title: Polycystic Ovary Syndrome and Increased Soluble Tumor Necrosis Factor Like Weak Inducer of Apoptosis Levels Are Independent Predictors of Dyslipidemia in Youth.
abstract: OBJECTIVE
  Dyslipidemia is common in women with polycystic ovary syndrome (PCOS) irrespective of age. Our aim was to investigate soluble tumor necrosis factor like weak inducer of apoptosis (sTWEAK), a cardiovascular risk marker in PCOS, and to determine if it is associated with dyslipidemia in youth.
  
  
  METHODS
  A prospective-observational study was carried out including 35 PCOS patients and 35 healthy controls. Serum sTWEAK levels were measured using commercially available kits. Multiple logistic regression analysis was then performed to verify the statistically significant differences in the possible predictors of dyslipidemia.
  
  
  RESULTS
  Serum sTWEAK levels and the percentage of women with dyslipidemia were significantly higher in the PCOS group (p = 0.024 and p < 0.001, respectively). Participants were further divided into 2 subgroups based on the presence of dyslipidemia. The percentage of women with PCOS was significantly higher in the dyslipidemic group when compared with controls; 70.7 vs. 20.7%, respectively (p < 0.001). Multiple logistic regression analysis revealed that both the presence of PCOS (OR 7.924, 95% CI 2.117-29.657, p = 0.002) and increased levels of sTWEAK (>693 pg/ml; OR 3.810, 95% CI 1.075-13.501, p = 0.038) were independently associated with dyslipidemia.
  
  
  CONCLUSIONS
  Increased levels of both sTWEAK and PCOS were found to be independently associated with dyslipidemia in youth.
authors: Department of Obstetrics and Gynecology, Zekai Tahir Burak Women's Health Education and Research Hospital, Ankara, Turkey.
authors: Kudret
authors: K
authors: Erkenekli
authors: Efser
authors: E
authors: Oztas
authors: Elif
authors: E
authors: Kuscu
authors: Uğur
authors: U
authors: Keskin
authors: Yasemin Gulcan
authors: YG
authors: Kurt
authors: Ahmet
authors: A
authors: Tas
authors: Nafiye
authors: N
authors: Yilmaz
mesh_terms: D000293:Adolescent; D000328:Adult; D015897:Comorbidity; D000074049:Cytokine TWEAK; D050171:Dyslipidemias / Q000097:blood* / Q000453:epidemiology; D005260:Female; D006801:Humans; D011085:Polycystic Ovary Syndrome / Q000097:blood* / Q000453:epidemiology; D011446:Prospective Studies; D048069:Tumor Necrosis Factors / Q000097:blood*; D055815:Young Adult
chemical_list: D000074049:Cytokine TWEAK; C109743:TNFSF12 protein, human; D048069:Tumor Necrosis Factors