title: Selenium-binding protein 1 in head and neck cancer is low-expression and associates with the prognosis of nasopharyngeal carcinoma.
abstract: BACKGROUND
  Selenium-binding protein 1 (SELENBP1) expression is reduced markedly in many types of cancers and low SELENBP1 expression levels are associated with poor patient prognosis.
  
  
  METHODS
  SELENBP1 gene expression in head and neck squamous cell carcinoma (HNSCC) was analyzed with GEO dataset and characteristics of SELENBP1 expression in paraffin embedded tissue were summarized. Expression of SELENBP1 in nasopharyngeal carcinoma (NPC), laryngeal cancer, oral cancer, tonsil cancer, hypopharyngeal cancer and normal tissues were detected using immunohistochemistry, at last, 99 NPC patients were followed up more than 5 years and were analyzed the prognostic significance of SELENBP1.
  
  
  RESULTS
  Analysis of GEO dataset concluded that SELENBP1 gene expression in HNSCC was lower than that in normal tissue (P < 0.01), but there was no significant difference of SELENBP1 gene expression in different T-stage and N-stage (P > 0.05). Analysis of pathological section concluded that SELENBP1 in the majority of HNSCC is low expression and in cancer nests is lower expression than surrounding normal tissue, even associated with the malignant degree of tumor. Further study indicated the low SELENBP1 expression group of patients with NPC accompanied by poor overall survival and has significantly different comparing with the high expression group.
  
  
  CONCLUSIONS
  SELENBP1 expression was down-regulated in HNSCC, but has no associated with T-stage and N-stage of tumor. Low expression of SELENBP1 in patients with NPC has poor over survival, so SELENBP1 could be a novel biomarker for predicting prognosis.
authors: Department of Otolaryngology Head and Neck Surgery, Central Hospital of Enshi Autonomous Prefecture, Enshi Autonomous Prefecture, Hubei Province Research institute of Otolaryngology Head and Neck Surgery, Renmin Hospital of Wuhan University, Wuhan Affiliated Hospital of Xuzhou Medical College, Xuzhou, Jiangsu Province, China.
authors: Fasheng
authors: F
authors: Chen
authors: Chen
authors: C
authors: Chen
authors: Yangang
authors: Y
authors: Qu
authors: Hua
authors: H
authors: Xiang
authors: Qingxiu
authors: Q
authors: Ai
authors: Fei
authors: F
authors: Yang
authors: Xueping
authors: X
authors: Tan
authors: Yi
authors: Y
authors: Zhou
authors: Guang
authors: G
authors: Jiang
authors: Zixiong
authors: Z
authors: Zhang
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000737:chemistry / Q000235:genetics* / Q000473:pathology*; D018572:Disease-Free Survival; D015536:Down-Regulation; D005500:Follow-Up Studies; D015870:Gene Expression; D006801:Humans; D007012:Hypopharyngeal Neoplasms / Q000737:chemistry / Q000235:genetics* / Q000473:pathology; D007013:Hypopharynx / Q000737:chemistry; D007822:Laryngeal Neoplasms / Q000737:chemistry / Q000235:genetics* / Q000473:pathology; D007830:Larynx / Q000737:chemistry; D009055:Mouth / Q000737:chemistry; D009062:Mouth Neoplasms / Q000737:chemistry / Q000235:genetics* / Q000473:pathology; D009303:Nasopharyngeal Neoplasms / Q000737:chemistry / Q000235:genetics* / Q000473:pathology; D009305:Nasopharynx / Q000737:chemistry; D060787:Neoplasm Grading; D009367:Neoplasm Staging; D014066:Palatine Tonsil / Q000737:chemistry; D051137:Selenium-Binding Proteins / Q000032:analysis / Q000235:genetics*; D015996:Survival Rate; D014067:Tonsillar Neoplasms / Q000737:chemistry / Q000235:genetics* / Q000473:pathology
chemical_list: C495175:SELENBP1 protein, human; D051137:Selenium-Binding Proteins