title: Biosensors for breast cancer diagnosis: A review of bioreceptors, biotransducers and signal amplification strategies.
abstract: Breast cancer is highly prevalent in females and accounts for second highest number of deaths, worldwide. Cumbersome, expensive and time consuming detection techniques presently available for detection of breast cancer potentiates the need for development of novel, specific and ultrasensitive devices. Biosensors are the promising and selective detection devices which hold immense potential as point of care (POC) tools. Present review comprehensively scrutinizes various breast cancer biosensors developed so far and their technical evaluation with respect to efficiency and potency of selected bioreceptors and biotransducers. Use of glycoproteins, DNA biomarkers, micro-RNA, circulatory tumor cells (CTC) and some potential biomarkers are introduced briefly. The review also discusses various strategies used in signal amplification such as nanomaterials, redox mediators, p19 protein, duplex specific nucleases (DSN) and redox cycling.
authors: Centre for Environmental Science and Technology, Central University of Punjab, Bathinda, 151001 India. Electronic address: sunil.cevs@gmail.com.
authors: Sunil
authors: S
authors: Mittal
authors: Centre for Environmental Science and Technology, Central University of Punjab, Bathinda, 151001 India. Electronic address: hardeep_kaur007@rediffmail.com.
authors: Hardeep
authors: H
authors: Kaur
authors: Centre for Environmental Science and Technology, Central University of Punjab, Bathinda, 151001 India. Electronic address: ngautam86@gmail.com.
authors: Nandini
authors: N
authors: Gautam
authors: Centre for Animal Sciences, Central University of Punjab, Bathinda, 151001 India. Electronic address: anilmantha@gmail.com.
authors: Anil K
authors: AK
authors: Mantha
mesh_terms: D000818:Animals; D000906:Antibodies / Q000737:chemistry; D052157:Aptamers, Nucleotide / Q000737:chemistry; D014408:Biomarkers, Tumor / Q000032:analysis; D015374:Biosensing Techniques / Q000295:instrumentation / Q000379:methods*; D001940:Breast / Q000473:pathology*; D001943:Breast Neoplasms / Q000175:diagnosis*; D018076:DNA, Complementary / Q000737:chemistry; D005260:Female; D006023:Glycoproteins / Q000032:analysis; D006801:Humans; D035683:MicroRNAs / Q000032:analysis; D009360:Neoplastic Cells, Circulating / Q000473:pathology; D019095:Point-of-Care Systems; D014159:Transducers
chemical_list: D000906:Antibodies; D052157:Aptamers, Nucleotide; D014408:Biomarkers, Tumor; D018076:DNA, Complementary; D006023:Glycoproteins; D035683:MicroRNAs
keywords: Biomarkers; Breast cancer; Nanomaterials; Redox cycling; Redox mediators