title: Copper-TEMPO-catalyzed synthesis of α-ketoamides via tandem sp(3)C-H aerobic oxidation and amination of phenethyl alcohol derivatives.
abstract: An efficient copper-TEMPO-catalyzed one-pot synthesis of α-ketoamides from phenethyl alcohol derivatives was developed firstly. Moreover, molecular oxygen in open air was employed as the oxidant with a broad substrate scope, which makes this methodology more practical. Based on some control experiments, a plausible mechanism was proposed.
authors.affiliation: College of Biotechnology and Pharmaceutical Engineering Nanjing Tech University 30 Puzhu South Road, Nanjing, 211816, China. guok@njtech.edu.cn fzcpu@163.com.
authors.forename: Chengkou
authors.initials: C
authors.lastname: Liu
authors.forename: Zhao
authors.initials: Z
authors.lastname: Yang
authors.forename: Shiyu
authors.initials: S
authors.lastname: Guo
authors.forename: Yu
authors.initials: Y
authors.lastname: Zeng
authors.forename: Ning
authors.initials: N
authors.lastname: Zhu
authors.forename: Xin
authors.initials: X
authors.lastname: Li
authors.forename: Zheng
authors.initials: Z
authors.lastname: Fang
authors.forename: Kai
authors.initials: K
authors.lastname: Guo