title: Effects of Native Type II Collagen Treatment on Knee Osteoarthritis: A Randomized Controlled Trial.
abstract: OBJECTIVE
  The aim of this randomized controlled study was to evaluate the efficacy of oral native type II collagen treatment on the symptoms and biological markers of cartilage degradation, when given concomitantly with acetaminophen in patients with knee osteoarthritis.
  
  
  METHODS
  Thirty-nine patients diagnosed with knee osteoarthritis were included and randomly distributed into two groups: one treated with 1500 mg/day of acetaminophen (group AC; n=19) and the other treated with 1500 mg/day of acetaminophen plus 10 mg/day of native type II collagen (group AC+CII; n=20) for 3 months. Visual Analogue Scale (VAS) at rest and during walking, Western Ontario McMaster (WOMAC) pain, WOMAC function, and Short Form-36 (SF-36) scores, were recorded. Coll2-1, Coll2-1NO2 and Fibulin-3 levels were quantified in urine as biomarkers of disease progression. ClinicalTrials.gov: NCT02237989.
  
  
  RESULTS
  After 3 months of treatment, significant improvements compared to baseline were reported in joint pain (VAS walking), function (WOMAC) and quality of life (SF-36) in the AC+CII group, while only improvements in some subscales of the SF-36 survey and VAS walking were detected in the AC group. Comparisons between the groups revealed a significant difference in VAS walking score in favour of the AC+CII group as compared to AC group. Biochemical markers of cartilage degradation in urine did not significantly improve in any of the groups.
  
  
  CONCLUSIONS
  All in all, these results suggest that native type II collagen treatment combined with acetaminophen is superior to only acetaminophen for symptomatic treatment of patients with knee osteoarthritis.
authors.affiliation: Department of Physical Medicine and Rehabilitation of Yerkoy/Yozgat Public Hospital, Yozgat, Turkey.
authors.forename: Fulya
authors.initials: F
authors.lastname: Bakilan
authors.affiliation: Department of Physical Medicine and Rehabilitation, Eskişehir Osmangazi University School of Medicine, Eskişehir, Turkey.
authors.forename: Onur
authors.initials: O
authors.lastname: Armagan
authors.affiliation: Department of Physical Medicine and Rehabilitation, Eskişehir Osmangazi University School of Medicine, Eskişehir, Turkey.
authors.forename: Merih
authors.initials: M
authors.lastname: Ozgen
authors.affiliation: Department of Physical Medicine and Rehabilitation, Eskişehir Osmangazi University School of Medicine, Eskişehir, Turkey.
authors.forename: Funda
authors.initials: F
authors.lastname: Tascioglu
authors.affiliation: Department of Biostatistics, Eskişehir Osmangazi University School of Medicine, Eskişehir, Turkey.
authors.forename: Ozge
authors.initials: O
authors.lastname: Bolluk
authors.affiliation: Department of Biochemistry, Eskişehir Osmangazi University School of Medicine, Eskişehir, Turkey.
authors.forename: Ozkan
authors.initials: O
authors.lastname: Alatas
keywords: Acetaminophen; knee osteoarthritis; native type II collagen