title: Evaluation of pulsing magnetic field effects on paresthesia in multiple sclerosis patients, a randomized, double-blind, parallel-group clinical trial.
abstract: OBJECTIVE
  Evidence is mounting that magnet therapy could alleviate the symptoms of multiple sclerosis (MS). This study was performed to test the effects of the pulsing magnetic fields on the paresthesia in MS patients.
  
  
  METHODS
  This study has been conducted as a randomized, double-blind, parallel-group clinical trial during the April 2012 to October 2013. The subjects were selected among patients referred to MS clinic of Imam Reza Hospital; affiliated to Kermanshah University of Medical Sciences, Iran. Sixty three patients with MS were included in the study and randomly were divided into two groups, 35 patients were exposed to a magnetic pulsing field of 4mT intensity and 15-Hz frequency sinusoidal wave for 20min per session 2 times per week over a period of 2 months involving 16 sessions and 28 patients was exposed to a magnetically inactive field (placebo) for 20min per session 2 times per week over a period of 2 months involving 16 sessions. The severity of paresthesia was measured by the numerical rating scale (NRS) at 30, 60days. The study primary end point was NRS change between baseline and 60days. The secondary outcome was NRS change between baseline and 30days.
  
  
  RESULTS
  Patients exposing to magnetic field showed significant paresthesia improvement compared with the group of patients exposing to placebo.
  
  
  CONCLUSIONS
  According to our results pulsed magnetic therapy could alleviate paresthesia in MS patients .But trials with more patients and longer duration are mandatory to describe long-term effects.
authors.affiliation: Department of Neurology, Imam Reza Hospital, College of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Islamic Republic of Iran.
authors.forename: Daryoush
authors.initials: D
authors.lastname: Afshari
authors.affiliation: Department of Neurology, Imam Reza Hospital, College of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Islamic Republic of Iran. Electronic address: moradiannasrin60@yahoo.com.
authors.forename: Nasrin
authors.initials: N
authors.lastname: Moradian
authors.affiliation: Department of Neurology, Imam Reza Hospital, College of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Islamic Republic of Iran.
authors.forename: Majid
authors.initials: M
authors.lastname: Khalili
authors.affiliation: Department of Neurology, Imam Reza Hospital, College of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Islamic Republic of Iran.
authors.forename: Nazanin
authors.initials: N
authors.lastname: Razazian
authors.affiliation: Department of Neurology, Imam Reza Hospital, College of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Islamic Republic of Iran.
authors.forename: Arash
authors.initials: A
authors.lastname: Bostani
authors.affiliation: Department of Biostatistics & Epidemiology, Kermanshah University of Medical Science, Kermanshah, Islamic Republic of Iran.
authors.forename: Jamal
authors.initials: J
authors.lastname: Hoseini
authors.affiliation: Department of Neurology, Imam Reza Hospital, College of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Islamic Republic of Iran.
authors.forename: Mohamad
authors.initials: M
authors.lastname: Moradian
authors.affiliation: Department of Neurology, Hamadan University of Medical Sciences and Health Services, Hamadan, Islamic Republic of Iran.
authors.forename: Masoud
authors.initials: M
authors.lastname: Ghiasian
mesh_terms: D000328:Adult; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D055909:Magnetic Field Therapy / Q000379:methods*; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000150:complications*; D010292:Paresthesia / Q000209:etiology / Q000628:therapy*; D016896:Treatment Outcome
keywords: Magnet therapy; Multiple sclerosis; Paresthesia