title: Experimental Aortic Valve Cusp Extension with CorMatrix in a Porcine Model.
abstract: BackgroundWe tested the feasibility of using porcine small intestinal submucosal extracellular matrix (CorMatrix) for aortic valve (AV) repair in porcine model examining its resorption and remodeling potential.MethodsThe non-coronary cusp was replaced with CorMatrix in four animals for 120 days. Valve function was assessed by echocardiography. Explants were examined by histology, immunohistochemistry, and collagen assessment.ResultsCorMatrix was almost totally replaced with tissue resembling the native cusp with a partial two-layer architecture. However, function was lost due to thickening and calcification.ConclusionsTested in high-pressure AV position in a pig model, CorMatrix degrades and remodels, but also loses function.
authors: Department of Cardiovascular and Thoracic Surgery, Université Catholique de Louvain, Cliniques Universitaire Saint Luc, Brussels, Belgium.
authors: Zahra
authors: Z
authors: Mosala Nezhad
authors: Department of Cardiovascular and Thoracic Surgery, Université Catholique de Louvain, Cliniques Universitaire Saint Luc, Brussels, Belgium.
authors: Alain
authors: A
authors: Poncelet
authors: Laboratory of Anatomy Pathology, Université Catholique de Louvain, Mont-Godinne Hospital-CHU, Mont-Godinne, Belgium.
authors: Caroline
authors: C
authors: Fervaille
authors: Department of Cardiovascular and Thoracic Surgery, Université Catholique de Louvain, Cliniques Universitaire Saint Luc, Brussels, Belgium.
authors: Laurent
authors: L
authors: de Kerchove
authors: Division of Experimental Surgery and Transplantation (CHEX), Institute of Experimental and Clinical Research (IREC), Université Catholque de Louvain, Brussels, Belgium.
authors: Pierre
authors: P
authors: Gianello
mesh_terms: D020341:Absorbable Implants; D000818:Animals; D001021:Aortic Valve / Q000000981:diagnostic imaging / Q000473:pathology / Q000503:physiopathology / Q000601:surgery*; D001706:Biopsy; D002114:Calcinosis / Q000209:etiology / Q000473:pathology / Q000503:physiopathology; D006348:Cardiac Surgical Procedures / Q000009:adverse effects / Q000295:instrumentation*; D003094:Collagen / Q000378:metabolism; D004452:Echocardiography; D005109:Extracellular Matrix / Q000473:pathology / Q000637:transplantation*; D005240:Feasibility Studies; D007150:Immunohistochemistry; D023421:Models, Animal; D034421:Sus scrofa; D013997:Time Factors
chemical_list: D003094:Collagen