title: An intracellular anchor regulates the distribution of bioactive molecules.
abstract: Based on bioorthogonal tetrazine ligation, a pre-targeted anchor strategy was developed to regulate the intracellular distribution of bioactive molecules. This strategy could solve the issue regarding the permeability and targeting ability of bioactive molecules in the specific organelles of living cells.
authors.affiliation: Beijing National Laboratory for Molecular Science, Key Laboratory of Organic Solids, Institute of Chemistry, Chinese Academy of Sciences, Beijing, 100190, P. R. China. wangshu@iccas.ac.cn.
authors.forename: Jianwu
authors.initials: J
authors.lastname: Wang
authors.forename: Shengliang
authors.initials: S
authors.lastname: Li
authors.forename: Hui
authors.initials: H
authors.lastname: Chen
authors.forename: Rong
authors.initials: R
authors.lastname: Hu
authors.forename: Meng
authors.initials: M
authors.lastname: Li
authors.forename: Fengting
authors.initials: F
authors.lastname: Lv
authors.forename: Libing
authors.initials: L
authors.lastname: Liu
authors.forename: Yuguo
authors.initials: Y
authors.lastname: Ma
authors.forename: Shu
authors.initials: S
authors.lastname: Wang
mesh_terms: D000072283:A549 Cells; D002851:Chromatography, High Pressure Liquid; D034242:Cyclooctanes / Q000737:chemistry; D003593:Cytoplasm / Q000737:chemistry / Q000378:metabolism; D004317:Doxorubicin / Q000737:chemistry; D005456:Fluorescent Dyes / Q000737:chemistry; D006056:Golgi Apparatus / Q000737:chemistry / Q000378:metabolism; D006801:Humans; D061986:MCF-7 Cells; D018613:Microscopy, Confocal; D008928:Mitochondria / Q000737:chemistry / Q000378:metabolism; D013777:Tetrazoles / Q000737:chemistry*
chemical_list: D034242:Cyclooctanes; D005456:Fluorescent Dyes; D013777:Tetrazoles; D004317:Doxorubicin