title: The Role of RhoJ in Endothelial Cell Biology and Tumor Pathology.
abstract: Background. RhoJ, an endothelially expressed member of Cdc42 (cell division cycle 42) subfamily of Rho GTPase, plays an important role in endocytic pathway, adipocyte differentiation, endothelial motility, tube formation, and focal adhesion. RhoJ is a selective and effective therapeutic target in tumor tissues or retinopathy. Methods. A systematic review was related to "small Rho GTPase" or "RhoJ" with "endothelial motility, tube formation and focal adhesion" and "tumor therapy". This led to many cross-references involving RhoJ and these data have been incorporated into the following study. Results. We have grouped the role of RhoJ according to three main effects: RhoJ regulates endocytic pathway and adipocyte differentiation in early studies, and RhoJ shows an important role in endothelial cell biology; furthermore, RhoJ blockade serves as a target in tumor vasculature and enhances the effects of anticancer drug. Conclusions. More research is necessary to understand the role of RhoJ in many aspects, on the basis of current knowledge of the role of RhoJ blockade in tumor vessels, there are opportunities for the therapy of tumor, and RhoJ is expressed outside tumour vasculature and is involved in wound healing. Taking advantage of the opportunities could result in a development in tumor therapy.
authors.affiliation: School of Medicine, University of Electronic Science and Technology of China, Chengdu 610054, China.
authors.forename: Ting-Ting
authors.initials: TT
authors.lastname: Shi
authors.affiliation: School of Medicine, University of Electronic Science and Technology of China, Chengdu 610054, China; Department of Pharmacy, Hospital of the University of Electronic Science and Technology of China and Sichuan Provincial People's Hospital, Chengdu 610072, China; Sichuan Translational Medicine Hospital, Chinese Academy of Sciences, Chengdu 610072, China.
authors.forename: Gang
authors.initials: G
authors.lastname: Li
authors.affiliation: School of Medicine, University of Electronic Science and Technology of China, Chengdu 610054, China; Department of Pharmacy, Hospital of the University of Electronic Science and Technology of China and Sichuan Provincial People's Hospital, Chengdu 610072, China; Sichuan Translational Medicine Hospital, Chinese Academy of Sciences, Chengdu 610072, China.
authors.forename: Hong-Tao
authors.identifier: 0000-0003-1725-7550
authors.initials: HT
authors.lastname: Xiao
mesh_terms: D000818:Animals; D004705:Endocytosis / Q000502:physiology; D042783:Endothelial Cells / Q000378:metabolism* / Q000473:pathology*; D022001:Focal Adhesions / Q000378:metabolism / Q000473:pathology; D006801:Humans; D009369:Neoplasms / Q000378:metabolism* / Q000473:pathology*; D015398:Signal Transduction / Q000502:physiology; D020741:rho GTP-Binding Proteins / Q000378:metabolism*
chemical_list: D020741:rho GTP-Binding Proteins