title: Age-Related Differences in 1- and 12-Month Outcomes in Patients Undergoing Transcatheter Aortic Valve Implantation (from a Large Multicenter Data Repository).
abstract: Scarce data are available on the impact of age on transcatheter aortic valve implantation (TAVI) outcomes. We therefore, analyzed 1,845 consecutive patients from 9 Italian centers who underwent TAVI with the Corevalve Revalving System from September 2007 to March 2014; patients were dichotomized according to their age in the date of the procedure, as follows: 75 to 85 years old and >85 years old. End points were defined according to Valve Academic Research Consortium definitions. In-hospital, 30-day, and 1-year clinical and echocardiographic data were available for 100% of the patients included. Propensity matching was performed. Procedural success rates were high (>94%) and comparable between groups. Although worse baseline renal function was observed in the older group, the incidence of acute kidney injury after procedure was comparable (17.1% and 17.4%, respectively for the 75- to 85- and >85-year-old group, p = 0.877); importantly, >99% of acute kidney injury episodes in both groups were grades 1 and 2. Procedural complications rates were low without between-group differences. In-hospital death (3.7% and 4.6%, p = 0.379) and stroke/transient ischemic attack (1.9% and 1.9%, respectively, p = 0.960) were comparable. The 1-year death rates were 14.9% and 17.2% (p = 0.197) in the 75- to 85- and >85-year-old group, respectively. Cardiovascular death was observed in 7.8% and 7% (p = 0.542), while stroke/transient ischemic attack was demonstrated in 5.2% and 4.4% (p = 0.496), respectively. Results were sustained after propensity matching. In conclusion, advanced age did not negatively impact the outcomes of TAVI through 1-year after procedure.
authors: Department of Cardiology, Ferrarotto Hospital, University of Catania, Catania, Italy. Electronic address: gfattizzani@hotmail.com.
authors: Guilherme F
authors: GF
authors: Attizzani
authors: Department of Cardiology, Ferrarotto Hospital, University of Catania, Catania, Italy.
authors: Yohei
authors: Y
authors: Ohno
authors: Department of Cardiology, Scientific Institute S. Raffaele, Milan, Italy.
authors: Azeem
authors: A
authors: Latib
authors: Department of Cardiology, Azienda Ospedaliera Pisana, Pisa, Italy.
authors: Anna Sonia
authors: AS
authors: Petronio
authors: Department of Cardiology, Ospedali Civili, Brescia, Italy.
authors: Cristina
authors: C
authors: Giannini
authors: Department of Cardiology, Policlinico San Donato, San Donato, Italy.
authors: Federica
authors: F
authors: Ettori
authors: Department of Cardiology, Policlinico San Donato, San Donato, Italy.
authors: Claudia
authors: C
authors: Fiorina
authors: Department of Cardiology, Niguarda Ca'Granda Hospital, Milan, Italy.
authors: Francesco
authors: F
authors: Bedogni
authors: Department of Cardiology, Niguarda Ca'Granda Hospital, Milan, Italy.
authors: Nedy
authors: N
authors: Brambilla
authors: Department of Cardiology, Clinical Institute Humanitas, Milan, Italy.
authors: Giuseppe
authors: G
authors: Bruschi
authors: Department of Cardiology, Clinical Institute Humanitas, Milan, Italy.
authors: Paola
authors: P
authors: Colombo
authors: Department of Cardiology, Azienda Ospedaliera San Camillo Forlanini Hospital, Rome, Italy.
authors: Patrizia
authors: P
authors: Presbitero
authors: Department of Cardiology, Ospedale Civile, Legnano, Italy.
authors: Rosario
authors: R
authors: Fiorilli
authors: Department of Cardiology, Ospedale Civile, Legnano, Italy.
authors: Arnaldo
authors: A
authors: Poli
authors: Department of Cardiology, Ferrarotto Hospital, University of Catania, Catania, Italy.
authors: Marco
authors: M
authors: Barbanti
authors: Department of Cardiology, Scientific Institute S. Raffaele, Milan, Italy.
authors: Antonio
authors: A
authors: Colombo
authors: Department of Cardiology, University of Catania, Catania, Italy.
authors: Corrado
authors: C
authors: Tamburino
mesh_terms: D058186:Acute Kidney Injury / Q000453:epidemiology*; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D001024:Aortic Valve Stenosis / Q000000981:diagnostic imaging / Q000453:epidemiology / Q000601:surgery*; D002423:Cause of Death; D016208:Databases, Factual; D004452:Echocardiography; D005260:Female; D006801:Humans; D015994:Incidence; D002546:Ischemic Attack, Transient / Q000453:epidemiology*; D007558:Italy / Q000453:epidemiology; D008297:Male; D009026:Mortality; D011183:Postoperative Complications / Q000453:epidemiology*; D057216:Propensity Score; D051436:Renal Insufficiency, Chronic / Q000453:epidemiology; D012720:Severity of Illness Index; D020521:Stroke / Q000453:epidemiology*; D065467:Transcatheter Aortic Valve Replacement; D016896:Treatment Outcome