title: MRI evaluation following partial HIFU therapy for localized prostate cancer: A single-center study.
abstract: OBJECTIVE
  To evaluate the value of MRI for surveillance of primary hemi-HIFU therapy for localized PCa in a single-center.
  
  
  METHODS
  Patients with localized prostate cancer were treated with hemi-HIFU from October 2009 to March 2014. All patients performed MRI before focal therapy, the reader was blinded to the treatment. Oncological failure was defined as positive biopsy or biochemical recurrence (Phoenix).
  
  
  RESULTS
  Twenty-five patients were treated with hemi-HIFU in one center. The median nadir PSA was 1.45±1.4ng/mL. Prostate volume decreased from 45 cc to 25 cc on MRI findings. At 20 months, none of the patients had histological recurrence. Biochemical-free survival rate was 88%. MRI evaluation had a negative predictive value of 100% on the treated area and 81% on the untreated area. PSAd≥0.1ng/mL(2) was a predictive factor for cancer on untreated area (P=0.042).
  
  
  CONCLUSIONS
  MRI control at 6 months is a potentially effective evaluation of treated area after hemi-HIFU and may replace randomized biopsies if PSAd<0.1ng/mL(2) during follow-up.
  
  
  METHODS
  4.
authors: Urology department, Rangueil university hospital, 1, avenue du Pr-Jean-Poulhes, 31059 Toulouse cedex, France. Electronic address: lionel.hoquetis@gmail.com.
authors: L
authors: L
authors: Hoquetis
authors: Urology department, Rangueil university hospital, 1, avenue du Pr-Jean-Poulhes, 31059 Toulouse cedex, France.
authors: B
authors: B
authors: Malavaud
authors: Urology department, Rangueil university hospital, 1, avenue du Pr-Jean-Poulhes, 31059 Toulouse cedex, France.
authors: X
authors: X
authors: Game
authors: Urology department, Rangueil university hospital, 1, avenue du Pr-Jean-Poulhes, 31059 Toulouse cedex, France.
authors: J B
authors: JB
authors: Beauval
authors: Urology department, Rangueil university hospital, 1, avenue du Pr-Jean-Poulhes, 31059 Toulouse cedex, France.
authors: D
authors: D
authors: Portalez
authors: Urology department, Rangueil university hospital, 1, avenue du Pr-Jean-Poulhes, 31059 Toulouse cedex, France.
authors: M
authors: M
authors: Soulie
authors: Urology department, Rangueil university hospital, 1, avenue du Pr-Jean-Poulhes, 31059 Toulouse cedex, France.
authors: P
authors: P
authors: Rischmann
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D011471:Prostatic Neoplasms / Q000473:pathology* / Q000628:therapy*; D036761:Ultrasound, High-Intensity Focused, Transrectal
keywords: Biopsie; Biopsy; Cancer de la prostate; Focal therapy; High-intensity focused ultrasound; Imagerie par résonance magnétique; Magnetic resonance imaging; PSA density; PSA densité; Prostate cancer; Thérapie focale