title: Biosynthesis of silver nanoparticles from Catharanthus roseus leaf extract and assessing their antioxidant, antimicrobial, and wound-healing activities.
abstract: Biosynthesis of silver nanoparticles (AgNPs) from Catharanthus roseus leaf extract was carried out, and their characterization, as well as antioxidant, antimicrobial, and wound-healing activities were evaluated. Color change, UV-vis spectrum, XRD, FTIR, and AFM assessments supported the biosynthesis and characterization of AgNPs. The synthesized AgNPs showed strong in vitro antioxidant and antimicrobial activities against various pathogens. The in vivo assessment of wound healing in AgNPs-treated mice revealed their effectiveness in closuring and reducing size of wounds. Such potent bioactivity may justify their biomedical use as antioxidant and antimicrobial agents for controlling various health-related diseases, particularly in wound healing.
authors.affiliation: a Biology Department, College of Education for Pure Science/Ibn al-Haitham , University of Baghdad , Baghdad , Iraq.
authors.forename: Hanady S A
authors.initials: HSA
authors.lastname: Al-Shmgani
authors.affiliation: b Biotechnology Division, Applied Science Department , University of Technology , Baghdad , Iraq.
authors.forename: Wasnaa H
authors.initials: WH
authors.lastname: Mohammed
authors.affiliation: b Biotechnology Division, Applied Science Department , University of Technology , Baghdad , Iraq.
authors.forename: Ghassan M
authors.initials: GM
authors.lastname: Sulaiman
authors.affiliation: b Biotechnology Division, Applied Science Department , University of Technology , Baghdad , Iraq.
authors.forename: Ali H
authors.initials: AH
authors.lastname: Saadoon
mesh_terms: D000818:Animals; D000890:Anti-Infective Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D000975:Antioxidants / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D002176:Candida albicans / Q000254:growth & development*; D030008:Catharanthus / Q000737:chemistry*; D053768:Metal Nanoparticles / Q000737:chemistry / Q000627:therapeutic use; D051379:Mice; D010936:Plant Extracts / Q000737:chemistry*; D018515:Plant Leaves / Q000737:chemistry*; D012834:Silver / Q000737:chemistry / Q000494:pharmacology; D014945:Wound Healing / Q000187:drug effects*
chemical_list: D000890:Anti-Infective Agents; D000975:Antioxidants; C046419:Catharanthus roseus extract; D010936:Plant Extracts; D012834:Silver
keywords: Silver nanoparticles; antimicrobial; antioxidant; wound healing