title: Chondroitin sulfate/dermatan sulfate sulfatases from mammals and bacteria.
abstract: Sulfatases that specifically catalyze the hydrolysis of the sulfate groups on chondroitin sulfate (CS)/dermatan sulfate (DS) poly- and oligosaccharides belong to the formylglycine-dependent family of sulfatases and have been widely found in various mammalian and bacterial organisms. However, only a few types of CS/DS sulfatase have been identified so far. Recently, several novel CS/DS sulfatases have been cloned and characterized. Advanced studies have provided significant insight into the biological function and mechanism of action of CS/DS sulfatases. Moreover, further studies will provide powerful tools for structural and functional studies of CS/DS as well as related applications. This article reviews the recent progress in CS/DS sulfatase research and is expected to initiate further research in this field.
authors.affiliation: National Glycoengineering Research Center, Shandong Provincial Key Laboratory of Carbohydrate Chemistry and Glycobiology, and Shenzhen Research Institute, Shandong University, Jinan, 250100, Peoples, Republic of China.
authors.forename: Shumin
authors.initials: S
authors.lastname: Wang
authors.affiliation: Proteoglycan Signaling and Therapeutics Research Group, Faculty of Advanced Life Science, Hokkaido University Graduate School of Life Science, Sapporo, 001-0021, Japan. k-sugar@sci.hokudai.ac.jp.|Department of Pathobiochemistry, Faculty of Pharmacy, Nagoya, Aichi, 468-8503, Japan. k-sugar@sci.hokudai.ac.jp.
authors.forename: Kazuyuki
authors.initials: K
authors.lastname: Sugahara
authors.affiliation: National Glycoengineering Research Center, Shandong Provincial Key Laboratory of Carbohydrate Chemistry and Glycobiology, and Shenzhen Research Institute, Shandong University, Jinan, 250100, Peoples, Republic of China. fuchuanli@sdu.edu.cn.
authors.forename: Fuchuan
authors.initials: F
authors.lastname: Li
mesh_terms: D000818:Animals; D001419:Bacteria / Q000201:enzymology*; D001426:Bacterial Proteins / Q000737:chemistry* / Q000378:metabolism; D002809:Chondroitin Sulfates / Q000737:chemistry* / Q000378:metabolism; D003871:Dermatan Sulfate / Q000737:chemistry* / Q000378:metabolism; D006801:Humans; D013329:Structure-Activity Relationship; D013429:Sulfatases / Q000737:chemistry* / Q000378:metabolism
chemical_list: D001426:Bacterial Proteins; D003871:Dermatan Sulfate; D002809:Chondroitin Sulfates; D013429:Sulfatases
keywords: Chondroitin sulfate; Dermatan sulfate; Glycosaminoglycan; Sulfatase