title: Pulpal response following photo-biomodulation with a 904-nm diode laser: a double-blind clinical study.
abstract: The aim of this study was to evaluate pulpal responses in healthy human teeth to photo-biomodulation therapy (PBMT) with 904-nm GaAs diode laser. The study followed a double-blind split mouth design, with a randomly selected maxillary first premolar acting as a sham-irradiated control tooth, and the contralateral tooth receiving active laser treatment. Two coded but otherwise identical laser probes (Irradia™, SpectraMedics Ltd., NC, USA) were used to deliver the sham (placebo) and laser radiation, with both the operator and patient unaware of each probe's identity. The selection of teeth for sham or laser irradiation was randomised for each treatment. Pulpal responses were assessed using electric pulp testing (EPT), 2 min prior to exposure, and immediately after laser irradiation (60 s, 30 mW average power, 25 Hz pulse frequency, 3.6 J/cm2). Treatment effects were analysed using the Wilcoxon-signed rank test. A total of 30 participants provided written informed consent. Majority of the participants (66.7 %) demonstrated an analgesic effect following PBMT (elevated EPT scores); however, nine participants (30 %) reported the lower EPT scores than the control. Both the treatment effects (stimulation and analgesia) were significant compared to the placebo. In most individuals, PBMT of healthy teeth with a 904-nm GaAs diode laser can induce analgesia, as witnessed by elevated EPT scores. A converse effect can occur in a minority of subjects.
authors.affiliation: School of Dentistry and Oral Health, Griffith University, Gold Coast, 4214, Queensland, Australia.
authors.forename: Ryan
authors.initials: R
authors.lastname: Liang
authors.affiliation: School of Dentistry and Oral Health, Griffith University, Gold Coast, 4214, Queensland, Australia. drroygeorge@gmail.com.|Discipline Lead Endodontics, Griffith University Gold Coast Campus, Gold Coast, 4214, Queensland, Australia. drroygeorge@gmail.com.
authors.forename: Roy
authors.initials: R
authors.lastname: George
authors.affiliation: School of Dentistry, The University of Queensland, Brisbane, Australia.
authors.forename: Laurence J
authors.initials: LJ
authors.lastname: Walsh
mesh_terms: D000328:Adult; D001152:Arsenicals; D001641:Bicuspid; D003782:Dental Pulp / Q000528:radiation effects*; D004311:Double-Blind Method; D005260:Female; D005708:Gallium; D006801:Humans; D054023:Lasers, Semiconductor / Q000627:therapeutic use*; D028022:Low-Level Light Therapy / Q000379:methods*; D008297:Male; D010146:Pain / Q000532:radiotherapy; D010147:Pain Measurement
chemical_list: D001152:Arsenicals; C043055:gallium arsenide; D005708:Gallium
keywords: Analgesia; Diode laser; Endodontics; Pain; Pulp testing