title: Rapid Synthesis of Aryl Fluorides in Continuous Flow through the Balz-Schiemann Reaction.
abstract: The Balz-Schiemann reaction remains a highly utilized means for preparing aryl fluorides from anilines. However, the limitations associated with handling aryl diazonium salts often hinder both the substrate scope and scalability of this reaction. To address this, a new continuous flow protocol was developed that eliminates the need to isolate the aryl diazonium salts. The new process has enabled the fluorination of an array of aryl and heteroaryl amines.
authors: Department of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA, 02139, USA.
authors: Nathaniel H
authors: NH
authors: Park
authors: Department of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA, 02139, USA.
authors: Timothy J
authors: TJ
authors: Senter
authors: Department of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA, 02139, USA. sbuchwal@mit.edu.
authors: Stephen L
authors: SL
authors: Buchwald
keywords: Balz-Schiemann reaction; aryl diazonium salts; continuous flow process; fluorination; synthetic methods