title: Immunohistochemical localization of fatty acid transporters and MCT1 in the sebaceous glands of mouse skin.
abstract: The sebaceous glands secrete sebum to protect the epidermis and hairs by the oily products. The glands express several transporters and binding proteins for the production of fatty acids and uptake of their sources. The present immunohistochemical study examined the expression and localization of CD36, MCT1, FATP4, and E-FABP in the sebaceous glands, including the meibomian and preputial glands of mice. CD36 and MCT1 in sebaceous glands were largely co-localized along the plasma membrane of secretory cells, while they were separately expressed in the glandular portion of meibomian and preputial glands. Immunoreactivities for FATP4 and E-FABP appeared diffusely in the cytoplasm of secretory cells. Genetic deletion of CD36 did not affect the immunolocalization of the three other molecules. The sebaceous glands were judged to be useful for analyzing the functions and relation of fatty acid transporters and binding proteins.
authors.affiliation: Laboratory of Histology and Cytology, Department of Anatomy, Hokkaido University Graduate School of Medicine.
authors.forename: Miao
authors.initials: M
authors.lastname: Zheng
authors.forename: Shinhye
authors.initials: S
authors.lastname: Lee
authors.forename: Satoshi
authors.initials: S
authors.lastname: Tsuzuki
authors.forename: Kazuo
authors.initials: K
authors.lastname: Inoue
authors.forename: Daisaku
authors.initials: D
authors.lastname: Masuda
authors.forename: Shizuya
authors.initials: S
authors.lastname: Yamashita
authors.forename: Toshihiko
authors.initials: T
authors.lastname: Iwanaga
mesh_terms: D000818:Animals; D015415:Biomarkers; D050612:Fatty Acid Transport Proteins / Q000378:metabolism*; D007150:Immunohistochemistry; D008297:Male; D051379:Mice; D027501:Monocarboxylic Acid Transporters / Q000378:metabolism*; D021381:Protein Transport; D012627:Sebaceous Glands / Q000378:metabolism* / Q000648:ultrastructure; D027981:Symporters / Q000378:metabolism*; D000099233:Monocarboxylate Transport Protein 1
chemical_list: D015415:Biomarkers; D050612:Fatty Acid Transport Proteins; D027501:Monocarboxylic Acid Transporters; D027981:Symporters; D000099233:Monocarboxylate Transport Protein 1