title: Fluoroquinolone Resistance among Clonal Complex 1 Group B Streptococcus Strains.
abstract: Fluoroquinolone resistance in group B Streptococcus is increasingly being reported worldwide. Here, we correlated fluoroquinolone resistance with mutations in gyrA, gyrB, parC, and parE genes, identified by mining whole-genome sequencing (WGS) data of 190 clonal complex 1 group B Streptococcus strains recovered from patients with invasive diseases in North America. We report a high prevalence of fluoroquinolone resistance (12%) among GBS strains in our collection. Our approach is the first step towards accurate prediction of fluoroquinolone resistance from WGS data in this opportunistic pathogen.
authors: Public Health Ontario Laboratory, Toronto, ON, Canada M5G 1M1.
authors: Alefiya
authors: 0000-0003-3103-5823
authors: A
authors: Neemuchwala
authors: Public Health Ontario Laboratory, Toronto, ON, Canada M5G 1M1.
authors: Sarah
authors: S
authors: Teatero
authors: Public Health Ontario Laboratory, Toronto, ON, Canada M5G 1M1; Department of Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto, Toronto, ON, Canada M5S 1A1.
authors: Samir N
authors: SN
authors: Patel
authors: Public Health Ontario Laboratory, Toronto, ON, Canada M5G 1M1; Department of Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto, Toronto, ON, Canada M5S 1A1.
authors: Nahuel
authors: 0000-0001-9553-3798
authors: N
authors: Fittipaldi