title: Evidence from a large-scale meta-analysis indicates eczema reduces the incidence of glioma.
abstract: We investigated the relationship between eczema and the risk of primary glioma. Relevant studies were selected through electronic searches of PubMed and EMBASE. A meta-analysis of 12 case-control studies and one cohort study was performed. A fixed effect model was applied to analyze 13 studies consisting of 10,897 glioma cases and 56,081 controls. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated to assess the strength of the associations. The data demonstrate that eczema significantly reduces the risk of glioma (OR = 0.69, 95% CI = 0.61-0.78, P < 0.001). Additional studies with larger patient cohorts are required to validate our findings.
authors: Academy of Nursing, Zhejiang Chinese Medical University, Hangzhou 310053, China.|Blood Purification Center, Ningbo Medical Center, Lihuili Hospital, Ningbo University, Ningbo 315041, China.
authors: Guannan
authors: G
authors: Wang
authors: Department of Dermatology, Affiliated Hospital of Medical College, Ningbo University, Ningbo 315020, China.|Department of Dermatology, Ningbo First Hospital, Ningbo University, Ningbo 315010, China.
authors: Suling
authors: S
authors: Xu
authors: Department of Respiratory Medicine, Ningbo First Hospital, Ningbo University, Ningbo 315010, China.
authors: Chao
authors: C
authors: Cao
authors: Blood Purification Center, Ningbo Medical Center, Lihuili Hospital, Ningbo University, Ningbo 315041, China.
authors: Jing
authors: J
authors: Dong
authors: Department of Nephrology, Ningbo Medical Center, Lihuili Eastern Hospital, Ningbo 315040, China.
authors: Yudong
authors: Y
authors: Chu
authors: Academy of Nursing, Zhejiang Chinese Medical University, Hangzhou 310053, China.
authors: Guijuan
authors: G
authors: He
authors: Department of Critical Care Medicine, Ningbo Medical Center, Lihuili Eastern Hospital, Ningbo 315040, China.
authors: Zhiwei
authors: Z
authors: Xu
mesh_terms: D001932:Brain Neoplasms / Q000150:complications* / Q000517:prevention & control*; D016022:Case-Control Studies; D015331:Cohort Studies; D004485:Eczema / Q000150:complications* / Q000503:physiopathology*; D005910:Glioma / Q000150:complications* / Q000517:prevention & control*; D006801:Humans; D016017:Odds Ratio; D012307:Risk Factors
keywords: eczema; glioma; meta-analysis