title: Sensory aspects in myasthenia gravis: A translational approach.
abstract: Myasthenia gravis is a paradigmatic muscle disorder characterized by abnormal fatigue and muscle weakness that worsens with activities and improves with rest. Clinical and research studies done on nicotinic acetylcholine receptors have advanced our knowledge of the muscle involvement in myasthenia. Current views still state that sensory deficits are not "features of myasthenia gravis". This article discusses the gap that exists on sensory neural transmission in myasthenia that has remained after >300years of research in this neurological disorder. We outline the neurobiological characteristics of sensory and motor synapses, reinterpret the nanocholinergic commonalities that exist in both sensory and motor pathways, discuss the clinical findings on altered sensory pathways in myasthenia, and propose a novel way to score anomalies resulting from multineuronal inability associated sensory troubles due to eugenic nanocholinergic instability and autoimmunity. This medicine-based evidence could serve as a template to further identify novel targets for studying new medications that may offer a better therapeutic benefit in both sensory and motor dysfunction for patients. Importantly, this review may help to re-orient current practices in myasthenia.
authors.affiliation: Smell & Taste Center, Department of Otorhinolaryngology, University of Pennsylvania, PA, United States; Mediciencias Research Group, Universidad Nacional/Unicolciencias, Bogota, Colombia. Electronic address: feleones@gmail.com.
authors.forename: Fidias E
authors.initials: FE
authors.lastname: Leon-Sarmiento
authors.affiliation: Mediciencias Research Group, Universidad Nacional/Unicolciencias, Bogota, Colombia; Faculty of Medicine, Universidad de La Sabana, Chía, Colombia.
authors.forename: Juan S
authors.initials: JS
authors.lastname: Leon-Ariza
authors.affiliation: Department of Environmental Health, Harvard T.H. Chan School of Public Health, Harvard University, Boston, MA, United States; Unidad de Investigación Biomédica en Cáncer, Instituto Nacional de Cancerología - Universidad Nacional Autónoma de México-UNAM, México City, Mexico.
authors.forename: Diddier
authors.initials: D
authors.lastname: Prada
authors.affiliation: Mediciencias Research Group, Universidad Nacional/Unicolciencias, Bogota, Colombia; Department of Neurosurgery, The Johns Hopkins University, Baltimore, MD, United States; Faculty of Health Sciences, Universidad de Santander, UDES, Bucaramanga, Colombia.
authors.forename: Daniel S
authors.initials: DS
authors.lastname: Leon-Ariza
authors.affiliation: Charity Association for Person Centered Medicine - Moral Entity, Bologna, Italy.
authors.forename: Carlos V
authors.initials: CV
authors.lastname: Rizzo-Sierra
mesh_terms: D000818:Animals; D049670:History, 17th Century; D049671:History, 18th Century; D049672:History, 19th Century; D049673:History, 20th Century; D006801:Humans; D009069:Movement Disorders / Q000209:etiology*; D009157:Myasthenia Gravis / Q000266:history / Q000473:pathology / Q000503:physiopathology* / Q000628:therapy; D012678:Sensation Disorders / Q000209:etiology*; D013569:Synapses / Q000473:pathology; D014175:Translating
keywords: Acetylcholine; Muscle weakness; Myasthenia gravis; Pain; Synapses