title: In Vitro Activity of Isavuconazole against Rasamsonia Species.
abstract: The in vitro susceptibilities to the novel triazole isavuconazole and six other antifungal agents of a large collection of Rasamsonia isolates (n = 47) belonging to seven species were determined. Isavuconazole and voriconazole had no in vitro activity (MIC, >32 mg/liter) against isolates of the Rasamsonia argillacea species complex. The echinocandins were the most potent antifungal drugs against all of the isolates tested (minimum effective concentration, ≤0.19 mg/liter).
authors.affiliation: Institute of Medical Microbiology, University Hospital Essen, University Duisburg-Essen, Essen, Germany Joerg.Steinmann@uk-essen.de.
authors.forename: J
authors.initials: J
authors.lastname: Steinmann
authors.affiliation: Institute of Medical Microbiology, University Hospital Essen, University Duisburg-Essen, Essen, Germany.
authors.forename: S
authors.initials: S
authors.lastname: Dittmer
authors.affiliation: CBS-KNAW Fungal Biodiversity Centre, Utrecht, The Netherlands.
authors.forename: J
authors.initials: J
authors.lastname: Houbraken
authors.affiliation: Institute of Medical Microbiology, University Hospital Essen, University Duisburg-Essen, Essen, Germany.
authors.forename: J
authors.initials: J
authors.lastname: Buer
authors.affiliation: Institute of Medical Microbiology, University Hospital Essen, University Duisburg-Essen, Essen, Germany.
authors.forename: P-M
authors.initials: PM
authors.lastname: Rath
mesh_terms: D000935:Antifungal Agents / Q000494:pharmacology; D054714:Echinocandins / Q000494:pharmacology; D032641:Eurotiales / Q000187:drug effects* / Q000302:isolation & purification; D006801:Humans; D008826:Microbial Sensitivity Tests; D009570:Nitriles / Q000494:pharmacology*; D011725:Pyridines / Q000494:pharmacology*; D014230:Triazoles / Q000494:pharmacology*
chemical_list: D000935:Antifungal Agents; D054714:Echinocandins; D009570:Nitriles; D011725:Pyridines; D014230:Triazoles; C508735:isavuconazole