title: IL-33 Signaling in Lung Injury.
abstract: Interleukin (IL)-33, a member of the IL-1 cytokine super-family, acts as both a traditional cytokine and an intracellular nuclear factor. It is generally released from damaged immune cells and signals through its receptor ST2 in an autocrine and paracrine fashion, plays important roles in type-2 innate immunity, and functions as an "alarmin" or a danger signal for cellular damage or cellular stress. Here, we review recent advances of the role of IL-33 in lung injury and explore its potential significance as an attractive therapeutic target.
authors.affiliation: Department of Anesthesiology, Shanghai Children's Medical Center, Shanghai Jiao-Tong University School of Medicine (SJTU-SM), Shanghai, P.R. China.|Department of Anesthesiology, University of Pittsburgh School of Medicine and University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, U.S.A.
authors.forename: Jing
authors.initials: J
authors.lastname: Chang
authors.affiliation: Department of Anesthesiology, Hunan Cancer Hospital, Xiangya School of Medicine, Central South University, Changsha, Hunan Province, P.R. China.|Department of Anesthesiology, University of Pittsburgh School of Medicine and University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, U.S.A.
authors.forename: Yue-Feng
authors.initials: YF
authors.lastname: Xia
authors.affiliation: Department of Anesthesiology, Shanghai Children's Medical Center, Shanghai Jiao-Tong University School of Medicine (SJTU-SM), Shanghai, P.R. China.
authors.forename: Ma-Zhong
authors.initials: MZ
authors.lastname: Zhang
authors.affiliation: Department of Anesthesiology, University of Pittsburgh School of Medicine and University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, U.S.A.
authors.forename: Li-Ming
authors.initials: LM
authors.lastname: Zhang
keywords: interleukin-33 (IL-33); lung injury; ventilator-induced lung injury (VILI)