title: Relation of size of seminal vesicles on ultrasound to premature ejaculation.
abstract: Myriad biological factors have been proposed to explain premature ejaculation (PE). However, data correlating PE with seminal vesicles (SVs) are sparse. The study aimed to evaluate the relationship between the size of SV and PE. The cross-sectional study included 44 outpatients with PE and 44 volunteers without PE, and the size of SV was compared. Self-estimated intravaginal ejaculatory latency time, the Premature Ejaculation Diagnostic Tool (PEDT), the International Index of Erectile Function-15, and the National Institutes of Health-Chronic Prostatitis Symptom Index were used for assessment of symptoms. Compared to the control group, the PE group had significantly higher mean anterior-posterior diameter (APD) of SV (P < 0.001). The optimal mean APD of SV cutoff level was 9.25 mm for PE. In the PE group, PEDT was also higher with a mean APD of SV ≥9.25 mm compared with mean APD of SV <9.25 mm. PEDT was significantly correlated with the mean APD of SV (r = 0.326, P = 0.031). The seminal plasma proteins were compared between six PE and six matched control cases by mass spectrometry and it was shown that 102 proteins were at least 1.5-fold up- or down-regulated. Among them, GGT1, LAMC1, and APP were significantly higher in the PE group. These results indicated that men with a larger mean APD of SV might have a higher PEDT score. Transrectal ultrasound of SV should be considered in the evaluation of patients with premature ejaculation. SV might be a potential target for the treatment of patients with PE and ultrasound change in SV.
authors.affiliation: Center for Reproductive Medicine, Jinling Hospital, Medical School of Nanjing University, Nanjing 210002, China.
authors.forename: Zhi-Wei
authors.initials: ZW
authors.lastname: Hong
authors.affiliation: Center for Reproductive Medicine, Jinling Hospital, Medical School of Nanjing University, Nanjing 210002, China.
authors.forename: Yu-Ming
authors.initials: YM
authors.lastname: Feng
authors.affiliation: Center for Reproductive Medicine, Jinling Hospital, Medical School of Nanjing University, Nanjing 210002, China.
authors.forename: Yi-Feng
authors.initials: YF
authors.lastname: Ge
authors.affiliation: Center for Reproductive Medicine, Jinling Hospital, Medical School of Nanjing University, Nanjing 210002, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Jing
authors.affiliation: Center for Reproductive Medicine, Jinling Hospital, Medical School of Nanjing University, Nanjing 210002, China.
authors.forename: Xue-Chun
authors.initials: XC
authors.lastname: Hu
authors.affiliation: Center for Reproductive Medicine, Jinling Hospital, Medical School of Nanjing University, Nanjing 210002, China.
authors.forename: Jia-Ming
authors.initials: JM
authors.lastname: Shen
authors.affiliation: Center for Reproductive Medicine, Jinling Hospital, Southern Medical University, Nanjing 210002, China.
authors.forename: Long-Ping
authors.initials: LP
authors.lastname: Peng
authors.affiliation: Center for Reproductive Medicine, Jinling Hospital, Medical School of Nanjing University, Nanjing 210002, China.
authors.forename: Bing
authors.initials: B
authors.lastname: Yao
authors.affiliation: Andrology Center, Peking University First Hospital, Peking University, Beijing 100009, China.
authors.forename: Zhong-Cheng
authors.initials: ZC
authors.lastname: Xin
mesh_terms: D000328:Adult; D000368:Aged; D000375:Aging; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D012739:Gonadal Steroid Hormones / Q000097:blood; D006801:Humans; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged; D061686:Premature Ejaculation / Q000000981:diagnostic imaging*; D012016:Reference Values; D029589:Seminal Plasma Proteins / Q000032:analysis / Q000235:genetics; D012669:Seminal Vesicles / Q000000981:diagnostic imaging*; D012959:Socioeconomic Factors; D014463:Ultrasonography; D018615:Ultrasonography, Doppler, Color; D036761:Ultrasound, High-Intensity Focused, Transrectal; D055815:Young Adult
chemical_list: D012739:Gonadal Steroid Hormones; D008055:Lipids; D029589:Seminal Plasma Proteins