title: Potential drug-drug interaction in Mexican patients with schizophrenia.
abstract: OBJECTIVE
  The aim of this study was to observe potential drug-drug interactions in the medication of Mexican schizophrenic patients.
  
  
  METHODS
  We performed a retrospective and cross-sectional study that was carried out in a psychiatric clinic. Only the prescriptions of patients with schizophrenia whose diagnoses were based on the DSM-IV instrument were included in this study. The Drug Interactions Checker software ( http://www.drugs.com/drug_interactions.html ) was used in this study to analyse potential drug-drug interactions.
  
  
  RESULTS
  In total, 86 of 126 patients were at risk of potential drug-drug interactions. Haloperidol and biperiden was the most common drug pair of 232 pairs evaluated. In our study, 13.8% of drug-drug interaction showed a major level of severity, whereas in 83.2%, the interaction was moderate. Finally, central nervous system (CNS) depression and anticholinergic effect were the main possible effects of drug-drug interaction.
  
  
  CONCLUSIONS
  Our results revealed a high number of patients with schizophrenia receiving two or more drugs. The potential drug-drug interactions observed in the Mexican population are consistent with the concomitant use of antipsychotics, benzodiazepines, and antidepressants prescribed in schizophrenia that could cause central nervous system (CNS) depression and anticholinergic effect. Drug-drug interaction must be considered when the patient with schizophrenia is medicated.
authors.affiliation: a División Académica de Ciencias de la Salud , Universidad Juárez Autónoma de Tabasco , Villahermosa , Tabasco , México ;
authors.forename: María Conchita
authors.initials: MC
authors.lastname: Ocaña-Zurita
authors.affiliation: a División Académica de Ciencias de la Salud , Universidad Juárez Autónoma de Tabasco , Villahermosa , Tabasco , México ;
authors.forename: Isela E
authors.initials: IE
authors.lastname: Juárez-Rojop
authors.affiliation: b Instituto Nacional de Medicina Genómica (INMEGEN), Servicios de Atención Psiquiátrica (SAP), Secretaría de Salud , México , D. F , México ;
authors.forename: Alma
authors.initials: A
authors.lastname: Genis
authors.affiliation: a División Académica de Ciencias de la Salud , Universidad Juárez Autónoma de Tabasco , Villahermosa , Tabasco , México ;
authors.forename: Carlos Alfonso
authors.initials: CA
authors.lastname: Tovilla-Zárate
authors.affiliation: a División Académica de Ciencias de la Salud , Universidad Juárez Autónoma de Tabasco , Villahermosa , Tabasco , México ;
authors.forename: Thelma Beatriz
authors.initials: TB
authors.lastname: González-Castro
authors.affiliation: c Hospital General de Yajalón, Secretaría de Salud , Yajalón , Chiapas , México.
authors.forename: María
authors.initials: M
authors.lastname: Lilia López-Narváez
authors.affiliation: a División Académica de Ciencias de la Salud , Universidad Juárez Autónoma de Tabasco , Villahermosa , Tabasco , México ;
authors.forename: María Elena
authors.initials: ME
authors.lastname: de la O de la O
authors.affiliation: b Instituto Nacional de Medicina Genómica (INMEGEN), Servicios de Atención Psiquiátrica (SAP), Secretaría de Salud , México , D. F , México ;
authors.forename: Humberto
authors.initials: H
authors.lastname: Nicolini
mesh_terms: D000293:Adolescent; D000328:Adult; D014150:Antipsychotic Agents / Q000009:adverse effects / Q000627:therapeutic use*; D001712:Biperiden / Q000009:adverse effects / Q000627:therapeutic use; D003430:Cross-Sectional Studies; D004344:Drug Incompatibility; D004347:Drug Interactions; D005260:Female; D006220:Haloperidol / Q000009:adverse effects / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008800:Mexico / Q000453:epidemiology; D008875:Middle Aged; D018727:Muscarinic Antagonists / Q000009:adverse effects / Q000627:therapeutic use*; D012189:Retrospective Studies; D012559:Schizophrenia / Q000188:drug therapy* / Q000453:epidemiology; D055815:Young Adult
chemical_list: D014150:Antipsychotic Agents; D018727:Muscarinic Antagonists; D001712:Biperiden; D006220:Haloperidol
keywords: Drug–drug interaction; Mexican population; schizophrenia