title: The Expanding Clinical Spectrum of Genetic Pediatric Epileptic Encephalopathies.
abstract: Pediatric epileptic encephalopathies represent a clinically challenging and often devastating group of disorders that affect children at different stages of infancy and childhood. With the advances in genetic testing and neuroimaging, the etiologies of these epileptic syndromes are now better defined. The various encephalopathies that are reviewed in this article include the following: early infantile epileptic encephalopathy or Ohtahara syndrome, early myoclonic encephalopathy, epilepsy of infancy with migrating focal seizures, West syndrome, severe myoclonic epilepsy in infancy (Dravet syndrome), Landau-Kleffner syndrome, Lennox-Gastaut syndrome, and epileptic encephalopathy with continuous spike-and-wave during sleep. Their clinical features, prognosis as well as underlying genetic etiologies are presented and updated.
authors.affiliation: Department of Pediatrics and Adolescent Medicine, American University of Beirut, Lebanon.
authors.forename: Rolla
authors.initials: R
authors.lastname: Shbarou
authors.affiliation: Division of Pediatric Neurology, Children's Health Center, Duke University Medical Center, Durham, NC. Electronic address: mohamad.mikati@duke.edu.
authors.forename: Mohamad A
authors.initials: MA
authors.lastname: Mikati
mesh_terms: D004831:Epilepsies, Myoclonic / Q000209:etiology / Q000235:genetics / Q000503:physiopathology; D006801:Humans; D007223:Infant; D018887:Landau-Kleffner Syndrome / Q000209:etiology / Q000235:genetics / Q000503:physiopathology; D065768:Lennox Gastaut Syndrome / Q000209:etiology / Q000235:genetics / Q000503:physiopathology; D013036:Spasms, Infantile / Q000209:etiology / Q000235:genetics / Q000503:physiopathology