title: The Prevalence of Bipolar Disorders and Association With Quality of Life in a Cohort of Patients With Multiple Sclerosis.
abstract: Clinical observations of mood instability in multiple sclerosis (MS) have led to the hypothesis that bipolar disorder (BD) may be more prevalent in persons with MS than in the general population. This cross-sectional study assesses the prevalence of BD among patients with MS using standardized psychiatric diagnostic interviews and evaluates quality of life. This study demonstrates a higher prevalence of BD in patients with MS compared with the general population. It also reveals the negative impact of BD on quality of life, raises the concern that BD can occur before the onset of neurological symptoms in MS, and suggests that, in some cases, BD may delay diagnosis of MS.
authors.affiliation: From the Department of Neurology, University of Massachusetts Medical School, Worcester, Mass (AJ-O, IBM, NH); the Department of Neurology, Johns Hopkins Medical School, Baltimore (AB); the Department of Psychiatry, Center for Psychopharmacologic Research and Treatment, University of Massachusetts Medical School, Worcester, Mass (KMD); the Department of Psychiatry, University of Massachusetts Medical School, Worcester, Mass (NB);and the Department of Neurology, University of Massachusetts Memorial Medical Center, Worcester, Mass. (CI).
authors.forename: Adalia H
authors.initials: AH
authors.lastname: Jun-O'Connell
authors.affiliation: From the Department of Neurology, University of Massachusetts Medical School, Worcester, Mass (AJ-O, IBM, NH); the Department of Neurology, Johns Hopkins Medical School, Baltimore (AB); the Department of Psychiatry, Center for Psychopharmacologic Research and Treatment, University of Massachusetts Medical School, Worcester, Mass (KMD); the Department of Psychiatry, University of Massachusetts Medical School, Worcester, Mass (NB);and the Department of Neurology, University of Massachusetts Memorial Medical Center, Worcester, Mass. (CI).
authors.forename: Ankur
authors.initials: A
authors.lastname: Butala
authors.affiliation: From the Department of Neurology, University of Massachusetts Medical School, Worcester, Mass (AJ-O, IBM, NH); the Department of Neurology, Johns Hopkins Medical School, Baltimore (AB); the Department of Psychiatry, Center for Psychopharmacologic Research and Treatment, University of Massachusetts Medical School, Worcester, Mass (KMD); the Department of Psychiatry, University of Massachusetts Medical School, Worcester, Mass (NB);and the Department of Neurology, University of Massachusetts Memorial Medical Center, Worcester, Mass. (CI).
authors.forename: Idanis Berrios
authors.initials: IB
authors.lastname: Morales
authors.affiliation: From the Department of Neurology, University of Massachusetts Medical School, Worcester, Mass (AJ-O, IBM, NH); the Department of Neurology, Johns Hopkins Medical School, Baltimore (AB); the Department of Psychiatry, Center for Psychopharmacologic Research and Treatment, University of Massachusetts Medical School, Worcester, Mass (KMD); the Department of Psychiatry, University of Massachusetts Medical School, Worcester, Mass (NB);and the Department of Neurology, University of Massachusetts Memorial Medical Center, Worcester, Mass. (CI).
authors.forename: Nils
authors.initials: N
authors.lastname: Henninger
authors.affiliation: From the Department of Neurology, University of Massachusetts Medical School, Worcester, Mass (AJ-O, IBM, NH); the Department of Neurology, Johns Hopkins Medical School, Baltimore (AB); the Department of Psychiatry, Center for Psychopharmacologic Research and Treatment, University of Massachusetts Medical School, Worcester, Mass (KMD); the Department of Psychiatry, University of Massachusetts Medical School, Worcester, Mass (NB);and the Department of Neurology, University of Massachusetts Memorial Medical Center, Worcester, Mass. (CI).
authors.forename: Kristina M
authors.initials: KM
authors.lastname: Deligiannidis
authors.affiliation: From the Department of Neurology, University of Massachusetts Medical School, Worcester, Mass (AJ-O, IBM, NH); the Department of Neurology, Johns Hopkins Medical School, Baltimore (AB); the Department of Psychiatry, Center for Psychopharmacologic Research and Treatment, University of Massachusetts Medical School, Worcester, Mass (KMD); the Department of Psychiatry, University of Massachusetts Medical School, Worcester, Mass (NB);and the Department of Neurology, University of Massachusetts Memorial Medical Center, Worcester, Mass. (CI).
authors.forename: Nancy
authors.initials: N
authors.lastname: Byatt
authors.affiliation: From the Department of Neurology, University of Massachusetts Medical School, Worcester, Mass (AJ-O, IBM, NH); the Department of Neurology, Johns Hopkins Medical School, Baltimore (AB); the Department of Psychiatry, Center for Psychopharmacologic Research and Treatment, University of Massachusetts Medical School, Worcester, Mass (KMD); the Department of Psychiatry, University of Massachusetts Medical School, Worcester, Mass (NB);and the Department of Neurology, University of Massachusetts Memorial Medical Center, Worcester, Mass. (CI).
authors.forename: Carolina
authors.initials: C
authors.lastname: Ionete
mesh_terms: D000328:Adult; D001714:Bipolar Disorder / Q000150:complications / Q000453:epidemiology* / Q000523:psychology; D015331:Cohort Studies; D015897:Comorbidity; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D007406:Interview, Psychological; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000150:complications / Q000453:epidemiology* / Q000523:psychology; D015995:Prevalence; D011788:Quality of Life; D057566:Self Report; D062606:Tertiary Care Centers