title: Patients, Here Comes More Nanotechnology.
abstract: We describe the current difference in reporting the performance of nanotechnology diagnostic devices between technologists and clinicians. This perspective specifies the "metrics" used to evaluate these devices and describes strategies to bridge the gap between these two communities in order to accelerate the translation from academic bench to the clinic. We use two recently published ACS Nano articles to highlight the evaluation of silicon nanowire and surface-enhanced Raman spectroscopy-breath diagnostic tests for patients afflicted with cancer and asthma. These studies represent some of the earliest studies of emerging nanotechnology devices utilizing clinical parameters to assess performance.
authors: Institute of Biomaterials and Biomedical Engineering, Donnelly Center for Biomolecular Research, Department of Chemistry, Department of Chemical Engineering, Department of Materials Science and Engineering, University of Toronto , 164 College St., Toronto, Ontario M5T 2R5, Canada.
authors: Warren C W
authors: WC
authors: Chan
authors: Institute of Biomaterials and Biomedical Engineering, Donnelly Center for Biomolecular Research, Department of Chemistry, Department of Chemical Engineering, Department of Materials Science and Engineering, University of Toronto , 164 College St., Toronto, Ontario M5T 2R5, Canada.
authors: Buddhisha
authors: B
authors: Udugama
authors: Institute of Biomaterials and Biomedical Engineering, Donnelly Center for Biomolecular Research, Department of Chemistry, Department of Chemical Engineering, Department of Materials Science and Engineering, University of Toronto , 164 College St., Toronto, Ontario M5T 2R5, Canada.
authors: Pranav
authors: P
authors: Kadhiresan
authors: Institute of Biomaterials and Biomedical Engineering, Donnelly Center for Biomolecular Research, Department of Chemistry, Department of Chemical Engineering, Department of Materials Science and Engineering, University of Toronto , 164 College St., Toronto, Ontario M5T 2R5, Canada.
authors: Jisung
authors: J
authors: Kim
authors: Sunnybrook Health Sciences Center , 2075 Bayview Ave., Toronto, Ontario M4N 3M5, Canada.
authors: Samira
authors: S
authors: Mubareka
authors: Paul S
authors: PS
authors: Weiss
authors: Fachbereich Physik, Philipps Universität Marburg , Marburg D-35032, Germany.|CIC biomaGUNE , Donostia-San Sebastián 20009, Spain.
authors: Wolfgang J
authors: WJ
authors: Parak
mesh_terms: D006801:Humans; D050997:Nanomedicine / Q000639:trends*; D036103:Nanotechnology; D053770:Nanowires; D009369:Neoplasms; D012825:Silicon; D013059:Spectrum Analysis, Raman
chemical_list: D012825:Silicon