title: Cloning and Characterization of the IgA Fc Receptor from Swine.
abstract: The myeloid-specific IgA Fc receptor (FcαR) is a cell surface molecule on immunocytes that provides a fundamental connection between humoral and cellular immunity. In this study, the full-length cDNA sequence of swine FcαRI (swFcαRI) was isolated and characterized and found to contain a 792-base-pair open reading frame, encoding a 264-amino-acid transmembrane glycoprotein with a predicted molecular mass of 29.4 kDa. The swFcαRI shares high amino acid sequence homology (>50%) with its counterparts from cattle, seal, and horse. Rosetting analysis confirmed that COS-7 cells transfected with an swFcαRI expression plasmid was able to combine with chicken erythrocytes sensitized with porcine IgA, but not IgG.
authors: Henan Provincial Key Laboratory of Animal Immunology, Henan Academy of Agricultural Sciences, Zhengzhou 450002, P.R. China.|College of Basic Medical Science, Zhengzhou University, Zhengzhou 450001, P.R. China.
authors: Yumei
authors: Y
authors: Chen
authors: Henan Provincial Key Laboratory of Animal Immunology, Henan Academy of Agricultural Sciences, Zhengzhou 450002, P.R. China.
authors: Yunchao
authors: Y
authors: Liu
authors: Henan Provincial Key Laboratory of Animal Immunology, Henan Academy of Agricultural Sciences, Zhengzhou 450002, P.R. China.|College of Animal Science and Veterinary Medicine, Henan Agricultural University, Zhengzhou 450002, P.R. China.
authors: Gaiping
authors: G
authors: Zhang
authors: Henan Provincial Key Laboratory of Animal Immunology, Henan Academy of Agricultural Sciences, Zhengzhou 450002, P.R. China.
authors: Hua
authors: H
authors: Feng
authors: Henan Provincial Key Laboratory of Animal Immunology, Henan Academy of Agricultural Sciences, Zhengzhou 450002, P.R. China.
authors: Pengchao
authors: P
authors: Ji
authors: Henan Provincial Key Laboratory of Animal Immunology, Henan Academy of Agricultural Sciences, Zhengzhou 450002, P.R. China.|College of Animal Science and Veterinary Medicine, Henan Agricultural University, Zhengzhou 450002, P.R. China.
authors: Guoqiang
authors: G
authors: Wang
authors: Henan Provincial Key Laboratory of Animal Immunology, Henan Academy of Agricultural Sciences, Zhengzhou 450002, P.R. China.
authors: Chang
authors: C
authors: Liu
authors: Henan Provincial Key Laboratory of Animal Immunology, Henan Academy of Agricultural Sciences, Zhengzhou 450002, P.R. China.|College of Animal Science and Veterinary Medicine, Henan Agricultural University, Zhengzhou 450002, P.R. China.
authors: Yapeng
authors: Y
authors: Song
authors: Henan Provincial Key Laboratory of Animal Immunology, Henan Academy of Agricultural Sciences, Zhengzhou 450002, P.R. China.
authors: Yunfang
authors: Y
authors: Su
authors: Henan Provincial Key Laboratory of Animal Immunology, Henan Academy of Agricultural Sciences, Zhengzhou 450002, P.R. China.
authors: Songlin
authors: S
authors: Qiao
authors: School of Life Sciences, Zhengzhou University, Zhengzhou 450001, P.R. China.
authors: Aiping
authors: A
authors: Wang
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D002417:Cattle; D003001:Cloning, Molecular; D006801:Humans; D007070:Immunoglobulin A / Q000235:genetics / Q000378:metabolism*; D008322:Mammals / Q000145:classification / Q000235:genetics; D008969:Molecular Sequence Data; D016366:Open Reading Frames; D010802:Phylogeny; D011487:Protein Conformation; D000072417:Protein Domains; D011961:Receptors, Fc / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism; D016415:Sequence Alignment; D013552:Swine
chemical_list: D007070:Immunoglobulin A; D011961:Receptors, Fc
keywords: FcαRI; IgA Fc receptor; Swine