title: Characterizing Contact Lens-Related Corneal Infiltrates: A Pilot Study.
abstract: OBJECTIVE
  To document the time course and resolution of contact lens-related corneal infiltrative events (CIEs) comparing slit-lamp images with anterior segment ocular coherence tomography (AS-OCT) images.
  
  
  METHODS
  Six silicone hydrogel (SiHy) soft contact lens (SCL) wearers presenting with newly diagnosed symptomatic CIEs were monitored with slit-lamp images, detailed drawings, and AS-OCT until the resolution of the CIE. A final follow-up visit was completed 4 weeks after CIE resolution to determine whether scar formation was present. Positive controls were 2 SiHy SCL wearers with established (inactive) corneal scars, and negative controls were 2 SiHy SCL wearers with clear corneas. High- and low-contrast logMAR visual acuities were measured, and subjective symptom questionnaires were completed at all visits.
  
  
  RESULTS
  Clinical signs, vision, and symptoms improved in tandem with the resolution of the CIEs as measured by imaging methods. Calibrated measures of infiltrate width from a slit-lamp biomicroscope appear to be similar to calibrated images from AS-OCT.
  
  
  CONCLUSIONS
  Although further studies are needed to develop standardized procedures, AS-OCT can be a useful tool to characterize the development, progression, and resolution of corneal infiltrates as an objective measure of resolution and scar formation.
authors: *Johnson and Johnson Vision Care, Inc., Jacksonville, FL;†Indiana University School of Optometry, Bloomington, IN; and‡Private Consultant, Atlanta, GA.
authors: Meredith E
authors: ME
authors: Jansen
authors: Ping
authors: P
authors: Situ
authors: Carolyn G
authors: CG
authors: Begley
authors: Danielle
authors: D
authors: Boree
authors: Robin L
authors: RL
authors: Chalmers
authors: Kathrine
authors: K
authors: Osborn Lorenz
authors: Tawnya
authors: T
authors: Wilson
mesh_terms: D003263:Contact Lenses, Hydrophilic / Q000009:adverse effects*; D018450:Disease Progression; D005260:Female; D015590:Fluorophotometry; D005500:Follow-Up Studies; D006801:Humans; D007634:Keratitis / Q000175:diagnosis* / Q000209:etiology* / Q000503:physiopathology / Q000628:therapy; D007962:Leukocytes / Q000473:pathology*; D008297:Male; D010865:Pilot Projects; D011446:Prospective Studies; D012307:Risk Factors; D066167:Slit Lamp; D011795:Surveys and Questionnaires; D041623:Tomography, Optical Coherence; D014792:Visual Acuity / Q000502:physiology; D055815:Young Adult