title: Three-dimensional Segmentation of Retinal Cysts from Spectral-domain Optical Coherence Tomography Images by the Use of Three-dimensional Curvelet Based K-SVD.
abstract: This paper presents a new three-dimensional curvelet transform based dictionary learning for automatic segmentation of intraretinal cysts, most relevant prognostic biomarker in neovascular age-related macular degeneration, from 3D spectral-domain optical coherence tomography (SD-OCT) images. In particular, we focus on the Spectralis SD-OCT (Heidelberg Engineering, Heidelberg, Germany) system, and show the applicability of our algorithm in the segmentation of these features. For this purpose, we use recursive Gaussian filter and approximate the corrupted pixels from its surrounding, then in order to enhance the cystoid dark space regions and future noise suppression we introduce a new scheme in dictionary learning and take curvelet transform of filtered image then denoise and modify each noisy coefficients matrix in each scale with predefined initial 3D sparse dictionary. Dark pixels between retinal pigment epithelium and nerve fiber layer that were extracted with graph theory are considered as cystoid spaces. The average dice coefficient for the segmentation of cystoid regions in whole 3D volume and with-in central 3 mm diameter on the MICCAI 2015 OPTIMA Cyst Segmentation Challenge dataset were found to be 0.65 and 0.77, respectively.
authors: Department of Advanced Medical Technology, Isfahan University of Medical Sciences, Isfahan, Iran; Medical Image and Signal Processing Research Center, Isfahan University of Medical Science, Isfahan, Iran.
authors: Mahdad
authors: M
authors: Esmaeili
authors: Medical Image and Signal Processing Research Center, Isfahan University of Medical Science, Isfahan, Iran.
authors: Alireza Mehri
authors: AM
authors: Dehnavi
authors: Medical Image and Signal Processing Research Center, Isfahan University of Medical Science, Isfahan, Iran.
authors: Hossein
authors: H
authors: Rabbani
authors: Noor Ophthalmology Research Center, Noor Eye Hospital, Tehran, Iran.
authors: Fedra
authors: F
authors: Hajizadeh
keywords: Biomarkers; Cysts; Dictionary learning; Digital curvelet transform; Nerve fibers; Noise; Optical coherence tomography; Retinal pigment epithelium; Wet macular degeneration