title: Transmission of Drug-Resistant Leprosy in Guinea-Conakry Detected Using Molecular Epidemiological Approaches.
abstract: Molecular drug susceptibility testing was performed on skin biopsies from 24 leprosy patients from Guinea-Conakry for the first time. We identified primary drug resistance in 4 cases and a dapsone-resistant cluster caused by the same strain. Primary transmission of drug-resistant Mycobacterium leprae, including a rifampicin-resistant strain, is reported.
authors: Global Health Institute, Ecole Polytechnique Fédérale de Lausanne, Switzerland.
authors: Charlotte
authors: C
authors: Avanzi
authors: Global Health Institute, Ecole Polytechnique Fédérale de Lausanne, Switzerland.
authors: Philippe
authors: P
authors: Busso
authors: Global Health Institute, Ecole Polytechnique Fédérale de Lausanne, Switzerland.
authors: Andrej
authors: A
authors: Benjak
authors: Global Health Institute, Ecole Polytechnique Fédérale de Lausanne, Switzerland.
authors: Chloé
authors: C
authors: Loiseau
authors: Centre national d'Appui à la lutte contre la Maladie, Bamako, Mali.
authors: Abdoulaye
authors: A
authors: Fomba
authors: Centre national d'Appui à la lutte contre la Maladie, Bamako, Mali.
authors: Glodia
authors: G
authors: Doumbia
authors: Programme National Lèpre de Guinée, Conakry, Guinea.
authors: Idrissa
authors: I
authors: Camara
authors: Programme National Lèpre de Guinée, Conakry, Guinea.
authors: André
authors: A
authors: Lamou
authors: Programme National Lèpre de Guinée, Conakry, Guinea.
authors: Gouressy
authors: G
authors: Sock
authors: Programme National Lèpre de Guinée, Conakry, Guinea.
authors: Tiguidanké
authors: T
authors: Drame
authors: Centre national d'Appui à la lutte contre la Maladie, Bamako, Mali.
authors: Mamadou
authors: M
authors: Kodio
authors: Programme National Lèpre de Guinée, Conakry, Guinea.
authors: Fatoumata
authors: F
authors: Sakho
authors: Centre national d'Appui à la lutte contre la Maladie, Bamako, Mali.
authors: Samba O
authors: SO
authors: Sow
authors: Global Health Institute, Ecole Polytechnique Fédérale de Lausanne, Switzerland.
authors: Stewart T
authors: ST
authors: Cole
authors: Centre InterFacultaire de Formation et de Recherche en Environnement pour le Développement Durable University of Abomey-Calavi, Cotonou, Benin.
authors: Roch Christian
authors: RC
authors: Johnson
mesh_terms: D000904:Antibiotics, Antitubercular / Q000494:pharmacology* / Q000627:therapeutic use; D000995:Antitubercular Agents / Q000494:pharmacology* / Q000627:therapeutic use; D001706:Biopsy; D004269:DNA, Bacterial / Q000235:genetics; D003622:Dapsone / Q000494:pharmacology / Q000627:therapeutic use; D004352:Drug Resistance, Microbial; D005260:Female; D016680:Genome, Bacterial; D016701:Guinea / Q000453:epidemiology; D006801:Humans; D007918:Leprosy / Q000453:epidemiology / Q000382:microbiology* / Q000635:transmission*; D008297:Male; D009166:Mycobacterium leprae / Q000187:drug effects* / Q000235:genetics / Q000302:isolation & purification; D012293:Rifampin / Q000494:pharmacology / Q000627:therapeutic use; D017422:Sequence Analysis, DNA; D012867:Skin / Q000382:microbiology / Q000473:pathology
chemical_list: D000904:Antibiotics, Antitubercular; D000995:Antitubercular Agents; D004269:DNA, Bacterial; D003622:Dapsone; D012293:Rifampin
keywords: Guinea-Conakry; drug resistance; leprosy