title: Decolonisation of meticillin-resistant Staphylococcus aureus (MRSA) carriage in adopted children with cleft lip and palate.
abstract: This study aimed to determine the percentage success and to investigate influencing factors of meticillin-resistant Staphylococcus aureus (MRSA) decolonisation treatment in children with cleft lip and/or palate (CLP) who are adopted to The Netherlands. This was a historic cohort study in nine Dutch hospitals with a CLP treatment centre of children who were adopted from abroad in 2005-2012 who had CLP and MRSA carriage upon arrival in The Netherlands. A total of 55 adopted children with CLP and MRSA carriage were eligible for the study. Most children were adopted from China and had cheilognathopalatoschisis. Fourteen children were not treated for MRSA carriage, of whom six became MRSA-negative spontaneously. Forty-one children received decolonisation treatment (either topical treatment and disinfectant body wash or these combined with oral antibiotics). Overall, eighteen children [44%; 95% confidence interval (CI) 29-59%] became MRSA-negative after treatment. Treatment success was higher (56%; 95% CI 33-77%) in the group of children treated according to the Dutch guideline for treatment of MRSA carriage (odds ratio=6.1, 95% CI 4.4-26.4; p=0.017). In conclusion, MRSA decolonisation treatment in adopted children with CLP was successful in 44% of cases and the success percentage was higher in the group of children treated in accordance with the national guideline for treatment of MRSA carriage. However, given the percentage of children who turned MRSA-negative without treatment, waiting for spontaneous clearance of MRSA carriage can be advised after careful consideration of the benefits and risks of decolonisation treatment.
authors: Radboud University Medical Center, Department of Medical Microbiology Nijmegen, The Netherlands. Electronic address: Rita.Bos@radboudumc.nl.
authors: Maria
authors: M
authors: Bos
authors: Radboud University Medical Center, Department of Medical Microbiology Nijmegen, The Netherlands.
authors: Joost
authors: J
authors: Hopman
authors: Academic Medical Center-University of Amsterdam, Department of Clinical Epidemiology, Biostatistics and Bioinformatics, Amsterdam, The Netherlands.
authors: Martijn M
authors: MM
authors: Stuiver
authors: Radboud University Medical Center, Department of Medical Microbiology Nijmegen, The Netherlands; Canisius-Wilhelmina Hospital, Nijmegen, The Netherlands.
authors: Andreas
authors: A
authors: Voss
mesh_terms: D002353:Carrier State / Q000188:drug therapy* / Q000382:microbiology; D000073922:Child, Adopted; D002675:Child, Preschool; D002681:China; D002971:Cleft Lip / Q000382:microbiology*; D002972:Cleft Palate / Q000382:microbiology*; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D055624:Methicillin-Resistant Staphylococcus aureus / Q000302:isolation & purification*; D009426:Netherlands; D012189:Retrospective Studies; D013203:Staphylococcal Infections / Q000188:drug therapy*
keywords: Adoption; Children; Cleft lip; Cleft palate; MRSA decolonisation