title: Undernutrition in the parental and first generation provokes an organ-specific response to oxidative stress on neonates of second filial generation of Wistar rats.
abstract: Undernutrition induces an increase of the oxidative stress that can predispose offspring to various diseases in adulthood through epigenetic reprogramming. The aim of this study was to evaluate the effects of intergenerational undernutrition on protein oxidation and antioxidant defence response on liver, heart and brain of the second-generation neonates (F2) of undernourished rats. For this purpose, both parents in parental (F0) and first generation (F1) were fed with a low-nutrient diet. Body mass and length decreased (p < 0.05) in F0, F1and F2being the F1males who exhibited a greater mass loss. A decrease in plasma albumin concentration was observed in F2neonates (p < 0.05) and also a mass loss of liver, heart and brain (p < 0.05), although proportionally to body length reduction. Undernutrition increased levels of protein oxidation in liver and heart (p < 0.05) but not in brain (p > 0.05) while catalase activity increased only in brain (p < 0.05). In summary, intergenerational undernutrition modifies the antioxidant status through an organ-specific response, on F2neonate rats, where the brain increased catalase activity to prevent a severe oxidative damage and support the vital functions of this key organ to maintain vital functions.
authors: Área Académica de Nutrición, Centro de Investigación Interdisciplinario, Instituto de Ciencias de la Salud, Universidad Autónoma del Estado de Hidalgo, Pachuca, Hidalgo, México.
authors: R
authors: R
authors: Baños-Gómez
authors: Área Académica de Nutrición, Centro de Investigación Interdisciplinario, Instituto de Ciencias de la Salud, Universidad Autónoma del Estado de Hidalgo, Pachuca, Hidalgo, México.
authors: N S
authors: NS
authors: Cruz-Cansino
authors: Área Académica de Nutrición, Centro de Investigación Interdisciplinario, Instituto de Ciencias de la Salud, Universidad Autónoma del Estado de Hidalgo, Pachuca, Hidalgo, México.
authors: T
authors: T
authors: Suarez-Diéguez
authors: Área Académica de Medicina, Centro de Investigación Interdisciplinario, Instituto de Ciencias de la Salud, Universidad Autónoma del Estado de Hidalgo, Pachuca, Hidalgo, México.
authors: C
authors: C
authors: Valadez-Vega
authors: Área Académica de Nutrición, Centro de Investigación Interdisciplinario, Instituto de Ciencias de la Salud, Universidad Autónoma del Estado de Hidalgo, Pachuca, Hidalgo, México.
authors: E
authors: E
authors: Ramírez-Moreno
authors: Área Académica de Nutrición, Centro de Investigación Interdisciplinario, Instituto de Ciencias de la Salud, Universidad Autónoma del Estado de Hidalgo, Pachuca, Hidalgo, México.
authors: E
authors: E
authors: Alanís-García
authors: Área Académica de Nutrición, Centro de Investigación Interdisciplinario, Instituto de Ciencias de la Salud, Universidad Autónoma del Estado de Hidalgo, Pachuca, Hidalgo, México.
authors: J A
authors: JA
authors: Ariza-Ortega
authors: Área Académica de Nutrición, Centro de Investigación Interdisciplinario, Instituto de Ciencias de la Salud, Universidad Autónoma del Estado de Hidalgo, Pachuca, Hidalgo, México.
authors: J J
authors: JJ
authors: Manríquez-Torres
authors: Unidad PET/CT Ciclotrón, Edificio de Investigación, Facultad de Medicina, Universidad Nacional Autónoma de México, Ciudad Universitaria, México city, México.
authors: E
authors: E
authors: Zamora-Romo
authors: Área Académica de Nutrición, Centro de Investigación Interdisciplinario, Instituto de Ciencias de la Salud, Universidad Autónoma del Estado de Hidalgo, Pachuca, Hidalgo, México.
authors: L
authors: http://orcid.org/0000-0002-3506-8393
authors: L
authors: Delgado-Olivares
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D001835:Body Weight; D005260:Female; D047109:Fetal Development / Q000502:physiology*; D048070:Fetal Nutrition Disorders / Q000503:physiopathology*; D008297:Male; D044342:Malnutrition; D018384:Oxidative Stress; D011247:Pregnancy; D039401:Prenatal Nutritional Physiological Phenomena / Q000502:physiology*; D051381:Rats; D017208:Rats, Wistar
keywords: catalase activity; intergenerational undernutrition; neonate rats; oxidative stress; protein carbonylation; second filial generation (F2)