title: [Cross-reactivity in allergic fungal sinusitis. Case report].
abstract: The presence of allergic mucin in allergic fungal sinusitis (AFS) is a manifestation that identifies it as a hypersensitivity process. AFS has a phenomenon of cross-reactivity to IgE-bound proteins having at least two shared epitopes.
  
  
  
  A 13-year-old male with nasal obstructive symptoms of three years of evolution. An obstructive mass was identified in the sinuses through physical examination and CT. In endoscopic surgery, the left nostril polyp was identified with the macroscopic appearance of allergic mucin; the polyp was resected. Final histopathological examination using periodic acid-Schiff and Grocott's methenamine silver staining indicated Aspergillus. Two weeks after surgery, percutaneous tests showed sensitization to Alternaria, Helminthosporium sativum, and Deramatophagoides farianae with negativity to Aspergillus fumigatus.
  
  
  
  The absence of significant titers of specific IgE antibodies to Aspergillus fumigatus was the evidence that the hypersensitivity response was triggered by a pathogen other than that isolated in histopathological study, which coupled with positive tests for other fungi may be explained by the cross-reactivity phenomenon in a phenomenon of likely hypersensitivity.
authors: Universidad Autónoma de Nuevo León. Centro Regional de Alergia e Inmunología Clínica, Monterrey, Nuevo León, México. dumariar@gmail.com.
authors: Sandra Nora
authors: SN
authors: González-Díaz
authors: Alfredo
authors: A
authors: Arias-Cruz
authors: Dulce María
authors: DM
authors: Rivero-Arias
authors: Alma Belén
authors: AB
authors: Partida-Ortega
authors: Bárbara
authors: B
authors: Elizondo-Villarreal
authors: Jesús Arturo
authors: JA
authors: Ibarra-Chávez
authors: Lissette
authors: L
authors: Ramos-Valencia
authors: Olga Patricia
authors: OP
authors: Monge-Ortega
authors: Carlos
authors: C
authors: Macouzet-Sánchez
authors: María Rocío
authors: MR
authors: Salinas-Díaz
mesh_terms: D000293:Adolescent; D000528:Alternaria / Q000276:immunology; D000818:Animals; D001232:Aspergillus fumigatus / Q000276:immunology; D003429:Cross Reactions / Q000276:immunology*; D040001:Dermatophagoides farinae / Q000276:immunology; D006375:Helminthosporium / Q000276:immunology; D006801:Humans; D006967:Hypersensitivity / Q000276:immunology*; D007073:Immunoglobulin E / Q000276:immunology*; D008297:Male; D012852:Sinusitis / Q000276:immunology*
chemical_list: D007073:Immunoglobulin E
keywords: Allergic fungal sinusitis; Aspergillus; Corticosteroids; Rhinosinusitis