title: Anti-myeloma activity of MELK inhibitor OTS167: effects on drug-resistant myeloma cells and putative myeloma stem cell replenishment of malignant plasma cells.
authors.affiliation: Department of Medicine, University of Chicago, Chicago, IL, USA.
authors.forename: A T
authors.initials: AT
authors.lastname: Stefka
authors.affiliation: Department of Medicine, University of Chicago, Chicago, IL, USA.
authors.forename: J-H
authors.initials: JH
authors.lastname: Park
authors.affiliation: OncoTherapy Science, Inc., Kawasaki, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Matsuo
authors.affiliation: OncoTherapy Science, Inc., Kawasaki, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Chung
authors.affiliation: Department of Medicine, University of Chicago, Chicago, IL, USA.|Department of Surgery, University of Chicago, Chicago, IL, USA.
authors.forename: Y
authors.initials: Y
authors.lastname: Nakamura
authors.affiliation: Department of Medicine, University of Chicago, Chicago, IL, USA.
authors.forename: A J
authors.initials: AJ
authors.lastname: Jakubowiak
authors.affiliation: Department of Medicine, University of Chicago, Chicago, IL, USA.
authors.forename: S
authors.initials: S
authors.lastname: Rosebeck
mesh_terms: D000970:Antineoplastic Agents / Q000494:pharmacology* / Q000627:therapeutic use; D001854:Bone Marrow Cells / Q000187:drug effects / Q000473:pathology; D002478:Cells, Cultured; D004305:Dose-Response Relationship, Drug; D019008:Drug Resistance, Neoplasm / Q000187:drug effects*; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D009101:Multiple Myeloma / Q000188:drug therapy / Q000473:pathology*; D009287:Naphthyridines / Q000494:pharmacology* / Q000627:therapeutic use; D014411:Neoplastic Stem Cells / Q000187:drug effects* / Q000473:pathology; D010950:Plasma Cells / Q000187:drug effects* / Q000473:pathology; D047428:Protein Kinase Inhibitors / Q000494:pharmacology* / Q000627:therapeutic use; D017346:Protein Serine-Threonine Kinases / Q000037:antagonists & inhibitors*; D059016:Tumor Microenvironment / Q000187:drug effects
chemical_list: D000970:Antineoplastic Agents; D009287:Naphthyridines; D047428:Protein Kinase Inhibitors; C484610:MELK protein, human; D017346:Protein Serine-Threonine Kinases; C000626727:OTS167