title: Clinical implication of long noncoding RNA 91H expression profile in osteosarcoma patients.
abstract: Long noncoding RNAs have been documented as having widespread roles in carcinogenesis and cancer progression. However, roles of long noncoding RNAs in osteosarcoma remain unclear. This study is to investigate the clinical relevance and biological functions of long noncoding RNA 91H in osteosarcoma. Herein, we confirmed that 91H expression was notably increased in osteosarcoma patients and cell lines compared to healthy controls and normal human bone cell lines. High expression of 91H was significantly correlated with advanced clinical stage, chemotherapy after surgery, and tumor size >5 cm. Furthermore, 91H was an independent prognostic factor for overall survival in osteosarcoma patients after treatments. Additionally, the knockdown of 91H expression inhibited osteosarcoma cells' proliferation and promoted their apoptosis in vitro. In summary, these findings indicate that 91H may be a novel biomarker for risk prognostication and also provide a clue to the molecular etiology of osteosarcoma.
authors.affiliation: Department of Nephrology.
authors.forename: Wen-Kai
authors.initials: WK
authors.lastname: Xia
authors.affiliation: Department of Oncology, The Affiliated Jiangyin Hospital, School of Medicine, Southeast University, Jiangyin, Jiangsu, People's Republic of China.
authors.forename: Qing-Feng
authors.initials: QF
authors.lastname: Lin
authors.affiliation: Department of Oncology, The Affiliated Jiangyin Hospital, School of Medicine, Southeast University, Jiangyin, Jiangsu, People's Republic of China.
authors.forename: Dong
authors.initials: D
authors.lastname: Shen
authors.affiliation: Department of Oncology, The Affiliated Jiangyin Hospital, School of Medicine, Southeast University, Jiangyin, Jiangsu, People's Republic of China.
authors.forename: Zhi-Li
authors.initials: ZL
authors.lastname: Liu
authors.affiliation: Department of Oncology, The Affiliated Jiangyin Hospital, School of Medicine, Southeast University, Jiangyin, Jiangsu, People's Republic of China.
authors.forename: Jun
authors.initials: J
authors.lastname: Su
authors.affiliation: Department of Oncology, The Affiliated Jiangyin Hospital, School of Medicine, Southeast University, Jiangyin, Jiangsu, People's Republic of China.
authors.forename: Wei-Dong
authors.initials: WD
authors.lastname: Mao
keywords: 91H; long noncoding RNA; osteosarcoma; survival