title: Involvement of Non-coding RNAs in the Signaling Pathways of Colorectal Cancer.
abstract: Colorectal cancer (CRC) is one of the most common diagnosed cancers worldwide. The metastasis and development of resistance to anti-cancer treatment are major challenges in the treatment of CRC. Understanding mechanisms underpinning the pathogenesis is therefore critical in developing novel agents for CRC treatments. A large number of evidence has demonstrated that non-coding RNAs (ncRNAs), including microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and circular RNAs have functional roles in both the physiological and pathological processes by regulating the expression of their target genes. These molecules are engaged in the pathobiology of neoplastic diseases and are targets for the diagnosis, prognosis and therapy of a variety of cancers, including CRC. In this regard, ncRNAs have emerged as one of the hallmarks of CRC pathogenesis and they also play key roles in metastasis, drug resistance and the stemness of CRC stem cell by regulating various signaling networks. Therefore, a better understanding the ncRNAs involved in the signaling pathways of CRC may lead to the development of novel strategy for diagnosis, prognosis and treatment of CRC. In this chapter, we summarize the latest findings on ncRNAs, with a focus on miRNAs and lncRNAs involving in signaling networks and in the regulation of pathogenic signaling pathways in CRC.
authors: The General Hospital, Ningxia Medical University, Yinchuan, 750004, Ningxia, China.
authors: Yinxue
authors: Y
authors: Yang
authors: The General Hospital, Ningxia Medical University, Yinchuan, 750004, Ningxia, China.
authors: Yong
authors: Y
authors: Du
authors: The General Hospital, Ningxia Medical University, Yinchuan, 750004, Ningxia, China.
authors: Xiaoming
authors: X
authors: Liu
authors: Department of Clinical Oncology, Queen Elizabeth Hospital, Hong Kong, China. chocs@ha.org.hk.
authors: William C
authors: WC
authors: Cho
mesh_terms: D002471:Cell Transformation, Neoplastic / Q000235:genetics; D015179:Colorectal Neoplasms / Q000209:etiology / Q000235:genetics* / Q000473:pathology; D018450:Disease Progression; D015972:Gene Expression Regulation, Neoplastic / Q000235:genetics*; D006801:Humans; D035683:MicroRNAs / Q000235:genetics; D009362:Neoplasm Metastasis; D009363:Neoplasm Proteins / Q000502:physiology; D012313:RNA / Q000235:genetics; D000079962:RNA, Circular; D062085:RNA, Long Noncoding / Q000235:genetics; D012334:RNA, Neoplasm / Q000235:genetics*; D022661:RNA, Untranslated / Q000235:genetics*; D015398:Signal Transduction / Q000235:genetics
chemical_list: D035683:MicroRNAs; D009363:Neoplasm Proteins; D000079962:RNA, Circular; D062085:RNA, Long Noncoding; D012334:RNA, Neoplasm; D022661:RNA, Untranslated; D012313:RNA
keywords: Colorectal cancer (CRC); Long non-coding RNA (lncRNA); MicroRNA (miRNA); Non-coding RNAs (ncRNAs); Signaling pathway