title: Efficacy and Safety of Renal Sympathetic Denervation on Dogs with Pressure Overload-Induced Heart Failure.
abstract: BACKGROUND
  In dogs with heart failure (HF) induced by overload pressure, the role of renal sympathetic denervation (RSD) on heart failure and in the renal artery is unclear. Therefore, we investigated the efficacy and safety of RSD in dogs with pressure overload-induced heart failure.
  
  
  METHODS
  Twenty mongrel dogs were divided into a sham-operated group, an HF group and an HF + RSD group. In the sham-operated group, the abdominal aorta was located but was not constricted, in the HF group, the abdominal aorta was constricted without RSD, and the HF+RSD group underwent RSD with constriction of the abdominal aorta after 10 weeks. Blood sampling assays, echocardiography, intravascular ultrasound (IVUS) measurement and histopathological examination were performed.
  
  
  RESULTS
  Renal sympathetic denervation caused a significant reduction in the levels of noradrenaline (166.62±6.84 vs. 183.48±13.66 pg/ml, P<0.05), plasma renin activity (1.93±0.12 vs. 2.10±0.13 ng/mlh, P<0.05) and B-type natriuretic peptide (71.14±3.86 vs. 83.15±5.73 pg/ml, P<0.05) at eight weeks after RSD in the HF+RSD group. Compared with the HF group at eight weeks, the left ventricular internal dimension at end-diastole and end-systole were lower and the left ventricular ejection fraction was higher (all P<0.05) at eight weeks after RSD in the HF+RSD group. Intravenous ultrasound images showed no changes in the renal artery lumen, and intimal hyperplasia and vascular lumen stenosis were not observed after RSD.
  
  
  CONCLUSIONS
  Renal sympathetic denervation could improve cardiac function in dogs with HF induced by pressure overload; RSD had no adverse influence on the renal artery.
authors.affiliation: Department of Cardiology, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou, China. Electronic address: cwdeyx8@163.com.
authors.forename: Pingan
authors.initials: P
authors.lastname: Chen
authors.affiliation: Department of Human Anatomy, School of Basic Science, Guangzhou Medical University, Guangzhou, China.
authors.forename: Shuilong
authors.initials: S
authors.lastname: Leng
authors.affiliation: Department of Cardiology, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou, China.
authors.forename: Yishan
authors.initials: Y
authors.lastname: Luo
authors.affiliation: Department of Cardiology, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou, China.
authors.forename: Shaonan
authors.initials: S
authors.lastname: Li
authors.affiliation: Invasive Technology Department, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou, China.
authors.forename: Zicheng
authors.initials: Z
authors.lastname: Huang
authors.affiliation: Department of Pathology, Zhujiang Hospital, Southern Medical University, Guangzhou, China.
authors.forename: Zhenxi
authors.initials: Z
authors.lastname: Liu
authors.affiliation: Department of Cardiology, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou, China.
authors.forename: Zhen
authors.initials: Z
authors.lastname: Liu
authors.affiliation: Ultrasonic Department, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Wang
authors.affiliation: Department of Cardiology, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou, China.
authors.forename: Xiaoming
authors.initials: X
authors.lastname: Lei
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D004285:Dogs; D006333:Heart Failure / Q000097:blood / Q000503:physiopathology / Q000601:surgery; D006352:Heart Ventricles / Q000503:physiopathology; D007668:Kidney / Q000098:blood supply / Q000294:innervation / Q000503:physiopathology; D009638:Norepinephrine / Q000097:blood; D012077:Renal Artery / Q000294:innervation / Q000503:physiopathology; D013318:Stroke Volume; D013562:Sympathectomy
chemical_list: D009638:Norepinephrine
keywords: Heart failure; Pressure overload; Renal sympathetic denervation