title: Epidemiological profile and risk factors of HIV and HBV/HCV co-infection in Fujian Province, southeastern China.
abstract: This study aimed to investigate the epidemiological features of HIV-infected subjects co-infected with HBV/HCV in Fujian Province, southeastern China, and identify the risk factors. Blood samples were collected from 2,028 HIV antibody-positive subjects in Fujian Province. Serum HBsAg and anti-HCV antibody were detected, and CD4+T cell count was measured. Of the 2,028 subjects, the prevalence of HIV-HBV, HIV-HCV, and HIV-HBV-HCV co-infections was 16.22%, 3.7%, and 0.79%, respectively. Man (OR = 1.912, 95% CI: 1.371-2.667), key population (OR = 0.756, 95% CI: 0.57-0.976) and detainee (OR = 0.486, 95% CI: 0.259-0.909) were risk factors of HIV-HBV co-infection, and man (OR = 2.227, 95% CI: 1.096-4.525), minority (OR = 5.04, 95% CI: 1.696-14.98), junior high school or lower education (OR = 2.32, 95% CI: 1.071-5.025), intravenous drug use (OR = 38.46, 95% CI: 11.46-129.11) and detainee (OR = 5.687, 95% CI: 2.44-13.25) were risk factors of HIV-HCV co-infection. In addition, a lower mean CD4+T cell count was measured in HIV/HBV and HIV/HCV co-infected subjects than in HIV-infected subjects among the untreated individuals, while in the treated populations, a higher mean CD4+T cell count was detected in HIV/HBV and HIV/HCV co-infected subjects than in HIV-infected subjects. HIV co-infection with HBV or HCV, notably HIV-HBV co-infection, is widespread in southeastern China. Hepatitis virus screening should be included in monitoring of HIV infection, and HIV and hepatitis virus co-infection should be considered during the development of HIV antiretroviral therapy scheme. J. Med. Virol. 89:443-449, 2017. © 2016 Wiley Periodicals, Inc.
authors.affiliation: Fujian Provincial Center for Disease Control and Prevention, Fuzhou City, Fujian Province, China.|Fujian Provincial Key Laboratory of Zoonosis Research, Fuzhou City, Fujian Province, China.|School of Public Health, Fujian Medical University, Fuzhou City, Fujian Province, China.
authors.forename: Shouli
authors.initials: S
authors.lastname: Wu
authors.affiliation: Fujian Provincial Center for Disease Control and Prevention, Fuzhou City, Fujian Province, China.|Fujian Provincial Key Laboratory of Zoonosis Research, Fuzhou City, Fujian Province, China.|School of Public Health, Fujian Medical University, Fuzhou City, Fujian Province, China.
authors.forename: Pingping
authors.initials: P
authors.lastname: Yan
authors.affiliation: School of Public Health, Fujian Medical University, Fuzhou City, Fujian Province, China.
authors.forename: Tianfei
authors.initials: T
authors.lastname: Yang
authors.affiliation: Fujian Provincial Center for Disease Control and Prevention, Fuzhou City, Fujian Province, China.|Fujian Provincial Key Laboratory of Zoonosis Research, Fuzhou City, Fujian Province, China.
authors.forename: Zhenghua
authors.initials: Z
authors.lastname: Wang
authors.affiliation: Fujian Provincial Center for Disease Control and Prevention, Fuzhou City, Fujian Province, China.|Fujian Provincial Key Laboratory of Zoonosis Research, Fuzhou City, Fujian Province, China.|School of Public Health, Fujian Medical University, Fuzhou City, Fujian Province, China.
authors.forename: Yansheng
authors.initials: Y
authors.lastname: Yan
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D018791:CD4 Lymphocyte Count; D002648:Child; D002675:Child, Preschool; D002681:China / Q000453:epidemiology; D060085:Coinfection / Q000453:epidemiology*; D003710:Demography; D005260:Female; D015658:HIV Infections / Q000150:complications*; D006514:Hepatitis B Surface Antigens / Q000097:blood; D019694:Hepatitis B, Chronic / Q000453:epidemiology*; D018937:Hepatitis C Antibodies / Q000097:blood; D019698:Hepatitis C, Chronic / Q000453:epidemiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D012307:Risk Factors; D055815:Young Adult
chemical_list: D006514:Hepatitis B Surface Antigens; D018937:Hepatitis C Antibodies
keywords: HBV; HCV; HIV; Southeastern China; co-infection; risk factor