title: A matter of time - How transient transcription factor interactions create dynamic gene regulatory networks.
abstract: Dynamic reprogramming of transcriptional networks enables cells to adapt to a changing environment. Thus, it is crucial not only to understand what gene targets are regulated by a transcription factor (TF) but also when. This review explores the way TFs function with respect to time, paying particular attention to discoveries made in plants - where coordinated, genome-wide responses to environmental change is crucial to the survival of these sessile organisms. We investigate the molecular mechanisms that mediate transient TF-DNA binding, and assess how these rapid and dynamic interactions translate to long-term temporal regulation of genomes. We also discuss how current molecular techniques can catch, and sometimes miss, transient TF-target interactions that underlie dynamic cellular responses. This article is part of a Special Issue entitled: Plant Gene Regulatory Mechanisms and Networks, edited by Dr. Erich Grotewold and Dr. Nathan Springer.
authors.affiliation: Center for Genomics and Systems Biology, Department of Biology, New York University, New York 10003, USA. Electronic address: jas1310@nyu.edu.
authors.forename: Joseph
authors.initials: J
authors.lastname: Swift
authors.affiliation: Center for Genomics and Systems Biology, Department of Biology, New York University, New York 10003, USA.
authors.forename: Gloria M
authors.initials: GM
authors.lastname: Coruzzi
mesh_terms: D004268:DNA-Binding Proteins / Q000235:genetics / Q000378:metabolism; D018506:Gene Expression Regulation, Plant / Q000235:genetics*; D053263:Gene Regulatory Networks / Q000235:genetics*; D018745:Genome, Plant / Q000235:genetics; D010944:Plants / Q000235:genetics* / Q000378:metabolism*; D011485:Protein Binding / Q000235:genetics; D013997:Time Factors; D014157:Transcription Factors / Q000235:genetics* / Q000378:metabolism*; D014158:Transcription, Genetic / Q000235:genetics
chemical_list: D004268:DNA-Binding Proteins; D014157:Transcription Factors
keywords: Epigenetics; Plant genomics; Transcription dynamics; Transcription factor; Transient DNA binding