title: The role of Trim25 in development, disease and RNA metabolism.
abstract: Trim25 is a member of the tripartite motif family of E3 ubiquitin ligases. It plays major roles in innate immunity and defence against viral infection, control of cell proliferation and migration of cancer cells. Recent work identified Trim25 as being able to bind to RNA and to regulate Lin28a-mediated uridylation of pre-let-7. Here we review the current knowledge of the role of Trim25 in development, disease and RNA metabolism.
authors.affiliation: Wellcome Trust Centre for Cell Biology, University of Edinburgh, Michael Swann Building, Edinburgh EH9 3BF, U.K.
authors.forename: Gregory
authors.initials: G
authors.lastname: Heikel
authors.affiliation: Wellcome Trust Centre for Cell Biology, University of Edinburgh, Michael Swann Building, Edinburgh EH9 3BF, U.K.
authors.forename: Nila Roy
authors.initials: NR
authors.lastname: Choudhury
authors.affiliation: Wellcome Trust Centre for Cell Biology, University of Edinburgh, Michael Swann Building, Edinburgh EH9 3BF, U.K. gmichlew@staffmail.ed.ac.uk.
authors.forename: Gracjan
authors.initials: G
authors.lastname: Michlewski
mesh_terms: D000818:Animals; D004268:DNA-Binding Proteins / Q000235:genetics / Q000378:metabolism; D004194:Disease / Q000235:genetics*; D005260:Female; D006801:Humans; D051379:Mice; D008957:Models, Genetic; D012313:RNA / Q000235:genetics* / Q000378:metabolism; D014157:Transcription Factors / Q000235:genetics* / Q000378:metabolism; D000070584:Tripartite Motif Proteins / Q000235:genetics* / Q000378:metabolism; D044767:Ubiquitin-Protein Ligases / Q000235:genetics* / Q000378:metabolism; D014599:Uterus / Q000254:growth & development / Q000378:metabolism*
chemical_list: D004268:DNA-Binding Proteins; D014157:Transcription Factors; C490034:Trim25 protein, mouse; D000070584:Tripartite Motif Proteins; D012313:RNA; C084523:TRIM25 protein, human; D044767:Ubiquitin-Protein Ligases
keywords: E3 ubiquitin ligase; RNA metabolism; Trim25; novel RNA-binding proteins