title: Effects of Renal Denervation Documented in the Austrian National Multicentre Renal Denervation Registry.
abstract: Renal denervation (RDN) is a new procedure for treatment-resistant hypertensive patients. In order to monitor all procedures undergone in Austria, the Austrian Society of Hypertension established the investigator-initiated Austrian Transcatheter Renal Denervation (TREND) Registry. From April 2011 to September 2014, 407 procedures in 14 Austrian centres were recorded. At baseline, office and mean 24-h ambulatory blood pressure (ABP) were 171/94 and 151/89 mmHg, respectively, and patients were taking a median of 4 antihypertensive medications. Mean 24-h ABP changes after 2-6 weeks, 3, 6 and 12 months were -11/-6, -8/-4, -8/-5 and -10/-6 mmHg (p<0.05 at all measurements), respectively. The periprocedural complication rate was 2.5%. Incidence of long-term complications during follow-up (median 1 year) was 0.5%. Office BP and ABP responses showed only a weak correlation (Pearson coefficient 0.303). Based on the data from the TREND registry, ambulatory blood pressure monitoring in addition to office BP should be used for patient selection as well as for monitoring response to RDN. Furthermore, criteria for optimal patient selection are suggested.
authors.affiliation: Division of Cardiology, Department of Internal Medicine, Medical University Graz, Graz, Austria.
authors.forename: David
authors.identifier: http://orcid.org/0000-0002-7479-7767
authors.initials: D
authors.lastname: Zweiker
authors.affiliation: Department of Internal Medicine I, Kepler University Hospital, Linz, Austria.
authors.forename: Thomas
authors.initials: T
authors.lastname: Lambert
authors.affiliation: Department of Internal Medicine I, Kepler University Hospital, Linz, Austria.|Department of Internal Medicine II, Paracelsus Medical University Salzburg, Salzburg, Austria.
authors.forename: Clemens
authors.initials: C
authors.lastname: Steinwender
authors.affiliation: Department of Internal Medicine II, Klinikum Wels-Grieskirchen, Wels, Austria.
authors.forename: Thomas
authors.initials: T
authors.lastname: Weber
authors.affiliation: Department of Internal Medicine II, Klinikum Wels-Grieskirchen, Wels, Austria.
authors.forename: Markus
authors.initials: M
authors.lastname: Suppan
authors.affiliation: Division of Cardiology, Department of Internal Medicine, Medical University Graz, Graz, Austria.
authors.forename: Helmut
authors.initials: H
authors.lastname: Brussee
authors.affiliation: Department of Internal Medicine III, Medizinische Universität Innsbruck, Innsbruck, Austria.
authors.forename: Christian
authors.initials: C
authors.lastname: Koppelstätter
authors.affiliation: Department of Internal Medicine IV, Medizinische Universität Innsbruck, Innsbruck, Austria.
authors.forename: Julia
authors.initials: J
authors.lastname: Kerschbaum
authors.affiliation: Division of Nephrology, Department of Internal Medicine III, Medical University Vienna, Vienna, Austria.
authors.forename: Bruno
authors.initials: B
authors.lastname: Watschinger
authors.affiliation: Division of Nephrology, Department of Internal Medicine III, Medical University Vienna, Vienna, Austria.
authors.forename: Katharina
authors.initials: K
authors.lastname: Hohenstein-Scheibenecker
authors.affiliation: Division of Nephrology, Department of Internal Medicine III, Medical University Vienna, Vienna, Austria.|Department of Internal Medicine II, Krankenhaus der Elisabethinen Linz, Linz, Austria.
authors.forename: Roman
authors.initials: R
authors.lastname: Reindl-Schwaighofer
authors.affiliation: Department of Internal Medicine II, Krankenhaus der Elisabethinen Linz, Linz, Austria.
authors.forename: Thomas
authors.initials: T
authors.lastname: Sturmberger
authors.affiliation: Department of Internal Medicine, Landeskrankenhaus Waidhofen an der Ybbs, Waidhofen/Ybbs, Austria.
authors.forename: Claudia
authors.initials: C
authors.lastname: Kindslehner
authors.affiliation: Third Department of Internal Medicine, Wilhelminenspital and Medical Faculty, Sigmund Freud University, Vienna, Austria.|Medical Faculty, Sigmund Freud University, Vienna, Austria.
authors.forename: Thomas Werner
authors.initials: TW
authors.lastname: Weiss
authors.affiliation: Third Department of Internal Medicine, Wilhelminenspital and Medical Faculty, Sigmund Freud University, Vienna, Austria.
authors.forename: Miklos
authors.initials: M
authors.lastname: Rohla
authors.affiliation: Department of Internal Medicine II, Paracelsus Medical University Salzburg, Salzburg, Austria.
authors.forename: Peter
authors.initials: P
authors.lastname: Gruener
authors.affiliation: Department of Internal Medicine I, Krankenhaus St. Josef Braunau, Braunau, Austria.
authors.forename: Petra
authors.initials: P
authors.lastname: Maister
authors.affiliation: Department of Internal Medicine I, Krankenhaus St. Josef Braunau, Braunau, Austria.
authors.forename: Johann
authors.initials: J
authors.lastname: Auer
authors.affiliation: Fifth Medical Department, Kaiser-Franz-Josef-Spital, Vienna, Austria.
authors.forename: Cornelia
authors.initials: C
authors.lastname: Dechant
authors.affiliation: Department of Internal Medicine, Privatklinik Mariahilf, Klagenfurt, Austria.
authors.forename: Josef
authors.initials: J
authors.lastname: Sykora
authors.affiliation: Department of Internal Medicine, Krankenhaus St. Vinzenz, Zams, Austria.
authors.forename: Christoph
authors.initials: C
authors.lastname: Krismer
authors.affiliation: Department of Internal Medicine II, Landesklinikum Wiener Neustadt, Wiener Neustadt, Austria.
authors.forename: Stefan
authors.initials: S
authors.lastname: Glaser
authors.affiliation: Division of Cardiology, Department of Internal Medicine, Medical University Graz, Graz, Austria.
authors.forename: Robert
authors.initials: R
authors.lastname: Zweiker
mesh_terms: D055011:Ablation Techniques; D000368:Aged; D001317:Austria; D018660:Blood Pressure Monitoring, Ambulatory; D003714:Denervation / Q000009:adverse effects; D004282:Documentation; D005260:Female; D006801:Humans; D006973:Hypertension / Q000503:physiopathology / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D012042:Registries; D012077:Renal Artery / Q000294:innervation* / Q000601:surgery*; D012449:Safety; D016896:Treatment Outcome