title: Current and Emerging Therapies of Severe Epileptic Encephalopathies.
abstract: In this article, we review the treatment options for the pediatric epileptic encephalopathies and provide an update on the new and emerging therapies targeted at the underlying pathophysiology of many of these syndromes. We illustrate how the identification of the specific genetic and autoimmune causes has made possible the evaluation and development of novel, better targeted therapies, as and at times, avoidance of potentially offending agents.
authors.affiliation: Department of Pediatrics and Neurology, Lebanese American University, Byblos, Lebanon.
authors.forename: Abeer J
authors.initials: AJ
authors.lastname: Hani
authors.affiliation: Division of Pediatric Neurology, Children's Health Center, Duke University Medical Center, Durham, NC. Electronic address: mohamad.mikati@duke.edu.
authors.forename: Mohamad A
authors.initials: MA
authors.lastname: Mikati
mesh_terms: D000927:Anticonvulsants / Q000008:administration & dosage / Q000494:pharmacology*; D004831:Epilepsies, Myoclonic / Q000188:drug therapy* / Q000235:genetics / Q000276:immunology; D006801:Humans; D007223:Infant; D018887:Landau-Kleffner Syndrome / Q000188:drug therapy* / Q000235:genetics / Q000276:immunology; D065768:Lennox Gastaut Syndrome / Q000188:drug therapy* / Q000235:genetics / Q000276:immunology; D013036:Spasms, Infantile / Q000188:drug therapy* / Q000235:genetics / Q000276:immunology
chemical_list: D000927:Anticonvulsants