title: Mechanically tuned nanocomposite coating on titanium metal with integrated properties of biofilm inhibition, cell proliferation, and sustained drug delivery.
abstract: The clinical success of coated implants in executing biological functions inclusive of sustainable drug release and long term antibacterial activity without antibiotics is critical. To this aim, a nanohybrid of silver nanoparticles (AgNPs) cored in polyvinyl alcohol nanocapsules (Ag-PVA NCs) embedded in chitosan (CS) matrix loaded with anti-inflammatory drug naproxen was prepared. The synthesized nanohybrids that were subjected to coatings on (3-aminopropyl)triethoxysilane (APTES) treated titanium (Ti) metal exhibited dual role of excellent inhibition on biofilm formation and sustained drug release. These dual characteristics are achieved mainly based on intrinsic antibacterial property of AgNPs and differential entrapment of drug in PVA polymeric shell of AgNPs and CS matrix. The coatings also demonstrated enhanced mechanical properties with increasing inorganic filler and stress shielding on Ti metal. The biocompatibility tests involving adhesion, proliferation and differentiation of osteoblast cells demonstrated the efficacy of Ag-PVA NCs embedded in CS matrix as a suitable coating material for orthopedic applications.
authors: Centre for Nanoscience and Technology, Pondicherry University, Puducherry, India.
authors: Sandeep K
authors: SK
authors: Mishra
authors: Department of Biological Sciences & Bioengineering, Center for Environmental Sciences and Engineering, Indian Institute of Technology Kanpur, Kanpur, UP, India.
authors: Arun K
authors: AK
authors: Teotia
authors: Department of Biological Sciences & Bioengineering, Center for Environmental Sciences and Engineering, Indian Institute of Technology Kanpur, Kanpur, UP, India.
authors: Ashok
authors: A
authors: Kumar
authors: Centre for Nanoscience and Technology, Pondicherry University, Puducherry, India. Electronic address: para_kanna@yahoo.com.
authors: Sanjeevi
authors: S
authors: Kannan
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology; D018441:Biofilms / Q000187:drug effects*; D002460:Cell Line; D049109:Cell Proliferation; D020099:Coated Materials, Biocompatible / Q000494:pharmacology*; D016503:Drug Delivery Systems; D065546:Drug Liberation; D006801:Humans; D053768:Metal Nanoparticles / Q000737:chemistry; D008826:Microbial Sensitivity Tests; D053761:Nanocomposites / Q000737:chemistry*; D009288:Naproxen / Q000494:pharmacology; D010006:Osteoblasts / Q000166:cytology / Q000187:drug effects; D012834:Silver / Q000494:pharmacology*; D014025:Titanium / Q000737:chemistry*
chemical_list: D000900:Anti-Bacterial Agents; D020099:Coated Materials, Biocompatible; D012834:Silver; D009288:Naproxen; D014025:Titanium
keywords: Chitosan; Microwave synthesis; Nanohybrid; Nanoindentation; Naproxen; Silver nanoparticles