title: Clinical features of migraine aura: Results from a prospective diary-aided study.
abstract: Background A detailed evaluation of migraine aura symptoms is crucial for classification issues and pathophysiological discussion. Few studies have focused on the detailed clinical aspects of migraine aura. Methods We conducted a prospective diary-based study of migraine aura features including presence, quality, laterality, duration of each aura symptom, their temporal succession; presence of headache and its temporal succession with aura. Results Seventy-two patients completed the study recording the characteristics of three consecutive auras ( n = 216 auras). Visual symptoms occurred in 212 (98%), sensory symptoms in 77 (36%) and dysphasic symptoms in 22 (10%). Most auras had more than one visual symptom (median 2, IQR 1-3, range 1-4). The majority of patients (56%) did not report a stereotyped aura on the three attacks with respect to visual features, the combination and/or temporal succession of the three aura symptoms. Fifty-seven percent of patients also reported a different scenario of temporal succession between aura and headache in the three attacks. Five per cent of aura symptoms were longer than four hours. Conclusion These findings show a high inter- and intravariability of migraine with aura attacks. Furthermore, they provide reliable data to enrich and clarify the spectrum of the aura phenotype.
authors: 1 Headache Science Center, C. Mondino National Neurological Institute, Pavia, Italy.
authors: Michele
authors: M
authors: Viana
authors: 1 Headache Science Center, C. Mondino National Neurological Institute, Pavia, Italy.
authors: Grazia
authors: G
authors: Sances
authors: 2 Department of Neuroscience, Norwegian University of Science and Technology, Trondheim, Norway.|3 Norwegian Advisory Unit on Headaches, St Olavs University Hospital, Trondheim, Norway.
authors: Mattias
authors: M
authors: Linde
authors: 1 Headache Science Center, C. Mondino National Neurological Institute, Pavia, Italy.
authors: Natascia
authors: N
authors: Ghiotto
authors: 1 Headache Science Center, C. Mondino National Neurological Institute, Pavia, Italy.
authors: Elena
authors: E
authors: Guaschino
authors: 1 Headache Science Center, C. Mondino National Neurological Institute, Pavia, Italy.
authors: Marta
authors: M
authors: Allena
authors: 4 Department of Pharmaceutical Sciences, Università del Piemonte Orientale 'A. Avogadro', Italy.
authors: Salvatore
authors: S
authors: Terrazzino
authors: 1 Headache Science Center, C. Mondino National Neurological Institute, Pavia, Italy.
authors: Giuseppe
authors: G
authors: Nappi
authors: 5 Headache Group - NIHR-Wellcome Trust King's Clinical Research Facility, King's College London, UK.
authors: Peter J
authors: PJ
authors: Goadsby
authors: 1 Headache Science Center, C. Mondino National Neurological Institute, Pavia, Italy.|6 Department of Brain and Behavioural Sciences, University of Pavia, Italy.
authors: Cristina
authors: C
authors: Tassorelli
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D008297:Male; D008499:Medical Records; D008875:Middle Aged; D020325:Migraine with Aura / Q000175:diagnosis* / Q000453:epidemiology / Q000503:physiopathology*; D011446:Prospective Studies; D055815:Young Adult
keywords: Migraine with aura; aura symptoms; characteristic; feature; sensory; visual