title: STARs in the CNS.
abstract: STAR (signal transduction and activation of RNA) proteins regulate splicing of target genes that have roles in neural connectivity, survival and myelination in the vertebrate nervous system. These regulated splicing targets include mRNAs such as the Neurexins (Nrxn), SMN2 (survival of motor neuron) and MAG (myelin-associated glycoprotein). Recent work has made it possible to identify and validate STAR protein splicing targets in vivo by using genetically modified mouse models. In this review, we will discuss the importance of STAR protein splicing targets in the CNS (central nervous system).
authors.affiliation: Institute of Genetic Medicine, Newcastle University, Central Parkway, Newcastle NE1 3BZ, U.K. ingrid.ehrmann@ncl.ac.uk.
authors.forename: Ingrid
authors.initials: I
authors.lastname: Ehrmann
authors.affiliation: Université Montpellier, UMR 5237, Centre de Recherche de Biologie Cellulaire de Montpellier, CNRS, Montpellier, France.
authors.forename: Philippe
authors.initials: P
authors.lastname: Fort
authors.affiliation: Institute of Genetic Medicine, Newcastle University, Central Parkway, Newcastle NE1 3BZ, U.K.
authors.forename: David J
authors.initials: DJ
authors.lastname: Elliott
mesh_terms: D000818:Animals; D002135:Calcium-Binding Proteins; D015816:Cell Adhesion Molecules, Neuronal / Q000235:genetics; D002490:Central Nervous System / Q000378:metabolism*; D006801:Humans; D018992:Myelin-Associated Glycoprotein / Q000235:genetics; D009419:Nerve Tissue Proteins / Q000235:genetics; D019006:Neural Cell Adhesion Molecules; D010802:Phylogeny; D012326:RNA Splicing; D012333:RNA, Messenger / Q000235:genetics* / Q000378:metabolism; D016601:RNA-Binding Proteins / Q000145:classification / Q000235:genetics* / Q000378:metabolism; D055540:Survival of Motor Neuron 2 Protein / Q000235:genetics
chemical_list: D002135:Calcium-Binding Proteins; D015816:Cell Adhesion Molecules, Neuronal; D018992:Myelin-Associated Glycoprotein; C539628:NRXN1 protein, human; D009419:Nerve Tissue Proteins; D019006:Neural Cell Adhesion Molecules; D012333:RNA, Messenger; D016601:RNA-Binding Proteins; C526477:SMN2 protein, human; D055540:Survival of Motor Neuron 2 Protein
keywords: CNS (central nervous system); KHDRBS (KH domain RNA binding and signal transduction); RNA-binding proteins; STAR (signal transduction and activation of RNA); alternative splicing; neurexin