title: Crowdsourced assessment of common genetic contribution to predicting anti-TNF treatment response in rheumatoid arthritis.
abstract: Rheumatoid arthritis (RA) affects millions world-wide. While anti-TNF treatment is widely used to reduce disease progression, treatment fails in ∼one-third of patients. No biomarker currently exists that identifies non-responders before treatment. A rigorous community-based assessment of the utility of SNP data for predicting anti-TNF treatment efficacy in RA patients was performed in the context of a DREAM Challenge (http://www.synapse.org/RA_Challenge). An open challenge framework enabled the comparative evaluation of predictions developed by 73 research groups using the most comprehensive available data and covering a wide range of state-of-the-art modelling methodologies. Despite a significant genetic heritability estimate of treatment non-response trait (h(2)=0.18, P value=0.02), no significant genetic contribution to prediction accuracy is observed. Results formally confirm the expectations of the rheumatology community that SNP information does not significantly improve predictive performance relative to standard clinical traits, thereby justifying a refocusing of future efforts on collection of other data.
authors.affiliation: Sage Bionetworks, Seattle, Washington 98115, USA.
authors.forename: Solveig K
authors.initials: SK
authors.lastname: Sieberts
authors.affiliation: Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan 48109, USA.
authors.forename: Fan
authors.initials: F
authors.lastname: Zhu
authors.affiliation: Structural Bioinformatics Group (GRIB/IMIM), Departament de Ciències Experimentals i de la Salut, Universitat Pompeu Fabra, Barcelona 08003, Spain.
authors.forename: Javier
authors.initials: J
authors.lastname: García-García
authors.affiliation: Center for Statistical Genetics, Division of Psychiatric Genomics, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.|Icahn Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.
authors.forename: Eli
authors.initials: E
authors.lastname: Stahl
authors.affiliation: Sage Bionetworks, Seattle, Washington 98115, USA.
authors.forename: Abhishek
authors.initials: A
authors.lastname: Pratap
authors.affiliation: Icahn Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.|Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.
authors.forename: Gaurav
authors.identifier: http://orcid.org/0000-0003-1939-679X
authors.initials: G
authors.lastname: Pandey
authors.affiliation: Division of Rheumatology, Department of Medicine, Columbia University, New York, New York 10032, USA.|Corrona LLC, Southborough, Massachusetts 01772, USA.
authors.forename: Dimitrios
authors.initials: D
authors.lastname: Pappas
authors.affiliation: Structural Bioinformatics Group (GRIB/IMIM), Departament de Ciències Experimentals i de la Salut, Universitat Pompeu Fabra, Barcelona 08003, Spain.
authors.forename: Daniel
authors.initials: D
authors.lastname: Aguilar
authors.affiliation: Structural Bioinformatics Group (GRIB/IMIM), Departament de Ciències Experimentals i de la Salut, Universitat Pompeu Fabra, Barcelona 08003, Spain.
authors.forename: Bernat
authors.initials: B
authors.lastname: Anton
authors.affiliation: Structural Bioinformatics Group (GRIB/IMIM), Departament de Ciències Experimentals i de la Salut, Universitat Pompeu Fabra, Barcelona 08003, Spain.
authors.forename: Jaume
authors.identifier: http://orcid.org/0000-0001-5210-4387
authors.initials: J
authors.lastname: Bonet
authors.affiliation: Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan 48109, USA.
authors.forename: Ridvan
authors.initials: R
authors.lastname: Eksi
authors.affiliation: Structural Bioinformatics Group (GRIB/IMIM), Departament de Ciències Experimentals i de la Salut, Universitat Pompeu Fabra, Barcelona 08003, Spain.
authors.forename: Oriol
authors.initials: O
authors.lastname: Fornés
authors.affiliation: Center for Complex Network Research, Northeastern University, Boston, Massachusetts 02115, USA.
authors.forename: Emre
authors.initials: E
authors.lastname: Guney
authors.affiliation: Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan 48109, USA.
authors.forename: Hongdong
authors.initials: H
authors.lastname: Li
authors.affiliation: Structural Bioinformatics Group (GRIB/IMIM), Departament de Ciències Experimentals i de la Salut, Universitat Pompeu Fabra, Barcelona 08003, Spain.
authors.forename: Manuel Alejandro
authors.initials: MA
authors.lastname: Marín
authors.affiliation: Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan 48109, USA.
authors.forename: Bharat
authors.initials: B
authors.lastname: Panwar
authors.affiliation: Structural Bioinformatics Group (GRIB/IMIM), Departament de Ciències Experimentals i de la Salut, Universitat Pompeu Fabra, Barcelona 08003, Spain.
authors.forename: Joan
authors.initials: J
authors.lastname: Planas-Iglesias
authors.affiliation: Structural Bioinformatics Group (GRIB/IMIM), Departament de Ciències Experimentals i de la Salut, Universitat Pompeu Fabra, Barcelona 08003, Spain.
authors.forename: Daniel
authors.initials: D
authors.lastname: Poglayen
authors.affiliation: Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA.
authors.forename: Jing
authors.initials: J
authors.lastname: Cui
authors.affiliation: Department of Informatics, Faculty of Sciences, University of Lisbon, Lisbon 1749-016, Portugal.
authors.forename: Andre O
authors.initials: AO
authors.lastname: Falcao
authors.affiliation: Sage Bionetworks, Seattle, Washington 98115, USA.
authors.forename: Christine
authors.identifier: http://orcid.org/0000-0002-2986-385X
authors.initials: C
authors.lastname: Suver
authors.affiliation: Sage Bionetworks, Seattle, Washington 98115, USA.
authors.forename: Bruce
authors.identifier: http://orcid.org/0000-0002-4629-2091
authors.initials: B
authors.lastname: Hoff
authors.affiliation: IBM T.J. Watson Research Center, Yorktown Heights, New York, New York 10598, USA.
authors.forename: Venkat S K
authors.initials: VSK
authors.lastname: Balagurusamy
authors.affiliation: IBM T.J. Watson Research Center, Yorktown Heights, New York, New York 10598, USA.
authors.forename: Donna
authors.initials: D
authors.lastname: Dillenberger
authors.affiliation: Sage Bionetworks, Seattle, Washington 98115, USA.
authors.forename: Elias Chaibub
authors.initials: EC
authors.lastname: Neto
authors.affiliation: Sage Bionetworks, Seattle, Washington 98115, USA.
authors.forename: Thea
authors.initials: T
authors.lastname: Norman
authors.affiliation: IBM T.J. Watson Research Center, Yorktown Heights, New York, New York 10598, USA.
authors.forename: Tero
authors.initials: T
authors.lastname: Aittokallio
authors.affiliation: Department of Computer Science, Aalto University, Espoo 02150, Finland.|Helsinki Institute for Information Technology (HIIT), Esbo 02150, Finland.
authors.forename: Muhammad
authors.initials: M
authors.lastname: Ammad-Ud-Din
authors.affiliation: MINES ParisTech, PSL-Research University, CBIO-Centre for Computational Biology, Fontainebleau 77300, France.|Institut Curie, Paris 75248, France.|Bioinformatics, Biostatistics, Epidemiology and Computational Systems Biology of Cancer, INSERM U900, Paris 75248, France.
authors.forename: Chloe-Agathe
authors.identifier: http://orcid.org/0000-0003-1003-301X
authors.initials: CA
authors.lastname: Azencott
authors.affiliation: MINES ParisTech, PSL-Research University, CBIO-Centre for Computational Biology, Fontainebleau 77300, France.|Institut Curie, Paris 75248, France.|Bioinformatics, Biostatistics, Epidemiology and Computational Systems Biology of Cancer, INSERM U900, Paris 75248, France.
authors.forename: Víctor
authors.initials: V
authors.lastname: Bellón
authors.affiliation: MINES ParisTech, PSL-Research University, CBIO-Centre for Computational Biology, Fontainebleau 77300, France.|Institut Curie, Paris 75248, France.|Bioinformatics, Biostatistics, Epidemiology and Computational Systems Biology of Cancer, INSERM U900, Paris 75248, France.
authors.forename: Valentina
authors.initials: V
authors.lastname: Boeva
authors.affiliation: Department of Computer Science, Aalto University, Espoo 02150, Finland.|Helsinki Institute for Information Technology (HIIT), Esbo 02150, Finland.
authors.forename: Kerstin
authors.initials: K
authors.lastname: Bunte
authors.affiliation: Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki FI-00014, Finland.
authors.forename: Himanshu
authors.initials: H
authors.lastname: Chheda
authors.affiliation: Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki FI-00014, Finland.|Department of Computer Science, Aalto University, Espoo 02150, Finland.|Helsinki Institute for Information Technology (HIIT), Esbo 02150, Finland.
authors.forename: Lu
authors.initials: L
authors.lastname: Cheng
authors.affiliation: Helsinki Institute for Information Technology (HIIT), Esbo 02150, Finland.|Department of Mathematics and Statistics, University of Helsinki, Helsinki FI-00014, Finland.
authors.forename: Jukka
authors.initials: J
authors.lastname: Corander
authors.affiliation: Stanford Center for Biomedical Informatics, Stanford University, Stanford, California 94305, USA.
authors.forename: Michel
authors.identifier: http://orcid.org/0000-0003-4727-9435
authors.initials: M
authors.lastname: Dumontier
authors.affiliation: Department of Computer Science, University of Toronto, Toronto, Ontario, Canada M5G OA5.|Genetics and Genome Biology, SickKids Research Institute, Toronto, Ontario, Canada M5G 0A4.
authors.forename: Anna
authors.initials: A
authors.lastname: Goldenberg
authors.affiliation: Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki FI-00014, Finland.
authors.forename: Peddinti
authors.identifier: http://orcid.org/0000-0002-8767-968X
authors.initials: P
authors.lastname: Gopalacharyulu
authors.affiliation: Genetics and Genome Biology, SickKids Research Institute, Toronto, Ontario, Canada M5G 0A4.
authors.forename: Mohsen
authors.initials: M
authors.lastname: Hajiloo
authors.affiliation: Department of Computer Science, University of Toronto, Toronto, Ontario, Canada M5G OA5.|Genetics and Genome Biology, SickKids Research Institute, Toronto, Ontario, Canada M5G 0A4.
authors.forename: Daniel
authors.initials: D
authors.lastname: Hidru
authors.affiliation: Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki FI-00014, Finland.
authors.forename: Alok
authors.initials: A
authors.lastname: Jaiswal
authors.affiliation: Department of Computer Science, Aalto University, Espoo 02150, Finland.|Helsinki Institute for Information Technology (HIIT), Esbo 02150, Finland.|Department of Computer Science, University of Helsinki, Helsinki FI-00014, Finland.
authors.forename: Samuel
authors.initials: S
authors.lastname: Kaski
authors.affiliation: Genetics and Genome Biology, SickKids Research Institute, Toronto, Ontario, Canada M5G 0A4.
authors.forename: Beyrem
authors.initials: B
authors.lastname: Khalfaoui
authors.affiliation: Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki FI-00014, Finland.|Department of Computer Science, Aalto University, Espoo 02150, Finland.|Helsinki Institute for Information Technology (HIIT), Esbo 02150, Finland.
authors.forename: Suleiman Ali
authors.initials: SA
authors.lastname: Khan
authors.affiliation: Department of Integrative Structural and Computational Biology, The Scripps Translational Science Institute, The Scripps Research Institute, La Jolla, California 92037, USA.
authors.forename: Eric R
authors.initials: ER
authors.lastname: Kramer
authors.affiliation: Department of Computer Science, Aalto University, Espoo 02150, Finland.|Helsinki Institute for Information Technology (HIIT), Esbo 02150, Finland.
authors.forename: Pekka
authors.initials: P
authors.lastname: Marttinen
authors.affiliation: Department of Computer Science, University of Toronto, Toronto, Ontario, Canada M5G OA5.|Genetics and Genome Biology, SickKids Research Institute, Toronto, Ontario, Canada M5G 0A4.
authors.forename: Aziz M
authors.initials: AM
authors.lastname: Mezlini
authors.affiliation: Department of Integrative Structural and Computational Biology, The Scripps Translational Science Institute, The Scripps Research Institute, La Jolla, California 92037, USA.
authors.forename: Bhuvan
authors.initials: B
authors.lastname: Molparia
authors.affiliation: Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki FI-00014, Finland.
authors.forename: Matti
authors.initials: M
authors.lastname: Pirinen
authors.affiliation: Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki FI-00014, Finland.
authors.forename: Janna
authors.initials: J
authors.lastname: Saarela
authors.affiliation: Center for Medical Statistics, Informatics, and Intelligent Systems, Medical University of Vienna, Vienna 1090, Austria.
authors.forename: Matthias
authors.initials: M
authors.lastname: Samwald
authors.affiliation: MINES ParisTech, PSL-Research University, CBIO-Centre for Computational Biology, Fontainebleau 77300, France.|Institut Curie, Paris 75248, France.|Bioinformatics, Biostatistics, Epidemiology and Computational Systems Biology of Cancer, INSERM U900, Paris 75248, France.
authors.forename: Véronique
authors.initials: V
authors.lastname: Stoven
authors.affiliation: Quantitative Biomedical Research Center, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA.
authors.forename: Hao
authors.initials: H
authors.lastname: Tang
authors.affiliation: Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki FI-00014, Finland.
authors.forename: Jing
authors.initials: J
authors.lastname: Tang
authors.affiliation: Department of Integrative Structural and Computational Biology, The Scripps Translational Science Institute, The Scripps Research Institute, La Jolla, California 92037, USA.
authors.forename: Ali
authors.initials: A
authors.lastname: Torkamani
authors.affiliation: MINES ParisTech, PSL-Research University, CBIO-Centre for Computational Biology, Fontainebleau 77300, France.|Institut Curie, Paris 75248, France.|Bioinformatics, Biostatistics, Epidemiology and Computational Systems Biology of Cancer, INSERM U900, Paris 75248, France.
authors.forename: Jean-Phillipe
authors.initials: JP
authors.lastname: Vert
authors.affiliation: Quantitative Biomedical Research Center, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA.
authors.forename: Bo
authors.initials: B
authors.lastname: Wang
authors.affiliation: Quantitative Biomedical Research Center, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA.
authors.forename: Tao
authors.identifier: http://orcid.org/0000-0002-4355-149X
authors.initials: T
authors.lastname: Wang
authors.affiliation: Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki FI-00014, Finland.
authors.forename: Krister
authors.initials: K
authors.lastname: Wennerberg
authors.affiliation: Department of Integrative Structural and Computational Biology, The Scripps Translational Science Institute, The Scripps Research Institute, La Jolla, California 92037, USA.
authors.forename: Nathan E
authors.initials: NE
authors.lastname: Wineinger
authors.affiliation: Quantitative Biomedical Research Center, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA.
authors.forename: Guanghua
authors.initials: G
authors.lastname: Xiao
authors.affiliation: Quantitative Biomedical Research Center, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA.|Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA.
authors.forename: Yang
authors.initials: Y
authors.lastname: Xie
authors.affiliation: Department of Paediatrics, Department of Immunology, Institute of Medical Sciences, University of Toronto, Toronto, Ontario, Canada M5S 1A8.|Cell Biology, SickKids Research Institute, Toronto, Ontario, Canada M5G 0A4.
authors.forename: Rae
authors.initials: R
authors.lastname: Yeung
authors.affiliation: Quantitative Biomedical Research Center, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA.|Center for the Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA.
authors.forename: Xiaowei
authors.initials: X
authors.lastname: Zhan
authors.affiliation: Department of Computer Science, University of Toronto, Toronto, Ontario, Canada M5G OA5.|Genetics and Genome Biology, SickKids Research Institute, Toronto, Ontario, Canada M5G 0A4.
authors.forename: Cheng
authors.initials: C
authors.lastname: Zhao
authors.affiliation: Sage Bionetworks, Seattle, Washington 98115, USA.|Department of Medicine, New York University School of Medicine, New York, New York 10003, USA.
authors.forename: Jeff
authors.initials: J
authors.lastname: Greenberg
authors.affiliation: Department of Medicine, Division of Rheumatology, Albany Medical College, Albany, New York 12206, USA.
authors.forename: Joel
authors.initials: J
authors.lastname: Kremer
authors.affiliation: Department of Medicine, University of Nebraska Medical Center, Omaha, Nebraska 68198, USA.|National Data Bank for Rheumatic Diseases, Wichita, Kansas 67214, USA.
authors.forename: Kaleb
authors.initials: K
authors.lastname: Michaud
authors.affiliation: Arthritis Research UK Centre for Genetics and Genomics, Centre for Musculoskeletal Research, Manchester Academic Health Sciences Centre, The University of Manchester, Manchester M13 9PT, UK.|NIHR Manchester Musculoskeletal Biomedical Research Unit, Central Manchester Foundation Trust, Manchester M13 9WU, UK.
authors.forename: Anne
authors.identifier: http://orcid.org/0000-0003-3316-2527
authors.initials: A
authors.lastname: Barton
authors.affiliation: Department of Human Genetics, Radboud University Nijmegen Medical Centre, Nijmegen 6525 GA, The Netherlands.
authors.forename: Marieke
authors.initials: M
authors.lastname: Coenen
authors.affiliation: Department of Rheumatology, Université Paris-Sud, Orsay 91400, France.|APHP-Hôpital Bicêtre, Center of Immunology of Viral Infections and Autoimmune Diseases (IMVA) INSERM U1184, Paris 94276, France.
authors.forename: Xavier
authors.initials: X
authors.lastname: Mariette
authors.affiliation: Department of Rheumatology, Université Paris-Sud, Orsay 91400, France.|APHP-Hôpital Bicêtre, Center of Immunology of Viral Infections and Autoimmune Diseases (IMVA) INSERM U1184, Paris 94276, France.
authors.forename: Corinne
authors.initials: C
authors.lastname: Miceli
authors.affiliation: Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA.
authors.forename: Nancy
authors.initials: N
authors.lastname: Shadick
authors.affiliation: Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA.
authors.forename: Michael
authors.initials: M
authors.lastname: Weinblatt
authors.affiliation: Department of Clinical Immunology and Rheumatology, Academic Medical Center/University of Amsterdam, Amsterdam 1105 AZ, The Netherlands.
authors.forename: Niek
authors.initials: N
authors.lastname: de Vries
authors.affiliation: Department of Clinical Immunology and Rheumatology, Academic Medical Center/University of Amsterdam, Amsterdam 1105 AZ, The Netherlands.|Department of Medicine, Cambridge University, Cambridge CB2 1TN, UK.|Department of Rheumatology, Ghent University, Ghent 9000, Belgium.|GlaxoSmithKline, Stevenage SG1 2NY, UK.
authors.forename: Paul P
authors.initials: PP
authors.lastname: Tak
authors.affiliation: Department of Clinical Immunology and Rheumatology, Academic Medical Center/University of Amsterdam, Amsterdam 1105 AZ, The Netherlands.|Clinical Unit, GlaxoSmithKline, Cambridge CB2 0QQ, UK.
authors.forename: Danielle
authors.initials: D
authors.lastname: Gerlag
authors.affiliation: Department of Rheumatology, Leiden University Medical Centre, Leiden 2300 RC, The Netherlands.
authors.forename: Tom W J
authors.initials: TWJ
authors.lastname: Huizinga
authors.affiliation: Department of Rheumatology, Leiden University Medical Centre, Leiden 2300 RC, The Netherlands.
authors.forename: Fina
authors.initials: F
authors.lastname: Kurreeman
authors.affiliation: Merck Research Labs, Merck and Co., Inc., Boston, Massachusetts 02115, USA.
authors.forename: Cornelia F
authors.initials: CF
authors.lastname: Allaart
authors.affiliation: Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA.
authors.forename: S
authors.initials: S
authors.lastname: Louis Bridges
authors.affiliation: Rosalind Russell/Ephraim P Engleman Rheumatology Research Center, Division of Rheumatology, Department of Medicine, University of California San Francisco, San Francisco, California 94143, USA.
authors.forename: Lindsey
authors.initials: L
authors.lastname: Criswell
authors.affiliation: Division of Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA.
authors.forename: Larry
authors.initials: L
authors.lastname: Moreland
authors.affiliation: Rheumatology Unit, Department of Medicine, Karolinska Hospital and Karolinska Institutet, Solna 171 76 Stockholm, Sweden.
authors.forename: Lars
authors.initials: L
authors.lastname: Klareskog
authors.affiliation: Rheumatology Unit, Department of Medicine, Karolinska Hospital and Karolinska Institutet, Solna 171 76 Stockholm, Sweden.
authors.forename: Saedis
authors.initials: S
authors.lastname: Saevarsdottir
authors.affiliation: Rheumatology Unit, Department of Medicine, Karolinska Hospital and Karolinska Institutet, Solna 171 76 Stockholm, Sweden.
authors.forename: Leonid
authors.initials: L
authors.lastname: Padyukov
authors.affiliation: Robert S. Boas Center for Genomics and Human Genetics, Feinstein Institute for Medical Research, North Shore LIJ Health System, Manhasset, New York 11030, USA.
authors.forename: Peter K
authors.initials: PK
authors.lastname: Gregersen
authors.affiliation: Sage Bionetworks, Seattle, Washington 98115, USA.
authors.forename: Stephen
authors.initials: S
authors.lastname: Friend
authors.affiliation: Merck Research Labs, Merck and Co., Inc., Boston, Massachusetts 02115, USA.
authors.forename: Robert
authors.initials: R
authors.lastname: Plenge
authors.affiliation: Icahn Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.|Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.|Department of Informatics, Faculty of Sciences, University of Lisbon, Lisbon 1749-016, Portugal.
authors.forename: Gustavo
authors.initials: G
authors.lastname: Stolovitzky
authors.affiliation: Structural Bioinformatics Group (GRIB/IMIM), Departament de Ciències Experimentals i de la Salut, Universitat Pompeu Fabra, Barcelona 08003, Spain.
authors.forename: Baldo
authors.initials: B
authors.lastname: Oliva
authors.affiliation: Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan 48109, USA.
authors.forename: Yuanfang
authors.initials: Y
authors.lastname: Guan
authors.affiliation: Sage Bionetworks, Seattle, Washington 98115, USA.
authors.forename: Lara M
authors.initials: LM
authors.lastname: Mangravite
mesh_terms: D000328:Adult; D000368:Aged; D000911:Antibodies, Monoclonal / Q000627:therapeutic use; D061067:Antibodies, Monoclonal, Humanized / Q000627:therapeutic use*; D018501:Antirheumatic Agents / Q000627:therapeutic use; D001172:Arthritis, Rheumatoid / Q000188:drug therapy* / Q000235:genetics / Q000473:pathology; D000068582:Certolizumab Pegol / Q000627:therapeutic use; D015331:Cohort Studies; D063045:Crowdsourcing; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D011379:Prognosis; D016896:Treatment Outcome; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors* / Q000276:immunology
chemical_list: D000911:Antibodies, Monoclonal; D061067:Antibodies, Monoclonal, Humanized; D018501:Antirheumatic Agents; D014409:Tumor Necrosis Factor-alpha; C529000:golimumab; D000068582:Certolizumab Pegol