title: Investigation of the Etiology of Central Serous Chorioretinopathy Using En-Face Optical Coherence Tomography and Indocyanine Green Angiography.
abstract: OBJECTIVE
  To identify locations of hypofluorescent lesions on late-phase indocyanine green angiography (ICGA) in patients with central serous chorioretinopathy (CSC) using en-face optical coherence tomography (OCT).
  
  
  METHODS
  We retrospectively studied 25 consecutive untreated CSC patients, using swept-source OCT and ICGA. En-face swept-source OCT images were automatically segmented and flattened with Bruch's membrane (BrM). We compared the sizes of hyperreflective areas in the 25 CSC and 25 contralateral eyes on en-face images and hypofluorescent areas on ICGA after 30 min.
  
  
  RESULTS
  All 25 CSC eyes and 13 contralateral eyes showed abnormal hypofluorescent areas on late-phase ICGA and hyperreflective areas on en-face OCT from BrM to the choriocapillaris, and these findings correlated with the abnormal areas (r = 0.9988; p < 0.001).
  
  
  CONCLUSIONS
  In CSC patients, we detected abnormal hypofluorescence on ICGA in the late phase, which corresponded to abnormal hyperreflective areas from BrM to the choriocapillaris level in en-face images.
authors.affiliation: Division of Ophthalmology, Department of Visual Sciences, Nihon University School of Medicine, Tokyo, Japan.
authors.forename: Ari
authors.initials: A
authors.lastname: Shinojima
authors.forename: Kyoko
authors.initials: K
authors.lastname: Fujita
authors.forename: Ryusaburo
authors.initials: R
authors.lastname: Mori
authors.forename: Akiyuki
authors.initials: A
authors.lastname: Kawamura
authors.forename: Mitsuko
authors.initials: M
authors.lastname: Yuzawa
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Yasukawa
mesh_terms: D000328:Adult; D000368:Aged; D056833:Central Serous Chorioretinopathy / Q000175:diagnosis* / Q000209:etiology / Q000503:physiopathology; D002829:Choroid / Q000473:pathology*; D004396:Coloring Agents / Q000494:pharmacology; D005260:Female; D005451:Fluorescein Angiography / Q000379:methods*; D005500:Follow-Up Studies; D005654:Fundus Oculi; D006801:Humans; D007208:Indocyanine Green / Q000494:pharmacology*; D008297:Male; D008875:Middle Aged; D055213:Retinal Pigment Epithelium / Q000473:pathology*; D012189:Retrospective Studies; D041623:Tomography, Optical Coherence / Q000379:methods*; D014792:Visual Acuity
chemical_list: D004396:Coloring Agents; D007208:Indocyanine Green