title: Total antioxidant, total oxidant and serum paraoxonase levels according to lipid administration method in parenterally fed premature infants.
abstract: OBJECTIVE
  The aim of our study was to determine whether lipid solutions delivered separately or in mixture with total parenteral nutrition (TPN) solutions effect the balance between oxidant and antioxidant levels in premature infants.
  
  
  METHODS
  A total of 60 preterm newborns who were delivered at their 30-34 gestational weeks and received TPN were included in the study. Premature newborns were randomized into two groups based on the delivery method of the lipid solution, separately (Group 1) or in mixture with TPN solutions (Group 2). Total antioxidant status (TAS), total oxidant status (TOS) and paraoxonase (PON-1) levels were analyzed in both blood samples, and oxidative stress index (OSI) was also calculated.
  
  
  RESULTS
  Thirty cases from both groups were included in the study. Statistically significant decrease in the level of TAS and increase in the level of PON-1 were detected at 72 h of TPN therapy in both groups (p < 0.05). Statistically significant decrease in both TOS and OSI levels were observed in Group 2 (p < 0.05). In association with these findings, any statistically significant intergroup difference was not detected in both parameters regarding oxidant balance (p > 0.05).
  
  
  CONCLUSIONS
  Our study showed that according to lipid administration method any difference for oxidant-antioxidant balance was not detected.
authors: a Division of Neonatology , Department of Pediatrics, Konya Education and Research Hospital , Konya , Turkey.
authors: Murat
authors: M
authors: Konak
authors: b Department of Neonatology , Meram Medical Faculty, Necmettin Erbakan University , Konya , Turkey.
authors: Nuriye
authors: N
authors: Tarakci
authors: b Department of Neonatology , Meram Medical Faculty, Necmettin Erbakan University , Konya , Turkey.
authors: Hüseyin
authors: H
authors: Altunhan
authors: c Department of Pediatri , Selcuk University, Selçuklu Medical Faculty , Konya , Turkey , and.
authors: Ali
authors: A
authors: Annagür
authors: d Department of Biochemistry , Meram Medical Faculty, Necmettin Erbakan University , Konya , Turkey.
authors: Aysun
authors: A
authors: Toker
authors: b Department of Neonatology , Meram Medical Faculty, Necmettin Erbakan University , Konya , Turkey.
authors: Rahmi
authors: R
authors: Örs
mesh_terms: D000328:Adult; D000975:Antioxidants / Q000378:metabolism*; D043303:Aryldialkylphosphatase / Q000097:blood*; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature / Q000097:blood*; D008055:Lipids / Q000008:administration & dosage*; D008297:Male; D018384:Oxidative Stress; D010288:Parenteral Nutrition / Q000379:methods*; D055815:Young Adult
chemical_list: D000975:Antioxidants; D008055:Lipids; D043303:Aryldialkylphosphatase; C468406:PON1 protein, human
keywords: Premature; lipid method; oxidant status; parenteral nutrition