title: Genetic association of COL1A1 polymorphisms with high myopia in Asian population: a Meta-analysis.
abstract: OBJECTIVE
  To comprehensively evaluate the potential association of COL1A1 polymorphisms with high myopia by a systematic review and Meta-analysis.
  
  
  METHODS
  All association studies on COL1A1 and high myopia reported up to June 10, 2014 in PubMed, Embase, Web of Science, and the Chinese Biomedical Database were retrieved. Odds ratios (ORs) and 95% confidence intervals (95% CIs) were analyzed for single-nucleotide polymorphisms (SNPs) using fixed- and random- effects models according to between-study heterogeneity. Publication bias analyses were conducted by Egger's test.
  
  
  RESULTS
  A total of four studies from reported papers were included in this analysis. The Meta-analyses for COL1A1 rs2075555, composed of 2304 high myopia patients and 2272 controls, failed to detect any significant association with high myopia. A total of 971 cases and 649 controls were tested for COL1A1 rs2269336. The association of COL1A1 rs2269336 with high myopia was observed in recessive model (CC vs CG+GG, P=0.03) and in heterozygous model (CG vs GG, P=0.04), but not in other models.
  
  
  CONCLUSIONS
  This Meta-analysis shows that COL1A1 rs2269336 (CC vs CG+GG) affects individual susceptibility to high myopia, whereas there is no association detected between SNPs rs2075555 and high myopia. Given the limited sample size, further investigations including more ethnic groups are required to validate the association.
authors: Sichuan Provincial Key Laboratory for Disease Gene Study, Hospital of University of Electronic Science and Technology of China and Sichuan Provincial People's Hospital, Chengdu 610072, Sichuan Province, China; School of Medicine, University of Electronic Science and Technology of China, Chengdu 610072, Sichuan Province, China.
authors: Bo
authors: B
authors: Gong
authors: School of Medicine, University of Electronic Science and Technology of China, Chengdu 610072, Sichuan Province, China; Department of Ophthalmology, Hospital of University of Electronic Science and Technology of China and Sichuan Provincial People's Hospital, Chengdu 610072, Sichuan Province, China.
authors: Chao
authors: C
authors: Qu
authors: Department of Ophthalmology, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China.
authors: Xiao-Fang
authors: XF
authors: Huang
authors: Sichuan Provincial Key Laboratory for Disease Gene Study, Hospital of University of Electronic Science and Technology of China and Sichuan Provincial People's Hospital, Chengdu 610072, Sichuan Province, China.
authors: Zi-Meng
authors: ZM
authors: Ye
authors: Sichuan Provincial Key Laboratory for Disease Gene Study, Hospital of University of Electronic Science and Technology of China and Sichuan Provincial People's Hospital, Chengdu 610072, Sichuan Province, China; School of Medicine, University of Electronic Science and Technology of China, Chengdu 610072, Sichuan Province, China.
authors: Ding-Ding
authors: DD
authors: Zhang
authors: Sichuan Provincial Key Laboratory for Disease Gene Study, Hospital of University of Electronic Science and Technology of China and Sichuan Provincial People's Hospital, Chengdu 610072, Sichuan Province, China; School of Medicine, University of Electronic Science and Technology of China, Chengdu 610072, Sichuan Province, China.
authors: Yi
authors: Y
authors: Shi
authors: Department of Microbiology and Immunology, North Sichuan Medical College, Nanchong 637000, Sichuan Province, China.
authors: Rong
authors: R
authors: Chen
authors: School of Medicine, University of Electronic Science and Technology of China, Chengdu 610072, Sichuan Province, China; Health Management Center, Hospital of University of Electronic Science and Technology of China and Sichuan Provincial People's Hospital, Chengdu 610072, Sichuan Province, China.
authors: Yu-Ping
authors: YP
authors: Liu
authors: Sichuan Provincial Key Laboratory for Disease Gene Study, Hospital of University of Electronic Science and Technology of China and Sichuan Provincial People's Hospital, Chengdu 610072, Sichuan Province, China; School of Medicine, University of Electronic Science and Technology of China, Chengdu 610072, Sichuan Province, China; Health Management Center, Hospital of University of Electronic Science and Technology of China and Sichuan Provincial People's Hospital, Chengdu 610072, Sichuan Province, China.
authors: Ping
authors: P
authors: Shuai
keywords: COL1A1; Meta-analysis; association; high myopia