title: Chemoselective Layer-by-Layer Approach Utilizing Click Reactions with Ethynylcyclooctynes and Diazides.
abstract: Ethynylcyclooctynes and diazides were synthesized and applied for a chemoselective sequence of copper(I)-catalyzed azide-alkyne cycloadditions and strain-promoted azide-alkyne cycloadditions. Chemoselectivity within the reaction sequence was achieved by balancing three factors: Cu-catalysis/ring strain/steric shielding. A cholic acid derived triazide was subjected to the cycloaddition sequence as a model system for a layer-by-layer synthesis on surfaces.
authors.affiliation: Fachbereich Chemie, Philipps-University Marburg , Hans-Meerwein-Strasse 4, D-35043 Marburg, Germany.
authors.forename: Niels
authors.initials: N
authors.lastname: Münster
authors.affiliation: Fachbereich Chemie, Philipps-University Marburg , Hans-Meerwein-Strasse 4, D-35043 Marburg, Germany.
authors.forename: Paul
authors.initials: P
authors.lastname: Nikodemiak
authors.affiliation: Fachbereich Chemie, Philipps-University Marburg , Hans-Meerwein-Strasse 4, D-35043 Marburg, Germany.
authors.forename: Ulrich
authors.initials: U
authors.lastname: Koert