title: Dimacrolide Sesquiterpene Pyridine Alkaloids from the Stems of Tripterygium regelii.
abstract: Two new dimacrolide sesquiterpene pyridine alkaloids (DMSPAs), dimacroregelines A (1) and B (2), were isolated from the stems of Tripterygium regelii. The structures of both compounds were characterized by extensive 1D and 2D NMR spectroscopic analyses, as well as HRESIMS data. Compounds 1 and 2 are two rare DMSPAs possessing unique 2-(3'-carboxybutyl)-3-furanoic acid units forming the second macrocyclic ring, representing the first example of DMSPAs bearing an extra furan ring in their second macrocyclic ring system. Compound 2 showed inhibitory effects on the proliferation of human rheumatoid arthritis synovial fibroblast cell (MH7A) at a concentration of 20 μM.
authors: State Key Laboratory of Quality Research in Chinese Medicine, Macau Institute for Applied Research in Medicine and Health, Macau University of Science and Technology, Taipa, Macau SAR, China. fandongsheng1985@sina.com.
authors: Dongsheng
authors: D
authors: Fan
authors: State Key Laboratory of Quality Research in Chinese Medicine, Macau Institute for Applied Research in Medicine and Health, Macau University of Science and Technology, Taipa, Macau SAR, China. gyzhu@must.edu.mo.
authors: Guo-Yuan
authors: GY
authors: Zhu
authors: State Key Laboratory of Quality Research in Chinese Medicine, Macau Institute for Applied Research in Medicine and Health, Macau University of Science and Technology, Taipa, Macau SAR, China. tli@must.edu.mo.
authors: Ting
authors: T
authors: Li
authors: State Key Laboratory of Quality Research in Chinese Medicine, Macau Institute for Applied Research in Medicine and Health, Macau University of Science and Technology, Taipa, Macau SAR, China. zhjiang@must.edu.mo.
authors: Zhi-Hong
authors: ZH
authors: Jiang
authors: State Key Laboratory of Quality Research in Chinese Medicine, Macau Institute for Applied Research in Medicine and Health, Macau University of Science and Technology, Taipa, Macau SAR, China. lpbai@must.edu.mo.
authors: Li-Ping
authors: LP
authors: Bai
mesh_terms: D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D001172:Arthritis, Rheumatoid / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D002460:Cell Line; D049109:Cell Proliferation / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D005347:Fibroblasts / Q000378:metabolism / Q000473:pathology; D006801:Humans; D018547:Plant Stems / Q000737:chemistry*; D011725:Pyridines / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D013583:Synovial Membrane / Q000378:metabolism / Q000473:pathology; D029757:Tripterygium / Q000737:chemistry*
chemical_list: D000470:Alkaloids; D000893:Anti-Inflammatory Agents; D011725:Pyridines; D012717:Sesquiterpenes
keywords: Tripterygium regelii; anti-inflammation; dimacrolide sesquiterpene pyridine alkaloids