title: Coenzyme A: to make it or uptake it?
abstract: The consensus has been that intracellular coenzyme A (CoA) is obtained exclusively by de novo biosynthesis via a universal, conserved five-step pathway in the cell cytosol. However, old and new evidence suggest that cells (and some microorganisms) have several strategies to obtain CoA, with 4'-phosphopantetheine (P-PantSH; the fourth intermediate in the canonical CoA biosynthetic pathway) serving as a 'nexus' metabolite.
authors.affiliation: Department of Cell Biology, University Medical Center Groningen, University of Groningen, Ant. Deusinglaan 1, 9713 AV Groningen, The Netherlands.
authors.forename: Ody C M
authors.initials: OC
authors.lastname: Sibon
authors.affiliation: Department of Biochemistry, Stellenbosch University, Private Bag X1, Matieland, Stellenbosch 7602, South Africa.
authors.forename: Erick
authors.initials: E
authors.lastname: Strauss
mesh_terms: D000818:Animals; D001692:Biological Transport; D053898:Biosynthetic Pathways; D002463:Cell Membrane Permeability; D003065:Coenzyme A / Q000096:biosynthesis*; D006801:Humans; D010204:Pantetheine / Q000031:analogs & derivatives* / Q000378:metabolism
chemical_list: D010204:Pantetheine; C003129:4'-phosphopantetheine; D003065:Coenzyme A