title: A survey exploring the knowledge and perceptions of senior medical students in Nepal toward generic medicines.
abstract: BACKGROUND
  The accurate knowledge of generic medicine issues among future prescribers will enhance the prescribing of cost-effective medicines. This study aimed to explore the knowledge and perception of senior medical students about the generic medicines.
  
  
  METHODS
  A cross-sectional study was conducted among 237 senior medical students (final year students and interns) using a validated self-administered questionnaire. The collected data were analyzed using Statistical Package for the Social Sciences version 20 for windows and comparison of difference was done using linear by linear association. A p value of less than 0.05 was taken as statistically significant.
  
  
  RESULTS
  The average age (standard deviation) of the respondents was 23.54 (1.39) years. Almost 5% of respondents correctly answered the question regarding the regulatory limits for bioequivalence. Almost two-thirds of respondents correctly agreed that generic medicine is bioequivalent to a brand-name medicine, and 79.3% and 72.5% of respondents correctly agreed that the medicine should be present in the same dosage form and same dose, respectively, as the brand-name medicines. However, almost half of the respondents had impression that brand-name medicines are required to meet higher safety standard than generic medicines. Almost 90% of respondents felt that advertisement by the drug companies would influence the use of brand-name medicine and they need more information about generic medicine.
  
  
  CONCLUSIONS
  This study highlights the negative perception and knowledge deficit among the respondents. The students' responses to almost all the statements were almost similar to the respondents' academic year (final year students and interns), gender and nationality.
authors.affiliation: Department of Pharmacology, Manipal College of Medical Sciences (MCOMS), Pokhara, Nepal.
authors.forename: Sudesh
authors.initials: S
authors.lastname: Gyawali
authors.affiliation: Discipline of Social and Administrative Pharmacy, School of Pharmaceutical Sciences, Universiti Sains Malaysia, Pulau Pinang, Malaysi.
authors.forename: Mohamed Azmi
authors.initials: MA
authors.lastname: Hassali
authors.affiliation: Department of Pharmacology, Manipal College of Medical Sciences (MCOMS), Pokhara, Nepal.
authors.forename: Archana
authors.initials: A
authors.lastname: Saha
keywords: Generic medicines; generic prescribing; generic substitution; medical students