title: [Correlation of cytogenetic changes with VEGF and TRacp-5b levels among 60 elderly patients with multiple myeloma].
abstract: OBJECTIVE
  To assess the correlation of cytogenetic changes with serum vascular endothelial growth factor (VEGF) and serum tartrate resistant acid phosphatase (TRacp-5b) levels among elderly patients with multiple myeloma (MM).
  
  
  METHODS
  Chromosomal changes were analyzed with a modified culturing method in the presence of IL-6. Serum levels of VEGF and TRacp-5b were determined with enzyme-linked immunosorbent assays (ELISA).
  
  
  RESULTS
  Among the 60 MM patients, chromosomal abnormalities were found in 27 cases, including 22 with numerical abnormalities and 15 with structural abnormalities. Many patients had both numerical and structural abnormalities. For 33 patients with a normal karyotype, the levels of VEGF and TRacp-5b were 117.35 ± 55.26 pg/mL and 4.15 ± 2.15 U/L, respectively, while for 27 patients with an abnormal karyotype, the levels of VEGF and TRacp-5b were 190.26 ± 85.74 pg/ml and 5.96 ± 2.24 U/L, respectively. The difference between the two groups was significant (P<0.05).
  
  
  CONCLUSIONS
  Compared with MM patients with a normal karyotype, the levels of VEGF and TRacp-5b are higher in those with cytogenetic abnormalities.
authors: Central Laboratory, Changzhou Second Hospital Affiliated to Nanjing Medical University, Changzhou, Jiangsu 213000, China. Email: 15295189493@163.com.
authors: Ling
authors: L
authors: Cen
authors: Yu
authors: Y
authors: Jiang
authors: Xiuwen
authors: X
authors: Zhang
authors: Hongying
authors: H
authors: Chao
authors: Rong
authors: R
authors: Xiao
authors: Wenmin
authors: W
authors: Han
authors: Tao
authors: T
authors: Chen
authors: Xuzhang
authors: X
authors: Lu
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002869:Chromosome Aberrations; D020732:Cytogenetic Analysis; D005260:Female; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D059785:Karyotype; D008297:Male; D009101:Multiple Myeloma / Q000097:blood* / Q000175:diagnosis / Q000235:genetics*; D000071681:Tartrate-Resistant Acid Phosphatase / Q000097:blood*; D042461:Vascular Endothelial Growth Factor A / Q000097:blood*
chemical_list: D042461:Vascular Endothelial Growth Factor A; C000605510:ACP5 protein, human; D000071681:Tartrate-Resistant Acid Phosphatase