title: Osseointegration behavior of novel Ti-Nb-Zr-Ta-Si alloy for dental implants: an in vivo study.
abstract: This study aimed to evaluate the effects of Ti-Nb-Zr-Ta-Si alloy implants on mineral apposition rate and new BIC contact in rabbits. Twelve Ti-Nb-Zr-Ta-Si alloy implants were fabricated and placed into the right femur sites in six rabbits, and commercially pure titanium implants were used as controls in the left femur. Tetracycline and alizarin red were administered 3 weeks and 1 week before euthanization, respectively. At 4 weeks and 8 weeks after implantation, animals were euthanized, respectively. Surface characterization and implant-bone contact surface analysis were performed by using a scanning electron microscope and an energy dispersive X-ray detector. Mineral apposition rate was evaluated using a confocal laser scanning microscope. Toluidine blue staining was performed on undecalcified sections for histology and histomorphology evaluation. Scanning electron microscope and histomorphology observation revealed a direct contact between implants and bone of all groups. After a healing period of 4 weeks, Ti-Nb-Zr-Ta-Si alloy implants showed significantly higher mineral apposition rate compared to commercially pure titanium implants (P < 0.05), whereas there was no significant difference between Ti-Nb-Zr-Ta-Si alloy implants and commercially pure titanium implants (P > 0.05) at 8 weeks. No significant difference of bone-to-implant contact was observed between Ti-Nb-Zr-Ta-Si alloy implants and commercially pure titanium implants implants after a healing period of 4 weeks and 8 weeks. This study showed that Ti-Nb-Zr-Ta-Si alloy implants could establish a close direct contact comparedto commercially pure titanium implants implants, improved mineral matrix apposition rate, and may someday be an alternative as a material for dental implants.
authors.affiliation: Jilin Provincial Key Laboratory of Tooth Development and Bone Remodeling, Department of Dental Implantology, School and Hospital of Stomatology, Jilin University, Changchun, China.
authors.forename: Xiaona
authors.initials: X
authors.lastname: Wang
authors.affiliation: Jilin Provincial Key Laboratory of Tooth Development and Bone Remodeling, Department of Dental Implantology, School and Hospital of Stomatology, Jilin University, Changchun, China.
authors.forename: Xing
authors.initials: X
authors.lastname: Meng
authors.affiliation: Jilin Provincial Key Laboratory of Tooth Development and Bone Remodeling, Department of Dental Implantology, School and Hospital of Stomatology, Jilin University, Changchun, China.
authors.forename: Shunli
authors.initials: S
authors.lastname: Chu
authors.affiliation: Jilin Provincial Key Laboratory of Tooth Development and Bone Remodeling, Department of Dental Implantology, School and Hospital of Stomatology, Jilin University, Changchun, China.
authors.forename: Xingchen
authors.initials: X
authors.lastname: Xiang
authors.affiliation: Jilin Provincial Key Laboratory of Tooth Development and Bone Remodeling, Department of Dental Implantology, School and Hospital of Stomatology, Jilin University, Changchun, China.
authors.forename: Zhenzhen
authors.initials: Z
authors.lastname: Liu
authors.affiliation: Jilin Provincial Key Laboratory of Tooth Development and Bone Remodeling, Department of Dental Implantology, School and Hospital of Stomatology, Jilin University, Changchun, China. zhaojh_1986@126.com.
authors.forename: Jinghui
authors.initials: J
authors.lastname: Zhao
authors.affiliation: Jilin Provincial Key Laboratory of Tooth Development and Bone Remodeling, Department of Dental Implantology, School and Hospital of Stomatology, Jilin University, Changchun, China. 15143170757@163.com.
authors.forename: Yanmin
authors.initials: Y
authors.lastname: Zhou
mesh_terms: D000497:Alloys; D000818:Animals; D000880:Anthraquinones / Q000008:administration & dosage; D015921:Dental Implants; D005269:Femur; D020007:Implants, Experimental; D018613:Microscopy, Confocal; D008855:Microscopy, Electron, Scanning; D009556:Niobium / Q000737:chemistry*; D016348:Osseointegration / Q000187:drug effects*; D011817:Rabbits; D012825:Silicon / Q000737:chemistry*; D013499:Surface Properties; D013635:Tantalum / Q000737:chemistry*; D013752:Tetracycline / Q000008:administration & dosage; D014025:Titanium / Q000737:chemistry*; D014965:X-Rays; D015040:Zirconium / Q000737:chemistry*
chemical_list: D000497:Alloys; D000880:Anthraquinones; D015921:Dental Implants; D009556:Niobium; C010078:alizarin; D013635:Tantalum; D015040:Zirconium; D014025:Titanium; D013752:Tetracycline; D012825:Silicon