title: Annual life-stage regulation of lipid metabolism and storage and association with PPARs in a migrant species: the gray catbird (Dumetella carolinensis).
abstract: The annual cycle of a migrating bird involves metabolically distinct stages of substantial fatty acid storage and periods of increased fatty acid mobilization and utilization, and thus requires a great deal of phenotypic flexibility. Specific mechanisms directing stage transitions of lipid metabolism in migrants are largely unknown. This study characterized the role of the PPARs (peroxisome proliferator-activated receptors) in regulating migratory adiposity of the gray catbird (Dumetella carolinensis). Catbirds increased adipose storage during spring and autumn migration and showed increased rates of basal lipolysis during migration and tropical overwintering. Expression of the PPAR target genes involved in fat uptake and storage, FABPpm and PLIN3, increased during pre-migratory fattening. We found significant correlation between PPARγ and target gene expression in adipose but little evidence that PPARα expression levels drive metabolic regulation in liver during the migratory cycle.
authors: Department of Biology, Miami University, Oxford, OH 45056, USA.
authors: Keely R
authors: KR
authors: Corder
authors: Department of Biology, Miami University, Oxford, OH 45056, USA.
authors: Kristen J
authors: KJ
authors: DeMoranville
authors: Department of Biology, Miami University, Oxford, OH 45056, USA.
authors: David E
authors: DE
authors: Russell
authors: Department of Diabetes and Metabolic Diseases Research, Division of Cellular and Molecular Diabetes Research, Beckman Research Institute, City of Hope, Duarte, CA 91010, USA.
authors: Janice M
authors: JM
authors: Huss
authors: Department of Biology, Miami University, Oxford, OH 45056, USA schaefpj@miamioh.edu.
authors: Paul J
authors: 0000-0001-6230-8121
authors: PJ
authors: Schaeffer
mesh_terms: D000273:Adipose Tissue / Q000378:metabolism; D025041:Animal Migration / Q000502:physiology*; D000818:Animals; D001717:Birds / Q000235:genetics / Q000502:physiology*; D001823:Body Composition; D001835:Body Weight; D005786:Gene Expression Regulation; D005990:Glycerol / Q000378:metabolism; D008018:Life Cycle Stages; D050356:Lipid Metabolism; D008066:Lipolysis; D008099:Liver / Q000033:anatomy & histology; D009929:Organ Size; D000070778:Perilipin-1 / Q000235:genetics / Q000378:metabolism; D047492:Peroxisome Proliferator-Activated Receptors / Q000235:genetics / Q000378:metabolism*; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D012621:Seasons; D013045:Species Specificity
chemical_list: D000070778:Perilipin-1; D047492:Peroxisome Proliferator-Activated Receptors; D012333:RNA, Messenger; D005990:Glycerol
keywords: Adipose; Annual cycle; Avian migration; Liver; Passerine; Peroxisome proliferator-activated receptors