title: Electrophysiological responses from intrinsically photosensitive retinal ganglion cells are diminished in glaucoma patients.
abstract: OBJECTIVE
  To record electroretinograms (ERGs) from intrinsically photosensitive retinal ganglion cells (ipRGCs) of glaucoma patients.
  
  
  METHODS
  ERGs were recorded in 10 normal subjects and 15 patients with glaucoma. The ERG illumination system was built to achieve receptor-silent substitution, and comprised an optical diffuser and four-in-one light-emitting diodes.
  
  
  RESULTS
  The ERG recordings of ipRGC from normal subjects showed an "on" response and an "off" response. The mean (±SD) implicit time for the on and off responses in normal subjects was 103.0±24.9 and 337.9±45.8ms, respectively, with corresponding amplitudes of 7.7±2.8 and 7.3±3.4μV, respectively. In glaucoma patients, the implicit time of the on and off responses was 135.0±28.9 and 368.2±17.3ms, respectively. The corresponding amplitudes of the on and off responses in these patients were 0.47±0.18 and 0.66±0.32μV, respectively.
  
  
  CONCLUSIONS
  The results demonstrate successful ERG recording of ipRGCs from advanced glaucoma patients, with marked reductions in amplitude, although not implicit time, compared with normal subjects.
authors.affiliation: Department of Ophthalmology, Mie University Graduate School of Medicine, 2-174, Edobashi, Tsu, Mie 514-8507, Japan; Ophthalmology Clinic, Matsusaka Central General Hospital, 102 Kobo, Kawai-machi, Matsusaka, Mie 515-8566, Japan. Electronic address: manakuze@yahoo.co.jp.
authors.forename: Manami
authors.initials: M
authors.lastname: Kuze
authors.affiliation: Department of Living Environmental Science, Fukuoka Women's University, 1-1-1 Kasumigaoka, Higashi-ku, Fukuoka 813-8529, Japan.
authors.forename: Takeshi
authors.initials: T
authors.lastname: Morita
authors.affiliation: Department of Living Environmental Science, Fukuoka Women's University, 1-1-1 Kasumigaoka, Higashi-ku, Fukuoka 813-8529, Japan.
authors.forename: Yumi
authors.initials: Y
authors.lastname: Fukuda
authors.affiliation: Department of Ophthalmology, Mie University Graduate School of Medicine, 2-174, Edobashi, Tsu, Mie 514-8507, Japan.
authors.forename: Mineo
authors.initials: M
authors.lastname: Kondo
authors.affiliation: Department of Ophthalmology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku, 160-8582 Tokyo, Japan.
authors.forename: Kazuo
authors.initials: K
authors.lastname: Tsubota
authors.affiliation: Department of Ophthalmology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku, 160-8582 Tokyo, Japan.
authors.forename: Masahiko
authors.initials: M
authors.lastname: Ayaki
mesh_terms: D000328:Adult; D004596:Electroretinography; D005260:Female; D005902:Glaucoma, Open-Angle / Q000503:physiopathology*; D064368:Healthy Volunteers; D006801:Humans; D008297:Male; D008875:Middle Aged; D010775:Photic Stimulation / Q000379:methods; D012165:Retinal Ganglion Cells / Q000473:pathology*; D041623:Tomography, Optical Coherence; D058609:Visual Field Tests
keywords: Células ganglionares de la retina intrínsecamente fotosensibles (ipRGCs); Electroretinogram (ERG); Electrorretinograma (ERG); Glaucoma; Intrinsically photosensitive retinal ganglion cells (ipRGCs)