title: The Effectiveness of a Three Day Course Antibiotic Post-urodynamic Study in Preventing Lower Urinary Tract Infection.
abstract: OBJECTIVE
  to evaluate the effect of a 3-day course antibiotic post-urodynamic study (UDS) to prevent urinary tract infection (UTI).
  
  
  METHODS
  this was a randomized double blind clinical trial on the proportion of UTI in patients who received levofloxacin 500 mg once a day for 3 days after UDS compared to nontreated patients. The outcome of this study was the incidence of lower UTI in levofloxacin group and placebo group. Lower UTI was defined as patient with one or more clinical symptoms of lower UTI and one or more urinalysis parameter of UTI. Chi-square was used to evaluate the association between the lower UTI and treatment group.
  
  
  RESULTS
  a total of 126 patients were enrolled in this study from two outpatient urology clinics in Jakarta: Cipto Mangunkusumo Hospital and Asri Hospital. Overall, 26 patients (20.6%) had UTI post UDS (8 out of 63 patients from levofloxacin arm (12.7%) and 18 out of 63 patients from placebo arm (28.6%); p=0.028). The most common isolate found was E. coli (n=18 patients; 69.2%). The most common indications to perform UDS were Lower Urinary Tract Symptoms (LUTS) with failure of therapy (n=43 patients; 25%), LUTS after invasive treatment (n=29 patients; 16.9%), and overactive bladder with failure of therapy (n=22 patients; 12.7%).
  
  
  CONCLUSIONS
  the use of antibiotic post-UDS can prevent incidence of lower UTI.
authors.affiliation: Department of Urology, Faculty of Medicine, Universitas Indonesia - Cipto Mangunkusumo Hospital, Jakarta, Indonesia.
authors.forename: Harrina E
authors.initials: HE
authors.lastname: Rahardjo
authors.forename: Pande M W
authors.initials: PM
authors.lastname: Tirtayasa
authors.forename: Andika
authors.initials: A
authors.lastname: Afriansyah
authors.forename: Dyandra
authors.initials: D
authors.lastname: Parikesit
authors.forename: Muhammad I
authors.initials: MI
authors.lastname: Akbar
mesh_terms: D000328:Adult; D000368:Aged; D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D015994:Incidence; D007214:Indonesia; D064704:Levofloxacin / Q000008:administration & dosage*; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D014552:Urinary Tract Infections / Q000517:prevention & control*; D014556:Urine / Q000382:microbiology*; D014563:Urodynamics / Q000187:drug effects*
chemical_list: D000900:Anti-Bacterial Agents; D064704:Levofloxacin