title: Mild photothermal therapy/photodynamic therapy/chemotherapy of breast cancer by Lyp-1 modified Docetaxel/IR820 Co-loaded micelles.
abstract: Patients suffering from cancer have benefited from combination therapy. Nanocarriers are the ideal candidates for combination therapy. In this study, we constructed docetaxel (DTX) loaded micellar nanomedicines co-loaded with near infrared (NIR) dye-IR820 for photothermal therapy (PTT)/photodynamic therapy (PDT)/chemotherapy of breast cancer. Lyp-1, a tumor homing peptide, was introduced into the nanosystems to construct the active targeting nanomedicine. In order to deliver IR820 to the tumor site and overcome its short lifetime in vivo, a PEI derivative-PCL-g-PEI was introduced. IR820 with negative charge was formed stable static interaction with the amine groups, meanwhile, the absorption of IR820 in the NIR region was weakened. It indicated that the nanosystem constructed in this study may provide an alternative candidate for mild PTT. By the evaluation of the photothermal conversion in vivo, we can confirm that IR820 has been successfully delivered and effectively accumulated in the tumor site. Furthermore, the tumor cells targeting and anticancer performances of this nanosystem have been studied in vitro and in vivo. The results demonstrated Lyp-1 modification has enhanced the tumor targeting delivery of DTX and IR820. By combining PTT and PDT, DTX nanomedicine efficiently inhibited the growth and metastasis of breast cancer in mice. This nanosystem is a promising candidate for combination therapy of breast cancer.
authors: State Key Laboratory of Biotherapy, Collaborative Innovation Center of Biotherapy, West China Hospital, Sichuan University, Sichuan, China.
authors: WenTing
authors: W
authors: Li
authors: State Key Laboratory of Biotherapy, Collaborative Innovation Center of Biotherapy, West China Hospital, Sichuan University, Sichuan, China.
authors: JinRong
authors: J
authors: Peng
authors: State Key Laboratory of Biotherapy, Collaborative Innovation Center of Biotherapy, West China Hospital, Sichuan University, Sichuan, China.
authors: LiWei
authors: L
authors: Tan
authors: State Key Laboratory of Biotherapy, Collaborative Innovation Center of Biotherapy, West China Hospital, Sichuan University, Sichuan, China.
authors: Jing
authors: J
authors: Wu
authors: State Key Laboratory of Biotherapy, Collaborative Innovation Center of Biotherapy, West China Hospital, Sichuan University, Sichuan, China.
authors: Kun
authors: K
authors: Shi
authors: State Key Laboratory of Biotherapy, Collaborative Innovation Center of Biotherapy, West China Hospital, Sichuan University, Sichuan, China.
authors: Ying
authors: Y
authors: Qu
authors: State Key Laboratory of Biotherapy, Collaborative Innovation Center of Biotherapy, West China Hospital, Sichuan University, Sichuan, China.
authors: XiaWei
authors: X
authors: Wei
authors: State Key Laboratory of Biotherapy, Collaborative Innovation Center of Biotherapy, West China Hospital, Sichuan University, Sichuan, China. Electronic address: anderson-qian@163.com.
authors: ZhiYong
authors: Z
authors: Qian
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents; D001943:Breast Neoplasms / Q000378:metabolism* / Q000473:pathology / Q000628:therapy*; D003131:Combined Modality Therapy / Q000379:methods; D000077143:Docetaxel; D004655:Emulsions / Q000737:chemistry; D005260:Female; D006979:Hyperthermia, Induced / Q000379:methods; D007208:Indocyanine Green / Q000008:administration & dosage / Q000031:analogs & derivatives*; D007259:Infrared Rays / Q000627:therapeutic use; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D008823:Micelles; D058990:Molecular Targeted Therapy / Q000379:methods; D053769:Nanocapsules / Q000008:administration & dosage / Q000737:chemistry*; D010456:Peptides, Cyclic / Q000737:chemistry / Q000493:pharmacokinetics*; D010778:Photochemotherapy / Q000379:methods*; D017319:Photosensitizing Agents / Q000008:administration & dosage; D010789:Phototherapy / Q000379:methods; D043823:Taxoids / Q000008:administration & dosage*; D016896:Treatment Outcome
chemical_list: D000970:Antineoplastic Agents; D004655:Emulsions; C541053:IR 820; C533969:LyP-1 peptide; D008823:Micelles; D053769:Nanocapsules; D010456:Peptides, Cyclic; D017319:Photosensitizing Agents; D043823:Taxoids; D000077143:Docetaxel; D007208:Indocyanine Green
keywords: Cancer therapy; Chemotherapy; Micelle; Photodynamic therapy; Photothermal therapy