title: Silkworm pupae oil exerts hypercholesterolemic and antioxidant effects in high-cholesterol diet-fed rats.
abstract: BACKGROUND
  Silkworm pupae is a good resource of edible oil that is especially rich in unsaturated fatty acids and is considered to be an excellent dietary supplement for hyperlipidemia.
  
  
  RESULTS
  Groups fed a high-cholesterol diet (HCD) with silkworm pupae oil (SPO) supplementation (1, 2, or 4 mL kg-1day-1) orally had significantly lower levels of serum total cholesterol (P < 0.05) and low-density lipoprotein cholesterol (P < 0.05) compared to the HCD group. With regard to antioxidant parameters, except for levels of glutathione peroxidase (GSH-Px) in the liver, 2 and 4 mL kg-1day-1of SPO supplementation leaded to higher total antioxidant capacity (P < 0.05), superoxide dismutase (P < 0.05) and GSH-Px levels (P < 0.05), as well as lower malondialdehyde levels (P < 0.05), both in serum and liver compared to the HCD group.
  
  
  CONCLUSIONS
  The results of the present study indicate that supplementation with SPO can improve lipid profiles and alleviate oxidative stress in high-cholesterol diet-fed rats. © 2016 Society of Chemical Industry.
authors: Sericultural & Agri-Food Research Institute, Guangdong Academy of Agricultural Sciences, Guangzhou, China.|Key Laboratory of Functional Foods, Ministry of Agriculture, Guangzhou, China.|Guangdong Key Laboratory of Agricultural Products Processing, Guangzhou, China.
authors: Yuxiao
authors: Y
authors: Zou
authors: Sericultural & Agri-Food Research Institute, Guangdong Academy of Agricultural Sciences, Guangzhou, China.|Key Laboratory of Functional Foods, Ministry of Agriculture, Guangzhou, China.|Guangdong Key Laboratory of Agricultural Products Processing, Guangzhou, China.
authors: Tenggen
authors: T
authors: Hu
authors: Sericultural & Agri-Food Research Institute, Guangdong Academy of Agricultural Sciences, Guangzhou, China.|Key Laboratory of Functional Foods, Ministry of Agriculture, Guangzhou, China.|Guangdong Key Laboratory of Agricultural Products Processing, Guangzhou, China.
authors: Ying
authors: Y
authors: Shi
authors: Sericultural & Agri-Food Research Institute, Guangdong Academy of Agricultural Sciences, Guangzhou, China.|Key Laboratory of Functional Foods, Ministry of Agriculture, Guangzhou, China.|Guangdong Key Laboratory of Agricultural Products Processing, Guangzhou, China.
authors: Sentai
authors: S
authors: Liao
authors: Sericultural & Agri-Food Research Institute, Guangdong Academy of Agricultural Sciences, Guangzhou, China.|Key Laboratory of Functional Foods, Ministry of Agriculture, Guangzhou, China.|Guangdong Key Laboratory of Agricultural Products Processing, Guangzhou, China.
authors: Jun
authors: J
authors: Liu
authors: Sericultural & Agri-Food Research Institute, Guangdong Academy of Agricultural Sciences, Guangzhou, China.|Key Laboratory of Functional Foods, Ministry of Agriculture, Guangzhou, China.|Guangdong Key Laboratory of Agricultural Products Processing, Guangzhou, China.
authors: Lixia
authors: L
authors: Mu
authors: Antioxidants Research Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA, USA.
authors: C-Y Oliver
authors: CO
authors: Chen
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage* / Q000302:isolation & purification; D001685:Biological Factors / Q000008:administration & dosage* / Q000302:isolation & purification; D012831:Bombyx / Q000737:chemistry* / Q000254:growth & development; D002791:Cholesterol, Dietary / Q000009:adverse effects / Q000378:metabolism*; D008078:Cholesterol, LDL / Q000378:metabolism; D019587:Dietary Supplements / Q000032:analysis; D005979:Glutathione Peroxidase / Q000378:metabolism; D006801:Humans; D006937:Hypercholesterolemia / Q000188:drug therapy* / Q000201:enzymology / Q000209:etiology / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D018384:Oxidative Stress / Q000187:drug effects; D011679:Pupa / Q000737:chemistry* / Q000254:growth & development; D051381:Rats; D017208:Rats, Wistar
chemical_list: D000975:Antioxidants; D001685:Biological Factors; D002791:Cholesterol, Dietary; D008078:Cholesterol, LDL; D008315:Malondialdehyde; D005979:Glutathione Peroxidase
keywords: antioxidant effects; high-cholesterol diet; high-cholesterol diet-fed rats; hypercholesterolemic effect; silkworm pupae oil