title: Non-Coding RNA Molecules Connect Calorie Restriction and Lifespan.
abstract: Calorie restriction (CR) is a broadly effective environmental intervention that extends life by operating through numerous biological processes. Here, we discuss how non-coding RNA (ncRNA) molecules act as mediators and targets of lifespan-extending CR. We also highlight how these RNA molecules connect CR to its effects on genome stability, cell metabolism, programmed cell death, senescence, cancer, and neurodegeneration. We anticipate that an advanced understanding of the connections between CR and non-coding RNA will provide unique insights into aging mechanisms while pointing to novel approaches aimed at modulating aging and age-related diseases.
authors: Department of Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto, 1 King's College Circle, Toronto, Ontario, M5S 1A8, Canada.
authors: Karan J
authors: KJ
authors: Abraham
authors: Department of Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto, 1 King's College Circle, Toronto, Ontario, M5S 1A8, Canada.
authors: Lauren A
authors: LA
authors: Ostrowski
authors: Department of Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto, 1 King's College Circle, Toronto, Ontario, M5S 1A8, Canada; Canada Research Chairs Program, Faculty of Medicine, University of Toronto, 1 King's College Circle, Toronto, Ontario, M5S 1A8, Canada. Electronic address: karim.mekhail@utoronto.ca.
authors: Karim
authors: K
authors: Mekhail
mesh_terms: D000375:Aging / Q000235:genetics*; D000818:Animals; D031204:Caloric Restriction; D042822:Genomic Instability; D006801:Humans; D022661:RNA, Untranslated / Q000235:genetics*
chemical_list: D022661:RNA, Untranslated
keywords: aging; calorie restriction; human disease; non-coding RNA