title: Fluorescence Dye Loaded Nano-graphene for Multimodal Imaging Guided Photothermal Therapy.
abstract: Photoacoustic imaging (PA) has emerged as a novel and noninvasive imaging modality owing to its high spatial resolution and high soft tissue contrast. Herein, we loaded a near-infrared (NIR) fluorescence dye (CySCOOH) onto the surface of PEGylated graphene oxide (GO) via π-π stacking to increase the NIR absorbance of GO. The PA imaging proved that PEGylated GO-CysCOOH (GO-PEG-CysCOOH) significantly enhances the PA signal in the tumor site compared with free GO-PEG. We then utilized the strong optical absorbance of GO-PEG-CySCOOH in the NIR region forin vivophotothermal therapy, achieving efficient tumor ablation after intravenous injection of GO-PEG-CySCOOH and low-power laser irradiation on the tumor. Our results indicate that this graphene-based nanocomposite can be developed as a promising contrast agent for PA imaging and a thermal agent for imaging guided photothermal therapy.
authors.affiliation: Department of Radiology, The Third Xiangya Hospital, Central South University, Changsha, Hunan 410013, China; Laboratory of Molecular Imaging and Nanomedicine (LOMIN), National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH), Bethesda, Maryland 20892, United States; State Key Laboratory for Powder Metallurgy, Central South University, Changsha, Hunan, 410083, China.
authors.forename: Pengfei
authors.initials: P
authors.lastname: Rong
authors.affiliation: Department of Radiology, The Third Xiangya Hospital, Central South University, Changsha, Hunan 410013, China.
authors.forename: Jianzhen
authors.initials: J
authors.lastname: Wu
authors.affiliation: School of Pharmaceutical Sciences, Central South University, Changsha, 410013, PR China.
authors.forename: Zhiguo
authors.initials: Z
authors.lastname: Liu
authors.affiliation: Department of Radiology, The Third Xiangya Hospital, Central South University, Changsha, Hunan 410013, China.
authors.forename: Xiaoqian
authors.initials: X
authors.lastname: Ma
authors.affiliation: School of Pharmaceutical Sciences, Central South University, Changsha, 410013, PR China.
authors.forename: Lun
authors.initials: L
authors.lastname: Yu
authors.affiliation: State Key Laboratory for Powder Metallurgy, Central South University, Changsha, Hunan, 410083, China.
authors.forename: Kechao
authors.initials: K
authors.lastname: Zhou
authors.affiliation: School of Pharmaceutical Sciences, Central South University, Changsha, 410013, PR China.
authors.forename: Wenbin
authors.initials: W
authors.lastname: Zeng
authors.affiliation: Department of Radiology, The Third Xiangya Hospital, Central South University, Changsha, Hunan 410013, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Wang