title: Hydrogen Sulfide and Inflammatory Joint Diseases.
abstract: BACKGROUND
  Rheumatoid arthritis (RA) and osteoarthritis (OA) are widespread rheumatic diseases characterized by persistent inflammation and joint destruction. Hydrogen sulfide (H2S) is an endogenous gas with important physiologic functions in the brain, vasculature and other organs. Recent studies have found H2S to be a mediator in inflammatory joint diseases.
  
  
  OBJECTIVE
  This review summarizes the recent literature in this area highlighting relevant developments.
  
  
  CONCLUSIONS
  Several authors have found that H2S exhibited anti-inflammatory, anti-catabolic and/or anti-oxidant effects in rodent models of acute arthritis and in in vitro models using human synoviocytes and articular chondrocytes from RA and OA tissues. The earliest studies used fast-dissolving salts, such as NaSH, but GYY4137, which produces H2S more physiologically, shortly appeared. More recently still, new H2S-forming compounds that target mitochondria have been synthesized. These compounds open exciting opportunities for investigating the role of H2S in cell bioenergetics, typically altered in arthritides. Positive results have also been obtained when H2S is administered as a sulphurous water bath, an option meriting further study. These findings suggest that exogenous supplementation of H2S may provide a viable therapeutic option for these diseases, particularly in OA.
authors: CIBER de Bioingenieria, Biomateriales y Nanomedicina (CIBER-BBN), Spain.|Grupo de Reumatologia, Instituto de Investigacion Biomedica (INIBIC), Complexo Hospitalario Universitario A Coruna (CHUAC), Sergas, Universidad de A Coruna (UDC), A Coruna, Spain.
authors: Elena F
authors: EF
authors: Burguera
authors: Grupo de Terapia Celular e Ingenieria Tisular, Departamento de Medicina, Instituto de Investigacion Biomedica (INIBIC), Complexo Hospitalario Universitario A Coruna (CHUAC), Sergas, Universidad de A Coruna (UDC), A Coruna, Spain.
authors: Rosa
authors: R
authors: Meijide-Failde
authors: CIBER de Bioingenieria, Biomateriales y Nanomedicina (CIBER-BBN), Spain.|Grupo de Reumatologia, Instituto de Investigacion Biomedica (INIBIC), Complexo Hospitalario Universitario A Coruna (CHUAC), Sergas, Universidad de A Coruna (UDC), A Coruna, Spain.
authors: Francisco J
authors: FJ
authors: Blanco
mesh_terms: D000818:Animals; D001172:Arthritis, Rheumatoid / Q000188:drug therapy* / Q000378:metabolism; D002478:Cells, Cultured; D002986:Clinical Trials as Topic; D004195:Disease Models, Animal; D006801:Humans; D006862:Hydrogen Sulfide / Q000378:metabolism*; D009025:Morpholines / Q000627:therapeutic use*; D009946:Organothiophosphorus Compounds / Q000627:therapeutic use*; D010003:Osteoarthritis / Q000188:drug therapy* / Q000378:metabolism; D013440:Sulfides / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: C529376:GYY 4137; D009025:Morpholines; D009946:Organothiophosphorus Compounds; D013440:Sulfides; C025451:sodium bisulfide; D006862:Hydrogen Sulfide
keywords: Inflammatory joint diseases; hydrogen sulfide; mitochondria; osteoarthritis; rheumatoid arthritis; sulphurous spring
  waters