title: [Use of intravenous immunoglobulin in pregnancy. Report of a patient with common variable immunodeficiency].
abstract: Common variable immunodeficiency is the most commonly-diagnosed primary immunodeficiency in adults; it is characterized by recurrent sinopulmonary and gastrointestinal infections, and increased incidence of malignancy and autoimmune processes. Many patients begin to have clinical manifestations during reproductive age.
  
  
  
  A 34-year-old woman with 12 weeks of gestation who was diagnosed with common variable immunodeficiency after recurrent episodes of rhinosinusitis, pharyngoamygdalitis, and pneumonia. 0.6 g/kg of IVIG was prescribed every 21 days during the second trimester; the patient only presented one episode of pharyngoamygdalitis, with adequate response to treatment with antibiotics. During the third trimester the dose was adjusted to every 14 days. The patient ended the pregnancy at term without complications, with a child without defects and with proper weight and size.
  
  
  
  The administration of immunoglobulin is the main treatment to control common variable immunodeficiency. While the recommended starting dose is 400-800 mg/kg intravenously every 3 to 4 weeks, there is no consensus on the dose to be used in pregnant women. The recommendation is to perform serum level controls before infusion to determine and adjust it.
authors: Instituto Mexicano del Seguro Social, Centro Médico Nacional Siglo XXI, Hospital de Especialidades, Servicio de Alergia e Inmunología Clínica, Ciudad de México, México. jcesar_963@hotmail.com.
authors: Julio César
authors: JC
authors: Cambray-Gutiérrez
authors: Ulises Noel
authors: UN
authors: García-Ramírez
authors: Leonel Gerardo
authors: LG
authors: Del Rivero-Hernández
authors: Patricia
authors: P
authors: López-Pérez
authors: Aurora
authors: A
authors: Chávez-García
mesh_terms: D000328:Adult; D017074:Common Variable Immunodeficiency / Q000628:therapy*; D005260:Female; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000008:administration & dosage*; D007155:Immunologic Factors / Q000008:administration & dosage*; D010612:Pharyngitis / Q000188:drug therapy; D011014:Pneumonia / Q000188:drug therapy; D011247:Pregnancy; D011248:Pregnancy Complications / Q000628:therapy*; D014069:Tonsillitis / Q000188:drug therapy
chemical_list: D016756:Immunoglobulins, Intravenous; D007155:Immunologic Factors
keywords: Common variable immunodeficiency; Human immunoglobulin; Pregnancy