title: Novel Approaches to Neonatal Resuscitation and the Impact on Birth Asphyxia.
abstract: Historically, recommendations for neonatal resuscitation were largely based on dogma, but there is renewed interest in performing resuscitation studies at birth. The emphasis for resuscitation following birth asphyxia is administering effective ventilation, as adequate lung aeration leads not only to an increase in oxygenation but also increased pulmonary blood flow and heart rate. To aerate the lung, an initial sustained inflation can increase heart rate, oxygenation, and blood pressure recovery much faster when compared with standard ventilation. Hyperoxia should be avoided, and extra oxygen given to restore cardiac function and spontaneous breathing should be titrated based on oxygen saturations.
authors.affiliation: Division of Neonatology, Department of Pediatrics, Leiden University Medical Centre, J6-S, PO Box 9600, Leiden 2300 RC, The Netherlands. Electronic address: a.b.te_pas@lumc.nl.
authors.forename: Arjan B
authors.initials: AB
authors.lastname: Te Pas
authors.affiliation: Institute of Neuroscience and Physiology, The Sahlgrenska Academy, University of Gothenburg, Box 432, Göteborg 405 30, Sweden.
authors.forename: Kristina
authors.initials: K
authors.lastname: Sobotka
authors.affiliation: The Ritchie Centre, MIMR-PHI Institute of Medical Research, Monash Institute of Medical Research, Monash University, 27-31 Wright Street, Clayton, Melbourne, Victoria 3168, Australia.
authors.forename: Stuart B
authors.initials: SB
authors.lastname: Hooper
mesh_terms: D058109:Airway Management / Q000379:methods; D001238:Asphyxia Neonatorum / Q000628:therapy*; D001794:Blood Pressure; D005260:Female; D006339:Heart Rate; D006439:Hemodynamics; D006801:Humans; D007231:Infant, Newborn; D010102:Oxygen Inhalation Therapy; D011247:Pregnancy; D011652:Pulmonary Circulation; D012121:Respiration, Artificial / Q000379:methods*; D012151:Resuscitation / Q000379:methods*; D013396:Suction
keywords: Asphyxia; Cardiac compressions; Cord clamping; Oxygen; Resuscitation; Sustained inflation