title: p-Terphenyl Derivatives from the Endolichenic Fungus Floricola striata.
abstract: Ten new p-terphenyl derivatives, floricolins A-J (1-10), together with six known compounds (11-16), were isolated from the extract of the endolichenic fungus Floricola striata. Chemical structures of these compounds were elucidated using spectroscopic data (HRESIMS and NMR). Among them, 9 and 10 were enantiomeric mixtures, and their configurations were established by single-crystal X-ray diffraction analysis using Cu Kα radiation. Evaluation of the isolated compounds against Candida albicans revealed that the most active compound, 3 (MIC 8 μg/mL), exerted fungicidal action by destruction of the cell membrane.
authors.affiliation: Department of Natural Products Chemistry, Key Lab of Chemical Biology of Ministry of Education, School of Pharmaceutical Sciences, Shandong University , No. 44 West Wenhua Road, Jinan 250012, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Li
authors.affiliation: College of Life Sciences, Shandong Normal University , No. 88 East Wenhua Road, Jinan 250014, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Gao
authors.affiliation: Department of Natural Products Chemistry, Key Lab of Chemical Biology of Ministry of Education, School of Pharmaceutical Sciences, Shandong University , No. 44 West Wenhua Road, Jinan 250012, China.
authors.forename: Ming
authors.initials: M
authors.lastname: Zhang
authors.affiliation: Department of Natural Products Chemistry, Key Lab of Chemical Biology of Ministry of Education, School of Pharmaceutical Sciences, Shandong University , No. 44 West Wenhua Road, Jinan 250012, China.
authors.forename: Yue-Lan
authors.initials: YL
authors.lastname: Li
authors.affiliation: Department of Natural Products Chemistry, Key Lab of Chemical Biology of Ministry of Education, School of Pharmaceutical Sciences, Shandong University , No. 44 West Wenhua Road, Jinan 250012, China.
authors.forename: Lin
authors.initials: L
authors.lastname: Li
authors.affiliation: Department of Natural Products Chemistry, Key Lab of Chemical Biology of Ministry of Education, School of Pharmaceutical Sciences, Shandong University , No. 44 West Wenhua Road, Jinan 250012, China.
authors.forename: Xiao-Bin
authors.initials: XB
authors.lastname: Li
authors.affiliation: Department of Natural Products Chemistry, Key Lab of Chemical Biology of Ministry of Education, School of Pharmaceutical Sciences, Shandong University , No. 44 West Wenhua Road, Jinan 250012, China.
authors.forename: Wen-Qiang
authors.initials: WQ
authors.lastname: Chang
authors.affiliation: College of Life Sciences, Shandong Normal University , No. 88 East Wenhua Road, Jinan 250014, China.
authors.forename: Zun-Tian
authors.initials: ZT
authors.lastname: Zhao
authors.affiliation: Department of Natural Products Chemistry, Key Lab of Chemical Biology of Ministry of Education, School of Pharmaceutical Sciences, Shandong University , No. 44 West Wenhua Road, Jinan 250012, China.
authors.forename: Hong-Xiang
authors.initials: HX
authors.lastname: Lou
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry; D001203:Ascomycota / Q000737:chemistry*; D002176:Candida albicans / Q000187:drug effects; D018360:Crystallography, X-Ray; D004926:Escherichia coli / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D013211:Staphylococcus aureus / Q000187:drug effects; D013730:Terphenyl Compounds / Q000737:chemistry / Q000302:isolation & purification*
chemical_list: D000900:Anti-Bacterial Agents; D013730:Terphenyl Compounds