title: [Roles of Tumor Infiltrating Lymphocytes in Hematologic Malignancies-Review].
abstract: Hematologic malignancies are the most common childhood malignancy and the main cause of death in pediatric cancer patients. Systemic diagnosis and risk-based treatment in these 30 years have achived a great improvement in pediatric cancer therapy, for example, the event-free 5-years survival rate of childhood acute lymphoblastic leukemia was over 80%. Unfortunately, 20%-25% patients relapsed after-therapy, therefore, the novel therapeutic strategies that can improve survival are urgently required. T lymphocytes are the most potent effective anti-tumor cells. Tumor infiltrating lymphocytes comprise many heterotypic lymphocytes, which mainly are T cells for the adoptive cellular immunotherapy. The success of hematopoietic stem cell transplantation in leukemia therapy indicated that the functional recovery of immune cells plays a significant role in the treatment of hematologic malignancies. The cancer immunotherapy become a new strategy for malignancies, while the role of immunotherapy in hematologic malignancies still remained rarely understood. Herein, the recent research progress about the roles of tumor infiltrating lymphocyte and its potential application for hematologic malignancies are systemically reviewed.
authors.affiliation: Department of Pediatrics, The First Affiliated Hospital of Guangzhou Medical University,Guangzhou 510120,Guangdong Province,China.
authors.forename: Ming
authors.initials: M
authors.lastname: Liang
authors.affiliation: Department of Pediatrics, The First Affiliated Hospital of Guangzhou Medical University,Guangzhou 510120,Guangdong Province,China.E-mail: zhanghuirjh@sjtu.edu.cn.
authors.forename: Hui
authors.initials: H
authors.lastname: Zhang
authors.affiliation: Department of Pediatrics, The First Affiliated Hospital of Guangzhou Medical University,Guangzhou 510120,Guangdong Province,China.E-mail:chen_fuxiong@163.com.
authors.forename: Fu-Xiong
authors.initials: FX
authors.lastname: Chen
mesh_terms: D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D016219:Immunotherapy, Adoptive; D016246:Lymphocytes, Tumor-Infiltrating; D013601:T-Lymphocytes