title: The influence of oral administration of rosuvastatin on calvarial bone healing in rats.
abstract: The purpose of this study is to investigate the potential of the systemic administration of different doses of rosuvastatin (RSV) on autogenous grafted critical-sized cortical bone defects. Twenty-four rats were divided into three groups: Group C (control), Group RSV-2 and Group RSV-5. A 5-mm diameter critical-size defect was created in the calvarium of each animal. In Group C, the defect was filled by autogenous graft only and rats were given saline solution with oral gavage for 28 days. In Group RSV-2 defects were filled with autogenous graft and rats were given 2 mg/kg rosuvastatin with oral gavage for 28 days. In Group RSV-5 defects were filled with autogenous graft and rats were given 5 mg/kg rosuvastatin with oral gavage for 28 days. All animals were euthanized at 28 days postoperative. Stereologic and micro-CT analyses were performed. New bone area (NBA) and connective tissue volumes were measured. Stereologic analysis showed that Group RSV-5 and RSV-2 had significantly more new bone at 4 weeks compared with group C. Connective tissue volumes were also significantly higher in RSV applicated groups. New bone and connective tissue volumes' difference were not statistically significant between RSV groups. Micro-CT results were similar with stereologic analyses. Orally administered RSV enhances bone regeneration in critical size calvarial rat defects filled with autogenous graft furthermore possible inflammatory effect should be investigated.
authors.affiliation: Department of Oral and Maxillofacial Surgery, Bülent Ecevit University, Zonguldak, Turkey. Electronic address: akifturer@gmail.com.
authors.forename: Akif
authors.initials: A
authors.lastname: Türer
authors.affiliation: Department of Periodontology, Bülent Ecevit University, Zonguldak, Turkey.
authors.forename: Çiğdem
authors.initials: Ç
authors.lastname: Coşkun Türer
authors.affiliation: Department of Oral and Maxillofacial Surgery, Bülent Ecevit University, Zonguldak, Turkey.
authors.forename: M Cenk
authors.initials: MC
authors.lastname: Durmuşlar
authors.affiliation: Department of Periodontology, Bülent Ecevit University, Zonguldak, Turkey.
authors.forename: Umut
authors.initials: U
authors.lastname: Balli
authors.affiliation: Department of Histology and Embryology, Ondokuz Mayıs University, Samsun, Turkey.
authors.forename: M Emin
authors.initials: ME
authors.lastname: Önger
mesh_terms: D000284:Administration, Oral; D000818:Animals; D001861:Bone Regeneration / Q000187:drug effects*; D004195:Disease Models, Animal; D051381:Rats; D017208:Rats, Wistar; D000068718:Rosuvastatin Calcium / Q000008:administration & dosage* / Q000494:pharmacology*; D012886:Skull / Q000000981:diagnostic imaging / Q000601:surgery*; D014945:Wound Healing / Q000187:drug effects*; D055114:X-Ray Microtomography
chemical_list: D000068718:Rosuvastatin Calcium
keywords: Bone healing; Micro CT; Rosuvastatin; Stereological