title: Clinical study of the impact on ovarian reserve by different hemostasis methods in laparoscopic cystectomy for ovarian endometrioma.
abstract: OBJECTIVE
  To evaluate the impact of different hemostasis methods on ovarian reserve in laparoscopic cystectomy in treatment of ovarian endometrioma for the long-term.
  
  
  METHODS
  A total of 207 patients with ovarian endometrioma, aged from 18 years to 45 years, were randomized into three groups: Group A (69 patients) treated by bipolar electrocoagulation hemostasis in laparoscopic cystectomy for ovarian endometrioma; Group B (69 patients) with ultrasound scalpel hemostasis; and Group C (69 patients) with suture technique hemostasis. The follicle-stimulating hormone (FSH), anti-Mullerian hormone (AMH), antral follicle count (AFC), and peak systolic velocity (PSV) were observed and compared at the 3(rd) day of the 1(st), 3(rd), 6(th), and 12(th) menstrual cycle after surgery.
  
  
  RESULTS
  (1) A total of 13 out of 207 patients failed; four in Group A, five in Group B, and four in Group C. There was no statistically significant difference between groups (p > 0.05). The failure rate was the highest during the 3(rd) month in the follow up (10 cases). (2) FSH: at the 1(st) month, 3(rd) month, 6(th) month, and 12(th) month follow up, FSH was higher in Group A and Group B than in Group C (p < 0.05). (3) AMH: AMH was significantly lower in Group A and Group B than in Group C (p < 0.05) during the same period. (4) AFC: no difference of AFC was observed at the 1(st) month and 3(rd) month (p > 0.05), whereas at the 6(th) month and 12(th) month, AFC in Group C was obviously higher than that in Group A and Group B (p < 0.05). (5) PSV: at the 1(st) month, 3(rd) month, 6(th) month, and 12(th) month follow up, PSV was significantly lower in Group A and in Group B than in Group C (p < 0.05).
  
  
  CONCLUSIONS
  Ultrasonic scalpel or bipolar electrocoagulation hemostasis applied to laparoscopic cystectomy is associated with a significant reduction of ovarian reserve. Electrocoagulation of hemostasis should be used with caution.
authors: Huai'an Maternal and Child Health Care Center, Huai'an City, PR China.
authors: Chun-Hua
authors: CH
authors: Zhang
authors: Huai'an Maternal and Child Health Care Center, Huai'an City, PR China. Electronic address: 18705130528@163.com.
authors: Ling
authors: L
authors: Wu
authors: Huai'an Maternal and Child Health Care Center, Huai'an City, PR China.
authors: Pei-Quan
authors: PQ
authors: Li
mesh_terms: D000293:Adolescent; D000328:Adult; D054304:Anti-Mullerian Hormone / Q000097:blood; D004564:Electrocoagulation; D004715:Endometriosis / Q000503:physiopathology / Q000601:surgery*; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D013509:Gynecologic Surgical Procedures / Q000379:methods*; D006488:Hemostasis, Surgical / Q000379:methods*; D006801:Humans; D010535:Laparoscopy; D008597:Menstrual Cycle / Q000097:blood; D008875:Middle Aged; D010049:Ovarian Diseases / Q000503:physiopathology / Q000601:surgery*; D006080:Ovarian Follicle; D065851:Ovarian Reserve / Q000502:physiology*; D010053:Ovary / Q000503:physiopathology / Q000601:surgery; D011184:Postoperative Period; D013536:Suture Techniques; D013997:Time Factors; D014463:Ultrasonography; D055815:Young Adult
chemical_list: D054304:Anti-Mullerian Hormone; D005640:Follicle Stimulating Hormone
keywords: hemostasis; laparoscopy; ovarian cyst; ovarian endometrioma