title: Increased serum GDF11 concentration is associated with a high prevalence of osteoporosis in elderly native Chinese women.
abstract: Osteoporosis is an age-related disease. Many studies have confirmed the anti-aging effect of growth differentiation factor 11 (GDF11), but the action of GDF11 on bone metabolism remains unclear. In this study, we aimed to investigate the relationship between serum GDF11 levels and the prevalence of osteoporosis. Our data indicate negative correlations between serum GDF11 levels and BMD at the lumbar spine and femoral neck. The serum GDF11 levels were grouped into quartile intervals, and the prevalence and risk of osteoporosis were found be markedly greater with increased GDF11 levels. This study demonstrated that GDF11 was negatively correlated with BMD in elderly Chinese women. Furthermore, osteoporotic risk was significantly increased with increases in GDF11 levels.
authors.affiliation: Department of Orthopedics, The Xiangya Hospital of Central South University, Changsha, Hunan, China.|Department of Endocrinology, The Heji Affiliated Hospital of Changzhi Medical College, Changsha, Hunan, China.
authors.forename: Miaomiao
authors.initials: M
authors.lastname: Jin
authors.affiliation: Department of Endocrinology, The Xiangya Hospital of Central South University, Changsha, Hunan, China.
authors.forename: Shumin
authors.initials: S
authors.lastname: Song
authors.affiliation: Department of Endocrinology, The Xiangya Hospital of Central South University, Changsha, Hunan, China.
authors.forename: Lijuan
authors.initials: L
authors.lastname: Guo
authors.affiliation: Department of Endocrinology, The Xiangya Hospital of Central South University, Changsha, Hunan, China.
authors.forename: Tiejian
authors.initials: T
authors.lastname: Jiang
authors.affiliation: Department of Orthopedics, The Xiangya Hospital of Central South University, Changsha, Hunan, China. zhangyuanlin1605@163.com.
authors.forename: Zhang-Yuan
authors.initials: ZY
authors.lastname: Lin
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000097:blood*; D044466:Asian People; D015415:Biomarkers / Q000097:blood; D015519:Bone Density / Q000502:physiology; D019485:Bone Morphogenetic Proteins / Q000097:blood*; D005260:Female; D055412:Growth Differentiation Factors / Q000097:blood*; D006801:Humans; D008875:Middle Aged; D010024:Osteoporosis / Q000097:blood* / Q000175:diagnosis / Q000453:epidemiology*; D015995:Prevalence
chemical_list: D015415:Biomarkers; D019485:Bone Morphogenetic Proteins; C492266:GDF11 protein, human; D055412:Growth Differentiation Factors
keywords: ageing; elderly women; growth differentiation factor 11; osteoporosis