title: In vitro genotoxicity testing-Can the performance be enhanced?
abstract: The assessment of genotoxicity represents an essential component of the safety assessment of all types of substances. Several in vitro tests are available at different stages of development and acceptance, yet they are not considered at present sufficient to fully replace animal tests needed to evaluate the safety of substances. For an overall improvement of the traditional genotoxicity testing paradigm, several recent activities have taken place. These include the improvement of existing tests, the development of novel tests, as well as, the establishment and exploration of approaches to optimise in vitro testing accuracy. Furthermore, useful tools, such as databases or reference chemical lists have been developed to support advances in this field.
authors.affiliation: European Commission, Joint Research Centre (JRC), Directorate Health, Consumers and Reference Materials, Chemicals Safety and Alternative Methods Unit, EURL ECVAM, Via E. Fermi 2749, I-21027, Ispra, Varese, Italy. Electronic address: raffaella.corvi@ec.europa.eu.
authors.forename: Raffaella
authors.initials: R
authors.lastname: Corvi
authors.affiliation: European Commission, Joint Research Centre (JRC), Directorate Health, Consumers and Reference Materials, Chemicals Safety and Alternative Methods Unit, EURL ECVAM, Via E. Fermi 2749, I-21027, Ispra, Varese, Italy. Electronic address: federica.madia@ec.europa.eu.
authors.forename: Federica
authors.initials: F
authors.lastname: Madia
mesh_terms: D000818:Animals; D004247:DNA / Q000235:genetics; D004249:DNA Damage / Q000187:drug effects; D006801:Humans; D009152:Mutagenicity Tests / Q000379:methods* / Q000592:standards; D009153:Mutagens / Q000633:toxicity*
chemical_list: D009153:Mutagens; D004247:DNA
keywords: Alternative methods; Genotoxicity; In vitro mammalian cell test; Safety assessment