title: Rho GTPases, their post-translational modifications, disease-associated mutations and pharmacological inhibitors.
abstract: The 20 members of the Rho GTPase family are key regulators of a wide-variety of biological activities. In response to activation, they signal via downstream effector proteins to induce dynamic alterations in the organization of the actomyosin cytoskeleton. In this review, post-translational modifications, mechanisms of dysregulation identified in human pathological conditions, and the ways that Rho GTPases might be targeted for chemotherapy will be discussed.
authors.affiliation: a Cancer Research UK Beatson Institute , Garscube Estate, Glasgow , UK.
authors.forename: Michael F
authors.initials: MF
authors.lastname: Olson
mesh_terms: D000818:Animals; D004194:Disease / Q000235:genetics*; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D006801:Humans; D009154:Mutation; D011499:Protein Processing, Post-Translational; D054875:Ubiquitination; D020741:rho GTP-Binding Proteins / Q000037:antagonists & inhibitors / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism*
chemical_list: D004791:Enzyme Inhibitors; D020741:rho GTP-Binding Proteins
keywords: CDC42; GTPase; Rac; Rho; actin; mutation; phosphorylation; signal transduction; ubiquitin