title: A longitudinal event-related potential study of selective serotonin reuptake inhibitor therapy in treatment-naïve pediatric obsessive compulsive disorder patients.
abstract: Obsessive-compulsive disorder (OCD) is characterized by obsessive thoughts and/or compulsive behaviors, involving specific cognition and/or information processing disorders. Event-related potentials (ERPs) are commonly used as physiological measures of cognitive function. In conscious patients, ERPs are easily and non-invasively measured. Previous ERP studies have revealed differences between OCD patients and control subjects. Whether ERPs reflect the pharmacological effects of OCD treatment, particularly in treatment-naïve pediatric patients, remains unknown. We used the Child's Yale-Brown Obsessive-Compulsive Scale (CY-BOCS) to evaluate the symptomatic severity of 12 treatment-naïve pediatric OCD patients. Comparisons were made with 12 age-, sex-, and intelligence-matched controls. The P300 and mismatch negativity (MMN) components were measured during an auditory odd-ball task at baseline in both groups and after the 3-year serotonin reuptake inhibitor (SSRI) treatment in OCD patients. Compared with controls, P300 amplitudes were smaller n the OCD group at Fz, Cz, Pz, C3, and C4. After SSRI treatment, P300 amplitudes increased partly at Fz and C4 in association with symptomatic improvements. We found a significant positive correlation between P300 amplitude in C4 and CY-BOCS scores. Our findings confirm the utility of SSRIs in pediatric OCD, and suggest the utility of ERPs for evaluating pharmacological effects in treatment-naïve pediatric OCD patients.
authors.affiliation: Department of Psychiatry, Nara Medical University School of Medicine, Kashihara, Japan. Electronic address: muro@naramed-u.ac.jp.
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Yamamuro
authors.affiliation: Department of Psychiatry, Nara Medical University School of Medicine, Kashihara, Japan.
authors.forename: Toyosaku
authors.initials: T
authors.lastname: Ota
authors.affiliation: Faculty of Nursing, Nara Medical University School of Medicine, Kashihara, Japan.
authors.forename: Junzo
authors.initials: J
authors.lastname: Iida
authors.affiliation: Department of Psychiatry, Nara Medical University School of Medicine, Kashihara, Japan.
authors.forename: Naoko
authors.initials: N
authors.lastname: Kishimoto
authors.affiliation: Department of Psychiatry, Nara Medical University School of Medicine, Kashihara, Japan.
authors.forename: Yoko
authors.initials: Y
authors.lastname: Nakanishi
authors.affiliation: Department of Psychiatry, Tenri Hospital, Tenri, Japan.
authors.forename: Hiroki
authors.initials: H
authors.lastname: Matsuura
authors.affiliation: Department of Psychiatry, Nara Prefectural General Rehabilitation Center, Shiki, Japan.
authors.forename: Mitsuhiro
authors.initials: M
authors.lastname: Uratani
authors.affiliation: Department of Psychiatry, Nara Medical University School of Medicine, Kashihara, Japan.
authors.forename: Kosuke
authors.initials: K
authors.lastname: Okazaki
authors.affiliation: Department of Psychiatry, Nara Medical University School of Medicine, Kashihara, Japan.
authors.forename: Toshifumi
authors.initials: T
authors.lastname: Kishimoto
mesh_terms: D000293:Adolescent; D002648:Child; D003071:Cognition / Q000187:drug effects; D003192:Compulsive Behavior / Q000188:drug therapy / Q000503:physiopathology / Q000523:psychology; D005071:Evoked Potentials / Q000187:drug effects*; D005260:Female; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D009771:Obsessive-Compulsive Disorder / Q000188:drug therapy / Q000503:physiopathology* / Q000523:psychology; D017367:Selective Serotonin Reuptake Inhibitors / Q000627:therapeutic use*
chemical_list: D017367:Selective Serotonin Reuptake Inhibitors
keywords: Event-related potentials; Mismatch negativity; Obsessive-compulsive disorder; P300; Serotonin reuptake inhibitors; Severity