title: The immunogenetics of multiple sclerosis. The frequency of HLA-alleles class 1 and 2 is lower in Southern Brazil than in the European population.
abstract: OBJECTIVE
  To study the HLA of class 1and 2 in a multiple sclerosis (MS) population to verify the susceptibility for the disease in the Southern Brazil.
  
  
  METHODS
  We analyzed patients with MS and controls, by direct sequencing of the genes related to HLA DRB1, DQB1, DPB1, A, B and C alleles with high resolution techniques.
  
  
  RESULTS
  We found a lower frequency of all HLA alleles class 1 and 2 in MS and controls comparing to the European population. Several alleles had statistical correlation, but after Bonferroni correction, the only allele with significance was the HLA-DQB1*02:03, which has a positive association with MS.
  
  
  CONCLUSIONS
  Our data have different frequency of HLA-alleles than the previous published papers in the Southeast Brazil and European population, possible due to several ethnic backgrounds.
authors.affiliation: Universidade Federal do Paraná, Hospital de Clínicas, Departamento de Clínica Médica, Serviço de Neurologia, Curitiba PR, Brasil.
authors.forename: Lineu Cesar
authors.initials: LC
authors.lastname: Werneck
authors.affiliation: Universidade Federal do Paraná, Hospital de Clínicas, Departamento de Clínica Médica, Serviço de Neurologia, Curitiba PR, Brasil.
authors.forename: Paulo José
authors.initials: PJ
authors.lastname: Lorenzoni
authors.affiliation: Universidade Federal do Paraná, Hospital de Clínicas, Departamento de Clínica Médica, Serviço de Neurologia, Curitiba PR, Brasil.
authors.forename: Raquel Cristina
authors.initials: RC
authors.lastname: Arndt
authors.affiliation: Universidade Federal do Paraná, Hospital de Clínicas, Departamento de Clínica Médica, Serviço de Neurologia, Curitiba PR, Brasil.
authors.forename: Cláudia Suemi Kamoi
authors.initials: CS
authors.lastname: Kay
authors.affiliation: Universidade Federal do Paraná, Hospital de Clínicas, Departamento de Clínica Médica, Serviço de Neurologia, Curitiba PR, Brasil.
authors.forename: Rosana Herminia
authors.initials: RH
authors.lastname: Scola
mesh_terms: D000293:Adolescent; D000328:Adult; D000483:Alleles; D001938:Brazil; D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D015395:Histocompatibility Antigens Class I / Q000235:genetics*; D000949:Histocompatibility Antigens Class II / Q000235:genetics*; D006801:Humans; D055261:Immunogenetic Phenomena; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000208:ethnology / Q000235:genetics*; D044465:White People; D055815:Young Adult
chemical_list: D015395:Histocompatibility Antigens Class I; D000949:Histocompatibility Antigens Class II