title: Cytotoxicity of Naturally Occurring Isoquinoline Alkaloids of Different Structural Types.
abstract: Forty-six isoquinoline alkaloids, of eleven structural types isolated in our laboratory, have been evaluated for their cytotoxicity against two cancer cell lines (Caco-2 and Hep-G2 cancer cells), as well as against normal human lung fibroblast cells. Only scoulerine, aromoline, berbamine and parfumidine showed significant cytotoxic effects, but only scoulerine was active against both Caco-2 and Hep-G2 cells (IC50 values 6.44 ± 0.87 and 4.57 ± 0.42, respectively). Unfortunately, except for parfumidine, the other active alkaloids were also cytotoxic to the normal human lung fibroblast cells.
authors.forename: Jakub
authors.initials: J
authors.lastname: Chlebek
authors.forename: Ivo
authors.initials: I
authors.lastname: Doskocil
authors.forename: Daniela
authors.initials: D
authors.lastname: Hulcová
authors.forename: Katerina
authors.initials: K
authors.lastname: Breiterová
authors.forename: Marcela
authors.initials: M
authors.lastname: Šafratová
authors.forename: Radim
authors.initials: R
authors.lastname: Havelek
authors.forename: Klára
authors.initials: K
authors.lastname: Habartová
authors.forename: Anna
authors.initials: A
authors.lastname: Hošt'álková
authors.forename: Tereza
authors.initials: T
authors.lastname: Volštátová
authors.forename: Lucie
authors.initials: L
authors.lastname: Cahlíková
mesh_terms: D000470:Alkaloids / Q000737:chemistry* / Q000633:toxicity*; D018938:Caco-2 Cells; D002470:Cell Survival / Q000187:drug effects; D056945:Hep G2 Cells; D006801:Humans; D007546:Isoquinolines / Q000737:chemistry* / Q000633:toxicity*
chemical_list: D000470:Alkaloids; D007546:Isoquinolines