title: Association of Anti-VEGF Injections with Progression of Geographic Atrophy.
abstract: Age-related macular degeneration (AMD) is one of the leading causes of blindness in developed countries in people over the age of 60 years. One of the forms of advanced AMD is wet AMD. Wet AMD is a result of leakage and bleeding from abnormal neovascularization. The principal treatment for wet AMD is intravitreal anti-VEGF injections. A second form of advanced AMD is geographic atrophy (GA). GA refers to large areas of retinal pigment epithelium loss. In the literature, there is some concern that anti-VEGF injections administered to treat wet AMD may be associated with progression of GA. This review discusses evidence suggesting the association of anti-VEGF injections with progression of GA.
authors.affiliation: Department of Ophthalmology and Visual Sciences, John A. Moran Eye Center, University of Utah, Salt Lake City, UT, USA.
authors.forename: Ryan
authors.initials: R
authors.lastname: Enslow
authors.affiliation: Department of Ophthalmology and Visual Sciences, John A. Moran Eye Center, University of Utah, Salt Lake City, UT, USA.
authors.forename: Sai
authors.initials: S
authors.lastname: Bhuvanagiri
authors.affiliation: Department of Ophthalmology and Visual Sciences, John A. Moran Eye Center, University of Utah, Salt Lake City, UT, USA.
authors.forename: Sravanthi
authors.initials: S
authors.lastname: Vegunta
authors.affiliation: Department of Ophthalmology and Visual Sciences, John A. Moran Eye Center, University of Utah, Salt Lake City, UT, USA.
authors.forename: Benjamin
authors.initials: B
authors.lastname: Cutler
authors.affiliation: Department of Ophthalmology and Visual Sciences, John A. Moran Eye Center, University of Utah, Salt Lake City, UT, USA.
authors.forename: Michael
authors.initials: M
authors.lastname: Neff
authors.affiliation: Department of Ophthalmology and Visual Sciences, John A. Moran Eye Center, University of Utah, Salt Lake City, UT, USA.
authors.forename: Brian
authors.initials: B
authors.lastname: Stagg
keywords: anti-VEGF treatment; geographic atrophy; macular degeneration; neovascularization