title: Evaluation of the relation between anemia and periodontitis by estimation of blood parameters: A cross-sectional study.
abstract: BACKGROUND
  Anemia of chronic disease is defined as anemia occurring in chronic infections, inflammatory conditions, or neoplastic disorders which are not due to marrow deficiencies or other diseases, and occurring despite the presence of adequate iron stores and vitamins.
  
  
  OBJECTIVE
  To evaluate the relation between anemia and periodontitis by estimation of blood parameters and to assess whether periodontitis like other inflammatory conditions can lead to anemia. It is a randomized controlled clinical trial.
  
  
  METHODS
  A total of 50 healthy controls, 50 chronic generalized gingivitis, and 50 chronic generalized periodontitis patients were selected. Hemoglobin levels (Hb), erythrocyte count red blood cell, erythrocyte sedimentation rate (ESR), mean corpuscular volu e (MCV), mean corpuscular Hb (MCH) and MCH concentration (MCHC), gingival index, plaque index, probing pocket depth, and clinical attachment level were recorded. Intergroup comparison of blood parameters is by one-way ANOVA. Intergroup pair wise comparison of the three groups is by Newman-Keuls multiple post-hoc procedures. Karl Pearsons's correlation coefficient method is used for correlation between different parameters for three groups.
  
  
  RESULTS
  The results revealed a decrease in Hb and erythrocyte counts and increase in white blood corpuscles counts in chronic generalized periodontitis when compared to healthy controls and chronic generalized gingivitis group. There was no statistically significant difference in MCV, MCH, MCHC, and ESR among the groups.
  
  
  CONCLUSIONS
  The treatment of periodontitis can lead to an improvement in hematocrit and other related blood parameters in chronic generalized periodontitis patients with anemia. This provides evidence that periodontitis like other chronic diseases may also cause anemia.
authors: Department of Periodontics and Implantology, Dr. Sudha and Nageswara Rao Siddhartha Institute of Dental Sciences, Chinnaoutpalli, Gannavaram Mandal, Krishna, Andhra Pradesh, India.
authors: Venkata Naga Sri Harsha
authors: VN
authors: Anumolu
authors: Department of Periodontics and Implantology, Dr. Sudha and Nageswara Rao Siddhartha Institute of Dental Sciences, Chinnaoutpalli, Gannavaram Mandal, Krishna, Andhra Pradesh, India.
authors: Adusumilli
authors: A
authors: Srikanth
authors: Department of Periodontics and Implantology, Dr. Sudha and Nageswara Rao Siddhartha Institute of Dental Sciences, Chinnaoutpalli, Gannavaram Mandal, Krishna, Andhra Pradesh, India.
authors: Kusumalatha
authors: K
authors: Paidi
keywords: Anemia; anemia of chronic disease; hemoglobin; periodontitis