title: Point of care with micro fluidic paper based device integrated with nano zeolite-graphene oxide nanoflakes for electrochemical sensing of ketamine.
abstract: The present study was aimed to develop an ultrasensitive technique for electroanalysis of ketamine; a date rape drug. It involved the fabrication of nano-hybrid based electrochemical micro fluidic paper-based analytical device (EμPADs) for electrochemical sensing of ketamine. A paper chip was developed using zeolites nanoflakes and graphene-oxide nanocrystals (Zeo-GO). EμPAD offers many advantages such as facile approach, economical and potential for commercialization. Nanocrystal modified EμPAD showed wide linear range 0.001-5nM/mL and a very low detection limit of 0.001nM/mL. The developed sensor was tested in real time samples like alcoholic and non-alcoholic drinks and found good correlation (99%). The hyphenation of EμPAD integrated with nanocrystalline Zeo-GO for detection of ketamine has immense prospective for field-testing platforms. An extensive development could be made for industrial translation of this fabricated device.
authors: Amity Institute of Nanotechnology, Amity University, Noida, UP, India. Electronic address: jags_biotech@yahoo.co.in.
authors: Jagriti
authors: J
authors: Narang
authors: Amity Institute of Physiotherapy, Amity University, Noida, UP, India. Electronic address: malhotra.nitesh@gmail.com.
authors: Nitesh
authors: N
authors: Malhotra
authors: Amity Institute of Nanotechnology, Amity University, Noida, UP, India.
authors: Chaitali
authors: C
authors: Singhal
authors: Amity Institute of Nanotechnology, Amity University, Noida, UP, India.
authors: Ashish
authors: A
authors: Mathur
authors: Amity Institute of Nanotechnology, Amity University, Noida, UP, India.
authors: Dhritiman
authors: D
authors: Chakraborty
authors: Amity Institute of Nanotechnology, Amity University, Noida, UP, India.
authors: Anusree
authors: A
authors: Anil
authors: Amity Institute of Nanotechnology, Amity University, Noida, UP, India.
authors: Aviraj
authors: A
authors: Ingle
authors: Department of Biochemistry, MD University, Rohtak, Haryana, India.
authors: Chandra S
authors: CS
authors: Pundir
mesh_terms: D000778:Anesthetics, Dissociative / Q000032:analysis*; D001628:Beverages / Q000032:analysis*; D055664:Electrochemical Techniques / Q000295:instrumentation*; D004566:Electrodes; D004867:Equipment Design; D006108:Graphite / Q000737:chemistry*; D007649:Ketamine / Q000032:analysis*; D057230:Limit of Detection; D046210:Microfluidic Analytical Techniques / Q000295:instrumentation; D053758:Nanoparticles / Q000737:chemistry / Q000648:ultrastructure; D010087:Oxides / Q000737:chemistry; D010209:Paper; D019095:Point-of-Care Systems; D017641:Zeolites / Q000737:chemistry*
chemical_list: D000778:Anesthetics, Dissociative; D010087:Oxides; D017641:Zeolites; D007649:Ketamine; D006108:Graphite
keywords: Date-rape drug; Electro-oxidation; Ketamine; Nanocrystal GO–Zeo; Paper based sensor