title: A comparative study on the antioxidant effects of hesperidin and ellagic acid against skeletal muscle ischemia/reperfusion injury.
abstract: The antioxidant effects of ellagic acid (EA) and hesperidin (HES) against skeletal muscle ischemia/reperfusion injury (I/R) were performed. Hindlimb ischemia has been induced by tourniquet occlusion for 2 h on left hindlimb. At the end of ischemia, the tourniquate has been removed and initiated reperfusion for 2 h. EA (100 mg/kg) has been applied orally before ischemia/reperfusion in the EA + I/R group. HES (100 mg/kg) has been given orally in the HES + I/R group. The left gastrocnemius muscle has been harvested and stored immediately at -80 °C until assessed for the levels of MDA and antioxidant enzymes activities. MDA level has statistically increased in I/R group (p < 0.05) compared to other groups. The muscle tissue antioxidant enzymes activities were lower than the other groups in the I/R group (p < 0.05). EA and HES treatments significantly reversed the damage level in I/R, also activity of tissue SOD increased in the EA + I/R and HES + I/R groups.
authors.affiliation: a Department of Nutrition and Dietetics , Health School, Ağrı İbrahim Çeçen University , Ağri , Turkey.
authors.forename: Fazile Nur
authors.initials: FN
authors.lastname: Ekinci Akdemir
authors.affiliation: b Department of Chemistry , Atatürk University, Faculty of Sciences , Erzurum , Turkey.|c Department of Zoology , College of Science, King Saud University , Riyadh , Saudi Arabia.
authors.forename: İlhami
authors.initials: İ
authors.lastname: Gülçin
authors.affiliation: d Department of Pharmacology , Faculty of Pharmacy, Ağrı İbrahim Çeçen University , Ağri , Turkey , and.
authors.forename: Berna
authors.initials: B
authors.lastname: Karagöz
authors.affiliation: e Physical Education and Sports, Bartın University , Bartin , Turkey.
authors.forename: Recep
authors.initials: R
authors.lastname: Soslu
authors.affiliation: c Department of Zoology , College of Science, King Saud University , Riyadh , Saudi Arabia.
authors.forename: Saleh H
authors.initials: SH
authors.lastname: Alwasel
mesh_terms: D000284:Administration, Oral; D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology*; D004195:Disease Models, Animal; D004610:Ellagic Acid / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology*; D006569:Hesperidin / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology*; D015227:Lipid Peroxidation / Q000187:drug effects; D018482:Muscle, Skeletal / Q000187:drug effects* / Q000293:injuries / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D015427:Reperfusion Injury / Q000517:prevention & control*
chemical_list: D000975:Antioxidants; D004610:Ellagic Acid; D006569:Hesperidin
keywords: Antioxidant activity; ellagic acid; hesperidin; ischemia/reperfusion injury; skeletal muscle