title: Analysis of Immune Epitopes of Respiratory Syncytial Virus for Designing of Vectored Vaccines Based on Influenza Virus Platform.
abstract: The immunoepitope database was used for analysis of experimentally detected epitopes of the respiratory syncytial virus (RSV) proteins and for selection of the epitope combinations for subsequent designing of recombinant vectored anti-RSV vaccines based on attenuated influenza viruses. Three cassettes containing the most promising B- and T-cell RSV epitopes were selected: peptide F (243-294) supporting the formation of humoral immunity in animals; fragment M2-1 (70-101+114-146) containing two MHC I epitopes (82-90 and 127-135); and MHC II-epitope (51-66). The selected constructions contained no neoepitopes causing undesirable effects of vaccination, such as immunotolerance or autoimmunity.
authors: A. A. Smorodintsev Department of Virology, Institute of Experimental Medicine, St. Petersburg, Russia. isakova.sivak@gmail.com.
authors: I N
authors: IN
authors: Isakova-Sivak
authors: A. A. Smorodintsev Department of Virology, Institute of Experimental Medicine, St. Petersburg, Russia.
authors: D A
authors: DA
authors: Korenkov
authors: A. A. Smorodintsev Department of Virology, Institute of Experimental Medicine, St. Petersburg, Russia.
authors: E A
authors: EA
authors: Fedorova
authors: A. A. Smorodintsev Department of Virology, Institute of Experimental Medicine, St. Petersburg, Russia.
authors: T S
authors: TS
authors: Tretiak
authors: A. A. Smorodintsev Department of Virology, Institute of Experimental Medicine, St. Petersburg, Russia.
authors: V A
authors: VA
authors: Matyushenko
authors: A. A. Smorodintsev Department of Virology, Institute of Experimental Medicine, St. Petersburg, Russia.
authors: T A
authors: TA
authors: Smolonogina
authors: A. A. Smorodintsev Department of Virology, Institute of Experimental Medicine, St. Petersburg, Russia.
authors: L G
authors: LG
authors: Rudenko
mesh_terms: D000818:Animals; D000939:Epitopes / Q000276:immunology*; D051379:Mice; D009975:Orthomyxoviridae / Q000276:immunology*; D022261:Respiratory Syncytial Virus Vaccines / Q000276:immunology; D012136:Respiratory Syncytial Viruses / Q000276:immunology*
chemical_list: D000939:Epitopes; D022261:Respiratory Syncytial Virus Vaccines
keywords: immunodominant epitope; influenza virus; respiratory syncytial virus; vectored vaccine