title: Cardiac Myosin Activators in Systolic Heart Failure: More Friend than Foe?
abstract: Despite the rising prevalence of HF, new evidence-based novel therapies for patients with worsening HF remain lacking, e.g., safe inotropic therapies. Traditional inotropes increase contractility by altering intracellular calcium flux, a pathway that may be responsible for the multitude of adverse effects associated with current options. Omecamtiv mecarbil, a direct myosin activator, increases contractility through a distinct pathway by increasing the proportion of myosin heads that are bound to actin in a high-affinity state. Phase II clinical trials in patients with chronic HF with this agent seem promising. A phase III trial investigating this therapy has not yet been pursued to date.
authors: Division of Cardiology, Stony Brook University School of Medicine, Stony Brook, NY, USA.
authors: Danyaal S
authors: DS
authors: Moin
authors: Division of Cardiology, Stony Brook University School of Medicine, Stony Brook, NY, USA.
authors: Julia
authors: J
authors: Sackheim
authors: Division of Cardiology, Stony Brook University School of Medicine, Stony Brook, NY, USA.
authors: Carine E
authors: CE
authors: Hamo
authors: Division of Cardiology, Stony Brook University School of Medicine, Stony Brook, NY, USA. Javed.Butler@stonybrookmedicine.edu.|Health Sciences Center, Stony Brook University Medical Center, T16-080, Stony Brook, NY, 11794, USA. Javed.Butler@stonybrookmedicine.edu.
authors: Javed
authors: J
authors: Butler
mesh_terms: D000818:Animals; D024722:Cardiac Myosins / Q000187:drug effects* / Q000378:metabolism; D002316:Cardiotonic Agents / Q000494:pharmacology* / Q000627:therapeutic use*; D004195:Disease Models, Animal; D054143:Heart Failure, Systolic / Q000188:drug therapy* / Q000473:pathology*; D006801:Humans; D009200:Myocardial Contraction / Q000187:drug effects*; D016032:Randomized Controlled Trials as Topic; D013318:Stroke Volume; D014508:Urea / Q000031:analogs & derivatives / Q000494:pharmacology / Q000627:therapeutic use
chemical_list: D002316:Cardiotonic Agents; C547293:omecamtiv mecarbil; D014508:Urea; D024722:Cardiac Myosins
keywords: ATOMIC-AHF; COSMIC-AHF; Heart failure; Inotrope; Omecamtiv mecarbil