title: Practical Synthesis of Spermine, Thermospermine and Norspermine.
abstract: Polyamines, such as spermine (1), thermospermine (2) and norspermine (3), are widely distributed in nature, and have multiple biological activities. In addition, many of their conjugates have potential for pharmacological use. Here, we present a solid-phase synthesis using our nitrobenzenesulfonyl (Ns) strategy, which can provide 1, 2 and 3 on a gram scale. This approach should be suitable for facile construction of a diverse library of polyamines.
authors: School of Pharmaceutical Sciences, University of Shizuoka.
authors: Yuka
authors: Y
authors: Kariya
authors: Yuta
authors: Y
authors: Asanuma
authors: Makoto
authors: M
authors: Inai
authors: Tomohiro
authors: T
authors: Asakawa
authors: Kyoko
authors: K
authors: Ohashi-Ito
authors: Hiroo
authors: H
authors: Fukuda
authors: Masahiro
authors: M
authors: Egi
authors: Toshiyuki
authors: T
authors: Kan
mesh_terms: D015394:Molecular Structure; D013096:Spermine / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D013096:Spermine; C017921:norspermine; C021097:thermospermine