title: Long-term outcomes of resection in patients with symptomatic benign liver tumours.
abstract: Benign liver tumours (e.g., hepatocellular adenoma (HCA), focal nodular hyperplasia (FNH), and haemangioma) are occasionally resected for alleged symptoms, although data on long-term outcomes is lacking. The aim of this cross-sectional study was to assess long-term outcomes of surgical intervention.
  
  
  
  Forty patients with benign tumours (HCA 20, FNH 12, giant haemangioma 4, cysts 4) were included. Patients filled in Validated McGill Pain Questionnaires, preoperatively and after a median of 54 months after resection. Outcomes were evaluated using paired sample t-test and (M) ANOVA.
  
  
  
  Relief of symptoms sustained in 30/40 patients, within a follow-up of 54 (24-148) months after resection. VAS scores were reduced from 5.5 preoperatively to 1.6 postoperatively (p < 0.001). Patients with left-sided tumours had higher postoperative Pain Rating Index (PRI), compared to patients with right-sided tumours: 15.3 vs. 5.8 (p = 0.018). If patients could reconsider undergoing surgery, 34/38 would again choose resection. Discomfort at the operative scar was the most common complaint: 8/40 patients, all after open surgery, of whom 3/40 had an incisional hernia. 7/40 patients had a laparoscopic resection.
  
  
  
  Resection relieved symptoms in 30/40 patients. The operative scar was a frequent source for remaining postoperative complaints, suggesting an advantage for a laparoscopic approach when feasible.
authors.affiliation: Department of Surgery, Academic Medical Centre, Amsterdam, The Netherlands. Electronic address: b.v.vanrosmalen@amc.uva.nl.
authors.forename: Belle V
authors.initials: BV
authors.lastname: van Rosmalen
authors.affiliation: Department of Surgery, Academic Medical Centre, Amsterdam, The Netherlands.
authors.forename: Matthanja
authors.initials: M
authors.lastname: Bieze
authors.affiliation: Department of Surgery, Academic Medical Centre, Amsterdam, The Netherlands.
authors.forename: Marc G H
authors.initials: MG
authors.lastname: Besselink
authors.affiliation: Department of Surgery, Academic Medical Centre, Amsterdam, The Netherlands.
authors.forename: Pieter
authors.initials: P
authors.lastname: Tanis
authors.affiliation: Department of Pathology, Academic Medical Centre, Amsterdam, The Netherlands.
authors.forename: Joanne
authors.initials: J
authors.lastname: Verheij
authors.affiliation: Department of Radiology, Academic Medical Centre, Amsterdam, The Netherlands.
authors.forename: Saffire S K S
authors.initials: SS
authors.lastname: Phoa
authors.affiliation: Department of Surgery, Academic Medical Centre, Amsterdam, The Netherlands.
authors.forename: Olivier
authors.initials: O
authors.lastname: Busch
authors.affiliation: Department of Surgery, Academic Medical Centre, Amsterdam, The Netherlands. Electronic address: t.m.vangulik@amc.nl.
authors.forename: Thomas M
authors.initials: TM
authors.lastname: van Gulik
mesh_terms: D018248:Adenoma, Liver Cell / Q000473:pathology / Q000601:surgery*; D000328:Adult; D000368:Aged; D002921:Cicatrix / Q000209:etiology; D003430:Cross-Sectional Studies; D005260:Female; D020518:Focal Nodular Hyperplasia / Q000473:pathology / Q000601:surgery*; D006391:Hemangioma / Q000473:pathology / Q000601:surgery*; D006498:Hepatectomy / Q000009:adverse effects; D006801:Humans; D000069290:Incisional Hernia / Q000209:etiology; D008113:Liver Neoplasms / Q000473:pathology / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D010147:Pain Measurement; D010149:Postoperative Pain / Q000175:diagnosis / Q000209:etiology; D017060:Patient Satisfaction; D013997:Time Factors; D016896:Treatment Outcome