title: The potential impact of bone tissue engineering in the clinic.
abstract: Bone tissue engineering (BTE) intends to restore structural support for movement and mineral homeostasis, and assist in hematopoiesis and the protective functions of bone in traumatic, degenerative, cancer, or congenital malformation. While much effort has been put into BTE, very little of this research has been translated to the clinic. In this review, we discuss current regenerative medicine and restorative strategies that utilize tissue engineering approaches to address bone defects within a clinical setting. These approaches involve the primary components of tissue engineering: cells, growth factors and biomaterials discussed briefly in light of their clinical relevance. This review also presents upcoming advanced approaches for BTE applications and suggests a probable workpath for translation from the laboratory to the clinic.
authors.affiliation: Department of Plastic Surgery, The Ohio State University, Columbus, OH, USA.
authors.forename: Ruchi
authors.initials: R
authors.lastname: Mishra
authors.affiliation: Department of Plastic Surgery, The Ohio State University, Columbus, OH, USA.
authors.forename: Tyler
authors.initials: T
authors.lastname: Bishop
authors.affiliation: Department of Plastic Surgery, The Ohio State University, Columbus, OH, USA.
authors.forename: Ian L
authors.initials: IL
authors.lastname: Valerio
authors.affiliation: Fischell Department of Bioengineering, University of Maryland, College Park, MD, USA.
authors.forename: John P
authors.initials: JP
authors.lastname: Fisher
authors.affiliation: Department of Plastic Surgery, The Ohio State University, Columbus, OH, USA.
authors.forename: David
authors.initials: D
authors.lastname: Dean
mesh_terms: D000818:Animals; D001847:Bone Diseases / Q000628:therapy*; D001861:Bone Regeneration / Q000502:physiology*; D001842:Bone and Bones / Q000166:cytology*; D006801:Humans; D023822:Tissue Engineering / Q000379:methods*
keywords: 3D printing; additive manufacturing; biomaterials; bioreactor; bone tissue engineering; cell-based therapy