title: Adult age differences in subcortical myelin content are consistent with protracted myelination and unrelated to diffusion tensor imaging indices.
abstract: Post mortem studies suggest protracted myelination of subcortical white matter into the middle age followed by gradual decline in the late adulthood. To date, however, establishing the proposed inverted-U pattern of age-myelin association proved difficult, as the most common method of investigating white matter, diffusion tensor imaging (DTI), usually reveals only linear associations between DTI indices and age among healthy adults. Here we use a novel method of estimating Myelin Water Fraction (MWF) based on modeling the short spin-spin (T2) relaxation component from multi-echo T2relaxation imaging data and assess subcortical myelin content within six white matter tracts in a sample of healthy adults (N=61, age 18-84 years). Myelin content evidenced a quadratic relationship with age, in accord with the pattern observed postmortem studies. In contrast, DTI-derived indices that are frequently cited as proxies for myelination, fractional anisotropy (FA) and radial diffusivity (RD), exhibited linear or null relationships with age. Furthermore, the magnitude of age differences in MWF varied across the white matter tracts. Myelin content estimated by MWF was unrelated to FA and correlated with RD only in the splenium. These findings are consistent with the notion that myelination continues throughout the young adulthood into the middle age. The results demonstrate that single-tensor DTI cannot serve as a source of specific proxies for myelination of white matter tracts.
authors: Department of Psychiatry & Behavioral Neurosciences, School of Medicine, Wayne State University, Detroit, MI, United States; Institute of Gerontology, Wayne State University, Detroit, MI, United States.
authors: Muzamil
authors: M
authors: Arshad
authors: Department of Psychiatry & Behavioral Neurosciences, School of Medicine, Wayne State University, Detroit, MI, United States.
authors: Jeffrey A
authors: JA
authors: Stanley
authors: Institute of Gerontology, Wayne State University, Detroit, MI, United States; Department of Psychology, Wayne State University, Detroit, MI, United States. Electronic address: nraz@wayne.edu.
authors: Naftali
authors: N
authors: Raz
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D056324:Diffusion Tensor Imaging / Q000379:methods*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009186:Myelin Sheath / Q000378:metabolism*; D066127:White Matter / Q000000981:diagnostic imaging* / Q000378:metabolism*; D055815:Young Adult
keywords: Aging; Brain; Fractional Anisotropy; Multi-exponential T(2) relaxation; White Matter