title: [Antidepressant guidelines poorly adhered to in young people].
abstract: To examine if Dutch physicians adhere to the national guidelines on the treatment of depression in children and adolescents.
  
  
  
  Retrospective database research.
  
  
  
  Data on children and adolescents aged between 6 and 17 years were selected from the IADB, a Dutch database of filled prescriptions. We examined whether children and adolescents were prescribed fluoxetine as recommended by the guideline, and whether the starting dose was in accordance with the guideline.
  
  
  
  Of 2942 children and adolescents in whom antidepressant treatment was initiated, the proportion prescribed fluoxetine increased from 10.1% in 1994-2003 to 19.7% in 2010-2014. However, paroxetine (1994-2003) and citalopram (2004-2014) were the most frequently prescribed antidepressants. Starting doses were guideline-concordant in 58% of children, 31% of preadolescents and 16% of adolescents. Sixty percent of all adolescents were prescribed an adult starting dose.
  
  
  
  Guideline adherence was poor. In contrast to the guidelines, physicians preferred citalopram to fluoxetine in children and adolescents with depression. Furthermore, adolescents often received an adult starting dose. These results suggest that dedicated effort is necessary to improve guideline adherence.
authors.affiliation: *Dit onderzoek werd eerder gepubliceerd in European Child and Adolescent Psychiatry (17 maart 2016 (epub)) met als titel 'Poor guideline adherence in the initiation of antidepressant treatment in children and adolescents in the Netherlands: choice of antidepressant and dose'. Afgedrukt met toestemming.
authors.forename: Y A
authors.initials: YA
authors.lastname: de Vries
authors.forename: P
authors.initials: P
authors.lastname: de Jonge
authors.forename: L
authors.initials: L
authors.lastname: Kalverdijk
authors.forename: H J
authors.initials: HJ
authors.lastname: Bos
authors.forename: C C M
authors.initials: CC
authors.lastname: Schuiling-Veninga
authors.forename: E
authors.initials: E
authors.lastname: Hak
mesh_terms: D000293:Adolescent; D018687:Antidepressive Agents, Second-Generation / Q000627:therapeutic use; D002648:Child; D003866:Depressive Disorder / Q000188:drug therapy*; D004305:Dose-Response Relationship, Drug; D005260:Female; D005473:Fluoxetine / Q000627:therapeutic use*; D019983:Guideline Adherence; D006801:Humans; D008297:Male; D017374:Paroxetine / Q000627:therapeutic use*; D010349:Patient Compliance; D012189:Retrospective Studies; D016896:Treatment Outcome
chemical_list: D018687:Antidepressive Agents, Second-Generation; D005473:Fluoxetine; D017374:Paroxetine