title: Acylphloroglucinolated Catechin and Phenylethyl Isocoumarin Derivatives from Agrimonia pilosa.
abstract: Eight new compounds (1-8), including five acylphloroglucinolated catechins (1-5) and three phenylethyl isocoumarin glycosides (6-8), were isolated from Agrimonia pilosa along with six other known compounds (9-14). The new compounds were characterized structurally by NMR, MS, and ECD analyses. Compounds 4 and 5 were assigned as acylphloroglucinolated procyanidin derivatives, which are described for the first time from Nature. The absolute configuration of compound 8 was elucidated by computational analysis of its ECD spectrum. The isolated compounds were evaluated for their inhibitory activity against lipopolysaccharide-induced NO production in BV2 microglial cells.
authors: College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University , Gwanak-gu, Seoul 08826, Republic of Korea.
authors: Hyun Woo
authors: HW
authors: Kim
authors: College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University , Gwanak-gu, Seoul 08826, Republic of Korea.
authors: Junha
authors: J
authors: Park
authors: College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University , Gwanak-gu, Seoul 08826, Republic of Korea.
authors: Kyo Bin
authors: KB
authors: Kang
authors: College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University , Gwanak-gu, Seoul 08826, Republic of Korea.
authors: Tae Bum
authors: TB
authors: Kim
authors: College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University , Gwanak-gu, Seoul 08826, Republic of Korea.
authors: Won Keun
authors: WK
authors: Oh
authors: College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University , Gwanak-gu, Seoul 08826, Republic of Korea.
authors: Jinwoong
authors: J
authors: Kim
authors: College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University , Gwanak-gu, Seoul 08826, Republic of Korea.
authors: Sang Hyun
authors: SH
authors: Sung
mesh_terms: D031981:Agrimonia / Q000737:chemistry*; D000818:Animals; D044946:Biflavonoids; D002392:Catechin / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D049934:Isocoumarins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D008070:Lipopolysaccharides / Q000494:pharmacology; D008264:Macrophages / Q000187:drug effects; D051379:Mice; D015394:Molecular Structure; D009569:Nitric Oxide / Q000096:biosynthesis; D019906:Nuclear Magnetic Resonance, Biomolecular; D010696:Phloroglucinol / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification; D044945:Proanthocyanidins; D056910:Republic of Korea
chemical_list: D044946:Biflavonoids; D004365:Drugs, Chinese Herbal; D006027:Glycosides; D049934:Isocoumarins; D008070:Lipopolysaccharides; D044945:Proanthocyanidins; D009569:Nitric Oxide; C017674:procyanidin; D002392:Catechin; D010696:Phloroglucinol