title: Effect of Linagliptin on Structural Changes in the Kidney in Experimental Type 2 Diabetes Mellitus.
abstract: Effect of the dipeptidyl peptidase-4 inhibitor linagliptin on structural manifestations of diabetic nephropathy was studied in BKS.Cg-Dock7m+/+Leprdb/J mice (experimental model of type 2 diabetes mellitus). Linagliptin (10 mg/kg per day) or vehicle was administered by gavage over 8 weeks. Mesangial expansion, thickening of the basement membrane in glomerular capillaries and proximal tubules, and retraction of cytopodia were less pronounced in mice receiving linagliptin. The protective effect of linagliptin on the kidney structure was not associated with its hypoglycemic action.
authors: Research Institute of Clinical and Experimental Lymphology, Novosibirsk, Russia. inabrite@yandex.ru.
authors: Yu S
authors: YS
authors: Gavrilova
authors: Research Institute of Clinical and Experimental Lymphology, Novosibirsk, Russia.
authors: N P
authors: NP
authors: Bgatova
authors: Research Institute of Clinical and Experimental Lymphology, Novosibirsk, Russia.
authors: V V
authors: VV
authors: Klimontov
authors: Research Institute of Clinical and Experimental Lymphology, Novosibirsk, Russia.
authors: I Yu
authors: IY
authors: Ischenko
authors: Research Institute of Clinical and Experimental Lymphology, Novosibirsk, Russia.
authors: S V
authors: SV
authors: Michurina
authors: Research Institute of Clinical and Experimental Lymphology, Novosibirsk, Russia.
authors: N E
authors: NE
authors: Myakina
authors: Federal Research Center Institute of Cytology and Genetics of Siberian Branch of Russian Academy of Sciences, Novosibirsk, Russia.
authors: E L
authors: EL
authors: Zavyalov
mesh_terms: D000818:Animals; D001485:Basement Membrane / Q000187:drug effects / Q000473:pathology; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy* / Q000473:pathology; D003928:Diabetic Nephropathies / Q000188:drug therapy / Q000473:pathology; D007004:Hypoglycemic Agents / Q000627:therapeutic use; D007668:Kidney / Q000187:drug effects* / Q000473:pathology; D007678:Kidney Glomerulus / Q000187:drug effects / Q000473:pathology; D000069476:Linagliptin / Q000627:therapeutic use*; D008297:Male; D051379:Mice
chemical_list: D007004:Hypoglycemic Agents; D000069476:Linagliptin
keywords: diabetic nephropathy; linagliptin; type 2 diabetes mellitus