title: Variation in treatment and outcome in the early stage oral cavity squamous cell carcinoma.
abstract: This study aims to determine the survival impact of patient characteristics and treatment options associated with the early stage oral cavity squamous cell carcinoma, OCSCC. The methods are analysis of Irish cancer database examining T1/2, N0, and M0 cases of OCSCC from 1997 to 2007 inclusive. In total, 397 cases were identified. Anterolateral tongue accounted for 52.9 % of cases. Increased age at diagnosis and smoking are independent prognostic survival indicators associated with poorer outcomes. Surgery as the initial intervention was associated with significantly better survival outcomes, while surgery and adjuvant radiotherapy significantly worse outcomes. Surgical intervention is recommended as the first-line treatment in the early stage OCSCC in combination with elective neck dissection.
authors.affiliation: Anaesthesia, St. Vincent's University Hospital, Dublin 4, Ireland. gogartyd@gmail.com.|RCSI Otolaryngology, Head and Neck Surgery, RCSI Education and Research Centre, Beaumont Hospital, Beaumont, Dublin 9, Ireland. gogartyd@gmail.com.
authors.forename: Darragh S
authors.initials: DS
authors.lastname: Gogarty
authors.affiliation: Department of Otolaryngology, Head and Neck Surgery, The Royal College of Surgeons in Ireland, 123 St. Stephens Green, Dublin 2, Ireland.
authors.forename: Paul
authors.initials: P
authors.lastname: Lennon
authors.affiliation: National Cancer Registry Ireland, Building 6800, Cork Airport Business Pk., Kinsale Road, Cork, Ireland.
authors.forename: Sandra
authors.initials: S
authors.lastname: Deady
authors.affiliation: Beaumont Hospital, Beaumont Road, Dublin 9, Ireland.
authors.forename: J
authors.initials: J
authors.lastname: Barry O'Sullivan
authors.affiliation: St. Luke's Oncology Network, Beaumont Hospital, Beaumont Road, Dublin 9, Ireland.
authors.forename: Orla
authors.initials: O
authors.lastname: McArdle
authors.affiliation: Department of Pathology, The Royal College of Surgeons in Ireland, 123 St. Stephens Green, Dublin 2, Ireland.
authors.forename: Mary
authors.initials: M
authors.lastname: Leader
authors.affiliation: South Infirmary Victoria University Hospital, Cork, Ireland.
authors.forename: Patrick
authors.initials: P
authors.lastname: Sheahan
authors.affiliation: Department of Otolaryngology, Head and Neck Surgery, The Royal College of Surgeons in Ireland, 123 St. Stephens Green, Dublin 2, Ireland.
authors.forename: James Paul
authors.initials: JP
authors.lastname: O'Neill
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000401:mortality / Q000473:pathology / Q000628:therapy*; D016208:Databases, Factual; D017558:Elective Surgical Procedures; D005260:Female; D006801:Humans; D007494:Ireland; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000401:mortality / Q000473:pathology / Q000628:therapy*; D037981:Neck Dissection; D009367:Neoplasm Staging; D011379:Prognosis; D018714:Radiotherapy, Adjuvant; D012189:Retrospective Studies; D012907:Smoking; D016896:Treatment Outcome
keywords: Adult; Node negative; Oral cavity; Radiotherapy; Survival