title: Infection dynamics in a traveller with persistent shedding of Zika virus RNA in semen for six months after returning from Haiti to Italy, January 2016.
abstract: We describe the dynamics of Zika virus (ZIKV) infection in a man in his early 40s who developed fever and rash after returning from Haiti to Italy, in January 2016. Follow-up laboratory testing demonstrated detectable ZIKV RNA in plasma up to day 9 after symptom onset and in urine and saliva up to days 15 and 47, respectively. Notably, persistent shedding of ZIKV RNA was demonstrated in semen, still detectable at 181 days after onset.
authors.affiliation: Department of Molecular Medicine, University of Padova, Padova, Italy.
authors.forename: Luisa
authors.initials: L
authors.lastname: Barzon
authors.forename: Monia
authors.initials: M
authors.lastname: Pacenti
authors.forename: Elisa
authors.initials: E
authors.lastname: Franchin
authors.forename: Enrico
authors.initials: E
authors.lastname: Lavezzo
authors.forename: Marta
authors.initials: M
authors.lastname: Trevisan
authors.forename: Dino
authors.initials: D
authors.lastname: Sgarabotto
authors.forename: Giorgio
authors.initials: G
authors.lastname: Palù
mesh_terms: D000328:Adult; D000914:Antibodies, Viral / Q000097:blood; D005076:Exanthema / Q000821:virology; D005334:Fever / Q000821:virology*; D006205:Haiti; D006801:Humans; D007075:Immunoglobulin M / Q000097:blood; D007558:Italy; D012367:RNA, Viral / Q000097:blood* / Q000235:genetics / Q000652:urine; D020133:Reverse Transcriptase Polymerase Chain Reaction; D012463:Saliva / Q000821:virology*; D012661:Semen / Q000737:chemistry* / Q000821:virology; D055101:Semen Analysis; D017423:Sequence Analysis, RNA; D014195:Travel; D014556:Urine / Q000821:virology; D019562:Viral Load; D017201:Virus Shedding; D000071244:Zika Virus / Q000235:genetics / Q000302:isolation & purification*; D000071243:Zika Virus Infection / Q000097:blood / Q000175:diagnosis* / Q000821:virology
chemical_list: D000914:Antibodies, Viral; D007075:Immunoglobulin M; D012367:RNA, Viral
keywords: emerging or re-emerging diseases; imported viral diseases; laboratory surveillance; molecular methods; sexually transmitted infections; vector-borne infections