title: New Adamantyl Chalcones: Synthesis, Antimicrobial and Anticancer Activities.
abstract: BACKGROUND
  A new variety of adamantyl chalcones (2, 3a-o) were efficiently prepared by Claisen-Schmidt reaction of 4-adamantyl acetophenone 2 with a serie of aromatic aldehydes in good yields. Their structures were confirmed by spectroscopic data, and the relative configuration of 3d was confirmed by X-ray crystallography. All synthesized chalcones were tested against a panel of Grampositive and Gram-negative bacteria and pathogenic fungus and displayed strong antibacterial activity against Enterococcus faecali 29212, Pseudomonas aeruginosa ATCC27853, Escherichia coli and interesting antifungal activity against Candida glabrata ATCC 90030.
  
  
  RESULTS
  The effect of these compounds was also tested in vitro as antitumor on Miapaca2 cells. Compounds also showed anticancer activity against human pancreas cancer cell MiaPaca2.
authors: Aouatef
authors: A
authors: Tabbi
authors: Department of chemistry, Faculty of sciences, Mentouri University, 25000 Constantine, Algeria.
authors: Dahmane
authors: D
authors: Tebbani
authors: Angelamaria
authors: A
authors: Caporale
authors: Carmela
authors: C
authors: Saturnino
authors: S F
authors: SF
authors: Nabavi
authors: Palma
authors: P
authors: Giuseppe
authors: Claudio
authors: C
authors: Arra
authors: Zerrin
authors: Z
authors: Canturk
authors: Gulhan
authors: G
authors: Turan-Zitouni
authors: Hocine
authors: H
authors: Merazig
authors: Eduardo
authors: E
authors: Sobarzo-Sanchez
authors: Luca
authors: L
authors: Rastrelli
mesh_terms: D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D045744:Cell Line, Tumor; D047188:Chalcones / Q000138:chemical synthesis* / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests
chemical_list: D000890:Anti-Infective Agents; D000970:Antineoplastic Agents; D047188:Chalcones