title: Poly(styrenesulfonate)-Modified Ni-Ti Layered Double Hydroxide Film: A Smart Drug-Eluting Platform.
abstract: Drug-eluting stents (DESs) are widely used in the palliative treatment of many kinds of cancers. However, the covered polymers used in DESs are usually associated with stent migration and acute cholecystitis. Therefore, developing noncovered drug-loading layers on metal stents is of great importance. In this work, Ni-Ti layered double hydroxide (Ni-Ti LDH) films were prepared on the surface of nitinol via hydrothermal treatment, and the LDH films were further modified by poly(styrenesulfonate) (PSS). The anticancer drug doxorubicin could be effectively loaded onto the modified films, and drug release could be smartly controlled by the pH. Besides, the drug absorption amounts of cancer cells cultured on the films could be effectively improved. These results indicate that the PSS-modified LDH film may become a promising drug-loading platform that can be used in the design of DESs.
authors: Intervention Center, Eastern Hepatobilialy Surgery Hospital, The Second Military Medical University , Shanghai 200438, China.
authors: Naijian
authors: N
authors: Ge
authors: State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences , Shanghai 200050, China.
authors: Donghui
authors: D
authors: Wang
authors: State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences , Shanghai 200050, China.
authors: Feng
authors: F
authors: Peng
authors: State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences , Shanghai 200050, China.
authors: Jinhua
authors: J
authors: Li
authors: State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences , Shanghai 200050, China.
authors: Yuqin
authors: Y
authors: Qiao
authors: State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences , Shanghai 200050, China.
authors: Xuanyong
authors: X
authors: Liu
mesh_terms: D065546:Drug Liberation; D054855:Drug-Eluting Stents; D006878:Hydroxides; D009532:Nickel; D011137:Polystyrenes / Q000737:chemistry*; D014025:Titanium
chemical_list: D006878:Hydroxides; D011137:Polystyrenes; C040654:titanium nickelide; C003321:polystyrene sulfonic acid; D009532:Nickel; D014025:Titanium
keywords: Ni−Ti LDH; PSS; cancer; drug internalization; drug-eluting stents; pH-responsive