title: Cross border semantic interoperability for clinical research: the EHR4CR semantic resources and services.
abstract: With the development of platforms enabling the use of routinely collected clinical data in the context of international clinical research, scalable solutions for cross border semantic interoperability need to be developed. Within the context of the IMI EHR4CR project, we first defined the requirements and evaluation criteria of the EHR4CR semantic interoperability platform and then developed the semantic resources and supportive services and tooling to assist hospital sites in standardizing their data for allowing the execution of the project use cases. The experience gained from the evaluation of the EHR4CR platform accessing to semantically equivalent data elements across 11 European participating EHR systems from 5 countries demonstrated how far the mediation model and mapping efforts met the expected requirements of the project. Developers of semantic interoperability platforms are beginning to address a core set of requirements in order to reach the goal of developing cross border semantic integration of data.
authors: INSERM, U1142, LIMICS, F-75006, Paris, France; Sorbonne Universités, UPMC Univ Paris 06, UMR_S 1142, LIMICS, F-75006, Paris, France;; AP-HP, Paris, France.
authors: Christel
authors: C
authors: Daniel
authors: INSERM, U1142, LIMICS, F-75006, Paris, France; Sorbonne Universités, UPMC Univ Paris 06, UMR_S 1142, LIMICS, F-75006, Paris, France;
authors: David
authors: D
authors: Ouagne
authors: INSERM, U1142, LIMICS, F-75006, Paris, France; Sorbonne Universités, UPMC Univ Paris 06, UMR_S 1142, LIMICS, F-75006, Paris, France;; AP-HP, Paris, France.
authors: Eric
authors: E
authors: Sadou
authors: AstraZeneca, Sweden;
authors: Kerstin
authors: K
authors: Forsberg
authors: Dundee University, UK.
authors: Mark Mc
authors: MM
authors: Gilchrist
authors: AP-HP, Paris, France.
authors: Eric
authors: E
authors: Zapletal
authors: AP-HP, Paris, France.
authors: Nicolas
authors: N
authors: Paris
authors: INSERM, U1142, LIMICS, F-75006, Paris, France; Sorbonne Universités, UPMC Univ Paris 06, UMR_S 1142, LIMICS, F-75006, Paris, France;
authors: Sajjad
authors: S
authors: Hussain
authors: INSERM, U1142, LIMICS, F-75006, Paris, France; Sorbonne Universités, UPMC Univ Paris 06, UMR_S 1142, LIMICS, F-75006, Paris, France;
authors: Marie-Christine
authors: MC
authors: Jaulent
authors: University College London, UK.
authors: Dipka
authors: D
authors: Kalra
keywords: Biomedical Research; Data Integration and Standardization; Electronic Health Records; Interoperability; Knowledge representation; Terminology as Topic