title: Swine (Sus scrofa) as a Model of Postinfarction Mitral Regurgitation and Techniques to Accommodate Its Effects during Surgical Repair.
abstract: Mitral regurgitation (MR) is a common heart-valve lesion after myocardial infarction in humans. Because it is considered a risk factor for accelerated heart failure and death, various surgical approaches and catheter-based devices to correct it are in development. Lack of a reproducible animal model of MR after myocardial infarction and reliable techniques to perform open-heart surgery in these diseased models led to the use of healthy animals to test new devices. Thus, most devices that are deemed safe in healthy animals have shown poor results in human efficacy studies, hampering progress in this area of research. Here we report our experience with a swine model of postinfarction MR, describe techniques to induce regurgitation and perform open-heart surgery in these diseased animals, and discuss our outcomes, complications, and solutions.
authors.affiliation: Structural Heart Disease Research and Innovation Laboratory, Division of Cardiothoracic Surgery, Carlyle Fraser Heart Center, Emory University, Atlanta, Georgia, USA.
authors.forename: Eric L
authors.initials: EL
authors.lastname: Sarin
authors.affiliation: Structural Heart Disease Research and Innovation Laboratory, Division of Cardiothoracic Surgery, Carlyle Fraser Heart Center, Emory University, Atlanta, Georgia, USA.
authors.forename: Weiwei
authors.initials: W
authors.lastname: Shi
authors.affiliation: Structural Heart Disease Research and Innovation Laboratory, Division of Cardiothoracic Surgery, Carlyle Fraser Heart Center, Emory University, Atlanta, Georgia, USA.
authors.forename: Rajnish
authors.initials: R
authors.lastname: Duara
authors.affiliation: Cardiac Perfusion Services, Emory Healthcare, Atlanta, Georgia, USA.
authors.forename: Todd A
authors.initials: TA
authors.lastname: Melone
authors.affiliation: Structural Heart Disease Research and Innovation Laboratory, Division of Cardiothoracic Surgery, Carlyle Fraser Heart Center, Emory University, Atlanta, Georgia, USA.
authors.forename: Kanika
authors.initials: K
authors.lastname: Kalra
authors.affiliation: Structural Heart Disease Research and Innovation Laboratory, Division of Cardiothoracic Surgery, Carlyle Fraser Heart Center, Emory University, Atlanta, Georgia, USA.
authors.forename: Ashley
authors.initials: A
authors.lastname: Strong
authors.affiliation: Structural Heart Disease Research and Innovation Laboratory, Division of Cardiothoracic Surgery, Carlyle Fraser Heart Center, Emory University, Atlanta, Georgia, USA.
authors.forename: Apoorva
authors.initials: A
authors.lastname: Girish
authors.affiliation: Structural Heart Disease Research and Innovation Laboratory, Division of Cardiothoracic Surgery, Carlyle Fraser Heart Center, Emory University, Atlanta, Georgia, USA.
authors.forename: Bryant V
authors.initials: BV
authors.lastname: McIver
authors.affiliation: Structural Heart Disease Research and Innovation Laboratory, Division of Cardiothoracic Surgery, Carlyle Fraser Heart Center, Emory University, Atlanta, Georgia, USA.
authors.forename: Vinod H
authors.initials: VH
authors.lastname: Thourani
authors.affiliation: Structural Heart Disease Research and Innovation Laboratory, Division of Cardiothoracic Surgery, Carlyle Fraser Heart Center, Emory University, Atlanta, Georgia, USA.
authors.forename: Robert A
authors.initials: RA
authors.lastname: Guyton
authors.affiliation: Structural Heart Disease Research and Innovation Laboratory, Division of Cardiothoracic Surgery, Carlyle Fraser Heart Center, Emory University, Atlanta, Georgia, USA. spadala@emory.edu.
authors.forename: Muralidhar
authors.initials: M
authors.lastname: Padala
mesh_terms: D000818:Animals; D058385:Cardiac Valve Annuloplasty; D002315:Cardiopulmonary Bypass; D004195:Disease Models, Animal; D018618:Echocardiography, Doppler, Color; D005260:Female; D005471:Fluoroscopy; D008944:Mitral Valve Insufficiency / Q000000981:diagnostic imaging / Q000209:etiology* / Q000601:surgery*; D008953:Models, Anatomic; D009203:Myocardial Infarction / Q000150:complications* / Q000000981:diagnostic imaging / Q000209:etiology; D034421:Sus scrofa / Q000601:surgery*