title: Undifferentiated Nasopharyngeal Carcinoma Mimicking Hodgkin Lymphoma With CD30 Expression.
abstract: The presence of CD30-expressing Hodgkin-like cells with a background of inflammation and eosinophils in a young adolescent is usually diagnostic of classical Hodgkin lymphoma. Herein we present the case of a 12-year-old boy presenting with enlarged cervical lymph node characterized by the presence of Hodgkin-like cells expressing CD30 and EBV-LMP1 with a Hodgkin-like background. The Hodgkin-like cells were negative for CD15, CD20, CD45, and Pax-5. The tumor cells, however, expressed several cytokeratins, confirming the diagnosis of an undifferentiated carcinoma nasopharyngeal type. This case highlights the importance of possessing a high index of suspicion when encountering lymph nodes with Hodgkin-like cells and a Hodgkin-like background, even with CD30 expression, as the differential can include undifferentiated carcinoma nasopharyngeal type.
authors.affiliation: American University of Beirut Medical Center, Beirut, Lebanon.
authors.forename: Mark N
authors.initials: MN
authors.lastname: Jabbour
authors.affiliation: American University of Beirut Medical Center, Beirut, Lebanon.
authors.forename: Samer
authors.initials: S
authors.lastname: Nassif
authors.affiliation: American University of Beirut Medical Center, Beirut, Lebanon zc04@aub.edu.lb.
authors.forename: Zaher
authors.initials: Z
authors.lastname: Chakhachiro
mesh_terms: D014408:Biomarkers, Tumor / Q000032:analysis*; D053285:CD30 Ligand / Q000032:analysis / Q000096:biosynthesis; D002277:Carcinoma; D002648:Child; D003937:Diagnosis, Differential; D006689:Hodgkin Disease / Q000175:diagnosis* / Q000473:pathology; D006801:Humans; D016130:Immunophenotyping; D008297:Male; D000077274:Nasopharyngeal Carcinoma; D009303:Nasopharyngeal Neoplasms / Q000175:diagnosis* / Q000473:pathology
chemical_list: D014408:Biomarkers, Tumor; D053285:CD30 Ligand; C505774:TNFSF8 protein, human
keywords: CD30; CKAE1/AE3; EBV-LMP1; classical Hodgkin lymphoma; undifferentiated carcinoma nasopharyngeal type