title: Disordered arrangements of basal cells as a prognostic factor for oral epithelial dysplasia: a morphometric study of 96 cases.
abstract: OBJECTIVE
  The aim of this study was to assess objectively the predictive value of the atypical appearance of the basal layer of oral epithelial dysplasia (OED) for development into invasive carcinoma.
  
  
  METHODS
  Ninety-six OED cases were examined. These cases were divided into 2 groups: 38 cases that developed into invasive carcinoma and 58 cases that did not. Furthermore, 12 histopathological factors were quantified morphometrically in each case and assessed by Cox's proportional hazards model.
  
  
  RESULTS
  The standard deviation of the length between the apical membrane of the basal cells and the basement membrane was significantly associated with development of OED into invasive carcinoma (P < .001; hazard ratio, 3.124).
  
  
  CONCLUSIONS
  We provided novel, objective data demonstrating that an atypical appearance, especially the disordered arrangement of the basal cells representing loss of polarity, may be useful for predicting the development of OED into invasive carcinoma of the tongue.
authors.affiliation: PhD Student, Department of Maxillofacial Surgery, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan.
authors.forename: Takeshi
authors.initials: T
authors.lastname: Okamura
authors.affiliation: Associate Professor, Department of Diagnostic Oral Pathology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan. Electronic address: Izumo.dlab@tmd.ac.jp.
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Izumo
authors.affiliation: Professor, Division of Oral Diagnosis, Dental and Maxillofacial Radiology and Oral Pathology Diagnostic Services, Nippon Dental University Hospital, Tokyo, Japan.
authors.forename: Hisao
authors.initials: H
authors.lastname: Yagishita
authors.affiliation: Staff Scientist, Department of Clinical Laboratory and Pathology, National Cancer Center Hospital, Tokyo, Japan.
authors.forename: Taisuke
authors.initials: T
authors.lastname: Mori
authors.affiliation: Lecturer, Department of Oral Pathology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan.
authors.forename: Kei
authors.initials: K
authors.lastname: Sakamoto
authors.affiliation: Professor of Department of Maxillofacial Surgery, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan.
authors.forename: Kiyoshi
authors.initials: K
authors.lastname: Harada
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001485:Basement Membrane / Q000473:pathology; D001706:Biopsy; D002280:Basal Cell Carcinoma / Q000473:pathology*; D004847:Epithelial Cells / Q000473:pathology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009061:Mouth Mucosa / Q000473:pathology*; D011230:Precancerous Conditions / Q000473:pathology*; D011237:Predictive Value of Tests; D011379:Prognosis; D014062:Tongue Neoplasms / Q000473:pathology*