title: Effect of Psoriatic Arthritis on Treatment Response in Patients With Moderate to Severe Psoriasis.
abstract: BACKGROUND
  Among patients with moderate-to-severe psoriasis, efficacy, and tolerability of available treatments based on psoriatic arthritis (PsA) history are not well-described.<BR />
  
  
  OBJECTIVE
  We evaluate disease characteristics and treatment response variation in the moderate-to-severe psoriasis population based on PsA history.<BR />
  
  
  METHODS
  Simple-measure for assessing psoriasis activity (S-MAPA) was used to retrospectively analyze treatment responses.<BR />
  
  
  RESULTS
  191 moderate-to-severe psoriatic patients, 58 with and 133 without rheumatologist-diagnosed PsA were analyzed. Regardless of PsA history, S-MAPA improvement was similar with biologic monotherapy (46.2 versus 44.1; <em>P</em>=0.74), traditional systemic monotherapy (62.29 versus 38.12; <em>P</em>=0.22), and combination treatments (64.62 versus 52.71; <em>P</em>=0.40) after 12 weeks. PsA patients on biologic monotherapy experienced a higher infection rate than patients without PsA (0.57% versus 0.19%; <em>P</em>=0.01). PsA patients experienced more adverse events (AEs) associated with traditional systemic monotherapy than biologic monotherapy (3.25 versus 1.04; <em>P</em>=.001).<BR />
  
  
  CONCLUSIONS
  The relatively small PsA cohort was the primary limitation.<BR />
  
  
  CONCLUSIONS
  Patients with moderate-to-severe psoriasis responded similarly to all treatments independent of PsA history. PsA patients received more overall treatments and more biologic monotherapy prescriptions. PsA patients had a greater infection risk on biologic monotherapy compared to those without PsA, and greater adverse events risk on traditional systemic monotherapy compared to biologic monotherapy.<BR /><BR /> <EM>J Drugs Dermatol</EM>. 2016;15(8):917-922.
authors.forename: Jacqueline E
authors.initials: JE
authors.lastname: Greb
authors.forename: Caren
authors.initials: C
authors.lastname: Garber
authors.forename: Alice B
authors.initials: AB
authors.lastname: Gottlieb
mesh_terms: D000328:Adult; D000368:Aged; D015535:Arthritis, Psoriatic / Q000175:diagnosis* / Q000188:drug therapy*; D001688:Biological Products / Q000008:administration & dosage*; D003430:Cross-Sectional Studies; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012720:Severity of Illness Index; D016896:Treatment Outcome
chemical_list: D001688:Biological Products