title: Renal Papillary Necrosis Caused by Protein C Deficiency Leading to Recurrent Hydronephrosis.
abstract: A patient with history of a solitary functioning kidney and protein C deficiency (PCD) presented with recurrent severe hydronephrosis causing acute kidney injury upon chronic kidney disease. Work-up with endoscopic evaluation revealed renal papillary necrosis (RPN) and sloughed renal papillae to be the true cause of the recurrent obstruction. Pathologic evaluation of the sloughed tissue confirmed the diagnosis of RPN. This is the first case reported in the literature illustrating the unique presentation of RPN in the setting of PCD.
authors: Department of Urology, Mount Sinai Health System , New York, New York.
authors: Rohit Kumar
authors: RK
authors: Chugh
authors: Department of Urology, Mount Sinai Health System , New York, New York.
authors: Vincent
authors: V
authors: Olorunnisomo
authors: Department of Pathology, Mount Sinai Health System , New York, New York.
authors: Evan James
authors: EJ
authors: Fowle
authors: Department of Pathology, Mount Sinai Health System , New York, New York.
authors: Ippolito
authors: I
authors: Modica
authors: Department of Nephrology, Mount Sinai Health System , New York, New York.
authors: Ira
authors: I
authors: Meisels
authors: Department of Urology, Mount Sinai Health System , New York, New York.
authors: Mantu
authors: M
authors: Gupta