title: Effects of Adoptive Transfer of Tolerogenic Dendritic Cells on Allograft Survival in Organ Transplantation Models: An Overview of Systematic Reviews.
abstract: Objective. To dissect the efficacy of Tol-DC therapy with or without IS in multiple animal models of transplantation. Methods and Results. PubMed, Medline, Embase, and the Cochrane Library were searched for reviews published up to April 2015. Six systematic reviews and a total of 61 articles were finally included. Data were grouped by organ transplantation models and applied to meta-analysis. Our meta-analysis shows that Tol-DC therapy successfully prolonged allograft survival to varying extents in all except the islet transplantation models and with IS drugs further prolonged the survival of heart, skin, and islet allografts in mice, but not of heart allografts in rats. Compared with IS drugs alone, Tol-DC therapy with IS extended islet allograft survival in rats but failed to influence the survival of skin, small intestine, and heart allografts in rats or of heart and skin allografts in mice. Conclusion. Tol-DC therapy significantly prolonged multiple allograft survival and further prolonged survival with IS. However, standardized protocols for modification of Tol-DC should be established before its application in clinic.
authors.affiliation: Key Laboratory of Transplant Engineering and Immunology of The Ministry of Health, Regenerative Medical Research Centre, West China Hospital, Sichuan University, Chengdu 610041, China.
authors.forename: Yanni
authors.identifier: 0000-0003-3642-4166
authors.initials: Y
authors.lastname: Zhou
authors.affiliation: Key Laboratory of Transplant Engineering and Immunology of The Ministry of Health, Regenerative Medical Research Centre, West China Hospital, Sichuan University, Chengdu 610041, China.
authors.forename: Juan
authors.initials: J
authors.lastname: Shan
authors.affiliation: Key Laboratory of Transplant Engineering and Immunology of The Ministry of Health, Regenerative Medical Research Centre, West China Hospital, Sichuan University, Chengdu 610041, China.
authors.forename: Yingjia
authors.initials: Y
authors.lastname: Guo
authors.affiliation: Key Laboratory of Transplant Engineering and Immunology of The Ministry of Health, Regenerative Medical Research Centre, West China Hospital, Sichuan University, Chengdu 610041, China.
authors.forename: Shengfu
authors.initials: S
authors.lastname: Li
authors.affiliation: Key Laboratory of Transplant Engineering and Immunology of The Ministry of Health, Regenerative Medical Research Centre, West China Hospital, Sichuan University, Chengdu 610041, China.
authors.forename: Dan
authors.initials: D
authors.lastname: Long
authors.affiliation: Key Laboratory of Transplant Engineering and Immunology of The Ministry of Health, Regenerative Medical Research Centre, West China Hospital, Sichuan University, Chengdu 610041, China; Chinese Cochrane Centre, Chinese Evidence-Based Medicine Centre, West China Hospital, Sichuan University, Chengdu 610041, China.
authors.forename: Youping
authors.identifier: 0000-0003-3187-511X
authors.initials: Y
authors.lastname: Li
authors.affiliation: Key Laboratory of Transplant Engineering and Immunology of The Ministry of Health, Regenerative Medical Research Centre, West China Hospital, Sichuan University, Chengdu 610041, China.
authors.forename: Li
authors.identifier: 0000-0002-0469-5327
authors.initials: L
authors.lastname: Feng
mesh_terms: D019264:Adoptive Transfer / Q000379:methods*; D064591:Allografts / Q000276:immunology; D000818:Animals; D003713:Dendritic Cells / Q000276:immunology*; D004195:Disease Models, Animal; D006085:Graft Survival / Q000276:immunology*; D006801:Humans; D007108:Immune Tolerance; D051379:Mice; D016377:Organ Transplantation; D051381:Rats