title: Non-human primate models of SIV infection and CNS neuropathology.
abstract: Non-human primate models of AIDS and neuroAIDS are the premiere model of HIV infection of the CNS and neuropathogenesis. This review discusses current SIV infection models of neuroAIDS emphasizing findings in the last two years. Consistent in these findings is the interplay between host factors that regulate immune responses to virus and viral replication. Several rapid models of AIDS with consistent CNS pathogenesis exist, each of which modulates by antibody treatment or viruses that cause rapid immune suppression and replicate well in macrophages. Consistent in all of these models are data underscoring the importance of monocyte and macrophage activation, infection and accumulation in the CNS.
authors.affiliation: Department of Biology, Boston College, Chestnut Hill, MA, USA. Electronic address: williauy@bc.edu.
authors.forename: Kenneth
authors.initials: K
authors.lastname: Williams
authors.affiliation: Tulane National Primate Research Center, Covington, LA, USA.
authors.forename: Andrew
authors.initials: A
authors.lastname: Lackner
authors.affiliation: Department of Biology, Boston College, Chestnut Hill, MA, USA.
authors.forename: Jaclyn
authors.initials: J
authors.lastname: Mallard
mesh_terms: D015526:AIDS Dementia Complex / Q000276:immunology / Q000473:pathology / Q000821:virology; D000818:Animals; D002490:Central Nervous System / Q000276:immunology / Q000473:pathology* / Q000821:virology*; D004195:Disease Models, Animal; D018792:Encephalitis, Viral / Q000276:immunology / Q000473:pathology; D006801:Humans; D008253:Macaca mulatta; D008264:Macrophages / Q000821:virology; D009000:Monocytes / Q000821:virology; D016097:Simian Acquired Immunodeficiency Syndrome / Q000276:immunology / Q000821:virology; D015302:Simian Immunodeficiency Virus / Q000502:physiology*; D014779:Virus Replication