title: Facile synthesis of nonsymmetrical heteroaryl-substituted triarylmethanes via the FeCl3·6H2O-catalyzed two-step Friedel-Crafts-type reaction.
abstract: The FeCl3·6H2O-catalyzed three-component aza-Friedel-Crafts reaction of aromatic/heteroaromatic compounds, aromatic aldehydes and tert-butyl carbamate was reported. The subsequent Friedel-Crafts-type alkylation of the resulting tert-butyl diarylmethyl carbamate with heteroaromatic compounds under "open-flask" at room temperature was also performed. The two-step reaction was especially useful for the synthesis of functionalized nonsymmetrical heteroaryl-substituted triarylmethanes in good yields under an air atmosphere at room temperature.
authors.affiliation: Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Burapha University, Chonburi 20131, Thailand. jaray@buu.ac.th.
authors.forename: S
authors.initials: S
authors.lastname: Ruengsangtongkul
authors.forename: P
authors.initials: P
authors.lastname: Taprasert
authors.forename: U
authors.initials: U
authors.lastname: Sirion
authors.forename: J
authors.initials: J
authors.lastname: Jaratjaroonphong