title: Refractory Arterial Insufficiency Associated with Janus Kinase 2 Positive Essential Thrombocythaemia.
abstract: Essential thrombocythaemia (ET) is one of the severe rare clonal haematologic stem cell disorders that encompass myeloproliferative neoplasms. ET has a well-described association with peripheral arterial thrombosis, which presents a challenging clinical presentation. Further understanding into the underlying pathophysiology of thrombosis in ET has been made following the identification of the Janus Kinase 2 (JAK2) mutation, which is thought to confer a prothrombotic phenotype. Here we present a case of refractory arterial insufficiency associated with JAK2-positive ET.
authors.affiliation: Department of Surgery, Bankstown-Lidcombe Hospital, Sydney, NSW, Australia. Electronic address: yogeesan.sivakumaran@gmail.com.
authors.forename: Yogeesan
authors.initials: Y
authors.lastname: Sivakumaran
authors.affiliation: Department of Surgery, Bankstown-Lidcombe Hospital, Sydney, NSW, Australia; Division of Surgery, Concord Hospital Clinical School, University of Sydney, Sydney, NSW, Australia.
authors.forename: Anthony
authors.initials: A
authors.lastname: Freeman
mesh_terms: D000671:Amputation, Surgical; D000800:Angioplasty, Balloon; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D001157:Arterial Occlusive Diseases / Q000175:diagnosis / Q000201:enzymology / Q000235:genetics* / Q000628:therapy; D000072226:Computed Tomography Angiography; D004252:DNA Mutational Analysis; D003646:Debridement; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D006918:Hydroxyurea / Q000627:therapeutic use; D053614:Janus Kinase 2 / Q000235:genetics*; D008875:Middle Aged; D009154:Mutation; D010641:Phenotype; D010975:Platelet Aggregation Inhibitors / Q000627:therapeutic use; D010976:Platelet Count; D013920:Thrombocythemia, Essential / Q000175:diagnosis / Q000188:drug therapy / Q000201:enzymology / Q000235:genetics*; D016896:Treatment Outcome; D014945:Wound Healing
chemical_list: D000900:Anti-Bacterial Agents; D010975:Platelet Aggregation Inhibitors; C507924:JAK2 protein, human; D053614:Janus Kinase 2; D006918:Hydroxyurea