title: Modifying the infant's diet to prevent food allergy.
abstract: Recommendations and guidelines on the prevention of food allergy have changed in recent decades. The aim of this review of the current evidence and ongoing studies is to provide a comprehensive and up to date picture of prevention of food allergy for healthcare professionals. The review was undertaken as part of the European Union funded Integrated Approaches to Food Allergy and Allergen Management (iFAAM) study. This is a wide ranging project bringing together expertise across the breadth of food allergy research. Specifically, the review discusses dietary manipulation in food allergy prevention, and covers the possible preventive strategies of allergen avoidance, early allergen introduction, general nutrition and supplements, as well as other strategies, such as prebiotics and probiotics. The review concludes that despite agreement that allergen avoidance strategies should not be undertaken for allergy prevention, there is currently no consensus regarding what actions should be recommended beyond exclusive breastfeeding for the first 4-6 months of life. Recent and upcoming trial results, which are detailed in this review, should help inform the debate and add clarity to the topic.
authors.affiliation: Clinical and Experimental Sciences and Human Development in Health Academic Unit, Faculty of Medicine, University of Southampton, Southampton, UK.
authors.forename: Kate
authors.identifier: http://orcid.org/0000-0003-3649-7963
authors.initials: K
authors.lastname: Grimshaw
authors.affiliation: Guy's and St Thomas' NHS Foundation Trust, London, UK.
authors.forename: Kirsty
authors.initials: K
authors.lastname: Logan
authors.affiliation: Vitamin D Research Group, School of Food and Nutritional Science, University College Cork, Cork, Ireland.
authors.forename: Sinead
authors.initials: S
authors.lastname: O'Donovan
authors.affiliation: Vitamin D Research Group, School of Food and Nutritional Science, University College Cork, Cork, Ireland.|The Irish Centre for Fetal and Neonatal Translational Research, University College Cork, Cork, Ireland.
authors.forename: Mairead
authors.initials: M
authors.lastname: Kiely
authors.affiliation: INRA_UIAA, Gif sur Yvette, France.
authors.forename: Karine
authors.initials: K
authors.lastname: Patient
authors.affiliation: TNO, Zeist, The Netherlands.
authors.forename: Jolanda
authors.initials: J
authors.lastname: van Bilsen
authors.affiliation: Charite-Universitatsmedizin Berlin, Department of Paediatric Pneumology & Immunology, Berlin, Germany.
authors.forename: Kirsten
authors.initials: K
authors.lastname: Beyer
authors.affiliation: Department of Allergy and Immunology, Children's Hospital Westmead, Sydney University, Sydney, New South Wales, Australia.
authors.forename: Dianne E
authors.initials: DE
authors.lastname: Campbell
authors.affiliation: Respiratory Epidemiology, Occupational Medicine and Public Health Group, National Heart and Lung Institute, Imperial College, London, UK.
authors.forename: Vanessa
authors.initials: V
authors.lastname: Garcia-Larsen
authors.affiliation: Charite-Universitatsmedizin Berlin, Institute for Social Medicine, Epidemiology and Health Economics, Berlin, Germany.
authors.forename: Linus
authors.initials: L
authors.lastname: Grabenhenrich
authors.affiliation: Guy's and St Thomas' NHS Foundation Trust, London, UK.|King's College London, MRC and Asthma UK Centre in Allergic Mechanisms of Asthma, Division of Asthma, Allergy and Lung Biology, UK.
authors.forename: Gideon
authors.initials: G
authors.lastname: Lack
authors.affiliation: Institute of Inflammation and Repair, Manchester Academic Health Science Centre, Manchester Institute of Biotechnology, The University of Manchester, Manchester, UK.
authors.forename: Clare
authors.initials: C
authors.lastname: Mills
authors.affiliation: INRA AgroParisTech, Gif sur Yvette, Paris, France.
authors.forename: Jean-Michel
authors.initials: JM
authors.lastname: Wal
authors.affiliation: Clinical and Experimental Sciences and Human Development in Health Academic Unit, Faculty of Medicine, University of Southampton, Southampton, UK.|NIHR Southampton Respiratory Biomedical Research Unit, University Hospital Southampton NHS Foundation Trust, Southampton, UK.
authors.forename: Graham
authors.initials: G
authors.lastname: Roberts
mesh_terms: D000485:Allergens / Q000009:adverse effects; D000975:Antioxidants / Q000008:administration & dosage; D004035:Diet Therapy / Q000379:methods*; D005512:Food Hypersensitivity / Q000178:diet therapy / Q000517:prevention & control*; D006801:Humans; D007073:Immunoglobulin E / Q000009:adverse effects; D007223:Infant; D041943:Infant Formula; D018977:Micronutrients / Q000008:administration & dosage; D064887:Observational Studies as Topic; D056692:Prebiotics / Q000008:administration & dosage; D011322:Primary Prevention; D019936:Probiotics / Q000008:administration & dosage; D016032:Randomized Controlled Trials as Topic; D055502:Secondary Prevention; D014807:Vitamin D / Q000008:administration & dosage; D014815:Vitamins / Q000008:administration & dosage
chemical_list: D000485:Allergens; D000975:Antioxidants; D018977:Micronutrients; D056692:Prebiotics; D014815:Vitamins; D014807:Vitamin D; D007073:Immunoglobulin E
keywords: Allergy; Infant Feeding; Nutrition; prevention