title: Genetic identification of arsenate reductase and arsenite oxidase in redox transformations carried out by arsenic metabolising prokaryotes - A comprehensive review.
abstract: Arsenic (As) contamination in water is a cause of major concern to human population worldwide, especially in Bangladesh and West Bengal, India. Arsenite (As(III)) and arsenate (As(V)) are the two common forms in which arsenic exists in soil and groundwater, the former being more mobile and toxic. A large number of arsenic metabolising microorganisms play a crucial role in microbial transformation of arsenic between its different states, thus playing a key role in remediation of arsenic contaminated water. This review focuses on advances in biochemical, molecular and genomic developments in the field of arsenic metabolising bacteria - covering recent developments in the understanding of structure of arsenate reductase and arsenite oxidase enzymes, their gene and operon structures and their mechanism of action. The genetic and molecular studies of these microbes and their proteins may lead to evolution of successful strategies for effective implementation of bioremediation programs.
authors: Department of Environmental Science and Engineering, Indian School of Mines, Dhanbad, Jharkhand, 826004, India.
authors: Nisha
authors: N
authors: Kumari
authors: Department of Environmental Science and Engineering, Indian School of Mines, Dhanbad, Jharkhand, 826004, India. Electronic address: jagadevan.s.ese@ismdhanbad.ac.in.
authors: Sheeja
authors: S
authors: Jagadevan
mesh_terms: D053502:Arsenate Reductases / Q000235:genetics* / Q000378:metabolism; D001149:Arsenates / Q000378:metabolism; D001151:Arsenic / Q000378:metabolism*; D018053:Arsenites / Q000378:metabolism; D001419:Bacteria / Q000235:genetics / Q000378:metabolism*; D001426:Bacterial Proteins / Q000235:genetics* / Q000378:metabolism; D001673:Biodegradation, Environmental; D001711:Biotransformation; D004785:Environmental Pollutants / Q000378:metabolism*; D010084:Oxidation-Reduction; D010088:Oxidoreductases / Q000235:genetics* / Q000378:metabolism
chemical_list: D001149:Arsenates; D018053:Arsenites; D001426:Bacterial Proteins; D004785:Environmental Pollutants; D010088:Oxidoreductases; C078179:arsenite oxidase; D053502:Arsenate Reductases; C015001:arsenite; D001151:Arsenic; C025657:arsenic acid
keywords: Arsenate reductase; Arsenic; Arsenite oxidase; Bioremediation; Genes; Operon