title: Use and Future Investigations of Recombinant and Plasma-Derived Coagulation and Anticoagulant Products in the Neonate.
abstract: Although congenital bleeding disorders can manifest in the newborn period, the most common causes of bleeding and thrombosis in neonates are acquired conditions. Factor concentrates are used for specific diagnoses (hemophilia with inhibitors, specific factor deficiency, von Willebrand disease) and approved indications, and increasingly for off-label indications (bleeding in surgery cardiopulmonary bypass, extracorporeal membrane oxygenation). We will review the approved indications for factor products in the neonate and discuss the evidence and rationale for off-label use of factor products in management of bleeding and thrombosis in the neonate.
authors: BloodCenter of Wisconsin, Milwaukee, WI; Department of Pediatrics, Medical College of Wisconsin, Milwaukee, WI. Electronic address: rowena.punzalan@bcw.edu.
authors: Rowena C
authors: RC
authors: Punzalan
authors: BloodCenter of Wisconsin, Milwaukee, WI; Department of Pathology, Medical College of Wisconsin, Milwaukee, WI.
authors: Jerome L
authors: JL
authors: Gottschall
mesh_terms: D000925:Anticoagulants / Q000627:therapeutic use*; D001777:Blood Coagulation / Q000187:drug effects*; D005169:Factor VIII / Q000627:therapeutic use; D015942:Factor VIIa / Q000627:therapeutic use; D006405:Hematology / Q000379:methods / Q000639:trends; D006467:Hemophilia A / Q000188:drug therapy; D006470:Hemorrhage / Q000188:drug therapy; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D011994:Recombinant Proteins / Q000627:therapeutic use*; D013927:Thrombosis / Q000628:therapy; D014842:von Willebrand Diseases / Q000188:drug therapy
chemical_list: D000925:Anticoagulants; D011994:Recombinant Proteins; D005169:Factor VIII; D015942:Factor VIIa
keywords: Antithrombin concentrate; Factor IX concentrate; Factor VIII concentrate; Factor VIIa; Factor XIII concentrate; Fibrinogen concentrate; Protein C concentrate; Prothrombin complex concentrate; Recombinant factor VIIa concentrate; von Willebrand factor concentrate