title: Contemporary registries on P2Y12 inhibitors in patients with acute coronary syndromes in Europe: overview and methodological considerations.
abstract: Patient registries that document real-world clinical experience play an important role in cardiology as they complement the data from randomized controlled trials, provide valuable information on drug use and clinical outcomes, and evaluate to what extent guidelines are followed in practice. The Platelet Inhibition Registry in ACS EvalUation Study (PIRAEUS) project is an initiative of registry holders who are managing national or international registries observing patients with acute coronary syndromes (ACS). The aim of PIRAEUS is to systematically compare and combine available information/insights from various European ACS registries with a focus on P2Y12 inhibitors. The present publication introduces the 17 participating registries in a narrative and tabular form, and describes which ACS groups and which dual antiplatelet therapies were investigated. It sets the basis for upcoming publications that will focus on effectiveness and safety of the antiplatelets used.
authors.affiliation: Department of Cardiology, Leiden University Medical Center, Albinusdreef 2, ZA 2333 Leiden, The Netherlands j.w.jukema@lumc.nl.
authors.forename: J Wouter
authors.initials: JW
authors.lastname: Jukema
authors.affiliation: Cardiology Unit, Humanitas Research Hospital, Rozzano (Milano), Italy.
authors.forename: Maddalena
authors.initials: M
authors.lastname: Lettino
authors.affiliation: Cardiocenter, Third Faculty of Medicine, Charles University, Prague, Czech Republic.
authors.forename: Petr
authors.initials: P
authors.lastname: Widimský
authors.affiliation: Department of Cardiology, Hôpital Européen Georges-Pompidou, Paris, France.
authors.forename: Nicolas
authors.initials: N
authors.lastname: Danchin
authors.affiliation: Cardiology Service, Hospital Universitari de Tarragona Joan XXIII, IISPV Tarragona, Tarragona, Spain.
authors.forename: Alfredo
authors.initials: A
authors.lastname: Bardaji
authors.affiliation: Cardiology Service, Hospital Universitari Vall d'Hebron, Barcelona, Spain.
authors.forename: Jose A
authors.initials: JA
authors.lastname: Barrabes
authors.affiliation: Heart Disease Institute, Bellvitge University Hospital IDIBELL, University of Barcelona, Barcelona, Spain.
authors.forename: Angel
authors.initials: A
authors.lastname: Cequier
authors.affiliation: Department of Cardiology, University Hospital Antwerp, Edegem, Belgium.
authors.forename: Marc J
authors.initials: MJ
authors.lastname: Claeys
authors.affiliation: Department of Cardiovascular Sciences, Laboratory of Interventional Cardiology, European Hospital, Rome, Italy.
authors.forename: Leonardo
authors.initials: L
authors.lastname: De Luca
authors.affiliation: University Clinic of Internal Medicine III, Cardiology and Angiology, Medical University of Innsbruck, Innsbruck, Austria.
authors.forename: Jakob
authors.initials: J
authors.lastname: Dörler
authors.affiliation: Department of Cardiology, Skåne University Hospital Lund, Lund, Sweden.
authors.forename: David
authors.initials: D
authors.lastname: Erlinge
authors.affiliation: AMIS-Plus Data Center, University of Zurich, Zurich, Switzerland.
authors.forename: Paul
authors.initials: P
authors.lastname: Erne
authors.affiliation: Pôle de l 'urgence, Service de SAMU du Nord, Centre Hospitalier régional Universitaire de Lille, Lille, France.
authors.forename: Patrick
authors.initials: P
authors.lastname: Goldstein
authors.affiliation: Department of Cardiology, Skåne University Hospital Lund, Lund, Sweden.
authors.forename: Sasha M
authors.initials: SM
authors.lastname: Koul
authors.affiliation: Cardiac Intensive Care Unit, Interventional Cardiology Hopital Cardiologique, Centre Hospitalier Régional et Universitaire de Lille, Lille, France.
authors.forename: Gilles
authors.initials: G
authors.lastname: Lemesle
authors.affiliation: Cardiology Department, Center for Molecular Cardiology, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
authors.forename: Thomas F
authors.initials: TF
authors.lastname: Lüscher
authors.affiliation: Cardiology Department, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
authors.forename: Christian M
authors.initials: CM
authors.lastname: Matter
authors.affiliation: Cardiac Care Unit, Institute of Cardiology, Pitié-Salpêtrière University Hospital, Paris, France.
authors.forename: Gilles
authors.initials: G
authors.lastname: Montalescot
authors.affiliation: Epidemiology, Biostatistics and Prevention Institute, University of Zurich, Zurich, Switzerland.
authors.forename: Dragana
authors.initials: D
authors.lastname: Radovanovic
authors.affiliation: Cardiology Department, Hospital Universitario La Paz, IdiPaz, Madrid, Spain.
authors.forename: Jose
authors.initials: J
authors.lastname: Lopez-Sendón
authors.affiliation: Cardiocenter, Third Faculty of Medicine, Charles University, Prague, Czech Republic.
authors.forename: Petr
authors.initials: P
authors.lastname: Tousek
authors.affiliation: 2nd Department of Medicine with Cardiology and Intensive Care, Hospital Rudolfstiftung, Vienna, Austria.
authors.forename: Franz
authors.initials: F
authors.lastname: Weidinger
authors.affiliation: Swansea University, College of Medicine, Swansea, Wales, UK.
authors.forename: Clive F M
authors.initials: CF
authors.lastname: Weston
authors.affiliation: Department of Cardiology, Freeman Hospital, and Institute of Cellular Medicine, Faculty of Medical Sciences, Newcastle University, Newcastle-upon-Tyne, UK.
authors.forename: Azfar
authors.initials: A
authors.lastname: Zaman
authors.affiliation: Interventional Cardiology, Institut für Herzinfarktforschung Ludwigshafen, Ludwigshafen am Rhein, Germany.
authors.forename: Uwe
authors.initials: U
authors.lastname: Zeymer
mesh_terms: D054058:Acute Coronary Syndrome / Q000188:drug therapy*; D005060:Europe; D006801:Humans; D058921:Purinergic P2Y Receptor Antagonists / Q000627:therapeutic use*; D012042:Registries
chemical_list: D058921:Purinergic P2Y Receptor Antagonists
keywords: Acute coronary syndrome; Antithrombotics; Clopidogrel; Methodology; Non-ST-segment myocardial infarction; Observational; P2Y12 inhibitors; Prasugrel; Real-world evidence; Registries; ST-segment elevation myocardial infarction; Ticagrelor