title: Fully synthetic self-adjuvanting MUC1-fibroblast stimulating lipopeptide 1 conjugates as potential cancer vaccines.
abstract: We have designed and synthesized MUC1-fibroblast stimulating lipopeptide 1 conjugates as potential self-adjuvanting cancer vaccines using a linear solid phase peptide synthesis strategy. These vaccine candidates have elicited T cell dependent immune response and the induced antibodies showed intense specific binding affinity to human MCF-7 cells.
authors.affiliation: State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Haihe Education Park, 38 Tongyan Road, Tianjin 300353, P. R. China. wzhao@nankai.edu.cn pwang@nankai.edu.cn.
authors.forename: Yonghui
authors.initials: Y
authors.lastname: Liu
authors.forename: Wenpeng
authors.initials: W
authors.lastname: Zhang
authors.forename: Qianqian
authors.initials: Q
authors.lastname: He
authors.forename: Fan
authors.initials: F
authors.lastname: Yu
authors.forename: Tianbang
authors.initials: T
authors.lastname: Song
authors.forename: Tingting
authors.initials: T
authors.lastname: Liu
authors.forename: Zhenqing
authors.initials: Z
authors.lastname: Zhang
authors.forename: Jun
authors.initials: J
authors.lastname: Zhou
authors.forename: Peng George
authors.initials: PG
authors.lastname: Wang
authors.forename: Wei
authors.initials: W
authors.lastname: Zhao
mesh_terms: D000276:Adjuvants, Immunologic; D000595:Amino Acid Sequence; D000818:Animals; D000906:Antibodies / Q000276:immunology / Q000378:metabolism; D001426:Bacterial Proteins / Q000737:chemistry* / Q000276:immunology; D019496:Cancer Vaccines / Q000138:chemical synthesis / Q000737:chemistry* / Q000276:immunology; D016207:Cytokines / Q000032:analysis / Q000378:metabolism; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D008222:Lymphokines / Q000737:chemistry* / Q000276:immunology; D061986:MCF-7 Cells; D051379:Mice; D018396:Mucin-1 / Q000737:chemistry* / Q000276:immunology; D045804:Mycoplasma salivarium / Q000378:metabolism; D009369:Neoplasms / Q000276:immunology / Q000473:pathology / Q000517:prevention & control; D060327:Solid-Phase Synthesis Techniques; D013601:T-Lymphocytes / Q000166:cytology / Q000276:immunology / Q000378:metabolism
chemical_list: D000276:Adjuvants, Immunologic; D000906:Antibodies; D001426:Bacterial Proteins; D019496:Cancer Vaccines; D016207:Cytokines; D008222:Lymphokines; D018396:Mucin-1; C085978:fibroblast stimulating factor-1