title: l-Isoleucine in a Choline Chloride/Ethylene Glycol Deep Eutectic Solvent: A Reusable Reaction Kit for the Asymmetric Cross-Aldol Carboligation.
abstract: l-Isoleucine is able to catalyze the cross-aldol reaction between cyclohexanone and aromatic aldehydes in a deep eutectic solvent consisting in choline chloride and ethylene glycol, rendering products with high diatereo- and enantioselectivity. This protocol is straightforward and green: the organocatalyst and the reaction medium can be recycled up to five times, allowing the preparation of different substrates with a single load of solvent and catalyst.
authors.affiliation: Departamento de Química Orgánica e Inorgánica, Universidad de Oviedo , C/Julián Clavería 8, 33006 Oviedo, Spain.
authors.forename: Noé
authors.initials: N
authors.lastname: Fanjul-Mosteirín
authors.affiliation: Departamento de Química Orgánica e Inorgánica, Universidad de Oviedo , C/Julián Clavería 8, 33006 Oviedo, Spain.
authors.forename: Carmen
authors.initials: C
authors.lastname: Concellón
authors.affiliation: Departamento de Química Orgánica e Inorgánica, Universidad de Oviedo , C/Julián Clavería 8, 33006 Oviedo, Spain.
authors.forename: Vicente
authors.initials: V
authors.lastname: Del Amo