title: Clinical and pathological analysis of IgA nephropathy with chronic renal failure.
abstract: OBJECTIVE
  To investigative clinical and pathological characteristics of IgA nephropathy with chronic renal failure.
  
  
  METHODS
  Clinical and pathological findings from 65 cases of IgA nephropathy with chronic renal failure were reviewed. Pathological characteristics of all the cases were analyzed according to WHO definition and Oxford Classification. Evaluating the severity of pathological lesions by the Katafuchi R semiquantitative scoring system, and analyzing their relationship with clinical indexes of renal function.
  
  
  RESULTS
  Of all 65 cases the male and female ratio was 1.4, and the mean age was 37 ± 13 years old. Levels of systolic pressure, mean arterial pressure (MAP), blood urea nitrogen (BUN), serum creatinine (Scr), uric acid (UA), album (Alb), serum IgG and 24 h urinary protein were related with eGRF level (p < 0.05, respectively). The most common pathological type was proliferative sclerosis glomerulonephritis (PSGN) and M1S1E0T0 according to WHO definition and Oxford Classification, respectively, and most of the 65 cases had glomerulosclerosis. Simple IgA deposition was the most common immunopathologic type. Of all the cases, 44.6% accompanied with C3 while 4.6% with C1q. Further analysis revealed there were no relationships between severity of pathological lesion and levels of clinical indexes (Scr and eGRF) (p > 0.05).
  
  
  CONCLUSIONS
  IgA nephropathy with chronic renal failure usually occurred in young adults, and it had severe clinical condition and pathological changes, while there was no significant relationship between them.
authors: a Department of Nephrology , Suzhou Municipal Hospital , Suzhou , Jiangsu , China.
authors: Yuyuan
authors: Y
authors: Liu
authors: a Department of Nephrology , Suzhou Municipal Hospital , Suzhou , Jiangsu , China.
authors: Qinfeng
authors: Q
authors: Hu
authors: a Department of Nephrology , Suzhou Municipal Hospital , Suzhou , Jiangsu , China.
authors: Ping
authors: P
authors: Shen
authors: a Department of Nephrology , Suzhou Municipal Hospital , Suzhou , Jiangsu , China.
authors: Li
authors: L
authors: Tang
authors: a Department of Nephrology , Suzhou Municipal Hospital , Suzhou , Jiangsu , China.
authors: Gang
authors: G
authors: Yuan
authors: a Department of Nephrology , Suzhou Municipal Hospital , Suzhou , Jiangsu , China.
authors: Yongmei
authors: Y
authors: Zhou
authors: a Department of Nephrology , Suzhou Municipal Hospital , Suzhou , Jiangsu , China.
authors: Huaqi
authors: H
authors: Chai
mesh_terms: D000328:Adult; D001706:Biopsy; D001794:Blood Pressure / Q000502:physiology*; D001806:Blood Urea Nitrogen; D003404:Creatinine / Q000097:blood; D018450:Disease Progression; D005260:Female; D005500:Follow-Up Studies; D005922:Glomerulonephritis, IGA / Q000150:complications* / Q000175:diagnosis / Q000503:physiopathology; D006801:Humans; D007668:Kidney / Q000473:pathology*; D007676:Kidney Failure, Chronic / Q000175:diagnosis / Q000209:etiology* / Q000503:physiopathology; D008297:Male; D012189:Retrospective Studies; D014527:Uric Acid / Q000097:blood
chemical_list: D014527:Uric Acid; D003404:Creatinine
keywords: IgA nephropathy; chronic renal failure; clinical characteristic; pathological change