title: Steroid Sulfates from Ophiuroids (Brittle Stars): Action on Some Factors of Innate and Adaptive Immunity.
abstract: The action of seven polyhydroxylated sterol mono- and disulfates (1-7), isolated from ophiuroids, on innate and adaptive immunity was examined in in vitro and in vivo experiments. At least, three of them (1, 2 and 4) increased the functional activities of neutrophils, including levels of oxygen-dependent metabolism, adhesive and phagocytic properties, and induced the expression of pro-inflammatory cytokines TNF-α and IL-8. Compound 4 was the most active for enhancing the production of antibody forming cells in the mouse spleen.
authors.forename: Anna K
authors.initials: AK
authors.lastname: Gazha
authors.forename: Lyudmila A
authors.initials: LA
authors.lastname: Ivanushko
authors.forename: Eleonora V
authors.initials: EV
authors.lastname: Levina
authors.forename: Sergey N
authors.initials: SN
authors.lastname: Fedorov
authors.forename: Tatyana S
authors.initials: TS
authors.lastname: Zaporozets
authors.forename: Valentin A
authors.initials: VA
authors.lastname: Stonik
authors.forename: Nataliya N
authors.initials: NN
authors.lastname: Besednova
mesh_terms: D056704:Adaptive Immunity / Q000187:drug effects*; D000818:Animals; D002478:Cells, Cultured; D016207:Cytokines / Q000235:genetics / Q000276:immunology; D056890:Eukaryota / Q000737:chemistry*; D007113:Immunity, Innate / Q000187:drug effects*; D007155:Immunologic Factors / Q000737:chemistry / Q000494:pharmacology*; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D009504:Neutrophils / Q000187:drug effects / Q000276:immunology; D013256:Steroids / Q000737:chemistry / Q000494:pharmacology*; D013431:Sulfates / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D016207:Cytokines; D007155:Immunologic Factors; D013256:Steroids; D013431:Sulfates