title: Role of Envelopment in the HEV Life Cycle.
abstract: Hepatitis E virus (HEV), an enterically transmitted hepatotropic virus, was thought to be non-enveloped for decades. However, recent studies have revealed that the virus circulating in the patient's blood is completely cloaked in host membranes and resistant to neutralizing antibodies. The discovery of this novel enveloped form of HEV has raised a series of questions about the fundamental biology of HEV and the way this virus, which has been understudied in the past, interacts with its host. Here, we review recent advances towards understanding this phenomenon and discuss its potential impact on various aspects of the HEV life cycle and immunity.
authors.affiliation: Center for Vaccines and Immunity, The Research Institute at Nationwide Children's Hospital, Columbus, OH 43205, USA. xin.yin@nationwidechildrens.org.
authors.forename: Xin
authors.initials: X
authors.lastname: Yin
authors.affiliation: Center for Vaccines and Immunity, The Research Institute at Nationwide Children's Hospital, Columbus, OH 43205, USA. xinlei.li@nationwidechildrens.org.
authors.forename: Xinlei
authors.initials: X
authors.lastname: Li
authors.affiliation: Center for Vaccines and Immunity, The Research Institute at Nationwide Children's Hospital, Columbus, OH 43205, USA. zongdi.feng@nationwidechildrens.org.|Department of Pediatrics, The Ohio State University College of Medicine, Columbus, OH 43205, USA. zongdi.feng@nationwidechildrens.org.
authors.forename: Zongdi
authors.initials: Z
authors.lastname: Feng
mesh_terms: D000818:Animals; D016752:Hepatitis E virus / Q000502:physiology* / Q000648:ultrastructure*; D054884:Host-Pathogen Interactions; D006801:Humans; D008954:Models, Biological; D056224:Viral Structures; D019065:Virus Assembly
keywords: hepatitis E virus; quasi-envelopment