title: Thiazolobenzyne: a versatile intermediate for multisubstituted benzothiazoles.
abstract: Thiazolobenzyne, which is a benzyne species fused with a thiazole ring, was efficiently generated via an iodine-magnesium exchange reaction of an ortho-iodoaryl triflate-type precursor using a trimethylsilylmethyl Grignard reagent as an activator. A wide range of arynophiles reacted efficiently with the thiazolobenzynes generated by this method to afford various multisubstituted benzothiazoles.
authors: Laboratory of Chemical Bioscience, Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, 2-3-10 Kanda-Surugadai, Chiyoda-ku, Tokyo 101-0062, Japan. thosoya.cb@tmd.ac.jp.
authors: Suguru
authors: S
authors: Yoshida
authors: Takahisa
authors: T
authors: Yano
authors: Yoshitake
authors: Y
authors: Nishiyama
authors: Yoshihiro
authors: Y
authors: Misawa
authors: Masakazu
authors: M
authors: Kondo
authors: Takeshi
authors: T
authors: Matsushita
authors: Kazunobu
authors: K
authors: Igawa
authors: Katsuhiko
authors: K
authors: Tomooka
authors: Takamitsu
authors: T
authors: Hosoya