title: Biosynthesis, remodeling and turnover of mitochondrial cardiolipin.
abstract: Among mitochondrial lipids, cardiolipin occupies a unique place. It is the only phospholipid that is specific to mitochondria and although it is merely a minor component, accounting for 10-20% of the total phospholipid content, cardiolipin plays an important role in the molecular organization, and thus the function of the cristae. This review covers the formation of cardiolipin, a phospholipid dimer containing two phosphatidyl residues, and its assembly into mitochondrial membranes. While a large body of literature exists on this topic, the review focuses on papers that appeared in the past three years. This article is part of a Special Issue entitled: Lipids of Mitochondria edited by Guenther Daum.
authors.affiliation: Department of Anesthesiology and Cell Biology, New York University School of Medicine, New York, NY 10016, USA. Electronic address: michael.schlame@med.nyu.edu.
authors.forename: Michael
authors.initials: M
authors.lastname: Schlame
authors.affiliation: Department of Biological Sciences, Wayne State University, Detroit, MI 48202, USA.
authors.forename: Miriam L
authors.initials: ML
authors.lastname: Greenberg
mesh_terms: D000818:Animals; D002308:Cardiolipins / Q000378:metabolism*; D006801:Humans; D008928:Mitochondria / Q000378:metabolism*; D051336:Mitochondrial Membranes / Q000378:metabolism; D010743:Phospholipids / Q000378:metabolism; D014176:Protein Biosynthesis / Q000502:physiology*
chemical_list: D002308:Cardiolipins; D010743:Phospholipids
keywords: Lipids; Membrane assembly; Metabolism; Mitochondria