title: The topography of cortical microbleeds in frontotemporal lobar degeneration: a post-mortem 7.0-tesla magnetic resonance study.
abstract: BACKGROUND
  Cerebrovascular lesions are rare in frontotemporal lobar degeneration (FTLD), in contrast to other neurodegenerative diseases. Cortical microbleeds (CoMBs) are frequent in Alzheimer's disease, in particular in cases associated with cerebral amyloid angiopathy. The present study investigates the gyral topographic distribution of CoMBs in post-mortem FTLD brains with 7.0-tesla magnetic resonance imaging.
  
  
  METHODS
  The distribution of CoMBs in 11 post-mortem FTLD brains and in 12 control brains was compared on T2*-GRE MRI of six coronal sections of a cerebral hemisphere. The mean values of CoMBs were determined in twenty-two different gyri. The findings were correlated to those separately observed on neuropathological examination.
  
  
  RESULTS
  As a whole there was a trend of more CoMBs in the prefrontal section of FTLD as well as of the control brains. CoMBs were significantly increased in the superior frontal gyrus and the insular cortex (p ≤ 0.001) and also in the inferior frontal gyrus and the superior temporal gyrus (p ≤ 0.01).
  
  
  CONCLUSIONS
  CoMBs in FTLD are only increased in the regions mainly affected by the neurodegenerative lesions. They probably do not reflect additional cerebrovascular disease.
authors.affiliation: J.L. De Reuck, Leopold II laan 96, BE-9000, Ghent, Belgium, phone: +32 9 2218844, fax: +32 9 3324971, e-mail: dereuck.j@gmail.com.
authors.forename: J
authors.initials: J
authors.lastname: De Reuck
authors.forename: F
authors.initials: F
authors.lastname: Auger
authors.forename: N
authors.initials: N
authors.lastname: Durieux
authors.forename: V
authors.initials: V
authors.lastname: Deramecourt
authors.forename: C-A
authors.initials: CA
authors.lastname: Maurage
authors.forename: F
authors.initials: F
authors.lastname: Lebert
authors.forename: D
authors.initials: D
authors.lastname: Leys
authors.forename: C
authors.initials: C
authors.lastname: Cordonnier
authors.forename: F
authors.initials: F
authors.lastname: Pasquier
authors.forename: R
authors.initials: R
authors.lastname: Bordet
mesh_terms: D000544:Alzheimer Disease / Q000473:pathology; D001344:Autopsy / Q000379:methods; D016657:Cerebral Amyloid Angiopathy / Q000150:complications / Q000175:diagnosis / Q000473:pathology*; D002543:Cerebral Hemorrhage / Q000175:diagnosis / Q000473:pathology*; D005260:Female; D057174:Frontotemporal Lobar Degeneration / Q000175:diagnosis / Q000473:pathology*; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D008297:Male; D008875:Middle Aged