title: Transient Receptor Potential Ankyrin 1 (TRPA1) Channel and Neurogenic Inflammation in Pathogenesis of Asthma.
abstract: Asthma is characterized by airway inflammation, airway obstruction, and airway hyperresponsiveness (AHR), and it affects 300 million people worldwide. However, our current understanding of the molecular mechanisms that underlie asthma remains limited. Recent studies have suggested that transient receptor potential ankyrin 1 (TRPA1), one of the transient receptor potential cation channels, may be involved in airway inflammation in asthma. The present review discusses the relationship between TRPA1 and neurogenic inflammation in asthma, hoping to enhance our understanding of the mechanisms of airway inflammation in asthma.
authors.affiliation: Department of Physiology, Dalian Medical University, Dalian, Liaoning, China (mainland).
authors.forename: Hang
authors.initials: H
authors.lastname: Yang
authors.affiliation: Department of Physiology, Dalian Medical University, Dalian, Liaoning, China (mainland).
authors.forename: ShuZhuang
authors.initials: S
authors.lastname: Li
mesh_terms: D001249:Asthma / Q000378:metabolism* / Q000473:pathology*; D015220:Calcium Channels / Q000378:metabolism*; D006801:Humans; D036421:Nerve Fibers, Unmyelinated / Q000378:metabolism / Q000473:pathology; D009419:Nerve Tissue Proteins / Q000378:metabolism*; D020078:Neurogenic Inflammation / Q000378:metabolism* / Q000473:pathology*; D012137:Respiratory System; D000074025:TRPA1 Cation Channel; D050051:Transient Receptor Potential Channels / Q000378:metabolism*
chemical_list: D015220:Calcium Channels; D009419:Nerve Tissue Proteins; D000074025:TRPA1 Cation Channel; C473350:TRPA1 protein, human; D050051:Transient Receptor Potential Channels