title: Sensitive and selective electrochemical detection of artemisinin based on its reaction with p-aminophenylboronic acid.
abstract: The electrochemical detection of artemisinin generally requires high oxidation potential or the use of complex electrode modification. We find that artemisinin can react with p-aminophenylboronic acid to produce easily electrochemically detectable aminophenol for the first time. By making use of the new reaction, we report an alternative method to detect artemisinin through the determination of p-aminophenol. The calibration curve for the determination of artemisinin is linear in the range of 2 μmol L(-1) to 200 μmol L(-1) with the detection limit of 0.8 μmol L(-1), which is more sensitive than other reported electrochemical methods. The relative standard deviation is 4.83% for the determination of 10 μM artemisinin. Because the oxidation potential of p-aminophenol is around 0 V, the present method is high selective. When 40 μM, 90 μM and 140 μM of artemisinin were spiked to compound naphthoquine phosphate tablet samples, the recoveries are 107.6%, 105.4% and 101.7%, respectively. This detection strategy is attractive for the detection of artemisinin and its derivatives. The finding that artemisinin can react with aromatic boronic acid has the potential to be exploited for the development of other sensors, such as fluorescence artemisinin sensors.
authors: College of Chemistry and Bioengineering, Guilin University of Technology, Guilin 541004, China; State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin 130022, PR China.
authors: Chao
authors: C
authors: Wang
authors: State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin 130022, PR China; Laboratory of Analytical Optochemotronics, Kharkiv National University of Radio Electronics, 14 Nauka Ave., Kharkiv 61166, Ukraine.
authors: Yuriy T
authors: YT
authors: Zholudov
authors: State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin 130022, PR China; University of the Chinese Academy of Sciences, Chinese Academy of Sciences, No. 19A Yuquanlu, Beijing 100049, China.
authors: Anaclet
authors: A
authors: Nsabimana
authors: College of Chemistry and Bioengineering, Guilin University of Technology, Guilin 541004, China; State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin 130022, PR China. Electronic address: guobaoxu@ciac.ac.cn.
authors: Guobao
authors: G
authors: Xu
authors: College of Chemistry and Bioengineering, Guilin University of Technology, Guilin 541004, China. Electronic address: likianping@glut.edu.cn.
authors: Jianping
authors: J
authors: Li
keywords: Artemisinin; Electrochemical sensor; p-aminophenol; p-aminophenylboronic acid