title: The Use of Tools, Modelling Methods, Data Types, and Endpoints in Systems Medicine: A Survey on Projects of the German e:Med-Programme.
abstract: Systems medicine is the consequent continuation of research efforts on the road to an individualized medicine. Thereby, systems medicine tries to offer a holistic view on the patient by combining different data sources to highlight different perspectives on the patient's health. Our research question was to identify the main data types, modelling methods, analysis tools, and endpoints currently used and studied in systems medicine. Therefore, we conducted a survey on projects with a systems medicine background. Fifty participants completed this survey. The results of the survey were analyzed using histograms and cross tables, and finally compared to results of a former literature review with the same research focus. The data types reported in this survey were widely diversified. As expected, genomic and phenotype data were used most frequently. In contrast, environmental and behavioral data were rarely used in the projects. Overall, the cross tables of the data types in the survey and the literature review showed overlapping results.
authors: Institute of Medical Biometry and Informatics, Heidelberg University, Heidelberg, Germany.
authors: Matthias
authors: M
authors: Gietzelt
authors: German Cancer Research Center (DKFZ), Heidelberg, Germany.
authors: Thomas
authors: T
authors: Höfer
authors: Institute of Medical Biometry and Informatics, Heidelberg University, Heidelberg, Germany.
authors: Petra
authors: P
authors: Knaup-Gregori
authors: Integrated Research and Treatment Center, Center for Sepsis Control and Care (CSCC), Jena University Hospital, Jena, Germany.
authors: Rainer
authors: R
authors: König
authors: Institute of Medical Biometry and Informatics, Heidelberg University, Heidelberg, Germany.
authors: Martin
authors: M
authors: Löpprich
authors: Integrated Research and Treatment Center, Center for Sepsis Control and Care (CSCC), Jena University Hospital, Jena, Germany.
authors: Alexandra
authors: A
authors: Poos
authors: Institute of Medical Biometry and Informatics, Heidelberg University, Heidelberg, Germany.
authors: Matthias
authors: M
authors: Ganzinger
mesh_terms: D003695:Delivery of Health Care; D005858:Germany; D006801:Humans; D011795:Surveys and Questionnaires; D013597:Systems Analysis; D017216:Telemedicine