title: Human Uterine Cervical Stromal Stem Cells (hUCESCs): Why and How they Exert their Antitumor Activity.
abstract: Our research team has recently isolated and characterized a new stromal stem cell line (hUCESCs) obtained from cytological smears, as routinely performed for cervical cancer screening. We have, furthermore, described that both hUCESCs directly, as well as the secretome contained in the conditioned medium used for growing them (hUCESCs-CM) have potent antitumoral, anti-inflammatory, antibiotic, antimycotic and re-epitheliasation-enhancing properties. The scientific explanation our team proposes for these pleiotropic effects are directly related to the site of origin of hUCESCs, the human cervical transition zone, which has unique features that biologically justify the different actions of hUCESCs and hUCESCs-CM. We, herein, expose our working theory for the biological activity of hUCESCs and hUCESCs-CM.
authors: Universidad de Valladolid, Facultad de Medicina, Valladolid, Spain Fundación Para la Investigación de Células Madre Uterinas (FICEMU), Gijón, Spain jose.schneider@uva.es.
authors: José
authors: J
authors: Schneider
authors: Fundación Para la Investigación de Células Madre Uterinas (FICEMU), Gijón, Spain Hospital de Jove, Gijón, Spain.
authors: Noemí
authors: N
authors: Eiró
authors: Universidad de Santiago de Compostela, Departamento de Fisiología, Centro de Investigaciones Médicas (CIMUS), Santiago de Compostela, Spain.
authors: Román
authors: R
authors: Pérez-Fernández
authors: Universidad de Santiago de Compostela, Departamento de Fisiología, Centro de Investigaciones Médicas (CIMUS), Santiago de Compostela, Spain.
authors: Anxo
authors: A
authors: Martínez-Ordóñez
authors: Fundación Para la Investigación de Células Madre Uterinas (FICEMU), Gijón, Spain Hospital de Jove, Gijón, Spain.
authors: Francisco
authors: F
authors: Vizoso
mesh_terms: D000818:Animals; D017209:Apoptosis; D049109:Cell Proliferation; D002471:Cell Transformation, Neoplastic; D002584:Cervix Uteri / Q000378:metabolism* / Q000473:pathology*; D004195:Disease Models, Animal; D058750:Epithelial-Mesenchymal Transition; D005260:Female; D006801:Humans; D008679:Metaplasia; D019899:Paracrine Communication; D013234:Stem Cells / Q000378:metabolism* / Q000473:pathology; D017154:Stromal Cells / Q000378:metabolism* / Q000473:pathology; D002583:Uterine Cervical Neoplasms / Q000378:metabolism / Q000401:mortality / Q000473:pathology
keywords: Stem cells; cervix; stromal cells; uterus