title: Total synthesis of fellutamides, lipopeptide proteasome inhibitors. More sustainable peptide bond formation.
abstract: Solution-phase syntheses of three bioactive natural products of mixed polypeptide-polyketide biogenesis, fellutamides A, B, and C, have been achieved. Three peptide bonds are generated without the use of coupling reagents in each synthesis of the fellutamides, which act against proteasomes.
authors.affiliation: Department of Chemistry, University of California, Riverside, CA 92521, USA.
authors.forename: Michael C
authors.initials: MC
authors.lastname: Pirrung
authors.forename: Fa
authors.initials: F
authors.lastname: Zhang
authors.forename: Sudhakar
authors.initials: S
authors.lastname: Ambadi
authors.forename: Y
authors.initials: Y
authors.lastname: Gangadhara Rao
mesh_terms: D001688:Biological Products / Q000737:chemistry; D060326:Chemistry Techniques, Synthetic / Q000379:methods*; D055666:Lipopeptides / Q000138:chemical synthesis*; D015394:Molecular Structure; D009842:Oligopeptides / Q000138:chemical synthesis; D061988:Proteasome Inhibitors / Q000138:chemical synthesis*; D012996:Solutions / Q000737:chemistry
chemical_list: D001688:Biological Products; D055666:Lipopeptides; D009842:Oligopeptides; D061988:Proteasome Inhibitors; D012996:Solutions; C513652:fellutamide B; C562120:fellutamide C; C080556:fellutamide A