title: Prevalence of human papillomavirus infection and genotyping for population-based cervical screening in developed regions in China.
abstract: We conducted a cross-sectional analysis to assess the distribution of human papillomavirus (HPV) types and explored an acceptable strategy for cervical screening in Shenzhen, China. A total of 2717 individuals ranging in age from 30-59 years were recruited. Clinical sensitivity and specificity as well as positive (PPV) and negative (NPV) predictive values were estimated. A triage strategy was regarded as acceptable when the NPV was at least 98.0%. 432 (15.9%) participants presented HPV positive. The five most prevalent HPV types were HPV52 (22.9%), HPV16 (12.7%), HPV53 (10.0%), HPV51 (8.6%), and HPV58 (8.1%). The CIN2+ risks for each HPV type were 40.0% for HPV33, 32.4% for HPV16, 18.2% for HPV58, 13.3% for HPV56, and 11.1% for HPV68 in descending order. Baseline cytology testing combined with HPV16/33/52/58 genotyping met the NPV thresholds at 98.6% with a PPV of 17.9%, demonstrating excellent clinical performance for detecting HPV types in CIN2+ patients. In conclusion, triaging HPV-positive women by baseline cytology combined with HPV16/58/33/52 genotyping is an acceptable strategy for cervical cancer screening in Shenzhen, China.
authors: Department of Epidemiology and Biostatistics, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, 430030 Wuhan, Hubei, P.R. China.
authors: Yanru
authors: Y
authors: Zhang
authors: Shenzhen Maternity and Child Health Hospitals, 518000 Shenzhen, Guangdong, P. R. China.
authors: Yueyun
authors: Y
authors: Wang
authors: Department of Epidemiology and Biostatistics, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, 430030 Wuhan, Hubei, P.R. China.
authors: Li
authors: L
authors: Liu
authors: Department of Epidemiology and Biostatistics, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, 430030 Wuhan, Hubei, P.R. China.
authors: Chun
authors: C
authors: Guo
authors: Shenzhen Maternity and Child Health Hospitals, 518000 Shenzhen, Guangdong, P. R. China.
authors: Zhihua
authors: Z
authors: Liu
authors: Department of Epidemiology and Biostatistics, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, 430030 Wuhan, Hubei, P.R. China.
authors: Shaofa
authors: S
authors: Nie
mesh_terms: D000328:Adult; D052685:Alphapapillomavirus / Q000235:genetics* / Q000302:isolation & purification; D001706:Biopsy; D002584:Cervix Uteri / Q000473:pathology; D002681:China / Q000453:epidemiology; D003127:Colposcopy; D003430:Cross-Sectional Studies; D055088:Early Detection of Cancer / Q000379:methods*; D005260:Female; D005838:Genotype; D006801:Humans; D008875:Middle Aged; D030361:Papillomavirus Infections / Q000175:diagnosis / Q000453:epidemiology* / Q000235:genetics / Q000821:virology; D011237:Predictive Value of Tests; D015995:Prevalence; D012680:Sensitivity and Specificity; D002583:Uterine Cervical Neoplasms / Q000175:diagnosis / Q000453:epidemiology* / Q000235:genetics / Q000821:virology; D002578:Uterine Cervical Dysplasia / Q000175:diagnosis / Q000453:epidemiology* / Q000235:genetics / Q000821:virology
keywords: China; cervical screening; genotype; human papillomavirus; prevalence