title: Pubinernoid A and Apo-9'-fucoxanthinone, Secondary Metabolites from a Gorgonian Coral Pinnigorgia sp.
abstract: The structures of pubinernoid A (1) and apo-9'-fucoxanthinone (2), isolated from a gorgonian coral Pinnigorgia sp., were elucidated on the basis of spectroscopic analysis and by comparison of their spectroscopic data with those of known compounds. This is the first report of 1 and 2 from an animal source. Apo-9'-fucoxanthinone (2) displayed a significant inhibitory effect on the release of elastase by human neutrophils, with an IC50 value of 5.75 μM.
authors.forename: Hsin-Huan
authors.initials: HH
authors.lastname: Chang
authors.forename: Yu-Chia
authors.initials: YC
authors.lastname: Chang
authors.forename: Wu-Fu
authors.initials: WF
authors.lastname: Chen
authors.forename: Tsong-Long
authors.initials: TL
authors.lastname: Hwang
authors.forename: Lee-Shing
authors.initials: LS
authors.lastname: Fang
authors.forename: Zhi-Hong
authors.initials: ZH
authors.lastname: Wen
authors.forename: Yu-Hsin
authors.initials: YH
authors.lastname: Chen
authors.forename: Yang-Chang
authors.initials: YC
authors.lastname: Wu
authors.forename: Ping-Jyun
authors.initials: PJ
authors.lastname: Sung
mesh_terms: D000818:Animals; D037421:Anthozoa / Q000737:chemistry* / Q000378:metabolism; D006801:Humans; D015394:Molecular Structure; D009504:Neutrophils / Q000187:drug effects / Q000201:enzymology; D010196:Pancreatic Elastase / Q000032:analysis / Q000378:metabolism; D064210:Secondary Metabolism; D013729:Terpenes / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology
chemical_list: D013729:Terpenes; C000610945:apo-9'-fucoxanthinone; C000610946:pubinernoid A; D010196:Pancreatic Elastase