title: The prevalence of carotid plaque with different stability and its association with metabolic syndrome in China: The Asymptomatic Polyvascular Abnormalities Community study.
abstract: Few studies have investigated the prevalence of carotid plaque with different stability in Chinese. As is well known, carotid atherosclerosis is tightly associated with metabolic syndrome (MetS); however, the data about the association between the presence of carotid plaque with different stability and MetS was limited. The aim of our study was to investigate the prevalence of carotid plaque with different stability and its potential association with MetS in general Chinese population.The Asymptomatic Polyvascular Abnormalities Community study is a community-based study to investigate the epidemiology of asymptomatic polyvascular abnormalities in Chinese adults. A total of 5393 participants were finally eligible and included in this study. The carotid plaque and its stability were assessed using ultrasonography. The MetS was defined using the criteria from US National Cholesterol Education Program-Adult Treatment Panel III. Data were analyzed with multivariate logistic regression models.Of the 5393 subjects, 1397 (25.9%) participants had stable carotid plaque, 1518 (28.1%) had unstable carotid plaque in participants, and 1456 (27.0%) had a MetS. MetS was, respectively, significantly associated with the prevalence of carotid plaque (odds ratio [OR]: 1.25; 95% confidence interval [CI]: 1.07, 1.47), stable carotid plaque (OR: 1.23; 95% CI: 1.02,1.48), and unstable carotid plaque (OR: 1.27; 95% CI: 1.03,1.56) after adjusting for age, gender, level of education, income, smoking, drinking, physical activity, body mass index, low-density lipoprotein, and high-sensitivity C-reactive protein. With the number of MetS components, the prevalence of carotid plaque, stable carotid plaque, and unstable carotid plaque significantly increased (P for trend <0.0001), respectively.In summary, the prevalence of carotid plaque was 54.1%, stable carotid plaque was 25.9%, and unstable carotid plaque was 28.1%. Our study revealed that the prevalence of carotid plaque, stable carotid plaque, and unstable carotid plaque was, respectively, significantly associated with MetS in the general population.
authors: Department of Epidemiology and Health Statistics, School of Public Health, Capital Medical University Department of Neurology, Beijing Tiantan Hospital, Capital Medical University China National Clinical Research Center for Neurological Diseases Center of Stroke, Beijing Institute for Brain Disorders Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing North China University of Science and Technology Department of Cardiology, Tangshan People's Hospital, North China University of Science and Technology, Tangshan Department of Epidemiology and Health Statistics, Academy of Public Health and Management, Weifang Medical University, Weifang Beijing Municipal Key Laboratory of Clinical Epidemiology, Capital Medical University, Beijing Department of Neurology, Tangshan Gongren Hospital Department of Cardiology, Kailuan Hospital, North China University of Science and Technology, Tangshan, China.
authors: Anxin
authors: A
authors: Wang
authors: Lingyun
authors: L
authors: Wu
authors: Xiaoxue
authors: X
authors: Liu
authors: Zhaoping
authors: Z
authors: Su
authors: Yanxia
authors: Y
authors: Luo
authors: Shuohua
authors: S
authors: Chen
authors: Haibin
authors: H
authors: Li
authors: Xiangtong
authors: X
authors: Liu
authors: Lixin
authors: L
authors: Tao
authors: Jin
authors: J
authors: Guo
authors: Feng
authors: F
authors: Zhang
authors: Yibin
authors: Y
authors: Cao
authors: Xingquan
authors: X
authors: Zhao
authors: Shouling
authors: S
authors: Wu
authors: Xiuhua
authors: X
authors: Guo
mesh_terms: D000328:Adult; D000368:Aged; D059168:Carotid Intima-Media Thickness; D016893:Carotid Stenosis / Q000000981:diagnostic imaging / Q000453:epidemiology*; D002681:China / Q000453:epidemiology; D005260:Female; D006801:Humans; D008297:Male; D024821:Metabolic Syndrome / Q000453:epidemiology*; D008875:Middle Aged; D058226:Plaque, Atherosclerotic / Q000000981:diagnostic imaging / Q000453:epidemiology*; D015995:Prevalence