title: Patient and operative factors associated with complications following adolescent idiopathic scoliosis surgery: an analysis of 36,335 patients from the Nationwide Inpatient Sample.
abstract: OBJECTIVE The aim of this study was to investigate the incidence of and factors associated with complications following idiopathic scoliosis surgery in adolescents. METHODS The Nationwide Inpatient Sample database was used to identify patients 10-18 years of age who had undergone spinal fusion for adolescent idiopathic scoliosis (AIS) from 2002 to 2011. Twenty-three unique in-hospital postoperative complications, including death, were examined. A series of logistic regressions was used to determine if any demographic, comorbid, or surgical parameter was associated with complication development. Results of multiple logistic regression analyses were reported as odds ratios with 95% confidence intervals. All analyses were performed after the application of discharge weights to produce national estimates. RESULTS A total of 36,335 patients met the study inclusion criteria, 7.6% of whom (95% CI 6.3%-8.9%) developed at least one in-hospital complication. The 3 most common complications were respiratory failure (3.47%), reintubation (1.27%), and implant related (1.14%). Major complications such as death, pancreatitis, disseminated intravascular coagulation, visual loss, spinal cord injury, cardiac arrest, sepsis, nerve root injury, deep vein thrombosis, pulmonary embolism, shock, malignant hyperthermia, myocardial infarction, and iatrogenic stroke each had an incidence ≤ 0.2%. On multiple logistic regression analysis, an increasing age (OR 0.80) was associated with significantly lower odds of complication development; patients who were male (OR 1.80) or who had anemia (OR 2.10), hypertension (OR 2.51), or hypothyroidism (OR 2.27) or underwent revision procedures (OR 5.55) were at a significantly increased risk for complication development. The rates of postoperative complications for posterior, anterior, and combined approaches were 6.7%, 10.0%, and 19.8%, respectively (p < 0.001). Length of fusion (< 8 vs ≥ 8 levels) was not associated with complication development (p = 0.311). CONCLUSIONS Analysis of 36,335 patients who had undergone surgery for AIS revealed that younger patients, male patients, patients with a history of anemia, hypertension, or hypothyroidism, as well as those undergoing revision or anterior or combined approaches may have higher rates of postoperative complications. However, the overall complication rate was low (7.6%), and major complications had a rate ≤ 0.2% for each event. These findings suggest that surgery for AIS remains relatively safe, and future prospective investigations may further help to decrease the postoperative morbidity rate.
authors: Departments of 1 Neurosurgery and.
authors: Rafael
authors: R
authors: De la Garza Ramos
authors: Departments of 1 Neurosurgery and.
authors: C Rory
authors: CR
authors: Goodwin
authors: Departments of 1 Neurosurgery and.
authors: Nancy
authors: N
authors: Abu-Bonsrah
authors: Orthopaedic Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland.
authors: Amit
authors: A
authors: Jain
authors: Orthopaedic Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland.
authors: Emily K
authors: EK
authors: Miller
authors: Departments of 1 Neurosurgery and.
authors: Nicole
authors: N
authors: Huang
authors: Orthopaedic Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland.
authors: Khaled M
authors: KM
authors: Kebaish
authors: Orthopaedic Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland.
authors: Paul D
authors: PD
authors: Sponseller
authors: Departments of 1 Neurosurgery and.
authors: Daniel M
authors: DM
authors: Sciubba
mesh_terms: D000293:Adolescent; D002648:Child; D005260:Female; D006760:Hospitalization / Q000639:trends*; D006801:Humans; D008297:Male; D011183:Postoperative Complications / Q000175:diagnosis / Q000453:epidemiology*; D012189:Retrospective Studies; D012307:Risk Factors; D012600:Scoliosis / Q000175:diagnosis / Q000453:epidemiology* / Q000601:surgery*; D014481:United States / Q000453:epidemiology
keywords: AIS = adolescent idiopathic scoliosis; DISCWT = discharge weight; DVT = deep vein thrombosis; NIS = Nationwide Inpatient Sample; Nationwide Inpatient Sample; PE = pulmonary embolism; SRS = Scoliosis Research Society; adolescent idiopathic scoliosis; complications; rhBMP-2 = recombinant human bone morphogenetic protein-2; spine; surgery