title: Helicobacter pylori, Cancer, and the Gastric Microbiota.
abstract: Gastric adenocarcinoma is one of the leading causes of cancer-related death worldwide and Helicobacter pylori infection is the strongest known risk factor for this disease. Although the stomach was once thought to be a sterile environment, it is now known to house many bacterial species leading to a complex interplay between H. pylori and other residents of the gastric microbiota. In addition to the role of H. pylori virulence factors, host genetic polymorphisms, and diet, it is now becoming clear that components of the gastrointestinal microbiota may also influence H. pylori-induced pathogenesis. In this chapter, we discuss emerging data regarding the gastric microbiota in humans and animal models and alterations that occur to the composition of the gastric microbiota in the presence of H. pylori infection that may augment the risk of developing gastric cancer.
authors: Division of Gastroenterology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN, USA.
authors: Lydia E
authors: LE
authors: Wroblewski
authors: Division of Gastroenterology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN, USA. richard.peek@vanderbilt.edu.
authors: Richard M
authors: RM
authors: Peek
mesh_terms: D000818:Animals; D005753:Gastric Mucosa / Q000378:metabolism; D000069196:Gastrointestinal Microbiome / Q000502:physiology*; D020022:Genetic Predisposition to Disease / Q000235:genetics; D016481:Helicobacter Infections / Q000235:genetics / Q000382:microbiology* / Q000473:pathology; D016480:Helicobacter pylori / Q000472:pathogenicity / Q000502:physiology*; D054884:Host-Pathogen Interactions; D006801:Humans; D013270:Stomach / Q000382:microbiology* / Q000473:pathology; D013274:Stomach Neoplasms / Q000235:genetics / Q000382:microbiology* / Q000473:pathology; D014774:Virulence
keywords: Firmicutes; Gastric adenocarcinoma; Helicobacter pylori; Microbiota; Mongolian gerbil; Pyrosequencing