title: Prevalence of Amyloid Positron Emission Tomographic Positivity in Poststroke Mild Cognitive Impairment.
abstract: Mild cognitive impairment (MCI) is common after stroke and associated with poor outcome. However, the mechanisms underlying poststroke MCI (PS-MCI) are insufficiently understood. We performed amyloid-β positron emission tomography (PET) in a prospective cohort of stroke survivors to determine the role of amyloid pathology in PS-MCI.
  
  
  
  We studied 178 consecutive patients enrolled into the prospective DEDEMAS study (Determinants of Dementia After Stroke). Follow-up visits 6 months post stroke included detailed cognitive testing, standardized magnetic resonance imaging, and amyloid-β imaging using flutemetamol ((18)F) PET. MCI was defined by the modified Petersen criteria. Amyloid-positivity was assessed visually and quantitatively. Fifty-six (31%) patients agreed to undergo PET imaging.
  
  
  
  Thirty-eight (68%) patients who consented to PET imaging had PS-MCI. Visual assessment revealed amyloid PET positivity in 2 (5%) of the 38 PS-MCI patients and in 2 (11%) of the 18 cognitively healthy stroke survivors. There was no correlation between flutemetamol ((18)F) standardized uptake value ratios and cognitive scores in the 56 patients. PS-MCI patients had significant cognitive impairments on executive function (P<0.01) and memory tests (P<0.01) when compared with cognitively healthy stroke survivors (P<0.01).
  
  
  
  The prevalence of amyloid-pathology in patients with PS-MCI is not increased when compared with cognitively healthy stroke survivors and to recent estimates for cognitively healthy elderly subjects. Factors other than amyloid-pathology likely contribute to the development of PS-MCI.
  
  
  
  URL: http://www.clinicaltrials.gov. Unique identifier: NCT01334749.
authors.affiliation: From the Institute for Stroke and Dementia Research (F.A.W., C.M., M. Duering, K.B., V.Z., R.M., M. Dichgans), Department of Nuclear Medicine (S.D., M.B., P.B., A.R.), and Institute of Clinical Radiology (B.E.-W.), Klinikum der Universität München, Ludwig-Maximilians-Universität LMU, Munich, Germany; and German Center for Neurodegenerative Diseases (DZNE) (M. Dichgans) and Munich Cluster for Systems Neurology (SyNergy) (P.B., A.R., M. Dichgans), Germany.
authors.forename: Frank Arne
authors.initials: FA
authors.lastname: Wollenweber
authors.affiliation: From the Institute for Stroke and Dementia Research (F.A.W., C.M., M. Duering, K.B., V.Z., R.M., M. Dichgans), Department of Nuclear Medicine (S.D., M.B., P.B., A.R.), and Institute of Clinical Radiology (B.E.-W.), Klinikum der Universität München, Ludwig-Maximilians-Universität LMU, Munich, Germany; and German Center for Neurodegenerative Diseases (DZNE) (M. Dichgans) and Munich Cluster for Systems Neurology (SyNergy) (P.B., A.R., M. Dichgans), Germany.
authors.forename: Sonja
authors.initials: S
authors.lastname: Därr
authors.affiliation: From the Institute for Stroke and Dementia Research (F.A.W., C.M., M. Duering, K.B., V.Z., R.M., M. Dichgans), Department of Nuclear Medicine (S.D., M.B., P.B., A.R.), and Institute of Clinical Radiology (B.E.-W.), Klinikum der Universität München, Ludwig-Maximilians-Universität LMU, Munich, Germany; and German Center for Neurodegenerative Diseases (DZNE) (M. Dichgans) and Munich Cluster for Systems Neurology (SyNergy) (P.B., A.R., M. Dichgans), Germany.
authors.forename: Claudia
authors.initials: C
authors.lastname: Müller
authors.affiliation: From the Institute for Stroke and Dementia Research (F.A.W., C.M., M. Duering, K.B., V.Z., R.M., M. Dichgans), Department of Nuclear Medicine (S.D., M.B., P.B., A.R.), and Institute of Clinical Radiology (B.E.-W.), Klinikum der Universität München, Ludwig-Maximilians-Universität LMU, Munich, Germany; and German Center for Neurodegenerative Diseases (DZNE) (M. Dichgans) and Munich Cluster for Systems Neurology (SyNergy) (P.B., A.R., M. Dichgans), Germany.
authors.forename: Marco
authors.initials: M
authors.lastname: Duering
authors.affiliation: From the Institute for Stroke and Dementia Research (F.A.W., C.M., M. Duering, K.B., V.Z., R.M., M. Dichgans), Department of Nuclear Medicine (S.D., M.B., P.B., A.R.), and Institute of Clinical Radiology (B.E.-W.), Klinikum der Universität München, Ludwig-Maximilians-Universität LMU, Munich, Germany; and German Center for Neurodegenerative Diseases (DZNE) (M. Dichgans) and Munich Cluster for Systems Neurology (SyNergy) (P.B., A.R., M. Dichgans), Germany.
authors.forename: Katharina
authors.initials: K
authors.lastname: Buerger
authors.affiliation: From the Institute for Stroke and Dementia Research (F.A.W., C.M., M. Duering, K.B., V.Z., R.M., M. Dichgans), Department of Nuclear Medicine (S.D., M.B., P.B., A.R.), and Institute of Clinical Radiology (B.E.-W.), Klinikum der Universität München, Ludwig-Maximilians-Universität LMU, Munich, Germany; and German Center for Neurodegenerative Diseases (DZNE) (M. Dichgans) and Munich Cluster for Systems Neurology (SyNergy) (P.B., A.R., M. Dichgans), Germany.
authors.forename: Vera
authors.initials: V
authors.lastname: Zietemann
authors.affiliation: From the Institute for Stroke and Dementia Research (F.A.W., C.M., M. Duering, K.B., V.Z., R.M., M. Dichgans), Department of Nuclear Medicine (S.D., M.B., P.B., A.R.), and Institute of Clinical Radiology (B.E.-W.), Klinikum der Universität München, Ludwig-Maximilians-Universität LMU, Munich, Germany; and German Center for Neurodegenerative Diseases (DZNE) (M. Dichgans) and Munich Cluster for Systems Neurology (SyNergy) (P.B., A.R., M. Dichgans), Germany.
authors.forename: Rainer
authors.initials: R
authors.lastname: Malik
authors.affiliation: From the Institute for Stroke and Dementia Research (F.A.W., C.M., M. Duering, K.B., V.Z., R.M., M. Dichgans), Department of Nuclear Medicine (S.D., M.B., P.B., A.R.), and Institute of Clinical Radiology (B.E.-W.), Klinikum der Universität München, Ludwig-Maximilians-Universität LMU, Munich, Germany; and German Center for Neurodegenerative Diseases (DZNE) (M. Dichgans) and Munich Cluster for Systems Neurology (SyNergy) (P.B., A.R., M. Dichgans), Germany.
authors.forename: Matthias
authors.initials: M
authors.lastname: Brendel
authors.affiliation: From the Institute for Stroke and Dementia Research (F.A.W., C.M., M. Duering, K.B., V.Z., R.M., M. Dichgans), Department of Nuclear Medicine (S.D., M.B., P.B., A.R.), and Institute of Clinical Radiology (B.E.-W.), Klinikum der Universität München, Ludwig-Maximilians-Universität LMU, Munich, Germany; and German Center for Neurodegenerative Diseases (DZNE) (M. Dichgans) and Munich Cluster for Systems Neurology (SyNergy) (P.B., A.R., M. Dichgans), Germany.
authors.forename: Birgit
authors.initials: B
authors.lastname: Ertl-Wagner
authors.affiliation: From the Institute for Stroke and Dementia Research (F.A.W., C.M., M. Duering, K.B., V.Z., R.M., M. Dichgans), Department of Nuclear Medicine (S.D., M.B., P.B., A.R.), and Institute of Clinical Radiology (B.E.-W.), Klinikum der Universität München, Ludwig-Maximilians-Universität LMU, Munich, Germany; and German Center for Neurodegenerative Diseases (DZNE) (M. Dichgans) and Munich Cluster for Systems Neurology (SyNergy) (P.B., A.R., M. Dichgans), Germany.
authors.forename: Peter
authors.initials: P
authors.lastname: Bartenstein
authors.affiliation: From the Institute for Stroke and Dementia Research (F.A.W., C.M., M. Duering, K.B., V.Z., R.M., M. Dichgans), Department of Nuclear Medicine (S.D., M.B., P.B., A.R.), and Institute of Clinical Radiology (B.E.-W.), Klinikum der Universität München, Ludwig-Maximilians-Universität LMU, Munich, Germany; and German Center for Neurodegenerative Diseases (DZNE) (M. Dichgans) and Munich Cluster for Systems Neurology (SyNergy) (P.B., A.R., M. Dichgans), Germany.
authors.forename: Axel
authors.initials: A
authors.lastname: Rominger
authors.affiliation: From the Institute for Stroke and Dementia Research (F.A.W., C.M., M. Duering, K.B., V.Z., R.M., M. Dichgans), Department of Nuclear Medicine (S.D., M.B., P.B., A.R.), and Institute of Clinical Radiology (B.E.-W.), Klinikum der Universität München, Ludwig-Maximilians-Universität LMU, Munich, Germany; and German Center for Neurodegenerative Diseases (DZNE) (M. Dichgans) and Munich Cluster for Systems Neurology (SyNergy) (P.B., A.R., M. Dichgans), Germany. martin.dichgans@med.uni-muenchen.de.
authors.forename: Martin
authors.initials: M
authors.lastname: Dichgans
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000682:Amyloid; D016229:Amyloid beta-Peptides; D001921:Brain / Q000000981:diagnostic imaging*; D060825:Cognitive Dysfunction / Q000000981:diagnostic imaging* / Q000209:etiology; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008568:Memory / Q000502:physiology; D009483:Neuropsychological Tests; D049268:Positron-Emission Tomography; D011446:Prospective Studies; D020521:Stroke / Q000150:complications / Q000000981:diagnostic imaging*
chemical_list: D000682:Amyloid; D016229:Amyloid beta-Peptides
keywords: amyloid; magnetic resonance imaging; mild cognitive impairment; positron emission tomography; stroke