title: DRESS Syndrome Following Metformin Administration: A Case Report and Review of the Literature.
abstract: The drug rash with eosinophilia and systemic symptoms syndrome also known as DRESS syndrome refers to an idiosyncratic drug reaction commonly characterized by rashes, fever, lymphadenopathy, and internal organ involvement. We report a case of this syndrome in a 40-year-old man presenting with a rash, generalized pruritus, lymphadenopathy, and eosinophilia after metformin treatment. To the best of our knowledge, this is the first report linking metformin to the DRESS syndrome. The patient improved remarkably with drug withdrawal. A high index of clinical suspicion is emphasized to facilitate prompt diagnosis of medication related adverse effect and its discontinuation. In this article, we review the recent literature on DRESS syndrome.
authors: Department of Medicine, Presence St Joseph Hospital, Chicago, IL.
authors: Prakruthi
authors: P
authors: Voore
authors: Chibuzo
authors: C
authors: Odigwe
authors: Aibek E
authors: AE
authors: Mirrakhimov
authors: Dana
authors: D
authors: Rifai
authors: Nkemakolam A
authors: NA
authors: Iroegbu
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy*; D063926:Drug Hypersensitivity Syndrome / Q000209:etiology*; D006801:Humans; D007004:Hypoglycemic Agents / Q000009:adverse effects*; D008297:Male; D008687:Metformin / Q000009:adverse effects*; D011565:Psoriasis / Q000150:complications; D013207:Staphylococcal Skin Infections / Q000150:complications / Q000188:drug therapy
chemical_list: D000900:Anti-Bacterial Agents; D007004:Hypoglycemic Agents; D008687:Metformin