title: The Significance of Hypothermia in Abdominal Aortic Aneurysm Repair.
abstract: BACKGROUND
  The aim of this study was to review the literature on the association between hypothermia and outcomes in open and endovascular abdominal aortic aneurysm (AAA) repair. The secondary aim was to determine whether there is a difference in body temperature in patients undergoing either transperitoneal (TP), retroperitoneal (RP), or endovascular surgical repair of the abdominal aorta (EVAR).
  
  
  METHODS
  MEDLINE, Web of Science, and Trip searched for all studies on temperature in the context of aortic surgery or endovascular aortic interventions. To be included in the review, the papers had to be related to intraoperative or postoperative hypothermia and/or normothermia, with regards to either open or endovascular repair of the abdominal aorta. Thoracic or thoracoabdominal aortic repairs were not included for review.
  
  
  RESULTS
  Eight studies involving 765 patients were eligible. Of these, 6 studies looked at open elective AAA repair involving 605 patients. Only 2 studies investigated emergency AAA repair and consisted of 160 patients where only 35 of those patients underwent emergency EVAR. Normothermic patients had a shorter length of stay in the intensive care unit (P = 0.0008), while hypothermia was independently associated with higher rates of organ dysfunction, in-hospital mortality, and prolonged hospital length of stay. In ruptured AAAs, the lowest average intraoperative temperature was recorded in open repair compared with EVAR (P = 0.02). There was no statistically significant difference in postoperative temperature between patients undergoing elective RP repair and those having TP surgery.
  
  
  CONCLUSIONS
  The studies identified in this review have shown that hypothermia has numerous deleterious effects on outcomes in AAA repair - whether or not these adverse outcomes are those such as higher rates of organ dysfunction, mortality or prolonged hospital length of stay, can only be done at the single paper level and not at a literature review level, due to multiple confounding variables. Despite these limitations, the benefits of this review are numerous. This article highlights the importance of core body temperature and outcomes of AAA repair. Furthermore, it brings forth the need to standardize the method of core body temperature measurement and method of rewarming. Given the body of evidence so far, these standardized data collection points will be important for national vascular quality improvement initiatives. Only through rigorous analysis of standardized dataset can firm recommendation regarding peri- and postoperative temperature management be made.
authors.affiliation: Department of Vascular Surgery, University Hospital of Wales, Heath Park, Cardiff, United Kingdom.
authors.forename: Georgiana
authors.initials: G
authors.lastname: Samoila
authors.affiliation: Department of Vascular Surgery, Royal Glamorgan Hospital, Llantrisant, United Kingdom.
authors.forename: Richard T
authors.initials: RT
authors.lastname: Ford
authors.affiliation: Department of Vascular Surgery, University Hospital of Wales, Heath Park, Cardiff, United Kingdom.
authors.forename: James C
authors.initials: JC
authors.lastname: Glasbey
authors.affiliation: Department of Vascular Surgery, Royal Glamorgan Hospital, Llantrisant, United Kingdom.
authors.forename: Michael H
authors.initials: MH
authors.lastname: Lewis
authors.affiliation: Department of Vascular Surgery, Royal Gwent Hospital, Newport, United Kingdom.
authors.forename: Christopher P
authors.initials: CP
authors.lastname: Twine
authors.affiliation: Department of Vascular Surgery, University Hospital of Wales, Heath Park, Cardiff, United Kingdom. Electronic address: Ian.Williams5@wales.nhs.uk.
authors.forename: Ian M
authors.initials: IM
authors.lastname: Williams
mesh_terms: D017544:Aortic Aneurysm, Abdominal / Q000175:diagnosis / Q000401:mortality / Q000503:physiopathology / Q000601:surgery*; D001833:Body Temperature Regulation; D057510:Endovascular Procedures / Q000009:adverse effects* / Q000401:mortality; D017052:Hospital Mortality; D006801:Humans; D007035:Hypothermia / Q000175:diagnosis / Q000209:etiology* / Q000401:mortality / Q000503:physiopathology; D007902:Length of Stay; D012307:Risk Factors; D013997:Time Factors; D016896:Treatment Outcome; D014656:Vascular Surgical Procedures / Q000009:adverse effects* / Q000401:mortality