title: Notch signaling in cerebrovascular diseases (Review).
abstract: The Notch signaling pathway is a crucial regulator of numerous fundamental cellular processes. Increasing evidence suggests that Notch signaling is involved in inflammation and oxidative stress, and thus in the progress of cerebrovascular diseases. In addition, Notch signaling in cerebrovascular diseases is associated with apoptosis, angiogenesis and the function of blood‑brain barrier. Despite the contradictory results obtained to date as to whether Notch signaling is harmful or beneficial, the regulation of Notch signaling may provide a novel strategy for the treatment of cerebrovascular diseases.
authors: Department of Neurology, Renmin Hospital, Hubei University of Medicine, Shiyan, Hubei 442000, P.R. China.
authors: Zhiyou
authors: Z
authors: Cai
authors: Department of Neurology, Renmin Hospital, Hubei University of Medicine, Shiyan, Hubei 442000, P.R. China.
authors: Bin
authors: B
authors: Zhao
authors: Department of Neurology, Renmin Hospital, Hubei University of Medicine, Shiyan, Hubei 442000, P.R. China.
authors: Yanqing
authors: Y
authors: Deng
authors: Department of Neurology, Renmin Hospital, Hubei University of Medicine, Shiyan, Hubei 442000, P.R. China.
authors: Shouqin
authors: S
authors: Shangguan
authors: Department of Neurology, Renmin Hospital, Hubei University of Medicine, Shiyan, Hubei 442000, P.R. China.
authors: Faming
authors: F
authors: Zhou
authors: Department of Neurology, Renmin Hospital, Hubei University of Medicine, Shiyan, Hubei 442000, P.R. China.
authors: Wenqing
authors: W
authors: Zhou
authors: Department of Neurology, Renmin Hospital, Hubei University of Medicine, Shiyan, Hubei 442000, P.R. China.
authors: Xiaoli
authors: X
authors: Li
authors: Department of Neurology, Peking Union Medical College Hospital, Beijing 100730, P.R. China.
authors: Yanfeng
authors: Y
authors: Li
authors: Department of Neurology, Renmin Hospital, Hubei University of Medicine, Shiyan, Hubei 442000, P.R. China.
authors: Guanghui
authors: G
authors: Chen
mesh_terms: D000818:Animals; D017209:Apoptosis; D001812:Blood-Brain Barrier / Q000276:immunology / Q000378:metabolism / Q000473:pathology; D002561:Cerebrovascular Disorders / Q000150:complications / Q000276:immunology / Q000378:metabolism* / Q000473:pathology*; D006801:Humans; D007249:Inflammation / Q000150:complications / Q000276:immunology / Q000378:metabolism / Q000473:pathology; D009389:Neovascularization, Pathologic / Q000150:complications / Q000276:immunology / Q000378:metabolism / Q000473:pathology; D018384:Oxidative Stress; D051880:Receptors, Notch / Q000276:immunology / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D051880:Receptors, Notch