title: Mammary analogue secretory carcinoma of the salivary glands: a diagnostic dilemma.
abstract: Mammary analogue secretory carcinoma (MASC) is a recently identified salivary gland neoplasm that can mimic other salivary gland tumours such as acinic cell carcinoma and cystadenocarcinoma. It is distinguished from these by differences in immunohistochemical profile and the identification of an ETV6-NTRK3 translocation (12;15)(p13;q25), which is also found in secretory carcinomas of the breast. Previous publications have suggested that MASC tumours have similar biological behaviour to acinic cell carcinoma. We report two cases of MASC that affected the upper lip, and showed an infiltrative and locally aggressive growth pattern that required several operations to ensure clearance of microscopic tumour cells.
authors.affiliation: Department of Oral & Maxillofacial Surgery, University Hospitals Bristol, Upper Maudlin Street, Bristol, BS2 8HW, United Kingdom. Electronic address: Nishma@Hindocha.se.
authors.forename: N
authors.initials: N
authors.lastname: Hindocha
authors.affiliation: Department of Oral & Maxillofacial Surgery, University Hospitals Bristol, Upper Maudlin Street, Bristol, BS2 8HW, United Kingdom.
authors.forename: M H
authors.initials: MH
authors.lastname: Wilson
authors.affiliation: Department of Oral & Maxillofacial Surgery, University Hospitals Bristol, Upper Maudlin Street, Bristol, BS2 8HW, United Kingdom.
authors.forename: M
authors.initials: M
authors.lastname: Pring
authors.affiliation: Department of Oral & Maxillofacial Surgery, University Hospitals Bristol, Upper Maudlin Street, Bristol, BS2 8HW, United Kingdom.
authors.forename: C W
authors.initials: CW
authors.lastname: Hughes
authors.affiliation: Department of Oral & Maxillofacial Surgery, University Hospitals Bristol, Upper Maudlin Street, Bristol, BS2 8HW, United Kingdom.
authors.forename: S J
authors.initials: SJ
authors.lastname: Thomas
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D008297:Male; D000069295:Mammary Analogue Secretory Carcinoma / Q000175:diagnosis*; D008875:Middle Aged; D012468:Salivary Gland Neoplasms / Q000175:diagnosis*
keywords: ETV6-NTRK3 translocation; MASC; Mammary analogue secretory carcinoma; lip; minor salivary gland; salivary gland malignancy