title: Glutathione S-transferase pi polymorphism contributes to the treatment outcomes of advanced non-small cell lung cancer patients in a Chinese population.
abstract: We analyzed the association between polymorphisms in three glutathione S-transferase genes (GSTP1, GSTM1, and GSTT1) and the treatment outcome for advanced non-small cell lung cancer (NSCLC). We recruited 284 NSCLC patients at advanced stage from Department of Radiotherapy in Peace Hospital Attached to Changzhi Medical College between May 2009 and May 2011, who had received cisplatin-based chemotherapy. The GSTP1, GSTM1, and GSTT1 genotyping for was determined using DNA pyrosequencing on an ABI Prism 3100 DNA analyzer. In the Cox proportional hazards model, the IIe/Val and Val/Val genotypes of GSTP1 were associated with lower risk of disease progression compared with the IIe/IIe genotype, and the HRs (95%CIs) were 0.37 (0.18-0.74) and 0.15 (0.06-0.35), respectively. The IIe/Val and Val/Val genotypes significantly decreased risk of death from all causes in patients with NSCLC, and the HRs (95%CIs) were 0.52 (0.29-0.92) and 0.37 (0.17- 0.79), respectively No significant association was observed between GSTM1 and GSTT1 polymorphisms and progression-free survival and overall survival in the NSCLC patients. In summary, we suggest that GSTP1 polymorphisms might influence the treatment outcome of advanced NSCLC patients, and our results could help improve individualized therapy.
authors.affiliation: Department of Radiotherapy, Peace Hospital Attached to Changzhi Medical College, Changzhi, Shanxi, China jianbc21@126.com.
authors.forename: J B
authors.initials: JB
authors.lastname: Chen
authors.affiliation: Department of Radiotherapy, Peace Hospital Attached to Changzhi Medical College, Changzhi, Shanxi, China.
authors.forename: F
authors.initials: F
authors.lastname: Wang
authors.affiliation: Department of Radiotherapy, Peace Hospital Attached to Changzhi Medical College, Changzhi, Shanxi, China.
authors.forename: J J
authors.initials: JJ
authors.lastname: Wu
authors.affiliation: Department of Radiotherapy, Peace Hospital Attached to Changzhi Medical College, Changzhi, Shanxi, China.
authors.forename: M
authors.initials: M
authors.lastname: Cai
mesh_terms: D000328:Adult; D000368:Aged; D044466:Asian People; D002289:Carcinoma, Non-Small-Cell Lung / Q000201:enzymology / Q000235:genetics* / Q000628:therapy; D002681:China; D002945:Cisplatin / Q000627:therapeutic use; D018572:Disease-Free Survival; D005260:Female; D056726:Genetic Association Studies; D051549:Glutathione S-Transferase pi / Q000235:genetics*; D005982:Glutathione Transferase / Q000235:genetics; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D016896:Treatment Outcome
chemical_list: D002945:Cisplatin; D051549:Glutathione S-Transferase pi; D005982:Glutathione Transferase; C413545:glutathione S-transferase T1; C496556:GSTP1 protein, human