title: The effect of dietary intake of coenzyme Q10 on skin parameters and condition: Results of a randomised, placebo-controlled, double-blind study.
abstract: Coenzyme Q10 (CoQ10) is a natural constituent of foods and is also often used in both functional foods and supplements. In addition, it is a common ingredient of cosmetics where it is believed to reduce the signs of skin ageing. However, the existing data about the effect of dietary intake of CoQ10 on skin parameters and condition are scarce. To gain an insight into this issue, we conducted a double-blind, placebo-controlled experiment with 33 healthy subjects. Our objective was to investigate the effects of 12 weeks of daily supplementation with 50 and 150 mg of CoQ10 on skin parameters and condition. Study was conducted with a water-soluble form of CoQ10 with superior bioavailability (Q10Vital®). While the results of some previous in vitro studies showed possible protection in UVB response, we did not observe significant changes in the minimal erythema dose (MED). On the other hand, the intake of CoQ10 limited seasonal deterioration of viscoelasticity and reduced some visible signs of ageing. We determined significantly reduced wrinkles and microrelief lines, and improved skin smoothness. Supplementation with CoQ10 did not significantly affect skin hydration and dermis thickness. © 2016 BioFactors, 43(1):132-140, 2017.
authors.affiliation: VIST-Higher School of Applied Sciences, Institute of Cosmetics, Ljubljana, Slovenia.|Nutrition Institute, Ljubljana, Slovenia.
authors.forename: Katja
authors.identifier: http://orcid.org/0000-0002-0032-318X
authors.initials: K
authors.lastname: Žmitek
authors.affiliation: VIST-Higher School of Applied Sciences, Institute of Cosmetics, Ljubljana, Slovenia.
authors.forename: Tina
authors.initials: T
authors.lastname: Pogačnik
authors.affiliation: Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia.
authors.forename: Liljana
authors.initials: L
authors.lastname: Mervic
authors.affiliation: VIST-Higher School of Applied Sciences, Institute of Cosmetics, Ljubljana, Slovenia.
authors.forename: Janko
authors.initials: J
authors.lastname: Žmitek
authors.affiliation: Nutrition Institute, Ljubljana, Slovenia.
authors.forename: Igor
authors.initials: I
authors.lastname: Pravst
mesh_terms: D000375:Aging / Q000187:drug effects*; D019587:Dietary Supplements; D004311:Double-Blind Method; D004548:Elasticity; D005260:Female; D006801:Humans; D008875:Middle Aged; D012867:Skin / Q000000981:diagnostic imaging / Q000187:drug effects*; D015595:Skin Aging / Q000187:drug effects*; D014451:Ubiquinone / Q000008:administration & dosage / Q000031:analogs & derivatives*
chemical_list: D014451:Ubiquinone; C024989:coenzyme Q10
keywords: CoQ10; Coenzyme Q10; anti-ageing; antioxidant; skin health