title: Pills-related severe adverse events: A case report in Taiwan.
abstract: OBJECTIVE
  To review and evaluate the potential adverse effects of these oral contraceptives (OCP) to overweight women.
  
  
  METHODS
  A 19-year-old college student, with a body mass index (BMI) of 35.2 kg/m(2), who received 2 months of OCP containing cyproterone and ethinyl estradiol for polycystic ovary syndrome (PCOS)-related menstrual problems was complicated with a thromboembolism-related life-threatened disease. After intensive care, including the use of an extracorporeal membrane oxygenation system, thrombolytic treatment, anticoagulant, and inferior vena filter, she recovered well without significant sequelae.
  
  
  CONCLUSIONS
  This case illustrates the risk of using OCPs, especially for those containing cyproterone and ethinyl estradiol components, as a treatment for menstrual problems in young women with PCOS and a high BMI.
authors: Department of Obstetrics and Gynecology, Taipei Medical University Hospital, Taipei, Taiwan; Department of Obstetrics and Gynecology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.
authors: Ching-Hui
authors: CH
authors: Chen
authors: Department of Obstetrics and Gynecology, Taipei Medical University Hospital, Taipei, Taiwan; Department of Obstetrics and Gynecology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.
authors: Hung-Yen
authors: HY
authors: Chin
authors: Department of Obstetrics and Gynecology, Taipei Medical University Hospital, Taipei, Taiwan.
authors: Huang-Hui
authors: HH
authors: Chen
authors: Department of Biochemistry and Molecular Cell Biology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan; Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei, Taiwan. Electronic address: hychang@tmu.edu.tw.
authors: Heng-Yu
authors: HY
authors: Chang
authors: Department of Obstetrics and Gynecology, Taipei Medical University Hospital, Taipei, Taiwan; Department of Obstetrics and Gynecology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan. Electronic address: weimin@tmu.edu.tw.
authors: Wei-Min
authors: WM
authors: Liu
mesh_terms: D000726:Androgen Antagonists / Q000009:adverse effects; D015992:Body Mass Index; D003277:Contraceptives, Oral, Combined / Q000009:adverse effects*; D003534:Cyproterone / Q000009:adverse effects*; D004967:Estrogens / Q000009:adverse effects; D004997:Ethinyl Estradiol / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008599:Menstruation Disturbances / Q000188:drug therapy* / Q000209:etiology; D050177:Overweight / Q000150:complications; D011085:Polycystic Ovary Syndrome / Q000150:complications; D013624:Taiwan; D013923:Thromboembolism / Q000139:chemically induced*; D055815:Young Adult
chemical_list: D000726:Androgen Antagonists; D003277:Contraceptives, Oral, Combined; D004967:Estrogens; D004997:Ethinyl Estradiol; D003534:Cyproterone
keywords: Diane-35; abnormal uterine bleeding; polycystic ovary syndrome; pulmonary embolism; thromboembolism