title: Metabolic Complications and Glucose Metabolism in HIV Infection: A Review of the Evidence.
abstract: HIV infection and antiretroviral therapy (ART) use are associated with perturbations in glucose and lipid metabolism. Increasing incidence of diabetes, cardiovascular disease, and obesity highlights the need for early identification and treatment of metabolic dysfunction. Newer ART regimens are less toxic for cellular function and metabolism but have failed to completely eliminate metabolic dysfunction with HIV infection. Additional factors, including viral-host interactions, diet, physical activity, non-ART medications, and aging may further contribute to metabolic disease risk in the HIV setting. We summarize the recent literature regarding the impact on metabolic function of HIV infection, ART, and pharmaceutical or lifestyle prescriptions.
authors.affiliation: Division of Infectious Diseases. UAB Center for AIDS Research, University of Alabama School of Medicine, 845 19th Street South, BBRB 207, Birmingham, AL, 35294, USA.
authors.forename: Amanda L
authors.initials: AL
authors.lastname: Willig
authors.affiliation: Division of Infectious Diseases, University of Alabama School of Medicine, 908 20th St, South, CCB Rm 330A, Birmingham, AL, 35294, USA. eoverton@uabmc.edu.
authors.forename: Edgar Turner
authors.initials: ET
authors.lastname: Overton
mesh_terms: D019380:Anti-HIV Agents / Q000009:adverse effects*; D023241:Antiretroviral Therapy, Highly Active / Q000009:adverse effects; D002318:Cardiovascular Diseases / Q000209:etiology / Q000378:metabolism* / Q000503:physiopathology; D050171:Dyslipidemias / Q000209:etiology / Q000378:metabolism* / Q000503:physiopathology; D019317:Evidence-Based Medicine; D005947:Glucose / Q000378:metabolism*; D015658:HIV Infections / Q000188:drug therapy* / Q000378:metabolism*; D006801:Humans; D007333:Insulin Resistance; D050356:Lipid Metabolism / Q000187:drug effects; D024821:Metabolic Syndrome / Q000209:etiology / Q000378:metabolism* / Q000503:physiopathology; D040242:Risk Reduction Behavior
chemical_list: D019380:Anti-HIV Agents; D005947:Glucose
keywords: ART; Adipose tissue; Complications in HIV infection; Fat; Glucose; HIV; Inflammation; Metabolism