title: Chemoselective Conversion from α-Hydroxy Acids to α-Keto Acids Enabled by Nitroxyl-Radical-Catalyzed Aerobic Oxidation.
abstract: The chemoselective oxidation of α-hydroxy acids to α-keto acids catalyzed by 2-azaadamantane N-oxyl (AZADO), a nitroxyl radical catalyst, is described. Although α-keto acids are labile and can easily release CO2 under oxidation conditions, the use of molecular oxygen as a cooxidant enables the desired chemoselective oxidation.
authors.affiliation: Department of Basic Medicinal Sciences, Graduate School of Pharmaceutical Sciences, Nagoya University , Furo-cho, Chikusa, Nagoya 464-8601, Japan.
authors.forename: Keisuke
authors.initials: K
authors.lastname: Furukawa
authors.affiliation: Department of Basic Medicinal Sciences, Graduate School of Pharmaceutical Sciences, Nagoya University , Furo-cho, Chikusa, Nagoya 464-8601, Japan.
authors.forename: Haruki
authors.initials: H
authors.lastname: Inada
authors.affiliation: Department of Basic Medicinal Sciences, Graduate School of Pharmaceutical Sciences, Nagoya University , Furo-cho, Chikusa, Nagoya 464-8601, Japan.
authors.forename: Masatoshi
authors.initials: M
authors.lastname: Shibuya
authors.affiliation: Department of Basic Medicinal Sciences, Graduate School of Pharmaceutical Sciences, Nagoya University , Furo-cho, Chikusa, Nagoya 464-8601, Japan.
authors.forename: Yoshihiko
authors.initials: Y
authors.lastname: Yamamoto