title: Recent advances in component resolved diagnosis in food allergy.
abstract: Due to the high prevalence of food allergic diseases globally there are increasing demands in clinical practice for managing IgE-mediated conditions. During the last decade, component resolved diagnostics has been introduced into the field of clinical allergology, providing information that cannot be obtained from extract-based tests. Component resolved data facilitate more precise diagnosis of allergic diseases and identify sensitizations attributable to cross-reactivity. Furthermore it assists risk assessment in clinical practice as sensitization to some allergenic molecules is related to persistence of clinical symptoms and systemic rather than local reactions. The information may also aid the clinician in prescription of oral immunotherapy (OIT) in patients with severe symptoms, and in giving advice on food allergen avoidance or on the need to perform food challenges. The use of allergen components is rapidly evolving and increases our possibility to treat food allergic patients with a more individual approach. Using molecular allergology, we can already now better diagnose, prognose and grade the food allergy. In summary, daily routine molecular allergy diagnostics offers a number of benefits that give us a higher diagnostic precision and allow for better management of the patient.
authors.affiliation: Department of Maternal and Child Health, Uppsala University, Uppsala, Sweden. Electronic address: magnus.borres@kbh.uu.se.
authors.forename: Magnus P
authors.initials: MP
authors.lastname: Borres
authors.affiliation: Laboratory of Food Quality Design and Development, Graduate School of Agriculture, Kyoto University, Kyoto, Japan.
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Maruyama
authors.affiliation: Department of Allergy, Clinical Research Center for Allergology and Rheumatology, Sagamihara National Hospital, Kanagawa, Japan.
authors.forename: Sakura
authors.initials: S
authors.lastname: Sato
authors.affiliation: Department of Allergy, Clinical Research Center for Allergology and Rheumatology, Sagamihara National Hospital, Kanagawa, Japan.
authors.forename: Motohiro
authors.initials: M
authors.lastname: Ebisawa
mesh_terms: D000485:Allergens / Q000145:classification / Q000276:immunology*; D000818:Animals; D003429:Cross Reactions; D003888:Desensitization, Immunologic; D005502:Food / Q000009:adverse effects / Q000145:classification; D005512:Food Hypersensitivity / Q000175:diagnosis* / Q000276:immunology* / Q000628:therapy; D006801:Humans; D007108:Immune Tolerance; D007073:Immunoglobulin E / Q000276:immunology*
chemical_list: D000485:Allergens; D007073:Immunoglobulin E
keywords: Allergen components; Component resolved diagnosis; Diagnosis; Food allergen; Molecular allergology