title: Effect of aqueous extract of the Vigna angularis in rats subjected to an experimental model of moderate chronic kidney disease.
abstract: OBJECTIVE
  To evaluate the effect of the aqueous extract of the Vigna angularis, popularly known as "Azuki beans", in rats subjected to an experimental model of moderate chronic kidney disease.
  
  
  METHODS
  Thirty rats underwent two surgeries - Ormrod and Miller (1980) - to obtain Moderate Chronic Kidney Disease (CKD-M). The animals were randomized into 3 groups. Group 1 (Control): distilled water. Group 2 (Azuki): Vigna angularis 5% aqueous extract. Group 3 (Treatment): 10mg/kg of enalapril maleate. The rats received their respective treatments for 14 days.
  
  
  RESULTS
  The treatment with azuki beans produced an increase in urine output from the second day until the end of the experiment compared to the Control groups (p<0.01) and Treatment (p<0.05). The treatment with azuki also produced significant reductions in the levels of glucose, triglycerides, VLDL, uric acid, Alanine aminotransferase (p<0.05), urea and serum creatinine (p<0.01), besides having produced a significant increase in the levels of HDL when compared to the Control group.
  
  
  CONCLUSIONS
  Treatment with Azuki beans produced improvements in the parameters of renal function and significantly reduced glucose levels, triglycerides, VLDL, alanine aminostransferase, uric acid and creatinine, besides having produced a significant increase in the levels of HDL in rats submitted to a model of moderate chronic kidney disease.
authors: PhD, Full Professor, Pharmacology and Biochemistry, Medical School of Itajubá (FMIt), Brazil. Conception and design of the study, critical revision, final approval.
authors: Nilo César do Vale
authors: NC
authors: Baracho
authors: Graduate student, FMIt, Itajuba-MG, Brazil. Acquisition, analysis and interpretation of data; technical procedures; statitics analysis; manuscript preparation.
authors: Natália Fechus
authors: NF
authors: Monteiro
authors: Graduate student, FMIt, Itajuba-MG, Brazil. Technical procedures.
authors: Manuela Guedes
authors: MG
authors: Borges
authors: Graduate student, FMIt, Itajuba-MG, Brazil. Technical procedures.
authors: Raíssa Robles de Moura
authors: RR
authors: Arguelho
mesh_terms: D000818:Animals; D003404:Creatinine / Q000097:blood; D004353:Drug Evaluation, Preclinical; D008297:Male; D008517:Phytotherapy; D010936:Plant Extracts / Q000627:therapeutic use*; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D051436:Renal Insufficiency, Chronic / Q000188:drug therapy*; D014280:Triglycerides / Q000097:blood; D014508:Urea / Q000097:blood; D000070658:Vigna / Q000737:chemistry*
chemical_list: D010936:Plant Extracts; D014280:Triglycerides; D014508:Urea; D003404:Creatinine