title: Elevated C-type natriuretic peptide elicits exercise preconditioning-induced cardioprotection against myocardial injury probably via the up-regulation of NPR-B.
abstract: To evaluate exercise preconditioning (EP)-induced cardioprotective effects against exercise-induced acute myocardial injury and investigate the alterations of C-type natriuretic peptide (CNP) and its specific receptor, natriuretic peptide receptor B (NPR-B), during EP-induced cardioprotection. Rats were subjected to treadmill exercise as an EP model (4 periods of 10 min each at 30 m/min with intervening periods of rest lasting 10 min). High-intensity exercise was performed 0.5 and 24 h after the EP. EP attenuated high-intensity exercise-induced myocardial injury in both the early and late phases. After EP and high-intensity exercise, CNP and NPR-B levels increased robustly, but no alterations in the plasma CNP were observed. The enhanced NPR-B, plasma and tissue CNP, and its mRNA levels after high-intensity exercise were significantly elevated by EP. These results suggest that cardiac CNP and NPR-B play an important role in EP-mediated cardioprotection against high-intensity exercise-induced myocardial injury in rats.
authors.affiliation: School of Kinesiology, Shanghai University of Sport, 399 Changhai Road, Shanghai, 200438, China.
authors.forename: Jiao
authors.initials: J
authors.lastname: Lu
authors.affiliation: School of Kinesiology, Shanghai University of Sport, 399 Changhai Road, Shanghai, 200438, China. panshanshan2013@163.com.
authors.forename: Shan-Shan
authors.initials: SS
authors.lastname: Pan
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D008297:Male; D009203:Myocardial Infarction / Q000097:blood / Q000235:genetics / Q000473:pathology / Q000517:prevention & control*; D009206:Myocardium / Q000378:metabolism* / Q000473:pathology; D020098:Natriuretic Peptide, C-Type / Q000097:blood* / Q000235:genetics; D010805:Physical Conditioning, Animal / Q000379:methods*; D005082:Physical Exertion; D017207:Rats, Sprague-Dawley; D017461:Receptors, Atrial Natriuretic Factor / Q000378:metabolism*; D012420:Running; D015398:Signal Transduction; D013997:Time Factors; D015854:Up-Regulation; D000099242:Atrial Natriuretic Factor Receptor B
chemical_list: D020098:Natriuretic Peptide, C-Type; D017461:Receptors, Atrial Natriuretic Factor; D000099242:Atrial Natriuretic Factor Receptor B
keywords: C-type natriuretic peptide; Cardioprotection; Exercise preconditioning; Myocardial injury; Natriuretic peptide receptor B