title: An unusual case of IgA-dominant postinfectious glomerulonephritis: a case report and review of the literature.
abstract: We report a case of IgA-dominant postinfectious glomerulonephritis in a 49-year-old man presenting with acute kidney injury, nephrotic range proteinuria and hematuria. He suffered from ischemic heart disease, cardiac insufficiency, mitral regurgitation, tricuspid insufficiency, septal aneurysm and hypertension. Renal biopsy revealed segmental and focal endocapillary and mesangial hypercellularity, and thickening of the glomerular capillary wall. Immunofluorescence showed co-dominant strong coarse granular immunostaining of IgA, IgG and C3 mainly along the glomerular capillary wall. On electron microscopy some large subepithelial hump-shaped deposits were present. In summary, this case demonstrates the presence of a broad spectrum of glomerular histological findings in postinfectious glomerulonephritis.
authors.affiliation: Małgorzata Wągrowska-Danilewicz MD, PhD, Department of Nephropathology, Medical University of Lodz, Pomorska 251, 92-216 Lodz, Poland, tel./fax +48 42 675 76 33, e-mail: malgorzata.wagrowska-danilewicz@umed.lodz.pl.
authors.forename: M
authors.initials: M
authors.lastname: Wagrowska-Danilewicz
authors.forename: M
authors.initials: M
authors.lastname: Danilewicz
authors.forename: I
authors.initials: I
authors.lastname: Fisiak
authors.forename: J
authors.initials: J
authors.lastname: Piskorska
mesh_terms: D005455:Fluorescent Antibody Technique; D005922:Glomerulonephritis, IGA / Q000473:pathology*; D006801:Humans; D008297:Male; D008854:Microscopy, Electron; D008875:Middle Aged