title: A polymethoxyflavone mixture, extracted from orange peels, suppresses the UVB-induced expression of MMP-1.
abstract: Ultraviolet (UV) B is the main cause of skin photoageing, which has characteristic features such as deep wrinkles. UVB increases the expression of matrix metalloproteinases (MMPs) in the skin and can cause wrinkles by disrupting components of the extracellular matrix, such as collagen fibres. We now report that a polymethoxyflavone (PMF) mixture, extracted from orange peels, suppresses the UVB-induced expression of MMP-1 that involves the inhibition of c-jun N-terminal kinase (JNK) activity. Furthermore, the PMF mixture also inhibits the UVB-induced phosphorylation of JNK. Therefore, the results suggest that the PMF mixture suppresses the UVB-induced expression of MMP-1 through the inhibition of JNK phosphorylation and should be useful as an antiphotoageing agent.
authors.affiliation: Advanced Technology Research Lab., NOF Corporation, Tokyo, Japan.
authors.forename: Norihiro
authors.initials: N
authors.lastname: Yoshizaki
authors.affiliation: Advanced Technology Research Lab., NOF Corporation, Tokyo, Japan.
authors.forename: Takahiro
authors.initials: T
authors.lastname: Fujii
authors.affiliation: Advanced Technology Research Lab., NOF Corporation, Tokyo, Japan.
authors.forename: Ron
authors.initials: R
authors.lastname: Hashizume
authors.affiliation: School of Bioscience and Biotechnology, Tokyo University of Technology, Tokyo, Japan.
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Masaki
mesh_terms: D002478:Cells, Cultured; D032084:Citrus sinensis; D047309:Flavones / Q000302:isolation & purification / Q000494:pharmacology; D015870:Gene Expression / Q000187:drug effects / Q000528:radiation effects; D006801:Humans; D048031:JNK Mitogen-Activated Protein Kinases / Q000378:metabolism; D015603:Keratinocytes / Q000187:drug effects / Q000378:metabolism / Q000528:radiation effects; D020781:Matrix Metalloproteinase 1 / Q000235:genetics* / Q000378:metabolism*; D010766:Phosphorylation / Q000187:drug effects / Q000528:radiation effects; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D015595:Skin Aging / Q000187:drug effects* / Q000502:physiology / Q000528:radiation effects*; D014466:Ultraviolet Rays / Q000009:adverse effects*
chemical_list: D047309:Flavones; D010936:Plant Extracts; D012333:RNA, Messenger; D048031:JNK Mitogen-Activated Protein Kinases; C522360:MMP1 protein, human; D020781:Matrix Metalloproteinase 1
keywords: AP-1; JNK; MMP-1; PMF; UV