title: Triglyceride Treatment in the Age of Cholesterol Reduction.
abstract: Cholesterol reduction has markedly reduced major cardiovascular disease (CVD) events and shown regression of atherosclerosis in some studies. However, CVD has for decades also been associated with increased levels of circulating triglyceride (TG)-rich lipoproteins. Whether this is due to a direct toxic effect of these lipoproteins on arteries or whether this is merely an association is unresolved. More recent genetic analyses have linked genes that modulate TG metabolism with CVD. Moreover, analyses of subgroups of hypertriglyceridemic (HTG) subjects in clinical trials using fibric acid drugs have been interpreted as evidence that TG reduction reduces CVD events. This review will focus on how HTG might cause CVD, whether TG reduction makes a difference, what pathophysiological defects cause HTG, and what options are available for treatment.
authors.affiliation: Division of Endocrinology, Diabetes and Metabolism, New York University School of Medicine, New York, NY.
authors.forename: Nidhi
authors.initials: N
authors.lastname: Agrawal
authors.affiliation: Division of Endocrinology, Diabetes and Metabolism, New York University School of Medicine, New York, NY.
authors.forename: Patricia
authors.initials: P
authors.lastname: Freitas Corradi
authors.affiliation: Division of Endocrinology, Diabetes and Metabolism, New York University School of Medicine, New York, NY.
authors.forename: Namrata
authors.initials: N
authors.lastname: Gumaste
authors.affiliation: Division of Endocrinology, Diabetes and Metabolism, New York University School of Medicine, New York, NY. Electronic address: Ira.Goldberg@NYUMC.org.
authors.forename: Ira J
authors.initials: IJ
authors.lastname: Goldberg
mesh_terms: D002318:Cardiovascular Diseases / Q000209:etiology / Q000378:metabolism / Q000517:prevention & control*; D019468:Disease Management; D006801:Humans; D015228:Hypertriglyceridemia / Q000150:complications / Q000188:drug therapy / Q000378:metabolism; D000960:Hypolipidemic Agents / Q000494:pharmacology*; D014280:Triglycerides / Q000378:metabolism*
chemical_list: D000960:Hypolipidemic Agents; D014280:Triglycerides
keywords: Cardiovascular disease; Hyperlipidemia; Hypertriglyceridemia; Triglyceride