title: [Protective effects of oxycodone on lipopolysaccharide-induced acute lung injury in rats].
abstract: OBJECTIVE
  To analyze the role of oxycodone in acute lung injury(ALI) induced by lipopolysaccharide (LPS) in rats.
  
  
  METHODS
  Male SD rats were randomly allocated into 4 groups: control group, oxycodone group, LPS group, LPS+ oxycodone group. The effects of oxycodone on LPS-induced neutrophils influx, inflammatory cytokines release, pulmonary edema, apoptotic cell were examined. In addition, the toll-like receptor 4 (TLR4) in lung tissues was detected by Western blotting.
  
  
  RESULTS
  Oxycodone significantly attenuated LPS-induced pulmonary histopathologic changes, alveolar hemorrhage, and neutrophil infiltration. The lung wet-to-dry weight ratio, was markedly decreased by oxycodone(5.60±0.24 vs 6.80±0.27, P<0.05 ). Moreover, oxycodone decreased the productions of the inflammatory cytokines including IL-1β, TNF-α, HMGB-1((1 208±18)pg/ml, (1 660±14) pg/ml, (61±4) pg/ml , all P<0.05). Oxycodone treatment also reduced the concentration of apoptosis in lung tissues(18.6%±0.5%, P<0.05). Furthermore, the expression of TLR4 was significantly suppressed by oxycodone treatment in lung tissues(1.20±0.15, P<0.05).
  
  
  CONCLUSIONS
  Oxycodone exerts protective effects on LPS-induced ALI in rats. The potential mechanism of this action may attribute partly to the inhibition of TLR4 activation.
authors: Department of Thoracic Surgery, Tianjin First Central Hospital, Tianjin 300192, China.
authors: B
authors: B
authors: Yang
authors: W D
authors: WD
authors: Zhang
authors: Y M
authors: YM
authors: Xia
authors: Z P
authors: ZP
authors: Zhang
authors: L
authors: L
authors: Li
authors: L
authors: L
authors: Zhang
authors: W C
authors: WC
authors: Wang
authors: Z D
authors: ZD
authors: Wang
authors: X P
authors: XP
authors: Li
mesh_terms: D055371:Acute Lung Injury; D000818:Animals; D016207:Cytokines; D007249:Inflammation; D008070:Lipopolysaccharides; D008168:Lung; D008297:Male; D009504:Neutrophils; D010098:Oxycodone; D051381:Rats; D017207:Rats, Sprague-Dawley; D051197:Toll-Like Receptor 4
chemical_list: D016207:Cytokines; D008070:Lipopolysaccharides; C495347:Tlr4 protein, rat; D051197:Toll-Like Receptor 4; D010098:Oxycodone