title: Sustained, Controlled and Stimuli-Responsive Drug Release Systems Based on Nanoporous Anodic Alumina with Layer-by-Layer Polyelectrolyte.
abstract: Controlled drug delivery systems are an encouraging solution to some drug disadvantages such as reduced solubility, deprived biodistribution, tissue damage, fast breakdown of the drug, cytotoxicity, or side effects. Self-ordered nanoporous anodic alumina is an auspicious material for drug delivery due to its biocompatibility, stability, and controllable pore geometry. Its use in drug delivery applications has been explored in several fields, including therapeutic devices for bone and dental tissue engineering, coronary stent implants, and carriers for transplanted cells. In this work, we have created and analyzed a stimuli-responsive drug delivery system based on layer-by-layer pH-responsive polyelectrolyte and nanoporous anodic alumina. The results demonstrate that it is possible to control the drug release using a polyelectrolyte multilayer coating that will act as a gate.
authors.affiliation: Department of Electronic, Electric and Automatics Engineering, Universitat Rovira i Virgili, Avda. Països Catalans 26, 43007, Tarragona, Spain.
authors.forename: Maria
authors.initials: M
authors.lastname: Porta-I-Batalla
authors.affiliation: Department of Electronic, Electric and Automatics Engineering, Universitat Rovira i Virgili, Avda. Països Catalans 26, 43007, Tarragona, Spain.
authors.forename: Chris
authors.initials: C
authors.lastname: Eckstein
authors.affiliation: Department of Electronic, Electric and Automatics Engineering, Universitat Rovira i Virgili, Avda. Països Catalans 26, 43007, Tarragona, Spain.
authors.forename: Elisabet
authors.initials: E
authors.lastname: Xifré-Pérez
authors.affiliation: Department of Electronic, Electric and Automatics Engineering, Universitat Rovira i Virgili, Avda. Països Catalans 26, 43007, Tarragona, Spain.
authors.forename: Pilar
authors.initials: P
authors.lastname: Formentín
authors.affiliation: Department of Electronic, Electric and Automatics Engineering, Universitat Rovira i Virgili, Avda. Països Catalans 26, 43007, Tarragona, Spain.
authors.forename: J
authors.initials: J
authors.lastname: Ferré-Borrull
authors.affiliation: Department of Electronic, Electric and Automatics Engineering, Universitat Rovira i Virgili, Avda. Països Catalans 26, 43007, Tarragona, Spain. lluis.marsal@urv.cat.
authors.forename: Lluis F
authors.identifier: http://orcid.org/0000-0002-5976-1408
authors.initials: LF
authors.lastname: Marsal
keywords: Doxorubicin; Drug delivery; Electrochemical anodization; Nanoporous alumina; Stimuli-responsive release