title: Efficacy of Kaempferia parviflora in a mouse model of obesity-induced dermatopathy.
abstract: Obesity results from excessive energy intake and physical inactivity, and predisposes one to various diseases. One of these reasons is that enlargement of adipocytes raises the lipid metabolic abnormalities that affect various organs. The skin is one such organ, and it has been reported that subcutaneous adipocyte cells secrete various factors and these factors are involved in reduction of dermal collagen fibers and fragility of the skin in obesity. The present study explored the efficacy of Kaempferia parviflora (KP) in preventing obesity-induced dermatopathy. We used Tsumura Suzuki obese diabetes (TSOD) mice as an obesity model. TSOD mice were fed a standard diet (MF) mixed with either an ethanol extract from KP (KPE), polymethoxyflavonoid-rich extract from KP (PMF), or polymethoxyflavonoid-poor extract from KP (X). We then evaluated the effect of these three KP fractions on aging-like skin damage induced by UVB irradiation. KPE and PMF caused a significant decrease of mouse body weight, and suppressed the increase in the thickness of the subcutaneous fat layer. In addition, KPE shifted the frequency of subcutaneous adipocyte sizes towards smaller cells possibly via its polypharmacological actions. Scanning electron microscopy revealed that the stereostructure of the collagenous fibers in the dermis was better retained in the KPE and PMF groups, in that order. These results offer the first evidence that KPE can attenuate obesity-induced dermatopathy more effectively than PMF, suggesting that KPE (or KP) might be a candidate supplement for preventing obesity-related skin disorders.
authors: Department of Biological Science and Nursing, School of Medicine, Yokohama City University, 3-9 Fukuura, Kanazawa-ku, Yokohama, Kanagawa, 236-0004, Japan.
authors: Moeko
authors: M
authors: Hidaka
authors: Department of Biological Science and Nursing, School of Medicine, Yokohama City University, 3-9 Fukuura, Kanazawa-ku, Yokohama, Kanagawa, 236-0004, Japan.
authors: Kazumasa
authors: K
authors: Horikawa
authors: Department of Biological Science and Nursing, School of Medicine, Yokohama City University, 3-9 Fukuura, Kanazawa-ku, Yokohama, Kanagawa, 236-0004, Japan. akase@yokohama-cu.ac.jp.
authors: Tomoko
authors: http://orcid.org/0000-0002-4768-2999
authors: T
authors: Akase
authors: Department of Biological Science and Nursing, School of Medicine, Yokohama City University, 3-9 Fukuura, Kanazawa-ku, Yokohama, Kanagawa, 236-0004, Japan.|Department of Molecular Pharmacology and Neurobiology, Graduate School of Medicine, Yokohama City University, 3-9 Fukuura, Kanazawa-ku, Yokohama, Kanagawa, 236-0004, Japan.
authors: Hiroko
authors: H
authors: Makihara
authors: Research and Development Division, Toyo Shinyaku Co., Ltd.,, 7-28 Yayoigaoka, Tosu, Saga, 841-0005, Japan.
authors: Takatoshi
authors: T
authors: Ogami
authors: Research and Development Division, Toyo Shinyaku Co., Ltd.,, 7-28 Yayoigaoka, Tosu, Saga, 841-0005, Japan.
authors: Hiroshi
authors: H
authors: Tomozawa
authors: Research and Development Division, Toyo Shinyaku Co., Ltd.,, 7-28 Yayoigaoka, Tosu, Saga, 841-0005, Japan.
authors: Masahito
authors: M
authors: Tsubata
authors: Department of Biological Science and Nursing, School of Medicine, Yokohama City University, 3-9 Fukuura, Kanazawa-ku, Yokohama, Kanagawa, 236-0004, Japan.
authors: Ai
authors: A
authors: Ibuki
authors: Department of Biological Science and Nursing, School of Medicine, Yokohama City University, 3-9 Fukuura, Kanazawa-ku, Yokohama, Kanagawa, 236-0004, Japan.
authors: Yutaka
authors: Y
authors: Matsumoto
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D008297:Male; D051379:Mice; D008820:Mice, Obese; D009765:Obesity / Q000150:complications*; D010936:Plant Extracts / Q000494:pharmacology*; D060888:Real-Time Polymerase Chain Reaction / Q000379:methods*; D012875:Skin Diseases, Metabolic / Q000188:drug therapy* / Q000209:etiology; D030521:Zingiberaceae / Q000737:chemistry*
chemical_list: D010936:Plant Extracts
keywords: Dermis; Kaempferia parviflora; Obesity; Skin disorder; Subcutaneous fat