title: Beyond Cohort Selection: An Analytics-Enabled i2b2.
abstract: The i2b2 software is a widely adopted solution for secondary use of clinical data for clinical research, specifically designed for cohort identification. i2b2 is still lacking functionalities for data analysis. The aim of this work is to empower the i2b2 framework enabling clinical researchers to perform statistical analyses for accelerating the process of hypothesis testing. To this aim we have developed a flexible extension of i2b2 able to exploit different statistical engines. We have implemented some first applications for basic statistics and survival analyses, exploiting this extension and accessible through suitable user interfaces designed with a special consideration for usability.
authors: BIOMERIS s.r.l., Pavia, Italy.
authors: Matteo
authors: M
authors: Gabetta
authors: Fondazione IRCCS S. Maugeri, Pavia, Italy.
authors: Alberto
authors: A
authors: Malovini
authors: BIOMERIS s.r.l., Pavia, Italy.
authors: Mauro
authors: M
authors: Bucalo
authors: Center for Health Technologies, Università di Pavia, Pavia, Italy.
authors: Elisa
authors: E
authors: Zini
authors: Fondazione IRCCS S. Maugeri, Pavia, Italy.
authors: Valentina
authors: V
authors: Tibollo
authors: Fondazione IRCCS S. Maugeri, Pavia, Italy.
authors: Silvia G
authors: SG
authors: Priori
authors: Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
authors: Simone
authors: S
authors: Vettoretti
authors: Center for Health Technologies, Università di Pavia, Pavia, Italy.
authors: Cristiana
authors: C
authors: Larizza
authors: Center for Health Technologies, Università di Pavia, Pavia, Italy.
authors: Riccardo
authors: R
authors: Bellazzi
authors: BIOMERIS s.r.l., Pavia, Italy.
authors: Nicola
authors: N
authors: Barbarini
mesh_terms: D015331:Cohort Studies; D016208:Databases, Factual; D066275:Health Information Exchange; D006801:Humans; D016247:Information Storage and Retrieval / Q000379:methods; D057386:Search Engine; D012984:Software; D014584:User-Computer Interface