title: The prevalence of anxiety and depression in patients with or without hyperhidrosis (HH).
abstract: BACKGROUND
  There are conflicting data about the correlation between hyperhidrosis (HH) and anxiety and depression.
  
  
  OBJECTIVE
  We sought to determine the prevalence of anxiety and depression in patients with or without HH.
  
  
  METHODS
  We examined 2017 consecutive dermatology outpatients from Vancouver, British Columbia, Canada, and Shanghai, China, using Patient Health Questionnaire-9 and Generalized Anxiety Disorder-7 scales for anxiety and depression assessments. Multivariable logistic regression analysis was performed to evaluate if the impact of HH on anxiety and depression is dependent on demographic factors and diagnoses of the patients' presenting skin conditions.
  
  
  RESULTS
  The prevalence of anxiety and depression was 21.3% and 27.2% in patients with HH, respectively, and 7.5% and 9.7% in patients without HH, respectively (P value <.001 for both). There were positive correlations between HH severity and the prevalence of anxiety and depression. Multivariable analysis showed that HH-associated increase in anxiety and depression prevalence is independent of demographic factors and presenting skin conditions.
  
  
  CONCLUSIONS
  The data from the questionnaires relied on the accuracy of patients' self-reports.
  
  
  CONCLUSIONS
  Both single variant and multivariable analyses showed a significant association between HH and the prevalence of anxiety and depression in a HH severity-dependent manner.
authors: Hyperhidrosis Clinic, Department of Dermatology and Skin Science, University of British Columbia, Vancouver, British Columbia, Canada.
authors: Rayeheh
authors: R
authors: Bahar
authors: Shanghai Skin Hospital, Tongji University, Shanghai, China.
authors: Pingyu
authors: P
authors: Zhou
authors: Shanghai Skin Hospital, Tongji University, Shanghai, China.
authors: Yudan
authors: Y
authors: Liu
authors: Hyperhidrosis Clinic, Department of Dermatology and Skin Science, University of British Columbia, Vancouver, British Columbia, Canada.
authors: Yuanshen
authors: Y
authors: Huang
authors: Hyperhidrosis Clinic, Department of Dermatology and Skin Science, University of British Columbia, Vancouver, British Columbia, Canada.
authors: Arlie
authors: A
authors: Phillips
authors: Hyperhidrosis Clinic, Department of Dermatology and Skin Science, University of British Columbia, Vancouver, British Columbia, Canada.
authors: Tim K
authors: TK
authors: Lee
authors: Hyperhidrosis Clinic, Department of Dermatology and Skin Science, University of British Columbia, Vancouver, British Columbia, Canada.
authors: Mingwan
authors: M
authors: Su
authors: Department of Dermatology, Anhui Medical University, Hefei, China.
authors: Sen
authors: S
authors: Yang
authors: Hyperhidrosis Clinic, Department of Dermatology and Skin Science, University of British Columbia, Vancouver, British Columbia, Canada.
authors: Sunil
authors: S
authors: Kalia
authors: Department of Dermatology, Anhui Medical University, Hefei, China.
authors: Xuejun
authors: X
authors: Zhang
authors: Hyperhidrosis Clinic, Department of Dermatology and Skin Science, University of British Columbia, Vancouver, British Columbia, Canada. Electronic address: youwen.zhou@ubc.ca.
authors: Youwen
authors: Y
authors: Zhou
mesh_terms: D000328:Adult; D001007:Anxiety / Q000453:epidemiology* / Q000208:ethnology; D001210:Asia, Southeastern / Q000208:ethnology; D001955:British Columbia / Q000453:epidemiology; D002681:China / Q000453:epidemiology; D003863:Depression / Q000453:epidemiology* / Q000208:ethnology; D005260:Female; D006801:Humans; D006945:Hyperhidrosis / Q000523:psychology*; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D011569:Psychiatric Status Rating Scales; D011795:Surveys and Questionnaires; D044465:White People / Q000208:ethnology
keywords: anxiety; depression; dermatology; late-onset hyperhidrosis; multivariable logistic regression analysis; negative impact; primary hyperhidrosis