title: Skin manifestations of POEMS and AESOP syndrome in the same patient revealing plasma cell dyscrasia.
abstract: POEMS (polyneuropathy, organomegaly, endocrinopathy, monoclonal protein and skin signs) and AESOP (adenopathy and extensive skin patch overlying a plasmacytoma) syndromes are rare paraneoplastic conditions due to an underlying plasma cell dyscrasia. We report a 70-year-old patient with the rare coexistence of POEMS and AESOP syndromes and in whom skin signs, that differ both clinically and histologically, were the clues to the diagnosis of a plasma cell disorder. Vascular endothelial growth factor-A overexpression seems to be the common pathogenetic link of the different clinicopathological presentations of the skin lesions.
authors.affiliation: AOU, S. Giovanni di Dio Hospital, Mario Aresu Department of Medical Science, Section of Dermatology, University of Cagliari, Cagliari, Italy.
authors.forename: Franco
authors.initials: F
authors.lastname: Rongioletti
authors.affiliation: Experimental Immunology Laboratory, IDI-IRCCS, Rome, Italy.
authors.forename: Maria C
authors.initials: MC
authors.lastname: Failla
authors.affiliation: AOU, S. Giovanni di Dio Hospital, Mario Aresu Department of Medical Science, Section of Dermatology, University of Cagliari, Cagliari, Italy.
authors.forename: Laura
authors.initials: L
authors.lastname: Atzori
authors.affiliation: AOU, S. Giovanni di Dio Hospital, Mario Aresu Department of Medical Science, Section of Dermatology, University of Cagliari, Cagliari, Italy.
authors.forename: Caterina
authors.initials: C
authors.lastname: Ferreli
mesh_terms: D000368:Aged; D006801:Humans; D008297:Male; D016878:POEMS Syndrome / Q000209:etiology* / Q000378:metabolism / Q000473:pathology; D010257:Paraneoplastic Syndromes / Q000209:etiology* / Q000378:metabolism / Q000473:pathology; D010265:Paraproteinemias / Q000150:complications*; D010954:Plasmacytoma / Q000473:pathology; D012871:Skin Diseases / Q000209:etiology* / Q000378:metabolism / Q000473:pathology; D042461:Vascular Endothelial Growth Factor A / Q000096:biosynthesis
chemical_list: C467484:VEGFA protein, human; D042461:Vascular Endothelial Growth Factor A
keywords: AESOP; POEMS; VEGF-A; glomeruloid hemangioma; plasma cell disorder