title: Multidrug-Resistant Shigella Infections in Patients with Diarrhea, Cambodia, 2014-2015.
abstract: We observed multidrug resistance in 10 (91%) of 11 Shigella isolates from a diarrheal surveillance study in Cambodia. One isolate was resistant to fluoroquinolones and cephalosporins and showed decreased susceptibility to azithromycin. We found mutations in gyrA, parC, β-lactamase, and mphA genes. Multidrug resistance increases concern about shigellosis treatment options.
authors.forename: Kamonporn
authors.initials: K
authors.lastname: Poramathikul
authors.forename: Ladaporn
authors.initials: L
authors.lastname: Bodhidatta
authors.forename: Sivhour
authors.initials: S
authors.lastname: Chiek
authors.forename: Wilawan
authors.initials: W
authors.lastname: Oransathid
authors.forename: Sirigade
authors.initials: S
authors.lastname: Ruekit
authors.forename: Panida
authors.initials: P
authors.lastname: Nobthai
authors.forename: Woradee
authors.initials: W
authors.lastname: Lurchachaiwong
authors.forename: Oralak
authors.initials: O
authors.lastname: Serichantalergs
authors.forename: Chanthap
authors.initials: C
authors.lastname: Lon
authors.forename: Brett
authors.initials: B
authors.lastname: Swierczewski
mesh_terms: D000293:Adolescent; D000328:Adult; D000900:Anti-Bacterial Agents / Q000494:pharmacology* / Q000627:therapeutic use; D002160:Cambodia / Q000453:epidemiology; D002675:Child, Preschool; D003967:Diarrhea / Q000188:drug therapy / Q000453:epidemiology* / Q000266:history / Q000382:microbiology*; D024901:Drug Resistance, Multiple, Bacterial; D004405:Dysentery, Bacillary / Q000188:drug therapy / Q000453:epidemiology* / Q000266:history / Q000382:microbiology*; D005260:Female; D005798:Genes, Bacterial; D049674:History, 21st Century; D006801:Humans; D007223:Infant; D008297:Male; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D009154:Mutation; D011159:Population Surveillance; D012760:Shigella / Q000187:drug effects* / Q000235:genetics; D055815:Young Adult
chemical_list: D000900:Anti-Bacterial Agents
keywords: Cambodia; MDR genes; Shigella; antimicrobial resistance; bacteria; bacterial infections; dysentery; enteric infections