title: Recent "omics" advances in Helicobacter pylori.
abstract: The development of high-throughput whole genome sequencing (WGS) technologies is changing the face of microbiology, facilitating the comparison of large numbers of genomes from different lineages of a same organism. Our aim was to review the main advances on Helicobacter pylori "omics" and to understand how this is improving our knowledge of the biology, diversity and pathogenesis of H. pylori. Since the first H. pylori isolate was sequenced in 1997, 510 genomes have been deposited in the NCBI archive, providing a basis for improved understanding of the epidemiology and evolution of this important pathogen. This review focuses on works published between April 2015 and March 2016. Helicobacter "omics" is already making an impact and is a growing research field. Ultimately these advances will be translated into a routine clinical laboratory setting in order to improve public health.
authors.affiliation: College of Medicine, Institute of Life Science, Swansea University, Swansea, UK.
authors.forename: Elvire
authors.initials: E
authors.lastname: Berthenet
authors.affiliation: Departments of Biology and Biochemistry, University of Bath, Claverton Down, Bath, UK.
authors.forename: Sam
authors.initials: S
authors.lastname: Sheppard
authors.affiliation: Host-Pathogen Interactions Unit, Research Institute for Medicines (iMed-ULisboa), Instituto de Medicina Molecular, Faculdade de Farmácia da Universidade de Lisboa, Lisboa, Portugal.
authors.forename: Filipa F
authors.initials: FF
authors.lastname: Vale
mesh_terms: D019143:Evolution, Molecular; D005798:Genes, Bacterial; D016680:Genome, Bacterial; D016480:Helicobacter pylori / Q000235:genetics* / Q000472:pathogenicity / Q000502:physiology; D006801:Humans; D020071:Interspersed Repetitive Sequences; D017422:Sequence Analysis, DNA; D059467:Transcriptome
keywords: genetic admixture; genomics and transcriptomics; mobile elements; pathogenicity islands; target new therapy