title: Comparison of the molecular profile of brain metastases from colorectal cancer and corresponding primary tumors.
abstract: OBJECTIVE
  Little is known about molecular biology of brain metastasis (BM) from colorectal cancer and its concordance with matched primary tumors.
  
  
  METHODS
  We identified 56 consecutive colorectal cancer patients who underwent neurosurgical resection of BM. Tumor samples were tested for KRAS, NRAS, BRAF and PIK3CA. The molecular profile of the brain lesion was compared with the corresponding primary tumor.
  
  
  RESULTS
  The molecular profile concordance rate was 95.1%. Median survival after neurosurgery was 5.5 months (95% CI: 4.7-6.3); median overall survival was 24.0 months (95% CI: 15.6-32.4).
  
  
  CONCLUSIONS
  In this cohort, we report a high frequency of KRAS mutations and a very high concordance rate between the molecular status of BM and that of matched primary tumors.
authors: Department of Oncology, University & General Hospital, Piazzale S Maria della Misericordia 15, 33100, Udine, Italy.
authors: Giuseppe
authors: G
authors: Aprile
authors: Department of Oncology, University & General Hospital, Piazzale S Maria della Misericordia 15, 33100, Udine, Italy.
authors: Mariaelena
authors: M
authors: Casagrande
authors: Department of Pathology, University & General Hospital, Piazzale S Maria della Misericordia 15, 33100, Udine, Italy.
authors: Giovanna
authors: G
authors: De Maglio
authors: Department of Oncology, University & General Hospital, Piazzale S Maria della Misericordia 15, 33100, Udine, Italy.
authors: Caterina
authors: C
authors: Fontanella
authors: Department of Oncology, University & General Hospital, Piazzale S Maria della Misericordia 15, 33100, Udine, Italy.
authors: Karim
authors: K
authors: Rihawi
authors: Department of Oncology, University & General Hospital, Piazzale S Maria della Misericordia 15, 33100, Udine, Italy.
authors: Marta
authors: M
authors: Bonotto
authors: Institute of Hygiene & Clinical Epidemiology, University & General Hospital, Piazzale S Maria della Misericordia 15, 33100, Udine, Italy.
authors: Federica E
authors: FE
authors: Pisa
authors: Department of Neurosurgery, University & General Hospital, Piazzale S Maria della Misericordia 15, 33100, Udine, Italy.
authors: Francesco
authors: F
authors: Tuniz
authors: Department of Pathology, University & General Hospital, Piazzale S Maria della Misericordia 15, 33100, Udine, Italy.
authors: Stefano
authors: S
authors: Pizzolitto
authors: Department of Oncology, University & General Hospital, Piazzale S Maria della Misericordia 15, 33100, Udine, Italy.
authors: Gianpiero
authors: G
authors: Fasola
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor; D001932:Brain Neoplasms / Q000235:genetics* / Q000401:mortality / Q000556:secondary*; D015179:Colorectal Neoplasms / Q000235:genetics* / Q000401:mortality / Q000473:pathology*; D005260:Female; D020869:Gene Expression Profiling / Q000379:methods; D023281:Genomics / Q000379:methods; D006801:Humans; D008297:Male; D008875:Middle Aged; D009154:Mutation; D011379:Prognosis; D012189:Retrospective Studies
chemical_list: D014408:Biomarkers, Tumor
keywords: BRAF; KRAS; PIK3CA; RAS; brain metastases; colorectal cancer