title: Vitamin D Treatment Effect on Serum Endocan and High-Sensitivity C-Reactive Protein Levels in Renal Transplant Patients.
abstract: BACKGROUND
  Endocan is a marker showing endothelial dysfunction and inflammation. Significantly increased endocan levels have been observed in serum of patients with sepsis and cancer.
  
  
  OBJECTIVE
  Our aim was to investigate the relationship between vitamin D treatment and serum endocan and high-sensitivity C-reactive protein (hs-CRP) levels as inflammatory markers in transplant patients.
  
  
  METHODS
  Prospective.
  
  
  METHODS
  Nephrology clinic.
  
  
  METHODS
  Thirty-eight renal transplant patients with serum 25-hydroxy-vitamin D (25-OH-vitamin D) levels below 20 ng/mL and transplanted at least 12 months.
  
  
  METHODS
  One-time oral dose of 300 000 IU vitamin D3.
  
  
  METHODS
  Before and after vitamin D treatment, serum endocan, hs-CRP, calcium, phosphorus, and parathyroid hormone (PTH) levels were measured.
  
  
  RESULTS
  Median serum endocan and PTH values before vitamin D were significantly higher than those of after treatment values ( P = .001 and P < .001, respectively). On the other hand, serum total calcium and phosphorus levels before vitamin D treatment were lower than the values obtained after vitamin D treatment ( P = .0013 and P < .001, respectively). Serum hs-CRP was lower after vitamin D therapy than before, but the difference was not statistically significant ( P = .06). A moderate negative correlation was determined between endocan and 25-OH-vitamin D levels after treatment with vitamin D ( r = -.36, P = .02).
  
  
  CONCLUSIONS
  This study has revealed that vitamin D treatment reduced markers of endothelial dysfunction in patients with renal transplantation and vitamin D deficiency.
authors.affiliation: 1 Department of Medical Biology, Medical School, Ataturk University, Erzurum, Turkey.
authors.forename: Omer
authors.initials: O
authors.lastname: Atis
authors.affiliation: 2 Department of Nephrology, Medical School, Mevlana University, Konya, Turkey.
authors.forename: Mustafa
authors.initials: M
authors.lastname: Keles
authors.affiliation: 3 Department of Nephrology, Medical School, Ataturk University, Erzurum, Turkey.
authors.forename: Erdem
authors.initials: E
authors.lastname: Cankaya
authors.affiliation: 1 Department of Medical Biology, Medical School, Ataturk University, Erzurum, Turkey.
authors.forename: Hasan
authors.initials: H
authors.lastname: Dogan
authors.affiliation: 4 Department of Medical Biochemistry, Medical School, Ataturk University, Erzurum, Turkey.
authors.forename: Hulya
authors.initials: H
authors.lastname: Aksoy
authors.affiliation: 4 Department of Medical Biochemistry, Medical School, Ataturk University, Erzurum, Turkey.
authors.forename: Fatih
authors.initials: F
authors.lastname: Akcay
mesh_terms: D002097:C-Reactive Protein / Q000187:drug effects*; D006801:Humans; D016030:Kidney Transplantation; D010281:Parathyroid Hormone; D011446:Prospective Studies; D014807:Vitamin D / Q000494:pharmacology / Q000627:therapeutic use*; D014815:Vitamins / Q000494:pharmacology / Q000627:therapeutic use*
chemical_list: D010281:Parathyroid Hormone; D014815:Vitamins; D014807:Vitamin D; D002097:C-Reactive Protein
keywords: endocan; high-sensitivity C-reactive protein.; kidney transplantation; vitamin D