title: Hypertensive disorders of pregnancy and outcomes of preterm infants of 24 to 28 weeks' gestation.
abstract: To examine the relationship between hypertensive disorders of pregnancy (HDPs) and mortality and major morbidities in preterm neonates born at 24 to 28 weeks of gestation.
  
  
  
  Using an international cohort, we retrospectively studied 27 846 preterm neonates born at 240to 286weeks of gestation during 2007 to 2010 from 6 national neonatal databases. The incidence of HDP was compared across countries, and multivariable logistic regression analyses were conducted to examine the association of HDP and neonatal outcomes including mortality to discharge, bronchopulmonary dysplasia, severe brain injury, necrotizing enterocolitis and treated retinopathy of prematurity.
  
  
  
  The incidence of HDP in the entire cohort was 13% (range 11 to 16% across countries). HDP was associated with reduced odds of mortality (adjusted odds ratio (aOR) 0.77; 95% confidence interval (CI) 0.67 to 0.88), severe brain injury (aOR 0.74; 95% CI 0.62 to 0.89) and treated retinopathy (aOR 0.82; 95% CI 0.70 to 0.96), but increased odds of bronchopulmonary dysplasia (aOR 1.16; 95% CI 1.05 to 1.27).
  
  
  
  In comparison with neonates born to mothers without HDP, neonates of HDP mothers had lower odds of mortality, severe brain injury and treated retinopathy, but higher odds of bronchopulmonary dysplasia. The impact of maternal HDP on newborn outcomes was inconsistent across outcomes and among countries; therefore, further international collaboration to standardize terminology, case definition and data capture is warranted.
authors: Canadian Neonatal Network, Maternal-Infant Care Research Centre, Department of Pediatrics, Mount Sinai Hospital, Toronto, Ontario, Canada.
authors: L
authors: L
authors: Gemmell
authors: Canadian Neonatal Network, Maternal-Infant Care Research Centre, Department of Pediatrics, Mount Sinai Hospital, Toronto, Ontario, Canada.
authors: L
authors: L
authors: Martin
authors: Department of Obstetrics and Gynecology, Mount Sinai Hospital and University of Toronto, Toronto, Ontario, Canada.
authors: K E
authors: KE
authors: Murphy
authors: UK Neonatal Collaborative, Neonatal Data Analysis Unit, Section of Neonatal Medicine, Department of Medicine, Imperial College London, Chelsea and Westminster Hospital Campus, London, UK.
authors: N
authors: N
authors: Modi
authors: Swedish Neonatal Quality Register, Department of Pediatrics/Neonatal Services, Umeå University Hospital, Umeå, Sweden.
authors: S
authors: S
authors: Håkansson
authors: Israel Neonatal Network, Gertner Institute for Epidemiology and Health Policy Research, Sheba Medical Centre, Tel Hashomer, Israel.
authors: B
authors: B
authors: Reichman
authors: Australian and New Zealand Neonatal Network, Royal Hospital for Women, National Perinatal Epidemiology and Statistic Unit, University of New South Wales, Randwick, New South Wales, Australia.
authors: K
authors: K
authors: Lui
authors: Neonatal Research Network Japan, Maternal and Perinatal Center, Tokyo Women's Medical University, Tokyo, Japan.
authors: S
authors: S
authors: Kusuda
authors: Swedish Neonatal Quality Register, Uppsala University, Department of Women's and Children's Health, Uppsala, Sweden.
authors: G
authors: G
authors: Sjörs
authors: Canadian Neonatal Network, Maternal-Infant Care Research Centre, Department of Pediatrics, Mount Sinai Hospital, Toronto, Ontario, Canada.
authors: L
authors: L
authors: Mirea
authors: Australia and New Zealand Neonatal Network, Department of Paediatrics, University of Otago, Christchurch, New Zealand.
authors: B A
authors: BA
authors: Darlow
authors: Neonatal Research Network Japan, Department of Health Policy, National Center for Child Health and Development, Tokyo, Japan.
authors: R
authors: R
authors: Mori
authors: Canadian Neonatal Network, Maternal-Infant Care Research Centre, Department of Pediatrics, Mount Sinai Hospital, Toronto, Ontario, Canada.|Department of Pediatrics, Mount Sinai Hospital and University of Toronto, Toronto, Ontario, Canada.
authors: S K
authors: SK
authors: Lee
authors: Canadian Neonatal Network, Maternal-Infant Care Research Centre, Department of Pediatrics, Mount Sinai Hospital, Toronto, Ontario, Canada.|Department of Pediatrics, Mount Sinai Hospital and University of Toronto, Toronto, Ontario, Canada.
authors: P S
authors: PS
authors: Shah
mesh_terms: D001720:Birth Injuries / Q000453:epidemiology; D001997:Bronchopulmonary Dysplasia / Q000453:epidemiology; D016022:Case-Control Studies; D016208:Databases, Factual; D020345:Enterocolitis, Necrotizing / Q000453:epidemiology; D005260:Female; D005865:Gestational Age; D006801:Humans; D046110:Hypertension, Pregnancy-Induced / Q000453:epidemiology*; D015994:Incidence; D007223:Infant; D007226:Infant Mortality; D062071:Infant, Extremely Premature; D007231:Infant, Newborn; D016015:Logistic Models; D016017:Odds Ratio; D011247:Pregnancy; D011256:Pregnancy Outcome / Q000453:epidemiology*; D012178:Retinopathy of Prematurity / Q000453:epidemiology; D012189:Retrospective Studies