title: Metabolic syndrome and cardiovascular disease following hematopoietic cell transplantation: screening and preventive practice recommendations from CIBMTR and EBMT.
abstract: Metabolic syndrome (MetS) is a constellation of cardiovascular risk factors that increases the risk of cardiovascular disease, diabetes mellitus and all cause mortality. Long-term survivors of hematopoietic cell transplantation (HCT) have a substantial risk of developing MetS and cardiovascular disease, with the estimated prevalence of MetS being 31-49% among HCT recipients. Although MetS has not yet been proven to impact cardiovascular risk after HCT, an understanding of the incidence and risk factors for MetS in HCT recipients can provide the foundation to evaluate screening guidelines and develop interventions that may mitigate cardiovascular-related mortality. A working group was established through the Center for International Blood and Marrow Transplant Research and the European Group for Blood and Marrow Transplantation with the goal of reviewing literature and recommend practices appropriate to HCT recipients. Here we deliver consensus recommendations to help clinicians provide screening and preventive care for MetS and cardiovascular disease among HCT recipients. All HCT survivors should be advised of the risks of MetS and encouraged to undergo recommended screening based on their predisposition and ongoing risk factors.
authors.affiliation: Department of Hematology and Medical Oncology, Winship Cancer Institute of Emory University, Atlanta, GA, USA.
authors.forename: Z
authors.initials: Z
authors.lastname: DeFilipp
authors.affiliation: Hospital Universitario Puerta de Hierro Majadahonda, Madrid, Spain.
authors.forename: R F
authors.initials: RF
authors.lastname: Duarte
authors.affiliation: Department of Haematology, Sheffield Teaching Hospitals NHS Foundation Trust and Department of Oncology & Metabolism, University of Sheffield, Sheffield, UK.
authors.forename: J A
authors.initials: JA
authors.lastname: Snowden
authors.affiliation: Department of Hematology and Oncology, Cleveland Clinic, Cleveland, OH, USA.
authors.forename: N S
authors.initials: NS
authors.lastname: Majhail
authors.affiliation: Specialized Cancer Services, Sheffield Teaching Hospital NHS Foundation Trust, Shefflied, UK.
authors.forename: D M
authors.initials: DM
authors.lastname: Greenfield
authors.affiliation: Department of Medicine, Reina Sofia University Hospital, Maimonides Institute for Biomedical Research at Cordoba (IMIBIC), University of Cordoba, CIBER Fisiopatología Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III, Cordoba, Spain.
authors.forename: J L
authors.initials: JL
authors.lastname: Miranda
authors.affiliation: Florence Nightingale Sisli Hospital, Hematopoietic Stem Cell Transplantation Unit, Istanbul, Turkey.
authors.forename: M
authors.initials: M
authors.lastname: Arat
authors.affiliation: Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
authors.forename: K S
authors.initials: KS
authors.lastname: Baker
authors.affiliation: National Marrow Donor Program, University of Minnesota, Minneapolis, MN, USA.
authors.forename: L J
authors.initials: LJ
authors.lastname: Burns
authors.affiliation: Pediatric Stem Cell Transplant, Dana-Farber Cancer Institute, Boston, MA, USA.
authors.forename: C N
authors.initials: CN
authors.lastname: Duncan
authors.affiliation: Leeds Teaching Hospitals NHS Trust, Leeds, UK.
authors.forename: M
authors.initials: M
authors.lastname: Gilleece
authors.affiliation: All Children's Hospital, John Hopkins Medicine, St. Petersburg, FL, USA.
authors.forename: G A
authors.initials: GA
authors.lastname: Hale
authors.affiliation: Department of Medicine, Center for International Blood and Marrow Transplant Research (CIBMTR), Medical College of Wisconsin, Milwaukee, WI, USA.
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authors.initials: M
authors.lastname: Hamadani
authors.affiliation: Department of Hematology and Oncology, Cleveland Clinic, Cleveland, OH, USA.
authors.forename: B K
authors.initials: BK
authors.lastname: Hamilton
authors.affiliation: Division of Hematology, Department of Internal Medicine, Mayo Clinic, Rochester, MN, USA.
authors.forename: W J
authors.initials: WJ
authors.lastname: Hogan
authors.affiliation: Division of Hematology & Oncology, Department of Medicine, University of Florida, Gainesville, FL, USA.
authors.forename: J W
authors.initials: JW
authors.lastname: Hsu
authors.affiliation: Division of Hematopoietic Stem Cell Transplantation, National Cancer Center Hospital, Tokyo, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Inamoto
authors.affiliation: Division of Hematology and Oncology, Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX, USA.
authors.forename: R T
authors.initials: RT
authors.lastname: Kamble
authors.affiliation: Hematology and Bone Marrow Transplantation Unit, San Raffaele Scientific Institute, Milano, Italy.
authors.forename: M T
authors.initials: MT
authors.lastname: Lupo-Stanghellini
authors.affiliation: Division of Hematology/Oncology, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York City, NY, USA.
authors.forename: A K
authors.initials: AK
authors.lastname: Malone
authors.affiliation: Department of Medicine, Roswell Park Cancer Institute, BMT Program, Buffalo, NY, USA.
authors.forename: P
authors.initials: P
authors.lastname: McCarthy
authors.affiliation: University Pierre & Marie Curie, Paris, France.|Hopital Saint-Antoine, AP-HP, Paris, France.|INSERM UMRs 938, Paris, France.
authors.forename: M
authors.initials: M
authors.lastname: Mohty
authors.affiliation: Division of Hematology & Oncology, Department of Medicine, University of Florida, Gainesville, FL, USA.
authors.forename: M
authors.initials: M
authors.lastname: Norkin
authors.affiliation: Department of Medicine, Roswell Park Cancer Institute, BMT Program, Buffalo, NY, USA.
authors.forename: P
authors.initials: P
authors.lastname: Paplham
authors.affiliation: Department Hematology, Oncology and Bone Marrow Transplant, UMass Memorial Medical Center, Worcester, MA, USA.
authors.forename: M
authors.initials: M
authors.lastname: Ramanathan
authors.affiliation: Division of Hematology and Medical Oncology, Department of Internal Medicine, Saint Louis University, St. Louis, MO, USA.
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authors.initials: JM
authors.lastname: Richart
authors.affiliation: Hammersmith Hospital, London, UK.
authors.forename: N
authors.initials: N
authors.lastname: Salooja
authors.affiliation: Maastricht University Medical Center, Maastricht, The Netherlands.
authors.forename: H C
authors.initials: HC
authors.lastname: Schouten
authors.affiliation: Department of Hematology, University Hospital Leuven and KU Leuven, Leuven, Belgium.
authors.forename: H
authors.initials: H
authors.lastname: Schoemans
authors.affiliation: Hospital Samaritano, Sao Paulo, Brazil.|Associação da Medula Ossea - AMEO, Sao Paulo, Brazil.
authors.forename: A
authors.initials: A
authors.lastname: Seber
authors.affiliation: Division of Hematology/Oncology, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York City, NY, USA.
authors.forename: A
authors.initials: A
authors.lastname: Steinberg
authors.affiliation: Department of Internal Medicine, Stony Brook University Medical Center, Stony Brook, NY, USA.
authors.forename: B M
authors.initials: BM
authors.lastname: Wirk
authors.affiliation: Division of Hematology/Oncology, Department of Medicine, University of North Carolina, Chapel Hill, NC, USA.
authors.forename: W A
authors.initials: WA
authors.lastname: Wood
authors.affiliation: Hematology Branch, National Institutes of Health, Bethesda, MD, USA.
authors.forename: M
authors.initials: M
authors.lastname: Battiwalla
authors.affiliation: Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
authors.forename: M E D
authors.initials: ME
authors.lastname: Flowers
authors.affiliation: Division of Hematology/Oncology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
authors.forename: B N
authors.initials: BN
authors.lastname: Savani
authors.affiliation: Department of Medicine, Center for International Blood and Marrow Transplant Research (CIBMTR), Medical College of Wisconsin, Milwaukee, WI, USA.
authors.forename: B E
authors.initials: BE
authors.lastname: Shaw
mesh_terms: D064591:Allografts; D002318:Cardiovascular Diseases / Q000209:etiology / Q000517:prevention & control; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects*; D006801:Humans; D024821:Metabolic Syndrome / Q000209:etiology / Q000517:prevention & control; D017410:Practice Guidelines as Topic