title: The comparison between modified kligman formulation versus kligman formulation and intense pulsed light in the treatment of the post-burn hyperpigmentation.
abstract: BACKGROUND
  Post inflammatory hyperpigmentation (PIH) is a common problem occurs following many dermatologic diseases and medical interventions. Different modalities including topical agents, lasers and intense pulsed light (IPL) are suggested for treatment of the post-burn PIH. In the current study, we evaluated the efficacy of IPL plus modified Kligman cream (MODIFIED KLIGMAN CREAM) versus MODIFIED KLIGMAN CREAM alone in the treatment of the post-burn PIH.
  
  
  METHODS
  This was a randomized, non-blinded clinical trial. A total of 53 patches of post-burn PIP in 14 patients were randomized to receive either two sessions of IPL plus modified Kligman formula or kligman formula for 2 months. The patients were recommended to apply MODIFIED KLIGMAN CREAM cream for 12 h at night.
  
  
  RESULTS
  According to our results, the patients in the MODIFIED KLIGMAN CREAM + IPL group had higher satisfaction as compared with MODIFIED KLIGMAN CREAM alone (P = 0.000) (Mann-Whitney test). In addition, according to physician evaluation, the patients in the MODIFIED KLIGMAN CREAM + IPL group had higher satisfaction as compared with MODIFIED KLIGMAN CREAM alone (P = 0.000) (Mann-Whitney test). No side effects except a little irritation, erythema and exfoliation due to MODIFIED KLIGMAN CREAM cream were seen in the patients.
  
  
  CONCLUSIONS
  The results of our study showed the better efficacy and faster response of the IPL plus modified Kligman formula versus modified Kligman formula in the treatment of the post-burn PIH. To better determine the efficacy of IPL in treatment of the post-burn PIP, more extensive studies as randomized, double-blinded clinical trial are recommended.
authors: Department of Dermatology, Skin Diseases and Leishmaniasis Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
authors: Amir Hossein
authors: AH
authors: Siadat
authors: Department of Dermatology, Skin Diseases and Leishmaniasis Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
authors: Fariba
authors: F
authors: Iraji
authors: Department of Pathology, Isfahan University of Medical Sciences, Isfahan, Iran.
authors: Reza
authors: R
authors: Bahrami
authors: Skin and Stem cell Research Center, Tehran University of Medical Sciences, Tehran, Iran.
authors: Mohammad Ali
authors: MA
authors: Nilfroushzadeh
authors: Department of Dermatology, Skin Diseases and Leishmaniasis Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
authors: Ali
authors: A
authors: Asilian
authors: Department of Pathology, Isfahan University of Medical Sciences, Isfahan, Iran.
authors: Sheila
authors: S
authors: Shariat
authors: Department of Dermatology, Skin Diseases and Leishmaniasis Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
authors: Zahra
authors: Z
authors: Nikyar
authors: Department of Pathology, Isfahan University of Medical Sciences, Isfahan, Iran.
authors: Safura
authors: S
authors: Bokaie
keywords: Burn; hyperpigmentation; intense pulsed light