title: Integrating genomic information with protein sequence and 3D atomic level structure at the RCSB protein data bank.
abstract: The Protein Data Bank (PDB) now contains more than 120,000 three-dimensional (3D) structures of biological macromolecules. To allow an interpretation of how PDB data relates to other publicly available annotations, we developed a novel data integration platform that maps 3D structural information across various datasets. This integration bridges from the human genome across protein sequence to 3D structure space. We developed novel software solutions for data management and visualization, while incorporating new libraries for web-based visualization using SVG graphics.
  
  
  
  The new views are available from http://www.rcsb.org and software is available from https://github.com/rcsb/.
  
  
  
  andreas.prlic@rcsb.orgSupplementary information: Supplementary data are available at Bioinformatics online.
authors.affiliation: RCSB Protein Data Bank, University of California San Diego, San Diego Supercomputer Center, La Jolla, CA 92093, USA.
authors.forename: Andreas
authors.initials: A
authors.lastname: Prlic
authors.affiliation: RCSB Protein Data Bank, University of California San Diego, San Diego Supercomputer Center, La Jolla, CA 92093, USA.
authors.forename: Tara
authors.initials: T
authors.lastname: Kalro
authors.affiliation: Bioinformatics and Medical Informatics, San Diego State University, San Diego, CA 92182, USA.
authors.forename: Roshni
authors.initials: R
authors.lastname: Bhattacharya
authors.affiliation: RCSB Protein Data Bank, University of California San Diego, San Diego Supercomputer Center, La Jolla, CA 92093, USA.
authors.forename: Cole
authors.initials: C
authors.lastname: Christie
authors.affiliation: RCSB Protein Data Bank, University of California San Diego, San Diego Supercomputer Center, La Jolla, CA 92093, USA.|RCSB Protein Data Bank, Department of Chemistry and Chemical Biology, Center for Integrative Proteomics Research, Institute for Quantitative Biomedicine, and Rutgers Cancer Institute of New Jersey, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA.
authors.forename: Stephen K
authors.initials: SK
authors.lastname: Burley
authors.affiliation: RCSB Protein Data Bank, University of California San Diego, San Diego Supercomputer Center, La Jolla, CA 92093, USA.
authors.forename: Peter W
authors.initials: PW
authors.lastname: Rose
mesh_terms: D000595:Amino Acid Sequence; D019295:Computational Biology / Q000379:methods*; D003196:Computer Graphics; D030562:Databases, Protein; D023281:Genomics; D006801:Humans; D011487:Protein Conformation; D012984:Software; D014584:User-Computer Interface