title: MgrB variants in colistin-susceptible and colistin-resistant Klebsiella pneumoniae ST258.
abstract: Resistance determinants of a colistin susceptible and five colistin resistant Klebsiella pneumoniae ST258 from a Hungarian outbreak were investigated. A novel MgrB variant in colistin susceptible strain was found. Elevated phoP and arn gene expressions and wild-type PmrB in all colistin resistant K. pneumoniae were detected. All strains lacked mcr-1.
authors.affiliation: Institute of Medical Microbiology, Semmelweis University, Budapest, Hungary. Electronic address: kocsis.bela@med.semmelweis-univ.hu.
authors.forename: Béla
authors.initials: B
authors.lastname: Kocsis
authors.affiliation: Institute of Medical Microbiology, Semmelweis University, Budapest, Hungary.
authors.forename: Béla
authors.initials: B
authors.lastname: Kádár
authors.affiliation: National Center for Epidemiology, Budapest, Hungary; European Program for Public Health Microbiology Training (EUPHEM), European Centre for Disease Prevention and Control (ECDC), Stockholm, Sweden.
authors.forename: Ákos
authors.initials: Á
authors.lastname: Tóth
authors.affiliation: First Department of Pathology and Experimental Cancer Research, Semmelweis University, Budapest, Hungary.
authors.forename: Alexandra
authors.initials: A
authors.lastname: Fullár
authors.affiliation: Institute of Medical Microbiology, Semmelweis University, Budapest, Hungary.
authors.forename: Dóra
authors.initials: D
authors.lastname: Szabó
mesh_terms: D001426:Bacterial Proteins / Q000235:genetics*; D001483:Base Sequence; D003091:Colistin / Q000494:pharmacology*; D004196:Disease Outbreaks; D024881:Drug Resistance, Bacterial / Q000235:genetics*; D015964:Gene Expression Regulation, Bacterial; D006801:Humans; D006814:Hungary; D007710:Klebsiella Infections / Q000453:epidemiology / Q000382:microbiology; D007711:Klebsiella pneumoniae / Q000235:genetics* / Q000472:pathogenicity; D008565:Membrane Proteins / Q000235:genetics*; D008826:Microbial Sensitivity Tests; D017421:Sequence Analysis
chemical_list: D001426:Bacterial Proteins; D008565:Membrane Proteins; D003091:Colistin
keywords: Colistin resistance; Klebsiella pneumoniae; MgrB; PmrB