title: Comparison of Two Algorithms for Analysis of Perfusion Computed Tomography Data for Evaluation of Cerebral Microcirculation in Chronic Subdural Hematoma.
abstract: The aim of this work was comparison of two algorithms of perfusion computed tomography (PCT) data analysis for evaluation of cerebral microcirculation in the perifocal zone of chronic subdural hematoma (CSDH). Twenty patients with CSDH after polytrauma were included in the study. The same PCT data were assessed quantitatively in cortical brain region beneath the CSDH (zone 1), and in the corresponding contralateral brain hemisphere (zone 2) without and with the use of perfusion calculation mode excluding vascular pixel 'Remote Vessels' (RV); 1st and 2nd analysis method, respectively. Comparison with normal values for perfusion indices in the zone 1 in the 1st analysis method showed a significant (p < 0.01) increase in CBV and CBF, and no significant increase in MTT and TTP. Use of the RV mode (2nd analysis method) showed no statistically reliable change of perfusion parameters in the microcirculatory blood flow of the 2nd zone. Maintenance of microcirculatory blood flow perfusion reflects the preservation of cerebral blood flow autoregulation in patients with CSDH.
authors.affiliation: Department of Neurosurgery, Nizhniy Novgorod State Medical Academy, 10/1, Minin Str., Nizhniy Novgorod, 603950, Russia. xtro7@mail.ru.|Department of Neurosurgery, University of New Mexico School of Medicine, University of New Mexico, 1, MSC 10 5615, Albuquerque, NM, 87131, USA. xtro7@mail.ru.|Department of Polytrauma and Critical Care, Regional Hospital named after N.A. Semashko, 190, Rodionov str., Nizhny Novgorod, 603126, Russian Federation. xtro7@mail.ru.
authors.forename: Alexey O
authors.initials: AO
authors.lastname: Trofimov
authors.affiliation: Department of Neurosurgery, Nizhniy Novgorod State Medical Academy, 10/1, Minin Str., Nizhniy Novgorod, 603950, Russia.|Department of Neurosurgery, University of New Mexico School of Medicine, University of New Mexico, 1, MSC 10 5615, Albuquerque, NM, 87131, USA.
authors.forename: George
authors.initials: G
authors.lastname: Kalentiev
authors.affiliation: Department of Neurosurgery, Nizhniy Novgorod State Medical Academy, 10/1, Minin Str., Nizhniy Novgorod, 603950, Russia.|Department of Neurosurgery, University of New Mexico School of Medicine, University of New Mexico, 1, MSC 10 5615, Albuquerque, NM, 87131, USA.
authors.forename: Oleg
authors.initials: O
authors.lastname: Voennov
authors.affiliation: Department of Neurosurgery, Nizhniy Novgorod State Medical Academy, 10/1, Minin Str., Nizhniy Novgorod, 603950, Russia.|Department of Neurosurgery, University of New Mexico School of Medicine, University of New Mexico, 1, MSC 10 5615, Albuquerque, NM, 87131, USA.
authors.forename: Michail
authors.initials: M
authors.lastname: Yuriev
authors.affiliation: Department of Neurosurgery, Nizhniy Novgorod State Medical Academy, 10/1, Minin Str., Nizhniy Novgorod, 603950, Russia.|Department of Neurosurgery, University of New Mexico School of Medicine, University of New Mexico, 1, MSC 10 5615, Albuquerque, NM, 87131, USA.
authors.forename: Darya
authors.initials: D
authors.lastname: Agarkova
authors.affiliation: Department of Neurosurgery, Nizhniy Novgorod State Medical Academy, 10/1, Minin Str., Nizhniy Novgorod, 603950, Russia.|Department of Neurosurgery, University of New Mexico School of Medicine, University of New Mexico, 1, MSC 10 5615, Albuquerque, NM, 87131, USA.
authors.forename: Svetlana
authors.initials: S
authors.lastname: Trofimova
authors.affiliation: Department of Neurosurgery, Nizhniy Novgorod State Medical Academy, 10/1, Minin Str., Nizhniy Novgorod, 603950, Russia.|Department of Neurosurgery, University of New Mexico School of Medicine, University of New Mexico, 1, MSC 10 5615, Albuquerque, NM, 87131, USA.
authors.forename: Denis E
authors.initials: DE
authors.lastname: Bragin
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000465:Algorithms; D002560:Cerebrovascular Circulation; D002908:Chronic Disease; D005260:Female; D006408:Hematoma, Subdural / Q000000981:diagnostic imaging* / Q000503:physiopathology; D006706:Homeostasis; D006801:Humans; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D008297:Male; D008833:Microcirculation; D008875:Middle Aged; D061330:Multidetector Computed Tomography; D055420:Perfusion Imaging / Q000379:methods*; D011237:Predictive Value of Tests; D011446:Prospective Studies; D015203:Reproducibility of Results; D055815:Young Adult
keywords: Cerebral microvasculature; Chronic subdural hematoma; Perfusion computerized tomography; Perifocal zone