title: Inflammatory Biomarkers of Birth Asphyxia.
abstract: Although therapies in addition to whole-body cooling are being developed to treat the neonate at risk for hypoxic-ischemic encephalopathy, we have no quickly measured serum inflammatory or neuronal biomarkers to acutely and accurately identify brain injury or to follow the efficacy of therapy. This review covers inflammatory serum biomarkers in the setting of birth asphyxia that can help assess the degree or severity of encephalopathy at birth and neurodevelopmental outcomes. These biomarkers still need to be independently validated in large cohorts before they are ready for clinical implementation in practice.
authors.affiliation: Department of Pediatrics, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Room F3.312B, Dallas, TX 75390-9063, USA. Electronic address: Lina.chalak@utsouthwestern.edu.
authors.forename: Lina F
authors.initials: LF
authors.lastname: Chalak
mesh_terms: D001238:Asphyxia Neonatorum / Q000150:complications / Q000378:metabolism*; D015415:Biomarkers / Q000378:metabolism; D016207:Cytokines / Q000378:metabolism*; D005260:Female; D005904:Glial Fibrillary Acidic Protein / Q000378:metabolism; D006801:Humans; D020925:Hypoxia-Ischemia, Brain / Q000209:etiology / Q000378:metabolism*; D007231:Infant, Newborn; D007249:Inflammation; D010751:Phosphopyruvate Hydratase / Q000378:metabolism; D010920:Placenta / Q000378:metabolism*; D011247:Pregnancy; D064568:S100 Calcium Binding Protein beta Subunit / Q000378:metabolism; D043222:Ubiquitin Thiolesterase / Q000378:metabolism
chemical_list: D015415:Biomarkers; D016207:Cytokines; D005904:Glial Fibrillary Acidic Protein; D064568:S100 Calcium Binding Protein beta Subunit; C579160:S100B protein, human; C507533:Ubiquitin carboxyl-Terminal Hydrolase L-1, human; D043222:Ubiquitin Thiolesterase; D010751:Phosphopyruvate Hydratase
keywords: Asphyxia; Cytokines; GFAP; Placenta; Ubiquitin