title: Expression of Molecular Markers of Angiogenesis, Lymphangiogenesis, and Proliferation Depending on the Stage of Skin Melanoma.
abstract: The expression of molecular markers characterizing activity of the tumor process and metastases (proliferation marker Ki-67, angiogenesis marker CD34, and lymphangiogenesis markers podoplanin and LYVE-1) was assessed by immunohictochemical method in the primary tumor specimens collected during surgery for cutaneous melanoma (40 patients). Proliferative activity of the tumor tissue and volume density of peritumoral blood and lymph vessels increased with increasing tumor malignancy, which could indicate the risk of metastases.
authors: Institute of Clinical and Experimental Lymphology, Novosibirsk, Russia. n_bgatova@ngs.ru.
authors: N P
authors: NP
authors: Bgatova
authors: Novosibirsk Regional Clinical Oncological Center, Novosibirsk, Russia.
authors: A I
authors: AI
authors: Lomakin
authors: Novosibirsk Regional Clinical Oncological Center, Novosibirsk, Russia.
authors: S A
authors: SA
authors: Fursov
authors: Novosibirsk Regional Clinical Oncological Center, Novosibirsk, Russia.
authors: I V
authors: IV
authors: Kachesov
authors: Novosibirsk Regional Clinical Oncological Center, Novosibirsk, Russia.
authors: S A
authors: SA
authors: Chepko
authors: Novosibirsk Regional Clinical Oncological Center, Novosibirsk, Russia.
authors: N B
authors: NB
authors: Isakova
authors: Institute of Clinical and Experimental Lymphology, Novosibirsk, Russia.
authors: Yu I
authors: YI
authors: Borodin
authors: Novosibirsk Regional Clinical Oncological Center, Novosibirsk, Russia.
authors: V E
authors: VE
authors: Voytsitsky
authors: Institute of Clinical and Experimental Lymphology, Novosibirsk, Russia.
authors: V I
authors: VI
authors: Konenkov
mesh_terms: D000328:Adult; D018952:Antigens, CD34 / Q000378:metabolism; D049109:Cell Proliferation / Q000502:physiology; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D066298:In Vitro Techniques; D019394:Ki-67 Antigen / Q000378:metabolism; D042583:Lymphangiogenesis / Q000502:physiology*; D008297:Male; D008545:Melanoma / Q000378:metabolism*; D008562:Membrane Glycoproteins / Q000378:metabolism; D009389:Neovascularization, Pathologic / Q000378:metabolism*; D012878:Skin Neoplasms / Q000378:metabolism*; D033921:Vesicular Transport Proteins / Q000378:metabolism; D000096142:Cutaneous Malignant Melanoma; D000098853:Podoplanin
chemical_list: D018952:Antigens, CD34; D019394:Ki-67 Antigen; D008562:Membrane Glycoproteins; D033921:Vesicular Transport Proteins; C119248:LYVE1 protein, human; C117468:PDPN protein, human; D000098853:Podoplanin
keywords: angiogenesis; cutaneous melanoma; lymphangiogenesis; proliferation