title: Fe3O4@polydopamine Composite Theranostic Superparticles Employing Preassembled Fe3O4 Nanoparticles as the Core.
abstract: Iron oxide (Fe3O4), polydopamine (PDA), and in particular their composites are examples of the safest nanomaterials for developing multifunctional nanodevices to perform noninvasive tumor diagnosis and therapy. However, the structures and performances of Fe3O4-PDA nanocomposites should be further perfected to enhance the theranostic efficiency. In this work, we demonstrate the fabrication of PDA-capped Fe3O4 (Fe3O4@PDA) superparticles (SPs) employing preassembled Fe3O4 nanoparticles (NPs) as the cores. Owing to the collective effect of preassembled Fe3O4 NPs, the superparamagnetism and photothermal performance of Fe3O4@PDA SPs are greatly enhanced, thus producing nanodevices with improved magnetic resonance imaging (MRI)-guided photothermal efficiency. Systematical studies reveal that the molar extinction coefficient of the as-assembled Fe3O4 SPs is 3 orders of magnitude higher than that of individual Fe3O4 NPs. Also due to the high aggregation degree of Fe3O4 NPs, the T2-weighted MRI contrast is greatly enhanced for the SPs with r2 relaxivity of 230.5 mM(-1) s(-1), which is ∼2.5 times larger than that of individual Fe3O4 NPs. The photothermal stability, physiological stability, and biocompatibility, as well as the photothermal performance of Fe3O4 SPs, are further improved by enveloping with PDA shell.
authors: State Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University , Changchun 130012, People's Republic of China.
authors: Rui
authors: R
authors: Ge
authors: Department of Oral Pathology, School and Hospital of Stomatology, Jilin University , Changchun 130021, People's Republic of China.
authors: Xing
authors: X
authors: Li
authors: State Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University , Changchun 130012, People's Republic of China.
authors: Min
authors: M
authors: Lin
authors: Department of Oral Pathology, School and Hospital of Stomatology, Jilin University , Changchun 130021, People's Republic of China.
authors: Dandan
authors: D
authors: Wang
authors: State Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University , Changchun 130012, People's Republic of China.
authors: Shuyao
authors: S
authors: Li
authors: State Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University , Changchun 130012, People's Republic of China.
authors: Shuwei
authors: S
authors: Liu
authors: Department of Oral Pathology, School and Hospital of Stomatology, Jilin University , Changchun 130021, People's Republic of China.
authors: Qi
authors: Q
authors: Tang
authors: State Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University , Changchun 130012, People's Republic of China.
authors: Yi
authors: Y
authors: Liu
authors: China-Japan Union Hospital, Jilin University , Changchun 130033, People's Republic of China.
authors: Jinlan
authors: J
authors: Jiang
authors: Department of Spinal Surgery, The First Hospital of Jilin University , Changchun 130021, People's Republic of China , and.
authors: Lidi
authors: L
authors: Liu
authors: Department of Oral Pathology, School and Hospital of Stomatology, Jilin University , Changchun 130021, People's Republic of China.
authors: Hongchen
authors: H
authors: Sun
authors: State Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University , Changchun 130012, People's Republic of China.
authors: Hao
authors: H
authors: Zhang
authors: State Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University , Changchun 130012, People's Republic of China.
authors: Bai
authors: B
authors: Yang
keywords: Fe3O4 nanoparticle; polydopamine; self-assembly; superparticle; theranostics