title: Association of Adiponectin Polymorphism with Metabolic Syndrome Risk and Adiponectin Level with Stroke Risk: A Meta-Analysis.
abstract: Many previous studies have provided evidence that the ADIPOQ +45T>G polymorphism (rs2241766) might cause metabolic syndrome (MS). As a cardiovascular manifestation of MS, the incidence of stroke is associated with adiponectin; however, the results remain controversial and inconsistent. Systematic searches of relevant studies published up to Dec 2014 and Jan 2016 on the ADIPOQ +45T>G polymorphism and the risk of MS and adiponectin levels and the risk of stroke, respectively, were conducted in MEDLINE and EMBASE. The odds ratio (OR) or risk ratio (RR) and their 95% confidence interval (95% CI) were extracted. Sixteen studies containing 4,113 MS cases and 3,637 healthy controls indicated a weak positive association between ADIPOQ +45 T>G and MS in the dominant genetic model (OR = 1.30, 95% CI = 1.03-1.65), which was also validated by stratified subgroup analyses. Twelve studies including 26,213 participants and 4,246 stroke cases indicated that 5 μg/ml increments in adiponectin level were not relevant to stroke risk (RR = 1.05, 95% CI = 1.00-1.10, P = 0.069). This study suggested a weak positive association of ADIPOQ +45T>G with MS and a strong association with metabolic-related disease. Additionally, adiponectin level was not a causal factor of increasing stroke risk.
authors: The Key Laboratory of Geriatrics, Beijing Hospital, National Center of Gerontology &Beijing Institute of Geriatrics, Beijing 100730, P.R. China.
authors: Hui-Ping
authors: HP
authors: Yuan
authors: The Key Laboratory of Geriatrics, Beijing Hospital, National Center of Gerontology &Beijing Institute of Geriatrics, Beijing 100730, P.R. China.
authors: Liang
authors: L
authors: Sun
authors: The Key Laboratory of Geriatrics, Beijing Hospital, National Center of Gerontology &Beijing Institute of Geriatrics, Beijing 100730, P.R. China.
authors: Xing-Hui
authors: XH
authors: Li
authors: The Key Laboratory of Geriatrics, Beijing Hospital, National Center of Gerontology &Beijing Institute of Geriatrics, Beijing 100730, P.R. China.
authors: Fu-Gang
authors: FG
authors: Che
authors: The Key Laboratory of Geriatrics, Beijing Hospital, National Center of Gerontology &Beijing Institute of Geriatrics, Beijing 100730, P.R. China.
authors: Xiao-Quan
authors: XQ
authors: Zhu
authors: The Key Laboratory of Geriatrics, Beijing Hospital, National Center of Gerontology &Beijing Institute of Geriatrics, Beijing 100730, P.R. China.
authors: Fan
authors: F
authors: Yang
authors: The Key Laboratory of Geriatrics, Beijing Hospital, National Center of Gerontology &Beijing Institute of Geriatrics, Beijing 100730, P.R. China.
authors: Jing
authors: J
authors: Han
authors: The Key Laboratory of Geriatrics, Beijing Hospital, National Center of Gerontology &Beijing Institute of Geriatrics, Beijing 100730, P.R. China.
authors: Chun-Yuan
authors: CY
authors: Jia
authors: The Key Laboratory of Geriatrics, Beijing Hospital, National Center of Gerontology &Beijing Institute of Geriatrics, Beijing 100730, P.R. China.
authors: Ze
authors: Z
authors: Yang
mesh_terms: D052242:Adiponectin / Q000097:blood / Q000235:genetics*; D016001:Confidence Intervals; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D008659:Metabolic Diseases / Q000453:epidemiology / Q000235:genetics*; D024821:Metabolic Syndrome / Q000453:epidemiology / Q000235:genetics*; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D012306:Risk; D020521:Stroke / Q000453:epidemiology / Q000235:genetics*
chemical_list: C499918:ADIPOQ protein, human; D052242:Adiponectin