title: Adipokines in psoriasis: An important link between skin inflammation and metabolic alterations.
abstract: Psoriasis is a chronic inflammatory skin disease most common in Europe, North America, and Australia. The etiology and pathomechanisms underlying the evolution and persistence of the skin alterations are increasingly being understood and have led to the development of effective anti-psoriatic therapies. Apart from the skin manifestations, psoriasis is associated with the metabolic syndrome (MetS), known to increase the risk of type 2 diabetes mellitus and cardiovascular disorders. Research of the last years demonstrated a dysregulated adipokine balance as an important link between inflammation, MetS, and consequential disorders. This article describes selected adipokines and their potential role in both metabolic comorbidity and skin inflammation in psoriasis.
authors.affiliation: Psoriasis Research and Treatment Center, Department of Dermatology and Allergy & Institute of Medical Immunology, University Medicine Charité, Charitéplatz 1, 10117, Berlin, Germany. kerstin.wolk@charite.de.|Berlin-Brandenburg Center of Regenerative Therapies, University Medicine Charité, Augustenburger Platz 1, 13353, Berlin, Germany. kerstin.wolk@charite.de.
authors.forename: Kerstin
authors.identifier: 0000-0002-7689-4130
authors.initials: K
authors.lastname: Wolk
authors.affiliation: Psoriasis Research and Treatment Center, Department of Dermatology and Allergy & Institute of Medical Immunology, University Medicine Charité, Charitéplatz 1, 10117, Berlin, Germany.|Research Center Immunosciences, University Medicine Charité, Charitéplatz 1, 10117, Berlin, Germany.
authors.forename: Robert
authors.initials: R
authors.lastname: Sabat
mesh_terms: D054392:Adipokines / Q000378:metabolism*; D006801:Humans; D007249:Inflammation / Q000276:immunology / Q000378:metabolism; D011565:Psoriasis / Q000276:immunology / Q000378:metabolism
chemical_list: D054392:Adipokines
keywords: Adiponectin; Chemerin; Fetuin-A; Obesity; Omentin; Psoriasis arthritis