title: Development of stained polymeric nanocapsules loaded with model drugs: Use of a fluorescent poly(phenyleneethynylene).
abstract: A phenyleneethynylene polymer (here denoted pPy3E-sqS) was synthesized and characterized by UV-vis spectroscopy, fluorescence spectroscopy, and TEM, and was used for the staining of polymeric nanocapsules. The nanocapsules presented good temporal stability, without changes in shape or fluorescence, and were suitable for use in drug release systems. The mean particle size was around 430nm, the polydispersity index was below 0.2, and the zeta potential was around -13mV. The release kinetics is one of the most important factors to consider in drug delivery systems, and here it was observed that nanocapsules containing the fluorescent polymer still maintained the ability to modulate the release of the fungicides tebuconazole and carbendazim (used as model drugs) after 4days. Preliminary results indicated that staining with the fluorescent pPy3E-sqS polymer could be used as a valuable tool to track the behavior of polymeric systems in the environment. However, further studies will be needed to clarify the environmental behavior and possible toxicity.
authors: Department of Environmental Engineering, State University of São Paulo, (UNESP), Sorocaba, SP, Brazil; Department of Biochemistry, Institute of Biology, State University of Campinas (UNICAMP), Cidade Universitária Zeferino Vaz, Campinas, SP, Brazil.
authors: Estefânia V R
authors: EVR
authors: Campos
authors: Department of Environmental Engineering, State University of São Paulo, (UNESP), Sorocaba, SP, Brazil.
authors: Jhones L
authors: JL
authors: Oliveira
authors: Centro de Investigácion en Quimica Aplicada (CIQA), Blvd Enrique Reyna 140, 25294, Saltillo, Coahuila, Mexico.
authors: Sara A
authors: SA
authors: Zavala-Betancourt
authors: Centro de Investigácion en Quimica Aplicada (CIQA), Blvd Enrique Reyna 140, 25294, Saltillo, Coahuila, Mexico.
authors: Antonio S
authors: AS
authors: Ledezma
authors: Centro de Investigácion en Quimica Aplicada (CIQA), Blvd Enrique Reyna 140, 25294, Saltillo, Coahuila, Mexico.
authors: Eduardo
authors: E
authors: Arias
authors: Centro de Investigácion en Quimica Aplicada (CIQA), Blvd Enrique Reyna 140, 25294, Saltillo, Coahuila, Mexico.
authors: Ivana
authors: I
authors: Moggio
authors: Centro de Investigácion en Quimica Aplicada (CIQA), Blvd Enrique Reyna 140, 25294, Saltillo, Coahuila, Mexico.
authors: Jorge
authors: J
authors: Romero
authors: Department of Environmental Engineering, State University of São Paulo, (UNESP), Sorocaba, SP, Brazil; Department of Biochemistry, Institute of Biology, State University of Campinas (UNICAMP), Cidade Universitária Zeferino Vaz, Campinas, SP, Brazil. Electronic address: leonardo@sorocaba.unesp.br.
authors: Leonardo F
authors: LF
authors: Fraceto
mesh_terms: D000480:Alkynes / Q000737:chemistry*; D001562:Benzimidazoles / Q000008:administration & dosage* / Q000737:chemistry; D002219:Carbamates / Q000008:administration & dosage* / Q000737:chemistry; D065546:Drug Liberation; D004355:Drug Stability; D004987:Ethers / Q000737:chemistry*; D005659:Fungicides, Industrial / Q000008:administration & dosage* / Q000737:chemistry; D008962:Models, Theoretical; D053769:Nanocapsules / Q000737:chemistry*; D010316:Particle Size; D011108:Polymers / Q000737:chemistry*; D014230:Triazoles / Q000008:administration & dosage* / Q000737:chemistry
chemical_list: D000480:Alkynes; D001562:Benzimidazoles; D002219:Carbamates; D004987:Ethers; D005659:Fungicides, Industrial; D053769:Nanocapsules; D011108:Polymers; D014230:Triazoles; C436384:phenyleneethynylene; C087114:tebuconazole; C006698:carbendazim
keywords: Environmental applications; Fluorescent polymer; Phenyleneethynylene polymer; Polymeric nanocapsules; Stained nanocapsules