title: Epigenetic mechanisms in microbial members of the human microbiota: current knowledge and perspectives.
abstract: The human microbiota and epigenetic processes have both been shown to play a crucial role in health and disease. However, there is extremely scarce information on epigenetic modulation of microbiota members except for a few pathogens. Mainly DNA adenine methylation has been described extensively in modulating the virulence of pathogenic bacteria in particular. It would thus appear likely that such mechanisms are widespread for most bacterial members of the microbiota. This review will present briefly the current knowledge on epigenetic processes in bacteria, give examples of known methylation processes in microbial members of the human microbiota and summarize the knowledge on regulation of host epigenetic processes by the human microbiota.
authors: Department of Food Science, University of Arkansas, Fayetteville, AR 72704, USA.
authors: Natacha
authors: N
authors: Cureau
authors: Cellular and Molecular Biology Program, University of Arkansas, Fayetteville, AR 72704, USA.
authors: Nesreen
authors: N
authors: AlJahdali
authors: Cellular and Molecular Biology Program, University of Arkansas, Fayetteville, AR 72704, USA.
authors: Nguyen
authors: N
authors: Vo
authors: Department of Food Science, University of Arkansas, Fayetteville, AR 72704, USA.|Cellular and Molecular Biology Program, University of Arkansas, Fayetteville, AR 72704, USA.
authors: Franck
authors: F
authors: Carbonero
mesh_terms: D019175:DNA Methylation; D004269:DNA, Bacterial / Q000235:genetics; D044127:Epigenesis, Genetic; D000069196:Gastrointestinal Microbiome / Q000235:genetics*; D006801:Humans
chemical_list: D004269:DNA, Bacterial
keywords: DNA methylation; epigenetics; human microbiota