title: False Suggestion of Malignant Transformation of Benign Bone Tumor by 18F-FDG PET/CT: A Potential Pitfall.
abstract: A 68-year-old man underwent serial F-FDG PET/CT scan follow-up for lung cancer. Then 5.5 years after the initial F-FDG PET/CT scan, the presumed benign bone tumor in the left clavicle showed markedly increased FDG uptake during follow-up; in contrast, the Tc-MDP bone scan paradoxically exhibited no apparent interval change since last bone scan 5.5 years earlier. He underwent a CT-guided biopsy, and the pathological diagnosis was benign fibrous histiocytoma. The result was consistent with the lack of progression in Tc-MDP bone scan, whereas the F-FDG PET/CT scan gave a false-positive impression of malignant transformation.
authors.affiliation: From the *Department of Nuclear Medicine and PET Center, China Medical University Hospital, Taichung City; †China Medical University, Taichung City; ‡Department of Radiation Oncology, Changhua Show Chwan Memorial Hospital, Changhua County; §Department of Radiation Oncology, China Medical University Hospital, Taichung City; ∥Department of Radiology, China Medical University Hospital, Taichung City; ¶Department of Biomedical Imaging and Radiological Science, China Medical University, Taichung City; and **School of Medicine, China Medical University, Taichung City, Taiwan.
authors.forename: Yu-Ren
authors.initials: YR
authors.lastname: Chen
authors.forename: Yu-Cheng
authors.initials: YC
authors.lastname: Kuo
authors.forename: Cheng-Nan
authors.initials: CN
authors.lastname: Hsu
authors.forename: Te-Chun
authors.initials: TC
authors.lastname: Hsieh
authors.forename: Chia-Hung
authors.initials: CH
authors.lastname: Kao
mesh_terms: D001859:Bone Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology* / Q000556:secondary; D002471:Cell Transformation, Neoplastic; D005189:False Positive Reactions; D019788:Fluorodeoxyglucose F18; D006801:Humans; D008175:Lung Neoplasms / Q000473:pathology; D008297:Male; D008875:Middle Aged; D000072078:Positron Emission Tomography Computed Tomography
chemical_list: D019788:Fluorodeoxyglucose F18