title: Acute Aortic Dissection Presenting as Bilateral Lower Extremity Paralysis: A Case Report.
abstract: BACKGROUND
  First described by Morgagni in 1761, aortic dissection (AD) is an acute life-threatening and time-sensitive disease process with an increasing mortality approaching 1% for every 1-hour delay in diagnosis within the first 48 hours. Despite continued surgical advancement, overall in-hospital mortality remains significant (27.4%).
  
  
  METHODS
  A 56-year-old woman presented to an outlying emergency department with a complaint of isolated lumbar pain associated with right lower extremity paresthesia and paralysis that progressed to the left. Her medical history and a review of symptoms were significant for chronic obstructive pulmonary disease and tobacco abuse. The initial evaluation in the emergency department included laboratory values and a computed tomography scan of the lumbar spine that revealed minimal disease. After transfer to our tertiary care center for an emergent magnetic resonance imaging scan of the lumbar spine, her vital signs were as follows: blood pressure, 176/84 mm Hg; heart rate, 76 beats/min; respiratory rate, 24 breaths/min; afebrile; and oxygen saturation 98% on room air. A repeat examination revealed cold extremities with mottling, bilateral symmetric lower extremity flaccid paralysis, and a loss of pulses and reflexes. She was insensate below the T10 dermatome. Her upper extremities and cranial nerves were normal. She underwent computed tomography angiography, revealing an extensive Stanford type A AD with interim thrombus formation. After successful endograft stenting, she died 24 hours later. WHY SHOULD AN EMERGENCY PHYSICIAN BE AWARE OF THIS?: Comprising <2% of all ADs, the pathophysiology of paraplegia as the initial presentation of AD is caused by compression of the anterior spinal artery, resulting in ischemia of the spinal cord. Acute AD is a life-threatening medical emergency that requires a high clinical level of suspicion because of its often variable presentation and high incidence of mortality.
authors.affiliation: Sparrow Hospital, Lansing, Michigan.
authors.forename: Kate E
authors.initials: KE
authors.lastname: Hughes
authors.affiliation: Sparrow Hospital, Lansing, Michigan.
authors.forename: Colin
authors.initials: C
authors.lastname: Seguin
authors.affiliation: Sparrow Hospital, Lansing, Michigan.
authors.forename: Brent
authors.initials: B
authors.lastname: Felton
authors.affiliation: Michigan State University, East Lansing, Michigan.
authors.forename: Mary J
authors.initials: MJ
authors.lastname: Hughes
authors.affiliation: Sparrow Hospital, Lansing, Michigan.
authors.forename: David
authors.initials: D
authors.lastname: Castle
mesh_terms: D000208:Acute Disease; D000784:Aortic Dissection / Q000150:complications / Q000000981:diagnostic imaging* / Q000601:surgery; D001014:Aortic Aneurysm / Q000150:complications / Q000000981:diagnostic imaging* / Q000601:surgery; D000072226:Computed Tomography Angiography; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D017116:Low Back Pain / Q000209:etiology; D008875:Middle Aged; D010264:Paraplegia / Q000209:etiology; D010292:Paresthesia / Q000209:etiology
keywords: aortic dissection; back pain; lower extremity paralysis; paresthesias