title: Posttransplant Urinary Tract Infection Rates and Graft Outcome in Kidney Transplantation for End-Stage Renal Disease Due to Reflux Nephropathy Versus Chronic Glomerulonephritis.
abstract: BACKGROUND
  The goal of this study was to evaluate posttransplant urinary tract infection (UTI) rates and graft outcome in kidney transplantation for end-stage renal disease (ESRD) due to vesicoureteral reflux (VUR)-related reflux nephropathy (RN) versus chronic glomerulonephritis (CGN).
  
  
  METHODS
  A total of 62 patients with ESRD who underwent kidney transplantation for VUR-related RN (VUR-RN group, n = 31; mean ± standard deviation age, 34.1 ± 6.0 years; 58.1% female) or CGN (CGN group, n = 31; mean age, 34.2 ± 6.8 years; 71.0% male) at our unit between January 1996 and January 2011 were included in this retrospective study. Baseline recipient and donor characteristics, renal replacement therapy, posttransplant data on serum creatinine levels, graft outcome, and UTIs were recorded. Posttransplant UTIs and graft outcome were compared between the VUR-RN and CGN groups, as well as between patients with and without pretransplant nephrectomy in the VUR-RN group.
  
  
  RESULTS
  The frequency of overall (72 vs 18 of 90; P = .05) UTI episodes was significantly higher in the VUR-RN group than in the CGN group; Escherichia coli (64.2%) was the most common pathogen. The VUR-RN and CGN groups were similar in terms of 1-year (100.0% for each), 5-year (95.8% vs 96.8%), and 10-year (82.0% vs 96.8%) graft survival. VUR-RN patients with and without nephrectomy were similar in terms of 1-year (100.0% for each), 5-year (91.7% vs 85.7%), and 10-year (81.5% vs 85.7%) graft survival.
  
  
  CONCLUSIONS
  Our findings indicate kidney transplantation is a safe and effective option in ESRD patients with RN secondary to VUR. It resulted in high 1-year, 5-year, and 10-year graft survival rates.
authors: Recep Tayyip Erdogan University, Faculty of Medicine, Department of Internal Medicine, Rize, Turkey. Electronic address: karaekrem79@hotmail.com.
authors: E
authors: E
authors: Kara
authors: Sisli Etfal Educational and Research Hospital, Department of Nephrology, Istanbul, Turkey.
authors: T
authors: T
authors: Sakaci
authors: Sisli Etfal Educational and Research Hospital, Department of Nephrology, Istanbul, Turkey.
authors: E
authors: E
authors: Ahbap
authors: Sisli Etfal Educational and Research Hospital, Department of Nephrology, Istanbul, Turkey.
authors: T
authors: T
authors: Sahutoglu
authors: Sisli Etfal Educational and Research Hospital, Department of Nephrology, Istanbul, Turkey.
authors: Y
authors: Y
authors: Koc
authors: Sisli Etfal Educational and Research Hospital, Department of Nephrology, Istanbul, Turkey.
authors: T
authors: T
authors: Basturk
authors: Sisli Etfal Educational and Research Hospital, Department of Nephrology, Istanbul, Turkey.
authors: M
authors: M
authors: Sevinc
authors: Sisli Etfal Educational and Research Hospital, Department of Nephrology, Istanbul, Turkey.
authors: C
authors: C
authors: Akgol
authors: Sisli Etfal Educational and Research Hospital, Department of Nephrology, Istanbul, Turkey.
authors: A O
authors: AO
authors: Kayalar
authors: Sisli Etfal Educational and Research Hospital, Department of Nephrology, Istanbul, Turkey.
authors: Z A
authors: ZA
authors: Ucar
authors: Sisli Etfal Educational and Research Hospital, Department of Nephrology, Istanbul, Turkey.
authors: A
authors: A
authors: Unsal
authors: Istanbul University, Cerrahpasa Medical Faculty, Department of Internal Medicine, Division of Nephrology, Istanbul, Turkey.
authors: N
authors: N
authors: Seyahi
mesh_terms: D000328:Adult; D002908:Chronic Disease; D005260:Female; D005921:Glomerulonephritis / Q000150:complications; D006085:Graft Survival; D006801:Humans; D007674:Kidney Diseases / Q000150:complications; D007676:Kidney Failure, Chronic / Q000601:surgery*; D016030:Kidney Transplantation / Q000009:adverse effects*; D008297:Male; D009392:Nephrectomy / Q000009:adverse effects; D011183:Postoperative Complications / Q000209:etiology; D011704:Pyelonephritis / Q000150:complications; D012189:Retrospective Studies; D014019:Tissue Donors; D014552:Urinary Tract Infections / Q000209:etiology*; D014718:Vesico-Ureteral Reflux / Q000150:complications