title: Risk factors of type 1 gastric neuroendocrine neoplasia in patients with chronic atrophic gastritis. A retrospective, multicentre study.
abstract: The aim of this retrospective study was to evaluate the presence of risk factors for a type 1 gastric neuroendocrine neoplasia in a large cohort of patients with chronic atrophic gastritis. The study design consisted of an Italian multicentre, retrospective analysis. The study included all consecutive patients with chronic atrophic gastritis with or without type 1 gastric neuroendocrine neoplasias followed at the participating centres. Two hundred and twenty-nine patients with chronic atrophic gastritis were enroled at the participating centres. A total of 207 patients (154 female, 53 males, median age: 56.0 years) were included in the final analysis. One hundred and twenty-six patients had chronic atrophic gastritis without a gastric neuroendocrine neoplasia and 81 had a chronic atrophic gastritis with type 1 gastric neuroendocrine neoplasia. The median Chromogranin A level, evaluated in 141 patients, was 52.0 U/L. At upper gastrointestinal endoscopy, atrophy of the gastric mucosa was mild/moderate in 137 patients and severe in 68. Intestinal metaplasia of the corpus was present in 168 patients. At histological examination, 81 patients had a gastric neuroendocrine neoplasia (42 patients had a NET G1 and 33 a NET G2). The median Ki67 index was 2.0 %. At univariate and multivariate analysis, the risk factors for a gastric neuroendocrine neoplasia were: male gender, chromogranin A greater than 61 U/L, presence of intestinal metaplasia and age equal to or greater than 59 years. Chromogranin A greater than 61 U/L, the presence of intestinal metaplasia and male gender were independent risk factors for a type 1 gastric neuroendocrine neoplasia in patients with chronic atrophic gastritis.
authors: Department of Medical and Surgical Sciences, S.Orsola-Malpighi University Hospital, Bologna, Italy. davide.campana@unibo.it.
authors: Davide
authors: http://orcid.org/0000-0002-4615-7340
authors: D
authors: Campana
authors: Division of Endoscopy and Unit of Gastrointestinal and Neuroendocrine Tumours, European Institute of Oncology, Milan, Italy.
authors: Davide
authors: D
authors: Ravizza
authors: Department of Medical Oncology, Multidisciplinary NET Centre, Umbria Regional Cancer Network, Umbria, Italy.
authors: Piero
authors: P
authors: Ferolla
authors: Division of Endocrinology, Department of Clinical Medicine and Surgery, "Federico II" University of Naples, Naples, Italy.
authors: Antongiulio
authors: A
authors: Faggiano
authors: Endocrinology and Metabolism Unit, University Hospital S. Maria della Misericordia, Udine, Italy.
authors: Franco
authors: F
authors: Grimaldi
authors: Endocrinology, Department of Internal Medicine and Medical Specialties (DiMI) and Centre of Excellence for Biomedical Research (CEBR), University of Genova, Genoa, Italy.|IRCCS-AOU San Martino-IST, Genova, Italy.
authors: Manuela
authors: M
authors: Albertelli
authors: Department of Medical and Surgical Sciences, S.Orsola-Malpighi University Hospital, Bologna, Italy.
authors: Claudio
authors: C
authors: Ricci
authors: Dipartimento della medicina diagnostica e della prevenzione, S.Orsola-Malpighi University Hospital, Bologna, Italy.
authors: Donatella
authors: D
authors: Santini
authors: Department of Experimental, Diagnostic and Specialty medicine S.Orsola-Malpighi University Hospital, Bologna, Italy.
authors: Nicole
authors: N
authors: Brighi
authors: Division of Endoscopy and Unit of Gastrointestinal and Neuroendocrine Tumours, European Institute of Oncology, Milan, Italy.
authors: Nicola
authors: N
authors: Fazio
authors: Division of Endocrinology, Department of Clinical Medicine and Surgery, "Federico II" University of Naples, Naples, Italy.
authors: Annamaria
authors: A
authors: Colao
authors: Endocrinology, Department of Internal Medicine and Medical Specialties (DiMI) and Centre of Excellence for Biomedical Research (CEBR), University of Genova, Genoa, Italy.|IRCCS-AOU San Martino-IST, Genova, Italy.
authors: Diego
authors: D
authors: Ferone
authors: Department of Medical and Surgical Sciences, S.Orsola-Malpighi University Hospital, Bologna, Italy.
authors: Paola
authors: P
authors: Tomassetti
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D005757:Gastritis, Atrophic / Q000150:complications* / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D018358:Neuroendocrine Tumors / Q000209:etiology* / Q000473:pathology; D012189:Retrospective Studies; D012307:Risk Factors; D013274:Stomach Neoplasms / Q000209:etiology* / Q000473:pathology; D055815:Young Adult
keywords: Chromogranin A; Chronic atrophic gastritis; Gastric carcinoid; Gastrin; Neuroendocrine tumours