title: A Single Mass Forming Colonic Primary Mantle Cell Lymphoma.
abstract: Mantle cell lymphoma (MCL) is a subtype of non-Hodgkin's lymphoma (NHL) comprising around 7% of adult NHL. It is characterized by a chromosomal translocation t(11:14) and overexpression of Cyclin D1. The incidence of secondary gastrointestinal tract involvement in MCL ranges from 10 to 28% in various series. However primary gastrointestinal MCL is very rare, accounting for only 1 to 4% of primary gastrointestinal lymphomas. The most common endoscopic feature of primary intestinal MCL is multiple lymphomatous polyposis. In rare cases it presents as protruded lesions or superficial lesions. Single colonic mass presentation is an extremely infrequent presentation. MCL has an aggressive course with quick progression, and most cases are discovered in the advanced stages. Colonic biopsies with histologic examination and specific immunohistochemical staining are the gold standard for a proper diagnosis. We report a case of a single mass forming mantle cell lymphoma of the ascending colon in a 57-year-old female patient with unusual colonoscopic and radiologic features and describe the therapy the patient received, thereby adding to the spectrum of clinical presentations of this aggressive lymphoproliferative disorder.
authors: Division of Gastroenterology, Department of Internal Medicine, American University of Beirut Medical Center, P.O. Box 11-0236, Riad El Solh, Beirut 110-72020, Lebanon.
authors: Fady
authors: 0000-0002-7319-1376
authors: F
authors: Daniel
authors: Division of Hematology & Oncology, Department of Internal Medicine, American University of Beirut Medical Center, P.O. Box 11-0236, Riad El Solh, Beirut 110-72020, Lebanon.
authors: Hazem I
authors: HI
authors: Assi
authors: Division of Gastroenterology, Department of Internal Medicine, American University of Beirut Medical Center, P.O. Box 11-0236, Riad El Solh, Beirut 110-72020, Lebanon.
authors: Walid
authors: W
authors: Karaoui
authors: Division of Hematology & Oncology, Department of Internal Medicine, American University of Beirut Medical Center, P.O. Box 11-0236, Riad El Solh, Beirut 110-72020, Lebanon.
authors: Jean
authors: J
authors: El Cheikh
authors: Pathology and Laboratory Medicine Department, American University of Beirut Medical Center, P.O. Box 11-0236, Riad El Solh, Beirut 110-72020, Lebanon.
authors: Sami
authors: S
authors: Bannoura
authors: Pathology and Laboratory Medicine Department, American University of Beirut Medical Center, P.O. Box 11-0236, Riad El Solh, Beirut 110-72020, Lebanon.
authors: Samer
authors: S
authors: Nassif