title: Intestinal tuft cells: epithelial sentinels linking luminal cues to the immune system.
abstract: Epithelial tuft cells (also known as "brush" cells in the airway) were first identified morphologically, almost six decades ago in the trachea and gastro-intestinal tract, but their function remained mysterious until three almost simultaneous reports recently revealed their essential role in the initiation of immune type 2 responses. This is a new and exciting example of cooperation between the epithelial and haematopoietic compartments for the management of enteric parasite infections. Here we review tuft cell functions and markers, and anchors epithelial tuft cells within the current paradigm of type 2 immune responses.
authors.affiliation: CNRS, UMR-5203, Institut de Génomique Fonctionnelle, Montpellier, France.|INSERM, U1191, Montpellier, France.|Université de Montpellier, Montpellier, France.
authors.forename: F
authors.initials: F
authors.lastname: Gerbe
authors.affiliation: CNRS, UMR-5203, Institut de Génomique Fonctionnelle, Montpellier, France.|INSERM, U1191, Montpellier, France.|Université de Montpellier, Montpellier, France.
authors.forename: P
authors.initials: P
authors.lastname: Jay
mesh_terms: D000818:Animals; D015415:Biomarkers; D002454:Cell Differentiation / Q000235:genetics; D049109:Cell Proliferation; D004847:Epithelial Cells / Q000276:immunology / Q000378:metabolism; D006373:Helminthiasis / Q000276:immunology / Q000378:metabolism / Q000469:parasitology; D006376:Helminths / Q000276:immunology; D006790:Host-Parasite Interactions / Q000235:genetics / Q000276:immunology; D006801:Humans; D007107:Immune System / Q000166:cytology* / Q000502:physiology*; D007109:Immunity; D007413:Intestinal Mucosa / Q000166:cytology* / Q000502:physiology*; D008871:Microvilli / Q000378:metabolism; D050810:Octamer Transcription Factors / Q000235:genetics / Q000378:metabolism; D051192:Receptors, Pattern Recognition / Q000378:metabolism; D015398:Signal Transduction; D050053:TRPM Cation Channels / Q000378:metabolism
chemical_list: D015415:Biomarkers; D050810:Octamer Transcription Factors; D051192:Receptors, Pattern Recognition; D050053:TRPM Cation Channels