title: Metal-based ethanolamine-derived compounds: a note on their synthesis, characterization and bioactivity.
abstract: Metal-based ethanolamines, (L1)-(L4) coordinated with Co(II), Cu(II), Ni(II) and Zn(II) metals in 1:2 (metal:ligand) molar ratio to produce new compounds have been reported. These compounds were screened for their bactericidal/fungicidal activity against a number of bacterial (Escherichia coli, Shigella flexneri, Pseudomonas aeruginosa, Salmonella typhi, Staphylococcus aureus and Bacillus subtilis) and fungal strains (Trichophyton longifusus, Candida albicans, Aspergillus flavus, Microsporum canis, Fusarium solani and Candida glabrata) alongside against a shrimp species known as Artemia salina. The screening results indicated that metal complexes have significantly higher activity than uncomplexed ligands against one or more bacterial/fungal species due to chelation. The ligand (L4) displayed good bacterial and fungal activity as compared to other ligands. The antibacterial results revealed that the Zn(II) complex (16) of (L4) was found to be the most active complex and Co(II) complex (14) of the same ligand (L4), demonstrated the highest antifungal activity.
authors.affiliation: a Institute of Chemical Sciences, Bahauddin Zakariya University , Multan , Pakistan.
authors.forename: Muhammad
authors.initials: M
authors.lastname: Amjad
authors.affiliation: b Department of Chemistry , Institute of Natural Sciences, University of Gujrat , Gujrat , Pakistan.
authors.forename: Sajjad H
authors.initials: SH
authors.lastname: Sumrra
authors.affiliation: c School of Science & Engineering, Teesside University , Middlesbrough , UK , and.
authors.forename: Muhammad Safwan
authors.initials: MS
authors.lastname: Akram
authors.affiliation: d Department of Chemistry , University of Sargodha , Bhakkar Campus , Pakistan.
authors.forename: Zahid H
authors.initials: ZH
authors.lastname: Chohan
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D019856:Ethanolamine / Q000737:chemistry / Q000494:pharmacology*; D005658:Fungi / Q000187:drug effects; D019216:Metals, Heavy / Q000737:chemistry / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D019216:Metals, Heavy; D009942:Organometallic Compounds; D019856:Ethanolamine
keywords: Antibacterial/antifungal; ethanolamine-derived compounds; metal(II) complexes