title: Effects of chronic noise on mRNA and protein expression of CRF family molecules and its relationship with p-tau in the rat prefrontal cortex.
abstract: Chronic noise exposure has been associated with Alzheimer's disease (AD)-like pathological changes, such as tau hyperphosphorylation and β-amyloid peptide accumulation in the prefrontal cortex (PFC). Corticotropin-releasing factor (CRF) is the central driving force in the stress response and a regulator of tau phosphorylation via binding to CRF receptors (CRFR). Little is known about the CRF system in relation to noise-induced AD-like changes in the PFC. The aim of this study was to explore the effects of chronic noise exposure on the CRF system in the PFC of rats and its relationship to tau phosphorylation. Male Wistar rats were randomly divided into control and noise exposure groups. The CRF system was evaluated following chronic noise exposure (95dB sound pressure level white noise, 4h/day×30days). Chronic noise significantly accelerated the progressive overproduction of corticosterone and upregulated CRF and CRFR1 mRNA and protein, both of which persisted 7-14days after noise exposure. In contrast, CRFR2 was elevated 3-7days following the last stimulus. Double-labeling immunofluorescence co-localized p-tau with CRF in PFC neurons. The results suggest that chronic noise exposure elevates the expression of the CRF system, which may contribute to AD-like changes.
authors.affiliation: Shandong Academy of Medical Sciences, Shandong Institute of Prevention and Control of Occupational Health and Occupational Disease, Jinan 250062, China; Department of Occupational Hygiene, Institute of Health and Environmental Medicine, Tianjin 300050, China.
authors.forename: Zhihui
authors.initials: Z
authors.lastname: Gai
authors.affiliation: Department of Occupational Hygiene, Institute of Health and Environmental Medicine, Tianjin 300050, China.
authors.forename: Kang
authors.initials: K
authors.lastname: Li
authors.affiliation: Department of Occupational Hygiene, Institute of Health and Environmental Medicine, Tianjin 300050, China.
authors.forename: Huanrui
authors.initials: H
authors.lastname: Sun
authors.affiliation: Department of Occupational Hygiene, Institute of Health and Environmental Medicine, Tianjin 300050, China.
authors.forename: Xiaojun
authors.initials: X
authors.lastname: She
authors.affiliation: Department of Occupational Hygiene, Institute of Health and Environmental Medicine, Tianjin 300050, China. Electronic address: iamcuib@sina.com.
authors.forename: Bo
authors.initials: B
authors.lastname: Cui
authors.affiliation: Shandong Academy of Medical Sciences, Shandong Institute of Prevention and Control of Occupational Health and Occupational Disease, Jinan 250062, China. Electronic address: 13075308745@163.com.
authors.forename: Rui
authors.initials: R
authors.lastname: Wang
mesh_terms: D000161:Acoustic Stimulation / Q000379:methods; D000818:Animals; D003345:Corticosterone / Q000097:blood; D003346:Corticotropin-Releasing Hormone / Q000235:genetics* / Q000378:metabolism*; D004195:Disease Models, Animal; D004797:Enzyme-Linked Immunosorbent Assay; D005786:Gene Expression Regulation / Q000502:physiology; D008297:Male; D009622:Noise / Q000009:adverse effects*; D017397:Prefrontal Cortex / Q000378:metabolism*; D012333:RNA, Messenger / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D018019:Receptors, Corticotropin-Releasing Hormone / Q000235:genetics* / Q000378:metabolism*; D013315:Stress, Psychological / Q000209:etiology / Q000378:metabolism; D013997:Time Factors; D016875:tau Proteins / Q000378:metabolism*
chemical_list: D012333:RNA, Messenger; D018019:Receptors, Corticotropin-Releasing Hormone; D016875:tau Proteins; D003346:Corticotropin-Releasing Hormone; D003345:Corticosterone
keywords: Corticotropin-releasing factor; Corticotropin-releasing factor receptors; Noise; Phosphorylated tau; Prefrontal cortex