title: Degradability, cytocompatibility, and osteogenesis of porous scaffolds of nanobredigite and PCL-PEG-PCL composite.
abstract: Biocomposite scaffolds were fabricated by incorporation of nanobredigite (n-BD) into the polymer of poly(ε-caprolactone)-poly(ethyleneglycol)-poly(ε-caprolactone) (PCL-PEG-PCL). The results revealed that the addition of n-BD into PCL-PEG-PCL significantly improved water absorption, compressive strength, and degradability of the scaffolds of n-BD/PCL-PEG-PCL composite (n-BPC) compared with PCL-PEG-PCL scaffolds alone. In addition, the proliferation and alkaline phosphatase activity of MG63 cells cultured on n-BPC scaffolds were obviously higher than that cultured on PCL-PEG-PCL scaffolds. Moreover, the results of the histological evaluation from the animal model revealed that the n-BPC scaffolds significantly improved new bone formation compared with the PCL-PEG-PCL scaffolds, indicating good osteogenesis. The n-BPC scaffolds with good biocompatibility could stimulate cell proliferation, differentiation, and bone tissue regeneration and would be an excellent candidate for bone defect repair.
authors.affiliation: The First Affiliated Hospital of Anhui Medical University, Department of Oral and Maxillofacial Surgery, Hefei.
authors.forename: Jun
authors.initials: J
authors.lastname: Hou
authors.affiliation: Key Laboratory for Ultrafine Materials of Ministry of Education and The State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai.
authors.forename: Donghui
authors.initials: D
authors.lastname: Fan
authors.affiliation: Key Laboratory for Ultrafine Materials of Ministry of Education and The State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai.
authors.forename: Lingming
authors.initials: L
authors.lastname: Zhao
authors.affiliation: Department of Orthopaedics Trauma, Changhai Hospital, Second Military Medical University, Shanghai, People's Republic of China.
authors.forename: Baoqin
authors.initials: B
authors.lastname: Yu
authors.affiliation: Department of Orthopaedics Trauma, Changhai Hospital, Second Military Medical University, Shanghai, People's Republic of China.
authors.forename: Jiacan
authors.initials: J
authors.lastname: Su
authors.affiliation: Key Laboratory for Ultrafine Materials of Ministry of Education and The State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai.
authors.forename: Jie
authors.initials: J
authors.lastname: Wei
authors.affiliation: Department of Biomedical Engineering, Inje University, Gimhae, Republic of Korea.
authors.forename: Jung-Woog
authors.initials: JW
authors.lastname: Shin
mesh_terms: D000469:Alkaline Phosphatase / Q000378:metabolism; D000818:Animals; D001861:Bone Regeneration; D001842:Bone and Bones; D002454:Cell Differentiation; D049109:Cell Proliferation; D019245:Compressive Strength; D008422:Materials Testing; D049329:Nanostructures / Q000737:chemistry; D010012:Osteogenesis / Q000502:physiology*; D011091:Polyesters / Q000737:chemistry*; D011092:Polyethylene Glycols / Q000737:chemistry*; D016062:Porosity; D011817:Rabbits; D023822:Tissue Engineering / Q000379:methods; D054457:Tissue Scaffolds / Q000737:chemistry; D014867:Water
chemical_list: D011091:Polyesters; C515340:poly(epsilon-caprolactone)-b-poly(ethyleneglycol)-b-poly(epsilon-caprolactone); D014867:Water; D011092:Polyethylene Glycols; D000469:Alkaline Phosphatase
keywords: PCL–PEG–PCL; biocomposite scaffolds; degradability; nanobredigite; osteogenesis