title: Frequency of IgA Nephropathy Presenting at a Tertiary Care Hospital in Pakistan.
abstract: OBJECTIVE
  To determine the frequency of IgAnephropathy presenting at a tertiary care hospital.
  
  
  METHODS
  Across sectional, observational study.
  
  
  METHODS
  Pakistan Institute of Medical Sciences, Islamabad and Shifa International Hospital, Islamabad, Pakistan, from November 2008 to November 2014.
  
  
  METHODS
  This was a retrospective analysis of renal biopsies for the diagnosis of nephropathy during the study period. Biopsies were stained with fluorescence isothyocyanate (FITC) labelled antibodies against IgG, IgA, IgM, C3, C4 and C1q for fluorescent microscopy. For histopathological examination, the specimens were stained with hematoxylin and eosin, Periodic acid Schiff and methanamine silver stains for light microscopy.
  
  
  RESULTS
  Out of total 1,658 renal biopsy cases, 142 (8.6%) were diagnosed as IgA nephropathy on light and immunofluorescence microscopy. Majority of IgAnephropathy patients were young (mean age = 33.2) and presented with proteinuria. The frequency rose from 2% in 2008 to 9.4% in 2014.
  
  
  CONCLUSIONS
  IgAnephropathy was present in younger population and has a rising trend in our population.
authors.affiliation: Department of Nephrology, Pakistan Institute of Medical Sciences, Islamabad.
authors.forename: Shahana
authors.initials: S
authors.lastname: Arshi
authors.affiliation: Department of Histopathology, Shifa International Hospital, Islamabad.
authors.forename: Humaira
authors.initials: H
authors.lastname: Nasir
authors.affiliation: Department of Nephrology, Pakistan Institute of Medical Sciences, Islamabad.
authors.forename: Ghias-Ud-Din
authors.initials: GU
authors.lastname: Butt
authors.affiliation: Department of Histopathology, Shifa International Hospital, Islamabad.
authors.forename: Aasiya
authors.initials: A
authors.lastname: Niazi
authors.affiliation: Department of Histopathology, Shifa International Hospital, Islamabad.
authors.forename: Nadira
authors.initials: N
authors.lastname: Mamoon
authors.affiliation: Medical Student, Shifa College of Medicine, Islamabad.
authors.forename: Sana Roshan
authors.initials: SR
authors.lastname: Qamar
authors.affiliation: Medical Student, Shifa College of Medicine, Islamabad.
authors.forename: Rabia
authors.initials: R
authors.lastname: Mushtaq
mesh_terms: D000328:Adult; D000368:Aged; D001706:Biopsy; D003181:Complement C4 / Q000378:metabolism; D005260:Female; D005455:Fluorescent Antibody Technique; D005922:Glomerulonephritis, IGA / Q000175:diagnosis* / Q000453:epidemiology / Q000503:physiopathology; D006801:Humans; D015994:Incidence; D007668:Kidney / Q000276:immunology / Q000378:metabolism / Q000473:pathology*; D008297:Male; D008856:Microscopy, Fluorescence; D008875:Middle Aged; D010154:Pakistan / Q000453:epidemiology; D011507:Proteinuria / Q000209:etiology*; D012189:Retrospective Studies; D062606:Tertiary Care Centers
chemical_list: D003181:Complement C4