title: Diastereoselective Synthesis of Cyclopenta[c]furans by a Catalytic Multicomponent Reaction.
abstract: A diastereoselective three-component reaction between alkynyl enones, aldehydes and secondary amines is reported. With the aid of a benign indium catalyst, a range of highly substituted cyclopenta[c]furan derivatives can be obtained in a single-step procedure. The formation of the stereodefined heterocyclic motifs takes place via in situ generation of enamines followed by two sequential cyclization steps.
authors.affiliation: Department of Organic Chemistry, Stockholm University, Arrhenius Laboratory, 10691, Stockholm, Sweden.
authors.forename: Stalin R
authors.identifier: 0000-0002-6536-8506
authors.initials: SR
authors.lastname: Pathipati
authors.affiliation: Department of Organic Chemistry, Stockholm University, Arrhenius Laboratory, 10691, Stockholm, Sweden.
authors.forename: Angela
authors.identifier: 0000-0001-6517-8879
authors.initials: A
authors.lastname: van der Werf
authors.affiliation: Department of Materials and Environmental Chemistry, Stockholm University, Arrhenius Laboratory, 10691, Stockholm, Sweden.
authors.forename: Lars
authors.initials: L
authors.lastname: Eriksson
authors.affiliation: Department of Organic Chemistry, Stockholm University, Arrhenius Laboratory, 10691, Stockholm, Sweden. nicklas.selander@su.se.
authors.forename: Nicklas
authors.identifier: 0000-0002-9085-0476
authors.initials: N
authors.lastname: Selander
keywords: alkynes; enones; fused-ring systems; indium catalysis; multicomponent reactions