title: Evaluating Pharmacological Effects of Two Major Components of Shuangdan Oral Liquid: Role of Danshensu and Paeonol in Diabetic Nephropathy Rat.
abstract: Shuangdan oral liquid (SDO) containing radix Salviae miltiorrhizae (Chinese name Danshen) and cortex moutan (Chinese name Mudanpi) is a traditional Chinese medicine using for treating vascular diseases. Danshensu (DSS) is a main effective monomer composition derived from radix Salviae miltiorrhizae and paeonol (Pae) from cortex moutan. Although the two herbs are widely used in traditional Chinese medicine, the pharmacological functions of their active compositions were not reported. Therefore, the research of DSS and Pae in mechanisms and pharmacodynamics interaction can provide scientific evidence to support clinical application. The diabetic nephropathy (DN) rats which were induced by streptozotocin (STZ) were treated with SDO, DSS, Pae, and DSS+Pae for eight weeks. The positive effects on DN animal models were investigated by detection of physiological and biochemical indexes and oxidative stress markers, within five treatments: SDO, DSS, Pae, DSS+Pae and insulin group. Compared with the model group, the DSS+Pae group improved the renal function, blood lipid metabolism and blood viscosity, increased the vitality of T-SOD or T-AOC and decreased the level of MDA or NO after the treatment. The study was successfully showed that the DSS+Pae group could delay the process of DN, especially in the renal injury part of histopathology changes. Our results suggest that the co-administration of DSS and Pae significantly may play a protective role in DN rats through decreasing the oxidative stress and improving the blood lipid metabolism mechanisms.
authors: Department of Natural Medicine, School of Pharmacy, Fourth Military Medical University, Xi'an 710032, China.|Collaborative Innovation Center for Chinese Medicine in Qinba Moutains, 169 West Changle Road, Xi'an 710032, China.
authors: Ying
authors: Y
authors: Chen
authors: State Key Laboratory of Military Stomatology, Department of Orthodontics, School of Stomatology, Fourth Military Medical University, Xi'an 710032, China.
authors: Zhuying
authors: Z
authors: Liu
authors: Department of Gynecology and Obstetrics, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, China.
authors: Fuxing
authors: F
authors: Zhou
authors: Department of Natural Medicine, School of Pharmacy, Fourth Military Medical University, Xi'an 710032, China.|Collaborative Innovation Center for Chinese Medicine in Qinba Moutains, 169 West Changle Road, Xi'an 710032, China.
authors: Hang
authors: H
authors: Zhao
authors: Department of Natural Medicine, School of Pharmacy, Fourth Military Medical University, Xi'an 710032, China.|Collaborative Innovation Center for Chinese Medicine in Qinba Moutains, 169 West Changle Road, Xi'an 710032, China.
authors: Qian
authors: Q
authors: Yang
authors: Department of Natural Medicine, School of Pharmacy, Fourth Military Medical University, Xi'an 710032, China.|Collaborative Innovation Center for Chinese Medicine in Qinba Moutains, 169 West Changle Road, Xi'an 710032, China.
authors: Hua
authors: H
authors: Li
authors: Department of Natural Medicine, School of Pharmacy, Fourth Military Medical University, Xi'an 710032, China.|Collaborative Innovation Center for Chinese Medicine in Qinba Moutains, 169 West Changle Road, Xi'an 710032, China.
authors: Jiyuan
authors: J
authors: Sun
authors: Department of Natural Medicine, School of Pharmacy, Fourth Military Medical University, Xi'an 710032, China.|Collaborative Innovation Center for Chinese Medicine in Qinba Moutains, 169 West Changle Road, Xi'an 710032, China.
authors: Siwang
authors: S
authors: Wang
keywords: Blood lipid metabolism; Danshensu; Diabetic nephropathy; Histopathology; Oxidative stress; Paeonol