title: Investigation and Application of Amphoteric α-Amino Aldehyde: An in Situ Generated Species Based on Heyns Rearrangement.
abstract: In situ generation of the reactive amphoteric α-amino aldehyde with simple α-hydroxy ketones and phenylamine via Heyns rearrangement was proven to be feasible. Metal-free domino reactions based on this reactive intermediate were effectively used to afford important N-heterocycles including polysubstituted pyrroles, indoles, and quinoxalines conveniently. A simple starting material, water as the only byproduct, and diversity of the useful products will make this method greatly attractive for pharmaceutics.
authors: Natural Products Research Center, Chengdu Institution of Biology, Chinese Academy of Science , No. 9 Section 4, Renmin Nan Road, Chengdu 610041, China.
authors: Guangxun
authors: G
authors: Li
authors: Natural Products Research Center, Chengdu Institution of Biology, Chinese Academy of Science , No. 9 Section 4, Renmin Nan Road, Chengdu 610041, China.
authors: Ling
authors: L
authors: Tang
authors: Natural Products Research Center, Chengdu Institution of Biology, Chinese Academy of Science , No. 9 Section 4, Renmin Nan Road, Chengdu 610041, China.
authors: Hongxin
authors: H
authors: Liu
authors: College of Chemical Engineering, Si Chuan University , Chengdu 610041, China.
authors: Yingwei
authors: Y
authors: Wang
authors: College of Chemical Engineering, Si Chuan University , Chengdu 610041, China.
authors: Gang
authors: G
authors: Zhao
authors: Natural Products Research Center, Chengdu Institution of Biology, Chinese Academy of Science , No. 9 Section 4, Renmin Nan Road, Chengdu 610041, China.
authors: Zhuo
authors: Z
authors: Tang