title: CPAP for Prevention of Cardiovascular Events in Obstructive Sleep Apnea.
abstract: Obstructive sleep apnea is associated with an increased risk of cardiovascular events; whether treatment with continuous positive airway pressure (CPAP) prevents major cardiovascular events is uncertain.
  
  
  
  After a 1-week run-in period during which the participants used sham CPAP, we randomly assigned 2717 eligible adults between 45 and 75 years of age who had moderate-to-severe obstructive sleep apnea and coronary or cerebrovascular disease to receive CPAP treatment plus usual care (CPAP group) or usual care alone (usual-care group). The primary composite end point was death from cardiovascular causes, myocardial infarction, stroke, or hospitalization for unstable angina, heart failure, or transient ischemic attack. Secondary end points included other cardiovascular outcomes, health-related quality of life, snoring symptoms, daytime sleepiness, and mood.
  
  
  
  Most of the participants were men who had moderate-to-severe obstructive sleep apnea and minimal sleepiness. In the CPAP group, the mean duration of adherence to CPAP therapy was 3.3 hours per night, and the mean apnea-hypopnea index (the number of apnea or hypopnea events per hour of recording) decreased from 29.0 events per hour at baseline to 3.7 events per hour during follow-up. After a mean follow-up of 3.7 years, a primary end-point event had occurred in 229 participants in the CPAP group (17.0%) and in 207 participants in the usual-care group (15.4%) (hazard ratio with CPAP, 1.10; 95% confidence interval, 0.91 to 1.32; P=0.34). No significant effect on any individual or other composite cardiovascular end point was observed. CPAP significantly reduced snoring and daytime sleepiness and improved health-related quality of life and mood.
  
  
  
  Therapy with CPAP plus usual care, as compared with usual care alone, did not prevent cardiovascular events in patients with moderate-to-severe obstructive sleep apnea and established cardiovascular disease. (Funded by the National Health and Medical Research Council of Australia and others; SAVE ClinicalTrials.gov number, NCT00738179 ; Australian New Zealand Clinical Trials Registry number, ACTRN12608000409370 .).
authors: From the Adelaide Institute for Sleep Health (R.D.M., N.A.A.) and the School of Medicine, Faculty of Medicine, Nursing, and Health Sciences (R.D.M., N.A.A., E.H., B.N., C.S.A.), Flinders University, and Sleep Health Service, Respiratory and Sleep Services, Southern Adelaide Local Health Network (R.D.M., N.A.A., S.M.), Adelaide, SA, George Institute for Global Health (E.H., L.B., Q.L., H.A., B.N., C.S.A.), Sydney Medical School (E.H., L.B., Q.L., H.A., B.N., C.S.A.), and Woolcock Institute of Medical Research (R.R.G.), University of Sydney, and the Departments of Respiratory and Sleep Medicine (R.R.G.) and Neurology (C.S.A.), Royal Prince Alfred Hospital, Sydney Health Partners, Sydney, and the Western Australian Sleep Disorders Research Institute, Sir Charles Gairdner Hospital, Perth, WA (N.M., S.M.) - all in Australia; the First Affiliated Hospital of Guangzhou Medical University, State Key Laboratory of Respiratory Disease (Y.L., N.Z.), and Guangdong General Hospital and Guangdong Academy of Medical Sciences (Q.O.), Guangzhou, the First Affiliated Hospital of Nanjing Medical University, Nanjing (X.Z.), the Second Affiliated Hospital of Soochow University, Suzhou (R.C.), the Department of Cardiology, Fuwai Hospital (Z.L.), and George Institute for Global Health China (C.S.A.), Peking University Health Sciences Center, Beijing, the Department of Neurology, Xuzhou Central Hospital, Xuzhou (G.C.), Hejian Municipal People's Hospital, Hejian (B.D.), and Shanghai Institute of Hypertension, Ruijin Hospital, Shanghai Jiaotong University, Shanghai (J.W.) - all in China; University Hospital of Guadalajara, Guadalajara (O.M.), the Respiratory Department, Institut de Recerca Biomèdica de Lleida, Lleida (F.B.), and Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES), Madrid (F.B.) - all in Spain; Instituto do Coracao (Incor) and Hospital Universitario (L.F.D., G.L.-F.) and the Hypertension Unit, Renal Division, University of São Paulo Medical Sc
authors: R Doug
authors: RD
authors: McEvoy
authors: From the Adelaide Institute for Sleep Health (R.D.M., N.A.A.) and the School of Medicine, Faculty of Medicine, Nursing, and Health Sciences (R.D.M., N.A.A., E.H., B.N., C.S.A.), Flinders University, and Sleep Health Service, Respiratory and Sleep Services, Southern Adelaide Local Health Network (R.D.M., N.A.A., S.M.), Adelaide, SA, George Institute for Global Health (E.H., L.B., Q.L., H.A., B.N., C.S.A.), Sydney Medical School (E.H., L.B., Q.L., H.A., B.N., C.S.A.), and Woolcock Institute of Medical Research (R.R.G.), University of Sydney, and the Departments of Respiratory and Sleep Medicine (R.R.G.) and Neurology (C.S.A.), Royal Prince Alfred Hospital, Sydney Health Partners, Sydney, and the Western Australian Sleep Disorders Research Institute, Sir Charles Gairdner Hospital, Perth, WA (N.M., S.M.) - all in Australia; the First Affiliated Hospital of Guangzhou Medical University, State Key Laboratory of Respiratory Disease (Y.L., N.Z.), and Guangdong General Hospital and Guangdong Academy of Medical Sciences (Q.O.), Guangzhou, the First Affiliated Hospital of Nanjing Medical University, Nanjing (X.Z.), the Second Affiliated Hospital of Soochow University, Suzhou (R.C.), the Department of Cardiology, Fuwai Hospital (Z.L.), and George Institute for Global Health China (C.S.A.), Peking University Health Sciences Center, Beijing, the Department of Neurology, Xuzhou Central Hospital, Xuzhou (G.C.), Hejian Municipal People's Hospital, Hejian (B.D.), and Shanghai Institute of Hypertension, Ruijin Hospital, Shanghai Jiaotong University, Shanghai (J.W.) - all in China; University Hospital of Guadalajara, Guadalajara (O.M.), the Respiratory Department, Institut de Recerca Biomèdica de Lleida, Lleida (F.B.), and Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES), Madrid (F.B.) - all in Spain; Instituto do Coracao (Incor) and Hospital Universitario (L.F.D., G.L.-F.) and the Hypertension Unit, Renal Division, University of São Paulo Medical Sc
authors: Nick A
authors: NA
authors: Antic
authors: From the Adelaide Institute for Sleep Health (R.D.M., N.A.A.) and the School of Medicine, Faculty of Medicine, Nursing, and Health Sciences (R.D.M., N.A.A., E.H., B.N., C.S.A.), Flinders University, and Sleep Health Service, Respiratory and Sleep Services, Southern Adelaide Local Health Network (R.D.M., N.A.A., S.M.), Adelaide, SA, George Institute for Global Health (E.H., L.B., Q.L., H.A., B.N., C.S.A.), Sydney Medical School (E.H., L.B., Q.L., H.A., B.N., C.S.A.), and Woolcock Institute of Medical Research (R.R.G.), University of Sydney, and the Departments of Respiratory and Sleep Medicine (R.R.G.) and Neurology (C.S.A.), Royal Prince Alfred Hospital, Sydney Health Partners, Sydney, and the Western Australian Sleep Disorders Research Institute, Sir Charles Gairdner Hospital, Perth, WA (N.M., S.M.) - all in Australia; the First Affiliated Hospital of Guangzhou Medical University, State Key Laboratory of Respiratory Disease (Y.L., N.Z.), and Guangdong General Hospital and Guangdong Academy of Medical Sciences (Q.O.), Guangzhou, the First Affiliated Hospital of Nanjing Medical University, Nanjing (X.Z.), the Second Affiliated Hospital of Soochow University, Suzhou (R.C.), the Department of Cardiology, Fuwai Hospital (Z.L.), and George Institute for Global Health China (C.S.A.), Peking University Health Sciences Center, Beijing, the Department of Neurology, Xuzhou Central Hospital, Xuzhou (G.C.), Hejian Municipal People's Hospital, Hejian (B.D.), and Shanghai Institute of Hypertension, Ruijin Hospital, Shanghai Jiaotong University, Shanghai (J.W.) - all in China; University Hospital of Guadalajara, Guadalajara (O.M.), the Respiratory Department, Institut de Recerca Biomèdica de Lleida, Lleida (F.B.), and Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES), Madrid (F.B.) - all in Spain; Instituto do Coracao (Incor) and Hospital Universitario (L.F.D., G.L.-F.) and the Hypertension Unit, Renal Division, University of São Paulo Medical Sc
authors: Emma
authors: E
authors: Heeley
authors: From the Adelaide Institute for Sleep Health (R.D.M., N.A.A.) and the School of Medicine, Faculty of Medicine, Nursing, and Health Sciences (R.D.M., N.A.A., E.H., B.N., C.S.A.), Flinders University, and Sleep Health Service, Respiratory and Sleep Services, Southern Adelaide Local Health Network (R.D.M., N.A.A., S.M.), Adelaide, SA, George Institute for Global Health (E.H., L.B., Q.L., H.A., B.N., C.S.A.), Sydney Medical School (E.H., L.B., Q.L., H.A., B.N., C.S.A.), and Woolcock Institute of Medical Research (R.R.G.), University of Sydney, and the Departments of Respiratory and Sleep Medicine (R.R.G.) and Neurology (C.S.A.), Royal Prince Alfred Hospital, Sydney Health Partners, Sydney, and the Western Australian Sleep Disorders Research Institute, Sir Charles Gairdner Hospital, Perth, WA (N.M., S.M.) - all in Australia; the First Affiliated Hospital of Guangzhou Medical University, State Key Laboratory of Respiratory Disease (Y.L., N.Z.), and Guangdong General Hospital and Guangdong Academy of Medical Sciences (Q.O.), Guangzhou, the First Affiliated Hospital of Nanjing Medical University, Nanjing (X.Z.), the Second Affiliated Hospital of Soochow University, Suzhou (R.C.), the Department of Cardiology, Fuwai Hospital (Z.L.), and George Institute for Global Health China (C.S.A.), Peking University Health Sciences Center, Beijing, the Department of Neurology, Xuzhou Central Hospital, Xuzhou (G.C.), Hejian Municipal People's Hospital, Hejian (B.D.), and Shanghai Institute of Hypertension, Ruijin Hospital, Shanghai Jiaotong University, Shanghai (J.W.) - all in China; University Hospital of Guadalajara, Guadalajara (O.M.), the Respiratory Department, Institut de Recerca Biomèdica de Lleida, Lleida (F.B.), and Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES), Madrid (F.B.) - all in Spain; Instituto do Coracao (Incor) and Hospital Universitario (L.F.D., G.L.-F.) and the Hypertension Unit, Renal Division, University of São Paulo Medical Sc
authors: Yuanming
authors: Y
authors: Luo
authors: From the Adelaide Institute for Sleep Health (R.D.M., N.A.A.) and the School of Medicine, Faculty of Medicine, Nursing, and Health Sciences (R.D.M., N.A.A., E.H., B.N., C.S.A.), Flinders University, and Sleep Health Service, Respiratory and Sleep Services, Southern Adelaide Local Health Network (R.D.M., N.A.A., S.M.), Adelaide, SA, George Institute for Global Health (E.H., L.B., Q.L., H.A., B.N., C.S.A.), Sydney Medical School (E.H., L.B., Q.L., H.A., B.N., C.S.A.), and Woolcock Institute of Medical Research (R.R.G.), University of Sydney, and the Departments of Respiratory and Sleep Medicine (R.R.G.) and Neurology (C.S.A.), Royal Prince Alfred Hospital, Sydney Health Partners, Sydney, and the Western Australian Sleep Disorders Research Institute, Sir Charles Gairdner Hospital, Perth, WA (N.M., S.M.) - all in Australia; the First Affiliated Hospital of Guangzhou Medical University, State Key Laboratory of Respiratory Disease (Y.L., N.Z.), and Guangdong General Hospital and Guangdong Academy of Medical Sciences (Q.O.), Guangzhou, the First Affiliated Hospital of Nanjing Medical University, Nanjing (X.Z.), the Second Affiliated Hospital of Soochow University, Suzhou (R.C.), the Department of Cardiology, Fuwai Hospital (Z.L.), and George Institute for Global Health China (C.S.A.), Peking University Health Sciences Center, Beijing, the Department of Neurology, Xuzhou Central Hospital, Xuzhou (G.C.), Hejian Municipal People's Hospital, Hejian (B.D.), and Shanghai Institute of Hypertension, Ruijin Hospital, Shanghai Jiaotong University, Shanghai (J.W.) - all in China; University Hospital of Guadalajara, Guadalajara (O.M.), the Respiratory Department, Institut de Recerca Biomèdica de Lleida, Lleida (F.B.), and Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES), Madrid (F.B.) - all in Spain; Instituto do Coracao (Incor) and Hospital Universitario (L.F.D., G.L.-F.) and the Hypertension Unit, Renal Division, University of São Paulo Medical Sc
authors: Qiong
authors: Q
authors: Ou
authors: From the Adelaide Institute for Sleep Health (R.D.M., N.A.A.) and the School of Medicine, Faculty of Medicine, Nursing, and Health Sciences (R.D.M., N.A.A., E.H., B.N., C.S.A.), Flinders University, and Sleep Health Service, Respiratory and Sleep Services, Southern Adelaide Local Health Network (R.D.M., N.A.A., S.M.), Adelaide, SA, George Institute for Global Health (E.H., L.B., Q.L., H.A., B.N., C.S.A.), Sydney Medical School (E.H., L.B., Q.L., H.A., B.N., C.S.A.), and Woolcock Institute of Medical Research (R.R.G.), University of Sydney, and the Departments of Respiratory and Sleep Medicine (R.R.G.) and Neurology (C.S.A.), Royal Prince Alfred Hospital, Sydney Health Partners, Sydney, and the Western Australian Sleep Disorders Research Institute, Sir Charles Gairdner Hospital, Perth, WA (N.M., S.M.) - all in Australia; the First Affiliated Hospital of Guangzhou Medical University, State Key Laboratory of Respiratory Disease (Y.L., N.Z.), and Guangdong General Hospital and Guangdong Academy of Medical Sciences (Q.O.), Guangzhou, the First Affiliated Hospital of Nanjing Medical University, Nanjing (X.Z.), the Second Affiliated Hospital of Soochow University, Suzhou (R.C.), the Department of Cardiology, Fuwai Hospital (Z.L.), and George Institute for Global Health China (C.S.A.), Peking University Health Sciences Center, Beijing, the Department of Neurology, Xuzhou Central Hospital, Xuzhou (G.C.), Hejian Municipal People's Hospital, Hejian (B.D.), and Shanghai Institute of Hypertension, Ruijin Hospital, Shanghai Jiaotong University, Shanghai (J.W.) - all in China; University Hospital of Guadalajara, Guadalajara (O.M.), the Respiratory Department, Institut de Recerca Biomèdica de Lleida, Lleida (F.B.), and Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES), Madrid (F.B.) - all in Spain; Instituto do Coracao (Incor) and Hospital Universitario (L.F.D., G.L.-F.) and the Hypertension Unit, Renal Division, University of São Paulo Medical Sc
authors: Xilong
authors: X
authors: Zhang
authors: From the Adelaide Institute for Sleep Health (R.D.M., N.A.A.) and the School of Medicine, Faculty of Medicine, Nursing, and Health Sciences (R.D.M., N.A.A., E.H., B.N., C.S.A.), Flinders University, and Sleep Health Service, Respiratory and Sleep Services, Southern Adelaide Local Health Network (R.D.M., N.A.A., S.M.), Adelaide, SA, George Institute for Global Health (E.H., L.B., Q.L., H.A., B.N., C.S.A.), Sydney Medical School (E.H., L.B., Q.L., H.A., B.N., C.S.A.), and Woolcock Institute of Medical Research (R.R.G.), University of Sydney, and the Departments of Respiratory and Sleep Medicine (R.R.G.) and Neurology (C.S.A.), Royal Prince Alfred Hospital, Sydney Health Partners, Sydney, and the Western Australian Sleep Disorders Research Institute, Sir Charles Gairdner Hospital, Perth, WA (N.M., S.M.) - all in Australia; the First Affiliated Hospital of Guangzhou Medical University, State Key Laboratory of Respiratory Disease (Y.L., N.Z.), and Guangdong General Hospital and Guangdong Academy of Medical Sciences (Q.O.), Guangzhou, the First Affiliated Hospital of Nanjing Medical University, Nanjing (X.Z.), the Second Affiliated Hospital of Soochow University, Suzhou (R.C.), the Department of Cardiology, Fuwai Hospital (Z.L.), and George Institute for Global Health China (C.S.A.), Peking University Health Sciences Center, Beijing, the Department of Neurology, Xuzhou Central Hospital, Xuzhou (G.C.), Hejian Municipal People's Hospital, Hejian (B.D.), and Shanghai Institute of Hypertension, Ruijin Hospital, Shanghai Jiaotong University, Shanghai (J.W.) - all in China; University Hospital of Guadalajara, Guadalajara (O.M.), the Respiratory Department, Institut de Recerca Biomèdica de Lleida, Lleida (F.B.), and Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES), Madrid (F.B.) - all in Spain; Instituto do Coracao (Incor) and Hospital Universitario (L.F.D., G.L.-F.) and the Hypertension Unit, Renal Division, University of São Paulo Medical Sc
authors: Olga
authors: O
authors: Mediano
authors: From the Adelaide Institute for Sleep Health (R.D.M., N.A.A.) and the School of Medicine, Faculty of Medicine, Nursing, and Health Sciences (R.D.M., N.A.A., E.H., B.N., C.S.A.), Flinders University, and Sleep Health Service, Respiratory and Sleep Services, Southern Adelaide Local Health Network (R.D.M., N.A.A., S.M.), Adelaide, SA, George Institute for Global Health (E.H., L.B., Q.L., H.A., B.N., C.S.A.), Sydney Medical School (E.H., L.B., Q.L., H.A., B.N., C.S.A.), and Woolcock Institute of Medical Research (R.R.G.), University of Sydney, and the Departments of Respiratory and Sleep Medicine (R.R.G.) and Neurology (C.S.A.), Royal Prince Alfred Hospital, Sydney Health Partners, Sydney, and the Western Australian Sleep Disorders Research Institute, Sir Charles Gairdner Hospital, Perth, WA (N.M., S.M.) - all in Australia; the First Affiliated Hospital of Guangzhou Medical University, State Key Laboratory of Respiratory Disease (Y.L., N.Z.), and Guangdong General Hospital and Guangdong Academy of Medical Sciences (Q.O.), Guangzhou, the First Affiliated Hospital of Nanjing Medical University, Nanjing (X.Z.), the Second Affiliated Hospital of Soochow University, Suzhou (R.C.), the Department of Cardiology, Fuwai Hospital (Z.L.), and George Institute for Global Health China (C.S.A.), Peking University Health Sciences Center, Beijing, the Department of Neurology, Xuzhou Central Hospital, Xuzhou (G.C.), Hejian Municipal People's Hospital, Hejian (B.D.), and Shanghai Institute of Hypertension, Ruijin Hospital, Shanghai Jiaotong University, Shanghai (J.W.) - all in China; University Hospital of Guadalajara, Guadalajara (O.M.), the Respiratory Department, Institut de Recerca Biomèdica de Lleida, Lleida (F.B.), and Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES), Madrid (F.B.) - all in Spain; Instituto do Coracao (Incor) and Hospital Universitario (L.F.D., G.L.-F.) and the Hypertension Unit, Renal Division, University of São Paulo Medical Sc
authors: Rui
authors: R
authors: Chen
authors: From the Adelaide Institute for Sleep Health (R.D.M., N.A.A.) and the School of Medicine, Faculty of Medicine, Nursing, and Health Sciences (R.D.M., N.A.A., E.H., B.N., C.S.A.), Flinders University, and Sleep Health Service, Respiratory and Sleep Services, Southern Adelaide Local Health Network (R.D.M., N.A.A., S.M.), Adelaide, SA, George Institute for Global Health (E.H., L.B., Q.L., H.A., B.N., C.S.A.), Sydney Medical School (E.H., L.B., Q.L., H.A., B.N., C.S.A.), and Woolcock Institute of Medical Research (R.R.G.), University of Sydney, and the Departments of Respiratory and Sleep Medicine (R.R.G.) and Neurology (C.S.A.), Royal Prince Alfred Hospital, Sydney Health Partners, Sydney, and the Western Australian Sleep Disorders Research Institute, Sir Charles Gairdner Hospital, Perth, WA (N.M., S.M.) - all in Australia; the First Affiliated Hospital of Guangzhou Medical University, State Key Laboratory of Respiratory Disease (Y.L., N.Z.), and Guangdong General Hospital and Guangdong Academy of Medical Sciences (Q.O.), Guangzhou, the First Affiliated Hospital of Nanjing Medical University, Nanjing (X.Z.), the Second Affiliated Hospital of Soochow University, Suzhou (R.C.), the Department of Cardiology, Fuwai Hospital (Z.L.), and George Institute for Global Health China (C.S.A.), Peking University Health Sciences Center, Beijing, the Department of Neurology, Xuzhou Central Hospital, Xuzhou (G.C.), Hejian Municipal People's Hospital, Hejian (B.D.), and Shanghai Institute of Hypertension, Ruijin Hospital, Shanghai Jiaotong University, Shanghai (J.W.) - all in China; University Hospital of Guadalajara, Guadalajara (O.M.), the Respiratory Department, Institut de Recerca Biomèdica de Lleida, Lleida (F.B.), and Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES), Madrid (F.B.) - all in Spain; Instituto do Coracao (Incor) and Hospital Universitario (L.F.D., G.L.-F.) and the Hypertension Unit, Renal Division, University of São Paulo Medical Sc
authors: Luciano F
authors: LF
authors: Drager
authors: From the Adelaide Institute for Sleep Health (R.D.M., N.A.A.) and the School of Medicine, Faculty of Medicine, Nursing, and Health Sciences (R.D.M., N.A.A., E.H., B.N., C.S.A.), Flinders University, and Sleep Health Service, Respiratory and Sleep Services, Southern Adelaide Local Health Network (R.D.M., N.A.A., S.M.), Adelaide, SA, George Institute for Global Health (E.H., L.B., Q.L., H.A., B.N., C.S.A.), Sydney Medical School (E.H., L.B., Q.L., H.A., B.N., C.S.A.), and Woolcock Institute of Medical Research (R.R.G.), University of Sydney, and the Departments of Respiratory and Sleep Medicine (R.R.G.) and Neurology (C.S.A.), Royal Prince Alfred Hospital, Sydney Health Partners, Sydney, and the Western Australian Sleep Disorders Research Institute, Sir Charles Gairdner Hospital, Perth, WA (N.M., S.M.) - all in Australia; the First Affiliated Hospital of Guangzhou Medical University, State Key Laboratory of Respiratory Disease (Y.L., N.Z.), and Guangdong General Hospital and Guangdong Academy of Medical Sciences (Q.O.), Guangzhou, the First Affiliated Hospital of Nanjing Medical University, Nanjing (X.Z.), the Second Affiliated Hospital of Soochow University, Suzhou (R.C.), the Department of Cardiology, Fuwai Hospital (Z.L.), and George Institute for Global Health China (C.S.A.), Peking University Health Sciences Center, Beijing, the Department of Neurology, Xuzhou Central Hospital, Xuzhou (G.C.), Hejian Municipal People's Hospital, Hejian (B.D.), and Shanghai Institute of Hypertension, Ruijin Hospital, Shanghai Jiaotong University, Shanghai (J.W.) - all in China; University Hospital of Guadalajara, Guadalajara (O.M.), the Respiratory Department, Institut de Recerca Biomèdica de Lleida, Lleida (F.B.), and Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES), Madrid (F.B.) - all in Spain; Instituto do Coracao (Incor) and Hospital Universitario (L.F.D., G.L.-F.) and the Hypertension Unit, Renal Division, University of São Paulo Medical Sc
authors: Zhihong
authors: Z
authors: Liu
authors: From the Adelaide Institute for Sleep Health (R.D.M., N.A.A.) and the School of Medicine, Faculty of Medicine, Nursing, and Health Sciences (R.D.M., N.A.A., E.H., B.N., C.S.A.), Flinders University, and Sleep Health Service, Respiratory and Sleep Services, Southern Adelaide Local Health Network (R.D.M., N.A.A., S.M.), Adelaide, SA, George Institute for Global Health (E.H., L.B., Q.L., H.A., B.N., C.S.A.), Sydney Medical School (E.H., L.B., Q.L., H.A., B.N., C.S.A.), and Woolcock Institute of Medical Research (R.R.G.), University of Sydney, and the Departments of Respiratory and Sleep Medicine (R.R.G.) and Neurology (C.S.A.), Royal Prince Alfred Hospital, Sydney Health Partners, Sydney, and the Western Australian Sleep Disorders Research Institute, Sir Charles Gairdner Hospital, Perth, WA (N.M., S.M.) - all in Australia; the First Affiliated Hospital of Guangzhou Medical University, State Key Laboratory of Respiratory Disease (Y.L., N.Z.), and Guangdong General Hospital and Guangdong Academy of Medical Sciences (Q.O.), Guangzhou, the First Affiliated Hospital of Nanjing Medical University, Nanjing (X.Z.), the Second Affiliated Hospital of Soochow University, Suzhou (R.C.), the Department of Cardiology, Fuwai Hospital (Z.L.), and George Institute for Global Health China (C.S.A.), Peking University Health Sciences Center, Beijing, the Department of Neurology, Xuzhou Central Hospital, Xuzhou (G.C.), Hejian Municipal People's Hospital, Hejian (B.D.), and Shanghai Institute of Hypertension, Ruijin Hospital, Shanghai Jiaotong University, Shanghai (J.W.) - all in China; University Hospital of Guadalajara, Guadalajara (O.M.), the Respiratory Department, Institut de Recerca Biomèdica de Lleida, Lleida (F.B.), and Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES), Madrid (F.B.) - all in Spain; Instituto do Coracao (Incor) and Hospital Universitario (L.F.D., G.L.-F.) and the Hypertension Unit, Renal Division, University of São Paulo Medical Sc
authors: Guofang
authors: G
authors: Chen
authors: From the Adelaide Institute for Sleep Health (R.D.M., N.A.A.) and the School of Medicine, Faculty of Medicine, Nursing, and Health Sciences (R.D.M., N.A.A., E.H., B.N., C.S.A.), Flinders University, and Sleep Health Service, Respiratory and Sleep Services, Southern Adelaide Local Health Network (R.D.M., N.A.A., S.M.), Adelaide, SA, George Institute for Global Health (E.H., L.B., Q.L., H.A., B.N., C.S.A.), Sydney Medical School (E.H., L.B., Q.L., H.A., B.N., C.S.A.), and Woolcock Institute of Medical Research (R.R.G.), University of Sydney, and the Departments of Respiratory and Sleep Medicine (R.R.G.) and Neurology (C.S.A.), Royal Prince Alfred Hospital, Sydney Health Partners, Sydney, and the Western Australian Sleep Disorders Research Institute, Sir Charles Gairdner Hospital, Perth, WA (N.M., S.M.) - all in Australia; the First Affiliated Hospital of Guangzhou Medical University, State Key Laboratory of Respiratory Disease (Y.L., N.Z.), and Guangdong General Hospital and Guangdong Academy of Medical Sciences (Q.O.), Guangzhou, the First Affiliated Hospital of Nanjing Medical University, Nanjing (X.Z.), the Second Affiliated Hospital of Soochow University, Suzhou (R.C.), the Department of Cardiology, Fuwai Hospital (Z.L.), and George Institute for Global Health China (C.S.A.), Peking University Health Sciences Center, Beijing, the Department of Neurology, Xuzhou Central Hospital, Xuzhou (G.C.), Hejian Municipal People's Hospital, Hejian (B.D.), and Shanghai Institute of Hypertension, Ruijin Hospital, Shanghai Jiaotong University, Shanghai (J.W.) - all in China; University Hospital of Guadalajara, Guadalajara (O.M.), the Respiratory Department, Institut de Recerca Biomèdica de Lleida, Lleida (F.B.), and Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES), Madrid (F.B.) - all in Spain; Instituto do Coracao (Incor) and Hospital Universitario (L.F.D., G.L.-F.) and the Hypertension Unit, Renal Division, University of São Paulo Medical Sc
authors: Baoliang
authors: B
authors: Du
authors: From the Adelaide Institute for Sleep Health (R.D.M., N.A.A.) and the School of Medicine, Faculty of Medicine, Nursing, and Health Sciences (R.D.M., N.A.A., E.H., B.N., C.S.A.), Flinders University, and Sleep Health Service, Respiratory and Sleep Services, Southern Adelaide Local Health Network (R.D.M., N.A.A., S.M.), Adelaide, SA, George Institute for Global Health (E.H., L.B., Q.L., H.A., B.N., C.S.A.), Sydney Medical School (E.H., L.B., Q.L., H.A., B.N., C.S.A.), and Woolcock Institute of Medical Research (R.R.G.), University of Sydney, and the Departments of Respiratory and Sleep Medicine (R.R.G.) and Neurology (C.S.A.), Royal Prince Alfred Hospital, Sydney Health Partners, Sydney, and the Western Australian Sleep Disorders Research Institute, Sir Charles Gairdner Hospital, Perth, WA (N.M., S.M.) - all in Australia; the First Affiliated Hospital of Guangzhou Medical University, State Key Laboratory of Respiratory Disease (Y.L., N.Z.), and Guangdong General Hospital and Guangdong Academy of Medical Sciences (Q.O.), Guangzhou, the First Affiliated Hospital of Nanjing Medical University, Nanjing (X.Z.), the Second Affiliated Hospital of Soochow University, Suzhou (R.C.), the Department of Cardiology, Fuwai Hospital (Z.L.), and George Institute for Global Health China (C.S.A.), Peking University Health Sciences Center, Beijing, the Department of Neurology, Xuzhou Central Hospital, Xuzhou (G.C.), Hejian Municipal People's Hospital, Hejian (B.D.), and Shanghai Institute of Hypertension, Ruijin Hospital, Shanghai Jiaotong University, Shanghai (J.W.) - all in China; University Hospital of Guadalajara, Guadalajara (O.M.), the Respiratory Department, Institut de Recerca Biomèdica de Lleida, Lleida (F.B.), and Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES), Madrid (F.B.) - all in Spain; Instituto do Coracao (Incor) and Hospital Universitario (L.F.D., G.L.-F.) and the Hypertension Unit, Renal Division, University of São Paulo Medical Sc
authors: Nigel
authors: N
authors: McArdle
authors: From the Adelaide Institute for Sleep Health (R.D.M., N.A.A.) and the School of Medicine, Faculty of Medicine, Nursing, and Health Sciences (R.D.M., N.A.A., E.H., B.N., C.S.A.), Flinders University, and Sleep Health Service, Respiratory and Sleep Services, Southern Adelaide Local Health Network (R.D.M., N.A.A., S.M.), Adelaide, SA, George Institute for Global Health (E.H., L.B., Q.L., H.A., B.N., C.S.A.), Sydney Medical School (E.H., L.B., Q.L., H.A., B.N., C.S.A.), and Woolcock Institute of Medical Research (R.R.G.), University of Sydney, and the Departments of Respiratory and Sleep Medicine (R.R.G.) and Neurology (C.S.A.), Royal Prince Alfred Hospital, Sydney Health Partners, Sydney, and the Western Australian Sleep Disorders Research Institute, Sir Charles Gairdner Hospital, Perth, WA (N.M., S.M.) - all in Australia; the First Affiliated Hospital of Guangzhou Medical University, State Key Laboratory of Respiratory Disease (Y.L., N.Z.), and Guangdong General Hospital and Guangdong Academy of Medical Sciences (Q.O.), Guangzhou, the First Affiliated Hospital of Nanjing Medical University, Nanjing (X.Z.), the Second Affiliated Hospital of Soochow University, Suzhou (R.C.), the Department of Cardiology, Fuwai Hospital (Z.L.), and George Institute for Global Health China (C.S.A.), Peking University Health Sciences Center, Beijing, the Department of Neurology, Xuzhou Central Hospital, Xuzhou (G.C.), Hejian Municipal People's Hospital, Hejian (B.D.), and Shanghai Institute of Hypertension, Ruijin Hospital, Shanghai Jiaotong University, Shanghai (J.W.) - all in China; University Hospital of Guadalajara, Guadalajara (O.M.), the Respiratory Department, Institut de Recerca Biomèdica de Lleida, Lleida (F.B.), and Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES), Madrid (F.B.) - all in Spain; Instituto do Coracao (Incor) and Hospital Universitario (L.F.D., G.L.-F.) and the Hypertension Unit, Renal Division, University of São Paulo Medical Sc
authors: Sutapa
authors: S
authors: Mukherjee
authors: From the Adelaide Institute for Sleep Health (R.D.M., N.A.A.) and the School of Medicine, Faculty of Medicine, Nursing, and Health Sciences (R.D.M., N.A.A., E.H., B.N., C.S.A.), Flinders University, and Sleep Health Service, Respiratory and Sleep Services, Southern Adelaide Local Health Network (R.D.M., N.A.A., S.M.), Adelaide, SA, George Institute for Global Health (E.H., L.B., Q.L., H.A., B.N., C.S.A.), Sydney Medical School (E.H., L.B., Q.L., H.A., B.N., C.S.A.), and Woolcock Institute of Medical Research (R.R.G.), University of Sydney, and the Departments of Respiratory and Sleep Medicine (R.R.G.) and Neurology (C.S.A.), Royal Prince Alfred Hospital, Sydney Health Partners, Sydney, and the Western Australian Sleep Disorders Research Institute, Sir Charles Gairdner Hospital, Perth, WA (N.M., S.M.) - all in Australia; the First Affiliated Hospital of Guangzhou Medical University, State Key Laboratory of Respiratory Disease (Y.L., N.Z.), and Guangdong General Hospital and Guangdong Academy of Medical Sciences (Q.O.), Guangzhou, the First Affiliated Hospital of Nanjing Medical University, Nanjing (X.Z.), the Second Affiliated Hospital of Soochow University, Suzhou (R.C.), the Department of Cardiology, Fuwai Hospital (Z.L.), and George Institute for Global Health China (C.S.A.), Peking University Health Sciences Center, Beijing, the Department of Neurology, Xuzhou Central Hospital, Xuzhou (G.C.), Hejian Municipal People's Hospital, Hejian (B.D.), and Shanghai Institute of Hypertension, Ruijin Hospital, Shanghai Jiaotong University, Shanghai (J.W.) - all in China; University Hospital of Guadalajara, Guadalajara (O.M.), the Respiratory Department, Institut de Recerca Biomèdica de Lleida, Lleida (F.B.), and Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES), Madrid (F.B.) - all in Spain; Instituto do Coracao (Incor) and Hospital Universitario (L.F.D., G.L.-F.) and the Hypertension Unit, Renal Division, University of São Paulo Medical Sc
authors: Manjari
authors: M
authors: Tripathi
authors: From the Adelaide Institute for Sleep Health (R.D.M., N.A.A.) and the School of Medicine, Faculty of Medicine, Nursing, and Health Sciences (R.D.M., N.A.A., E.H., B.N., C.S.A.), Flinders University, and Sleep Health Service, Respiratory and Sleep Services, Southern Adelaide Local Health Network (R.D.M., N.A.A., S.M.), Adelaide, SA, George Institute for Global Health (E.H., L.B., Q.L., H.A., B.N., C.S.A.), Sydney Medical School (E.H., L.B., Q.L., H.A., B.N., C.S.A.), and Woolcock Institute of Medical Research (R.R.G.), University of Sydney, and the Departments of Respiratory and Sleep Medicine (R.R.G.) and Neurology (C.S.A.), Royal Prince Alfred Hospital, Sydney Health Partners, Sydney, and the Western Australian Sleep Disorders Research Institute, Sir Charles Gairdner Hospital, Perth, WA (N.M., S.M.) - all in Australia; the First Affiliated Hospital of Guangzhou Medical University, State Key Laboratory of Respiratory Disease (Y.L., N.Z.), and Guangdong General Hospital and Guangdong Academy of Medical Sciences (Q.O.), Guangzhou, the First Affiliated Hospital of Nanjing Medical University, Nanjing (X.Z.), the Second Affiliated Hospital of Soochow University, Suzhou (R.C.), the Department of Cardiology, Fuwai Hospital (Z.L.), and George Institute for Global Health China (C.S.A.), Peking University Health Sciences Center, Beijing, the Department of Neurology, Xuzhou Central Hospital, Xuzhou (G.C.), Hejian Municipal People's Hospital, Hejian (B.D.), and Shanghai Institute of Hypertension, Ruijin Hospital, Shanghai Jiaotong University, Shanghai (J.W.) - all in China; University Hospital of Guadalajara, Guadalajara (O.M.), the Respiratory Department, Institut de Recerca Biomèdica de Lleida, Lleida (F.B.), and Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES), Madrid (F.B.) - all in Spain; Instituto do Coracao (Incor) and Hospital Universitario (L.F.D., G.L.-F.) and the Hypertension Unit, Renal Division, University of São Paulo Medical Sc
authors: Laurent
authors: L
authors: Billot
authors: From the Adelaide Institute for Sleep Health (R.D.M., N.A.A.) and the School of Medicine, Faculty of Medicine, Nursing, and Health Sciences (R.D.M., N.A.A., E.H., B.N., C.S.A.), Flinders University, and Sleep Health Service, Respiratory and Sleep Services, Southern Adelaide Local Health Network (R.D.M., N.A.A., S.M.), Adelaide, SA, George Institute for Global Health (E.H., L.B., Q.L., H.A., B.N., C.S.A.), Sydney Medical School (E.H., L.B., Q.L., H.A., B.N., C.S.A.), and Woolcock Institute of Medical Research (R.R.G.), University of Sydney, and the Departments of Respiratory and Sleep Medicine (R.R.G.) and Neurology (C.S.A.), Royal Prince Alfred Hospital, Sydney Health Partners, Sydney, and the Western Australian Sleep Disorders Research Institute, Sir Charles Gairdner Hospital, Perth, WA (N.M., S.M.) - all in Australia; the First Affiliated Hospital of Guangzhou Medical University, State Key Laboratory of Respiratory Disease (Y.L., N.Z.), and Guangdong General Hospital and Guangdong Academy of Medical Sciences (Q.O.), Guangzhou, the First Affiliated Hospital of Nanjing Medical University, Nanjing (X.Z.), the Second Affiliated Hospital of Soochow University, Suzhou (R.C.), the Department of Cardiology, Fuwai Hospital (Z.L.), and George Institute for Global Health China (C.S.A.), Peking University Health Sciences Center, Beijing, the Department of Neurology, Xuzhou Central Hospital, Xuzhou (G.C.), Hejian Municipal People's Hospital, Hejian (B.D.), and Shanghai Institute of Hypertension, Ruijin Hospital, Shanghai Jiaotong University, Shanghai (J.W.) - all in China; University Hospital of Guadalajara, Guadalajara (O.M.), the Respiratory Department, Institut de Recerca Biomèdica de Lleida, Lleida (F.B.), and Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES), Madrid (F.B.) - all in Spain; Instituto do Coracao (Incor) and Hospital Universitario (L.F.D., G.L.-F.) and the Hypertension Unit, Renal Division, University of São Paulo Medical Sc
authors: Qiang
authors: Q
authors: Li
authors: From the Adelaide Institute for Sleep Health (R.D.M., N.A.A.) and the School of Medicine, Faculty of Medicine, Nursing, and Health Sciences (R.D.M., N.A.A., E.H., B.N., C.S.A.), Flinders University, and Sleep Health Service, Respiratory and Sleep Services, Southern Adelaide Local Health Network (R.D.M., N.A.A., S.M.), Adelaide, SA, George Institute for Global Health (E.H., L.B., Q.L., H.A., B.N., C.S.A.), Sydney Medical School (E.H., L.B., Q.L., H.A., B.N., C.S.A.), and Woolcock Institute of Medical Research (R.R.G.), University of Sydney, and the Departments of Respiratory and Sleep Medicine (R.R.G.) and Neurology (C.S.A.), Royal Prince Alfred Hospital, Sydney Health Partners, Sydney, and the Western Australian Sleep Disorders Research Institute, Sir Charles Gairdner Hospital, Perth, WA (N.M., S.M.) - all in Australia; the First Affiliated Hospital of Guangzhou Medical University, State Key Laboratory of Respiratory Disease (Y.L., N.Z.), and Guangdong General Hospital and Guangdong Academy of Medical Sciences (Q.O.), Guangzhou, the First Affiliated Hospital of Nanjing Medical University, Nanjing (X.Z.), the Second Affiliated Hospital of Soochow University, Suzhou (R.C.), the Department of Cardiology, Fuwai Hospital (Z.L.), and George Institute for Global Health China (C.S.A.), Peking University Health Sciences Center, Beijing, the Department of Neurology, Xuzhou Central Hospital, Xuzhou (G.C.), Hejian Municipal People's Hospital, Hejian (B.D.), and Shanghai Institute of Hypertension, Ruijin Hospital, Shanghai Jiaotong University, Shanghai (J.W.) - all in China; University Hospital of Guadalajara, Guadalajara (O.M.), the Respiratory Department, Institut de Recerca Biomèdica de Lleida, Lleida (F.B.), and Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES), Madrid (F.B.) - all in Spain; Instituto do Coracao (Incor) and Hospital Universitario (L.F.D., G.L.-F.) and the Hypertension Unit, Renal Division, University of São Paulo Medical Sc
authors: Geraldo
authors: G
authors: Lorenzi-Filho
authors: From the Adelaide Institute for Sleep Health (R.D.M., N.A.A.) and the School of Medicine, Faculty of Medicine, Nursing, and Health Sciences (R.D.M., N.A.A., E.H., B.N., C.S.A.), Flinders University, and Sleep Health Service, Respiratory and Sleep Services, Southern Adelaide Local Health Network (R.D.M., N.A.A., S.M.), Adelaide, SA, George Institute for Global Health (E.H., L.B., Q.L., H.A., B.N., C.S.A.), Sydney Medical School (E.H., L.B., Q.L., H.A., B.N., C.S.A.), and Woolcock Institute of Medical Research (R.R.G.), University of Sydney, and the Departments of Respiratory and Sleep Medicine (R.R.G.) and Neurology (C.S.A.), Royal Prince Alfred Hospital, Sydney Health Partners, Sydney, and the Western Australian Sleep Disorders Research Institute, Sir Charles Gairdner Hospital, Perth, WA (N.M., S.M.) - all in Australia; the First Affiliated Hospital of Guangzhou Medical University, State Key Laboratory of Respiratory Disease (Y.L., N.Z.), and Guangdong General Hospital and Guangdong Academy of Medical Sciences (Q.O.), Guangzhou, the First Affiliated Hospital of Nanjing Medical University, Nanjing (X.Z.), the Second Affiliated Hospital of Soochow University, Suzhou (R.C.), the Department of Cardiology, Fuwai Hospital (Z.L.), and George Institute for Global Health China (C.S.A.), Peking University Health Sciences Center, Beijing, the Department of Neurology, Xuzhou Central Hospital, Xuzhou (G.C.), Hejian Municipal People's Hospital, Hejian (B.D.), and Shanghai Institute of Hypertension, Ruijin Hospital, Shanghai Jiaotong University, Shanghai (J.W.) - all in China; University Hospital of Guadalajara, Guadalajara (O.M.), the Respiratory Department, Institut de Recerca Biomèdica de Lleida, Lleida (F.B.), and Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES), Madrid (F.B.) - all in Spain; Instituto do Coracao (Incor) and Hospital Universitario (L.F.D., G.L.-F.) and the Hypertension Unit, Renal Division, University of São Paulo Medical Sc
authors: Ferran
authors: F
authors: Barbe
authors: From the Adelaide Institute for Sleep Health (R.D.M., N.A.A.) and the School of Medicine, Faculty of Medicine, Nursing, and Health Sciences (R.D.M., N.A.A., E.H., B.N., C.S.A.), Flinders University, and Sleep Health Service, Respiratory and Sleep Services, Southern Adelaide Local Health Network (R.D.M., N.A.A., S.M.), Adelaide, SA, George Institute for Global Health (E.H., L.B., Q.L., H.A., B.N., C.S.A.), Sydney Medical School (E.H., L.B., Q.L., H.A., B.N., C.S.A.), and Woolcock Institute of Medical Research (R.R.G.), University of Sydney, and the Departments of Respiratory and Sleep Medicine (R.R.G.) and Neurology (C.S.A.), Royal Prince Alfred Hospital, Sydney Health Partners, Sydney, and the Western Australian Sleep Disorders Research Institute, Sir Charles Gairdner Hospital, Perth, WA (N.M., S.M.) - all in Australia; the First Affiliated Hospital of Guangzhou Medical University, State Key Laboratory of Respiratory Disease (Y.L., N.Z.), and Guangdong General Hospital and Guangdong Academy of Medical Sciences (Q.O.), Guangzhou, the First Affiliated Hospital of Nanjing Medical University, Nanjing (X.Z.), the Second Affiliated Hospital of Soochow University, Suzhou (R.C.), the Department of Cardiology, Fuwai Hospital (Z.L.), and George Institute for Global Health China (C.S.A.), Peking University Health Sciences Center, Beijing, the Department of Neurology, Xuzhou Central Hospital, Xuzhou (G.C.), Hejian Municipal People's Hospital, Hejian (B.D.), and Shanghai Institute of Hypertension, Ruijin Hospital, Shanghai Jiaotong University, Shanghai (J.W.) - all in China; University Hospital of Guadalajara, Guadalajara (O.M.), the Respiratory Department, Institut de Recerca Biomèdica de Lleida, Lleida (F.B.), and Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES), Madrid (F.B.) - all in Spain; Instituto do Coracao (Incor) and Hospital Universitario (L.F.D., G.L.-F.) and the Hypertension Unit, Renal Division, University of São Paulo Medical Sc
authors: Susan
authors: S
authors: Redline
authors: From the Adelaide Institute for Sleep Health (R.D.M., N.A.A.) and the School of Medicine, Faculty of Medicine, Nursing, and Health Sciences (R.D.M., N.A.A., E.H., B.N., C.S.A.), Flinders University, and Sleep Health Service, Respiratory and Sleep Services, Southern Adelaide Local Health Network (R.D.M., N.A.A., S.M.), Adelaide, SA, George Institute for Global Health (E.H., L.B., Q.L., H.A., B.N., C.S.A.), Sydney Medical School (E.H., L.B., Q.L., H.A., B.N., C.S.A.), and Woolcock Institute of Medical Research (R.R.G.), University of Sydney, and the Departments of Respiratory and Sleep Medicine (R.R.G.) and Neurology (C.S.A.), Royal Prince Alfred Hospital, Sydney Health Partners, Sydney, and the Western Australian Sleep Disorders Research Institute, Sir Charles Gairdner Hospital, Perth, WA (N.M., S.M.) - all in Australia; the First Affiliated Hospital of Guangzhou Medical University, State Key Laboratory of Respiratory Disease (Y.L., N.Z.), and Guangdong General Hospital and Guangdong Academy of Medical Sciences (Q.O.), Guangzhou, the First Affiliated Hospital of Nanjing Medical University, Nanjing (X.Z.), the Second Affiliated Hospital of Soochow University, Suzhou (R.C.), the Department of Cardiology, Fuwai Hospital (Z.L.), and George Institute for Global Health China (C.S.A.), Peking University Health Sciences Center, Beijing, the Department of Neurology, Xuzhou Central Hospital, Xuzhou (G.C.), Hejian Municipal People's Hospital, Hejian (B.D.), and Shanghai Institute of Hypertension, Ruijin Hospital, Shanghai Jiaotong University, Shanghai (J.W.) - all in China; University Hospital of Guadalajara, Guadalajara (O.M.), the Respiratory Department, Institut de Recerca Biomèdica de Lleida, Lleida (F.B.), and Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES), Madrid (F.B.) - all in Spain; Instituto do Coracao (Incor) and Hospital Universitario (L.F.D., G.L.-F.) and the Hypertension Unit, Renal Division, University of São Paulo Medical Sc
authors: Jiguang
authors: J
authors: Wang
authors: From the Adelaide Institute for Sleep Health (R.D.M., N.A.A.) and the School of Medicine, Faculty of Medicine, Nursing, and Health Sciences (R.D.M., N.A.A., E.H., B.N., C.S.A.), Flinders University, and Sleep Health Service, Respiratory and Sleep Services, Southern Adelaide Local Health Network (R.D.M., N.A.A., S.M.), Adelaide, SA, George Institute for Global Health (E.H., L.B., Q.L., H.A., B.N., C.S.A.), Sydney Medical School (E.H., L.B., Q.L., H.A., B.N., C.S.A.), and Woolcock Institute of Medical Research (R.R.G.), University of Sydney, and the Departments of Respiratory and Sleep Medicine (R.R.G.) and Neurology (C.S.A.), Royal Prince Alfred Hospital, Sydney Health Partners, Sydney, and the Western Australian Sleep Disorders Research Institute, Sir Charles Gairdner Hospital, Perth, WA (N.M., S.M.) - all in Australia; the First Affiliated Hospital of Guangzhou Medical University, State Key Laboratory of Respiratory Disease (Y.L., N.Z.), and Guangdong General Hospital and Guangdong Academy of Medical Sciences (Q.O.), Guangzhou, the First Affiliated Hospital of Nanjing Medical University, Nanjing (X.Z.), the Second Affiliated Hospital of Soochow University, Suzhou (R.C.), the Department of Cardiology, Fuwai Hospital (Z.L.), and George Institute for Global Health China (C.S.A.), Peking University Health Sciences Center, Beijing, the Department of Neurology, Xuzhou Central Hospital, Xuzhou (G.C.), Hejian Municipal People's Hospital, Hejian (B.D.), and Shanghai Institute of Hypertension, Ruijin Hospital, Shanghai Jiaotong University, Shanghai (J.W.) - all in China; University Hospital of Guadalajara, Guadalajara (O.M.), the Respiratory Department, Institut de Recerca Biomèdica de Lleida, Lleida (F.B.), and Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES), Madrid (F.B.) - all in Spain; Instituto do Coracao (Incor) and Hospital Universitario (L.F.D., G.L.-F.) and the Hypertension Unit, Renal Division, University of São Paulo Medical Sc
authors: Hisatomi
authors: H
authors: Arima
authors: From the Adelaide Institute for Sleep Health (R.D.M., N.A.A.) and the School of Medicine, Faculty of Medicine, Nursing, and Health Sciences (R.D.M., N.A.A., E.H., B.N., C.S.A.), Flinders University, and Sleep Health Service, Respiratory and Sleep Services, Southern Adelaide Local Health Network (R.D.M., N.A.A., S.M.), Adelaide, SA, George Institute for Global Health (E.H., L.B., Q.L., H.A., B.N., C.S.A.), Sydney Medical School (E.H., L.B., Q.L., H.A., B.N., C.S.A.), and Woolcock Institute of Medical Research (R.R.G.), University of Sydney, and the Departments of Respiratory and Sleep Medicine (R.R.G.) and Neurology (C.S.A.), Royal Prince Alfred Hospital, Sydney Health Partners, Sydney, and the Western Australian Sleep Disorders Research Institute, Sir Charles Gairdner Hospital, Perth, WA (N.M., S.M.) - all in Australia; the First Affiliated Hospital of Guangzhou Medical University, State Key Laboratory of Respiratory Disease (Y.L., N.Z.), and Guangdong General Hospital and Guangdong Academy of Medical Sciences (Q.O.), Guangzhou, the First Affiliated Hospital of Nanjing Medical University, Nanjing (X.Z.), the Second Affiliated Hospital of Soochow University, Suzhou (R.C.), the Department of Cardiology, Fuwai Hospital (Z.L.), and George Institute for Global Health China (C.S.A.), Peking University Health Sciences Center, Beijing, the Department of Neurology, Xuzhou Central Hospital, Xuzhou (G.C.), Hejian Municipal People's Hospital, Hejian (B.D.), and Shanghai Institute of Hypertension, Ruijin Hospital, Shanghai Jiaotong University, Shanghai (J.W.) - all in China; University Hospital of Guadalajara, Guadalajara (O.M.), the Respiratory Department, Institut de Recerca Biomèdica de Lleida, Lleida (F.B.), and Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES), Madrid (F.B.) - all in Spain; Instituto do Coracao (Incor) and Hospital Universitario (L.F.D., G.L.-F.) and the Hypertension Unit, Renal Division, University of São Paulo Medical Sc
authors: Bruce
authors: B
authors: Neal
authors: From the Adelaide Institute for Sleep Health (R.D.M., N.A.A.) and the School of Medicine, Faculty of Medicine, Nursing, and Health Sciences (R.D.M., N.A.A., E.H., B.N., C.S.A.), Flinders University, and Sleep Health Service, Respiratory and Sleep Services, Southern Adelaide Local Health Network (R.D.M., N.A.A., S.M.), Adelaide, SA, George Institute for Global Health (E.H., L.B., Q.L., H.A., B.N., C.S.A.), Sydney Medical School (E.H., L.B., Q.L., H.A., B.N., C.S.A.), and Woolcock Institute of Medical Research (R.R.G.), University of Sydney, and the Departments of Respiratory and Sleep Medicine (R.R.G.) and Neurology (C.S.A.), Royal Prince Alfred Hospital, Sydney Health Partners, Sydney, and the Western Australian Sleep Disorders Research Institute, Sir Charles Gairdner Hospital, Perth, WA (N.M., S.M.) - all in Australia; the First Affiliated Hospital of Guangzhou Medical University, State Key Laboratory of Respiratory Disease (Y.L., N.Z.), and Guangdong General Hospital and Guangdong Academy of Medical Sciences (Q.O.), Guangzhou, the First Affiliated Hospital of Nanjing Medical University, Nanjing (X.Z.), the Second Affiliated Hospital of Soochow University, Suzhou (R.C.), the Department of Cardiology, Fuwai Hospital (Z.L.), and George Institute for Global Health China (C.S.A.), Peking University Health Sciences Center, Beijing, the Department of Neurology, Xuzhou Central Hospital, Xuzhou (G.C.), Hejian Municipal People's Hospital, Hejian (B.D.), and Shanghai Institute of Hypertension, Ruijin Hospital, Shanghai Jiaotong University, Shanghai (J.W.) - all in China; University Hospital of Guadalajara, Guadalajara (O.M.), the Respiratory Department, Institut de Recerca Biomèdica de Lleida, Lleida (F.B.), and Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES), Madrid (F.B.) - all in Spain; Instituto do Coracao (Incor) and Hospital Universitario (L.F.D., G.L.-F.) and the Hypertension Unit, Renal Division, University of São Paulo Medical Sc
authors: David P
authors: DP
authors: White
authors: From the Adelaide Institute for Sleep Health (R.D.M., N.A.A.) and the School of Medicine, Faculty of Medicine, Nursing, and Health Sciences (R.D.M., N.A.A., E.H., B.N., C.S.A.), Flinders University, and Sleep Health Service, Respiratory and Sleep Services, Southern Adelaide Local Health Network (R.D.M., N.A.A., S.M.), Adelaide, SA, George Institute for Global Health (E.H., L.B., Q.L., H.A., B.N., C.S.A.), Sydney Medical School (E.H., L.B., Q.L., H.A., B.N., C.S.A.), and Woolcock Institute of Medical Research (R.R.G.), University of Sydney, and the Departments of Respiratory and Sleep Medicine (R.R.G.) and Neurology (C.S.A.), Royal Prince Alfred Hospital, Sydney Health Partners, Sydney, and the Western Australian Sleep Disorders Research Institute, Sir Charles Gairdner Hospital, Perth, WA (N.M., S.M.) - all in Australia; the First Affiliated Hospital of Guangzhou Medical University, State Key Laboratory of Respiratory Disease (Y.L., N.Z.), and Guangdong General Hospital and Guangdong Academy of Medical Sciences (Q.O.), Guangzhou, the First Affiliated Hospital of Nanjing Medical University, Nanjing (X.Z.), the Second Affiliated Hospital of Soochow University, Suzhou (R.C.), the Department of Cardiology, Fuwai Hospital (Z.L.), and George Institute for Global Health China (C.S.A.), Peking University Health Sciences Center, Beijing, the Department of Neurology, Xuzhou Central Hospital, Xuzhou (G.C.), Hejian Municipal People's Hospital, Hejian (B.D.), and Shanghai Institute of Hypertension, Ruijin Hospital, Shanghai Jiaotong University, Shanghai (J.W.) - all in China; University Hospital of Guadalajara, Guadalajara (O.M.), the Respiratory Department, Institut de Recerca Biomèdica de Lleida, Lleida (F.B.), and Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES), Madrid (F.B.) - all in Spain; Instituto do Coracao (Incor) and Hospital Universitario (L.F.D., G.L.-F.) and the Hypertension Unit, Renal Division, University of São Paulo Medical Sc
authors: Ron R
authors: RR
authors: Grunstein
authors: From the Adelaide Institute for Sleep Health (R.D.M., N.A.A.) and the School of Medicine, Faculty of Medicine, Nursing, and Health Sciences (R.D.M., N.A.A., E.H., B.N., C.S.A.), Flinders University, and Sleep Health Service, Respiratory and Sleep Services, Southern Adelaide Local Health Network (R.D.M., N.A.A., S.M.), Adelaide, SA, George Institute for Global Health (E.H., L.B., Q.L., H.A., B.N., C.S.A.), Sydney Medical School (E.H., L.B., Q.L., H.A., B.N., C.S.A.), and Woolcock Institute of Medical Research (R.R.G.), University of Sydney, and the Departments of Respiratory and Sleep Medicine (R.R.G.) and Neurology (C.S.A.), Royal Prince Alfred Hospital, Sydney Health Partners, Sydney, and the Western Australian Sleep Disorders Research Institute, Sir Charles Gairdner Hospital, Perth, WA (N.M., S.M.) - all in Australia; the First Affiliated Hospital of Guangzhou Medical University, State Key Laboratory of Respiratory Disease (Y.L., N.Z.), and Guangdong General Hospital and Guangdong Academy of Medical Sciences (Q.O.), Guangzhou, the First Affiliated Hospital of Nanjing Medical University, Nanjing (X.Z.), the Second Affiliated Hospital of Soochow University, Suzhou (R.C.), the Department of Cardiology, Fuwai Hospital (Z.L.), and George Institute for Global Health China (C.S.A.), Peking University Health Sciences Center, Beijing, the Department of Neurology, Xuzhou Central Hospital, Xuzhou (G.C.), Hejian Municipal People's Hospital, Hejian (B.D.), and Shanghai Institute of Hypertension, Ruijin Hospital, Shanghai Jiaotong University, Shanghai (J.W.) - all in China; University Hospital of Guadalajara, Guadalajara (O.M.), the Respiratory Department, Institut de Recerca Biomèdica de Lleida, Lleida (F.B.), and Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES), Madrid (F.B.) - all in Spain; Instituto do Coracao (Incor) and Hospital Universitario (L.F.D., G.L.-F.) and the Hypertension Unit, Renal Division, University of São Paulo Medical Sc
authors: Nanshan
authors: N
authors: Zhong
authors: From the Adelaide Institute for Sleep Health (R.D.M., N.A.A.) and the School of Medicine, Faculty of Medicine, Nursing, and Health Sciences (R.D.M., N.A.A., E.H., B.N., C.S.A.), Flinders University, and Sleep Health Service, Respiratory and Sleep Services, Southern Adelaide Local Health Network (R.D.M., N.A.A., S.M.), Adelaide, SA, George Institute for Global Health (E.H., L.B., Q.L., H.A., B.N., C.S.A.), Sydney Medical School (E.H., L.B., Q.L., H.A., B.N., C.S.A.), and Woolcock Institute of Medical Research (R.R.G.), University of Sydney, and the Departments of Respiratory and Sleep Medicine (R.R.G.) and Neurology (C.S.A.), Royal Prince Alfred Hospital, Sydney Health Partners, Sydney, and the Western Australian Sleep Disorders Research Institute, Sir Charles Gairdner Hospital, Perth, WA (N.M., S.M.) - all in Australia; the First Affiliated Hospital of Guangzhou Medical University, State Key Laboratory of Respiratory Disease (Y.L., N.Z.), and Guangdong General Hospital and Guangdong Academy of Medical Sciences (Q.O.), Guangzhou, the First Affiliated Hospital of Nanjing Medical University, Nanjing (X.Z.), the Second Affiliated Hospital of Soochow University, Suzhou (R.C.), the Department of Cardiology, Fuwai Hospital (Z.L.), and George Institute for Global Health China (C.S.A.), Peking University Health Sciences Center, Beijing, the Department of Neurology, Xuzhou Central Hospital, Xuzhou (G.C.), Hejian Municipal People's Hospital, Hejian (B.D.), and Shanghai Institute of Hypertension, Ruijin Hospital, Shanghai Jiaotong University, Shanghai (J.W.) - all in China; University Hospital of Guadalajara, Guadalajara (O.M.), the Respiratory Department, Institut de Recerca Biomèdica de Lleida, Lleida (F.B.), and Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES), Madrid (F.B.) - all in Spain; Instituto do Coracao (Incor) and Hospital Universitario (L.F.D., G.L.-F.) and the Hypertension Unit, Renal Division, University of São Paulo Medical Sc
authors: Craig S
authors: CS
authors: Anderson
mesh_terms: D000368:Aged; D002318:Cardiovascular Diseases / Q000401:mortality / Q000517:prevention & control; D002561:Cerebrovascular Disorders / Q000150:complications; D045422:Continuous Positive Airway Pressure; D003324:Coronary Artery Disease / Q000150:complications; D005260:Female; D006760:Hospitalization; D006801:Humans; D057194:Intention to Treat Analysis; D008297:Male; D008875:Middle Aged; D020181:Sleep Apnea, Obstructive / Q000209:etiology / Q000628:therapy*; D016896:Treatment Outcome