title: Corallocins A-C, Nerve Growth and Brain-Derived Neurotrophic Factor Inducing Metabolites from the Mushroom Hericium coralloides.
abstract: Three new natural products, corallocins A-C (1-3), along with two known compounds were isolated from the mushroom Hericium coralloides. Their benzofuranone and isoindolinone structures were elucidated by spectral methods. All corallocins induced nerve growth factor and/or brain-derived neurotrophic factor expression in human 1321N1 astrocytes. Furthermore, corallocin B showed antiproliferative activity against HUVEC and human cancer cell lines MCF-7 and KB-3-1.
authors: Department Microbial Drugs, Helmholtz Centre for Infection Research GmbH , Inhoffenstraße 7, 38124 Braunschweig, Germany.|German Centre for Infection Research (DZIF), partner site Hannover-Braunschweig , 38124 Braunschweig, Germany.
authors: Kathrin
authors: K
authors: Wittstein
authors: Zoological Institute, Technical University of Braunschweig , Spielmannstraße 7, 38106 Braunschweig, Germany.
authors: Monique
authors: M
authors: Rascher
authors: Department Microbial Drugs, Helmholtz Centre for Infection Research GmbH , Inhoffenstraße 7, 38124 Braunschweig, Germany.|German Centre for Infection Research (DZIF), partner site Hannover-Braunschweig , 38124 Braunschweig, Germany.
authors: Zeljka
authors: Z
authors: Rupcic
authors: Department Microbial Drugs, Helmholtz Centre for Infection Research GmbH , Inhoffenstraße 7, 38124 Braunschweig, Germany.|German Centre for Infection Research (DZIF), partner site Hannover-Braunschweig , 38124 Braunschweig, Germany.
authors: Eduard
authors: E
authors: Löwen
authors: Zoological Institute, Technical University of Braunschweig , Spielmannstraße 7, 38106 Braunschweig, Germany.
authors: Barbara
authors: B
authors: Winter
authors: Zoological Institute, Technical University of Braunschweig , Spielmannstraße 7, 38106 Braunschweig, Germany.
authors: Reinhard W
authors: RW
authors: Köster
authors: Department Microbial Drugs, Helmholtz Centre for Infection Research GmbH , Inhoffenstraße 7, 38124 Braunschweig, Germany.|German Centre for Infection Research (DZIF), partner site Hannover-Braunschweig , 38124 Braunschweig, Germany.
authors: Marc
authors: M
authors: Stadler
mesh_terms: D000363:Agaricales / Q000737:chemistry*; D000818:Animals; D001253:Astrocytes / Q000187:drug effects; D001572:Benzofurans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D019208:Brain-Derived Neurotrophic Factor / Q000819:agonists*; D005858:Germany; D006801:Humans; D015394:Molecular Structure; D009414:Nerve Growth Factors / Q000819:agonists*; D009419:Nerve Tissue Proteins; D019906:Nuclear Magnetic Resonance, Biomolecular; D016716:PC12 Cells; D051381:Rats
chemical_list: D001572:Benzofurans; D019208:Brain-Derived Neurotrophic Factor; D009414:Nerve Growth Factors; D009419:Nerve Tissue Proteins; C000620739:corallocin A; C000620740:corallocin B; C000620741:corallocin C