title: The role of EGFR-TKI for leptomeningeal metastases from non-small cell lung cancer.
abstract: Leptomeningeal metastasis (LM) is a terminal event in the development of non-small cell lung cancer (NSCLC). It has a poor prognosis with median survival of 1.9 months if untreated. The improvement of OS in NSCLC patients relatively increases incidence of LM. While current therapeutic options for LM are limited. Epidermal growth factor receptor-tyrosine kinase inhibitors are a class of small molecules and show dramatic response in epidermal growth factor receptor mutated patients. It also has a distinct therapeutic potential against brain metastases. Although there are some studies on EGFR-TKIs and brain metastases, the role of EGFR-TKIs on LM are not fully clarified. In this review, we will summarize current evidences concerning the use and discuss the role of EGFR-TKIs on LM.
authors.affiliation: School of Medicine, Jiaxing University, Jiaxing, 314000 Zhejiang People's Republic of China.|Department of Oncology, The First Affiliated Hospital of Jiaxing University, No. 1882, Zhonghuan South Road, Jiaxing, 314000 Zhejiang People's Republic of China.
authors.forename: Xu
authors.initials: X
authors.lastname: Yufen
authors.affiliation: School of Medicine, Jiaxing University, Jiaxing, 314000 Zhejiang People's Republic of China.|Department of Oncology, The First Affiliated Hospital of Jiaxing University, No. 1882, Zhonghuan South Road, Jiaxing, 314000 Zhejiang People's Republic of China.
authors.forename: Song
authors.initials: S
authors.lastname: Binbin
authors.affiliation: School of Medicine, Jiaxing University, Jiaxing, 314000 Zhejiang People's Republic of China.|Department of Oncology, The First Affiliated Hospital of Jiaxing University, No. 1882, Zhonghuan South Road, Jiaxing, 314000 Zhejiang People's Republic of China.
authors.forename: Chen
authors.initials: C
authors.lastname: Wenyu
authors.affiliation: School of Medicine, Jiaxing University, Jiaxing, 314000 Zhejiang People's Republic of China.|Department of Oncology, The First Affiliated Hospital of Jiaxing University, No. 1882, Zhonghuan South Road, Jiaxing, 314000 Zhejiang People's Republic of China.
authors.forename: Liu
authors.initials: L
authors.lastname: Jialiang
authors.affiliation: School of Medicine, Jiaxing University, Jiaxing, 314000 Zhejiang People's Republic of China.|Department of Oncology, The First Affiliated Hospital of Jiaxing University, No. 1882, Zhonghuan South Road, Jiaxing, 314000 Zhejiang People's Republic of China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Xinmei
keywords: EGFR-TKIs; Leptomeningeal metastasis; Non-small cell lung cancer