title: Block Copolymer Membranes for Efficient Capture of a Chemotherapy Drug.
abstract: We introduce the use of block copolymer membranes for an emerging application, "drug capture". The polymer is incorporated in a new class of biomedical devices, referred to as ChemoFilter, which is an image-guided temporarily deployable endovascular device designed to increase the efficacy of chemotherapy-based cancer treatment. We show that block copolymer membranes consisting of functional sulfonated polystyrene end blocks and a structural polyethylene middle block (S-SES) are capable of capturing doxorubicin, a chemotherapy drug. We focus on the relationship between morphology of the membrane in the ChemoFilter device and efficacy of doxorubicin capture measured in vitro. Using small-angle X-ray scattering and cryogenic scanning transmission electron microscopy, we discovered that rapid doxorubicin capture is associated with the presence of water-rich channels in the lamellar-forming S-SES membranes in aqueous environment.
authors.affiliation: Materials Sciences Division and Energy Technologies Area, Lawrence Berkeley National Laboratory, Berkeley, California 94720, United States; Department of Chemical and Biomolecular Engineering, University of California-Berkeley, Berkeley, California 94720, United States.
authors.forename: X Chelsea
authors.initials: XC
authors.lastname: Chen
authors.affiliation: Department of Chemical and Biomolecular Engineering, University of California-Berkeley , Berkeley, California 94720, United States.
authors.forename: Hee Jeung
authors.initials: HJ
authors.lastname: Oh
authors.affiliation: Department of Radiology and Biomedical Imaging, University of California-San Francisco , San Francisco, California 94107, United States.
authors.forename: Jay F
authors.initials: JF
authors.lastname: Yu
authors.affiliation: Department of Radiology and Biomedical Imaging, University of California-San Francisco , San Francisco, California 94107, United States.
authors.forename: Jeffrey K
authors.initials: JK
authors.lastname: Yang
authors.affiliation: Department of Chemical and Biomolecular Engineering, University of California-Berkeley , Berkeley, California 94720, United States.
authors.forename: Nikos
authors.initials: N
authors.lastname: Petzetakis
authors.affiliation: Department of Radiology and Biomedical Imaging, University of California-San Francisco , San Francisco, California 94107, United States.
authors.forename: Anand S
authors.initials: AS
authors.lastname: Patel
authors.affiliation: Department of Radiology and Biomedical Imaging, University of California-San Francisco , San Francisco, California 94107, United States.
authors.forename: Steven W
authors.initials: SW
authors.lastname: Hetts
authors.affiliation: Materials Sciences Division and Energy Technologies Area, Lawrence Berkeley National Laboratory, Berkeley, California 94720, United States; Department of Chemical and Biomolecular Engineering, University of California-Berkeley, Berkeley, California 94720, United States; Materials Sciences Division and Energy Technologies Area, Lawrence Berkeley National Laboratory, Berkeley, California 94720, United States.
authors.forename: Nitash P
authors.initials: NP
authors.lastname: Balsara