title: Celiac Disease and Cystic Fibrosis: Challenges to Differential Diagnosis.
abstract: Cystic fibrosis and celiac disease were considered a single clinical entity for many years. Differentiation between the diseases occurred some time in the 1930s of the 20th Century. Both diseases may present the intestinal malabsorption syndrome and similar clinical manifestations that contribute to difficulties with clinical distinction. We describe a report of two patients with initial diagnosis of cystic fibrosis, who were subsequently diagnosed with celiac disease. These case reports emphasize the possibility of false positivity being shown in the sweat test in CD, which may result in delayed diagnosis and inadequate management of this disease.
authors.affiliation: Department of Pediatric Pulmonology, Universitary Hospital Professor Edgard Santos, Federal University of Bahia (UFBA), Brazil
authors.forename: Alessandra Teixeira Pessoa
authors.initials: AT
authors.lastname: Ramos
authors.affiliation: Department of Pediatric Nutrition, Universitary Hospital Professor Edgard Santos, Federal University of Bahia (UFBA), Brazil
authors.forename: Manuella Machado
authors.initials: MM
authors.lastname: Figueirêdo
authors.affiliation: Department of Pediatric Nutrition, Universitary Hospital Professor Edgard Santos, Federal University of Bahia (UFBA), Brazil
authors.forename: Ana Paula de B
authors.initials: AP
authors.lastname: Aguiar
authors.affiliation: Department of Pediatric Nutrition, Universitary Hospital Professor Edgard Santos, Federal University of Bahia (UFBA), Brazil
authors.forename: Carolina de Godoy
authors.initials: Cde G
authors.lastname: Almeida
authors.affiliation: Department of Pediatric Gastroenterology, Universitary Hospital Professor Edgard Santos, Federal University of Bahia (UFBA),
  Brazil
authors.forename: Patrícia S A
authors.initials: PS
authors.lastname: Mendes
authors.affiliation: Department of Pediatric, School of Medicine of Bahia, Federal University of Bahia, Brazil
authors.forename: Edna Lucia
authors.initials: EL
authors.lastname: Souza
mesh_terms: D002446:Celiac Disease / Q000175:diagnosis* / Q000276:immunology / Q000473:pathology; D002713:Chlorine / Q000032:analysis; D003550:Cystic Fibrosis / Q000175:diagnosis* / Q000473:pathology; D003937:Diagnosis, Differential; D004386:Duodenum / Q000473:pathology*; D016145:Endoscopy, Digestive System; D005189:False Positive Reactions; D005260:Female; D019204:GTP-Binding Proteins / Q000276:immunology; D005903:Gliadin / Q000276:immunology; D006801:Humans; D007223:Infant; D000091345:Protein Glutamine gamma Glutamyltransferase 2; D011502:Protein-Energy Malnutrition; D013542:Sweat / Q000737:chemistry; D011503:Transglutaminases / Q000276:immunology
chemical_list: D002713:Chlorine; D005903:Gliadin; D000091345:Protein Glutamine gamma Glutamyltransferase 2; D011503:Transglutaminases; D019204:GTP-Binding Proteins