title: Assessment of variation in immunosuppressive pathway genes reveals TGFBR2 to be associated with risk of clear cell ovarian cancer.
abstract: Regulatory T (Treg) cells, a subset of CD4+ T lymphocytes, are mediators of immunosuppression in cancer, and, thus, variants in genes encoding Treg cell immune molecules could be associated with ovarian cancer.
  
  
  
  In a population of 15,596 epithelial ovarian cancer (EOC) cases and 23,236 controls, we measured genetic associations of 1,351 SNPs in Treg cell pathway genes with odds of ovarian cancer and tested pathway and gene-level associations, overall and by histotype, for the 25 genes, using the admixture likelihood (AML) method. The most significant single SNP associations were tested for correlation with expression levels in 44 ovarian cancer patients.
  
  
  
  The most significant global associations for all genes in the pathway were seen in endometrioid ( p = 0.082) and clear cell ( p = 0.083), with the most significant gene level association seen with TGFBR2 ( p = 0.001) and clear cell EOC. Gene associations with histotypes at p < 0.05 included: IL12 ( p = 0.005 and p = 0.008, serous and high-grade serous, respectively), IL8RA ( p = 0.035, endometrioid and mucinous), LGALS1 ( p = 0.03, mucinous), STAT5B ( p = 0.022, clear cell), TGFBR1 ( p = 0.021 endometrioid) and TGFBR2 ( p = 0.017 and p = 0.025, endometrioid and mucinous, respectively).
  
  
  
  Common inherited gene variation in Treg cell pathways shows some evidence of germline genetic contribution to odds of EOC that varies by histologic subtype and may be associated with mRNA expression of immune-complex receptor in EOC patients.
authors.affiliation: Department of Cancer Epidemiology, Moffitt Cancer Center, Tampa, Florida, USA.
authors.forename: Shalaka S
authors.initials: SS
authors.lastname: Hampras
authors.affiliation: College of Pharmacy, The Ohio State University, Columbus, Ohio, USA.|Department of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, Columbus, Ohio, USA.
authors.forename: Lara E
authors.initials: LE
authors.lastname: Sucheston-Campbell
authors.affiliation: Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, New York, USA.
authors.forename: Rikki
authors.initials: R
authors.lastname: Cannioto
authors.affiliation: German Cancer Research Center (DKFZ), Division of Cancer Epidemiology, Heidelberg, Germany.
authors.forename: Jenny
authors.initials: J
authors.lastname: Chang-Claude
authors.affiliation: Department of Epidemiology and Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.|Women's Cancer Research Program, Magee-Women's Research Institute and University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania, USA.
authors.forename: Francesmary
authors.initials: F
authors.lastname: Modugno
authors.affiliation: Gynaecology Research Unit, Hannover Medical School, Hannover, Germany.
authors.forename: Thilo
authors.initials: T
authors.lastname: Dörk
authors.affiliation: Clinics of Obstetrics and Gynaecology, Hannover Medical School, Hannover, Germany.
authors.forename: Peter
authors.initials: P
authors.lastname: Hillemanns
authors.affiliation: Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, New York, USA.
authors.forename: Leah
authors.initials: L
authors.lastname: Preus
authors.affiliation: Department of Immunology, Mayo Clinic, Rochester, Minnesota, USA.
authors.forename: Keith L
authors.initials: KL
authors.lastname: Knutson
authors.affiliation: Department of Flow & Image Cytometry, Roswell Park Cancer Institute, Buffalo, New York, USA.
authors.forename: Paul K
authors.initials: PK
authors.lastname: Wallace
authors.affiliation: Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, New York, USA.
authors.forename: Chi-Chen
authors.initials: CC
authors.lastname: Hong
authors.affiliation: Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, New York, USA.
authors.forename: Grace
authors.initials: G
authors.lastname: Friel
authors.affiliation: Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, New York, USA.
authors.forename: Warren
authors.initials: W
authors.lastname: Davis
authors.affiliation: Center for Personalized Medicine, Roswell Park Cancer Institute, Buffalo, New York, USA.
authors.forename: Mary
authors.initials: M
authors.lastname: Nesline
authors.affiliation: Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, California, USA.
authors.forename: Celeste L
authors.initials: CL
authors.lastname: Pearce
authors.affiliation: Alberta Health Services-Cancer Care, Department of Population Health Research, Calgary, Alberta, Canada.
authors.forename: Linda E
authors.initials: LE
authors.lastname: Kelemen
authors.affiliation: Cancer Prevention and Control, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA.
authors.forename: Marc T
authors.initials: MT
authors.lastname: Goodman
authors.affiliation: Cancer Prevention and Control, Rutgers Cancer Institute of New Jersey, New Brunswick, New Jersey, USA.
authors.forename: Elisa V
authors.initials: EV
authors.lastname: Bandera
authors.affiliation: Obstetrics and Gynecology Center, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.
authors.forename: Kathryn L
authors.initials: KL
authors.lastname: Terry
authors.affiliation: Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
authors.forename: Nils
authors.initials: N
authors.lastname: Schoof
authors.affiliation: Department of Biostatistics & Bioinformatics, Roswell Park Cancer Institute, Buffalo, New York, USA.
authors.forename: Kevin H
authors.initials: KH
authors.lastname: Eng
authors.affiliation: Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, New York, USA.
authors.forename: Alyssa
authors.initials: A
authors.lastname: Clay
authors.affiliation: Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, New York, USA.
authors.forename: Prashant K
authors.initials: PK
authors.lastname: Singh
authors.affiliation: Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, New York, USA.
authors.forename: Janine M
authors.initials: JM
authors.lastname: Joseph
authors.affiliation: Department for Health Evidence, Radboud University Medical Centre, Nijmegen, The Netherlands.
authors.forename: Katja K H
authors.initials: KK
authors.lastname: Aben
authors.affiliation: Department of Epidemiology and School of Medicine, University of California Irvine, Irvine, California, USA.
authors.forename: Hoda
authors.initials: H
authors.lastname: Anton-Culver
authors.affiliation: Byelorussian Institute for Oncology and Medical Radiology Aleksandrov N.N., Minsk, Belarus.
authors.forename: Natalia
authors.initials: N
authors.lastname: Antonenkova
authors.affiliation: Department of Oncology, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK.
authors.forename: Helen
authors.initials: H
authors.lastname: Baker
authors.affiliation: Department of Obstetrics & Gynecology and Knight Cancer Institute, Oregon Health & Science University, Portland, Oregon, USA.
authors.forename: Yukie
authors.initials: Y
authors.lastname: Bean
authors.affiliation: Department of Gynecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nuremberg, Erlangen, Germany.
authors.forename: Matthias W
authors.initials: MW
authors.lastname: Beckmann
authors.affiliation: Gynecology Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
authors.forename: Maria
authors.initials: M
authors.lastname: Bisogna
authors.affiliation: Department of Gynecology and Obstetrics, Haukeland University Hospital, Bergen, Norway.
authors.forename: Line
authors.initials: L
authors.lastname: Bjorge
authors.affiliation: Gynaecology Research Unit, Hannover Medical School, Hannover, Germany.
authors.forename: Natalia
authors.initials: N
authors.lastname: Bogdanova
authors.affiliation: Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA.
authors.forename: Louise A
authors.initials: LA
authors.lastname: Brinton
authors.affiliation: Canada's Michael Smith Genome Sciences Centre, BC Cancer Agency, Vancouver, British Columbia, Canada.
authors.forename: Angela
authors.initials: A
authors.lastname: Brooks-Wilson
authors.affiliation: Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Australia.
authors.forename: Fiona
authors.initials: F
authors.lastname: Bruinsma
authors.affiliation: Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland.
authors.forename: Ralf
authors.initials: R
authors.lastname: Butzow
authors.affiliation: Cancer Genetics Laboratory, Research Division, Peter MacCallum Cancer Centre, St Andrews Place, East Melbourne, Australia.
authors.forename: Ian G
authors.initials: IG
authors.lastname: Campbell
authors.affiliation: Cancer Research UK Clinical Trials Unit, The Beatson West of Scotland Cancer Centre, University of Glasgow, Glasgow, UK.
authors.forename: Karen
authors.initials: K
authors.lastname: Carty
authors.affiliation: Division of Epidemiology and Biostatistics, Department of Internal Medicine, University of New Mexico, Albuquerque, New Mexico, USA.
authors.forename: Linda S
authors.initials: LS
authors.lastname: Cook
authors.affiliation: Obstetrics and Gynecology Center, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.
authors.forename: Daniel W
authors.initials: DW
authors.lastname: Cramer
authors.affiliation: International Hereditary Cancer Center, Department of Genetics and Pathology, Clinic of Opthalmology, Pomeranian Medical University, Szczecin, Poland.
authors.forename: Cezary
authors.initials: C
authors.lastname: Cybulski
authors.affiliation: Department of Pathology and Labolatory Diagnostic, The Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Warsaw, Poland.
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Dansonka-Mieszkowska
authors.affiliation: Department of Oncology, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK.
authors.forename: Joe
authors.initials: J
authors.lastname: Dennis
authors.affiliation: Division of Gynecological Oncology, Department of Oncology, University Hospitals Leuven, Belgium.
authors.forename: Evelyn
authors.initials: E
authors.lastname: Despierre
authors.affiliation: Department of Oncology, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK.
authors.forename: Ed
authors.initials: E
authors.lastname: Dicks
authors.affiliation: Department of Community and Family Medicine, Section of Biostatistics & Epidemiology, The Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, USA.
authors.forename: Jennifer A
authors.initials: JA
authors.lastname: Doherty
authors.affiliation: Department of Gynecology and Gynecologic Oncology, Kliniken Essen-Mitte/ Evang. Huyssens-Stiftung/ Knappschaft GmbH, Essen, Germany.
authors.forename: Andreas
authors.initials: A
authors.lastname: du Bois
authors.affiliation: Department of Gynecology, Jena University Hospital - Friedrich Schiller University, Jena, Germany.
authors.forename: Matthias
authors.initials: M
authors.lastname: Dürst
authors.affiliation: Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
authors.forename: Doug
authors.initials: D
authors.lastname: Easton
authors.affiliation: Wessex Clinical Genetics Service, Princess Anne Hospital, Southampton, UK.
authors.forename: Diana
authors.initials: D
authors.lastname: Eccles
authors.affiliation: Department of Obstetrics, Gynecology & Reproductive Sciences and Ovarian Cancer Center of Excellence, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
authors.forename: Robert P
authors.initials: RP
authors.lastname: Edwards
authors.affiliation: Institute of Human Genetics, University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nuremberg, Erlangen, Germany.
authors.forename: Arif B
authors.initials: AB
authors.lastname: Ekici
authors.affiliation: Department of Medicine, Division of Hematology and Oncology, University of California at Los Angeles, Los Angeles, California, USA.
authors.forename: Peter A
authors.initials: PA
authors.lastname: Fasching
authors.affiliation: Department of Biostatistics, University of Kansas Medical Center, Kansas City, Kansas, USA,.
authors.forename: Brooke L
authors.initials: BL
authors.lastname: Fridley
authors.affiliation: Shanghai Cancer Institute, Shanghai, China.
authors.forename: Yu-Tang
authors.initials: YT
authors.lastname: Gao
authors.affiliation: Institute for Women's Health, Population Health Sciences, University College - London, London, United Kingdom.
authors.forename: Aleksandra
authors.initials: A
authors.lastname: Gentry-Maharaj
authors.affiliation: Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Australia.|Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Victoria, Australia.
authors.forename: Graham G
authors.initials: GG
authors.lastname: Giles
authors.affiliation: Cancer Research UK Clinical Trials Unit, The Beatson West of Scotland Cancer Centre, University of Glasgow, Glasgow, UK.
authors.forename: Rosalind
authors.initials: R
authors.lastname: Glasspool
authors.affiliation: International Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland.
authors.forename: Jacek
authors.initials: J
authors.lastname: Gronwald
authors.affiliation: Department of Oncology, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK.
authors.forename: Patricia
authors.initials: P
authors.lastname: Harrington
authors.affiliation: Department of Gynecology and Gynecologic Oncology, Kliniken Essen-Mitte/ Evang. Huyssens-Stiftung/ Knappschaft GmbH, Essen, Germany.
authors.forename: Philipp
authors.initials: P
authors.lastname: Harter
authors.affiliation: Cancer Research Initiatives Foundation, Sime Darby Medical Center, Subang Jaya, Malaysia.
authors.forename: Hanis Nazihah
authors.initials: HN
authors.lastname: Hasmad
authors.affiliation: Department of Gynecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nuremberg, Erlangen, Germany.
authors.forename: Alexander
authors.initials: A
authors.lastname: Hein
authors.affiliation: Department of Gynecology and Gynecologic Oncology, Kliniken Essen-Mitte/ Evang. Huyssens-Stiftung/ Knappschaft GmbH, Essen, Germany.
authors.forename: Florian
authors.initials: F
authors.lastname: Heitz
authors.affiliation: Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
authors.forename: Michelle A T
authors.initials: MA
authors.lastname: Hildebrandt
authors.affiliation: Department of Gynaecology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
authors.forename: Claus
authors.initials: C
authors.lastname: Hogdall
authors.affiliation: Institute of Cancer Epidemiology, Danish Cancer Society, Copenhagen, Denmark.
authors.forename: Estrid
authors.initials: E
authors.lastname: Hogdall
authors.affiliation: Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Aichi, Japan.
authors.forename: Satoyo
authors.initials: S
authors.lastname: Hosono
authors.affiliation: Department of Statistical Science, Duke University, Durham, North Carolina, USA.
authors.forename: Edwin S
authors.initials: ES
authors.lastname: Iversen
authors.affiliation: International Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland.
authors.forename: Anna
authors.initials: A
authors.lastname: Jakubowska
authors.affiliation: Department of Virus, Lifestyle and Genes, Danish Cancer Society Research Center, Copenhagen, Denmark.
authors.forename: Allan
authors.initials: A
authors.lastname: Jensen
authors.affiliation: Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA.
authors.forename: Bu-Tian
authors.initials: BT
authors.lastname: Ji
authors.affiliation: Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA.
authors.forename: Beth Y
authors.initials: BY
authors.lastname: Karlan
authors.affiliation: Department of Obstetrics & Gynecology and Knight Cancer Institute, Oregon Health & Science University, Portland, Oregon, USA.
authors.forename: Melissa
authors.initials: M
authors.lastname: Kellar
authors.affiliation: Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
authors.forename: Joseph L
authors.initials: JL
authors.lastname: Kelley
authors.affiliation: Department for Health Evidence, Radboud University Medical Centre, Nijmegen, The Netherlands.
authors.forename: Lambertus A
authors.initials: LA
authors.lastname: Kiemeney
authors.affiliation: Gynaecology Research Unit, Hannover Medical School, Hannover, Germany.
authors.forename: Rüdiger
authors.initials: R
authors.lastname: Klapdor
authors.affiliation: Division of Gynecologic Oncology, Roswell Park Cancer Institute, Buffalo, New York, USA.
authors.forename: Nonna
authors.initials: N
authors.lastname: Kolomeyevskaya
authors.affiliation: Department of Gynecology and Obstetrics, Haukeland University Hospital, Bergen, Norway.
authors.forename: Camilla
authors.initials: C
authors.lastname: Krakstad
authors.affiliation: Department of Gynaecology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.|Department of Virus, Lifestyle and Genes, Danish Cancer Society Research Center, Copenhagen, Denmark.
authors.forename: Susanne K
authors.initials: SK
authors.lastname: Kjaer
authors.affiliation: Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, New York, USA.
authors.forename: Bridget
authors.initials: B
authors.lastname: Kruszka
authors.affiliation: Department of Pathology and Labolatory Diagnostic, The Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Warsaw, Poland.
authors.forename: Jolanta
authors.initials: J
authors.lastname: Kupryjanczyk
authors.affiliation: Vesalius Research Center, VIB, Leuven, Belgium,.|Laboratory for Translational Genetics, Department of Oncology, University of Leuven, Belgium.
authors.forename: Diether
authors.initials: D
authors.lastname: Lambrechts
authors.affiliation: Division of Gynecological Oncology, Department of Oncology, University Hospitals Leuven, Belgium.
authors.forename: Sandrina
authors.initials: S
authors.lastname: Lambrechts
authors.affiliation: Cancer Control Research, BC Cancer Agency, Vancouver, British Columbia, Canada.
authors.forename: Nhu D
authors.initials: ND
authors.lastname: Le
authors.affiliation: Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, California, USA.
authors.forename: Alice W
authors.initials: AW
authors.lastname: Lee
authors.affiliation: Division of Gynecologic Oncology, Roswell Park Cancer Institute, Buffalo, New York, USA.
authors.forename: Shashikant
authors.initials: S
authors.lastname: Lele
authors.affiliation: Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland.
authors.forename: Arto
authors.initials: A
authors.lastname: Leminen
authors.affiliation: Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA.
authors.forename: Jenny
authors.initials: J
authors.lastname: Lester
authors.affiliation: Gynecology Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
authors.forename: Douglas A
authors.initials: DA
authors.lastname: Levine
authors.affiliation: College of Pharmacy and Health Sciences, Texas Southern University, Houston, Texas, USA.
authors.forename: Dong
authors.initials: D
authors.lastname: Liang
authors.affiliation: Department of Cancer Epidemiology and Prevention, M. Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Warsaw, Poland.
authors.forename: Jolanta
authors.initials: J
authors.lastname: Lissowska
authors.affiliation: Department of Biostatistics & Bioinformatics, Roswell Park Cancer Institute, Buffalo, New York, USA.
authors.forename: Song
authors.initials: S
authors.lastname: Liu
authors.affiliation: Department of Cancer Epidemiology and Prevention, M. Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Warsaw, Poland.
authors.forename: Karen
authors.initials: K
authors.lastname: Lu
authors.affiliation: Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Victoria, Australia.
authors.forename: Jan
authors.initials: J
authors.lastname: Lubinski
authors.affiliation: Department of Gynaecology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
authors.forename: Lene
authors.initials: L
authors.lastname: Lundvall
authors.affiliation: Department of Gynaecology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.
authors.forename: Leon F A G
authors.initials: LF
authors.lastname: Massuger
authors.affiliation: Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Aichi, Japan.
authors.forename: Keitaro
authors.initials: K
authors.lastname: Matsuo
authors.affiliation: Department of Health Research and Policy - Epidemiology, Stanford University School of Medicine, Stanford, California, USA.
authors.forename: Valeria
authors.initials: V
authors.lastname: McGuire
authors.affiliation: Prosserman Centre for Health Research, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada.
authors.forename: John R
authors.initials: JR
authors.lastname: McLaughlin
authors.affiliation: Institute of Cancer Sciences, University of Glasgow, Glasgow, UK.
authors.forename: Ian
authors.initials: I
authors.lastname: McNeish
authors.affiliation: Women's Cancer, UCL EGA Institute for Women's Health, London, UK.
authors.forename: Usha
authors.initials: U
authors.lastname: Menon
authors.affiliation: Department of Pathology and Labolatory Diagnostic, The Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Warsaw, Poland.
authors.forename: Joanna
authors.initials: J
authors.lastname: Moes-Sosnowska
authors.affiliation: Women's College Research Institute, Toronto, Ontario, Canada.
authors.forename: Steven A
authors.initials: SA
authors.lastname: Narod
authors.affiliation: Department of Pathology, Rigshospitalet, University of Copenhagen, Denmark.
authors.forename: Lotte
authors.initials: L
authors.lastname: Nedergaard
authors.affiliation: Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland.
authors.forename: Heli
authors.initials: H
authors.lastname: Nevanlinna
authors.affiliation: German Cancer Research Center (DKFZ), Division of Cancer Epidemiology, Heidelberg, Germany.
authors.forename: Stefan
authors.initials: S
authors.lastname: Nickels
authors.affiliation: Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center, New York, New York, USA.
authors.forename: Sara H
authors.initials: SH
authors.lastname: Olson
authors.affiliation: Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center, New York, New York, USA,.
authors.forename: Irene
authors.initials: I
authors.lastname: Orlow
authors.affiliation: Department of Community and Family Medicine, Duke University Medical Center, Durham, North Carolina, USA.
authors.forename: Rachel Palmieri
authors.initials: RP
authors.lastname: Weber
authors.affiliation: Cancer Research UK Clinical Trials Unit, The Beatson West of Scotland Cancer Centre, University of Glasgow, Glasgow, UK.
authors.forename: James
authors.initials: J
authors.lastname: Paul
authors.affiliation: Department of Oncology, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK.
authors.forename: Tanja
authors.initials: T
authors.lastname: Pejovic
authors.affiliation: Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland.
authors.forename: Liisa M
authors.initials: LM
authors.lastname: Pelttari
authors.affiliation: Department of Oncology, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK.
authors.forename: Barbara
authors.initials: B
authors.lastname: Perkins
authors.affiliation: Department of Cancer Epidemiology, Moffitt Cancer Center, Tampa, Florida, USA.
authors.forename: Jenny
authors.initials: J
authors.lastname: Permuth-Wey
authors.affiliation: Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, California, USA.|Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center, New York, New York, USA.
authors.forename: Malcolm C
authors.initials: MC
authors.lastname: Pike
authors.affiliation: Department of Pathology and Labolatory Diagnostic, The Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Warsaw, Poland.
authors.forename: Joanna
authors.initials: J
authors.lastname: Plisiecka-Halasa
authors.affiliation: Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.
authors.forename: Elizabeth M
authors.initials: EM
authors.lastname: Poole
authors.affiliation: Department of Chronic Disease Epidemiology, Yale School of Public Health, New Haven, Connecticut, USA.
authors.forename: Harvey A
authors.initials: HA
authors.lastname: Risch
authors.affiliation: Program in Epidemiology, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.
authors.forename: Mary Anne
authors.initials: MA
authors.lastname: Rossing
authors.affiliation: Department of Health Research and Policy - Epidemiology, Stanford University School of Medicine, Stanford, California, USA.
authors.forename: Joseph H
authors.initials: JH
authors.lastname: Rothstein
authors.affiliation: German Cancer Research Center (DKFZ), Division of Cancer Epidemiology, Heidelberg, Germany.
authors.forename: Anja
authors.initials: A
authors.lastname: Rudolph
authors.affiliation: Department of Gynecology, Jena University Hospital - Friedrich Schiller University, Jena, Germany.
authors.forename: Ingo B
authors.initials: IB
authors.lastname: Runnebaum
authors.affiliation: Department of Pathology and Labolatory Diagnostic, The Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Warsaw, Poland.
authors.forename: Iwona K
authors.initials: IK
authors.lastname: Rzepecka
authors.affiliation: Department of Gynecology and Obstetrics, Haukeland University Hospital, Bergen, Norway.
authors.forename: Helga B
authors.initials: HB
authors.lastname: Salvesen
authors.affiliation: Department of Community and Family Medicine, Duke University Medical Center, Durham, North Carolina, USA.
authors.forename: Eva
authors.initials: E
authors.lastname: Schernhammer
authors.affiliation: Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, New York, USA.
authors.forename: Kristina
authors.initials: K
authors.lastname: Schmitt
authors.affiliation: Institut für Humangenetik Wiesbaden, Wiesbaden, Germany.
authors.forename: Ira
authors.initials: I
authors.lastname: Schwaab
authors.affiliation: Vanderbilt Epidemiology Center, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
authors.forename: Xiao-Ou
authors.initials: XO
authors.lastname: Shu
authors.affiliation: Cancer Epidemiology Program, University of Hawaii Cancer Center, Hawaii, USA.
authors.forename: Yurii B
authors.initials: YB
authors.lastname: Shvetsov
authors.affiliation: Department of Gynaecological Oncology, Glasgow Royal Infirmary, Glasgow, Scotland, UK.
authors.forename: Nadeem
authors.initials: N
authors.lastname: Siddiqui
authors.affiliation: Department of Health Research and Policy - Epidemiology, Stanford University School of Medicine, Stanford, California, USA.
authors.forename: Weiva
authors.initials: W
authors.lastname: Sieh
authors.affiliation: Department of Oncology, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK.
authors.forename: Honglin
authors.initials: H
authors.lastname: Song
authors.affiliation: Department of Pathology, The University of Melbourne, Melbourne, Australia.
authors.forename: Melissa C
authors.initials: MC
authors.lastname: Southey
authors.affiliation: Department of Gynecology and Obstetrics, Haukeland University Hospital, Bergen, Norway.
authors.forename: Ingvild L
authors.initials: IL
authors.lastname: Tangen
authors.affiliation: Cancer Research Initiatives Foundation, Sime Darby Medical Center, Subang Jaya, Malaysia,.
authors.forename: Soo-Hwang
authors.initials: SH
authors.lastname: Teo
authors.affiliation: Cancer Prevention and Control, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA.
authors.forename: Pamela J
authors.initials: PJ
authors.lastname: Thompson
authors.affiliation: Department of Obstetrics, Gynecology and Oncology, Warsaw Medical University and Brodnowski Hospital, Warsaw, Poland.
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Timorek
authors.affiliation: Department of Cancer Epidemiology, Moffitt Cancer Center, Tampa, Florida, USA.
authors.forename: Ya-Yu
authors.initials: YY
authors.lastname: Tsai
authors.affiliation: Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.
authors.forename: Shelley S
authors.initials: SS
authors.lastname: Tworoger
authors.affiliation: Department of Oncology, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK.
authors.forename: Jonathan
authors.initials: J
authors.lastname: Tyrer
authors.affiliation: Department of Gynaecology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.
authors.forename: Anna M
authors.initials: AM
authors.lastname: van Altena
authors.affiliation: Division of Gynecological Oncology, Department of Oncology, University Hospitals Leuven, Belgium.
authors.forename: Ignace
authors.initials: I
authors.lastname: Vergote
authors.affiliation: Department of Health Science Research, Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, Minnesota, USA.
authors.forename: Robert A
authors.initials: RA
authors.lastname: Vierkant
authors.affiliation: Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA.
authors.forename: Christine
authors.initials: C
authors.lastname: Walsh
authors.affiliation: German Cancer Research Center (DKFZ), Division of Cancer Epidemiology, Heidelberg, Germany.
authors.forename: Shan
authors.initials: S
authors.lastname: Wang-Gohrke
authors.affiliation: Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA.
authors.forename: Nicolas
authors.initials: N
authors.lastname: Wentzensen
authors.affiliation: Department of Health Research and Policy - Epidemiology, Stanford University School of Medicine, Stanford, California, USA.
authors.forename: Alice S
authors.initials: AS
authors.lastname: Whittemore
authors.affiliation: Program in Epidemiology, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.
authors.forename: Kristine G
authors.initials: KG
authors.lastname: Wicklund
authors.affiliation: Cancer Epidemiology Program, University of Hawaii Cancer Center, Hawaii, USA.
authors.forename: Lynne R
authors.initials: LR
authors.lastname: Wilkens
authors.affiliation: Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, California, USA.
authors.forename: Anna H
authors.initials: AH
authors.lastname: Wu
authors.affiliation: Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
authors.forename: Xifeng
authors.initials: X
authors.lastname: Wu
authors.affiliation: Department of Obstetrics and Gynaecology, Affiliated with UM Cancer Research Institute, Faculty of Medicine, University of Malaya, Malaysia.
authors.forename: Yin-Ling
authors.initials: YL
authors.lastname: Woo
authors.affiliation: Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA.
authors.forename: Hannah
authors.initials: H
authors.lastname: Yang
authors.affiliation: Vanderbilt Epidemiology Center, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
authors.forename: Wei
authors.initials: W
authors.lastname: Zheng
authors.affiliation: Department of Epidemiology and School of Medicine, University of California Irvine, Irvine, California, USA.
authors.forename: Argyrios
authors.initials: A
authors.lastname: Ziogas
authors.affiliation: Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, California, USA.
authors.forename: Simon A
authors.initials: SA
authors.lastname: Gayther
authors.affiliation: Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, California, USA.
authors.forename: Susan J
authors.initials: SJ
authors.lastname: Ramus
authors.affiliation: Department of Cancer Epidemiology, Moffitt Cancer Center, Tampa, Florida, USA.
authors.forename: Thomas A
authors.initials: TA
authors.lastname: Sellers
authors.affiliation: Department of Community and Family Medicine, Duke University Medical Center, Durham, North Carolina, USA.
authors.forename: Joellen M
authors.initials: JM
authors.lastname: Schildkraut
authors.affiliation: Department of Cancer Epidemiology, Moffitt Cancer Center, Tampa, Florida, USA.
authors.forename: Catherine M
authors.initials: CM
authors.lastname: Phelan
authors.affiliation: Department of Obstetrics and Gynecology, Duke University Medical Center, Durham, North Carolina, USA.
authors.forename: Andrew
authors.initials: A
authors.lastname: Berchuck
authors.affiliation: Cancer Division, QIMR Berghofer Medical Research Institute, Brisbane, Australia.|On behalf of the Australian Ovarian Cancer Study Group.
authors.forename: Georgia
authors.initials: G
authors.lastname: Chenevix-Trench
authors.affiliation: Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA.
authors.forename: Julie M
authors.initials: JM
authors.lastname: Cunningham
authors.affiliation: Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
authors.forename: Paul P
authors.initials: PP
authors.lastname: Pharoah
authors.affiliation: School of Public Health, The University of Texas, Houston, Texas, USA.
authors.forename: Roberta B
authors.initials: RB
authors.lastname: Ness
authors.affiliation: Division of Gynecologic Oncology, Roswell Park Cancer Institute, Buffalo, New York, USA.
authors.forename: Kunle
authors.initials: K
authors.lastname: Odunsi
authors.affiliation: Department of Health Science Research, Division of Epidemiology, Mayo Clinic, Rochester, Minnesota, USA.
authors.forename: Ellen L
authors.initials: EL
authors.lastname: Goode
authors.affiliation: Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, New York, USA.
authors.forename: Kirsten B
authors.initials: KB
authors.lastname: Moysich
mesh_terms: D018262:Adenocarcinoma, Clear Cell / Q000235:genetics* / Q000276:immunology; D000328:Adult; D000368:Aged; D000077216:Carcinoma, Ovarian Epithelial; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D006801:Humans; D008875:Middle Aged; D009375:Neoplasms, Glandular and Epithelial / Q000235:genetics* / Q000276:immunology; D010051:Ovarian Neoplasms / Q000235:genetics* / Q000276:immunology; D020641:Polymorphism, Single Nucleotide; D017346:Protein Serine-Threonine Kinases / Q000235:genetics*; D000077294:Receptor, Transforming Growth Factor-beta Type II; D018125:Receptors, Transforming Growth Factor beta / Q000235:genetics*; D012307:Risk Factors; D050378:T-Lymphocytes, Regulatory / Q000276:immunology / Q000378:metabolism
chemical_list: D018125:Receptors, Transforming Growth Factor beta; D017346:Protein Serine-Threonine Kinases; D000077294:Receptor, Transforming Growth Factor-beta Type II
keywords: TGFBR2	; biomarkers; genetic variation; immunosuppression; ovarian cancer