title: Development of a Rational Design Space for Optimizing Mixing Conditions for Formation of Adhesive Mixtures for Dry-Powder Inhaler Formulations.
abstract: The purpose of the present study was to develop guidance toward rational choice of blenders and processing conditions to make robust and high performing adhesive mixtures for dry-powder inhalers and to develop quantitative experimental approaches for optimizing the process. Mixing behavior of carrier (LH100) and AstraZeneca fine lactose in high-shear and low-shear double cone blenders was systematically investigated. Process variables impacting the mixing performance were evaluated for both blenders. The performance of the blenders with respect to the mixing time, press-on forces, static charging, and abrasion of carrier fines was monitored, and for some of the parameters, distinct differences could be detected. A comparison table is presented, which can be used as a guidance to enable rational choice of blender and process parameters based on the user requirements. Segregation of adhesive mixtures during hopper discharge was also investigated.
authors.affiliation: Department of Pharmaceutical Sciences, University of Connecticut, Storrs, Connecticut 06269.
authors.forename: Saurabh
authors.initials: S
authors.lastname: Sarkar
authors.affiliation: Department of Pharmaceutical Sciences, University of Connecticut, Storrs, Connecticut 06269.
authors.forename: Bruna
authors.initials: B
authors.lastname: Minatovicz
authors.affiliation: Research & Development, Astra Zeneca, Mölndal, Sweden.
authors.forename: Kyrre
authors.initials: K
authors.lastname: Thalberg
authors.affiliation: Department of Pharmaceutical Sciences, University of Connecticut, Storrs, Connecticut 06269; Institute of Material Sciences, University of Connecticut, Storrs, Connecticut 06269. Electronic address: bodhi.chaudhuri@uconn.edu.
authors.forename: Bodhisattwa
authors.initials: B
authors.lastname: Chaudhuri
mesh_terms: D000269:Adhesives / Q000737:chemistry*; D000280:Administration, Inhalation; D002626:Chemistry, Pharmaceutical / Q000379:methods; D004337:Drug Carriers / Q000737:chemistry*; D058995:Dry Powder Inhalers / Q000379:methods*; D006801:Humans; D007785:Lactose / Q000737:chemistry*; D010316:Particle Size; D011208:Powders
chemical_list: D000269:Adhesives; D004337:Drug Carriers; D011208:Powders; D007785:Lactose
keywords: abrasion; adhesive mixtures; dry-powder inhalers; mixing; press-on forces; pulmonary drug delivery