title: A prospective hospital study of alcohol use disorders, comorbid psychiatric conditions and withdrawal prognosis.
abstract: BACKGROUND
  The objective of this study was to describe the profile and alcoholic status of a population with alcohol use disorders (AUD) requesting help from a psychiatric hospital to stop drinking, as well as their clinical outcome and care consumption over the 2 years following the request.
  
  
  METHODS
  The visits were conducted at baseline (M0) and at 6, 12, 18 and 24 months (M6, M12, M18, M24). Demographic, clinical and psychometric data [Beck Depression Inventory (BDI), AUDIT questionnaire, Global Assessment of Functioning (GAF) scale], and information regarding the use of psychiatric care and therapeutics were collected.
  
  
  RESULTS
  The 330 subjects included were mostly male, aged 45.2 ± 10.2 years with an employment rate of 55.4 %, living alone (69.1 %), with a psychiatric comorbidity (60.9 %), especially depressive, and with few somatic complications. Their global functioning was poor (GAF score 49.14 ± 15.6), and less than 10 % were addicted to another substance. The abstinence rate at 24 months was 41.4 %, but only 23 % (20) abstained continuously between M0 and M24, and 66.7 % (58) intermittently. The likelihood of abstinence at M24 was greater for females aged over 60 years. The BDI score decreased significantly between M0 and M24. In all, 56.2 % of the participants were re-hospitalized after weaning, but were not integrated in long-term medical care.
  
  
  CONCLUSIONS
  Abstinence after alcohol withdrawal fluctuated over time indicating the need for long-term support. The treatment of AUD should not target total, continuous abstinence. Prognostic profiles combining socio-demographic, clinical and biological indicators must be established.
authors: Pôle Addictologie, Centre Hospitalier Esquirol, 15 rue du Dr Marcland, 87025 Limoges, France ; Département de Recherche et Développement (DRD), Centre Hospitalier Esquirol, 87025 Limoges, France ; Faculté de Médecine, UMR/INSERM1094, 2 rue du Dr Marcland, 87025 Limoges, France.
authors: Philippe
authors: P
authors: Nubukpo
authors: Département de Recherche et Développement (DRD), Centre Hospitalier Esquirol, 87025 Limoges, France.
authors: Murielle
authors: M
authors: Girard
authors: Pôle de Psychiatrie Infanto Juvénile, Centre Hospitalier Esquirol, 87025 Limoges, France.
authors: Jean-Marie
authors: JM
authors: Sengelen
authors: Pôle de Psychiatrie Adulte, Centre Hospitalier Esquirol, 87025 Limoges, France.
authors: Sophie
authors: S
authors: Bonnefond
authors: Pôle de Psychiatrie Adulte, Centre Hospitalier Esquirol, 87025 Limoges, France.
authors: Aurélien
authors: A
authors: Varnoux
authors: Faculté de Médecine, UMR/INSERM1094, 2 rue du Dr Marcland, 87025 Limoges, France.
authors: Benoît
authors: B
authors: Marin
authors: Département de Recherche et Développement (DRD), Centre Hospitalier Esquirol, 87025 Limoges, France.
authors: Dominique
authors: D
authors: Malauzat
keywords: Abstinence; Alcohol; Comorbidity; Psychiatric care; Psychiatry; Withdrawal