title: Model system for multifunctional delivery nanoplatforms based on DNA-Polymer complexes containing silver nanoparticles and fluorescent dye.
abstract: Creation of multifunctional nanoplatforms is one of the new approaches to complex treatment and diagnosis with the monitoring of the curative process. Inclusion of various components into the drug delivery system may reduce toxicity and enhance or modify the therapeutic effects of medicines. In particular, some properties of metal nanoparticles and nanoclusters provide the ability to create new systems for treatment and diagnosis of diseases, biocatalysis and imaging of objects. For example, the ability of metal nanoparticles to enhance the quantum yield of luminescence can be used in bioimaging and therapy. The aim of the research was to construct and examine a multicomponent system based on DNA-polycation compact structure with the inclusion of silver nanoparticles and luminescent dye as a model system for delivery of genes and drugs with the possibility of modification and enhancement of their action.
authors.affiliation: Department of Physics, St. Petersburg State University, 7-9 Universitetskaya Nab.199034, Saint Petersburg, United States. Electronic address: nkasyanenko@mail.ru.
authors.forename: Nina
authors.initials: N
authors.lastname: Kasyanenko
authors.affiliation: Department of Physics, St. Petersburg State University, 7-9 Universitetskaya Nab.199034, Saint Petersburg, United States.
authors.forename: Vladimir
authors.initials: V
authors.lastname: Bakulev
authors.affiliation: Department of Physics, St. Petersburg State University, 7-9 Universitetskaya Nab.199034, Saint Petersburg, United States.
authors.forename: Igor
authors.initials: I
authors.lastname: Perevyazko
authors.affiliation: Institute of Macromolecular Compounds, Russian Academy of Sciences, 199004, Bolshoy pr. 31, Saint Petersburg, United States.
authors.forename: Tatiana
authors.initials: T
authors.lastname: Nekrasova
authors.affiliation: Institute of Macromolecular Compounds, Russian Academy of Sciences, 199004, Bolshoy pr. 31, Saint Petersburg, United States.
authors.forename: Olga
authors.initials: O
authors.lastname: Nazarova
authors.affiliation: Research Institute of Influenza, Molecular Virology Department, 15/17, Prof. Popova str., St. Petersburg, 197376 Russia.
authors.forename: Alexandr
authors.initials: A
authors.lastname: Slita
authors.affiliation: Institute of Macromolecular Compounds, Russian Academy of Sciences, 199004, Bolshoy pr. 31, Saint Petersburg, United States.
authors.forename: Yulia
authors.initials: Y
authors.lastname: Zolotova
authors.affiliation: Institute of Macromolecular Compounds, Russian Academy of Sciences, 199004, Bolshoy pr. 31, Saint Petersburg, United States; St. Petersburg Polytechnic University, 195251, Polytechnicheskaya st. 29, St. Petersburg, Russia.
authors.forename: Euginii
authors.initials: E
authors.lastname: Panarin
mesh_terms: D045744:Cell Line, Tumor; D004247:DNA / Q000737:chemistry* / Q000493:pharmacokinetics; D016503:Drug Delivery Systems / Q000379:methods*; D005456:Fluorescent Dyes / Q000737:chemistry* / Q000493:pharmacokinetics; D005822:Genetic Vectors / Q000235:genetics / Q000493:pharmacokinetics; D006801:Humans; D053768:Metal Nanoparticles / Q000737:chemistry*; D008689:Methacrylates / Q000737:chemistry*; D036103:Nanotechnology / Q000379:methods*; D009757:Nylons / Q000737:chemistry*; D012834:Silver / Q000737:chemistry* / Q000493:pharmacokinetics
chemical_list: D005456:Fluorescent Dyes; D008689:Methacrylates; D009757:Nylons; C407037:poly(2-(dimethylamino)ethyl methacrylate); D012834:Silver; D004247:DNA
keywords: DNA-PDMAEM complexes; Gene vectors with silver nanoparticles and fluorescent dye; Silver nanoparticles