title: Neuromedin B receptor antagonism inhibits migration, invasion, and epithelial-mesenchymal transition of breast cancer cells.
abstract: Neuromedin B (NMB) acts as an autocrine growth factor and a pro-angiogenic factor. Its receptor, NMB receptor (NMB-R), is overexpressed in solid tumors. In the present study, we showed that an NMB-R antagonist, PD168368, suppresses migration and invasion of the human breast cancer cell line MDA-MB-231. In addition, PD168368 reduced epithelial-mesenchymal transition (EMT) of breast cancer cells by E-cadherin upregulation and vimentin downregulation. Moreover, we found that PD168368 potently inhibits in vivo metastasis of breast cancer. Taken together, these findings suggest that NMB-R antagonism may be an alternative approach to prevent breast cancer metastasis, and targeting NMB-R may provide a novel therapeutic strategy for breast cancer treatment.
authors: Department of Oral Physiology, School of Dentistry, Pusan National University, Yangsan 626-870, Republic of Korea.
authors: Hyun-Joo
authors: HJ
authors: Park
authors: Department of Oral Physiology, School of Dentistry, Pusan National University, Yangsan 626-870, Republic of Korea.
authors: Mi-Kyoung
authors: MK
authors: Kim
authors: Molecular and Cellular Imaging Center, Samsung Biomedical Research Institute, Sungkyunkwan University School of Medicine, Seoul 136‑710, Republic of Korea.
authors: Kyu-Sil
authors: KS
authors: Choi
authors: School of Medicine, Kyung Hee University, Seoul 130-701, Republic of Korea.
authors: Joo-Won
authors: JW
authors: Jeong
authors: Department of Dental Pharmacology, BK21 PLUS Project, School of Dentistry, Pusan National University, Yangsan 626-870, Republic of Korea.
authors: Soo-Kyung
authors: SK
authors: Bae
authors: Department of Oral Physiology, School of Dentistry, Pusan National University, Yangsan 626-870, Republic of Korea.
authors: Hyung Joon
authors: HJ
authors: Kim
authors: Department of Oral Physiology, School of Dentistry, Pusan National University, Yangsan 626-870, Republic of Korea.
authors: Moon-Kyoung
authors: MK
authors: Bae
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000494:pharmacology; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000235:genetics / Q000378:metabolism; D015820:Cadherins / Q000235:genetics / Q000378:metabolism; D045744:Cell Line, Tumor; D002465:Cell Movement / Q000187:drug effects; D058750:Epithelial-Mesenchymal Transition / Q000187:drug effects*; D005260:Female; D006801:Humans; D007211:Indoles / Q000008:administration & dosage* / Q000494:pharmacology; D061986:MCF-7 Cells; D051379:Mice; D009361:Neoplasm Invasiveness; D009362:Neoplasm Metastasis; D011725:Pyridines / Q000008:administration & dosage* / Q000494:pharmacology; D014746:Vimentin / Q000235:genetics / Q000378:metabolism; D023041:Xenograft Model Antitumor Assays
chemical_list: D000970:Antineoplastic Agents; D015820:Cadherins; D007211:Indoles; C419604:PD 168368; D011725:Pyridines; D014746:Vimentin