title: A New DNA Methyltransferase-Histone Deacetylase-Kinase Axis in Innate Immunity.
abstract: Regulatory roles of protein and DNA modifications in gene expression during host defense have long been appreciated. In a recent article published in Nature Immunology, Li et al. (2016) provide a unique glimpse of yet another aspect of coordinated DNA methylation and protein acetylation in host response to pathogenic stimuli. They elegantly demonstrate that DNA methylation and transcriptional activation at the HDAC9 promoter by DNMT3a, along with lysine deacetylation of TBK1 by HDAC9, are essential events during host defense.
authors.affiliation: Department of Chemistry and Biochemistry, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA. Electronic address: gghosh@ucsd.edu.
authors.forename: Gourisankar
authors.initials: G
authors.lastname: Ghosh
authors.affiliation: CSIR-Indian Institute of Chemical Biology, 4 Raja SC Mullick Road, Jadavpur, Kolkata 70032, India.
authors.forename: Malini
authors.initials: M
authors.lastname: Sen
mesh_terms: D000107:Acetylation; D004247:DNA; D019175:DNA Methylation; D006655:Histone Deacetylases; D006657:Histones; D006801:Humans; D008780:Methyltransferases; D011116:Polynucleotide 5'-Hydroxyl-Kinase; D011401:Promoter Regions, Genetic; D006656:Protamine Kinase
chemical_list: D006657:Histones; D004247:DNA; D008780:Methyltransferases; D011116:Polynucleotide 5'-Hydroxyl-Kinase; D006656:Protamine Kinase; D006655:Histone Deacetylases