title: Mild neurological impairment may indicate a psychomotor endophenotype in patients with borderline personality disorder.
abstract: The aim of the present study was to determine whether patients with borderline personality disorder (BPD) show any neurological soft signs compared to healthy controls. Furthermore we sought to examine the role of common symptoms related to BPD, such as depression, anxiety or impulsivity, in association with neurological soft signs. Thirty patients with borderline personality disorder and thirty hospital-based controls were examined for neurological soft signs. The total score of neurological soft signs in BPD was significantly higher than controls. In terms of subscales, patients had higher scores in Sensory Integration and Motor Coordination and other neurological soft signs compared to control group. Multiple regression analysis showed that the impulsivity score was the best significant predictor of neurological soft signs in BPD. The increase of neurological soft signs in patients with BPD may address a non-focal neurological dysfunction in borderline personality disorder.
authors.affiliation: Department of Psychiatry, Psychiatry and Psychology Research Center, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Mohammad
authors.initials: M
authors.lastname: Arbabi
authors.affiliation: Neuroscience Institute, Sports Medicine Research Center, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Negin
authors.initials: N
authors.lastname: Paast
authors.affiliation: Department of Psychiatry, Psychiatry and Psychology Research Center, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Hamid Reza
authors.initials: HR
authors.lastname: Karim
authors.affiliation: Department of Psychiatry, Psychiatry and Psychology Research Center, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Sara
authors.initials: S
authors.lastname: Faghfori
authors.affiliation: Neuroscience Institute, Sports Medicine Research Center, Tehran University of Medical Sciences, Tehran, Iran. Electronic address: amirmemari@farabi.tums.ac.ir.
authors.forename: Amir Hossein
authors.initials: AH
authors.lastname: Memari
mesh_terms: D000328:Adult; D001008:Anxiety Disorders / Q000175:diagnosis / Q000523:psychology; D001883:Borderline Personality Disorder / Q000175:diagnosis* / Q000523:psychology*; D003866:Depressive Disorder / Q000175:diagnosis / Q000523:psychology; D007174:Disruptive, Impulse Control, and Conduct Disorders / Q000175:diagnosis / Q000523:psychology; D058068:Endophenotypes; D005260:Female; D006801:Humans; D008297:Male; D009422:Nervous System Diseases / Q000175:diagnosis* / Q000523:psychology*; D009460:Neurologic Examination / Q000706:statistics & numerical data; D011594:Psychometrics / Q000706:statistics & numerical data; D012016:Reference Values; D055815:Young Adult
keywords: Anxiety; Depression; Impulsivity; Neurological abnormalities; Personality disorder