title: Cowden Syndrome Detected by FDG PET/CT in an Endometrial Cancer Patient.
abstract: Cowden syndrome (CS) is a rare autosomal dominant disorder characterized by multiple hamartomas in various tissues and cancers (breast, thyroid, and endometrium). We report CS of the esophagus and gastrointestinal tract that was incidentally detected by positron emission tomography/computed tomography (PET/CT) at postoperative surveillance in an endometrial cancer patient. PET/CT showed mildly increased FDG uptake along the entire esophagus and stomach. Upper GI endoscopy and histologic examination revealed glycogenic acanthosis of the esophagus and several hundred gastric polyps. In our case, increased FDG uptake of the esophageal wall contributed to the diagnosis of CS.
authors.affiliation: Department of Nuclear Medicine, Eulji University Hospital, 96 Dunsanseo-ro, Seo-gu, Daejeon, 35233 Republic of Korea.
authors.forename: Yun Hee
authors.initials: YH
authors.lastname: Kang
authors.affiliation: Department of Pathology, Eulji University Hospital, 96 Dunsanseo-ro, Seo-gu, Daejeon, 35233 Republic of Korea.
authors.forename: Hye Kyung
authors.initials: HK
authors.lastname: Lee
authors.affiliation: Department of Radiology, The Catholic University of Korea, Daejeon Saint Mary's Hospital, 64, Daeheung-ro, Jung-gu, Daejeon, 34943 Republic of Korea.
authors.forename: Geon
authors.initials: G
authors.lastname: Park
keywords: Cowden syndrome; Fluorodeoxyglucose F18; Hamartoma syndrome; Multiple; Positron emission tomography