title: Factors that promote macrophage homing to adipose tissue in metabolic syndrome.
abstract: Metabolic syndrome (MetS), a common cardio-metabolic cluster, predisposes to both increased cardiovascular disease and diabetes. Both adipose tissue and monocyte/macrophages contribute to the increased inflammation in MetS. However there are sparse data on factors that determine macrophage recruitment into adipose tissue (AT). In this preliminary report in patients with MetS, without the confounding of diabetes and cardiovascular diseases, we show that plasma resistin, soluble CD14 and monocyte p38 MAP kinase activity correlate significantly with AT macrophage density and hence could be important biomediators of macrophage homing to AT in MetS. However larger studies are required to confirm these novel findings and elucidate other important factors.
authors.affiliation: Laboratory of Atherosclerosis and Metabolic Research, Department of Pathology and Internal Medicine, University of California Davis Medical Center, Sacramento, CA, USA; Veterans Affairs Medical Center, Mather, CA, USA. Electronic address: kjialal@gmail.com.
authors.forename: Ishwarlal
authors.initials: I
authors.lastname: Jialal
authors.affiliation: Division of Biostatistics, Department of Clinical Sciences, University of Texas Southwestern Medical Center, Dallas, TX, USA.
authors.forename: Beverley
authors.initials: B
authors.lastname: Adams-Huet
authors.affiliation: Department of Pathology & Immunology, Baylor College of Medicine, Houston, TX, USA.
authors.forename: Sridevi
authors.initials: S
authors.lastname: Devaraj
mesh_terms: D000273:Adipose Tissue / Q000503:physiopathology*; D000328:Adult; D000368:Aged; D002318:Cardiovascular Diseases; D016022:Case-Control Studies; D002465:Cell Movement; D003920:Diabetes Mellitus; D005260:Female; D006801:Humans; D007249:Inflammation; D018950:Lipopolysaccharide Receptors / Q000097:blood; D008264:Macrophages / Q000166:cytology*; D008297:Male; D024821:Metabolic Syndrome / Q000503:physiopathology*; D008875:Middle Aged; D009000:Monocytes / Q000201:enzymology; D052243:Resistin / Q000097:blood; D048051:p38 Mitogen-Activated Protein Kinases / Q000378:metabolism
chemical_list: D018950:Lipopolysaccharide Receptors; C499624:RETN protein, human; D052243:Resistin; D048051:p38 Mitogen-Activated Protein Kinases
keywords: Adipose tissue; Inflammation; MONOCYTES; Metabolic syndrome; Resistin; Soluble CD14