title: Effect of Aluminum, Iron, and Zinc Ions on the Assembly of Microtubules from Brain Microtubule Proteins.
abstract: Al(3+), Fe(3+), and Zn(2+) ions can disturb microtubule assembly from tubulin and microtubuleassociated proteins in rat brain. The main structural forms of these microtubules are rings and tangled bundles. These structures are formed only in the presence of Al(3+) and Fe(3+) ions. Therefore, Zn(2+) ions can be excluded from possible causes of structural abnormalities in microtubules during Alzheimer's disease. Al(3+) ions are the most probable etiological cause of Alzheimer's disease. The concentration of Al(3+) ions affecting the structure of microtubules is one order of magnitude lower than that of Fe(3+) ions (10 and 100 μM, respectively), which corresponds to their brain concentration reported in Alzheimer's disease.
authors: Laboratory of Biomolecular Screening, Institute of Physiologically Active Substances, Russian Academy of Sciences, Moscow Region, Chernogolovka, Russia. shevt@dio.ru.
authors: P N
authors: PN
authors: Shevtsov
authors: Laboratory of Biomolecular Screening, Institute of Physiologically Active Substances, Russian Academy of Sciences, Moscow Region, Chernogolovka, Russia.
authors: E F
authors: EF
authors: Shevtsova
authors: Laboratory of Neurochemistry, Research Center of Mental Health, Moscow, Institute of Physiologically Active Substances, Russian Academy of Sciences, Moscow Region, Chernogolovka, Russia.
authors: G Sh
authors: GSh
authors: Burbaeva
mesh_terms: D000535:Aluminum / Q000494:pharmacology*; D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism* / Q000648:ultrastructure; D003071:Cognition / Q000187:drug effects; D007501:Iron / Q000494:pharmacology*; D008568:Memory / Q000187:drug effects; D008868:Microtubule Proteins / Q000187:drug effects / Q000378:metabolism* / Q000648:ultrastructure; D008870:Microtubules / Q000187:drug effects / Q000378:metabolism* / Q000648:ultrastructure; D051381:Rats; D015032:Zinc / Q000494:pharmacology*
chemical_list: D008868:Microtubule Proteins; D000535:Aluminum; D007501:Iron; D015032:Zinc
keywords: Alzheimer’s disease; metal ions; microtubules