title: New Isocoumarins and Related Metabolites from Talaromyces flavus.
abstract: Two new isocoumarin derivatives, talaisocoumarins A (1) and B (2), and three new related metabolites, talaflavuols A-C (3-5) were isolated from the wetland soil-derived fungus Talaromyces flavus BYD07-13. Their structures were elucidated by spectroscopic (NMR) and MS analyses. The absolute configurations of 1 and 2 were determined by CD and an Rh2(OCOCF3)4-induced CD method. All compounds were evaluated for cytotoxic and antimicrobial activities. However, none of them showed any activity. The plausible biosynthetic pathways for 1-5 were also proposed.
authors.forename: Jun-Wei
authors.initials: JW
authors.lastname: He
authors.forename: Huai-Shuang
authors.initials: HS
authors.lastname: Xu
authors.forename: Li
authors.initials: L
authors.lastname: Yang
authors.forename: Wei-Wei
authors.initials: WW
authors.lastname: He
authors.forename: Chuan-Xi
authors.initials: CX
authors.lastname: Wang
authors.forename: Feng
authors.initials: F
authors.lastname: Lin
authors.forename: Yang-Yun
authors.initials: YY
authors.lastname: Lian
authors.forename: Bo-Hang
authors.initials: BH
authors.lastname: Sun
authors.forename: Guo-Yue
authors.initials: GY
authors.lastname: Zhong
mesh_terms: D000890:Anti-Infective Agents / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects / Q000254:growth & development; D005658:Fungi / Q000187:drug effects / Q000254:growth & development; D049934:Isocoumarins / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D032901:Talaromyces / Q000737:chemistry* / Q000378:metabolism
chemical_list: D000890:Anti-Infective Agents; D049934:Isocoumarins