title: Biological Analysis of Human CML Stem Cells; Xenograft Model of Chronic Phase Human Chronic Myeloid Leukemia.
abstract: Xenograft mouse models have been instrumental in expanding our knowledge of hematopoiesis and can provide a functional description of stem cells that possess engrafting potential. Here we describe methodology outlining one way of analyzing human malignant cells that are able to engraft immune compromised mice. Using models such as these will allow researchers to gain valuable insight into the primitive leukemic subtypes that evade current therapy regimes and are critical to understand, in order to eradicate malignancy.
authors: Paul O'Gorman Leukaemia Research Centre, College of Medical, Veterinary & Life Sciences, Institute of Cancer Sciences, University of Glasgow, 21 Shelley Rd, Gartnavel General Hospital, Glasgow, G12 OZD, UK. Sheela.Abraham@glasgow.ac.uk.
authors: Sheela A
authors: SA
authors: Abraham
mesh_terms: D000818:Animals; D005260:Female; D016044:Fusion Proteins, bcr-abl; D006801:Humans; D016867:Immunocompromised Host; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000473:pathology*; D051379:Mice; D016513:Mice, SCID; D009368:Neoplasm Transplantation; D014411:Neoplastic Stem Cells / Q000473:pathology*; D014183:Transplantation, Heterologous
chemical_list: D016044:Fusion Proteins, bcr-abl
keywords: Chronic myeloid leukemia; Engraftment; Immune compromised; Mouse; NSG; Xenograft