title: Diet and Gut Microbial Function in Metabolic and Cardiovascular Disease Risk.
abstract: Over the past decade, the gut microbiome has emerged as a novel and largely unexplored source of variability for metabolic and cardiovascular disease risk, including diabetes. Animal and human studies support several possible pathways through which the gut microbiome may impact health, including the production of health-related metabolites from dietary sources. Diet is considered important to shaping the gut microbiota; in addition, gut microbiota influence the metabolism of many dietary components. In the present paper, we address the distinction between compositional and functional analysis of the gut microbiota. We focus on literature that highlights the value of moving beyond surveys of microbial composition to measuring gut microbial functioning to delineate mechanisms related to the interplay between diet and gut microbiota in cardiometabolic health.
authors.affiliation: Department of Nutrition, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, 2003 Michael Hooker Research Center, CB no. 7461, Chapel Hill, NC, 27599, USA. ktmeyer@unc.edu.|Nutrition Research Institute, University of North Carolina at Chapel Hill, 500 Laureate Way, Kannapolis, NC, 28081, USA. ktmeyer@unc.edu.
authors.forename: Katie A
authors.initials: KA
authors.lastname: Meyer
authors.affiliation: Department of Nutrition, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, 2003 Michael Hooker Research Center, CB no. 7461, Chapel Hill, NC, 27599, USA.|Nutrition Research Institute, University of North Carolina at Chapel Hill, 500 Laureate Way, Kannapolis, NC, 28081, USA.|Department of Genetics, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
authors.forename: Brian J
authors.initials: BJ
authors.lastname: Bennett
mesh_terms: D000818:Animals; D002318:Cardiovascular Diseases / Q000209:etiology*; D003920:Diabetes Mellitus / Q000209:etiology*; D004032:Diet; D000069196:Gastrointestinal Microbiome / Q000502:physiology*; D006801:Humans
keywords: Cardiovascular disease; Diabetes; Gut microbiota; Metabolites; Nutrition