title: A family-based association study of the HTR1B gene in eating disorders.
abstract: OBJECTIVE
  To explore the association of three polymorphisms of the serotonin receptor 1Dβ gene (HTR1B) in the etiology of eating disorders and their relationship with clinical characteristics.
  
  
  METHODS
  We analyzed the G861C, A-161T, and A1180G polymorphisms of the HTR1B gene through a family-based association test (FBAT) in 245 nuclear families. The sample was stratified into anorexia nervosa (AN) spectrum and bulimia nervosa (BN) spectrum. In addition, we performed a quantitative FBAT analysis of anxiety severity, depression severity, and Yale-Brown-Cornell Eating Disorders Scale (YBC-EDS) in the AN and BN-spectrum groups.
  
  
  RESULTS
  FBAT analysis of the A-161T polymorphism found preferential transmission of allele A-161 in the overall sample. This association was stronger when the sample was stratified by spectrums, showing transmission disequilibrium between the A-161 allele and BN spectrum (z = 2.871, p = 0.004). Quantitative trait analysis showed an association between severity of anxiety symptoms and the C861 allele in AN-spectrum participants (z = 2.871, p = 0.004). We found no associations on analysis of depression severity or preoccupation and ritual scores in AN or BN-spectrum participants.
  
  
  CONCLUSIONS
  Our preliminary findings suggest a role of the HTR1B gene in susceptibility to development of BN subtypes. Furthermore, this gene might have an impact on the severity of anxiety in AN-spectrum patients.
authors: Departamento de Farmacogenética, Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, Ciudad de México, México.
authors: Sandra
authors: S
authors: Hernández
authors: Departamento de Farmacogenética, Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, Ciudad de México, México.
authors: Beatriz
authors: B
authors: Camarena
authors: Clínica de Trastornos Alimentarios, Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, Ciudad de México, México.
authors: Laura
authors: L
authors: González
authors: Clínica de Trastornos Alimentarios, Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, Ciudad de México, México.
authors: Alejandro
authors: A
authors: Caballero
authors: Hospital y Atención Psiquiátrica Continua, Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, Ciudad de México, México.
authors: Griselda
authors: G
authors: Flores
authors: Departamento de Farmacogenética, Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, Ciudad de México, México.
authors: Alejandro
authors: A
authors: Aguilar
mesh_terms: D000293:Adolescent; D000328:Adult; D054458:Amplified Fragment Length Polymorphism Analysis; D000856:Anorexia Nervosa / Q000235:genetics* / Q000503:physiopathology; D001007:Anxiety / Q000150:complications / Q000503:physiopathology; D052018:Bulimia Nervosa / Q000235:genetics* / Q000503:physiopathology; D003863:Depression / Q000150:complications / Q000503:physiopathology; D005190:Family; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies / Q000379:methods*; D060005:Genotyping Techniques; D006801:Humans; D008297:Male; D020641:Polymorphism, Single Nucleotide; D011237:Predictive Value of Tests; D044302:Receptor, Serotonin, 5-HT1B / Q000235:genetics*; D012307:Risk Factors; D012720:Severity of Illness Index; D013732:Test Anxiety Scale; D055815:Young Adult
chemical_list: C470302:HTR1B protein, human; D044302:Receptor, Serotonin, 5-HT1B