title: Selective Laser Trabeculoplasty Reduces Intraocular Pressure Peak in Response to the Water Drinking Test.
abstract: To determine the effect of selective laser trabeculoplasty (SLT) on intraocular pressure (IOP) peak and fluctuation induced by the water drinking test (WDT) in patients with open-angle glaucoma and ocular hypertension.
  
  
  
  Patients with open-angle glaucoma or ocular hypertension underwent the WDT before and after SLT within a 12-month period. No other changes to therapeutic regimen were permitted. IOP was measured with a Goldmann applanation tonometer at baseline and every 15 minutes for 45 minutes following a fluid challenge of 800 mL over 15 minutes. Baseline, peak, and percentage fluctuation in IOP from baseline were compared using a repeated measures analysis of variance with Bonferroni adjustment.
  
  
  
  Twenty eyes from 20 patients were included in this study. The median patient age was 73±15 years (interquartile range) and 70% of patients were female. Ten eyes (50%) had a diagnosis of primary open-angle glaucoma and 10 eyes had ocular hypertension. Following SLT there was a statistically significant reduction in mean baseline IOP from 16.9±2.4 to 14.2±2.3 mm Hg (P<0.001), peak IOP from 21.9±3.7 to 16.9±3.1 mm Hg (P<0.001).
  
  
  
  Patients with open-angle glaucoma and ocular hypertension treated with SLT have significantly reduced peak IOPs and fluctuation in IOP in response to the WDT.
authors.affiliation: *Royal Victorian Eye and Ear Hospital †Glaucoma Care, Melbourne §University of Melbourne Department of Surgery, Royal Melbourne Hospital, Parkvilee, Vic. ‡Discipline of Ophthalmology, University of Sydney, Sydney, NSW, Australia.
authors.forename: Nathan M
authors.initials: NM
authors.lastname: Kerr
authors.forename: Henry R
authors.initials: HR
authors.lastname: Lew
authors.forename: Simon E
authors.initials: SE
authors.lastname: Skalicky
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D003941:Diagnostic Techniques, Ophthalmological; D004326:Drinking; D005260:Female; D005902:Glaucoma, Open-Angle / Q000175:diagnosis / Q000503:physiopathology / Q000601:surgery*; D006801:Humans; D007429:Intraocular Pressure / Q000502:physiology*; D053685:Laser Therapy; D053844:Lasers, Solid-State; D008297:Male; D008875:Middle Aged; D009798:Ocular Hypertension / Q000175:diagnosis / Q000503:physiopathology / Q000601:surgery; D014065:Tonometry, Ocular; D014130:Trabeculectomy / Q000379:methods*; D014867:Water / Q000008:administration & dosage*
chemical_list: D014867:Water