title: Paramyxovirus RNA synthesis, mRNA editing, and genome hexamer phase: A review.
abstract: The recent flurry of high resolution structures of Negative Strand RNA Virus RNA-dependent RNA polymerases has rekindled interest in the manner in which these polymerases, and in particular those of the nonsegmented viruses, recognize the RNA sequences that control mRNA synthesis and genome replication. In the light of these polymerase structures, we re-examine some unusual aspects of the Paramyxoviridae, namely bipartite replication promoters and mRNA editing, and the manner in which these properties are governed by genome hexamer phase.
authors: Department of Microbiology and Molecular Medicine, University of Geneva School of Medicine, Geneva, Switzerland. Electronic address: Daniel.Kolakofsky@unige.ch.
authors: Daniel
authors: D
authors: Kolakofsky
mesh_terms: D020413:3' Untranslated Regions; D000818:Animals; D015967:Gene Expression Regulation, Viral; D016679:Genome, Viral; D006801:Humans; D010252:Paramyxoviridae / Q000502:physiology*; D011401:Promoter Regions, Genetic; D017393:RNA Editing; D012333:RNA, Messenger; D012367:RNA, Viral / Q000096:biosynthesis*; D014158:Transcription, Genetic; D014764:Viral Proteins / Q000235:genetics
chemical_list: D020413:3' Untranslated Regions; D012333:RNA, Messenger; D012367:RNA, Viral; D014764:Viral Proteins
keywords: Bipartite replication promoters; Genome hexamer phase; MRNA editing; Paramyxoviridae family