title: Importance of the PMMA viscoelastic rheology on the reduction of the leakage risk during osteoporotic bone augmentation: A numerical leakage model through a porous media.
abstract: Osteoporotic fractures poses one of the most problematic health issues that affects millions of people by weakening their bones (Osteoporosis). Polymethylmethacrylate (PMMA) cement is usually used to augment the bone and stabilize the fractures. Despite the benefit of using PMMA, it might cause a leakage where the cement undesirably access the surrounding tissues or vessels and lead to a serious complications. Consequently, it is important to study the leakage phenomenon and associated geometric and operation interactions. Although the experimental leakage models have been reported in many studies, a representative numerical leakage model is not exist. Therefore, the objectives of the present paper are to: (a) to develop and validate a representative numerical leakage model; and (b) to investigate numerically and analytically the importance of the rheological parameters (viscosity and relaxation time) on the cement flow to reduce the risk of leakage. ANSYS Polyflow was utilized to implement a 2D numerical leakage model to study the interaction of complex rheological parameters of the cement with the operational and geometrical structure of the representative porous media. In this model, the cement (represented by the upper-convected Maxwell model) flows from the entrance (tip of an 8 gauge cannula) through a porous media with a leakage path (blood vessels) toward the output (Bottom side). The verified and validated numerical leakage model showed the importance of the elastic and viscous part of the cement to control the uniformity of the distributed cement and augmentation pressure, respectively. Moreover, increasing the flow rate can lead to reduce the risk of leakage since the elastic effect will increase. Geometrical parameters of the porous media has a minor effect on changing the elasticity and subsequently on the uniformity of the distributed cement. In conclusion, Cement rheological parameters are found to be the most influential parameters to reduce the risk of leakage by controlling the uniformity of the distributed cement and the augmentation pressure.
authors.affiliation: Mechanical Engineering Department, University of Sherbrooke, Sherbrooke, Québec, Canada J1K 2R1. Electronic address: saenezi@gmail.com.
authors.forename: Salem
authors.initials: S
authors.lastname: Alenezi
authors.affiliation: Mechanical Engineering Department, University of Sherbrooke, Sherbrooke, Québec, Canada J1K 2R1.
authors.forename: Saeed
authors.initials: S
authors.lastname: Jerban
authors.affiliation: Mechanical Engineering Department, University of Sherbrooke, Sherbrooke, Québec, Canada J1K 2R1; Center for Innovations in Technological Ecodesign (CITÉ), University of Sherbrooke, Sherbrooke, Québec, Canada J1K 2R1. Electronic address: Said.Elkoun@usherbrooke.ca.
authors.forename: Saïd
authors.initials: S
authors.lastname: Elkoun
mesh_terms: D001843:Bone Cements / Q000032:analysis*; D006801:Humans; D008962:Models, Theoretical; D010024:Osteoporosis / Q000628:therapy*; D019904:Polymethyl Methacrylate / Q000032:analysis*; D016062:Porosity; D012212:Rheology; D055682:Viscoelastic Substances / Q000032:analysis*
chemical_list: D001843:Bone Cements; D055682:Viscoelastic Substances; D019904:Polymethyl Methacrylate
keywords: Cement elasticity; Flow profile and augmentation pressure; Leakage path; Relaxation time; Viscoelastic fluid