title: From Mild Cognitive Impairment to Alzheimer's Disease: A New Perspective in the "Land" of Human Brain Reactivity and Connectivity.
abstract: In a recent study, analyzing the modulation of γ-band oscillations, Naro and colleagues demonstrated that transcranial alternating current stimulation could drive the gamma rhythms in the human EEG in cognitive healthy elderly subjects but not in mild cognitive impairment (MCI) prodromal to Alzheimer's disease (AD) and in early AD patients. Therefore, this method is proposed to intercept early in the disease course those MCI subjects who are in a pre-symptomatic stage of an already established AD. This prediction index may help the clinician to adopt a better prevention/follow-up strategy. In this direction, the novel advances in EEG analysis for the evaluation of brain reactivity and connectivity-namely via innovative mathematical approach, i.e., graph theory-represent a promising tool for a non-invasive and easy-to-perform neurophysiological marker that could be used for the pre-symptomatic diagnosis of AD and to predict MCI progression to dementia.
authors.affiliation: Department of Geriatrics, Institute of Neurology, Neuroscience and Orthopedics, Catholic University, Policlinic A. Gemelli Foundation, Rome, Italy.|Brain Connectivity Laboratory, IRCCS San Raffaele Pisana, Rome, Italy.
authors.forename: Paolo Maria
authors.initials: PM
authors.lastname: Rossini
authors.affiliation: Department of Geriatrics, Institute of Neurology, Neuroscience and Orthopedics, Catholic University, Policlinic A. Gemelli Foundation, Rome, Italy.
authors.forename: Riccardo
authors.initials: R
authors.lastname: Di Iorio
authors.affiliation: Department of Geriatrics, Institute of Neurology, Neuroscience and Orthopedics, Catholic University, Policlinic A. Gemelli Foundation, Rome, Italy.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Granata
authors.affiliation: Department of Geriatrics, Institute of Neurology, Neuroscience and Orthopedics, Catholic University, Policlinic A. Gemelli Foundation, Rome, Italy.|Brain Connectivity Laboratory, IRCCS San Raffaele Pisana, Rome, Italy.
authors.forename: Francesca
authors.initials: F
authors.lastname: Miraglia
authors.affiliation: Brain Connectivity Laboratory, IRCCS San Raffaele Pisana, Rome, Italy.
authors.forename: Fabrizio
authors.initials: F
authors.lastname: Vecchio
mesh_terms: D000544:Alzheimer Disease / Q000150:complications*; D001921:Brain / Q000502:physiology*; D060825:Cognitive Dysfunction / Q000209:etiology* / Q000628:therapy*; D018450:Disease Progression; D004569:Electroencephalography; D065818:Gamma Rhythm; D006801:Humans; D009434:Neural Pathways / Q000502:physiology; D065908:Transcranial Direct Current Stimulation / Q000379:methods*
keywords: Alzheimer’s disease; effective connectivity; electroencephalography; functional connectivity; graph theory; mild cognitive impairment; non-invasive brain stimulation