title: Sustained release profile of quatro stimuli nanocontainers as a multi sensitive vehicle exploiting cancer characteristics.
abstract: A versatile drug delivery carrier that responds to external stimuli was synthesized via the emulsion polymerization process. This simple two-step process was carried out by using Poly (Methyl Methacrylate) as a soft template and a series of monomers, with desired properties, as coating monomers. It is noteworthy that during shell fabrication (2nd step) an inner cavity is created inside the nanocontainers that can be used as a host for small drug molecules. The thermo-, pH- and redox sensitive monomers used in the coating procedure were Dimethyl Amino Ethyl Methacrylate (DMAEMA), Acrylic Acid (AA) and N,N'-(disulfanediylbis(ethane-2,1-diyl))bis(2-methylacrylamide) (Disulfide or DS), respectively. It has to be noted that DMAEMA is also pH- sensitive and acts synergistically with AA. The surface of the multi-stimuli nanocontainers was functionalized with magnetite nanoparticles in order to induce an alternating magnetic field (AMF) sensitivity. By using AMF in various strenghts and frequencies, the temperature of the final multi-stimuli nanocontainers (Q-NCs) can be increased in a controlled manner resulting in the Hyperthermia phenomenon. Loading and release studies were carried out using the anthracycline drug, Doxorubicin, aiming at the confirmation of the release mechanism.
authors: Sol-Gel laboratory, Institute of Nanoscience and Nanotechnology, NCSR "Demokritos", 153 10 Aghia Paraskevi Attikis, Greece; Materials Science Department, School of Natural Sciences, University of Patras, 26 500 Patras, Greece.
authors: Christos
authors: C
authors: Tapeinos
authors: Sol-Gel laboratory, Institute of Nanoscience and Nanotechnology, NCSR "Demokritos", 153 10 Aghia Paraskevi Attikis, Greece. Electronic address: e.efthimiadou@inn.demokritos.gr.
authors: Eleni K
authors: EK
authors: Efthimiadou
authors: Sol-Gel laboratory, Institute of Nanoscience and Nanotechnology, NCSR "Demokritos", 153 10 Aghia Paraskevi Attikis, Greece.
authors: Nikos
authors: N
authors: Boukos
authors: Sol-Gel laboratory, Institute of Nanoscience and Nanotechnology, NCSR "Demokritos", 153 10 Aghia Paraskevi Attikis, Greece.
authors: George
authors: G
authors: Kordas
mesh_terms: D006801:Humans; D008855:Microscopy, Electron, Scanning; D049329:Nanostructures; D009369:Neoplasms / Q000503:physiopathology*; D013059:Spectrum Analysis, Raman
keywords: (99m)Tc; Biodistribution; Hollow nanocontainers; Magnetic nanoparticles; Quatro-stimuli; Radiolabelling; Redox-sensitive; Stimuli responsive; Thermo-sensitive; in vivo imaging; pH-sensitive