title: Exposure to bisphenol A and the development of asthma: A systematic review of cohort studies.
abstract: There is conflicting evidence about the association between bisphenol A (BPA) exposure and childhood asthma risk. We aimed to review the epidemiological literature on the relationship between prenatal or postnatal exposure to BPA and the risk of childhood asthma/wheeze.
  
  
  
  The PubMed database was systematically searched, and additional studies were found by searching reference lists of relevant articles.
  
  
  
  Six studies fulfilled the eligibility criteria. Three studies found that prenatal BPA exposure is associated with an increased risk of childhood wheeze, while another study reported a reduced risk of wheeze. Regarding the postnatal BPA exposure, three studies demonstrated an increased risk of childhood asthma/wheeze.
  
  
  
  The mean prenatal BPA was associated with the risk of childhood wheeze/asthma. Besides, the influence of BPA exposure during the second trimester of pregnancy on the prevalence of childhood wheeze was marked. Further studies are urgently needed to explore the underlying mechanism about adverse effect of BPA exposure on childhood wheeze/asthma.
authors.affiliation: Department of Epidemiology and Health Statistics, School of Public Health, Anhui Medical University, Hefei, Anhui 230032, China.
authors.forename: Ming-Yu
authors.initials: MY
authors.lastname: Xie
authors.affiliation: Anhui Province Children's hospital, Hefei, Anhui 230051, China.
authors.forename: Hong
authors.initials: H
authors.lastname: Ni
authors.affiliation: Department of Epidemiology and Health Statistics, School of Public Health, Anhui Medical University, Hefei, Anhui 230032, China.
authors.forename: De-Sheng
authors.initials: DS
authors.lastname: Zhao
authors.affiliation: Department of Epidemiology and Health Statistics, School of Public Health, Anhui Medical University, Hefei, Anhui 230032, China.
authors.forename: Li-Ying
authors.initials: LY
authors.lastname: Wen
authors.affiliation: Department of Epidemiology and Health Statistics, School of Public Health, Anhui Medical University, Hefei, Anhui 230032, China.
authors.forename: Ke-Sheng
authors.initials: KS
authors.lastname: Li
authors.affiliation: Department of Epidemiology and Health Statistics, School of Public Health, Anhui Medical University, Hefei, Anhui 230032, China.
authors.forename: Hui-Hui
authors.initials: HH
authors.lastname: Yang
authors.affiliation: Department of Epidemiology and Health Statistics, School of Public Health, Anhui Medical University, Hefei, Anhui 230032, China.
authors.forename: Shu-Si
authors.initials: SS
authors.lastname: Wang
authors.affiliation: Department of Epidemiology and Health Statistics, School of Public Health, Anhui Medical University, Hefei, Anhui 230032, China.
authors.forename: Heng
authors.initials: H
authors.lastname: Zhang
authors.affiliation: Department of Epidemiology and Health Statistics, School of Public Health, Anhui Medical University, Hefei, Anhui 230032, China. Electronic address: suhong5151@sina.com.
authors.forename: Hong
authors.initials: H
authors.lastname: Su
mesh_terms: D001249:Asthma / Q000453:epidemiology*; D001559:Benzhydryl Compounds; D015331:Cohort Studies; D004781:Environmental Exposure; D004785:Environmental Pollutants; D005260:Female; D006801:Humans; D008431:Maternal-Fetal Exchange; D010636:Phenols; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D012135:Respiratory Sounds; D012307:Risk Factors; D000098826:Bisphenol A Compounds
chemical_list: D001559:Benzhydryl Compounds; D004785:Environmental Pollutants; D010636:Phenols; C006780:bisphenol A; D000098826:Bisphenol A Compounds
keywords: Asthma; Biphenol A; Childhood; Systematic review; Wheeze