title: Predicting Donor Death: Early Changes in Oxygen Saturation After Withdrawal of Support Predict Successful Donation During Donation After Circulatory Death.
abstract: BACKGROUND
  We have previously shown that approximately 27% of patients do not progress to death in time to donate organs after attempted donation after circulatory death (DCD). As such, nearly 1000 transplants per year are not possible. One way to convert unsuccessful donations to successful donations is to increase procurement team "stand-down" times; however, increased stand-down times may predispose transplantable organs to increased ischemic damage.
  
  
  METHODS
  Hemodynamics for successful and unsuccessful donations, occurring between 2011 and 2014, were characterized to determine if some unsuccessful DCDs could have donated successfully, had procurement teams waited longer.
  
  
  RESULTS
  Analysis of 169 DCDs demonstrated statistically significant differences in hemodynamic profiles after withdrawal of support (WOS) between successful and unsuccessful donations. Early decreases in oxygen saturation were predictive of successful organ donation. We observed that for unsuccessful DCDs, patients who died in more than 2 hours but less than 12 hours were agonal within 10 minutes of WOS, suggesting that increasing stand-down times would result in prohibitive warm ischemia time.
  
  
  CONCLUSIONS
  Early changes in oxygen saturation after withdrawal of support predict donor death. Alternative approaches that convert unsuccessful DCDs to successful DCDs but that do not result in low-quality organs should be explored.
authors: Department of Surgery, Division of Transplantation, University of Wisconsin, Madison, Wisconsin. Electronic address: scalea@surgery.wisc.edu.
authors: J R
authors: JR
authors: Scalea
authors: Department of Surgery, Division of Transplantation, University of Wisconsin, Madison, Wisconsin.
authors: A M
authors: AM
authors: D'Alessandro
authors: Department of Surgery, Division of Transplantation, University of Wisconsin, Madison, Wisconsin.
authors: L A
authors: LA
authors: Fernandez
mesh_terms: D000328:Adult; D003643:Death; D005260:Female; D006439:Hemodynamics / Q000502:physiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D010100:Oxygen / Q000097:blood; D014019:Tissue Donors; D009927:Tissue and Organ Procurement / Q000379:methods*; D019737:Transplants / Q000098:blood supply*; D052096:Warm Ischemia
chemical_list: D010100:Oxygen