title: Isolation of a New Homomonoterpene from Madhuca pasquieri and Effect of Isolated Compounds on NO Production.
abstract: A new homomonoterpene, 1,3,3-trimethyl-7-oxabicyclo[3.1.1]hexa-9-en-10-oic acid, named madhusic acid A (1), together with ten known compounds (2-11) were isolated from the methanolic extract of the dried leaves of Madhuca pasquieri (Dubard) H. J. Lam. The structure of the new compound was elucidated on the basis of 1D, 2D NMR (COSY, HMQC, and HMBC) and mass spectral analyses. We examined the effects of the isolated compounds against LPS-induced NO production in macrophage RAW264.7 cells and compound 2 showed effective activity with an IC50 value of 14.5 μM.
authors.forename: Le Son
authors.initials: le S
authors.lastname: Hoang
authors.forename: Manh Hung
authors.initials: MH
authors.lastname: Tran
authors.forename: Van Thu
authors.initials: VT
authors.lastname: Nguyen
authors.forename: Quynh Mai Thi
authors.initials: QM
authors.lastname: Ngo
authors.forename: Joo-Sang
authors.initials: JS
authors.lastname: Lee
authors.forename: Seong-Soo
authors.initials: SS
authors.lastname: Rho
authors.forename: Jeong Ah
authors.initials: JA
authors.lastname: Kim
authors.forename: Jeong-Hyung
authors.initials: JH
authors.lastname: Lee
authors.forename: Mi Hee
authors.initials: MH
authors.lastname: Woo
authors.forename: Byung Sun
authors.initials: BS
authors.lastname: Min
mesh_terms: D000818:Animals; D002460:Cell Line; D008264:Macrophages / Q000187:drug effects* / Q000378:metabolism; D032128:Madhuca / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D015394:Molecular Structure; D039821:Monoterpenes / Q000737:chemistry / Q000494:pharmacology*; D009569:Nitric Oxide / Q000378:metabolism*; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D018515:Plant Leaves / Q000737:chemistry; D000067996:RAW 264.7 Cells
chemical_list: D039821:Monoterpenes; D010936:Plant Extracts; D009569:Nitric Oxide