title: Sequential Addition Reaction of Sulfanylmethyllithiums and Grignard Reagents to Thioformamides Leading to the Formation of 2-Phenyl-2-sulfanylethyl Tertiary Amines.
abstract: The reaction of sulfanylmethyllithiums generated from benzylsulfanes and n-BuLi with N,N-dimethylthioformamide followed by the addition of Grignard reagents gave 2-phenyl-2-sulfanyl tertiary amines in moderate to good yields. A range of Grignard reagents involving primary alkyl, aryl, vinyl, and alkynyl Grignard reagents were used. Two carbon-carbon bond-forming reactions were achieved through a one-pot reaction. The reaction showed good to high diastereoselectivity, particularly with alkynyl Grignard reagents.
authors: Department of Chemistry and Biomolecular Science, Faculty of Engineering, Gifu University , Yanagido, Gifu 501-1193, Japan.
authors: Toshiaki
authors: T
authors: Murai
authors: Department of Chemistry and Biomolecular Science, Faculty of Engineering, Gifu University , Yanagido, Gifu 501-1193, Japan.
authors: Natsumi
authors: N
authors: Mutoh