title: Lysyl oxidase isoforms in gastric cancer.
abstract: Gastric cancer (GC) is the fifth most frequent cancer in the world and shows the highest incidence in Latin America and Asia. An increasing amount of evidence demonstrates that lysyl oxidase isoforms, a group of extracellular matrix crosslinking enzymes, should be considered as potential biomarkers and therapeutic targets in GC. In this review, we focus on the expression levels of lysyl oxidase isoforms, its functions and the clinical implications in GC. Finding novel proteins related to the processing of these extracellular matrix enzymes might be helpful in the design of new therapies, which, in combination with classic pharmacology, could be used to delay the progress of this aggressive cancer and offer a wider temporal window for clinical intervention.
authors: Biomedical Research Labs, Medicine Faculty, Catholic University of Maule, Talca, Chile.
authors: Carolina
authors: C
authors: Añazco
authors: Biomedical Research Labs, Medicine Faculty, Catholic University of Maule, Talca, Chile.
authors: Fernando
authors: F
authors: Delgado-López
authors: Biomedical Research Labs, Medicine Faculty, Catholic University of Maule, Talca, Chile.
authors: Paulina
authors: P
authors: Araya
authors: Biomedical Research Labs, Medicine Faculty, Catholic University of Maule, Talca, Chile.
authors: Ileana
authors: I
authors: González
authors: Biomedical Research Labs, Medicine Faculty, Catholic University of Maule, Talca, Chile.|Pathology Department, Regional Hospital of Talca, Talca, Chile.
authors: Erik
authors: E
authors: Morales
authors: Biomedical Research Labs, Medicine Faculty, Catholic University of Maule, Talca, Chile.
authors: Ramón
authors: R
authors: Pérez-Castro
authors: Biomedical Research Labs, Medicine Faculty, Catholic University of Maule, Talca, Chile.
authors: Jacqueline
authors: J
authors: Romero
authors: Biomedical Research Labs, Medicine Faculty, Catholic University of Maule, Talca, Chile.
authors: Armando
authors: A
authors: Rojas
mesh_terms: D014408:Biomarkers, Tumor / Q000378:metabolism; D002614:Chelating Agents / Q000627:therapeutic use; D003094:Collagen / Q000378:metabolism; D004549:Elastin / Q000378:metabolism; D005355:Fibrosis; D006801:Humans; D009362:Neoplasm Metastasis; D020033:Protein Isoforms / Q000378:metabolism; D008249:Protein-Lysine 6-Oxidase / Q000378:metabolism*; D013274:Stomach Neoplasms / Q000188:drug therapy / Q000378:metabolism / Q000473:pathology*
chemical_list: D014408:Biomarkers, Tumor; D002614:Chelating Agents; D020033:Protein Isoforms; D003094:Collagen; D004549:Elastin; D008249:Protein-Lysine 6-Oxidase
keywords: Helicobacter pylori; basement membrane; collagen; copper depletion; extracellular matrix; fibrosis; gastric cancer; lysyl oxidase isoforms; tumor promoter; tumor suppressor