title: Retinotopic patterns of functional connectivity between V1 and large-scale brain networks during resting fixation.
abstract: Psychophysical and neurobiological evidence suggests that central and peripheral vision are specialized for different functions. This specialization of function might be expected to lead to differences in the large-scale functional interactions of early cortical areas that represent central and peripheral visual space. Here, we characterize differences in whole-brain functional connectivity among sectors in primary visual cortex (V1) corresponding to central, near-peripheral, and far-peripheral vision during resting fixation. Importantly, our analyses reveal that eccentricity sectors in V1 have different functional connectivity with non-visual areas associated with large-scale brain networks. Regions associated with the fronto-parietal control network are most strongly connected with central sectors of V1, regions associated with the cingulo-opercular control network are most strongly connected with near-peripheral sectors of V1, and regions associated with the default mode and auditory networks are most strongly connected with far-peripheral sectors of V1. Additional analyses suggest that similar patterns are present during eyes-closed rest. These results suggest that different types of visual information may be prioritized by large-scale brain networks with distinct functional profiles, and provide insights into how the small-scale functional specialization within early visual regions such as V1 relates to the large-scale organization of functionally distinct whole-brain networks.
authors.affiliation: Department of Psychology, University of Alabama at Birmingham, United States.
authors.forename: Joseph C
authors.initials: JC
authors.lastname: Griffis
authors.affiliation: Department of Neurobiology, University of Alabama at Birmingham, United States.
authors.forename: Abdurahman S
authors.initials: AS
authors.lastname: Elkhetali
authors.affiliation: Department of Psychology, University of Alabama at Birmingham, United States.
authors.forename: Wesley K
authors.initials: WK
authors.lastname: Burge
authors.affiliation: Department of Neurobiology, University of Alabama at Birmingham, United States.
authors.forename: Richard H
authors.initials: RH
authors.lastname: Chen
authors.affiliation: Department of Biomedical Engineering, University of Alabama at Birmingham, United States.
authors.forename: Anthony D
authors.initials: AD
authors.lastname: Bowman
authors.affiliation: Department of Neurology, University of Alabama at Birmingham, United States.
authors.forename: Jerzy P
authors.initials: JP
authors.lastname: Szaflarski
authors.affiliation: Department of Neurobiology, University of Alabama at Birmingham, United States. Electronic address: kmv@uab.edu.
authors.forename: Kristina M
authors.initials: KM
authors.lastname: Visscher
mesh_terms: D000328:Adult; D001921:Brain / Q000502:physiology*; D001931:Brain Mapping; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D009434:Neural Pathways / Q000502:physiology; D010775:Photic Stimulation; D014793:Visual Cortex / Q000502:physiology*; D014795:Visual Pathways / Q000502:physiology; D014796:Visual Perception / Q000502:physiology*; D055815:Young Adult
keywords: Attention; Eccentricity; Primary visual cortex; Top-down control; fMRI