title: High Frequency of Bone Marrow Involvement in Intravascular Large B-Cell Lymphoma.
abstract: Intravascular large B-cell lymphoma (IVLBCL) is a rare subtype of diffuse large B-cell lymphoma. Thirteen cases of IVLBCL with a median age of 56 years were analyzed retrospectively. Nonspecific symptoms such as fever and hepatosplenomegaly were the most common manifestations, and the bone marrow was usually involved in 8/13 (61.5%) cases. All tumors expressed CD20, and 12/13 (92.3%) of the tumors exhibited a nongerminal center phenotype by Hans algorithm. CD5 was expressed in 3/12 (25%) of the tumors. MYC was negative in all cases, and BCL2 was positive in 10/12 (83.3%) cases. Cytogenetic analysis revealed 5 cases that did not have rearrangements in either the MYC or the BCL2 gene. No association with Epstein-Barr virus was found. Seven of 11 patients received chemotherapy. The median survival time was 6 months. Patients with hemophagocytic syndrome had poor prognoses. Our study demonstrates that IVLBCL has a poor clinical outcome with a high frequency of bone marrow involvement and that the MYC gene may not play an important role in the poor prognosis of IVLBCL.
authors.affiliation: 1 West China Hospital, Sichuan University, Chengdu, Sichuan, China.
authors.forename: Jianchao
authors.initials: J
authors.lastname: Wang
authors.affiliation: 1 West China Hospital, Sichuan University, Chengdu, Sichuan, China.
authors.forename: Wenshuang
authors.initials: W
authors.lastname: Ding
authors.affiliation: 1 West China Hospital, Sichuan University, Chengdu, Sichuan, China.
authors.forename: Limin
authors.initials: L
authors.lastname: Gao
authors.affiliation: 1 West China Hospital, Sichuan University, Chengdu, Sichuan, China.
authors.forename: Wenqing
authors.initials: W
authors.lastname: Yao
authors.affiliation: 1 West China Hospital, Sichuan University, Chengdu, Sichuan, China.
authors.forename: Min
authors.initials: M
authors.lastname: Chen
authors.affiliation: 1 West China Hospital, Sichuan University, Chengdu, Sichuan, China.
authors.forename: Sha
authors.initials: S
authors.lastname: Zhao
authors.affiliation: 1 West China Hospital, Sichuan University, Chengdu, Sichuan, China.
authors.forename: Weiping
authors.initials: W
authors.lastname: Liu
authors.affiliation: 1 West China Hospital, Sichuan University, Chengdu, Sichuan, China.
authors.forename: Wenyan
authors.initials: W
authors.lastname: Zhang
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000032:analysis; D001853:Bone Marrow / Q000473:pathology*; D002681:China; D018572:Disease-Free Survival; D005260:Female; D016259:Genes, myc; D006801:Humans; D007150:Immunohistochemistry; D017404:In Situ Hybridization, Fluorescence; D053208:Kaplan-Meier Estimate; D016403:Lymphoma, Large B-Cell, Diffuse / Q000235:genetics / Q000401:mortality / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000235:genetics; D012189:Retrospective Studies; D019043:Vascular Neoplasms / Q000235:genetics / Q000401:mortality / Q000473:pathology*
chemical_list: C000595707:BCL2 protein, human; D014408:Biomarkers, Tumor; D019253:Proto-Oncogene Proteins c-bcl-2
keywords: BCL2; MYC; bone marrow involvement; clinicopathological; intravascular large B-cell lymphoma