title: Feeling Worn Out? PGC1α to the Rescue for Dysfunctional Mitochondria in T Cell Exhaustion.
abstract: In chronic viral infections and cancer, T cells acquire a functional state characterized by reduced effector functionality, termed exhaustion. In two related studies by Scharping et al. (2016) and Bengsch et al. (2016) in this issue of Immunity, dysfunctional mitochondria are identified as a key correlate of CD8(+) T cell exhaustion.
authors.affiliation: Department of Biomedicine, Immunobiology, University and University Hospital Basel, 4031 Basel, Switzerland.
authors.forename: Maria L
authors.initials: ML
authors.lastname: Balmer
authors.affiliation: Department of Biomedicine, Immunobiology, University and University Hospital Basel, 4031 Basel, Switzerland. Electronic address: chess@uhbs.ch.
authors.forename: Christoph
authors.initials: C
authors.lastname: Hess
mesh_terms: D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D004644:Emotions; D006801:Humans; D008928:Mitochondria; D014157:Transcription Factors; D014777:Virus Diseases / Q000276:immunology
chemical_list: D014157:Transcription Factors