title: Investigation of the association between matrix metalloproteinase-9 genetic polymorphisms and development of pre-eclampsia in Chinese pregnant women.
abstract: We carried out a case-control study to evaluate the role of MMP-9 -1562 C/T (rs3918242) genetic polymorphism in the risk of pre-eclampsia in Chinese pregnant women. Between March 2013 and January 2015, 107 pregnant women with pre-eclampsia were recruited from the Second Affiliated Hospital of Zhengzhou University. Genotyping of MMP-9 was carried out using polymerase chain reaction-restriction fragment length polymorphism assay. Unconditional logistic regression analyses revealed that women with the CT genotype (OR = 1.81, 95%CI = 1.04-3.11) exhibited significantly higher risk of pre-eclampsia than those with the wild-type CC genotype. Moreover, individuals carrying the T allele were at higher risk of pre-eclampsia than those carrying the C allele; the adjusted OR (95%CI) was 1.62 (1.06-2.47). In conclusion, our study demonstrated that the MMP-9 -1562 C/T polymorphism plays an important role in the development of pre-eclampsia in Chinese women. Further studies with large sample sizes are greatly needed to confirm our findings.
authors.affiliation: Department of Gynecology and Obstetrics, Second Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
authors.forename: C
authors.initials: C
authors.lastname: Sun
authors.affiliation: Department of Gynecology and Obstetrics, Second Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
authors.forename: Q
authors.initials: Q
authors.lastname: Zhang
authors.affiliation: Department of Gynecology and Obstetrics, Second Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
authors.forename: B
authors.initials: B
authors.lastname: Hu
authors.affiliation: Department of Gynecology and Obstetrics, Second Affiliated Hospital of Zhengzhou University, Zhengzhou, China zhangkke22@163.com.
authors.forename: K
authors.initials: K
authors.lastname: Zhang
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D020780:Matrix Metalloproteinase 9 / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D011225:Pre-Eclampsia / Q000235:genetics*; D011247:Pregnancy; D012306:Risk; D017422:Sequence Analysis, DNA; D055815:Young Adult
chemical_list: C579270:MMP9 protein, human; D020780:Matrix Metalloproteinase 9