title: Free middle turbinate mucosal graft reconstruction after primary endoscopic endonasal pituitary surgery.
abstract: The objective is to assess whether free middle turbinate (FMT) graft reconstruction, after endoscopic endonasal pituitary surgery, combines an acceptably low post-operative cerebrospinal fluid (CSF) leak rate with acceptable rhinological morbidity. This study identified 50 patients who underwent endoscopic endonasal pituitary surgery by the senior author in our teaching hospital between May 2011 and June 2012. FMT graft reconstruction was used in 32 cases. 18 patients were judged pre-operatively as not suitable for FMT reconstruction according to a novel skull base reconstructive algorithm. Outcomes examined were: length of inpatient stay; post-operative CSF leak rate; volume of gross tumour resection; and rhinological morbidity. The rhinological morbidity was measured by the completion of the 22 item sinonasal outcome test (SNOT-22) questionnaire by all 32 patients at 6 weeks and 6 months post-surgery. 32 patients were included in the study. 9 patients had functioning microadenomas and 23 macroadenomas. The median inpatient stay was 2 days. There were no post-operative CSF leaks. The rate of gross tumour resection, confirmed on post-operative MRI, was 87.5 %. The mean SNOT-22 score was 31.9 at 6 weeks and 23.4 at 6 months post-operation-a statistically significant drop. The use of the FMT graft in the reconstruction of the sella defect after endonasal endoscopic pituitary surgery provides a robust dural repair with an acceptable rhinological morbidity profile. FMT grafting as part of a defined skull base reconstructive algorithm results in a CSF leak rate of zero and allows early patient discharge without the need for nasal packing or lumbar drains.
authors: Department of Otolaryngology, Cwm Taf University Health Board, Ynysmaerdy, Pontyclun, CF72 8XR, UK. samfishpool@gmail.com.
authors: Samuel J C
authors: SJ
authors: Fishpool
authors: Department of Neurosurgery, University Hospital of Wales, Cardiff, UK.
authors: Anthony
authors: A
authors: Amato-Watkins
authors: Department of Neurosurgery, University Hospital of Wales, Cardiff, UK.
authors: Caroline
authors: C
authors: Hayhurst
mesh_terms: D000236:Adenoma / Q000601:surgery*; D000328:Adult; D065634:Cerebrospinal Fluid Leak / Q000453:epidemiology / Q000209:etiology / Q000517:prevention & control; D005500:Follow-Up Studies; D058752:Free Tissue Flaps / Q000637:transplantation*; D006801:Humans; D007902:Length of Stay / Q000706:statistics & numerical data; D008297:Male; D057605:Natural Orifice Endoscopic Surgery; D010911:Pituitary Neoplasms / Q000601:surgery*; D011183:Postoperative Complications / Q000453:epidemiology / Q000517:prevention & control; D011446:Prospective Studies; D019651:Plastic Surgery Procedures / Q000379:methods*; D016896:Treatment Outcome
keywords: Cerebrospinal fluid; Endoscopic surgical procedures; Free tissue flaps; Pituitary gland; Quality of life