title: Risk of Central Nervous System Tumors in Children Related to Parental Occupational Pesticide Exposures in three European Case-Control Studies.
abstract: The aim of this study was to assess the risk of childhood central nervous system (CNS) tumors associated with parental occupational pesticide exposure.
  
  
  
  We pooled three population-based case-control studies from France, Germany, and the United Kingdom. Cases were children below 15 years of age with CNS tumors; controls were matched by gender and age. A general population job-exposure matrix assessed parental occupational pesticide exposure. Logistic regressions estimated odds ratios (ORs) and 95% confidence intervals (CIs).
  
  
  
  The study included 1361 cases and 5498 controls. Prevalence of maternal occupational pesticide exposure during pregnancy was low and no association with childhood CNS tumors was detected (OR 0.76, 95% CI: 0.41 to 1.41). Around conception, OR for childhood CNS tumors associated with paternal occupational pesticide exposure was 0.71 (95% CI: 0.53 to 0.95).
  
  
  
  Our results do not suggest a role of parental occupational pesticide exposure in the etiology of childhood CNS tumors.
authors.affiliation: International Agency for Research on Cancer (IARC), Section of Environment and Radiation, Lyon (Febvey, Drs Schüz, Bailey, Olsson); Institut National de la Santé (INSERM) U1153, Epidemiology and Biostatistics Sorbonne Paris Cité Center (CRESS), Epidemiology of Childhood and Adolescent Cancers Team (EPICEA), Villejuif (Drs Bailey, Clavel, Lacour, Orsi); Paris-Descartes University, UMRS-1153, Epidemiology and Biostatistics Sorbonne Paris Cité Center (CRESS) (Drs Bailey, Clavel, Lacour, Orsi); RNCE - National Registry of Childhood Cancers, Villejuif (Dr Clavel); RNCE - National Registry of Childhood Cancers, Nancy, France (Dr Lacour); Epidemiology and Cancer Statistics Group, Department of Health Sciences, University of York, UK (Drs Lightfoot, Roman); Institute for Risk Assessment Sciences (IRAS), Department of Environmental Epidemiology, Utrecht University (Drs Vermeulen, Kromhout); Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, The Netherlands (Dr Vermeulen); and The Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden (Dr Olsson).
authors.forename: Olivia
authors.initials: O
authors.lastname: Febvey
authors.forename: Joachim
authors.initials: J
authors.lastname: Schüz
authors.forename: Helen D
authors.initials: HD
authors.lastname: Bailey
authors.forename: Jacqueline
authors.initials: J
authors.lastname: Clavel
authors.forename: Brigitte
authors.initials: B
authors.lastname: Lacour
authors.forename: Laurent
authors.initials: L
authors.lastname: Orsi
authors.forename: Tracy
authors.initials: T
authors.lastname: Lightfoot
authors.forename: Eve
authors.initials: E
authors.lastname: Roman
authors.forename: Roel
authors.initials: R
authors.lastname: Vermeulen
authors.forename: Hans
authors.initials: H
authors.lastname: Kromhout
authors.forename: Ann
authors.initials: A
authors.lastname: Olsson
mesh_terms: D016022:Case-Control Studies; D016543:Central Nervous System Neoplasms / Q000453:epidemiology*; D002648:Child; D002675:Child, Preschool; D005260:Female; D005602:France; D005858:Germany; D006801:Humans; D008297:Male; D016273:Occupational Exposure / Q000009:adverse effects*; D010290:Parents; D010575:Pesticides / Q000009:adverse effects*; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000453:epidemiology*; D012307:Risk Factors; D006113:United Kingdom
chemical_list: D010575:Pesticides