title: LncRNAs act as prognostic and diagnostic biomarkers in renal cell carcinoma: a systematic review and meta-analysis.
abstract: We conducted a systematic review and meta-analysis to investigate the clinical values, including clinicopathology, prognosis, and diagnosis of different long non-coding RNAs (lncRNAs) in renal cell carcinoma (RCC). A total of 14 eligible studies, including 10 on clinicopathological features, 11 on prognosis, and 3 on diagnosis were identified. Results revealed that metastasis-associated lung adenocarcinoma transcript 1(MALAT1) expression was associated with tumor stage (odds ratio [OR], 3.46; 95% confidence interval [CI], 1.63-7.36; p=0.001). The high expression of MALAT1 could be considered a biomarker of the early detection of lymph node metastasis and predictor of poor survival in RCC patients, who likely manifested short overall survival (OS; hazard ratio [HR], 2.97; 95% CI, 1.68-5.28; p<0.001). For diagnostic value, the pooled result showed that lncRNA maintained a sensitivity of 0.89 and specificity of 0.91 in RCC diagnosis, The area under the curve of 0.94 (95% CI, 0.92-0.96) for lncRNA in RCC diagnosis also indicated a significant advantage over other biomarkers. Our systematic review and meta-analysis demonstrated that lncRNAs could be considered biomarkers to detect lymph node metastasis and distant metastasis in early stages. LncRNAs could function as potential prognostic markers in RCC. LncRNAs could also display high accuracy for RCC diagnosis.
authors.affiliation: Department of Urology/State Key Laboratory of Kidney Diseases, Chinese People's Liberation Army General Hospital, Beijing, China.
authors.forename: Jianwen
authors.initials: J
authors.lastname: Chen
authors.affiliation: Department of Cardiology, Beijing Anzhen Hospital affiliated to Capital Medical University, Beijing, China.
authors.forename: Yalei
authors.initials: Y
authors.lastname: Chen
authors.affiliation: Department of Urology/State Key Laboratory of Kidney Diseases, Chinese People's Liberation Army General Hospital, Beijing, China.
authors.forename: Liangyou
authors.initials: L
authors.lastname: Gu
authors.affiliation: Department of Urology/State Key Laboratory of Kidney Diseases, Chinese People's Liberation Army General Hospital, Beijing, China.
authors.forename: Xintao
authors.initials: X
authors.lastname: Li
authors.affiliation: Department of Urology/State Key Laboratory of Kidney Diseases, Chinese People's Liberation Army General Hospital, Beijing, China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Gao
authors.affiliation: Department of Urology/State Key Laboratory of Kidney Diseases, Chinese People's Liberation Army General Hospital, Beijing, China.
authors.forename: Xiangjun
authors.initials: X
authors.lastname: Lyu
authors.affiliation: Department of Urology/State Key Laboratory of Kidney Diseases, Chinese People's Liberation Army General Hospital, Beijing, China.
authors.forename: Luyao
authors.initials: L
authors.lastname: Chen
authors.affiliation: Department of Urology/State Key Laboratory of Kidney Diseases, Chinese People's Liberation Army General Hospital, Beijing, China.
authors.forename: Guoxiong
authors.initials: G
authors.lastname: Luo
authors.affiliation: Department of Urology/State Key Laboratory of Kidney Diseases, Chinese People's Liberation Army General Hospital, Beijing, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Wang
authors.affiliation: Department of Urology/State Key Laboratory of Kidney Diseases, Chinese People's Liberation Army General Hospital, Beijing, China.
authors.forename: Yongpeng
authors.initials: Y
authors.lastname: Xie
authors.affiliation: Department of Urology/State Key Laboratory of Kidney Diseases, Chinese People's Liberation Army General Hospital, Beijing, China.
authors.forename: Junyao
authors.initials: J
authors.lastname: Duan
authors.affiliation: Department of Urology/State Key Laboratory of Kidney Diseases, Chinese People's Liberation Army General Hospital, Beijing, China.
authors.forename: Cheng
authors.initials: C
authors.lastname: Peng
authors.affiliation: Department of Urology/State Key Laboratory of Kidney Diseases, Chinese People's Liberation Army General Hospital, Beijing, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Ma
mesh_terms: D014408:Biomarkers, Tumor / Q000235:genetics*; D002292:Carcinoma, Renal Cell / Q000235:genetics* / Q000473:pathology; D006801:Humans; D007680:Kidney Neoplasms / Q000235:genetics*; D011379:Prognosis; D062085:RNA, Long Noncoding / Q000235:genetics*
chemical_list: D014408:Biomarkers, Tumor; D062085:RNA, Long Noncoding
keywords: clinicopathology; diagnosis; lncRNA; prognosis; renal cell carcinoma