title: Celecoxib Adjunctive Treatment to Antipsychotics in Schizophrenia: A Review of Randomized Clinical Add-On Trials.
abstract: Schizophrenia is a severe, chronic and debilitating mental disorder. Past literature has reported various hypotheses about the psychopathology of schizophrenia. Recently, a growing literature has been trying to explain the role of inflammation in the etiopathogenesis of schizophrenia. In the past, numerous immune modulation and anti-inflammatory treatment options have been proposed for schizophrenia, but sometimes the results were inconsistent. Electronic search was carried out in November 2015. PubMed and Scopus databases have been used to find studies to introduce in this review. Only randomized-placebo-controlled add-on trials were taken into account. In this way, six articles were obtained for the discussion. Celecoxib showed beneficial effects mostly in early stages of schizophrenia. In chronic schizophrenia, the data are controversial, possibly in part for methodological reasons.
authors.affiliation: Department of Neurosciences Clinical Imaging, Chair of Psychiatry, "G. d'Annunzio" University, 65100 Chieti, Italy; Polyedra Research Group, 64100 Teramo, Italy.
authors.forename: Stefano
authors.identifier: 0000-0002-1771-6940
authors.initials: S
authors.lastname: Marini
authors.affiliation: Polyedra Research Group, 64100 Teramo, Italy; NHS, Department of Mental Health, Psychiatric Service of Diagnosis and Treatment, Hospital "G. Mazzini", ASL 4, 64100 Teramo, Italy.
authors.forename: Domenico
authors.initials: D
authors.lastname: De Berardis
authors.affiliation: Department of Neurosciences Clinical Imaging, Chair of Psychiatry, "G. d'Annunzio" University, 65100 Chieti, Italy; Polyedra Research Group, 64100 Teramo, Italy.
authors.forename: Federica
authors.initials: F
authors.lastname: Vellante
authors.affiliation: Department of Neurosciences Clinical Imaging, Chair of Psychiatry, "G. d'Annunzio" University, 65100 Chieti, Italy.
authors.forename: Rita
authors.initials: R
authors.lastname: Santacroce
authors.affiliation: Polyedra Research Group, 64100 Teramo, Italy; Villa S. Giuseppe Hospital, Hermanas Hospitalarias, 63100 Ascoli Piceno, Italy; School of Life and Medical Sciences, University of Hertfordshire, Hatfield AL10 9AB, UK.
authors.forename: Laura
authors.initials: L
authors.lastname: Orsolini
authors.affiliation: Polyedra Research Group, 64100 Teramo, Italy; Villa S. Giuseppe Hospital, Hermanas Hospitalarias, 63100 Ascoli Piceno, Italy.
authors.forename: Alessandro
authors.initials: A
authors.lastname: Valchera
authors.affiliation: Polyedra Research Group, 64100 Teramo, Italy.
authors.forename: Gabriella
authors.initials: G
authors.lastname: Girinelli
authors.affiliation: Department of Neurosciences Clinical Imaging, Chair of Psychiatry, "G. d'Annunzio" University, 65100 Chieti, Italy.
authors.forename: Alessandro
authors.initials: A
authors.lastname: Carano
authors.affiliation: New York State Psychiatric Institute, Columbia University, New York, NY 10027, USA.
authors.forename: Michele
authors.initials: M
authors.lastname: Fornaro
authors.affiliation: Department of Neurosciences Clinical Imaging, Chair of Psychiatry, "G. d'Annunzio" University, 65100 Chieti, Italy.
authors.forename: Francesco
authors.initials: F
authors.lastname: Gambi
authors.affiliation: Department of Neurosciences Clinical Imaging, Chair of Psychiatry, "G. d'Annunzio" University, 65100 Chieti, Italy.
authors.forename: Giovanni
authors.initials: G
authors.lastname: Martinotti
authors.affiliation: Department of Neurosciences Clinical Imaging, Chair of Psychiatry, "G. d'Annunzio" University, 65100 Chieti, Italy.
authors.forename: Massimo
authors.initials: M
authors.lastname: Di Giannantonio
mesh_terms: D014150:Antipsychotic Agents / Q000627:therapeutic use*; D000068579:Celecoxib / Q000627:therapeutic use*; D006801:Humans; D016032:Randomized Controlled Trials as Topic; D012559:Schizophrenia / Q000188:drug therapy*
chemical_list: D014150:Antipsychotic Agents; D000068579:Celecoxib