title: Gadolinium toxicity: Iron and ferroportin as central targets.
abstract: Gadolinium-based magnetic resonance (MR) contrast agents (GBCM) causes a devastating systemic fibrosing illness, nephrogenic systemic fibrosis (NSF), in patients with reduced kidney function. GBCM targets iron-recycling CD163- and ferroportin-expressing macrophages to release labile iron that mediates gadolinium toxicity and NSF. GBCA might similarly target iron-rich, ferroportin-expressing structures such as globus pallidus and cerebellar dentate nucleus in the brain to result in metal accumulation and potential toxicity.
authors: Division of Nephrology & Center for Immunity, Inflammation and Regeneration, University of Virginia, Charlottesville, VA. Electronic address: swami@virginia.edu.
authors: Sundararaman
authors: S
authors: Swaminathan
mesh_terms: D000818:Animals; D001921:Brain / Q000187:drug effects*; D027682:Cation Transport Proteins / Q000187:drug effects* / Q000378:metabolism; D003287:Contrast Media / Q000633:toxicity*; D005682:Gadolinium / Q000633:toxicity*; D006801:Humans; D007501:Iron / Q000378:metabolism*; D008279:Magnetic Resonance Imaging; D051379:Mice; D054989:Nephrogenic Fibrosing Dermopathy / Q000378:metabolism*; D012307:Risk Factors; D000098742:Ferroportin
chemical_list: D027682:Cation Transport Proteins; D003287:Contrast Media; D000098742:Ferroportin; D005682:Gadolinium; D007501:Iron
keywords: Brain; Ferroportin; Gadolinium; Iron; Macrophage; Toxicity