title: Magnetically-induced elimination of Staphylococcus aureus by magnetotactic bacteria under a swing magnetic field.
abstract: This study aims to explore a therapeutic tool that kills pathogens by using mechanical force other than temperature. We fabricated a device that generates a swing magnetic field (sMF) with low-heat production and then evaluated the killing effect of magnetotactic bacteria MO-1 on Staphylococcus aureus (S. aureus) under the sMF. S. aureus was only killed under the sMF when attached to MO-1 cells. The killing efficiency increased with increasing attachment ratio of MO-1 cells to S. aureus. Treatment with antibody-coated MO-1 cells under the sMF improved the healing of S. aureus-infected wound. The theoretical analysis demonstrated that MO-1 cells generated a mechanical force of approximately 8kPa under the sMF, thereby exerting on S. aureus and inducing cell death. The proposed platform, which uses magnetotactic bacteria under the sMF to generate mechanical force, provides a basis for development of therapeutic tools to treat infectious diseases.
authors: Beijing Key Laboratory of Bioelectromagnetism, Institute of Electrical Engineering, Chinese Academy of Sciences, No. 6 Bei'er Tiao Zhongguancun HaiDian, Beijing, 100190, China; University of Chinese Academy of Sciences, No.19A Yuquanlu, Beijing, 100049, China; France-China Bio-Mineralization and Nano-Structures Laboratory, No. 6 Bei'er Tiao Zhongguancun HaiDian, Beijing, 100190, China. Electronic address: chchy@mail.iee.ac.cn.
authors: Changyou
authors: C
authors: Chen
authors: Beijing Key Laboratory of Bioelectromagnetism, Institute of Electrical Engineering, Chinese Academy of Sciences, No. 6 Bei'er Tiao Zhongguancun HaiDian, Beijing, 100190, China; University of Chinese Academy of Sciences, No.19A Yuquanlu, Beijing, 100049, China; France-China Bio-Mineralization and Nano-Structures Laboratory, No. 6 Bei'er Tiao Zhongguancun HaiDian, Beijing, 100190, China. Electronic address: chenlinjie09@mail.iee.ac.cn.
authors: Linjie
authors: L
authors: Chen
authors: Beijing Key Laboratory of Bioelectromagnetism, Institute of Electrical Engineering, Chinese Academy of Sciences, No. 6 Bei'er Tiao Zhongguancun HaiDian, Beijing, 100190, China; France-China Bio-Mineralization and Nano-Structures Laboratory, No. 6 Bei'er Tiao Zhongguancun HaiDian, Beijing, 100190, China. Electronic address: wangpp@mail.iee.ac.cn.
authors: Pingping
authors: P
authors: Wang
authors: France-China Bio-Mineralization and Nano-Structures Laboratory, No. 6 Bei'er Tiao Zhongguancun HaiDian, Beijing, 100190, China; Laboratoire de Chimie Bactérienne, UMR7283, Aix-Marseille University, Institut de Microbiologie de la Méditerranée, CNRS, Marseille, France. Electronic address: wu@imm.cnrs.fr.
authors: Long-Fei
authors: LF
authors: Wu
authors: Beijing Key Laboratory of Bioelectromagnetism, Institute of Electrical Engineering, Chinese Academy of Sciences, No. 6 Bei'er Tiao Zhongguancun HaiDian, Beijing, 100190, China; University of Chinese Academy of Sciences, No.19A Yuquanlu, Beijing, 100049, China; France-China Bio-Mineralization and Nano-Structures Laboratory, No. 6 Bei'er Tiao Zhongguancun HaiDian, Beijing, 100190, China. Electronic address: songtao@mail.iee.ac.cn.
authors: Tao
authors: T
authors: Song
mesh_terms: D000818:Animals; D006090:Gram-Negative Bacteria; D060526:Magnetic Fields; D008280:Magnetics / Q000379:methods*; D051379:Mice; D013203:Staphylococcal Infections / Q000628:therapy*; D013211:Staphylococcus aureus; D014946:Wound Infection
keywords: Magnetic hyperthermia; Magnetotactic bacteria; Mechanical force; Staphylococcus aureus; Swing magnetic field