title: Rapid Treatment of Subungual Onychomycosis Using Controlled Micro Nail Penetration and Terbinafine Solution.
abstract: Onychomycosis continues to be a common and intractable problem in adults, often responding poorly to topical treatment due to limited drug penetration of the nail plate. Improving penetration has been attempted previously by chemical and physical means with some success. The authors present three cases of toenail onychomycosis treated topical terbinafine 1% solution using controlled micro-penetration of the nail using a novel intelligent nail drill system which is able to drill nail plate without penetrating the delicate nail bed beneath. The cases illustrate how the device has been successfully employed to deliver the anti-fungal drug directly and rapidly to the site of infection with minimal side effects or complications, whilst maintaining the nail integrity.<br /><br /> <em>J Drugs Dermatol</em>. 2016;15(8):974-978.
authors.forename: Ivan
authors.initials: I
authors.lastname: Bristow
authors.forename: Robert
authors.initials: R
authors.lastname: Baran
authors.forename: Michelle
authors.initials: M
authors.lastname: Score
mesh_terms: D000287:Administration, Topical; D000935:Antifungal Agents / Q000008:administration & dosage*; D005533:Foot Dermatoses / Q000175:diagnosis / Q000188:drug therapy*; D006801:Humans; D009281:Naphthalenes / Q000008:administration & dosage*; D014009:Onychomycosis / Q000175:diagnosis / Q000188:drug therapy*; D010539:Permeability / Q000187:drug effects; D019999:Pharmaceutical Solutions / Q000008:administration & dosage*; D000077291:Terbinafine; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D000935:Antifungal Agents; D009281:Naphthalenes; D019999:Pharmaceutical Solutions; D000077291:Terbinafine