title: Diagnosing Pancreatic Tumors Using Contrast-enhanced Harmonic Endoscopic Ultrasonography with Sonazoid.
abstract: Contrast-enhanced harmonic endoscopic ultrasonography (CH-EUS) with contrast agent enabled us to assess the hemodynamics closely, despite limited data in pancreatic tumors. We have initiated a prospective, single arm, and non-randomized study to clarify the accuracy and safety of CH-EUS with Sonazoid and time-intensity curve (TIC) analysis for diagnosing benign or malignant pancreatic tumors. A total of 200 patients will undergo CH-EUS and TIC analysis. Receiver operating characteristic (ROC) analysis will be used to determine the optimal parameter cutoff values for TIC analysis. This will clarify whether CH-EUS and TIC can further improve the diagnosis of pancreatic tumors over conventional EUS.
authors.affiliation: Department of Endoscopy, Okayama University Hospital, Okayama 700-8558, Japan.
authors.forename: Naoki
authors.initials: N
authors.lastname: Yamamoto
authors.forename: Hironari
authors.initials: H
authors.lastname: Kato
authors.forename: Sho
authors.initials: S
authors.lastname: Mizukawa
authors.forename: Shinichiro
authors.initials: S
authors.lastname: Muro
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Akimoto
authors.forename: Daisuke
authors.initials: D
authors.lastname: Uchida
authors.forename: Takeshi
authors.initials: T
authors.lastname: Tomoda
authors.forename: Kazuyuki
authors.initials: K
authors.lastname: Matsumoto
authors.forename: Shigeru
authors.initials: S
authors.lastname: Horiguchi
authors.forename: Koichiro
authors.initials: K
authors.lastname: Tsutsumi
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Okada
mesh_terms: D000328:Adult; D002985:Clinical Protocols; D003287:Contrast Media / Q000494:pharmacology*; D019160:Endosonography / Q000379:methods*; D005290:Ferric Compounds / Q000494:pharmacology*; D006801:Humans; D007501:Iron / Q000494:pharmacology*; D010087:Oxides / Q000494:pharmacology*; D010190:Pancreatic Neoplasms / Q000175:diagnosis*; D055815:Young Adult
chemical_list: D003287:Contrast Media; D005290:Ferric Compounds; D010087:Oxides; C069727:Sonazoid; D007501:Iron