title: Protective effects of Zygophyllum album extract against deltamethrin-induced hyperglycemia and hepato-pancreatic disorders in rats.
abstract: The current study was designed to investigate the possible mechanism involved in hyperglycemia induced by chronic exposure to deltamethrin (DLM) in rat and to assess whether this damage is amenable to modulation by Zygophyllum album. DLM, a synthetic pyrethroid pesticide, was administrated at a dose of 4 mg/kg body mass, during 60 days. Compared with control, DLM showed a significant increase of blood glucose (p ≤ 0.01) and glycosylated hemoglobin levels (p ≤ 0.01) and a clear decrease (p ≤ 0.01) of insulin and total hemoglobin levels. In addition, hepatic glycogen content and the activity of hexokinase decreased (p ≤ 0.01), whereas the activities of glucose-6-phosphatase and glycogen phosphorylase were significantly increased (p ≤ 0.01). Moreover, pancreatic lipid peroxidation (TBARS level) was higher (p ≤ 0.01) and oxidative stress biomarkers (SOD, CAT, GPx, and GSH) were altered owing to DLM toxicity. However, Z. album, when combined with DLM, significantly ameliorated almost all the hepato-pancreatic disorders induced by DLM alone. Furthermore, Z. album supplement was found to be effective in preserving the normal histological appearance of hepatic and pancreatic tissue. In conclusion, this study suggested that, owing to its antioxidant effects, methanolic extract of Z. album (MEZAL) can potentially prevent the hyperglycemia observed in DLM-treated group.
authors.affiliation: a Laboratory of Animal Ecophysiology, Faculty of Science of Sfax, 3018 Sfax, Tunisia.|b Research Unit of Macromolecular Biochemistry and Genetics, Faculty of Sciences of Gafsa, 2112 Gafsa, Tunisia.
authors.forename: Anouar
authors.initials: A
authors.lastname: Feriani
authors.affiliation: c Laboratory of Vascular Pathologies, Integrated Physiology Unit, Faculty of Sciences of Bizerte, 7021 Jarzouna, Tunisia.
authors.forename: Rafik
authors.initials: R
authors.lastname: Hachani
authors.affiliation: d Laboratory of Epidemiology and Veterinary Microbiology, Institut Pasteur de Tunis, BP 74, 1002 Belvedere-Tunis, Tunisia.
authors.forename: Belhassen
authors.initials: B
authors.lastname: Kaabi
authors.affiliation: a Laboratory of Animal Ecophysiology, Faculty of Science of Sfax, 3018 Sfax, Tunisia.
authors.forename: Marwa
authors.initials: M
authors.lastname: Ncir
authors.affiliation: a Laboratory of Animal Ecophysiology, Faculty of Science of Sfax, 3018 Sfax, Tunisia.
authors.forename: Abdelfattah
authors.initials: A
authors.lastname: El Feki
authors.affiliation: a Laboratory of Animal Ecophysiology, Faculty of Science of Sfax, 3018 Sfax, Tunisia.
authors.forename: Mohamed Salah
authors.initials: MS
authors.lastname: Allagui
keywords: Zygophyllum album; deltamethrin; deltaméthrine; hepatic; hyperglycemia; hyperglycémie; hépatique; pancreatic; pancréatique