title: Enhanced Cognitive Effects of Demethoxycurcumin, a Natural Derivative of Curcumin on Scopolamine-Induced Memory Impairment in Mice.
abstract: In the present study, we examined the ameliorating effects of demethoxycurcumin (DMC) on memory impairment induced by scopolamine using passive avoidance and Morris water maze tests in mice. Moreover, to determine the neurobiological effects underlying the ameliorating effects of the DMC, choline acetyltransferase (ChAT) immunoreactivity was evaluated in mice exposed to scopolamine. Our results demonstrated that chronic oral administration (28 days) of DMC (10 mg/kg) improved scopolamine-induced learning impairment in the passive avoidance task and memory impairment in the Morris water maze. Moreover, Choline acetyltransferase (ChAT) activity in the DMC-treated group was significantly increased to 33.03% compared with the control group. Our present finding suggests that DMC ameliorates memory impairments induced by scopolamine treatment through reversing the reduction of hippocampal ChAT expression in mice.
authors.affiliation: Research Group of Innovative Special Food, Korea Food Research Institute, Seongnam 13539, Korea. neodw4015@kfri.re.kr.
authors.forename: Dong Wook
authors.initials: DW
authors.lastname: Lim
authors.affiliation: Research Group of Innovative Special Food, Korea Food Research Institute, Seongnam 13539, Korea. Son.Hyun-jung@kfri.re.kr.
authors.forename: Hyun Jung
authors.initials: HJ
authors.lastname: Son
authors.affiliation: Research Group of Innovative Special Food, Korea Food Research Institute, Seongnam 13539, Korea. myum@kfri.re.kr.|Division of Food Biotechnology, University of Science & Technology, Daejeon 34113, Korea. myum@kfri.re.kr.
authors.forename: Min Young
authors.initials: MY
authors.lastname: Um
authors.affiliation: Research Group of Innovative Special Food, Korea Food Research Institute, Seongnam 13539, Korea. skihs@kfri.re.kr.
authors.forename: In-Ho
authors.initials: IH
authors.lastname: Kim
authors.affiliation: Research Group of Innovative Special Food, Korea Food Research Institute, Seongnam 13539, Korea. imissu@kfri.re.kr.
authors.forename: Daeseok
authors.initials: D
authors.lastname: Han
authors.affiliation: Research Group of Innovative Special Food, Korea Food Research Institute, Seongnam 13539, Korea. smcho@kfri.re.kr.
authors.forename: Suengmok
authors.initials: S
authors.lastname: Cho
authors.affiliation: Research Group of Innovative Special Food, Korea Food Research Institute, Seongnam 13539, Korea. chang@kfri.re.kr.
authors.forename: Chang-Ho
authors.initials: CH
authors.lastname: Lee
mesh_terms: D000284:Administration, Oral; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects*; D002795:Choline O-Acetyltransferase / Q000378:metabolism; D003474:Curcumin / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology; D036381:Diarylheptanoids; D004195:Disease Models, Animal; D004334:Drug Administration Schedule; D005786:Gene Expression Regulation / Q000187:drug effects; D008297:Male; D018782:Maze Learning / Q000187:drug effects*; D008569:Memory Disorders / Q000139:chemically induced / Q000188:drug therapy* / Q000378:metabolism; D051379:Mice; D008813:Mice, Inbred ICR; D012601:Scopolamine / Q000009:adverse effects*
chemical_list: D036381:Diarylheptanoids; D012601:Scopolamine; D002795:Choline O-Acetyltransferase; D003474:Curcumin; C050229:demethoxycurcumin
keywords: Morris water maze; acetyltransferase; demethoxycurcumin; passive avoidance task; scopolamine