title: Marked elevation of urinary β2-microglobulin in patients with reversible splenial lesions: A small case series.
abstract: The magnetic resonance imaging findings of reversible isolated lesions with transiently reduced diffusion in the splenium of corpus callosum of patients with a wide spectrum of pathological conditions are referred to as reversible splenial lesion syndrome (RESLES). Clinically mild encephalitis/encephalopathy with a reversible splenial lesion (MERS) is probably included within the spectrum of RESLES; however, its exact pathophysiology is not known. Here, we describe three patients with MERS and one patient with RESLES, all of whom showed elevated urinary β2-microglobulin regardless of diagnosis and presence of pathogens. Elevated urinary β2-microglobulin suggested that an excessive immune response might play a role in the pathophysiology of reversible splenial lesions.
authors.affiliation: Department of Pediatrics, Minoh City Hospital, Minoh, Japan. Electronic address: jjazuma2009@gmail.com.
authors.forename: Junji
authors.initials: J
authors.lastname: Azuma
authors.affiliation: Department of Pediatrics, Osaka University Graduate School of Medicine, Suita, Japan.
authors.forename: Shin
authors.initials: S
authors.lastname: Nabatame
authors.affiliation: Department of Pediatrics, Minoh City Hospital, Minoh, Japan.
authors.forename: Toshiya
authors.initials: T
authors.lastname: Katsura
authors.affiliation: Department of Pediatrics, Minoh City Hospital, Minoh, Japan.
authors.forename: Kyoko
authors.initials: K
authors.lastname: Yamamoto
authors.affiliation: Department of Pediatrics, Minoh City Hospital, Minoh, Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kaneno
authors.affiliation: Department of Pediatrics, Minoh City Hospital, Minoh, Japan.
authors.forename: Eri
authors.initials: E
authors.lastname: Kijima
authors.affiliation: Department of Pediatrics, Minoh City Hospital, Minoh, Japan.
authors.forename: Yoshimi
authors.initials: Y
authors.lastname: Mizoguchi
authors.affiliation: Department of Pediatrics, Minoh City Hospital, Minoh, Japan.
authors.forename: Tunesuke
authors.initials: T
authors.lastname: Shimotsuji
authors.affiliation: Department of Pediatrics, Minoh City Hospital, Minoh, Japan.
authors.forename: Takehisa
authors.initials: T
authors.lastname: Yamamoto
authors.affiliation: Department of Pediatrics, Osaka University Graduate School of Medicine, Suita, Japan.
authors.forename: Keiichi
authors.initials: K
authors.lastname: Ozono
mesh_terms: D015415:Biomarkers / Q000652:urine; D001927:Brain Diseases / Q000000981:diagnostic imaging* / Q000188:drug therapy / Q000652:urine*; D002648:Child; D002675:Child, Preschool; D003337:Corpus Callosum / Q000000981:diagnostic imaging*; D038524:Diffusion Magnetic Resonance Imaging; D005260:Female; D006801:Humans; D008297:Male; D001613:beta 2-Microglobulin / Q000652:urine*
chemical_list: D015415:Biomarkers; D001613:beta 2-Microglobulin
keywords: Cytokine; Encephalitis; Mild encephalopathy with a reversible splenial lesion; Reversible splenial lesion syndrome; β2-Microglobulin