title: Efficacy of a Solution Composed by Verbascoside, Polyvinylpyrrolidone (PVP) and Sodium Hyaluronate in the Treatment of Chemotherapy-induced Oral Mucositis in Children With Acute Lymphoblastic Leukemia.
abstract: The aim of this study was to assess the efficacy of a solution composed by verbascoside, polyvinylpyrrolidone, and sodium hyaluronate (Mucosyte) in the treatment of chemotherapy-induced oral mucositi (OM). Patients between 5 and 18 years receiving chemotherapy for acute lymphoblastic leukemia and with OM grade 1 or 2 were randomized in group A (treated with Mucosyte, 3 mouthwashes/d per 8 d) and group B (treated with placebo, ie, an inert water-based solution, 3 mouthwashes/d per 8 d). The OM scoring was performed at day 1 (diagnosis of OM-T0), after 3 days of treatment (T1), and at day 8 (T2). Pain was evaluated through the visual analog scale with the same timing of OM measurement. A total of 56 patients were included (28 patients per group). Group A experienced a statistically significant decline of OM at T2 (P=0.0038); a statistically significant difference in pain reduction between 2 groups both at T1 and at T2 (P<0.005) was observed. The use of Mucosyte mouthwashes in children with chemotherapy-induced OM may be recommended as supportive therapy.
authors: *Department of Pediatric Dentistry, Dental Clinic, University of Brescia †Pediatric Oncology Unit of Spedali Civili di Brescia, Brescia, Italy.
authors: Elena
authors: E
authors: Bardellini
authors: Francesca
authors: F
authors: Amadori
authors: Richard Fabian
authors: RF
authors: Schumacher
authors: Carmelita
authors: C
authors: D'Ippolito
authors: Fulvio
authors: F
authors: Porta
authors: Alessandra
authors: A
authors: Majorana
mesh_terms: D000293:Adolescent; D000970:Antineoplastic Agents / Q000009:adverse effects*; D002648:Child; D002675:Child, Preschool; D004311:Double-Blind Method; D005960:Glucosides / Q000008:administration & dosage*; D006801:Humans; D006820:Hyaluronic Acid / Q000008:administration & dosage*; D010636:Phenols / Q000008:administration & dosage*; D011205:Povidone / Q000008:administration & dosage*; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy*; D012996:Solutions; D013280:Stomatitis / Q000139:chemically induced / Q000188:drug therapy*; D059808:Polyphenols
chemical_list: D000970:Antineoplastic Agents; D005960:Glucosides; D006820:Hyaluronic Acid; D010636:Phenols; D011205:Povidone; D012996:Solutions; C058956:acteoside; D059808:Polyphenols