title: Safety of Biologic Agents in Elderly Patients with Rheumatoid Arthritis.
abstract: To clarify the safety of biologics in elderly patients with rheumatoid arthritis.
  
  
  
  Biologics were analyzed for safety in relation to age in 309 patients.
  
  
  
  Young (< 65 yrs old, n = 174), elderly (65-74 yrs old, n = 86), and older elderly patients (≥ 75 yrs old, n = 49) were enrolled. Although the incidence of adverse events causing treatment withdrawal was significantly higher in elderly and old elderly compared with young patients, no difference was found between elderly and older elderly patients. Pulmonary complications were independent risk factors.
  
  
  
  Old patients require special attention, although the safety of biologics in those ≥ 75 years old and 65-74 was comparable.
authors: From the Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan.|A. Murota, MD, PhD, Postdoctoral Fellow, Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine; Y. Kaneko, MD, PhD, Assistant Professor, Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine; K. Yamaoka, MD, PhD, Associate Professor, Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine; T. Takeuchi, MD, PhD, Professor, Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine.
authors: Atsuko
authors: A
authors: Murota
authors: From the Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan.|A. Murota, MD, PhD, Postdoctoral Fellow, Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine; Y. Kaneko, MD, PhD, Assistant Professor, Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine; K. Yamaoka, MD, PhD, Associate Professor, Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine; T. Takeuchi, MD, PhD, Professor, Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine.
authors: Yuko
authors: Y
authors: Kaneko
authors: From the Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan.|A. Murota, MD, PhD, Postdoctoral Fellow, Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine; Y. Kaneko, MD, PhD, Assistant Professor, Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine; K. Yamaoka, MD, PhD, Associate Professor, Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine; T. Takeuchi, MD, PhD, Professor, Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine.
authors: Kunihiro
authors: K
authors: Yamaoka
authors: From the Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan. tsutake@z5.keio.jp.|A. Murota, MD, PhD, Postdoctoral Fellow, Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine; Y. Kaneko, MD, PhD, Assistant Professor, Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine; K. Yamaoka, MD, PhD, Associate Professor, Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine; T. Takeuchi, MD, PhD, Professor, Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine. tsutake@z5.keio.jp.
authors: Tsutomu
authors: T
authors: Takeuchi
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D018501:Antirheumatic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D001172:Arthritis, Rheumatoid / Q000188:drug therapy*; D001688:Biological Products / Q000009:adverse effects* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012042:Registries
chemical_list: D018501:Antirheumatic Agents; D001688:Biological Products
keywords: ADVERSE EVENTS; BIOLOGICAL THERAPY; ELDERLY PATIENT; RHEUMATOID ARTHRITIS; SAFETY