title: Screening of Photosensitizers by Chemiluminescence Monitoring of Formation Dynamics of Singlet Oxygen during Photodynamic Therapy.
abstract: Finding an efficient photosensitizer is crucial in ensuring a therapeutic effect of photodynamic treatment. Currently, screening of photosensitizers during photodynamic therapy is achieved by evaluating the total yield of singlet oxygen (1O2), rather than monitoring the formation dynamics of1O2.1O2-based chemiluminescence (CL) is a suitable method to directly monitor the generated amount of1O2. Herein, the tetraphenylethene-sodium dodecyl sulfonate surfactant with aggregation-induced emission characteristics can remarkably amplify the intrinsic CL emission from1O2by integrating its micellar microenvironment with a CL energy acceptor effect in a cage-like structure. We present a new luminescence platform for the rapid screening of photosensitizers by monitoring the formation dynamics of1O2during photodynamic therapy. This study will not only be critical in optimizing the irradiation time during photodynamic therapy but also open a new door to the discovery of efficient photosensitizers.
authors: State Key Laboratory of Chemical Resource Engineering, Beijing University of Chemical Technology , Beijing 100029, China.
authors: Fengjuan
authors: F
authors: Zou
authors: State Key Laboratory of Chemical Resource Engineering, Beijing University of Chemical Technology , Beijing 100029, China.
authors: Wenjuan
authors: W
authors: Zhou
authors: State Key Laboratory of Chemical Resource Engineering, Beijing University of Chemical Technology , Beijing 100029, China.
authors: Weijiang
authors: W
authors: Guan
authors: State Key Laboratory of Chemical Resource Engineering, Beijing University of Chemical Technology , Beijing 100029, China.
authors: Chao
authors: C
authors: Lu
authors: Department of Chemistry, The Hong Kong University of Science and Technology , Clear Water Bay, Kowloon, Hong Kong.
authors: Ben Zhong
authors: BZ
authors: Tang
mesh_terms: D049449:Luminescence; D010778:Photochemotherapy; D017319:Photosensitizing Agents / Q000737:chemistry*; D011789:Quantum Theory; D026082:Singlet Oxygen / Q000032:analysis* / Q000737:chemistry*; D012967:Sodium Dodecyl Sulfate / Q000737:chemistry; D013267:Stilbenes / Q000737:chemistry; D013501:Surface-Active Agents / Q000737:chemistry
chemical_list: D017319:Photosensitizing Agents; D013267:Stilbenes; D013501:Surface-Active Agents; C000617116:tetraphenylethylene; D026082:Singlet Oxygen; D012967:Sodium Dodecyl Sulfate