title: Fetal anemia, cerebellar hemorrhage and hypoplasia associated with congenital Parvovirus infection.
abstract: We report a case of fetal cerebellar hemorrhage and hypoplasia, identified by fetal MRI after intrauterine blood transfusion at 21 weeks' gestation for treatment of severe anemia due to congenital Parvovirus infection. Postnatal MRI confirmed atrophy of bilateral cerebellar hemispheres and inferior vermis. Cerebellar capillaries may be extremely susceptible to hemodynamic changes in the setting of intrauterine blood transfusion due to severe anemia. Although the correlation between fetal intracranial anomalies and Parvovirus infection remains unclear, in this population, a detailed evaluation of the brain parenchyma should be considered prior to and after intrauterine blood transfusion.
authors: a Division of Fetal and Transitional Medicine.
authors: Laura
authors: L
authors: Sanapo
authors: b Division of Radiology , Children's National Health System , Washington , DC , USA.
authors: Michael
authors: M
authors: Wien
authors: b Division of Radiology , Children's National Health System , Washington , DC , USA.
authors: Matthew T
authors: MT
authors: Whitehead
authors: b Division of Radiology , Children's National Health System , Washington , DC , USA.
authors: Anna
authors: A
authors: Blask
authors: c Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology , The George Washington University School of Medicine and Health Science , Washington , DC , USA.
authors: Michael
authors: M
authors: Gallagher
authors: d Division of Pediatric Infectious Diseases , Children's National Health System , Washington , DC , USA , and.|e Department of Pediatrics, Microbiology, Immunology and Tropical Medicine , The George Washington University School of Medicine and Health Science , Washington , DC , USA.
authors: Roberta L
authors: RL
authors: DeBiasi
authors: a Division of Fetal and Transitional Medicine.
authors: Adre
authors: A
authors: Du Plessis
mesh_terms: D000328:Adult; D000740:Anemia / Q000628:therapy / Q000821:virology*; D001805:Blood Transfusion, Intrauterine; D002531:Cerebellum / Q000002:abnormalities* / Q000000981:diagnostic imaging / Q000821:virology; D002658:Developmental Disabilities / Q000000981:diagnostic imaging / Q000821:virology; D038524:Diffusion Magnetic Resonance Imaging; D005260:Female; D005315:Fetal Diseases / Q000000981:diagnostic imaging / Q000821:virology*; D006801:Humans; D020300:Intracranial Hemorrhages / Q000000981:diagnostic imaging / Q000821:virology*; D009421:Nervous System Malformations / Q000000981:diagnostic imaging / Q000821:virology*; D010322:Parvoviridae Infections / Q000150:complications / Q000151:congenital* / Q000000981:diagnostic imaging; D011247:Pregnancy
keywords: Congenital Parvovirus; cerebellar hemorrhage; cerebellar hypoplasia; fetal anemia; intrauterine transfusion