title: Segmentectomy versus wedge resection for the treatment of high-risk operable patients with stage I non-small cell lung cancer: a meta-analysis.
abstract: Although lobectomy is still the preferred treatment for patients with stage I non-small cell lung cancer (NSCLC), segmentectomy or wedge resection is frequently performed on patients who cannot withstand the physiological rigors of lobectomy. The objective of this study was to compare the overall survival (OS), cancer-specific survival (CSS), and disease-free survival outcomes among patients with stage I NSCLC who have undergone these procedures.
  
  
  
  A systematic electronic search in three online databases was conducted from their earliest publication dates to June 2015. The studies were evaluated according to rigorous, predefined inclusion criteria. The hazard ratio (HR) was used as the outcome measure for data combining.
  
  
  
  There were nine eligible studies. These studies included 1181 patients who underwent segmentectomy and 2003 patients who underwent wedge resection. Stage I NSCLC patients who underwent segmentectomy had significantly better OS (HR 0.80; 95% confidence interval [CI], 0.68-0.93; p = 0.004) and CSS (HR 0.42; 95% CI, 0.20-0.88; p = 0.02) rates than those who underwent wedge resection. However, there were no significant differences in OS (HR 0.39; 95% CI, 0.15-1.02; p = 0.06) and CSS (HR 1.87; 95% CI, 0.29-12.06; p = 0.51) rates between segmentectomy and wedge resection in patients with stage Ia NSCLC with tumor size ⩽ 2 cm.
  
  
  
  For patients with stage I NSCLC, segmentectomy results in higher survival rates than wedge resection, whereas the outcomes of wedge resection are comparable to those of segmentectomy for patients with stage Ia NSCLC with tumor size ⩽ 2 cm. Considering the limitations and heterogeneity of the included studies, this conclusion should be further confirmed by rigorous randomized clinical trials.
authors: Department of Thoracic Surgery, Xinqiao Hospital, Third Military Medical University, Chongqing China.
authors: Bing
authors: B
authors: Hou
authors: Department of Thoracic Surgery, Xinqiao Hospital, Third Military Medical University, Chongqing China.
authors: Xu-Feng
authors: XF
authors: Deng
authors: Department of Thoracic Surgery, Xinqiao Hospital, Third Military Medical University, Chongqing China.
authors: Dong
authors: D
authors: Zhou
authors: Xinqiao Hospital, Third Military Medical University, Chongqing 400037, China.
authors: Quan-Xing
authors: QX
authors: Liu
authors: Xinqiao Hospital, Third Military Medical University, Chongqing 400037, China quanxing9999@qq.com 691057831@qq.com.
authors: Ji-Gang
authors: JG
authors: Dai
mesh_terms: D002289:Carcinoma, Non-Small-Cell Lung / Q000473:pathology / Q000601:surgery*; D018572:Disease-Free Survival; D006801:Humans; D008175:Lung Neoplasms / Q000473:pathology / Q000601:surgery*; D009367:Neoplasm Staging; D011013:Pneumonectomy / Q000379:methods*; D015996:Survival Rate
keywords: non-small cell lung cancer; segmentectomy; stage I; wedge resection