title: Human brain responses to gastrointestinal nutrients and gut hormones.
abstract: Functional mapping of human brain activation has made it possible to understand how different nutrients in the gut impact on homeostatic and appetitive brain responses. Current data are limited, but nutrient-specific effects are observed, with differential responses to lipid and sugars. Responses are not a simple function of calorie intake. Gut hormones such as CCK, PYY, GLP-1 and ghrelin are implicated in these responses, but may not exert effects directly on the brain. Research is now addressing how these homeostatic signalling states (fasting/fed) interact with hedonic responses, such as those evoked by images of appealing food. Differences are also beginning to emerge in obese versus lean subjects. These platforms will enable a new understanding of normal and disordered eating behaviours in humans.
authors: University of Manchester, Manchester Academic Health Sciences Centre (MAHSC), and Gastrointestinal Centre, Institute of Inflammation and Repair, Faculty of Medical and Human Sciences, University of Manchester, UK. Electronic address: John.Mclaughlin@manchester.ac.uk.
authors: John T
authors: JT
authors: McLaughlin
authors: University of Manchester, Manchester Academic Health Sciences Centre (MAHSC), and Neuroscience and Psychiatry Unit, Institute of Brain, Behaviour and Mental Health, University of Manchester, UK.
authors: Shane
authors: S
authors: McKie
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism*; D001931:Brain Mapping; D004435:Eating / Q000502:physiology; D001068:Feeding and Eating Disorders / Q000503:physiopathology; D005502:Food; D005768:Gastrointestinal Hormones / Q000378:metabolism*; D006706:Homeostasis; D006801:Humans; D009765:Obesity / Q000503:physiopathology
chemical_list: D005768:Gastrointestinal Hormones