title: Somatic Genome Editing Goes Viral.
abstract: Generating new mouse models of cancer is a challenging and laborious task that can require years of investment to interrogate a single gene. Now, Jonkers and colleagues describe the first application of CRISPR-based genome editing in the mammary gland, providing a new approach to dissect complex genetic interactions in vivo.
authors.affiliation: Sandra and Edward Meyer Cancer Center, Department of Medicine, Division of Hematology and Medical Oncology, Weill Cornell Medicine, New York, NY 10021, USA.
authors.forename: Maria Paz
authors.initials: MP
authors.lastname: Zafra
authors.affiliation: Sandra and Edward Meyer Cancer Center, Department of Medicine, Division of Hematology and Medical Oncology, Weill Cornell Medicine, New York, NY 10021, USA. Electronic address: lud2005@med.cornell.edu.
authors.forename: Lukas E
authors.initials: LE
authors.lastname: Dow
mesh_terms: D000818:Animals; D001940:Breast / Q000378:metabolism; D001943:Breast Neoplasms / Q000235:genetics; D064113:CRISPR-Cas Systems; D064112:Clustered Regularly Interspaced Short Palindromic Repeats; D004195:Disease Models, Animal; D005260:Female; D000072669:Gene Editing / Q000379:methods*; D016678:Genome; D006801:Humans; D051379:Mice