title: Selenoprotein P is elevated in individuals with obesity, but is not independently associated with insulin resistance.
abstract: Selenoprotein P (SeP) is secreted primarily by the liver and postulated to cause insulin resistance. The aim of this study was to measure plasma SeP in individuals who are lean (N=29) or overweight/obese (N=34), and examine relationships between circulating SeP, SEPP1 (SeP, plasma 1) expression in subcutaneous adipose tissue, and markers of insulin resistance. SeP was higher in individuals who were overweight/obese (P<0.001), and associated with insulin resistance by HOMA-IR and by clamp, but not independently of BMI. SEPP1 mRNA was correlated negatively with BMI, suggesting there may be tissue specific regulation. This study suggests that obesity, rather than insulin resistance, is central to the increase in SeP.
authors.affiliation: Shanghai First Maternity and Infant Hospital, Tongji University School of Medicine, China; Discipline of Medicine, University of Adelaide, Australia; Research Centre for Reproductive Health, Robinson Research Institute, University of Adelaide, Australia.
authors.forename: Miaoxin
authors.initials: M
authors.lastname: Chen
authors.affiliation: Discipline of Medicine, University of Adelaide, Australia.
authors.forename: Bo
authors.initials: B
authors.lastname: Liu
authors.affiliation: Discipline of Medicine, University of Adelaide, Australia; Discipline of Acute Care Medicine, University of Adelaide, Australia.
authors.forename: David
authors.initials: D
authors.lastname: Wilkinson
authors.affiliation: Discipline of Medicine, University of Adelaide, Australia.
authors.forename: Amy T
authors.initials: AT
authors.lastname: Hutchison
authors.affiliation: Discipline of Medicine, University of Adelaide, Australia.
authors.forename: Campbell H
authors.initials: CH
authors.lastname: Thompson
authors.affiliation: Discipline of Medicine, University of Adelaide, Australia.
authors.forename: Gary A
authors.initials: GA
authors.lastname: Wittert
authors.affiliation: Discipline of Medicine, University of Adelaide, Australia; Research Centre for Reproductive Health, Robinson Research Institute, University of Adelaide, Australia. Electronic address: leonie.heilbronn@adelaide.edu.au.
authors.forename: Leonie K
authors.initials: LK
authors.lastname: Heilbronn
mesh_terms: D000293:Adolescent; D000328:Adult; D001786:Blood Glucose; D002648:Child; D002784:Cholesterol / Q000097:blood; D005260:Female; D006801:Humans; D007333:Insulin Resistance / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000097:blood*; D050177:Overweight / Q000097:blood*; D051149:Selenoprotein P / Q000097:blood*; D055815:Young Adult
chemical_list: D001786:Blood Glucose; D051149:Selenoprotein P; D002784:Cholesterol
keywords: Insulin resistance; Obesity; Selenoprotein P