title: The detection of multiple illicit street drugs in liquid samples by direct analysis in real time (DART) coupled to Q-orbitrap tandem mass spectrometry.
abstract: Direct analysis in real time coupled to Q-orbitrap tandem mass spectrometry (DART-MS) without requiring preparatory procedures was used to directly detect trace amounts of illegal street drugs, namely p-chloroamphetamine, p-fluoromethamphetamine, γ-hydroxybutyrate, ketamine, methamphetamine, 3,4-methylenedioxypyrovalerone, p-methylethcathinone, methylone, and nimetazepam, in solution and also in real drug samples. Exact mass determination of the drug samples was completed in less than 1min. With the ability to rapidly identify drugs, this technique shows great potential as a useful analytical tool in the analysis of illicit street drugs, and has the significant advantages of simplicity and sensitivity without the sample preparation needed by other methods.
authors.affiliation: Department of Applied Chemistry, National Chiao Tung University, Hsinchu, Taiwan.
authors.forename: Tai-Hung
authors.initials: TH
authors.lastname: Chen
authors.affiliation: Department of Applied Chemistry, National Chiao Tung University, Hsinchu, Taiwan.
authors.forename: Hsin-Yun
authors.initials: HY
authors.lastname: Hsu
authors.affiliation: Department of Applied Chemistry, National Chiao Tung University, Hsinchu, Taiwan. Electronic address: spwu@mail.nctu.edu.tw.
authors.forename: Shu-Pao
authors.initials: SP
authors.lastname: Wu
mesh_terms: D015107:4-Butyrolactone / Q000032:analysis; D000662:Amphetamines / Q000032:analysis; D001628:Beverages; D002849:Chromatography, Gas; D006801:Humans; D013287:Illicit Drugs / Q000032:analysis*; D007649:Ketamine / Q000032:analysis; D008694:Methamphetamine / Q000031:analogs & derivatives / Q000032:analysis; D009567:Nitrazepam / Q000031:analogs & derivatives / Q000032:analysis; D012978:Sodium Oxybate / Q000032:analysis; D053719:Tandem Mass Spectrometry / Q000379:methods*
chemical_list: D000662:Amphetamines; D013287:Illicit Drugs; D008694:Methamphetamine; C002714:nimetazepam; D007649:Ketamine; D012978:Sodium Oxybate; D009567:Nitrazepam; C400939:methylone; D015107:4-Butyrolactone
keywords: DART-MS; GC/MS; Liquid illicit drugs; Rapid drug screening