title: Angiogenin Defines Heterogeneity at the Core of the Hematopoietic Niche.
abstract: Successful hematopoietic regeneration demands preservation of stemness while enabling expansion and differentiation into blood lineages. Now, Silberstein et al. (2016) and Goncalves et al. (2016) identify a ribonuclease secreted by proximal niche cells that simultaneously drives quiescence of HSCs and proliferation of myeloid progenitors and dramatically enhances hematopoietic recovery after HSC transplantation.
authors: Department of Cell and Developmental Biology, Fundación Centro Nacional de Investigaciones Cardiovasculares (CNIC) Carlos III, 28029 Madrid, Spain.
authors: Marianna
authors: M
authors: Di Scala
authors: Department of Cell and Developmental Biology, Fundación Centro Nacional de Investigaciones Cardiovasculares (CNIC) Carlos III, 28029 Madrid, Spain; Institute for Cardiovascular Prevention, Ludwig-Maximilians University, 80336 Munich, Germany. Electronic address: ahidalgo@cnic.es.
authors: Andrés
authors: A
authors: Hidalgo
mesh_terms: D002454:Cell Differentiation; D006412:Hematopoietic Stem Cells; D006801:Humans; D012038:Regeneration; D055153:Stem Cell Niche