title: Effects of self-reported calorie restriction on correlations between SIRT1 polymorphisms and body mass index and long-term weight change.
abstract: SIRT1 acts as a cellular sensor to detect energy availability and modulates fat and glucose metabolism. This study assessed the effects of self-reported calorie restriction (CR) and exercise on correlations between SIRT1 polymorphisms and body mass index (BMI) and long-term weight change. This cross-sectional study enrolled 4023 subjects aged 35-69years (1847 men and 2176 women) selected from participants in the Japan Multi-Institutional Collaborative Cohort Study. This study was based on a self-administered questionnaire. No significant correlations between SIRT1 polymorphisms and BMI or long-term weight change were found in either the CR or the active groups. In the no-CR group, women with the rs1467568 G allele had a higher BMI than women without (p=0.02). Moreover, women with the rs7895833 A or rs1467568 G allele gained more weight from the age of 20years than women without these alleles (p=0.03 for rs7895833 and p=0.003 for rs1467568). In addition, the odds ratios (95% confidence intervals) of these alleles for overweight (BMI >27.5kg/m2) were significantly high in the no-CR women group (1.78 (1.06-2.99) for rs7895833 and 1.88 (1.13-3.15) for rs1467568) but not in the CR group. The results of this study suggest that CR might override the genetic contributions of the SIRT1 rs7895833 A and rs1467568 G alleles to BMI and long-term weight change.
authors: Department of Preventive Medicine, Nagoya University Graduate School of Medicine, Nagoya, Japan. Electronic address: hgsbata@gmail.com.
authors: Takahiro
authors: T
authors: Higashibata
authors: Department of Preventive Medicine, Nagoya University Graduate School of Medicine, Nagoya, Japan.
authors: Kenji
authors: K
authors: Wakai
authors: Department of Preventive Medicine, Nagoya University Graduate School of Medicine, Nagoya, Japan.
authors: Mariko
authors: M
authors: Naito
authors: Department of Preventive Medicine, Nagoya University Graduate School of Medicine, Nagoya, Japan.
authors: Emi
authors: E
authors: Morita
authors: Department of Preventive Medicine, Nagoya University Graduate School of Medicine, Nagoya, Japan.
authors: Asahi
authors: A
authors: Hishida
authors: Department of Healthcare Administration, Nagoya University Graduate School of Medicine, Nagoya, Japan.
authors: Nobuyuki
authors: N
authors: Hamajima
authors: Department of Preventive Medicine, Faculty of Medicine, Saga University, Saga, Japan.
authors: Megumi
authors: M
authors: Hara
authors: Department of Public Health, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.
authors: Sadao
authors: S
authors: Suzuki
authors: Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan.
authors: Satoyo
authors: S
authors: Hosono
authors: Department of Health Science, Shiga University of Medical Science, Otsu, Japan.
authors: Naoyuki
authors: N
authors: Takashima
authors: Department of Geriatric Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
authors: Keizo
authors: K
authors: Ohnaka
authors: Shinagawa Cosmetic Surgery, Tokyo, Japan.
authors: Akihiko
authors: A
authors: Takada
authors: Division of Cancer Registry, Prevention and Epidemiology, Chiba Cancer Center, Chiba, Japan.
authors: Haruo
authors: H
authors: Mikami
authors: Department of Epidemiology for Community Health and Medicine, Kyoto Prefectural University of Medicine, Kyoto, Japan.
authors: Yoshiyuki
authors: Y
authors: Watanabe
authors: Department of Preventive Medicine, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima, Japan.
authors: Hirokazu
authors: H
authors: Uemura
authors: Center for Integrative Medical Sciences, RIKEN, Yokohama, Japan.
authors: Michiaki
authors: M
authors: Kubo
authors: Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan.
authors: Hideo
authors: H
authors: Tanaka
mesh_terms: D000328:Adult; D000483:Alleles; D015992:Body Mass Index; D031204:Caloric Restriction; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008297:Male; D050177:Overweight / Q000235:genetics* / Q000473:pathology / Q000628:therapy; D011110:Polymorphism, Genetic; D057566:Self Report; D056564:Sirtuin 1 / Q000235:genetics*; D013997:Time Factors
chemical_list: C447939:SIRT1 protein, human; D056564:Sirtuin 1
keywords: Cross-sectional study; Gene-environment interaction; Overweight; SIRT1