title: Body Mass Index and Mortality: A 10-Year Prospective Study in China.
abstract: Although several studies have evaluated the role of body weight as a risk factor for mortality, most studies have been conducted in Western populations and the findings remain controversial. We performed a prospective study to examine the association between body mass index (BMI) and all-cause mortality in Yinzhou District, Ningbo, China. At baseline, 384,533 subjects were recruited through the Yinzhou Health Information System between 2004 and 2009. The final analysis was restricted to 372,793 participants (178,333 men and 194,460 women) aged 18 years and older. Cox proportional hazards models were used to estimate hazard ratios(HRs) and 95% confidence intervals(CIs). We found an increased risk of all-cause mortality among individuals with BMI levels <22.5-24.9, although several groups were not statistically significant-adjusted HRs for persons with BMIs of <15.0, 15.0-17.4, 17.5-19.9, and 20.0-22.4 were 1.61(95% CI: 1.17-2.23), 1.07(0.94-1.20), 1.04(0.98-1.10), 1.06(1.02-1.11), respectively. In the upper BMI range, subjects with BMIs of 25.0-34.9 had a reduced risk of all-cause mortality. Sensitivity analyses excluding smokers, those with prevalent chronic disease or those with less than four years of follow-up did not materially alter these results. Our findings provide evidence for an inverse association of BMI and mortality in this population.
authors.affiliation: Department of Epidemiology and Biostatistics, School of Public Health, Zhejiang University, Hangzhou 310058, China.|Research Center for Air Pollution and Health, Zhejiang University, Hangzhou 310058, China.
authors.forename: Jian-Bing
authors.initials: JB
authors.lastname: Wang
authors.affiliation: Department of Epidemiology and Biostatistics, School of Public Health, Zhejiang University, Hangzhou 310058, China.
authors.forename: Meng-Jia
authors.initials: MJ
authors.lastname: Gu
authors.affiliation: Yinzhou District Center for Disease Control and Prevention, Ningbo, 315100, China.
authors.forename: Peng
authors.initials: P
authors.lastname: Shen
authors.affiliation: Department of Epidemiology and Biostatistics, School of Public Health, Zhejiang University, Hangzhou 310058, China.
authors.forename: Qiu-Chi
authors.initials: QC
authors.lastname: Huang
authors.affiliation: Department of Epidemiology and Biostatistics, School of Public Health, Zhejiang University, Hangzhou 310058, China.
authors.forename: Chen-Zheng
authors.initials: CZ
authors.lastname: Bao
authors.affiliation: Department of Epidemiology and Biostatistics, School of Public Health, Zhejiang University, Hangzhou 310058, China.
authors.forename: Zhen-Hua
authors.initials: ZH
authors.lastname: Ye
authors.affiliation: Zhejiang Cancer Hospital, 310022, China.
authors.forename: You-Qing
authors.initials: YQ
authors.lastname: Wang
authors.affiliation: Department of Epidemiology and Biostatistics, School of Public Health, Zhejiang University, Hangzhou 310058, China.
authors.forename: Mamat
authors.initials: M
authors.lastname: Mayila
authors.affiliation: Department of Epidemiology and Biostatistics, School of Public Health, Zhejiang University, Hangzhou 310058, China.
authors.forename: Ding
authors.initials: D
authors.lastname: Ye
authors.affiliation: Michigan State University, 48824, USA.
authors.forename: Shi-Tong
authors.initials: ST
authors.lastname: Gu
authors.affiliation: Yinzhou District Center for Disease Control and Prevention, Ningbo, 315100, China.
authors.forename: Hong-Bo
authors.initials: HB
authors.lastname: Lin
authors.affiliation: Department of Epidemiology and Biostatistics, School of Public Health, Zhejiang University, Hangzhou 310058, China.|Research Center for Air Pollution and Health, Zhejiang University, Hangzhou 310058, China.
authors.forename: Kun
authors.initials: K
authors.lastname: Chen
mesh_terms: D000328:Adult; D000368:Aged; D015992:Body Mass Index; D002681:China / Q000453:epidemiology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009026:Mortality; D011446:Prospective Studies; D012307:Risk Factors