title: Diagnosis of prediabetes in cats: glucose concentration cut points for impaired fasting glucose and impaired glucose tolerance.
abstract: Diabetes is typically diagnosed in cats once clinical signs are evident. Diagnostic criteria for prediabetes in cats have not been defined. The objective of the study was to establish methodology and cut points for fasting and 2-h blood glucose concentrations in healthy client-owned senior cats (≥8 yr) using ear/paw samples and a portable glucose meter calibrated for feline blood. Of the 78 cats, 27 were ideal (body condition score [BCS] 4 or 5 of 9), 31 overweight (BCS 6 or 7), and 20 obese (BCS 8 or 9); 19 were Burmese and 59 non-Burmese. After an 18-24-h fast and an ear/paw blood glucose measurement using a portable glucose meter, glucose (0.5 g/kg bodyweight) was administered intravenous and blood glucose measured at 2 min and 2 h. Cut points for fasting and 2-h glucose concentrations were defined as the upper limits of 95% reference intervals using cats with BCS 4 or 5. The upper cut point for fasting glucose was 6.5 mmol/L. Of the overweight and obese cats, 1 (BCS 7) was above this cut point indicating evidence of impaired fasting glucose. The cut point for 2-h glucose was 9.8 mmol/L. A total of 7 cats (4 with BCS 8 or 9 including 1 Burmese; 3 with BCS 6 or 7, non-Burmese) were above this cut point and thus had evidence of impaired glucose tolerance. In conclusion, the methodology and cutpoints for diagnosis of prediabetes are defined for use in healthy cats 8 yr and older with a range of BCSs.
authors: The School of Veterinary Science, University of Queensland, Brisbane, Australia. Electronic address: m.reevejohnson@uq.edu.au.
authors: M K
authors: MK
authors: Reeve-Johnson
authors: The School of Veterinary Science, University of Queensland, Brisbane, Australia.
authors: J S
authors: JS
authors: Rand
authors: The School of Veterinary Science, University of Queensland, Brisbane, Australia.
authors: D
authors: D
authors: Vankan
authors: The School of Biomedical Sciences, University of Queensland, Brisbane, Australia.
authors: S T
authors: ST
authors: Anderson
authors: The Cat Clinic, Brisbane, Australia.
authors: R
authors: R
authors: Marshall
authors: The School of Veterinary Science, University of Queensland, Brisbane, Australia; Jemora Pty Ltd, PO Box 2277, Geelong, Australia.
authors: J M
authors: JM
authors: Morton
mesh_terms: D000818:Animals; D001786:Blood Glucose; D001824:Body Constitution; D002371:Cat Diseases / Q000175:diagnosis* / Q000235:genetics; D002415:Cats; D020022:Genetic Predisposition to Disease; D018149:Glucose Intolerance / Q000662:veterinary*; D005951:Glucose Tolerance Test / Q000662:veterinary; D011236:Prediabetic State / Q000175:diagnosis / Q000235:genetics / Q000662:veterinary*
chemical_list: D001786:Blood Glucose
keywords: Diabetes; Endocrinology; Glucose tolerance test; Hyperglycemia