title: Long noncoding RNA C17orf91 is a potential prognostic marker and functions as an oncogene in ovarian cancer.
abstract: BACKGROUND
  This study was aimed to explore the role of long noncoding RNA C17orf91 and its potential mechanisms in ovarian cancer development.
  
  
  RESULTS
  To assess its role in ovarian cancer, microarray datasets (GSE14407, GSE30587, and GSE17260) in Gene Expression Omnibus (GEO) were utilized to assess the expression and clinical significance of C17orf91 in ovarian cancer. Next, loss-of-function studies were performed to establish the role of C17orf91 and the underlying mechanisms in ovarian cancer development. It was found that elevated expression of C17orf91 was observed in omental metastases when compared with matched primary ovarian tumors(GSE30587, P = 0.016). Moreover, Log Rank analysis revealed that increased expression of C17orf91 was associated with shorter progression free survival(PFS)(HR = 1.90(1.19-3.03), P = 0.008). Overall survival(OS) also showed a similar trend, but did not reach statistical significance(HR = 1.75(0.97-3.13), P = 0.061). Loss-of-function studies further demonstrated that C17orf91 repression impaired migration, invasion and viability of ovarian cancer cells, and downregulated the pro-metastatic gene, MYC, at both mRNA and protein level.
  
  
  CONCLUSIONS
  Collectively, our findings revealed that C17orf91 was a potential prognostic marker and functioned as an oncogene in ovarian cancer. It remains to be seen whether modulation of C17orf91 expression will cause phenotypic changes in vivo.
authors.affiliation: Obstetrics and Gynecology Hospital, Fudan University, Shanghai, 200011, China.|Department of Obstetrics and Gynecology of Shanghai Medical College, Fudan University, Shanghai, 200032, China.|Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases, Shanghai, 200011, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Li
authors.affiliation: Obstetrics and Gynecology Hospital, Fudan University, Shanghai, 200011, China.|Department of Obstetrics and Gynecology of Shanghai Medical College, Fudan University, Shanghai, 200032, China.|Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases, Shanghai, 200011, China.
authors.forename: Hailin
authors.initials: H
authors.lastname: Yu
authors.affiliation: Obstetrics and Gynecology Hospital, Fudan University, Shanghai, 200011, China.|Department of Obstetrics and Gynecology of Shanghai Medical College, Fudan University, Shanghai, 200032, China.|Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases, Shanghai, 200011, China.
authors.forename: Meili
authors.initials: M
authors.lastname: Xi
authors.affiliation: Obstetrics and Gynecology Hospital, Fudan University, Shanghai, 200011, China. xinludoc@163.com.|Department of Obstetrics and Gynecology of Shanghai Medical College, Fudan University, Shanghai, 200032, China. xinludoc@163.com.|Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases, Shanghai, 200011, China. xinludoc@163.com.|Current address: Department of Gynecology, Obstetrics and Gynecology Hospital of Fudan University, No.419, Fangxie Road, Shanghai, 200011, China. xinludoc@163.com.
authors.forename: Xin
authors.initials: X
authors.lastname: Lu
mesh_terms: D014408:Biomarkers, Tumor / Q000235:genetics*; D045744:Cell Line, Tumor; D002465:Cell Movement; D002470:Cell Survival; D030541:Databases, Genetic; D018572:Disease-Free Survival; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D035683:MicroRNAs / Q000235:genetics*; D009362:Neoplasm Metastasis; D018297:Neoplasms, Cystic, Mucinous, and Serous / Q000235:genetics* / Q000473:pathology; D010051:Ovarian Neoplasms / Q000235:genetics* / Q000473:pathology; D011379:Prognosis; D062085:RNA, Long Noncoding / Q000235:genetics*; D015854:Up-Regulation
chemical_list: D014408:Biomarkers, Tumor; C548375:MIRN22 microRNA, human; D035683:MicroRNAs; D062085:RNA, Long Noncoding
keywords: C17orf91; Long noncoding RNA; MYC; Ovarian cancer