title: Bioavailability of the Phenolic Antioxidant 4-Methyl-2,6-Diisobornylphenol After Oral Administration.
abstract: We compared bioavailability of 4-methyl-2,6-diisobornylphenol after single intragastric administration to rats in a dose of 200 mg/kg in starch suspension and in almond oil. Absorption of 4-methyl-2,6-diisobornylphenol in the gastrointestinal tract after administration in almond oil was much more efficient than after administration in aqueous starch mucus.
authors: Laboratory of Pharmacology of Blood Circulation, Tomsk, Russia.
authors: G A
authors: GA
authors: Chernysheva
authors: Laboratory of Pharmacology of Blood Circulation, Tomsk, Russia.
authors: V I
authors: VI
authors: Smolyakova
authors: Laboratory of Physiology, Molecular and Clinical Pharmacology, E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia. elena.yanovskaya@pharmso.ru.
authors: E A
authors: EA
authors: Yanovskaya
authors: Laboratory of Organic Synthesis and Chemistry of Natural Compounds, Institute of Chemistry, Komi Research Center, Ural Division of the Russian Academy of Sciences, Syktyvkar, Komi Republic, Russia.
authors: A V
authors: AV
authors: Kutchin
authors: Laboratory of Organic Synthesis and Chemistry of Natural Compounds, Institute of Chemistry, Komi Research Center, Ural Division of the Russian Academy of Sciences, Syktyvkar, Komi Republic, Russia.
authors: I Yu
authors: IY
authors: Chukicheva
authors: Laboratory of Physiology, Molecular and Clinical Pharmacology, E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia.
authors: V V
authors: VV
authors: Udut
authors: Laboratory of Pharmacology of Blood Circulation, Tomsk, Russia.
authors: M B
authors: MB
authors: Plotnikov
mesh_terms: D000284:Administration, Oral; D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage* / Q000493:pharmacokinetics*; D001892:Camphanes / Q000008:administration & dosage* / Q000493:pharmacokinetics*; D003408:Cresols / Q000008:administration & dosage* / Q000493:pharmacokinetics*; D041981:Gastrointestinal Tract / Q000378:metabolism; D007408:Intestinal Absorption / Q000187:drug effects; D008297:Male; D010636:Phenols / Q000008:administration & dosage* / Q000493:pharmacokinetics*; D010938:Plant Oils / Q000737:chemistry; D051381:Rats; D017208:Rats, Wistar
chemical_list: C533990:4-methyl-2,6-diisobornylphenol; D000975:Antioxidants; D001892:Camphanes; D003408:Cresols; D010636:Phenols; D010938:Plant Oils; C068582:almond oil
keywords: 4-methyl-2,6-diisobornylphenol; absorption; bioavailability