title: A Korean patient with Guillain-Barré syndrome following acute hepatitis E whose cholestasis resolved with steroid therapy.
abstract: Autochthonous hepatitis E virus (HEV) is an emerging pathogen in developed countries, and several cases of acute HEV infection have been reported in South Korea. However, there have been no reports on HEV-associated Guillain-Barré syndrome (GBS) in Korea. We recently experienced the case of a 58-year-old Korean male with acute HEV infection after ingesting raw deer meat. Persistent cholestasis was resolved by the administration of prednisolone. At 2.5 months after the clinical presentation of HEV infection, the patient developed weakness of the lower limbs, and was diagnosed with GBS associated with acute hepatitis E. To our knowledge, this is the second report on supportive steroid therapy for persistent cholestasis due to hepatitis E, and the first report of GBS in a Korean patient with acute HEV infection.
authors: Department of Internal Medicine, Gyeongsang National University Hospital, Gyeongsang National University School of Medicine, Jinju, Korea.
authors: Sung Bok
authors: SB
authors: Ji
authors: Department of Internal Medicine, Gyeongsang National University Hospital, Gyeongsang National University School of Medicine, Jinju, Korea.
authors: Sang Soo
authors: SS
authors: Lee
authors: Department of Internal Medicine, Gyeongsang National University Hospital, Gyeongsang National University School of Medicine, Jinju, Korea.
authors: Hee Cheul
authors: HC
authors: Jung
authors: Department of Internal Medicine, Gyeongsang National University Hospital, Gyeongsang National University School of Medicine, Jinju, Korea.
authors: Hong Jun
authors: HJ
authors: Kim
authors: Department of Internal Medicine, Gyeongsang National University Hospital, Gyeongsang National University School of Medicine, Jinju, Korea.
authors: Hyun Jin
authors: HJ
authors: Kim
authors: Department of Internal Medicine, Gyeongsang National University Hospital, Gyeongsang National University School of Medicine, Jinju, Korea.
authors: Tae Hyo
authors: TH
authors: Kim
authors: Department of Internal Medicine, Gyeongsang National University Hospital, Gyeongsang National University School of Medicine, Jinju, Korea.
authors: Woon Tae
authors: WT
authors: Jung
authors: Department of Internal Medicine, Gyeongsang National University Hospital, Gyeongsang National University School of Medicine, Jinju, Korea.
authors: Ok Jae
authors: OJ
authors: Lee
authors: Department of Pathology, Gyeongsang National University Hospital, Gyeongsang National University School of Medicine, Jinju, Korea.
authors: Dae Hyun
authors: DH
authors: Song
mesh_terms: D000208:Acute Disease; D000410:Alanine Transaminase / Q000097:blood; D000914:Antibodies, Viral / Q000097:blood; D001219:Aspartate Aminotransferases / Q000097:blood; D001663:Bilirubin / Q000032:analysis; D002779:Cholestasis / Q000188:drug therapy*; D020275:Guillain-Barre Syndrome / Q000150:complications / Q000175:diagnosis*; D016751:Hepatitis E / Q000175:diagnosis* / Q000209:etiology; D016752:Hepatitis E virus / Q000276:immunology; D006801:Humans; D007075:Immunoglobulin M / Q000097:blood; D008099:Liver / Q000473:pathology; D008297:Male; D008875:Middle Aged; D011239:Prednisolone / Q000627:therapeutic use; D056910:Republic of Korea; D013256:Steroids / Q000627:therapeutic use*
chemical_list: D000914:Antibodies, Viral; D007075:Immunoglobulin M; D013256:Steroids; D011239:Prednisolone; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D001663:Bilirubin
keywords: Guillain-Barré syndrome; Hepatitis E; Jaundice; Steroid treatment