title: Retroperitoneal Sarcoma: Fact, Opinion, and Controversy.
abstract: After diagnosis of retroperitoneal sarcoma (RPS), detailed imaging and multidisciplinary discussion should guide treatment including surgical resection and in select cases, neoadjuvant therapy. Local recurrence is common in RPS and is associated with grade, histologic subtype, completeness of resection, and size. As guidelines to standardize RPS patient management emerge, expert pathologic assessment and management in centers of excellence are benchmarks of quality of care. The efficacy of current chemotherapy is limited and there is a critical need to understand the molecular basis of sarcoma so that new drug therapies are developed. Multicenter clinical trials are needed to limit opinion and controversy in this complex and challenging disease.
authors: Department of Surgery, Mount Sinai Hospital, University of Toronto, 600 University Avenue, Suite 1225, Toronto, Ontario M5G 1X5, Canada; Department of Surgical Oncology, Princess Margaret Cancer Centre, 610 University Avenue, 3rd Floor, Toronto, Ontario M5G 2M9, Canada. Electronic address: rgladdy@mtsinai.on.ca.
authors: Rebecca A
authors: RA
authors: Gladdy
authors: Division of Pediatric Hematology/Oncology, Department of Pediatrics, The Hospital for Sick Children, University of Toronto, Room 9215, Toronto, Ontario M5G 1X8, Canada; Department of Medical Oncology, Princess Margaret Cancer Centre, 610 University Avenue, 5th Floor, Toronto, Ontario M5G 2M9, Canada.
authors: Abha
authors: A
authors: Gupta
authors: Department of Radiation Oncology, University of Toronto, FitzGerald Building, Room 106, 150 College Street, Toronto, Ontario M5S 3E2, Canada; Radiation Medicine Program, Princess Margaret Cancer Centre, 610 University Avenue, 5th Floor, Toronto, Ontario M5G 2M9, Canada.
authors: Charles N
authors: CN
authors: Catton
mesh_terms: D003131:Combined Modality Therapy / Q000379:methods* / Q000639:trends; D006801:Humans; D020360:Neoadjuvant Therapy; D009364:Neoplasm Recurrence, Local; D012186:Retroperitoneal Neoplasms / Q000473:pathology* / Q000601:surgery*; D012509:Sarcoma / Q000473:pathology / Q000601:surgery* / Q000628:therapy; D016896:Treatment Outcome
keywords: Chemotherapy; Local recurrence; Radiation therapy; Retroperitoneal sarcoma; Soft tissue sarcoma; Surgery