title: FeIII-Doped Two-Dimensional C3N4Nanofusiform: A New O2-Evolving and Mitochondria-Targeting Photodynamic Agent for MRI and Enhanced Antitumor Therapy.
abstract: Local hypoxia in tumors, as well as the short lifetime and limited action region of1O2, are undesirable impediments for photodynamic therapy (PDT), leading to a greatly reduced effectiveness. To overcome these adversities, a mitochondria-targeting, H2O2-activatable, and O2-evolving PDT nanoplatform is developed based on FeIII-doped two-dimensional C3N4nanofusiform for highly selective and efficient cancer treatment. The ultrahigh surface area of 2D nanosheets enhances the photosensitizer (PS) loading capacity and the doping of FeIIIleads to peroxidase mimetics with excellent catalytic performance towards H2O2in cancer cells to generate O2. As such tumor hypoxia can be overcome and the PDT efficacy is improved, whilst at the same time endowing the PDT theranostic agent with an effective T1-weighted in vivo magnetic resonance imaging (MRI) ability. Conjugation with a mitochondria-targeting agent could further increase the sensitivity of cancer cells to1O2by enhanced mitochondria dysfunction. In vitro and in vivo anticancer studies demonstrate an outstanding therapeutic effectiveness of the developed PDT agent, leading to almost complete destruction of mouse cervical tumor. This development offers an attractive theranostic agent for in vivo MRI and synergistic photodynamic therapy toward clinical applications.
authors: State Key Lab of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, Jilin, P. R. China.|Graduate School of the Chinese Academy of Sciences, Beijing, 100039, P. R. China.
authors: Zhifang
authors: Z
authors: Ma
authors: Department of Radiology, China-Japan Union Hospital of Jilin University, Changchun, 130022, Jilin, P. R. China.
authors: Mengchao
authors: M
authors: Zhang
authors: State Key Lab of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, Jilin, P. R. China.
authors: Xiaodan
authors: X
authors: Jia
authors: State Key Lab of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, Jilin, P. R. China.
authors: Jing
authors: J
authors: Bai
authors: State Key Lab of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, Jilin, P. R. China.|Graduate School of the Chinese Academy of Sciences, Beijing, 100039, P. R. China.
authors: Yudi
authors: Y
authors: Ruan
authors: State Key Lab of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, Jilin, P. R. China.|Graduate School of the Chinese Academy of Sciences, Beijing, 100039, P. R. China.
authors: Chao
authors: C
authors: Wang
authors: Department of Chemical Engineering, Sichuan University, Chengdu, 610065, Sichuan, P. R. China.
authors: Xuping
authors: X
authors: Sun
authors: State Key Lab of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, Jilin, P. R. China. jiangxiue@ciac.ac.cn.
authors: Xiue
authors: X
authors: Jiang
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D002384:Catalysis; D002470:Cell Survival / Q000187:drug effects; D005260:Female; D006367:HeLa Cells; D006801:Humans; D006861:Hydrogen Peroxide / Q000494:pharmacology; D007501:Iron / Q000737:chemistry*; D008279:Magnetic Resonance Imaging; D053078:Membrane Potential, Mitochondrial / Q000187:drug effects; D008751:Methylene Blue / Q000737:chemistry / Q000494:pharmacology; D051379:Mice; D008928:Mitochondria / Q000187:drug effects / Q000378:metabolism*; D053758:Nanoparticles / Q000737:chemistry*; D010100:Oxygen / Q000032:analysis*; D010778:Photochemotherapy; D017319:Photosensitizing Agents / Q000494:pharmacology*; D013481:Superoxides / Q000737:chemistry; D000068936:Theranostic Nanomedicine
chemical_list: D000970:Antineoplastic Agents; D017319:Photosensitizing Agents; D013481:Superoxides; D006861:Hydrogen Peroxide; D007501:Iron; D010100:Oxygen; D008751:Methylene Blue
keywords: biofunctional materials; cancer therapy; catalyst; drugs; iron; theranostics