title: Efficient Catalyst One-Pot Synthesis of 7-(Aryl)-10,10-dimethyl-10,11-dihydrochromeno[4,3-b]chromene-6,8(7H,9H)-dione Derivatives Complemented by Antibacterial Activity.
abstract: The problem of bacteria resistance to many known agents has inspired scientists and researchers to discover novel efficient antibacterial drugs. Three rapid, clean, and highly efficient methods were developed for one-pot synthesis of 7-(aryl)-10,10-dimethyl-10,11-dihydrochromeno[4,3-b]chromene-6,8(7H,9H)-dione derivatives. Three components are condensed in the synthesis, 4-hydroxycoumarin, 5,5-dimethyl-1,3-cyclohexanedione, and aromatic aldehydes, using tetrabutylammonium bromide (TBAB), diammonium hydrogen phosphate (DAHP), or ferric chloride (FeCl3), respectively. Each method has different reaction mechanisms according to the catalyst. The present methods have advantages, including one-pot synthesis, excellent yields, short reaction times, and easy isolation of product. All catalysts utilized in our study could be reused several times without losing their catalytic efficiency. All synthesized compounds were fully characterized and evaluated for their antibacterial activity.
authors: Department of Chemical and Process Engineering, Universiti Kebangsaan Malaysia (UKM), 43000 Bangi, Selangor, Malaysia.
authors: Yasameen K
authors: YK
authors: Al-Majedy
authors: Department of Chemical and Process Engineering, Universiti Kebangsaan Malaysia (UKM), 43000 Bangi, Selangor, Malaysia; Environmental Research Center, University of Technology (UOT), Baghdad 10001, Iraq.
authors: Ahmed A
authors: 0000-0003-1033-4904
authors: AA
authors: Al-Amiery
authors: Department of Chemical and Process Engineering, Universiti Kebangsaan Malaysia (UKM), 43000 Bangi, Selangor, Malaysia.
authors: Abdul Amir H
authors: AA
authors: Kadhum
authors: Department of Chemical and Process Engineering, Universiti Kebangsaan Malaysia (UKM), 43000 Bangi, Selangor, Malaysia; Fuel Cell Institute, Universiti Kebangsaan Malaysia (UKM), 43000 Bangi, Selangor, Malaysia.
authors: Abu Bakar
authors: AB
authors: Mohamad
mesh_terms: D015110:4-Hydroxycoumarins / Q000138:chemical synthesis* / Q000494:pharmacology; D000447:Aldehydes / Q000138:chemical synthesis / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D000975:Antioxidants / Q000138:chemical synthesis / Q000737:chemistry; D002384:Catalysis; D003512:Cyclohexanones / Q000138:chemical synthesis* / Q000494:pharmacology; D006801:Humans; D013211:Staphylococcus aureus / Q000187:drug effects* / Q000472:pathogenicity; D013882:Thiosemicarbazones / Q000138:chemical synthesis* / Q000494:pharmacology
chemical_list: D015110:4-Hydroxycoumarins; D000447:Aldehydes; D000900:Anti-Bacterial Agents; D000975:Antioxidants; D003512:Cyclohexanones; D013882:Thiosemicarbazones; C043593:5,5-dimethyl-1,3-cyclohexanedione bis(thiosemicarbazone); C068805:4-hydroxycoumarin