title: Selective Synthesis of N-Unsubstituted and N-Arylindoles by the Reaction of Arynes with Azirines.
abstract: The transition-metal-free and temperature-dependent highly selective reaction of arynes with 2H-azirines allowing the synthesis of either N-unsubstituted or N-arylindoles has been developed. At 60 °C, arynes generated from 2-(trimethylsilyl)aryl triflates smoothly insert into 2H-azirines to form 2,3-diarylindoles with high selectivity. Interestingly, when the reaction was performed at -10 °C, the selectivity was switched to the formation of 1,2,3-triarylindoles in good yields.
authors.affiliation: Academy of Scientific and Innovative Research (AcSIR) , New Delhi 110020, India.
authors.forename: Manikandan
authors.initials: M
authors.lastname: Thangaraj
authors.affiliation: Academy of Scientific and Innovative Research (AcSIR) , New Delhi 110020, India.
authors.forename: Sachin Suresh
authors.initials: SS
authors.lastname: Bhojgude
authors.forename: Shailja
authors.initials: S
authors.lastname: Jain
authors.forename: Rajesh G
authors.initials: RG
authors.lastname: Gonnade
authors.affiliation: Academy of Scientific and Innovative Research (AcSIR) , New Delhi 110020, India.
authors.forename: Akkattu T
authors.initials: AT
authors.lastname: Biju