title: The Case for Live Attenuated Vaccines against the Neglected Zoonotic Diseases Brucellosis and Bovine Tuberculosis.
abstract: Vaccination of humans and animals with live attenuated organisms has proven to be an effective means of combatting some important infectious diseases. In fact, the 20th century witnessed tremendous improvements in human and animal health worldwide as a consequence of large-scale vaccination programs with live attenuated vaccines (LAVs). Here, we use the neglected zoonotic diseases brucellosis and bovine tuberculosis (BTb) caused by Brucella spp. and Mycobacterium bovis (M. bovis), respectively, as comparative models to outline the merits of LAV platforms with emphasis on molecular strategies that have been pursued to generate LAVs with enhanced vaccine safety and efficacy profiles. Finally, we discuss the prospects of LAV platforms in the fight against brucellosis and BTb and outline new avenues for future research towards developing effective vaccines using LAV platforms.
authors.affiliation: Department of Microbial Pathogenesis and Immunology, Texas A&M Health Science Center, Bryan, Texas, United States of America.|Department of Veterinary Pathobiology, Texas A&M University, College Station, Texas, United States of America.|Norman Borlaug Center, Texas A&M University, College Station, Texas, United States of America.
authors.forename: Aseem
authors.initials: A
authors.lastname: Pandey
authors.affiliation: Department of Veterinary Pathobiology, Texas A&M University, College Station, Texas, United States of America.
authors.forename: Ana
authors.initials: A
authors.lastname: Cabello
authors.affiliation: Department of Veterinary Pathobiology, Texas A&M University, College Station, Texas, United States of America.
authors.forename: Lavoisier
authors.initials: L
authors.lastname: Akoolo
authors.affiliation: Department of Veterinary Pathobiology, Texas A&M University, College Station, Texas, United States of America.|Department of Molecular and Cellular Medicine, Texas A&M Health Science Center, Bryan, Texas, United States of America.
authors.forename: Allison
authors.initials: A
authors.lastname: Rice-Ficht
authors.affiliation: Department of Veterinary Pathobiology, Texas A&M University, College Station, Texas, United States of America.
authors.forename: Angela
authors.initials: A
authors.lastname: Arenas-Gamboa
authors.affiliation: Department of Microbial Pathogenesis and Immunology, Texas A&M Health Science Center, Bryan, Texas, United States of America.
authors.forename: David
authors.initials: D
authors.lastname: McMurray
authors.affiliation: Department of Veterinary Pathobiology, Texas A&M University, College Station, Texas, United States of America.
authors.forename: Thomas A
authors.initials: TA
authors.lastname: Ficht
authors.affiliation: Department of Microbial Pathogenesis and Immunology, Texas A&M Health Science Center, Bryan, Texas, United States of America.|Department of Veterinary Pathobiology, Texas A&M University, College Station, Texas, United States of America.|Norman Borlaug Center, Texas A&M University, College Station, Texas, United States of America.
authors.forename: Paul
authors.initials: P
authors.lastname: de Figueiredo
mesh_terms: D000818:Animals; D002002:Brucella / Q000276:immunology / Q000302:isolation & purification; D002004:Brucella Vaccine / Q000009:adverse effects / Q000276:immunology; D002006:Brucellosis / Q000382:microbiology / Q000517:prevention & control*; D002417:Cattle; D004195:Disease Models, Animal; D006801:Humans; D051379:Mice; D009163:Mycobacterium bovis / Q000276:immunology / Q000302:isolation & purification; D058069:Neglected Diseases / Q000453:epidemiology / Q000382:microbiology / Q000517:prevention & control*; D032581:Tuberculosis Vaccines / Q000008:administration & dosage / Q000276:immunology; D014380:Tuberculosis, Bovine / Q000382:microbiology / Q000517:prevention & control*; D014611:Vaccination / Q000009:adverse effects / Q000379:methods / Q000706:statistics & numerical data / Q000639:trends; D014613:Vaccines, Attenuated / Q000008:administration & dosage / Q000009:adverse effects / Q000276:immunology; D015047:Zoonoses / Q000382:microbiology / Q000517:prevention & control
chemical_list: D002004:Brucella Vaccine; D032581:Tuberculosis Vaccines; D014613:Vaccines, Attenuated