title: Clinical efficacy and safety of autologous stem cell transplantation for patients with ST-segment elevation myocardial infarction.
abstract: OBJECTIVE
  The purpose of this study is to evaluate the therapeutic efficacy and safety of stem cells for the treatment of patients with ST-segment elevation myocardial infarction (STEMI).
  
  
  METHODS
  We performed a systematic review and meta-analysis of relevant published clinical studies. A computerized search was conducted for randomized controlled trials of stem cell therapy for STEMI.
  
  
  RESULTS
  Twenty-eight randomized controlled trials with a total of 1,938 STEMI patients were included in the present meta-analysis. Stem cell therapy resulted in an improvement in long-term (12 months) left ventricular ejection fraction of 3.15% (95% confidence interval 1.01-5.29, P<0.01). The 3-month to 4-month, 6-month, and 12-month left ventricular end-systolic volume showed favorable results in the stem cell therapy group compared with the control group (P≤0.05). Significant decrease was also observed in left ventricular end-diastolic volume after 3-month to 4-month and 12-month follow-up compared with controls (P<0.05). Wall mean score index was reduced significantly in stem cell therapy group when compared with the control group at 6-month and 12-month follow-up (P=0.01). Moreover, our analysis showed a significant change of 12-month infarct size decrease in STEMI patients treated with stem cells compared with controls (P<0.01). In addition, no significant difference was found between treatment group and control in adverse reactions (P>0.05).
  
  
  CONCLUSIONS
  Overall, stem cell therapy is efficacious in the treatment of patients with STEMI, with low rates of adverse events compared with control group patients.
authors.affiliation: Department of Intensive Care Unit, The People's Hospital of Baoji City.
authors.forename: Rong
authors.initials: R
authors.lastname: Li
authors.affiliation: Department of Cardiovascular Medicine.
authors.forename: Xiao-Ming
authors.initials: XM
authors.lastname: Li
authors.affiliation: Department of Function, Baoji Central Hospital, Baoji, Shaanxi, People's Republic of China.
authors.forename: Jun-Rong
authors.initials: JR
authors.lastname: Chen
keywords: ST-segment elevation myocardial infarction; bone marrow mononuclear cells; endothelial progenitor cells; hematopoietic stem cells; mesenchymal stem cells; meta-analysis