title: Fetal development of the corpus callosum: Insights from a 3T DTI and tractography study in a patient with segmental callosal agenesis.
abstract: Commissural embryology mechanisms are not yet completely understood. The study and comprehension of callosal dysgenesis can provide remarkable insights into embryonic or fetal commissural development. The diffusion tensor imaging (DTI) technique allows the in vivo analyses of the white-matter microstructure and is a valid tool to clarify the disturbances of brain connections in patients with dysgenesis of the corpus callosum (CC). The segmental callosal agenesis (SCAG) is a rare partial agenesis of the corpus callosum (ACC). In a newborn with SCAG the DTI and tractography analyses proved that the CC was made of two separate segments consisting respectively of the ventral part in the genu and body of the CC, connecting the frontal lobes, and the dorsal part in the CC splenium and the attached hippocampal commissure (HC), connecting the parietal lobes and the fornix. These findings support the embryological thesis of a separated origin of the ventral and the dorsal parts of the CC.
authors.affiliation: Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Department of Neuroradiology, Italy elisascola80@gmail.com.
authors.forename: Elisa
authors.initials: E
authors.lastname: Scola
authors.affiliation: Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Università degli Studi di Milano, NICU, Department of Clinical Sciences and Community Health, Italy.
authors.forename: Ida
authors.initials: I
authors.lastname: Sirgiovanni
authors.affiliation: Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Department of Neuroradiology, Italy.
authors.forename: Sabrina
authors.initials: S
authors.lastname: Avignone
authors.affiliation: Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Department of Neuroradiology, Italy.
authors.forename: Claudia Maria
authors.initials: CM
authors.lastname: Cinnante
authors.affiliation: Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Department of Neuroradiology, Italy.
authors.forename: Riccardo
authors.initials: R
authors.lastname: Biffi
authors.affiliation: Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Università degli Studi di Milano, NICU, Department of Clinical Sciences and Community Health, Italy Università degli Studi di Milano, Italy.
authors.forename: Monica
authors.initials: M
authors.lastname: Fumagalli
authors.affiliation: Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Department of Neuroradiology, Italy Università degli Studi di Milano, Italy.
authors.forename: Fabio
authors.initials: F
authors.lastname: Triulzi
mesh_terms: D061085:Agenesis of Corpus Callosum / Q000000981:diagnostic imaging*; D003337:Corpus Callosum / Q000000981:diagnostic imaging* / Q000196:embryology; D056324:Diffusion Tensor Imaging; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008297:Male; D011247:Pregnancy
keywords: DTI; MRI; corpus callosum; development; segmental callosal agenesis