title: Neuropathology Associated With Diffuse Excessive High Signal Intensity Abnormalities on Magnetic Resonance Imaging in Very Preterm Infants.
abstract: Diffuse excessive high signal intensity abnormality is the most common finding on term-equivalent age magnetic resonance imaging in extremely preterm infants. Yet its clinical significance remains a matter of debate, in part because of a lack of prior imaging-pathology correlational studies.
  
  
  
  We present two 24-week-gestation infants with complicated clinical courses who died at 33 and 46 weeks postmenstrual age with magnetic resonance imaging evidence of diffuse excessive high signal intensity. Two patients with periventricular leukomalacia and two without injury were examined for comparison. Immunohistochemistry characterized the presence of reactive astrocytes, microglia, myelin, and axons. Infants with periventricular leukomalacia demonstrated the typical microscopic necrosis with spheroids, gliosis/microgliosis with reduction in stainable myelin and axons. Infants with diffuse excessive high signal intensity showed vacuolated regions with increased reactive astrocytes and microglia and fewer oligodendroglial cell bodies/processes and dramatic reduction in axon number.
  
  
  
  These two individuals with diffuse excessive high signal intensity exhibited pathologic characteristics that were overlapping but distinct from those of periventricular leukomalacia.
authors: Cincinnati Children's Hospital, The Perinatal Institute, Cincinnati, Ohio; Department of Pediatrics, Ohio State University College of Medicine, Columbus, Ohio. Electronic address: naparikh7@gmail.com.
authors: Nehal A
authors: NA
authors: Parikh
authors: Department of Pathology and Laboratory Medicine, Nationwide Children's Hospital, Columbus, Ohio; Department of Pathology, Division of Anatomy, The Ohio State University College of Medicine, Columbus, Ohio.
authors: Christopher R
authors: CR
authors: Pierson
authors: Department of Radiology, Nationwide Children's Hospital, Columbus, Ohio.
authors: Jerome A
authors: JA
authors: Rusin
mesh_terms: D017809:Fatal Outcome; D006801:Humans; D062071:Infant, Extremely Premature; D007231:Infant, Newborn; D007969:Leukomalacia, Periventricular / Q000000981:diagnostic imaging* / Q000473:pathology; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D009422:Nervous System Diseases / Q000000981:diagnostic imaging / Q000473:pathology
keywords: magnetic resonance imaging; neuropathology; oligodendrocytes; premature infant; white matter abnormality