title: [Development of Regulatory T Cells Mediated by NF-κB and Its Role in GVHD -Review].
abstract: Graft versus host disease (GVHD) is the major complication of allogenic hematopoietic stem cell transplantation (allo-HSCT), and is a mainly responsible result for the non-recurrence-related mortality of long-term survived patient after transplantation. Studies indicated that regulatory T (Treg) cells can inhibit early-GVHD. Since the transcriptional factor NF-κB has been implicated in the regulation of Treg cell proliferation and activation, it becomes a potential target of GVHD therapy. Thus, in this review the function and signaling pathway of NF-κB, as well as the relationship between GVHD and NF-κB, are discussed and summarized.
authors.affiliation: Department of Hematology, Center of Hematologic Diseases of Chinese PLA; Lanzhou Military Command General Hospital, Lanzhou 730050, Gansu Province, China.
authors.forename: Hai-Ying
authors.initials: HY
authors.lastname: Zhang
authors.affiliation: Department of Hematology, Center of Hematologic Diseases of Chinese PLA; Lanzhou Military Command General Hospital, Lanzhou 730050, Gansu Province, China.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Zhao
authors.affiliation: Department of Hematology, Center of Hematologic Diseases of Chinese PLA; Lanzhou Military Command General Hospital, Lanzhou 730050, Gansu Province, China.E-mail: wutaozhen@yeah.net.
authors.forename: Tao
authors.initials: T
authors.lastname: Wu
mesh_terms: D006086:Graft vs Host Disease; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D016328:NF-kappa B; D050378:T-Lymphocytes, Regulatory
chemical_list: D016328:NF-kappa B