title: A Phase II Clinical Trial Evaluating the Preventive Effectiveness of Lactobacillus Vaginal Suppositories in Patients with Recurrent Cystitis.
abstract: Urinary tract infections (UTIs) are the most common bacterial infections in women, and many patients experience frequent recurrence. The aim of this report is to introduce an on-going prospective phase II clinical trial performed to evaluate the preventive effectiveness of Lactobacillus vaginal suppositories for prevention of recurrent cystitis. Patients enrolled in this study are administered vaginal suppositories containing the GAI 98322 strain of Lactobacillus crispatus every 2 days or 3 times a week for one year. The primary endpoint is recurrence of cystitis and the secondary endpoints are adverse events. Recruitment began in December 2013 and target sample size is 20 participants.
authors.affiliation: Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700-8558, Japan.gmd17055@s.okadai.jp.
authors.forename: Koichiro
authors.initials: K
authors.lastname: Wada
authors.forename: Shinya
authors.initials: S
authors.lastname: Uehara
authors.forename: Ayano
authors.initials: A
authors.lastname: Ishii
authors.forename: Takuya
authors.initials: T
authors.lastname: Sadahira
authors.forename: Masumi
authors.initials: M
authors.lastname: Yamamoto
authors.forename: Ritsuko
authors.initials: R
authors.lastname: Mitsuhata
authors.forename: Atsushi
authors.initials: A
authors.lastname: Takamoto
authors.forename: Motoo
authors.initials: M
authors.lastname: Araki
authors.forename: Yasuyuki
authors.initials: Y
authors.lastname: Kobayashi
authors.forename: Masami
authors.initials: M
authors.lastname: Watanabe
authors.forename: Toyohiko
authors.initials: T
authors.lastname: Watanabe
authors.forename: Katsuyuki
authors.initials: K
authors.lastname: Hotta
authors.forename: Yasutomo
authors.initials: Y
authors.lastname: Nasu
mesh_terms: D001424:Bacterial Infections / Q000517:prevention & control*; D002985:Clinical Protocols; D017322:Clinical Trials, Phase II as Topic; D003556:Cystitis / Q000517:prevention & control*; D005260:Female; D006801:Humans; D007778:Lactobacillus / Q000145:classification / Q000502:physiology*; D012107:Research Design; D013488:Suppositories
chemical_list: D013488:Suppositories