title: Superior outcomes of kidney transplantation compared with dialysis: An optimal matched analysis of a national population-based cohort study between 2005 and 2008 in Korea.
abstract: Data regarding kidney transplantation (KT) and dialysis outcomes are rare in Asian populations. In the present study, we evaluated the clinical outcomes associated with KT using claims data from the Korean national public health insurance program. Among the 35,418 adult patients with incident dialysis treated between 2005 and 2008 in Korea, 1539 underwent KT. An optimal balanced risk set matching was attempted to compare the transplant group with the control group in terms of the overall survival and major adverse cardiac event-free survival. Before matching, the dialysis group was older and had more comorbidities. After matching, there were no differences in age, sex, dialysis modalities, or comorbidities. Patient survival was significantly better in the transplant group than in the matched control group (P < 0.001). In addition, the transplant group showed better major adverse cardiac event-free survival than the dialysis group (P < 0.001; hazard ratio, 0.49; 95% confidence interval, 0.32-0.75). Korean patients with incident dialysis who underwent long-term dialysis had significantly more cardiovascular events and higher all-cause mortality rates than those who underwent KT. Thus, KT should be more actively recommended in Korean populations.
authors.affiliation: Department of Internal Medicine, Division of Nephrology, Dongguk University Medical Center School of Public Health, Seoul National University, Seoul Department of Dental Hygiene, College of Health Science, Eulji University, Daejeon College of Engineering, Seoul National University Department of Internal Medicine, Seoul National University Boramae Medical Center Department of Internal Medicine, Seoul National University College of Medicine Department of Public Health, Graduate School, Korea University, Seoul Department of Internal Medicine, Wonkwang University College of Medicine, Sanbon Hospital, Gyeonggi-do Department of Internal Medicine, School of Medicine, Ewha Womans University, Seoul, Republic of Korea.
authors.forename: Kyung Don
authors.initials: KD
authors.lastname: Yoo
authors.forename: Clara Tammy
authors.initials: CT
authors.lastname: Kim
authors.forename: Myoung-Hee
authors.initials: MH
authors.lastname: Kim
authors.forename: Junhyug
authors.initials: J
authors.lastname: Noh
authors.forename: Gunhee
authors.initials: G
authors.lastname: Kim
authors.forename: Ho
authors.initials: H
authors.lastname: Kim
authors.forename: Jung Nam
authors.initials: JN
authors.lastname: An
authors.forename: Jae Yoon
authors.initials: JY
authors.lastname: Park
authors.forename: Hyunjeong
authors.initials: H
authors.lastname: Cho
authors.forename: Kyoung Hoon
authors.initials: KH
authors.lastname: Kim
authors.forename: Hyunwook
authors.initials: H
authors.lastname: Kim
authors.forename: Dong-Ryeol
authors.initials: DR
authors.lastname: Ryu
authors.forename: Dong Ki
authors.initials: DK
authors.lastname: Kim
authors.forename: Chun Soo
authors.initials: CS
authors.lastname: Lim
authors.forename: Yon Su
authors.initials: YS
authors.lastname: Kim
authors.forename: Jung Pyo
authors.initials: JP
authors.lastname: Lee
mesh_terms: D000328:Adult; D015331:Cohort Studies; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000401:mortality / Q000601:surgery / Q000628:therapy; D016030:Kidney Transplantation / Q000401:mortality / Q000706:statistics & numerical data; D008297:Male; D008875:Middle Aged; D006435:Renal Dialysis / Q000401:mortality / Q000706:statistics & numerical data; D056910:Republic of Korea; D016019:Survival Analysis; D016896:Treatment Outcome