title: Divergent Synthesis of Hydro-γ-Carbolines and Multisubstituted Indoles through Grob Fragmentation/Mannich Cyclization.
abstract: A distinct strategy for the divergent synthesis of hydro-γ-carbolines and multisubstituted indoles is reported. The stereochemical outcomes and a control experiment indicate that the reactions likely proceed through Grob fragmentation/Mannich cyclization rather than a concerted aza-pinacol rearrangement.
authors: School of Pharmaceutical Sciences, Tsinghua University, Beijing, 100084, China.
authors: Long
authors: L
authors: Jiang
authors: School of Pharmaceutical Sciences, Tsinghua University, Beijing, 100084, China.
authors: Yuanyuan
authors: Y
authors: Yu
authors: School of Pharmaceutical Sciences, Tsinghua University, Beijing, 100084, China.
authors: Guang
authors: G
authors: Li
authors: School of Pharmaceutical Sciences, Tsinghua University, Beijing, 100084, China. zuliansuo@biomed.tsinghua.edu.cn.
authors: Liansuo
authors: L
authors: Zu
keywords: Grob fragmentation; Mannich cyclization; aza-pinacol rearrangement; hydrocarbolines; indoles