title: Risk factors and clinical analysis of candidemia in very-low-birth-weight neonates.
abstract: Candidemia is the third leading cause of morbidity and mortality in preterm or very-low-birth-weight infants. The incidence and risk factors of candidemia in this population are poorly known in western China.
  
  
  
  A case-control retrospective study of candidemia was conducted from January 2012-November 2015 in the Liuzhou Maternity and Child Healthcare Hospital. Data were analyzed by univariate analysis and multivariate logistic regression.
  
  
  
  Forty-eight confirmed cases of candidemia were identified during the study period, indicating an incidence of 106.9 per 1,000 admissions of very-low-birth-weight infants. Candida albicans was the most common pathogen and was isolated in 39.6% of infants with candidemia. The mortality rate of the case group was 10.4% versus 2.1% in the control group (P = .128). The multivariable logistic regression model identified that carbapenem use (odds ratio [OR], 11.39; 95% confidence interval [CI], 3.28-39.54), total parenteral nutrition (OR, 10.16; 95% CI, 2.25-45.94), and prolonged hospitalization (OR, 1.04; 95% CI, 1.01-1.07) were all associated with the risk of developing neonatal candidemia.
  
  
  
  Very-low-birth-weight infants are at a significantly high risk of developing candidemia. The local neonatal intensive care unit management teams should effectively focus on decreasing the overall use of carbapenems, improving catheter care, removing catheters early, and shortening hospitalizations to reduce the incidence of candidemia.
authors: Department of Neonatology, Liuzhou Maternity and Child Healthcare Hospital, Liuzhou, China.
authors: Jinjian
authors: J
authors: Fu
authors: Department of Neonatology, Liuzhou Maternity and Child Healthcare Hospital, Liuzhou, China.
authors: Xingmin
authors: X
authors: Wang
authors: Department of Neonatology, Liuzhou Maternity and Child Healthcare Hospital, Liuzhou, China.
authors: Ba
authors: B
authors: Wei
authors: Department of Neonatology, Liuzhou Maternity and Child Healthcare Hospital, Liuzhou, China.
authors: Yongjiang
authors: Y
authors: Jiang
authors: Department of Neonatology, Liuzhou Maternity and Child Healthcare Hospital, Liuzhou, China. Electronic address: cjclzsfy@126.com.
authors: Jichang
authors: J
authors: Chen
mesh_terms: D002175:Candida / Q000145:classification / Q000302:isolation & purification*; D058387:Candidemia / Q000453:epidemiology* / Q000382:microbiology; D016022:Case-Control Studies; D002681:China / Q000453:epidemiology; D003428:Cross Infection / Q000453:epidemiology* / Q000382:microbiology; D005260:Female; D006776:Hospitals, Pediatric; D006801:Humans; D015994:Incidence; D007231:Infant, Newborn; D019102:Infant, Very Low Birth Weight; D017053:Infection Control / Q000379:methods; D008297:Male; D012189:Retrospective Studies; D012307:Risk Factors
keywords: Case-control study; Risk factors