title: Liver fibrosis assessment by FibroScan compared with pathological findings of liver resection specimen in hepatitis C infection.
abstract: OBJECTIVE
  FibroScan is a tool for the non-invasive diagnosis of hepatic fibrosis. Previous studies have compared liver stiffness to percutaneous liver biopsy findings, but no study has compared liver stiffness to liver resection specimen findings. The aim of this study was to compare FibroScan measurements to resected liver specimen findings.
  
  
  METHODS
  From April 2011 to November 2015, a total of 114 patients with liver tumor and hepatitis C were enrolled. We divided them into two groups, the training set and validation set. Liver stiffness was measured by FibroScan before surgery, and specimens obtained by liver resection were evaluated according to the METAVIR system.
  
  
  RESULTS
  Using Spearman's rank correlation analysis, a positive correlation between liver stiffness measurement and liver fibrosis stage was observed (r = 0.786, P ≤ 0.0001). In the training set, the area under receiver operating curves for diagnosis of F ≥ 2 was 0.971 (95% confidence interval, 0.928-1.000; cut-off value, 5.9), for diagnosis of F ≥ 3 was 0.911 (0.825-0.997, 9.8), and for diagnosis of F = 4 was 0.917 (0.849-0.985, 15.5). In the validation set, at a cut-off value of 5.9 kPa, sensitivity, specificity, positive predictive values, and negative predictive values for F ≥ 2 were 95.7%, 0.0%, 97.8%, and 0.0%, respectively, of 9.8 kPa for F ≥ 3 were 86.2%, 52.6%, 73.5%, and 71.4%, and of 15.5 kPa for F = 4 were 100%, 71.8%, 45.0%, and 100%.
  
  
  CONCLUSIONS
  The stage of stiffness graded by FibroScan has a good correlation with the liver fibrosis of resected liver specimens. It has the ability to diagnose fibrosis stage non-invasively.
authors: Department of Gastroenterology and Metabolism, Hiroshima University Hospital, Hiroshima, Japan.
authors: Yuki
authors: Y
authors: Nakamura
authors: Department of Gastroenterology and Metabolism, Hiroshima University Hospital, Hiroshima, Japan.
authors: Hiroshi
authors: H
authors: Aikata
authors: Department of Gastroenterology and Metabolism, Hiroshima University Hospital, Hiroshima, Japan.
authors: Takayuki
authors: T
authors: Fukuhara
authors: Department of Gastroenterology and Metabolism, Hiroshima University Hospital, Hiroshima, Japan.
authors: Fumi
authors: F
authors: Honda
authors: Department of Gastroenterology and Metabolism, Hiroshima University Hospital, Hiroshima, Japan.
authors: Kei
authors: K
authors: Morio
authors: Department of Gastroenterology and Metabolism, Hiroshima University Hospital, Hiroshima, Japan.
authors: Reona
authors: R
authors: Morio
authors: Department of Gastroenterology and Metabolism, Hiroshima University Hospital, Hiroshima, Japan.
authors: Masahiro
authors: M
authors: Hatooka
authors: Department of Gastroenterology and Metabolism, Hiroshima University Hospital, Hiroshima, Japan.
authors: Tomoki
authors: T
authors: Kobayashi
authors: Department of Gastroenterology and Metabolism, Hiroshima University Hospital, Hiroshima, Japan.
authors: Yuko
authors: Y
authors: Nagaoki
authors: Department of Gastroenterology and Metabolism, Hiroshima University Hospital, Hiroshima, Japan.
authors: Tomokazu
authors: T
authors: Kawaoka
authors: Department of Gastroenterology and Metabolism, Hiroshima University Hospital, Hiroshima, Japan.
authors: Masataka
authors: M
authors: Tsuge
authors: Department of Gastroenterology and Metabolism, Hiroshima University Hospital, Hiroshima, Japan.
authors: Akira
authors: A
authors: Hiramatsu
authors: Department of Gastroenterology and Metabolism, Hiroshima University Hospital, Hiroshima, Japan.
authors: Michio
authors: M
authors: Imamura
authors: Department of Gastroenterology and Metabolism, Hiroshima University Hospital, Hiroshima, Japan.
authors: Yoshiiku
authors: Y
authors: Kawakami
authors: Department of Gastroenterology and Metabolism, Hiroshima University Hospital, Hiroshima, Japan.
authors: Hidenori
authors: H
authors: Ochi
authors: Department of Gastroenterological and Transplant Surgery, Hiroshima University Hospital, Hiroshima, Japan.
authors: Tsuyoshi
authors: T
authors: Kobayashi
authors: Department of Gastroenterological and Transplant Surgery, Hiroshima University Hospital, Hiroshima, Japan.
authors: Hideki
authors: H
authors: Ohdan
authors: Department of Anatomical Pathology, Hiroshima University Hospital, Hiroshima, Japan.
authors: Noriyuki
authors: N
authors: Shiroma
authors: Department of Anatomical Pathology, Hiroshima University Hospital, Hiroshima, Japan.
authors: Koji
authors: K
authors: Arihiro
authors: Department of Gastroenterology and Metabolism, Hiroshima University Hospital, Hiroshima, Japan.
authors: Kazuaki
authors: K
authors: Chayama
keywords: FibroScan; liver stiffness; non-invasive diagnosis