title: Comparison of Virtual Touch Tissue Imaging & Quantification (VTIQ) and Virtual Touch Tissue Quantification (VTQ) for diagnosis of thyroid nodules.
abstract: OBJECTIVE
  The aim of this study was to compare the diagnostic performance of Virtual Touch Tissue Imaging & Quantification (VTIQ) and Virtual Touch Tissue Quantification (VTQ) in differentiating benign from malignant thyroid nodules (TNs).
  
  
  METHODS
  In this study 107 TNs in 107 patients were enrolled and analyzed. All of them were detected by conventional ultrasound (US) and confirmed by fine-needle aspiration (FNA) biopsy or surgery. VTIQ and VTQ examinations were performed on each nodule. Thereafter the median and mean of shear wave speed (SWS) values in lesions on VTIQ and VTQ were computed (SWS-median and SWS-mean). With cytological results of FNA and histological results adopted as the reference standard, area under the receiver operating characteristic (AUROC) curve analysis was performed to evaluate the diagnostic efficiency of VTIQ and VTQ in differentiation of TNs.
  
  
  RESULTS
  Among the 107 lesions, 19 were papillary thyroid carcinomas (PTCs), 1 was medullary thyroid carcinoma (MTC) and 87 were benign. In total lesions, AUROC-median in VTIQ was significantly higher than that in VTQ (0.851 vs.0.759; p < 0.05).
  
  
  CONCLUSIONS
  VTIQ and VTQ were equivalent in diagnosing TNs when using SWS-mean, whereas VTIQ showed better performance in comparison with VTQ when using SWS-median.
authors: Department of Ultrasound, Guangdong Medical University Affiliated Hospital, Zhanjiang, China.|Department of Medical Ultrasound, Shanghai Tenth People's Hospital, Ultrasound Research and Education Institute, Tongji University School of Medicine, Shanghai, China.|Thyroid Institute, Tongji University School of Medicine, Shanghai, China.|Shanghai Research Center for Thyroid Diseases, Shanghai, China.
authors: Yu-Ping
authors: YP
authors: Yang
authors: Department of Ultrasound, Guangdong Medical University Affiliated Hospital, Zhanjiang, China.
authors: Xiao-Hong
authors: XH
authors: Xu
authors: Department of Medical Ultrasound, Shanghai Tenth People's Hospital, Ultrasound Research and Education Institute, Tongji University School of Medicine, Shanghai, China.|Thyroid Institute, Tongji University School of Medicine, Shanghai, China.|Shanghai Research Center for Thyroid Diseases, Shanghai, China.
authors: Xiao-Wan
authors: XW
authors: Bo
authors: Department of Medical Ultrasound, Shanghai Tenth People's Hospital, Ultrasound Research and Education Institute, Tongji University School of Medicine, Shanghai, China.|Thyroid Institute, Tongji University School of Medicine, Shanghai, China.|Shanghai Research Center for Thyroid Diseases, Shanghai, China.
authors: Bo-Ji
authors: BJ
authors: Liu
authors: Department of Medical Ultrasound, Shanghai Tenth People's Hospital, Ultrasound Research and Education Institute, Tongji University School of Medicine, Shanghai, China.|Thyroid Institute, Tongji University School of Medicine, Shanghai, China.|Shanghai Research Center for Thyroid Diseases, Shanghai, China.
authors: Le-Hang
authors: LH
authors: Guo
authors: Department of Medical Ultrasound, Shanghai Tenth People's Hospital, Ultrasound Research and Education Institute, Tongji University School of Medicine, Shanghai, China.|Thyroid Institute, Tongji University School of Medicine, Shanghai, China.|Shanghai Research Center for Thyroid Diseases, Shanghai, China.
authors: Jun-Mei
authors: JM
authors: Xu
authors: Department of Medical Ultrasound, Shanghai Tenth People's Hospital, Ultrasound Research and Education Institute, Tongji University School of Medicine, Shanghai, China.|Thyroid Institute, Tongji University School of Medicine, Shanghai, China.|Shanghai Research Center for Thyroid Diseases, Shanghai, China.
authors: Li-Ping
authors: LP
authors: Sun
authors: Department of Medical Ultrasound, Shanghai Tenth People's Hospital, Ultrasound Research and Education Institute, Tongji University School of Medicine, Shanghai, China.|Thyroid Institute, Tongji University School of Medicine, Shanghai, China.|Shanghai Research Center for Thyroid Diseases, Shanghai, China.
authors: Hui-Xiong
authors: HX
authors: Xu
mesh_terms: D000328:Adult; D000368:Aged; D044963:Biopsy, Fine-Needle / Q000379:methods*; D054459:Elasticity Imaging Techniques / Q000379:methods*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D016606:Thyroid Nodule / Q000175:diagnosis* / Q000473:pathology; D014463:Ultrasonography / Q000379:methods*
keywords: Shear wave elastography; diagnostic performance; fine-needle aspiration; thyroid nodules; ultrasound