title: [A prospective cohort study on the impact of placement timing of LNG-IUS for adenomyosis].
abstract: OBJECTIVE
  To investigate the impact of placement in the procedures of gynecological laparoscopies or routine placement on the effects of levonorgestrel-releasing intrauterine system (LNG-IUS) for symptomatic adenomyosis in a prospective cohort study.
  
  
  METHODS
  From December, 2006 to December, 2014, patients with adenomyosis diagnosed by transvaginal ultrasound in outpatient or inpatient clinics of Peking Union Medical College Hospital received the treatment of LNG-IUS.Before and after placement of LNG-IUS all the parameters were recorded including carrying status of IUS, symptoms and scores of dysmenorrhea, menstruation scores, biochemical indicators, physical parameters, menstruation patterns and adverse effects.Impact of placement timing (in the procedures of laparoscopies vesus routine placement) on the treatment effects, menstruation patterns and adverse effects of LNG-IUS were analyzed.
  
  
  RESULTS
  1 100 patients meet the inclusion criteria, with median age 36 years (20-44 years), median follow-up 35 months (1-108 months), of which 385 cases (35.0%) received LNG-IUS in the procedures of gynecological laparoscopies. Most common indications and pathology outcomes were endometriosis, major of which had deep infiltrating endometriosis. The accumulative carrying ratio of LNG-IUS were 73% and 63% on 60 months for operative patients and non-operative patients respectively (P<0.001), and accumulative take-out ratio were 7.8% and 10.3% (P=0.044). Placement timing of LNG-IUS was the only significant factor related with loss to follow-up (P<0.001) and take-out ratio (P<0.001). Operations and pathological outcome had no significant impact on patients' treatment effects, changes of menstruation patterns, adverse effects in total or in subclass.
  
  
  CONCLUSIONS
  Placement of LNG-IUS in the procedures of gynecological laparoscopies for symptomatic adenomyosis increased carrying ratio and reduce take-out ratio at patients'request, but didn't influence treatment effects or adverse effects.
authors.affiliation: Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Beijing 100730, China.
authors.forename: L
authors.initials: L
authors.lastname: Li
authors.forename: J H
authors.initials: JH
authors.lastname: Leng
authors.forename: J J
authors.initials: JJ
authors.lastname: Zhang
authors.forename: S Z
authors.initials: SZ
authors.lastname: Jia
authors.forename: X Y
authors.initials: XY
authors.lastname: Li
authors.forename: J H
authors.initials: JH
authors.lastname: Shi
authors.forename: Z Z
authors.initials: ZZ
authors.lastname: Liu
authors.forename: S S
authors.initials: SS
authors.lastname: You
authors.forename: X Y
authors.initials: XY
authors.lastname: Chang
authors.forename: Y H
authors.initials: YH
authors.lastname: Lang
mesh_terms: D062788:Adenomyosis; D000328:Adult; D004412:Dysmenorrhea; D004715:Endometriosis; D005260:Female; D006801:Humans; D007436:Intrauterine Devices, Medicated; D016912:Levonorgestrel; D011446:Prospective Studies; D055815:Young Adult
chemical_list: D016912:Levonorgestrel