title: Selective Serotonin-norepinephrine Reuptake Inhibitors-induced Takotsubo Cardiomyopathy.
abstract: BACKGROUND
  Takotsubo translates to "octopus pot" in Japanese. Takotsubo cardiomyopathy (TTC) is characterized by a transient regional systolic dysfunction of the left ventricle. Catecholamine excess is the one most studied and favored theories explaining the pathophysiology of TTC.
  
  
  METHODS
  We present the case of a 52-year-old Hispanic female admitted for venlafaxine-induced TTC with a review literature on all the cases of Serotonin-norepinephrine reuptake inhibitors (SNRI)-associated TTC published so far.
  
  
  CONCLUSIONS
  SNRI inhibit the reuptake of catecholamines into the presynaptic neuron, resulting in a net gain in the concentration of epinephrine and serotonin in the neuronal synapses and causing iatrogenic catecholamine excess, ultimately leading to TTC.
authors: Department of Internal Medicine, New York Medical College, St Joseph's Regional Medical Center, New Jersey, USA.
authors: Rahul
authors: R
authors: Vasudev
authors: Department of Cardiology, New York Medical College, St Joseph's Regional Medical Center, New Jersey, USA.
authors: Upamanyu
authors: U
authors: Rampal
authors: Department of Cardiology, New York Medical College, St Joseph's Regional Medical Center, New Jersey, USA.
authors: Hiten
authors: H
authors: Patel
authors: Department of Cardiology, New York Medical College, St Joseph's Regional Medical Center, New Jersey, USA.
authors: Kunal
authors: K
authors: Patel
authors: Department of Cardiology, New York Medical College, St Joseph's Regional Medical Center, New Jersey, USA.
authors: Mahesh
authors: M
authors: Bikkina
authors: Department of Cardiology, New York Medical College, St Joseph's Regional Medical Center, New Jersey, USA.
authors: Fayez
authors: F
authors: Shamoon
keywords: Apical ballooning syndrome; Takotsubo cardiomyopathy; selective serotonin-norepinephrine reuptake inhibitors; stress-induced cardiomyopathy