title: A Number of Cases in Iran Presenting with Coinheritance of Hemoglobin-H Disease and Beta-Thalassemia Minor.
abstract: Thalassemias are a group of inherited hematological disorders caused by defects in the synthesis of one or more of the hemoglobin (Hb) chains. The β- and α-thalassemias are widespread throughout the Mediterranean region, the Middle East, and Southeast Asia including Iran. In this study, we report five patients known to carry a coinheritance of Hb H (β4) disease and β-thalassemia (β-thal) minor. There is a high prevalence of consanguineous marriages in our population and the high rate of thalassemia determinants can cause coinheritance of α- and β-thal. Therefore, it is of special interest to report coinheritance of Hb H disease and β-thal minor which could lead to misdiagnosis.
authors.affiliation: a Hematology Research Center, Shiraz University of Medical Sciences , Shiraz , Iran.
authors.forename: Tahereh
authors.initials: T
authors.lastname: Zarei
authors.affiliation: b Hematology Research Center, Dastgheib Hospital, Shiraz University of Medical Sciences , Shiraz , Iran.
authors.forename: Javad
authors.initials: J
authors.lastname: Dehbozorgian
authors.affiliation: b Hematology Research Center, Dastgheib Hospital, Shiraz University of Medical Sciences , Shiraz , Iran.
authors.forename: Jaber
authors.initials: J
authors.lastname: Imanifard
authors.affiliation: b Hematology Research Center, Dastgheib Hospital, Shiraz University of Medical Sciences , Shiraz , Iran.
authors.forename: Fatemehsadat
authors.initials: F
authors.lastname: Setoodegan
authors.affiliation: a Hematology Research Center, Shiraz University of Medical Sciences , Shiraz , Iran.
authors.forename: Mehran
authors.initials: M
authors.lastname: Karimi
mesh_terms: D003241:Consanguinity; D003937:Diagnosis, Differential; D003951:Diagnostic Errors / Q000517:prevention & control; D005260:Female; D006801:Humans; D007492:Iran; D008297:Male; D017085:alpha-Thalassemia / Q000453:epidemiology*; D017086:beta-Thalassemia / Q000453:epidemiology*
keywords: Hb H; genetic association; β-Thalassemia (β-thal)