title: Regulation of oncogenic genes by MicroRNAs and pseudogenes in human lung cancer.
abstract: Lung cancer is one of the most common mortal cancer types both for men and women. Several different biomarkers have been analyzed to reveal lung cancer prognosis pathways for developing efficient therapeutics and diagnostic agents. microRNAs (miRNAs) and pseudogenes are critical biomarkers in lung cancer and alteration of their expression levels has been identified in each step of lung cancer tumorigenesis. miRNAs and pseudogenes are crucial gene regulators in normal cells as well as in lung cancer cells, and they have both oncogenic and tumor-suppressive roles in lung cancer tumorigenesis. In this study, we have determined the relationship between lung cancer related oncogenes and miRNAs along with pseudogenes in lung cancer, and the results indicate their potential as biological markers for diagnostic and therapeutic purposes.
authors.affiliation: Cumhuriyet University, Faculty of Pharmacy, Department of Basic Sciences, Division of Biochemistry, Sivas, Turkey. Electronic address: ytutar@cumhuriyet.edu.tr.
authors.forename: Yusuf
authors.initials: Y
authors.lastname: Tutar
authors.affiliation: Gaziosmanpaşa University, Faculty of Natural Sciences and Engineering, Department of Bioengineering, Tokat, Turkey.
authors.forename: Aykut
authors.initials: A
authors.lastname: Özgür
authors.affiliation: Kahramanmaraş Sütçü İmam University, Graduate School of Natural and Applied Sciences, Department of Bioengineering and Sciences, Kahramanmaraş, Turkey.
authors.forename: Esen
authors.initials: E
authors.lastname: Tutar
authors.affiliation: Kahramanmaraş Sütçü İmam University, Faculty of Science and Letters, Department of Biology, Kahramanmaraş, Turkey.
authors.forename: Lütfi
authors.initials: L
authors.lastname: Tutar
authors.affiliation: Department of Health Sciences, University of Genoa, Italy.
authors.forename: Alessandra
authors.initials: A
authors.lastname: Pulliero
authors.affiliation: Department of Health Sciences, University of Genoa, Italy; Mutagenesis Unit, IRCCS University Hospital San Martino-IST, National Institute for Cancer Research, Genoa, Italy.
authors.forename: Alberto
authors.initials: A
authors.lastname: Izzotti
mesh_terms: D014408:Biomarkers, Tumor / Q000502:physiology*; D063646:Carcinogenesis / Q000235:genetics / Q000378:metabolism; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics* / Q000378:metabolism; D008297:Male; D035683:MicroRNAs / Q000502:physiology*; D009857:Oncogenes / Q000502:physiology*; D011544:Pseudogenes / Q000502:physiology*
chemical_list: D014408:Biomarkers, Tumor; D035683:MicroRNAs
keywords: Biomarker; Lung cancer; Pseudogene; miRNA; miRNA therapeutics