title: The Natural Occurring Compounds Targeting Endoplasmic Reticulum Stress.
abstract: ER stress has been implicated in pathophysiological development of many diseases. Persistent overwhelming stimuli trigger ER stress to initiate apoptosis, autophagy, and cell death. IRE1-JNK and eIF2α-CHOP signaling pathways are the two important players of ER stress, which is also modulated by ROS production, calcium disturbance, and inflammatory factors. ER stress has been developed as a novel strategy for diseases management. Recently, a vast of research focuses on the natural occurring compounds targeting ER stress, which results in medical benefits to human diseases. These small reported molecules mainly include polyphenols, alkaloids, and saponins. Many of them have been developed for use in clinical applications. To better understand the pharmacological mechanism of these molecules in ER stress in diseases, efforts have been made to discover and deliver medical merits. In this paper, we will summarize the natural occurring compounds targeting ER stress.
authors: College of Pharmacy, Gannan Medical University, Ganzhou 341000, China.
authors: Hai
authors: H
authors: Liu
authors: Department of Clinical Research Center, The First Affiliated Hospital, Gannan Medical University, Ganzhou 341000, China.
authors: Jianqiong
authors: J
authors: Yang
authors: College of Pharmacy, Gannan Medical University, Ganzhou 341000, China.
authors: Linfu
authors: L
authors: Li
authors: College of Pharmacy, Gannan Medical University, Ganzhou 341000, China.
authors: Weimei
authors: W
authors: Shi
authors: Department of Respiratory Medicine, The First Affiliated Hospital, Gannan Medical University, Ganzhou 341000, China.
authors: Xiaoliang
authors: 0000-0003-2479-0361
authors: X
authors: Yuan
authors: College of Pharmacy, Gannan Medical University, Ganzhou 341000, China.
authors: Longhuo
authors: 0000-0002-3899-9599
authors: L
authors: Wu