title: Effect of Strength Training on Oxidative Stress and the Correlation of the Same with Forearm Vasodilatation and Blood Pressure of Hypertensive Elderly Women: A Randomized Clinical Trial.
abstract: The aim of the study was to evaluate the effect of strength training on oxidative stress and the correlation of the same with forearm vasodilatation and mean blood pressure of hypertensive elderly women, at rest (basal) and during a static handgrip exercise. Insufficiently active hypertensive elderly women (N = 25; mean age = 66.1 years) were randomized into a 10 week strength training group (n = 13) or control (n = 12) group. Plasma malondialdehyde (MDA), total antioxidant capacity (TAC), plasma nitrite (NO2-), forearm blood flow (FBF), mean blood pressure (MBP) and vascular conductance ([FBF / MBP] x 100) were evaluated before and after the completion of the interventions. The strength training group increased the TAC (pre: Median = 39.0; Interquartile range = 34.0-41.5% vs post: Median = 44.0; Interquartile range = 38.0-51.5%; p = 0.006) and reduced the MDA (pre: 4.94 ± 1.10 μM vs post: 3.90 ± 1.35 μM; p = 0.025; CI-95%: -1.92 --0.16 μM). The strength training group increased basal vascular conductance (VC) (pre: 3.56 ±0.88 units vs post: 5.21 ±1.28 units; p = 0.001; CI-95%: 0.93-2.38 units) and decreased basal MBP (pre: 93.1 ±6.3 mmHg vs post: 88.9 ±5.4 mmHg; p = 0.035; CI-95%: -8.0 --0.4 mmHg). Such changes were also observed during static handgrip exercise. A moderate correlation was observed between changes in basal VC and MBP with changes in NO2- (ΔVC → r = -0.56, p = 0.047; ΔMBP → r = -0.41, p = 0.168) and MDA (ΔVC → r = 0.64, p = 0.019; ΔMBP → r = 0.31, p = 0.305). The strength training program reduced the oxidative stress of the hypertensive elderly women and this reduction was moderately correlated with their cardiovascular benefits.
  
  
  BACKGROUND
  ensaiosclinicos.gov.br RBR-48c29w.
authors.affiliation: Graduate Associate Program in Physical Education-Universidade Federal da Paraíba, João Pessoa, Brazil.|Research Laboratory for Physical Training Applied to Performance and Health-Universidade Federal da Paraíba, João Pessoa, Brazil.
authors.forename: Filipe Fernandes Oliveira
authors.initials: FF
authors.lastname: Dantas
authors.affiliation: Graduate Associate Program in Physical Education-Universidade Federal da Paraíba, João Pessoa, Brazil.|Research Laboratory for Physical Training Applied to Performance and Health-Universidade Federal da Paraíba, João Pessoa, Brazil.
authors.forename: Maria do Socorro
authors.initials: Mdo S
authors.lastname: Brasileiro-Santos
authors.affiliation: Graduate Associate Program in Physical Education-Universidade Federal da Paraíba, João Pessoa, Brazil.|Research Laboratory for Physical Training Applied to Performance and Health-Universidade Federal da Paraíba, João Pessoa, Brazil.
authors.forename: Rafael Marinho Falcão
authors.initials: RM
authors.lastname: Batista
authors.affiliation: Graduate Associate Program in Physical Education-Universidade Federal da Paraíba, João Pessoa, Brazil.|Research Laboratory for Physical Training Applied to Performance and Health-Universidade Federal da Paraíba, João Pessoa, Brazil.
authors.forename: Leone Severino
authors.initials: LS
authors.lastname: do Nascimento
authors.affiliation: Human Immunology Research and Education Group, Health Technical School-Universidade Federal da Paraíba, João Pessoa, Brazil.
authors.forename: Lúcio Roberto Cançado
authors.initials: LR
authors.lastname: Castellano
authors.affiliation: Hospital Israelita Albert Einstein, São Paulo, Brazil.
authors.forename: Raphael Mendes
authors.initials: RM
authors.lastname: Ritti-Dias
authors.affiliation: Postgraduate Program in Public Health-Universidade Federal do Rio Grande do Norte, Natal, Brazil.
authors.forename: Kenio Costa
authors.initials: KC
authors.lastname: Lima
authors.affiliation: Graduate Associate Program in Physical Education-Universidade Federal da Paraíba, João Pessoa, Brazil.|Research Laboratory for Physical Training Applied to Performance and Health-Universidade Federal da Paraíba, João Pessoa, Brazil.
authors.forename: Amilton da Cruz
authors.initials: Ada C
authors.lastname: Santos
mesh_terms: D000368:Aged; D015415:Biomarkers / Q000097:blood; D001794:Blood Pressure; D005260:Female; D005542:Forearm / Q000098:blood supply*; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000378:metabolism / Q000503:physiopathology* / Q000628:therapy*; D018384:Oxidative Stress; D055070:Resistance Training; D012146:Rest / Q000502:physiology; D014664:Vasodilation
chemical_list: D015415:Biomarkers