title: Association of interleukin 1 gene cluster and interleukin 1 receptor gene polymorphisms with ischemic heart failure.
abstract: BACKGROUND
  Proinflammatory cytokines have been known to play a considerable part in the pathomechanisms of chronic heart failure (CHF). Given the importance of proinflammatory cytokines in the context of the failing heart, we assessed whether the polymorphisms of interleukin (IL)-1 gene cluster, including IL-1α, IL-1β, and IL-1 receptor antagonist (IL-1RA) and IL-1R gene are predictors of CHF due to ischemic heart disease.
  
  
  METHODS
  Forty- three patients with ischemic heart failure were recruited in this study as patients group and compared with 140 healthy unrelated control subjects. Using polymerase chain reaction with sequence-specific primers method, the allele and genotype frequency of 5 single nucleotide polymorphisms (SNPs) within the IL-1α (-889), IL-1β (-511, +3962), IL-1R (psti 1970), and IL-1RA (mspa1 11100) genes were determined.
  
  
  RESULTS
  The frequency of the IL-1β -511/C allele was significantly higher in the patient group compared to that in the control group (p = 0.031). The IL-1β (-511) C/C genotype was significantly overrepresented in patients compared to controls (p = 0.022).
  
  
  CONCLUSIONS
  Particular allele and genotype in IL-1β gene were overrepresented in patients with ischemic heart failure, possibly affecting the individual susceptibility to this disease (Tab. 1, Ref. 27).
authors.forename: M J
authors.initials: MJ
authors.lastname: Mahmoudi
authors.forename: M
authors.initials: M
authors.lastname: Taghvaei
authors.forename: S
authors.initials: S
authors.lastname: Harsini
authors.forename: A A
authors.initials: AA
authors.lastname: Amirzargar
authors.forename: M
authors.initials: M
authors.lastname: Hedayat
authors.forename: M
authors.initials: M
authors.lastname: Mahmoudi
authors.forename: E
authors.initials: E
authors.lastname: Nematipour
authors.forename: E
authors.initials: E
authors.lastname: Farhadi
authors.forename: N
authors.initials: N
authors.lastname: Esfahanian
authors.forename: M
authors.initials: M
authors.lastname: Sadr
authors.forename: K
authors.initials: K
authors.lastname: Nourijelyani
authors.forename: N
authors.initials: N
authors.lastname: Rezaei
mesh_terms: D000328:Adult; D000368:Aged; D000483:Alleles; D016022:Case-Control Studies; D017931:DNA Primers; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006333:Heart Failure / Q000175:diagnosis / Q000235:genetics*; D006801:Humans; D053590:Interleukin 1 Receptor Antagonist Protein / Q000235:genetics*; D007375:Interleukin-1 / Q000235:genetics*; D053582:Interleukin-1alpha / Q000235:genetics; D053583:Interleukin-1beta / Q000235:genetics; D008297:Male; D008875:Middle Aged; D005810:Multigene Family; D017202:Myocardial Ischemia / Q000175:diagnosis / Q000235:genetics*; D016133:Polymerase Chain Reaction; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D017472:Receptors, Interleukin-1 / Q000235:genetics*
chemical_list: D017931:DNA Primers; C508584:IL1A protein, human; D053590:Interleukin 1 Receptor Antagonist Protein; D007375:Interleukin-1; D053582:Interleukin-1alpha; D053583:Interleukin-1beta; D017472:Receptors, Interleukin-1
keywords: heart failure; interleukin-1.; single nucleotide polymorphism