title: Metatheases: artificial metalloproteins for olefin metathesis.
abstract: The incorporation of organometallic catalyst precursors in proteins results in so-called artificial metalloenzymes. The protein structure will control activity, selectivity and stability of the organometallic site in aqueous medium and allow non-natural reactions in biological settings. Grubbs-Hoveyda type ruthenium catalysts with an N-heterocyclic carbene (NHC) as ancillary ligand, known to be active in olefin metathesis, have recently been incorporated in various proteins. An overview of these artificial metalloproteins and their potential application in olefin metathesis is given.
authors.affiliation: Institute of Inorganic Chemistry, RWTH Aachen University, Landoltweg 1, 52056 Aachen, Germany. jun.okuda@ac.rwth-aachen.de.
authors.forename: D F
authors.initials: DF
authors.lastname: Sauer
authors.forename: S
authors.initials: S
authors.lastname: Gotzen
authors.forename: J
authors.initials: J
authors.lastname: Okuda
mesh_terms: D000475:Alkenes / Q000737:chemistry*; D040761:Biomimetic Materials / Q000737:chemistry*; D002384:Catalysis; D008667:Metalloproteins / Q000737:chemistry*
chemical_list: D000475:Alkenes; D008667:Metalloproteins