title: Development of chiral metal amides as highly reactive catalysts for asymmetric [3 + 2] cycloadditions.
abstract: Highly efficient catalytic asymmetric [3 + 2] cycloadditions using a chiral copper amide are reported. Compared with the chiral CuOTf/Et3N system, the CuHMDS system showed higher reactivity, and the desired reactions proceeded in high yields and high selectivities with catalyst loadings as low as 0.01 mol %.
authors: Department of Chemistry, School of Science, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo, Japan.
authors: Yasuhiro
authors: Y
authors: Yamashita
authors: Department of Chemistry, School of Science, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo, Japan.
authors: Susumu
authors: S
authors: Yoshimoto
authors: Department of Chemistry, School of Science, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo, Japan.
authors: Mark J
authors: MJ
authors: Dutton
authors: Department of Chemistry, School of Science, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo, Japan.
authors: Shū
authors: S
authors: Kobayashi
keywords: [3 + 2] cycloaddition; asymmetric reaction; catalytic reaction; low catalyst loading; metal amide