title: [Etiology analysis of 522 hospitalized cases with Cushing syndrome].
abstract: OBJECTIVE
  To summarize the characteristics of the etiology distribution of Cushing syndrome (CS) patients in Chinese PLA general hospital during the past 20 years.
  
  
  METHODS
  All data of CS patients admitted to Chinese PLA General Hospital between 1995 and 2014 were collected. The sex ratio of patients, visiting age, final diagnosis were retrospectively analyzed.
  
  
  RESULTS
  From January 1995 to December 2014, 522 patients with CS were admitted, of which, 134 (25.67%) were males and 388(74.33%) were females. The overall mean age was (42±13) years old. 46.36% of the cases were adrenocorticotropic hormone (ACTH) dependent, and ACTH independent CS accounted for 53.64%. At the 41-60 age group, the proportion of ACTH independent CS was higher than that of ACTH independent CS.The proportions of ACTH-independent macronodular adrenal hyperplasia (AIMAH), ectopic ACTH syndrome and adrenal cortical carcinoma were higher in male group than in female group. The number of CS patients was gradually increased during the past 20 years. The proportion of ACTH independent CS was increased (from 32.8% to 60.4%). The proportion of ACTH dependent CS was declined (from 67.2% to 39.6%).
  
  
  CONCLUSIONS
  The etiology spectrum of CS has changed. There was significant gender-related, age-related difference of etiology distribution in patients with CS.
authors: Department of Endocrinology, Chinese PLA General Hospital, Key Laboratory of Endocrine and Metabolism of the PLA, Beijing 100853, China.
authors: L L
authors: LL
authors: Li
authors: J T
authors: JT
authors: Dou
authors: G Q
authors: GQ
authors: Yang
authors: W J
authors: WJ
authors: Gu
authors: Z H
authors: ZH
authors: Lü
authors: Y M
authors: YM
authors: Mu
mesh_terms: D000182:ACTH Syndrome, Ectopic; D000324:Adrenocorticotropic Hormone; D000328:Adult; D003480:Cushing Syndrome; D005260:Female; D006801:Humans; D008297:Male; D012189:Retrospective Studies
chemical_list: D000324:Adrenocorticotropic Hormone