title: [Treatment of bilateral spontaneous pneumothorax during pazopanib therapy for pulmonary soft tissue sarcoma metastases. What to do when there is so few evidence?]
abstract: Soft tissue sarcomas are rare malignant tumors with a great variety of histological types and different response to multimodality treatment. Pazopanib has been recently introduced for the treatment of non-adipocytic metastatic soft tissue sarcomas which are resistant to conventional chemotherapy. Spontaneous pneumothorax is a rare but well recognized complication of this molecule and its treatment is quite challenging. The case reported herein describes the surgical management of a simultaneous bilateral spontaneous pneumothorax in a patient with pulmonary metastases treated with pazopanib. It underlines the fact that the main objective should be the maintenance of the treatment in patients who benefit from it. Close oncologic and surgical collaboration is crucial in order to deal with adverse effects due to the anti-angiogenic action of pazopanib.
authors: Service de chirurgie générale, urgences et chirurgie thoracique, centre hospitalo-universitaire de Nancy, 29, avenue du Maréchal-de-Lattre-de-Tassigny, 54035 Nancy, France. Electronic address: a.agrafiotis@chu-nancy.fr.
authors: A C
authors: AC
authors: Agrafiotis
authors: Service de chirurgie générale, urgences et chirurgie thoracique, centre hospitalo-universitaire de Nancy, 29, avenue du Maréchal-de-Lattre-de-Tassigny, 54035 Nancy, France.
authors: M
authors: M
authors: Prieto
authors: Institut de cancérologie de Lorraine, Alexis Vautrin, 6, avenue de Bourgogne, 54500 Vandoeuvre-lès-Nancy, France.
authors: J-L
authors: JL
authors: Verhaeghe
authors: Service de chirurgie générale, urgences et chirurgie thoracique, centre hospitalo-universitaire de Nancy, 29, avenue du Maréchal-de-Lattre-de-Tassigny, 54035 Nancy, France.
authors: J
authors: J
authors: Siat
authors: Service de chirurgie générale, urgences et chirurgie thoracique, centre hospitalo-universitaire de Nancy, 29, avenue du Maréchal-de-Lattre-de-Tassigny, 54035 Nancy, France.
authors: G
authors: G
authors: Grosdidier
authors: Institut de cancérologie de Lorraine, Alexis Vautrin, 6, avenue de Bourgogne, 54500 Vandoeuvre-lès-Nancy, France.
authors: M
authors: M
authors: Rios
mesh_terms: D006801:Humans; D007191:Indazoles; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000556:secondary; D008297:Male; D008875:Middle Aged; D019042:Muscle Neoplasms / Q000188:drug therapy / Q000473:pathology; D011013:Pneumonectomy; D011030:Pneumothorax / Q000139:chemically induced* / Q000628:therapy*; D011743:Pyrimidines / Q000009:adverse effects / Q000627:therapeutic use*; D012509:Sarcoma / Q000188:drug therapy* / Q000556:secondary; D013449:Sulfonamides / Q000009:adverse effects / Q000627:therapeutic use*
chemical_list: D007191:Indazoles; D011743:Pyrimidines; D013449:Sulfonamides; C516667:pazopanib
keywords: Pazopanib; Pneumothorax spontané; Sarcome; Soft tissue sarcoma; Spontaneous pneumothorax