title: Self-Activated Healable Hydrogels with Reversible Temperature Responsiveness.
abstract: The self-healable polymer hydrogel along with reversible temperature responsiveness was prepared through self-catalyzed dynamic acylhydrazone formation and exchange without any additional stimulus or catalyst. The hydrogel was prepared from a copolymer of N-isopropylacrylamide and acylhydrazine P(NIPAM-co-AH) cross-linked by PEO dialdehyde. Besides self-healed under catalysis of acid and aniline, the hydrogel can also self-heal activated by excess of acylhydrazine groups. Without interference of catalyst during the hydrogel formation and self-healing, this kind of hydrogel prepared from biocompatible polymers can be used in more areas including biotechnology and be more persistent. The hydrogel with a large part of the PNIPAM segment also showed temperature responsiveness around body temperature influenced by the variation in group ratio. This self-healable hydrogel has great potential application in areas related to bioscience and biotechnology.
authors: College of Chemistry and Environmental Science, Hebei University , 180 East Wusi Road, Baoding 071002, China.
authors: Ruixue
authors: R
authors: Chang
authors: College of Chemistry and Environmental Science, Hebei University , 180 East Wusi Road, Baoding 071002, China.
authors: Xuemeng
authors: X
authors: Wang
authors: College of Chemistry and Environmental Science, Hebei University , 180 East Wusi Road, Baoding 071002, China.
authors: Xu
authors: X
authors: Li
authors: College of Chemistry and Environmental Science, Hebei University , 180 East Wusi Road, Baoding 071002, China.
authors: Heng
authors: H
authors: An
authors: College of Chemistry and Environmental Science, Hebei University , 180 East Wusi Road, Baoding 071002, China.
authors: Jianglei
authors: J
authors: Qin
keywords: dynamic covalent cross-linking; self-catalysis; self-healable hydrogel; sol−gel transition; thermoresponsive