title: Treatment Outcomes for Malassezia Folliculitis in theDermatology Department of a University Hospital in Japan.
abstract: Topical or systemic antifungal therapy was administered to patients diagnosed with Malassezia folliculitis during the 5-year period between March 2007 and October 2013. The diagnosis of Malassezia folliculitis was established on the basis of characteristic clinical features and direct microscopic findings (10 or more yeast-like fungi per follicle). Treatment consisted of topical application of 2% ketoconazole cream or 100 mg oral itraconazole based on symptom severity and patients' preferences. Treatment was given until papules flattened, and flat papules were examined to determine whether the patient's clinical condition had "improved" and the treatment had been "effective". The subjects were 44 patients (35 men, 9 women), with a mean disease period of 25±15 days. In regard to the lesion site, the frontal portion of the chest was the most common, accounting for 60% of all patients. The mean period required for improvement was 27±16 days in 37 patients receiving the topical antifungal agent and 14±4 days in the 7 patients receiving the systemic antifungal agent. The results were "improved" and the treatment was "effective" in all patients. Neither treatment resulted in any adverse reactions. Although administration of oral agents has been recommended for the treatment of Malassezia folliculitis, this study revealed that beneficial results are safely obtained with topical antifungal therapy alone, similar to those of systemic antifungal agents.
authors: Department of Dermatology, Teikyo University Hospital.
authors: Chikako
authors: C
authors: Suzuki
authors: Midori
authors: M
authors: Hase
authors: Harunari
authors: H
authors: Shimoyama
authors: Yoshihiro
authors: Y
authors: Sei
mesh_terms: D000284:Administration, Oral; D000287:Administration, Topical; D000293:Adolescent; D000328:Adult; D000935:Antifungal Agents / Q000008:administration & dosage*; D003880:Dermatology; D005260:Female; D005499:Folliculitis / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000382:microbiology*; D006748:Hospital Departments; D006785:Hospitals, University; D006801:Humans; D017964:Itraconazole / Q000008:administration & dosage*; D007564:Japan; D007654:Ketoconazole / Q000008:administration & dosage*; D008290:Malassezia; D008297:Male; D008875:Middle Aged; D013997:Time Factors; D014010:Tinea Versicolor; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D000935:Antifungal Agents; D017964:Itraconazole; D007654:Ketoconazole