title: Asthma and rhinitis have different genetic profiles for IL13, IL17A and GSTP1 polymorphisms.
abstract: BACKGROUND
  Asthma and rhinitis have a complex etiology, depending on multiple genetic and environmental risk factors. An increasing number of susceptibility genes are currently being identified, but the majority of reported associations have not been consistently replicated across populations of different genetic backgrounds.
  
  
  OBJECTIVE
  To evaluate whether polymorphisms of IL4R (rs1805015), IL13 (rs20541), IL17A (rs2275913) and GSTP1 (rs1695) genes are associated with rhinitis and/or asthma in adults of Portuguese ancestry.
  
  
  METHODS
  192 unrelated healthy individuals and 232 patients, 83 with rhinitis and 149 with asthma, were studied. All polymorphisms were detected by real time polymerase chain reaction (PCR) using TaqMan assays.
  
  
  RESULTS
  Comparing to controls, significant association with asthma was observed for GSTP1 rs1695 AA genotype (odds ratio (OR) - 1.96; 95% CI - 1.18 to 3.25; p=0.010). The association sustains for allergic asthma (OR - 2.17; 95% CI - 1.23 to 3.80; p=0.007). IL13 rs20541 GG genotype was associated with less susceptibility to asthma (OR - 0.55, 95% CI - 0.33 to 0.94, p=0.028). Among patients, IL17A rs2275913 AA genotype was less associated with asthma than with rhinitis (OR - 0.20; 95% CI of 0.07 to 0.56; p=0.002). A similar association was found for IL13 rs20541 GG genotype (OR - 0.48; 95% CI of 0.25 to 0.93; p=0.031). There were no significant differences in the distribution of allelic and genotypic frequencies between patients and controls for the IL4R polymorphism' analyzed.
  
  
  CONCLUSIONS
  These results support the existence of a significant association between GSTP1 rs1695 and IL13 rs20541 SNPs, with susceptibility to asthma, in the population studied. Different genotype profiles of IL17A and IL13 genes seem to influence the clinical pattern of disease expression mainly confined to the upper airways, as rhinitis, or including the lower airways, as asthma.
authors: Genetics Institute, Faculty of Medicine, University of Coimbra, Portugal. Electronic address: eresende@fmed.uc.pt.
authors: E P
authors: EP
authors: Resende
authors: Immunoallergology Department, Coimbra University Hospital, Portugal; CIMAGO - Centre of Investigation of Environment, Genetics and Oncobiology, Coimbra, Portugal.
authors: A
authors: A
authors: Todo-Bom
authors: Immunoallergology Department, Coimbra University Hospital, Portugal.
authors: C
authors: C
authors: Loureiro
authors: Laboratory of General Pathology, Faculty of Medicine, University of Coimbra, Portugal; CIMAGO - Centre of Investigation of Environment, Genetics and Oncobiology, Coimbra, Portugal.
authors: A
authors: A
authors: Mota Pinto
authors: Laboratory for Biostatistics and Medical Informatics, Faculty of Medicine, University of Coimbra, Portugal.
authors: B
authors: B
authors: Oliveiros
authors: Genetics Institute, Faculty of Medicine, University of Coimbra, Portugal.
authors: L
authors: L
authors: Mesquita
authors: Genetics Institute, Faculty of Medicine, University of Coimbra, Portugal; CIMAGO - Centre of Investigation of Environment, Genetics and Oncobiology, Coimbra, Portugal.
authors: H C
authors: HC
authors: Silva
mesh_terms: D000328:Adult; D001249:Asthma / Q000235:genetics*; D005260:Female; D051549:Glutathione S-Transferase pi / Q000235:genetics*; D006801:Humans; D018793:Interleukin-13 / Q000235:genetics*; D020381:Interleukin-17 / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D011174:Portugal; D012220:Rhinitis / Q000235:genetics*
chemical_list: C508717:IL17A protein, human; D018793:Interleukin-13; D020381:Interleukin-17; C496556:GSTP1 protein, human; D051549:Glutathione S-Transferase pi
keywords: Allergy; Asthma; GSTP1; Genetic polymorphism; Genetic profile; IL13; IL17A; IL4R; Rhinitis