title: Regulation of CTNNB1 signaling in gastric cancer and stem cells.
abstract: Recent research has shown that the alteration of combinations in gene expression contributes to cellular phenotypic changes. Previously, it has been demonstrated that the combination of cadherin 1 and cadherin 2 expression can identify the diffuse-type and intestinal-type gastric cancers. Although the diffuse-type gastric cancer has been resistant to treatment, the precise mechanism and phenotypic involvement has not been revealed. It may be possible that stem cells transform into gastric cancer cells, possibly through the involvement of a molecule alteration and signaling mechanism. In this review article, we focus on the role of catenin beta 1 (CTNNB1 or β-catenin) and describe the regulation of CTNNB1 signaling in gastric cancer and stem cells.
authors: Shihori Tanabe, Division of Risk Assessment, Biological Safety Research Center, National Institute of Health Science, Tokyo 158-8501, Japan.
authors: Shihori
authors: S
authors: Tanabe
authors: Shihori Tanabe, Division of Risk Assessment, Biological Safety Research Center, National Institute of Health Science, Tokyo 158-8501, Japan.
authors: Kazuhiko
authors: K
authors: Aoyagi
authors: Shihori Tanabe, Division of Risk Assessment, Biological Safety Research Center, National Institute of Health Science, Tokyo 158-8501, Japan.
authors: Hiroshi
authors: H
authors: Yokozaki
authors: Shihori Tanabe, Division of Risk Assessment, Biological Safety Research Center, National Institute of Health Science, Tokyo 158-8501, Japan.
authors: Hiroki
authors: H
authors: Sasaki
keywords: CTNNB1 signaling; Epithelial-mesenchymal transition; Gastric cancer; Stem cell; β-catenin