title: How tissue damage MET metabolism: Regulation of the systemic damage response.
abstract: Living organisms experience tissue damage from both, the surrounding environment and from inside their bodies. Tissue repair/regeneration is triggered by local tissue injury to restore an injured, or lost, part of the body. Tissue damage results in a series of responses, not only locally but also systemically in distant tissues. In our recent publication, we established a "dual system" that induces spatiotemporal tissue damage simultaneously with gene manipulation in surrounding tissues. With this system, we demonstrated that appropriate regulation of methionine metabolism in the fat body is required for tissue repair in Drosophila wing discs, thus highlighting the importance of systemic damage response (SDR) in tissue repair. This "Extra View" aims to discuss our recent reports that propose methionine metabolism to be an essential part of SDR, together with related topics in several model organisms.
authors: a Department of Genetics , Graduate School of Pharmaceutical Sciences, The University of Tokyo , Bunkyo-ku, Tokyo , Japan.
authors: Soshiro
authors: S
authors: Kashio
authors: a Department of Genetics , Graduate School of Pharmaceutical Sciences, The University of Tokyo , Bunkyo-ku, Tokyo , Japan.|b The Francis Crick Institute , The Ridgeway, Mill Hill, London , United Kingdom.
authors: Fumiaki
authors: F
authors: Obata
authors: a Department of Genetics , Graduate School of Pharmaceutical Sciences, The University of Tokyo , Bunkyo-ku, Tokyo , Japan.|c Agency for Medical Research and Development-Core Research for Evolutional Medical Science and Technology (AMED-CREST), Japan Agency for Medical Research and Development , Chiyoda-ku, Tokyo , Japan.
authors: Masayuki
authors: M
authors: Miura
mesh_terms: D000818:Animals; D029721:Drosophila Proteins / Q000737:chemistry / Q000378:metabolism*; D004331:Drosophila melanogaster / Q000254:growth & development / Q000378:metabolism*; D005216:Fat Body / Q000378:metabolism*; D018507:Gene Expression Regulation, Developmental; D060227:Imaginal Discs / Q000502:physiology; D008715:Methionine / Q000378:metabolism*; D012038:Regeneration; D014921:Wings, Animal / Q000378:metabolism
chemical_list: D029721:Drosophila Proteins; D008715:Methionine
keywords: Drosophila melanogaster; S-adenosylmethionine; imaginal disc; methionine metabolism; regeneration; systemic damage response; tissue repair