title: Hepatitis E Pathogenesis.
abstract: Although most hepatitis E virus (HEV) infections are asymptomatic, some can be severe, causing fulminant hepatitis and extra-hepatic manifestations, including neurological and kidney injuries. Chronic HEV infections may also occur in immunocompromised patients. This review describes how our understanding of the pathogenesis of HEV infection has progressed in recent years.
authors.affiliation: INSERM, UMR1043, Department of Virology, CHU Purpan, Université Paul Sabatier, 31000 Toulouse, France. lhomme.s@chu-toulouse.fr.
authors.forename: Sébastien
authors.initials: S
authors.lastname: Lhomme
authors.affiliation: INSERM, UMR1043, Department of Virology, CHU Purpan, Université Paul Sabatier, 31000 Toulouse, France. marion-olivier@hotmail.fr.|INSERM, UMR1043, Department of Nephrology, Dialysis and Organ Transplantation, CHU Rangueil, Université Paul Sabatier, 31000 Toulouse, France. marion-olivier@hotmail.fr.
authors.forename: Olivier
authors.initials: O
authors.lastname: Marion
authors.affiliation: INSERM, UMR1043, Department of Virology, CHU Purpan, Université Paul Sabatier, 31000 Toulouse, France. abravanel.f@chu-toulouse.fr.
authors.forename: Florence
authors.initials: F
authors.lastname: Abravanel
authors.affiliation: INSERM, UMR1043, Department of Virology, CHU Purpan, Université Paul Sabatier, 31000 Toulouse, France. chapuy-regaud.s@chu-toulouse.fr.
authors.forename: Sabine
authors.initials: S
authors.lastname: Chapuy-Regaud
authors.affiliation: INSERM, UMR1043, Department of Nephrology, Dialysis and Organ Transplantation, CHU Rangueil, Université Paul Sabatier, 31000 Toulouse, France. kamar.n@chu-toulouse.fr.
authors.forename: Nassim
authors.initials: N
authors.lastname: Kamar
authors.affiliation: INSERM, UMR1043, Department of Virology, CHU Purpan, Université Paul Sabatier, 31000 Toulouse, France. izopet.j@chu-toulouse.fr.
authors.forename: Jacques
authors.initials: J
authors.lastname: Izopet
mesh_terms: D016751:Hepatitis E / Q000473:pathology* / Q000503:physiopathology*; D016752:Hepatitis E virus / Q000472:pathogenicity*; D054884:Host-Pathogen Interactions; D006801:Humans
keywords: chronic infection; extra-hepatic manifestation; fulminant hepatitis; hepatitis E virus; pathogenesis