title: [REVIEW OF 30 YEARS OF RESEARCH AND DEVELOPMENT OF AN ENZYMATIC DEBRIDEMENT AGENT FOR BURNS].
abstract: BACKGROUND
  Early removal of burn eschar is a cornerstone of burn care. The most commonly practiced eschar removal technique for deep burns in modern burn care is surgical debridement but this technique is associated with surgical burden and leads to unnecessary excision of viable tissue.
  
  
  OBJECTIVE
  To review 30 years of research and development of an enzymatic debridement agent for burns.
  
  
  METHODS
  Studies performed during the last 30 years are reviewed in this manuscript.
  
  
  RESULTS
  Patients who underwent enzymatic debridement had a significantly shorter time to complete debridement, the surgical burden was significantly lower, hand burns did not necessitate escharotomy, and the long term results were favorable.
  
  
  CONCLUSIONS
  Early enzymatic debridement leads to an efficient debridement, preservation of viable tissue, a reduction in surgical burden and favorable long term results.
  
  
  CONCLUSIONS
  We believe early enzymatic debridement will lead to better care for burn victims and perhaps, even to a paradigm shift in the treatment of burns.
authors.forename: Yuval
authors.initials: Y
authors.lastname: Krieger
authors.forename: Yaron
authors.initials: Y
authors.lastname: Shoham
authors.forename: Alexander
authors.initials: A
authors.lastname: Bogdanov-Berezovsky
authors.forename: Eldad
authors.initials: E
authors.lastname: Silberstein
authors.forename: Amiram
authors.initials: A
authors.lastname: Sagi
authors.forename: Avraham
authors.initials: A
authors.lastname: Levy
authors.forename: Nir
authors.initials: N
authors.lastname: Rosenberg
authors.forename: Guy
authors.initials: G
authors.lastname: Rubin
authors.forename: Dana
authors.initials: D
authors.lastname: Egozi
authors.forename: Yehuda
authors.initials: Y
authors.lastname: Ullman
authors.forename: Josef
authors.initials: J
authors.lastname: Haik
authors.forename: Lior
authors.initials: L
authors.lastname: Rosenberg
mesh_terms: D001963:Bromelains / Q000008:administration & dosage*; D002056:Burns / Q000175:diagnosis / Q000503:physiopathology / Q000628:therapy*; D002986:Clinical Trials as Topic; D003646:Debridement / Q000379:methods*; D003879:Dermatologic Agents / Q000008:administration & dosage; D055808:Drug Discovery; D005260:Female; D006801:Humans; D007557:Israel; D008297:Male; D010043:Outcome and Process Assessment, Health Care; D015599:Trauma Severity Indices; D014945:Wound Healing / Q000187:drug effects*
chemical_list: D003879:Dermatologic Agents; D001963:Bromelains