title: Quercetin Inhibits Peripheral and Spinal Cord Nociceptive Mechanisms to Reduce Intense Acute Swimming-Induced Muscle Pain in Mice.
abstract: The present study aimed to evaluate the effects of the flavonoid quercetin (3,3´,4´,5,7-pentahydroxyflavone) in a mice model of intense acute swimming-induced muscle pain, which resembles delayed onset muscle soreness. Quercetin intraperitoneal (i.p.) treatment dose-dependently reduced muscle mechanical hyperalgesia. Quercetin inhibited myeloperoxidase (MPO) and N-acetyl-β-D- glucosaminidase (NAG) activities, cytokine production, oxidative stress, cyclooxygenase-2 (COX-2) and gp91phox mRNA expression and muscle injury (creatinine kinase [CK] blood levels and myoblast determination protein [MyoD] mRNA expression) as well as inhibited NFκB activation and induced Nrf2 and HO-1 mRNA expression in the soleus muscle. Beyond inhibiting those peripheral effects, quercetin also inhibited spinal cord cytokine production, oxidative stress and glial cells activation (glial fibrillary acidic protein [GFAP] and ionized calcium-binding adapter molecule 1 [Iba-1] mRNA expression). Concluding, the present data demonstrate that quercetin is a potential molecule for the treatment of muscle pain conditions related to unaccustomed exercise.
authors: Departamento de Ciências Patológicas, Centro de Ciências Biológicas, Universidade Estadual de Londrina, Rodovia Celso Garcia Cid, Km 380, PR445, Cx. Postal 10.011, 86057-970, Londrina, Paraná, Brasil.
authors: Sergio M
authors: SM
authors: Borghi
authors: Departamento de Ciências Patológicas, Centro de Ciências Biológicas, Universidade Estadual de Londrina, Rodovia Celso Garcia Cid, Km 380, PR445, Cx. Postal 10.011, 86057-970, Londrina, Paraná, Brasil.
authors: Felipe A
authors: FA
authors: Pinho-Ribeiro
authors: Departamento de Ciências Patológicas, Centro de Ciências Biológicas, Universidade Estadual de Londrina, Rodovia Celso Garcia Cid, Km 380, PR445, Cx. Postal 10.011, 86057-970, Londrina, Paraná, Brasil.
authors: Victor
authors: V
authors: Fattori
authors: Laboratório de Anatomia Patológica, Centro de Ciências de Saúde, Universidade Estadual de Londrina, Avenida Robert Koch, 60, Hospital Universitário, 86039-440, Londrina, Paraná, Brasil.
authors: Allan J C
authors: AJ
authors: Bussmann
authors: Departamento de Bioquímica e Biotecnologia, Centro de Ciências Exatas, Universidade Estadual de Londrina, Rodovia Celso Garcia Cid, Km 380, PR445, Cx. Postal 10.011, 86057-970, Londrina, Paraná, Brasil.
authors: Josiane A
authors: JA
authors: Vignoli
authors: Departamento de Bioquímica e Biotecnologia, Centro de Ciências Exatas, Universidade Estadual de Londrina, Rodovia Celso Garcia Cid, Km 380, PR445, Cx. Postal 10.011, 86057-970, Londrina, Paraná, Brasil.
authors: Doumit
authors: D
authors: Camilios-Neto
authors: Departamento de Ciências Farmacêuticas, Centro de Ciências de Saúde, Universidade Estadual de Londrina, Avenida Robert Koch, 60, Hospital Universitário, 86039-440, Londrina, Paraná, Brasil.
authors: Rubia
authors: R
authors: Casagrande
authors: Departamento de Ciências Patológicas, Centro de Ciências Biológicas, Universidade Estadual de Londrina, Rodovia Celso Garcia Cid, Km 380, PR445, Cx. Postal 10.011, 86057-970, Londrina, Paraná, Brasil.
authors: Waldiceu A
authors: WA
authors: Verri
mesh_terms: D059787:Acute Pain / Q000209:etiology / Q000503:physiopathology*; D000818:Animals; D051379:Mice; D059225:Nociception / Q000187:drug effects*; D017933:Peripheral Nervous System / Q000503:physiopathology*; D011794:Quercetin / Q000494:pharmacology*; D013116:Spinal Cord / Q000187:drug effects* / Q000503:physiopathology; D013550:Swimming
chemical_list: D011794:Quercetin