title: Cerebral Venous Thrombosis: A Tunisian Monocenter Study on 160 Patients.
abstract: OBJECTIVE
  Data regarding cerebral venous thrombosis in North Africa are scarce. This study aims to identify the clinical features, risk factors, outcome, and prognosis of cerebral venous thrombosis in Tunisia.
  
  
  METHODS
  Data of 160 patients with radiologically confirmed cerebral venous thrombosis, hospitalized in Mongi Ben Hmida National Institute of Neurology (Tunis, Tunisia), were retrospectively collected and analyzed.
  
  
  RESULTS
  The mean age was 37.3 years with a female predominance (83.1%). The mode of onset was subacute in most cases (56.2%). Headache was the most common symptom (71.3%), and focal neurologic symptoms were the main clinical presentation (41.8%). The most common sites of thrombosis were the superior sagittal sinus (65%) and the lateral sinus (60.6%). More than 1 sinus was involved in 114 (71.2%) patients. Parenchymal lesions observed in 85 (53.1%) patients did not correlate with cerebral venous thrombosis extent. Major risk factors were obstetric causes (pregnancy and puerperium) found in 46 (38.6% of women aged <50 years) patients, followed by anemia (28.1%) and congenital or acquired thrombophilia (16.2%). Mortality rate was of 6.6%. Good outcome at 6 months (modified Rankin Scale ≤2) was observed in 105 (87.5%)of 120 patients available for follow-up. Predictors of poor outcome were altered consciousness and elevated plasma C-reactive protein levels.
  
  
  CONCLUSIONS
  Clinical and radiologic presentation of cerebral venous thrombosis in Tunisia was quite similar to other parts of the world with, however, a particularly high frequency of obstetric causes. Plasma C-reactive protein level should be considered as a prognostic factor in CVT.
authors: 1 Department of Neurology, Mongi Ben Hmida National Institute of Neurology, Tunis El Manar University, Tunis, Tunisia.
authors: Samia Ben
authors: SB
authors: Sassi
authors: 1 Department of Neurology, Mongi Ben Hmida National Institute of Neurology, Tunis El Manar University, Tunis, Tunisia.
authors: Nahla
authors: N
authors: Touati
authors: 2 Department of Hematology, La Rabta Hospital, Tunis, Tunisia.
authors: Hela
authors: H
authors: Baccouche
authors: 3 Department of Neuroradiology, Mongi Ben Hmida National Institute of Neurology, Tunis, Tunisia.
authors: Cyrine
authors: C
authors: Drissi
authors: 2 Department of Hematology, La Rabta Hospital, Tunis, Tunisia.
authors: Neila Ben
authors: NB
authors: Romdhane
authors: 1 Department of Neurology, Mongi Ben Hmida National Institute of Neurology, Tunis El Manar University, Tunis, Tunisia.
authors: Fayçal
authors: F
authors: Hentati
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D002097:C-Reactive Protein / Q000378:metabolism*; D002648:Child; D005260:Female; D005500:Follow-Up Studies; D006261:Headache / Q000097:blood / Q000175:diagnosis / Q000453:epidemiology; D006801:Humans; D020767:Intracranial Thrombosis / Q000097:blood / Q000175:diagnosis / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular / Q000097:blood / Q000175:diagnosis; D011379:Prognosis; D012307:Risk Factors; D012737:Sex Factors; D054063:Superior Sagittal Sinus; D014416:Tunisia
chemical_list: D002097:C-Reactive Protein
keywords: cerebral venous thrombosis; clinical thrombophilia; vascular disease