title: Genetic variance of transforming growth factor β2 gene in conotruncal heart defects.
abstract: OBJECTIVE
  The aim of this study was to evaluate the association between two haplotype-tag single nucleotide polymorphisms (SNPs) (rs6658835 and rs10495098) of TGF-β2 and conotruncal heart defects (CTDs).
  
  
  METHODS
  Two polymorphisms of TGF-β2 gene were genotyped by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) from 259 CTDs patients and 310 control subjects.
  
  
  RESULTS
  The association between SNP rs6658835 in TGF-β2 and CTDs has been found. The frequency of G allele in CTDs patients was significantly higher than that in control subjects (52.7% versus 40.3%, p < 0.001, OR =1.649).
  
  
  CONCLUSIONS
  TGF-β2 gene polymorphisms may serve as a novel genetic marker for the risk of CTDs.
authors: a Department of Cardiology , Sichuan Academy of Medical Sciences, Sichuan Provincial People's Hospital , Chengdu , China.|b Department of Cardiology , Hospital of the University of Electronic Science and Technology of China , Chengdu , China.
authors: Yu
authors: Y
authors: Chen
authors: c Department of Cardiovascular Surgery , West China Hospital of Sichuan University , Chengdu , China.|d Department of Cardiovascular Surgery , The Seventh People's Hospital of Chengdu , Chengdu , China.
authors: Rui
authors: R
authors: Zhang
authors: e Department of Cardiology , West China Hospital of Sichuan University , Chengdu , China.
authors: Jun
authors: J
authors: Xie
authors: e Department of Cardiology , West China Hospital of Sichuan University , Chengdu , China.
authors: Yajiao
authors: Y
authors: Li
authors: f Department of Immunology , West China School of Preclinical and Forensic Medicine, Sichuan University , Chengdu , China.
authors: Shaoqing
authors: S
authors: Shi
authors: c Department of Cardiovascular Surgery , West China Hospital of Sichuan University , Chengdu , China.
authors: Hong
authors: H
authors: Qian
authors: g Department of Cardiovascular Surgery Center , Beijing An-Zhen Hospital, Capital Medical University , Beijing , China.
authors: Zhiguo
authors: Z
authors: Yan
authors: e Department of Cardiology , West China Hospital of Sichuan University , Chengdu , China.
authors: Li
authors: L
authors: Rao
mesh_terms: D016022:Case-Control Studies; D002675:Child, Preschool; D005260:Female; D005787:Gene Frequency; D014644:Genetic Variation; D005838:Genotype; D006330:Heart Defects, Congenital / Q000235:genetics*; D006801:Humans; D008297:Male; D020641:Polymorphism, Single Nucleotide; D053781:Transforming Growth Factor beta2 / Q000235:genetics*
chemical_list: C509041:TGFB2 protein, human; D053781:Transforming Growth Factor beta2
keywords: Conotruncal heart defects; single nucleotide polymorphisms; transforming growth factor β2