title: Proteomic profiling of human plasma for cancer biomarker discovery.
abstract: Over the past decades, substantial advances have been made in both the early diagnosis and accurate prognosis of many cancers because of the impressive development of novel proteomic strategies. However, it remains difficult to standardize proteomic approaches. In addition, the heterogeneity of proteins in distinct tissues results in incomplete population of the whole proteome, which inevitably limits its clinical practice. As one of the most complex proteomes in the human body, the plasma proteome contains secreted proteins originating from multiple organs and tissues, making it a favorable matrix for comprehensive biomarker discovery. Here, we will discuss the roles of plasma proteome profiling in cancer biomarker discovery and validation, and highlight both the inherent advantages and disadvantages. Although several hurdles lay ahead, further advances in this technology will greatly increase our understanding of cancer biology, reveal new biomarkers and biomarker panels, and open a new avenue for more efficient early diagnosis and surveillance of cancer, leading toward personalized medicine.
authors.affiliation: Key Laboratory of Tropical Diseases and Translational Medicine of Ministry of Education & Department of Neurology, The Affiliated Hospital of Hainan Medical College, Haikou, P. R. China.|Criminal police detachment of Guang'an City Public Security Bureau, P. R. China.
authors.forename: Zhao
authors.initials: Z
authors.lastname: Huang
authors.affiliation: Criminal police detachment of Guang'an City Public Security Bureau, P. R. China.
authors.forename: Linguang
authors.initials: L
authors.lastname: Ma
authors.affiliation: State Key Laboratory for Biotherapy and Cancer Center, West China Hospital, Sichuan University, and Collaborative Innovation Center of Biotherapy, Chengdu, P. R. China.
authors.forename: Canhua
authors.initials: C
authors.lastname: Huang
authors.affiliation: Key Laboratory of Tropical Diseases and Translational Medicine of Ministry of Education & Department of Neurology, The Affiliated Hospital of Hainan Medical College, Haikou, P. R. China.
authors.forename: Qifu
authors.initials: Q
authors.lastname: Li
authors.affiliation: Department of Biochemistry and Molecular Biology, Monash University, Clayton, Australia.
authors.forename: Edouard C
authors.initials: EC
authors.lastname: Nice
mesh_terms: D014408:Biomarkers, Tumor / Q000097:blood*; D001798:Blood Proteins / Q000378:metabolism*; D006801:Humans; D009369:Neoplasms / Q000097:blood*; D020543:Proteome / Q000378:metabolism; D040901:Proteomics / Q000379:methods*
chemical_list: D014408:Biomarkers, Tumor; D001798:Blood Proteins; D020543:Proteome
keywords: Biomarkers; Biomedicine; Cancer; Personalized medicine; Plasma; Protein purification