title: Urinary C-type natriuretic peptide excretion: a promising biomarker to detect underlying renal injury and remodeling both acutely and chronically.
abstract: Acute kidney injury (AKI) refers to a sudden decline in renal function. A growing body of evidence demonstrates that AKI is a risk factor for the future development or accelerated progression of chronic kidney disease (CKD), whereas the actual distinction between AKI and CKD remains unknown. CNP is predominantly present in the kidney and possesses multiple renoprotective properties. Urinary CNP excretion tends to be high in AKI, whereas back to the baseline in CKD. The dynamic changes in urinary CNP excretion may help detect underlying renal injury and remodeling both acutely and chronically.
authors: Department of Pediatrics, The First Affiliated Hospital of Anhui Medical University, 218 Jixi Road, Hefei 230022, PR China.
authors: Peng
authors: P
authors: Hu
authors: Department of Pediatrics, The First Affiliated Hospital of Anhui Medical University, 218 Jixi Road, Hefei 230022, PR China.
authors: Si Yan
authors: SY
authors: Liu
authors: Department of Pediatrics, The First Affiliated Hospital of Anhui Medical University, 218 Jixi Road, Hefei 230022, PR China.
authors: Dong Dong
authors: DD
authors: Zhang
authors: Department of Pediatrics, The First Affiliated Hospital of Anhui Medical University, 218 Jixi Road, Hefei 230022, PR China.
authors: Yao
authors: Y
authors: Xu
authors: Department of Pediatrics, The First Affiliated Hospital of Anhui Medical University, 218 Jixi Road, Hefei 230022, PR China.
authors: Xun
authors: X
authors: Xia
mesh_terms: D058186:Acute Kidney Injury / Q000175:diagnosis* / Q000503:physiopathology; D015415:Biomarkers / Q000097:blood / Q000652:urine*; D002908:Chronic Disease; D003404:Creatinine / Q000097:blood; D055316:Cystatin C / Q000652:urine; D005919:Glomerular Filtration Rate; D000072596:Hepatitis A Virus Cellular Receptor 1 / Q000032:analysis; D006801:Humans; D020382:Interleukin-18 / Q000652:urine; D000071068:Lipocalin-2 / Q000652:urine; D020098:Natriuretic Peptide, C-Type / Q000652:urine*; D016016:Proportional Hazards Models
chemical_list: D015415:Biomarkers; D055316:Cystatin C; C491143:HAVCR1 protein, human; D000072596:Hepatitis A Virus Cellular Receptor 1; D020382:Interleukin-18; D000071068:Lipocalin-2; D020098:Natriuretic Peptide, C-Type; D003404:Creatinine
keywords: C-type natriuretic peptide; Cox regression analysis; acute kidney injury; renal tubulointerstitial fibrosis; serum creatinine