title: A review on the diagnosis and treatment of patients with clinically nonfunctioning pituitary adenoma by the Neuroendocrinology Department of the Brazilian Society of Endocrinology and Metabolism.
abstract: Clinically nonfunctioning pituitary adenomas (NFPA) are the most common pituitary tumors after prolactinomas. The absence of clinical symptoms of hormonal hypersecretion can contribute to the late diagnosis of the disease. Thus, the majority of patients seek medical attention for signs and symptoms resulting from mass effect, such as neuro-ophthalmologic symptoms and hypopituitarism. Other presentations include pituitary apoplexy or an incidental finding on imaging studies. Mass effect and hypopituitarism impose high morbidity and mortality. However, early diagnosis and effective treatment minimizes morbidity and mortality. In this publication, the goal of the Neuroendocrinology Department of the Brazilian Society of Endocrinology and Metabolism is to provide a review of the diagnosis and treatment of patients with NFPA, emphasizing that the treatment should be performed in reference centers. This review is based on data published in the literature and the authors' experience. Arch Endocrinol Metab. 2016;60(4):374-90.
authors.affiliation: Serviço de Endocrinologia, Hospital Universitário Clementino Fraga Filho, Universidade Federal do Rio de Janeiro (HUCFF-UFRJ), Rio de Janeiro, RJ, Brasil.|Serviço de Endocrinologia, Hospital Federal da Lagoa, Rio de Janeiro, RJ, Brasil.
authors.forename: Leonardo
authors.initials: L
authors.lastname: Vieira
authors.affiliation: Serviço de Endocrinologia e Metabologia, Hospital de Clínicas, Universidade Federal do Paraná (SEMPR), Curitiba, PR, Brasil.
authors.forename: Cesar L
authors.initials: CL
authors.lastname: Boguszewski
authors.affiliation: Centro de Endocrinologia e Diabetes de Joinville (Endoville), Joinville, SC, Brasil.
authors.forename: Luiz Antônio de
authors.initials: LA
authors.lastname: Araújo
authors.affiliation: Serviço de Endocrinologia, Hospital das Clínicas, Faculdade de Medicina da Universidade de São Paulo (FMUSP), São Paulo, SP, Brasil.
authors.forename: Marcello D
authors.initials: MD
authors.lastname: Bronstein
authors.affiliation: Serviço de Endocrinologia e Metabologia, Santa Casa de Belo Horizonte, Belo Horizonte, MG, Brasil.
authors.forename: Paulo Augusto C
authors.initials: PA
authors.lastname: Miranda
authors.affiliation: Divisão de Neurocirurgia Funcional, Instituto de Psiquiatria do Hospital das Clínicas, Faculdade de Medicina da Universidade de São Paulo (IPq-HC-FMUSP), São Paulo, SP, Brasil.
authors.forename: Nina R de C
authors.initials: NR
authors.lastname: Musolino
authors.affiliation: Serviço de Endocrinologia do Hospital Universitário de Brasília, Universidade de Brasília (UnB), Brasília, DF, Brasil.
authors.forename: Luciana A
authors.initials: LA
authors.lastname: Naves
authors.affiliation: Serviço de Endocrinologia, Hospital das Clínicas, Universidade Federal de Pernambuco (UFPE), Recife, PE, Brasil.
authors.forename: Lucio
authors.initials: L
authors.lastname: Vilar
authors.affiliation: Serviço de Endocrinologia, Hospital das Clínicas, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, MG, Brasil.
authors.forename: Antônio
authors.initials: A
authors.lastname: Ribeiro-Oliveira
authors.affiliation: Serviço de Endocrinologia, Hospital Universitário Clementino Fraga Filho, Universidade Federal do Rio de Janeiro (HUCFF-UFRJ), Rio de Janeiro, RJ, Brasil.|Unidade de Neuroendocrinologia, Instituto Estadual do Cérebro Paulo Niemeyer, Rio de Janeiro, RJ, Brasil.
authors.forename: Mônica R
authors.initials: MR
authors.lastname: Gadelha
mesh_terms: D000236:Adenoma / Q000175:diagnosis* / Q000628:therapy*; D000970:Antineoplastic Agents / Q000627:therapeutic use; D001938:Brazil; D042241:Early Diagnosis; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D009452:Neuroendocrinology; D010911:Pituitary Neoplasms / Q000175:diagnosis* / Q000628:therapy*; D012307:Risk Factors; D012955:Societies, Medical
chemical_list: D000970:Antineoplastic Agents