title: The polymorphism G4C14-to-A4T14 in p73 gene may affect the susceptibility to male infertility with severe spermatogenesis impairment in Chinese population.
abstract: OBJECTIVE
  The aim of this study was to explore the association between the polymorphism G4C14-to-A4T14 in the p73 gene and male infertility with severe spermatogenesis impairment in Chinese population.
  
  
  METHODS
  Three hundreds and one infertile patients with severe spermatogenesis impairment (including azoospermia and severe oligospermia) and 252 fertile men were recruited in this study. The polymorphism G4C14-to-A4T14 in the p73 gene was genotyped using polymerase chain reaction and restriction fragment length polymorphism assay. The differences in allelic and genotypic frequencies between patients and controls were evaluated by chi-square test.
  
  
  RESULTS
  The frequency of allele AT (28.9% vs. 22.4%, P=0.017, OR=1.41, 95% CI=1.07-1.85) in patients with severe spermatogenesis impairment was significantly higher than that in controls, whereas the genotype GC/GC was significantly decreased in patients compared with controls (48.5% vs. 59.1%, P=0.048, OR=0.65, 95% CI=0.46-0.91).
  
  
  CONCLUSIONS
  The findings of this study suggested that the polymorphism G4C14-to-A4T14 in p73 gene might be associated with severe spermatogenesis impairment and could affect the susceptibility to male infertility with severe spermatogenesis impairment in Chinese population.
authors.affiliation: College of Basic Medicine, Dali University, Dali, 671000, China.
authors.forename: Ting
authors.initials: T
authors.lastname: Xie
authors.affiliation: College of Basic Medicine, Dali University, Dali, 671000, China; Department of Reproductive Medicine, Affiliated Hospital of Dali University, Dali, 671000, China.
authors.forename: Cheng-He
authors.initials: CH
authors.lastname: Yu
authors.affiliation: Department of Genetics, College of Agriculture and Biology, Dali University, Dali, 671003, China.
authors.forename: Ye
authors.initials: Y
authors.lastname: Zheng
authors.affiliation: College of Basic Medicine, Dali University, Dali, 671000, China; Department of Genetics, College of Agriculture and Biology, Dali University, Dali, 671003, China. Electronic address: azhoucun@163.com.
authors.forename: Zhou-Cun
authors.initials: ZC
authors.lastname: A
mesh_terms: D000328:Adult; D000483:Alleles; D044466:Asian People / Q000235:genetics; D002681:China; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D007248:Infertility, Male / Q000235:genetics*; D008297:Male; D020641:Polymorphism, Single Nucleotide; D013091:Spermatogenesis / Q000235:genetics*; D000072160:Tumor Protein p73 / Q000235:genetics*
chemical_list: C000606460:TP73 protein, human; D000072160:Tumor Protein p73
keywords: Male infertility; Polymorphism; Spermatogenesis impairment; p73