title: Cabazitaxel-loaded human serum albumin nanoparticles as a therapeutic agent against prostate cancer.
abstract: Cabazitaxel-loaded human serum albumin nanoparticles (Cbz-NPs) were synthesized to overcome vehicle-related toxicity of current clinical formulation of the drug based on Tween-80 (Cbz-Tween). A salting-out method was used for NP synthesis that avoids the use of chlorinated organic solvent and is simpler compared to the methods based on emulsion-solvent evaporation. Cbz-NPs had a narrow particle size distribution, suitable drug loading content (4.9%), and superior blood biocompatibility based on in vitro hemolysis assay. Blood circulation, tumor uptake, and antitumor activity of Cbz-NPs were assessed in prostatic cancer xenograft-bearing nude mice. Cbz-NPs exhibited prolonged blood circulation and greater accumulation of Cbz in tumors along with reduced toxicity compared to Cbz-Tween. Moreover, hematoxylin and eosin histopathological staining of organs revealed consistent results. The levels of blood urea nitrogen and serum creatinine in drug-treated mice showed that Cbz-NPs were less toxic than Cbz-Tween to the kidneys. In conclusion, Cbz-NPs provide a promising therapeutic for prostate cancer.
authors.affiliation: School of Life Sciences, Jilin University, Changchun, People's Republic of China.
authors.forename: Na
authors.initials: N
authors.lastname: Qu
authors.affiliation: School of Life Sciences, Jilin University, Changchun, People's Republic of China; Division of Pharmaceutics, College of Pharmacy, The Ohio State University, Columbus, OH, USA.
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Lee
authors.affiliation: School of Life Sciences, Jilin University, Changchun, People's Republic of China.
authors.forename: Yating
authors.initials: Y
authors.lastname: Sun
authors.affiliation: School of Life Sciences, Jilin University, Changchun, People's Republic of China.
authors.forename: Guangsheng
authors.initials: G
authors.lastname: Cai
authors.affiliation: School of Life Sciences, Jilin University, Changchun, People's Republic of China.
authors.forename: Junyang
authors.initials: J
authors.lastname: Wang
authors.affiliation: School of Life Sciences, Jilin University, Changchun, People's Republic of China.
authors.forename: Mengqiao
authors.initials: M
authors.lastname: Wang
authors.affiliation: School of Life Sciences, Jilin University, Changchun, People's Republic of China.
authors.forename: Jiahui
authors.initials: J
authors.lastname: Lu
authors.affiliation: School of Life Sciences, Jilin University, Changchun, People's Republic of China.
authors.forename: Qingfan
authors.initials: Q
authors.lastname: Meng
authors.affiliation: School of Life Sciences, Jilin University, Changchun, People's Republic of China.
authors.forename: Lirong
authors.initials: L
authors.lastname: Teng
authors.affiliation: School of Life Sciences, Jilin University, Changchun, People's Republic of China.
authors.forename: Di
authors.initials: D
authors.lastname: Wang
authors.affiliation: School of Life Sciences, Jilin University, Changchun, People's Republic of China; State Key Laboratory of Long-acting and Targeting Drug Delivery System, Yantai, People's Republic of China.
authors.forename: Lesheng
authors.initials: L
authors.lastname: Teng
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000737:chemistry / Q000493:pharmacokinetics; D001806:Blood Urea Nitrogen; D003404:Creatinine / Q000097:blood; D004337:Drug Carriers / Q000008:administration & dosage* / Q000737:chemistry / Q000493:pharmacokinetics; D006801:Humans; D008297:Male; D008819:Mice, Nude; D053758:Nanoparticles / Q000008:administration & dosage* / Q000737:chemistry; D010316:Particle Size; D011471:Prostatic Neoplasms / Q000188:drug therapy*; D012709:Serum Albumin / Q000737:chemistry; D043823:Taxoids / Q000008:administration & dosage* / Q000737:chemistry / Q000493:pharmacokinetics; D014018:Tissue Distribution; D023041:Xenograft Model Antitumor Assays
chemical_list: D000970:Antineoplastic Agents; D004337:Drug Carriers; D012709:Serum Albumin; D043823:Taxoids; C552428:cabazitaxel; D003404:Creatinine
keywords: cabazitaxel; drug delivery; human serum albumin; nanoparticle; prostate cancer; toxicity