title: Increased PI3K/Akt activity and deregulated humoral immune response in human PTEN deficiency.
authors.affiliation: Department of Pediatric Infectious Disease and Immunology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands; Department of Immunology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
authors.forename: Gertjan J
authors.initials: GJ
authors.lastname: Driessen
authors.affiliation: Department of Immunology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
authors.forename: Hanna
authors.initials: H
authors.lastname: IJspeert
authors.affiliation: Department of Immunology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
authors.forename: Marjolein
authors.initials: M
authors.lastname: Wentink
authors.affiliation: Deparment of Human Genetics, Radboud University Medical Center, Nijmegen, The Netherlands.
authors.forename: Helger G
authors.initials: HG
authors.lastname: Yntema
authors.affiliation: Department of Immunology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
authors.forename: P Martin
authors.initials: PM
authors.lastname: van Hagen
authors.affiliation: Department of Immunology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
authors.forename: Arthur
authors.initials: A
authors.lastname: van Strien
authors.affiliation: Department of Women and Children Health, Division of Pediatrics, University of Padova, Padova, Italy.
authors.forename: Giorgia
authors.initials: G
authors.lastname: Bucciol
authors.affiliation: Faculty of Medicine, Department of Pediatrics, Division of Genetics, Ege University, Izmir, Turkey.
authors.forename: Ozgur
authors.initials: O
authors.lastname: Cogulu
authors.affiliation: Department of Immunology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
authors.forename: Margreet
authors.initials: M
authors.lastname: Trip
authors.affiliation: Deparment of Human Genetics, Radboud University Medical Center, Nijmegen, The Netherlands.
authors.forename: Willy
authors.initials: W
authors.lastname: Nillesen
authors.affiliation: Juliana Children's Hospital, Den Haag, The Netherlands.
authors.forename: Els A
authors.initials: EA
authors.lastname: Peeters
authors.affiliation: Department of Immunology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
authors.forename: Ingrid
authors.initials: I
authors.lastname: Pico-Knijnenburg
authors.affiliation: Department of Immunology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
authors.forename: Barbara H
authors.initials: BH
authors.lastname: Barendregt
authors.affiliation: Center for Chronic Immunodeficiency, University Medical Center Freiburg and University of Freiburg, Freiburg, Germany.
authors.forename: Marta
authors.initials: M
authors.lastname: Rizzi
authors.affiliation: Department of Immunology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
authors.forename: Jacques J
authors.initials: JJ
authors.lastname: van Dongen
authors.affiliation: Faculty of Medicine, Department of Pediatrics, Division of Pediatric Immunology, Ege University, Izmir, Turkey.
authors.forename: Necil
authors.initials: N
authors.lastname: Kutukculer
authors.affiliation: Department of Immunology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands. Electronic address: m.vanderburg@erasmusmc.nl.
authors.forename: Mirjam
authors.initials: M
authors.lastname: van der Burg
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D056724:Immunity, Humoral / Q000276:immunology*; D051059:PTEN Phosphohydrolase / Q000172:deficiency* / Q000276:immunology / Q000378:metabolism; D019869:Phosphatidylinositol 3-Kinases / Q000378:metabolism*; D051057:Proto-Oncogene Proteins c-akt / Q000378:metabolism*
chemical_list: D019869:Phosphatidylinositol 3-Kinases; D051057:Proto-Oncogene Proteins c-akt; D051059:PTEN Phosphohydrolase; C494929:PTEN protein, human