title: Mucosal exfoliation as a selective reaction to etoricoxib.
abstract: OBJECTIVE
  Etoricoxib is a non-steroidal anti-inflammatory drug (NSAID) that inhibits the inducible cyclooxygenase (COX-2) with a good safety profile. We describe the first case of two mucosal adverse events to etoricoxib in the same patient.
  
  
  METHODS
  Our patient developed stomatitis with mucosal exfoliation after etoricoxib assumption. Some months later, after a new etoricoxib intake, she presented with vaginal burning, tongue angioedema and erosions, oral exfoliation and wheals on the hands. A provocation test with diclofenac was negative.
  
  
  CONCLUSIONS
  The peculiarities of our case are the rare clinical manifestation and the selective hypersensitivity to COX-2 inhibitor with tolerance to a non-selective NSAID.
authors: Department of Clinical and Experimental Medicine, School and Division of Allergy and Clinical Immunology, University Hospital "G. Martino", Messina, Italy.
authors: M
authors: M
authors: Patanè
authors: Department of Clinical and Experimental Medicine, School and Division of Allergy and Clinical Immunology, University Hospital "G. Martino", Messina, Italy.
authors: S
authors: S
authors: Isola
authors: Department of Clinical and Experimental Medicine, School and Division of Allergy and Clinical Immunology, University Hospital "G. Martino", Messina, Italy.|Institute of Applied Sciences and Intelligent Systems (ISASI), Messina, Italy.
authors: S
authors: S
authors: Gangemi
authors: Department of Clinical and Experimental Medicine, School and Division of Allergy and Clinical Immunology, University Hospital "G. Martino", Messina, Italy. pminciullo@unime.it.
authors: P L
authors: PL
authors: Minciullo
mesh_terms: D000328:Adult; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D052246:Cyclooxygenase 2 Inhibitors / Q000009:adverse effects; D004342:Drug Hypersensitivity / Q000209:etiology; D000077613:Etoricoxib; D017889:Exfoliation Syndrome / Q000139:chemically induced*; D005260:Female; D006801:Humans; D009092:Mucous Membrane / Q000187:drug effects*; D011725:Pyridines / Q000009:adverse effects*; D013450:Sulfones / Q000009:adverse effects*
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D052246:Cyclooxygenase 2 Inhibitors; D011725:Pyridines; D013450:Sulfones; D000077613:Etoricoxib
keywords: adverse effect; adverse event; coxibs; drugs; non-steroidal anti-inflammatory