title: Cycling Rho for tissue contraction.
abstract: Cell contractility, driven by the RhoA GTPase, is a fundamental determinant of tissue morphogenesis. In this issue, Mason et al. (2016. J. Cell Biol http://dx.doi.org/10.1083/jcb.201603077) reveal that cyclic inactivation of RhoA, mediated by its antagonist, C-GAP, is essential for effective contractility to occur.
authors.affiliation: Division of Cell Biology and Molecular Medicine, Institute for Molecular Bioscience, The University of Queensland, St. Lucia, Brisbane, Queensland, Australia 4072.
authors.forename: Jessica L
authors.initials: JL
authors.lastname: Teo
authors.affiliation: Division of Cell Biology and Molecular Medicine, Institute for Molecular Bioscience, The University of Queensland, St. Lucia, Brisbane, Queensland, Australia 4072 a.yap@imb.uq.edu.au.
authors.forename: Alpha S
authors.initials: AS
authors.lastname: Yap
mesh_terms: D000818:Animals; D016764:Cell Polarity; D006801:Humans; D008954:Models, Biological; D009928:Organ Specificity; D064067:Rho Guanine Nucleotide Exchange Factors; D020741:rho GTP-Binding Proteins / Q000378:metabolism*
chemical_list: D064067:Rho Guanine Nucleotide Exchange Factors; D020741:rho GTP-Binding Proteins