title: Differential somatostatin and CXCR4 chemokine receptor expression in MALT-type lymphoma of gastric and extragastric origin.
abstract: OBJECTIVE
  Whereas the different somatostatin receptor (SSTR) subtypes and the chemokine receptor CXCR4 are known to be expressed in a wide variety of human malignancies, comprehensive data are still lacking for MALT-type lymphomas.
  
  
  METHODS
  Overall, 55 cases of MALT-type lymphoma of both gastric and extragastric origin were evaluated for the SSTR subtype and CXCR4 expression by means of immunohistochemistry using novel monoclonal rabbit antibodies. The stainings were rated by means of the immunoreactive score and correlated with clinical data.
  
  
  RESULTS
  While the CXCR4 was detected in 92 % of the cases investigated, the SSTR subtypes were much less frequently present. The SSTR5 was expressed in about 50 % of the cases, followed by the SSTR3, the SSTR2A, the SSTR4 and the SSTR1, which were present in 35, 27, 18 or 2 %, respectively, of the tumors only. Gastric lymphomas displayed a significantly higher SSTR3, SSTR4 and SSTR5 expression than extragastric tumors. A correlation between CXCR4 and Ki-67 expression was seen in gastric lymphomas, whereas primarily in extragastric tumors SSTR5 negativity was associated with poor patient outcome.
  
  
  CONCLUSIONS
  The CXCR4 may serve as a promising target for diagnostics and therapy of MALT-type lymphomas, while the SSTRs appear not suitable in this respect.
authors.affiliation: Institute of Pharmacology and Toxicology, Jena University Hospital, Friedrich Schiller University Jena, Drackendorfer Str. 1, 07747, Jena, Germany.
authors.forename: Susann
authors.initials: S
authors.lastname: Stollberg
authors.affiliation: Department of General and Visceral Surgery, Zentralklinik Bad Berka, Bad Berka, Germany.
authors.forename: Daniel
authors.initials: D
authors.lastname: Kämmerer
authors.affiliation: Institute of Pharmacology and Toxicology, Jena University Hospital, Friedrich Schiller University Jena, Drackendorfer Str. 1, 07747, Jena, Germany.
authors.forename: Elisa
authors.initials: E
authors.lastname: Neubauer
authors.affiliation: Institute of Pharmacology and Toxicology, Jena University Hospital, Friedrich Schiller University Jena, Drackendorfer Str. 1, 07747, Jena, Germany.
authors.forename: Stefan
authors.initials: S
authors.lastname: Schulz
authors.affiliation: Clinical Institute for Pathology, University of Vienna, Vienna, Austria.
authors.forename: Ingrid
authors.initials: I
authors.lastname: Simonitsch-Klupp
authors.affiliation: Department of Internal Medicine I, University of Vienna, Vienna, Austria.
authors.forename: Barbara
authors.initials: B
authors.lastname: Kiesewetter
authors.affiliation: Department of Internal Medicine I, University of Vienna, Vienna, Austria.
authors.forename: Markus
authors.initials: M
authors.lastname: Raderer
authors.affiliation: Institute of Pharmacology and Toxicology, Jena University Hospital, Friedrich Schiller University Jena, Drackendorfer Str. 1, 07747, Jena, Germany. Amelie.Lupp@med.uni-jena.de.
authors.forename: Amelie
authors.initials: A
authors.lastname: Lupp
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000595:Amino Acid Sequence; D001327:Autoimmune Diseases / Q000378:metabolism; D005260:Female; D016481:Helicobacter Infections / Q000378:metabolism; D016480:Helicobacter pylori / Q000302:isolation & purification; D006801:Humans; D018442:Lymphoma, B-Cell, Marginal Zone / Q000276:immunology / Q000378:metabolism* / Q000382:microbiology; D008297:Male; D008875:Middle Aged; D019718:Receptors, CXCR4 / Q000096:biosynthesis*; D017481:Receptors, Somatostatin / Q000096:biosynthesis; D013004:Somatostatin / Q000096:biosynthesis*; D013274:Stomach Neoplasms / Q000276:immunology / Q000378:metabolism* / Q000382:microbiology
chemical_list: C527276:CXCR4 protein, human; D019718:Receptors, CXCR4; D017481:Receptors, Somatostatin; D013004:Somatostatin
keywords: CXCR4; Chemokine receptor; Immunohistochemistry; MALT lymphoma; Somatostatin receptors