title: Enhanced Dynamics of Hydrated tRNA on Nanodiamond Surfaces: A Combined Neutron Scattering and MD Simulation Study.
abstract: Nontoxic, biocompatible nanodiamonds (ND) have recently been implemented in rational, systematic design of optimal therapeutic use in nanomedicines. However, hydrophilicity of the ND surface strongly influences structure and dynamics of biomolecules that restrict in situ applications of ND. Therefore, fundamental understanding of the impact of hydrophilic ND surface on biomolecules at the molecular level is essential. For tRNA, we observe an enhancement of dynamical behavior in the presence of ND contrary to generally observed slow motion at strongly interacting interfaces. We took advantage of neutron scattering experiments and computer simulations to demonstrate this atypical faster dynamics of tRNA on ND surface. The strong attractive interactions between ND, tRNA, and water give rise to unlike dynamical behavior and structural changes of tRNA in front of ND compared to without ND. Our new findings may provide new design principles for safer, improved drug delivery platforms.
authors: Department of Physics and Astronomy, Wayne State University , Detroit, Michigan 48201, United States.
authors: Gurpreet K
authors: GK
authors: Dhindsa
authors: Department of Physics and Astronomy, Wayne State University , Detroit, Michigan 48201, United States.
authors: Debsindhu
authors: D
authors: Bhowmik
authors: Center for Nanophase Materials Sciences, Oak Ridge National Laboratory , Oak Ridge, Tennessee 37831, United States.|Computer Science and Mathematics Division, Oak Ridge National Laboratory , Oak Ridge, Tennessee 37831, United States.
authors: Monojoy
authors: M
authors: Goswami
authors: Biology and Soft Matter Division, Oak Ridge National Laboratory , Oak Ridge, Tennessee 37831, United States.
authors: Hugh
authors: H
authors: O'Neill
authors: Chemical and Engineering Materials Division, Oak Ridge National Laboratory , Oak Ridge, Tennessee 37831, United States.
authors: Eugene
authors: E
authors: Mamontov
authors: Center for Nanophase Materials Sciences, Oak Ridge National Laboratory , Oak Ridge, Tennessee 37831, United States.|Computer Science and Mathematics Division, Oak Ridge National Laboratory , Oak Ridge, Tennessee 37831, United States.
authors: Bobby G
authors: BG
authors: Sumpter
authors: Institute of Natural Science & Department of Physics and Astronomy, Shanghai Jiao Tong University , Shanghai 200240, China.
authors: Liang
authors: L
authors: Hong
authors: Center for Nanophase Materials Sciences, Oak Ridge National Laboratory , Oak Ridge, Tennessee 37831, United States.
authors: Panchapakesan
authors: P
authors: Ganesh
authors: Department of Physics and Astronomy, Wayne State University , Detroit, Michigan 48201, United States.
authors: Xiang-Qiang
authors: XQ
authors: Chu