title: Comparison of lung damage in mice exposed to black carbon particles and ozone-oxidized black carbon particles.
abstract: Black carbon (BC) is a key component of atmospheric particles and has a significant effect on human health. Oxidation could change the characteristics of BC and increase its toxicity. The comparison of lung damage in mice exposed to BC and ozone-oxidized BC (oBC) particles is investigated in this study. Mice which were intratracheally instilled with particles have a higher expression of IL-1β, IL-6 and IL-33 in bronchoalveolar lavage fluid (BALF). Also, the IL-6, IL-33 mRNA expression in the lung tissue of mice instilled with oBC was higher than that of mice instilled with BC. The expression of CD3 in the lung tissue of mice intratracheally instilled with oBC was higher than the mice distilled with BC. The pathology results showed that the lung tissue of mice instilled with oBC particles have much more inflammatory cells infiltration than that of mice treated with BC. It is believed that the PI3K-AKT pathway might be involved in the oBC particles caused lung damage. Results indicated that oBC particles in the atmosphere may cause more damage to health.
authors: Department of Toxicology, School of Public Health, Peking University, Beijing 100191, PR China; Beijing Key Laboratory of Toxicological Research and Risk Assessment for Food Safety, Beijing 100191, PR China.
authors: Hongqian
authors: H
authors: Chu
authors: State Key Joint Laboratory of Environmental Simulation and Pollution Control, College of Environmental Sciences and Engineering, Peking University, Beijing 100871, PR China.
authors: Jing
authors: J
authors: Shang
authors: Department of Toxicology, School of Public Health, Peking University, Beijing 100191, PR China; Beijing Key Laboratory of Toxicological Research and Risk Assessment for Food Safety, Beijing 100191, PR China.
authors: Ming
authors: M
authors: Jin
authors: State Key Joint Laboratory of Environmental Simulation and Pollution Control, College of Environmental Sciences and Engineering, Peking University, Beijing 100871, PR China; POTEN Environment Group Co., Ltd., Beijing 100082, PR China.
authors: Qian
authors: Q
authors: Li
authors: State Key Joint Laboratory of Environmental Simulation and Pollution Control, College of Environmental Sciences and Engineering, Peking University, Beijing 100871, PR China.
authors: Yueyue
authors: Y
authors: Chen
authors: Department of Toxicology, School of Public Health, Peking University, Beijing 100191, PR China; Beijing Key Laboratory of Toxicological Research and Risk Assessment for Food Safety, Beijing 100191, PR China.
authors: Hongpeng
authors: H
authors: Huang
authors: Department of Toxicology, School of Public Health, Peking University, Beijing 100191, PR China; Beijing Key Laboratory of Toxicological Research and Risk Assessment for Food Safety, Beijing 100191, PR China.
authors: Yuan
authors: Y
authors: Li
authors: Department of Toxicology, School of Public Health, Peking University, Beijing 100191, PR China; Beijing Key Laboratory of Toxicological Research and Risk Assessment for Food Safety, Beijing 100191, PR China.
authors: Yao
authors: Y
authors: Pan
authors: Department of Toxicology, School of Public Health, Peking University, Beijing 100191, PR China; Beijing Key Laboratory of Toxicological Research and Risk Assessment for Food Safety, Beijing 100191, PR China.
authors: Xi
authors: X
authors: Tao
authors: Department of Toxicology, School of Public Health, Peking University, Beijing 100191, PR China; Beijing Key Laboratory of Toxicological Research and Risk Assessment for Food Safety, Beijing 100191, PR China.
authors: Zhiyuan
authors: Z
authors: Cheng
authors: Department of Toxicology, School of Public Health, Peking University, Beijing 100191, PR China; Beijing Key Laboratory of Toxicological Research and Risk Assessment for Food Safety, Beijing 100191, PR China.
authors: Qinghe
authors: Q
authors: Meng
authors: Department of Occupational and Environmental Health Sciences, School of Public Health, Peking University, Beijing 100191, PR China.
authors: Guang
authors: G
authors: Jia
authors: State Key Joint Laboratory of Environmental Simulation and Pollution Control, College of Environmental Sciences and Engineering, Peking University, Beijing 100871, PR China.
authors: Tong
authors: T
authors: Zhu
authors: Department of Toxicology, School of Public Health, Peking University, Beijing 100191, PR China; Beijing Key Laboratory of Toxicological Research and Risk Assessment for Food Safety, Beijing 100191, PR China. Electronic address: weixt1010@gmail.com.
authors: Xuetao
authors: X
authors: Wei
authors: Department of Toxicology, School of Public Health, Peking University, Beijing 100191, PR China; Beijing Key Laboratory of Toxicological Research and Risk Assessment for Food Safety, Beijing 100191, PR China. Electronic address: whao@bjmu.edu.cn.
authors: Weidong
authors: W
authors: Hao
mesh_terms: D000818:Animals; D001992:Bronchoalveolar Lavage Fluid / Q000737:chemistry / Q000276:immunology; D005260:Female; D019570:Inhalation Exposure / Q000009:adverse effects*; D008168:Lung / Q000187:drug effects* / Q000276:immunology / Q000473:pathology; D008810:Mice, Inbred C57BL; D010084:Oxidation-Reduction; D010126:Ozone / Q000737:chemistry*; D052638:Particulate Matter / Q000737:chemistry / Q000633:toxicity*; D053260:Soot / Q000737:chemistry / Q000633:toxicity*
chemical_list: D052638:Particulate Matter; D053260:Soot; D010126:Ozone
keywords: Black carbon; Il-33; Lung; oBC