title: Optimal initial state for fast parameter estimation in nonlinear dynamical systems.
abstract: OBJECTIVE
  This paper deals with the improvement of parameter estimation in terms of precision and computational time for dynamical models in a bounded error context.
  
  
  METHODS
  To improve parameter estimation, an optimal initial state design is proposed combined with a contractor. This contractor is based on a volumetric criterion and an original condition initializing this contractor is given. Based on a sensitivity analysis, our optimal initial state design methodology consists in searching the minimum value of a proposed criterion for the interested parameters. In our framework, the uncertainty (on measurement noise and parameters) is supposed unknown but belongs to known bounded intervals. Thus guaranteed state and sensitivity estimation have been considered. An elementary effect analysis on the number of sampling times is also implemented to achieve the fast and guaranteed parameter estimation.
  
  
  RESULTS
  The whole procedure is applied to a pharmacokinetics model and simulation results are given.
  
  
  CONCLUSIONS
  The good improvement of parameter estimation in terms of computational time and precision for the case study highlights the potential of the proposed methodology.
authors.affiliation: Compiègne Technology University, Rue du Docteur Schweitzer, Compiègne, France.
authors.forename: Qiaochu
authors.initials: Q
authors.lastname: Li
authors.affiliation: LAAS-CNRS, Université de Toulouse, UPS, 7 Avenue du colonel Roche, Toulouse, France.
authors.forename: Carine
authors.initials: C
authors.lastname: Jauberthie
authors.affiliation: Compiègne Technology University, Rue du Docteur Schweitzer, Compiègne, France. Electronic address: lilianne.denis-vidal@utc.fr.
authors.forename: Lilianne
authors.initials: L
authors.lastname: Denis-Vidal
authors.affiliation: Compiègne Technology University, Rue du Docteur Schweitzer, Compiègne, France.
authors.forename: Zohra
authors.initials: Z
authors.lastname: Cherfi
mesh_terms: D000465:Algorithms; D003198:Computer Simulation; D005949:Glucose Oxidase / Q000493:pharmacokinetics; D008954:Models, Biological; D017711:Nonlinear Dynamics
chemical_list: D005949:Glucose Oxidase
keywords: Bounded noise; Contractor; Interval analysis; Nonlinear systems; Optimal initial state; Parameter estimation