title: Gold nanostars for efficient in vitro and in vivo real-time SERS detection and drug delivery via plasmonic-tunable Raman/FTIR imaging.
abstract: The application of plasmonic-enhanced Raman imaging of cancer cells and drug delivery is gaining momentum. Here, we propose a new theranostic strategy based on an efficient plasmonic-tunable Raman/Fourier transform infrared (FTIR) spectroscopy imaging, to simultaneously evaluate the anticancer drug scattering cellular imaging and the Raman scattering molecular vibration signals in living cells. This technique allows to monitoring the drug release throughout the cell cycle and in vivo biodistribution and biocompatibility with low dose drug therapy (200 μg/mL) and low toxicity effect. This system can directly track in real-time the delivery and release of an anticancer drug (mitoxantrone, MTX) from gold nanostars in single living cells and in mice (healthy and lung cancer mice models), revealing a strong accumulation in the heart of healthy mice 5 min after administration and infiltration in the tumor site of lung cancer mice 5 h after systemic injection. This in vivo SERS detection method holds a great promise for application in image-guided cancer chemotherapy or as a nonspecific anti-inflammatory therapy for patients with cardiovascular diseases or chronic heart failure.
authors.affiliation: School of Food Science and Environmental Health, College of Sciences and Health, Dublin Institute of Technology, Dublin, Ireland. Electronic address: furong.tian@dit.ie.
authors.forename: Furong
authors.initials: F
authors.lastname: Tian
authors.affiliation: Massachusetts Institute of Technology, Institute for Medical Engineering and Science, Harvard-MIT Division for Health Sciences and Technology, Cambridge, MA, USA; School of Engineering and Materials Science, Queen Mary University of London, London, UK. Electronic address: jdconde@mit.edu.
authors.forename: João
authors.initials: J
authors.lastname: Conde
authors.affiliation: Department of Bio-Nano Science and Engineering, School of Electronic Information and Electrical Engineering, Shanghai Jiao Tong University, PR China; Dept. of Instrument Science and Engineering, School of Electronic Information and Electrical Engineering, Shanghai Jiao Tong University, PR China; United Well Technology Limited, Shanghai, PR China.
authors.forename: Chenchen
authors.initials: C
authors.lastname: Bao
authors.affiliation: Department of Bio-Nano Science and Engineering, School of Electronic Information and Electrical Engineering, Shanghai Jiao Tong University, PR China; Dept. of Instrument Science and Engineering, School of Electronic Information and Electrical Engineering, Shanghai Jiao Tong University, PR China.
authors.forename: Yunsheng
authors.initials: Y
authors.lastname: Chen
authors.affiliation: School of Food Science and Environmental Health, College of Sciences and Health, Dublin Institute of Technology, Dublin, Ireland.
authors.forename: James
authors.initials: J
authors.lastname: Curtin
authors.affiliation: Department of Bio-Nano Science and Engineering, School of Electronic Information and Electrical Engineering, Shanghai Jiao Tong University, PR China; Dept. of Instrument Science and Engineering, School of Electronic Information and Electrical Engineering, Shanghai Jiao Tong University, PR China.
authors.forename: Daxiang
authors.initials: D
authors.lastname: Cui
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000737:chemistry; D045744:Cell Line, Tumor; D003199:Computer Systems; D003287:Contrast Media / Q000737:chemistry; D016903:Drug Monitoring / Q000379:methods; D006046:Gold / Q000008:administration & dosage / Q000737:chemistry; D053768:Metal Nanoparticles / Q000008:administration & dosage* / Q000737:chemistry / Q000648:ultrastructure; D051379:Mice; D057054:Molecular Imaging / Q000379:methods; D053769:Nanocapsules / Q000008:administration & dosage* / Q000737:chemistry / Q000648:ultrastructure; D009369:Neoplasms / Q000188:drug therapy* / Q000473:pathology*; D017550:Spectroscopy, Fourier Transform Infrared / Q000379:methods*; D013059:Spectrum Analysis, Raman / Q000379:methods*; D020349:Surface Plasmon Resonance / Q000379:methods*; D000068936:Theranostic Nanomedicine / Q000379:methods; D016896:Treatment Outcome
chemical_list: D000970:Antineoplastic Agents; D003287:Contrast Media; D053769:Nanocapsules; D006046:Gold
keywords: Drug delivery; Gold nanostars; In vivo SERS; Raman/FTIR imaging; Theranostics