title: Esophagectomy Following Endoscopic Resection of Submucosal Esophageal Cancer: a Highly Curative Procedure Even with Nodal Metastases.
abstract: Despite the increased risk for nodal disease, definitive endoscopic resection is being increasingly offered for lesions invasive into the submucosa based on the success with intramucosal tumors. The aim of this study was to evaluate survival after esophagectomy alone for confirmed submucosal tumors after endoscopic resection.
  
  
  
  Patients from seven centers in the USA who underwent esophagectomy for submucosal tumors removed with endoscopic resection were analyzed. Nodal involvement was correlated with recurrence and survival.
  
  
  
  We identified 23 patients with submucosal esophageal adenocarcinoma. Esophagectomy was performed at a median of 2 months (Interquartile range 1-3) after the endoscopic resection. There was no postoperative mortality. Positive nodal disease was seen in 26 % of patients on final pathology. At a median of 37 months (Interquartile range 25-55), 91 % of patients were alive and free of disease. The disease-specific 5-year survival was 88 %. Disease-specific 5-year survival was 67 % in patients with positive nodal metastases and 100 % in those without (p = 0.159).
  
  
  
  Esophagectomy is curative in the majority of patients with submucosal tumors even in the presence of nodal metastases. These data serve as a benchmark for comparison when considering extending the indications for therapeutic endoscopic resection for submucosal tumors in the future.
authors: Thoracic Surgery Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY, 10065, USA. molenad@mskcc.org.
authors: Daniela
authors: D
authors: Molena
authors: Thoracic Surgery Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY, 10065, USA.
authors: Francisco
authors: F
authors: Schlottmann
authors: Department of Surgery, University of Southern California, Keck School of Medicine, Los Angeles, CA, USA.
authors: Joshua A
authors: JA
authors: Boys
authors: Department of Surgery, Mayo Clinic, Rochester, MN, USA.
authors: Shanda H
authors: SH
authors: Blackmon
authors: Department of Surgery, Mayo Clinic, Rochester, MN, USA.
authors: Karen J
authors: KJ
authors: Dickinson
authors: Department of Surgery, The Oregon Clinic, Portland, OR, USA.
authors: Christy M
authors: CM
authors: Dunst
authors: Department of Surgery, MD Anderson, Houston, TX, USA.
authors: Wayne L
authors: WL
authors: Hofstetter
authors: Department of Surgery, University of Rochester Medical Center, Rochester, NY, USA.
authors: Michal J
authors: MJ
authors: Lada
authors: Department of Surgery, Swedish Cancer Institute, Seattle, WA, USA.
authors: Brian E
authors: BE
authors: Louie
authors: Department of Surgery, Johns Hopkins University, Baltimore, MD, USA.
authors: Benedetto
authors: B
authors: Mungo
authors: Department of Surgery, University of Rochester Medical Center, Rochester, NY, USA.
authors: Thomas J
authors: TJ
authors: Watson
authors: Department of Surgery, University of Southern California, Keck School of Medicine, Los Angeles, CA, USA.
authors: Steven R
authors: SR
authors: DeMeester
mesh_terms: D000230:Adenocarcinoma / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D000368:Aged; D000369:Aged, 80 and over; D000071041:Esophageal Mucosa / Q000601:surgery*; D004938:Esophageal Neoplasms / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D016629:Esophagectomy / Q000379:methods / Q000401:mortality*; D004945:Esophagoscopy; D005260:Female; D006801:Humans; D008198:Lymph Nodes / Q000473:pathology; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D016019:Survival Analysis
keywords: Endoscopic therapy; Esophageal cancer; Esophagectomy; T1b adenocarcinoma