title: Data on the expression of cellular lncRNAs in human adenovirus infected cells.
abstract: Expression of cellular long non-coding RNAs (lncRNAs) in human primary lung fibroblasts (IMR-90) during the course of adenovirus type 2 (Ad2) infection was studied by strand-specific whole transcriptome sequencing. In total, 645 cellular lncRNAs were expressed at a significant level and 398 of them were changed more than 2-fold. The changes in expression followed a distinct temporal pattern. Significantly, 80% of the changes occurred at the late phase and 80% of the de-regulated lncRNAs were up-regulated. The three largest groups of deregulated lncRNAs were 125 antisense RNAs, 111 pseudogenes and 85 long intergenic non-coding RNAs (lincRNAs). Lastly, more than 36% of lncRNAs have been shown to interact with RNA binding proteins.
authors.affiliation: Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, Victoria 3086, Australia.
authors.forename: Maoshan
authors.initials: M
authors.lastname: Chen
authors.affiliation: The Beijer Laboratory, Department of Immunology, Genetics and Pathology, Uppsala University, S-751 85 Uppsala, Sweden.
authors.forename: Hongxing
authors.initials: H
authors.lastname: Zhao
authors.affiliation: Department of Chemistry-BMC, Analytical Chemistry, Science for Life Laboratory, Uppsala University, Box 599, SE-751 24 Uppsala, Sweden.
authors.forename: Sara Bergström
authors.initials: SB
authors.lastname: Lind
authors.affiliation: The Beijer Laboratory, Department of Immunology, Genetics and Pathology, Uppsala University, S-751 85 Uppsala, Sweden.
authors.forename: Ulf
authors.initials: U
authors.lastname: Pettersson
keywords: Adenovirus; IMR-90; IncRNA; Long noncoding RNA