title: The Prevalence of Celiac Disease in Children With Arterial Ischemic Stroke.
abstract: The association between arterial ischemic stroke (AIS) and celiac disease (CD) has been described in only a few cases in adults and children. We aim to determine the prevalence of CD in children and adolescents with AIS.
  
  
  
  We investigated serum levels of tissue transglutaminase antibody immunoglobulin (Ig)A and total IgA from 76 children with AIS and in a healthy control group of 102 children. Study participants who were positive for tissue transglutaminase IgA antibodies underwent a duodenal biopsy.
  
  
  
  A total of 2 patients in the AIS group (2.26%) and 2 in the control group (1.96%) had positive serum tissue transglutaminase antibody (P=0.89; 95% confidence interval, -5.05 to 6.89). Duodenal biopsy confirmed CD in only 1 patient who had AIS.
  
  
  
  In the present study, children with acute arterial stroke did not exhibit a higher prevalence rate of CD compared with healthy controls. Therefore, the screening test for CD is not a necessary part of the management of AIS in children. However, cases of recurrent AIS could be examined for CD.
authors.affiliation: *Department of Pediatric Gastroenterology, Hepatology and Nutrition, Kecioren Research and Training Hospital †Department of Pediatric Neurology, Baskent University Faculty of Medicine, Ankara, Turkey.
authors.forename: Oya
authors.initials: O
authors.lastname: Balci
authors.forename: Taner
authors.initials: T
authors.lastname: Sezer
mesh_terms: D000293:Adolescent; D000918:Antibody Specificity; D001323:Autoantibodies / Q000097:blood; D001324:Autoantigens / Q000276:immunology; D001706:Biopsy; D002545:Brain Ischemia / Q000453:epidemiology*; D002446:Celiac Disease / Q000097:blood / Q000453:epidemiology* / Q000276:immunology / Q000473:pathology; D002648:Child; D002675:Child, Preschool; D015897:Comorbidity; D004384:Duodenoscopy; D004386:Duodenum / Q000000981:diagnostic imaging / Q000473:pathology; D005260:Female; D019204:GTP-Binding Proteins / Q000276:immunology; D006801:Humans; D007070:Immunoglobulin A / Q000097:blood / Q000276:immunology; D008297:Male; D015995:Prevalence; D011446:Prospective Studies; D000091345:Protein Glutamine gamma Glutamyltransferase 2; D011503:Transglutaminases / Q000276:immunology; D014421:Turkey / Q000453:epidemiology
chemical_list: D001323:Autoantibodies; D001324:Autoantigens; D007070:Immunoglobulin A; D000091345:Protein Glutamine gamma Glutamyltransferase 2; D011503:Transglutaminases; D019204:GTP-Binding Proteins