title: Adaptation through proportion.
abstract: Adaptation is a ubiquitous feature in biological sensory and signaling networks. It has been suggested that adaptive systems may follow certain simple design principles across diverse organisms, cells and pathways. One class of networks that can achieve adaptation utilizes an incoherent feedforward control, in which two parallel signaling branches exert opposite but proportional effects on the output at steady state. In this paper, we generalize this adaptation mechanism by establishing a steady-state proportionality relationship among a subset of nodes in a network. Adaptation can be achieved by using any two nodes in the sub-network to respectively regulate the output node positively and negatively. We focus on enzyme networks and first identify basic regulation motifs consisting of two and three nodes that can be used to build small networks with proportional relationships. Larger proportional networks can then be constructed modularly similar to LEGOs. Our method provides a general framework to construct and analyze a class of proportional and/or adaptation networks with arbitrary size, flexibility and versatile functional features.
authors.affiliation: School of Physics, Peking University, Beijing 100871, People's Republic of China. Center for Quantitative Biology, Peking University, Beijing 100871, People's Republic of China.
authors.forename: Liyang
authors.initials: L
authors.lastname: Xiong
authors.forename: Wenjia
authors.initials: W
authors.lastname: Shi
authors.forename: Chao
authors.initials: C
authors.lastname: Tang
mesh_terms: D000220:Adaptation, Biological; D053263:Gene Regulatory Networks; D008957:Models, Genetic; D049490:Systems Biology