title: Dual pH/Activity Probes Expand the Cathepsin Toolkit.
abstract: In a recent issue of Cell Chemical Biology, Sanman et al. (2016) describe novel activity-based probes that simultaneously report cathepsin activity and pH. Using these bifunctional probes, the authors find that the intracellular bacterial pathogen Salmonella typhimurium induces dynamic alterations in the pH of cathepsin-containing organelles in both infected and bystander cells.
authors.affiliation: Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address: sunshin@mail.med.upenn.edu.
authors.forename: Sunny
authors.initials: S
authors.lastname: Shin
mesh_terms: D001424:Bacterial Infections; D002403:Cathepsins; D011992:Endosomes; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008247:Lysosomes
chemical_list: D002403:Cathepsins