title: Placental control of drug delivery.
abstract: The placenta serves as the interface between the maternal and fetal circulations and regulates the transfer of oxygen, nutrients, and waste products. When exogenous substances are present in the maternal bloodstream-whether from environmental contact, occupational exposure, medication, or drug abuse-the extent to which this exposure affects the fetus is determined by transport and biotransformation processes in the placental barrier. Advances in drug delivery strategies are expected to improve the treatment of maternal and fetal diseases encountered during pregnancy.
authors.affiliation: Department of Pharmacology & Toxicology, University of Texas Medical Branch, Galveston, TX 77555, USA.
authors.forename: Sanaalarab
authors.initials: S
authors.lastname: Al-Enazy
authors.affiliation: Department of Pharmacology & Toxicology, University of Texas Medical Branch, Galveston, TX 77555, USA.
authors.forename: Shariq
authors.initials: S
authors.lastname: Ali
authors.affiliation: Department of Pharmacology & Toxicology, King Saud University, Riyadh, Saudi Arabia.
authors.forename: Norah
authors.initials: N
authors.lastname: Albekairi
authors.affiliation: Department of Pharmacology, Tanta University, Tanta, Egypt.
authors.forename: Marwa
authors.initials: M
authors.lastname: El-Tawil
authors.affiliation: Department of Obstetrics & Gynecology, University of Texas Medical Branch, Galveston, TX 77555, USA. Electronic address: erik.rytting@utmb.edu.
authors.forename: Erik
authors.initials: E
authors.lastname: Rytting
mesh_terms: D016503:Drug Delivery Systems; D005260:Female; D006801:Humans; D008431:Maternal-Fetal Exchange; D010100:Oxygen; D004364:Pharmaceutical Preparations / Q000008:administration & dosage*; D010920:Placenta; D011247:Pregnancy
chemical_list: D004364:Pharmaceutical Preparations; D010100:Oxygen
keywords: Biotransformation; Placenta; Pregnancy; Transporters