title: Skin Diseases Modeling using Combined Tissue Engineering and Microfluidic Technologies.
abstract: In recent years, both tissue engineering and microfluidics have significantly contributed in engineering of in vitro skin substitutes to test the penetration of chemicals or to replace damaged skins. Organ-on-chip platforms have been recently inspired by the integration of microfluidics and biomaterials in order to develop physiologically relevant disease models. However, the application of organ-on-chip on the development of skin disease models is still limited and needs to be further developed. The impact of tissue engineering, biomaterials and microfluidic platforms on the development of skin grafts and biomimetic in vitro skin models is reviewed. The integration of tissue engineering and microfluidics for the development of biomimetic skin-on-chip platforms is further discussed, not only to improve the performance of present skin models, but also for the development of novel skin disease platforms for drug screening processes.
authors.affiliation: Department of Chemical and Petroleum Engineering, Sharif University of Technology, Azadi Ave, Tehran, Iran.
authors.forename: Mohammad Hossein
authors.initials: MH
authors.lastname: Mohammadi
authors.affiliation: Department of Materials Science and Engineering, Sharif University of Technology, Azadi Ave, Tehran, Iran.
authors.forename: Behnaz
authors.initials: B
authors.lastname: Heidary Araghi
authors.affiliation: Department of Chemical and Petroleum Engineering, Sharif University of Technology, Azadi Ave, Tehran, Iran.
authors.forename: Vahid
authors.initials: V
authors.lastname: Beydaghi
authors.affiliation: Department of Chemical and Petroleum Engineering, Sharif University of Technology, Azadi Ave, Tehran, Iran.
authors.forename: Armin
authors.initials: A
authors.lastname: Geraili
authors.affiliation: Department of Chemical and Petroleum Engineering, Sharif University of Technology, Azadi Ave, Tehran, Iran.
authors.forename: Farshid
authors.initials: F
authors.lastname: Moradi
authors.affiliation: Department of Electrical Engineering, Sharif University of Technology, Azadi Ave, Tehran, Iran.
authors.forename: Parya
authors.initials: P
authors.lastname: Jafari
authors.affiliation: Department of Mechanical and Manufacturing Engineering, Center for Bioengineering Research and Education, University of Calgary, 2500 University Drive NW, Calgary, AB, Canada.
authors.forename: Mohsen
authors.initials: M
authors.lastname: Janmaleki
authors.affiliation: Department of Mechanical Engineering, and Center for Biomedical Research, University of Victoria, Victoria, BC, Canada.
authors.forename: Karolina Papera
authors.initials: KP
authors.lastname: Valente
authors.affiliation: Department of Mechanical Engineering, and Center for Biomedical Research, University of Victoria, Victoria, BC, Canada.
authors.forename: Mohsen
authors.initials: M
authors.lastname: Akbari
authors.affiliation: Department of Mechanical and Manufacturing Engineering, Center for Bioengineering Research and Education, University of Calgary, 2500 University Drive NW, Calgary, AB, Canada. amir.sanatinezhad@ucalgary.ca.
authors.forename: Amir
authors.initials: A
authors.lastname: Sanati-Nezhad
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000494:pharmacology / Q000627:therapeutic use; D032701:Biomimetics / Q000379:methods; D004353:Drug Evaluation, Preclinical / Q000379:methods; D006801:Humans; D046210:Microfluidic Analytical Techniques / Q000379:methods; D044085:Microfluidics / Q000379:methods; D008954:Models, Biological; D012871:Skin Diseases / Q000188:drug therapy / Q000503:physiopathology* / Q000628:therapy*; D023822:Tissue Engineering / Q000379:methods
chemical_list: D001672:Biocompatible Materials
keywords: microfluidics; organ-on-chip; skin disease; tissue engineering