title: Extremity Soft Tissue Sarcoma: Tailoring Resection to Histologic Subtype.
abstract: Soft tissue sarcomas comprise tumors originating from mesenchymal or connective tissue. Histologic grade is integral to prognosis. Because sarcoma management is multimodal, histologic subtype should inform optimum treatment. Appropriate biopsy and communication between surgeon and pathologist can help ensure a correct diagnosis. Treatment often involves surgical excision with wide margins and adjuvant radiotherapy. There is no consensus on what constitutes an adequate margin for histologic subtypes. An appreciation of how histology corresponds with tumor biology and surgical anatomic constraints is needed for management of this disease. Even with the surgical goal of wide resection being obtained, many patients do not outlive their disease.
authors: Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA.
authors: Matthew G
authors: MG
authors: Cable
authors: Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA. Electronic address: lor.randall@hci.utah.edu.
authors: R Lor
authors: RL
authors: Randall
mesh_terms: D003131:Combined Modality Therapy / Q000379:methods; D005121:Extremities; D006801:Humans; D009364:Neoplasm Recurrence, Local / Q000517:prevention & control*; D011379:Prognosis; D018714:Radiotherapy, Adjuvant; D012509:Sarcoma / Q000473:pathology / Q000532:radiotherapy* / Q000601:surgery*; D012983:Soft Tissue Neoplasms / Q000473:pathology / Q000532:radiotherapy* / Q000601:surgery*; D016896:Treatment Outcome
keywords: Extremity sarcoma; Histologic grade; Representative biopsy; Resection margin; Sarcoma subtypes