title: Diabetic ketosis during hyperglycemic crisis is associated with decreased all-cause mortality in patients with type 2 diabetes mellitus.
abstract: Patients with type 2 diabetes mellitus have impaired ketogenesis due to high serum insulin and low growth hormone levels. Evidence exists that ketone bodies might improve kidney and cardiac function. In theory, improved ketogenesis in diabetics may have positive effects. We aimed to assess the impact of diabetic ketosis on all-cause mortality in patients with type 2 diabetes mellitus presenting with hyperglycemic crisis. We analyzed 486 patients with diabetic ketosis and 486 age and sex-matched patients with non-ketotic hyperglycemia presenting to the emergency department. Cox proportional hazard models were used to analyze the link between patient characteristics and mortality. During an observation time of 33.4 months, death of any cause occurred in 40.9 % of the non-ketotic hyperglycemia group and 30.2 % of the DK group (hazard ratio in the diabetic ketosis group, 0.63; 95 % confidence interval 0.48-0.82; P = 0.0005). Patients with diabetic ketosis had a lower incidence of symptomatic heart failure and had improved renal function. They used less furosemide and antihypertensive drugs, more metformin and lower insulin doses, all of which was independently associated with decreased mortality. Plasma glucose and glycated hemoglobin levels were similar in both groups. Patients with hyperglycemic crisis and diabetic ketosis have decreased all-cause mortality when compared to those with non-ketotic hyperglycemia. diabetic ketosis might be a compensatory mechanism rather than a complication in patients with hyperglycemic crises, but further prospective studies are warranted.
authors: Department of Endocrinology, Diabetes and Metabolic Diseases "Mladen Sekso", University Hospital Center "Sestre Milosrdnice", University of Zagreb School of Medicine, Vinogradska cesta 29, Zagreb, 10000, Croatia. ivkruljac@gmail.com.
authors: Ivan
authors: I
authors: Kruljac
authors: Department of Endocrinology, Diabetes and Metabolic Diseases "Mladen Sekso", University Hospital Center "Sestre Milosrdnice", University of Zagreb School of Medicine, Vinogradska cesta 29, Zagreb, 10000, Croatia.
authors: Miroslav
authors: M
authors: Ćaćić
authors: University of Zagreb School of Medicine, Zagreb, Croatia.
authors: Petra
authors: P
authors: Ćaćić
authors: Department of Internal Medicine, University Hospital "Sveti Duh", Zagreb, Croatia.
authors: Vedran
authors: V
authors: Ostojić
authors: Clinical Institute of Chemistry, University Hospital Center "Sestre Milosrdnice", University of Zagreb Faculty of Pharmacy and Biochemistry, Zagreb, Croatia.
authors: Mario
authors: M
authors: Štefanović
authors: Department of Emergency Medicine, University Hospital Center "Sestre Milosrdnice", Zagreb, Croatia.
authors: Aljoša
authors: A
authors: Šikić
authors: Department of Endocrinology, Diabetes and Metabolic Diseases "Mladen Sekso", University Hospital Center "Sestre Milosrdnice", University of Zagreb School of Medicine, Vinogradska cesta 29, Zagreb, 10000, Croatia.
authors: Milan
authors: M
authors: Vrkljan
mesh_terms: D000368:Aged; D017523:Croatia / Q000453:epidemiology; D003430:Cross-Sectional Studies; D003924:Diabetes Mellitus, Type 2 / Q000150:complications* / Q000401:mortality; D058065:Diabetic Cardiomyopathies / Q000453:epidemiology / Q000401:mortality / Q000503:physiopathology*; D016883:Diabetic Ketoacidosis / Q000209:etiology* / Q000628:therapy; D003928:Diabetic Nephropathies / Q000453:epidemiology / Q000401:mortality / Q000503:physiopathology*; D004636:Emergency Service, Hospital; D006333:Heart Failure / Q000150:complications* / Q000453:epidemiology / Q000401:mortality / Q000503:physiopathology; D006784:Hospitals, Teaching; D006801:Humans; D006943:Hyperglycemia / Q000503:physiopathology*; D015994:Incidence; D007674:Kidney Diseases / Q000150:complications* / Q000453:epidemiology / Q000401:mortality / Q000503:physiopathology; D008875:Middle Aged; D009026:Mortality; D012042:Registries; D012189:Retrospective Studies; D012720:Severity of Illness Index; D016019:Survival Analysis
keywords: Heart failure; Ketogenesis; Ketosis; Kidney disease; Mortality; Type 2 diabetes mellitus