title: [DIAGNOSIS OF MINOR FORMS AND OCCULT ACTIVITY OF TUBERCULOSIS IN CHILDREN AND ADOLESCENTS BY NITROBLUE TETRASOLIUM TEST].
abstract: Examination of 270 children and 74 adolescents by the currently available studies using the NBT test with specific antigens (BCG and tuberculin) could first diagnose the circumscribed forms of pulmonary and extrapulmonary tuberculosis in 6.7%. There was evidence for the persistent activity of inflammation in the presence of calcifications in 39 (11.3%) of the pretreated tuberculosis patients. The diagnosis in all the patients was associated with a positive NBT test. The latter could define indications for chemoprophylaxis of tuberculosis in 109 (31.7%) subjects, rule out a need for drugs in this period in 109 (31.7%) patients, and establish no need for phthisiatricians to follow up 135 (39.2) patients. NBT test was shown to be a tool to confirm or exclude the activity of tuberculosis infection in children and adolescents.
mesh_terms: D000293:Adolescent; D018890:Chemoprevention / Q000379:methods; D002648:Child; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007202:Indicators and Reagents / Q000494:pharmacology; D008297:Male; D009580:Nitroblue Tetrazolium / Q000494:pharmacology*; D018579:Patient Selection; D015203:Reproducibility of Results; D014374:Tuberculin Test / Q000379:methods*; D014376:Tuberculosis / Q000175:diagnosis* / Q000517:prevention & control / Q000628:therapy
chemical_list: D007202:Indicators and Reagents; D009580:Nitroblue Tetrazolium