title: Protein Nanocages for Delivery and Release of Luminescent Ruthenium(II) Polypyridyl Complexes.
abstract: In this report, noncovalent encapsulation of hydrophobic ruthenium(II) polyridyl complexes, Ru(bpy)2dppz(2+) and Ru(phen)2dppz(2+), into apoferritin cavity was achieved with high loading contents by effective prevention of Ru complex-induced protein aggregation, without disruption of protein native architecture. The Ru-loaded luminescent nanocomposites have demonstrated improved water solubility, easy manipulation, reduced cytotoxicity, and enhanced cellular uptake as compared to the nontreated Ru complexes.
authors.affiliation: Department of Polymer Science & Engineering, School of Chemistry & Chemical Engineering, Nanjing University , Nanjing 210023, P. R. China.
authors.forename: Xiao
authors.initials: X
authors.lastname: Li
authors.affiliation: Department of Polymer Science & Engineering, School of Chemistry & Chemical Engineering, Nanjing University , Nanjing 210023, P. R. China.
authors.forename: Yajie
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Department of Polymer Science & Engineering, School of Chemistry & Chemical Engineering, Nanjing University , Nanjing 210023, P. R. China.|Lab of Advanced Functional Materials, School of Environmental Science, Nanjing Xiaozhuang University , Nanjing 210013, P. R. China.
authors.forename: Hong
authors.initials: H
authors.lastname: Chen
authors.affiliation: Department of Polymer Science & Engineering, School of Chemistry & Chemical Engineering, Nanjing University , Nanjing 210023, P. R. China.
authors.forename: Jian
authors.initials: J
authors.lastname: Sun
authors.affiliation: Department of Polymer Science & Engineering, School of Chemistry & Chemical Engineering, Nanjing University , Nanjing 210023, P. R. China.
authors.forename: Fude
authors.initials: F
authors.lastname: Feng
keywords: cell imaging; drug delivery; encapsulation; luminescence; protein nanocage