title: Adherence of Staphylococcus aureus to Dyneema Purity® Patches and to Clinically Used Cardiovascular Prostheses.
abstract: Various materials that are used for vascular and heart valve prostheses carry drawbacks: some require anticoagulant drugs or have moderate durability; others are not suitable for endovascular treatment. These prostheses are associated with bacterial infections. A material potentially suitable for prostheses is Dyneema Purity®, made of ultra-high-molecular-weight polyethylene. Dyneema Purity® fibers are very thin, flexible, resistant to fatigue and abrasion, and have high strength. S. aureus adherence to Dyneema Purity® was tested and compared with currently used cardiovascular prostheses. We compared adhesion of S. aureus to Dyneema Purity® (1 membrane-based and 1 yarn-composed patch) with 5 clinically used yarn-composed polyester and membrane-based expanded polytetrafluoroethylene patches. Patches were contaminated with S. aureus bacteria and bacterial adherence was quantified. S. aureus adherence was also visualized in flow conditions. Overall, bacterial adherence was higher on yarn-composed prosthesis materials, with a rough surface, than on the membrane-based materials, with a smooth surface. Adherence to Dyneema Purity® materials was non-inferior to the currently used materials. Therefore, patches of Dyneema Purity® might be attractive for use in cardiovascular applications such as catheter-based heart valves and endovascular prostheses by their good mechanical properties combined with their noninferiority regarding bacterial adhesion.
authors: Department of Experimental Cardiology, UMC Utrecht, Utrecht, the Netherlands.
authors: Amir
authors: A
authors: Basir
authors: Department of Experimental Cardiology, UMC Utrecht, Utrecht, the Netherlands.
authors: Paul
authors: P
authors: Gründeman
authors: Department of Vascular Surgery, UMC Utrecht, Utrecht, the Netherlands.
authors: Frans
authors: F
authors: Moll
authors: Department of Vascular Surgery, UMC Utrecht, Utrecht, the Netherlands.
authors: Joost
authors: J
authors: van Herwaarden
authors: Department of Experimental Cardiology, UMC Utrecht, Utrecht, the Netherlands.
authors: Gerard
authors: G
authors: Pasterkamp
authors: Department of Medical Microbiology, UMC Utrecht, Utrecht, The Netherlands.|Laboratory of Phytopathology, Wageningen University, Wageningen, The Netherlands.
authors: Reindert
authors: http://orcid.org/0000-0003-0049-3768
authors: R
authors: Nijland
mesh_terms: D001422:Bacterial Adhesion; D001807:Blood Vessel Prosthesis / Q000382:microbiology*; D015169:Colony Count, Microbial; D006801:Humans; D013211:Staphylococcus aureus / Q000502:physiology*