title: Association between IL-10 genetic variations and cervical cancer susceptibility in a Chinese population.
abstract: We conducted an investigation into the role of the IL-10 polymorphisms -592A/C (rs1800872), -819C/T (rs1800871), and -1082A/G (rs1800896) in cervical cancer risk in a Chinese population. A case-control study was carried out, including 165 newly diagnosed cervical cancer patients and 165 control subjects. The polymerase chain reaction-restriction fragment length polymorphism method was used to genotype the three IL-10 variant loci. Using conditional logistic regression analysis, we observed that homozygous IL-10 -819C/T TT carriers were at significantly increased risk of cervical cancer compared to homozygous CC individuals, with an adjusted odds ratio (OR) of 2.23 and a 95% confidence interval (CI) of 1.16-4.30. Moreover, the CT+TT genotype was significantly associated with cervical cancer in comparison to the wild-type variant (OR = 1.69, 95%CI = 1.04-2.76; P = 0.03). In conclusion, our study suggests that the IL-10 -819C/T genetic variation may contribute to cervical cancer risk in the Chinese population examined.
authors.affiliation: Department of Gynecology, Affiliated Hospital of Yanan University, Yan'an, China.
authors.forename: C Y
authors.initials: CY
authors.lastname: Bai
authors.affiliation: Department of Gynecology, Affiliated Hospital of Yanan University, Yan'an, China shuxiaoyany@163.com.
authors.forename: X Y
authors.initials: XY
authors.lastname: Shi
authors.affiliation: Department of Gynecology, Affiliated Hospital of Yanan University, Yan'an, China.
authors.forename: J
authors.initials: J
authors.lastname: He
authors.affiliation: Department of Gynecology, Affiliated Hospital of Yanan University, Yan'an, China.
authors.forename: J
authors.initials: J
authors.lastname: Xue
authors.affiliation: Department of Gynecology, Affiliated Hospital of Yanan University, Yan'an, China.
authors.forename: Y
authors.initials: Y
authors.lastname: Feng
mesh_terms: D044466:Asian People / Q000235:genetics*; D002681:China; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D016753:Interleukin-10 / Q000235:genetics*; D002583:Uterine Cervical Neoplasms / Q000235:genetics*
chemical_list: D016753:Interleukin-10