title: Antitumor effect of Deoxypodophyllotoxin on human breast cancer xenograft transplanted in BALB/c nude mice model.
abstract: Recently, biologically active compounds isolated from plants used in herbal medicine have been the center of interest. Deoxypodophyllotoxin (DPT), structurally closely related to the lignan podophyllotoxin, was found to be a potent antitumor and antiproliferative agent, in several tumor cells, in vitro. However, DPT has not been used clinically yet because of the lack of in vivo studies. This study is the first report demonstrating the antitumor effect of DPT on MDA-MB-231 human breast cancer xenografts in nude mice. DPT, significantly, inhibited the growth of MDA-MB-231 xenograft in BALB/c nude mice. The T/C value (the value of the relative tumor volume of treatment group compared to the control group) of groups treated with 5, 10, and 20 mg/kg of intravenous DPT-HP-β-CD was 42.87%, 34.04% and 9.63%, respectively, suggesting the positive antitumor activity of DPT. In addition, the antitumor effect of DPT-HP-β-CD (20 mg/kg) in human breast cancer MDA-MB-231 xenograft was more effective than etoposide (VP-16) (20 mg/kg) and docetaxel (20 mg/kg). These findings suggest that this drug is a promising chemotherapy candidate against human breast carcinoma.
authors: Faculty of Life and Natural Sciences, Batna 2 University, Fesdis, Batna 05000, Algeria. Electronic address: mayada_pharm@hotmail.fr.
authors: Meyada
authors: M
authors: Khaled
authors: Department of Medicine, Faculty of Medicine, Batna 2 University, Ezzouhour, Batna 05000, Algeria. Electronic address: gbelaaloui@yahoo.fr.
authors: Ghania
authors: G
authors: Belaaloui
authors: Jiangsu Key Laboratory of Drug Screening, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing 210009, PR China; Jiangsu Center for Pharmacodynamics Research and Evaluation, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing 210009, PR China. Electronic address: beaglejiang@cpu.edu.cn.
authors: Zhen-Zhou
authors: ZZ
authors: Jiang
authors: Medical and Chemical Institute, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing 210009, PR China. Electronic address: cpuzx@foxmail.com.
authors: Xiong
authors: X
authors: Zhu
authors: Jiangsu Key Laboratory of Drug Screening, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing 210009, PR China. Electronic address: lyzhang@cpu.edu.cn.
authors: Lu-Yong
authors: LY
authors: Zhang
mesh_terms: D000073738:2-Hydroxypropyl-beta-cyclodextrin; D061605:Administration, Intravenous; D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage / Q000627:therapeutic use*; D001943:Breast Neoplasms / Q000188:drug therapy*; D045744:Cell Line, Tumor; D000077143:Docetaxel; D004365:Drugs, Chinese Herbal; D005047:Etoposide / Q000008:administration & dosage / Q000737:chemistry / Q000627:therapeutic use; D005260:Female; D006801:Humans; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D011034:Podophyllotoxin / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000737:chemistry / Q000627:therapeutic use; D043823:Taxoids / Q000008:administration & dosage / Q000737:chemistry / Q000627:therapeutic use; D023041:Xenograft Model Antitumor Assays; D047392:beta-Cyclodextrins / Q000008:administration & dosage / Q000737:chemistry / Q000627:therapeutic use
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D004365:Drugs, Chinese Herbal; D043823:Taxoids; D047392:beta-Cyclodextrins; D000077143:Docetaxel; D000073738:2-Hydroxypropyl-beta-cyclodextrin; C014451:deoxypodophyllotoxin; D005047:Etoposide; D011034:Podophyllotoxin
keywords: Breast cancer; DPT-β-CD; Docetaxel; MDA-MB-231; Nude mice; VP-16