title: Metabolic syndrome, obesity, and the risk of cancer development.
abstract: BACKGROUND
  Metabolic syndrome and its components are severe global health issues that are increasing in frequency as the prevalence of obesity increases. Various studies have established a correlation between metabolic syndrome and diseases including, diabetes mellitus, non-alcoholic fatty liver disease, cirrhosis, and cardiovascular disease. In recent years, correlations have also been detected between obesity and metabolic syndrome and the prevalence of certain types of cancer. The current study examines whether obesity and metabolic syndrome components are risk factors for cancer among the adult population in Israel.
  
  
  METHODS
  A cohort study analysis was performed of 24,987 initially healthy men and women who underwent yearly medical assessments at the Institute for Medical Screening in the Sheba Medical Center. Data from the Institute for Medical Screening database was correlated with that from the Israel Cancer Center in the Ministry of Health updated to December 2013. The correlation between metabolic syndrome, obesity, and the overall risk of cancer as well as the risks of specific types of cancer were examined.
  
  
  RESULTS
  Of 20,444 subjects for whom complete data were available, 1535 were diagnosed with cancer during the mean follow-up time of 104.3months. In a multi-variant analysis, no significant correlation was found between metabolic syndrome or obesity and the incidence of cancer. When the data were stratified by gender and cancer type, however, a significant association between metabolic syndrome and breast cancer in women was observed (P=0.03, HR=1.67, 95% CI=1.05-2.67).
  
  
  CONCLUSIONS
  Metabolic syndrome correlates with higher than expected breast cancer incidence in women.
authors.affiliation: The Bert W. Strassburger Lipid Center, Sheba Medical Center, 5265601 Tel Hashomer, Israel; Sackler Faculty of Medicine, Tel-Aviv University, Ramat-Aviv, Israel.
authors.forename: Rafael
authors.initials: R
authors.lastname: Bitzur
authors.affiliation: Sackler Faculty of Medicine, Tel-Aviv University, Ramat-Aviv, Israel; Institute of Oncology, Wolfson Medical Center, Holon, Israel.
authors.forename: Ronen
authors.initials: R
authors.lastname: Brenner
authors.affiliation: Sackler Faculty of Medicine, Tel-Aviv University, Ramat-Aviv, Israel; Leviev Heart Institute, The Chaim Sheba Medical Center, Tel Hashomer, Israel; The Dr. Pinchas Borenstein Talpiot Medical Leadership Program 2013, Sheba Medical Center, Tel Hashomer, Israel.
authors.forename: Elad
authors.initials: E
authors.lastname: Maor
authors.affiliation: Department of Internal Medicine D, The Chaim Sheba Medical Center, Tel Hashomer, Israel.
authors.forename: Maayan
authors.initials: M
authors.lastname: Antebi
authors.affiliation: Department of Epidemiology and Preventive Medicine, School of Public Health, Sackler Faculty of Medicine, Tel-Aviv University, Ramat-Aviv, Israel.
authors.forename: Tomer
authors.initials: T
authors.lastname: Ziv-Baran
authors.affiliation: Institute for Medical Screening, Sheba Medical Center, Israel.
authors.forename: Shlomo
authors.initials: S
authors.lastname: Segev
authors.affiliation: Sackler Faculty of Medicine, Tel-Aviv University, Ramat-Aviv, Israel; Department of Internal Medicine C, The Chaim Sheba Medical Center, Tel Hashomer, Israel.
authors.forename: Yechezkel
authors.initials: Y
authors.lastname: Sidi
authors.affiliation: Sackler Faculty of Medicine, Tel-Aviv University, Ramat-Aviv, Israel; The Dr. Pinchas Borenstein Talpiot Medical Leadership Program 2013, Sheba Medical Center, Tel Hashomer, Israel; Department of Internal Medicine A, The Chaim Sheba Medical Center, Tel Hashomer, Israel. Electronic address: Shai.Kiviti@sheba.health.gov.il.
authors.forename: Shaye
authors.initials: S
authors.lastname: Kivity
mesh_terms: D000328:Adult; D001943:Breast Neoplasms / Q000453:epidemiology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015994:Incidence; D007557:Israel; D008297:Male; D024821:Metabolic Syndrome / Q000453:epidemiology*; D008875:Middle Aged; D015999:Multivariate Analysis; D009765:Obesity / Q000453:epidemiology*; D012189:Retrospective Studies; D012307:Risk Factors; D016019:Survival Analysis
keywords: Breast cancer; Cancer; Metabolic syndrome; Obesity; Overweight