title: Are Anatomic Results Influenced by WEB Shape Modification? Analysis in a Prospective, Single-Center Series of 39 Patients with Aneurysms Treated with the WEB.
abstract: Endovascular treatment with the flow-disrupter Woven EndoBridge aneurysm embolization system (WEB) is an innovative treatment for wide-neck bifurcation aneurysms. Prospective, multicenter studies have shown the high safety of this technique. Stability of aneurysm occlusion in long-term follow-up has been rarely studied. Moreover the "compression" phenomenon has been reported and seems to be associated with poor anatomic results. This prospective, single-center series analyzes the safety and efficacy of the WEB device in long-term follow-up in relation to WEB shape modification.
  
  
  
  All patients with aneurysms treated with the WEB were prospectively included in a data base. Demographics, aneurysm characteristics, adverse events, and anatomic results were retrospectively analyzed. Anatomic results and modification of the WEB shape on the follow-up examinations were independently evaluated by a core laboratory.
  
  
  
  Thirty-nine patients were included. We observed few complications: intraoperative rupture in no patients (0.0%) and thromboembolic events in 3 patients (7.7%) with a permanent deficit in 1 (2.6%). At short-term, midterm, and long-term follow-up, adequate occlusion was obtained in 86.8%, 83.3%, and 87.5%, respectively. Retreatment rates were low (5.1%). At 6 months, WEB shape modification (compression/retraction) was observed in 31.6% of patients but was not associated with a lower rate of adequate occlusion.
  
  
  
  This prospective, single-center series with WEB devices used in 39 patients during 3.5 years confirms data from previous multicenter studies. Treatment can be accomplished with good safety and efficacy, with a high rate of adequate occlusion. Anatomic results were not worse in case of WEB shape modification.
authors.affiliation: From the Department of Neuroradiology (D.H., R.B., A.P.N., K.J.), Bretonneau Hospital, University of Tours, Tours, France denis.herbreteau@univ-tours.fr.|University François-Rabelais (D.H.), Tours, France.
authors.forename: D
authors.identifier: 0000-0002-4533-4296
authors.initials: D
authors.lastname: Herbreteau
authors.affiliation: From the Department of Neuroradiology (D.H., R.B., A.P.N., K.J.), Bretonneau Hospital, University of Tours, Tours, France.
authors.forename: R
authors.identifier: 0000-0002-5189-3676
authors.initials: R
authors.lastname: Bibi
authors.affiliation: From the Department of Neuroradiology (D.H., R.B., A.P.N., K.J.), Bretonneau Hospital, University of Tours, Tours, France.
authors.forename: A P
authors.identifier: 0000-0001-5658-1439
authors.initials: AP
authors.lastname: Narata
authors.affiliation: From the Department of Neuroradiology (D.H., R.B., A.P.N., K.J.), Bretonneau Hospital, University of Tours, Tours, France.
authors.forename: K
authors.identifier: 0000-0002-7305-3125
authors.initials: K
authors.lastname: Janot
authors.affiliation: Department of Neuroradiology (C.P.), Charles Nicole Hospital, University of Rouen, Rouen, France.
authors.forename: C
authors.identifier: 0000-0002-9473-9644
authors.initials: C
authors.lastname: Papagiannaki
authors.affiliation: Department of Neuroradiology (S.S., L.P.), Centre Hospitalier Universitaire Reims, University Reims-Champagne-Ardenne, Reims, France.
authors.forename: S
authors.identifier: 0000-0002-6893-661X
authors.initials: S
authors.lastname: Soize
authors.affiliation: Department of Neuroradiology (S.S., L.P.), Centre Hospitalier Universitaire Reims, University Reims-Champagne-Ardenne, Reims, France.
authors.forename: L
authors.identifier: 0000-0002-2523-4909
authors.initials: L
authors.lastname: Pierot
mesh_terms: D000328:Adult; D004621:Embolization, Therapeutic / Q000009:adverse effects / Q000295:instrumentation*; D057510:Endovascular Procedures / Q000009:adverse effects / Q000295:instrumentation*; D005260:Female; D006801:Humans; D002532:Intracranial Aneurysm / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000453:epidemiology; D011446:Prospective Studies; D012189:Retrospective Studies; D016896:Treatment Outcome