title: A Fibrous Localized Drug Delivery Platform with NIR-Triggered and Optically Monitored Drug Release.
abstract: Implantable localized drug delivery systems (LDDSs) with intelligent functionalities have emerged as a powerful chemotherapeutic platform in curing cancer. Developing LDDSs with rationally controlled drug release and real-time monitoring functionalities holds promise for personalized therapeutic protocols but suffers daunting challenges. To overcome such challenges, a series of porous Yb(3+)/Er(3+) codoped CaTiO3 (CTO:Yb,Er) nanofibers, with specifically designed surface functionalization, were synthesized for doxorubicin (DOX) delivery. The content of DOX released could be optically monitored by increase in the intensity ratio of green to red emission (I550/I660) of upconversion photoluminescent nanofibers under 980 nm near-infrared (NIR) excitation owing to the fluorescence resonance energy transfer (FRET) effect between DOX molecules and the nanofibers. More importantly, the 808 nm NIR irradiation enabled markedly accelerated DOX release, confirming representative NIR-triggered drug release properties. In consequence, such CTO:Yb,Er nanofibers presented significantly enhanced in vitro anticancer efficacy under NIR irradiation. This study has thus inspired another promising fibrous LDDS platform with NIR-triggered and optics-monitored DOX releasing for personalized tumor chemotherapy.
authors.affiliation: State Key Laboratory of Silicon Materials, School of Materials Science and Engineering, Zhejiang University , Hangzhou 310027, P.R. China.
authors.forename: Heng
authors.initials: H
authors.lastname: Liu
authors.affiliation: State Key Laboratory of Silicon Materials, School of Materials Science and Engineering, Zhejiang University , Hangzhou 310027, P.R. China.
authors.forename: Yike
authors.initials: Y
authors.lastname: Fu
authors.affiliation: State Key Laboratory of Silicon Materials, School of Materials Science and Engineering, Zhejiang University , Hangzhou 310027, P.R. China.
authors.forename: Yangyang
authors.initials: Y
authors.lastname: Li
authors.affiliation: State Key Laboratory of Silicon Materials, School of Materials Science and Engineering, Zhejiang University , Hangzhou 310027, P.R. China.
authors.forename: Zhaohui
authors.initials: Z
authors.lastname: Ren
authors.affiliation: State Key Laboratory of Silicon Materials, School of Materials Science and Engineering, Zhejiang University , Hangzhou 310027, P.R. China.
authors.forename: Xiang
authors.initials: X
authors.lastname: Li
authors.affiliation: State Key Laboratory of Silicon Materials, School of Materials Science and Engineering, Zhejiang University , Hangzhou 310027, P.R. China.
authors.forename: Gaorong
authors.initials: G
authors.lastname: Han
authors.affiliation: State Key Laboratory of Silicon Materials, School of Materials Science and Engineering, Zhejiang University , Hangzhou 310027, P.R. China.|Department of Chemistry & Biochemistry, Stephenson Life Sciences Research Center, University of Oklahoma , 101 Stephenson Parkway, Norman, Oklahoma 73019-5300, United States.
authors.forename: Chuanbin
authors.initials: C
authors.lastname: Mao
mesh_terms: D000903:Antibiotics, Antineoplastic / Q000737:chemistry / Q000494:pharmacology*; D017610:Calcium Compounds / Q000737:chemistry; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D003692:Delayed-Action Preparations / Q000138:chemical synthesis / Q000378:metabolism / Q000528:radiation effects*; D004317:Doxorubicin / Q000737:chemistry / Q000494:pharmacology*; D004337:Drug Carriers; D004339:Drug Compounding / Q000379:methods; D065546:Drug Liberation; D031541:Fluorescence Resonance Energy Transfer; D022781:Hepatocytes / Q000187:drug effects* / Q000473:pathology; D006801:Humans; D007259:Infrared Rays; D007700:Kinetics; D057139:Nanofibers / Q000737:chemistry* / Q000648:ultrastructure; D010087:Oxides / Q000737:chemistry; D014025:Titanium / Q000737:chemistry
chemical_list: D000903:Antibiotics, Antineoplastic; D017610:Calcium Compounds; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D010087:Oxides; C059910:perovskite; D004317:Doxorubicin; D014025:Titanium