title: Mortality in Captive Rhesus Monkeys (Macaca mulatta) in China Due to Infection with Yersinia pseudotuberculosis Serotype O:1a.
abstract: The most common serotypes of Yersinia pseudotuberculosis infecting non-human primates are serotypes O:1b, O:3, O:4, and O:7. The O:1a serotype has never been reported in non-human primates. The present study describes an outbreak of serotype O:1a with high fatality (6/18) in captive rhesus monkeys in China. Bacteria were isolated from different organs of the carcasses using standard microbiological procedures. The strain was identified using conventional and molecular techniques such as morphological and biochemical identification, serotype determination, PCR-sequence analysis based on the 16S rRNA gene, detection of virulence genes, and antimicrobial susceptibility testing. The pathogenicity was determined after experimental infection in mice. Taken together, the obtained data indicate that Y. pseudotuberculosis O:1a is a pathogen of concern and represents a potential threat to monkey conservation efforts.
authors.affiliation: National Research Center for Wildlife-Borne Diseases, Institute of Zoology, Chinese Academy of Sciences, No. 1-5 Beichenxi Road, Chaoyang District, Beijing, 100101, People's Republic of China.|University of Chinese Academy of Sciences, No. 1-5 Beichenxi Road, Chaoyang District, Beijing, 100101, People's Republic of China.
authors.forename: Na
authors.initials: N
authors.lastname: Zhao
authors.affiliation: National Research Center for Wildlife-Borne Diseases, Institute of Zoology, Chinese Academy of Sciences, No. 1-5 Beichenxi Road, Chaoyang District, Beijing, 100101, People's Republic of China.|University of Chinese Academy of Sciences, No. 1-5 Beichenxi Road, Chaoyang District, Beijing, 100101, People's Republic of China.
authors.forename: Meng
authors.initials: M
authors.lastname: Li
authors.affiliation: Department of Zoology, Faculty of Science, Kafr El Sheikh University, Kafr El Sheikh, 33516, Egypt.
authors.forename: Said
authors.initials: S
authors.lastname: Amer
authors.affiliation: Zhejiang Provincial Centre for Disease Control and Prevention, Hangzhou, 310051, Zhejiang Province, People's Republic of China.
authors.forename: Shelan
authors.initials: S
authors.lastname: Liu
authors.affiliation: National Research Center for Wildlife-Borne Diseases, Institute of Zoology, Chinese Academy of Sciences, No. 1-5 Beichenxi Road, Chaoyang District, Beijing, 100101, People's Republic of China.
authors.forename: Jing
authors.initials: J
authors.lastname: Luo
authors.affiliation: National Research Center for Wildlife-Borne Diseases, Institute of Zoology, Chinese Academy of Sciences, No. 1-5 Beichenxi Road, Chaoyang District, Beijing, 100101, People's Republic of China.
authors.forename: Shan
authors.initials: S
authors.lastname: Wang
authors.affiliation: National Research Center for Wildlife-Borne Diseases, Institute of Zoology, Chinese Academy of Sciences, No. 1-5 Beichenxi Road, Chaoyang District, Beijing, 100101, People's Republic of China. hehx@ioz.ac.cn.
authors.forename: Hongxuan
authors.initials: H
authors.lastname: He
mesh_terms: D000818:Animals; D002681:China; D006801:Humans; D008253:Macaca mulatta / Q000382:microbiology*; D051379:Mice; D012336:RNA, Ribosomal, 16S; D065288:Serogroup; D015011:Yersinia pseudotuberculosis / Q000472:pathogenicity*; D015012:Yersinia pseudotuberculosis Infections / Q000662:veterinary*
chemical_list: D012336:RNA, Ribosomal, 16S
keywords: Rhesus monkey; Serotype O:1a; antimicrobial; resistant; yersinia pseudotuberculosis