title: Mechanism of action of herbs and their active constituents used in hair loss treatment.
abstract: This article discusses the mechanisms via topically applied products containing herbs and their active constituents affect the hair growth process. It was reported that the mechanisms involving (1) insulin-like growth factor-I (IGF-I), (2) vascular endothelial growth factor (VEGF), (3) epidermal growth factor (EGF), (4) fibroblast growth factor 2 (FGF-2), (5) endothelial nitric oxide synthase (eNOS), (6) Wnt/β-catenin signalling pathway, (7) prostaglandin E (PGE), (8) prostaglandin F (PGF) stimulate hair growth, whereas the mechanisms engaging (1) 5α-reductase and dihydrotestosterone (DHT), (2) transforming growth factor beta (TGF-β), (3) fibroblast growth factor 5 (FGF-5), (4) prostaglandin D2(PGD2) inhibit hair growth. The knowledge summarized in the paper may be an inspiration to create new preparations for the treatment of hair loss.
authors.affiliation: Faculty of Cosmetology, The Academy of Cosmetics and Health Care, Podwale 13 street, 00-252 Warsaw, Poland. Electronic address: anna.herman@onet.pl.
authors.forename: Anna
authors.initials: A
authors.lastname: Herman
authors.affiliation: Laboratory of Molecular Biology, The Kielanowski Institute of Animal Physiology and Nutrition, Polish Academy of Sciences, Instytucka 3 street, 05-110 Jabłonna, near Warsaw, Poland.
authors.forename: Andrzej P
authors.initials: AP
authors.lastname: Herman
mesh_terms: D000287:Administration, Topical; D000505:Alopecia / Q000188:drug therapy*; D000818:Animals; D004815:Epidermal Growth Factor / Q000378:metabolism; D005346:Fibroblast Growth Factors / Q000378:metabolism; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000378:metabolism; D051379:Mice; D052250:Nitric Oxide Synthase Type III / Q000378:metabolism; D028321:Plant Preparations / Q000627:therapeutic use*; D011453:Prostaglandins / Q000378:metabolism; D016212:Transforming Growth Factor beta / Q000378:metabolism; D042461:Vascular Endothelial Growth Factor A / Q000378:metabolism; D060449:Wnt Signaling Pathway
chemical_list: D028321:Plant Preparations; D011453:Prostaglandins; D016212:Transforming Growth Factor beta; D042461:Vascular Endothelial Growth Factor A; D005346:Fibroblast Growth Factors; D004815:Epidermal Growth Factor; D007334:Insulin-Like Growth Factor I; D052250:Nitric Oxide Synthase Type III
keywords: Hair growth; Hair loss; Herbs; Herbs active constituents; Mechanism of action