title: Association between Serum Ferritin and Contrast-Induced Nephropathy in Patients with Acute Coronary Syndrome Undergoing Percutaneous Coronary Intervention.
abstract: Background and Aims. CIN is a major and serious complication following PCI in patients with ACS. It is unclear whether a higher serum ferritin level is associated with an increased risk of CIN in high-risk patients. Thus, we conducted this study to assess the predictive value of SF for the risk of CIN after PCI. Methods. We prospectively examined SF levels in 548 patients with ACS before undergoing PCI. Multivariate logistic regression analysis was used to analyze the independent risk factors for CIN. The ROC analysis was performed to evaluate the predictive value of SF for CIN. Results. CIN occurred in 96 patients. Baseline SF was higher in patients who developed CIN compared to those who did not (257.05 ± 93.98 versus 211.67 ± 106.65; P < 0.001). Multivariate logistic regression analysis showed that SF was an independent predictor of CIN (OR, 1.008; 95% CI, 1.003-1.013; P = 0.002). The area under ROC curve for SF was 0.629, and SF > 180.9 μg/L predicted CIN with sensitivity of 80.2% and specificity of 41.4%. Conclusion. Our data show that a higher SF level was significantly associated with an increased risk of CIN after PCI.
authors.affiliation: Department of Cardiology, Zhongda Hospital of Southeast University Medical School, Nanjing 210009, China.
authors.forename: Boqian
authors.initials: B
authors.lastname: Zhu
authors.affiliation: Department of Cardiology, Zhongda Hospital of Southeast University Medical School, Nanjing 210009, China.
authors.forename: Jiantong
authors.initials: J
authors.lastname: Hou
authors.affiliation: Department of Gastroenterology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China.
authors.forename: Yaoyao
authors.initials: Y
authors.lastname: Gong
authors.affiliation: Department of Cardiology, Zhongda Hospital of Southeast University Medical School, Nanjing 210009, China.
authors.forename: Gaoliang
authors.initials: G
authors.lastname: Yan
authors.affiliation: Department of Cardiology, Zhongda Hospital of Southeast University Medical School, Nanjing 210009, China.
authors.forename: Qingjie
authors.initials: Q
authors.lastname: Wang
authors.affiliation: Department of Cardiology, Zhongda Hospital of Southeast University Medical School, Nanjing 210009, China.
authors.forename: Dong
authors.initials: D
authors.lastname: Wang
authors.affiliation: Department of Cardiology, Zhongda Hospital of Southeast University Medical School, Nanjing 210009, China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Qiao
authors.affiliation: Department of Cardiology, Xishan People's Hospital, Wuxi Branch of Zhongda Hospital, Wuxi 214000, China.
authors.forename: Yifei
authors.initials: Y
authors.lastname: Chen
authors.affiliation: Department of Cardiology, Zhongda Hospital of Southeast University Medical School, Nanjing 210009, China.
authors.forename: Chengchun
authors.identifier: 0000-0002-7529-7457
authors.initials: C
authors.lastname: Tang
mesh_terms: D054058:Acute Coronary Syndrome / Q000097:blood / Q000601:surgery; D000368:Aged; D003287:Contrast Media / Q000008:administration & dosage / Q000009:adverse effects*; D005260:Female; D005293:Ferritins / Q000097:blood*; D006801:Humans; D007674:Kidney Diseases / Q000097:blood / Q000139:chemically induced; D008297:Male; D008875:Middle Aged; D062645:Percutaneous Coronary Intervention; D011446:Prospective Studies; D012307:Risk Factors
chemical_list: D003287:Contrast Media; D005293:Ferritins