title: DNA (De)Methylation: The Passive Route to Naïvety?
abstract: Mouse pluripotent embryonic stem (ES) cells can exist in distinct yet interchangeable epigenetic states dictated by their culture environment. Previous reports have shown that naïve pluripotent cells grown in the presence of 2i are characterised by global DNA hypomethylation and changes in the abundance and distribution of histone modifications. New research provides insights regarding how this might be achieved.
authors.affiliation: MRC Clinical Sciences Centre, Du Cane Road, London W12 0NN, UK; Institute of Clinical Sciences, Faculty of Medicine, Imperial College London, Du Cane Road, London W12 0NN, UK.
authors.forename: Harry G
authors.initials: HG
authors.lastname: Leitch
authors.affiliation: Wellcome Trust/Cancer Research UK Gurdon Institute, University of Cambridge, Tennis Court Road, Cambridge CB2 1QN, UK; Department of Physiology, Development, and Neuroscience, University of Cambridge, Downing Street, Cambridge CB2 3DY, UK.
authors.forename: M Azim
authors.initials: MA
authors.lastname: Surani
authors.affiliation: MRC Clinical Sciences Centre, Du Cane Road, London W12 0NN, UK; Institute of Clinical Sciences, Faculty of Medicine, Imperial College London, Du Cane Road, London W12 0NN, UK. Electronic address: petra.hajkova@csc.mrc.ac.uk.
authors.forename: Petra
authors.initials: P
authors.lastname: Hajkova
mesh_terms: D000818:Animals; D002454:Cell Differentiation / Q000235:genetics; D019175:DNA Methylation / Q000235:genetics*; D053595:Embryonic Stem Cells; D044127:Epigenesis, Genetic; D042421:Histone Code / Q000235:genetics; D051379:Mice; D039904:Pluripotent Stem Cells