title: Clinical Effectiveness, Safety Profile, and Pharmacokinetics of Daptomycin in Pediatric Patients: A Systematic Review.
abstract: Infections by Gram-positive pathogens pose a public health risk, especially due to increasing antibiotic resistance. Daptomycin has efficacy against most clinically important Gram-positive bacteria. Although experience regarding use of daptomycin in adults is increasing, studies on pediatric populations are limited. We aimed to evaluate the efficacy, safety, and pharmacokinetics of daptomycin in pediatric settings. We searched MEDLINE and Clinicaltrials.gov (through April 2016) and included 29 original studies in the final analysis. Available evidence suggests that daptomycin in pediatric patients has a favorable safety and tolerability profile and is an efficacious alternative for treatment of Gram-positive bacteremia, endocarditis, and infections of the skin, soft tissues, joints, and bones, especially when resistant strains are involved. However, future studies need to address several issues to determine the optimal dose and various pharmacokinetic parameters in different pediatric age groups.
authors.affiliation: Infectious Diseases Working Group, Society of Junior Doctors, Athens.|University of Crete School of Medicine, Heraklion, Crete.
authors.forename: Spyridon A
authors.initials: SA
authors.lastname: Karageorgos
authors.affiliation: Infectious Diseases Working Group, Society of Junior Doctors, Athens.|Laboratory of Biomathematics, University of Thessaly School of Medicine, Larissa.
authors.forename: Michael
authors.initials: M
authors.lastname: Miligkos
authors.affiliation: Infectious Diseases Working Group, Society of Junior Doctors, Athens.|First Department of Paediatrics, "Aghia Sophia" Children's Hospital, University of Athens, Greece.
authors.forename: Maria
authors.initials: M
authors.lastname: Dakoutrou
authors.affiliation: Infectious Diseases Working Group, Society of Junior Doctors, Athens.|Nicosia Polyclinic, Nicosia, Cyprus.
authors.forename: Constantinos
authors.initials: C
authors.lastname: Tsioutis
mesh_terms: D000900:Anti-Bacterial Agents / Q000493:pharmacokinetics* / Q000627:therapeutic use*; D002648:Child; D017576:Daptomycin / Q000493:pharmacokinetics* / Q000627:therapeutic use*; D016908:Gram-Positive Bacterial Infections / Q000188:drug therapy*; D006801:Humans
chemical_list: D000900:Anti-Bacterial Agents; D017576:Daptomycin
keywords: daptomycin; pediatric; systematic review