title: Hypoxia and Neonatal Haemorrhagic Stroke: Experimental Study of Mechanisms.
abstract: We studied the level of blood oxygen saturation (SpO2) in the brain in newborn rats in the pre- and post-stroke periods, as well as the changes in cerebral blood flow and beta-arrestin-1 as a marker of hypoxic stress. Our results show that mild hypoxia precedes the stroke development and is associated with venous relaxation and decrease blood outflow from the brain resulting in the elevation of synthesis of beta-arrestin-1 in the brain. The incidence of stroke is characterized by severe hypoxia, which is accompanied by the progression of pathological changes in cerebral veins and the high level of beta-arrestin-1.
authors.affiliation: Saratov State University, Astrakhanskaya Str. 83, Saratov, 410012, Russia. glushkovskaya@mail.ru.|Britton Chance Center for Biomedical Photonics, Huazhong University of Science and Technology, Wuhan, 430074, China. glushkovskaya@mail.ru.
authors.forename: Oxana
authors.initials: O
authors.lastname: Semyachkina-Glushkovskaya
authors.affiliation: Institute of Electronics, Bulgarian Academy of Sciences, Tsarigradsko Chaussee 72, Sofia, 1784, Bulgaria.
authors.forename: Ekaterina
authors.initials: E
authors.lastname: Borisova
authors.affiliation: Saratov State University, Astrakhanskaya Str. 83, Saratov, 410012, Russia.
authors.forename: Anton
authors.initials: A
authors.lastname: Namikin
authors.affiliation: Saratov State University, Astrakhanskaya Str. 83, Saratov, 410012, Russia.
authors.forename: Ivan
authors.initials: I
authors.lastname: Fedosov
authors.affiliation: Saratov State University, Astrakhanskaya Str. 83, Saratov, 410012, Russia.
authors.forename: Arkady
authors.initials: A
authors.lastname: Abdurashitov
authors.affiliation: Saratov State University, Astrakhanskaya Str. 83, Saratov, 410012, Russia.
authors.forename: Ekaterina
authors.initials: E
authors.lastname: Zhinchenko
authors.affiliation: Saratov State University, Astrakhanskaya Str. 83, Saratov, 410012, Russia.
authors.forename: Artem
authors.initials: A
authors.lastname: Gekalyuk
authors.affiliation: Saratov State University, Astrakhanskaya Str. 83, Saratov, 410012, Russia.
authors.forename: Maria
authors.initials: M
authors.lastname: Ulanova
authors.affiliation: Saratov State University, Astrakhanskaya Str. 83, Saratov, 410012, Russia.
authors.forename: Victoria
authors.initials: V
authors.lastname: Rezunbaeva
authors.affiliation: Institute of Electronics, Bulgarian Academy of Sciences, Tsarigradsko Chaussee 72, Sofia, 1784, Bulgaria.
authors.forename: Latchezar
authors.initials: L
authors.lastname: Avramov
authors.affiliation: Britton Chance Center for Biomedical Photonics, Huazhong University of Science and Technology, Wuhan, 430074, China.
authors.forename: Dan
authors.initials: D
authors.lastname: Zhu
authors.affiliation: Britton Chance Center for Biomedical Photonics, Wuhan National Laboratory for Optoelectronics, Huazhong University of Science and Technology, Wuhan, 430074, China.
authors.forename: Qingming
authors.initials: Q
authors.lastname: Luo
authors.affiliation: Saratov State University, Astrakhanskaya Str. 83, Saratov, 410012, Russia.|Britton Chance Center for Biomedical Photonics, Huazhong University of Science and Technology, Wuhan, 430074, China.|Laboratory of Biophotonics, Tomsk State University, Tomsk, 634050, Russia.
authors.forename: Valery
authors.initials: V
authors.lastname: Tuchin
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D015415:Biomarkers / Q000097:blood; D001921:Brain / Q000098:blood supply* / Q000378:metabolism*; D015687:Cell Hypoxia; D002550:Cerebral Veins / Q000378:metabolism / Q000503:physiopathology; D002560:Cerebrovascular Circulation; D004195:Disease Models, Animal; D000860:Hypoxia / Q000097:blood* / Q000503:physiopathology; D020300:Intracranial Hemorrhages / Q000097:blood* / Q000503:physiopathology; D010100:Oxygen / Q000097:blood*; D010101:Oxygen Consumption; D051381:Rats; D020521:Stroke / Q000097:blood* / Q000503:physiopathology; D013997:Time Factors; D015854:Up-Regulation; D014664:Vasodilation; D000071559:beta-Arrestin 1 / Q000378:metabolism
chemical_list: C000605256:Arrb1 protein, rat; D015415:Biomarkers; D000071559:beta-Arrestin 1; D010100:Oxygen
keywords: Beta-arrestin-1; Cerebral blood flow; Hypoxia; Neonatal haemorrhagic stroke