title: Pancreatic Adenocarcinoma Complicated by Sinistral Portal Hypertension.
abstract: Pancreatic cancer is known for vague symptoms that lead to a delay in diagnosis, and hence most cases are found at an advanced stage. Many complications can happen secondary to pancreatic cancer including diabetes, malabsorption, and deep venous thrombosis. Sinistral (segmental or left-sided) portal hypertension (SPH) refers to portal hypertension confined to the left-sided segment of the portal venous system namely the splenic side, and the most common etiology is splenic vein thrombosis (SVT). We present here a case of a 66-year-old male with advanced pancreatic cancer who died due to bleeding secondary to SVT. We advise physicians caring for these patients to be aware of this complication, which may also be the manifestation of an undiagnosed pancreatic cancer.
authors.affiliation: Hematology/Oncology, Tufts Medical Center.
authors.forename: Muhammad W
authors.initials: MW
authors.lastname: Saif
authors.affiliation: Yale School of Medicine, Yale University.
authors.forename: Kristin
authors.initials: K
authors.lastname: Kaley
authors.affiliation: Yale School of Medicine, Yale University.
authors.forename: Lynne
authors.initials: L
authors.lastname: Lamb
keywords: deep venous thrombosis; non-cirrhotic portal hypertension; portal hypertension; splenic hypertension; variceal bleed