title: Catheter-Directed Thrombolysis via Small Saphenous Veins for Treating Acute Deep Venous Thrombosis.
abstract: BACKGROUND There is little data comparing catheter-directed thrombolysis (CDT) via small saphenous veins vs. systematic thrombolysis on complications and efficacy in acute deep venous thrombosis patients. The aim of our study was to compare the efficacy and safety of CDT via the small saphenous veins with systematic thrombolysis for patients with acute deep venous thrombosis (DVT). MATERIAL AND METHODS Sixty-six patients with acute DVT admitted from June 2012 to December 2013 were divided into 2 groups: 27 patients received systemic thrombolysis (ST group) and 39 patients received CDT via the small saphenous veins (CDT group). The thrombolysis efficiency, limb circumference differences, and complications such as post-thrombotic syndrome (PTS) in the 2 groups were recorded. RESULTS The angiograms demonstrated that all or part of the fresh thrombus was dissolved. There was a significant difference regarding thrombolysis efficiency between the CDT group and ST group (71.26% vs. 48.26%, P=0.001). In both groups the postoperative limb circumference changes were higher compared to the preoperative values. The differences between postoperative limb circumferences on postoperative days 7 and 14 were significantly higher in the CDT group than in the ST group (all P<0.05). The incidence of postoperative PTS in the CDT group (17.9%) was significantly lower in comparison to the ST group (51.85%) during the follow-up (P=0.007). CONCLUSIONS Catheter-directed thrombolysis via the small saphenous veins is an effective, safe, and feasible approach for treating acute deep venous thrombosis.
authors.affiliation: Department of Vascular Surgery, Jining First People's Hospital, Jining, Shandong, China (mainland).
authors.forename: Bin
authors.initials: B
authors.lastname: Yang
authors.affiliation: Department of Internal Medicine, Tai'an Disabled Soldiers Hospital, Taian, Shandong, China (mainland).
authors.forename: Xiao-Dong
authors.initials: XD
authors.lastname: Xu
authors.affiliation: Department of Vascular Surgery, Jining First People's Hospital, Jining, Shandong, China (mainland).
authors.forename: Peng
authors.initials: P
authors.lastname: Gao
authors.affiliation: Department of Vascular Surgery, Jining First People's Hospital, Jining, Shandong, China (mainland).
authors.forename: Ji-Xiang
authors.initials: JX
authors.lastname: Yu
authors.affiliation: Department of Vascular Surgery, Jining First People's Hospital, Jining, Shandong, China (mainland).
authors.forename: Yu
authors.initials: Y
authors.lastname: Li
authors.affiliation: Department of Vascular Surgery, Jining First People's Hospital, Jining, Shandong, China (mainland).
authors.forename: Ai-Dong
authors.initials: AD
authors.lastname: Zhu
authors.affiliation: Department of Vascular Surgery, Jining First People's Hospital, Jining, Shandong, China (mainland).
authors.forename: Ran-Ran
authors.initials: RR
authors.lastname: Meng
mesh_terms: D057785:Catheters; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010690:Phlebography; D012501:Saphenous Vein / Q000473:pathology*; D015912:Thrombolytic Therapy / Q000009:adverse effects; D016896:Treatment Outcome; D014654:Vascular Patency; D020246:Venous Thrombosis / Q000503:physiopathology / Q000628:therapy*