title: Serum Anti-Müllerian Hormone Concentration in Young Women with Chronic Kidney Disease on Hemodialysis, and After Successful Kidney Transplantation.
abstract: OBJECTIVE
  In women with chronic kidney disease (CKD) fertility abnormalities occur frequently. Anti-Müllerian hormone (AMH) inhibits excessive recruitment of primordial follicles. The aim of the study was to evaluate the serum AMH concentration in women on hemodialysis and after kidney transplantation (KTx).
  
  
  METHODS
  46 hemodialysed women and 14 with CKD about to undergo kidney transplantation were enrolled into the study. The control group consisted of 40 healthy women. In all subjects serum concentration of AMH was determined (in chronic hemodialysis women and in control group once, and in women after KTx immediately before surgery, and 3 times after the transplantation).
  
  
  RESULTS
  Serum AMH concentration in hemodialysed women and in the control group did not differ significantly, while in hemodialysed women with regular menstrual cycles it was significantly lower than in the control group: 2.20 (1.08-3.55ng/ml) and 3.30 (1.80-6.10ng/ml) respectively, (p=0.02). In the KTx group, a significant decrease in serum AMH concentration was found from 3.30ng/ml (2.20-6.50ng/ml) at baseline to 1.90ng/ml (1.30-2.40ng/ml) at 6 months after KTx (p=0.007).
  
  
  CONCLUSIONS
  1. Significantly lower serum AMH concentration was found in the regularly menstruating CKD women on hemodialysis in comparison with the healthy controls. 2. Serum AMH decreased significantly after successful KTx.
authors.affiliation: Department of Nephrology, Transplantation and Internal Medicine, Medical University of Silesia, Katowice, Poland.
authors.forename: Ewelina
authors.initials: E
authors.lastname: Sikora-Grabka
authors.forename: Marcin
authors.initials: M
authors.lastname: Adamczak
authors.forename: Piotr
authors.initials: P
authors.lastname: Kuczera
authors.forename: Magdalena
authors.initials: M
authors.lastname: Szotowska
authors.forename: Paweł
authors.initials: P
authors.lastname: Madej
authors.forename: Andrzej
authors.initials: A
authors.lastname: Wiecek
mesh_terms: D054304:Anti-Mullerian Hormone / Q000097:blood*; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D016030:Kidney Transplantation / Q000009:adverse effects*; D008597:Menstrual Cycle; D006435:Renal Dialysis / Q000009:adverse effects*; D051436:Renal Insufficiency, Chronic / Q000097:blood* / Q000628:therapy; D055815:Young Adult
chemical_list: D054304:Anti-Mullerian Hormone