title: Improvement of erythema dyschromicum perstans using a combination of the 1,550-nm erbium-doped fractionated laser and topical tacrolimus ointment.
abstract: Erythema dyschromicum perstans (EDP) is a cosmetically distressing, acquired pigmentary disorder of unknown etiology for which few successful therapies exist. Herein, we present the successful use of non-ablative fractional photothermolysis in combination with topical tacrolimus ointment.
  
  
  
  A 35-year-old female with biopsy-confirmed EDP underwent a series of fractionated non-ablative treatment sessions utilizing the 1,550 nm erbium-doped fiber laser in combination with topical tacrolimus ointment over a period of 5 months.
  
  
  
  The patient's EDP improved by greater than 75% and results were maintained at the 8-month follow-up visit.
  
  
  
  The combination of non-ablative fractional photothermolysis and topical tacrolimus ointment is a potential safe and effective therapeutic option for erythema dyschromicum perstans. Additional prospective, comparative studies are warranted. Lasers Surg. Med. 49:60-62, 2017. © 2016 Wiley Periodicals, Inc.
authors.affiliation: The University of Texas Medical School at Houston, Houston, Texas.
authors.forename: Jon A
authors.initials: JA
authors.lastname: Wolfshohl
authors.affiliation: The Dermatology and Laser Surgery Center, Houston, Texas.
authors.forename: Elizabeth R C
authors.initials: ER
authors.lastname: Geddes
authors.affiliation: The Dermatology and Laser Surgery Center, Houston, Texas.
authors.forename: Ashlyn B
authors.initials: AB
authors.lastname: Stout
authors.affiliation: The Dermatology and Laser Surgery Center, Houston, Texas.|The Department of Dermatology, University of Texas Medical School at Houston, Houston, Texas.|The Department of Dermatology, Weill Cornell Medical College, Houston Methodist Hospital, Houston, Texas.
authors.forename: Paul M
authors.initials: PM
authors.lastname: Friedman
mesh_terms: D000287:Administration, Topical; D000328:Adult; D001707:Biopsy, Needle; D003131:Combined Modality Therapy; D004890:Erythema / Q000473:pathology* / Q000628:therapy*; D004954:Esthetics; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007150:Immunohistochemistry; D053844:Lasers, Solid-State / Q000627:therapeutic use*; D017512:Lichenoid Eruptions / Q000175:diagnosis / Q000628:therapy; D028022:Low-Level Light Therapy / Q000379:methods*; D017060:Patient Satisfaction / Q000706:statistics & numerical data; D012720:Severity of Illness Index; D016559:Tacrolimus / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D016559:Tacrolimus
keywords: ashy dermatosis; edp; erythema dyschromicum perstans; fraxel; laser; nonablative 1550 nm erbium-doped fractionated laser; pigment disorder; pigmentary disorder