title: Angiotensinogen-M235T as a risk factor for myocardial infarction in Asian populations: a genetic association study and a bioinformatics approach.
abstract: OBJECTIVE
  To investigate if there is an association between M235T polymorphism of angiotensinogen gene and myocardial infarction (MI) risk and perform a meta-analysis and an in silico approach.
  
  
  METHODS
  This case-control study included 340 participants (155 MI patients and 185 controls) examined at Kashan University of Medical Sciences (Kashan, Iran) between 2013 and 2015. Meta-analysis included 25 studies with 6334 MI patients and 6711 controls. Bioinformatics tools were applied to evaluate the impact of M235T polymorphism on angiotensinogen function and structure.
  
  
  RESULTS
  Genetic association study revealed a significant association between TT genotype (odds ratio [OR] 2.08, 95% confidence interval [CI] 1.08-4.00, P=0.029) and T allele (OR 1.45, 95% CI 1.06-1.99, P=0.021) and MI risk. Meta-analysis also revealed a significant association between M235T polymorphism and MI risk in allelic (OR 1.55, 95% CI 1.10-2.18, P=0.012) and recessive (OR 1.69, 95% CI 1.13-2.53, P=0.010) models within Asian population. In silico-analysis revealed that M235T fundamentally changed the function of angiotensinogen (score 32; expected accuracy 66%).
  
  
  CONCLUSIONS
  Our study suggests that M235T polymorphism might be a helpful biomarker for screening of susceptible individuals for MI in Asian population.
authors: Fariba
authors: F
authors: Raygan
authors: Mohammad Karimian, Gametogenesis Research Center, Kashan University of Medical Sciences, Kashan, Iran, mdkarimian@gmail.com.
authors: Mohammad
authors: M
authors: Karimian
authors: Atefeh
authors: A
authors: Rezaeian
authors: Bahareh
authors: B
authors: Bahmani
authors: Mohaddeseh
authors: M
authors: Behjati
mesh_terms: D000368:Aged; D000483:Alleles; D000808:Angiotensinogen / Q000235:genetics*; D044466:Asian People / Q000235:genetics; D016022:Case-Control Studies; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000235:genetics*; D016017:Odds Ratio; D011110:Polymorphism, Genetic; D012307:Risk Factors
chemical_list: D000808:Angiotensinogen