title: Mutagenic activity of quaternary ammonium salt derivatives of carbohydrates.
abstract: This paper presents a study on a series of quaternary ammonium salt (QAS) derivatives of glucopyranosides with an elongated hydrophobic hydrocarbon chain. The new N-[6-(β-D-glucopyranosyloxy)hexyl]ammonium bromides and their O-acetyl derivatives were analyzed via (1)H and (13)C NMR spectroscopy. The mutagenic activity of the newly synthesized QAS was investigated using two different techniques: The Vibrio harveyi luminescence assay and the Ames test. The obtained results support previous findings contesting QAS safety and indicate that QAS, specifically pyridinium derivatives, might be mutagenic.
authors: Faculty of Chemistry, University of Gdańsk, Wita Stwosza 63, 80-308 Gdańsk, Poland.
authors: Barbara
authors: B
authors: Dmochowska
authors: Faculty of Chemistry, University of Gdańsk, Wita Stwosza 63, 80-308 Gdańsk, Poland; Faculty of Pharmacy, Medical University of Gdańsk, Gen. Hallera 107, 80-416 Gdańsk, Poland.
authors: Karol
authors: K
authors: Sikora
authors: Laboratory of Biophysics, Intercollegiate Faculty of Biotechnology, University of Gdańsk and Medical University of Gdańsk, Antoniego Abrahama 58, 80-307 Gdańsk, Poland.
authors: Anna
authors: A
authors: Woziwodzka
authors: Laboratory of Biophysics, Intercollegiate Faculty of Biotechnology, University of Gdańsk and Medical University of Gdańsk, Antoniego Abrahama 58, 80-307 Gdańsk, Poland.
authors: Jacek
authors: J
authors: Piosik
authors: Department of Molecular Evolution, University of Gdańsk, Wita Stwosza 59, 80-308 Gdańsk, Poland.
authors: Beata
authors: B
authors: Podgórska
keywords: 6-bromohexyl D-glucopyranoside; microbiological mutagenicity test; quaternary ammonium salt