title: High-Stakes Systematic Reviews: A Case Study From the Field of Teen Pregnancy Prevention.
abstract: BACKGROUND
  Systematic reviews help policy makers and practitioners make sense of research findings in a particular program, policy, or practice area by synthesizing evidence across multiple studies. However, the link between review findings and practical decision-making is rarely one-to-one. Policy makers and practitioners may use systematic review findings to help guide their decisions, but they may also rely on other information sources or personal judgment.
  
  
  OBJECTIVE
  To describe a recent effort by the U.S. federal government to narrow the gap between review findings and practical decision-making. The Teen Pregnancy Prevention (TPP) Evidence Review was launched by the U.S. Department of Health and Human Services (HHS) in 2009 as a systematic review of the TPP literature. HHS has used the review findings to determine eligibility for federal funding for TPP programs, marking one of the first attempts to directly link systematic review findings with federal funding decisions.
  
  
  CONCLUSIONS
  The high stakes attached to the review findings required special considerations in designing and conducting the review. To provide a sound basis for federal funding decisions, the review had to meet accepted methodological standards. However, the review team also had to account for practical constraints of the funding legislation and needs of the federal agencies responsible for administering the grant programs. The review team also had to develop a transparent process for both releasing the review findings and updating them over time. Prospective review authors and sponsors must recognize both the strengths and limitations of this approach before applying it in other areas.
authors.affiliation: 1 Mathematica Policy Research, Princeton, NJ, USA.
authors.forename: Brian
authors.initials: B
authors.lastname: Goesling
authors.affiliation: 2 U.S. Department of Health and Human Services (HHS)/Office of the Assistant Secretary for Planning and Evaluation (ASPE), Washington, DC, USA.
authors.forename: Sarah
authors.initials: S
authors.lastname: Oberlander
authors.affiliation: 2 U.S. Department of Health and Human Services (HHS)/Office of the Assistant Secretary for Planning and Evaluation (ASPE), Washington, DC, USA.
authors.forename: Lisa
authors.initials: L
authors.lastname: Trivits
keywords: federal grant funding; systematic review; teen pregnancy prevention