title: Comparative Study of PVC-Free All-Solid-State, PVC Membrane, and Carbon Paste Ion-Selective Electrodes for the Determination of Dapoxetine Hydrochloride in Pharmaceutical Formulation.
abstract: The potentiometric response characteristics and analytical applications of a poly(vinyl chloride) (PVC)-free all-solid-state ion-selective electrode for dapoxetine hydrochloride (DAP) are examined. The Nernstian response of the electrode was evaluated by comparison with PVC-based liquid membrane and carbon paste electrodes. The PVC-free electrode is prepared by direct incorporation of dapoxetine-tetraphenyl borate (DAP-TPB) as a sensing element into a commercial nail varnish containing cellulose acetate propionate. The composite was applied onto a 3 mm diameter graphite disk electrode. The electrode exhibited a Nernstian slope of 56.0 mV/decade in the concentration range of 1 × 10-4 to 1 × 10-2 mol/L with an LOD of 2 × 10-5 mol/L. The electrode is independent of pH in the range of 2 to 6 and showed good selectivity for DAP with respect to a large number of inorganic cations and amino acids. Comparable Nernstian slope, sensitivity, pH range, and selectivity pattern were obtained with a PVC membrane and a carbon paste incorporating DAP-TPB as a sensing element and dioctylphthalate as a solvent mediator. The electrodes were used for the determination of DAP in pure solution and in tablets without extraction with high accuracy and precision (RSD ≤ 2%). The nail varnish solid-state electrode is simple, economical, and rapid when compared with PVC membrane and carbon paste electrodes.
authors: Cairo University, Faculty of Pharmacy, Department of Analytical Chemistry, Giza, Egypt.
authors: Azza
authors: A
authors: Aziz
authors: Cairo University, Faculty of Pharmacy, Department of Analytical Chemistry, Giza, Egypt.
authors: Nesrin
authors: N
authors: Khamees
authors: National Organization for Drug Control and Research, Department of Pharmaceutical Chemistry, 9 Abou-Hazem St, Giza, Egypt.
authors: Tagreed Abdel-Fattah
authors: TA
authors: Mohamed
authors: National Organization for Drug Control and Research, Department of Pharmaceutical Chemistry, 9 Abou-Hazem St, Giza, Egypt.
authors: Abeer Rashad
authors: AR
authors: Derar
mesh_terms: D001596:Benzylamines / Q000032:analysis*; D002244:Carbon / Q000737:chemistry*; D004339:Drug Compounding; D004566:Electrodes; D015394:Molecular Structure; D009281:Naphthalenes / Q000032:analysis*; D011143:Polyvinyl Chloride / Q000737:chemistry*
chemical_list: D001596:Benzylamines; D009281:Naphthalenes; D002244:Carbon; D011143:Polyvinyl Chloride; C080598:dapoxetine