title: In vitro ceftaroline combinations against meticillin-resistant Staphylococcus aureus.
abstract: We studied in vitro ceftaroline combinations against 61 meticillin-resistant Staphylococcus aureus isolates; 18 of them were also resistant to linezolid, using overlapping E-test method. Daptomycin-ceftaroline combination obtained lower fractional inhibitory concentration values, in comparison with those including vancomycin or linezolid against meticillin-resistant S. aureus (P<0.05). All meticillin- and linezolid-resistant S. aureus strains were resistant to ceftaroline; nevertheless, combinations with vancomycin or daptomycin showed higher synergy or addition rates than those with linezolid.
authors.affiliation: Department of Clinical Microbiology and Infectious Diseases, Hospital Clinico San Carlos, Universidad Complutense, Madrid, Spain.
authors.forename: Ana Belén
authors.initials: AB
authors.lastname: García
authors.affiliation: Department of Clinical Microbiology and Infectious Diseases, Hospital Clinico San Carlos, Universidad Complutense, Madrid, Spain.
authors.forename: Francisco Javier
authors.initials: FJ
authors.lastname: Candel
authors.affiliation: Department of Clinical Microbiology and Infectious Diseases, Hospital Clinico San Carlos, Universidad Complutense, Madrid, Spain.
authors.forename: Laura
authors.initials: L
authors.lastname: López
authors.affiliation: Department of Clinical Microbiology and Infectious Diseases, Hospital Clinico San Carlos, Universidad Complutense, Madrid, Spain.
authors.forename: Flavia
authors.initials: F
authors.lastname: Chiarella
authors.affiliation: Department of Clinical Microbiology and Infectious Diseases, Hospital Clinico San Carlos, Universidad Complutense, Madrid, Spain.
authors.forename: José Manuel
authors.initials: JM
authors.lastname: Viñuela-Prieto
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002511:Cephalosporins / Q000494:pharmacology*; D017576:Daptomycin / Q000494:pharmacology; D004359:Drug Therapy, Combination; D006801:Humans; D000069349:Linezolid / Q000494:pharmacology; D008712:Methicillin / Q000494:pharmacology; D055624:Methicillin-Resistant Staphylococcus aureus / Q000187:drug effects* / Q000235:genetics / Q000302:isolation & purification; D008826:Microbial Sensitivity Tests; D013203:Staphylococcal Infections / Q000188:drug therapy / Q000382:microbiology*; D014640:Vancomycin / Q000494:pharmacology; D000097583:Ceftaroline
chemical_list: D000900:Anti-Bacterial Agents; D002511:Cephalosporins; D017576:Daptomycin; D000069349:Linezolid; D008712:Methicillin; D014640:Vancomycin; D000097583:Ceftaroline