title: Pregnancy shortly after an acute episode of severe acquired thrombotic thrombocytopenic purpura.
abstract: Thrombotic thrombocytopenic purpura (TTP) is a rare but potentially fatal condition. In women with a previous history of TTP there is increased risk of recurrence during pregnancy and the puerperium. There is some evidence that the risk of relapse during pregnancy is increased if the interval between the event and conception is short. We present a case in which pregnancy was achieved a few days after full recovery from an acute episode of severe acquired TTP (ADAMTS13 activity <0.1%) which was successfully treated with four courses of plasma exchange. There was no relapse of TTP during pregnancy and a healthy baby was delivered at term; the puerperium was uneventful.
authors.affiliation: Filantropia Clinical Hospital, Bucharest, Romania. Electronic address: panaitescu.anca@yahoo.com.
authors.forename: Anca M
authors.initials: AM
authors.lastname: Panaitescu
authors.affiliation: Fundeni Clinical Institute, Bucharest, Romania.
authors.forename: Razvan
authors.initials: R
authors.lastname: Stoia
authors.affiliation: Filantropia Clinical Hospital, Bucharest, Romania.
authors.forename: Anca M
authors.initials: AM
authors.lastname: Ciobanu
authors.affiliation: Filantropia Clinical Hospital, Bucharest, Romania.
authors.forename: Mihaela
authors.initials: M
authors.lastname: Demetrian
authors.affiliation: Filantropia Clinical Hospital, Bucharest, Romania.
authors.forename: Gheorghe
authors.initials: G
authors.lastname: Peltecu
mesh_terms: D000208:Acute Disease; D000328:Adult; D005260:Female; D006801:Humans; D010951:Plasma Exchange; D010976:Platelet Count; D011247:Pregnancy; D011697:Purpura, Thrombotic Thrombocytopenic / Q000097:blood / Q000473:pathology* / Q000628:therapy
keywords: ADAMTS13; Plasma exchange; Pregnancy; Thrombotic thrombocytopenic purpura