title: [BMAL1 gene regulates the osteogenic differentiation of bone marrow mesenchymal stem cells].
abstract: Periodontitis is a chronic infective disease characterized as the destruction of the supporting tissues of the teeth. Bone marrow mesenchymal stem cells, which are ideal adult stem cells for the regeneration of supporting tissues, may play important roles in restoring the structure and function of the periodontium and in promoting the treatment of periodontal disease. As a consequence, the characteristics, especially osteogenic differentiation mechanism, of these stem cells have been extensively investigated. The regulation of the physiological behavior of these stem cells is associated with BMAL1 gene. This gene is a potential treatment target for periodontal disease, although the specific mechanism remains inconclusive. This study aimed to describe the characteristics of BMAL1 gene and its ability to regulate the osteogenic differentiation of stem cells.
authors.forename: Li
authors.initials: L
authors.lastname: Xiaoguang
authors.forename: Guo
authors.initials: G
authors.lastname: Xiao-long
authors.forename: Guo
authors.initials: G
authors.lastname: Bin
mesh_terms: D056930:ARNTL Transcription Factors / Q000235:genetics*; D000328:Adult; D053687:Adult Stem Cells; D001854:Bone Marrow Cells / Q000502:physiology*; D002454:Cell Differentiation; D006412:Hematopoietic Stem Cells; D006801:Humans; D059630:Mesenchymal Stem Cells / Q000502:physiology*; D010012:Osteogenesis / Q000502:physiology*; D010513:Periodontal Ligament; D010518:Periodontitis; D010519:Periodontium; D012038:Regeneration; D014070:Tooth
chemical_list: D056930:ARNTL Transcription Factors