title: O-GlcNAcylation, enemy or ally during cardiac hypertrophy development?
abstract: O-linked attachment of the monosaccharide β-N-acetyl-glucosamine (O-GlcNAcylation) is a post-translational modification occurring on serine and threonine residues, which is evolving as an important mechanism for the regulation of various cellular processes. The present review will, first, provide a general background on the molecular regulation of protein O-GlcNAcylation and will summarize the role of this post-translational modification in various acute cardiac pathologies including ischemia-reperfusion. Then, we will focus on research studies examining protein O-GlcNAcylation in the context of cardiac hypertrophy. A particular emphasis will be laid on the convergent but also divergent actions of O-GlcNAcylation according to the type of hypertrophy investigated, including physiological, pressure overload-induced and diabetes-linked cardiac hypertrophy. In an attempt to distinguish whether O-GlcNAcylation is detrimental or beneficial, this review will present the different O-GlcNAcylated targets involved in hypertrophy development. We will finally argue on potential interest to target O-GlcNAc processes to treat cardiac hypertrophy. This article is part of a Special Issue entitled: The role of post-translational protein modifications on heart and vascular metabolism edited by Jason R.B. Dyck & Jan F.C. Glatz.
authors.affiliation: Université catholique de Louvain, Institut de Recherche Expérimentale et Clinique, Pole of Cardiovascular Research, Brussels, Belgium.
authors.forename: Florence
authors.initials: F
authors.lastname: Mailleux
authors.affiliation: Montreal Heart Institute, Montreal, Canada; Department of Medicine, Université de Montréal, Montreal, Canada.
authors.forename: Roselle
authors.initials: R
authors.lastname: Gélinas
authors.affiliation: Université catholique de Louvain, Institut de Recherche Expérimentale et Clinique, Pole of Cardiovascular Research, Brussels, Belgium; Cliniques Universitaires Saint-Luc, Division of Cardiology, Brussels, Belgium.
authors.forename: Christophe
authors.initials: C
authors.lastname: Beauloye
authors.affiliation: Université catholique de Louvain, Institut de Recherche Expérimentale et Clinique, Pole of Cardiovascular Research, Brussels, Belgium.
authors.forename: Sandrine
authors.initials: S
authors.lastname: Horman
authors.affiliation: Université catholique de Louvain, Institut de Recherche Expérimentale et Clinique, Pole of Cardiovascular Research, Brussels, Belgium. Electronic address: luc.bertrand@uclouvain.be.
authors.forename: Luc
authors.initials: L
authors.lastname: Bertrand
mesh_terms: D000215:Acylation; D000818:Animals; D006332:Cardiomegaly / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D009124:Muscle Proteins / Q000378:metabolism*; D009206:Myocardium / Q000378:metabolism* / Q000473:pathology; D011499:Protein Processing, Post-Translational
chemical_list: D009124:Muscle Proteins
keywords: Cardiac disease; Cardiac hypertrophy; Diabetes; Glucose; Protein O-GlcNAcylation