title: Association between DPP4 gene polymorphism and serum lipid levels in Chinese type 2 diabetes individuals.
abstract: OBJECTIVE
  The goal of the genetic investigation was to identify the associations of serum lipid levels and DPP-4 variants in Chinese type 2 diabetes patients.
  
  
  METHODS
  We detected four variants of the DPP4 gene in 190 Chinese individuals with type 2 diabetes and tested for an association with dyslipidemia in 82 selected samples. Data including basic information, HbA1c, FPG, serum lipid parameters were collected. Statistical analysis was performed by SPSS 13.0 through ANOVA and χ2test.
  
  
  RESULTS
  The genetic polymorphism of rs4664443, rs3788979, rs7608798 and rs1558957 in Chinese type 2 diabetes were consistent with Hardy-Weinberg equilibrium. The CT genotype of rs4664443 suffered from higher serum TG (P=0.013), LDL (P=0.044) and ApoB (P=0.006) levels, whereas the TT genotype of rs7608798 exhibited a lower serum TG level (P=0.037). For rs3788979, the serum TG level (P=0.034) and BMI (P=0.04) were significantly different among genotypes. Moreover, serum TG and TC levels and BMI showed a positive correlation with the number unfavorable alleles, and individuals with more than two unfavorable alleles had higher TG (P=0.004), TC (P=0.011), and BMI (P=0.044) values.
  
  
  CONCLUSIONS
  This is the first study to investigate DPP4 allelic distributions and their association with dyslipidemia in Chinese type 2 diabetes patients, which may have clinical significance.
authors: School of Pharmacy, Shandong University, Jinan, Shandong Province, PR China; Department of Pharmacy, The Affiliated Hospital of Qingdao University, Qingdao, Shandong Province, PR China.
authors: Xiaomin
authors: X
authors: Xing
authors: Department of Pharmacy, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan, Shandong Province, PR China.
authors: Yi
authors: Y
authors: Han
authors: School of Medicine, Shandong University, Jinan, Shandong Province, PR China.
authors: Xiaojun
authors: X
authors: Zhou
authors: School of Pharmacy, Shandong University, Jinan, Shandong Province, PR China.
authors: Bo
authors: B
authors: Zhang
authors: Department of Pharmacy, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan, Shandong Province, PR China.
authors: Yan
authors: Y
authors: Li
authors: Department of Cardiovascular, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan, Shandong Province, PR China.
authors: Zhongsu
authors: Z
authors: Wang
authors: Department of Endocrinology, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan, Shandong Province, PR China. Electronic address: liaolin009@sina.com.
authors: Lin
authors: L
authors: Liao
authors: Department of Pharmacy, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan, Shandong Province, PR China. Electronic address: sulequnqfs@163.com.
authors: Lequn
authors: L
authors: Su
mesh_terms: D000483:Alleles; D044466:Asian People; D015992:Body Mass Index; D002681:China; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000235:genetics*; D018819:Dipeptidyl Peptidase 4 / Q000097:blood* / Q000235:genetics*; D050171:Dyslipidemias / Q000097:blood / Q000235:genetics; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D005838:Genotype; D006801:Humans; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide
chemical_list: D008055:Lipids; C042807:DPP4 protein, human; D018819:Dipeptidyl Peptidase 4
keywords: DPP4; Polymorphism; Serum lipid levels; Type 2 diabetes