title: Effect of Coenzyme Q10 on Proteomic Profile of Rat Brain Amygdala during Acute Metabolic Stress.
abstract: Differences in the proteomic profiles of the brain amygdala in rats with different prognostic resistance to stress were found on the model of metabolic stress. Differential expression of tropomodulin-2, GTP-binding protein SAR1, peroxiredoxin-2, calcineurin B homologous protein 1, Ras-related protein Rab-14, glutathione S-transferase omega-1, Tcrb protein, and NADH dehydrogenase [ubiquinone] iron-sulfur protein 8 (mitochondrial) was shown to depend on the behavioral pattern of animals and stage of the study. Specific features were observed in the involvement of the amygdala in the stress response of specimens with various behavioral characteristics.
authors: Research Institute of Nutrition, Russian Academy of Medical Sciences, Moscow, Russia. n.kirbaeva@gmail.com.
authors: N V
authors: NV
authors: Kirbaeva
authors: Research Institute of Nutrition, Russian Academy of Medical Sciences, Moscow, Russia.
authors: N E
authors: NE
authors: Sharanova
authors: Research Institute of Nutrition, Russian Academy of Medical Sciences, Moscow, Russia.
authors: V M
authors: VM
authors: Zhminchenko
authors: Center of Common Use "Human Proteome", V. I. Orekhovich Research Institute of Biomedical Chemistry, Moscow, Russia.
authors: I Yu
authors: IY
authors: Toropygin
authors: P. K. Anokhin Research Institute of Normal Physiology, Moscow, Russia.
authors: E V
authors: EV
authors: Koplik
authors: P. K. Anokhin Research Institute of Normal Physiology, Moscow, Russia.
authors: S S
authors: SS
authors: Pertsov
authors: Research Institute of Nutrition, Russian Academy of Medical Sciences, Moscow, Russia.
authors: A V
authors: AV
authors: Vasil'ev
mesh_terms: D000679:Amygdala / Q000378:metabolism*; D000818:Animals; D002135:Calcium-Binding Proteins / Q000378:metabolism; D005982:Glutathione Transferase / Q000378:metabolism; D008074:Lipoproteins / Q000378:metabolism; D008297:Male; D020559:Monomeric GTP-Binding Proteins / Q000378:metabolism; D018384:Oxidative Stress / Q000187:drug effects; D040901:Proteomics / Q000379:methods*; D051381:Rats; D017208:Rats, Wistar; D013312:Stress, Physiological / Q000187:drug effects; D014335:Tropomyosin / Q000378:metabolism; D014451:Ubiquinone / Q000031:analogs & derivatives* / Q000494:pharmacology
chemical_list: D002135:Calcium-Binding Proteins; D008074:Lipoproteins; D014335:Tropomyosin; C098929:calcium binding protein p22, rat; D014451:Ubiquinone; D005982:Glutathione Transferase; C487879:SAR1 protein, rat; D020559:Monomeric GTP-Binding Proteins; C024989:coenzyme Q10
keywords: amygdala; coenzyme Q10; comparative proteomic study; metabolic stress; rats