title: Knowns and Known Unknowns of Gastrointestinal Stromal Tumor Adjuvant Therapy.
abstract: The first 15 years of management of gastrointestinal stromal tumor (GIST) have led to 3 lines of therapy for metastatic disease: imatinib, sunitinib, and regorafenib. In the adjuvant setting, imatinib is usually given for 3 years postoperatively to patients with higher-risk primary tumors that are completely resected. In this review, issues regarding GIST adjuvant therapy are discussed. It is hoped this review will help the reader understand the present standard of care to improve upon it in years to come.
authors.affiliation: Medical Oncology Service, Hospital Universitario La Paz, P° de la Castellana, 261, Madrid 28046, Spain.
authors.forename: Virginia
authors.initials: V
authors.lastname: Martínez-Marín
authors.affiliation: Tisch Cancer Institute, Department of Medicine, Mt Sinai Medical Center, 1 Gus Levy Place, New York, NY 10029-6574, USA. Electronic address: robert.maki@mssm.edu.
authors.forename: Robert G
authors.initials: RG
authors.lastname: Maki
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use*; D017024:Chemotherapy, Adjuvant; D013505:Digestive System Surgical Procedures; D005770:Gastrointestinal Neoplasms / Q000188:drug therapy* / Q000235:genetics; D046152:Gastrointestinal Stromal Tumors / Q000188:drug therapy* / Q000235:genetics; D006801:Humans; D000068877:Imatinib Mesylate / Q000627:therapeutic use*; D007211:Indoles / Q000627:therapeutic use; D009154:Mutation; D020360:Neoadjuvant Therapy; D010671:Phenylurea Compounds / Q000627:therapeutic use; D019009:Proto-Oncogene Proteins c-kit / Q000235:genetics; D011725:Pyridines / Q000627:therapeutic use; D011758:Pyrroles / Q000627:therapeutic use; D020796:Receptor, Platelet-Derived Growth Factor alpha / Q000235:genetics; D000077210:Sunitinib
chemical_list: D000970:Antineoplastic Agents; D007211:Indoles; D010671:Phenylurea Compounds; D011725:Pyridines; D011758:Pyrroles; C559147:regorafenib; D000068877:Imatinib Mesylate; D019009:Proto-Oncogene Proteins c-kit; D020796:Receptor, Platelet-Derived Growth Factor alpha; D000077210:Sunitinib
keywords: Adjuvant therapy; Gastrointestinal stromal tumor (GIST); Imatinib; KIT mutation; PDGFRA mutation