title: Cinnamomi Cortex (Cinnamomum verum) Suppresses Testosterone-induced Benign Prostatic Hyperplasia by Regulating 5α-reductase.
abstract: Cinnamomi cortex (dried bark of Cinnamomum verum) is an important drug in Traditional Korean Medicine used to improve blood circulation and Yang Qi. Benign prostatic hyperplasia (BPH) is a common chronic disease in aging men. This study was conducted to determine the effect of Cinnamomi cortex water extract (CC) on BPH. BPH was induced by a pre-4-week daily injection of testosterone propionate (TP). Six weeks of further injection with (a) vehicle, (b) TP, (c) TP + CC, (d) TP + finasteride (Fi) was carried on. As a result, the prostate weight and prostatic index of the CC treatment group were reduced. Histological changes including epithelial thickness and lumen area were recovered as normal by CC treatment. The protein expressions of prostate specific antigen, estrogen receptor α (ERα), androgen receptor (AR), 5α-reductase (5AR), and steroid receptor coactivator 1 were suppressed by treatment of CC. Immunohistochemical assays supported the western blot results, as the expressions of AR and ERα were down-regulated by CC treatment as well. Further in vitro experiments showed CC was able to inhibit proliferation of RWPE-1 cells by suppressing 5AR and AR. These results all together suggest CC as a potential treatment for BPH.
authors.affiliation: College of Korean Medicine, Basic Research Laboratory for Comorbidity Regulation, Kyung Hee University, 26 Kyungheedae-ro, Dongdaemun-Gu, Seoul, 130-701, Republic of Korea.
authors.forename: Hyun-Myung
authors.initials: HM
authors.lastname: Choi
authors.affiliation: Department of Science in Korean Medicine, Graduate School, Kyung Hee University, 26 Kyungheedae-ro, Dongdaemun-Gu, Seoul, 130-701, Republic of Korea.
authors.forename: Yunu
authors.initials: Y
authors.lastname: Jung
authors.affiliation: Department of Science in Korean Medicine, Graduate School, Kyung Hee University, 26 Kyungheedae-ro, Dongdaemun-Gu, Seoul, 130-701, Republic of Korea.
authors.forename: Jinbong
authors.initials: J
authors.lastname: Park
authors.affiliation: College of Korean Medicine, Basic Research Laboratory for Comorbidity Regulation, Kyung Hee University, 26 Kyungheedae-ro, Dongdaemun-Gu, Seoul, 130-701, Republic of Korea.
authors.forename: Hye-Lin
authors.initials: HL
authors.lastname: Kim
authors.affiliation: Department of Science in Korean Medicine, Graduate School, Kyung Hee University, 26 Kyungheedae-ro, Dongdaemun-Gu, Seoul, 130-701, Republic of Korea.
authors.forename: Dong-Hyun
authors.initials: DH
authors.lastname: Youn
authors.affiliation: Department of Science in Korean Medicine, Graduate School, Kyung Hee University, 26 Kyungheedae-ro, Dongdaemun-Gu, Seoul, 130-701, Republic of Korea.
authors.forename: JongWook
authors.initials: J
authors.lastname: Kang
authors.affiliation: College of Korean Medicine, Basic Research Laboratory for Comorbidity Regulation, Kyung Hee University, 26 Kyungheedae-ro, Dongdaemun-Gu, Seoul, 130-701, Republic of Korea.
authors.forename: Mi-Young
authors.initials: MY
authors.lastname: Jeong
authors.affiliation: College of Pharmacy, Dongduk Women's University, 60 Hwarang-ro 13-gil, Seongbuk-gu, Seoul, 136-714, Republic of Korea.
authors.forename: Jong-Hyun
authors.initials: JH
authors.lastname: Lee
authors.affiliation: College of Korean Medicine, Basic Research Laboratory for Comorbidity Regulation, Kyung Hee University, 26 Kyungheedae-ro, Dongdaemun-Gu, Seoul, 130-701, Republic of Korea.
authors.forename: Woong Mo
authors.initials: WM
authors.lastname: Yang
authors.affiliation: College of Korean Medicine, Basic Research Laboratory for Comorbidity Regulation, Kyung Hee University, 26 Kyungheedae-ro, Dongdaemun-Gu, Seoul, 130-701, Republic of Korea.
authors.forename: Seok-Geun
authors.initials: SG
authors.lastname: Lee
authors.affiliation: College of Korean Medicine, Basic Research Laboratory for Comorbidity Regulation, Kyung Hee University, 26 Kyungheedae-ro, Dongdaemun-Gu, Seoul, 130-701, Republic of Korea.
authors.forename: Kwang Seok
authors.initials: KS
authors.lastname: Ahn
authors.affiliation: College of Korean Medicine, Basic Research Laboratory for Comorbidity Regulation, Kyung Hee University, 26 Kyungheedae-ro, Dongdaemun-Gu, Seoul, 130-701, Republic of Korea.|Department of Science in Korean Medicine, Graduate School, Kyung Hee University, 26 Kyungheedae-ro, Dongdaemun-Gu, Seoul, 130-701, Republic of Korea.
authors.forename: Jae-Young
authors.initials: JY
authors.lastname: Um
mesh_terms: D000818:Animals; D002460:Cell Line; D049109:Cell Proliferation / Q000187:drug effects; D042944:Cholestenone 5 alpha-Reductase / Q000378:metabolism*; D002935:Cinnamomum zeylanicum / Q000737:chemistry; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D004847:Epithelial Cells / Q000187:drug effects / Q000378:metabolism; D006801:Humans; D008297:Male; D008517:Phytotherapy / Q000379:methods; D011467:Prostate / Q000187:drug effects* / Q000378:metabolism; D011470:Prostatic Hyperplasia / Q000139:chemically induced / Q000378:metabolism / Q000517:prevention & control*; D017207:Rats, Sprague-Dawley; D011944:Receptors, Androgen / Q000378:metabolism; D043343:Testosterone Propionate
chemical_list: D004365:Drugs, Chinese Herbal; D011944:Receptors, Androgen; C532132:cinnamomi cortex; D042944:Cholestenone 5 alpha-Reductase; D043343:Testosterone Propionate