title: Identification of Reliable Sulcal Patterns of the Human Rolandic Region.
abstract: A major feature of the human cortex is its huge morphological variability. Although a comprehensive literature about the sulco-gyral pattern of the central region is available from post-mortem data, a reliable and reproducible characterization from in vivo data is still lacking. The aim of this study is to test the reliability of morphological criteria of the central region sulci used in post-mortem data, when applied to in vivo magnetic resonance imaging (MRI) data. Thirty right-handed healthy individuals were included in the study. Automated segmentation and three dimensional (3D) surface-based rendering were obtained from clinical 3D T1-weighted MRI. Two senior radiologists labeled the three sulci composing the central region (precentral [PreCS], central [CS] and postcentral [PostCS]) and analyzed their morphological variations using 47 standard criteria derived from Ono's atlas based on post-mortem data. For each criterion, inter-rater concordance and comparison with the occurrence frequency provided in Ono's atlas were estimated. Overall, the sulcal pattern criteria derived from MRI data were highly reproducible between the raters with a high mean inter-rater concordance in the three sulci (CS: κ = 0.92 in left hemisphere/κ = 0.91 in right hemisphere; PreCS: κ = 0.91/κ = 0.93; PostCS: κ = 0.84/0.79). Only a very limited number of sulcal criteria significantly differed between the in vivo and the post-mortem data (CS: 2 criteria in the left hemisphere/3 criteria in the right hemisphere; PreCS: 3 in the left and right hemispheres; PostCS: 3 in the left hemisphere and 5 in the right hemisphere). Our study provides a comprehensive description of qualitative sulcal patterns in the central region from in vivo clinical MRI with high agreement with previous post-mortem data. Such identification of reliable sulcal patterns of the central region visible with standard clinical MRI data paves the way for the detection of subtle variations of the central sulcation associated with variations of normal or pathological functioning.
authors: Department of Neuroradiology, Centre Hospitalier Sainte-AnneParis, France; University Paris DescartesParis, France; Imaging Biomarkers of Brain Development and Disorders, INSERM, UMR 894Paris, France.
authors: Charles
authors: C
authors: Mellerio
authors: Department of Radiology, Hôpital de l'Enfant-Jésus, CHU de Québec Ville de Québec, QC, Canada.
authors: Marie-Noël
authors: MN
authors: Lapointe
authors: Department of Neuroradiology, Centre Hospitalier Sainte-AnneParis, France; Imaging Biomarkers of Brain Development and Disorders, INSERM, UMR 894Paris, France.
authors: Pauline
authors: P
authors: Roca
authors: Department of Neuroradiology, Centre Hospitalier Sainte-AnneParis, France; University Paris DescartesParis, France.
authors: Sylvain
authors: S
authors: Charron
authors: Department of Neuroradiology, Centre Hospitalier Sainte-AnneParis, France; University Paris DescartesParis, France.
authors: Laurence
authors: L
authors: Legrand
authors: Department of Neuroradiology, Centre Hospitalier Sainte-AnneParis, France; University Paris DescartesParis, France; Imaging Biomarkers of Brain Development and Disorders, INSERM, UMR 894Paris, France.
authors: Jean-François
authors: JF
authors: Meder
authors: Department of Neuroradiology, Centre Hospitalier Sainte-AnneParis, France; University Paris DescartesParis, France; Imaging Biomarkers of Brain Development and Disorders, INSERM, UMR 894Paris, France.
authors: Catherine
authors: C
authors: Oppenheim
authors: University Paris DescartesParis, France; Imaging Biomarkers of Brain Development and Disorders, INSERM, UMR 894Paris, France; Laboratory for the Psychology of Child Development and Education, CNRS, UMR 8240Paris, France; Institut Universitaire de FranceParis, France.
authors: Arnaud
authors: A
authors: Cachia
keywords: central sulcus; cortex; magnetic resonance imaging; post-central sulcus; pre-central sulcus; sulcal patterns