title: The electrophysiological response to immunoglobulin therapy in chronic inflammatory demyelinating polyneuropathy.
abstract: OBJECTIVE
  To characterize changes in motor nerve conduction studies (MNCS) and motor unit number index (MUNIX) following treatment with subcutaneous immunoglobulin and to assess whether these changes are related to muscle strength.
  
  
  METHODS
  Data from 23 patients participating in a randomized, controlled trial were analyzed. MNCS and MUNIX were performed before and after 12 weeks of treatment. Isokinetic strength (IMS) was measured in various muscles together with grip strength (GS).
  
  
  RESULTS
  Proximally evoked compound muscle action potential (CMAP) amplitudes and MUNIX tended to be better preserved in treated patients (P=.049 and .045). Changes in other parameters did not differ between groups. There was no correlation between changes in electrophysiological parameters and IMS. Changes in GS were related to median nerve motor conduction velocity, distal motor latency, CMAP amplitudes, and distally evoked CMAP duration (P=.013-.035).
  
  
  CONCLUSIONS
  Proximally evoked CMAP amplitudes appear to be the best MNCS parameter to assess treatment outcome in chronic inflammatory demyelinating polyneuropathy.
authors.affiliation: Department of Clinical Neurophysiology, Aarhus University Hospital, Aarhus, Denmark.
authors.forename: M
authors.initials: M
authors.lastname: Otto
authors.affiliation: Department of Neurology, Aarhus University Hospital, Aarhus, Denmark.
authors.forename: L
authors.initials: L
authors.lastname: Markvardsen
authors.affiliation: Department of Clinical Neurophysiology, Aarhus University Hospital, Aarhus, Denmark.
authors.forename: H
authors.initials: H
authors.lastname: Tankisi
authors.affiliation: Department of Neurology, Aarhus University Hospital, Aarhus, Denmark.|Neuroscience Center, Rigshospitalet, Copenhagen, Denmark.
authors.forename: J
authors.initials: J
authors.lastname: Jakobsen
authors.affiliation: Department of Clinical Neurophysiology, Aarhus University Hospital, Aarhus, Denmark.
authors.forename: A
authors.initials: A
authors.lastname: Fuglsang-Frederiksen
mesh_terms: D000328:Adult; D000368:Aged; D019054:Evoked Potentials, Motor; D005260:Female; D006801:Humans; D007116:Immunization, Passive; D007136:Immunoglobulins / Q000008:administration & dosage / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D053580:Muscle Strength; D009431:Neural Conduction; D020277:Polyradiculoneuropathy, Chronic Inflammatory Demyelinating / Q000628:therapy*
chemical_list: D007136:Immunoglobulins
keywords: chronic inflammatory demyelinating polyneuropathy; motor nerve conduction studies; motor unit number index; subcutaneous immunoglobulin therapy