title: [Genotypes of adenoviruses in infants and young children with diarrhea].
abstract: OBJECTIVE
  To investigate the prevalence of adenoviruses (AdV) and their genotypes in infants and young children with diarrhea.
  
  
  METHODS
  A total of 380 children with diarrhea aged less than 3 years were enrolled. The genomic DNA was extracted from stool and PCR was used to detect AdV. Clone sequencing and genotyping were performed for DNA in AdV-positive specimens.
  
  
  RESULTS
  AdV was detected in 24 out of 380 specimens, and the detection rate was 6.3% (24/380). A majority of children with positive AdV were aged 2-3 years. The viral sequence analysis of positive specimens showed that the detection rates of enteric AdV41 and non-enteric AdV were 4.2% (16/380) and 2.1% (8/380), respectively, and among the children with non-enteric AdV, there were 2 with AdV1, 2 with AdV2, 1 with AdV7, 2 with AdV12, and 1 with AdV31.
  
  
  CONCLUSIONS
  Diarrhea caused by AdV is commonly seen in children aged 2-3 years, and AdV41 is the major predominant strain.
authors.affiliation: Department of Pediatrics, First Hospital of Shizuishan Affiliated to Ningxia Medical University, Shizuishan, Ningxia 753200, China. zql128109@163.com.
authors.forename: Qiu-Li
authors.initials: QL
authors.lastname: Zhang
authors.forename: Hong-Bo
authors.initials: HB
authors.lastname: Wang
authors.forename: Yan-Ling
authors.initials: YL
authors.lastname: Wang
authors.forename: Jian-Sheng
authors.initials: JS
authors.lastname: Zhou
authors.forename: Juan
authors.initials: J
authors.lastname: Cai
authors.forename: Rui-Rong
authors.initials: RR
authors.lastname: He
mesh_terms: D000256:Adenoviridae / Q000145:classification / Q000235:genetics*; D002675:Child, Preschool; D003967:Diarrhea / Q000821:virology*; D005260:Female; D005838:Genotype; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male