title: Aspecific Uptake of 68GA-PSMA in Paget Disease of the Bone.
abstract: Ga-PSMA plays an increasing role in prostate cancer management, but several instances of false positivity have now been recognized. We present a patient with metastatic prostatic carcinoma who also showed overexpression of PSMA in Paget disease of the humerus on Ga-PSMA PET. This probably relates to bone remodeling and increased vascularity. It is important to be aware of this aspecific uptake because its recognition may avoid overstaging and may alter the therapeutic choice.
authors.affiliation: From the *Department of Nuclear Medicine, Algemeen Ziekenhuis Sint-Jan Brugge-Oostende, Brugge; and †Department of Nuclear Medicine, Universitair Ziekenhuis Brussel, Brussel, Belgium.
authors.forename: Sophie
authors.initials: S
authors.lastname: Bourgeois
authors.forename: Pieterjan
authors.initials: P
authors.lastname: Gykiere
authors.forename: Lode
authors.initials: L
authors.lastname: Goethals
authors.forename: Hendrik
authors.initials: H
authors.lastname: Everaert
authors.forename: Frank W
authors.initials: FW
authors.lastname: De Geeter
mesh_terms: D000230:Adenocarcinoma / Q000150:complications / Q000000981:diagnostic imaging*; D000368:Aged; D004492:Edetic Acid / Q000031:analogs & derivatives; D005709:Gallium Isotopes; D005710:Gallium Radioisotopes; D006801:Humans; D008297:Male; D009842:Oligopeptides; D009942:Organometallic Compounds; D010001:Osteitis Deformans / Q000150:complications / Q000000981:diagnostic imaging*; D000072078:Positron Emission Tomography Computed Tomography; D011471:Prostatic Neoplasms / Q000150:complications / Q000000981:diagnostic imaging*; D019275:Radiopharmaceuticals
chemical_list: D005709:Gallium Isotopes; D005710:Gallium Radioisotopes; D009842:Oligopeptides; D009942:Organometallic Compounds; D019275:Radiopharmaceuticals; C000718244:gallium 68 PSMA-11; D004492:Edetic Acid