title: Effects of a multicomponent physical activity behavior change intervention on fatigue, anxiety, and depressive symptomatology in breast cancer survivors: randomized trial.
abstract: OBJECTIVE
  To determine the effects of the 3-month multicomponent Better Exercise Adherence after Treatment for Cancer (BEAT Cancer) physical activity behavior change intervention on fatigue, depressive symptomatology, and anxiety.
  
  
  METHODS
  Postprimary treatment breast cancer survivors (n = 222) were randomized to BEAT Cancer or usual care. Fatigue Symptom Inventory and Hospital Anxiety and Depression Scale were assessed at baseline, postintervention (month 3; M3), and follow-up (month 6; M6).
  
  
  RESULTS
  Adjusted linear mixed-model analyses demonstrated significant effects of BEAT Cancer vs usual care on fatigue intensity (M3 mean between group difference [M] = -0.6; 95% confidence interval [CI] = -1.0 to -0.2; effect size [d] = -0.32; P = .004), fatigue interference (M3 M = -0.8; CI = -1.3 to -0.4; d = -0.40; P < .001), depressive symptomatology (M3 M = -1.3; CI = -2.0 to -0.6; d = -0.38; P < .001), and anxiety (M3 M = -1.3; CI = -2.0 to -0.5; d = -0.33; P < .001). BEAT Cancer effects remained significant at M6 for all outcomes (all P values <.05; d = -0.21 to -.35). Clinically meaningful effects were noted for fatigue intensity, fatigue interference, and depressive symptomatology.
  
  
  CONCLUSIONS
  BEAT Cancer reduces fatigue, depressive symptomatology, and anxiety up to 3 months postintervention in postprimary treatment breast cancer survivors. Further study is needed to determine sustainable methods for disseminating and implementing the beneficial intervention components.
authors.affiliation: Department of Nutrition Sciences, University of Alabama at Birmingham, Birmingham, AL, USA.
authors.forename: Laura Q
authors.initials: LQ
authors.lastname: Rogers
authors.affiliation: Faculty of Physical Education and Recreation, University of Alberta, Edmonton, Alberta, Canada.
authors.forename: Kerry S
authors.initials: KS
authors.lastname: Courneya
authors.affiliation: Department of Kinesiology, Southern Illinois University Carbondale, Carbondale, IL, USA.
authors.forename: Philip M
authors.initials: PM
authors.lastname: Anton
authors.affiliation: Statistics and Research Informatics Core, Center for Clinical Research, Southern Illinois University School of Medicine, Springfield, IL, USA.
authors.forename: Steven
authors.initials: S
authors.lastname: Verhulst
authors.affiliation: Department of Psychiatry, Southern Illinois University School of Medicine, Springfield, IL, USA.
authors.forename: Sandra K
authors.initials: SK
authors.lastname: Vicari
authors.affiliation: Statistics and Research Informatics Core, Center for Clinical Research, Southern Illinois University School of Medicine, Springfield, IL, USA.
authors.forename: Randall S
authors.initials: RS
authors.lastname: Robbs
authors.affiliation: Department of Kinesiology and Community Health, University of Illinois at Urbana-Champaign, Urbana, IL, USA.
authors.forename: Edward
authors.initials: E
authors.lastname: McAuley
mesh_terms: D001007:Anxiety / Q000628:therapy; D001008:Anxiety Disorders; D001943:Breast Neoplasms / Q000503:physiopathology / Q000523:psychology / Q000628:therapy*; D000073116:Cancer Survivors / Q000523:psychology*; D015444:Exercise / Q000502:physiology*; D005081:Exercise Therapy; D005221:Fatigue / Q000628:therapy; D005260:Female; D006801:Humans; D008875:Middle Aged; D009043:Motor Activity; D011788:Quality of Life / Q000523:psychology; D016896:Treatment Outcome
keywords: cancer; exercise; oncology; psychosocial; survivorship