title: Glioma in Patients with Autosomal-Dominant Polycystic Kidney Disease.
abstract: BACKGROUND
  Autosomal-dominant polycystic kidney disease (ADPKD) is an inherited systemic condition with a predominant feature of cyst formation in both kidneys. An association with intracranial glioma has not been described previously in ADPKD.
  
  
  METHODS
  We report 2 cases of glioma in patients with ADPKD. One patient had a cystic lesion with contrast enhancement in the right temporal lobe as revealed by magnetic resonance imaging and an aneurysm in left sylvian fissure confirmed by computed tomography angiography. Subsequent histopathologic analysis of the resected enhancing lesion confirmed the diagnosis of glioblastoma (World Health Organization grade IV). The second patient was found to harbor a solid lesion in the right parietal lobe. This lesion also proved to be an astrocytoma (World Health Organization grade II).
  
  
  CONCLUSIONS
  These 2 independent cases of glioma suggest an unusual clinical manifestation of ADPKD. The potential association between ADPKD and glioma pathogenesis should be further explored.
authors: Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China; China National Clinical Research Center for Neurological Diseases, Beijing, China; Neuro-Oncology Branch, National Cancer Institute, Bethesda, Maryland, USA.
authors: Shuyu
authors: S
authors: Hao
authors: Beijing Neurosurgical Institute, Capital Medical University, Beijing, China.
authors: Jie
authors: J
authors: Feng
authors: Neuro-Oncology Branch, National Cancer Institute, Bethesda, Maryland, USA.
authors: Deric M
authors: DM
authors: Park
authors: Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China; China National Clinical Research Center for Neurological Diseases, Beijing, China. Electronic address: zhixian_g@163.com.
authors: Zhixian
authors: Z
authors: Gao
mesh_terms: D000328:Adult; D005910:Glioma / Q000150:complications* / Q000000981:diagnostic imaging / Q000601:surgery*; D006801:Humans; D002532:Intracranial Aneurysm / Q000150:complications* / Q000000981:diagnostic imaging / Q000601:surgery*; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D019635:Neurosurgical Procedures / Q000379:methods*; D016891:Polycystic Kidney, Autosomal Dominant / Q000150:complications* / Q000000981:diagnostic imaging / Q000601:surgery*; D015898:Tomography Scanners, X-Ray Computed
keywords: Autosomal-dominant polycystic kidney disease; Glioma; Treatment