title: β-Defensin-2 is overexpressed in human vocal cord polyps.
abstract: The objective of the study is to investigate the expression of human β-defensin-1 (hBD-1) and human β-defensin-2 (hBD-2) in vocal cord polyps using tissue microarray. Tissue specimens from vocal cord polyps (N = 51), vocal cord nodules (N = 26), and healthy vocal cords (N = 8) were retrieved from the biobank of the Department of Pathology of Tianjin Tianhe Hospital between 2003 and 2006 and immunostained on tissue microarrays for the quantitative analysis of hBD-1 and hBD-2 expression. hBD-1 expression did not differ significantly between healthy vocal cords, vocal cord nodules, and vocal cord polyps (p = 0.904). In contrast, hBD-2 expression was significantly higher in vocal cord polyps compared to vocal cord nodules and healthy vocal cords (p < 0.001). The expression of hBD-2, but not hBD-1, is elevated in vocal cord polyp epithelium. This suggests that hBD-1 has a more constitutive role in host defense in the vocal cords, whereas hBD-2 expression may be a result of local inflammation or the presence of invading pathogens.
authors: Department of Otorhinolaryngology, Second Hospital, Tianjin Medical University, Tianjin, 300211, People's Republic of China. xixi790515@sina.com.
authors: Jinjin
authors: J
authors: Gu
authors: Department of Otorhinolaryngology, Second Hospital, Tianjin Medical University, Tianjin, 300211, People's Republic of China.
authors: Yongwang
authors: Y
authors: Huang
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D007818:Laryngeal Diseases / Q000378:metabolism* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D011127:Polyps / Q000378:metabolism* / Q000473:pathology; D046888:Tissue Array Analysis; D014827:Vocal Cords / Q000378:metabolism* / Q000473:pathology; D023083:beta-Defensins / Q000378:metabolism*
chemical_list: C406407:DEFB1 protein, human; C106641:DEFB4A protein, human; D023083:beta-Defensins
keywords: Defensins; Immunohistochemistry; Tissue microarray; Vocal cord polyps; hBD-1; hBD-2