title: Barrett's esophagus after Roux-en-Y gastric bypass: does regression occur?
abstract: Barrett's esophagus (BE) is recognized as a premalignant lesion for esophageal adenocarcinoma. BE appears as a consequence of gastroesophageal reflux disease (GERD), which is increased among obese population. Laparoscopic Roux-en-Y gastric bypass (LRYGB) is the best treatment option for obesity combined with GERD. However, data on evolution of BE after LRYGB are scarce.
  
  
  
  Patients were studied with esophagogastroduodenoscopy (EGD) and gastric biopsy preoperatively. If BE was suspected, esophageal biopsy was performed. If BE was confirmed, LRYGB was indicated with yearly surveillance EGD with biopsies. LRYGB patients who had BE with at least 1-year follow-up were included.
  
  
  
  Between 10/07 and 1/16, 2144 patients underwent laparoscopic bariatric surgery at our institution. There were 1681 (78 %) LRYGB, 399 (19 %) laparoscopic sleeve gastrectomies, and 64 (3 %) revisions. Nineteen patients (0.9 %) had BE preoperatively, and they all underwent LRYGB; 11 of them (58 %) were eligible for this study. There were 6 women and 5 men, mean age 49 ± 11 years, initial BMI 44 ± 6 kg/m2. Mean follow-up was 41 ± 31 months; there were 9 short-segment BE (SSBE) and 2 long-segment BE (LSBE). On pre- and post-op EGD, BE length was 2.1 ± 1.6 and 1.2 ± 1.2 cm, respectively (p = NS). Post-op EGD was compatible with BE in all cases, although esophageal biopsy showed remission in 4 (36 %) cases: three short-segment BE (SSBE) and one long-segment BE (LSBE). One patient was indefinite for dysplasia and remained the same after the operation.
  
  
  
  Our preliminary data showed that LRYGB is a suitable treatment option for obese patients with BE, demonstrated by 36 % regression rate of this premalignant disease. Although BE persisted in the remaining patients, no progression to dysplasia was observed. A larger number of patients and longer follow-up are needed for more definitive conclusions.
authors.affiliation: Programa de Unidades Bariátricas, Buenos Aires, Argentina. vgorodner_72@yahoo.com.ar.
authors.forename: Verónica
authors.identifier: 0000-0002-0023-2114
authors.initials: V
authors.lastname: Gorodner
authors.affiliation: Programa de Unidades Bariátricas, Buenos Aires, Argentina.
authors.forename: Rudolf
authors.initials: R
authors.lastname: Buxhoeveden
authors.affiliation: Programa de Unidades Bariátricas, Buenos Aires, Argentina.
authors.forename: Gastón
authors.initials: G
authors.lastname: Clemente
authors.affiliation: GEDYT Gastroenterología Diagnóstica y Terapéutica, Buenos Aires, Argentina.
authors.forename: Christian
authors.initials: C
authors.lastname: Sánchez
authors.affiliation: GEDYT Gastroenterología Diagnóstica y Terapéutica, Buenos Aires, Argentina.
authors.forename: Luis
authors.initials: L
authors.lastname: Caro
authors.affiliation: Programa de Unidades Bariátricas, Buenos Aires, Argentina.
authors.forename: Alejandro
authors.initials: A
authors.lastname: Grigaites
mesh_terms: D000328:Adult; D001471:Barrett Esophagus / Q000000981:diagnostic imaging / Q000209:etiology / Q000473:pathology / Q000601:surgery*; D001706:Biopsy; D016145:Endoscopy, Digestive System; D004947:Esophagus / Q000000981:diagnostic imaging / Q000473:pathology; D005260:Female; D005500:Follow-Up Studies; D015390:Gastric Bypass / Q000379:methods; D006801:Humans; D010535:Laparoscopy; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000150:complications / Q000601:surgery*; D012189:Retrospective Studies; D016896:Treatment Outcome
keywords: Barrett’s esophagus; Gastroesophageal reflux disease; Obesity; Roux-en-Y gastric bypass