title: Traumatic Brain Injury Activation of the Adult Subventricular Zone Neurogenic Niche.
abstract: Traumatic brain injury (TBI) is common in both civilian and military life, placing a large burden on survivors and society. However, with the recognition of neural stem cells in adult mammals, including humans, came the possibility to harness these cells for repair of damaged brain, whereas previously this was thought to be impossible. In this review, we focus on the rodent adult subventricular zone (SVZ), an important neurogenic niche within the mature brain in which neural stem cells continue to reside. We review how the SVZ is perturbed following various animal TBI models with regards to cell proliferation, emigration, survival, and differentiation, and we review specific molecules involved in these processes. Together, this information suggests next steps in attempting to translate knowledge from TBI animal models into human therapies for TBI.
authors.affiliation: Samsung Biomedical Research Institute, Samsung Advanced Institute of Technology, Samsung Electronics Co., Ltd. Seoul, South Korea.
authors.forename: Eun Hyuk
authors.initials: EH
authors.lastname: Chang
authors.affiliation: Department of Physiology, Anatomy and Genetics, University of OxfordOxford, UK; Department of Anatomy, Histology and Embryology, Semmelweis UniversityBudapest, Hungary.
authors.forename: Istvan
authors.initials: I
authors.lastname: Adorjan
authors.affiliation: Department of Biochemistry, Universidade Federal de São Paulo São Paulo, Brazil.
authors.forename: Mayara V
authors.initials: MV
authors.lastname: Mundim
authors.affiliation: Department of Physiology, Anatomy and Genetics, University of Oxford Oxford, UK.
authors.forename: Bin
authors.initials: B
authors.lastname: Sun
authors.affiliation: Department of Pediatrics, Prentice Women's Hospital, Northwestern University Feinberg School of Medicine Chicago, IL, USA.
authors.forename: Maria L V
authors.initials: ML
authors.lastname: Dizon
authors.affiliation: Department of Physiology, Anatomy and Genetics, University of Oxford Oxford, UK.
authors.forename: Francis G
authors.initials: FG
authors.lastname: Szele
keywords: adult neurogenesis; proliferation; regeneration; stem cells; traumatic brain injury (TBI)