title: Disrupted functional connectome in antisocial personality disorder.
abstract: Studies on antisocial personality disorder (ASPD) subjects focus on brain functional alterations in relation to antisocial behaviors. Neuroimaging research has identified a number of focal brain regions with abnormal structures or functions in ASPD. However, little is known about the connections among brain regions in terms of inter-regional whole-brain networks in ASPD patients, as well as possible alterations of brain functional topological organization. In this study, we employ resting-state functional magnetic resonance imaging (R-fMRI) to examine functional connectome of 32 ASPD patients and 35 normal controls by using a variety of network properties, including small-worldness, modularity, and connectivity. The small-world analysis reveals that ASPD patients have increased path length and decreased network efficiency, which implies a reduced ability of global integration of whole-brain functions. Modularity analysis suggests ASPD patients have decreased overall modularity, merged network modules, and reduced intra- and inter-module connectivities related to frontal regions. Also, network-based statistics show that an internal sub-network, composed of 16 nodes and 16 edges, is significantly affected in ASPD patients, where brain regions are mostly located in the fronto-parietal control network. These results suggest that ASPD is associated with both reduced brain integration and segregation in topological organization of functional brain networks, particularly in the fronto-parietal control network. These disruptions may contribute to disturbances in behavior and cognition in patients with ASPD. Our findings may provide insights into a deeper understanding of functional brain networks of ASPD.
authors.affiliation: Department of Radiology, The Third Xiangya Hospital, Central South University, Changsha, Hunan, 410013, China.|Department of Information Science and Engineering, Hunan First Normal University, Changsha, Hunan, 410205, China.|Department of Radiology and BRIC, University of North Carolina at Chapel Hill, 130 Mason Farm Road, Chapel Hill, NC, 27599-7513, USA.|College of Mechatronics and Automation, National University of Defense Technology, Changsha, Hunan, 410073, China.
authors.forename: Weixiong
authors.identifier: 0000-0002-3898-4223
authors.initials: W
authors.lastname: Jiang
authors.affiliation: Department of Radiology and BRIC, University of North Carolina at Chapel Hill, 130 Mason Farm Road, Chapel Hill, NC, 27599-7513, USA.
authors.forename: Feng
authors.initials: F
authors.lastname: Shi
authors.affiliation: Department of Radiology, The Third Xiangya Hospital, Central South University, Changsha, Hunan, 410013, China.
authors.forename: Jian
authors.initials: J
authors.lastname: Liao
authors.affiliation: Department of Radiology, The Third Xiangya Hospital, Central South University, Changsha, Hunan, 410013, China.
authors.forename: Huasheng
authors.initials: H
authors.lastname: Liu
authors.affiliation: Department of Radiology and BRIC, University of North Carolina at Chapel Hill, 130 Mason Farm Road, Chapel Hill, NC, 27599-7513, USA.|Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
authors.forename: Tao
authors.initials: T
authors.lastname: Wang
authors.affiliation: Department of Radiology and BRIC, University of North Carolina at Chapel Hill, 130 Mason Farm Road, Chapel Hill, NC, 27599-7513, USA.
authors.forename: Celina
authors.initials: C
authors.lastname: Shen
authors.affiliation: College of Mechatronics and Automation, National University of Defense Technology, Changsha, Hunan, 410073, China.
authors.forename: Hui
authors.initials: H
authors.lastname: Shen
authors.affiliation: College of Mechatronics and Automation, National University of Defense Technology, Changsha, Hunan, 410073, China.
authors.forename: Dewen
authors.initials: D
authors.lastname: Hu
authors.affiliation: Department of Radiology, The Third Xiangya Hospital, Central South University, Changsha, Hunan, 410013, China. cjr.wangwei@vip.163.com.
authors.forename: Wei
authors.initials: W
authors.lastname: Wang
authors.affiliation: Department of Radiology and BRIC, University of North Carolina at Chapel Hill, 130 Mason Farm Road, Chapel Hill, NC, 27599-7513, USA. dgshen@med.unc.edu.|Department of Brain and Cognitive Engineering, Korea University, Seoul, Republic of Korea. dgshen@med.unc.edu.
authors.forename: Dinggang
authors.initials: D
authors.lastname: Shen
mesh_terms: D000987:Antisocial Personality Disorder / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D001921:Brain / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D063132:Connectome; D057237:Criminals; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D009434:Neural Pathways / Q000000981:diagnostic imaging / Q000503:physiopathology; D012146:Rest; D055815:Young Adult
keywords: Antisocial personality disorder; Brain connectome; Functional connectivity; Modularity; Topological organization