title: GENE PROFILING: IMPLICATIONS IN DERMATOLOGY.
abstract: DNA microarrays are capable of following the level of expression of, virtually, all genes in a human tissue. This has been employed to determine the aberrant gene expression profiles in many skin diseases, including ultraviolet light damage, inflammatory processes and cancers. Because of its accessibility, skin also served as one of the initial targets of basic research using DNA microarrays. Both the epidermis and dermis have been extensively investigated. Development of bed-side uses of DNA arrays, and the concomitant price reduction of the materials and methods of microarray analyses, holds great promise for improved diagnosis, treatment and prevention of dermatologic disorders.
authors.affiliation: Departments of Dermatology and Biochemistry, and the NYU Cancer Institute, New York University School of Medicine, 550 First Avenue, New York, NY, 10016 USA, 212 263-5924.
authors.forename: Miroslav
authors.initials: M
authors.lastname: Blumenberg
authors.affiliation: Hospital for Special Surgery, Tissue Repair Lab, Tissue Engineering, Regeneration and Repair Program, 535 E 70 Street, New York, NY 10021 USA; Department of Dermatology, Weill Medical College of the Cornell University, 1300 York Avenue, New York, NY 10021, USA, 212 774-7160.
authors.forename: Marjana
authors.initials: M
authors.lastname: Tomic-Canic
keywords: DNA microarrays; UV light; cytokines; melanoma; psoriasis; transcriptional profiling