title: Soluble PD-L1: A biomarker to predict progression of autologous transplantation in patients with multiple myeloma.
abstract: Autologous hematopoietic stem cell transplantation (AuHSCT) is standard in treating eligible multiple myeloma (MM) patients. However, the outcome after treatment is highly variable. We used ELISA to analyze the levels of soluble PD-L1 (suPD-L1) in bone marrow (BM) plasma from 61 patients with MM at 100 days after AuHSCT. Patients were classified into high (H) and normal-to-low (NL) groups depending on their suPD-L1 levels. Among patients who had a very good partial response (VGPR) or better after AuHSCT, those in the H-group had a shorter response period (RpSCT) as well as shorter overall survival (OS) than those in the NL-group. Multivariate analyses confirmed that a high suPD-L1 level and high-risk cytogenetic abnormalities are independent factors for RpSCT. Our data suggest that suPD-L1 in the BM plasma of MM patients who have VGPR or better after AuHSCT could be used as a biomarker to predict outcome.
authors: Department of Internal Medicine, National Taiwan University, Medical College and Hospital, Taipei, Taiwan.
authors: Shang-Yi
authors: SY
authors: Huang
authors: Department of Internal Medicine, National Taiwan University, Medical College and Hospital, Taipei, Taiwan.
authors: Hsiu-Hsia
authors: HH
authors: Lin
authors: Department of Pathology, National Taiwan University, Medical College and Hospital, Taipei, Taiwan.
authors: Chung-Wu
authors: CW
authors: Lin
authors: Tai-Cheng Stem Cell Therapy Center, National Taiwan University, Taipei, Taiwan.
authors: Chi-Cheng
authors: CC
authors: Li
authors: Department of Internal Medicine, National Taiwan University, Medical College and Hospital, Taipei, Taiwan.
authors: Ming
authors: M
authors: Yao
authors: Department of Internal Medicine, National Taiwan University, Medical College and Hospital, Taipei, Taiwan.|Tai-Cheng Stem Cell Therapy Center, National Taiwan University, Taipei, Taiwan.
authors: Jih-Luh
authors: JL
authors: Tang
authors: Department of Internal Medicine, National Taiwan University, Medical College and Hospital, Taipei, Taiwan.
authors: Hsin-An
authors: HA
authors: Hou
authors: Department of Internal Medicine, National Taiwan University, Medical College and Hospital, Taipei, Taiwan.
authors: Woei
authors: W
authors: Tsay
authors: Department of Internal Medicine, National Taiwan University, Medical College and Hospital, Taipei, Taiwan.
authors: Sheng-Je
authors: SJ
authors: Chou
authors: Department of Internal Medicine, National Taiwan University, Medical College and Hospital, Taipei, Taiwan.
authors: Chieh-Lung
authors: CL
authors: Cheng
authors: Department of Internal Medicine, National Taiwan University, Medical College and Hospital, Taipei, Taiwan.
authors: Hwei-Fang
authors: HF
authors: Tien
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D060890:B7-H1 Antigen / Q000097:blood*; D014408:Biomarkers, Tumor / Q000097:blood*; D001853:Bone Marrow / Q000378:metabolism; D018414:CD8-Positive T-Lymphocytes / Q000166:cytology; D018450:Disease Progression; D018572:Disease-Free Survival; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000097:blood* / Q000628:therapy*; D015999:Multivariate Analysis; D010949:Plasma / Q000378:metabolism; D011379:Prognosis; D016016:Proportional Hazards Models; D012372:ROC Curve; D014182:Transplantation, Autologous; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D060890:B7-H1 Antigen; D014408:Biomarkers, Tumor; C423236:CD274 protein, human
keywords: autologous transplantation; bone marrow plasma; multiple myeloma; prognosis; soluble PD-L1