title: Population-Stratified Analysis of Bone Mineral Density Distribution in Cervical and Lumbar Vertebrae of Chinese from Quantitative Computed Tomography.
abstract: To investigate the bone mineral density (BMD) of cervical vertebrae in a population-stratified manner and correlate with that of the lumbar vertebrae.
  
  
  
  Five hundred and ninety-eight healthy volunteers (254 males, 344 females), ranging from 20 to 64 years of age, were recruited for volumetric BMD (vBMD) measurements by quantitative computed tomography. Basic information (age, height, weight, waistline, and hipline), and vBMD of the cervical and lumbar vertebrae (C2-7 and L2-4) were recorded. Comparisons among sex, age groups and different levels of vertebrae were analyzed using analysis of variance. Linear regression was performed for relevance of different vertebral levels.
  
  
  
  The vBMD of cervical and lumbar vertebrae was higher in females than males in each age group. The vBMD of the cervical and lumbar vertebrae in males and the vBMD of lumbar vertebrae in females decreased with aging. In each age group, the vBMD of the cervical vertebrae was higher than that of the lumbar vertebrae with gradual decreases from C2 to C7 except for C3; moreover, the vBMD of C6 and C7 was significantly different from that of C2-5. Correlations of vBMD among different cervical vertebrae (females: r = 0.62-0.94; males: r = 0.63-0.94) and lumbar vertebrae (males: r = 0.93-0.98; females: r = 0.82-0.97) were statistically significant at each age group.
  
  
  
  The present study provided normative data of cervical vertebrae in an age- and sex-stratified manner. Sex differences in vBMD prominently vary with age, which can be helpful to design a more comprehensive pre-operative surgical plan.
authors: Department of Radiology, The Fourth Clinical Medical College of Peking University, Beijing Jishuitan Hospital, Beijing 100035, China.
authors: Yong
authors: Y
authors: Zhang
authors: Department of Orthopedic Oncology, The Third Hospital of Hebei Medical University, Shijiazhuang 050051, China.
authors: Zhuang
authors: Z
authors: Zhou
authors: Beijing Institute of Traumatology and Orthopedics, Beijing 100035, China.
authors: Cheng'ai
authors: C
authors: Wu
authors: Beijing Institute of Traumatology and Orthopedics, Beijing 100035, China.
authors: Danhui
authors: D
authors: Zhao
authors: Beijing Institute of Traumatology and Orthopedics, Beijing 100035, China.
authors: Chao
authors: C
authors: Wang
authors: Department of Radiology, The Fourth Clinical Medical College of Peking University, Beijing Jishuitan Hospital, Beijing 100035, China.
authors: Xiaoguang
authors: X
authors: Cheng
authors: Department of Radiology, The Fourth Clinical Medical College of Peking University, Beijing Jishuitan Hospital, Beijing 100035, China.
authors: Wei
authors: W
authors: Cai
authors: Department of Radiology, The Fourth Clinical Medical College of Peking University, Beijing Jishuitan Hospital, Beijing 100035, China.
authors: Ling
authors: L
authors: Wang
authors: Department of Radiology, The Fourth Clinical Medical College of Peking University, Beijing Jishuitan Hospital, Beijing 100035, China.
authors: Yangyang
authors: Y
authors: Duanmu
authors: Department of Radiology, The Fourth Clinical Medical College of Peking University, Beijing Jishuitan Hospital, Beijing 100035, China.
authors: Chenxin
authors: C
authors: Zhang
authors: Department of Spine Surgery, The Fourth Clinical Medical College of Peking University, Beijing Jishuitan Hospital, Beijing 100035, China.
authors: Wei
authors: W
authors: Tian
mesh_terms: D000328:Adult; D000375:Aging / Q000208:ethnology / Q000502:physiology; D000886:Anthropometry / Q000379:methods; D044466:Asian People / Q000706:statistics & numerical data; D015519:Bone Density / Q000502:physiology*; D002574:Cervical Vertebrae / Q000000981:diagnostic imaging / Q000502:physiology*; D005260:Female; D006801:Humans; D016014:Linear Models; D008159:Lumbar Vertebrae / Q000000981:diagnostic imaging / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D012016:Reference Values; D012727:Sex Characteristics; D014057:Tomography, X-Ray Computed / Q000379:methods; D055815:Young Adult
keywords: Bone density; Cervical; Computed tomography; Lumbar; Normal; Population; Quantitative; Vertebra