title: Obesity Cardiomyopathy: Pathophysiologic Factors and Nosologic Reevaluation.
abstract: Cardiovascular disease in populations with obesity is a major concern because of its epidemic proportion. Obesity leads to the development of cardiomyopathy directly via inflammatory mediators and indirectly by obesity-induced hypertension, diabetes and coronary artery diseases. The aim of this review article is to re-visit the available knowledge and the evidence on pathophysiologic mechanisms of obesity-related cardiomyopathy and to propose its placement into a specific category of myocardial disease.
authors.affiliation: Department of Internal Medicine, East Tennessee State University, Johnson City, Tennessee.
authors.forename: Samit
authors.initials: S
authors.lastname: Bhatheja
authors.affiliation: Department of Internal Medicine, East Tennessee State University, Johnson City, Tennessee.
authors.forename: Hemang B
authors.initials: HB
authors.lastname: Panchal
authors.affiliation: Section of Cardiomyopathy and Heart Transplantation, Heart and Vascular Institute, Ochsner Clinic, Jefferson, Louisiana.
authors.forename: Hector
authors.initials: H
authors.lastname: Ventura
authors.affiliation: Department of Internal Medicine, East Tennessee State University, Johnson City, Tennessee. Electronic address: pault@etsu.edu.
authors.forename: Timir K
authors.initials: TK
authors.lastname: Paul
mesh_terms: D000818:Animals; D009202:Cardiomyopathies / Q000097:blood / Q000453:epidemiology* / Q000503:physiopathology*; D006333:Heart Failure / Q000097:blood / Q000453:epidemiology* / Q000503:physiopathology*; D006801:Humans; D007333:Insulin Resistance / Q000502:physiology; D009765:Obesity / Q000097:blood / Q000453:epidemiology* / Q000503:physiopathology*
keywords: Heart failure; Metainflammation; Obesity cardiomyopathy; Obesity paradox