title: Toll-tally tubular: A newly identified Toll-like receptor-FoxO pathway regulates dynamics of the neuronal microtubule network.
abstract: Recent studies reveal a conserved role for FoxO transcription factors in establishing neuronal structure and circuit function. In this issue, McLaughlin et al. (2016. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201601014) identify a novel Toll-like receptor-FoxO pathway that represses the mitotic kinesin Pavarotti/MKLP1 to promote dynamic microtubules required for axonal transport and activity-dependent remodeling of presynaptic terminals.
authors.affiliation: Laboratory of Genetics, University of Wisconsin-Madison, Madison, WI 53706 oconnorgiles@wisc.edu.
authors.forename: Kate
authors.initials: K
authors.lastname: O'Connor-Giles
mesh_terms: D000818:Animals; D051858:Forkhead Transcription Factors / Q000378:metabolism*; D006801:Humans; D008870:Microtubules / Q000378:metabolism*; D008954:Models, Biological; D009474:Neurons / Q000378:metabolism*; D015398:Signal Transduction; D051193:Toll-Like Receptors / Q000378:metabolism*
chemical_list: D051858:Forkhead Transcription Factors; D051193:Toll-Like Receptors