title: TNFSF4 Gene Variations Are Related to Early-Onset Autoimmune Thyroid Diseases and Hypothyroidism of Hashimoto's Thyroiditis.
abstract: The aim of the current study was to examine whether the polymorphism loci of the tumor necrosis factor superfamily member 4 (TNFSF4) gene increase the risk of susceptibility to autoimmune thyroid diseases (AITDs) in the Han Chinese population, and a case-control study was performed in a set of 1,048 AITDs patients and 909 normal healthy controls in the study. A total of four tagging single nucleotide polymorphisms (SNPs) in the TNFSF4 region, including rs7514229, rs1234313, rs16845607 and rs3850641, were genotyped using the method of ligase detection reaction. An association between GG genotype of rs3850641 in TNFSF4 gene and AITDs was found (p = 0.046). Additionally, the clinical sub-phenotype analysis revealed a significant association between GG genotype in rs7514229 and AITDs patients who were ≤18 years of age. Furthermore, rs3850641 variant allele G was in strong association with hypothyroidism in Hashimoto's thyroiditis (HT) (p = 0.018). The polymorphisms of the TNFSF4 gene may contribute to the susceptibility to AITDs pathogenesis.
authors.affiliation: Department of Endocrinology, Jinshan Hospital of Fudan University, No. 1508 Longhang Road, Jinshan District, Shanghai 201508, China. someonesrh66@163.com.
authors.forename: Rong-Hua
authors.initials: RH
authors.lastname: Song
authors.affiliation: The hemodialysis center of Nephropathy Department, Shaanxi Provincial People's Hospital, No. 256 West Youyi Road, Beilin District, Xi'an 710068, China. wq9930@126.com.
authors.forename: Qiong
authors.initials: Q
authors.lastname: Wang
authors.affiliation: Department of Endocrinology, Jinshan Hospital of Fudan University, No. 1508 Longhang Road, Jinshan District, Shanghai 201508, China. 14211270001@fudan.edu.cn.
authors.forename: Qiu-Ming
authors.initials: QM
authors.lastname: Yao
authors.affiliation: Department of Endocrinology, Jinshan Hospital of Fudan University, No. 1508 Longhang Road, Jinshan District, Shanghai 201508, China. shaoxq2015@163.com.
authors.forename: Xiao-Qing
authors.initials: XQ
authors.lastname: Shao
authors.affiliation: Department of Endocrinology, Jinshan Hospital of Fudan University, No. 1508 Longhang Road, Jinshan District, Shanghai 201508, China. alana3344@126.com.
authors.forename: Ling
authors.initials: L
authors.lastname: Li
authors.affiliation: Department of Endocrinology, Jinshan Hospital of Fudan University, No. 1508 Longhang Road, Jinshan District, Shanghai 201508, China. wwen910108@163.com.
authors.forename: Wen
authors.initials: W
authors.lastname: Wang
authors.affiliation: Department of Endocrinology, Jinshan Hospital of Fudan University, No. 1508 Longhang Road, Jinshan District, Shanghai 201508, China. anxiaofei2000@163.com.
authors.forename: Xiao-Fei
authors.initials: XF
authors.lastname: An
authors.affiliation: Department of Endocrinology, Jinshan Hospital of Fudan University, No. 1508 Longhang Road, Jinshan District, Shanghai 201508, China. ellen38668@163.com.
authors.forename: Qian
authors.initials: Q
authors.lastname: Li
authors.affiliation: Department of Endocrinology, Jinshan Hospital of Fudan University, No. 1508 Longhang Road, Jinshan District, Shanghai 201508, China. zhangjinan@hotmail.com.
authors.forename: Jin-An
authors.initials: JA
authors.lastname: Zhang
mesh_terms: D000293:Adolescent; D000328:Adult; D000483:Alleles; D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000235:genetics; D005838:Genotype; D006239:Haplotypes / Q000235:genetics; D050031:Hashimoto Disease / Q000235:genetics* / Q000473:pathology*; D006801:Humans; D007037:Hypothyroidism / Q000235:genetics* / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D053278:OX40 Ligand / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D013967:Thyroiditis, Autoimmune / Q000235:genetics* / Q000473:pathology*; D055815:Young Adult
chemical_list: D053278:OX40 Ligand; C089251:TNFSF4 protein, human
keywords: Graves’ disease (GD); Hashimoto’s thyroiditis (HT); autoimmune thyroid diseases (AITDs); single nucleotide polymorphism (SNP); tumor necrosis factor superfamily member 4 (TNFSF4)