title: Adrenocortical Expression Profiling of Cattle with Distinct Juvenile Temperament Types.
abstract: Temperament affects ease of handling, animal welfare, and economically important production traits in cattle. The use of gene expression profiles as molecular traits provides a novel means of gaining insight into behavioural genetics. In this study, differences in adrenocortical expression profiles between 60 F2cows (Charolais × German Holstein) of distinct temperament types were analysed. The cows were assessed in a novel-human test at an age of 90 days. Most of the adrenal cortex transcripts which were differentially expressed (FDR <0.05) were found between temperament types of 'fearful/neophobic-alert' and all other temperament types. These transcripts belong to several biological functions like NRF2-mediated oxidative stress response, Glucocorticoid Receptor Signalling and Complement System. Overall, the present study provides new insight into transcriptional differences in the adrenal cortex between cows of distinct temperament types. Genetic regulations of such molecular traits facilitate uncovering positional and functional gene candidates for temperament type in cattle.
authors: Institute for Farm Animal Research and Technology, University of Rostock, Rostock, Germany.
authors: Juliane
authors: J
authors: Friedrich
authors: Institute for Genome Biology, Leibniz Institute for Farm Animal Biology, Wilhelm-Stahl-Allee 2, 18196, Dummerstorf, Germany.
authors: Bodo
authors: B
authors: Brand
authors: Institute for Behavioural Physiology, Leibniz Institute for Farm Animal Biology, Dummerstorf, Germany.
authors: Katharina Luise
authors: KL
authors: Graunke
authors: Institute for Behavioural Physiology, Leibniz Institute for Farm Animal Biology, Dummerstorf, Germany.
authors: Jan
authors: J
authors: Langbein
authors: Institute for Farm Animal Research and Technology, University of Rostock, Rostock, Germany.|Institute for Genome Biology, Leibniz Institute for Farm Animal Biology, Wilhelm-Stahl-Allee 2, 18196, Dummerstorf, Germany.
authors: Manfred
authors: M
authors: Schwerin
authors: Institute for Genome Biology, Leibniz Institute for Farm Animal Biology, Wilhelm-Stahl-Allee 2, 18196, Dummerstorf, Germany. s.wimmers@fbn-dummerstorf.de.
authors: Siriluck
authors: http://orcid.org/0000-0003-4714-1057
authors: S
authors: Ponsuksili
mesh_terms: D000302:Adrenal Cortex / Q000378:metabolism*; D000818:Animals; D001522:Behavior, Animal; D002417:Cattle; D016000:Cluster Analysis; D003345:Corticosterone / Q000378:metabolism; D005260:Female; D020869:Gene Expression Profiling; D006854:Hydrocortisone / Q000378:metabolism; D008297:Male; D013694:Temperament
chemical_list: D003345:Corticosterone; D006854:Hydrocortisone
keywords: Adrenal cortex; Cattle; Gene expression; Stress; Temperament