title: The metabolomic signature of hematologic malignancies.
abstract: The ongoing accumulation of knowledge raises hopes that understanding tumor metabolism will provide new ways for predicting, diagnosing, and even treating cancers. Some metabolic biomarkers are at present routinely utilized to diagnose cancer and metabolic alterations of tumors are being confirmed as therapeutic targets. The growing utilization of metabolomics in clinical research may rapidly turn it into one of the most potent instruments used to detect and fight tumor. In fact, while the current state and trends of high throughput metabolomics profiling focus on the purpose of discovering biomarkers and hunting for metabolic mechanism, a prospective direction, namely reprogramming metabolomics, highlights the way to use metabolomics approach for the aim of treatment of disease by way of reconstruction of disturbed metabolic pathways. In this review, we present an ample summary of the current clinical appliances of metabolomics in hematological malignancies.
authors.affiliation: Dipartimento di Patologia Umana dell'Adulto e dell'Età Evolutiva "Gaetano Barresi", University of Messina, Via Consolare Valeria, 1, 98125 Messina, Italy. Electronic address: aallegra@unime.it.
authors.forename: Alessandro
authors.initials: A
authors.lastname: Allegra
authors.affiliation: Dipartimento di Patologia Umana dell'Adulto e dell'Età Evolutiva "Gaetano Barresi", University of Messina, Via Consolare Valeria, 1, 98125 Messina, Italy.
authors.forename: Vanessa
authors.initials: V
authors.lastname: Innao
authors.affiliation: Dipartimento di Patologia Umana dell'Adulto e dell'Età Evolutiva "Gaetano Barresi", University of Messina, Via Consolare Valeria, 1, 98125 Messina, Italy.
authors.forename: Demetrio
authors.initials: D
authors.lastname: Gerace
authors.affiliation: Dipartimento di Patologia Umana dell'Adulto e dell'Età Evolutiva "Gaetano Barresi", University of Messina, Via Consolare Valeria, 1, 98125 Messina, Italy.
authors.forename: Oriana
authors.initials: O
authors.lastname: Bianco
authors.affiliation: Dipartimento di Patologia Umana dell'Adulto e dell'Età Evolutiva "Gaetano Barresi", University of Messina, Via Consolare Valeria, 1, 98125 Messina, Italy.
authors.forename: Caterina
authors.initials: C
authors.lastname: Musolino
mesh_terms: D035843:Biomedical Research; D055808:Drug Discovery; D019337:Hematologic Neoplasms / Q000188:drug therapy* / Q000378:metabolism; D006801:Humans; D053858:Metabolic Networks and Pathways / Q000187:drug effects; D055432:Metabolomics / Q000379:methods* / Q000639:trends
keywords: Biomarkers; Cancer; Chemoresistance; Hematological malignancies; Metabolomics; Warburg effect