title: European consensus-based (S2k) Guideline on the Management of Herpes Zoster - guided by the European Dermatology Forum (EDF) in cooperation with the European Academy of Dermatology and Venereology (EADV), Part 2: Treatment.
abstract: Herpes zoster (HZ, shingles) is a frequent medical condition which may severely impact the quality of life of affected patients. Different therapeutic approaches to treat acute HZ are available. The aim of this European project was the elaboration of a consensus-based guideline on the management of patients who present with HZ, considering different patient populations and different localizations. This interdisciplinary guideline aims at an improvement of the outcomes of the acute HZ management concerning disease duration, acute pain and quality of life of the affected patients and at a reduction in the incidence of postherpetic neuralgia (PHN) and other complications. The guideline development followed a structured and pre-defined process, considering the quality criteria for guidelines development as suggested by the AGREE II instrument. The steering group was responsible for the planning and the organization of the guideline development process (Division of Evidence-Based Medicine, dEBM). The expert panel was nominated by virtue of clinical expertise and/or scientific experience and included experts from the fields of dermatology, virology/infectiology, ophthalmology, otolaryngology, neurology and anaesthesiology. Recommendations for clinical practice were formally consented during the consensus conference, explicitly considering different relevant aspects. The guideline was approved by the commissioning societies after an extensive internal and external review process. In this second part of the guideline, therapeutic interventions have been evaluated. The expert panel formally consented recommendations for the treatment of patients with HZ (antiviral medication, pain management, local therapy), considering various clinical situations. Users of the guideline must carefully check whether the recommendations are appropriate for the context of intended application. In the setting of an international guideline, it is generally important to consider different national approaches and legal circumstances with regard to the regulatory approval, availability and reimbursement of diagnostic and therapeutic interventions.
authors: Department of Dermatology, Venereology and Allergology, Division of Evidence-Based Medicine in Dermatology (dEBM), Charité - Universitätsmedizin Berlin, Berlin, Germany.
authors: R N
authors: RN
authors: Werner
authors: Department of Dermatology, University Medical Center of Liège, Liège, Belgium.
authors: A F
authors: AF
authors: Nikkels
authors: Department of Dermatology and Venereology, University Hospital Center Zagreb, University of Zagreb School of Medicine, Zagreb, Croatia.
authors: B
authors: B
authors: Marinović
authors: Department of Anesthesiology, Charité - Universitätsmedizin Berlin, Berlin, Germany.
authors: M
authors: M
authors: Schäfer
authors: Department of Dermatology, Poznan University of Medical Sciences, Poznan, Poland.
authors: M
authors: M
authors: Czarnecka-Operacz
authors: Department of Otorhinolaryngology, The Medical School, University of Malta, Msida, Malta.
authors: A M
authors: AM
authors: Agius
authors: Department of Dermatology and Allergology, University of Szeged, Szeged, Hungary.
authors: Z
authors: Z
authors: Bata-Csörgő
authors: Division of Infection and Immunity, University College London, London, United Kingdom.
authors: J
authors: J
authors: Breuer
authors: Department of Medicine, Section of Dermatology and Venereology, University of Verona, Verona, Italy.
authors: G
authors: G
authors: Girolomoni
authors: Department of Dermatology and Venerology, Universitätsklinik Rostock, Rostock, Germany.
authors: G E
authors: GE
authors: Gross
authors: Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, UK.
authors: S
authors: S
authors: Langan
authors: Department of Ophthalmology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.
authors: R
authors: R
authors: Lapid-Gortzak
authors: Department of Otolaryngology, University Hospital Aintree NHS Foundation Trust, Liverpool, UK.
authors: T H
authors: TH
authors: Lesser
authors: Department of Ophthalmology, Charité - Universitätsmedizin Berlin, Berlin, Germany.
authors: U
authors: U
authors: Pleyer
authors: Department of Neurology, Christian Doppler Medical Center, Paracelsus Medical University, Salzburg, Austria.
authors: J
authors: J
authors: Sellner
authors: Department of Viroscience, Erasmus MC, Rotterdam, The Netherlands.
authors: G M
authors: GM
authors: Verjans
authors: Department of Virology and Antiviral Therapy, Jena University Hospital, Jena, Germany.
authors: P
authors: P
authors: Wutzler
authors: Department of Dermatology, Venereology and Allergology, Division of Evidence-Based Medicine in Dermatology (dEBM), Charité - Universitätsmedizin Berlin, Berlin, Germany.
authors: C
authors: C
authors: Dressler
authors: Department of Dermatology, Venereology and Allergology, Division of Evidence-Based Medicine in Dermatology (dEBM), Charité - Universitätsmedizin Berlin, Berlin, Germany.
authors: R
authors: R
authors: Erdmann
authors: Department of Dermatology, Venereology and Allergology, Division of Evidence-Based Medicine in Dermatology (dEBM), Charité - Universitätsmedizin Berlin, Berlin, Germany.
authors: S
authors: S
authors: Rosumeck
authors: Department of Dermatology, Venereology and Allergology, Division of Evidence-Based Medicine in Dermatology (dEBM), Charité - Universitätsmedizin Berlin, Berlin, Germany.
authors: A
authors: A
authors: Nast
mesh_terms: D015075:2-Aminopurine / Q000031:analogs & derivatives / Q000627:therapeutic use; D000212:Acyclovir / Q000627:therapeutic use; D000700:Analgesics / Q000627:therapeutic use; D000998:Antiviral Agents / Q000627:therapeutic use*; D002648:Child; D005060:Europe; D000077595:Famciclovir; D005260:Female; D006562:Herpes Zoster / Q000188:drug therapy* / Q000503:physiopathology; D006563:Herpes Zoster Ophthalmicus / Q000188:drug therapy; D006801:Humans; D059408:Pain Management / Q000379:methods; D010147:Pain Measurement; D011247:Pregnancy; D011248:Pregnancy Complications / Q000188:drug therapy; D011788:Quality of Life; D012955:Societies, Medical
chemical_list: D000700:Analgesics; D000998:Antiviral Agents; D015075:2-Aminopurine; D000077595:Famciclovir; D000212:Acyclovir