title: [Wine consumption and prevention of coronary artery disease].
abstract: There is a J-shaped correlation between the amount of alcohol consumed per day and overall mortality risk and an inverse correlation between the amount of alcohol consumed per day and cardiovascular mortality. The evidence is stronger for men than for women. The correlations are independent of the type of alcoholic beverage predominantly consumed. Possible mechanisms explaining the cardioprotective, antiatherosclerotic effects of moderate alcohol consumption are inhibition of platelet aggregation, increase in serum high density lipoprotein (HDL) levels and prevention of diabetes mellitus. The two latter mechanisms can also explain a delayed progression of atherosclerosis due to alcohol consumption. The beneficial effects are counteracted by detrimental effects of alcohol on the incidence of cancer diseases, liver cirrhosis, violence and accidents; therefore, alcohol consumption in general cannot be recommended for prevention of cardiovascular diseases.
authors.affiliation: Marienkrankenhaus Soest, Widumgasse 5, 59494, Soest, Deutschland. m.flesch@mkh-soest.de.
authors.forename: M
authors.initials: M
authors.lastname: Flesch
authors.affiliation: Marienkrankenhaus Soest, Widumgasse 5, 59494, Soest, Deutschland.
authors.forename: S
authors.initials: S
authors.lastname: Morbach
authors.affiliation: Klinik III für Innere Medizin, Universität zu Köln, Köln, Deutschland.
authors.forename: E
authors.initials: E
authors.lastname: Erdmann
authors.affiliation: Marienkrankenhaus Soest, Widumgasse 5, 59494, Soest, Deutschland.
authors.forename: D
authors.initials: D
authors.lastname: Bulut
mesh_terms: D000428:Alcohol Drinking / Q000401:mortality*; D015984:Causality; D015897:Comorbidity; D003324:Coronary Artery Disease / Q000401:mortality* / Q000517:prevention & control*; D004035:Diet Therapy / Q000379:methods*; D000431:Ethanol / Q000627:therapeutic use*; D019317:Evidence-Based Medicine; D006801:Humans; D015994:Incidence; D040242:Risk Reduction Behavior; D015996:Survival Rate; D016896:Treatment Outcome; D014920:Wine
chemical_list: D000431:Ethanol
keywords: Alcohol consumption; Atherosclerosis; Coronary artery disease; HDL cholesterol; Platelet aggregation