title: Biochemical Changes in Erythrocytes as a Molecular Marker of Cell Damage during Long-Term Simvastatin Treatment.
abstract: Long-term administration of simvastatin to rats, irrespective of the baseline cholesterol levels, induced biochemical changes in erythrocytes attesting to hypoxic damage (accumulation of lactate and 2,3-diphosphoglycerate), disturbances in ATP-dependent mechanisms of ion homeostasis regulation (decrease in total ATPase and Ca(2+)-ATPase activities), and antioxidant enzymes system imbalance. These changes can be considered as a sensitive indicator and molecular basis of cell damage during long-term administration of statins.
authors: Department of General and Clinical Biochemistry No. 1, Rostov State Medical University, Ministry of Health of the Russian Federation, Rostov-on-Don, Russia.
authors: Z I
authors: ZI
authors: Mikashinovich
authors: Department of Pharmaceutical Chemistry and Pharmacology, Rostov State Medical University, Ministry of Health of the Russian Federation, Rostov-on-Don, Russia. belousovalena@mail.ru.
authors: E S
authors: ES
authors: Belousova
mesh_terms: D019794:2,3-Diphosphoglycerate / Q000378:metabolism; D000818:Animals; D004912:Erythrocytes / Q000187:drug effects* / Q000378:metabolism*; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000009:adverse effects; D019344:Lactic Acid / Q000378:metabolism; D008297:Male; D051381:Rats; D019821:Simvastatin / Q000009:adverse effects*
chemical_list: D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D019794:2,3-Diphosphoglycerate; D019344:Lactic Acid; D019821:Simvastatin
keywords: hepatotoxicity; myopathy; side effects; statins