title: HAVcR-1 involvement in cancer progression.
abstract: Formerly known for its importance in the immune system and kidney regeneration, it is becoming more apparent that HAVcR-1 an important protein in cancer biology. HAVcR-1 is overexpressed in numerous cancers and associates with critical molecules of tight junctions. Tight junctions are critical in homeostasis of cellular compartments via the maintenance of epithelia and endothelia however it has also be suggested that via the prevention of dissemination, intravasation and extravasation, tight junctions play a critical role in the prevention of cancer metastasis. HAVcR-1 shedding and the production of the HAVcR-1 ectodomain has been linked to increased IL-6 thus implicated it in the process of angiogenesis via the activation of the STAT3 pathway leading to increased HIF-1α. The HAVcR-1 ectodomain has also been shown to be a potential urinary biomarker in certain cancers. HAVcR-1 is potentially important molecule both for the detection of cancer and the treatment of cancer by being a novel target for anti-cancer therapeutics.
authors: Cardiff China Medical Research Collaborative (CCMRC), (Cardiff University - Peking University Cancer Institute and Cardiff University - Capital Medical University Joint Centre Biomedical Research), Cardiff University, School of Medicine, Cardiff, United Kingdom.
authors: Emily J A
authors: EJ
authors: Telford
authors: Cardiff China Medical Research Collaborative (CCMRC), (Cardiff University - Peking University Cancer Institute and Cardiff University - Capital Medical University Joint Centre Biomedical Research), Cardiff University, School of Medicine, Cardiff, United Kingdom.
authors: Wen G
authors: WG
authors: Jiang
authors: Cardiff China Medical Research Collaborative (CCMRC), (Cardiff University - Peking University Cancer Institute and Cardiff University - Capital Medical University Joint Centre Biomedical Research), Cardiff University, School of Medicine, Cardiff, United Kingdom. MartinTA1@cardiff.ac.uk.
authors: Tracey A
authors: TA
authors: Martin
mesh_terms: D018450:Disease Progression; D000072596:Hepatitis A Virus Cellular Receptor 1 / Q000378:metabolism*; D006801:Humans; D051795:Hypoxia-Inducible Factor 1, alpha Subunit / Q000378:metabolism; D015850:Interleukin-6 / Q000378:metabolism; D009362:Neoplasm Metastasis / Q000473:pathology*; D009369:Neoplasms / Q000378:metabolism* / Q000473:pathology; D019108:Tight Junctions / Q000378:metabolism* / Q000473:pathology
chemical_list: C491143:HAVCR1 protein, human; D000072596:Hepatitis A Virus Cellular Receptor 1; D051795:Hypoxia-Inducible Factor 1, alpha Subunit; D015850:Interleukin-6