title: EQ-5D Health Utility Scores: Data from a Comprehensive Canadian Cancer Centre.
abstract: To improve the precision of health economics analyses in oncology, reference datasets of health utility (HU) scores are needed from cancer survivors across different disease sites. These data are particularly sparse amongst Canadian survivors.
  
  
  
  A survey was completed by 1759 ambulatory cancer survivors at the Princess Margaret Cancer Centre which contained demographic questions and the EuroQol-5D (EQ-5D) instrument. Clinical information was abstracted from electronic records and HU scores were calculated using Canadian health state valuations. Construct validity was assessed through correlation of HU and visual analog scale (VAS) scores (Spearman) and by comparing HU scores between performance status groups (effect size). The influence of socio-demographic clinical variables on HU was analyzed by non-parametric between-group comparisons and multiple linear regression.
  
  
  
  Mean EQ-5D HU scores were derived for 26 cancers. Among all survivors, the mean ± standard error of the mean EQ-5D utility score was 0.81 ± 0.004. Scores varied significantly by performance status (p < 0.0001) and correlated with VAS (Spearman r = 0.61). The cancer sites with the lowest mean HU scores were acute lymphoblastic leukemia (0.70 ± 0.03) and pancreatic cancer (0.76 ± 0.03); testicular cancer (0.89 ± 0.02) and chronic lymphocytic leukemia (0.90 ± 0.05) had the highest mean scores. A multiple regression model showed that scores were influenced by disease site (p < 0.001), education level (p < 0.001), partner status (p < 0.001), disease extent (p = 0.0029), and type of most recent treatment (p = 0.0061).
  
  
  
  This work represents the first set of HU scores for numerous cancer sites derived using Canadian preference weights. The dataset demonstrated construct validity and HU scores varied by general socio-demographic and clinical parameters.
authors: Princess Margaret Cancer Centre, Ontario Cancer Institute, 610 University Ave., Room 7-124, Toronto, ON, M5G2M9, Canada.
authors: Hiten
authors: H
authors: Naik
authors: Princess Margaret Cancer Centre, Ontario Cancer Institute, 610 University Ave., Room 7-124, Toronto, ON, M5G2M9, Canada.
authors: Doris
authors: D
authors: Howell
authors: Biostatistics, Ontario Cancer Institute, Princess Margaret Cancer Centre, Toronto, ON, Canada.
authors: Susie
authors: S
authors: Su
authors: Biostatistics, Ontario Cancer Institute, Princess Margaret Cancer Centre, Toronto, ON, Canada.
authors: Xin
authors: X
authors: Qiu
authors: Princess Margaret Cancer Centre, Ontario Cancer Institute, 610 University Ave., Room 7-124, Toronto, ON, M5G2M9, Canada.
authors: M Catherine
authors: MC
authors: Brown
authors: Princess Margaret Cancer Centre, Ontario Cancer Institute, 610 University Ave., Room 7-124, Toronto, ON, M5G2M9, Canada.
authors: Ashlee
authors: A
authors: Vennettilli
authors: Princess Margaret Cancer Centre, Ontario Cancer Institute, 610 University Ave., Room 7-124, Toronto, ON, M5G2M9, Canada.
authors: Margaret
authors: M
authors: Irwin
authors: Princess Margaret Cancer Centre, Ontario Cancer Institute, 610 University Ave., Room 7-124, Toronto, ON, M5G2M9, Canada.
authors: Vivien
authors: V
authors: Pat
authors: Princess Margaret Cancer Centre, Ontario Cancer Institute, 610 University Ave., Room 7-124, Toronto, ON, M5G2M9, Canada.
authors: Hannah
authors: H
authors: Solomon
authors: Princess Margaret Cancer Centre, Ontario Cancer Institute, 610 University Ave., Room 7-124, Toronto, ON, M5G2M9, Canada.
authors: Tian
authors: T
authors: Wang
authors: Princess Margaret Cancer Centre, Ontario Cancer Institute, 610 University Ave., Room 7-124, Toronto, ON, M5G2M9, Canada.
authors: Henrique
authors: H
authors: Hon
authors: Princess Margaret Cancer Centre, Ontario Cancer Institute, 610 University Ave., Room 7-124, Toronto, ON, M5G2M9, Canada.
authors: Lawson
authors: L
authors: Eng
authors: Princess Margaret Cancer Centre, Ontario Cancer Institute, 610 University Ave., Room 7-124, Toronto, ON, M5G2M9, Canada.
authors: Mary
authors: M
authors: Mahler
authors: Princess Margaret Cancer Centre, Ontario Cancer Institute, 610 University Ave., Room 7-124, Toronto, ON, M5G2M9, Canada.
authors: Henry
authors: H
authors: Thai
authors: Princess Margaret Cancer Centre, Ontario Cancer Institute, 610 University Ave., Room 7-124, Toronto, ON, M5G2M9, Canada.
authors: Valerie
authors: V
authors: Ho
authors: Biostatistics, Ontario Cancer Institute, Princess Margaret Cancer Centre, Toronto, ON, Canada.
authors: Wei
authors: W
authors: Xu
authors: Health Outcomes and PharmacoEconomic (HOPE) Research Centre, Sunnybrook Research Institute, Toronto, ON, Canada.
authors: Soo Jin
authors: SJ
authors: Seung
authors: Health Outcomes and PharmacoEconomic (HOPE) Research Centre, Sunnybrook Research Institute, Toronto, ON, Canada.|Department of Pharmacology, University of Toronto, Toronto, ON, Canada.|Cancer Care Ontario, Toronto, ON, Canada.
authors: Nicole
authors: N
authors: Mittmann
authors: Princess Margaret Cancer Centre, Ontario Cancer Institute, 610 University Ave., Room 7-124, Toronto, ON, M5G2M9, Canada. geoffrey.liu@uhn.ca.
authors: Geoffrey
authors: G
authors: Liu
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002170:Canada; D002173:Cancer Care Facilities / Q000706:statistics & numerical data*; D000073116:Cancer Survivors / Q000706:statistics & numerical data*; D005260:Female; D006296:Health Services / Q000706:statistics & numerical data*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000628:therapy*; D011788:Quality of Life; D012959:Socioeconomic Factors; D011795:Surveys and Questionnaires