title: Expression of microRNA-370 in human breast cancer compare with normal samples.
abstract: BACKGROUND
  Breast cancer is the second leading cause of deaths from cancer in the woman. MicroRNAs (miRNAs) are endogenous noncoding RNAs that are known critical player in carcinogenesis. The role of miR-370 in malignancies remains controversial because of its levels varying in different cancers according to its targets while the role of miR-370 in breast cancer has not been addressed so far. The aim of this study was to identify the expression pattern of miR-370 in human breast cancer tissue compared to adjacent healthy tissue.
  
  
  METHODS
  Twenty-two fresh frozen tissues (normal and malignant) from patients with breast cancer were examined for miR-370 by quantitative real-time polymerase chain reaction method at 2013.
  
  
  RESULTS
  We observed up-regulation (six-fold higher) of miR-370 in breast cancer tissue compared with normal adjacent tissue. Tumor samples in stage III, invasive ductal type, larger tumor size, human epidermal growth-factor receptor 2+, estrogen receptor/progesterone receptor-, P53 - status showed significantly increased expression in miR-370.
  
  
  CONCLUSIONS
  Together, miR-370 may acts as an onco-miRNA, and it may have a novel role in breast cancer. Detection of miR-370 and its targets could be helpful as a diagnostic biomarker and therapeutic target.
authors: Department of Immunology, Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
authors: Halimeh
authors: H
authors: Mollainezhad
authors: Department of Immunology, Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran; Applied Physiology Research Centre, Isfahan University of Medical Sciences, Isfahan, Iran.
authors: Nahid
authors: N
authors: Eskandari
authors: Department of Immunology, Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
authors: Abbasali
authors: A
authors: Pourazar
authors: Genetics and Molecular Biology, Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
authors: Mansoor
authors: M
authors: Salehi
authors: Department of Immunology, Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
authors: Alireza
authors: A
authors: Andalib
keywords: Biomarker; breast cancer; microRNAs