title: Assessing the reproducibility of high definition urethral pressure profilometry and its correlation with an air-charged system.
abstract: BACKGROUND
  Recently, a new urodynamic method for the assessment of stress urinary incontinence called high definition urethral pressure profilometry (HD-UPP) has been introduced. This method combines a novel microtip catheter with advanced signal processing to enable spatial data location and the reconstruction of a pressure image inside the urethra. In order to assess the reproducibility of HD-UPP data, we statistically evaluate HD-UPP datasets and compare them to data from a double balloon air-charged system.
  
  
  METHODS
  Both catheters are used on sedated female minipigs. Data from the microtip catheter are processed through a signal reconstruction algorithm, urodynamic features are extracted, and compared to the air-charged system. Reproducibility of HD-UPP data is assessed by statistically evaluating consecutive, intra-individual datasets.
  
  
  RESULTS
  HD-UPP delivers results in agreement with previous comparisons of microtip and air-charged systems. The average deviation of two consecutive, intra-individual pressure images is very low at 7 cm H2O.
  
  
  CONCLUSIONS
  HD-UPP provides physicians with detailed information on the pressure distribution inside the urethra. Through comparison with an air-charged catheter, it is shown that HD-UPP delivers results in agreement with previous studies on the comparison of microtip and air-charged catheters. It provides excellent reproducibility, as the difference between sequentially measured profiles from the same minipig is significantly lower than the one between profiles from different minipigs.
authors: University of Stuttgart, Institute for System Dynamics, Stuttgart, Germany.
authors: Mario
authors: M
authors: Klünder
authors: Department of Urology, University of Tübingen, Tübingen, Germany.
authors: Bastian
authors: B
authors: Amend
authors: University of Stuttgart, Institute for System Dynamics, Stuttgart, Germany.
authors: Oliver
authors: O
authors: Sawodny
authors: Department of Urology, University of Tübingen, Tübingen, Germany.
authors: Arnulf
authors: A
authors: Stenzl
authors: University of Stuttgart, Institute for System Dynamics, Stuttgart, Germany.
authors: Michael
authors: M
authors: Ederer
authors: Department of Urology, University of Tübingen, Tübingen, Germany.
authors: Alexandra
authors: A
authors: Kelp
authors: Department of Urology, Paracelsus Medical University of Salzburg, Salzburg, Austria.
authors: Karl-Dietrich
authors: KD
authors: Sievert
authors: University of Stuttgart, Institute for System Dynamics, Stuttgart, Germany.
authors: Ronny
authors: R
authors: Feuer
mesh_terms: D000818:Animals; D057785:Catheters; D005260:Female; D015203:Reproducibility of Results; D013552:Swine; D014521:Urethra / Q000503:physiopathology*; D014550:Urinary Incontinence, Stress / Q000175:diagnosis* / Q000503:physiopathology; D014563:Urodynamics / Q000502:physiology*
keywords: digital signal processing; urinary catheters; urodynamics