title: Change in serum TSH levels within the reference range was associated with variation of future blood pressure: a 5-year follow-up study.
abstract: Controversy exists on the relationship between serum thyrotropin (TSH) and blood pressure, and only a few prospective studies are available up to now. The study aimed to investigate the association between serum TSH within the reference range and blood pressure through a 5-year follow-up study. A total of 623 subjects with normal TSH were followed up for 5 years, including the measurement of demographic data, blood pressure, height, weight and serum TSH. Finally, 531 subjects were included in this prospective study. Body mass index (BMI), prevalence of hypertension, and systolic and diastolic blood pressure were all higher at follow-up than at baseline. Adjusted for age, gender, smoking status, BMI and homoeostasis model assessment of insulin resistance (HOMA-IR) at baseline, multiple linear regression analyses found no relationship between serum TSH at baseline and levels of blood pressure at follow-up, but the changes in serum TSH levels during follow-up was positively associated with the changes in systolic blood pressure (B=2.134, P<0.05), which became more significant in women but not significant in men. The change of systolic blood pressure in group of TSH increase >0.5 mIU l-1was significantly higher than in group of TSH decrease >0.5 mIU l-1within reference, after adjusting for age, gender, smoking status, BMI and HOMA-IR at baseline. This result became more significant in women, but no statistical significance was observed in men. Co-variation with serum TSH levels and blood pressure was observed during 5-year follow-up among people with normal TSH.
authors.affiliation: Department of Endocrinology and Metabolism and the Institute of Endocrinology of the First Affiliated Hospital, China Medical University, Shenyang, PR China.
authors.forename: F
authors.identifier: 0000-0002-4021-5562
authors.initials: F
authors.lastname: Jiang
authors.affiliation: Department of Endocrinology and Metabolism and the Institute of Endocrinology of the First Affiliated Hospital, China Medical University, Shenyang, PR China.
authors.forename: A
authors.initials: A
authors.lastname: Liu
authors.affiliation: Department of Endocrinology and Metabolism and the Institute of Endocrinology of the First Affiliated Hospital, China Medical University, Shenyang, PR China.
authors.forename: Y
authors.initials: Y
authors.lastname: Lai
authors.affiliation: Department of Endocrinology and Metabolism and the Institute of Endocrinology of the First Affiliated Hospital, China Medical University, Shenyang, PR China.
authors.forename: X
authors.initials: X
authors.lastname: Yu
authors.affiliation: Department of Endocrinology and Metabolism and the Institute of Endocrinology of the First Affiliated Hospital, China Medical University, Shenyang, PR China.
authors.forename: C
authors.initials: C
authors.lastname: Li
authors.affiliation: Department of Endocrinology and Metabolism and the Institute of Endocrinology of the First Affiliated Hospital, China Medical University, Shenyang, PR China.
authors.forename: C
authors.initials: C
authors.lastname: Han
authors.affiliation: Department of Endocrinology and Metabolism and the Institute of Endocrinology of the First Affiliated Hospital, China Medical University, Shenyang, PR China.
authors.forename: Y
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Department of Endocrinology and Metabolism and the Institute of Endocrinology of the First Affiliated Hospital, China Medical University, Shenyang, PR China.
authors.forename: X
authors.initials: X
authors.lastname: Wang
authors.affiliation: Department of Endocrinology and Metabolism and the Institute of Endocrinology of the First Affiliated Hospital, China Medical University, Shenyang, PR China.
authors.forename: Z
authors.initials: Z
authors.lastname: Wang
authors.affiliation: Department of Endocrinology and Metabolism and the Institute of Endocrinology of the First Affiliated Hospital, China Medical University, Shenyang, PR China.
authors.forename: S
authors.initials: S
authors.lastname: Bao
authors.affiliation: Department of Endocrinology and Metabolism and the Institute of Endocrinology of the First Affiliated Hospital, China Medical University, Shenyang, PR China.
authors.forename: N
authors.initials: N
authors.lastname: Lv
authors.affiliation: Department of Endocrinology and Metabolism and the Institute of Endocrinology of the First Affiliated Hospital, China Medical University, Shenyang, PR China.
authors.forename: M
authors.initials: M
authors.lastname: Jin
authors.affiliation: Department of Endocrinology and Metabolism and the Institute of Endocrinology of the First Affiliated Hospital, China Medical University, Shenyang, PR China.
authors.forename: F
authors.initials: F
authors.lastname: Yang
authors.affiliation: Department of Endocrinology and Metabolism and the Institute of Endocrinology of the First Affiliated Hospital, China Medical University, Shenyang, PR China.
authors.forename: Y
authors.initials: Y
authors.lastname: Fan
authors.affiliation: Department of Endocrinology and Metabolism and the Institute of Endocrinology of the First Affiliated Hospital, China Medical University, Shenyang, PR China.
authors.forename: T
authors.initials: T
authors.lastname: Jin
authors.affiliation: Department of Endocrinology and Metabolism and the Institute of Endocrinology of the First Affiliated Hospital, China Medical University, Shenyang, PR China.
authors.forename: W
authors.initials: W
authors.lastname: Zhao
authors.affiliation: Department of Endocrinology and Metabolism and the Institute of Endocrinology of the First Affiliated Hospital, China Medical University, Shenyang, PR China.
authors.forename: Z
authors.initials: Z
authors.lastname: Shan
authors.affiliation: Department of Endocrinology and Metabolism and the Institute of Endocrinology of the First Affiliated Hospital, China Medical University, Shenyang, PR China.
authors.forename: W
authors.initials: W
authors.lastname: Teng
mesh_terms: D000328:Adult; D001794:Blood Pressure; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D013972:Thyrotropin / Q000097:blood*
chemical_list: D013972:Thyrotropin