title: Circulating Non-coding RNA as Biomarkers in Colorectal Cancer.
abstract: Recent studies suggested that colorectal cancer influences the types and quantity of nucleic acids - especially microRNAs - detected in the bloodstream. Concentration of circulating (cell-free) microRNAs, and possibly of other non-coding RNAs, could therefore serve as valuable colorectal cancer biomarker and could deliver insight into the disease process. This chapter addresses the recent discoveries on circulating microRNA and long non-coding RNA as diagnostic or prognostic biomarkers in colorectal cancer.
authors: Department of Experimental, Diagnostic and Specialty Medicine - DIMES, University of Bologna, Bologna, Italy. manuela.ferracin@unibo.it.
authors: Manuela
authors: M
authors: Ferracin
authors: Department of Morphology, Surgery and Experimental Medicine, University of Ferrara, Ferrara, Italy.
authors: Laura
authors: L
authors: Lupini
authors: Department of Morphology, Surgery and Experimental Medicine, University of Ferrara, Ferrara, Italy.
authors: Alessandra
authors: A
authors: Mangolini
authors: Department of Morphology, Surgery and Experimental Medicine, University of Ferrara, Ferrara, Italy.
authors: Massimo
authors: M
authors: Negrini
mesh_terms: D014408:Biomarkers, Tumor / Q000097:blood* / Q000235:genetics; D015179:Colorectal Neoplasms / Q000175:diagnosis* / Q000235:genetics / Q000628:therapy; D055088:Early Detection of Cancer; D006801:Humans; D035683:MicroRNAs / Q000097:blood; D011379:Prognosis; D062085:RNA, Long Noncoding / Q000097:blood; D012334:RNA, Neoplasm / Q000097:blood*; D022661:RNA, Untranslated / Q000097:blood*
chemical_list: D014408:Biomarkers, Tumor; D035683:MicroRNAs; D062085:RNA, Long Noncoding; D012334:RNA, Neoplasm; D022661:RNA, Untranslated
keywords: Biomarkers; Colorectal cancer; Diagnostics; MicroRNA; Plasma; Serum