title: MNX1 Is Oncogenically Upregulated in African-American Prostate Cancer.
abstract: Incidence and mortality rates for prostate cancer are higher in African-American (AA) men than in European-American (EA) men, but the biologic basis for this disparity is unclear. We carried out a detailed analysis of gene expression changes in prostate cancer compared with their matched benign tissues in a cohort of AA men and compared them with existing data from EA men. In this manner, we identified MNX1 as a novel oncogene upregulated to a relatively greater degree in prostate cancer from AA men. Androgen and AKT signaling play a central role in the pathogenesis of prostate cancer and we found that both of these signaling pathways increased MNX1 expression. MNX1 in turn upregulated lipid synthesis by stimulating expression of SREBP1 and fatty acid synthetase. Our results define MNX1 as a novel targetable oncogene increased in AA prostate cancer that is associated with aggressive disease. Cancer Res; 76(21); 6290-8. ©2016 AACR.
authors: Department of Biochemistry and Molecular Biology, College of Basic Medical Sciences, Third Military Medical University, Chongqing, China.|Department of Pathology and Immunology and Michael E. DeBakey Veterans Affairs Medical Center, Houston, Texas.
authors: Li
authors: L
authors: Zhang
authors: Department of Pathology and Immunology and Michael E. DeBakey Veterans Affairs Medical Center, Houston, Texas.
authors: Jianghua
authors: J
authors: Wang
authors: Department of Pathology and Immunology and Michael E. DeBakey Veterans Affairs Medical Center, Houston, Texas.
authors: Yongquan
authors: Y
authors: Wang
authors: Division of Biostatistics, Dan L. Duncan Cancer Center, Houston, Texas.
authors: Yiqun
authors: Y
authors: Zhang
authors: Department of Pathology and Immunology and Michael E. DeBakey Veterans Affairs Medical Center, Houston, Texas.
authors: Patricia
authors: P
authors: Castro
authors: Department of Pathology and Immunology and Michael E. DeBakey Veterans Affairs Medical Center, Houston, Texas.
authors: Longjiang
authors: L
authors: Shao
authors: Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas.|Verna and Marrs McLean Department of Biochemistry, Baylor College of Medicine, Houston, Texas.|Alkek Center for Molecular Discovery, Baylor College of Medicine, Houston, Texas.
authors: Arun
authors: A
authors: Sreekumar
authors: Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas.|Verna and Marrs McLean Department of Biochemistry, Baylor College of Medicine, Houston, Texas.|Alkek Center for Molecular Discovery, Baylor College of Medicine, Houston, Texas.
authors: Nagireddy
authors: N
authors: Putluri
authors: Agilent Technologies India Pvt. Ltd, Bangalore, India.
authors: Nilanjan
authors: N
authors: Guha
authors: Agilent Technologies India Pvt. Ltd, Bangalore, India.
authors: Saligrama
authors: S
authors: Deepak
authors: Agilent Technologies India Pvt. Ltd, Bangalore, India.
authors: Arunkumar
authors: A
authors: Padmanaban
authors: Division of Biostatistics, Dan L. Duncan Cancer Center, Houston, Texas.|Department of Medicine, Baylor College of Medicine, Houston, Texas.
authors: Chad J
authors: CJ
authors: Creighton
authors: Department of Pathology and Immunology and Michael E. DeBakey Veterans Affairs Medical Center, Houston, Texas. mittmann@bcm.edu.
authors: Michael
authors: M
authors: Ittmann
mesh_terms: D001741:Black or African American; D000818:Animals; D045744:Cell Line, Tumor; D015972:Gene Expression Regulation, Neoplastic; D018398:Homeodomain Proteins / Q000235:genetics*; D006801:Humans; D008297:Male; D051379:Mice; D009857:Oncogenes; D011471:Prostatic Neoplasms / Q000208:ethnology / Q000235:genetics*; D051057:Proto-Oncogene Proteins c-akt / Q000502:physiology; D011944:Receptors, Androgen / Q000502:physiology; D051780:Sterol Regulatory Element Binding Protein 1 / Q000235:genetics; D014157:Transcription Factors / Q000235:genetics*
chemical_list: C410798:AR protein, human; D018398:Homeodomain Proteins; C490003:MNX1 protein, human; D011944:Receptors, Androgen; C497387:SREBF1 protein, human; D051780:Sterol Regulatory Element Binding Protein 1; D014157:Transcription Factors; D051057:Proto-Oncogene Proteins c-akt