title: Diterpenes from Grangea maderaspatana.
abstract: Phytochemical investigation of the ethanolic extract of Grangea maderaspatana led to isolation of gramaderins A-D, together with thirteen known compounds. All isolates were assayed for their anti-inflammatory activities. Consequently, 5,7-dihydroxy-3,6,3',4',5'-pentamethoxyflavone and 5,3'-dihydroxy-3,6,7,4',5'-pentamethoxyflavone showed significant bioactivities by inhibiting superoxide anion generation. 8-Acetoxy-pentadeca-1,9Z,14-trien-4,6-diyne-3-ol also demonstrated potent inhibition on elastase release. The gramaderins A/C (β-alkyl linked γ-lactone) and gramaderins B/D (α-alkyl linked γ-lactone) co-exist in this plant material, of which the latter derivatives are few in nature. Gramaderins C/D possess a special linear dilactone diterpene skeleton, which never been reported.
authors: Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 807, Taiwan; Translational Research Center and Cancer Center, Kaohsiung Medical University Hospital, Kaohsiung 807, Taiwan.
authors: Fang-Rong
authors: FR
authors: Chang
authors: Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 807, Taiwan.
authors: Shih-Ting
authors: ST
authors: Huang
authors: Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan.
authors: Chih-Chuang
authors: CC
authors: Liaw
authors: Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 807, Taiwan; School of Pharmacy, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 807, Taiwan.
authors: Ming-Hong
authors: MH
authors: Yen
authors: Graduate Institute of Natural Products, School of Traditional Chinese Medicine, College of Medicine, and Chinese Herbal Medicine Research Team, Healthy Aging Research Center, Chang Gung University, Taoyuan 333, Taiwan; Research Center for Industry of Human Ecology and Graduate Institute of Health Industry Technology, Chang Gung University of Science and Technology, Taoyuan 333, Taiwan; Immunology Consortium, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan.
authors: Tsong-Long
authors: TL
authors: Hwang
authors: Department of Physical Therapy, Tzu-Hui Institute of Technology, Pingtung 926, Taiwan.
authors: Ching-Yeu
authors: CY
authors: Chen
authors: Translational Research Center and Cancer Center, Kaohsiung Medical University Hospital, Kaohsiung 807, Taiwan.
authors: Ming-Feng
authors: MF
authors: Hou
authors: Translational Research Center and Cancer Center, Kaohsiung Medical University Hospital, Kaohsiung 807, Taiwan.
authors: Shyng-Shiou
authors: SS
authors: Yuan
authors: Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 807, Taiwan; Research Center for Natural Products & Drug Development, Kaohsiung Medical University, Kaohsiung 807, Taiwan. Electronic address: jmb@kmu.edu.tw.
authors: Yuan-Bin
authors: YB
authors: Cheng
authors: Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 807, Taiwan; School of Pharmacy, College of Pharmacy, China Medical University, Taichung 404, Taiwan; Chinese Medicine Research and Development Center, China Medical University Hospital, Taichung 404, Taiwan; Center for Molecular Medicine, China Medical University Hospital, Taichung 404, Taiwan; Research Center for Chinese Herbal Medicine, China Medical University, Taichung 404, Taiwan. Electronic address: yachwu@mail.cmu.edu.tw.
authors: Yang-Chang
authors: YC
authors: Wu
mesh_terms: D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D019659:Asteraceae / Q000737:chemistry*; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D047309:Flavones / Q000737:chemistry; D007783:Lactones / Q000737:chemistry; D015394:Molecular Structure
chemical_list: C521155:5,3'-dihydroxy-3,6,7,4',5'-pentamethoxyflavone; D000893:Anti-Inflammatory Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D004224:Diterpenes; D047309:Flavones; D007783:Lactones; C000614494:gramaderin A; C000614496:gramaderin B
keywords: Anti-inflammatory; Asteraceae; Diterpenes; Grangea maderaspatana