title: Four New Dicaffeoylquinic Acid Derivatives from Glasswort (Salicornia herbacea L.) and Their Antioxidative Activity.
abstract: Four new dicaffeoylquinic acid derivatives and two known 3-caffeoylquinic acid derivatives were isolated from methanol extracts using the aerial parts of Salicornia herbacea. The four new dicaffeoylquinic acid derivatives were established as 3-caffeoyl-5-dihydrocaffeoylquinic acid, 3-caffeoyl-5-dihydrocaffeoylquinic acid methyl ester, 3-caffeoyl-4-dihydrocaffeoylquinic acid methyl ester, and 3,5-di-dihydrocaffeoylquinic acid methyl ester. Their chemical structures were determined by nuclear magnetic resonance and electrospray ionization-mass spectroscopy (LC-ESI-MS). In addition, the presence of dicaffeoylquinic acid derivatives in this plant was reconfirmed by LC-ESI-MS/MS analysis. The isolated compounds strongly scavenged 1,1-diphenyl-2-picrylhydrazyl radicals and inhibited cholesteryl ester hydroperoxide formation during rat blood plasma oxidation induced by copper ions. These results indicate that the caffeoylquinic acid derivatives may partially contribute to the antioxidative effect of S. herbacea.
authors.affiliation: Department of Food Science and Technology and Functional Food Research Center, BK21 Plus Program, and Chonnam National University, Gwangju 61186, Korea. jyongcho@mokpo.ac.kr.|Department of Food Engineering and Solar Salt Research Center, Mokpo National University, Jeonnam 58554, Korea. jyongcho@mokpo.ac.kr.
authors.forename: Jeong-Yong
authors.initials: JY
authors.lastname: Cho
authors.affiliation: Department of Food Science and Technology and Functional Food Research Center, BK21 Plus Program, and Chonnam National University, Gwangju 61186, Korea. jykim78@korea.kr.|Jeollanam-Do Institute of Health and Environment, Jeonnam 58568, Korea. jykim78@korea.kr.
authors.forename: Jin Young
authors.initials: JY
authors.lastname: Kim
authors.affiliation: Department of Food Science and Technology and Functional Food Research Center, BK21 Plus Program, and Chonnam National University, Gwangju 61186, Korea. ugun2@naver.com.
authors.forename: Yu Geon
authors.initials: YG
authors.lastname: Lee
authors.affiliation: Department of Food Science and Technology and Functional Food Research Center, BK21 Plus Program, and Chonnam National University, Gwangju 61186, Korea. leehj79@port.kobe-u.ac.jp.
authors.forename: Hyoung Jae
authors.initials: HJ
authors.lastname: Lee
authors.affiliation: Department of Food Science and Technology and Functional Food Research Center, BK21 Plus Program, and Chonnam National University, Gwangju 61186, Korea. shj1004v@naver.com.
authors.forename: Hyun Jeong
authors.initials: HJ
authors.lastname: Shim
authors.affiliation: Department of Food Science and Technology and Functional Food Research Center, BK21 Plus Program, and Chonnam National University, Gwangju 61186, Korea. psk9896@naver.com.
authors.forename: Ji Hye
authors.initials: JH
authors.lastname: Lee
authors.affiliation: Department of Marine Bio Food Science, Chonnam National University, Yeosu 59626, Korea. foodkims@jnu.ac.kr.
authors.forename: Seon-Jae
authors.initials: SJ
authors.lastname: Kim
authors.affiliation: Department of Food Engineering and Solar Salt Research Center, Mokpo National University, Jeonnam 58554, Korea. ksham@mokpo.ac.kr.
authors.forename: Kyung-Sik
authors.initials: KS
authors.lastname: Ham
authors.affiliation: Department of Food Science and Technology and Functional Food Research Center, BK21 Plus Program, and Chonnam National University, Gwangju 61186, Korea. nutrmoon@jnu.ac.kr.
authors.forename: Jae-Hak
authors.initials: JH
authors.lastname: Moon
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D019663:Chenopodiaceae / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D015394:Molecular Structure; D018384:Oxidative Stress / Q000187:drug effects; D035261:Plant Components, Aerial / Q000737:chemistry; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D010949:Plasma / Q000737:chemistry / Q000187:drug effects*; D011801:Quinic Acid / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology; D051381:Rats; D021241:Spectrometry, Mass, Electrospray Ionization
chemical_list: D000975:Antioxidants; D010936:Plant Extracts; C472707:caffeoylquinic acid; D011801:Quinic Acid
keywords: Salicornia herbacea; antioxidant; blood plasma oxidation; caffeoylquinic acid derivatives; radical-scavenging activity