title: Regulatory roles of B cells in infectious diseases.
abstract: B lymphocytes provide essential mechanisms of protection against infectious diseases. The secretion of specific antibodies by long-lived plasma cells is thought to account for the improved resistance afforded by most successful vaccines against pathogens. Accordingly, a goal in vaccine development is to induce potent B cell responses in order to drive the efficient formation of long-lived antibody-secreting cells. However, the roles of activated B cells are complex in infectious diseases. It was recently observed that activated B cells could also negatively regulate host defence mechanisms, both during primary infection and, after vaccination, upon secondary challenge, via mechanisms involving their production of the anti-inflammatory cytokines interleukin (IL)-10 and IL-35. Remarkably, the B cells expressing IL-10 and IL-35 in vivo were distinct subsets of IgMhiCD19+CD138hi antibody-secreting cells. A better understanding of the diverse roles of these distinct antibody-secreting cell subsets in immunity and immunological memory, as well as of the signals controlling their generation, might help the rational development of better prophylactic and therapeutic vaccines.
authors: Inst.Necker-Enfants Malades (INEM), INSERM U1151-CNRS UMR 8253, Paris; Univ.Paris Descartes, Sorbonne Paris Cité; Assistance Publique-Hôpitaux de Paris (AP-HP), Hôp.Necker Enfants Malades, Paris, France; Deutsches Rheuma-Forschungszentrum, Berlin, Germany.
authors: Simon
authors: S
authors: Fillatreau
mesh_terms: D000818:Animals; D000906:Antibodies / Q000276:immunology / Q000378:metabolism; D060151:B-Lymphocytes, Regulatory / Q000276:immunology* / Q000378:metabolism; D003141:Communicable Diseases / Q000276:immunology* / Q000378:metabolism / Q000628:therapy; D016207:Cytokines / Q000276:immunology / Q000378:metabolism; D054884:Host-Pathogen Interactions; D006801:Humans; D056724:Immunity, Humoral; D007156:Immunologic Memory; D007167:Immunotherapy / Q000379:methods; D008213:Lymphocyte Activation; D010641:Phenotype; D014611:Vaccination; D014612:Vaccines / Q000276:immunology / Q000627:therapeutic use
chemical_list: D000906:Antibodies; D016207:Cytokines; D014612:Vaccines