title: Weight for gestational age and metabolically healthy obesity in adults from the Haguenau cohort.
abstract: An obesity subphenotype, named 'metabolically healthy obese' (MHO) has been recently defined to characterise a subgroup of obese individuals with less risk for cardiometabolic abnormalities. To date no data are available on participants born with small weight for gestational age (SGA) and the risk of metabolically unhealthy obesity (MUHO).
  
  
  
  Assess the risk of MUHO in SGA versus appropriate for gestational age (AGA) adult participants.
  
  
  
  129 young obese individuals (body mass index ≥30 kg/m²) from data of an 8-year follow-up Haguenau cohort (France), were identified out of 1308 participants and were divided into 2 groups: SGA (n=72) and AGA (n=57). Metabolic characteristics were analysed and compared using unpaired t-test. The HOMA-IR index was determined for the population and divided into quartiles. Obese participants within the first 3 quartiles were considered as MHO and those in the fourth quartile as MUHO. Relative risks (RRs) and 95% CI for being MUHO in SGA versus AGA participants were computed.
  
  
  
  The SGA-obese group had a higher risk of MUHO versus the AGA-obese group: RR=1.27 (95% CI 1.10 to 1.6) independently of age and sex.
  
  
  
  In case of obesity, SGA might confer a higher risk of MUHO compared with AGA.
authors: INSERM, UMS 011, Villejuif, France.
authors: Joane
authors: J
authors: Matta
authors: Nutrition Department, Hôpital Européen Georges-Pompidou, Paris, France.
authors: Claire
authors: C
authors: Carette
authors: INSERM CIE 05 - Unité d'épidémiologie clinique, Hôpital Robert Debré, Paris, France.
authors: Claire
authors: C
authors: Levy Marchal
authors: INRA, UMR 1019, UNH, CRNH Auvergne, F-63000 CLERMONT-FERRAND, France Clermont Université, Université d'Auvergne, Unité de Nutrition Humaine, BP 10448, F-63000 CLERMONT-FERRAND, France.
authors: Julien
authors: J
authors: Bertrand
authors: INRA, UMR 1019, UNH, CRNH Auvergne, F-63000 CLERMONT-FERRAND, France Clermont Université, Université d'Auvergne, Unité de Nutrition Humaine, BP 10448, F-63000 CLERMONT-FERRAND, France.
authors: Mélanie
authors: M
authors: Pétéra
authors: INSERM, UMS 011, Villejuif, France Paris Descartes University, Paris, France.
authors: Marie
authors: M
authors: Zins
authors: INRA, UMR 1019, UNH, CRNH Auvergne, F-63000 CLERMONT-FERRAND, France Clermont Université, Université d'Auvergne, Unité de Nutrition Humaine, BP 10448, F-63000 CLERMONT-FERRAND, France.
authors: Estelle
authors: E
authors: Pujos-Guillot
authors: INRA, UMR 1019, UNH, CRNH Auvergne, F-63000 CLERMONT-FERRAND, France Clermont Université, Université d'Auvergne, Unité de Nutrition Humaine, BP 10448, F-63000 CLERMONT-FERRAND, France.
authors: Blandine
authors: B
authors: Comte
authors: INSERM, UMS 011, Villejuif, France Nutrition Department, Hôpital Européen Georges-Pompidou, Paris, France Paris Descartes University, Paris, France.
authors: Sébastien
authors: S
authors: Czernichow
mesh_terms: D000328:Adult; D001786:Blood Glucose / Q000378:metabolism; D001835:Body Weight; D015331:Cohort Studies; D005260:Female; D005602:France; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D007236:Infant, Small for Gestational Age; D007333:Insulin Resistance; D008297:Male; D000067329:Obesity, Metabolically Benign / Q000453:epidemiology*; D012307:Risk Factors; D055815:Young Adult
chemical_list: D001786:Blood Glucose
keywords: NUTRITION & DIETETICS; PUBLIC HEALTH