title: Molecular Detection of Gastrointestinal Neoplasia: Innovations in Early Detection and Screening.
abstract: Emerging molecular tools promise to extend the diagnostic reach of the endoscopist and open doors to population screening for gastrointestinal (GI) cancers. This review briefly addresses biological considerations in marker detection and types of markers, highlights examples of tools under development at each organ site, and appraises the possibility of universal GI cancer screening. The outlook is positive, but further technical refinement and rigorous clinical validation are needed before most of these new approaches are ready for clinical application.
authors.affiliation: Division of Gastroenterology & Hepatology, Mayo Clinic, Gonda Building E-9, 200 First Street SW, Rochester, MN 55905, USA.
authors.forename: Bradley W
authors.initials: BW
authors.lastname: Anderson
authors.affiliation: Division of Gastroenterology & Hepatology, Mayo Clinic, Gonda Building E-9, 200 First Street SW, Rochester, MN 55905, USA. Electronic address: ahlquist.david@mayo.edu.
authors.forename: David A
authors.initials: DA
authors.lastname: Ahlquist
mesh_terms: D014408:Biomarkers, Tumor / Q000235:genetics / Q000378:metabolism*; D015179:Colorectal Neoplasms / Q000175:diagnosis / Q000235:genetics / Q000378:metabolism; D004273:DNA, Neoplasm / Q000235:genetics; D055088:Early Detection of Cancer; D004938:Esophageal Neoplasms / Q000175:diagnosis / Q000235:genetics / Q000378:metabolism; D005243:Feces / Q000737:chemistry / Q000166:cytology; D005751:Gastric Lavage; D005770:Gastrointestinal Neoplasms / Q000175:diagnosis* / Q000235:genetics / Q000378:metabolism; D006801:Humans; D009360:Neoplastic Cells, Circulating; D010189:Pancreatic Juice / Q000737:chemistry / Q000166:cytology; D010190:Pancreatic Neoplasms / Q000175:diagnosis / Q000235:genetics / Q000378:metabolism; D012334:RNA, Neoplasm / Q000235:genetics
chemical_list: D014408:Biomarkers, Tumor; D004273:DNA, Neoplasm; D012334:RNA, Neoplasm
keywords: Blood testing; Early detection; Gastrointestinal cancer; Molecular markers; Screening; Stool testing