title: Primary immunodeficiencies in Chile evaluated through ICD-10 coded hospital admissions.
abstract: BACKGROUND
  The epidemiology and hospitalisation trends of primary immunodeficiency (PID) in Chile are unknown. We aimed to evaluate hospitalisation trends and demographic characteristics of PID admissions in Chile.
  
  
  METHODS
  PID admissions between 2001 and 2010 (ICD-10 codes D70.0, D70.4, D71, 72.0, D76.1, D80-D84, E70.3, G11.3) were reviewed using national hospital discharge databases.
  
  
  RESULTS
  During the study period, 5486 admissions due to PID were registered (0.03% of total). 58.5% of patients were male and 66.3% were under 18 years. Median length of stay was one day (range 1-403 days). The most frequent diagnoses were hypogammaglobulinaemia (27.6%), unspecified immunodeficiency (21.9%), haemophagocytic lymphohystiocytosis (18.3%) and common variable immunodeficiency (11.2%). There was a significant increase in PID admission rate and in one-day hospitalisations during this period (β=0.2; P=0.001 and β=33; P≤0.001, respectively), however no significant variation was found for longer admissions (β=4.8; P=0.175). The increasing trend in PID admission rate was significant in patients with private, but not public insurance (β=0.53; P≤0.001 vs. β=0.08; P=0.079, respectively).
  
  
  CONCLUSIONS
  We report an increasing trend in admissions due to PID in Chile over a 10-year period. Increase is mainly due to short hospitalisations, possibly accounting for improvements in IVIG access. Higher admission rates in patients with private vs. public insurance suggest socioeconomic disparities in access to PID treatment. ICD-10 coded hospitalisation databases may be useful to determine hospitalisation trends and demographic characteristics of PID admissions worldwide.
authors: Department of Pediatrics, Faculty of Medicine, Universidad de Chile, Santiago de Chile, Chile; Allergy, Immunology and Rheumatology Unit, Hospital Dr. Roberto del Río, Independencia, Región Metropolitana, Santiago de Chile, Chile.
authors: C
authors: C
authors: Poli
authors: Department of Pediatric Infectious Diseases and Immunology, School of Medicine, Pontificia Universidad Católica de Chile, Santiago de Chile, Chile; Millennium Institute on Immunology and Immunotherapy, School of Medicine, Pontificia Universidad Católica de Chile, Santiago de Chile, Chile.
authors: R
authors: R
authors: Hoyos-Bachiloglu
authors: Department of Pediatric Infectious Diseases and Immunology, School of Medicine, Pontificia Universidad Católica de Chile, Santiago de Chile, Chile; Millennium Institute on Immunology and Immunotherapy, School of Medicine, Pontificia Universidad Católica de Chile, Santiago de Chile, Chile. Electronic address: arturobor@med.puc.cl.
authors: A
authors: A
authors: Borzutzky
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D002677:Chile / Q000453:epidemiology; D005260:Female; D006760:Hospitalization; D006801:Humans; D007153:Immunologic Deficiency Syndromes / Q000145:classification / Q000453:epidemiology*; D007223:Infant; D007231:Infant, Newborn; D038801:International Classification of Diseases; D007902:Length of Stay / Q000706:statistics & numerical data; D008297:Male; D012959:Socioeconomic Factors; D013997:Time Factors; D055815:Young Adult
keywords: Chile; Hospitalisations; ICD-10; Intravenous immunoglobulin; Primary immunodeficiency