title: Associations of Serum Manganese Levels with Prediabetes and Diabetes among ≥60-Year-Old Chinese Adults: A Population-Based Cross-Sectional Analysis.
abstract: Older adults can experience glucose metabolism dysfunction, and although manganese may help regulate glucose metabolism, there is little information regarding this association among older people. This cross-sectional study included 2402 Chinese adults who were ≥60 years old in 2013 (Tianjin, China), and evaluated the associations of serum manganese with prediabetes and diabetes. Serum manganese levels were measured using inductively coupled plasma mass spectrometry. Multivariable logistic regression models were used to evaluate the sex-specific associations of manganese levels with diabetes and prediabetes after adjusting for confounding factors (age, sex, life style factors, and health status). Based on the WHO criteria, prediabetes was observed in 15.1% of men and 13.4% of women, while diabetes was observed in 30.0% of men and 34.4% of women. In the final model, the odds ratios (95% confidence interval) for prediabetes according to manganese quartile were 1.000, 0.463 (0.269-0.798), 0.639 (0.383-1.065), and 0.614 (0.365-1.031) among men and 1.000, 0.773 (0.498-1.200), 0.602 (0.382-0.947), and 0.603 (0.381-0.953) among women (p for trend = 0.134 and 0.015, respectively). The lowest prevalence of diabetes among men occurred at a moderate range of serum manganese (p < 0.05). Therefore, appropriate serum manganese levels may help prevent and control prediabetes and diabetes.
authors.affiliation: Department of Nutrition and Food Science, School of Public Health, Tianjin Medical University, 22 Qixiangtai Road, Heping District, Tianjin 300070, China. wangxuan@tmu.edu.cn.
authors.forename: Xuan
authors.initials: X
authors.lastname: Wang
authors.affiliation: Department of Physics and Chemistry, Tianjin Centers for Disease Control and Prevention, 6 Huayue Road, Hedong District, Tianjin 300070, China. zhmyue@163.com.
authors.forename: Mingyue
authors.initials: M
authors.lastname: Zhang
authors.affiliation: Department of Physics and Chemistry, Tianjin Centers for Disease Control and Prevention, 6 Huayue Road, Hedong District, Tianjin 300070, China. lvguang2003@163.com.
authors.forename: Guang
authors.initials: G
authors.lastname: Lui
authors.affiliation: Department of Rehabilitation and Sports Medicine, Tianjin Medical University, 22 Qixiangtai Road, Heping District, Tianjin 300070, China. changhong@tmu.edu.cn.
authors.forename: Hong
authors.initials: H
authors.lastname: Chang
authors.affiliation: Department of Nutrition and Food Science, School of Public Health, Tianjin Medical University, 22 Qixiangtai Road, Heping District, Tianjin 300070, China. defjmmm@163.com.
authors.forename: Meilin
authors.initials: M
authors.lastname: Zhang
authors.affiliation: Community Health Service Center for Shuangjie Town of Beichen District in Tianjin, Zhangwan Road, Shuangjie Town, Beichen District, Tianjin 300400, China. liuweitmu@126.com.
authors.forename: Wei
authors.initials: W
authors.lastname: Liu
authors.affiliation: Department of Nutrition and Food Science, School of Public Health, Tianjin Medical University, 22 Qixiangtai Road, Heping District, Tianjin 300070, China. lzw30706sky@163.com.
authors.forename: Ziwei
authors.initials: Z
authors.lastname: Li
authors.affiliation: Department of Nutrition and Food Science, School of Public Health, Tianjin Medical University, 22 Qixiangtai Road, Heping District, Tianjin 300070, China. tjmulyx@126.com.
authors.forename: Yixin
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Department of Nutrition and Food Science, School of Public Health, Tianjin Medical University, 22 Qixiangtai Road, Heping District, Tianjin 300070, China. huangguowei@tmu.edu.cn.
authors.forename: Guowei
authors.initials: G
authors.lastname: Huang
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000208:ethnology; D001786:Blood Glucose / Q000032:analysis; D002681:China / Q000453:epidemiology; D003151:Community Health Centers; D003430:Cross-Sectional Studies; D003922:Diabetes Mellitus, Type 1 / Q000097:blood / Q000188:drug therapy / Q000453:epidemiology / Q000208:ethnology; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000188:drug therapy / Q000453:epidemiology / Q000208:ethnology; D005260:Female; D015577:Geriatric Assessment; D006801:Humans; D007004:Hypoglycemic Agents / Q000627:therapeutic use; D008297:Male; D008345:Manganese / Q000097:blood*; D008875:Middle Aged; D008954:Models, Biological; D011236:Prediabetic State / Q000097:blood* / Q000453:epidemiology / Q000208:ethnology; D015995:Prevalence; D012307:Risk Factors; D057566:Self Report; D012737:Sex Factors
chemical_list: D001786:Blood Glucose; D007004:Hypoglycemic Agents; D008345:Manganese
keywords: diabetes; manganese; older adult; prediabetes