title: New Perspectives in Glioblastoma: Nanoparticles-based Approaches.
abstract: Glioblastoma multiforme represents one of the most aggressive tumor of central nervous system. Current therapy includes surgery, radiation and chemotherapy. These treatments are rarely curative and glioma are associated with a poor prognosis. Nanomedicine represents the most innovative branch of medicine since many studies demonstrated great advantage in the diagnosis and therapy of several diseases. In this review we will summarize the results obtained by the use of nanoparticles and extracellular vesicles in glioblastoma. A great interest is raising from these studies that underlined the efficacy and specificity of this treatment for glioma, reducing side-effects associated with conventional therapies.
authors.forename: Rosa
authors.initials: R
authors.lastname: Luciano
authors.forename: Giulia
authors.initials: G
authors.lastname: Battafarano
authors.forename: Rossana
authors.initials: R
authors.lastname: Saracino
authors.forename: Michela
authors.initials: M
authors.lastname: Rossi
authors.forename: Antonio
authors.initials: A
authors.lastname: Perrotta
authors.forename: Melania
authors.initials: M
authors.lastname: Manco
authors.forename: Maurizio
authors.initials: M
authors.lastname: Muraca
authors.affiliation: Multi-Factorial Disease and Complex Phenotype Research Area, Bambino Gesu Children's Hospital, IRCCS, Viale di San Paolo 15, 00146, Rome, Italy.
authors.forename: Andrea
authors.initials: A
authors.lastname: Del Fattore
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000627:therapeutic use; D001932:Brain Neoplasms / Q000628:therapy*; D016503:Drug Delivery Systems / Q000379:methods*; D015316:Genetic Therapy / Q000379:methods; D005909:Glioblastoma / Q000628:therapy*; D006801:Humans; D007167:Immunotherapy / Q000379:methods; D008081:Liposomes / Q000008:administration & dosage / Q000737:chemistry; D058990:Molecular Targeted Therapy / Q000379:methods; D053758:Nanoparticles / Q000008:administration & dosage / Q000737:chemistry / Q000627:therapeutic use*; D057145:Nanoshells / Q000737:chemistry / Q000627:therapeutic use; D045663:Quantum Dots
chemical_list: D000970:Antineoplastic Agents; D008081:Liposomes
keywords: Glioblastoma; extracellular vesicles; nanomedicine; nanoparticles