title: Double-blind, placebo-controlled pilot trial of anthocyanin-rich purple sweet potato beverage on serum hepatic biomarker levels in healthy Caucasians with borderline hepatitis.
abstract: The objective is to evaluate the efficacy of anthocyanin-rich purple-fleshed sweet potato (PSP) beverage on the serum levels of gamma-glutamyl transferase (GGT), aspartate aminotransferase (AST) and alanine aminotransferase (ALT) in healthy Caucasians with borderline hepatitis. Forty healthy Caucasians (41-69 years) consumed three bottles of the PSP beverage (177 mg anthocyanins per 125-ml bottle) or placebo (1.3 mg) per day for 8 weeks. Thirty-nine subjects completed the study and two subjects were excluded from statistical analysis. GGT levels in the PSP group on days 15 and 43 were lower (P=0.077 and 0.038, respectively), AST levels in the PSP group on days 29 and 43 were lower (P=0.010 and 0.045, respectively) and ALT level in the PSP group on day 43 was lower (P=0.037) than in the placebo group. The PSP beverage did not induce clinically relevant changes in other blood and clinical chemistry parameters.
authors.affiliation: Kyushu Okinawa Agricultural Research Center, National Agriculture and Food Research Organization, Koshi, Kumamoto, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Oki
authors.affiliation: Yakult Central Institute, Kunitachi, Tokyo, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Kano
authors.affiliation: Yakult Central Institute, Kunitachi, Tokyo, Japan.
authors.forename: F
authors.initials: F
authors.lastname: Ishikawa
authors.affiliation: Agri-Food Business Innovation Center, National Agriculture and Food Research Organization, Tsukuba, Ibaraki, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Goto
authors.affiliation: Faculty of Research and Development, Yakult Honsha Co., Ltd., Minato, Tokyo, Japan.
authors.forename: O
authors.initials: O
authors.lastname: Watanabe
authors.affiliation: Kyushu Okinawa Agricultural Research Center, National Agriculture and Food Research Organization, Koshi, Kumamoto, Japan.
authors.forename: I
authors.initials: I
authors.lastname: Suda
mesh_terms: D000328:Adult; D000368:Aged; D000410:Alanine Transaminase / Q000097:blood; D000872:Anthocyanins / Q000008:administration & dosage*; D001219:Aspartate Aminotransferases / Q000097:blood; D001628:Beverages; D015415:Biomarkers / Q000097:blood; D004311:Double-Blind Method; D005260:Female; D064368:Healthy Volunteers; D006505:Hepatitis / Q000097:blood*; D006801:Humans; D027723:Ipomoea batatas / Q000737:chemistry*; D008297:Male; D008875:Middle Aged; D010865:Pilot Projects; D044465:White People; D005723:gamma-Glutamyltransferase / Q000097:blood
chemical_list: D000872:Anthocyanins; D015415:Biomarkers; D005723:gamma-Glutamyltransferase; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase