title: Lesion of the rostromedial tegmental nucleus increases voluntary ethanol consumption and accelerates extinction of ethanol-induced conditioned taste aversion.
abstract: Ethanol has rewarding and aversive properties, and the balance of these properties influences voluntary ethanol consumption. Preclinical and clinical evidence show that the aversive properties of ethanol limit intake. The neural circuits underlying ethanol-induced aversion learning are not fully understood. We have previously shown that the lateral habenula (LHb), a region critical for aversive conditioning, plays an important role in ethanol-directed behaviors. However, the neurocircuitry through which LHb exerts its actions is unknown.
  
  
  
  In the present study, we investigate a role for the rostromedial tegmental nucleus (RMTg), a major LHb projection target, in regulating ethanol-directed behaviors.
  
  
  
  Rats received either sham or RMTg lesions and were studied during voluntary ethanol consumption; operant ethanol self-administration, extinction, and yohimbine-induced reinstatement of ethanol-seeking; and ethanol-induced conditioned taste aversion (CTA).
  
  
  
  RMTg lesions increased voluntary ethanol consumption and accelerated extinction of ethanol-induced CTA.
  
  
  
  The RMTg plays an important role in regulating voluntary ethanol consumption, possibly by mediating ethanol-induced aversive conditioning.
authors.affiliation: Department of Pharmacology and Toxicology, University of Utah, 30 South 2000 East, Salt Lake City, UT, 84112-5820, USA. Chandni.sheth@utah.edu.
authors.forename: Chandni
authors.initials: C
authors.lastname: Sheth
authors.affiliation: Department of Pharmacology and Toxicology, University of Utah, 30 South 2000 East, Salt Lake City, UT, 84112-5820, USA.
authors.forename: Teri M
authors.initials: TM
authors.lastname: Furlong
authors.affiliation: Department of Pharmacology and Toxicology, University of Utah, 30 South 2000 East, Salt Lake City, UT, 84112-5820, USA.
authors.forename: Kristen A
authors.initials: KA
authors.lastname: Keefe
authors.affiliation: Department of Pharmacology and Toxicology, University of Utah, 30 South 2000 East, Salt Lake City, UT, 84112-5820, USA.
authors.forename: Sharif A
authors.initials: SA
authors.lastname: Taha
mesh_terms: D058669:Adrenergic alpha-2 Receptor Antagonists / Q000494:pharmacology; D000818:Animals; D002492:Central Nervous System Depressants / Q000494:pharmacology*; D003214:Conditioning, Classical / Q000187:drug effects; D003216:Conditioning, Operant; D000431:Ethanol / Q000494:pharmacology*; D019262:Habenula; D008297:Male; D011803:Quinine; D051381:Rats; D020318:Rats, Long-Evans; D012439:Saccharin; D012646:Self Administration; D013549:Sweetening Agents; D013649:Taste / Q000187:drug effects*; D013681:Tegmentum Mesencephali; D015016:Yohimbine / Q000494:pharmacology
chemical_list: D058669:Adrenergic alpha-2 Receptor Antagonists; D002492:Central Nervous System Depressants; D013549:Sweetening Agents; D015016:Yohimbine; D000431:Ethanol; D011803:Quinine; D012439:Saccharin
keywords: Aversion; Ethanol; Lateral habenula (LHb); Reward; Rostromedial tegmental nucleus (RMTg)