title: Mathematical model of the effect of intercellular cooperative interactions in cancer during drug therapy.
abstract: We present an agent-based model of head and neck cancer cell population dynamics that investigates the effect of cooperative interactions between individual cancer cells during the course of cytotoxic drug treatment. A model of cooperative behavior based on the Lotka-Volterra competition equations is combined with a model of drug resistance and response. Predictions regarding the individual and combination effects of cooperation and drug treatment qualitatively match experimental observations from the literature.
authors.affiliation: Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, GA 30332 USA.
authors.forename: Chanchala D
authors.initials: CD
authors.lastname: Kaddi
authors.affiliation: Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, GA 30332 USA (phone: 404-385-5059).
authors.forename: May D
authors.initials: MD
authors.lastname: Wang