title: The acute anorexic effect of liraglutide, a GLP-1 receptor agonist, does not require functional leptin receptor, serotonin, and hypothalamic POMC and CART activities in mice.
abstract: The acute anorexic effect of liraglutide, a GLP-1 receptor agonist, did not require functional leptin receptor, serotonin, and hypothalamic proopiomelanocortin and cocaine amphetamine regulated transcript activities in mice, although decrease in functional hypothalamic orexin activity might be involved in the acute anorexic effect of liraglutide.
authors: Department of Diabetes Technology, Tohoku University Graduate School of Biomedical Engineering, Japan. Electronic address: katsu@trc.med.tohoku.ac.jp.
authors: Katsunori
authors: K
authors: Nonogaki
authors: Department of Diabetes Technology, Tohoku University Graduate School of Biomedical Engineering, Japan.
authors: Takao
authors: T
authors: Kaji
mesh_terms: D000818:Animals; D001067:Appetite Depressants / Q000494:pharmacology* / Q000627:therapeutic use; D004353:Drug Evaluation, Preclinical; D002149:Energy Intake / Q000187:drug effects; D007031:Hypothalamus / Q000378:metabolism; D000069450:Liraglutide / Q000494:pharmacology* / Q000627:therapeutic use; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009419:Nerve Tissue Proteins / Q000378:metabolism*; D011333:Pro-Opiomelanocortin / Q000378:metabolism*; D054411:Receptors, Leptin / Q000235:genetics / Q000378:metabolism*; D012701:Serotonin / Q000502:physiology*; D000098882:Cocaine- and Amphetamine-Regulated Transcript Protein; D000097789:Glucagon-Like Peptide-1 Receptor Agonists
chemical_list: D001067:Appetite Depressants; D009419:Nerve Tissue Proteins; D054411:Receptors, Leptin; D000098882:Cocaine- and Amphetamine-Regulated Transcript Protein; D012701:Serotonin; D011333:Pro-Opiomelanocortin; D000069450:Liraglutide; D000097789:Glucagon-Like Peptide-1 Receptor Agonists
keywords: 5-HT; Food intake; GLP-1 receptor; Liraglutide; Orexin; POMC