title: Synthesis of Hydroxymethylenebisphosphonic Acid Derivatives in Different Solvents.
abstract: The syntheses of hydroxymethylenebisphosphonic acid derivatives (dronic acid derivatives) starting from the corresponding substituted acetic acids and P-reagents, mainly phosphorus trichloride and phosphorous acid are surveyed according to the solvents applied. The nature of the solvent is a critical point due to the heterogeneity of the reaction mixtures. This review sheds light on the optimum choice and ratio of the P-reactants, and on the optimum conditions.
authors.affiliation: Department of Organic Chemistry and Technology, Budapest University of Technology and Economics, 1521 Budapest, Hungary. duwa24@gmail.com.
authors.forename: Dávid Illés
authors.initials: DI
authors.lastname: Nagy
authors.affiliation: Department of Organic Chemistry and Technology, Budapest University of Technology and Economics, 1521 Budapest, Hungary. agrun@mail.bme.hu.
authors.forename: Alajos
authors.initials: A
authors.lastname: Grün
authors.affiliation: Gedeon Richter Plc., 1475 Budapest, Hungary. garadnay@richter.hu.
authors.forename: Sándor
authors.initials: S
authors.lastname: Garadnay
authors.affiliation: Gedeon Richter Plc., 1475 Budapest, Hungary. i.greiner@richter.hu.
authors.forename: István
authors.initials: I
authors.lastname: Greiner
authors.affiliation: Department of Organic Chemistry and Technology, Budapest University of Technology and Economics, 1521 Budapest, Hungary. gkeglevich@mail.bme.hu.
authors.forename: György
authors.initials: G
authors.lastname: Keglevich
mesh_terms: D004164:Diphosphonates / Q000737:chemistry*; D015394:Molecular Structure; D010757:Phosphorous Acids / Q000138:chemical synthesis* / Q000737:chemistry; D012997:Solvents
chemical_list: D004164:Diphosphonates; D010757:Phosphorous Acids; D012997:Solvents; C029285:hydroxymethanediphosphonic acid
keywords: P-reagents; hydroxymethylenebisphosphonic acid (dronic acid) derivatives; solvent; synthesis