title: Successful Treatment of Cutaneous Leishmaniasis with Topical Paramomycin in a Child After Treatment Failure with Systemic Fluconazole.
abstract: It is challenging to find safe, nonscarring and noninvasive treatment of facial cutaneous leishmaniasis (CL) in children. Herein, we report a child with CL from a region endemic for Leishmania tropica, whose lesion persisted after treatment with oral fluconazole but responded to topical paromomycin. Paromomycin should be considered early for treatment of Old World CL and is a well-tolerated and effective mode of therapy for facial lesions.
authors.affiliation: Division of Infectious Diseases, Hospital for Sick Children, Toronto, Canada.
authors.forename: Anila
authors.initials: A
authors.lastname: Chacko
authors.affiliation: Department of Pediatrics, University of Toronto, Toronto, Canada. Division of Dermatology, Women's College Hospital, University of Toronto, Toronto, Canada.
authors.forename: Marissa
authors.initials: M
authors.lastname: Joseph
authors.affiliation: Lifelabs Medical Laboratory Services, Toronto, Canada.
authors.forename: Timothy
authors.initials: T
authors.lastname: Feltis
authors.affiliation: Division of Infectious Diseases, Hospital for Sick Children, Toronto, Canada. Department of Pediatrics, University of Toronto, Toronto, Canada. Centre for Global Child Health, Peter Gilgan Centre for Research and Learning, Hospital for Sick Children Research Institute, Toronto, Canada. shaun.morris@sickkids.ca.
authors.forename: Shaun K
authors.initials: SK
authors.lastname: Morris
mesh_terms: D000284:Administration, Oral; D000287:Administration, Topical; D000981:Antiprotozoal Agents / Q000627:therapeutic use*; D002675:Child, Preschool; D015725:Fluconazole / Q000627:therapeutic use; D005546:Forehead / Q000469:parasitology / Q000473:pathology; D006801:Humans; D007895:Leishmania tropica / Q000187:drug effects* / Q000302:isolation & purification; D016773:Leishmaniasis, Cutaneous / Q000175:diagnosis / Q000188:drug therapy* / Q000469:parasitology; D008297:Male; D010303:Paromomycin / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D000981:Antiprotozoal Agents; D010303:Paromomycin; D015725:Fluconazole