title: DETERIORARON OF OVARIAN FUNCTION AFTER TOTAL ABDOMINAL HYSTERECTOMY WITH PRESERVARON OF OVARIES.
abstract: OBJECTIVE
  To evaluate ovarian function after total abdominal hysterectomy in premenopausal women.
  
  
  METHODS
  In the present cross-sectional study, we enrolled 52 healthy female subjects having normal menstrual cycle as controls and 37 female patients (age <45 years) who had undergone total abdominal hysterectomy (TAH) with preservation of at least one ovary for the evaluation of ovarian function. Serum antimüllerian hormone (AMH) and follicle-stimulating hormone (FSH) were measured by enzyme-linked immunosorbent assay in both groups. Transvaginal Doppler ultrasonography was done to measure ovarian stromal blood flow indices (resistive index [RI] and pulsatility index [PI]). The means obtained from different sample groups were compared using the nonparametric Mann-Whitney U test, and correlations between two variables were evaluated using the Spearman nonparametric correlation test. A value of P<.05 was considered statistically significant.
  
  
  RESULTS
  Mean postoperative duration of patients who had undergone hysterectomy was 2.5 years. Mean serum AMH level was 7.68 ± 6.70 ng/mL in the cases, significantly lower than the level in controls (10.98 ± 7.83 ng/mL) (P = .016). Serum FSH level in controls was 12.01 ± 6.27 μIU/mL, which was significantly higher in the cases (20.27 ± 12.91 μIU/mL) (P = .001). An inverse correlation between serum AMH and FSH was observed (P = .0006; r = -0.4583). However, the ovary RI and PI values in both groups were similar.
  
  
  CONCLUSIONS
  TAH affects ovarian function, despite normal ovarian blood supply.
  
  
  BACKGROUND
  AMH = antimüllerian hormone FSH = follicle-stimulating hormone RI = resistive index PI = pulsatility index TAH = total abdominal hysterectomy.
authors.forename: Arijit
authors.initials: A
authors.lastname: Singha
authors.forename: Sudipta
authors.initials: S
authors.lastname: Saha
authors.forename: Rana
authors.initials: R
authors.lastname: Bhattacharjee
authors.forename: Samim
authors.initials: S
authors.lastname: Mondal
authors.forename: Subhadip
authors.initials: S
authors.lastname: Choudhuri
authors.forename: Dibakar
authors.initials: D
authors.lastname: Biswas
authors.forename: Souvik Kumar
authors.initials: SK
authors.lastname: Das
authors.forename: Sujoy
authors.initials: S
authors.lastname: Ghosh
authors.forename: Satinath
authors.initials: S
authors.lastname: Mukhopadhyay
authors.forename: Subhankar
authors.initials: S
authors.lastname: Chowdhury
mesh_terms: D000328:Adult; D054304:Anti-Mullerian Hormone / Q000097:blood*; D003430:Cross-Sectional Studies; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood*; D006801:Humans; D007044:Hysterectomy / Q000009:adverse effects*; D010053:Ovary / Q000098:blood supply / Q000000981:diagnostic imaging / Q000503:physiopathology*; D011183:Postoperative Complications / Q000097:blood / Q000000981:diagnostic imaging / Q000503:physiopathology; D018608:Ultrasonography, Doppler
chemical_list: D054304:Anti-Mullerian Hormone; D005640:Follicle Stimulating Hormone