title: A Thalamocortical Neural Mass Model of the EEG during NREM Sleep and Its Response to Auditory Stimulation.
abstract: Few models exist that accurately reproduce the complex rhythms of the thalamocortical system that are apparent in measured scalp EEG and at the same time, are suitable for large-scale simulations of brain activity. Here, we present a neural mass model of the thalamocortical system during natural non-REM sleep, which is able to generate fast sleep spindles (12-15 Hz), slow oscillations (<1 Hz) and K-complexes, as well as their distinct temporal relations, and response to auditory stimuli. We show that with the inclusion of detailed calcium currents, the thalamic neural mass model is able to generate different firing modes, and validate the model with EEG-data from a recent sleep study in humans, where closed-loop auditory stimulation was applied. The model output relates directly to the EEG, which makes it a useful basis to develop new stimulation protocols.
authors: Institute for Neuro- and Bioinformatics, University of Lübeck, Lübeck, Germany.|Institute for Medical Psychology and Behavioral Neurobiology, University of Tübingen, Tübingen, Germany.
authors: Michael
authors: M
authors: Schellenberger Costa
authors: Institute for Neuro- and Bioinformatics, University of Lübeck, Lübeck, Germany.|Graduate School for Computing in Medicine and Life Science, University of Lübeck, Lübeck, Germany.
authors: Arne
authors: A
authors: Weigenand
authors: Institute for Medical Psychology and Behavioral Neurobiology, University of Tübingen, Tübingen, Germany.
authors: Hong-Viet V
authors: HV
authors: Ngo
authors: Graduate School for Computing in Medicine and Life Science, University of Lübeck, Lübeck, Germany.|Institute of Experimental and Clinical Pharmacology and Toxicology, University of Lübeck, Lübeck, Germany.
authors: Lisa
authors: L
authors: Marshall
authors: Institute for Medical Psychology and Behavioral Neurobiology, University of Tübingen, Tübingen, Germany.|Center for Integrative Neuroscience, University of Tübingen, Tübingen, Germany.
authors: Jan
authors: J
authors: Born
authors: Institute for Neuro- and Bioinformatics, University of Lübeck, Lübeck, Germany.|Graduate School for Computing in Medicine and Life Science, University of Lübeck, Lübeck, Germany.
authors: Thomas
authors: T
authors: Martinetz
authors: Institute for Neuro- and Bioinformatics, University of Lübeck, Lübeck, Germany.|Computational Systems Biology, Jacobs University Bremen, Bremen, Germany.
authors: Jens Christian
authors: 0000-0002-9870-4924
authors: JC
authors: Claussen
mesh_terms: D000161:Acoustic Stimulation; D002540:Cerebral Cortex / Q000502:physiology*; D004569:Electroencephalography; D006801:Humans; D008959:Models, Neurological; D012890:Sleep / Q000502:physiology*; D013788:Thalamus / Q000502:physiology*