title: [Tidal breathing pulmonary function after treatment in neonates with respiratory distress syndrome].
abstract: OBJECTIVE
  To investigate the pulmonary function after treatment in neonates with respiratory distress syndrome (RDS) at varying disease severity levels and different gestational ages.
  
  
  METHODS
  A total of 107 neonates with RDS were divided into <34 weeks group (65 neonates), late preterm group (21 neonates), full-term group (21 neonates). Another 121 non-RDS children were enrolled as the control group. According to the severity of RDS, the RDS neonates were divided into mild RDS group (grades 1 and 2; 76 neonates), and severe RDS (grades 3 and 4; 21 neonates). The tidal breathing pulmonary function was measured at a corrected gestational age of 44weeks.
  
  
  RESULTS
  The pulmonary function parameters showed no significant differences across the groups of RDS neonates of different gestational ages; the tidal volume per kilogram of body weight (VT/kg) showed no significant difference between the RDS and non-RDS groups, while the RDS group had significantly higher ratio of time to peak tidal expiratory flow to total expiratory time (tPTEF/tE) and ratio of volume to peak tidal expiratory flow to total expiratory volume (vPTEF/vE) than the non-RDS group of the same gestational age (P<0.05). At a corrected gestational age of 44 weeks, the two groups of neonates with varying severity levels of RDS had significantly lower tPTEF/tE and vPTEF/vE than the control group (P<0.05), and tPTEF/tE and vPTEF/vE tended to decrease with the increasing severity level of RDS.
  
  
  CONCLUSIONS
  Neonates with RDS have significantly decreased pulmonary function than those without RDS. At a corrected gestational age of 44 weeks, the tidal breathing pulmonary function in neonates with RDS is not associated with gestational age, but is associated with the severity of RDS.
authors.affiliation: Department of Neonatology, Third Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China. jiling1225@126.com.
authors.forename: Ling
authors.initials: L
authors.lastname: Ji
authors.forename: Li-Ya
authors.initials: LY
authors.lastname: Ma
authors.forename: Yun
authors.initials: Y
authors.lastname: Yang
authors.forename: Na-Na
authors.initials: NN
authors.lastname: Huang
mesh_terms: D005260:Female; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D008168:Lung / Q000503:physiopathology*; D008297:Male; D012127:Respiratory Distress Syndrome, Newborn / Q000503:physiopathology*