title: Design, synthesis and evaluation of novel19F magnetic resonance sensitive protein tyrosine phosphatase inhibitors.
abstract: Fluorine is a highly attractive element for both medicinal chemistry and imaging technologies. To facilitate protein tyrosine phosphatases (PTPs)-targeted drug discovery and imaging-guided PTP research with fluorine, several highly potent and19F MR sensitive PTP inhibitors were discovered through a structure-based focused library strategy.
authors.affiliation: School of Pharmaceutical Sciences, Wuhan University, Wuhan 430071, China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Li
authors.affiliation: School of Pharmaceutical Sciences, Wuhan University, Wuhan 430071, China.
authors.forename: Guiquan
authors.initials: G
authors.lastname: Xia
authors.affiliation: School of Pharmaceutical Sciences, Wuhan University, Wuhan 430071, China.
authors.forename: Qi
authors.initials: Q
authors.lastname: Guo
authors.affiliation: Department of Medicinal Chemistry and Molecular Pharmacology, Center for Cancer Research, Purdue University, West Lafayette, Indiana 47907, USA.
authors.forename: Li
authors.initials: L
authors.lastname: Wu
authors.affiliation: State Key Laboratory for Magnetic Resonance and Atomic and Molecular Physics, Wuhan Institute of Physics and Mathematics, Chinese Academy of Sciences, Wuhan 430071, China.
authors.forename: Shizhen
authors.initials: S
authors.lastname: Chen
authors.affiliation: School of Pharmaceutical Sciences, Wuhan University, Wuhan 430071, China.
authors.forename: Zhigang
authors.initials: Z
authors.lastname: Yang
authors.affiliation: School of Pharmaceutical Sciences, Wuhan University, Wuhan 430071, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Wang
authors.affiliation: Department of Medicinal Chemistry and Molecular Pharmacology, Center for Cancer Research, Purdue University, West Lafayette, Indiana 47907, USA.
authors.forename: Zhong-Yin
authors.initials: ZY
authors.lastname: Zhang
authors.affiliation: State Key Laboratory for Magnetic Resonance and Atomic and Molecular Physics, Wuhan Institute of Physics and Mathematics, Chinese Academy of Sciences, Wuhan 430071, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Zhou
authors.affiliation: School of Pharmaceutical Sciences, Wuhan University, Wuhan 430071, China; State Key Laboratory for Magnetic Resonance and Atomic and Molecular Physics, Wuhan Institute of Physics and Mathematics, Chinese Academy of Sciences, Wuhan 430071, China; Key Laboratory of Synthetic Chemistry of Natural Substances, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China; State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, Donghua University, Shanghai 201620, China.
authors.forename: Zhong-Xing
authors.initials: ZX
authors.lastname: Jiang