title: The Long-term Clinical Course of Chronic Eosinophilic Pneumonia.
abstract: Objective The long-term clinical course and prognosis of patients with chronic eosinophilic pneumonia (CEP) including factors predictive of the relapse of CEP have not been fully investigated. The aim of the present study was to investigate these issues. Methods We retrospectively investigated the rate of relapse and prognosis in 73 patients diagnosed as having CEP. Results Systemic corticosteroid therapy was administered at a prednisolone dose of 29.4±7.6 mg/day. During a median follow-up period of 1,939 days, 27 patients suffered from relapse of CEP. Two patients developed steroid-induced diabetes mellitus, and 1 patient developed pulmonary nontuberculous mycobacteriosis. Five patients died; however, none died of CEP. A history of smoking was the only independent negative risk factor for relapse of CEP [hazard ratio, 0.37 (0.14-0.98)]. Conclusion Patients with CEP frequently relapse. During the follow-up, metabolic and infectious complications under prolonged corticosteroid therapy are problematic. A history of smoking was a negative factor for predicting the risk of CEP relapse.
authors: Department of Respiratory Medicine, Saitama Cardiovascular and Respiratory Center, Japan.
authors: Takashi
authors: T
authors: Ishiguro
authors: Noboru
authors: N
authors: Takayanagi
authors: Ryuji
authors: R
authors: Uozumi
authors: Mami
authors: M
authors: Tada
authors: Naho
authors: N
authors: Kagiyama
authors: Yotaro
authors: Y
authors: Takaku
authors: Yoshihiko
authors: Y
authors: Shimizu
authors: Yutaka
authors: Y
authors: Sugita
authors: Satoshi
authors: S
authors: Morita
mesh_terms: D000328:Adult; D000368:Aged; D002908:Chronic Disease; D003920:Diabetes Mellitus / Q000139:chemically induced; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008875:Middle Aged; D009165:Mycobacterium Infections, Nontuberculous / Q000150:complications; D011239:Prednisolone / Q000627:therapeutic use; D011379:Prognosis; D011657:Pulmonary Eosinophilia / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy / Q000503:physiopathology*; D012008:Recurrence; D012189:Retrospective Studies; D012907:Smoking / Q000009:adverse effects
chemical_list: D005938:Glucocorticoids; D011239:Prednisolone