title: Supramolecular Assembly of Coronene Derivatives for Drug Delivery.
abstract: Possessing a small size and C3-symmetrical rigid backbone, a coronene derivative was synthesized from β-cyclodextrins and hexa-cata-hexabenzocoronene, and then a water-soluble and biocompatible nanographene/polysaccharide supramolecular assembly was successfully fabricated through noncovalent interactions between adamantly grafted hyaluronic acids and β-cyclodextrin-modified hexa-cata-hexabenzocoronene. Moreover, the ternary supramolecular assembly showed not only a fluorescence imaging ability toward cancer cells but also good anticancer activity and low toxicity.
authors: Department of Chemistry, State Key Laboratory of Elemento-Organic Chemistry, Nankai University , Tianjin 300071, P. R. China.
authors: Jie
authors: J
authors: Yu
authors: Department of Chemistry, State Key Laboratory of Elemento-Organic Chemistry, Nankai University , Tianjin 300071, P. R. China.
authors: Yong
authors: Y
authors: Chen
authors: Department of Chemistry, State Key Laboratory of Elemento-Organic Chemistry, Nankai University , Tianjin 300071, P. R. China.
authors: Yu-Hui
authors: YH
authors: Zhang
authors: Department of Chemistry, State Key Laboratory of Elemento-Organic Chemistry, Nankai University , Tianjin 300071, P. R. China.
authors: Xun
authors: X
authors: Xu
authors: Department of Chemistry, State Key Laboratory of Elemento-Organic Chemistry, Nankai University , Tianjin 300071, P. R. China.|Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Nankai University , Tianjin 300071, P. R. China.
authors: Yu
authors: Y
authors: Liu
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D049109:Cell Proliferation / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D016503:Drug Delivery Systems; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D061986:MCF-7 Cells; D046911:Macromolecular Substances / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D051379:Mice; D041681:NIH 3T3 Cells; D061848:Optical Imaging; D011083:Polycyclic Compounds / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D000970:Antineoplastic Agents; D046911:Macromolecular Substances; D011083:Polycyclic Compounds; C012256:coronene