title: Nanomedicine in the application of uveal melanoma.
abstract: Rapid advances in nanomedicine have significantly changed many aspects of nanoparticle application to the eye including areas of diagnosis, imaging and more importantly drug delivery. The nanoparticle-based drug delivery systems has provided a solution to various drug solubility-related problems in ophthalmology treatment. Nanostructured compounds could be used to achieve local ocular delivery with minimal unwanted systematic side effects produced by taking advantage of the phagocyte system. In addition, the in vivo control release by nanomaterials encapsulated drugs provides prolong exposure of the compound in the body. Furthermore, certain nanoparticles can overcome important body barriers including the blood-retinal barrier as well as the corneal-retinal barrier of the eye for effective delivery of the drug. In summary, the nanotechnology based drug delivery system may serve as an important tool for uveal melanoma treatment.
authors: Department of Endocrinology, the Second Xiangya Hospital, Central South University, Changsha 410011, Hunan Province, China; Winship Cancer Institute, School of Medicine, Emory University, Atlanta, Georgia 30322, USA.
authors: Shuo
authors: S
authors: You
authors: Department of Ophthalmology, the Second Xiangya Hospital, Central South University, Changsha 410011, Hunan Province, China.
authors: Jing
authors: J
authors: Luo
authors: Winship Cancer Institute, School of Medicine, Emory University, Atlanta, Georgia 30322, USA; Department of Ophthalmology, School of Medicine, Emory University, Atlanta, Georgia 30322, USA; Department of Pathology, School of Medicine, Emory University, Atlanta, Georgia 30322, USA.
authors: Hans E
authors: HE
authors: Grossniklaus
authors: State Key Laboratory of Biotherapy, Sichuan University, Chengdu 610041, Sichuan Province, China.
authors: Ma-Ling
authors: ML
authors: Gou
authors: State Key Laboratory of Biotherapy, Sichuan University, Chengdu 610041, Sichuan Province, China.
authors: Ke
authors: K
authors: Meng
authors: Department of Ophthalmology, the Second Xiangya Hospital, Central South University, Changsha 410011, Hunan Province, China; Department of Ophthalmology, School of Medicine, Emory University, Atlanta, Georgia 30322, USA.
authors: Qing
authors: Q
authors: Zhang
keywords: drug delivery; gene delivery; nanomedicine; nanoparticles; uveal melanoma