title: Prenatal irradiation-induced brain neuropathology and cognitive impairment.
abstract: Embryo/fetus is much more radiosensitive than neonatal and adult human being. The main potential effects of pre-natal radiation exposure on the human brain include growth retardation, small head/brain size, mental retardation, neocortical ectopias, callosal agenesis and brain tumor which may result in a lifetime poor quality of life. The patterns of prenatal radiation-induced effects are dependent not only on the stages of fetal development, the sensitivity of tissues and organs, but also on radiation sources, doses, dose rates. With the increased use of low dose radiation for diagnostic or radiotherapeutic purposes in recent years, combined with postnatal negative health effect after prenatal radiation exposure to fallout of Chernobyl nuclear power plant accident, the great anxiety and unnecessary termination of pregnancies after the nuclear disaster, there is a growing concern about the health effect of radiological examinations or therapies in pregnant women. In this paper, we reviewed current research progresses on pre-natal ionizing irradiation-induced abnormal brain structure changes. Subsequent postnatal neuropsychological and neurological diseases were provided. Relationship between irradiation and brain aging was briefly mentioned. The relevant molecular mechanisms were also discussed. Future research directions were proposed at the end of this paper. With limited human data available, we hoped that systematical review of animal data could relight research interests on prenatal low dose/dose rate irradiation-induced brain microanatomical changes and subsequent neurological and neuropsychological disorders.
authors.affiliation: Medical School of Yangtze University, People's Republic of China.
authors.forename: Bo
authors.initials: B
authors.lastname: Yang
authors.affiliation: Medical School of Yangtze University, People's Republic of China. Electronic address: boxuren188@163.com.
authors.forename: Bo Xu
authors.initials: BX
authors.lastname: Ren
authors.affiliation: Radiobiology Research Laboratory, Singapore Nuclear Research and Safety Initiative (SNRSI), National University of Singapore, Singapore. Electronic address: tangfr@gmail.com.
authors.forename: Feng Ru
authors.initials: FR
authors.lastname: Tang
mesh_terms: D000818:Animals; D001921:Brain / Q000254:growth & development / Q000473:pathology* / Q000528:radiation effects*; D060825:Cognitive Dysfunction / Q000209:etiology* / Q000473:pathology*; D005260:Female; D006801:Humans; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D011832:Radiation Injuries / Q000473:pathology* / Q000523:psychology*
keywords: Brain diseases; Ionizing radiation; Neuropathology; Prenatal