title: Functional aspects of His bundle physiology and pathophysiology: Clinical implications.
abstract: In this review we present evidence from many experimental studies which challenge the concept of predestination of His bundle fibers. Using both intra- and extracellular His bundle pacing in the context of atrio-ventricular block and the development of bundle branch blocks these experimental studies provide the underlying mechanisms for the recent clinical findings showing the benefits of permanent His bundle pacing.
authors.affiliation: Heart Rhythm Institute, Division of Cardiology, Department of Medicine, Oklahoma University Health Sciences Center, Oklahoma City, OK. Electronic address: benjamin-scherlag@ouhsc.edu.
authors.forename: Benjamin J
authors.initials: BJ
authors.lastname: Scherlag
authors.affiliation: Heart Rhythm Institute, Division of Cardiology, Department of Medicine, Oklahoma University Health Sciences Center, Oklahoma City, OK.
authors.forename: Ralph
authors.initials: R
authors.lastname: Lazzara
mesh_terms: D054537:Atrioventricular Block / Q000503:physiopathology* / Q000517:prevention & control*; D002036:Bundle of His / Q000503:physiopathology*; D002037:Bundle-Branch Block / Q000503:physiopathology* / Q000517:prevention & control*; D002304:Cardiac Pacing, Artificial / Q000379:methods*; D019317:Evidence-Based Medicine; D006801:Humans; D016896:Treatment Outcome
keywords: Bundle branch blocks; Electrocardiogram; His bundle; His bundle pacing