title: Antibiotic treatment and resistance in chronic wounds of vascular origin.
abstract: OBJECTIVE
  The problem of antibiotic resistance is worldwide and affects many types of pathogens. This phenomenon has been growing for decades and nowadays we are faced with a wide range of worrisome pathogens that are becoming resistant and many pathogens that may soon be untreatable. The aim of this study was to determine the resistance and antibiotic treatment in chronic wounds of vascular origin.
  
  
  METHODS
  We performed a cross sectional study on a sample of patients with chronic vascular wounds, hospitalized between October 2014 and August 2015, in the Clinic of Vascular Surgery in Trakia Hospital Stara Zagora. The statistical analysis of data was descriptive, considering the p value of ≤0.05, the threshold of statistical significance.
  
  
  RESULTS
  In the group of 110 patients, the significantly most frequent chronic wound (p<0.001) was peripheral arteriopathy (47.3%, CI95%: 38.19-56.54). Among 159 strains, 30% of patients having multiple etiology, the species most frequently isolated were Staphylococcus aureus, E.coli, Enterococcus faecalis, Pseudomonas aeruginosa and Proteus mirabilis with a significant predominance (p<0.05) of the Gram negative (55.1%). The spectrum of strains resistance included the Beta-lactams (36.4%, p<0.001), Macrolides (20%), Tetracyclines (9.1%), Aminoglycosides (8.2%) and Fluoroquinolones (4.5%).
  
  
  CONCLUSIONS
  Gram negative microorganisms were the main isolates in patients with vascular chronic wound. Significantly predominant was the resistance to the beta-lactam antibiotics.
authors.affiliation: MHAT Trakia, Stara Zagora, Bulgaria.
authors.forename: Valentina
authors.initials: V
authors.lastname: Tzaneva
authors.affiliation: Trakia University Stara Zagora, Bulgaria.
authors.forename: Irena
authors.initials: I
authors.lastname: Mladenova
authors.affiliation: MHAT Trakia, Stara Zagora, Bulgaria.
authors.forename: Galina
authors.initials: G
authors.lastname: Todorova
authors.affiliation: MHAT Trakia, Stara Zagora, Bulgaria.
authors.forename: Dimitar
authors.initials: D
authors.lastname: Petkov
keywords: antibiotic resistance; antibiotic treatment; vascular chronic wounds