title: Self-Assembly of Proteins: Towards Supramolecular Materials.
abstract: The study of protein self-assembly has attracted great interest over the decades, due to the important role that proteins play in life. In contrast to the major achievements that have been made in the fields of DNA origami, RNA, and synthetic peptides, methods for the design of self-assembling proteins have progressed more slowly. This Concept article provides a brief overview of studies on native protein and artificial scaffold assemblies and highlights advances in designing self-assembling proteins. The discussions are focused on design strategies for self-assembling proteins, including protein fusion, chemical conjugation, supramolecular, and computational-aided de novo design.
authors.affiliation: Laboratory for Biomolecular Nanotechnology, MESA+ Institute for Nanotechnology, University of Twente, P.O. Box 217, 7500 AE, Enschede, The Netherlands.|Molecular Nanofabrication Group, MESA+ Institute for Nanotechnology, University of Twente, P.O. Box 217, 7500 AE, Enschede, The Netherlands.
authors.forename: Liulin
authors.initials: L
authors.lastname: Yang
authors.affiliation: Laboratory for Biomolecular Nanotechnology, MESA+ Institute for Nanotechnology, University of Twente, P.O. Box 217, 7500 AE, Enschede, The Netherlands.
authors.forename: Aijie
authors.initials: A
authors.lastname: Liu
authors.affiliation: Laboratory for Biomolecular Nanotechnology, MESA+ Institute for Nanotechnology, University of Twente, P.O. Box 217, 7500 AE, Enschede, The Netherlands.
authors.forename: Shuqin
authors.initials: S
authors.lastname: Cao
authors.affiliation: Laboratory for Biomolecular Nanotechnology, MESA+ Institute for Nanotechnology, University of Twente, P.O. Box 217, 7500 AE, Enschede, The Netherlands.
authors.forename: Rindia M
authors.initials: RM
authors.lastname: Putri
authors.affiliation: Molecular Nanofabrication Group, MESA+ Institute for Nanotechnology, University of Twente, P.O. Box 217, 7500 AE, Enschede, The Netherlands. P.Jonkheijm@utwente.nl.
authors.forename: Pascal
authors.initials: P
authors.lastname: Jonkheijm
authors.affiliation: Laboratory for Biomolecular Nanotechnology, MESA+ Institute for Nanotechnology, University of Twente, P.O. Box 217, 7500 AE, Enschede, The Netherlands. J.J.L.M.Cornelissen@utwente.nl.
authors.forename: Jeroen J L M
authors.initials: JJ
authors.lastname: Cornelissen
mesh_terms: D008958:Models, Molecular; D010455:Peptides / Q000138:chemical synthesis / Q000737:chemistry; D011506:Proteins / Q000737:chemistry*
chemical_list: D010455:Peptides; D011506:Proteins
keywords: chemical conjugation; protein fusion; proteins; self-assembly; supramolecular chemistry