title: Impact of Donor Source on the Outcome of Live Donor Kidney Transplantation: A Single Center Experience.
abstract: BACKGROUND
  Renal transplantation is the ideal method for management of end-stage renal disease. The use of living donors for renal transplantation was critical for early development in the field and preceded the use of cadaveric donors. Most donors are related genetically to the recipients, like a parent, a child, or a sibling of the recipient, but there are an increasing percentage of cases where donors are genetically unrelated like spouses, friends, or altruistic individuals. Donor shortages constitute the major barrier for kidney transplantation, and much effort has been made to increase the supply of living donors. The impact of donor source on the outcome of renal transplantation is not adequately studied in our country.
  
  
  OBJECTIVE
  The aim of the study was to evaluate the impact of donor source on the outcome of live donor kidney transplantation.
  
  
  METHODS
  From March 1976 to December 2013, the number of patients that underwent living renal transplantation sharing at least one HLA haplotype with their donors was 2,485. We divided these patients into two groups: (1) 2,075 kidney transplant recipients (1,554 or 74.9% male and 521 or 25.1% female) for whom the donors were living related, (2) 410 kidney transplant recipients (297 or 72.4% male and 113 or 27.6% female) for whom the donors were living unrelated. All patients received immunosuppressive therapy, consisting of a calcineurin inhibitor, mycophenolate mofetil, or azathioprine and prednisolone. We compared acute rejection and complication rates, as well as long-term graft and patient survival of both groups. Demographic characteristics were compared using the chi-square test. Graft survival and patient survival were calculated using the Kaplan-Meier method.
  
  
  RESULTS
  The percentages of patients with acute vascular rejection were significantly higher in the unrelated group, while percentages of patients with no rejection were significantly higher in the related group, but there were no significant differences regarding patient and graft survivals between both groups.
  
  
  CONCLUSIONS
  Kidney transplant recipients who received their grafts either from live related donors or live unrelated donors had comparable patient and graft survival outcomes.
authors: Department of Dialysis and Transplantation, The Urology-Nephrology Center, Mansoura University, Mansoura, Egypt.
authors: Yasser Elsayed
authors: YE
authors: Matter
authors: Department of Dialysis and Transplantation, The Urology-Nephrology Center, Mansoura University, Mansoura, Egypt.
authors: Ayman M
authors: AM
authors: Nagib
authors: Department of Nephrology, Zagazig University, Zagazig, Egypt.
authors: Omar E
authors: OE
authors: Lotfy
authors: Department of Nephrology, Zagazig University, Zagazig, Egypt.
authors: Ahmed Maher
authors: AM
authors: Alsayed
authors: Department of Dialysis and Transplantation, The Urology-Nephrology Center, Mansoura University, Mansoura, Egypt.
authors: Ahmed F
authors: AF
authors: Donia
authors: Department of Dialysis and Transplantation, The Urology-Nephrology Center, Mansoura University, Mansoura, Egypt.
authors: Ayman F
authors: AF
authors: Refaie
authors: Department of Dialysis and Transplantation, The Urology-Nephrology Center, Mansoura University, Mansoura, Egypt.
authors: Ahmed I
authors: AI
authors: Akl
authors: Department of Dialysis and Transplantation, The Urology-Nephrology Center, Mansoura University, Mansoura, Egypt.
authors: Mohamed Hamed
authors: MH
authors: Abbas
authors: Department of Dialysis and Transplantation, The Urology-Nephrology Center, Mansoura University, Mansoura, Egypt.
authors: Mohammed M
authors: MM
authors: Abuelmagd
authors: Department of Dialysis and Transplantation, The Urology-Nephrology Center, Mansoura University, Mansoura, Egypt.
authors: Hussein A
authors: HA
authors: Shaeashaa
authors: Department of Urology, The Urology-Nephrology Center, Mansoura University, Mansoura, Egypt.
authors: Ahmed A
authors: AA
authors: Shokeir
keywords: Consanguinity; Kidney Transplantation; Live-Donor