title: Does the Routine Availability of CT-Derived FFR Influence Management of Patients With Stable Chest Pain Compared to CT Angiography Alone?: The FFRCTRIPCORD Study.
abstract: This study sought to determine the effect of adding computed tomography-derived fractional flow reserve (FFRCT) data to computed tomography angiographic (CTA) data alone for assessment of lesion severity and patient management in 200 patients with chest pain.
  
  
  
  Invasive and noninvasive tests used in the assessment of patients with angina all have disadvantages. The ideal screening test for patients presenting for the first time with chest pain would describe both coronary anatomy and the presence of ischemia and would be readily accessible, low cost, and noninvasive.
  
  
  
  Two hundred patients with stable chest pain underwent CTA for clinical reasons, and FFRCTwas calculated. Three experienced interventional cardiologists assessed the CTA result for each patient and by consensus developed a management plan (optimal medical therapy, percutaneous coronary intervention, coronary artery bypass graft surgery, or more information required). FFRCTdata for each vessel were then revealed, and the interventional cardiologists made a second plan by consensus, using the same 4 options. The primary endpoint for the study was the difference between the 2 strategies.
  
  
  
  Overall, after disclosure of FFRCTdata there was a change in the allocated management category on the basis of CTA alone in 72 cases (36%). This difference is explained by a discordance between the CTA- and FFRCT-derived assessments of lesion severity. For example, FFRCTwas >0.80 in 13 of 44 vessels (29.5%) graded as having a stenosis >90%. In contrast, FFRCTwas ≤0.80 in 17 of 366 vessels (4.6%) graded as having stenosis ≤50%.
  
  
  
  This study demonstrates proof of concept that the availability of FFRCTresults has a substantial effect on the labeling of significant coronary artery disease and therefore on the management of patients compared to CTA alone. Further studies are needed to determine whether FFRCThas potential as a noninvasive diagnostic and management screening tool for patients with stable chest pain.
authors: University Hospital Southampton & Faculty of Medicine, University of Southampton, Southampton, United Kingdom. Electronic address: nick.curzen@uhs.nhs.uk.
authors: Nicholas P
authors: NP
authors: Curzen
authors: University Hospitals of North Staffordshire, Stoke-on-Trent, United Kingdom.
authors: James
authors: J
authors: Nolan
authors: Freeman Hospital, and Institute of Cellular Medicine Newcastle University, Newcastle upon Tyne, United Kingdom.
authors: Azfar G
authors: AG
authors: Zaman
authors: Aarhus University Hospital Skejby, Aarhus, Denmark.
authors: Bjarne L
authors: BL
authors: Nørgaard
authors: Guy's & St. Thomas' Hospital, London, United Kingdom.
authors: Ronak
authors: R
authors: Rajani
mesh_terms: D060050:Angina, Stable / Q000000981:diagnostic imaging* / Q000209:etiology / Q000503:physiopathology / Q000628:therapy; D000072226:Computed Tomography Angiography; D017023:Coronary Angiography / Q000379:methods*; D003324:Coronary Artery Disease / Q000150:complications / Q000000981:diagnostic imaging* / Q000503:physiopathology / Q000628:therapy; D003331:Coronary Vessels / Q000000981:diagnostic imaging* / Q000503:physiopathology; D053805:Fractional Flow Reserve, Myocardial; D006801:Humans; D011237:Predictive Value of Tests; D011379:Prognosis; D012720:Severity of Illness Index
keywords: chest pain; computed tomography angiography; computed tomography–derived fractional flow reserve