title: Paraprotein-Related Kidney Disease: Glomerular Diseases Associated with Paraproteinemias.
abstract: Paraproteins are monoclonal Igs that accumulate in blood as a result of abnormal excess production. These circulating proteins cause a diversity of kidney disorders that are increasingly being comanaged by nephrologists. In this review, we discuss paraprotein-related diseases that affect the glomerulus. We provide a broad overview of diseases characterized by nonorganized deposits, such as monoclonal Ig deposition disease (MIDD), proliferative GN with monoclonal Ig deposits (PGNMID), and C3 glomerulopathy, as well as those characterized by organized deposits, such as amyloidosis, immunotactoid glomerulopathy, fibrillary GN, and cryoglobulinemic GN, and rarer disorders, such as monoclonal crystalline glomerulopathies, paraprotein-related thrombotic microangiopathies, and membranous-like glomerulopathy with masked IgGκ deposits. This review will provide the nephrologist with an up to date understanding of these entities and highlight the areas of deficit in evidence and future lines of research.
authors.affiliation: Division of Renal Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts.|Adult Survivorship Program, Dana Farber Cancer Institute, Boston, Massachusetts.
authors.forename: Shveta S
authors.initials: SS
authors.lastname: Motwani
authors.affiliation: Department of Pathology, Cleveland Clinic, Cleveland, Ohio.
authors.forename: Leal
authors.initials: L
authors.lastname: Herlitz
authors.affiliation: Division of Nephrology, Department of Medicine, University of Mississippi Medical Center, Jackson, Mississippi; and.
authors.forename: Divya
authors.initials: D
authors.lastname: Monga
authors.affiliation: Division of Kidney Diseases and Hypertension, Hofstra Northwell School of Medicine, Northwell Health, Great Neck, New York.
authors.forename: Kenar D
authors.initials: KD
authors.lastname: Jhaveri
authors.affiliation: Division of Renal Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts.|Adult Survivorship Program, Dana Farber Cancer Institute, Boston, Massachusetts.
authors.forename: Albert Q
authors.initials: AQ
authors.lastname: Lam
mesh_terms: D000686:Amyloidosis / Q000150:complications* / Q000188:drug therapy; D003449:Cryoglobulinemia / Q000150:complications; D005921:Glomerulonephritis / Q000276:immunology / Q000473:pathology; D015432:Glomerulonephritis, Membranoproliferative / Q000276:immunology / Q000473:pathology; D015433:Glomerulonephritis, Membranous / Q000276:immunology; D006801:Humans; D007074:Immunoglobulin G / Q000378:metabolism; D007143:Immunoglobulin Heavy Chains / Q000378:metabolism; D007147:Immunoglobulin Light Chains / Q000378:metabolism; D007674:Kidney Diseases / Q000188:drug therapy / Q000276:immunology* / Q000473:pathology*; D007678:Kidney Glomerulus; D010265:Paraproteinemias / Q000150:complications*; D010266:Paraproteins / Q000378:metabolism*; D057049:Thrombotic Microangiopathies / Q000150:complications
chemical_list: D007074:Immunoglobulin G; D007143:Immunoglobulin Heavy Chains; D007147:Immunoglobulin Light Chains; D010266:Paraproteins
keywords: Amyloidosis; Immunoglobulin G; Kidney Glomerulus; Paraproteinemias; Paraproteins; Thrombotic Microangiopathies; amyloidosis; cancer; cryoglobulinemia; fibrillary glomerulonephritis; glomerular disease; glomerulonephritis; immunotactoid glomerulopathy; light chain deposition disease; multiple myeloma; nephrotic syndrome