title: Gallstone disease is associated with arterial stiffness progression.
abstract: Gallstones have been linked to dyslipidemia, metabolic syndrome and cardiovascular disease. Arterial stiffness is an indicator of subclinical atherosclerosis. The aim of this study was to prospectively examine the relationship between gallstone disease and arterial stiffness progression in 347 men and 454 women. These subjects were followed for 7 years. Arterial stiffness progression was measured based on increases in brachial-ankle pulse wave velocity. Changes in brachial-ankle pulse wave velocity during the study period were significantly greater in patients with gallstones than in subjects without gallstones. After adjusting for multiple risk factors, gallstone disease was found to be a significant and independent predictor of brachial-ankle pulse wave velocity progression (β=0.189; P<0.001). In conclusion, gallstone disease is an independent predictor of arterial stiffness progression, even after adjusting for other cardiovascular risk factors.
authors: Department of Intensive Care Unit, the Third Affiliated Hospital, Harbin Medical University, Harbin, China.
authors: Kai-Jing
authors: KJ
authors: Yu
authors: Department of Geriatrics, the Second Affiliated Hospital, Harbin Medical University, Harbin, China.
authors: Ji-Rong
authors: JR
authors: Zhang
authors: Department of Geriatrics, the Second Affiliated Hospital, Harbin Medical University, Harbin, China.|International Physical Examination and Health Center, the Second Affiliated Hospital, Harbin Medical University, Harbin, China.
authors: Ying
authors: Y
authors: Li
authors: Biotherapy Center, the Third Affiliated Hospital, Harbin Medical University, Harbin, China.
authors: Xiaoyi
authors: X
authors: Huang
authors: Division of Hypothalamic Research, Department of Internal Medicine, UT Southwestern Medical Center, Dallas, TX, USA.
authors: Tiemin
authors: T
authors: Liu
authors: Department of Surgery and the Center of Excellence in Inflammation, Infectious Disease and Immunity, James H. Quillen College of Medicine, East Tennessee State University, Johnson City, TN, USA.
authors: Chuanfu
authors: C
authors: Li
authors: Department of Intensive Care Unit, the Third Affiliated Hospital, Harbin Medical University, Harbin, China.
authors: Rui-Tao
authors: RT
authors: Wang
mesh_terms: D000328:Adult; D055109:Ankle Brachial Index; D002318:Cardiovascular Diseases / Q000503:physiopathology*; D018450:Disease Progression; D005260:Female; D042882:Gallstones / Q000503:physiopathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D063177:Pulse Wave Analysis; D012307:Risk Factors; D059289:Vascular Stiffness / Q000502:physiology*