title: Effect of the rs10767664 Variant of the Brain-Derived Neurotrophic Factor Gene on Weight Change and Cardiovascular Risk Factors in Morbidly Obese Patients after Biliopancreatic Diversion Surgery.
abstract: The effect of the rs10767664 variant of the brain-derived neurotrophic factor gene on weight loss after bariatric surgery has not been evaluated. We decided to investigate the role of the rs10767664 variant on outcomes after biliopancreatic diversion surgery.
  
  
  
  A sample of 90 patients with morbid obesity without diabetes mellitus was operated. Biochemical and anthropometric evaluation were realized at basal visit and at each visit during 3 years (at 1, 2 and 3 years).
  
  
  
  Initial percentage excess weight loss, body mass index, weight, waist circumference, fat mass, blood pressure, low-density lipoprotein cholesterol, total cholesterol, triglyceride levels, insulin and homeostasis model assessment for insulin resistance (HOMA-IR) improved. No differences in these changes were detected between the two genotypes (wild-type group AA vs. mutant group AT plus TT) in a dominant model. The improvement of insulin levels was lower in T-allele carriers than non-T-allele carriers (-2.8 ± 0.7 vs. -7.1 ± 0.9 UI/dl; p = 0.02). The decrease of fasting glucose (-13.4 ± 7.4 vs. -24.2 ± 5.2 mg/dl; p = 0.01) and HOMA-IR (-1.1 ± 0.3 vs. -0.5 ± 0.4 units; p = 0.02) were lower in T-allele carriers than non-T-allele carriers.
  
  
  
  Our data showed an association between the rs10767664 variant and metabolic response after weight loss. Non-T-allele carriers have a better improvement in glucose, insulin and HOMA-IR levels than T-allele carriers.
authors.affiliation: Center of Investigation of Endocrinology and Nutrition, Medicine School and Department of Endocrinology and Nutrition, Hospital Clinico Universitario, University of Valladolid, Valladolid, Spain.
authors.forename: Daniel Antonio
authors.initials: DA
authors.lastname: de Luis
authors.forename: Olatz
authors.initials: O
authors.lastname: Izaola
authors.forename: David
authors.initials: D
authors.lastname: Primo
authors.forename: David
authors.initials: D
authors.lastname: Pacheco
mesh_terms: D000328:Adult; D015904:Biliopancreatic Diversion; D001786:Blood Glucose / Q000378:metabolism; D019208:Brain-Derived Neurotrophic Factor / Q000235:genetics*; D002318:Cardiovascular Diseases / Q000235:genetics; D005260:Female; D006801:Humans; D007333:Insulin Resistance / Q000235:genetics; D008297:Male; D008875:Middle Aged; D054647:Nutrigenomics; D009767:Obesity, Morbid / Q000235:genetics* / Q000503:physiopathology / Q000601:surgery*; D020641:Polymorphism, Single Nucleotide; D011446:Prospective Studies; D012307:Risk Factors; D015431:Weight Loss / Q000235:genetics*
chemical_list: D001786:Blood Glucose; D019208:Brain-Derived Neurotrophic Factor; C579455:BDNF protein, human