title: Synthesis and in vitro antiproliferative evaluation of novel nonsymmetrical disulfides bearing 1,3,4-oxadiazole moiety.
abstract: A series of novel nonsymmetrical disulfides bearing 1,3,4-oxadiazole moiety were designed, synthesized and evaluated for their in vitro antiproliferative activities against SMMC-7721, Hela and A549 human cancer cell lines by CCK-8 assay. The preliminary bioassay results demonstrated that all tested compounds 7a-7o exhibited antiproliferation with different degrees, and some compounds showed better effects than positive control 5-fluorouracil against various cancer cell lines. Among these compounds, compound 7j showed significant antiproliferative activity against SMMC-7721 cells with IC50 value of 3.40μM. Compound 7a displayed highly effective biological activity against Hela cells with IC50 value of 4.26μM. Compound 7g exhibited the best inhibitory effect against A549 cells with IC50 value of 6.26μM.
authors.affiliation: Department of Chemistry and Chemical Engineering, Tianjin University of Technology, Tianjin 300384, PR China.
authors.forename: Ji-Jun
authors.initials: JJ
authors.lastname: Zhao
authors.affiliation: Department of Chemistry and Chemical Engineering, Tianjin University of Technology, Tianjin 300384, PR China.
authors.forename: Xue-Feng
authors.initials: XF
authors.lastname: Wang
authors.affiliation: Department of Chemistry and Chemical Engineering, Tianjin University of Technology, Tianjin 300384, PR China.
authors.forename: Bao-Lin
authors.initials: BL
authors.lastname: Li
authors.affiliation: Department of Chemistry and Chemical Engineering, Tianjin University of Technology, Tianjin 300384, PR China.
authors.forename: Rui-Lian
authors.initials: RL
authors.lastname: Zhang
authors.affiliation: Department of Chemistry and Chemical Engineering, Tianjin University of Technology, Tianjin 300384, PR China.
authors.forename: Bo
authors.initials: B
authors.lastname: Li
authors.affiliation: Department of Chemistry and Chemical Engineering, Tianjin University of Technology, Tianjin 300384, PR China.
authors.forename: Yu-Ming
authors.initials: YM
authors.lastname: Liu
authors.affiliation: Department of Chemistry and Chemical Engineering, Tianjin University of Technology, Tianjin 300384, PR China.
authors.forename: Cai-Wen
authors.initials: CW
authors.lastname: Li
authors.affiliation: Department of Chemistry and Chemical Engineering, Tianjin University of Technology, Tianjin 300384, PR China.
authors.forename: Jin-Biao
authors.initials: JB
authors.lastname: Liu
authors.affiliation: Department of Chemistry and Chemical Engineering, Tianjin University of Technology, Tianjin 300384, PR China. Electronic address: chenbaoquan66@126.com.
authors.forename: Bao-Quan
authors.initials: BQ
authors.lastname: Chen
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D045744:Cell Line, Tumor; D004220:Disulfides / Q000737:chemistry*; D005472:Fluorouracil / Q000494:pharmacology; D006801:Humans; D020128:Inhibitory Concentration 50; D010069:Oxadiazoles / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D004220:Disulfides; D010069:Oxadiazoles; C583463:1,3,4-oxadiazole; D005472:Fluorouracil
keywords: 1,3,4-Oxadiazole; Antiproliferative activity; Nonsymmetrical disulfides