title: The impact of moderate distance recreational running and ageing on cardiac physiology.
abstract: Exercise-induced cardiac dysfunction and corollary biomarker release have been documented following long-distance running events. To what degree these processes occur during shorter distance running events is unknown.
  
  
  
  72 healthy recreational runners (54% male/46% female) recruited by age (group 1 (18-20 years old, N=19); group 2 (45-50 years old, N=27); group 3 (70-75 years old, N=26)) were studied with echocardiography and biochemical profiling during participation in a 10 km running race.
  
  
  
  Despite age-dependent baseline differences in ventricular size and diastolic tissue velocities, there were no significant within group or across group decrements in ventricular systolic or diastolic function following race completion. Postrace increases in cardiac troponin-I (cTnI), B-type natriuretic peptide (BNP) and high-sensitivity C-reactive protein (hs-CRP) were common and demonstrated distinct age dependent profiles. Specifically, BNP increases were most pronounced among older runners (group 3Δ: 16±22 pg/mL, p=0.001), hs-CRP increased only among younger runners (group 1Δ: 1.5±2.7 mg/L, p=0.03) and cTnI increased in both younger (group 1Δ: 0.01±0.02 ng/mL, p=0.028) and older (group 3Δ: 0.01±0.01 ng/mL, p=0.007) runners, but not middle aged runners (group 2Δ: 0.00±0.00 ng/mL, p=0.57).
  
  
  
  Moderate distance recreational running leads to distinct age-dependent biomarker release but is not associated with cardiac fatigue, a proposed stimulus for pathologic cardiac remodelling that has been observed following longer distance running events.
authors.affiliation: Division of Cardiology, Emory Clinical Cardiovascular Research Institute, Atlanta, Georgia, USA.|Atlanta Track Club, Atlanta, Georgia, USA.
authors.forename: Jonathan H
authors.initials: JH
authors.lastname: Kim
authors.affiliation: Department of Biostatistics and Bioinformatics, Emory University, Atlanta, Georgia, USA.
authors.forename: Yi-An
authors.initials: YA
authors.lastname: Ko
authors.affiliation: Division of Cardiology, Emory Clinical Cardiovascular Research Institute, Atlanta, Georgia, USA.
authors.forename: Jeff
authors.initials: J
authors.lastname: Hedley
authors.affiliation: Division of Cardiology, Emory Clinical Cardiovascular Research Institute, Atlanta, Georgia, USA.
authors.forename: James
authors.initials: J
authors.lastname: MacNamara
authors.affiliation: Division of Cardiology, Emory Clinical Cardiovascular Research Institute, Atlanta, Georgia, USA.
authors.forename: Mosaab
authors.initials: M
authors.lastname: Awad
authors.affiliation: Division of Cardiology, Emory Clinical Cardiovascular Research Institute, Atlanta, Georgia, USA.
authors.forename: William
authors.initials: W
authors.lastname: Taylor
authors.affiliation: Division of Cardiology, Emory Clinical Cardiovascular Research Institute, Atlanta, Georgia, USA.
authors.forename: Sean
authors.initials: S
authors.lastname: Healy
authors.affiliation: Division of Cardiology, Emory Clinical Cardiovascular Research Institute, Atlanta, Georgia, USA.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Aida
authors.affiliation: Biomarker Core Laboratory, Veterans' Affairs Medical Center, Atlanta, Georgia, USA.
authors.forename: Ngoc-Anh
authors.initials: NA
authors.lastname: Le
authors.affiliation: Division of Cardiology, Emory Clinical Cardiovascular Research Institute, Atlanta, Georgia, USA.|Biomarker Core Laboratory, Veterans' Affairs Medical Center, Atlanta, Georgia, USA.
authors.forename: Peter W
authors.initials: PW
authors.lastname: Wilson
authors.affiliation: Department of Emergency Medicine, Emory University, Atlanta, Georgia, USA.
authors.forename: Melissa
authors.initials: M
authors.lastname: White
authors.affiliation: Division of Cardiology, Emory Clinical Cardiovascular Research Institute, Atlanta, Georgia, USA.
authors.forename: Laurence S
authors.initials: LS
authors.lastname: Sperling
authors.affiliation: Atlanta Track Club, Atlanta, Georgia, USA.
authors.forename: Joseph S
authors.initials: JS
authors.lastname: Wilson
authors.affiliation: Cardiovascular Performance Program, Massachusetts General Hospital, Boston, Massachusetts, USA.
authors.forename: Aaron L
authors.initials: AL
authors.lastname: Baggish
mesh_terms: D000222:Adaptation, Physiological; D000293:Adolescent; D000367:Age Factors; D000368:Aged; D000375:Aging / Q000097:blood; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000378:metabolism; D059267:Cardiomegaly, Exercise-Induced; D015150:Echocardiography, Doppler; D004562:Electrocardiography; D005260:Female; D006321:Heart / Q000000981:diagnostic imaging / Q000502:physiology*; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D020097:Natriuretic Peptide, Brain / Q000097:blood; D010807:Physical Endurance; D011446:Prospective Studies; D012420:Running; D019210:Troponin I / Q000097:blood; D016277:Ventricular Function, Left
chemical_list: D015415:Biomarkers; D019210:Troponin I; D020097:Natriuretic Peptide, Brain; D002097:C-Reactive Protein