title: Factors related to completeness of medical abortion with mifepristone and misoprostol.
abstract: BACKGROUND
  Medical abortion that occurs in early pregnancy is generally safe and successful, but incomplete medical abortion can result in complications. This study aimed to examine factors related to completeness of medical abortion with mifepristone and misoprostol, and then to provide a new direction for research into establishing complete abortion with mifepristone and misoprostol.
  
  
  METHODS
  Sixty-three patients with early pregnancy requesting medical abortion with mifepristone and misoprostol were selected. Immunohistochemistry was used to detect the expression and location of progesterone receptor, estrogen receptor, insulin-like growth factor-1, and vascular endothelial growth factor in chorionic villi among these women. Reverse transcriptase polymerase chain reaction was then used to determine the expression of insulin-like growth factor-1 and vascular endothelial growth factor mRNA.
  
  
  RESULTS
  According to the outcome of medical abortion, the women were divided into either the incomplete medical abortion group (n=34) or the complete medical abortion group (n=29). Immunohistochemical analysis showed that progesterone receptor and estrogen receptor protein expression was not detected in chorionic villi in the two groups. However, compared with the complete abortion group, there was a marked decrease in the expression of insulin-like growth factor-1 and a significant increase in the expression of vascular endothelial growth factor (p<0.05) in the incomplete abortion group. There was no significant difference in mRNA expression between the incomplete and complete abortion groups.
  
  
  CONCLUSIONS
  The expression of insulin-like growth factor 1 protein and vascular endothelial growth factor protein in chorionic villi may be related to the outcome of medical abortion with mifepristone and misoprostol.
authors: Department of Obstetrics and Gynecology, The Second Affiliated Hospital of Wenzhou Medical University, Zhejiang, China.
authors: Wen-Xiao
authors: WX
authors: Jiang
authors: Department of Obstetrics and Gynecology, The Second Affiliated Hospital of Wenzhou Medical University, Zhejiang, China.
authors: Fang-Fang
authors: FF
authors: He
authors: Department of Obstetrics and Gynecology, The Second Affiliated Hospital of Wenzhou Medical University, Zhejiang, China.
authors: Qi
authors: Q
authors: Shen
authors: Department of Obstetrics and Gynecology, The Second Affiliated Hospital of Wenzhou Medical University, Zhejiang, China.
authors: Xue-Jiao
authors: XJ
authors: Tao
authors: Department of Obstetrics and Gynecology, The Second Affiliated Hospital of Wenzhou Medical University, Zhejiang, China.
authors: Chu-Chu
authors: CC
authors: Zhao
authors: Department of Obstetrics and Gynecology, The Second Affiliated Hospital of Wenzhou Medical University, Zhejiang, China.
authors: Zhao-Jun
authors: ZJ
authors: Shen
authors: Department of Obstetrics and Gynecology, The Second Affiliated Hospital of Wenzhou Medical University, Zhejiang, China. Electronic address: zjwzzxq@163.com.
authors: Xue-Qiong
authors: XQ
authors: Zhu
mesh_terms: D000028:Abortion, Induced / Q000379:methods*; D000293:Adolescent; D000328:Adult; D005260:Female; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000032:analysis / Q000235:genetics; D015735:Mifepristone / Q000494:pharmacology*; D016595:Misoprostol / Q000494:pharmacology*; D011247:Pregnancy; D012333:RNA, Messenger / Q000032:analysis; D011960:Receptors, Estrogen / Q000032:analysis; D042461:Vascular Endothelial Growth Factor A / Q000032:analysis / Q000235:genetics; D055815:Young Adult
chemical_list: D012333:RNA, Messenger; D011960:Receptors, Estrogen; D042461:Vascular Endothelial Growth Factor A; D016595:Misoprostol; D015735:Mifepristone; D007334:Insulin-Like Growth Factor I
keywords: estrogen receptor; insulin-like growth factor 1; medical abortion; progesterone receptor; vascular endothelial growth factor