title: [Biochemical and immunological markers of autoimmune thyroiditis].
abstract: Correlations between biochemical and immunological markers of programmed cell death (apoptosis), and the functional state of the thyroid gland (hyperthyroidism, euthyroidism, hypothyroidism) have been investigated in autoimmune thyroiditis (AT) (also known as chronic autoimmune thyroiditis). Annexin V, TRAIL and TNF-a, as well as DNA-hydrolyzing antibodies were used as the main markers. Increased levels of TRAIL were found in the serum of AT patients (hyperthyroidism>hypothyroidism>euthyroidism) compared with healthy individuals. The highest frequency of antibodies to denatured DNA (Abs-dDNA) had the highest frequency in AT patients (97%) compared with healthy controls. Among these patients, 75% had hyperthyroidism, 85% had hypothyroidism, and 84.7% had euthyroidism. Abs hydrolyzing activity demonstrated correlation dependence with symptoms of the thyroid dysfunction.
authors: Kazan (Volga Region) Federal University, Institute of Basic Medicine and Biology, Kazan, Russia.
authors: E M
authors: EM
authors: Biktagirova
authors: Interregional Clinical Diagnostic Center, Kazan, Russia.
authors: L I
authors: LI
authors: Sattarova
authors: Kazan State Medical Academy, Kazan, Russia.
authors: G R
authors: GR
authors: Vagapova
authors: Kazan (Volga Region) Federal University, Institute of Basic Medicine and Biology, Kazan, Russia.
authors: Y V
authors: YV
authors: Skibo
authors: Kazan (Volga Region) Federal University, Institute of Basic Medicine and Biology, Kazan, Russia.
authors: E N
authors: EN
authors: Chuhlovina
authors: Kazan (Volga Region) Federal University, Institute of Basic Medicine and Biology, Kazan, Russia.
authors: O A
authors: OA
authors: Kravtsova
authors: Kazan (Volga Region) Federal University, Institute of Basic Medicine and Biology, Kazan, Russia.
authors: Z I
authors: ZI
authors: Abramova
mesh_terms: D000328:Adult; D017304:Annexin A5 / Q000097:blood; D017209:Apoptosis; D001323:Autoantibodies / Q000097:blood; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D004247:DNA / Q000276:immunology; D005260:Female; D006801:Humans; D008875:Middle Aged; D018124:Receptors, Tumor Necrosis Factor / Q000097:blood; D013961:Thyroid Gland / Q000276:immunology*; D013967:Thyroiditis, Autoimmune / Q000097:blood* / Q000276:immunology; D014409:Tumor Necrosis Factor-alpha / Q000097:blood
chemical_list: D017304:Annexin A5; D001323:Autoantibodies; D015415:Biomarkers; D018124:Receptors, Tumor Necrosis Factor; D014409:Tumor Necrosis Factor-alpha; D004247:DNA
keywords: antibodies to DNA; apoptosis; autoantibodies; autoimmune thyroiditis