title: Prevalence and Associated Factors of Insulin Resistance in Adults from Maracaibo City, Venezuela.
abstract: Background and Aim. Insulin resistance (IR) is a prominent pathophysiologic component in a myriad of metabolic disorders, including obesity, prediabetes, and type 2 diabetes mellitus, which are common in our locality. The objective of this study was to determine the prevalence of IR and factors associated with this condition in an adult population from Maracaibo city, Venezuela. Methodology. A cross-sectional, descriptive study with multistaged randomized sampling was carried out in 2026 adults. IR was defined as HOMA2-IR ≥ 2. A multiple logistic regression model was constructed in order to evaluate factors associated with IR. Results. The prevalence of IR was 46.5% (n = 943), with 46.7% (n = 450) in the general population, 46.4% (n = 493) in females, and 47.90% (n = 970) in males (p = 0.895). IR prevalence tended to increase with age and was significantly greater in subjects aged ≥30 years (χ (2) = 16.726; p = 2.33 × 10(-4)). Employment, alcohol consumption, obesity, high triacylglycerides, low HDL-C, and dysglycemia were associated with greater odds of IR, whereas a high level of physical activity appeared to be weak protective factor against IR. Conclusions. The prevalence of IR is elevated in our locality. The main determinants of this condition appear to be the presence of obesity, high triacylglycerides, low HDL-C, dysglycemia, and alcohol intake.
authors: Endocrine and Metabolic Diseases Research Center, School of Medicine, University of Zulia, Maracaibo 4004, Venezuela.
authors: Valmore
authors: 0000-0003-1880-8887
authors: V
authors: Bermudez
authors: Endocrine and Metabolic Diseases Research Center, School of Medicine, University of Zulia, Maracaibo 4004, Venezuela.
authors: Juan
authors: 0000-0003-4211-528X
authors: J
authors: Salazar
authors: Endocrine and Metabolic Diseases Research Center, School of Medicine, University of Zulia, Maracaibo 4004, Venezuela.
authors: María Sofía
authors: 0000-0002-3419-0960
authors: MS
authors: Martínez
authors: Endocrine and Metabolic Diseases Research Center, School of Medicine, University of Zulia, Maracaibo 4004, Venezuela.
authors: Mervin
authors: 0000-0001-8511-0230
authors: M
authors: Chávez-Castillo
authors: Endocrine and Metabolic Diseases Research Center, School of Medicine, University of Zulia, Maracaibo 4004, Venezuela.
authors: Luis Carlos
authors: 0000-0002-9325-6376
authors: LC
authors: Olivar
authors: Endocrine and Metabolic Diseases Research Center, School of Medicine, University of Zulia, Maracaibo 4004, Venezuela.
authors: María José
authors: 0000-0002-9569-2796
authors: MJ
authors: Calvo
authors: Endocrine and Metabolic Diseases Research Center, School of Medicine, University of Zulia, Maracaibo 4004, Venezuela.
authors: Jim
authors: J
authors: Palmar
authors: Endocrine and Metabolic Diseases Research Center, School of Medicine, University of Zulia, Maracaibo 4004, Venezuela.
authors: Jordan
authors: 0000-0003-4059-7086
authors: J
authors: Bautista
authors: Endocrine and Metabolic Diseases Research Center, School of Medicine, University of Zulia, Maracaibo 4004, Venezuela.
authors: Eduardo
authors: 0000-0002-1038-9238
authors: E
authors: Ramos
authors: Endocrine and Metabolic Diseases Research Center, School of Medicine, University of Zulia, Maracaibo 4004, Venezuela.
authors: Mayela
authors: M
authors: Cabrera
authors: Morphologic Sciences Department and Pediatric Surgery Department, School of Medicine, University of Zulia, Maracaibo 4004, Venezuela.
authors: Freddy
authors: 0000-0003-0427-0465
authors: F
authors: Pachano
authors: Endocrine and Metabolic Diseases Research Center, School of Medicine, University of Zulia, Maracaibo 4004, Venezuela.
authors: Joselyn
authors: 0000-0003-4994-075X
authors: J
authors: Rojas