title: High-frequency stimulation-induced synaptic potentiation in dorsal and ventral CA1 hippocampal synapses: the involvement of NMDA receptors, mGluR5, and (L-type) voltage-gated calcium channels.
abstract: The ability of the ventral hippocampus (VH) for long-lasting long-term potentiation (LTP) and the mechanisms underlying its lower ability for short-lasting LTP compared with the dorsal hippocampus (DH) are unknown. Using recordings of field excitatory postsynaptic potentials (EPSPs) from the CA1 field of adult rat hippocampal slices, we found that 200-Hz stimulation induced nondecremental LTP that was maintained for at least 7 h and was greater in the DH than in the VH. The interaction of NMDA receptors with L-type voltage-dependent calcium channels appeared to be more effective in the DH than in the VH. Furthermore, the LTP was significantly enhanced in the DH only, between 2 and 5 h post-tetanus. Furthermore, the mGluR5 contributed to the post-tetanic potentiation more in the VH than in the DH.
authors.affiliation: Laboratory of Physiology, Department of Medicine, University of Patras, 26504, Rion, Greece cepapath@upatras.gr.
authors.forename: Costas
authors.initials: C
authors.lastname: Papatheodoropoulos
authors.affiliation: Laboratory of Physiology, Department of Medicine, University of Patras, 26504, Rion, Greece.
authors.forename: Stylianos
authors.initials: S
authors.lastname: Kouvaros
mesh_terms: D000818:Animals; D056547:CA1 Region, Hippocampal / Q000502:physiology*; D002121:Calcium Channel Blockers / Q000008:administration & dosage; D020746:Calcium Channels, L-Type / Q000502:physiology*; D004558:Electric Stimulation; D018691:Excitatory Amino Acid Antagonists / Q000008:administration & dosage; D019706:Excitatory Postsynaptic Potentials; D017774:Long-Term Potentiation; D008297:Male; D009553:Nimodipine / Q000008:administration & dosage; D010879:Piperazines / Q000008:administration & dosage; D010880:Piperidines / Q000008:administration & dosage; D017208:Rats, Wistar; D064529:Receptor, Metabotropic Glutamate 5 / Q000037:antagonists & inhibitors / Q000502:physiology*; D016194:Receptors, N-Methyl-D-Aspartate / Q000037:antagonists & inhibitors / Q000502:physiology*; D013844:Thiazoles / Q000008:administration & dosage
chemical_list: C541428:3-((2-methyl-1,3-thiazol-4-yl)ethynyl)piperidine; D002121:Calcium Channel Blockers; D020746:Calcium Channels, L-Type; D018691:Excitatory Amino Acid Antagonists; C578937:Grm5 protein, rat; D010879:Piperazines; D010880:Piperidines; D064529:Receptor, Metabotropic Glutamate 5; D016194:Receptors, N-Methyl-D-Aspartate; D013844:Thiazoles; D009553:Nimodipine; C050592:3-(2-carboxypiperazin-4-yl)propyl-1-phosphonic acid