title: [Karyomegalic interstitial nephritis: an atypical case].
abstract: Karyomegalic interstitial nephritis (KIN) is a rare disease entity that was first described by Burry in 1974. The prevalence of this disease is less than 1% and its pathogenesis is unclear. KIN is characterized by chronic tubulointerstitial nephritis associated with enlarged tubular epithelial cell nuclei, which leads to progressive decline of renal function. The disease has no known treatment. Here, we report on a 50-year-old female patient who presented with asymptomatic progressive decline of renal function. Renal biopsy demonstrated chronic tubulointerstitial nephritis with markedly enlarged and hyperchromic nuclei of tubule epithelial cells the hallmark of karyomegalic nephritis. Clinical and pathologic findings of this case are discussed in light of the available literature.
authors.forename: Mauro
authors.initials: M
authors.lastname: Dugo
authors.forename: Licia
authors.initials: L
authors.lastname: Laurino
authors.forename: Annalisa
authors.initials: A
authors.lastname: Di Martino
authors.forename: Anna
authors.initials: A
authors.lastname: Brunello
authors.forename: Adriana
authors.initials: A
authors.lastname: Caberlotto
authors.forename: Pierluigi
authors.initials: P
authors.lastname: Gatti
authors.forename: Margherita
authors.initials: M
authors.lastname: Mangino
authors.forename: Stefania
authors.initials: S
authors.lastname: Mastrosimone
authors.forename: Alessandra
authors.initials: A
authors.lastname: Pasi
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Palminteri
authors.forename: Riccarda
authors.initials: R
authors.lastname: Puggia
authors.forename: Monica
authors.initials: M
authors.lastname: Rizzolo
authors.forename: Katia
authors.initials: K
authors.lastname: Toffolo
authors.forename: Bice
authors.initials: B
authors.lastname: Virgilio
authors.forename: Riccardo
authors.initials: R
authors.lastname: Zagatti
authors.forename: Maria Cristina
authors.initials: MC
authors.lastname: Maresca
mesh_terms: D002467:Cell Nucleus / Q000473:pathology*; D002908:Chronic Disease; D005260:Female; D006801:Humans; D008875:Middle Aged; D009395:Nephritis, Interstitial / Q000473:pathology*