title: Rewired NFκB signaling as a potentially actionable feature of activated B-cell-like diffuse large B-cell lymphoma.
abstract: Diffuse large B-cell lymphoma (DLBCL) is the most common type of aggressive lymphoma in the Western world and remains a clinical challenge. Two types of DLBCL are distinguishable, namely a germinal center B-cell-like phenotype (GCB) and an activated B-cell-like phenotype (ABC). Particularly ABC-DLBCL is difficult to treat, as this subentity typically displays resistance against frontline chemo-immune therapy. Through the availability of novel experimental technologies, such as next-generation sequencing and cutting-edge mouse models, we recently caught an unprecedentedly detailed glimpse at the genomic and biological features of ABC-DLBCL. Currently, a picture is emerging which suggests that ABC-DLBCL critically depends on sustained activity of the NFκB pathway, which, among others, is achieved through numerous distinct genetic aberrations, including CD79A/B-, CARD11-, and MYD88 mutations. Further genomic aberrations include amplifications of BCL2 and inactivating mutations in PRMD1. These molecular insights have spurred the development of novel autochthonous mouse models that faithfully mimic the biology and genetics of human ABC-DLBCL and could serve as preclinical platforms in future experiments. Furthermore, our genomic understanding of the disease now enables us to develop and validate novel targeted therapeutic intervention strategies that aim at decapitating non-physiological NFκB activity and repressing anti-apoptotic BCL2 signaling. In this review, we highlight these recent developments and make suggestions for further tool development and the design and stratification of future clinical trials.
authors.affiliation: Department I of Internal Medicine, University Hospital of Cologne, Cologne, Germany.|Cologne Excellence Cluster on Cellular Stress Response in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany.
authors.forename: Gero
authors.initials: G
authors.lastname: Knittel
authors.affiliation: Department I of Internal Medicine, University Hospital of Cologne, Cologne, Germany.|Cologne Excellence Cluster on Cellular Stress Response in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany.
authors.forename: Paul
authors.initials: P
authors.lastname: Liedgens
authors.affiliation: Department I of Internal Medicine, University Hospital of Cologne, Cologne, Germany.|Cologne Excellence Cluster on Cellular Stress Response in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany.
authors.forename: Darya
authors.initials: D
authors.lastname: Korovkina
authors.affiliation: Department I of Internal Medicine, University Hospital of Cologne, Cologne, Germany.|Center of Integrated Oncology (CIO), University Hospital of Cologne, Cologne, Germany.
authors.forename: Christian P
authors.initials: CP
authors.lastname: Pallasch
authors.affiliation: Department I of Internal Medicine, University Hospital of Cologne, Cologne, Germany.|Cologne Excellence Cluster on Cellular Stress Response in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany.|Center of Integrated Oncology (CIO), University Hospital of Cologne, Cologne, Germany.|Center of Molecular Medicine, University of Cologne, Cologne, Germany.
authors.forename: Hans Christian
authors.initials: HC
authors.lastname: Reinhardt
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000235:genetics / Q000276:immunology; D001402:B-Lymphocytes / Q000276:immunology / Q000378:metabolism* / Q000473:pathology; D014408:Biomarkers, Tumor; D053468:CARD Signaling Adaptor Proteins / Q000235:genetics / Q000378:metabolism; D051925:CD79 Antigens / Q000235:genetics / Q000378:metabolism; D002986:Clinical Trials as Topic; D004195:Disease Models, Animal; D055808:Drug Discovery; D004353:Drug Evaluation, Preclinical; D014644:Genetic Variation; D006162:Guanylate Cyclase / Q000235:genetics / Q000378:metabolism; D006801:Humans; D016130:Immunophenotyping; D008213:Lymphocyte Activation; D016403:Lymphoma, Large B-Cell, Diffuse / Q000188:drug therapy / Q000209:etiology / Q000378:metabolism* / Q000473:pathology; D051379:Mice; D008822:Mice, Transgenic; D058990:Molecular Targeted Therapy; D053594:Myeloid Differentiation Factor 88 / Q000235:genetics / Q000378:metabolism; D016328:NF-kappa B / Q000378:metabolism*; D010641:Phenotype; D010950:Plasma Cells / Q000378:metabolism / Q000473:pathology; D015398:Signal Transduction; D000072598:Tumor Necrosis Factor alpha-Induced Protein 3 / Q000235:genetics / Q000378:metabolism
chemical_list: D014408:Biomarkers, Tumor; D053468:CARD Signaling Adaptor Proteins; D051925:CD79 Antigens; D053594:Myeloid Differentiation Factor 88; D016328:NF-kappa B; D000072598:Tumor Necrosis Factor alpha-Induced Protein 3; C426242:CARD11 protein, human; D006162:Guanylate Cyclase
keywords: malignant lymphoma; non-Hodgkin's lymphoma