title: Serum soluble lectin-like oxidized low-density lipoprotein receptor-1 levels in patients with restless legs syndrome.
abstract: OBJECTIVE
  The aim of this study was to assess the predisposition for atherosclerosis in patients with RLS through serum sLOX-1 (serum Lectin-Like Oxidized Low-Density Lipoprotein Receptor-1) measurements.
  
  
  BACKGROUND
  Recent epidemiological studies have suggested an association of RLS with certain chronic conditions such as diabetes mellitus (DM), obesity, hypertension (HT), and hyperlipidemia. LOX-1 is expressed in endothelial cells, macrophages, and in smooth muscle cells under the effect of proatherogenic conditions.
  
  
  METHODS
  This study was a prospective, cross-sectional, case-controlled. We measured the serum sLOX-1 levels in 37 restless legs syndrome patients and 38 controls.
  
  
  RESULTS
  Serum sLOX-1 level was significantly lower in the patient group. The two groups were similar in glucose, HbA1c, creatinine, LDL cholesterol, TG, HDL, total protein, albumin, AST, ALT, GGT, ALP, HGB, HCT, MCV, transferrin saturation rate (TSR), ferritin, CRP, TSH, FT4, FT3, B12, and folic acid levels. Also the two groups were similar with respect to age at menarche, number of previous births, number of abortions and/or curettage, total duration of breastfeeding, percentage of patients in menopause, and age at menopause.
  
  
  CONCLUSIONS
  Our results may suggest a lower atherosclerotic risk among RLS patients as compared to the general population (Tab. 3, Ref. 33).
authors.forename: G
authors.initials: G
authors.lastname: Halac
authors.forename: E
authors.initials: E
authors.lastname: Kilic
authors.forename: M A
authors.initials: MA
authors.lastname: Cikrikcioglu
authors.forename: K
authors.initials: K
authors.lastname: Celik
authors.forename: A
authors.initials: A
authors.lastname: Toprak-Erek
authors.forename: S
authors.initials: S
authors.lastname: Keskin
authors.forename: I
authors.initials: I
authors.lastname: Gultepe
authors.forename: R S
authors.initials: RS
authors.lastname: Celik
authors.forename: N
authors.initials: N
authors.lastname: Ozaras
authors.forename: A
authors.initials: A
authors.lastname: Yildiz
authors.forename: S
authors.initials: S
authors.lastname: Aydin
authors.forename: O
authors.initials: O
authors.lastname: Akan
authors.forename: C
authors.initials: C
authors.lastname: Karatoprak
authors.forename: Y
authors.initials: Y
authors.lastname: Sekin
authors.forename: T
authors.initials: T
authors.lastname: Asil
mesh_terms: D000328:Adult; D000368:Aged; D050197:Atherosclerosis / Q000097:blood; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008875:Middle Aged; D011446:Prospective Studies; D012148:Restless Legs Syndrome / Q000097:blood*; D051127:Scavenger Receptors, Class E / Q000097:blood*
chemical_list: C495137:OLR1 protein, human; D051127:Scavenger Receptors, Class E
keywords: atherosclerosis; restless legs syndrome; sLOX-1.