title: Combined heart-liver transplantation: Indications, outcomes and current experience.
abstract: Combined heart-liver transplantation is a rare, life-saving procedure that treats complex and often fatal diseases including familial amyloidosis polyneuropathy and late stage congenital heart disease status-post previous repair. There were 159 combined heart-liver transplantations performed between January 1, 1988 and October 3, 2014 in the United States. A multitude of potential techniques to be used for combined heart and liver transplant including: orthotopic heart transplant (OHT) and orthotopic liver transplant (OLT) on full cardiopulmonary bypass (CPB), OHT with CPB and OLT with venovenous bypass (VVB), OHT with CPB and OLT without VVB, en-bloc technique and sequential transplantation. Outcomes of combined heart-liver transplant have been demonstrated to be comparable to outcomes of isolated heart and isolated liver transplant. The liver graft may provide some tolerance of other allografts.
authors.affiliation: Department of Surgery, The Ohio State University Wexner Medical Center, Columbus, OH, USA.
authors.forename: Eliza W
authors.initials: EW
authors.lastname: Beal
authors.affiliation: Department of Internal Medicine, Division of Gastroenterology, Hepatology and Nutrition, The Ohio State Wexner Medical Center, Columbus, OH, USA.
authors.forename: Khalid
authors.initials: K
authors.lastname: Mumtaz
authors.affiliation: Departments of Pediatrics and Internal Medicine, The Ohio State University College of Medicine, Columbus, OH, USA.
authors.forename: Don
authors.initials: D
authors.lastname: Hayes
authors.affiliation: Department of Surgery, The Ohio State University Wexner Medical Center, Columbus, OH, USA; Division of Cardiothoracic Surgery, Department of Surgery, The Ohio State University Wexner Medical Center, Columbus, OH, USA.
authors.forename: Bryan A
authors.initials: BA
authors.lastname: Whitson
authors.affiliation: Department of Surgery, The Ohio State University Wexner Medical Center, Columbus, OH, USA; Division of Transplantation Surgery, Department of Surgery, The Ohio State University Wexner Medical Center, Columbus, OH, USA. Electronic address: Sylvester.Black@osumc.edu.
authors.forename: Sylvester M
authors.initials: SM
authors.lastname: Black
mesh_terms: D016027:Heart Transplantation; D006801:Humans; D016031:Liver Transplantation; D016896:Treatment Outcome