title: Synchrony of auditory brain responses predicts behavioral ability to keep still in children with autism spectrum disorder: Auditory-evoked response in children with autism spectrum disorder.
abstract: The auditory-evoked P1m, recorded by magnetoencephalography, reflects a central auditory processing ability in human children. One recent study revealed that asynchrony of P1m between the right and left hemispheres reflected a central auditory processing disorder (i.e., attention deficit hyperactivity disorder, ADHD) in children. However, to date, the relationship between auditory P1m right-left hemispheric synchronization and the comorbidity of hyperactivity in children with autism spectrum disorder (ASD) is unknown. In this study, based on a previous report of an asynchrony of P1m in children with ADHD, to clarify whether the P1m right-left hemispheric synchronization is related to the symptom of hyperactivity in children with ASD, we investigated the relationship between voice-evoked P1m right-left hemispheric synchronization and hyperactivity in children with ASD. In addition to synchronization, we investigated the right-left hemispheric lateralization. Our findings failed to demonstrate significant differences in these values between ASD children with and without the symptom of hyperactivity, which was evaluated using the Autism Diagnostic Observational Schedule, Generic (ADOS-G) subscale. However, there was a significant correlation between the degrees of hemispheric synchronization and the ability to keep still during 12-minute MEG recording periods. Our results also suggested that asynchrony in the bilateral brain auditory processing system is associated with ADHD-like symptoms in children with ASD.
authors.affiliation: Research Center for Child Mental Development, Kanazawa University, Kanazawa 920-8640, Japan.
authors.forename: Yuko
authors.initials: Y
authors.lastname: Yoshimura
authors.affiliation: Research Center for Child Mental Development, Kanazawa University, Kanazawa 920-8640, Japan.
authors.forename: Mitsuru
authors.initials: M
authors.lastname: Kikuchi
authors.affiliation: Research Center for Child Mental Development, Kanazawa University, Kanazawa 920-8640, Japan.
authors.forename: Hirotoshi
authors.initials: H
authors.lastname: Hiraishi
authors.affiliation: Research Center for Child Mental Development, Kanazawa University, Kanazawa 920-8640, Japan.
authors.forename: Chiaki
authors.initials: C
authors.lastname: Hasegawa
authors.affiliation: Research Center for Child Mental Development, Kanazawa University, Kanazawa 920-8640, Japan.
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Takahashi
authors.affiliation: International Education Center, Kyushu University, Fukuoka 819-0395, Japan.
authors.forename: Gerard B
authors.initials: GB
authors.lastname: Remijn
authors.affiliation: Research Center for Child Mental Development, Kanazawa University, Kanazawa 920-8640, Japan.
authors.forename: Manabu
authors.initials: M
authors.lastname: Oi
authors.affiliation: Research Center for Child Mental Development, Kanazawa University, Kanazawa 920-8640, Japan.
authors.forename: Toshio
authors.initials: T
authors.lastname: Munesue
authors.affiliation: Research Center for Child Mental Development, Kanazawa University, Kanazawa 920-8640, Japan.
authors.forename: Haruhiro
authors.initials: H
authors.lastname: Higashida
authors.affiliation: Research Center for Child Mental Development, Kanazawa University, Kanazawa 920-8640, Japan.
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Minabe
mesh_terms: D000161:Acoustic Stimulation; D000704:Analysis of Variance; D001289:Attention Deficit Disorder with Hyperactivity / Q000175:diagnosis* / Q000209:etiology*; D000067877:Autism Spectrum Disorder / Q000150:complications*; D002648:Child; D002675:Child, Preschool; D004569:Electroencephalography; D058407:Electroencephalography Phase Synchronization / Q000502:physiology*; D005072:Evoked Potentials, Auditory / Q000502:physiology*; D005260:Female; D007839:Functional Laterality / Q000502:physiology; D006801:Humans; D015225:Magnetoencephalography; D008297:Male; D011930:Reaction Time / Q000502:physiology; D013223:Statistics as Topic
keywords: ADHD, attention deficit hyperactivity disorder; AEF, auditory-evoked field; ASD, autism spectrum disorder; Autism spectrum disorder (ASD); ECD, equivalent current dipole; Hyperactivity; ISI, inter-stimulus interval; MEG, magnetoencephalography; Magnetoencephalography (MEG); P1m; TD, typically developing; Young children