title: Nonequilibrium Diffusion and Capture Mechanism Ensures Tip Localization of Regulating Proteins on Dynamic Filaments.
abstract: Diffusive motion of regulatory enzymes on biopolymers with eventual capture at a reaction site is a common feature in cell biology. Using a lattice gas model we study the impact of diffusion and capture for a microtubule polymerase and a depolymerase. Our results show that the capture mechanism localizes the proteins and creates large-scale spatial correlations. We develop an analytic approximation that globally accounts for relevant correlations and yields results that are in excellent agreement with experimental data. Our results show that diffusion and capture operates most efficiently at cellular enzyme concentrations which points to in vivo relevance.
authors: Arnold Sommerfeld Center for Theoretical Physics (ASC) and Center for NanoScience (CeNS), Department of Physics, Ludwig-Maximilians-Universität München, Theresienstrasse 37, 80333 München, Germany.
authors: Emanuel
authors: E
authors: Reithmann
authors: Arnold Sommerfeld Center for Theoretical Physics (ASC) and Center for NanoScience (CeNS), Department of Physics, Ludwig-Maximilians-Universität München, Theresienstrasse 37, 80333 München, Germany.
authors: Louis
authors: L
authors: Reese
authors: Arnold Sommerfeld Center for Theoretical Physics (ASC) and Center for NanoScience (CeNS), Department of Physics, Ludwig-Maximilians-Universität München, Theresienstrasse 37, 80333 München, Germany.
authors: Erwin
authors: E
authors: Frey
mesh_terms: D001704:Biopolymers; D003599:Cytoskeleton; D004058:Diffusion; D004798:Enzymes / Q000378:metabolism*; D008870:Microtubules; D009038:Motion; D011506:Proteins
chemical_list: D001704:Biopolymers; D004798:Enzymes; D011506:Proteins