title: Host environmental signals and effects on biofilm formation.
abstract: Biofilm matrix formation is a phenotype linked to the ability to survive a hostile host environment that includes the presence of antimicrobial peptides and serum factors. Multiple hormones and other host derived factors have been shown to function as exogenous quorum signaling compound homologs that inform microbes of their in situ presence, thus triggering a shift from a planktonic to the sessile biofilm phenotype. The focus of this review is to describe the impact various host-derived factors have on the initial steps required for biofilm formation, i.e., adherence to host surfaces and multiplication in the host.
authors.affiliation: Department of Microbiology and Immunology, Chicago College of Osteopathic Medicine, Midwestern University, Downers Grove, IL 60515, USA.
authors.forename: Dana
authors.initials: D
authors.lastname: Feraco
authors.affiliation: Department of Microbiology and Immunology, Chicago College of Osteopathic Medicine, Midwestern University, Downers Grove, IL 60515, USA.
authors.forename: Mary
authors.initials: M
authors.lastname: Blaha
authors.affiliation: Department of Microbiology and Immunology, Chicago College of Osteopathic Medicine, Midwestern University, Downers Grove, IL 60515, USA.
authors.forename: Shaza
authors.initials: S
authors.lastname: Khan
authors.affiliation: Department of Biochemistry, Chicago College of Osteopathic Medicine, Midwestern University, Downers Grove, IL 60515, USA.
authors.forename: Jacalyn M
authors.initials: JM
authors.lastname: Green
authors.affiliation: Department of Microbiology and Immunology, Chicago College of Osteopathic Medicine, Midwestern University, Downers Grove, IL 60515, USA. Electronic address: bplotk@midwestern.edu.
authors.forename: Balbina J
authors.initials: BJ
authors.lastname: Plotkin
mesh_terms: D000818:Animals; D018407:Bacterial Physiological Phenomena; D018441:Biofilms / Q000254:growth & development*; D005658:Fungi / Q000502:physiology*; D054884:Host-Pathogen Interactions; D006801:Humans; D053038:Quorum Sensing / Q000187:drug effects
keywords: Biofilm; Candida albicans; Catecholamine; Catheter-associated infections; Dehydroepiandosterone (DHEA); Escherichia coli; Estrogen; Insulin; Progesterone; Quorum compounds; Staphylococcus aureus; Vitamin K