title: IGF2BP2rs11705701 polymorphisms are associated with prediabetes in a Chinese population: A population-based case-control study.
abstract: Associations between insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2) rs11705701, insulin receptor substrate 1 rs7578326, gastric inhibitory polypeptide receptor rs10423928 and transcription factor 7-like 2 rs12255372 gene polymorphisms with prediabetes and type 2 diabetes (T2D) have not been evaluated in the Han Chinese population. These four genetic variants were investigated for their associations with prediabetes and T2D among 490 unrelated patients with T2D, 471 patients with prediabetes and 575 healthy controls. Sequenom MassARRAY software was used to genotype the patients for these variants. The Generalized Multifactor Dimensionality Reduction method was used to analyze the gene-gene and gene-environment interactions. A breakdown analysis by gender revealed a significant association ofIGF2BP2rs11705701 with prediabetes under the dominant genetic model in females following application of the Bonferroni correction (odds ratio = 0.26; 95% confidence interval = 0.10-0.67; P=0.005). However, no significant associations were reported between any of the other three polymorphisms and T2D under any genetic models. Furthermore, there were no statistically significant gene-gene or gene-environment interactions when evaluated with the above association tests. The present case-control study reveals a significant association betweenIGF2BP2rs11705701 and prediabetes in female patients.
authors: Zhejiang Provincial Key Laboratory of Pathophysiology, School of Medicine, Ningbo University, Ningbo, Zhejiang 315211, P.R. China.
authors: Liyuan
authors: L
authors: Han
authors: Key Laboratory of Etiology and Epidemiology, Center for Endemic Disease Control, Chinese Center for Disease Control and Prevention, Harbin Medical University, Harbin, Heilongjiang 150081, P.R. China.
authors: Yuanyuan
authors: Y
authors: Li
authors: Zhejiang Provincial Key Laboratory of Pathophysiology, School of Medicine, Ningbo University, Ningbo, Zhejiang 315211, P.R. China.
authors: Linlin
authors: L
authors: Tang
authors: Shenzhen Nanshan Center for Chronic Disease Control, Shenzhen, Guangdong 518054, P.R. China.
authors: Zhongwei
authors: Z
authors: Chen
authors: Shenzhen Nanshan Center for Chronic Disease Control, Shenzhen, Guangdong 518054, P.R. China.
authors: Tao
authors: T
authors: Zhang
authors: Shenzhen Nanshan Center for Chronic Disease Control, Shenzhen, Guangdong 518054, P.R. China.
authors: Sihan
authors: S
authors: Chen
authors: Shenzhen Nanshan Center for Chronic Disease Control, Shenzhen, Guangdong 518054, P.R. China.
authors: Shengyuan
authors: S
authors: Liu
authors: Shenzhen Nanshan Center for Chronic Disease Control, Shenzhen, Guangdong 518054, P.R. China.
authors: Xiaolin
authors: X
authors: Peng
authors: Department of Endocrinology, The Affiliated Hospital of Ningbo Medical School, Ningbo University, Ningbo, Zhejiang 315000, P.R. China.
authors: Yifeng
authors: Y
authors: Mai
authors: Zhejiang Provincial Key Laboratory of Pathophysiology, School of Medicine, Ningbo University, Ningbo, Zhejiang 315211, P.R. China.
authors: Renjie
authors: R
authors: Zhuo
authors: Shenzhen Nanshan Center for Chronic Disease Control, Shenzhen, Guangdong 518054, P.R. China.
authors: Changyi
authors: C
authors: Wang
authors: Zhejiang Provincial Key Laboratory of Pathophysiology, School of Medicine, Ningbo University, Ningbo, Zhejiang 315211, P.R. China.
authors: Shiwei
authors: S
authors: Duan
keywords: gastric inhibitory polypeptide receptor; insulin receptor substrate 1; insulin-like growth factor 2 mRNA-binding protein 2; prediabetes; transcription factor 7-like 2; type 2 diabetes