title: Biocompatibility of Plastic Clip in Neurocranium - Experimental Study on Dogs.
abstract: OBJECTIVE
  A potential advantage of the use of the plastic clips in neurosurgery is their property of causing fewer artifacts than titanium clips as assessed by computed tomography and magnetic resonance scans. The biocompatibility of plastic clips was demonstrated in the peritoneal cavity, but their behavior in the neurocranium is not known.
  
  
  METHODS
  Twelve aggressive stray dogs designated for euthanasia were taken for this experimental study. The animals were divided into two groups. In all cases, after anesthesia, a craniotomy was performed, and after opening the dura, a proximal part titanium clip was placed on the isolated superficial Sylvian vein (a permanent Yasargil FT 746 T clip at a 90° angle, while a plastic Hem-o-lok clip ML was placed on another part of the vein). The first group of animals was sacrificed on the 7 < sup > th < /sup > postoperative day and the second group on the 60 < sup > th < /sup > postoperative day. Samples of tissue around the clips were taken for a histopathological evaluation.
  
  
  RESULTS
  The plastic clip caused a more intensive tissue reaction than the titanium clip on the 7 < sup > th < /sup > postoperative day, but there was no statistical difference. Even on the 60 < sup > th < /sup > postoperative day there was no significant difference in tissue reaction between the titanium and plastic clips.
  
  
  CONCLUSIONS
  These preliminary results confirm the possibility for the use of plastic clips in neurosurgery. Before their use in human neurosurgery, further studies are needed to investigate the long-term effects of the presence of plastic clips in the neurocranium, as well as studies of the aneurysmal model.
authors: University Clinical Center Tuzla, Department of Surgery, Bosnia and Herzegovina.
authors: Samir
authors: S
authors: Delibegovic
authors: Kemal
authors: K
authors: Dizdarevic
authors: Elmir
authors: E
authors: Cickusic
authors: Muhamed
authors: M
authors: Katica
authors: Muamer
authors: M
authors: Obhodjas
authors: Muhamed
authors: M
authors: Ocus
mesh_terms: D000818:Animals; D003399:Craniotomy / Q000295:instrumentation*; D004285:Dogs; D008422:Materials Testing; D010969:Plastics / Q000009:adverse effects*; D013525:Surgical Instruments / Q000009:adverse effects*; D014025:Titanium / Q000009:adverse effects*
chemical_list: D010969:Plastics; D014025:Titanium