title: Abrogation of CC chemokine receptor 9 ameliorates ventricular remodeling in mice after myocardial infarction.
abstract: CC chemokine receptor 9 (CCR9), which is a unique receptor for CC chemokine ligand (CCL25), is mainly expressed on lymphocytes, dendritic cells (DCs) and monocytes/macrophages. CCR9 mediates the chemotaxis of inflammatory cells and participates in the pathological progression of inflammatory diseases. However, the role of CCR9 in the pathological process of myocardial infarction (MI) remains unexplored; inflammation plays a key role in this process. Here, we used CCR9 knockout mice to determine the functional significance of CCR9 in regulating post-MI cardiac remodeling and its underlying mechanism. MI was induced by surgical ligation of the left anterior descending coronary artery in CCR9 knockout mice and their CCR9+/+ littermates. Our results showed that the CCR9 expression levels were up-regulated in the hearts of the MI mice. Abrogation of CCR9 improved the post-MI survival rate and left ventricular (LV) dysfunction and decreased the infarct size. In addition, the CCR9 knockout mice exhibited attenuated inflammation, apoptosis, structural and electrical remodeling compared with the CCR9+/+ MI mice. Mechanistically, CCR9 mainly regulated the pathological response by interfering with the NF-κB and MAPK signaling pathways. In conclusion, the data reveal that CCR9 serves as a novel modulator of pathological progression following MI through NF-κB and MAPK signaling.
authors: Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan 430060, PR China.|Cardiovascular Research Institute, Wuhan University, Wuhan 430060, PR China.|Hubei Key Laboratory of Cardiology, Wuhan 430060, PR China.
authors: Yan
authors: Y
authors: Huang
authors: Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan 430060, PR China.|Cardiovascular Research Institute, Wuhan University, Wuhan 430060, PR China.|Hubei Key Laboratory of Cardiology, Wuhan 430060, PR China.
authors: Dandan
authors: D
authors: Wang
authors: Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan 430060, PR China.
authors: Xin
authors: X
authors: Wang
authors: Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan 430060, PR China.|Cardiovascular Research Institute, Wuhan University, Wuhan 430060, PR China.|Hubei Key Laboratory of Cardiology, Wuhan 430060, PR China.
authors: Yijie
authors: Y
authors: Zhang
authors: Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan 430060, PR China.|Cardiovascular Research Institute, Wuhan University, Wuhan 430060, PR China.|Hubei Key Laboratory of Cardiology, Wuhan 430060, PR China.
authors: Tao
authors: T
authors: Liu
authors: Cardiovascular Research Institute, Wuhan University, Wuhan 430060, PR China.|Hubei Key Laboratory of Cardiology, Wuhan 430060, PR China.
authors: Yuting
authors: Y
authors: Chen
authors: Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan 430060, PR China.|Cardiovascular Research Institute, Wuhan University, Wuhan 430060, PR China.|Hubei Key Laboratory of Cardiology, Wuhan 430060, PR China.
authors: Yanhong
authors: Y
authors: Tang
authors: Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan 430060, PR China.|Cardiovascular Research Institute, Wuhan University, Wuhan 430060, PR China.|Hubei Key Laboratory of Cardiology, Wuhan 430060, PR China.
authors: Teng
authors: T
authors: Wang
authors: Cardiovascular Research Institute, Wuhan University, Wuhan 430060, PR China.|Hubei Key Laboratory of Cardiology, Wuhan 430060, PR China.|Masonic Medical Research Laboratory, Utica, NY, USA.
authors: Dan
authors: D
authors: Hu
authors: Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan 430060, PR China.|Cardiovascular Research Institute, Wuhan University, Wuhan 430060, PR China.|Hubei Key Laboratory of Cardiology, Wuhan 430060, PR China.
authors: Congxin
authors: C
authors: Huang
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D020869:Gene Expression Profiling; D018345:Mice, Knockout; D020929:Mitogen-Activated Protein Kinase Kinases; D009203:Myocardial Infarction / Q000473:pathology*; D016328:NF-kappa B / Q000378:metabolism; D054388:Receptors, CCR / Q000172:deficiency / Q000378:metabolism*; D015398:Signal Transduction; D016019:Survival Analysis; D020257:Ventricular Remodeling
chemical_list: C119309:CC chemokine receptor 9; D016328:NF-kappa B; D054388:Receptors, CCR; D020929:Mitogen-Activated Protein Kinase Kinases