title: The critical roles of mitophagy in cerebral ischemia.
abstract: Mitochondria play a key role in various cell processes including ATP production, Ca2+homeostasis, reactive oxygen species (ROS) generation, and apoptosis. The selective removal of impaired mitochondria by autophagosome is known as mitophagy. Cerebral ischemia is a common form of stroke caused by insufficient blood supply to the brain. Emerging evidence suggests that mitophagy plays important roles in the pathophysiological process of cerebral ischemia. This review focuses on the relationship between ischemic brain injury and mitophagy. Based on the latest research, it describes how the signaling pathways of mitophagy appear to be involved in cerebral ischemia.
authors.affiliation: School of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong, Hong Kong, China.
authors.forename: Yan-Cheng
authors.initials: YC
authors.lastname: Tang
authors.affiliation: Medical Research Department, Guangdong General Hospital and Guangdong Academy of Medical Sciences, Guangzhou, 510080, China.
authors.forename: Hong-Xia
authors.initials: HX
authors.lastname: Tian
authors.affiliation: School of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong, Hong Kong, China. yitao@hkbu.edu.hk.|HKBU Institute of Research and Continuing Education, Shenzhen, 518057, China. yitao@hkbu.edu.hk.
authors.forename: Tao
authors.identifier: http://orcid.org/0000-0002-4089-3611
authors.initials: T
authors.lastname: Yi
authors.affiliation: School of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong, Hong Kong, China. hbchen@hkbu.edu.hk.
authors.forename: Hu-Biao
authors.initials: HB
authors.lastname: Chen
mesh_terms: D000818:Animals; D002545:Brain Ischemia / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D063306:Mitophagy; D017382:Reactive Oxygen Species / Q000378:metabolism*; D020521:Stroke / Q000378:metabolism* / Q000473:pathology
chemical_list: D017382:Reactive Oxygen Species
keywords: autophagy; cerebral ischemia; mitochondria; mitophagy