title: Risk of Hodgkin lymphoma according to immigration status and origin: a migrant cohort study of 2.3 million Jewish Israelis.
abstract: Hodgkin Lymphoma (HL), a common early adulthood malignancy, has a complex etiology. We conducted a migrant cohort study to assess immigration status and origin as predictors of HL in Israel, which has among the highest rates of HL worldwide. Nationwide data on 2,285,009 16-19-year-old Jewish adolescents, collected from 1967-2011, were linked to Israel's Cancer Registry to obtain the incidence of HL until 2012. Two thousand and ninety-three HL cases were detected during 47.0 million person-years of follow-up. Using multivariable-adjusted Cox proportional hazards modeling, risk was higher for Israeli-born compared to immigrants, similarly across origin groups (HR = 1.59; 95%CI 1.32-1.92 for the dominant nodular sclerosis subtype). Risk of HL was greater for more recent year of birth, higher BMI, taller stature, and apparently for women. These findings suggest that exposure to as yet unidentified elements of the Israeli environment increase the risk of nodular sclerosis HL, and should aid in directing research efforts.
authors: a Hebrew University-Hadassah Braun School of Public Health and Community Medicine , Jerusalem , Israel.|b Department of Preventive Medicine , Icahn School of Medicine at Mount Sinai , New York , NY , USA.
authors: Hagai
authors: H
authors: Levine
authors: c Multiple Myeloma Service, Division of Hematology , Sheba Medical Center , Tel Hashomer , Ramat-Gan , Israel.|d Sackler Faculty of Medicine , Tel Aviv University , Tel-Aviv , Israel.
authors: Merav
authors: M
authors: Leiba
authors: d Sackler Faculty of Medicine , Tel Aviv University , Tel-Aviv , Israel.
authors: Yael
authors: Y
authors: Bar Zeev
authors: e The National Cancer Registry, Israel Center for Disease Control, Ministry of Health , Jerusalem , Israel.|f School of Public Health, University of Haifa , Haifa , Israel.
authors: Lital
authors: L
authors: Keinan-Boker
authors: d Sackler Faculty of Medicine , Tel Aviv University , Tel-Aviv , Israel.|g The Israel Defense Forces Medical Corps , Jerusalem , Israel.
authors: Estela
authors: E
authors: Derazne
authors: d Sackler Faculty of Medicine , Tel Aviv University , Tel-Aviv , Israel.|g The Israel Defense Forces Medical Corps , Jerusalem , Israel.|h Department of Medicine and Medical Education , Mount Auburn Hospital, Harvard Medical School , Boston , MA , USA.
authors: Adi
authors: A
authors: Leiba
authors: a Hebrew University-Hadassah Braun School of Public Health and Community Medicine , Jerusalem , Israel.
authors: Jeremy D
authors: JD
authors: Kark
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D054242:Emigrants and Immigrants; D004641:Emigration and Immigration; D005260:Female; D006689:Hodgkin Disease / Q000453:epidemiology*; D006801:Humans; D015994:Incidence; D007557:Israel / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D011159:Population Surveillance; D012042:Registries; D012307:Risk Factors; D012737:Sex Factors; D012959:Socioeconomic Factors; D055815:Young Adult
keywords: Hodgkin lymphoma; environment; life course epidemiology; migration; stress; young adults