title: High CLEC-2 expression associates with unfavorable postoperative prognosis of patients with clear cell renal cell carcinoma.
abstract: We enrolled a total of 277 patients who received nephrectomy due to clear cell renal cell carcinoma (ccRCC) in Zhongshan Hospital from Jan 2005 to Jun 2007. Immunohistochemistry was performed to evaluate the impact of CLEC-2 positive cell infiltration on the overall survival (OS) and recurrence-free survival (RFS) of patients with ccRCC. Kaplan-Meier analysis showed that high CLEC-2 positive cell infiltration in tumor tissue indicated poorer OS and RFS (OS, p < 0.001; RFS, p = 0.002). High CLEC-2 positive cell infiltration is also an independent risk factor for OS and RFS in multivariate analyses (OS, p = 0.004; RFS, p = 0.009). CLEC-2 positive cell infiltration could also stratify ccRCC patients' survival with University of California Integrated Staging System (UISS) stratum in the mediate-risk and high-risk groups. We constructed two nomograms incorporating parameters derived from multivariate analyses to predict patients' OS and RFS (OS, c-index 0.813; RFS, c-index 0.716). In conclusion, high CLEC-2 positive cell infiltration in ccRCC is an independent adverse prognostic factor for patients, and established nomograms based on this information could help predict ccRCC patients' OS and RFS.
authors: Department of Urology, Zhongshan Hospital, Fudan University, Shanghai 200032, China.
authors: Ying
authors: Y
authors: Xiong
authors: Department of Urology, Zhongshan Hospital, Fudan University, Shanghai 200032, China.
authors: Li
authors: L
authors: Liu
authors: Department of Urology, Zhongshan Hospital, Fudan University, Shanghai 200032, China.
authors: Yu
authors: Y
authors: Xia
authors: Department of Urology, Zhongshan Hospital, Fudan University, Shanghai 200032, China.
authors: Jiajun
authors: J
authors: Wang
authors: Department of Urology, Zhongshan Hospital, Fudan University, Shanghai 200032, China.
authors: Wei
authors: W
authors: Xi
authors: Department of Urology, Zhongshan Hospital, Fudan University, Shanghai 200032, China.
authors: Qi
authors: Q
authors: Bai
authors: Department of Urology, Zhongshan Hospital, Fudan University, Shanghai 200032, China.
authors: Yang
authors: Y
authors: Qu
authors: Department of Urology, Zhongshan Hospital, Fudan University, Shanghai 200032, China.
authors: Qilai
authors: Q
authors: Long
authors: Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Fudan University, Shanghai 200032, China.
authors: Jiejie
authors: J
authors: Xu
authors: Department of Urology, Zhongshan Hospital, Fudan University, Shanghai 200032, China.
authors: Jianming
authors: J
authors: Guo
mesh_terms: D002292:Carcinoma, Renal Cell / Q000175:diagnosis / Q000378:metabolism* / Q000601:surgery; D018572:Disease-Free Survival; D020869:Gene Expression Profiling; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D007150:Immunohistochemistry; D053208:Kaplan-Meier Estimate; D007680:Kidney Neoplasms / Q000378:metabolism* / Q000473:pathology / Q000601:surgery; D037181:Lectins, C-Type / Q000235:genetics / Q000378:metabolism*; D008562:Membrane Glycoproteins / Q000235:genetics / Q000378:metabolism*; D015999:Multivariate Analysis; D009362:Neoplasm Metastasis; D009367:Neoplasm Staging; D011184:Postoperative Period; D011379:Prognosis; D016016:Proportional Hazards Models; D012307:Risk Factors; D046888:Tissue Array Analysis; D016896:Treatment Outcome
chemical_list: C104778:CLEC2B protein, human; D037181:Lectins, C-Type; D008562:Membrane Glycoproteins
keywords: c-type lectin-like receptor 2; clear cell renal cell carcinoma; overall survival; prognostic factor; recurrence-free survival