title: Sobol Sensitivity Analysis: A Tool to Guide the Development and Evaluation of Systems Pharmacology Models.
abstract: A systems pharmacology model typically integrates pharmacokinetic, biochemical network, and systems biology concepts into a unifying approach. It typically consists of a large number of parameters and reaction species that are interlinked based upon the underlying (patho)physiology and the mechanism of drug action. The more complex these models are, the greater the challenge of reliably identifying and estimating respective model parameters. Global sensitivity analysis provides an innovative tool that can meet this challenge. CPT Pharmacometrics Syst. Pharmacol. (2015) 4, 69-79; doi:10.1002/psp4.6; published online 25 February 2015.
authors.affiliation: Department of Pharmaceutics, Center for Pharmacometrics and Systems Pharmacology, College of Pharmacy, University of Florida, Orlando, Florida, USA.
authors.forename: X-Y
authors.initials: XY
authors.lastname: Zhang
authors.affiliation: Department of Pharmaceutics, Center for Pharmacometrics and Systems Pharmacology, College of Pharmacy, University of Florida, Orlando, Florida, USA.
authors.forename: M N
authors.initials: MN
authors.lastname: Trame
authors.affiliation: Department of Pharmaceutics, Center for Pharmacometrics and Systems Pharmacology, College of Pharmacy, University of Florida, Orlando, Florida, USA.
authors.forename: L J
authors.initials: LJ
authors.lastname: Lesko
authors.affiliation: Department of Pharmaceutics, Center for Pharmacometrics and Systems Pharmacology, College of Pharmacy, University of Florida, Orlando, Florida, USA.
authors.forename: S
authors.initials: S
authors.lastname: Schmidt
mesh_terms: D000818:Animals; D006801:Humans; D008962:Models, Theoretical; D010599:Pharmacokinetics; D010600:Pharmacology; D015203:Reproducibility of Results; D049490:Systems Biology / Q000379:methods*; D018511:Systems Integration