title: Increased homocysteine plasma level is associated with shortened prothrombin time in HIV-infected patients.
abstract: To find factors associated with increased homocysteine plasma level in HIV-infected patients.
  
  
  
  Cross-sectional study, carried out as a supplementary task to the standard care of HIV-infected patients. The possible association of increased homocysteine plasma level with blood analyses results was assessed with a multiple linear regression analysis, using the automatic linear modeling available in SPSS version 22.
  
  
  
  A total of 145 patients were included. Creatinine was higher than normal in 7 patients (5%), prothrombin time was shortened in 36 patients (25%), and a monoclonal gammopathy was detected in 2 patients (1%). In the regression analysis, an association was found between high homocysteine plasma level and the following variables: low prothrombin time (β coefficient -0.286, confidence interval -1.1854 to -0.754, p < 0.001), high creatinine (coefficient 9.926, confidence interval 6.351-15.246, p < 0.001), low folic acid (coefficient -0.331, confidence interval -0-483 to -0.187, p < 0.001), and low vitamin B12 (coefficient -0.007, confidence interval -0.01 to -0.001, p = 0.005).
  
  
  
  An association was found between increased homocysteine plasma level and shortened prothrombin time.
authors: a Medicine Department , Hospital General , Castellon , Spain.
authors: Bernardino
authors: B
authors: Roca
authors: b Ophthalmology Department , Hospital Provincial , Castellon , Spain.
authors: Manuel
authors: M
authors: Roca
authors: a Medicine Department , Hospital General , Castellon , Spain.
authors: Guillermo
authors: G
authors: Girones
mesh_terms: D000328:Adult; D000368:Aged; D023241:Antiretroviral Therapy, Highly Active; D015415:Biomarkers; D001777:Blood Coagulation; D018791:CD4 Lymphocyte Count; D003430:Cross-Sectional Studies; D005260:Female; D005500:Follow-Up Studies; D015658:HIV Infections / Q000097:blood* / Q000175:diagnosis / Q000188:drug therapy / Q000821:virology; D006710:Homocysteine / Q000097:blood*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010045:Outpatients; D011517:Prothrombin Time; D012015:Reference Standards; D012044:Regression Analysis; D013030:Spain; D019562:Viral Load; D055815:Young Adult
chemical_list: D015415:Biomarkers; D006710:Homocysteine
keywords: HIV-infection; Prothrombin time; homocysteine