title: Mechanisms of Melanoma Promotion by Ultraviolet Radiation.
abstract: The mutagenic properties of ultraviolet radiation drive the initiation of melanoma. Induction of matrix metalloproteinases in melanoma cells by longwave UVA radiation, possibly via a Warburg-like effect, promotes melanoma invasiveness. This is one of several mechanisms by which ultraviolet radiation also promotes further growth of previously established melanomas.
authors.affiliation: Department of Dermatology, Roger Williams Medical Center, Providence, Rhode Island, USA and Boston University School of Medicine, Boston, Massachusetts, USA. Electronic address: truenger@bu.edu.
authors.forename: Thomas M
authors.initials: TM
authors.lastname: Rünger
mesh_terms: D000818:Animals; D004249:DNA Damage / Q000528:radiation effects*; D018450:Disease Progression; D006801:Humans; D008545:Melanoma / Q000209:etiology* / Q000503:physiopathology; D009381:Neoplasms, Radiation-Induced / Q000473:pathology* / Q000503:physiopathology; D018570:Risk Assessment; D012680:Sensitivity and Specificity; D012878:Skin Neoplasms / Q000209:etiology* / Q000503:physiopathology; D014407:Tumor Cells, Cultured / Q000528:radiation effects; D014466:Ultraviolet Rays / Q000009:adverse effects*; D000096142:Cutaneous Malignant Melanoma