title: Comparison of childhood thyroid cancer prevalence among 3 areas based on external radiation dose after the Fukushima Daiichi nuclear power plant accident: The Fukushima health management survey.
abstract: The 2011 Great East Japan Earthquake led to a subsequent nuclear accident at the Fukushima Daiichi Nuclear Power Plant. In its wake, we sought to examine the association between external radiation dose and thyroid cancer in Fukushima Prefecture. We applied a cross-sectional study design with 300,476 participants aged 18 years and younger who underwent thyroid examinations between October 2011 and June 2015. Areas within Fukushima Prefecture were divided into three groups based on individual external doses (≥1% of 5 mSv, <99% of 1 mSv/y, and the other). The odds ratios (ORs) and 95% confidence intervals of thyroid cancer for all areas, with the lowest dose area as reference, were calculated using logistic regression models adjusted for age and sex. Furthermore, the ORs of thyroid cancer for individual external doses of 1 mSv or more and 2 mSv or more, with the external dose less than 1 mSv as reference, were calculated. Prevalence of thyroid cancer for the location groups were 48/100,000 for the highest dose area, 36/100,000 for the middle dose area, and 41/100,000 for the lowest dose area. Compared with the lowest dose area, age-, and sex-adjusted ORs (95% confidence intervals) for the highest-dose and middle-dose areas were 1.49 (0.36-6.23) and 1.00 (0.67-1.50), respectively. The duration between accident and thyroid examination was not associated with thyroid cancer prevalence. There were no significant associations between individual external doses and prevalence of thyroid cancer. External radiation dose was not associated with thyroid cancer prevalence among Fukushima children within the first 4 years after the nuclear accident.
authors: Radiation Medical Science Center for the Fukushima Health Management Survey, Fukushima Medical University Department of Epidemiology Department of Public Health Department of Radiation Health Management Department of Thyroid and Endocrinology Department of Laboratory Medicine Department of Radiation Physics and Chemistry Department of Radiation Life Sciences, Fukushima Medical University School of Medicine, Fukushima Atomic Bomb Disease Institute, Nagasaki University, Nagasaki, Japan.
authors: Tetsuya
authors: T
authors: Ohira
authors: Hideto
authors: H
authors: Takahashi
authors: Seiji
authors: S
authors: Yasumura
authors: Akira
authors: A
authors: Ohtsuru
authors: Sanae
authors: S
authors: Midorikawa
authors: Satoru
authors: S
authors: Suzuki
authors: Toshihiko
authors: T
authors: Fukushima
authors: Hiroki
authors: H
authors: Shimura
authors: Tetsuo
authors: T
authors: Ishikawa
authors: Akira
authors: A
authors: Sakai
authors: Shunichi
authors: S
authors: Yamashita
authors: Koichi
authors: K
authors: Tanigawa
authors: Hitoshi
authors: H
authors: Ohto
authors: Masafumi
authors: M
authors: Abe
authors: Shinichi
authors: S
authors: Suzuki
mesh_terms: D000293:Adolescent; D044963:Biopsy, Fine-Needle; D002648:Child; D002675:Child, Preschool; D003430:Cross-Sectional Studies; D004781:Environmental Exposure / Q000009:adverse effects*; D005260:Female; D062406:Fukushima Nuclear Accident; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007564:Japan / Q000453:epidemiology; D008297:Male; D008403:Mass Screening; D016017:Odds Ratio; D015995:Prevalence; D011829:Radiation Dosage; D013964:Thyroid Neoplasms / Q000000981:diagnostic imaging / Q000453:epidemiology* / Q000473:pathology*; D014463:Ultrasonography