title: [Use early morning serum cortisollevel to evaluate the effect of Cushing's disease after transsphenoidal surgery].
abstract: OBJECTIVE
  To predict the therapeutic effect of Cushing's disease after transsphenoidal surgery by using morning serum cortisol level.
  
  
  METHODS
  The clinical data of 275 cases that had transsphenoidal surgery in Peking Union Medical College Hospital from 2010 to 2014 were analyzed retrospectively.Early morning serum cortisol level less than 140 nmol/L 3 days postoperation was usedto predict endocrinological remission. And long-term efficacy was evaluated by follow-up.
  
  
  RESULTS
  Of the 275 patients, there were 49 males and 226 females; average age was 36.5 years old.Remission wasconfirmed in 201 cases, the remission rate was 73.1%, and 8 cases recurrent duringfollow-up.There were 17 macroadenomas, theremission rate was 47.1%; 258 microadenomas and MRI negative adenomas, the remission rate was 74.8%.And 43 recurrent cases had reoperations; the remission rate was 46.5%.
  
  
  CONCLUSIONS
  Early morningserum cortisol 3 days post operation can evaluate the effectof transsphenoidal surgery, but even if the level of cortisol is less than 140 nmol/L, there is still tumor recurrence.Patients should be follow-up for a lifetime.
authors: Peking Union Medical College Hospital, CAMS& PUMC, Beijing 100730, China.
authors: M
authors: M
authors: Feng
authors: L
authors: L
authors: Lu
authors: X J
authors: XJ
authors: Bao
authors: X H
authors: XH
authors: Liu
authors: K
authors: K
authors: Deng
authors: C X
authors: CX
authors: Dai
authors: B
authors: B
authors: Xing
authors: W
authors: W
authors: Lian
authors: J J
authors: JJ
authors: Wei
authors: Y
authors: Y
authors: Yao
authors: H J
authors: HJ
authors: Zhu
authors: R Z
authors: RZ
authors: Wang
mesh_terms: D000236:Adenoma; D000328:Adult; D004704:Endocrinology; D005260:Female; D006761:Hospitals; D006801:Humans; D006854:Hydrocortisone; D008279:Magnetic Resonance Imaging; D008297:Male; D047748:Pituitary ACTH Hypersecretion; D011184:Postoperative Period; D012086:Reoperation; D012189:Retrospective Studies
chemical_list: D006854:Hydrocortisone