title: Inflammation, immunity, and vaccines for Helicobacter pylori infection.
abstract: The tight control of the innate and adaptive immune responses in the stomach mucosa during chronic Helicobacter pylori infection is of prime importance for the bacteria to persist and for the host to prevent inflammation-driven diseases. This review summarizes recent data on the roles of innate and adaptive immune responses during H. pylori/host interactions. In addition, the latest preclinical developments of H. pylori vaccines are discussed with a special focus on the clinical trial reported by Zeng et al., who provided evidence that oral vaccination significantly reduces the acquisition of natural H. pylori infection in children.
authors.affiliation: Service of Gastroenterology and Hepatology, Department of Medicine, Lausanne University Hospital, Lausanne, Switzerland.
authors.forename: Dominique
authors.initials: D
authors.lastname: Velin
authors.affiliation: ImevaX GmbH, Munich, Germany.
authors.forename: Kathrin
authors.initials: K
authors.lastname: Straubinger
authors.affiliation: ImevaX GmbH, Munich, Germany.|Institute of Medical Microbiology, Immunology and Hygiene, Technische Universität München, Munich, Germany.
authors.forename: Markus
authors.initials: M
authors.lastname: Gerhard
mesh_terms: D001428:Bacterial Vaccines / Q000008:administration & dosage / Q000276:immunology* / Q000302:isolation & purification; D016481:Helicobacter Infections / Q000276:immunology* / Q000473:pathology / Q000517:prevention & control*; D016480:Helicobacter pylori / Q000276:immunology*; D054884:Host-Pathogen Interactions; D006801:Humans; D007249:Inflammation / Q000473:pathology / Q000517:prevention & control*; D016032:Randomized Controlled Trials as Topic
chemical_list: D001428:Bacterial Vaccines
keywords: H. pylori; innate and adaptive immunity; vaccine development