title: The Use of Rat and Mouse Models in Bariatric Surgery Experiments.
abstract: Animal models have been proven to be a crucial tool for investigating the physiological mechanisms underlying bariatric surgery in general and individual techniques in particular. By using a translational approach, most of these studies have been performed in rodents and have helped to understand how bariatric surgery may or may not work. However, data from studies using animal models should always be critically evaluated for their transferability to the human physiology. It is, therefore, the aim of this review to summarize both advantages and limitations of data generated by animal based experiments designed to investigate and understand the physiological mechanisms at the root of bariatric surgery.
authors.affiliation: Vetsuisse Faculty, Institute of Veterinary Physiology, University of Zurich, Zurich, Switzerland; Centre for Integrative Human Physiology, University of Zurich, Zurich, Switzerland.
authors.forename: Thomas A
authors.initials: TA
authors.lastname: Lutz
authors.affiliation: Centre for Integrative Human Physiology, University of Zurich, Zurich, Switzerland; Department of Surgery, Division of Visceral and Transplant Surgery, University Hospital Zurich, Zurich, Switzerland.
authors.forename: Marco
authors.initials: M
authors.lastname: Bueter
keywords: RYGB; VSG; energy expenditure; food intake; human; mouse; rat