title: Comparing the Effectiveness of Methods to Measure Oxygen in Tissues for Prognosis and Treatment of Cancer.
abstract: Given the clinical evidence that hypoxic tumors are more resistant to standard therapy and that adjusting therapies can improve the outcomes for the subpopulation with hypoxic tumors, in vivo methods to measure oxygen in tissue have important clinical potential. This paper provides the rationale for and methodological strategies to use comparative effectiveness research to evaluate oximetry for cancer care. Nine oximetry methods that have been used in vivo to measure oxygen in human tumors are evaluated on several clinically relevant criteria to illustrate the value of applying comparative effectiveness to oximetry.
authors.affiliation: EPR Center for the Study of Viable Systems, Department of Radiology, HB 7785, Geisel School of Medicine at Dartmouth, Hanover, NH, USA. ann.b.flood@dartmouth.edu.
authors.forename: Ann Barry
authors.initials: AB
authors.lastname: Flood
authors.affiliation: EPR Center for the Study of Viable Systems, Department of Radiology, HB 7785, Geisel School of Medicine at Dartmouth, Hanover, NH, USA.
authors.forename: Victoria A
authors.initials: VA
authors.lastname: Satinsky
authors.affiliation: EPR Center for the Study of Viable Systems, Department of Radiology, HB 7785, Geisel School of Medicine at Dartmouth, Hanover, NH, USA.
authors.forename: Harold M
authors.initials: HM
authors.lastname: Swartz
mesh_terms: D014408:Biomarkers, Tumor / Q000378:metabolism*; D006801:Humans; D009369:Neoplasms / Q000378:metabolism* / Q000473:pathology / Q000628:therapy; D010092:Oximetry / Q000379:methods*; D010100:Oxygen / Q000378:metabolism*; D011237:Predictive Value of Tests; D015203:Reproducibility of Results; D016896:Treatment Outcome; D000072258:Tumor Hypoxia; D059016:Tumor Microenvironment
chemical_list: D014408:Biomarkers, Tumor; D010100:Oxygen
keywords: Clinical oximetry; Comparative effectiveness; Cost effectiveness; EPR (electron paramagnetic resonance); Tumor hypoxia