title: Evaluation of peri-implant crevicular fluid prostaglandin E2levels in augmented extraction sockets by different biomaterials.
abstract: OBJECTIVE
  This study compares peri-implant crevicular fluid (PICF) prostaglandin E2(PGE2) levels, clinical parameters and implant stability quotient (ISQ) values around implants placed in augmented extraction sockets.
  
  
  METHODS
  The sockets (24 in total) were randomly augmented using either EMD or Bio-Oss Collagen. Implant placements were performed after three months of healing. ISQ readings were evaluated at three points: at the time of surgery, at the first month and at the third month. PICF was collected for PGE2evaluation after the first and the third months of implant surgery.
  
  
  RESULTS
  After the first month, a higher level of PICF PGE2was observed in the EMD group than in the Bio-Oss Collagen group, and this increase was of statistical significance; however, at the third month there was no statistically significant difference in PICF PGE2levels between the two groups. For implants placed in EMD sites, ISQ values were statistically higher at the third month than at the first month, while no significant differences in ISQ value were detected between the first and third months in Bio-Oss Collagen sites.
  
  
  CONCLUSIONS
  The results of this research suggest that both EMD and Bio-Oss Collagen are effective treatment modalities for stimulating the formation of new bone at extraction sites prior to implant surgery.
authors.affiliation: a Department of Periodontology , Yüzüncü Y?l University, Faculty of Dentistry , Van , Turkey.
authors.forename: Eylem Ayhan
authors.initials: EA
authors.lastname: Alkan
authors.affiliation: b Department of Periodontology , Gazi University, Faculty of Dentistry , Emek , Ankara , Turkey.
authors.forename: Gülay
authors.initials: G
authors.lastname: Tüter
authors.affiliation: c Department of Periodontology , Gazi University, Faculty of Dentistry , Ankara , Turkey.
authors.forename: Ateş
authors.initials: A
authors.lastname: Parlar
authors.affiliation: d Department of Immunology , Gazi University, Faculty of Medicine , Beşevler , Ankara , Turkey.
authors.forename: Ayşegül
authors.initials: A
authors.lastname: Yücel
authors.affiliation: b Department of Periodontology , Gazi University, Faculty of Dentistry , Emek , Ankara , Turkey.
authors.forename: Bülent
authors.initials: B
authors.lastname: Kurtiş
mesh_terms: D000328:Adult; D000540:Alveolar Ridge Augmentation / Q000379:methods*; D001672:Biocompatible Materials / Q000627:therapeutic use*; D015519:Bone Density / Q000502:physiology; D018786:Bone Substitutes / Q000627:therapeutic use*; D003094:Collagen / Q000627:therapeutic use; D003746:Dental Enamel Proteins / Q000627:therapeutic use; D003758:Dental Implantation, Endosseous / Q000379:methods; D015921:Dental Implants; D003774:Dental Plaque Index; D015232:Dinoprostone / Q000032:analysis*; D005260:Female; D005500:Follow-Up Studies; D005883:Gingival Crevicular Fluid / Q000737:chemistry*; D006801:Humans; D008297:Male; D008875:Middle Aged; D008903:Minerals / Q000627:therapeutic use; D010012:Osteogenesis / Q000502:physiology; D010512:Periodontal Index; D020390:Tooth Socket / Q000601:surgery*; D014945:Wound Healing / Q000502:physiology
chemical_list: C077540:Bio-Oss; D001672:Biocompatible Materials; D018786:Bone Substitutes; D003746:Dental Enamel Proteins; D015921:Dental Implants; D008903:Minerals; C109069:enamel matrix proteins; D003094:Collagen; D015232:Dinoprostone
keywords: Extraction sockets; augmentation; peri-implant crevicular fluid; prostoglandin E2