title: Serum Galanin Levels in Young Healthy Lean and Obese Non-Diabetic Men during an Oral Glucose Tolerance Test.
abstract: Galanin (GAL) is a neuropeptide involved in the homeostasis of energy metabolism. The objective of this study was to investigate the serum levels of GAL during an oral glucose tolerance test (OGTT) in lean and obese young men. This cross-sectional study included 30 obese non-diabetic young men (median 22 years; mean BMI 37 kg/m(2)) and 30 healthy lean men (median 23 years; mean BMI 22 kg/m(2)). Serum GAL was determined during OGTT. The results of this study include that serum GAL levels showed a reduction during OGTT compared with basal levels in the lean subjects group. Conversely, serum GAL levels increased significantly during OGTT in obese subjects. Serum GAL levels were also higher in obese non-diabetic men compared with lean subjects during fasting and in every period of the OGTT (p < 0.001). Serum GAL levels were positively correlated with BMI, total fat, visceral fat, HOMA-IR, total cholesterol, triglycerides and Leptin. A multiple regression analysis revealed that serum insulin levels at 30, 60 and 120 minutes during the OGTT is the most predictive variable for serum GAL levels (p < 0.001). In conclusion, serum GAL levels are significantly higher in the obese group compared with lean subjects during an OGTT.
authors.affiliation: Department of Internal Medicine-Division of Endocrinology, School of Medicine, Universidad Nacional de Colombia, Bogotá, Colombia.
authors.forename: Héctor Fabio
authors.initials: HF
authors.lastname: Sandoval-Alzate
authors.affiliation: Department of Internal Medicine-Division of Endocrinology, School of Medicine, Universidad Nacional de Colombia, Bogotá, Colombia.
authors.forename: Yessica
authors.initials: Y
authors.lastname: Agudelo-Zapata
authors.affiliation: Department of Internal Medicine-Division of Endocrinology, School of Medicine, Universidad Nacional de Colombia, Bogotá, Colombia.
authors.forename: Angélica María
authors.initials: AM
authors.lastname: González-Clavijo
authors.affiliation: Department of Physiology, School of Medicine, Universidad Nacional de Colombia Bogotá, Colombia.
authors.forename: Natalia E
authors.initials: NE
authors.lastname: Poveda
authors.affiliation: Department of Physiology, School of Medicine, Universidad Nacional de Colombia Bogotá, Colombia.
authors.forename: Cristian Felipe
authors.initials: CF
authors.lastname: Espinel-Pachón
authors.affiliation: Department of Physiology, School of Medicine, Universidad Nacional de Colombia Bogotá, Colombia.
authors.forename: Jorge Augusto
authors.initials: JA
authors.lastname: Escamilla-Castro
authors.affiliation: Department of Physiology, School of Medicine, Universidad Nacional de Colombia Bogotá, Colombia.
authors.forename: Heidy Lorena
authors.initials: HL
authors.lastname: Márquez-Julio
authors.affiliation: Department of Physiology, School of Medicine, Universidad Nacional de Colombia Bogotá, Colombia.
authors.forename: Hernando
authors.initials: H
authors.lastname: Alvarado-Quintero
authors.affiliation: Department of Physiology, School of Medicine, Universidad Nacional de Colombia Bogotá, Colombia.
authors.forename: Fabián Guillermo
authors.initials: FG
authors.lastname: Rojas-Rodríguez
authors.affiliation: Department of Internal Medicine-Division of Endocrinology, School of Medicine, Universidad Nacional de Colombia, Bogotá, Colombia.
authors.forename: Juan Manuel
authors.initials: JM
authors.lastname: Arteaga-Díaz
authors.affiliation: Institute of Clinical Investigations, School of Medicine, Universidad Nacional de Colombia, Bogotá, Colombia.
authors.forename: Javier Hernando
authors.initials: JH
authors.lastname: Eslava-Schmalbach
authors.affiliation: Department of Physiology, School of Medicine, Universidad Nacional de Colombia Bogotá, Colombia.
authors.forename: Maria Fernanda
authors.initials: MF
authors.lastname: Garcés-Gutiérrez
authors.affiliation: Department of Human Anatomy &Cell Science, Faculty of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada.
authors.forename: Maria
authors.initials: M
authors.lastname: Vrontakis
authors.affiliation: Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC), Córdoba, Spain.|Department of Cell Biology, Physiology, and Immunology, University of Córdoba, Córdoba, Spain.|Hospital Universitario Reina Sofía, Córdoba, Spain.|CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Spain.
authors.forename: Justo P
authors.initials: JP
authors.lastname: Castaño
authors.affiliation: Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC), Córdoba, Spain.|Department of Cell Biology, Physiology, and Immunology, University of Córdoba, Córdoba, Spain.|Hospital Universitario Reina Sofía, Córdoba, Spain.|CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Spain.
authors.forename: Raul M
authors.initials: RM
authors.lastname: Luque
authors.affiliation: Department of Physiology (CIMUS), School of Medicine, University of Santiago de Compostela, Santiago de Compostela, Spain.|Instituto de Investigaciones Sanitarias (IDIS), University of Santiago de Compostela, Santiago de Compostela, Spain.|CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Spain.
authors.forename: Carlos
authors.initials: C
authors.lastname: Diéguez
authors.affiliation: Department of Physiology (CIMUS), School of Medicine, University of Santiago de Compostela, Santiago de Compostela, Spain.|Instituto de Investigaciones Sanitarias (IDIS), University of Santiago de Compostela, Santiago de Compostela, Spain.|CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Spain.
authors.forename: Rubén
authors.initials: R
authors.lastname: Nogueiras
authors.affiliation: Department of Physiology, School of Medicine, Universidad Nacional de Colombia Bogotá, Colombia.
authors.forename: Jorge E
authors.initials: JE
authors.lastname: Caminos
mesh_terms: D000328:Adult; D001786:Blood Glucose / Q000378:metabolism; D015992:Body Mass Index; D003430:Cross-Sectional Studies; D019004:Galanin / Q000097:blood*; D005951:Glucose Tolerance Test / Q000379:methods*; D006801:Humans; D007328:Insulin / Q000097:blood; D008297:Male; D009765:Obesity / Q000097:blood* / Q000503:physiopathology; D012044:Regression Analysis; D055815:Young Adult
chemical_list: D001786:Blood Glucose; D007328:Insulin; D019004:Galanin