title: Logistic ex Vivo Lung Perfusion for Hyperimmunized Patients.
abstract: Hyperimmunized patients have restricted access to lung transplantation because of the low rate of donor lung availability. Sensitization to human leukocyte antigen is associated with acute rejection, allograft dysfunction, and decreased survival. Prospective crossmatching could allow matching a lung graft with the recipient; however, such a strategy would increase graft ischemia, with a worse impact on the long-term results of lung transplantation. We used logistic ex vivo lung perfusion for 3 patients at the Foch Hospital while waiting for a negative result of the prospective crossmatching and then moved forward to lung transplantation. All patients are alive 3 years after bilateral lung transplantation.
authors.affiliation: Department of Thoracic Surgery and Lung Transplantation, Hôpital Foch, Suresnes, France.
authors.forename: Julien
authors.initials: J
authors.lastname: De Wolf
authors.affiliation: Department of Thoracic Surgery and Lung Transplantation, Hôpital Foch, Suresnes, France.
authors.forename: Philippe
authors.initials: P
authors.lastname: Puyo
authors.affiliation: Department of Thoracic Surgery and Lung Transplantation, Hôpital Foch, Suresnes, France.
authors.forename: Pierre
authors.initials: P
authors.lastname: Bonnette
authors.affiliation: Department of Pneumology, Hôpital Foch, Suresnes, France.
authors.forename: Antoine
authors.initials: A
authors.lastname: Roux
authors.affiliation: Department of Anesthesiology, Hôpital Foch, Suresnes, France.
authors.forename: Morgan
authors.initials: M
authors.lastname: Le Guen
authors.affiliation: Department of Thoracic Surgery and Lung Transplantation, Hôpital Foch, Suresnes, France.
authors.forename: François
authors.initials: F
authors.lastname: Parquin
authors.affiliation: Department of Thoracic Surgery and Lung Transplantation, Hôpital Foch, Suresnes, France.
authors.forename: Alain
authors.initials: A
authors.lastname: Chapelier
authors.affiliation: Department of Thoracic Surgery and Lung Transplantation, Hôpital Foch, Suresnes, France. Electronic address: e.sage@hopital-foch.org.
authors.forename: Edouard
authors.initials: E
authors.lastname: Sage
mesh_terms: D000328:Adult; D003550:Cystic Fibrosis / Q000175:diagnosis / Q000601:surgery; D015199:Extracorporeal Membrane Oxygenation; D005260:Female; D005500:Follow-Up Studies; D006085:Graft Survival; D006680:HLA Antigens / Q000276:immunology; D006801:Humans; D007114:Immunization / Q000009:adverse effects*; D016040:Lung Transplantation / Q000009:adverse effects / Q000379:methods*; D008875:Middle Aged; D009926:Organ Preservation / Q000379:methods*; D010477:Perfusion / Q000379:methods*; D029424:Pulmonary Disease, Chronic Obstructive / Q000175:diagnosis / Q000601:surgery; D012494:Sampling Studies; D014019:Tissue Donors; D009927:Tissue and Organ Procurement / Q000458:organization & administration*; D016896:Treatment Outcome
chemical_list: D006680:HLA Antigens