title: Successful prediction of cardiovascular risk by new non-invasive vascular indexes using suprasystolic cuff oscillometric waveform analysis.
abstract: Recently, new non-invasive vascular indexes named arterial velocity pulse index (AVI) and arterial pressure volume index (API), which is evaluated by a multifunctional blood pressure monitoring device, were developed using cuff oscillometric technologies and suprasystolic cuff oscillometric wave measurement. However, although a few studies including a computational model have been performed, data on subjects with cardiovascular diseases in actual outpatient clinics remain scant.
  
  
  
  We examined a total 252 consecutive outpatients and analyzed two vascular indexes with various clinical parameters to explore potential utilities of these two indexes in actual clinical settings.
  
  
  
  Although we found that two indexes were correlated with each other, the clinical implications of these indexes seemed to differ. Our analyses showed that AVI significantly correlated with augmentation index, but not with flow-mediated dilatation, and multivariate analyses suggested that enhanced AVI represents increased workload on the heart with elevated central blood pressure. In contrast, although the results of analyses performed to identify clinical parameters independently related to API were obscure and non-specific, after adjustment for multiple clinical variables, API was found to be significantly and independently associated with both Framingham Cardiovascular Risk Score and the Suita Score, suggesting that API is a useful predictor of future cardiovascular events.
  
  
  
  These two new vascular indexes might be useful in actual clinical settings to evaluate cardiovascular risks with various clinical backgrounds.
authors: Yokohama City University Graduate School of Medicine, Department of Medical Science and Cardiorenal Medicine, Yokohama, Japan; Yokohama City University Hospital, Department of Cardiology, Yokohama, Japan.
authors: Rie
authors: R
authors: Sasaki-Nakashima
authors: Yokohama City University Graduate School of Medicine, Department of Medical Science and Cardiorenal Medicine, Yokohama, Japan; Yokohama City University Hospital, Department of Cardiology, Yokohama, Japan.
authors: Tabito
authors: T
authors: Kino
authors: Yokohama City University Graduate School of Medicine, Department of Medical Science and Cardiorenal Medicine, Yokohama, Japan; Yokohama City University Hospital, Department of Cardiology, Yokohama, Japan.
authors: Lin
authors: L
authors: Chen
authors: Yokohama City University Graduate School of Medicine, Department of Medical Science and Cardiorenal Medicine, Yokohama, Japan; Yokohama City University Hospital, Department of Cardiology, Yokohama, Japan.
authors: Hiroshi
authors: H
authors: Doi
authors: Yokohama City University Graduate School of Medicine, Department of Medical Science and Cardiorenal Medicine, Yokohama, Japan; Yokohama City University Hospital, Department of Cardiology, Yokohama, Japan.
authors: Shintaro
authors: S
authors: Minegishi
authors: Yokohama City University Graduate School of Medicine, Department of Medical Science and Cardiorenal Medicine, Yokohama, Japan; Yokohama City University Hospital, Department of Cardiology, Yokohama, Japan.
authors: Kaito
authors: K
authors: Abe
authors: Yokohama City University Graduate School of Medicine, Department of Medical Science and Cardiorenal Medicine, Yokohama, Japan; Yokohama City University Hospital, Department of Cardiology, Yokohama, Japan.
authors: Teruyasu
authors: T
authors: Sugano
authors: Department of Biostatistics, Yokohama City University School of Medicine, Yokohama, Japan.
authors: Masataka
authors: M
authors: Taguri
authors: Yokohama City University Graduate School of Medicine, Department of Medical Science and Cardiorenal Medicine, Yokohama, Japan; Yokohama City University Hospital, Department of Cardiology, Yokohama, Japan. Electronic address: tommmish@yokohama-cu.ac.jp.
authors: Tomoaki
authors: T
authors: Ishigami
mesh_terms: D062186:Arterial Pressure; D001795:Blood Pressure Determination / Q000379:methods*; D002318:Cardiovascular Diseases / Q000209:etiology*; D003430:Cross-Sectional Studies; D005260:Female; D006305:Health Status Indicators; D006801:Humans; D008297:Male; D008875:Middle Aged; D009991:Oscillometry / Q000379:methods*; D011237:Predictive Value of Tests; D063177:Pulse Wave Analysis / Q000379:methods*; D012189:Retrospective Studies; D012307:Risk Factors
keywords: Arterial stiffness; Biomarker; Cuff oscillometric