title: Local Recurrence of Extremity Soft Tissue Sarcoma.
abstract: The management of recurrent soft tissue sarcoma is a challenging problem for clinicians and has a significant physical, mental, emotional, and oncologic impact for the patient. Despite excellent limb-preservation therapies, approximately one-quarter of patients may eventually develop recurrence of disease. How to most appropriately manage these patients is a matter of debate. Several treatment options exist, including surgical resection, irradiation, systemic chemotherapy, amputation, and regional therapies. This article highlights the management of recurrent extremity soft tissue sarcoma.
authors.affiliation: Department of Surgery, University of Tennessee Health Science Center, 910 Madison Ave, Suite 300, Memphis, TN 38163, USA.
authors.forename: Whitney M
authors.initials: WM
authors.lastname: Guerrero
authors.affiliation: Department of Surgery, University of Tennessee Health Science Center, 910 Madison Ave, Suite 300, Memphis, TN 38163, USA; Division of Surgical Oncology, University of Tennessee Health Science Center, 910 Madison Avenue, Suite 300, Memphis, TN 38163, USA. Electronic address: jdeneve@uthsc.edu.
authors.forename: Jeremiah L
authors.initials: JL
authors.lastname: Deneve
mesh_terms: D003131:Combined Modality Therapy; D019468:Disease Management; D005121:Extremities; D006801:Humans; D009364:Neoplasm Recurrence, Local / Q000517:prevention & control*; D012509:Sarcoma / Q000628:therapy*
keywords: Amputation; Hyperthermic isolated limb perfusion; Isolated limb infusion; Limb salvage; Metastasis; Radiation; Recurrence; Sarcoma