title: Fabrication of magnetite nano particles and modification with metal organic framework of Zn(2+) for sorption of doxycyline.
abstract: This study presents a novel method for synthesis and characterization of a metal-organic framework and application in drug delivery. The first step was synthesis of amino functionalized magnetite that was then modified by a metal-organic framework of Zn(2+). This newly developed nano-sorbent was characterized by Fourier transform infrared spectroscopy, scanning electron microscopy, energy dispersive x-ray spectroscopy, thermogravimetric analysis, vibrating sample magnetometer and x-ray diffraction. Doxycycline was loaded to the nano-sorbent and effects of the variable parameters, kinetics of adsorption, release and capacity of adsorption were investigated. Test results specified maximum sorption of 21.5mgg(-1) for doxycycline in conditions of nano-sorbent at pH 7 and optimum time of 10min. Equilibrium adsorption data were analyzed by the Langmuir, Freundlich and Temkin models. Results showed that about 40% of doxycycline was released in simulated gastric fluid for the 30min and more than 70% was released in simulated intestinal fluid during 12h. These results were satisfactory and demonstrate that this new nano-sorbent modified with metal-organic framework had a good level of efficiency for drug delivery of doxycycline.
authors.affiliation: Department of Chemistry, Karaj Branch, Islamic Azad University, Karaj, Iran.
authors.forename: Mahsa
authors.initials: M
authors.lastname: Ghassemi Nooreini
authors.affiliation: Department of Chemistry, Central Tehran Branch, Islamic Azad University, Tehran, Iran. Electronic address: h.ahmadpanahi@iauctb.ac.ir.
authors.forename: Homayon
authors.initials: H
authors.lastname: Ahmad Panahi
mesh_terms: D004318:Doxycycline / Q000737:chemistry* / Q000493:pharmacokinetics*; D065546:Drug Liberation; D005662:Furaldehyde / Q000737:chemistry; D058185:Magnetite Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D012822:Silicon Dioxide / Q000737:chemistry; D015032:Zinc / Q000737:chemistry*
chemical_list: D058185:Magnetite Nanoparticles; D012822:Silicon Dioxide; D005662:Furaldehyde; D015032:Zinc; D004318:Doxycycline
keywords: Doxycycline; Drug delivery; Magnetic nano particles; Metal organic framework; Modification