title: The Absorb bioresorbable vascular scaffold for the treatment of coronary artery disease.
abstract: Every decade the field of interventional cardiology is revolutionized by new technology. The fully bioresorbable everolimus-eluting scaffold (ABSORB BVS) technology would preserve the benefits of metallic stents by sealing balloon-induced dissections, avoiding elastic recoil and vessel occlusion. The polymeric scaffold would be resorbed to restore the natural integrity of the vessel, superseding the consequence of the permanent presence of a foreign body in the coronary artery.
  
  
  
  This technology evaluation focuses on the clinical evidence for the use of bioresorbable everolimus-eluting scaffold for the treatment of coronary artery disease.
  
  
  
  The current generation of the bioresorbable scaffold has structural and mechanical limitations that might preclude the widespread use in clinical practice. The strut thickness (150 µm) limits deliverability and creates laminar flow disruptions that might be the nidus of an increased rate of scaffold thrombosis. In the next generation of bioresorbable scaffolds, the resorption process should be faster and in particular, strut thickness must be reduced. This will probably represent a significant step forward in an attempt to increase the efficacy and safety profile of the device and achieve a similar performance with the current generation drug-eluting stent even in complex scenarios.
authors.affiliation: a Department of Cardiology, Academic Medical Center , University of Amsterdam , Amsterdam , The Netherlands.
authors.forename: Carlos
authors.initials: C
authors.lastname: Collet
authors.affiliation: a Department of Cardiology, Academic Medical Center , University of Amsterdam , Amsterdam , The Netherlands.
authors.forename: Robbert J
authors.initials: RJ
authors.lastname: de Winter
authors.affiliation: b Department of Interventional Cardiology , Erasmus Medical Center , Rotterdam , The Netherlands.
authors.forename: Yoshinobu
authors.initials: Y
authors.lastname: Onuma
authors.affiliation: c Faculty of Medicine , Imperial College London , London , UK.
authors.forename: Patrick W
authors.initials: PW
authors.lastname: Serruys
mesh_terms: D020341:Absorbable Implants; D003324:Coronary Artery Disease / Q000628:therapy*; D054855:Drug-Eluting Stents; D000068338:Everolimus / Q000008:administration & dosage*; D006801:Humans; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D000068338:Everolimus
keywords: Absorb; Biodegradable scaffold; coronary artery disease