title: C-reactive Protein Level, Apolipoprotein B-to-apolipoprotein A-1 Ratio, and Risks of Ischemic Stroke and Coronary Heart Disease among Inner Mongolians in China.
abstract: OBJECTIVE
  We aimed to investigate the cumulative effect of high CRP level and apolipoprotein B-to-apolipoprotein A-1 (ApoB/ApoA-1) ratio on the incidence of ischemic stroke (IS) or coronary heart disease (CHD) in a Mongolian population in China.
  
  
  METHODS
  From June 2003 to July 2012, 2589 Mongolian participants were followed up for IS and CHD events based on baseline investigation. All the participants were divided into four subgroups according to C-reactive protein (CRP) level and ApoB/ApoA-1 ratio. Cox proportional hazard models were used to estimate the hazard ratios (HRs) and 95% confidence intervals (CIs) for the IS and CHD events in all the subgroups.
  
  
  RESULTS
  The HRs (95% CI) for IS and CHD were 1.33 (0.84-2.12), 1.14 (0.69-1.88), and 1.91 (1.17-3.11) in the 'low CRP level with high ApoB/ApoA-1', 'high CRP level with low ApoB/ApoA-1', and 'high CRP level with high ApoB/ApoA-1' subgroups, respectively, in comparison with the 'low CRP level with low ApoB/ApoA-1' subgroup. The risks of IS and CHD events was highest in the 'high CRP level with high ApoB/ApoA-1' subgroup, with statistical significance.
  
  
  CONCLUSIONS
  High CRP level with high ApoB/ApoA-1 ratio was associated with the highest risks of IS and CHD in the Mongolian population. This study suggests that the combination of high CRP and ApoB/ApoA-1 ratio may improve the assessment of future risk of developing IS and CHD in the general population.
authors.affiliation: Department of Epidemiology, School of Public Health and Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Medical College of Soochow University, Suzhou 215123, Jiangsu, China.
authors.forename: Yun Fan
authors.initials: YF
authors.lastname: Tian
authors.affiliation: Department of Epidemiology, School of Public Health and Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Medical College of Soochow University, Suzhou 215123, Jiangsu, China.
authors.forename: Yi Peng
authors.initials: YP
authors.lastname: Zhou
authors.affiliation: Department of Epidemiology, School of Public Health and Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Medical College of Soochow University, Suzhou 215123, Jiangsu, China.
authors.forename: Chong Ke
authors.initials: CK
authors.lastname: Zhong
authors.affiliation: Department of Epidemiology, Tongliao Center for Disease Prevention and Control, Tongliao 028005, Inner Mongolia, China.
authors.forename: Batu
authors.initials: B
authors.lastname: Buren
authors.affiliation: Department of Epidemiology, School of Public Health and Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Medical College of Soochow University, Suzhou 215123, Jiangsu, China; Department of Neurology, Affiliated Hospital of Nantong University, Nantong 226001, Jiangsu, China.
authors.forename: Tian
authors.initials: T
authors.lastname: Xu
authors.affiliation: Department of Epidemiology, School of Public Health and Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Medical College of Soochow University, Suzhou 215123, Jiangsu, China.
authors.forename: Hong Mei
authors.initials: HM
authors.lastname: Li
authors.affiliation: Department of Epidemiology, School of Public Health and Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Medical College of Soochow University, Suzhou 215123, Jiangsu, China.
authors.forename: Ming Zhi
authors.initials: MZ
authors.lastname: Zhang
authors.affiliation: Department of Epidemiology, School of Public Health and Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Medical College of Soochow University, Suzhou 215123, Jiangsu, China.
authors.forename: Ai Li
authors.initials: AL
authors.lastname: Wang
authors.affiliation: Department of Epidemiology, School of Public Health and Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Medical College of Soochow University, Suzhou 215123, Jiangsu, China.
authors.forename: Yong Hong
authors.initials: YH
authors.lastname: Zhang
mesh_terms: D000328:Adult; D001054:Apolipoproteins A / Q000145:classification / Q000235:genetics / Q000378:metabolism*; D001055:Apolipoproteins B / Q000235:genetics / Q000378:metabolism*; D002097:C-Reactive Protein / Q000235:genetics / Q000378:metabolism*; D015331:Cohort Studies; D003327:Coronary Disease / Q000453:epidemiology / Q000209:etiology*; D005786:Gene Expression Regulation; D006801:Humans; D008986:Mongolia / Q000453:epidemiology; D011446:Prospective Studies; D012307:Risk Factors; D020521:Stroke / Q000453:epidemiology / Q000209:etiology*; D055815:Young Adult
chemical_list: D001054:Apolipoproteins A; D001055:Apolipoproteins B; D002097:C-Reactive Protein
keywords: Apolipoprotein B-to-apolipoprotein A-1 ratio; C-reactive protein; Coronary heart disease; Ischemic stroke