title: Serum pentraxin 3 is elevated in patients with neurological Wilson's disease.
abstract: BACKGROUND
  Wilson's disease (WD) is an autosomal recessive inherited disorder of copper (Cu) metabolism, resulting in pathological accumulation of Cu in many organs and tissues, predominantly in the liver and brain. Cu deposition may lead to neuroinflammation in the brain of WD patients. Pentraxin 3 (PTX3) may play an important role in innate immunity and in WD. We compared plasma PTX3 concentrations in WD patients and healthy controls, and to determine whether PTX3 concentration was associated with neurological disease severity.
  
  
  METHODS
  This study included 86 WD patients and 28 controls. Plasma PTX3 and C-reactive protein (CRP) concentration levels were measured using specific enzyme-linked immunosorbent assays. Disease severity was determined using the neurological Global Assessment Scale (GAS) for WD.
  
  
  RESULTS
  Plasma PTX3 levels were significantly higher in patients with neurological WD than in controls. PTX3 levels in WD patients were associated with neurological disease severity. However, there was no correlation between CRP and neurological GAS scores.
  
  
  CONCLUSIONS
  PTX3 represents a potential biochemical marker of disease severity in patients with neurological WD.
authors.affiliation: Department of Neurology, Nanfang Hospital, Southern Medical University, Guangzhou, China.
authors.forename: Honghao
authors.initials: H
authors.lastname: Wang
authors.affiliation: Hospital affiliated to Institute of Neurology, Anhui College of TCM, Hefei, China; Hefei Institute of Physical Science, CAS, China.
authors.forename: Nan
authors.initials: N
authors.lastname: Cheng
authors.affiliation: Hospital affiliated to Institute of Neurology, Anhui College of TCM, Hefei, China.
authors.forename: Jianjian
authors.initials: J
authors.lastname: Dong
authors.affiliation: Department of Neurology, Nanfang Hospital, Southern Medical University, Guangzhou, China.
authors.forename: Xun
authors.initials: X
authors.lastname: Wang
authors.affiliation: Hospital affiliated to Institute of Neurology, Anhui College of TCM, Hefei, China.
authors.forename: Yongsheng
authors.initials: Y
authors.lastname: Han
authors.affiliation: Hospital affiliated to Institute of Neurology, Anhui College of TCM, Hefei, China.
authors.forename: Renmin
authors.initials: R
authors.lastname: Yang
authors.affiliation: Hospital affiliated to Institute of Neurology, Anhui College of TCM, Hefei, China. Electronic address: hanyongzhutcm@163.com.
authors.forename: Yongzhu
authors.initials: Y
authors.lastname: Han
mesh_terms: D000328:Adult; D002097:C-Reactive Protein / Q000032:analysis*; D005260:Female; D006527:Hepatolenticular Degeneration / Q000097:blood* / Q000175:diagnosis; D006801:Humans; D008297:Male; D011446:Prospective Studies; D000683:Serum Amyloid P-Component / Q000032:analysis*; D055815:Young Adult; D000099153:Pentraxins
chemical_list: D002097:C-Reactive Protein; D000683:Serum Amyloid P-Component; D000099153:Pentraxins
keywords: Biochemical marker; Neuroinflammation; Pentraxin 3; Wilson's disease