title: Emestrins: Anti-Cryptococcus Epipolythiodioxopiperazines from Podospora australis.
abstract: Eleven emestrin-type epipolythiodioxopiperazines, including four new compounds, emestrins H-K (1-4), were isolated from the crude extracts of two strains of the coprophilous fungus Podospora australis. The structures of 1-4 were established primarily by analysis of NMR data, and the absolute configuration of C-6 in 1 was independently assigned using the modified Mosher method. Four of the known emestrins obtained (emestrins C-E and MPC1001C) were found to selectively inhibit the growth of Cryptococcus neoformans. These results also represent the first report of chemistry from any strain of P. australis.
authors.affiliation: Texas Therapeutic Institute, The Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston , Houston, Texas 77054, United States.
authors.forename: Yan
authors.initials: Y
authors.lastname: Li
authors.affiliation: Texas Therapeutic Institute, The Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston , Houston, Texas 77054, United States.
authors.forename: Qun
authors.initials: Q
authors.lastname: Yue
authors.affiliation: Department of Chemistry, University of Iowa , Iowa City, Iowa 52242, United States.
authors.forename: Nicole M
authors.initials: NM
authors.lastname: Krausert
authors.affiliation: Texas Therapeutic Institute, The Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston , Houston, Texas 77054, United States.
authors.forename: Zhiqiang
authors.initials: Z
authors.lastname: An
authors.affiliation: Department of Chemistry, University of Iowa , Iowa City, Iowa 52242, United States.
authors.forename: James B
authors.initials: JB
authors.lastname: Gloer
authors.affiliation: Texas Therapeutic Institute, The Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston , Houston, Texas 77054, United States.
authors.forename: Gerald F
authors.initials: GF
authors.lastname: Bills
mesh_terms: D000818:Animals; D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D003455:Cryptococcus neoformans / Q000187:drug effects*; D003672:Defecation; D006736:Horses; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010879:Piperazines / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D048468:Podospora / Q000737:chemistry*
chemical_list: D000935:Antifungal Agents; D010879:Piperazines; C067458:emestrin