title: Reversal agents for NOACs: Connecting the dots.
abstract: OBJECTIVE
  The objective of this review is to provide an overview on the current development of the specific reversal agents for Non-vitamin K Oral Anticoagulants (NOACs).
  
  
  METHODS
  We conducted a systematic literature search strategy to identify potential studies on Medline, Embase, and the Cochrane register.
  
  
  CONCLUSIONS
  These new reversal agents for NOACs, will help address the unmet need for the management of major or life threatening bleeds, and the management of emergency surgical procedures in patients taking NOACs. It will increase confidence in the use of NOACs; thereby extending treatment to a wider range of patients.
authors.affiliation: Director, Centre for Cardiac Sciences, Kokilaben Dhirubhai Ambani Hospital, Rao Saheb Achutrao Patwardhan Marg, Four Bunglows, Andheri (W), Mumbai 400053, India. Electronic address: jjdalal@hotmail.com.
authors.forename: Jamshed
authors.initials: J
authors.lastname: Dalal
authors.affiliation: Hon. Consultant Haematologist, Lilavati Hospital and Research Centre, Mumbai, India.
authors.forename: Abhay
authors.initials: A
authors.lastname: Bhave
authors.affiliation: Senior Manager Medical Affairs, Boehringer Ingelheim India Pvt. Ltd, India.
authors.forename: Gaurav
authors.initials: G
authors.lastname: Chaudhry
authors.affiliation: Manager Medical Services, Boehringer Ingelheim India Pvt. Ltd, India.
authors.forename: Prashant
authors.initials: P
authors.lastname: Rana
mesh_terms: D000284:Administration, Oral; D000925:Anticoagulants / Q000008:administration & dosage*; D001281:Atrial Fibrillation / Q000188:drug therapy*; D006801:Humans; D020300:Intracranial Hemorrhages / Q000517:prevention & control*; D011994:Recombinant Proteins / Q000008:administration & dosage*; D014812:Vitamin K
chemical_list: D000925:Anticoagulants; D011994:Recombinant Proteins; D014812:Vitamin K
keywords: Adexanet alfa; Idarucizumab; NOACs; Reversal agents; SPAF