title: Boundary Element Method for Reconstructing Absorption and Diffusion Coefficients of Biological Tissues in DOT/MicroCT Imaging.
abstract: The functional information, the absorption and diffusion coefficients, as well as the structural information of biological tissues can be provided by the DOT(Diffuse Optical Tomograph)/MicroCT. In this paper, we use boundary element method to calculate the forward problem of DOT based on the structure prior given by the MicroCT, and then we reconstruct the absorption and diffusion coefficients of different biological tissues by the Levenberg-Marquardt algorithm. The method only needs surface meshing, reducing the complexity of calculation; in addition, it reconstructs a single value within an organ, which reduces the ill-posedness of the inverse problem to make reconstruction results have good noise stability. This indicates that the boundary element method-based reconstruction can serve as an new scheme for getting absorption and diffusion coefficients in DOT/MicroCT multimodality imaging.
authors.affiliation: Wuhan National Laboratory for Optoelectronics, Britton Chance Center for Biomedical Photonics, Huazhong University of Science and Technology, Wuhan, 430074, China.|Key Laboratory of Biomedical Photonics of Ministry of Education, Department of Biomedical Engineering, Huazhong University of Science and Technology, Wuhan, 430074, China.
authors.forename: Wenhao
authors.initials: W
authors.lastname: Xie
authors.affiliation: Wuhan National Laboratory for Optoelectronics, Britton Chance Center for Biomedical Photonics, Huazhong University of Science and Technology, Wuhan, 430074, China. ydeng@mail.hust.edu.cn.|Key Laboratory of Biomedical Photonics of Ministry of Education, Department of Biomedical Engineering, Huazhong University of Science and Technology, Wuhan, 430074, China. ydeng@mail.hust.edu.cn.
authors.forename: Yong
authors.initials: Y
authors.lastname: Deng
authors.affiliation: Wuhan National Laboratory for Optoelectronics, Britton Chance Center for Biomedical Photonics, Huazhong University of Science and Technology, Wuhan, 430074, China.|Key Laboratory of Biomedical Photonics of Ministry of Education, Department of Biomedical Engineering, Huazhong University of Science and Technology, Wuhan, 430074, China.
authors.forename: Lichao
authors.initials: L
authors.lastname: Lian
authors.affiliation: Wuhan National Laboratory for Optoelectronics, Britton Chance Center for Biomedical Photonics, Huazhong University of Science and Technology, Wuhan, 430074, China.|Key Laboratory of Biomedical Photonics of Ministry of Education, Department of Biomedical Engineering, Huazhong University of Science and Technology, Wuhan, 430074, China.
authors.forename: Dongmei
authors.initials: D
authors.lastname: Yan
authors.affiliation: Wuhan National Laboratory for Optoelectronics, Britton Chance Center for Biomedical Photonics, Huazhong University of Science and Technology, Wuhan, 430074, China.|Key Laboratory of Biomedical Photonics of Ministry of Education, Department of Biomedical Engineering, Huazhong University of Science and Technology, Wuhan, 430074, China.
authors.forename: Xiaoquan
authors.initials: X
authors.lastname: Yang
authors.affiliation: Britton Chance Center for Biomedical Photonics, Wuhan National Laboratory for Optoelectronics, Huazhong University of Science and Technology, Wuhan, 430074, China.
authors.forename: Qingming
authors.initials: Q
authors.lastname: Luo
mesh_terms: D000465:Algorithms; D003198:Computer Simulation; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D009716:Numerical Analysis, Computer-Assisted; D011237:Predictive Value of Tests; D015203:Reproducibility of Results; D041622:Tomography, Optical / Q000379:methods*; D055114:X-Ray Microtomography / Q000379:methods*
keywords: Absorbing coefficients; Boundary element method; Diffusion coefficients; Image reconstruction; Multimodality imaging