title: Heat acclimation and cross tolerance to hypoxia: Bridging the gap between cellular and systemic responses.
abstract: Recent research has suggested a potential for some of the physiological and cellular responses to heat acclimation to carry over to improved tolerance of the novel stresses of another environment. This cross-tolerance is evident in heat-acclimated animals that exhibit enhanced tolerance to either hypoxic or ischemic stress, and is primarily attributed to shared cellular stress response pathways. These pathways include Hypoxia-Inducible Factor-1 (HIF-1) and Heat Shock Proteins (HSP). Whether these shared cellular stress response pathways translate to systemic cross-tolerance (improved exercise tolerance, reduced risk of environment-associated illness) has not been clearly shown, particularly in humans. This review highlights the HIF-1 and HSP pathways and their relationship with systemic acclimation responses, and further examines the potential cellular and systemic adaptations that may result in cross-tolerance between hot and hypoxic environments.
authors: University of Oregon; Department of Human Physiology; Eugene, OR USA.
authors: Brett R
authors: BR
authors: Ely
authors: University of Oregon; Department of Human Physiology; Eugene, OR USA.
authors: Andrew T
authors: AT
authors: Lovering
authors: The Hebrew University of Jerusalem; Laboratory of Environmental Physiology; Faculty of Dental Medicine; Jerusalem, Israel.
authors: Michal
authors: M
authors: Horowitz
authors: University of Oregon; Department of Human Physiology; Eugene, OR USA.
authors: Christopher T
authors: CT
authors: Minson
keywords: heat acclimation; heat shock protein; high altitude acclimatization; hypoxia-inducible factor