title: The Alterations of Cortical Volume, Thickness, Surface, and Density in the Intermediate Sporadic Parkinson's Disease from the Han Population of Mainland China.
abstract: Many symptoms of sporadic Parkinson's disease (sPD) can't be completely explained by the lesion of simple typical extrapyramidal circuit between striatum and substantia nigra. Therefore, we investigated the alteration of cortical volume, thickness, surface, and density in the intermediate sPD from the Han population of Mainland China in order to find the new pathological brain regions associated with the complex clinical manifestations of sPD. The cortical volume, thickness, surface and density were examined using the voxel-based cortical morphometry and corticometry on magnetic resonance image (MRI) in 67 intermediate sPD and 35 controls, the multiple adjusted comparisons analysis of all MRI data were employed to assess the relationships between the cortical morphometric alteration in the specific brain regions and sPD. Results showed that a significantly shrunk volume, thinned thickness and enlarged or reduced surface of cortex in some specific brain regions were closely associated with sPD, but all cortical densities were not different. The majority of morphometric alteration of hemisphere cortex was symmetric, but that in the left hemisphere was more significant. The cortical morphometric alterations in the frontal, temporal, parietal, occipital and limbic lobe, cerebellum, caudate, and thalamus were closely related to the clinical neural dysfunction (Clinical manifestations) of sPD. Our data indicated that the deficits of extensive brain regions involved in the development of sPD, resulted in a series of correspondent complex clinical manifestations in the disease.
authors.affiliation: Department of Neurology, First Affiliated Hospital of Nanchang University Nanchang, China.
authors.forename: Xia
authors.initials: X
authors.lastname: Deng
authors.affiliation: Department of Neurology, First Affiliated Hospital of Nanchang University Nanchang, China.
authors.forename: Meihong
authors.initials: M
authors.lastname: Zhou
authors.affiliation: Department of Neurology, First Affiliated Hospital of Nanchang University Nanchang, China.
authors.forename: Chunyan
authors.initials: C
authors.lastname: Tang
authors.affiliation: Department of Neurology, First Affiliated Hospital of Nanchang UniversityNanchang, China; Department of Biochemistry and Molecular Biology, College of Basic Medical Science, Nanchang UniversityNanchang, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Department of Neurology, First Affiliated Hospital of Nanchang University Nanchang, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Zhu
authors.affiliation: Department of Neurology, First Affiliated Hospital of Nanchang University Nanchang, China.
authors.forename: Zunchun
authors.initials: Z
authors.lastname: Xie
authors.affiliation: Department of Radiology, First Affiliated Hospital of Nanchang University Nanchang, China.
authors.forename: Honghan
authors.initials: H
authors.lastname: Gong
authors.affiliation: Department of Biochemistry and Molecular Biology, College of Basic Medical Science, Nanchang University Nanchang, China.
authors.forename: Xiangzuo
authors.initials: X
authors.lastname: Xiao
authors.affiliation: Department of Neurology, First Affiliated Hospital of Nanchang University Nanchang, China.
authors.forename: Renshi
authors.initials: R
authors.lastname: Xu
keywords: Han population; Mainland China; cortical morphometry; magnetic resonance image; sporadic Parkinson's disease