title: Platelet count is associated with cardiovascular disease, cancer and mortality: A population-based cohort study.
abstract: BACKGROUND
  Platelet count is used to determine bleeding risk and monitoring thrombopoiesis. While abnormal platelet counts are associated with mortality and morbidity, it is unclear whether it also apply to platelet counts within reference range. We investigated the relationship between platelet count (100-450×109/L) and mortality, development of future cardiovascular disease (myocardial infarction, ischaemic stroke, or peripheral vascular disease), venous thromboembolism, bleeding or cancer in the general population.
  
  
  METHODS
  We conducted a register-based cohort study of 21,252 adults (≥20years) from the Danish General Suburban Population Study (GESUS). Laboratory results from GESUS were linked to information from national registers regarding morbidity and death. Cox proportional hazard regression was conducted with adjustment for age, sex, smoking status, haemoglobin, leukocyte count, C-reactive protein and Charlson comorbidity index.
  
  
  RESULTS
  We found a U-shaped relationship between mortality and platelet count. Mortality was significantly increased for platelet count <175×109/L or >300×109/L. When categorizing platelet count using the interval 201-250×109/L as reference group, platelet count 301-450×109/L was associated with mortality, adjusted hazard ratio (HR)=1.42(95% CI 1.06-1.90) and cardiovascular disease, adjusted HR=1.32 (95% CI 1.03-1.69). Platelet count 100-200×109/L was associated with future cancer, adjusted HR=1.28(95% CI 1.05-1.57), but not with future bleeding or venous thromboembolism.
  
  
  CONCLUSIONS
  Platelet count is associated with mortality, future cardiovascular disease, and future cancer.
authors: Department of Clinical Biochemistry and Pharmacology, Odense University Hospital, Denmark. Electronic address: pernille.vinholt@rsyd.dk.
authors: P J
authors: PJ
authors: Vinholt
authors: Department of Clinical Biochemistry, Aarhus University Hospital, Denmark.
authors: A M
authors: AM
authors: Hvas
authors: Department of Haematology, Odense University Hospital, Denmark.
authors: H
authors: H
authors: Frederiksen
authors: Department of Clinical Biochemistry, Amager Hvidovre Hospital, Denmark.
authors: L
authors: L
authors: Bathum
authors: Department of Clinical Biochemistry, Slagelse-Naestved Hospital, Denmark.
authors: M K
authors: MK
authors: Jørgensen
authors: Department of Clinical Biochemistry and Pharmacology, Odense University Hospital, Denmark.
authors: M
authors: M
authors: Nybo
mesh_terms: D000328:Adult; D000368:Aged; D002318:Cardiovascular Diseases / Q000175:diagnosis / Q000453:epidemiology* / Q000401:mortality; D015331:Cohort Studies; D003718:Denmark / Q000453:epidemiology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000175:diagnosis / Q000453:epidemiology* / Q000401:mortality; D010976:Platelet Count; D011379:Prognosis; D016016:Proportional Hazards Models; D012307:Risk Factors
keywords: Cardiovascular diseases; Mortality; Neoplasms; Risk factors; Thrombocytopenia