title: Update on Epidemiology, Diagnosis, and Disease Course of Atopic Dermatitis.
abstract: Studies of the prevalence of atopic dermatitis (AD) have provided insights into associated environmental risk factors, demonstrating the complex interactions between the presence of filaggrin (FLG) gene defects and environment. Among other important findings is that elevated transepidermal water loss (TEWL) in newborns is a strong predictor of AD, regardless of FLG status. Recently recognized predictors of disease course and severity include onset of AD signs and symptoms before 12 months of age and the presence of an FLG mutation and concomitant immunoglobulin E sensitization early in life. Semin Cutan Med Surg 35(supp5):S84-S88.
authors.affiliation: Professor of Dermatology Director of Clinical Studies Oregon Health and Science University Department of Dermatology Portland, Oregon.
authors.forename: Eric L
authors.initials: EL
authors.lastname: Simpson
authors.affiliation: Professor of Dermatology Trinity College Dublin Attending Dermatologist Our Lady's Children's Hospital Crumlin St. James's Hospital Dublin, Ireland.
authors.forename: Alan D
authors.initials: AD
authors.lastname: Irvine
authors.affiliation: Professor of Dermatology and Pediatrics Chief, Pediatric and Adolescent Dermatology University of California San Diego School of Medicine Rady Children's Hospital San Diego, California.
authors.forename: Lawrence F
authors.initials: LF
authors.lastname: Eichenfield
authors.affiliation: Professor of Dermatology and Pediatrics University of California San Diego School of Medicine Fellowship Program Director Pediatric and Adolescent Dermatology Rady Children's Hospital San Diego, California.
authors.forename: Sheila F
authors.initials: SF
authors.lastname: Friedlander
mesh_terms: D002648:Child; D015897:Comorbidity; D003876:Dermatitis, Atopic / Q000175:diagnosis / Q000453:epidemiology / Q000235:genetics / Q000473:pathology; D004777:Environment; D000091344:Filaggrin Proteins; D006801:Humans; D007231:Infant, Newborn; D007381:Intermediate Filament Proteins / Q000235:genetics; D009154:Mutation; D015995:Prevalence; D012307:Risk Factors; D012720:Severity of Illness Index
chemical_list: C000717249:FLG protein, human; D000091344:Filaggrin Proteins; D007381:Intermediate Filament Proteins
keywords: Atopic dermatitis; eczema; filaggrin; food allergy; obesity; peanut
  allergy; skin infection