title: Age-Related Changes in the Cardiometabolic Profiles in Singapore Resident Adult Population: Findings from the National Health Survey 2010.
abstract: We describe the centile trends of the blood pressure, glycemia and lipid profiles as well as renal function of a representative population who participated in the Singapore National Health Survey in 2010. Representative survey population was sampled in two phases, first using geographical/ residential dwelling type stratification, followed up ethnicity. 2,407 survey participants without any self-reported medical or medication history for diabetes mellitus, hypertension and dyslipidemia were included in this analysis. All biochemistry analyses were performed on Roche platforms. After excluding outliers using Tukey's criteria, the results of the remaining participants were subjected to lambda-mu-sigma (LMS) analysis. In men, systolic blood pressure increased linearly with age. By contrast, an upward inflection around late 40s was seen in women. The diastolic blood pressure was highest in men in the late 30s-50s age group, and in women in the late 50s-60s age group. All glycemia-related parameters, i.e. fasting and 2-hour plasma glucose and HbA1c concentrations increased with age, although the rate of increase differed between the tests. Total cholesterol and LDL-cholesterol concentrations increased with age, which became attenuated between the early 30s and late 50s in men, and declined thereafter. In women, total cholesterol and LDL-cholesterol concentrations gradually increased with age until late 30s, when there is an upward inflection, plateauing after late 50s. Our findings indicate that diagnostic performance of laboratory tests for diabetes may be age-sensitive. Unfavourable age-related cardiovascular risk profiles suggest that the burden of cardiovascular disease in this population will increase with aging population.
authors: Department of Laboratory Medicine, National University Hospital, 5 Lower Kent Ridge Road, 119074 Singapore.|Epidemiology & Disease Control Division, Ministry of Health, 16 College Road, 169854 Singapore.
authors: Tze Ping
authors: TP
authors: Loh
authors: Epidemiology & Disease Control Division, Ministry of Health, 16 College Road, 169854 Singapore.
authors: Stefan
authors: S
authors: Ma
authors: Public Health Group, Ministry of Health, 16 College Road, 169854 Singapore.
authors: Derrick
authors: D
authors: Heng
authors: Department of Medicine, National University Hospital, 5 Lower Kent Ridge Road, 119074 Singapore.|Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, 10 Medical Drive, 117597 Singapore.|Cardiovascular and Metabolic Disorders Program, Duke-NUS Graduate Medical School, 8 College Road, 169857 Singapore.
authors: Chin Meng
authors: CM
authors: Khoo
mesh_terms: D000328:Adult; D000367:Age Factors; D001786:Blood Glucose / Q000378:metabolism; D001794:Blood Pressure / Q000502:physiology; D002318:Cardiovascular Diseases / Q000097:blood / Q000453:epidemiology; D002784:Cholesterol / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D005260:Female; D006306:Health Surveys / Q000706:statistics & numerical data*; D006801:Humans; D006973:Hypertension / Q000097:blood; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged; D012846:Singapore / Q000453:epidemiology
chemical_list: D001786:Blood Glucose; D008078:Cholesterol, LDL; D008055:Lipids; D002784:Cholesterol