title: Neuroendocrine carcinoma of the extrahepatic bile duct: A case report.
abstract: Neuroendocrine carcinoma (NEC) originating from the gastrointestinal hepatobiliary-pancreas is a rare, invasive, and progressive disease, for which the prognosis is extremely poor. The patient was a 72-year-old man referred with complaints of jaundice. He was diagnosed with middle extrahepatic cholangiocarcinoma (cT4N1M0, cStage IV). He underwent a right hepatectomy combined with extrahepatic bile duct and portal vein resection after percutaneous transhepatic portal vein embolization. Microscopic examination showed a large-cell neuroendocrine carcinoma according to the WHO criteria for the clinicopathologic classification of gastroenteropancreatic neuroendocrine tumors. Currently, the patient is receiving combination chemotherapy with cisplatin and etoposide for postoperative multiple liver metastases. Although NEC is difficult to diagnose preoperatively, it should be considered an uncommon alternative diagnosis.
authors: Yukio Oshiro, Ryozo Gen, Shinji Hashimoto, Tatsuya Oda, Nobuhiro Ohkohchi, Department of Gastrointestinal and Hepato-Biliary-Pancreatic Surgery, Faculty of Medicine, University of Tsukuba, Tsukuba 305-8575, Japan.
authors: Yukio
authors: Y
authors: Oshiro
authors: Yukio Oshiro, Ryozo Gen, Shinji Hashimoto, Tatsuya Oda, Nobuhiro Ohkohchi, Department of Gastrointestinal and Hepato-Biliary-Pancreatic Surgery, Faculty of Medicine, University of Tsukuba, Tsukuba 305-8575, Japan.
authors: Ryozo
authors: R
authors: Gen
authors: Yukio Oshiro, Ryozo Gen, Shinji Hashimoto, Tatsuya Oda, Nobuhiro Ohkohchi, Department of Gastrointestinal and Hepato-Biliary-Pancreatic Surgery, Faculty of Medicine, University of Tsukuba, Tsukuba 305-8575, Japan.
authors: Shinji
authors: S
authors: Hashimoto
authors: Yukio Oshiro, Ryozo Gen, Shinji Hashimoto, Tatsuya Oda, Nobuhiro Ohkohchi, Department of Gastrointestinal and Hepato-Biliary-Pancreatic Surgery, Faculty of Medicine, University of Tsukuba, Tsukuba 305-8575, Japan.
authors: Tatsuya
authors: T
authors: Oda
authors: Yukio Oshiro, Ryozo Gen, Shinji Hashimoto, Tatsuya Oda, Nobuhiro Ohkohchi, Department of Gastrointestinal and Hepato-Biliary-Pancreatic Surgery, Faculty of Medicine, University of Tsukuba, Tsukuba 305-8575, Japan.
authors: Taiki
authors: T
authors: Sato
authors: Yukio Oshiro, Ryozo Gen, Shinji Hashimoto, Tatsuya Oda, Nobuhiro Ohkohchi, Department of Gastrointestinal and Hepato-Biliary-Pancreatic Surgery, Faculty of Medicine, University of Tsukuba, Tsukuba 305-8575, Japan.
authors: Nobuhiro
authors: N
authors: Ohkohchi
mesh_terms: D000368:Aged; D001650:Bile Duct Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology / Q000628:therapy*; D017734:Bile Ducts, Extrahepatic; D018278:Carcinoma, Neuroendocrine / Q000000981:diagnostic imaging / Q000473:pathology / Q000628:therapy*; D003131:Combined Modality Therapy; D006801:Humans; D008297:Male
keywords: Extrahepatic bile duct; Neuroendocrine carcinoma; Neuroendocrine tumor