title: Perturbation of the molecular clockwork in the SCN of non-obese diabetic mice prior to diabetes onset.
abstract: Circadian disruption is associated with the development of diabetes. Non-obese diabetic (NOD) mice show abnormal diurnal profiles in energy balance and locomotor activity suggesting circadian misalignment. Therefore, we analyzed cFos and mPER1 as markers for rhythmic neuronal activity within the suprachiasmatic nucleus (SCN) of wildtype (WT) and non-diabetic (nNOD) as well as acutely diabetic NOD (dNOD) mice. cFos levels show a day/night difference in both WT and nNOD but not in dNOD. mPER1 levels did not show a day/night difference in both nNOD and dNOD. This suggests that disruption of SCN rhythmicity in NOD mice precedes the actual onset of diabetes.
authors: a Institute of Anatomy II, Medical Faculty , Heinrich-Heine University , Düsseldorf , Germany.
authors: Marc
authors: M
authors: Ingenwerth
authors: b Institute for Clinical Diabetology, German Diabetes Center , Düsseldorf.
authors: Anna Lena
authors: AL
authors: Reinbeck
authors: a Institute of Anatomy II, Medical Faculty , Heinrich-Heine University , Düsseldorf , Germany.
authors: Anna
authors: A
authors: Stahr
authors: b Institute for Clinical Diabetology, German Diabetes Center , Düsseldorf.|c German Center for Diabetes Research (DZD), München-Neuherberg , Germany.
authors: Hans-Joachim
authors: HJ
authors: Partke
authors: b Institute for Clinical Diabetology, German Diabetes Center , Düsseldorf.|c German Center for Diabetes Research (DZD), München-Neuherberg , Germany.|d Department of Endocrinology and Diabetology, Medical Faculty , Heinrich-Heine University , Düsseldorf , Germany.
authors: Michael
authors: M
authors: Roden
authors: b Institute for Clinical Diabetology, German Diabetes Center , Düsseldorf.|c German Center for Diabetes Research (DZD), München-Neuherberg , Germany.
authors: Volker
authors: V
authors: Burkart
authors: a Institute of Anatomy II, Medical Faculty , Heinrich-Heine University , Düsseldorf , Germany.
authors: Charlotte
authors: C
authors: von Gall
mesh_terms: D000818:Animals; D056926:CLOCK Proteins / Q000378:metabolism; D018797:Cell Cycle Proteins / Q000378:metabolism; D002940:Circadian Rhythm / Q000502:physiology*; D003921:Diabetes Mellitus, Experimental / Q000378:metabolism*; D008810:Mice, Inbred C57BL; D016688:Mice, Inbred NOD; D008822:Mice, Transgenic; D009687:Nuclear Proteins / Q000378:metabolism; D056950:Period Circadian Proteins / Q000378:metabolism; D013493:Suprachiasmatic Nucleus / Q000378:metabolism*
chemical_list: D018797:Cell Cycle Proteins; D009687:Nuclear Proteins; D056950:Period Circadian Proteins; D056926:CLOCK Proteins
keywords: Clock genes; NOD; diabetes; master clock molecular clockwork; photoentrainment