title: Vaccine-induced rabies case in a cow (Bos taurus): Molecular characterisation of vaccine strain in brain tissue.
abstract: Rabies is a fatal neuropathogenic zoonosis caused by the rabies virus of the Lyssavirus genus, Rhabdoviridae family. The oral vaccination of foxes - the main reservoir of rabies in Europe - using a live attenuated rabies virus vaccine was successfully conducted in many Western European countries. In July 2015, a rabies vaccine strain was isolated from the brain tissues of a clinically suspect cow (Bos taurus) in Romania. The nucleotide analysis of both N and G gene sequences showed 100% identity between the rabid animal, the GenBank reference SAD B19 strain and five rabies vaccine batches used for the national oral vaccination campaign targeting foxes.
authors: Institute for Diagnosis and Animal Health, Bucharest, Romania; University of Agronomic Study and Veterinary Medicine, Faculty of Veterinary Medicine, Bucharest, Romania.
authors: Vlad
authors: V
authors: Vuta
authors: Nancy OIE/WHO/EU Laboratory for Rabies and Wildlife, French Agency for Food, Environmental and Occupational Health & Safety, Malzéville, France.
authors: Evelyne
authors: E
authors: Picard-Meyer
authors: Nancy OIE/WHO/EU Laboratory for Rabies and Wildlife, French Agency for Food, Environmental and Occupational Health & Safety, Malzéville, France.
authors: Emmanuelle
authors: E
authors: Robardet
authors: Institute for Diagnosis and Animal Health, Bucharest, Romania.
authors: Gheorghe
authors: G
authors: Barboi
authors: Institute for Diagnosis and Animal Health, Bucharest, Romania.
authors: Razvan
authors: R
authors: Motiu
authors: Institute for Diagnosis and Animal Health, Bucharest, Romania; University of Agronomic Study and Veterinary Medicine, Faculty of Veterinary Medicine, Bucharest, Romania.
authors: Florica
authors: F
authors: Barbuceanu
authors: University of Agronomic Study and Veterinary Medicine, Faculty of Veterinary Medicine, Bucharest, Romania.
authors: Constantin
authors: C
authors: Vlagioiu
authors: Nancy OIE/WHO/EU Laboratory for Rabies and Wildlife, French Agency for Food, Environmental and Occupational Health & Safety, Malzéville, France. Electronic address: florence.cliquet@anses.fr.
authors: Florence
authors: F
authors: Cliquet
mesh_terms: D000818:Animals; D001921:Brain / Q000821:virology*; D002417:Cattle / Q000821:virology*; D010802:Phylogeny; D012367:RNA, Viral / Q000302:isolation & purification; D011818:Rabies / Q000139:chemically induced*; D011819:Rabies Vaccines / Q000009:adverse effects*; D011820:Rabies virus / Q000235:genetics / Q000302:isolation & purification*; D012383:Romania; D014613:Vaccines, Attenuated / Q000009:adverse effects
chemical_list: D012367:RNA, Viral; D011819:Rabies Vaccines; D014613:Vaccines, Attenuated
keywords: Fox; Pathogenicity; Rabies; SAD B19; Sequencing; Vaccine