title: Characterization of the surface properties of MgO using paper spray mass spectrometry.
abstract: BACKGROUND
  Significant advances have been made in the preparation of different morphologies of magnesium oxide (MgO), but the relationship between MgO morphology and its interactions with therapeutic drugs is rarely studied. Herein, we investigated the interactions between different morphologies of MgO and therapeutic drugs using paper spray mass spectrometry.
  
  
  METHODS
  Different morphologies of MgO including trapezoidal, needle-like, flower-like and nest-like structures were prepared through a facile precipitation method. The as-obtained MgO particles were then coated onto the surface of filter paper via vacuum filtration strategy. The coated papers with different morphologies of MgO were used as the substrates for paper spray mass spectrometry to explore the interactions between different MgO and therapeutic drugs.
  
  
  RESULTS
  Through investigating the interactions between different morphologies of MgO coated papers and therapeutic drugs, it demonstrated that, in contrast to the trapezoidal, needle-like and nest-like MgO coated papers, different drugs in dried blood spots (DBS) were more favourably eluted off from the paper coated with flower-like MgO due to its weaker surface basicity. Also, the signal intensities of different drugs during paper spray were highly dependent on their elution behaviours.
  
  
  CONCLUSIONS
  Paper spray mass spectrometry (MS) provides an avenue to elaborate the surface properties of MgO with different structures. The surface basicity of MgO played a crucial role in determining the elution behaviours of therapeutic drugs in DBS, and a more favourable elution behaviour tended to result in a higher MS signal. Copyright © 2016 John Wiley & Sons, Ltd.
authors.affiliation: School of Chemistry and Chemical Engineering, Xi'an Shiyou University, Xi'an, 710065, China.
authors.forename: Yajun
authors.initials: Y
authors.lastname: Zheng
authors.affiliation: School of Chemistry and Chemical Engineering, Xi'an Shiyou University, Xi'an, 710065, China.
authors.forename: Xiaoling
authors.initials: X
authors.lastname: Zhang
authors.affiliation: School of Chemistry and Chemical Engineering, Xi'an Shiyou University, Xi'an, 710065, China.
authors.forename: Zongquan
authors.initials: Z
authors.lastname: Bai
authors.affiliation: School of Chemistry and Chemical Engineering, Xi'an Shiyou University, Xi'an, 710065, China.
authors.forename: Zhiping
authors.initials: Z
authors.lastname: Zhang
mesh_terms: D059788:Dried Blood Spot Testing / Q000295:instrumentation / Q000379:methods; D006801:Humans; D008277:Magnesium Oxide / Q000138:chemical synthesis / Q000737:chemistry*; D013058:Mass Spectrometry / Q000295:instrumentation / Q000379:methods*; D008855:Microscopy, Electron, Scanning; D010209:Paper; D004364:Pharmaceutical Preparations / Q000032:analysis / Q000737:chemistry*; D013499:Surface Properties
chemical_list: D004364:Pharmaceutical Preparations; D008277:Magnesium Oxide