title: [Rapid improvement in visual function after high-dose oral corticosteroids in patients with inflammatory optic neuropathy].
abstract: OBJECTIVE
  To study the progression of visual acuity and visual function parameters in patients with optic neuritis (ON) treated with high-dose oral corticosteroid therapy.
  
  
  METHODS
  This retrospective descriptive monocentric study included nine patients with ON treated with orally administered methylprednisolone at 1000 mg per day for three to five days. The follow-up visits were performed on day 4 (D4), day 15 (D15), day 30 (D30) and day 90 (D90) after treatment was begun. The initial examination (D0) and the follow-up visits included a visual acuity (VA) assessment according to the Early Treatment Diabetic Retinopathy Study scale, a contrast sensitivity test and a 30.2 automated visual field (Visual Field Index [VFI]). The overall subjective tolerance of the treatment was assessed by patients on a scale from 0 to 10.
  
  
  RESULTS
  We observed an improvement of all parameters from D4. From D0 to D4, the average VA increased from 40.1 letters to 57.9 letters, the average VFI from 40.9% to 70.3% and the overall average contrast sensitivity from 7.7 dB to 11.3 dB. From D15 to D90, the average VA increased from 77 letters to 80.3 letters, the average VFI from 91.2% to 97.9% and the overall average contrast sensitivity from 15.4 dB to 16.7 dB. Four patients rated tolerance at 10 (excellent), three between 8 and 9, and two at 6.
  
  
  CONCLUSIONS
  We demonstrated rapid improvement of visual function parameters in patients with ON after high-dose oral corticosteroids.
authors: Service d'ophtalmologie, centre hospitalier universitaire de Rennes, 2, rue Henri-le-Guilloux, 35000 Rennes, France.
authors: A
authors: A
authors: Poujade
authors: Service de neurologie, centre hospitalier universitaire de Rennes, 2, rue Henri-le-Guilloux, 35000 Rennes, France.
authors: E
authors: E
authors: Le Page
authors: Service d'ophtalmologie, centre hospitalier universitaire de Rennes, 2, rue Henri-le-Guilloux, 35000 Rennes, France.
authors: D
authors: D
authors: Baudet
authors: Service de neurologie, centre hospitalier universitaire de Rennes, 2, rue Henri-le-Guilloux, 35000 Rennes, France.
authors: G
authors: G
authors: Edan
authors: Service d'ophtalmologie, centre hospitalier universitaire de Rennes, 2, rue Henri-le-Guilloux, 35000 Rennes, France.
authors: B
authors: B
authors: Mortemousque
authors: Service d'ophtalmologie, centre hospitalier universitaire de Rennes, 2, rue Henri-le-Guilloux, 35000 Rennes, France. Electronic address: frederic.mouriaux@chu-rennes.fr.
authors: F
authors: F
authors: Mouriaux
mesh_terms: D000284:Administration, Oral; D000328:Adult; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005260:Female; D005938:Glucocorticoids / Q000008:administration & dosage*; D006801:Humans; D008297:Male; D008775:Methylprednisolone / Q000008:administration & dosage*; D009902:Optic Neuritis / Q000188:drug therapy* / Q000503:physiopathology; D012074:Remission Induction; D012189:Retrospective Studies; D013997:Time Factors; D016896:Treatment Outcome; D014792:Visual Acuity / Q000187:drug effects*; D055815:Young Adult
chemical_list: D005938:Glucocorticoids; D008775:Methylprednisolone
keywords: Acuité visuelle; Champ visuel; Contrast sensitivity; Corticothérapie; Neuropathie optique inflammatoire; Optic neuritis; Sensibilité au contraste; Steroid; Visual acuity; Visual field