title: Materials technology in drug eluting balloons: Current and future perspectives.
abstract: The coating material technology is important for the delivery of anti-proliferative drugs from the surface of drug-eluting balloons (DEBs), which are emerging as alternatives to drug-eluting stents (DES) in the field of interventional cardiology. Currently, several shortcomings limit their competition with DES, including low drug transfer efficiency to the arterial tissues and undesirable particulate generation from the coating matrix. In this review, we provide a survey of the materials used in existing DEBs, and discussed the mechanisms of actions of both the drugs and coating materials. The type of drug and the influence of the coating material characteristics on the drug uptake, distribution and retention in arterial tissues are described. We also summarize the novel coating excipients under development and provide our perspective on the possible use of nano-scale carriers to address the shortcomings of current coating technology. The scope of this review includes only materials that have been approved for biomedical applications or are generally recognized as safe (GRAS) for drug delivery.
authors.affiliation: School of Materials Science and Engineering, Nanyang Technological University, Nanyang Avenue, 639798, Singapore.
authors.forename: Gordon Minru
authors.initials: GM
authors.lastname: Xiong
authors.affiliation: National Heart Centre Singapore, 5 Hospital Drive, 169609, Singapore.
authors.forename: Huiying
authors.initials: H
authors.lastname: Ang
authors.affiliation: National Heart Centre Singapore, 5 Hospital Drive, 169609, Singapore.
authors.forename: Jinjie
authors.initials: J
authors.lastname: Lin
authors.affiliation: School of Materials Science and Engineering, Nanyang Technological University, Nanyang Avenue, 639798, Singapore.
authors.forename: Yuan Siang
authors.initials: YS
authors.lastname: Lui
authors.affiliation: School of Materials Science and Engineering, Nanyang Technological University, Nanyang Avenue, 639798, Singapore.
authors.forename: Jie Liang
authors.initials: JL
authors.lastname: Phua
authors.affiliation: School of Materials Science and Engineering, Nanyang Technological University, Nanyang Avenue, 639798, Singapore.
authors.forename: Jing Ni
authors.initials: JN
authors.lastname: Chan
authors.affiliation: School of Materials Science and Engineering, Nanyang Technological University, Nanyang Avenue, 639798, Singapore.
authors.forename: Subbu
authors.initials: S
authors.lastname: Venkatraman
authors.affiliation: National Heart Centre Singapore, 5 Hospital Drive, 169609, Singapore.
authors.forename: Nicolas
authors.initials: N
authors.lastname: Foin
authors.affiliation: School of Materials Science and Engineering, Nanyang Technological University, Nanyang Avenue, 639798, Singapore. Electronic address: yingyinghuang@ntu.edu.sg.
authors.forename: Yingying
authors.initials: Y
authors.lastname: Huang
mesh_terms: D000818:Animals; D002986:Clinical Trials as Topic / Q000379:methods; D016503:Drug Delivery Systems / Q000379:methods* / Q000639:trends*; D054855:Drug-Eluting Stents / Q000639:trends*; D006801:Humans; D008422:Materials Testing / Q000379:methods*; D049329:Nanostructures / Q000008:administration & dosage / Q000737:chemistry; D017239:Paclitaxel / Q000008:administration & dosage; D058729:Peripheral Arterial Disease / Q000188:drug therapy / Q000378:metabolism; D011474:Prosthesis Design / Q000379:methods / Q000639:trends
chemical_list: D017239:Paclitaxel
keywords: Coating excipient; Drug-eluting balloon; Nanoliposome; Particulate generation; Polymeric nanocarrier