title: New Cytotoxic Bibenzyl and Other Constituents from Bauhinia ungulata L. (Fabaceae).
abstract: A new bibenzyl, 2'-hydroxy-3,5-dimethoxy-4-methylbibenzyl (1) and four known compounds identified as 2'-hydroxy-3,5-dimethoxybibenzyl (2), liquiritigenin (3), guibourtinidol (4) and fisetinidol (5) were isolated from the roots of Bauhinia ungulata L. Phytochemical investigations of the stems of B. ungulata led to the isolation of the known compounds identified as liquiritigenin (3), guibourtinidol (4), fisetinidol (5), taraxerol (6), betulinic acid (7), taraxerone (8), glutinol (9), a mixture of sitosterol (10) and stigmasterol (11), pacharin (12), naringenin (13) and eriodictyol (14). The structures of these compounds were elucidated on the basis of their spectral data (IR, MS, 1D- and 2D-NMR). The cytotoxicity of the bibenzyl 1 has been evaluated against four human cancer cell lines, showing the IC50values of 4.3 and 6.5 μg ml-1against pro-myelocytic leukemia (HL-60) and cervical adenocarcinoma (HEP-2) cell lines, respectively. This article also registers for the first time the13C-NMR data of the known bibenzyl 2.
authors.affiliation: Departamento de Química Orgânica e Inorgânica, Centro de Ciências, Universidade Federal do Ceará, CP 12.200, 60021-940, Fortaleza, CE, Brazil.
authors.forename: Leôncio M
authors.initials: LM
authors.lastname: de Sousa
authors.affiliation: Departamento de Química Orgânica e Inorgânica, Centro de Ciências, Universidade Federal do Ceará, CP 12.200, 60021-940, Fortaleza, CE, Brazil.
authors.forename: Jarbas L
authors.initials: JL
authors.lastname: de Carvalho
authors.affiliation: Departamento de Química Orgânica e Inorgânica, Centro de Ciências, Universidade Federal do Ceará, CP 12.200, 60021-940, Fortaleza, CE, Brazil.
authors.forename: Horlando C
authors.initials: HC
authors.lastname: da Silva
authors.affiliation: Departamento de Química Orgânica e Inorgânica, Centro de Ciências, Universidade Federal do Ceará, CP 12.200, 60021-940, Fortaleza, CE, Brazil.
authors.forename: Telma L G
authors.initials: TL
authors.lastname: Lemos
authors.affiliation: Departamento de Química Orgânica e Inorgânica, Centro de Ciências, Universidade Federal do Ceará, CP 12.200, 60021-940, Fortaleza, CE, Brazil.
authors.forename: Angela M C
authors.initials: AM
authors.lastname: Arriaga
authors.affiliation: Laboratório de Ciências Químicas, CCT - Universidade Estadual do Norte Fluminense Darcy Ribeiro, 28013-602, Rio de Janeiro, RJ, Brazil.|Departamento de Química, ICE - Universidade Federal Rural do Rio de Janeiro, 28013-602, Rio de Janeiro, RJ, Brazil.
authors.forename: Raimundo
authors.initials: R
authors.lastname: Braz-Filho
authors.affiliation: Departamento de Fisiologia e Farmacologia, Centro de Ciências Biológicas, Universidade Federal de Pernambuco, Rua Professor Morais Rego 1235, 50670-901, Recife, PE, Brazil.
authors.forename: Gardênia C G
authors.initials: GC
authors.lastname: Militão
authors.affiliation: Departamento de Fisiologia e Farmacologia, Centro de Ciências Biológicas, Universidade Federal de Pernambuco, Rua Professor Morais Rego 1235, 50670-901, Recife, PE, Brazil.
authors.forename: Thiago D S
authors.initials: TD
authors.lastname: Silva
authors.affiliation: Embrapa Agroindústria Tropical, Rua Dra. Sara Mesquita, Planalto Pici, 60511-110, Fortaleza, CE, Brazil.
authors.forename: Paulo R V
authors.initials: PR
authors.lastname: Ribeiro
authors.affiliation: Departamento de Farmácia, Faculdade de Farmácia, Odontologia e Enfermagem, Universidade Federal do Ceará, Rua Capitão Francisco Pedro 1210, 60451-970, Fortaleza, CE, Brazil.
authors.forename: Gilvandete M P
authors.initials: GM
authors.lastname: Santiago
mesh_terms: D001593:Benzyl Compounds / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D007887:Fabaceae / Q000737:chemistry*; D006801:Humans; D015394:Molecular Structure; D013329:Structure-Activity Relationship
chemical_list: D001593:Benzyl Compounds
keywords: 
  Bauhinia ungulata
  ; Bibenzyls; Cytotoxic activities; Flavonoids; Triterpenoids