title: The Role of NF-kB Inhibitors in Cell Response to Radiation.
abstract: It is well documented that ionizing radiation (IR) activates the transcription factor (NF-κB) which is a trigger for resistance cancer cells to treatment. It is involved in activation of pro-survival signaling pathways and resulting in cancer development and progression. In unstimulated condition, NF-κB is sequestered in cytoplasm but after the cell exposure to IR, proteasomal degradation of IκB flowing phosphorylation via IKK, leads to aberrantly NF-κB activation and nuclear translocation. Therefore, interruption in IκB degradation, proteasome action, IKK phosphorylation and NF-κB nuclear translocation provide robust strategies for inhibiting adverse effect of IR induced NF-κB. In spite of uncompleted elucidation of NF-κB molecular mechanisms, different NF-κB inhibitors have been used in order to inhibiting the IR induced NF-κB. The aim of this review is to highlight the role of IR induced-NF-κB inhibitors such as MG132, bortezomib, curcumin, DHMEQ, naringin, sorafenib, genistein and parthenolide in suppression of IR induced NF-κB adverse effects. Moreover, their chemical, structural characteristics and molecular mechanisms will be discussed.
authors.forename: Sajjad Molavi
authors.initials: SM
authors.lastname: Pordanjani
authors.affiliation: Department of Radiopharmacy, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran. sjhosseinim@mazums.ac.ir.
authors.forename: Seyed Jalal
authors.initials: SJ
authors.lastname: Hosseinimehr
mesh_terms: D017209:Apoptosis / Q000187:drug effects / Q000528:radiation effects*; D000069286:Bortezomib / Q000737:chemistry / Q000494:pharmacology; D045744:Cell Line, Tumor; D004249:DNA Damage / Q000187:drug effects / Q000528:radiation effects; D019833:Genistein / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D051550:I-kappa B Kinase / Q000378:metabolism; D007976:Leupeptins / Q000737:chemistry / Q000494:pharmacology; D016328:NF-kappa B / Q000037:antagonists & inhibitors* / Q000378:metabolism; D011839:Radiation, Ionizing
chemical_list: D007976:Leupeptins; D016328:NF-kappa B; D000069286:Bortezomib; D019833:Genistein; D051550:I-kappa B Kinase; C072553:benzyloxycarbonylleucyl-leucyl-leucine aldehyde