title: Reactive Oxygen Species Regulate T Cell Immune Response in the Tumor Microenvironment.
abstract: Reactive oxygen species (ROS) produced by cellular metabolism play an important role as signaling messengers in immune system. ROS elevated in the tumor microenvironment are associated with tumor-induced immunosuppression. T cell-based therapy has been recently approved to be effective for cancer treatment. However, T cells often become dysfunctional after reaching the tumor site. It has been reported that ROS participate extensively in T cells activation, apoptosis, and hyporesponsiveness. The sensitivity of T cells to ROS varies among different subsets. ROS can be regulated by cytokines, amino acid metabolism, and enzymatic activity. Immunosuppressive cells accumulate in the tumor microenvironment and induce apoptosis and functional suppression of T cells by producing ROS. Thus, modulating the level of ROS may be important to prolong survival of T cells and enhance their antitumor function. Combining T cell-based therapy with antioxidant treatment such as administration of ROS scavenger should be considered as a promising strategy in cancer treatment, aiming to improve antitumor T cells immunity.
authors.affiliation: Biotherapy Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, China; Department of Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, China.
authors.forename: Xinfeng
authors.initials: X
authors.lastname: Chen
authors.affiliation: Biotherapy Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, China.
authors.forename: Mengjia
authors.initials: M
authors.lastname: Song
authors.affiliation: Department of Hematology/Oncology, School of Medicine, Northwestern University, Chicago, IL 60201, USA.
authors.forename: Bin
authors.identifier: 0000-0002-6631-7647
authors.initials: B
authors.lastname: Zhang
authors.affiliation: Biotherapy Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, China; Department of Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, China; School of Life Sciences, Zhengzhou University, Zhengzhou, Henan 450052, China; Engineering Key Laboratory for Cell Therapy of Henan Province, Zhengzhou, Henan 450052, China.
authors.forename: Yi
authors.identifier: 0000-0001-9861-4681
authors.initials: Y
authors.lastname: Zhang
mesh_terms: D017209:Apoptosis; D016207:Cytokines / Q000378:metabolism; D006801:Humans; D009369:Neoplasms / Q000276:immunology / Q000378:metabolism / Q000473:pathology; D019001:Nitric Oxide Synthase / Q000378:metabolism; D017382:Reactive Oxygen Species / Q000378:metabolism*; D013601:T-Lymphocytes / Q000166:cytology / Q000276:immunology / Q000378:metabolism*; D059016:Tumor Microenvironment
chemical_list: D016207:Cytokines; D017382:Reactive Oxygen Species; D019001:Nitric Oxide Synthase