title: Transient Elastography with Serum Hepatitis B Surface Antigen Enhances Liver Fibrosis Detection.
abstract: BACKGROUND The aim of this study was to explore transient elastography (TE) with quantitative hepatitis B surface antigen (qHBsAg) for detecting advanced hepatic fibrosis. MATERIAL AND METHODS This was a single-center prospective real-life analysis of 111 treatment-naïve chronic hepatitis B (CHB) patients enrolled into the Establishment of Non-invasive Diagnosis Criteria and Model of Hepatitis B Virus-related Cirrhosis Study. RESULTS There were significant correlations between TE, qHBsAg, and fibrosis. Both qHBsAg and TE were identified as independent predictors for advanced fibrosis. In receiver operating characteristic curve (ROC) analysis, TEqHBsAg (combination of TE and qHBsAg) resulted in the highest area under the receiver-operator curve (AUC) (0.912), mainly due to increased specificity. Using the optimal cut-off, TEqHBsAg provided a sensitivity of 86.7%, and increased specificity from 78.7% to 85.1%. CONCLUSIONS Combining TE with qHBsAg enhances specificity in identifying advanced fibrosis in treatment-naïve CHB patients.
authors.affiliation: Department of Cardiology, Capital Medical University Affiliated Beijing Anzhen Hospital, Beijing Institute of Heart, Lung and Blood Vessel Diseases, Beijing, China (mainland).
authors.forename: Tianyi
authors.initials: T
authors.lastname: Dai
authors.affiliation: Department of Infectious Diseases, JiaYuguan's First Hospital, Jiayuguan, Gansu, China (mainland).
authors.forename: Jia
authors.initials: J
authors.lastname: Si
authors.affiliation: Department of Ultrasound, Japan-China Friendship Hospital, Beijing, China (mainland).
authors.forename: Meina
authors.initials: M
authors.lastname: Hao
authors.affiliation: Department of Ultrasound, Japan-China Friendship Hospital, Beijing , China (mainland).
authors.forename: Cheng
authors.initials: C
authors.lastname: Li
authors.affiliation: Department of Pathology, Japan-China Friendship Hospital, Beijing, China (mainland).
authors.forename: Xia
authors.initials: X
authors.lastname: Liu
authors.affiliation: Department of Pathology, Japan-China Friendship Hospital, Beijing, China (mainland).
authors.forename: Jie
authors.initials: J
authors.lastname: Li
authors.affiliation: Department of Infectious Diseases, Japan-China Friendship Hospital, Beijing, China (mainland).
authors.forename: Anlin
authors.initials: A
authors.lastname: Ma
mesh_terms: D000328:Adult; D001706:Biopsy; D002681:China; D054459:Elasticity Imaging Techniques / Q000379:methods; D005260:Female; D006514:Hepatitis B Surface Antigens / Q000097:blood*; D006515:Hepatitis B virus / Q000302:isolation & purification; D019694:Hepatitis B, Chronic / Q000097:blood / Q000175:diagnosis; D006801:Humans; D008099:Liver / Q000473:pathology; D008103:Liver Cirrhosis / Q000097:blood* / Q000000981:diagnostic imaging* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012372:ROC Curve
chemical_list: D006514:Hepatitis B Surface Antigens