title: Targeting cancer with hyaluronic acid-based nanocarriers: recent advances and translational perspectives.
abstract: Hyaluronic acid is a natural polysaccharide that has been widely explored for the development of anticancer therapies due to its ability to target cancer cells. Moreover, advances made in the last decade have revealed the versatility of this biomaterial in the design of multifunctional carriers, intended for the delivery of a variety of bioactive molecules, including polynucleotides, immunomodulatory drugs and imaging agents. In this review, we aim to provide an overview of the major recent achievements in this field, highlighting the application of the newly developed nanostructures in combination therapies, immunomodulation and theranostics. Finally, we will discuss the main challenges and technological advances that will allow these carriers to be considered as candidates for clinical development.
authors.affiliation: NanoBioFar Group, Center for Research in Molecular Medicine & Chronic Diseases, Health Research Institute of Santiago de Compostela (IDIS), Department of Pharmacy & Pharmaceutical Technology, School of Pharmacy, Campus Vida, University of Santiago de Compostela (USC), Avenida Barcelona s/n, 15782 Santiago de Compostela, Spain.
authors.forename: Ana
authors.initials: A
authors.lastname: Cadete
authors.affiliation: NanoBioFar Group, Center for Research in Molecular Medicine & Chronic Diseases, Health Research Institute of Santiago de Compostela (IDIS), Department of Pharmacy & Pharmaceutical Technology, School of Pharmacy, Campus Vida, University of Santiago de Compostela (USC), Avenida Barcelona s/n, 15782 Santiago de Compostela, Spain.
authors.forename: María José
authors.initials: MJ
authors.lastname: Alonso
mesh_terms: D000276:Adjuvants, Immunologic / Q000008:administration & dosage / Q000627:therapeutic use; D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000627:therapeutic use; D004337:Drug Carriers / Q000737:chemistry / Q000378:metabolism*; D016503:Drug Delivery Systems / Q000379:methods; D006801:Humans; D006820:Hyaluronic Acid / Q000737:chemistry / Q000378:metabolism*; D007167:Immunotherapy / Q000379:methods; D050997:Nanomedicine / Q000379:methods*; D053758:Nanoparticles / Q000737:chemistry / Q000378:metabolism; D009369:Neoplasms / Q000188:drug therapy* / Q000628:therapy; D057170:Translational Research, Biomedical / Q000379:methods
chemical_list: D000276:Adjuvants, Immunologic; D000970:Antineoplastic Agents; D004337:Drug Carriers; D006820:Hyaluronic Acid
keywords: cancer nanotechnology; hyaluronic acid; immunotherapy; translational research