title: A derangement of the brain wound healing process may cause some cases of Alzheimer's disease.
abstract: A derangement of brain wound healing may cause some cases of Alzheimer's disease. Wound healing, a highly complex process, has four stages: hemostasis, inflammation, repair, and remodeling. Hemostasis and the initial phases of inflammation in brain tissue are typical of all vascularized tissue, such as skin. However, distinct differences arise in brain tissue during the later stages of inflammation, repair, and remodeling, and closely parallel the changes of Alzheimer's disease. Our hypothesis -- Alzheimer's disease is brain wound healing gone awry at least in some cases -- could be tested by measuring progression with biomarkers for the four stages of wound healing in humans or appropriate animal models. Autopsy studies might be done. Chronic traumatic encephalopathy might also result from the brain wound healing process.
authors: Fermata Pharma, Inc., 30 West 60th St., New York, NY 10023, USA.
authors: Steven
authors: S
authors: Lehrer
authors: Severn Health Solutions, 621 Holly Ridge Rd., Severna Park, MD 21146, USA.
authors: Peter H
authors: PH
authors: Rheinstein
mesh_terms: D000544:Alzheimer Disease / Q000378:metabolism* / Q000473:pathology*; D000818:Animals; D001241:Aspirin / Q000494:pharmacology; D001921:Brain / Q000187:drug effects / Q000378:metabolism* / Q000473:pathology*; D006801:Humans; D007328:Insulin / Q000494:pharmacology; D014945:Wound Healing / Q000187:drug effects / Q000502:physiology*
chemical_list: D007328:Insulin; D001241:Aspirin