title: Physicochemical properties and antioxidant activity of α-tocopherol loaded nanoliposome's containing DHA and EPA.
abstract: The aim of this study was to prepare α-tocopherol loaded nanoliposomes as carriers of DHA and EPA and to investigate their physicochemical properties, such as peroxide value (PV), volatile compounds (VOCs), particle size, size distribution, zeta potential and morphology of the liposomes. The particle size of liposomes was in the range of 82.4-107.2nm. The highest extent of lipid oxidation was observed at 40°C for 90days, with the lowest PV and propanal levels for a nanoliposome formulation in comparison with the control sample. The zeta potential of the nanoliposomes was decreased during storage. No significant change in the PV and zeta potential of the liposome formulations with α-tocopherol was observed at 4°C after 90days (0.14meq/kg and -43.5mV, respectively). This study demonstrated that incorporation of α-tocopherol into liposomes contributes a significant antioxidant effect on DHA and EPA.
authors.affiliation: Department of Food Technology, Faculty of Agriculture, Tarbiat Modares University, Tehran, Iran.
authors.forename: Mohammad Ali
authors.initials: MA
authors.lastname: Sahari
authors.affiliation: Department of Pharmaceutics, Faculty of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors.forename: Hamid Reza
authors.initials: HR
authors.lastname: Moghimi
authors.affiliation: Department of Food Science and Technology, National Nutrition Science and Food Science Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Electronic address: z_hadian@sbmu.ac.ir.
authors.forename: Zahra
authors.initials: Z
authors.lastname: Hadian
authors.affiliation: Department of Food Technology, Faculty of Agriculture, Tarbiat Modares University, Tehran, Iran.
authors.forename: Mohsen
authors.initials: M
authors.lastname: Barzegar
authors.affiliation: Department of Food Science and Technology, National Nutrition Science and Food Science Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors.forename: Abdorreza
authors.initials: A
authors.lastname: Mohammadi
mesh_terms: D000975:Antioxidants / Q000737:chemistry*; D002626:Chemistry, Pharmaceutical; D004281:Docosahexaenoic Acids / Q000737:chemistry*; D015118:Eicosapentaenoic Acid / Q000737:chemistry*; D008081:Liposomes / Q000737:chemistry; D053758:Nanoparticles / Q000737:chemistry; D010084:Oxidation-Reduction; D010316:Particle Size; D024502:alpha-Tocopherol / Q000737:chemistry*
chemical_list: D000975:Antioxidants; D008081:Liposomes; D004281:Docosahexaenoic Acids; D015118:Eicosapentaenoic Acid; D024502:alpha-Tocopherol
keywords: Boron trifluoride- methanol (PubChem CID: 11062313); DHA; Dipalmitoyl phosphatidylcholine (PubChem CID: 160339); Docosahexaenoic acid (PubChem CID: 445580); EPA; Eicosapentaenoic acid (PubChem CID: 446284); Heptanal (PubChem CID: 8130); Hexanal (PubChem CID: 6184); Methyl paraben (PubChem CID: 7456); N-dodecane (PubChem CID: 8182); Nanoliposome; Octanal (PubChem CID: 454); Pentadecanoic acid (PubChem CID: 13849); Peroxide value; Propanal (PubChem CID: 527); Propyl paraben (PubChem CID: 7175); Stability; Volatile compounds; d-alpha-tocopherol (PubChem CID: 14985); α-Tocopherol