title: Outcomes after surgical salvage for recurrent oropharyngeal squamous cell carcinoma.
abstract: Compare human papillomavirus (HPV) status and outcomes in patients undergoing salvage surgical resection for a recurrent oropharyngeal squamous cell carcinoma (OPSCC).
  
  
  
  Case series with chart review (2005-2013).
  
  
  
  Sixty-nine patients were identified who underwent salvage surgical resection for a recurrent OPSCC after primary radiation therapy. There was no difference in the incidence of HPV negative (52%; n=36) and HPV positive (48%; n=33) tumors. The mean time from completion of radiation therapy to salvage surgery was 2.4years. At the time of salvage operation, there was no correlation with HPV status, as assessed by p16 immunohistochemistry, and lymph node metastases (p=0.21), T classification (p=0.22), tracheostomy dependence (p=0.59), gastrostomy tube dependence (p=0.82), or duration from radiation therapy (p=0.63). The majority of patients were either current or former tobacco users (75%) and of the HPV positive patients, 66% were tobacco users. Development of a new recurrence after salvage surgical resection occurred in 33% of patients (n=26), with a higher incidence in patients with HPV negative disease (52%, n=17/33; p=0.05). The overall 2- and 5-year survival rates were 0.47 and 0.23. There was no difference in overall survival rates when stratified by HPV status or tobacco use. Decreased overall 5-year survival rates did correlate with cervical lymph node metastases (p=0.01), advanced tumor stage (p=0.04) and dependence on gastrostomy tube postoperatively (p=0.04).
  
  
  
  This study found cervical lymph node metastases, clinical stage, and dependence on gastrostomy tube for nutrition to have the greatest impact on overall survival for patients with recurrent OPSCC.
authors.affiliation: Department of Otolaryngology - Head and Neck Surgery, University of Alabama at Birmingham, Birmingham, AL, United States.
authors.forename: Larissa
authors.initials: L
authors.lastname: Sweeny
authors.affiliation: Department of Otolaryngology - Head and Neck Surgery, Stanford University, Stanford, CA, United States.
authors.forename: Eben L
authors.initials: EL
authors.lastname: Rosenthal
authors.affiliation: Department of Otolaryngology - Head and Neck Surgery, University of Alabama at Birmingham, Birmingham, AL, United States.
authors.forename: Lisa
authors.initials: L
authors.lastname: Clemons
authors.affiliation: Department of Pathology, University of Alabama at Birmingham, Birmingham, AL, United States.
authors.forename: Todd M
authors.initials: TM
authors.lastname: Stevens
authors.affiliation: Department of Pathology, University of Alabama at Birmingham, Birmingham, AL, United States.
authors.forename: Eleanor R
authors.initials: ER
authors.lastname: Cook McIntosh
authors.affiliation: Department of Otolaryngology - Head and Neck Surgery, University of Alabama at Birmingham, Birmingham, AL, United States. Electronic address: wcarroll@uabmc.edu.
authors.forename: William R
authors.initials: WR
authors.lastname: Carroll
mesh_terms: D000328:Adult; D000368:Aged; D052685:Alphapapillomavirus / Q000302:isolation & purification; D002294:Carcinoma, Squamous Cell / Q000473:pathology / Q000601:surgery* / Q000821:virology; D005260:Female; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D009959:Oropharyngeal Neoplasms / Q000473:pathology / Q000601:surgery* / Q000821:virology; D016879:Salvage Therapy; D016896:Treatment Outcome
keywords: HPV; Oropharyngeal cancer; Recurrence; Surgical salvage