title: ALK rearrangements-associated renal cell carcinoma (RCC) with unique pathological features in an adult.
abstract: We report an exceptional case of renal cell carcinoma (RCC) associated with ALK translocation in an adult. The tumor was located in the left kidney and measured 4cm. The tumor was composed of sheets of large eosinophilic cells with frequently intracytoplasmic vacuoles. The nuclei were large with a nucleolar grade 3. At immunohistochemistry, tumor cells were diffusely positive for PAX8 and vimentin and focally stained with CK7. ALK immunostaining was diffuse and fluorescent in situ hybridization showed a rearrangement of ALK in numerous tumor cells. To date, less than 17 cases of RCCs with ALK rearrangements are reported in children and adults. The prognosis remains uncertain but ALK rearrangement may be of potential value for target therapy with crizotinib.
authors.affiliation: Department of Pathology, Univ. Lille, CHU, F-59000 Lille, France.
authors.forename: Marie
authors.initials: M
authors.lastname: Jeanneau
authors.affiliation: Department of Pathology, Univ. Lille, CHU, F-59000 Lille, France.
authors.forename: Valerie
authors.initials: V
authors.lastname: Gregoire
authors.affiliation: Sipath-Unilabs Laboratory, 63063 Clermont-Ferrand, France.
authors.forename: Claude
authors.initials: C
authors.lastname: Desplechain
authors.affiliation: Department of Biochemistry and Molecular Biology, Univ. Lille, CHU, F-59000 Lille, France.
authors.forename: Fabienne
authors.initials: F
authors.lastname: Escande
authors.affiliation: Department of Surgery, CH, 28100 Dreux, France.
authors.forename: Dan Petre
authors.initials: DP
authors.lastname: Tica
authors.affiliation: Department of Pathology, Univ. Lille, CHU, F-59000 Lille, France.
authors.forename: Sebastien
authors.initials: S
authors.lastname: Aubert
authors.affiliation: Department of Pathology, Univ. Lille, CHU, F-59000 Lille, France. Electronic address: xavier.leroy@chru-lille.fr.
authors.forename: Xavier
authors.initials: X
authors.lastname: Leroy
mesh_terms: D000328:Adult; D000077548:Anaplastic Lymphoma Kinase; D014408:Biomarkers, Tumor / Q000032:analysis; D002292:Carcinoma, Renal Cell / Q000235:genetics* / Q000473:pathology*; D005260:Female; D015321:Gene Rearrangement; D006801:Humans; D007150:Immunohistochemistry; D017404:In Situ Hybridization, Fluorescence; D007680:Kidney Neoplasms / Q000235:genetics* / Q000473:pathology*; D020794:Receptor Protein-Tyrosine Kinases / Q000235:genetics*
chemical_list: D014408:Biomarkers, Tumor; C000626173:ALK protein, human; D000077548:Anaplastic Lymphoma Kinase; D020794:Receptor Protein-Tyrosine Kinases
keywords: ALK; Fluorescent in situ hybridization; Kidney; Renal cell carcinoma