title: Three-dimensional echocardiography in various types of heart disease: a comparison study of magnetic resonance imaging and 64-slice computed tomography in a real-world population.
abstract: Accurate quantification of left ventricular (LV) volumes [end-diastolic volume (EDV) and end-systolic volume (ESV)] and ejection fraction (EF) is of critical importance. The development of real-time three-dimensional echocardiography (RT3DE) has shown better correlation than two-dimensional (2D) echocardiography with magnetic resonance imaging (MRI) measurements. The aim of our study was to assess the accuracy of RT3DE and 64-slice computed tomography (CT) in the evaluation of LV volumes and function using MRI as the reference standard in a real-world population with various types of heart disease with different chamber geometry.
  
  
  
  The study population consisted of 66 patients referred for cardiac MRI for various pathologies. All patients underwent cardiac MRI, and RT3DE and 64 slices CT were then performed on a subsequent day. The study population was then divided into 5 clinical groups depending on the underlying heart disease.
  
  
  
  RT3DE volumes correlated well with MRI values (R2values: 0.90 for EDV and 0.94 for ESV). RT3DE measurements of EF correlated well with MRI values (R2= 0.86). RT3DE measurements resulted in slightly underestimated values of both EDV and ESV, as reflected by biases of -9.18 and -4.50 mL, respectively. Comparison of RT3DE and MRI in various types of cardiomyopathies showed no statistical difference between different LV geometrical patterns.
  
  
  
  These results confirm that RT3DE has good accuracy in everyday clinical practice and can be of clinical utility in all types of cardiomyopathy independently of LV geometric pattern, LV diameter or wall thickness, taking into account a slight underestimation of LV volumes and EF compared to MRI.
authors: UO Cardiologia, Maria Cecilia Hospital-GVM Care and Research, Cotignola, RA, Italy. angelo.squeri@yahoo.it.
authors: Angelo
authors: A
authors: Squeri
authors: UO Cardiologia, Maria Cecilia Hospital-GVM Care and Research, Cotignola, RA, Italy.
authors: Stefano
authors: S
authors: Censi
authors: Dipartimento Cardio-Nefro-Polmonare, Azienda Ospedaliero Universitaria di Parma, Parma, Italy.
authors: Claudio
authors: C
authors: Reverberi
authors: Dipartimento Cardio-Nefro-Polmonare, Azienda Ospedaliero Universitaria di Parma, Parma, Italy.
authors: Nicola
authors: N
authors: Gaibazzi
authors: UO Cardiologia, Maria Cecilia Hospital-GVM Care and Research, Cotignola, RA, Italy.
authors: Marco
authors: M
authors: Baldelli
authors: Dipartimento Cardio-Nefro-Polmonare, Azienda Ospedaliero Universitaria di Parma, Parma, Italy.
authors: Simone Maurizio
authors: SM
authors: Binno
authors: Dipartimento di Scienze Statistiche, Università di Bologna, Bologna, Italy.
authors: Enrico
authors: E
authors: Properzi
authors: UO Cardiologia, Maria Cecilia Hospital-GVM Care and Research, Cotignola, RA, Italy.
authors: Stefano
authors: S
authors: Bosi
mesh_terms: D000368:Aged; D019560:Echocardiography, Three-Dimensional / Q000379:methods*; D005260:Female; D006331:Heart Diseases / Q000175:diagnosis / Q000000981:diagnostic imaging*; D006352:Heart Ventricles / Q000000981:diagnostic imaging*; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013318:Stroke Volume; D014057:Tomography, X-Ray Computed / Q000379:methods*
keywords: Computed tomography; Ejection fraction; Left ventricular volumes; Magnetic resonance; Real-time three dimensional echocardiography