title: Cytotoxicity of Triterpenoid Alkaloids from Buxus microphylla against Human Tumor Cell Lines.
abstract: Three new triterpenoid alkaloids, namely buxmicrophyllines P-R (1-3), were isolated from the twigs and leaves of Buxus microphylla. Their structures were elucidated on the basis of NMR and MS spectroscopic analyses. Structurally, compounds 1-3 belong to the 9,10-cycloartane type alkaloids. In addition, compound 3 exhibited moderate cytotoxic activities in vitro against HL-60, SMMC-7221, A-549, MCF-7, and SW480 cell lines (with IC50 values ranging from 4.51 to 15.58 μM).
authors: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China. baisitou@126.com.|School of Traditional Chinese Medicine, Yunnan University of Traditional Chinese Medicine, Kunming 650500, China. baisitou@126.com.
authors: Shi-Tou
authors: ST
authors: Bai
authors: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China. zhuguolei@mail.kib.ac.cn.
authors: Guo-Lei
authors: GL
authors: Zhu
authors: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China. pengxingrong@mail.kib.ac.cn.|Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China. pengxingrong@mail.kib.ac.cn.
authors: Xing-Rong
authors: XR
authors: Peng
authors: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China. dongjinrun@mail.kib.ac.cn.|Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China. dongjinrun@mail.kib.ac.cn.
authors: Jin-Run
authors: JR
authors: Dong
authors: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China. yumuyuan@mail.kib.ac.cn.
authors: Mu-Yuan
authors: MY
authors: Yu
authors: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China. jcchen@mail.kib.ac.cn.|School of Traditional Chinese Medicine, Yunnan University of Traditional Chinese Medicine, Kunming 650500, China. jcchen@mail.kib.ac.cn.|Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China. jcchen@mail.kib.ac.cn.
authors: Jian-Chao
authors: JC
authors: Chen
authors: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China. wanlesheng1@163.com.|Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China. wanlesheng1@163.com.
authors: Luo-Sheng
authors: LS
authors: Wan
authors: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China. mhchiu@mail.kib.ac.cn.|School of Traditional Chinese Medicine, Yunnan University of Traditional Chinese Medicine, Kunming 650500, China. mhchiu@mail.kib.ac.cn.|Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China. mhchiu@mail.kib.ac.cn.
authors: Ming-Hua
authors: MH
authors: Qiu
mesh_terms: D000072283:A549 Cells; D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D031235:Buxus / Q000737:chemistry*; D003603:Cytotoxins / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D018922:HL-60 Cells; D006801:Humans; D061986:MCF-7 Cells; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology
chemical_list: D000470:Alkaloids; D000972:Antineoplastic Agents, Phytogenic; D003603:Cytotoxins; D014315:Triterpenes
keywords: Buxus microphylla; cytotoxicity; triterpenoid alkaloid