title: Comparison of three different doses sugammadex based on ideal body weight for reversal of moderate rocuronium-induced neuromuscular blockade in laparoscopic bariatric surgery.
abstract: BACKGROUND
  The majority of authors and the literature recommend sugammadex dose to be calculated according to RBW without taking fat content into consideration. Our aim was to compare the efficacy and safety of sugammadex at doses of 1.5, 2, and 4 mg/kg, calculated according to ideal body weight basis, for the reversal of moderate rocuronium-induced neuromuscular blockade in laparoscopic bariatric surgery.
  
  
  METHODS
  One-hundred and eighty morbidly obese patients were randomly assigned into three groups according to sugammadex dose administrated (based on IBW after reaching T2 of TOF): Group I: patients were given 1.5 mg/kg. Group II: patients were given 2 mg/kg. Group III: patients were given 4 mg/kg. Both sugammadex and extubation times were recorded.
  
  
  RESULTS
  Sugammadex time was significantly longer in groups I and II versus III (P=0.000, 0.005 respectively). Difference between groups I and II was insignificant. The extubation time was insignificantly different in the three groups (P>0.05).
  
  
  CONCLUSIONS
  A dose of sugammadex of 1.5 mg/kg calculated according to IBW successfully reversed moderate rocuronium-induced NMB in laparoscopic bariatric surgeries.
authors: Department of Anesthesia, ICU and Pain Relief, South Egypt Cancer Institute, Assiut University, Assiut, Egypt.
authors: Ahmad M
authors: AM
authors: Abd El-Rahman
authors: Department of Anesthesia, ICU and Pain Relief, South Egypt Cancer Institute, Assiut University, Assiut, Egypt.
authors: Ahmed H
authors: AH
authors: Othman
authors: Department of Anesthesia, ICU and Pain Relief, South Egypt Cancer Institute, Assiut University, Assiut, Egypt - fatma_anesthesia@yahoo.com.
authors: Fatma A
authors: FA
authors: El Sherif
authors: Department of Anesthesia and Intensive Care, Faculty of Medicine, Assiut University, Assiut, Egypt.
authors: Mohamed F
authors: MF
authors: Mostafa
authors: Department of Plastic Surgery, Faculty of Medicine, Assiut University, Assiut, Egypt.
authors: Osama
authors: O
authors: Taha
mesh_terms: D000293:Adolescent; D000328:Adult; D050110:Bariatric Surgery / Q000379:methods*; D005260:Female; D006801:Humans; D056865:Ideal Body Weight; D010535:Laparoscopy; D008297:Male; D008875:Middle Aged; D019148:Neuromuscular Blockade / Q000379:methods*; D003473:Neuromuscular Nondepolarizing Agents / Q000627:therapeutic use*; D009767:Obesity, Morbid / Q000601:surgery*; D000077123:Rocuronium / Q000627:therapeutic use*; D000077122:Sugammadex / Q000008:administration & dosage*; D055815:Young Adult
chemical_list: D003473:Neuromuscular Nondepolarizing Agents; D000077122:Sugammadex; D000077123:Rocuronium