title: Association of inflammation with specific symptoms of depression in a general population of older people: The English Longitudinal Study of Ageing.
abstract: Elevated levels of inflammatory markers, such as C-reactive protein, are well documented in people with depression. Few studies have examined whether the association between inflammation and depression is symptom specific, and differs according to antidepressant treatment. Using data from the English Longitudinal Study of Ageing (N=5909), cross-sectional analyses revealed a significant dose-response association between C-reactive protein and the symptoms of fatigue (P<0.001), restless sleep (P=0.03), low energy (P=0.02) and feeling depressed (P=0.04), but not other symptoms. These associations were absent in users of anti-depressant medication. Our findings suggest the C-reactive protein-depression association is symptom-specific and modified by antidepressant treatment.
authors: Centre for Trials Research, Cardiff University, Cardiff CF14 4YS, UK; Centre for the Development and Evaluation of Complex Interventions for Public Health Improvement (DECIPHer), Cardiff University, Cardiff CF14 4YS, UK. Electronic address: whitej11@cf.ac.uk.
authors: James
authors: J
authors: White
authors: Department of Epidemiology and Public Health, University College London, London, WC1E 7HB, UK; Clinicum, Faculty of Medicine, University of Helsinki, Helsinki, Finland. Electronic address: m.kivimaki@ucl.ac.uk.
authors: Mika
authors: M
authors: Kivimäki
authors: Institute of Behavioural Sciences, University of Helsinki, Helsinki, Finland. Electronic address: markus.jokela@helsinki.fi.
authors: Markus
authors: M
authors: Jokela
authors: Department of Epidemiology and Public Health, University College London, London, WC1E 7HB, UK. Electronic address: david.batty@ucl.ac.uk.
authors: G David
authors: GD
authors: Batty
mesh_terms: D000368:Aged; D000375:Aging / Q000097:blood / Q000523:psychology*; D000928:Antidepressive Agents / Q000627:therapeutic use; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000032:analysis; D003863:Depression / Q000097:blood / Q000188:drug therapy / Q000523:psychology*; D004739:England; D005260:Female; D006801:Humans; D007249:Inflammation / Q000097:blood / Q000523:psychology*; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged
chemical_list: D000928:Antidepressive Agents; D015415:Biomarkers; D002097:C-Reactive Protein
keywords: Antidepressants; C-reactive protein; Depression