title: The Evolving Context of Driver Mutations: ROS1 Rearrangement in Metastatic Non-Small Cell Lung Cancer.
abstract: A previously healthy, 30-year-old Filipino woman presented to an emergency department with complaints of shortness of breath and mild cough. She denied constitutional symptoms, such as night sweats, fevers, loss of appetite, or weight loss. Additional investigation revealed bilateral pleural and pericardial effusions with no obvious lung lesions or masses. The pericardial fluid was drained and preliminary cytology revealed atypical carcinoma cells. Her past medical history included an embryonic pregnancy and a benign breast cyst that was biopsied in the Philippines. She had immigrated to Canada two years earlier, was working full-time, and was living with her sister. She was planning on returning to the Philippines to wed and had a strong support system in Canada. She had never smoked cigarettes or consumed alcohol and had no family history of cancer. The patient was exposed to secondhand smoke as a child. .
authors.affiliation: CancerCare Manitoba.
authors.forename: Ximena
authors.initials: X
authors.lastname: DeCaire
authors.affiliation: CancerCare Manitoba, Winnipeg, Canada.
authors.forename: Erin
authors.initials: E
authors.lastname: Streu
mesh_terms: D000328:Adult; D000970:Antineoplastic Agents; D044466:Asian People / Q000235:genetics*; D002170:Canada; D002289:Carcinoma, Non-Small-Cell Lung / Q000188:drug therapy* / Q000235:genetics*; D002945:Cisplatin; D003841:Deoxycytidine / Q000031:analogs & derivatives / Q000627:therapeutic use; D006801:Humans; D009154:Mutation / Q000235:genetics; D009362:Neoplasm Metastasis / Q000188:drug therapy* / Q000235:genetics*; D000068437:Pemetrexed / Q000627:therapeutic use; D010679:Philippines; D017382:Reactive Oxygen Species; D016896:Treatment Outcome; D000093542:Gemcitabine
chemical_list: D000970:Antineoplastic Agents; D017382:Reactive Oxygen Species; D000068437:Pemetrexed; D003841:Deoxycytidine; D002945:Cisplatin; D000093542:Gemcitabine
keywords: ambulatory care/office nursing; biotherapy/targeted therapies; clinical practice; lung cancer