title: Characteristics of bone turnover markers in rapidly destructive coxopathy.
abstract: The purpose of this study was to clarify bone turnover marker levels in rapidly destructive coxopathy (RDC). Twenty patients with RDC (mean age, 72 ± 11 years; 3 men, 17 postmenopausal women), 111 with osteoarthritis (OA) (age, 60 ± 10 years; 15 men, 13 premenopausal women, 83 postmenopausal women), and 18 with osteonecrosis of femoral head (ON) (55 ± 14 years; 11 men, 3 premenopausal women, 4 postmenopausal women), and 100 patients with femoral neck fracture (FNF) (81 ± 10 years; 27 men, 73 postmenopausal women) were included. Serum tartrate-resistant acid phosphatase 5b (TRACP-5b), bone alkaline phosphatase (BAP), matrix metalloproteinase-3 (MMP-3) levels, and bone mineral density (BMD) of proximal femur and lumbar spine were investigated. TRACP-5b levels were significantly higher in RDC than in OA and ON, whereas BAP levels were higher in RDC than in OA (P < 0.05). MMP-3 levels were higher in RDC and ON than in OA (P < 0.05). TRACP-5b were higher in RDC than OA (P < 0.05) and FNF (P < 0.05) in performing propensity score matching; there were no differences in BMD between RDC and OA. TRACP-5b showed the largest area under the curve (AUC, 0.82) according to receiver operating characteristic (ROC) curve analysis for diagnosing RDC against OA and ON. AUCs of BAP and MMP-3 were 0.78 and 0.74. The respective sensitivities and specificities were 70.0 % and 85.3 % for TRACP-5b (cutoff, 623 mU/dl), 95.0 % and 57.1 % for BAP (13.8 U/l), and 70.0 % and 76.4 % for MMP-3 (52.7 ng/ml). The lack of differences in BMD suggested that high bone turnover marker levels may reflect osteoclast cell activation in RDC hips. Serum TRACP-5b and BAP could be RDC markers.
authors.affiliation: Department of Orthopaedic Medical Engineering, Osaka University Graduate School of Medicine, Suita, Japan.
authors.forename: Hirohito
authors.initials: H
authors.lastname: Abe
authors.affiliation: Department of Orthopaedic Surgery, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka, 5650871, Japan. tsakai-osk@umin.ac.jp.
authors.forename: Takashi
authors.initials: T
authors.lastname: Sakai
authors.affiliation: Department of Orthopaedic Medical Engineering, Osaka University Graduate School of Medicine, Suita, Japan.
authors.forename: Takeshi
authors.initials: T
authors.lastname: Ogawa
authors.affiliation: Department of Orthopaedic Medical Engineering, Osaka University Graduate School of Medicine, Suita, Japan.
authors.forename: Masaki
authors.initials: M
authors.lastname: Takao
authors.affiliation: Department of Orthopaedic Medical Engineering, Osaka University Graduate School of Medicine, Suita, Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Nishii
authors.affiliation: Center of Arthroplasty, Kyowakai Hospital, Suita, Japan.
authors.forename: Nobuo
authors.initials: N
authors.lastname: Nakamura
authors.affiliation: Department of Orthopaedic Medical Engineering, Osaka University Graduate School of Medicine, Suita, Japan.
authors.forename: Nobuhiko
authors.initials: N
authors.lastname: Sugano
mesh_terms: D000328:Adult; D000368:Aged; D000469:Alkaline Phosphatase / Q000097:blood; D015415:Biomarkers / Q000097:blood*; D015519:Bone Density; D001847:Bone Diseases / Q000097:blood* / Q000201:enzymology; D016723:Bone Remodeling; D015331:Cohort Studies; D005260:Female; D005265:Femoral Neck Fractures / Q000097:blood / Q000201:enzymology; D006801:Humans; D008297:Male; D019278:Matrix Metalloproteinase 3 / Q000097:blood; D008875:Middle Aged; D010003:Osteoarthritis / Q000097:blood / Q000201:enzymology; D057216:Propensity Score; D012372:ROC Curve; D000071681:Tartrate-Resistant Acid Phosphatase / Q000097:blood
chemical_list: D015415:Biomarkers; D000469:Alkaline Phosphatase; D000071681:Tartrate-Resistant Acid Phosphatase; C511768:MMP3 protein, human; D019278:Matrix Metalloproteinase 3
keywords: Bone turnover marker; Hip disease; Osteoarthritis; Rapidly destructive coxopathy; Tartrate-resistant acid phosphatase 5