title: Game of Trans-Kingdom Effectors.
abstract: TplE, a type VI secreted (phospho)lipase, has been identified as the third trans-kingdom effector of Pseudomonas aeruginosa, targeting both prokaryotic and eukaryotic hosts. Indeed, TplE triggers the killing of bacterial competitors and promotes autophagy in epithelial cells once localized to the endoplasmic reticulum.
authors.affiliation: Aix-Marseille Univ, CNRS, LISM, Laboratoire d'Ingénierie des Systèmes Macromoléculaires-UMR7255, Institut de Microbiologie de la Méditerranée, Marseille, France. Electronic address: bleves@imm.cnrs.fr.
authors.forename: Sophie
authors.initials: S
authors.lastname: Bleves
mesh_terms: D001343:Autophagy; D059865:Endoplasmic Reticulum Stress; D004847:Epithelial Cells / Q000382:microbiology / Q000473:pathology; D054884:Host-Pathogen Interactions; D011550:Pseudomonas aeruginosa / Q000201:enzymology / Q000378:metabolism*; D000069376:Type VI Secretion Systems / Q000378:metabolism*
chemical_list: D000069376:Type VI Secretion Systems
keywords: Pseudomonas aeruginosa; antibacterial; autophagy; endoplasmic reticulum stress; trans-kingdom effector; type VI secretion system