title: Preparation of Orally Disintegrating Tablets Containing Powdered Tea Leaves with Enriched Levels of Bioactive Compounds by Means of Microwave Irradiation Technique.
abstract: In the present study, a microwave treatment process has been applied to prepare orally disintegrating tablets (ODTs) containing powdered tea leaves with enriched levels of the anti-inflammatory compounds such as chafuroside A (CFA) and chafuroside B (CFB). The use of distilled water as the adsorbed and granulation solvents in this preparation process afforded tablets with a long disintegration time (more than 120 s). The CFA and CFB contents of these tablets did not also change after 4 min of microwave irradiation due to the tablet temperature, which only increased to 100°C. In contrast, the tablet temperature increased up to 140°C after 3 min of microwave irradiation when a 1.68 M Na2HPO4 solution instead of distilled water. Notably, the disintegration time of these tablets was considerably improved (less than 20 s) compared with the microwave-untreated tablets, and there were 7- and 11-fold increases in their CFA and CFB contents. In addition, the operational conditions for the preparation of the tablets were optimized by face-centered composite design based on the following criteria: tablet hardness greater than 13 N, disintegration time less than 30 s and friability less than 0.5%. The requirements translated into X1 (the amount of granulation solvent), X2 (tableting pressure) and X3 (content of the powdered tea leaves) values of 45%, 0.43 kN and 32%, respectively, and the ODTs containing powdered tea leaves prepared under these optimized conditions were found to show excellent tablet properties and contain enriched levels of CFA and CFB.
authors: School of Pharmaceutical Sciences, University of Shizuoka.
authors: Hironori
authors: H
authors: Tanaka
authors: Yasunori
authors: Y
authors: Iwao
authors: Masahiro
authors: M
authors: Izumikawa
authors: Syusuke
authors: S
authors: Sano
authors: Hitoshi
authors: H
authors: Ishida
authors: Shuji
authors: S
authors: Noguchi
authors: Shigeru
authors: S
authors: Itai
mesh_terms: D000284:Administration, Oral; D047309:Flavones / Q000032:analysis; D006576:Heterocyclic Compounds, 4 or More Rings / Q000032:analysis; D008872:Microwaves; D018515:Plant Leaves / Q000737:chemistry*; D011208:Powders; D013607:Tablets / Q000008:administration & dosage / Q000138:chemical synthesis / Q000737:chemistry* / Q000528:radiation effects*; D013662:Tea / Q000737:chemistry*
chemical_list: C510948:3,4,11-trihydroxy-2-(hydroxymethyl)-8-(4-hydroxyphenyl)-3,4,4a,11b-tetrahydro-2H,10H-pyrano(2',3'-4,5)furo(3,2-g)chromen-10-one; D047309:Flavones; D006576:Heterocyclic Compounds, 4 or More Rings; D011208:Powders; D013607:Tablets; D013662:Tea