title: Adolescent Predictors of a Typology of DSM-5 Alcohol Use Disorder Symptoms in Young Adults Derived by Latent Class Analysis Using Data From an Australian Cohort Study.
abstract: There is little research examining alcohol use disorder (AUD) symptoms (based on criteria from the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition [DSM-5]) in young adulthood. We assessed symptom structure at 24 years using latent class analysis (LCA), examining relationships between class membership and (a) concurrent alcohol use and DSM-5 AUD severity and (b) adolescent risk factors.
  
  
  
  A stratified, random sample of 1,943 adolescents ages 14-15 years was recruited from 44 secondary schools in Victoria, Australia, and interviewed during adolescence and young adulthood. We report findings on drinkers who completed the AUD module (N = 1,268; 51% male).
  
  
  
  Data clearly fit a three-class, dimensional model, comprising "mild symptoms" (63.2%), "moderate symptoms" (32.2%), and "severe symptoms" (4.6%) classes. Class membership was validated by concurrent drinking patterns and in reasonable agreement with DSM-5 AUD severity categories. Relative to mild symptoms class membership, moderate symptoms class membership increased odds of adolescent alcohol problems (odds ratio [OR] = 2.0, 95% CI [1.2, 3.5]) and persisting anxiety/depression symptoms (OR = 1.9, 95% CI [1.2, 3.1]). Daily smoking (OR = 2.6, 95% CI [1.1, 5.9]), persisting anxiety/ depression symptoms (OR = 2.5, 95% CI [1.3, 5.0]), and antisocial behavior (OR = 3.2, 95% CI [1.5, 6.8]) increased odds of severe symptoms class membership. Adolescent daily smoking (OR = 0.3, 95% CI [0.11, 0.81]) and antisocial behavior (OR = 0.3, 95% CI [0.14, 0.64]) were less likely among members of the moderate symptoms class, relative to the severe symptoms class.
  
  
  
  We found support for a dimensional AUD typology like that in DSM-5. Young adults with more severe AUD symptoms had a different adolescent risk profile than those in the low and moderate classes. These findings provide a focus for preventive intervention in adolescence to limit the severity of AUDs in young adulthood.
authors: National Drug and Alcohol Research Centre, The University of New South Wales (UNSW) Australia, Sydney, New South Wales, Australia.|National Health & Medical Research Council (NHMRC) Centre of Research Excellence in Mental Health and Substance Use, National Drug and Alcohol Research Centre, UNSW Australia, Sydney, New South Wales, Australia.
authors: Wendy
authors: W
authors: Swift
authors: National Drug and Alcohol Research Centre, The University of New South Wales (UNSW) Australia, Sydney, New South Wales, Australia.|National Health & Medical Research Council (NHMRC) Centre of Research Excellence in Mental Health and Substance Use, National Drug and Alcohol Research Centre, UNSW Australia, Sydney, New South Wales, Australia.
authors: Tim
authors: T
authors: Slade
authors: National Drug and Alcohol Research Centre, The University of New South Wales (UNSW) Australia, Sydney, New South Wales, Australia.|National Health & Medical Research Council (NHMRC) Centre of Research Excellence in Mental Health and Substance Use, National Drug and Alcohol Research Centre, UNSW Australia, Sydney, New South Wales, Australia.|Office of Medical Education, UNSW Australia, Sydney, New South Wales, Australia.
authors: Natacha
authors: N
authors: Carragher
authors: Centre for Adolescent Health, Murdoch Children's Research Institute, Parkville, Victoria, Australia.
authors: Carolyn
authors: C
authors: Coffey
authors: National Drug and Alcohol Research Centre, The University of New South Wales (UNSW) Australia, Sydney, New South Wales, Australia.|Centre for Adolescent Health, Murdoch Children's Research Institute, Parkville, Victoria, Australia.|School of Population and Global Health, University of Melbourne, Parkville, Victoria, Australia.|Department of Global Health, School of Public Health, University of Washington, Seattle, Washington, United States.
authors: Louisa
authors: L
authors: Degenhardt
authors: Centre for Youth Substance Abuse Research, University of Queensland, St. Lucia, Queensland, Australia.|Institute of Psychiatry, King's College London, London, England.
authors: Wayne
authors: W
authors: Hall
authors: Centre for Adolescent Health, Murdoch Children's Research Institute, Parkville, Victoria, Australia.|Department of Pediatrics, University of Melbourne, Parkville, Victoria, Australia.
authors: George
authors: G
authors: Patton
mesh_terms: D000293:Adolescent; D000294:Adolescent Behavior; D000328:Adult; D019973:Alcohol-Related Disorders / Q000175:diagnosis / Q000523:psychology*; D015331:Cohort Studies; D039721:Diagnostic and Statistical Manual of Mental Disorders; D005260:Female; D006801:Humans; D008297:Male; D012307:Risk Factors; D012574:Schools; D012720:Severity of Illness Index; D014739:Victoria; D055815:Young Adult