title: Investigation of a Possible Role for the Histidine Decarboxylase Gene in Tourette Syndrome in the Chinese Han Population: A Family-Based Study.
abstract: Tourette syndrome (TS) is a polygenic neuropsychiatric disease. Previous studies have indicated that dysregulation in the histaminergic system may play a crucial role in disease onset. In this study, we investigated the role of the histidine decarboxylase gene (HDC) in TS susceptibility in the Chinese Han population. After genotyping 241 TS nuclear families trios, we analyzed three tag HDC single nucleotide polymorphisms (rs854150, rs854151, and rs854157) in a family-based study using the transmission disequilibrium test (TDT) and haplotype relative risk (HRR). TDT showed no over-transmission in these SNPs across the HDC region (for rs854150: χ2 = 0.472, P = 0.537, OR = 1.097, 95%CI = 0.738-1.630; for rs854151: χ2 = 0.043, P = 0.889, OR = 1.145, 95%CI = 0.767-1.709; for rs854157:χ2 = 0.984, P = 0.367, OR = 1.020, 95%CI = 0.508-2.049). HRR also showed the same tendency (for rs854150: χ2 = 0.211, P = 0.646, OR = 1.088, 95%CI = 0.759-1.559; for rs854151: χ2 = 0.134, P = 0.714, OR = 0.935, 95%CI = 0.653-1.339; for rs854157:χ2 = 0.841, P = 0.359, OR = 1.206, 95%CI = 0.808-1.799). Additionally, the haplotype-based haplotype relative risk showed a negative association. Although these findings indicate an unlikely association between HDC and TS in the Chinese Han population, a potential role for HDC cannot be ruled out in TS etiology. Future research should investigate this more thoroughly using different populations and larger samples.
authors.affiliation: Department of Anesthesiology, the Affiliated Hospital of Qingdao University, Qingdao, China.
authors.forename: He
authors.initials: H
authors.lastname: Dong
authors.affiliation: Prenatal diagnosis center, the Affiliated Hospital of Qingdao University, Qingdao, China.
authors.forename: Wenmiao
authors.initials: W
authors.lastname: Liu
authors.affiliation: Department of Cardiac Ultrasound, the Affiliated Hospital of Qingdao University, Qingdao, China.
authors.forename: Meixin
authors.initials: M
authors.lastname: Liu
authors.affiliation: Department of Clinical Laboratory, the Affiliated Hospital of Qingdao University, Qingdao, China.
authors.forename: Longqiang
authors.initials: L
authors.lastname: Xu
authors.affiliation: Department of Andrology, the Affiliated Hospital of Qingdao University, Qingdao, China.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Li
authors.affiliation: Prenatal diagnosis center, the Affiliated Hospital of Qingdao University, Qingdao, China.
authors.forename: Ru
authors.initials: R
authors.lastname: Zhang
authors.affiliation: Department of Respiratory Medicine, the Affiliated Hospital of Qingdao University, Qingdao, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Prenatal diagnosis center, the Affiliated Hospital of Qingdao University, Qingdao, China.|Genetic Laboratory, the Affiliated Hospital of Qingdao University, Qingdao, China.
authors.forename: Shiguo
authors.initials: S
authors.lastname: Liu
mesh_terms: D002648:Child; D002681:China / Q000208:ethnology; D005006:Ethnicity / Q000235:genetics*; D005260:Female; D060005:Genotyping Techniques; D006239:Haplotypes; D006640:Histidine Decarboxylase / Q000235:genetics*; D006801:Humans; D015810:Linkage Disequilibrium; D008297:Male; D010375:Pedigree; D020641:Polymorphism, Single Nucleotide; D005879:Tourette Syndrome / Q000201:enzymology* / Q000235:genetics*
chemical_list: D006640:Histidine Decarboxylase