title: Integrating Genomic Resources with Electronic Health Records using the HL7 Infobutton Standard.
abstract: The Clinical Genome Resource (ClinGen) Electronic Health Record (EHR) Workgroup aims to integrate ClinGen resources with EHRs. A promising option to enable this integration is through the Health Level Seven (HL7) Infobutton Standard. EHR systems that are certified according to the US Meaningful Use program provide HL7-compliant infobutton capabilities, which can be leveraged to support clinical decision-making in genomics.
  
  
  
  To integrate genomic knowledge resources using the HL7 infobutton standard. Two tactics to achieve this objective were: (1) creating an HL7-compliant search interface for ClinGen, and (2) proposing guidance for genomic resources on achieving HL7 Infobutton standard accessibility and compliance.
  
  
  
  We built a search interface utilizing OpenInfobutton, an open source reference implementation of the HL7 Infobutton standard. ClinGen resources were assessed for readiness towards HL7 compliance. Finally, based upon our experiences we provide recommendations for publishers seeking to achieve HL7 compliance.
  
  
  
  Eight genomic resources and two sub-resources were integrated with the ClinGen search engine via OpenInfobutton and the HL7 infobutton standard. Resources we assessed have varying levels of readiness towards HL7-compliance. Furthermore, we found that adoption of standard terminologies used by EHR systems is the main gap to achieve compliance.
  
  
  
  Genomic resources can be integrated with EHR systems via the HL7 Infobutton standard using OpenInfobutton. Full compliance of genomic resources with the Infobutton standard would further enhance interoperability with EHR systems.
authors: Bret S.E. Heale, Ph.D., 421 Wakara Way #140, Salt Lake City, UT 84108, Email: bheale@gmail.com.
authors: Bret S E
authors: BS
authors: Heale
authors: Casey Lynnette
authors: CL
authors: Overby
authors: Guilherme
authors: G
authors: Del Fiol
authors: Wendy S
authors: WS
authors: Rubinstein
authors: Donna R
authors: DR
authors: Maglott
authors: Tristan H
authors: TH
authors: Nelson
authors: Aleksandar
authors: A
authors: Milosavljevic
authors: Christa L
authors: CL
authors: Martin
authors: Scott R
authors: SR
authors: Goehringer
authors: Robert
authors: R
authors: Freimuth
authors: Marc S
authors: MS
authors: Williams
mesh_terms: D057225:Data Mining; D057286:Electronic Health Records; D023281:Genomics; D012015:Reference Standards; D057386:Search Engine / Q000592:standards; D014584:User-Computer Interface
keywords: Clinical information systems; HL7; clinical decision support; genetics; standards adoption