title: Prognostic impact of the 2016 WHO classification of diffuse gliomas in the French POLA cohort.
abstract: The new WHO classification of diffuse gliomas has been refined and now includes the 1p/19q codeletion, IDH1/2 mutation, and histone H3-K27M mutation. Our objective was to assess the prognostic value of the updated 2016 WHO classification in the French POLA cohort. All cases of high-grade oligodendroglial tumors sent for central pathological review and included into the French nationwide POLA cohort were reclassified according to the updated 4th WHO classification. In total, 1041 patients were included, with a median age at diagnosis of 50.4 years (range 17.1-84.4). Based on the new histomolecular classification, diagnoses included anaplastic oligodendroglioma IDH mutant and 1p/19q-codeleted (32.5 %), anaplastic astrocytoma IDH mutant (IDH (mut)) (11.0 %), anaplastic astrocytoma IDH wild type (IDH (wt)) (5.3 %), glioblastoma IDH (mut) (17.1 %), and glioblastoma IDH (wt) (33.2 %). Ten patients presented with a diffuse midline tumor, H3 K27M mutant. The new WHO classification was prognostic for progression-free survival (PFS) and overall survival (OS) (p < 0.001). We did not find prognosis differences between grades III and IV for IDH (mut) 1p/19q intact and IDH (wt) gliomas in univariate and multivariate analyses. Among anaplastic astrocytoma IDH (wt), cases with chromosome arm 7p gain and 10q loss (55 %) had shorter PFS than the others (p = 0.027). In conclusion, the new WHO histomolecular classification of diffuse gliomas presented with high prognostic value. Grading was not discriminant between grade III and IV high-grade gliomas.
authors: APHM, Hôpital de la Timone, Service de Neurooncologie, Marseille, France.|Aix-Marseille Université, Inserm, CRO2 UMR_S 911, Marseille, France.
authors: Emeline
authors: E
authors: Tabouret
authors: APHM, Hôpital de la Timone, Service d'Anatomie Pathologique et de Neuropathologie, Marseille, France.
authors: Anh Tuan
authors: AT
authors: Nguyen
authors: AP-HP, Hôpitaux Universitaires La Pitié Salpêtrière, Charles Foix, Service de Neurologie 2-Mazarin, 75013, Paris, France.
authors: Caroline
authors: C
authors: Dehais
authors: Inserm U1127, CNRS UMR 7225, Sorbonne Universités, UPMC Univ Paris 06 UMRS1127, Institut du Cerveau et de la Moelle épinière, ICM, 75013, Paris, France.
authors: Catherine
authors: C
authors: Carpentier
authors: Hospices Civils de Lyon, Hôpital Pierre Wertheimer, Service de Neurooncologie, Bron, France.|Department of Cancer Cell Plasticity, Cancer Research Centre of Lyon, INSERM U1052, CNRS UMR5286, Lyon, France.
authors: François
authors: F
authors: Ducray
authors: AP-HP, Hôpitaux Universitaires La Pitié Salpêtrière, Charles Foix, Service de Neurologie 2-Mazarin, 75013, Paris, France.|Inserm U1127, CNRS UMR 7225, Sorbonne Universités, UPMC Univ Paris 06 UMRS1127, Institut du Cerveau et de la Moelle épinière, ICM, 75013, Paris, France.
authors: Ahmed
authors: A
authors: Idbaih
authors: AP-HP, Hôpitaux Universitaires La Pitié Salpêtrière, Charles Foix, Service de Neurologie 2-Mazarin, 75013, Paris, France.|Inserm U1127, CNRS UMR 7225, Sorbonne Universités, UPMC Univ Paris 06 UMRS1127, Institut du Cerveau et de la Moelle épinière, ICM, 75013, Paris, France.|AP-HP, Groupe Hospitalier Pitié-Salpêtrière, Service de Neuropathologie Raymond Escourolle, Paris, France.
authors: Karima
authors: K
authors: Mokhtari
authors: Centre de pathologie et de neuropathologie Est, Bron, France.
authors: Anne
authors: A
authors: Jouvet
authors: CHU Toulouse, Hôpital Rangueil, Service d'Anatomie Pathologique et Histologie-Cytologie, Toulouse, France.|Inserm U1037, Centre de Recherche en Cancérologie de Toulouse, Université de Toulouse, Toulouse, France.
authors: Emmanuelle
authors: E
authors: Uro-Coste
authors: Aix-Marseille Université, Inserm, CRO2 UMR_S 911, Marseille, France.
authors: Carole
authors: C
authors: Colin
authors: APHM, Hôpital de la Timone, Service de Neurooncologie, Marseille, France.|Aix-Marseille Université, Inserm, CRO2 UMR_S 911, Marseille, France.
authors: Olivier
authors: O
authors: Chinot
authors: CHU Bordeaux, Hôpital Pellegrin, Service de Neurochirurgie, Bordeaux, France.
authors: Hugues
authors: H
authors: Loiseau
authors: Department of Radiation Oncology, Institut Claudius Regaud/Institut Universitaire du Cancer de Toulouse, Oncopôle, Toulouse, France.|Université Toulouse III Paul Sabatier, Toulouse, France.|INSERM U1037, Centre de Recherches contre le Cancer de Toulouse, Toulouse, France.
authors: Elisabeth
authors: E
authors: Moyal
authors: CHU Lille, Pôle Pathologie Biologique, Service Anatomie Pathologique, Lille, France.
authors: Claude-Alain
authors: CA
authors: Maurage
authors: AP-HP, Hôpital Lariboisière, Service d'Anatomie et Cytologie Pathologique, Paris, France.
authors: Marc
authors: M
authors: Polivka
authors: CHU Caen, Hôpital de la Côte de Nacre, Service d'anatomie Pathologique, Caen, France.|CNRS, UMR 6301 ISTCT, CERVOxy, GIP CYCERON, Caen, France.
authors: Emmanuèle
authors: E
authors: Lechapt-Zalcman
authors: CHU Amiens, Service de neurochirurgie, Hôpital Nord, Amiens, France.
authors: Christine
authors: C
authors: Desenclos
authors: Department of Cancer Cell Plasticity, Cancer Research Centre of Lyon, INSERM U1052, CNRS UMR5286, Lyon, France.|Centre de pathologie et de neuropathologie Est, Bron, France.
authors: David
authors: D
authors: Meyronet
authors: AP-HP, Hôpitaux Universitaires La Pitié Salpêtrière, Charles Foix, Service de Neurologie 2-Mazarin, 75013, Paris, France.|Inserm U1127, CNRS UMR 7225, Sorbonne Universités, UPMC Univ Paris 06 UMRS1127, Institut du Cerveau et de la Moelle épinière, ICM, 75013, Paris, France.
authors: Jean-Yves
authors: JY
authors: Delattre
authors: Aix-Marseille Université, Inserm, CRO2 UMR_S 911, Marseille, France. dominique.figarella-branger@univ-amu.fr.|APHM, Hôpital de la Timone, Service d'Anatomie Pathologique et de Neuropathologie, Marseille, France. dominique.figarella-branger@univ-amu.fr.
authors: Dominique
authors: D
authors: Figarella-Branger
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001254:Astrocytoma / Q000453:epidemiology* / Q000235:genetics; D001932:Brain Neoplasms / Q000453:epidemiology* / Q000235:genetics; D015331:Cohort Studies; D018572:Disease-Free Survival; D005260:Female; D005910:Glioma / Q000145:classification / Q000453:epidemiology* / Q000235:genetics; D006801:Humans; D008297:Male; D008875:Middle Aged; D009154:Mutation / Q000235:genetics; D009837:Oligodendroglioma / Q000453:epidemiology* / Q000235:genetics; D011379:Prognosis; D014944:World Health Organization; D055815:Young Adult
keywords: 1p/19q codeletion; 2016 WHO classification; Diffuse glioma; IDH1/2 mutation