title: [IMMUNOGENICITY AND PROTECTIVE EFFICIENCY OF BCG IN COMBINATION WITH DNA VACCINE IN A MURINE TUBERCULOSIS MODEL].
abstract: An acute murine tuberculosis model has demonstrated that double intramuscular injection of DNA vaccine that expresses protective mycobacterium Ag85B protein after oral BCG vaccination caused a significant mycobacterial load reduction in the organs of infected animals and an increase in the survival of mice.
mesh_terms: D000276:Adjuvants, Immunologic / Q000494:pharmacology; D000818:Animals; D000942:Antigens, Bacterial / Q000276:immunology; D001500:BCG Vaccine / Q000494:pharmacology*; D058491:Bacterial Load / Q000187:drug effects / Q000276:immunology; D004195:Disease Models, Animal; D005260:Female; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D009169:Mycobacterium tuberculosis / Q000187:drug effects* / Q000276:immunology; D014376:Tuberculosis / Q000276:immunology / Q000517:prevention & control; D014611:Vaccination / Q000379:methods*; D019444:Vaccines, DNA / Q000494:pharmacology*
chemical_list: D000276:Adjuvants, Immunologic; D000942:Antigens, Bacterial; D001500:BCG Vaccine; D019444:Vaccines, DNA