title: Sarcopenia and Physical Function in Middle-Aged and Older Stroke Survivors.
abstract: To determine the prevalence of sarcopenia in stroke survivors using different methodologies, and compare a subset of the stroke group to age-, sex-, and body mass index (BMI)-matched nonstroke control counterparts.
  
  
  
  Cohort study.
  
  
  
  A Veterans Affairs medical center and a university hospital.
  
  
  
  Mild to moderately disabled participants >6 months after onset of stroke aged 40 to 84 years (N=190, 61% men, 57% African American; mean BMI ± SEM, 29±1kg/m2).
  
  
  
  Not applicable.
  
  
  
  Dual-energy x-ray absorptiometry scans to assess appendicular lean mass (ALM). Rates of sarcopenia were determined using 4 established methods: (1) ALM/height2(ALM/ht2); (2) European Working Group on Sarcopenia in Older Persons; (3) International Working Group on Sarcopenia; and (4) ALM/BMI.
  
  
  
  Sarcopenia prevalence in our stroke cohort ranged between 14% and 18%. The stroke survivor subset (n=38) matched one-for-one with control counterparts for race, sex, age ±4 years and BMI ±2.5kg/m2had higher prevalence rates compared with their nonstroke counterparts (13.2% vs 5.3%, P<.0001). ALM/ht2was related to 6-minute walking speed (r=.28, P<.01) and peak oxygen consumption (L/min: r=.58, P<.0001) for the stroke group.
  
  
  
  Stroke survivors show an elevated prevalence of sarcopenia when considering age, sex, and race compared with nonstroke individuals.
authors.affiliation: Department of Medicine, Division of Gerontology and Geriatric Medicine, University of Maryland School of Medicine, Baltimore, MD; Baltimore Veterans Administration Maryland Health Care System Geriatric Research, Education and Clinical Center, Baltimore, MD; Maryland Exercise and Robotics Center of Excellence, Baltimore, MD. Electronic address: aryan@grecc.umaryland.edu.
authors.forename: Alice S
authors.initials: AS
authors.lastname: Ryan
authors.affiliation: Department of Neurology, University of Maryland School of Medicine, Baltimore, MD; Baltimore Veterans Administration Maryland Health Care System Geriatric Research, Education and Clinical Center, Baltimore, MD; Maryland Exercise and Robotics Center of Excellence, Baltimore, MD.
authors.forename: Frederick M
authors.initials: FM
authors.lastname: Ivey
authors.affiliation: Department of Medicine, Division of Gerontology and Geriatric Medicine, University of Maryland School of Medicine, Baltimore, MD; Baltimore Veterans Administration Maryland Health Care System Geriatric Research, Education and Clinical Center, Baltimore, MD; Maryland Exercise and Robotics Center of Excellence, Baltimore, MD.
authors.forename: Monica C
authors.initials: MC
authors.lastname: Serra
authors.affiliation: Department of Medicine, Division of Gerontology and Geriatric Medicine, University of Maryland School of Medicine, Baltimore, MD; Baltimore Veterans Administration Maryland Health Care System Geriatric Research, Education and Clinical Center, Baltimore, MD; Maryland Exercise and Robotics Center of Excellence, Baltimore, MD.
authors.forename: Joseph
authors.initials: J
authors.lastname: Hartstein
authors.affiliation: Department of Neurology, University of Maryland School of Medicine, Baltimore, MD; Baltimore Veterans Administration Maryland Health Care System Geriatric Research, Education and Clinical Center, Baltimore, MD; Maryland Exercise and Robotics Center of Excellence, Baltimore, MD.
authors.forename: Charlene E
authors.initials: CE
authors.lastname: Hafer-Macko
mesh_terms: D015502:Absorptiometry, Photon; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D015992:Body Mass Index; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D053580:Muscle Strength / Q000502:physiology; D018482:Muscle, Skeletal / Q000503:physiopathology; D010101:Oxygen Consumption; D055948:Sarcopenia / Q000453:epidemiology*; D012737:Sex Factors; D020521:Stroke / Q000453:epidemiology* / Q000503:physiopathology*; D014481:United States; D014493:United States Department of Veterans Affairs
keywords: Exercise; Muscles; Rehabilitation; Sarcopenia; Stroke