title: Impact of Serum Antibodies to HPV Serotypes 6, 11, 16, and 18 to Risks of Subsequent Genital HPV Infections in Men: The HIM Study.
abstract: Naturally induced serum antibodies against human papillomavirus (HPV) may affect risks of subsequent incident genital infections by HPV 6, 11, 16, or 18 in men. In this study, we examined the hypothesis by following 4,123 healthy men every 6 months (median follow-up time, 4.1 years). HPV antibodies were measured at baseline using a virus-like particle-based ELISA assay. Genital HPV genotypes were detected using Roche Linear Array. Incidence proportions and 6-month persistence proportions were calculated at 6-month intervals. Kaplan-Meier curves and Cox models were used to assess genotype-specific cumulative incidence and HRs, respectively. HPV 6, 11, 16, and 18 seroprevalence was 8.1%, 13.9%, 12.7%, and 10.8%, respectively. Significantly higher rates of incident infections were observed for HPV 16 among baseline-seropositive men [adjusted HR, 1.37; 95% confidence interval (CI), 1.01-1.86], with similar but nonsignificant HRs for 6-month persistent infections. Risk of persistent HPV 18 infection was significantly lower among seropositive men in the unadjusted model (HR, 0.22; 95% CI, 0.06-0.91), but not in the adjusted model (HR, 0.19; 95% CI, 0.03-1.37). Incident and 6-month persistent infections for HPV 6 and 11 did not differ by baseline serostatus. Baseline serostatus among men was not associated with a reduction in subsequent incident genital HPV 6, 11, and 16 infections. However, protection against persistent HPV18 infections was observed in unadjusted models. Our research suggests a need of further studies to examine the potentially protective effects of naturally induced HPV18 antibodies in men. Cancer Res; 76(20); 6066-75. ©2016 AACR.
authors.affiliation: Center for Infection Research in Cancer, H. Lee Moffitt Cancer Center & Research Institute, Tampa, Florida. Department of Epidemiology and Biostatistics, University of South Florida, Tampa, Florida.
authors.forename: Shitaldas J
authors.initials: SJ
authors.lastname: Pamnani
authors.affiliation: Center for Infection Research in Cancer, H. Lee Moffitt Cancer Center & Research Institute, Tampa, Florida.
authors.forename: Staci L
authors.initials: SL
authors.lastname: Sudenga
authors.affiliation: Department of Pediatrics and Neurovirology, Johns Hopkins School of Medicine, Baltimore, Maryland.
authors.forename: Raphael
authors.initials: R
authors.lastname: Viscidi
authors.affiliation: Department of Epidemiology and Biostatistics, University of South Florida, Tampa, Florida. Department of Cancer Epidemiology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, Florida.
authors.forename: Dana E
authors.initials: DE
authors.lastname: Rollison
authors.affiliation: Department of Biostatistics and Bioinformatics, H. Lee Moffitt Cancer Center & Research Institute, Tampa, Florida.
authors.forename: B Nelson
authors.initials: BN
authors.lastname: Torres
authors.affiliation: Vanderbilt Institute for Global Health, Nashville, Tennessee.
authors.forename: Donna J
authors.initials: DJ
authors.lastname: Ingles
authors.affiliation: Center for Infection Research in Cancer, H. Lee Moffitt Cancer Center & Research Institute, Tampa, Florida.
authors.forename: Martha
authors.initials: M
authors.lastname: Abrahamsen
authors.affiliation: School of Medicine, University of São Paulo, São Paulo, Brazil.
authors.forename: Luisa L
authors.initials: LL
authors.lastname: Villa
authors.affiliation: Instituto Nacional de Salud Pública, Cuernavaca, Mexico.
authors.forename: Eduardo
authors.initials: E
authors.lastname: Lazcano-Ponce
authors.affiliation: Instituto Nacional de Salud Pública, Cuernavaca, Mexico.
authors.forename: Jorge
authors.initials: J
authors.lastname: Salmeron
authors.affiliation: Instituto Nacional de Salud Pública, Cuernavaca, Mexico.
authors.forename: Manuel
authors.initials: M
authors.lastname: Quiterio
authors.affiliation: Department of Epidemiology and Biostatistics, University of South Florida, Tampa, Florida.
authors.forename: Yangxin
authors.initials: Y
authors.lastname: Huang
authors.affiliation: Department of Epidemiology and Biostatistics, University of South Florida, Tampa, Florida.
authors.forename: Amy
authors.initials: A
authors.lastname: Borenstein
authors.affiliation: Center for Infection Research in Cancer, H. Lee Moffitt Cancer Center & Research Institute, Tampa, Florida. anna.giuliano@moffitt.org.
authors.forename: Anna R
authors.initials: AR
authors.lastname: Giuliano
mesh_terms: D000914:Antibodies, Viral / Q000097:blood*; D004279:DNA, Viral / Q000097:blood; D005500:Follow-Up Studies; D005832:Genital Diseases, Male / Q000517:prevention & control*; D052140:Human papillomavirus 11 / Q000276:immunology; D052162:Human papillomavirus 16 / Q000276:immunology; D052161:Human papillomavirus 18 / Q000276:immunology; D052163:Human papillomavirus 6 / Q000276:immunology; D006801:Humans; D015994:Incidence; D008297:Male; D027383:Papillomaviridae / Q000276:immunology*; D030361:Papillomavirus Infections / Q000453:epidemiology* / Q000517:prevention & control; D016016:Proportional Hazards Models; D012306:Risk; D016036:Seroepidemiologic Studies
chemical_list: D000914:Antibodies, Viral; D004279:DNA, Viral