title: Paired Studies Comparing Clinical Profiles of Lewy Body Dementia with Alzheimer's and Parkinson's Diseases.
abstract: Limited data compares clinical profiles of Lewy Body Dementia (LBD) with Alzheimer's disease (AD) and Parkinson's disease (PD). Twenty-one mildly demented ambulatory LBD subjects were individually matched by MMSE score with 21 AD subjects and by UPDRS motor score with 21 PD subjects. Matched by age, gender, education, and race, pairs were compared using cognitive, functional, behavioral, and motor measures. LBD group performed worse than PD on axial motor, gait, and balance measures. AD had more amnesia and orientation impairments, but less executive and visuospatial deficits than LBD subjects. LBD group had more sleepiness, cognitive/behavioral fluctuations, hallucinations, and sleep apnea than AD or PD. Axial motor, gait, and balance disturbances correlated with executive, visuospatial, and global cognition deficits. LBD is differentiated from AD and PD by retrieval memory, visuospatial, and executive deficits; axial motor, gait and balance impairments; sleepiness, cognitive/behavioral fluctuations, hallucinations, and sleep apnea.
authors: Department of Neurology, The Ohio State University, Columbus, OH, USA.
authors: Douglas W
authors: DW
authors: Scharre
authors: Department of Neurology, The Ohio State University, Columbus, OH, USA.
authors: Shu-Ing
authors: SI
authors: Chang
authors: Division of Biostatistics, College of Public Health, The Ohio State University, Columbus, OH, USA.
authors: Haikady N
authors: HN
authors: Nagaraja
authors: Department of Neurology, The Ohio State University, Columbus, OH, USA.
authors: Ariane
authors: A
authors: Park
authors: Department of Neurology, The Ohio State University, Columbus, OH, USA.
authors: Anahita
authors: A
authors: Adeli
authors: Department of Neurology, The Ohio State University, Columbus, OH, USA.
authors: Punit
authors: P
authors: Agrawal
authors: Physical Therapy Division, School of Health and Rehabilitation Sciences, The Ohio State University, Columbus, OH, USA.
authors: Anne
authors: A
authors: Kloos
authors: Physical Therapy Division, School of Health and Rehabilitation Sciences, The Ohio State University, Columbus, OH, USA.
authors: Deb
authors: D
authors: Kegelmeyer
authors: Department of Neurology, The Ohio State University, Columbus, OH, USA.
authors: Shannon
authors: S
authors: Linder
authors: Physical Therapy Division, School of Health and Rehabilitation Sciences, The Ohio State University, Columbus, OH, USA.
authors: Nora
authors: N
authors: Fritz
authors: Department of Neurology, The Ohio State University, Columbus, OH, USA.
authors: Sandra K
authors: SK
authors: Kostyk
authors: Department of Neurology, The Ohio State University, Columbus, OH, USA.
authors: Maria
authors: M
authors: Kataki
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000175:diagnosis* / Q000503:physiopathology / Q000523:psychology*; D003430:Cross-Sectional Studies; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D020961:Lewy Body Disease / Q000175:diagnosis* / Q000503:physiopathology / Q000523:psychology*; D008297:Male; D008568:Memory / Q000502:physiology; D008875:Middle Aged; D009048:Motor Skills / Q000502:physiology; D009483:Neuropsychological Tests; D010300:Parkinson Disease / Q000175:diagnosis* / Q000503:physiopathology / Q000523:psychology*
keywords: Alzheimer’s disease; Lewy body dementia; Parkinson disease; Parkinsonian disorders; dementia