title: Carotid plaque and bone density and microarchitecture in psoriatic arthritis: the correlation with soluble ST2.
abstract: Psoriatic arthritis (PsA) patients have increased risk of both atherosclerosis and osteoporosis. Previous studies revealed that IL-33/ST2 axis may be related to both conditions; however, these associations were never evaluated in a single patients' group. Here we explored the association among plasma levels of IL-33 and its decoy receptor soluble ST2 (sST2), carotid plaque determined by ultrasound, and volumetric bone mineral density (vBMD)/microstructure of distal radius measured by high-resolution peripheral quantitative computed tomography (HR-pQCT) in 80 PsA patients (55% male; 53.0 ± 10.1 years). Plasma sST2 levels were significantly higher in 33 (41%) patients with carotid plaques (11.2 ± 4.5 vs 7.7 ± 3.7 ng/ml, P < 0.001). In multivariate analysis, sST2 was an independent explanatory variable associated with carotid plaques (OR = 1.296, 95% CI: [1.091,1.540]; P = 0.003). After adjustment for the osteoporotic risk factors, sST2 was significantly associated with higher cortical porosity (β = 0.184, [0.042,0.325]; P = 0.012) and cortical pore volume (2.247, [0.434,4.060]; P = 0.016); and had a trend to be associated with lower cortical vBMD (-2.918, [-6.111,0.275]; P = 0.073). IL-33 was not associated with carotid plaque or vBMD/microstructure. In conclusion, plasma sST2 levels were independently correlated with both carotid plaque and compromised cortical vBMD/microstructure in PsA patients. IL-33/ST2 axis may be a link between accelerated atherosclerosis and osteoporosis in PsA.
authors.affiliation: Department of Medicine &Therapeutics, The Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong.
authors.forename: Jiayun
authors.initials: J
authors.lastname: Shen
authors.affiliation: Department of Medicine &Therapeutics, The Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong.
authors.forename: Qing
authors.initials: Q
authors.lastname: Shang
authors.affiliation: Department of Chemical Pathology, The Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong.
authors.forename: Chun-Kwok
authors.initials: CK
authors.lastname: Wong
authors.affiliation: Department of Medicine &Therapeutics, The Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong.
authors.forename: Edmund K
authors.initials: EK
authors.lastname: Li
authors.affiliation: Department of Medicine and Geriatrics, Taipo Hospital, Hong Kong.
authors.forename: Emily W
authors.initials: EW
authors.lastname: Kun
authors.affiliation: Department of Medicine &Therapeutics, The Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong.
authors.forename: Isaac T
authors.initials: IT
authors.lastname: Cheng
authors.affiliation: Department of Medicine &Therapeutics, The Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong.
authors.forename: Martin
authors.initials: M
authors.lastname: Li
authors.affiliation: Department of Medicine &Therapeutics, The Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong.
authors.forename: Tena K
authors.initials: TK
authors.lastname: Li
authors.affiliation: Bone Quality and Health Center of the Department of Orthopedics &Traumatology, The Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong.
authors.forename: Tracy Y
authors.initials: TY
authors.lastname: Zhu
authors.affiliation: Department of Medicine &Therapeutics, The Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong.
authors.forename: Cheuk-Man
authors.initials: CM
authors.lastname: Yu
authors.affiliation: Bone Quality and Health Center of the Department of Orthopedics &Traumatology, The Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong.
authors.forename: Ling
authors.initials: L
authors.lastname: Qin
authors.affiliation: Department of Medicine &Therapeutics, The Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong.
authors.forename: Lai-Shan
authors.initials: LS
authors.lastname: Tam
mesh_terms: D000328:Adult; D015535:Arthritis, Psoriatic / Q000097:blood* / Q000503:physiopathology*; D015519:Bone Density; D059168:Carotid Intima-Media Thickness; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D000072179:Interleukin-1 Receptor-Like 1 Protein / Q000097:blood*; D000067596:Interleukin-33 / Q000097:blood; D008297:Male; D008875:Middle Aged; D058226:Plaque, Atherosclerotic / Q000000981:diagnostic imaging / Q000209:etiology
chemical_list: C079241:IL1RL1 protein, human; C506536:IL33 protein, human; D000072179:Interleukin-1 Receptor-Like 1 Protein; D000067596:Interleukin-33