title: Association between the Val34Leu polymorphism in blood coagulation factor XIII-A and intracerebral hemorrhage: a meta-analysis.
abstract: Although the Val34Leu polymorphism in blood coagulation factor XIII-A (FXIII-A) has been implicated in the pathogenesis of intracerebral hemorrhage (ICH), the results of research conducted thus far have been inconclusive. In this meta-analysis, we have assessed the association between the FXIII-A Val34Leu polymorphism and ICH risk. Published reports pertaining to this association were retrieved from the PubMed database, and the data from these studies were pooled and statistically analyzed with Stata 12.0. Summary odds ratios (OR) and 95% confidence intervals (95%CI) were calculated according to a fixed-effect or a random-effect model (as appropriate). The initial search identified 520 articles, only seven of which (retrospective studies) met the inclusion criteria and were included in this meta-analysis. These studies comprised 727 ICH patients and 1968 controls. The results of a combined analysis showed no significant association between the FXIII-A Val34Leu polymorphism and ICH risk in the overall population (Leu/Leu vs Val/Val: OR = 1.41, 95%CI = 0.82-2.43; Val/Leu vs Val/Val: OR = 1.08, 95%CI = 0.89-1.30; dominant model: OR = 1.14, 95%CI = 0.95-1.36; recessive model: OR = 0.72, 95%CI = 0.43-1.22). The results of this meta-analysis suggest that the FXIII-A Val34Leu polymorphism is not associated with ICH risk in a Caucasian population. Further large and well-designed studies must be conducted to confirm this preliminary conclusion.
authors.affiliation: Department of Neurosurgery, Xiasha Branch of Affiliated Sir Run Run Shaw Hospital, Hangzhou, Zhejiang, China.
authors.forename: X
authors.initials: X
authors.lastname: Ye
authors.affiliation: Department of Thoracic Surgery, Hangzhou Red Cross Hospital, Hangzhou, Zhejiang, China yebomed@126.com.
authors.forename: B
authors.initials: B
authors.lastname: Ye
mesh_terms: D019943:Amino Acid Substitution; D002543:Cerebral Hemorrhage / Q000235:genetics*; D026122:Factor XIIIa / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D006801:Humans; D007930:Leucine / Q000235:genetics; D020641:Polymorphism, Single Nucleotide; D014633:Valine / Q000235:genetics
chemical_list: D026122:Factor XIIIa; D007930:Leucine; D014633:Valine