title: S100A12 is up-regulated in pulmonary tuberculosis and predicts the extent of alveolar infiltration on chest radiography: an observational study.
abstract: Pulmonary tuberculosis (PTB) results in lung functional impairment and there are no surrogate markers to monitor the extent of lung involvement. We investigated the clinical significance of S100A12 and soluble receptor for advanced glycation end-products (sRAGE) for predicting the extent of lung involvement. We performed an observational study in India with 119 newly diagnosed, treatment naïve, sputum smear positive, HIV-negative PTB patients and 163 healthy controls. All patients were followed-up for six months. Sociodemographic variables and the serum levels of S100A12, sRAGE, esRAGE, HMGB-1, TNF-α, IFN-γ and CRP were measured. Lung involvement in PTB patients was assessed by chest radiography. Compared with healthy controls, PTB patients had increased serum concentrations of S100A12 while sRAGE was decreased. S100A12 was an independent predictor of disease occurrence (OR 1.873, 95%CI 1.212-2.891, p = 0.004). Under DOTS therapy, S100A12 decreased significantly after 4 months whereas CRP significantly decreased after 2 months (p < 0.0001). Importantly, although CRP was also an independent predictor of disease occurrence, only S100A12 was a significant predictor of lung alveolar infiltration (OR 2.60, 95%CI 1.35-5.00, p = 0.004). These results suggest that S100A12 has the potential to assess the extent of alveolar infiltration in PTB.
authors.affiliation: Institute for Microbiology and Hygiene, Charité-Universitätsmedizin Berlin, Berlin, Germany.|Septomics Research Center, Jena University Hospital, Jena, Germany.
authors.forename: Luis C
authors.initials: LC
authors.lastname: Berrocal-Almanza
authors.affiliation: Institute for Microbiology and Hygiene, Charité-Universitätsmedizin Berlin, Berlin, Germany.
authors.forename: Surabhi
authors.initials: S
authors.lastname: Goyal
authors.affiliation: Department of Immunology, Bhagwan Mahavir Medical Research Centre, Hyderabad, India.
authors.forename: Abid
authors.initials: A
authors.lastname: Hussain
authors.affiliation: Septomics Research Center, Jena University Hospital, Jena, Germany.
authors.forename: Tilman E
authors.initials: TE
authors.lastname: Klassert
authors.affiliation: BioControl Jena GmbH, Jena, Germany.
authors.forename: Dominik
authors.initials: D
authors.lastname: Driesch
authors.affiliation: Department of Radiology, Campus Benjamin Franklin, Charité - Universitätsmedizin Berlin, Germany.
authors.forename: Zarko
authors.initials: Z
authors.lastname: Grozdanovic
authors.affiliation: Department of Immunology, Bhagwan Mahavir Medical Research Centre, Hyderabad, India.
authors.forename: Gadamm
authors.initials: G
authors.lastname: Sumanlatha
authors.affiliation: Pathogen Biology Laboratory, Department of Biotechnology and Bioinformatics, University of Hyderabad, Hyderabad, India.
authors.forename: Niyaz
authors.initials: N
authors.lastname: Ahmed
authors.affiliation: Immunology and Molecular Biology, LEPRA Society- Blue Peter Research Centre, Hyderabad, India.
authors.forename: Vijayalakshmi
authors.initials: V
authors.lastname: Valluri
authors.affiliation: Institute for Microbiology and Hygiene, Charité-Universitätsmedizin Berlin, Berlin, Germany.
authors.forename: Melanie L
authors.initials: ML
authors.lastname: Conrad
authors.affiliation: Institute for Microbiology and Hygiene, Charité-Universitätsmedizin Berlin, Berlin, Germany.
authors.forename: Nickel
authors.initials: N
authors.lastname: Dittrich
authors.affiliation: Institute for Microbiology and Hygiene, Charité-Universitätsmedizin Berlin, Berlin, Germany.
authors.forename: Ralf R
authors.initials: RR
authors.lastname: Schumann
authors.affiliation: Department of Paediatric Radiology, Campus Virchow-Klinikum, Charité - Universitätsmedizin Berlin, Germany.
authors.forename: Birgit
authors.initials: B
authors.lastname: Lala
authors.affiliation: Septomics Research Center, Jena University Hospital, Jena, Germany.
authors.forename: Hortense
authors.initials: H
authors.lastname: Slevogt
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D008297:Male; D000951:Antigens, Neoplasm / Q000097:blood; D016207:Cytokines / Q000097:blood; D024243:HMGB1 Protein / Q000097:blood; D020928:Mitogen-Activated Protein Kinases / Q000097:blood; D011650:Pulmonary Alveoli / Q000000981:diagnostic imaging / Q000378:metabolism; D011655:Pulmonary Embolism / Q000097:blood / Q000000981:diagnostic imaging; D000067616:S100A12 Protein / Q000097:blood; D014057:Tomography, X-Ray Computed; D015854:Up-Regulation
chemical_list: D000951:Antigens, Neoplasm; D016207:Cytokines; D024243:HMGB1 Protein; C585491:HMGB1 protein, human; D020928:Mitogen-Activated Protein Kinases; C498978:MOK protein, human; D000067616:S100A12 Protein; C090441:S100A12 protein, human