title: Definitive Radiotherapy for Squamous Cell Carcinoma of the Glottic Larynx.
abstract: BACKGROUND
  Depending on the extent of disease, squamous cell carcinoma (SCC) of the glottis is managed with surgery, radiotherapy (RT), or a combination of these modalities. Patients with advanced disease may receive concomitant chemotherapy in conjunction with definitive or postoperative RT.
  
  
  METHODS
  The treatment policies of the University of Florida and patient outcomes are reviewed.
  
  
  RESULTS
  The likelihood of cure after RT for carcinoma in situ (Tis) to T2 glottic SCC varies from 70% to 94% depending on tumor stage. Consideration should be given to adding weekly cisplatin for patients with T2b SCC because of the high local recurrence rate after RT alone. The probability of cure is about 65% to 80% for select low-volume (≤ 3.5 cc) T3 to T4 glottic SCC after RT. These patients should be considered for concomitant weekly cisplatin. Higher-volume tumors, particularly those with airway compromise, should be treated with laryngectomy and postoperative RT.
  
  
  CONCLUSIONS
  Definitive RT is an excellent treatment for select patients with laryngeal cancer.
authors.affiliation: Departments of Radiation Oncology, University of Florida College of Medicine, Gainesville, FL 32610-0385, USA. mendwm@shands.ufl.edu.
authors.forename: William M
authors.initials: WM
authors.lastname: Mendenhall
authors.forename: Roi
authors.initials: R
authors.lastname: Dagan
authors.forename: Curtis M
authors.initials: CM
authors.lastname: Bryant
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Amdur
authors.forename: Anthony A
authors.initials: AA
authors.lastname: Mancuso
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000473:pathology / Q000532:radiotherapy* / Q000601:surgery; D005260:Female; D005931:Glottis / Q000473:pathology*; D006801:Humans; D007822:Laryngeal Neoplasms / Q000473:pathology / Q000532:radiotherapy* / Q000601:surgery; D008297:Male; D016896:Treatment Outcome