title: The relationship of the oleic acid level and ECHDC3 mRNA expression with the extent of coronary lesion.
abstract: BACKGROUND
  The fatty acid profile is associated with the risk and progression of several diseases, probably via mechanisms including its influence on gene expression. We previously reported a correlation between ECHDC3 upregulation and the severity of acute coronary syndrome. Here, we assessed the relationship of serum fatty acid profile and ECHDC3 expression with the extent of coronary lesion.
  
  
  METHODS
  Fifty-nine individuals aged 30 to 74 years and undergoing elective cinecoronariography for the first time were enrolled in the present study. The extent of coronary lesion was assessed by the Friesinger index and patients were classified as without lesion (n = 18), low lesion (n = 17), intermediate lesion (n = 17) and major lesion (n = 7). Serum biochemistry, fatty acid concentration, and ECHDC3 mRNA expression in blood were evaluated.
  
  
  RESULTS
  Elevated serum levels of oleic acid and total monounsaturated fatty acids were observed in patients with low and intermediate lesion, when compared to patients without lesion (p < 0.05). ECHDC3 mRNA expression was 1.2 fold higher in patients with low lesion than in patients without lesion (p = 0.020), and 1.8 fold lower in patients with major lesion patients than in patients with low lesion (p = 0.023).
  
  
  CONCLUSIONS
  Increased levels of monounsaturated fatty acids, especially oleic acid, and ECHDC3 upregulation in patients with coronary artery lesion suggests that these are independent factors associated with the initial progression of cardiovascular disease.
authors: Postgraduate Program of Nutrition, Federal University of Rio Grande do Norte, Natal, Brazil.
authors: Mychelle Kytchia Rodrigues Nunes
authors: MK
authors: Duarte
authors: Department of Clinical and Toxicological Analysis, Federal Universty of Rio Grande do Norte, Natal, Brazil. Avenue General Gustavo Cordeiro de Farias, S/N, Natal, Rio Grande do Norte, CEP: 59014-520, Brazil.
authors: Jéssica Nayara Góes
authors: JN
authors: de Araújo
authors: Department of Clinical and Toxicological Analysis, Federal Universty of Rio Grande do Norte, Natal, Brazil. Avenue General Gustavo Cordeiro de Farias, S/N, Natal, Rio Grande do Norte, CEP: 59014-520, Brazil.
authors: Victor Hugo Rezende
authors: VH
authors: Duarte
authors: Department of Clinical and Toxicological Analysis, Federal Universty of Rio Grande do Norte, Natal, Brazil. Avenue General Gustavo Cordeiro de Farias, S/N, Natal, Rio Grande do Norte, CEP: 59014-520, Brazil.
authors: Katiene Macêdo
authors: KM
authors: de Oliveira
authors: Hospital Universitário Onofre Lopes, Federal University of Rio Grande do Norte, Natal, Brazil.
authors: Juliana Marinho
authors: JM
authors: de Oliveira
authors: Nutrition Department, School of Public Health, University of São Paulo, São Paulo, Brazil.
authors: Antonio Augusto Ferreira
authors: AA
authors: Carioca
authors: Department of Clinical and Toxicological Analysis, Federal Universty of Rio Grande do Norte, Natal, Brazil. Avenue General Gustavo Cordeiro de Farias, S/N, Natal, Rio Grande do Norte, CEP: 59014-520, Brazil.
authors: Raul Hernandes
authors: RH
authors: Bortolin
authors: Department of Clinical and Toxicological Analysis, Federal Universty of Rio Grande do Norte, Natal, Brazil. Avenue General Gustavo Cordeiro de Farias, S/N, Natal, Rio Grande do Norte, CEP: 59014-520, Brazil.
authors: Adriana Augusto
authors: AA
authors: Rezende
authors: Faculty of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil.
authors: Mario Hiroyuki
authors: MH
authors: Hirata
authors: Faculty of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil.
authors: Rosário Domingues
authors: RD
authors: Hirata
authors: Faculty of Medicine (LIM-35), University of São Paulo, São Paulo, Brazil.
authors: Dan Linetzky
authors: DL
authors: Waitzberg
authors: Department of Nutrition, Federal University of Rio Grande do Norte, Natal, Brazil.
authors: Severina Carla Vieira Cunha
authors: SC
authors: Lima
authors: Department of Clinical and Toxicological Analysis, Federal Universty of Rio Grande do Norte, Natal, Brazil. Avenue General Gustavo Cordeiro de Farias, S/N, Natal, Rio Grande do Norte, CEP: 59014-520, Brazil.
authors: André Ducati
authors: AD
authors: Luchessi
authors: Department of Clinical and Toxicological Analysis, Federal Universty of Rio Grande do Norte, Natal, Brazil. Avenue General Gustavo Cordeiro de Farias, S/N, Natal, Rio Grande do Norte, CEP: 59014-520, Brazil. viviansilbiger@hotmail.com.
authors: Vivian Nogueira
authors: VN
authors: Silbiger
mesh_terms: D000328:Adult; D000368:Aged; D002318:Cardiovascular Diseases / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D005229:Fatty Acids, Monounsaturated / Q000378:metabolism*; D005260:Female; D015971:Gene Expression Regulation, Enzymologic; D006801:Humans; D008297:Male; D008875:Middle Aged; D009206:Myocardium / Q000378:metabolism; D019301:Oleic Acid / Q000235:genetics / Q000378:metabolism*; D063994:Peroxisomal Bifunctional Enzyme / Q000096:biosynthesis* / Q000235:genetics; D012333:RNA, Messenger / Q000235:genetics
chemical_list: D005229:Fatty Acids, Monounsaturated; D012333:RNA, Messenger; D019301:Oleic Acid; D063994:Peroxisomal Bifunctional Enzyme
keywords: Cardiovascular diseases; ECHDC3; Friesinger index; Monounsaturated fatty acids; Oleic acid