title: The Hippo pathway in cellular reprogramming and regeneration of different organs.
abstract: We have a limited ability to stimulate cells in damaged tissues to regenerate properly patterned and functional organs. Excitingly, however, recent work shows that experimental modulation of the Hippo pathway can promote the regeneration of several organs in mice. The Hippo pathway plays pivotal and specific roles in organ growth, cellular plasticity, and stem cell biology, which are all important for regeneration. In this review we survey and compare the effects of experimental manipulation of Hippo signaling in mouse on the development, homeostasis, and regeneration of the heart, liver, intestine, and other organs. We also discuss the potential of targeting the Hippo pathway as a therapeutic approach for regenerative medicine.
authors: VIB Center for the Biology of Disease and KU Leuven Center for Human Genetics, University of Leuven, 3000 Leuven, Belgium.
authors: Iván M
authors: IM
authors: Moya
authors: VIB Center for the Biology of Disease and KU Leuven Center for Human Genetics, University of Leuven, 3000 Leuven, Belgium. Electronic address: georg.halder@vib.be.
authors: Georg
authors: G
authors: Halder
mesh_terms: D000818:Animals; D065150:Cellular Reprogramming; D006801:Humans; D009369:Neoplasms / Q000473:pathology; D009928:Organ Specificity; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism*; D012038:Regeneration; D015398:Signal Transduction; D013234:Stem Cells / Q000378:metabolism
chemical_list: D017346:Protein Serine-Threonine Kinases