authors.affiliation: Stallergenes Greer, Research Department, 6 rue Alexis de Tocqueville, 92183, Antony cedex, France.
authors.forename: Philippe
authors.initials: P
authors.lastname: Moingeon
mesh_terms: D006801:Humans; D006967:Hypersensitivity / Q000175:diagnosis*; D007167:Immunotherapy / Q000379:methods*; D040901:Proteomics / Q000379:methods*
keywords: Allergen; Allergen extracts; Allergen immunotherapy; Mass spectrometry; Proteomics