title: Inulin based micelles loaded with curcumin or celecoxib with effective anti-angiogenic activity.
abstract: Curcumin (CUR) and celecoxib (CLX) are two highly hydrophobic drugs which show bioavailability problems due to their poor aqueous solubility. The aim of this study was to encapsulate each of these drugs in micelles based on biodegradable and amphiphilic polymers to investigate their anti-angiogenesis activity. Here we use an amphiphilic polymer, based on two natural substances from renewable resources (Inulin and Vitamin E, INVITE), as a self-assembling system for the drug delivery of CUR and CLX. By the in vivo assay of chick embryo chorioallantoic membrane (CAM) it was assessed that both INVITE-CUR and INVITE-CLX micelles possess remarkable anti-angiogenic activity, while the INVITE micelles alone resulted intrinsically pro-angiogenic. Furthermore, it has been shown that encapsulation of CUR and CLX in INVITE micelles enhances of several magnitudes the water-solubility of CUR and CLX (14·10(5) and 3·10(2) times for CUR and CLX, respectively). These results may have interesting implications not only in anticancer or diabetic maculopathy therapy based on the anti-angiogenesis strategy but also for regenerative medicine where over-production of new vessels is required.
authors.affiliation: Department of Pharmacy, University of Bari "Aldo Moro", Via Orabona 4, 70125 Bari, Italy.
authors.forename: Delia
authors.initials: D
authors.lastname: Mandracchia
authors.affiliation: Department of Drug Sciences, University of Pavia, Viale Taramelli 12, 27100 Pavia, Italy. Electronic address: giuseppe.tripodo@unipv.it.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Tripodo
authors.affiliation: Department of Pharmacy, University of Bari "Aldo Moro", Via Orabona 4, 70125 Bari, Italy.
authors.forename: Adriana
authors.initials: A
authors.lastname: Trapani
authors.affiliation: Department of Basic Medical Sciences, Neurosciences, and Sensory Organs, University of Bari Medical School, Piazza Giulio Cesare 11, 70100 Bari, Italy.
authors.forename: Simona
authors.initials: S
authors.lastname: Ruggieri
authors.affiliation: Department of Basic Medical Sciences, Neurosciences, and Sensory Organs, University of Bari Medical School, Piazza Giulio Cesare 11, 70100 Bari, Italy.
authors.forename: Tiziana
authors.initials: T
authors.lastname: Annese
authors.affiliation: Department of Drug Sciences, University of Pavia, Viale Taramelli 12, 27100 Pavia, Italy.
authors.forename: Theodora
authors.initials: T
authors.lastname: Chlapanidas
authors.affiliation: Department of Pharmacy, University of Bari "Aldo Moro", Via Orabona 4, 70125 Bari, Italy.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Trapani
authors.affiliation: Department of Basic Medical Sciences, Neurosciences, and Sensory Organs, University of Bari Medical School, Piazza Giulio Cesare 11, 70100 Bari, Italy; Cancer Institute "Giovanni Paolo II", 70100 Bari, Italy.
authors.forename: Domenico
authors.initials: D
authors.lastname: Ribatti
mesh_terms: D020533:Angiogenesis Inhibitors / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D000068579:Celecoxib / Q000008:administration & dosage*; D002642:Chick Embryo; D003474:Curcumin / Q000008:administration & dosage*; D007444:Inulin / Q000737:chemistry*; D008823:Micelles
chemical_list: D020533:Angiogenesis Inhibitors; D008823:Micelles; D007444:Inulin; D003474:Curcumin; D000068579:Celecoxib
keywords: Angiogenesis; Celecoxib; Celecoxib (PubChem CID: 2662); Curcumin; Curcumin (PubChem CID: 969516); Inulin; Inulin (PubChem CID: 16219508); Micelle; Vitamin E; Vitamin E (PubChem CID: 14985); Vitamin E Succinate (PubChem CID: 20353)