title: [Predictive value of c-met for long-term mortality in patients with esophageal squamous cell carcinoma].
abstract: OBJECTIVE
  To explore the correlation of c-met protein with the clinical staging and cell differentiation of esophageal squamous cell carcinoma (ESCC).
  
  
  METHODS
  A total of 100 patients with ESCC were enrolled were examined for expression of c-met protein using immunohistochemistry, and the patients in negative and positive c-met expression groups were compared for clinicopathological characteristics and overall survival.
  
  
  RESULTS
  s The 100 ESCC patients included 67 male and 33 female patients with a median age of 59 years; 49 of the patients were negative and 51 were positive for c-met expression. Positive c-met expression was significantly correlated with advanced TMN stages and lower tumor differentiation. Kaplan-Meier survival curve showed that the median survival time of c-met-positive patients was significantly reduced compared with that of c-met-negative patients (30.9 vs 48.2 months, P<0.05). COX regression analysis showed that c-met was a independent risk factor for the overall survival of the patients (HR: 2.34, 95% CI: 1.63-4.54, P<0.05).
  
  
  CONCLUSIONS
  A positive expression of c-met protein is significantly correlated with an advanced TMN stage, lower tumor differentiation and a poor prognosis, and may serve as a indicator for predicting the prognosis of ESCC.
authors: 1Southern Medical University, Guangzhou 5100515, China; 2Department of Thoracic Surgery, Guangdong General Hospital/Guangdong Academy of Medical Sciences, Guangzhou 510080, China. E-mail: joeshope@hotmail.com.
authors: Zi-Hao
authors: ZH
authors: Zhou
authors: Gang
authors: G
authors: Chen
authors: Zhi
authors: Z
authors: Xie
authors: Ji-Ming
authors: JM
authors: Tang
authors: Xiao-Song
authors: XS
authors: Ben
authors: Liang
authors: L
authors: Xie
authors: Hai-Yu
authors: HY
authors: Zhou
authors: Dong-Kun
authors: DK
authors: Zhang
authors: Xiong
authors: X
authors: Ye
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000175:diagnosis* / Q000378:metabolism; D004938:Esophageal Neoplasms / Q000175:diagnosis* / Q000378:metabolism; D000077277:Esophageal Squamous Cell Carcinoma; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011379:Prognosis; D016016:Proportional Hazards Models; D019859:Proto-Oncogene Proteins c-met / Q000378:metabolism*; D012307:Risk Factors
chemical_list: D019859:Proto-Oncogene Proteins c-met