title: Osseointegration aspects of placed implant in bone reconstruction with newly developed block-type interconnected porous calcium hydroxyapatite.
abstract: OBJECTIVE
  The purpose of this study was to evaluate the osseointegration of dental implant in bone reconstructions with interconnected porous calcium hydroxyapatite (IP-CHA).
  
  
  METHODS
  The IP-CHA cylinders (D; 4.3 mm, H; 10.0 mm) were placed into bone sockets in each side of the femurs of four male dogs. The IP-CHA on the right side was a 24-week sample. Twelve weeks after placement, a titanium implant was placed into a socket that was prepared in half of the placed IP-CHA cylinder on the right side. On the left side, another IP-CHA cylinder was placed as a 12-week sample. After another 12 weeks, the samples were harvested, and the bone regeneration and bone-implant contact (BIC) ratios were measured.
  
  
  RESULTS
  New bone formation area was superior in the 24-week IP-CHA compared with the 12-week IP-CHA. BIC was not significantly different between IP-CHA and the parent sites. Osseointegration was detected around the implant in IP-CHA-reconstructed bone.
  
  
  CONCLUSIONS
  Our preliminary results suggest that IP-CHA may be a suitable bone graft material for reconstructing bones that require implant placement.
authors.affiliation: Hiroshima University Graduate School of Biomedical and Health Sciences.
authors.forename: Kazuya
authors.initials: K
authors.lastname: Doi
authors.affiliation: Hiroshima University Graduate School of Biomedical and Health Sciences.
authors.forename: Takayasu
authors.initials: T
authors.lastname: Kubo
authors.affiliation: Hiroshima University Graduate School of Biomedical and Health Sciences.
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Makihara
authors.affiliation: Hiroshima University Graduate School of Biomedical and Health Sciences.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Oue
authors.affiliation: Hiroshima University Graduate School of Biomedical and Health Sciences.
authors.forename: Koji
authors.initials: K
authors.lastname: Morita
authors.affiliation: Hiroshima University Graduate School of Biomedical and Health Sciences.
authors.forename: Yoshifumi
authors.initials: Y
authors.lastname: Oki
authors.affiliation: Hiroshima University Graduate School of Biomedical and Health Sciences.
authors.forename: Shiho
authors.initials: S
authors.lastname: Kajihara
authors.affiliation: Hiroshima University Graduate School of Biomedical and Health Sciences.
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Tsuga
mesh_terms: D000818:Animals; D018786:Bone Substitutes / Q000494:pharmacology*; D016025:Bone Transplantation / Q000379:methods*; D003758:Dental Implantation, Endosseous / Q000379:methods*; D017267:Dental Prosthesis Design; D004285:Dogs; D017886:Durapatite / Q000494:pharmacology*; D005269:Femur / Q000601:surgery; D020007:Implants, Experimental; D008297:Male; D008422:Materials Testing; D008855:Microscopy, Electron, Scanning; D016348:Osseointegration / Q000187:drug effects*; D015203:Reproducibility of Results; D013499:Surface Properties; D013997:Time Factors; D014025:Titanium / Q000737:chemistry
chemical_list: D018786:Bone Substitutes; D017886:Durapatite; D014025:Titanium