title: Evaluation of results obtained with corifollitropin alfa after poor ovarian response in previous cycle using recombinant follicular stimulating hormone in the long-term protocol.
abstract: This study evaluated the use of Corifollitropin alfa in patients with previous poor response to recombinant follicle stimulating hormone in long-term protocols using gonadotropin-releasing hormone.
  
  
  
  Twenty-seven poor responders to previous treatment with the long term protocol using the recombinant follicle stimulating hormone (Group 1) were selected and then submitted to a second attempt using the same long term protocol with Corifollitropin alfa instead of the recombinant follicle stimulating hormone (Group 2).Ovarian down-regulation was achieved using subcutaneous administration of Leuprolide Acetate. Ovarian stimulation was performed with recombinant follicle stimulating hormone until the administration of human chorionic gonadotropin, followed by follicular aspiration (Group 1). Group 2 was submitted to this same protocol using Corifollitropin alfa instead of recombinant follicle stimulating hormone.
  
  
  
  There were significant differences in the number of aspirated oocytes, percentage of mature oocytes, amount of injected oocytes and transferred embryos - with all of these parameters being increased in the Corifollitropin alfa group. In addition, the rates of pregnancy and ongoing pregnancy were also significantly higher in the Corifollitropin alfa group.
  
  
  
  The present study demonstrated that the use of Corifollitropin alfa in the long-term protocol could be a highly effective alternative for patients with poor ovarian response, who were unsuccessful in a previous treatment with In Vitro Fertilization - Intracytoplasmic Sperm Injection.
authors: Clínica Fértilis de Reprodução Assistida, Sorocaba, SP, Brazil.
authors: Lister L
authors: LL
authors: Salgueiro
authors: Clínica Fértilis de Reprodução Assistida, Sorocaba, SP, Brazil.
authors: Juliana R
authors: JR
authors: Rolim
authors: Clínica Fértilis de Reprodução Assistida, Sorocaba, SP, Brazil.
authors: Bernardo R L
authors: BR
authors: Moura
authors: Clínica Fértilis de Reprodução Assistida, Sorocaba, SP, Brazil.
authors: Suelen P P
authors: SP
authors: Machado
authors: Clínica Fértilis de Reprodução Assistida, Sorocaba, SP, Brazil.
authors: Carolina
authors: C
authors: Haddad
mesh_terms: D000328:Adult; D005260:Female; D005307:Fertilization in Vitro / Q000379:methods* / Q000706:statistics & numerical data*; D005640:Follicle Stimulating Hormone / Q000627:therapeutic use; D043373:Follicle Stimulating Hormone, Human / Q000627:therapeutic use*; D006801:Humans; D011247:Pregnancy; D011994:Recombinant Proteins / Q000627:therapeutic use; D012189:Retrospective Studies
chemical_list: D043373:Follicle Stimulating Hormone, Human; D011994:Recombinant Proteins; C437186:follicle stimulating hormone, human, with HCG C-terminal peptide; D005640:Follicle Stimulating Hormone
keywords: Corifollitropin alfa; In vitro fertilization; Poor responders