title: Light activated liposomes: Functionality and prospects in ocular drug delivery.
abstract: Ocular drug delivery, especially to the retina and choroid, is a major challenge in drug development. Liposome technology may be useful in ophthalmology in enabling new routes of delivery, prolongation of drug action and intracellular drug delivery, but drug release from the liposomes should be controlled. For that purpose, light activation may be an approach to release drug at specified time and site in the eye. Technical advances have been made in the field of light activated drug release, particularly indocyanine green loaded liposomes are a promising approach with safe materials and effective light triggered release of small and large molecules. This review discusses the liposomal drug delivery with light activated systems in the context of ophthalmic drug delivery challenges.
authors: Centre for Drug Research, Division of Pharmaceutical Biosciences, University of Helsinki, Viikinkaari 5 E, 00790 Helsinki, Finland.
authors: Tatu
authors: T
authors: Lajunen
authors: Centre for Drug Research, Division of Pharmaceutical Biosciences, University of Helsinki, Viikinkaari 5 E, 00790 Helsinki, Finland.
authors: Riikka
authors: R
authors: Nurmi
authors: Centre for Drug Research, Division of Pharmaceutical Biosciences, University of Helsinki, Viikinkaari 5 E, 00790 Helsinki, Finland; Department of Pharmaceutics, University of Utrecht, Utrecht, The Netherlands.
authors: Leena
authors: L
authors: Kontturi
authors: Department of Chemistry, Aalto University, Espoo, Finland.
authors: Lauri
authors: L
authors: Viitala
authors: Centre for Drug Research, Division of Pharmaceutical Biosciences, University of Helsinki, Viikinkaari 5 E, 00790 Helsinki, Finland; Department of Pharmaceutical Sciences, University of Padova, Padova, Italy.
authors: Marjo
authors: M
authors: Yliperttula
authors: Department of Chemistry, Aalto University, Espoo, Finland.
authors: Lasse
authors: L
authors: Murtomäki
authors: Centre for Drug Research, Division of Pharmaceutical Biosciences, University of Helsinki, Viikinkaari 5 E, 00790 Helsinki, Finland; School of Pharmacy, University of Eastern Finland, 70211 Kuopio, Finland. Electronic address: arto.urtti@helsinki.fi.
authors: Arto
authors: A
authors: Urtti
mesh_terms: D060433:Administration, Ophthalmic; D000818:Animals; D016503:Drug Delivery Systems; D005123:Eye / Q000378:metabolism; D006801:Humans; D008027:Light; D008081:Liposomes / Q000528:radiation effects*
chemical_list: D008081:Liposomes
keywords: Drug release; Light activation; Liposome; Ocular drug delivery; Posterior segment; Retina; Thermosensitive