title: Evaluation of an Amino Acid-Based Formula in Infants Not Responding to Extensively Hydrolyzed Protein Formula.
abstract: Nearly 2% to 3% of infants and children younger than 3 years have confirmed cow's milk protein allergy with multiple clinical presentations including atopic dermatitis (AD), diarrhea, and vomiting/spitting up. Although most infants with cow's milk protein allergy experience clinical improvement with the use of an extensively hydrolyzed (EH) formula, highly sensitive infants may require an amino acid-based formula. In this observational, prospective study, 30 infants (1-12 months of age) with a history of weight loss and persistent allergic manifestations while on an EH formula were provided an amino acid-based formula for 12 weeks. Mean weight gain (z score change) improved +0.43 ± 0.28 (mean ± standard deviation) after the 12-week feeding period. Improvement was observed for many allergic symptoms including significant decreases in AD severity (P = 0.02). These results indicate the new amino acid-based infant formula supported healthy weight gain and improvement in allergic manifestations in infants not responding to EH formulas.
authors.affiliation: *Boston Children's Hospital, Boston, MA †Mead Johnson Nutrition, Evansville, IN ‡Private Practice, 104 Avenue Victor Hugo, Boulogne, France.
authors.forename: Jon
authors.initials: J
authors.lastname: Vanderhoof
authors.forename: Nancy
authors.initials: N
authors.lastname: Moore
authors.forename: Delphine
authors.initials: D
authors.lastname: de Boissieu
mesh_terms: D000596:Amino Acids / Q000008:administration & dosage*; D002657:Child Development; D005260:Female; D005526:Food, Formulated; D006801:Humans; D006868:Hydrolysis; D007223:Infant; D041943:Infant Formula / Q000737:chemistry*; D008297:Male; D016269:Milk Hypersensitivity / Q000178:diet therapy*; D011446:Prospective Studies
chemical_list: D000596:Amino Acids