title: The relationship between serum paraoxonase levels and carotid atherosclerotic plaque formation in Alzheimer's patients.
abstract: Low paraoxonase 1 (PON1) activity and carotid atherosclerosis have been suggested to be important risk factors for dementia. However, the studies to date could not fully clarify the relationship between PON1, carotid atherosclerosis and dementia. The present study aimed to measure carotid atherosclerosis and PON1 activity in Alzheimer's Disease and to evaluate the relationship between them. The study included 25 Alzheimer's patients and 25 control subjects, for a total of 50 individuals. The study measured the serum PON1 activity and other biochemical parameters and carotid atherosclerotic plaque values of the participants. The mean paraoxonase activity (31.06±2.31U/L) was significantly lower in the Alzheimer's group compared to the control group (59.05±7.05U/L) (P<0.001). Nonetheless, the carotid plaque values were significantly higher in the patient group (3.02±0.52mm) compared to the control group (1.84±0.45mm) (P<0.001). Furthermore, there was a negative correlation (81.0%) between PON1 activity and carotid plaque in the overall study group (P<0.05). Also serum homocystein level was higher in the patient group (22.15±7.05) compared to the control group (13.30±3.32). In conclusion, our findings show inverse association between PON1 activity and carotid atherosclerosis in Alzheimer patients: the lower the PON1 activity the more progressed the atherosclerotic process in AD.
authors.affiliation: Department of Biochemistry, Faculty of Science, Yuzuncu Yil University, Van, Turkey. Electronic address: ayse.ars12@gmail.com.
authors.forename: Ayşe
authors.initials: A
authors.lastname: Arslan
authors.affiliation: Department of Neurology, Private Kocaeli Hospital Center, Kocaeli, Turkey. Electronic address: fatmaaykan@gmail.com.
authors.forename: Fatma Aykan
authors.initials: FA
authors.lastname: Tüzün
authors.affiliation: Department of Radiology, Yuzuncu Yil University, Dursun Odabası Faculty of Medicine, Van, Turkey. Electronic address: harun.ars75@gmail.com.
authors.forename: Harun
authors.initials: H
authors.lastname: Arslan
authors.affiliation: Department of Biochemistry, Faculty of Science, Yuzuncu Yil University, Van, Turkey.
authors.forename: Halit
authors.initials: H
authors.lastname: Demir
authors.affiliation: Department of Neurology, Private Sincan Koru Hospital, Ankara, Turkey. Electronic address: sybeltamer@gmail.com.
authors.forename: Sibel
authors.initials: S
authors.lastname: Tamer
authors.affiliation: Yuzuncu Yil University, Vocational Schools of Health Services, Van, Turkey. Electronic address: canantasin@gmail.com.
authors.forename: Canan
authors.initials: C
authors.lastname: Demir
authors.affiliation: Department of Neurology, Dicle University, Diyarbakır, Turkey. Electronic address: muhteremtasin@gmail.com.
authors.forename: Muhterem
authors.initials: M
authors.lastname: Tasin
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000201:enzymology* / Q000453:epidemiology; D043303:Aryldialkylphosphatase / Q000097:blood*; D002340:Carotid Artery Diseases / Q000000981:diagnostic imaging / Q000201:enzymology / Q000453:epidemiology; D016893:Carotid Stenosis / Q000000981:diagnostic imaging / Q000201:enzymology* / Q000453:epidemiology; D016022:Case-Control Studies; D005260:Female; D006710:Homocysteine / Q000097:blood; D006801:Humans; D008297:Male; D008875:Middle Aged; D058226:Plaque, Atherosclerotic / Q000000981:diagnostic imaging / Q000201:enzymology* / Q000453:epidemiology; D012307:Risk Factors; D014463:Ultrasonography
chemical_list: D006710:Homocysteine; D043303:Aryldialkylphosphatase; C468406:PON1 protein, human
keywords: Alzheimer's disease; Carotid atherosclerosis; Homocystein; PON1