title: Synergistic chiral iminium and palladium catalysis: Highly regio- and enantioselective [3 + 2] annulation reaction of 2-vinylcyclopropanes with enals.
abstract: A cooperative catalytic strategy of chiral iminium catalysis by regioselective activation of the C=C bond in enals and a transition metal promoting to open the 2-vinylcyclopropanes for highly regio- and enantioselective [3 + 2] cycloaddition reaction of 2-vinylcyclopropanes with α,β-unsaturated aldehydes has been developed.
authors: State Key Laboratory of Bioengineering Reactor, Shanghai Key Laboratory of New Drug Design and School of Pharmacy, East China University of Science and Technology, 130 Mei-long Road, Shanghai 200237, China; Department of Chemistry, Shanghai Normal University, Shanghai 200234, China.
authors: Haipan
authors: H
authors: Zhu
authors: Department of Chemistry, Shanghai Normal University, Shanghai 200234, China.
authors: Peile
authors: P
authors: Du
authors: State Key Laboratory of Bioengineering Reactor, Shanghai Key Laboratory of New Drug Design and School of Pharmacy, East China University of Science and Technology, 130 Mei-long Road, Shanghai 200237, China.
authors: Jianjun
authors: J
authors: Li
authors: State Key Laboratory of Bioengineering Reactor, Shanghai Key Laboratory of New Drug Design and School of Pharmacy, East China University of Science and Technology, 130 Mei-long Road, Shanghai 200237, China.
authors: Ziyang
authors: Z
authors: Liao
authors: Department of Chemistry, Shanghai Normal University, Shanghai 200234, China.
authors: Guohua
authors: G
authors: Liu
authors: State Key Laboratory of Bioengineering Reactor, Shanghai Key Laboratory of New Drug Design and School of Pharmacy, East China University of Science and Technology, 130 Mei-long Road, Shanghai 200237, China.
authors: Hao
authors: H
authors: Li
authors: State Key Laboratory of Bioengineering Reactor, Shanghai Key Laboratory of New Drug Design and School of Pharmacy, East China University of Science and Technology, 130 Mei-long Road, Shanghai 200237, China; Department of Chemistry and Chemical Biology, University of New Mexico, Albuquerque, NM 87131-0001, USA.
authors: Wei
authors: W
authors: Wang
keywords: [3 + 2] annulation; enals; synergistic catalysis; vinylcyclopropanes