title: Solid lipid nanoparticles for antifungal drugs delivery for topical applications.
abstract: Systemic and local infections caused by fungi, in particular those concerning the skin and nails, are increasing. Various drugs are used for mycoses treatment such as amphotericin B, nystatin and ketoconazole, fluconazole, itraconazole and fluconazole, among others. Unfortunately, many of these antifungal agents can cause side effects such as allergic and severe skin reaction. With the aim to reduce these side effects and maximize the antifungal drug activity, various drug-delivery systems have been formulated and been investigated in the last few years. In this context, solid lipid nanoparticles are attracting great attention. The aim of this review is to highlight the role of solid lipid nanoparticles as carriers of antifungal drugs for topical applications.
authors: Department of Pharmacy, Health & Nutritional Sciences, University of Calabria, 87036 Arcavacata di Rende (CS), Italy.
authors: Sonia
authors: S
authors: Trombino
authors: Department of Pharmacy, Health & Nutritional Sciences, University of Calabria, 87036 Arcavacata di Rende (CS), Italy.
authors: Silvia
authors: S
authors: Mellace
authors: Department of Pharmacy, Health & Nutritional Sciences, University of Calabria, 87036 Arcavacata di Rende (CS), Italy.
authors: Roberta
authors: R
authors: Cassano
mesh_terms: D000666:Amphotericin B; D000935:Antifungal Agents / Q000008:administration & dosage*; D016503:Drug Delivery Systems; D015725:Fluconazole; D006801:Humans; D017964:Itraconazole; D008055:Lipids; D053758:Nanoparticles
chemical_list: D000935:Antifungal Agents; D008055:Lipids; D017964:Itraconazole; D000666:Amphotericin B; D015725:Fluconazole
keywords: antifungal drugs; drug delivery systems; solid lipid nanoparticles