title: Comprehensive Assessment of the Association between FCGRs polymorphisms and the risk of systemic lupus erythematosus: Evidence from a Meta-Analysis.
abstract: We performed a meta analysis to assess the relationship of FCGRs polymorphisms with the risk of SLE. Thirty-five articles (including up to 5741 cases and 6530 controls) were recruited for meta-analysis. The strongest association was observed between FCGR2B rs1050501 and SLE under the recessive genotypic model of C allele in the overall population (CC vs CT/TT, OR = 1.754, 95%CI: 1.422-2.165, P = 1.61 × 10(-7)) and in Asian population (CC vs CT/TT, OR = 1.784, 95%CI; 1.408-2.261, P = 1.67 × 10(-6)). We also found that FCGR3A rs396991 were significant association with the susceptibility to SLE in overall population in recessive model of T allele (TT vs TG/GG, OR = 1.263, 95%CI: 1.123-1.421, P = 9.62 × 10(-5)). The results also showed that significant association between FCGR2A rs1801274 and SLE under the allelic model in the overall population (OR = 0.879 per A allele, 95%CI: 0.819-0.943, P = 3.31 × 10(-4)). The meta-analysis indicated that FCGR3B copy number polymorphism NA1·NA2 was modestly associated with SLE in overall population (OR = 0.851 per NA1, 95%CI: 0.772-0.938, P = 1.2 × 10(-3)). We concluded that FCGR2B rs1050501 C allele and FCGR3A rs396991 T allele might contribute to susceptibility and development of SLE, and were under recessive association model. While, FCGR2A rs1801274 A allele and FCGR3B NA1 were associated with SLE and reduced the risk of SLE.
authors.affiliation: The Affiliated Hospital and Institute of Aging Research, School of Medicine, Hangzhou Normal University, Hangzhou, Zhejiang, China.
authors.forename: Xiao-Wei
authors.initials: XW
authors.lastname: Zhu
authors.affiliation: Department of Cardiovascular Medicine, the Second People's Hospital of Wuhu City, Wuhu, Anhui, China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Dermatology, The Affiliated Hospital of Binzhou Medical University, Binzhou, Shandong, China.
authors.forename: Yi-Hua
authors.initials: YH
authors.lastname: Wei
authors.affiliation: The Affiliated Hospital and Institute of Aging Research, School of Medicine, Hangzhou Normal University, Hangzhou, Zhejiang, China.
authors.forename: Pian-Pian
authors.initials: PP
authors.lastname: Zhao
authors.affiliation: The Affiliated Hospital and Institute of Aging Research, School of Medicine, Hangzhou Normal University, Hangzhou, Zhejiang, China.
authors.forename: Xiao-Bo
authors.initials: XB
authors.lastname: Wang
authors.affiliation: The Affiliated Hospital and Institute of Aging Research, School of Medicine, Hangzhou Normal University, Hangzhou, Zhejiang, China.
authors.forename: Jing-Jing
authors.initials: JJ
authors.lastname: Rong
authors.affiliation: The Affiliated Hospital and Institute of Aging Research, School of Medicine, Hangzhou Normal University, Hangzhou, Zhejiang, China.
authors.forename: Wen-Ying
authors.initials: WY
authors.lastname: Zhong
authors.affiliation: The Affiliated Hospital and Institute of Aging Research, School of Medicine, Hangzhou Normal University, Hangzhou, Zhejiang, China.
authors.forename: Xing-Wei
authors.initials: XW
authors.lastname: Zhang
authors.affiliation: The Affiliated Hospital and Institute of Aging Research, School of Medicine, Hangzhou Normal University, Hangzhou, Zhejiang, China.
authors.forename: Li
authors.initials: L
authors.lastname: Wang
authors.affiliation: The Affiliated Hospital and Institute of Aging Research, School of Medicine, Hangzhou Normal University, Hangzhou, Zhejiang, China.
authors.forename: Hou-Feng
authors.initials: HF
authors.lastname: Zheng
mesh_terms: D000483:Alleles; D005260:Female; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000235:genetics*; D008297:Male; D011110:Polymorphism, Genetic; D017452:Receptors, IgG / Q000235:genetics*; D012307:Risk Factors
chemical_list: C445323:FCGR2A protein, human; C499173:FCGR2B protein, human; C496124:FCGR3A protein, human; D017452:Receptors, IgG