title: miR-19a/b modulates lung cancer cells metastasis through suppression of MXD1 expression.
abstract: Increasing evidence has shown that microRNA (miRNA) is extensively involved in the pathophysiology of lung cancer. Microarray data demonstrated the increasing levels of miR-19a in the peripheral blood from patients suffering from lung cancer, which is closely associated with poor prognosis of lung cancer. However, the underlying molecular mechanism of miR-19a remains to be determined. The results of the present study showed a higher expression of miR-19a compared with normal bronchial epithelial cells. Furthermore, lentivirus vectors were constructed to establish cell lines that overexpressed and knocked out miR-19a in order to study the role of miR-19a on the metastasis and proliferation of lung cancer cells. Investigation into the underlying mechanism of miR-19a, revealed that MXD1 may be the key gene targeting miR-19a, participating in the process of proliferation and metastasis of lung cancer cells.
authors: Department of Respiratory Medicine, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei 050012, P.R. China.
authors: Wenxia
authors: W
authors: Hu
authors: Department of Respiratory Medicine, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei 050012, P.R. China.
authors: Pule
authors: P
authors: Jin
authors: Department of Respiratory Medicine, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei 050012, P.R. China.
authors: Cuimin
authors: C
authors: Ding
authors: Department of Oncology, Hebei Medical University, Shijiazhuang, Hebei 050017, P.R. China.
authors: Wei
authors: W
authors: Liu
keywords: MXD1; lung cancer; metastasis; microRNA