title: Reaction to anti-D immunoglobulin - can we manage it?
abstract: Approximately one in six women are blood group RhD negative and are offered anti-D immunoglobulin prophylaxis to prevent sensitization and decrease the risk of haemolytic disease of the newborn in subsequent pregnancies. It has been thought that anti-D is harmless, but there is a risk of anaphylaxis. We describe a case of a woman with a possible immunological reaction to anti-D in her first pregnancy. A multidisciplinary team managed her second pregnancy, offering her evidence-based advice, where available, so that she could reach an informed decision regarding administration of anti-D or not. Women value individual tailored information rather than a 'one-size-fits-all' approach.
authors: Southmead Hospital, Southmead Road, Westbury on Trym, Bristol BS10 5NB.
authors: Katherine
authors: K
authors: O'Brien
authors: Southmead Hospital, Southmead Road, Westbury on Trym, Bristol BS10 5NB; North Academy, University of Bristol.
authors: Dimitrios
authors: D
authors: Siassakos
authors: NHS Blood and Transplant, National Blood Service, 1st Floor, 2440 The Quadrant, Aztec West, Almodsbury, Bristol BS32 4AQ.
authors: Janet
authors: J
authors: Birchall
authors: Southmead Hospital, Southmead Road, Westbury on Trym, Bristol BS10 5NB.
authors: Mark
authors: M
authors: Gompels
authors: Taunton & Somerset NHS Foundation Trust , Musgrove Park Hospital , Somerset, Taunton TA 15DE , UK.
authors: Sarah
authors: S
authors: Allford
authors: Taunton & Somerset NHS Foundation Trust , Musgrove Park Hospital , Somerset, Taunton TA 15DE , UK.
authors: Ken
authors: K
authors: Bidgood
keywords: anaphylaxis; anti-D; pregnancy