title: Nasal Polyp - An Incidental Paraganglioma.
abstract: The nose is an uncommon site for head and neck paraganglioma. The diagnosis is seldom established pre-operatively; its rarity, infrequent functionality and often benign biologic outcome underlie this fact. We present one such case in a 60-year-old man who presented with right nasal obstruction and episodic epistaxis. Rhinoscopy revealed a fleshy polypoid mass arising from the anterior cartilaginous nasal septum. Imaging studies excluded extra-nasal extension. The tumor was highly vascular showing numerous variable sized, mostly thin walled branching blood vessels akin to stag-horn shape simulating a vascular neoplasm. There were large areas of hyalinization. The typical tumor morphology was discernible only in focal areas. Immuno-histochemistry confirmed the diagnosis. The tumor cells expressed neuron specific enolase; S-100 stain demonstrated a vague zell-ballen pattern. Paraganglioma is a rare histologic diagnosis in nasal polypectomy specimen. We discuss the approach to exclude its morphologic mimics including vascular tumors.
authors: Department of Pathology, University College of Medical Sciences, DELHI, INDIA.
authors: Ruchi
authors: R
authors: Srivastava
authors: Neelam
authors: N
authors: Wadhwa
authors: Shikha
authors: S
authors: Gupta
authors: Urvashi
authors: U
authors: Razdan
mesh_terms: D014408:Biomarkers, Tumor; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D009298:Nasal Polyps / Q000473:pathology*; D009669:Nose Neoplasms / Q000473:pathology*; D010236:Paraganglioma, Extra-Adrenal / Q000473:pathology*
chemical_list: D014408:Biomarkers, Tumor