title: Post-Intake of S-Ethyl Cysteine and S-Methyl Cysteine Improved LPS-Induced Acute Lung Injury in Mice.
abstract: The effects of S-ethyl cysteine (SEC) and S-methyl cysteine (SMC) on lipopolysaccharide (LPS)-induced acute lung injury in mice were examined. Eight hours after LPS challenge, SEC or SMC was supplied in drinking water at 0.5% or 1% for 3 days. LPS increased lung myeloperoxidase activity, neutrophil counts and edema. SEC or SMC post-intake attenuated these events. SEC or SMC suppressed LPS-induced lung expression of cyclooxygenase-2, nuclear factor-κB and mitogen-activated protein kinase, and lowered the generation of tumor necrosis factor-alpha, monocyte chemoattractant protein-1 and prostaglandin E₂. LPS enhanced the expression of p47(phox), gp91(phox), Bax and cleaved caspase-3, and increased the production of reactive oxygen species in the lung. SEC or SMC post-intake reversed these alterations. These findings suggest that these agents could protect the lung through their anti-inflammatory, anti-oxidative and anti-apoptotic activities.
authors.affiliation: Department of Respiratory Therapy, China Medical University, Taichung City 40402, Taiwan. derrick.hsia@msa.hinet.net.|Department of Internal Medicine, China Medical University Hospital, Taichung City 40402, Taiwan. derrick.hsia@msa.hinet.net.
authors.forename: Te-Chun
authors.initials: TC
authors.lastname: Hsia
authors.affiliation: Department of Nutrition, China Medical University, 91, Hsueh-shih Rd., Taichung City 40402, Taiwan. mcyin@mail.cmu.edu.tw.|Department of Health and Nutrition Biotechnology, Asia University, Taichung City 41354, Taiwan. mcyin@mail.cmu.edu.tw.
authors.forename: Mei-Chin
authors.initials: MC
authors.lastname: Yin
mesh_terms: D055371:Acute Lung Injury / Q000139:chemically induced / Q000188:drug therapy*; D000818:Animals; D003545:Cysteine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology; D005786:Gene Expression Regulation / Q000187:drug effects; D008070:Lipopolysaccharides / Q000633:toxicity*; D008168:Lung / Q000201:enzymology; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D009195:Peroxidase / Q000378:metabolism
chemical_list: D008070:Lipopolysaccharides; C008425:S-methylcysteine; C026826:S-ethylcysteine; D009195:Peroxidase; D003545:Cysteine
keywords: LPS; S-ethyl cysteine; S-methyl cysteine; inflammation; lung