title: An Unusual Tetrahydrofuran Lignan from the Roots of Zanthoxylum planispinum and the Potential Anti-inflammatory Effects.
abstract: An unusual tetrahydrofuran lignin, zanthplanispine (1), together with 14 known lignans (2 - 15) were isolated from the AcOEt-soluble fraction from the MeOH extract of Z. planispinum roots. The structures of 1 was elucidated on the basis of 1D- and 2D-NMR experiments as well as HR-ESI-MS analysis. The known compounds were identified by the comparison of their NMR data with previously reported in the literatures. Bioassay showed that compounds 1 - 4 could inhibit nitric oxide (NO) production in lipopolysaccharide (LPS) stimulated RAW 264.7 cells. In particular, compound 1 showed significant inhibitory activity with an IC50value of 36.8 μm.
authors: School of Food Science and Biotechnology, Zhejiang Gongshang University, Hangzhou, 310018, P. R. China.
authors: Guang-Yao
authors: GY
authors: Su
authors: Library, Zhejiang University of Finance & Economics, Hangzhou, 310018, P. R. China.
authors: Yu-Chun
authors: YC
authors: Cheng
authors: School of Food Science and Biotechnology, Zhejiang Gongshang University, Hangzhou, 310018, P. R. China.
authors: Kui-Wu
authors: KW
authors: Wang
authors: School of Food Science and Biotechnology, Zhejiang Gongshang University, Hangzhou, 310018, P. R. China.|Key Laboratory of Fruits and Vegetables Postharvest and Processing Technology Research of Zhejiang Province, Hangzhou, 310018, P. R. China.
authors: Xiang-Yang
authors: XY
authors: Wang
authors: Ocean College, Zhejiang University, Hangzhou, 310058, P. R. China.
authors: Bin
authors: B
authors: Wu
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D005663:Furans; D020128:Inhibitory Concentration 50; D017705:Lignans / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D051379:Mice; D009569:Nitric Oxide / Q000037:antagonists & inhibitors; D010936:Plant Extracts / Q000737:chemistry; D018517:Plant Roots / Q000737:chemistry; D000067996:RAW 264.7 Cells; D032106:Zanthoxylum / Q000737:chemistry*
chemical_list: D000893:Anti-Inflammatory Agents; D005663:Furans; D017705:Lignans; D010936:Plant Extracts; D009569:Nitric Oxide; C018674:tetrahydrofuran
keywords: 
  Zanthoxylum planispinum
  ; Anti-inflammatory activity; Tetrahydrofuran lignan; Zanthplanispine