title: Nonalcoholic Fatty Liver Is Not Associated with the Relationship between Insulin Secretion and Insulin Sensitivity in Obese Children: Matched Case-Control Study.
abstract: No study so far has evaluated the relationship between insulin secretion (ISEC) and insulin sensitivity (ISEN) in pediatric nonalcoholic fatty liver disease (NAFLD). We evaluated the relationship between ISEC and ISEN in young obese patients with and without NAFLD.
  
  
  
  We matched 401 NAFLD+and 595 NAFLD-children by sex (same), age (≤1 year), pubertal status (same), and body mass index (BMI; ≤0.05 standard deviation scores) using coarsened exact matching. The insulinogenic index and the ratio between the incremental areas under the curve of insulin and glucose were used as indices of ISEC. The quantitative ISEN check index, the oral glucose ISEN index, the Stumvoll index, and the Matsuda ISEN index were used as indices of ISEN. The association of NAFLD with the relationship between ISEC (response) and ISEN (predictor) was evaluated using median regression.
  
  
  
  The NAFLD·ISEN interaction was not significant in any regression model, implying commons slopes for NAFLD+and NAFLD-children. When such interaction was removed from the models, the NAFLD term was not significant, implying commons intercepts for NAFLD+and NAFLD-children.
  
  
  
  NAFLD is not associated with the relationship between ISEN and ISEC in young obese children strictly matched for sex, age, pubertal status, and BMI.
authors.affiliation: 1 Liver Research Center , Basovizza, Trieste, Italy .|2 International Center for the Assessment of Nutritional Status (ICANS), University of Milan , Milan, Italy .
authors.forename: Giorgio
authors.initials: G
authors.lastname: Bedogni
authors.affiliation: 3 Institute of Neuroscience , National Research Council, Padua, Italy .
authors.forename: Andrea
authors.initials: A
authors.lastname: Mari
authors.affiliation: 4 Laboratorio Sperimentale Ricerche Auxo-endocrinologiche, Istituto Auxologico Italiano , IRCCS, Milan and Verbania, Italy .
authors.forename: Alessandra
authors.initials: A
authors.lastname: De Col
authors.affiliation: 4 Laboratorio Sperimentale Ricerche Auxo-endocrinologiche, Istituto Auxologico Italiano , IRCCS, Milan and Verbania, Italy .
authors.forename: Nicoletta
authors.initials: N
authors.lastname: Marazzi
authors.affiliation: 1 Liver Research Center , Basovizza, Trieste, Italy .|5 Department of Medical Sciences, University of Trieste , Trieste, Italy .
authors.forename: Claudio
authors.initials: C
authors.lastname: Tiribelli
authors.affiliation: 6 Research Area for Multifactorial Diseases and Complex Phenotypes, Bambino Gesù Children's Hospital , Rome, Italy .
authors.forename: Melania
authors.initials: M
authors.lastname: Manco
authors.affiliation: 4 Laboratorio Sperimentale Ricerche Auxo-endocrinologiche, Istituto Auxologico Italiano , IRCCS, Milan and Verbania, Italy .|7 Istituto Auxologico Italiano, IRCCS, Divisione di Auxologia , Verbania, Italy .
authors.forename: Alessandro
authors.initials: A
authors.lastname: Sartorio
mesh_terms: D000293:Adolescent; D016022:Case-Control Studies; D002648:Child; D005260:Female; D005951:Glucose Tolerance Test; D006801:Humans; D007328:Insulin / Q000378:metabolism*; D007333:Insulin Resistance; D000078790:Insulin Secretion; D007558:Italy / Q000453:epidemiology; D008099:Liver / Q000000981:diagnostic imaging / Q000378:metabolism* / Q000473:pathology*; D008297:Male; D065626:Non-alcoholic Fatty Liver Disease / Q000453:epidemiology / Q000378:metabolism* / Q000473:pathology; D063766:Pediatric Obesity / Q000150:complications / Q000453:epidemiology / Q000378:metabolism*; D011627:Puberty / Q000378:metabolism; D012307:Risk Factors
chemical_list: D007328:Insulin