title: INGs are potential drug targets for cancer.
abstract: OBJECTIVE
  The inhibitor of growth (ING) family consists of ING1, ING2, ING3, ING4 and ING5, which function as the type II tumor suppressors. INGs regulate cell proliferation, senescence, apoptosis, differentiation, angiogenesis, DNA repair, metastasis, and invasion by multiple pathways. In addition, INGs increase cancer cell sensitivity for chemotherapy and radiotherapy, while clinical observations show that INGs are frequently lost in some types of cancers. The aim of the study was to summarize the recent progress regarding INGs regulating tumor progression.
  
  
  METHODS
  The literatures of INGs regulating tumor progression were searched and assayed.
  
  
  RESULTS
  The regulating signaling pathways of ING1, ING2, ING3 or ING4 on tumor progression were shown. The mechanisms of INGs on tumor suppression were also assayed.
  
  
  CONCLUSIONS
  This review better summarized the signaling mechanism of INGs on tumor suppression, which provides a candidate therapy strategy for cancers.
authors.affiliation: Department of Oncology, Affiliated Wujin People's Hospital, Jiangsu University, Changzhou, 212017, People's Republic of China.|Institute of Life Sciences, Jiangsu University, Zhenjiang, 212013, People's Republic of China.
authors.forename: Runyun
authors.initials: R
authors.lastname: Zhang
authors.affiliation: Department of Oncology, Affiliated Wujin People's Hospital, Jiangsu University, Changzhou, 212017, People's Republic of China.
authors.forename: Jianhua
authors.initials: J
authors.lastname: Jin
authors.affiliation: Institute of Life Sciences, Jiangsu University, Zhenjiang, 212013, People's Republic of China. sjj@ujs.edu.cn.
authors.forename: Juanjuan
authors.initials: J
authors.lastname: Shi
authors.affiliation: Department of Oncology, Affiliated Wujin People's Hospital, Jiangsu University, Changzhou, 212017, People's Republic of China. houyz@ujs.edu.cn.|Institute of Life Sciences, Jiangsu University, Zhenjiang, 212013, People's Republic of China. houyz@ujs.edu.cn.
authors.forename: Yongzhong
authors.initials: Y
authors.lastname: Hou
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology* / Q000627:therapeutic use; D018797:Cell Cycle Proteins / Q000037:antagonists & inhibitors / Q000502:physiology*; D049109:Cell Proliferation; D015972:Gene Expression Regulation, Neoplastic / Q000187:drug effects; D018398:Homeodomain Proteins / Q000037:antagonists & inhibitors / Q000502:physiology*; D006801:Humans; D058990:Molecular Targeted Therapy; D009369:Neoplasms / Q000188:drug therapy* / Q000473:pathology; D025521:Tumor Suppressor Proteins / Q000037:antagonists & inhibitors / Q000502:physiology*
chemical_list: D000970:Antineoplastic Agents; D018797:Cell Cycle Proteins; D018398:Homeodomain Proteins; C483230:ING4 protein, human; D025521:Tumor Suppressor Proteins
keywords: Cancer therapy; Cell signaling; INGs; Tumor suppressors