title: Cholinergic agonist reverses H1-induced memory deficit in mice.
abstract: This study investigated the effects of bilateral intraamygdalar microinjections of PNU-282987, a nicotinic cholinergic agonist, on anxiety and the reversal of amnesia induced by chlorpheniramine (CPA), an H1 histaminergic antagonist, in mice subjected to the elevated plusmaze (EPM). Two experiments were performed with seventy-nine adult male Swiss mice. The isolated microinjections of PNU-282987 did not produce effects on emotional memory; however, the combined microinjections of PNU-282987 and CPA were able to reverse the deficit in memory induced by CPA (ANOVA, p<0.05). Taken together, these results suggest that intraamygdalar injections of PNU-282987 did not induce effects on anxiety and emotional memory per se; however, concurrent microinjections of PNU-282987 and CPA-reverse amnesia induced-CPA which is suggestive of an interaction between the histaminergic and cholinergic systems in the modulation of emotion memory acquisition in mice.
authors.affiliation: Laboratory of Neuroscience, Physiotherapy Department, Center of Biological Sciences and Health, Federal University of Sao Carlos, Rod. Washington Luis, Km 235, 13565-905 Sao Carlos, Brazil. Electronic address: ceduardomonici@hotmail.com.
authors.forename: C E M
authors.initials: CE
authors.lastname: Fernandes
authors.affiliation: Laboratory of Neuroscience, Physiotherapy Department, Center of Biological Sciences and Health, Federal University of Sao Carlos, Rod. Washington Luis, Km 235, 13565-905 Sao Carlos, Brazil. Electronic address: kelly.serafim@hotmail.com.
authors.forename: K R
authors.initials: KR
authors.lastname: Serafim
authors.affiliation: Laboratory of Neuroscience, Physiotherapy Department, Center of Biological Sciences and Health, Federal University of Sao Carlos, Rod. Washington Luis, Km 235, 13565-905 Sao Carlos, Brazil. Electronic address: acgianlorenco@yahoo.com.br.
authors.forename: A C L
authors.initials: AC
authors.lastname: Gianlorenço
authors.affiliation: Laboratory of Neuroscience, Physiotherapy Department, Center of Biological Sciences and Health, Federal University of Sao Carlos, Rod. Washington Luis, Km 235, 13565-905 Sao Carlos, Brazil. Electronic address: mattioli@ufscar.br.
authors.forename: R
authors.initials: R
authors.lastname: Mattioli
mesh_terms: D000679:Amygdala / Q000187:drug effects / Q000502:physiology; D000704:Analysis of Variance; D000818:Animals; D001549:Benzamides / Q000627:therapeutic use*; D001643:Bridged Bicyclo Compounds / Q000627:therapeutic use*; D002744:Chlorpheniramine / Q000633:toxicity*; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D006634:Histamine H1 Antagonists / Q000633:toxicity*; D008297:Male; D018782:Maze Learning / Q000187:drug effects; D008569:Memory Disorders / Q000139:chemically induced* / Q000188:drug therapy*; D051379:Mice; D008845:Microinjections; D018722:Nicotinic Agonists / Q000627:therapeutic use*
chemical_list: D001549:Benzamides; D001643:Bridged Bicyclo Compounds; D006634:Histamine H1 Antagonists; D018722:Nicotinic Agonists; C498513:PNU-282987; D002744:Chlorpheniramine
keywords: Amygdala; Chlorpheniramine; Elevated plus-maze; Emotional memory; PNU-282987