title: Inflammatory Pattern of the Bronchial Mucosa in Patients with Asthma with Airway Hyperresponsiveness to Hypoosmotic Stimulus.
abstract: Positive reaction of the bronchi to distilled water inhalation in asthmatics is associated with significant stimulation of the respiratory epithelium desquamation against the background of increased content of eosinophilic and neutrophilic leukocytes in induced sputum, predomination of eosinophil and neutrophil cytolysis, and lower activity of myeloperoxidase in leukocyte granules (in comparison with the parameter in patients with a negative response to bronchostimulation). Enhanced cytolysis and destruction of leukocytes and high myeloperoxidase concentration in the extracellular space are essential for the development of bronchial hyperresponsiveness to hypoosmotic stimulus in asthma.
authors: Laboratory of Functional Methods of Studies of the Respiratory System, Far Eastern Center of Respiratory Physiology and Pathology, Blagoveshchensk, Russia.
authors: A B
authors: AB
authors: Pirogov
authors: Laboratory of Functional Methods of Studies of the Respiratory System, Far Eastern Center of Respiratory Physiology and Pathology, Blagoveshchensk, Russia.
authors: A G
authors: AG
authors: Prikhod'ko
authors: Laboratory of Functional Methods of Studies of the Respiratory System, Far Eastern Center of Respiratory Physiology and Pathology, Blagoveshchensk, Russia. jperelman@mail.ru.
authors: Yu M
authors: YM
authors: Perelman
authors: Amur State Medical Academy, Blagoveshchensk, Russia.
authors: S V
authors: SV
authors: Zinovyev
authors: Laboratory of Functional Methods of Studies of the Respiratory System, Far Eastern Center of Respiratory Physiology and Pathology, Blagoveshchensk, Russia.
authors: E Yu
authors: EY
authors: Afanasyeva
authors: Laboratory of Functional Methods of Studies of the Respiratory System, Far Eastern Center of Respiratory Physiology and Pathology, Blagoveshchensk, Russia.
authors: V P
authors: VP
authors: Kolosov
mesh_terms: D000328:Adult; D001249:Asthma / Q000276:immunology* / Q000378:metabolism / Q000503:physiopathology; D001980:Bronchi / Q000276:immunology / Q000503:physiopathology; D016535:Bronchial Hyperreactivity / Q000276:immunology* / Q000378:metabolism / Q000503:physiopathology; D004804:Eosinophils / Q000276:immunology; D005260:Female; D006801:Humans; D007249:Inflammation / Q000276:immunology* / Q000378:metabolism; D008264:Macrophages / Q000276:immunology; D008297:Male; D009504:Neutrophils / Q000276:immunology; D009195:Peroxidase / Q000378:metabolism; D055815:Young Adult
chemical_list: D009195:Peroxidase
keywords: cytolysis; eosinophilic and neutrophilic leukocytes; inflammation; myeloperoxidase; osmotic airway hyperresponsiveness