title: Comparison of the efficacy of icotinib in patients with non-small-cell lung cancer according to the type of epidermal growth factor receptor mutation.
abstract: Icotinib hydrochloride is a novel epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) with preclinical and clinical activity in non-small-cell lung cancer (NSCLC). Exon 19 deletion and L858R point mutation are the most commonly encountered EGFR mutations in NSCLC, and they predict improved clinical outcomes following treatment with icotinib. The objective of this study was to evaluate the differential clinical efficacy of icotinib in patients with exon 19 deletion or L858R point mutation of the EGFR gene. A total of 104 patients with advanced NSCLC, who harbored exon 19 deletion or L858R point mutation of EGFR and were treated with icotinib, were enrolled in this study. The tumor response and progression-free survival were evaluated. There were no significant differences between patients with EGFR exon 19 deletion and those with L858R point mutation who received treatment with icotinib.
authors: Department of Oncology, Qilu Hospital, School of Medicine, Shandong University, Jinan, Shandong 250012, P.R. China.
authors: Zhang Xiao
authors: ZX
authors: Xue
authors: Department of Oncology, Qilu Hospital, School of Medicine, Shandong University, Jinan, Shandong 250012, P.R. China.
authors: Wang Xiu
authors: WX
authors: Wen
authors: Department of Oncology, The Affiliated Hospital of Qingdao University Medical College, Qingdao, Shandong 266003, P.R. China.
authors: Yu
authors: Y
authors: Zhuang
authors: Department of Oncology, Qingdao Hiser Hospital, Qingdao, Shandong 266033, P.R. China.
authors: Zang Jian
authors: ZJ
authors: Hua
authors: Department of Oncology, Qingdao Hiser Hospital, Qingdao, Shandong 266033, P.R. China.
authors: Yang Ni
authors: YN
authors: Xia
keywords: L858R point mutation; epidermal growth factor; exon 19 deletion; icotinib; non-small-cell lung cancer