title: A novel temperature-responsive micelle for enhancing combination therapy.
abstract: A novel thermosensitive polymer p(N-isopropylacrylamide-co-poly[ethylene glycol] methyl ether acrylate)-block-poly(epsilon-caprolactone), p(NIPAAM-co-PEGMEA)-b-PCL, was synthesized and developed as nanomicelles. The hydrophobic heat shock protein 90 inhibitor 17-allylamino-17-demethoxygeldanamycin and the photosensitizer cyanine dye infrared-780 were loaded into the core of the micelles to achieve both chemotherapy and photothermal therapy simultaneously at the tumor site. The release of the drug could be controlled by varying the temperature due to the thermosensitive nature of the micelles. The micelles were less than 200 nm in size, and the drug encapsulation efficiency was >50%. The critical micelle concentrations were small enough to allow micelle stability upon dilution. Data from cell viability and animal experiments indicate that this combination treatment using photothermal therapy with chemotherapy had synergistic effects while decreasing side effects.
authors.affiliation: Isotope application Division, Institute of Nuclear energy research, Taoyuan.
authors.forename: Cheng-Liang
authors.initials: CL
authors.lastname: Peng
authors.affiliation: Institute of Biomedical Engineering, College of Medicine and College of Engineering, National Taiwan University, Taipei; Department of Oncology, National Taiwan University Hospital and College of Medicine, Taipei, Taiwan.
authors.forename: Yuan-I
authors.initials: YI
authors.lastname: Chen
authors.affiliation: Institute of Biomedical Engineering, College of Medicine and College of Engineering, National Taiwan University, Taipei.
authors.forename: Hung-Jen
authors.initials: HJ
authors.lastname: Liu
authors.affiliation: Institute of Biomedical Engineering, College of Medicine and College of Engineering, National Taiwan University, Taipei.
authors.forename: Pei-Chi
authors.initials: PC
authors.lastname: Lee
authors.affiliation: Isotope application Division, Institute of Nuclear energy research, Taoyuan.
authors.forename: Tsai-Yueh
authors.initials: TY
authors.lastname: Luo
authors.affiliation: Institute of Biomedical Engineering, College of Medicine and College of Engineering, National Taiwan University, Taipei; Department of Oncology, National Taiwan University Hospital and College of Medicine, Taipei, Taiwan.
authors.forename: Ming-Jium
authors.initials: MJ
authors.lastname: Shieh
mesh_terms: D000180:Acrylic Resins / Q000138:chemical synthesis / Q000737:chemistry; D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology; D016227:Benzoquinones / Q000494:pharmacology; D004337:Drug Carriers / Q000737:chemistry; D065546:Drug Liberation; D004357:Drug Synergism; D004359:Drug Therapy, Combination; D045325:HCT116 Cells; D006801:Humans; D007211:Indoles / Q000494:pharmacology; D007259:Infrared Rays; D047029:Lactams, Macrocyclic / Q000494:pharmacology; D008819:Mice, Nude; D016513:Mice, SCID; D008823:Micelles; D008970:Molecular Weight; D011091:Polyesters / Q000138:chemical synthesis / Q000737:chemistry; D013696:Temperature
chemical_list: C548458:2-(2-(2-chloro-3-((1,3-dihydro-3,3-dimethyl-1-propyl-2H-indol-2-ylidene)ethylidene)-1-cyclohexen-1-yl)ethenyl)-3,3-dimethyl-1-propylindolium; D000180:Acrylic Resins; D000970:Antineoplastic Agents; D016227:Benzoquinones; D004337:Drug Carriers; D007211:Indoles; D047029:Lactams, Macrocyclic; D008823:Micelles; D011091:Polyesters; C016240:polycaprolactone; C052970:poly-N-isopropylacrylamide; C112765:tanespimycin
keywords: chemotherapy; control release; nanocarrier; photothermal therapy; synergistic effect; thermosensitive