title: Mass drug administration and the global control of schistosomiasis: successes, limitations and clinical outcomes.
abstract: Preventive chemotherapy is advocated for the global control and elimination of schistosomiasis. Despite the well known short-term benefits of treating patients for schistosomiasis, the impact of mass drug administration (MDA) campaigns to control the disease in the long term remains unresolved.
  
  
  
  Many studies have advocated the success of MDA programs in order to attract donor funds for elimination efforts but such successes are often short-lived given the drug does not alter the life cycle of the organism or prevent reinfection. Within a matter of months to years after halting treatment, the prevalence, intensity of infection and morbidity of disease return to baseline levels. Other mitigating factors contribute to the failings of MDA campaigns namely: poverty, poor drug coverage, poor drug compliance, and, in the case of Asiatic schistosomiasis, zoonotic transmission. Genetic and innate and acquired immunologic mechanisms complicate the epidemiologic picture of schistosomiasis globally, and may contribute indirectly to MDA shortcomings. The possibility of drug resistance is an ever present concern because of the sole reliance on one drug, praziquantel.
  
  
  
  Preventive chemotherapy is advocated for the global control and elimination of schistosomiasis. The short-term benefits of MDA campaigns are well documented but the long-term benefits are questionable.
authors: aMenzies Health Institute Queensland, Griffith University, Gold Coast bQIMR Berghofer Medical Research Institute, Brisbane City, Queensland, Australia.
authors: David U
authors: DU
authors: Olveda
authors: Donald P
authors: DP
authors: McManus
authors: Allen G P
authors: AG
authors: Ross
mesh_terms: D000871:Anthelmintics / Q000008:administration & dosage*; D060740:Disease Eradication / Q000379:methods; D014943:Global Health; D006293:Health Promotion; D006801:Humans; D011223:Praziquantel / Q000008:administration & dosage; D015995:Prevalence; D012008:Recurrence; D012552:Schistosomiasis / Q000188:drug therapy* / Q000453:epidemiology / Q000517:prevention & control; D012959:Socioeconomic Factors
chemical_list: D000871:Anthelmintics; D011223:Praziquantel