title: Characteristics of histologically confirmed endometriosis in cynomolgus monkeys.
abstract: What are the characteristics of spontaneous endometriosis in cynomolgus monkeys?
  
  
  
  Spontaneous endometriosis in cynomolgus monkeys exhibited similar characteristics to the human disease.
  
  
  
  One previous report described the prevalence and the basic histopathology of spontaneous endometriosis in cynomolgus monkeys.
  
  
  
  Endometriotic lesions that had been histologically confirmed in 8 female cynomolgus monkeys between 5 and 21 years old were subjected to study.
  
  
  
  The monkeys died of, or were sacrificed because of, sickness consequent on endometriosis. Specimens were evaluated histopathologically with haematoxylin and eosin staining, iron staining and immunohistochemistry (CD10, CD31, α-SMA and PGP9.5), and by observing them under a microscope.
  
  
  
  Endometriotic and stromal cells (CD10-positive) with haemorrhage and inflammation were observed. Smooth muscle metaplasia and nerve fibres were also noted in the endometriotic lesions. Endometriotic lesions in lymph nodes were incidentally found.
  
  
  
  Since laparoscopic analysis for monitoring the disease state was not set as a parameter of the current study, time course changes (progression) of the disease were not assessed.
  
  
  
  Further investigation of spontaneous endometriosis in cynomolgus monkeys may contribute to better understanding of the disease pathobiology.
  
  
  
  No external funds were used for this study. A.N.K., S.M., S.H., T.I., O.K., A.K. and M.S. are full-time employees of Chugai Pharmaceutical Co., Ltd. R.K. received lecture fees from Chugai Pharmaceutical Co., Ltd., unrelated to the submitted work. S.N., S. O., L.Y., K.Y. and T.S. have nothing to declare.
  
  
  
  N/A.
authors: Research Division, Chugai Pharmaceutical Co., Ltd., 200 Kajiwara, Kamakura-shi, Kanagawa 247-8530, Japan.
authors: A
authors: A
authors: Nishimoto-Kakiuchi
authors: Department of Obstetrics and Gynecology, Jichi Medical University Saitama Medical Center, 1-847 Amanumacho, Omiya-ku, Saitama-shi, Saitama 330-8503, Japan.
authors: S
authors: S
authors: Netsu
authors: Research Division, Chugai Pharmaceutical Co., Ltd., 200 Kajiwara, Kamakura-shi, Kanagawa 247-8530, Japan.
authors: S
authors: S
authors: Matsuo
authors: Research Division, Chugai Pharmaceutical Co., Ltd., 200 Kajiwara, Kamakura-shi, Kanagawa 247-8530, Japan.
authors: S
authors: S
authors: Hayashi
authors: Research Division, Chugai Pharmaceutical Co., Ltd., 200 Kajiwara, Kamakura-shi, Kanagawa 247-8530, Japan.
authors: T
authors: T
authors: Ito
authors: Tsukuba Primate Research Center, National Institute of Biomedical Innovation, Health and Nutrition, 1-1 Hachimandai, Tsukuba-shi, Ibaraki 305-0843, Japan.
authors: S
authors: S
authors: Okabayashi
authors: Tsukuba Primate Research Center, National Institute of Biomedical Innovation, Health and Nutrition, 1-1 Hachimandai, Tsukuba-shi, Ibaraki 305-0843, Japan.
authors: L
authors: L
authors: Yasmin
authors: Tsukuba Primate Research Center, National Institute of Biomedical Innovation, Health and Nutrition, 1-1 Hachimandai, Tsukuba-shi, Ibaraki 305-0843, Japan.
authors: K
authors: K
authors: Yuzawa
authors: Research Division, Chugai Pharmaceutical Co., Ltd., 200 Kajiwara, Kamakura-shi, Kanagawa 247-8530, Japan.
authors: O
authors: O
authors: Kondoh
authors: Research Division, Chugai Pharmaceutical Co., Ltd., 200 Kajiwara, Kamakura-shi, Kanagawa 247-8530, Japan.
authors: A
authors: A
authors: Kato
authors: Research Division, Chugai Pharmaceutical Co., Ltd., 200 Kajiwara, Kamakura-shi, Kanagawa 247-8530, Japan.
authors: M
authors: M
authors: Suzuki
authors: Department of Obstetrics and Gynecology, Jichi Medical University Saitama Medical Center, 1-847 Amanumacho, Omiya-ku, Saitama-shi, Saitama 330-8503, Japan.
authors: R
authors: R
authors: Konno
authors: Tsukuba Primate Research Center, National Institute of Biomedical Innovation, Health and Nutrition, 1-1 Hachimandai, Tsukuba-shi, Ibaraki 305-0843, Japan t-sankai@nibiohn.go.jp.
authors: T
authors: T
authors: Sankai
mesh_terms: D000818:Animals; D049109:Cell Proliferation; D004715:Endometriosis / Q000473:pathology*; D004717:Endometrium / Q000473:pathology*; D005260:Female; D005355:Fibrosis / Q000473:pathology; D008198:Lymph Nodes / Q000473:pathology; D008252:Macaca fascicularis; D010049:Ovarian Diseases / Q000473:pathology*; D017154:Stromal Cells / Q000473:pathology*
keywords: adenomyosis; cynomolgus monkey; deep infiltrating endometriosis; endometriosis; lymph node; nerve fibre; smooth muscle metaplasia; spontaneous animal model