title: Chinese herbal medicine, Jianpi Ligan decoction, improves prognosis of unresectable hepatocellular carcinoma after transarterial chemoembolization: a retrospective study.
abstract: OBJECTIVE
  This study aimed to investigate the efficacy of Jianpi Ligan decoction (JLD) as an adjuvant therapy for patients with unresectable hepatocellular carcinoma (HCC) treated by transarterial chemoembolization (TACE).
  
  
  METHODS
  From March 2007 to March 2013, 103 patients with unresectable HCC who underwent TACE in our center were included in this retrospective study. Among the 103 patients, 53 patients accepted JLD along with TACE (JLD group) and 50 patients accepted TACE alone (control group). Indices including complication, toxicity, treatment success rate, and long-term survival were obtained for analysis and comparison.
  
  
  RESULTS
  There was no significant difference in patient characteristics between the two groups. No procedure-related deaths or encephalopathy occurred. Fewer patients from the JLD group experienced constipation (7/53 vs 15/50, P=0.0377), abdominal bloating (5/53 vs 12/50, P=0.0466), and lack of appetite (35/53 vs 42/50, P=0.0360). The JLD group had lesser and lighter hepatic toxicity (P=0.0265) and gastrointestinal toxicity (P=0.0445) such as nausea and vomiting. The JLD group had a significantly higher treatment success rate than the control group (51/53 vs 40/50, P=0.0103). Three-year overall survival probability was significantly higher in the JLD group than in the control group (37.74% vs 26.00%; hazard ratio [HR] 0.6171; 95% confidence interval [CI], 0.3832-0.9938; P=0.0365 by log-rank test). No significant difference was found in 3-year overall survival probability (39.22% vs 32.50%; HR, 0.7449; 95% CI, 0.4398-1.2614; P=0.2491 by log-rank test) or 3-year intrahepatic recurrence-free survival probability in patients who achieved treatment success (37.25% vs 30.00%; HR, 0.7280; 95% CI, 0.4332-1.2233; P=0.2087 by log-rank test) between the two groups.
  
  
  CONCLUSIONS
  Application of JLD was effective for reduction of side effects and improvement of long-term survival for patients with unresectable HCC treated by TACE.
authors.affiliation: Department of General Surgery.
authors.forename: Cheng Wu
authors.initials: CW
authors.lastname: Tang
authors.affiliation: Department of Nephrology.
authors.forename: Ming
authors.initials: M
authors.lastname: Zhu
authors.affiliation: Department of General Surgery.
authors.forename: Wen Ming
authors.initials: WM
authors.lastname: Feng
authors.affiliation: Department of General Surgery.
authors.forename: Ying
authors.initials: Y
authors.lastname: Bao
authors.affiliation: Department of Radiology, First People's Hospital Affiliated to Huzhou University Medical College, Huzhou, People's Republic of China.
authors.forename: Yin Yuan
authors.initials: YY
authors.lastname: Zheng
mesh_terms: D006528:Carcinoma, Hepatocellular / Q000188:drug therapy*; D016461:Chemoembolization, Therapeutic; D004365:Drugs, Chinese Herbal / Q000494:pharmacology* / Q000627:therapeutic use*; D006801:Humans; D008113:Liver Neoplasms / Q000188:drug therapy*; D011379:Prognosis; D016016:Proportional Hazards Models; D012189:Retrospective Studies; D015996:Survival Rate; D016896:Treatment Outcome
chemical_list: D004365:Drugs, Chinese Herbal; C000616771:Jianpi Ligan decoction
keywords: hepatocellular carcinoma; overall survival; traditional Chinese medicine; transarterial chemoembolization