title: Oxidative stress equilibrium during obstetric event in normal pregnancy.
abstract: OBJECTIVE
  The aim of this study was to determine malondialdehyde (MDA) concentration as an oxidative stress marker and total antioxidant capacity (TAC) in pregnancy before and after perinatal event.
  
  
  METHODS
  This study was performed on 200 healthy full-term pregnant women admitted to pregnancy resolution in Maternal-Child Hospital of Durango, Mexico. Oxidative stress and TAC were assessed through detection of lipid peroxidation by quantitation of thiobarbituric acid-reactive substances (TBARS) and TAC through ferric reducing ability of the plasma (FRAP).
  
  
  RESULTS
  Our results showed increased levels of MDA after vaginal delivery (VD). TAC was also increased after obstetric event, but it did not differ between VD and caesarean section.
  
  
  CONCLUSIONS
  We demonstrated that MDA concentrations are increased two hours after obstetric event, and this increase correlates with VD. The TAC was increased as a compensatory mechanism during obstetric event. Another important finding is that women receiving analgesia administration in VD, as well as dexamethasone administration in caesarean section, experienced a protector effect that decreased MDA levels.
authors: a Laboratorio de Biología Molecular del Instituto de Investigación Científica de la UJED , Avenida Universidad esq. con Volantín, Zona centro , Durango , Dgo , Mexico.
authors: Jose Manuel
authors: JM
authors: Salas-Pacheco
authors: b Laboratorio Estatal de Salud Pública de Jalisco , Zapopan Jal , Mexico.
authors: Diana Lelidett
authors: DL
authors: Lourenco-Jaramillo
authors: a Laboratorio de Biología Molecular del Instituto de Investigación Científica de la UJED , Avenida Universidad esq. con Volantín, Zona centro , Durango , Dgo , Mexico.
authors: Edna Madai
authors: EM
authors: Mendez-Hernandez
authors: a Laboratorio de Biología Molecular del Instituto de Investigación Científica de la UJED , Avenida Universidad esq. con Volantín, Zona centro , Durango , Dgo , Mexico.
authors: Ada Agustina
authors: AA
authors: Sandoval-Carrillo
authors: c Servicio de Gineco-Obstetricia del Hospital Materno-Infantil de Durango , Durango , Dgo , Mexico.
authors: Yessica Ivonne
authors: YI
authors: Hernandez Rayon
authors: a Laboratorio de Biología Molecular del Instituto de Investigación Científica de la UJED , Avenida Universidad esq. con Volantín, Zona centro , Durango , Dgo , Mexico.
authors: Osmel La
authors: O
authors: Llave-Leon
authors: a Laboratorio de Biología Molecular del Instituto de Investigación Científica de la UJED , Avenida Universidad esq. con Volantín, Zona centro , Durango , Dgo , Mexico.
authors: Marisela
authors: M
authors: Aguilar-Duran
authors: d Coordinación Estatal de Bioingenieria Biomedica, Dirección de Planeación, Sevicios de Salud de Durango , Durango , Dgo , Mexico.
authors: Marcos Alonso
authors: MA
authors: Lopez-Terrones
authors: e Facultad de Ciencias Quimicas de la UJED , Durango , Dgo , Mexico , and.
authors: Marcelo
authors: M
authors: Barraza-Salas
authors: f Laboratorio Clinico del Hospital General 450 , Servicios de Salud de Durango, Durango , Dgo , Mexico.
authors: Fernando
authors: F
authors: Vazquez-Alaniz
mesh_terms: D000328:Adult; D016362:Analgesia, Obstetrical; D000975:Antioxidants / Q000032:analysis; D015415:Biomarkers / Q000097:blood; D002585:Cesarean Section; D036861:Delivery, Obstetric; D003907:Dexamethasone / Q000008:administration & dosage; D005260:Female; D006801:Humans; D015227:Lipid Peroxidation; D008297:Male; D008315:Malondialdehyde / Q000097:blood*; D008800:Mexico; D018384:Oxidative Stress / Q000502:physiology*; D011247:Pregnancy; D011256:Pregnancy Outcome; D017392:Thiobarbituric Acid Reactive Substances / Q000032:analysis; D055815:Young Adult
chemical_list: D000975:Antioxidants; D015415:Biomarkers; D017392:Thiobarbituric Acid Reactive Substances; D008315:Malondialdehyde; D003907:Dexamethasone
keywords: Delivery event; malondialdehyde; oxidative stress; total antioxidant capacity