title: [Influence of Leukodeplated Blood Transfusion on Cellular Immunity of Acute Leukemia Patients].
abstract: OBJECTIVE
  To study the influence of leukodeplated blood transfusion on cellular immunity of patients with acute leuemia, so as to provide support for application of leuko-deplated blood transfusion in clinic.
  
  
  METHODS
  A total of 100 AL patients from January 2012 to December 2015 were chosen, and were divided into 2 groups: leukodeplated blood transfusion group(50 cases) and routine blood transfusion group(RBT) as control (50 cases). The effective rate, side effects, peripheral blood T cells and expression level of TLR2 and TLR4 were compared between 2 groups.
  
  
  RESULTS
  The expression levels CD3(+), CD4(+), CD8(+), CD4(+)/CD8(+) of TLR2 and TLR4 in control group were (52.18±2.14)%, （27.28±1.19）%,（24.21±1.65）%,1.22±0.18,0.62±0.04 and 0.57±0.05, respectively, after treatment; while these indicators in LdBT group were （52.18±2.14）%,（30.97±2.01）%,（27.08±1.55）%,1.39±0.24,0.91±0.06 and 0.87±0.07, respectively, and above-mentioned indicators in LdBT group were significantly higher than those in control group（P<0.05）. Compared with these indicators before treatment, CD3(+), CD4(+), CD8(+) and CD4(+)/CD8(+) in the patients increased significantly（P<0.05）. The efficiency was 92.00% (46/50) in LdBT group, and 84.00% (42/50) in control group, without statistically significant difference（P>0.05）. The rate of side effects in study group was 6% (3/50), 18% (9/50) in control group, with statistically significance difference （P<0.05）.
  
  
  CONCLUSIONS
  Leukodeplated blood transfusion can improve the cellular immunity of AL patients, and reduce the rate of side effects.
authors.affiliation: Department of Hematology, Huangshi Central Hospital,Huangshi 435000, Hubei Province, China.
authors.forename: Ya-Lan
authors.initials: YL
authors.lastname: Lu
authors.affiliation: Department of Hematology, Huangshi Central Hospital,Huangshi 435000, Hubei Province, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Department of Hematology, Huangshi Central Hospital,Huangshi 435000, Hubei Province, China.
authors.forename: Yu-Fang
authors.initials: YF
authors.lastname: Wang
authors.affiliation: Department of Hematology, Huangshi Central Hospital,Huangshi 435000, Hubei Province, China.
authors.forename: Shan-Dong
authors.initials: SD
authors.lastname: Ke
authors.affiliation: Department of Hematology, Huangshi Central Hospital,Huangshi 435000, Hubei Province, China.
authors.forename: Jin-Yong
authors.initials: JY
authors.lastname: Ke
authors.affiliation: Department of Blood Transfusion, Huangshi Central Hospital,Huangshi 435000, Hubei Province, China.
authors.forename: Geng-Fu
authors.initials: GF
authors.lastname: Liu
authors.affiliation: Department of Hematology, Huangshi Central Hospital,Huangshi 435000, Hubei Province, China.E-mail: hbcsm73@163.com.
authors.forename: Shi-Ming
authors.initials: SM
authors.lastname: Chen
mesh_terms: D000208:Acute Disease; D001803:Blood Transfusion; D006801:Humans; D007111:Immunity, Cellular; D007938:Leukemia; D013601:T-Lymphocytes