title: Diagnostic Criteria, Classification and Treatment Goals in Multiple Sclerosis: The Chronicles of Time and Space.
abstract: Multiple sclerosis (MS) is one of the most diverse human diseases. Since its first description by Charcot in the nineteenth century, the diagnostic criteria, clinical course classification, and treatment goals for MS have been constantly revised and updated to improve diagnostic accuracy, physician communication, and clinical trial design. These changes have improved the clinical outcomes and quality of life for patients with the disease. Recent technological and research breakthroughs will almost certainly further change how we diagnose, classify, and treat MS in the future. In this review, we summarize the key events in the history of MS, explain the reasoning behind the current criteria for MS diagnosis, classification, and treatment, and provide suggestions for further improvements that will keep enhancing the clinical practice of MS.
authors.affiliation: Department of Neurology, Icahn School of Medicine at Mount Sinai, 1428 Madison Ave, New York, NY, 10029, USA. achilles.ntranos@gmail.com.
authors.forename: Achilles
authors.initials: A
authors.lastname: Ntranos
authors.affiliation: Department of Neurology, Icahn School of Medicine at Mount Sinai, 1428 Madison Ave, New York, NY, 10029, USA.|Corinne Goldsmith Dickinson Center for MS, Icahn School of Medicine at Mount Sinai, 5 East 98th Street, 1st Floor, New York, NY, 10029-6574, USA.
authors.forename: Fred
authors.initials: F
authors.lastname: Lublin
mesh_terms: D006801:Humans; D009103:Multiple Sclerosis / Q000145:classification / Q000175:diagnosis / Q000628:therapy
keywords: Clinical decision-making; Early diagnosis; History; Multiple sclerosis; Patient care; Therapeutics