title: Gene Editing: A New Tool for Viral Disease.
abstract: The emergence of the CRISPR/Cas system of antiviral adaptive immunity in bacteria as a facile system for gene editing in mammalian cells may well lead to gene editing becoming a novel treatment for a range of human diseases, especially those caused by deleterious germline mutations. Another potential target for gene editing are DNA viruses that cause chronic pathogenic diseases that cannot be cured by using currently available drugs. We review the current state of this field and discuss the potential advantages and problems with using a gene editing approach as a treatment for diseases caused by DNA viruses.
authors: Department of Molecular Genetics and Microbiology and Center for Virology, Duke University Medical Center, Durham, North Carolina 27710; email: edward.kennedy@duke.edu , bryan.cullen@duke.edu.
authors: Edward M
authors: EM
authors: Kennedy
authors: Department of Molecular Genetics and Microbiology and Center for Virology, Duke University Medical Center, Durham, North Carolina 27710; email: edward.kennedy@duke.edu , bryan.cullen@duke.edu.
authors: Bryan R
authors: BR
authors: Cullen
mesh_terms: D064113:CRISPR-Cas Systems; D004266:DNA Virus Infections / Q000628:therapy*; D004267:DNA Viruses / Q000235:genetics*; D000072669:Gene Editing; D015316:Genetic Therapy / Q000379:methods; D005822:Genetic Vectors; D015658:HIV Infections / Q000628:therapy*; D015497:HIV-1 / Q000235:genetics*; D006515:Hepatitis B virus / Q000235:genetics; D019694:Hepatitis B, Chronic / Q000628:therapy; D006558:Herpes Genitalis / Q000628:therapy; D006561:Herpes Simplex / Q000628:therapy; D018259:Herpesvirus 1, Human / Q000235:genetics; D018258:Herpesvirus 2, Human / Q000235:genetics; D006801:Humans; D027383:Papillomaviridae / Q000235:genetics; D030361:Papillomavirus Infections / Q000628:therapy
keywords: CRISPR/Cas; HIV-1; hepatitis B virus; herpes simplex virus; human papillomavirus