title: Potential factors involved in the causation of rhabdomyolysis following status asthmaticus.
abstract: Rhabdomyolysis is a rare but potentially fatal complication of status asthmaticus. Since the first case was reported in 1978, only a few dozen cases have been described till date. We performed a literature review with the aim to characterize the pathophysiological basis of the occurrence of rhabdomyolysis in patients with status asthmaticus. Excessive exertion of respiratory muscles, hypoxia and acidosis, electrolyte imbalance, infections, some drugs used for asthma control, use of mechanical ventilation, prolonged cardiopulmonary resuscitation, higher age of the patient and some underlying diseases or genetic factors appear to be involved in its causation. In patients with status asthmaticus, it is important to pay more attention to these factors and to closely monitor creatine kinase levels in blood so as to ensure early detection of rhabdomyolysis.
authors.affiliation: Department of Pediatrics, The First Hospital of Jilin University, Xinmin street 71#, Changchun, 130021 Jilin Province People's Republic of China.
authors.forename: Hongmei
authors.initials: H
authors.lastname: Qiao
authors.affiliation: Department of Pediatrics, The First Hospital of Jilin University, Xinmin street 71#, Changchun, 130021 Jilin Province People's Republic of China.
authors.forename: Huanji
authors.initials: H
authors.lastname: Cheng
authors.affiliation: Department of Pediatrics, The First Hospital of Jilin University, Xinmin street 71#, Changchun, 130021 Jilin Province People's Republic of China.
authors.forename: Li
authors.initials: L
authors.lastname: Liu
authors.affiliation: Department of Pediatrics, The First Hospital of Jilin University, Xinmin street 71#, Changchun, 130021 Jilin Province People's Republic of China.
authors.forename: Jianing
authors.initials: J
authors.lastname: Yin
keywords: Mechanical ventilation; Medication; Respiratory muscle exertion; Rhabdomyolysis; Risk factors; Status asthmaticus