title: Relation of serum irisin level with metabolic and antropometric parameters in obese children.
abstract: This study aimed to investigate the relationship between serum irisin level and metabolic and anthropometric parameters in obese children.
  
  
  
  The study included 36 obese children with a body mass index (BMI) of ≥95th percentile and 30 healthy children with a BMI ranging from the 5th to the 85th percentile. Healthy and obese children had similar age, gender and pubertal stage distribution. Anthropometric and biochemical parameters (fasting glucose, insulin, lipid profile, leptin and irisin levels) were measured. Bioelectric impedance analysis was used to determine the body composition parameters, including body fat percentage and fat mass.
  
  
  
  Serum irisin and leptin levels of the obese children were significantly higher than those of the healthy children [median irisin levels, 141.2 & 107.6ng/mL, p=0.024; median leptin levels, 10.9 & 2.9pg/mL, P<0.001, respectively). No statistically significant difference was found when leptin and irisin levels were compared among obese patients in terms of the presence of insulin resistance. Irisin levels significantly correlated with high-density lipoprotein cholesterol (HDL-C), fasting insulin and homeostasis model assessment-insulin resistance (HOMA-IR) with adjustment for age and BMI. The multivariate regression analysis showed that age, HOMA-IR and HDL-C had a significant association with the serum irisin level, which explained 30.6% of the variance.
  
  
  
  This study demonstrated that obese children had significantly higher irisin levels than healthy children. Additionally, it provides evidence regarding the role of irisin on insulin sensitivity and lipid metabolism in childhood obesity.
authors.affiliation: Department of Pediatric Endocrinology, Katip Celebi University, Faculty of Medicine, Izmir. Electronic address: gonulcatli@gmail.com.
authors.forename: Gönül
authors.initials: G
authors.lastname: Çatlı
authors.affiliation: Department of Biochemistry, Dokuz Eylul University, Faculty of Medicine, Izmir.
authors.forename: Tuncay
authors.initials: T
authors.lastname: Küme
authors.affiliation: Department of Pediatric Endocrinology, Dokuz Eylul University, Faculty of Medicine, Izmir.
authors.forename: Hale Ünver
authors.initials: HÜ
authors.lastname: Tuhan
authors.affiliation: Department of Pediatric Endocrinology, Adnan Menderes University, Faculty of Medicine, Aydın.
authors.forename: Ahmet
authors.initials: A
authors.lastname: Anık
authors.affiliation: Department of Biochemistry, Dokuz Eylul University, Faculty of Medicine, Izmir.
authors.forename: Özlem Gürsoy
authors.initials: ÖG
authors.lastname: Çalan
authors.affiliation: Department of Pediatric Endocrinology, Dokuz Eylul University, Faculty of Medicine, Izmir.
authors.forename: Ece
authors.initials: E
authors.lastname: Böber
authors.affiliation: Department of Pediatric Endocrinology, Dokuz Eylul University, Faculty of Medicine, Izmir.
authors.forename: Ayhan
authors.initials: A
authors.lastname: Abacı
mesh_terms: D000293:Adolescent; D000886:Anthropometry; D001786:Blood Glucose / Q000032:analysis; D015992:Body Mass Index; D016022:Case-Control Studies; D002648:Child; D008076:Cholesterol, HDL / Q000097:blood; D005260:Female; D005353:Fibronectins / Q000097:blood*; D006801:Humans; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D020738:Leptin / Q000097:blood; D050356:Lipid Metabolism; D008297:Male; D009765:Obesity / Q000097:blood* / Q000378:metabolism
chemical_list: D001786:Blood Glucose; D008076:Cholesterol, HDL; C577593:FNDC5 protein, human; D005353:Fibronectins; D007328:Insulin; D020738:Leptin
keywords: Children; Fat mass; Insulin resistance; Irisin; Leptin; Obesity