title: Two New Steroidal Aglycones from Roots of Cynanchun paniculatum.
abstract: Two new 13, 14/14, 15-disecopregnane-type skeleton C21 steroidal aglycones, neocynapanogenin G (1) and neocynapanogenin H (2), were isolated from the hydrolyzed extract of the CHCl3 soluble extract of the roots of Cynanchun paniculatum. Their structures were determined on the basis of chemical evidence and extensive spectroscopic methods, including 1D and 2D NMR spectroscopy. Compound 1 displayed signifidant inhibition of the Hedgehog signaling pathway in vitro.
authors.forename: Jia-Wen
authors.initials: JW
authors.lastname: Zhao
authors.forename: Feng-Yang
authors.initials: FY
authors.lastname: Chen
authors.forename: Li-Juan
authors.initials: LJ
authors.lastname: Gao
authors.forename: Shi-Fang
authors.initials: SF
authors.lastname: Xu
authors.forename: Yi-Ping
authors.initials: YP
authors.lastname: Ye
authors.forename: Xiao-Yu
authors.initials: XY
authors.lastname: Li
mesh_terms: D000818:Animals; D002460:Cell Line; D031105:Cynanchum / Q000737:chemistry*; D004365:Drugs, Chinese Herbal / Q000737:chemistry*; D006364:Hedgehogs / Q000235:genetics / Q000378:metabolism; D006801:Humans; D039823:Iridoids / Q000737:chemistry*; D015394:Molecular Structure; D018517:Plant Roots / Q000737:chemistry*; D015398:Signal Transduction / Q000187:drug effects; D013256:Steroids / Q000737:chemistry*
chemical_list: D004365:Drugs, Chinese Herbal; D039823:Iridoids; D013256:Steroids