title: Further proof to the utility of polysaccharide-based chiral selectors in combination with superficially porous silica particles as effective chiral stationary phases for separation of enantiomers in high-performance liquid chromatography.
abstract: The first ever report on the preparation of chiral stationary phases (CSP) based on superficially porous silica (SPS) particles for the separation of enantiomers in HPLC demonstrated clear advantages of such materials. Higher enantioselectivity at the comparable content of a chiral selector, limited dependence of plate height on the mobile phase flow rate and higher plate numbers and resolution calculated per unit time (i.e. higher speed of separation) were observed with columns made with superficially porous CSP in comparison to columns made with fully-porous silica-based CSP. However, later studies reported diverging conclusions. In this report further evidences are described supporting the findings of our first study about the superior performance of polysaccharide-based chiral selectors in combination with SPS when compared to traditional CSPs based on fully porous silica (FPS) particles.
authors: Institute of Physical and Analytical Chemistry, School of Exact and Natural Sciences, Tbilisi State University, Chavchavadze Ave 3, 0179 Tbilisi, Georgia.
authors: Qetevan
authors: Q
authors: Kharaishvili
authors: Institute of Physical and Analytical Chemistry, School of Exact and Natural Sciences, Tbilisi State University, Chavchavadze Ave 3, 0179 Tbilisi, Georgia.
authors: George
authors: G
authors: Jibuti
authors: Phenomenex Inc., 411 Madrid Ave., Torrance, 90501 CA, USA.
authors: Tivadar
authors: T
authors: Farkas
authors: Institute of Physical and Analytical Chemistry, School of Exact and Natural Sciences, Tbilisi State University, Chavchavadze Ave 3, 0179 Tbilisi, Georgia. Electronic address: jpba_bezhan@yahoo.com.
authors: Bezhan
authors: B
authors: Chankvetadze
mesh_terms: D002851:Chromatography, High Pressure Liquid / Q000379:methods* / Q000592:standards; D011134:Polysaccharides / Q000737:chemistry*; D016062:Porosity; D012822:Silicon Dioxide / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D011134:Polysaccharides; D012822:Silicon Dioxide
keywords: Chiral HPLC; Chiral stationary phases based on superficially porous silica; Enantioseparations; Polysaccharide-based chiral stationary phases