title: Effect of biomaterials on angiogenesis during vital pulp therapy.
abstract: This review intended to provide an overview of the effects of dental materials, used in dentin-pulp complex and dental pulp regeneration, on angiogenesis processes during regenerative endodontic procedures. An electronic search was performed in PubMed and MEDLINE databases via OVID using the keywords mentioned in the PubMed and MeSH headings for English language published articles from January 2005-April 2014 that evaluated the angiogenic properties of different dental materials used in regenerative endodontic procedures. Of the articles identified in an initial search, only 40 articles met the inclusion criteria set for this review. Vital pulp therapy materials might have positive effects on angiogenesis events, while most of the canal irrigating solutions and antibiotic pastes have anti-angiogenic activity except for EDTA. Future clinical studies will be helpful in defining the mechanisms of action for dental materials that promote or inhibit angiogenesis events at applied areas.
authors.affiliation: Departments of Ophthalmology and Visual Science and Biomedical Engineering, University of Wisconsin, School of Medicine and Public Health.
authors.forename: Mohammad Ali
authors.initials: MA
authors.lastname: Saghiri
authors.forename: Armen
authors.initials: A
authors.lastname: Asatourian
authors.forename: Franklin
authors.initials: F
authors.lastname: Garcia-Godoy
authors.forename: Nader
authors.initials: N
authors.lastname: Sheibani
mesh_terms: D001672:Biocompatible Materials; D003764:Dental Materials; D003782:Dental Pulp; D003790:Dental Pulp Necrosis / Q000628:therapy; D006801:Humans; D018919:Neovascularization, Physiologic; D012038:Regeneration
chemical_list: D001672:Biocompatible Materials; D003764:Dental Materials