title: Activating TCR Signaling to Thwart T-ALL.
abstract: Thymic negative selection is a process that aims to eliminate autoreactive T cells by inducing the apoptosis of thymocytes expressing a T-cell receptor (TCR) with high affinity for self-MHC. In this issue, Trinquand and colleagues demonstrate that TCR engagement or anti-CD3 stimulation of TCR-expressing T acute lymphoblastic leukemia cells results in their apoptosis. This cell death is reminiscent of thymic negative selection and has the potential for therapeutic exploitation. Cancer Discov; 6(9); 946-8. ©2016 AACR.See related article by Trinquand et al., p. 972.
authors: Campbell Family Institute for Breast Cancer Research at the Princess Margaret Cancer Centre, University Health Network, Toronto, Canada.
authors: François
authors: F
authors: Lemonnier
authors: Campbell Family Institute for Breast Cancer Research at the Princess Margaret Cancer Centre, University Health Network, Toronto, Canada. Department of Medical Biophysics, University of Toronto, University Health Network, Toronto, Canada. tmak@uhnresearch.ca.
authors: Tak W
authors: TW
authors: Mak
mesh_terms: D000818:Animals; D017209:Apoptosis; D017252:CD3 Complex / Q000378:metabolism*; D006801:Humans; D051379:Mice; D054218:Precursor T-Cell Lymphoblastic Leukemia-Lymphoma / Q000276:immunology / Q000378:metabolism* / Q000628:therapy; D011948:Receptors, Antigen, T-Cell / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D017252:CD3 Complex; D011948:Receptors, Antigen, T-Cell