title: Adult height associates with angiographic extent of coronary artery disease.
abstract: Shorter stature is an established risk factor for coronary artery disease (CAD), but less is known about its association with extent of the disease.
  
  
  
  We assessed the relationship between self-reported height and angiographic findings in 7706 men and 3572 women identified from a nationwide coronary angiography registry in Iceland.
  
  
  
  After adjustment for traditional cardiovascular risk factors, a standard deviation decrease in height associated with a greater likelihood of significant CAD (defined as ≥50% luminal diameter stenosis) both in men (adjusted odds ratio [ORadj]: 1.24, 95% confidence interval [CI]: 1.18, 1.31; p = 3.2 × 10-16) and women (ORadj= 1.10, 95% CI: 1.02, 1.18; p = 0.012). In partial proportional odds logistic regression models, a standard deviation decrease in height was associated with higher odds of having greater extent of CAD in men (ORadj= 1.19, 95% CI: 1.15, 1.25; p = 1.5 × 10-16) and women (ORadj= 1.09, 95% CI: 1.02, 1.16; p = 0.014). When limited to patients with significant CAD, the association was statistically significant in men (ORadj= 1.08, 95% CI: 1.03, 1.14; p = 0.0022) but not in women (p = 0.56).
  
  
  
  Our findings show that shorter stature is associated with greater extent of coronary atherosclerosis in a large unselected population of individuals undergoing coronary angiography. This relationship appears to be sex-dependent, with stronger effects in men than in women.
authors: Faculty of Medicine, University of Iceland, Vatnsmyrarvegur 16, 101 Reykjavik, Iceland.
authors: Eythor
authors: E
authors: Bjornsson
authors: Faculty of Medicine, University of Iceland, Vatnsmyrarvegur 16, 101 Reykjavik, Iceland; Division of Cardiology and Cardiovascular Research Center, Department of Internal Medicine, Landspitali University Hospital, Hringbraut, 101 Reykjavik, Iceland.
authors: Gudmundur
authors: G
authors: Thorgeirsson
authors: Division of Cardiology and Cardiovascular Research Center, Department of Internal Medicine, Landspitali University Hospital, Hringbraut, 101 Reykjavik, Iceland. Electronic address: thg@simnet.is.
authors: Thorarinn
authors: T
authors: Gudnason
mesh_terms: D000328:Adult; D000368:Aged; D050197:Atherosclerosis / Q000000981:diagnostic imaging / Q000503:physiopathology; D001827:Body Height; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D005260:Female; D006801:Humans; D007055:Iceland; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D012042:Registries; D012044:Regression Analysis; D012307:Risk Factors; D018401:Sample Size; D012737:Sex Factors; D013548:Sweden
keywords: Atherosclerosis; Coronary angiography; Coronary artery disease; Height