title: Comparison of the Effects of Glutamine, Curcumin, and Nesfatin-1 on the Gastric Serosal Surface Neomucosa Formation: An Experimental Rodent Model.
abstract: Introduction. Short bowel syndrome can crop up if more than 50% of small intestine is resected or when less than 100 cm of small bowel is left. Glutamine is the main food source of enterocytes. Curcumin has protective effects on intestinal ischemia-reperfusion damage. Nesfatin-1 is a satiety molecule. It has protective effects on gastric mucosa. The primary purpose of this study is to compare effects of glutamine, curcumin, and nesfatin-1 on the gastric serosal surface neomucosa formation on rats. Materials and Methods. 24 Wistar-Hannover rats were randomly divided into 4 groups and treated with saline, glutamine, curcumin, and nesfatin-1 after ileogastric anastomosis. After 14 days all rats were euthanized, and blood was collected. En bloc resection of anastomotic part was performed for histopathological examination. Results. PDGF, TGF-β, and VEGF levels and neomucosa formation were higher in glutamine group (p = 0.003, p = 0.003, and p = 0.025). Glutamine promotes the intestinal neomucosa formation on the gastric serosal surface and augments growth factors essential for neomucosa formation on rats. Conclusion. Glutamine may be used in short bowel syndrome for increasing the absorption surface area. But that needs to be determined by adequately powered clinical trials.
authors.affiliation: Department of General Surgery, Istanbul Bagcilar Training and Research Hospital, 34100 Istanbul, Turkey.
authors.forename: Osman Bilgin
authors.identifier: 0000-0001-5285-6909
authors.initials: OB
authors.lastname: Gulcicek
authors.affiliation: Department of General Surgery, Istanbul Bagcilar Training and Research Hospital, 34100 Istanbul, Turkey.
authors.forename: Ali
authors.initials: A
authors.lastname: Solmaz
authors.affiliation: Department of General Surgery, Istanbul Bagcilar Training and Research Hospital, 34100 Istanbul, Turkey.
authors.forename: Hakan
authors.initials: H
authors.lastname: Yiğitbaş
authors.affiliation: Department of General Surgery, Istanbul Bagcilar Training and Research Hospital, 34100 Istanbul, Turkey.
authors.forename: Candas
authors.identifier: 0000-0002-8857-2817
authors.initials: C
authors.lastname: Ercetin
authors.affiliation: Department of General Surgery, Istanbul Bagcilar Training and Research Hospital, 34100 Istanbul, Turkey.
authors.forename: Erkan
authors.initials: E
authors.lastname: Yavuz
authors.affiliation: Department of General Surgery, Istanbul Bagcilar Training and Research Hospital, 34100 Istanbul, Turkey.
authors.forename: Kamil
authors.initials: K
authors.lastname: Ozdogan
authors.affiliation: Department of General Surgery, Istanbul Bagcilar Training and Research Hospital, 34100 Istanbul, Turkey.
authors.forename: Sinan
authors.initials: S
authors.lastname: Arici
authors.affiliation: Department of Pathology, Istanbul Bagcilar Training and Research Hospital, 34100 Istanbul, Turkey.
authors.forename: Asli Kahraman
authors.identifier: 0000-0001-5781-8506
authors.initials: AK
authors.lastname: Akkalp
authors.affiliation: Department of Biochemistry, Istanbul Bagcilar Training and Research Hospital, 34100 Istanbul, Turkey.
authors.forename: Tulin
authors.initials: T
authors.lastname: Sarac
authors.affiliation: Department of General Surgery, Istanbul Bagcilar Training and Research Hospital, 34100 Istanbul, Turkey.
authors.forename: Fatih
authors.initials: F
authors.lastname: Çelebi
authors.affiliation: Department of General Surgery, Istanbul Bagcilar Training and Research Hospital, 34100 Istanbul, Turkey.
authors.forename: Atilla
authors.initials: A
authors.lastname: Celik