title: Does the Preoperative Administration of Steroids Reduce Intraoperative Bleeding during Endoscopic Surgery of Nasal Polyps?
abstract: Corticosteroids are frequently used in a range of otorhinolaryngologic conditions due to their anti-inflammatory and antiedematous properties. In this meta-analysis, we aimed to assess the role of preoperative steroids for attenuating intraoperative bleeding during endoscopic sinus surgery among patients with nasal polyps.
  
  
  
  PubMed, SCOPUS, EMBASE, the Web of Science, and Cochrane database.
  
  
  
  Literature was screened from January 1980 to January 2016. Five articles comparing patients who were preoperatively administered steroids (steroid groups) with patients who received a placebo or no treatment (control group) were included for analysis, which encompassed intraoperative bleeding, endoscopic surgical field visibility, operative time, and side effects during endoscopic sinus surgery.
  
  
  
  Intraoperative bleeding and operative time during endoscopic sinus surgery in the steroid group were significantly reduced as compared with the control group. Additionally, the preoperative administration of steroids had a significant effect on improving endoscopic surgical field visibility during sinus surgery. There were no significant adverse effects reported in the enrolled studies. In subgroup analyses of these results, steroids showed similar effects on intraoperative bleeding regardless of administration type (topical or systemic).
  
  
  
  This study demonstrated that the preoperative administration of steroids in patients with nasal polyps could effectively reduce intraoperative bleeding. However, the duration of treatment and dosing standard require further investigation, and more trials need to be included.
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
authors.forename: Se Hwan
authors.initials: SH
authors.lastname: Hwang
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
authors.forename: Jae Hyun
authors.initials: JH
authors.lastname: Seo
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
authors.forename: Young Hoon
authors.initials: YH
authors.lastname: Joo
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea entkjm@catholic.ac.kr.
authors.forename: Jun Myung
authors.initials: JM
authors.lastname: Kang
mesh_terms: D016063:Blood Loss, Surgical / Q000517:prevention & control*; D005938:Glucocorticoids / Q000008:administration & dosage*; D006801:Humans; D007828:Laryngoscopy; D009298:Nasal Polyps / Q000601:surgery*; D061646:Operative Time; D011300:Preoperative Care / Q000379:methods; D016896:Treatment Outcome
chemical_list: D005938:Glucocorticoids
keywords: bleeding; meta-analysis; nasal polyp; operative time; steroid; surgical field