title: Epidermal Growth Factor and Intestinal Barrier Function.
abstract: Epidermal growth factor (EGF) is a 53-amino acid peptide that plays an important role in regulating cell growth, survival, migration, apoptosis, proliferation, and differentiation. In addition, EGF has been established to be an effective intestinal regulator helping to protect intestinal barrier integrity, which was essential for the absorption of nutrients and health in humans and animals. Several researches have demonstrated that EGF via binding to the EGF receptor and subsequent activation of Ras/MAPK, PI3K/AKT, PLC-γ/PKC, and STATS signal pathways regulates intestinal barrier function. In this review, the relationship between epidermal growth factor and intestinal development and intestinal barrier is described, to provide a better understanding of the effects of EGF on intestine development and health.
authors.affiliation: College of Animal Science and Technology, Hunan Agricultural University, Changsha 410128, China; Hunan Co-Innovation Center of Animal Production Safety, Changsha 410128, China.
authors.forename: Xiaopeng
authors.identifier: 0000-0002-4789-5687
authors.initials: X
authors.lastname: Tang
authors.affiliation: College of Animal Science and Technology, Hunan Agricultural University, Changsha 410128, China; Hunan Co-Innovation Center of Animal Production Safety, Changsha 410128, China.
authors.forename: Hu
authors.initials: H
authors.lastname: Liu
authors.affiliation: College of Animal Science and Technology, Hunan Agricultural University, Changsha 410128, China; Hunan Co-Innovation Center of Animal Production Safety, Changsha 410128, China.
authors.forename: Shufen
authors.initials: S
authors.lastname: Yang
authors.affiliation: College of Animal Science and Technology, Hunan Agricultural University, Changsha 410128, China; Hunan Co-Innovation Center of Animal Production Safety, Changsha 410128, China.
authors.forename: Zuohua
authors.initials: Z
authors.lastname: Li
authors.affiliation: College of Animal Science and Technology, Hunan Agricultural University, Changsha 410128, China; Hunan Co-Innovation Center of Animal Production Safety, Changsha 410128, China; Hunan Polytechnic of Environment and Biology, Hengyang 421005, China.
authors.forename: Jinfeng
authors.initials: J
authors.lastname: Zhong
authors.affiliation: College of Animal Science and Technology, Hunan Agricultural University, Changsha 410128, China; Hunan Co-Innovation Center of Animal Production Safety, Changsha 410128, China.
authors.forename: Rejun
authors.identifier: 0000-0003-2027-7739
authors.initials: R
authors.lastname: Fang
mesh_terms: D000818:Animals; D004815:Epidermal Growth Factor / Q000378:metabolism*; D066246:ErbB Receptors / Q000378:metabolism; D006801:Humans; D007413:Intestinal Mucosa / Q000378:metabolism*; D050791:STAT Transcription Factors / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology
chemical_list: D050791:STAT Transcription Factors; D004815:Epidermal Growth Factor; D066246:ErbB Receptors