title: Multi-BRCT scaffolds use distinct strategies to support genome maintenance.
abstract: Genome maintenance requires coordinated actions of diverse DNA metabolism processes. Scaffolding proteins, such as those containing multiple BRCT domains, can influence these processes by collaborating with numerous partners. The best-studied examples of multi-BRCT scaffolds are the budding yeast Dpb11 and its homologues in other organisms, which regulate DNA replication, repair, and damage checkpoints. Recent studies have shed light on another group of multi-BRCT scaffolds, including Rtt107 in budding yeast and related proteins in other organisms. These proteins also influence several DNA metabolism pathways, though they use strategies unlike those employed by the Dpb11 family of proteins. Yet, at the same time, these 2 classes of multi-BRCT proteins can collaborate under specific situations. This review summarizes recent advances in our understanding of how these multi-BRCT proteins function in distinct manners and how they collaborate, with a focus on Dpb11 and Rtt107.
authors: a Molecular Biology Program, Memorial Sloan Kettering Cancer Center , New York , NY , USA.
authors: Bingbing
authors: B
authors: Wan
authors: a Molecular Biology Program, Memorial Sloan Kettering Cancer Center , New York , NY , USA.
authors: Lisa E
authors: LE
authors: Hang
authors: a Molecular Biology Program, Memorial Sloan Kettering Cancer Center , New York , NY , USA.
authors: Xiaolan
authors: X
authors: Zhao
mesh_terms: D059447:Cell Cycle Checkpoints / Q000235:genetics; D016681:Genome, Fungal; D059767:Recombinational DNA Repair / Q000235:genetics; D012441:Saccharomyces cerevisiae / Q000235:genetics* / Q000378:metabolism; D029701:Saccharomyces cerevisiae Proteins / Q000737:chemistry / Q000378:metabolism*; D017386:Sequence Homology, Amino Acid
chemical_list: D029701:Saccharomyces cerevisiae Proteins
keywords: BRCT; DNA damage checkpoint; DNA replication; Dpb11; Recombination; Rtt107; SUMO; ubiquitin