title: Functional Capacity, Respiratory Muscle Strength, and Oxygen Consumption Predict Mortality in Patients with Cirrhosis.
abstract: Introduction. Liver diseases influence musculoskeletal functions and may negatively affect the exercise capacity of patients with cirrhosis. Aim. To test the relationship between the six-minute walk test (6MWT), maximal inspiratory pressure (MIP), and exercise capacity (VO2peak) measures and the survival rate of patients with cirrhosis. Methods. This prospective cohort study consisted of 86 patients diagnosed with cirrhosis with the following aetiology: hepatitis C virus (HCV), hepatitis B virus (HBV), and/or alcoholic cirrhosis (AC). All patients were followed up for three years and submitted to the 6MWT, pressure measurements with a compound gauge, and an exercise test (VO2peak). Results. The survival analysis showed that the individuals who covered a distance shorter than 410 m during the 6MWT had a survival rate of 55% compared with a rate of 97% for the individuals who walked more than 410 m (p = 0.0001). Individuals with MIPs below -70 cmH2O had a survival rate of 62% compared with a rate of 93% for those with MIPs above -70 cmH2O (p = 0.0001). The patients with values below 17 mL/kg had a survival rate of 55% compared with a rate of 94% for those with values above 17 mL/kg (p = 0.0001). Conclusion. The 6MWT distance, MIP, and oxygen consumption are predictors of mortality in patients with cirrhosis.
authors: Graduate Program in Hepatology, Federal University of Health Sciences of Porto Alegre, 90050-170 Porto Alegre, RS, Brazil.
authors: José Leonardo
authors: 0000-0003-1837-5110
authors: JL
authors: Faustini Pereira
authors: Graduate Program in Hepatology, Federal University of Health Sciences of Porto Alegre, 90050-170 Porto Alegre, RS, Brazil.
authors: Lucas Homercher
authors: 0000-0002-4333-1403
authors: LH
authors: Galant
authors: Graduate Program in Hepatology, Federal University of Health Sciences of Porto Alegre, 90050-170 Porto Alegre, RS, Brazil.
authors: Danusa
authors: 0000-0001-6787-4915
authors: D
authors: Rossi
authors: Graduate Program in Rehabilitation Sciences, Federal University of Health Sciences of Porto Alegre, 90050-170 Porto Alegre, RS, Brazil.
authors: Luis Henrique
authors: LH
authors: Telles da Rosa
authors: Federal University of Health Sciences of Porto Alegre, 90050-170 Porto Alegre, RS, Brazil.
authors: Eduardo
authors: E
authors: Garcia
authors: Graduate Program in Hepatology, Federal University of Health Sciences of Porto Alegre, 90050-170 Porto Alegre, RS, Brazil.
authors: Ajácio Bandeira
authors: 0000-0001-8411-5654
authors: AB
authors: de Mello Brandão
authors: Graduate Program in Hepatology, Federal University of Health Sciences of Porto Alegre, 90050-170 Porto Alegre, RS, Brazil.
authors: Cláudio Augusto
authors: CA
authors: Marroni
mesh_terms: D000368:Aged; D005260:Female; D005500:Follow-Up Studies; D006509:Hepatitis B / Q000150:complications; D006526:Hepatitis C / Q000150:complications; D006801:Humans; D008103:Liver Cirrhosis / Q000401:mortality* / Q000503:physiopathology* / Q000821:virology; D008104:Liver Cirrhosis, Alcoholic / Q000401:mortality / Q000503:physiopathology; D008297:Male; D000072277:Maximal Respiratory Pressures; D008875:Middle Aged; D010101:Oxygen Consumption / Q000502:physiology*; D011446:Prospective Studies; D012132:Respiratory Muscles / Q000503:physiopathology*; D015996:Survival Rate; D000070857:Walk Test / Q000379:methods; D016138:Walking / Q000502:physiology*