title: Synthesis, characterization and drug release properties of 3D chitosan/clinoptilolite biocomposite cryogels.
abstract: Three-dimensional (3D) biocomposites based on chitosan (CS) and clinoptilolite (CPL) were prepared by cryogelation and their potential application as drug carriers was investigated. Variation of CPL content from 0 to 33wt.% allowed the formation of biocomposites with heterogeneous morphologies consisting of randomly distributed pores. The further increase of CPL content led to ordered porous architectures where parallel pore channels were observed. The CPL content had a strong influence on water uptake, as well as on the cumulative release of diclofenac sodium (DS) and indomethacin (IDM). It was demonstrated that the drug delivery preferentially takes place in phosphate buffer saline (pH 7.4) in comparison to simulated gastric fluid (pH 1.2), where only a reduced drug release was observed. The drug release mechanism dominating these systems is described as a pseudo-Fickian diffusion, but it changes to non-Fickian release when 33wt.% of CPL was entrapped into the CS matrix or when IDM was loaded into biocomposites.
authors: "Petru Poni" Institute of Macromolecular Chemistry, Department of Functional Polymers, Grigore Ghica Voda Alley 41A, Iasi 700487, Romania.
authors: Maria Valentina
authors: MV
authors: Dinu
authors: "Petru Poni" Institute of Macromolecular Chemistry, Department of Functional Polymers, Grigore Ghica Voda Alley 41A, Iasi 700487, Romania.
authors: Ana Irina
authors: AI
authors: Cocarta
authors: "Petru Poni" Institute of Macromolecular Chemistry, Department of Functional Polymers, Grigore Ghica Voda Alley 41A, Iasi 700487, Romania. Electronic address: sdragan@icmpp.ro.
authors: Ecaterina Stela
authors: ES
authors: Dragan
mesh_terms: D002236:Carbohydrate Conformation; D048271:Chitosan / Q000737:chemistry*; D059985:Cryogels / Q000138:chemical synthesis / Q000737:chemistry*; D004008:Diclofenac / Q000737:chemistry; D004058:Diffusion; D004337:Drug Carriers / Q000138:chemical synthesis / Q000737:chemistry*; D065546:Drug Liberation; D006863:Hydrogen-Ion Concentration; D007213:Indomethacin / Q000737:chemistry; D016062:Porosity; D014867:Water / Q000737:chemistry; D017641:Zeolites / Q000737:chemistry*
chemical_list: D059985:Cryogels; D004337:Drug Carriers; D014867:Water; C083175:clinoptilolite; D017641:Zeolites; D004008:Diclofenac; D048271:Chitosan; D007213:Indomethacin
keywords: Biocomposites; Chitosan; Clinoptilolite; Controlled drug release; Cryogels; Diclofenac sodium