title: Polyphenolic drug composition based on benzenepolycarboxylic acids (BP-C3) increases life span and inhibits spontaneous tumorigenesis in female SHR mice.
abstract: Effects of long-term application of novel polyphenolic composition BP-C3, containing polyphenolic benzenepolycarboxylic acids, vitamins and minerals on some biomarkers of aging, life span and spontaneous tumorigenesis has been studied in female SHR mice. Administration of BP-C3 with drinking water (0.005%) did not exert any toxic effect (did not have effect on general condition of animals, weight dynamics and consumption of food), postponed age-related switch-off of estrous function, caused slight reduction of body temperature. An increased survival was observed in mice treated with BP-C3 (p=0.00164, log rank test). BP-C3 increased mean lifespan - by 8.4%, lifespan of the last 10% of animals - by 12.4%, and life span of tumor-free mice - by 11.6%. A tendency in ability of BP-C3 to inhibit development of spontaneous tumors in mice was detected, though it did not reach the level of statistical significance (p=0.166, log rank test). The number of malignant mammary tumors was 1.5 times less and total number of tumors of various localizations was 1.6 times less in BP-C3 treated animals. Multiple tumors were registered in 8% of mice in the сontrol group and no cases - in BP-C3 treated group. Thus, BP-C3 demonstrated some anti-carcinogenic and a pronounced geroprotective activity.
authors: N.N. Petrov Research Institute of Oncology, Pesochny-2, Saint-Petersburg 197758, Russia.
authors: Vladimir N
authors: VN
authors: Anisimov
authors: N.N. Petrov Research Institute of Oncology, Pesochny-2, Saint-Petersburg 197758, Russia.
authors: Irina G
authors: IG
authors: Popovich
authors: N.N. Petrov Research Institute of Oncology, Pesochny-2, Saint-Petersburg 197758, Russia.
authors: Mark A
authors: MA
authors: Zabezhinski
authors: N.N. Petrov Research Institute of Oncology, Pesochny-2, Saint-Petersburg 197758, Russia.
authors: Maria N
authors: MN
authors: Yurova
authors: N.N. Petrov Research Institute of Oncology, Pesochny-2, Saint-Petersburg 197758, Russia.
authors: Margarita L
authors: ML
authors: Tyndyk
authors: N.N. Petrov Research Institute of Oncology, Pesochny-2, Saint-Petersburg 197758, Russia.
authors: Ivan V
authors: IV
authors: Anikin
authors: N.N. Petrov Research Institute of Oncology, Pesochny-2, Saint-Petersburg 197758, Russia.
authors: Peter A
authors: PA
authors: Egormin
authors: N.N. Petrov Research Institute of Oncology, Pesochny-2, Saint-Petersburg 197758, Russia.
authors: Irina A
authors: IA
authors: Baldueva
authors: N.N. Petrov Research Institute of Oncology, Pesochny-2, Saint-Petersburg 197758, Russia.|RD Pharm Ltd., Saint-Petersburg 192012, Russia.
authors: Elena I
authors: EI
authors: Fedoros
authors: N.N. Petrov Research Institute of Oncology, Pesochny-2, Saint-Petersburg 197758, Russia.|RD Pharm Ltd., Saint-Petersburg 192012, Russia.
authors: Sergey E
authors: SE
authors: Pigarev
authors: N.N. Petrov Research Institute of Oncology, Pesochny-2, Saint-Petersburg 197758, Russia.
authors: Andrey V
authors: AV
authors: Panchenko
mesh_terms: D000375:Aging / Q000187:drug effects*; D000818:Animals; D001831:Body Temperature / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects; D063646:Carcinogenesis / Q000187:drug effects*; D002471:Cell Transformation, Neoplastic / Q000187:drug effects; D030762:Estrous Cycle / Q000187:drug effects; D005260:Female; D008136:Longevity / Q000187:drug effects*; D051379:Mice; D059808:Polyphenols / Q000008:administration & dosage*
chemical_list: D059808:Polyphenols
keywords: biomarkers of aging; mice; polyphenolic compound BP-C3; spontaneous tumorigenesis