title: IgG4 related sclerosing sialadenitis- a retrospective analysis.
abstract: BACKGROUND
  IgG4 related disease rarely affects the salivary glands and clinically is often confused with salivary gland malignancy.
  
  
  METHODS
  This is a retrospective study comprising 137 cases of chronic sialadenitis diagnosed in a histopathology department over 4 years. The morphology was assessed by reviewing the histology slides and the incidence of IgG4 related sclerosing sialadenitis was calculated. IgG and IgG4 immunohistochemistry was performed and mean IgG4 count/hpf and IgG4/IgG ratio were determined. Clinical findings were obtained from medical records.
  
  
  RESULTS
  Of the 137 cases reviewed, 3 cases showed diagnostic histological features of IgG4 related sialadenitis, these being: a prominent lymphoplasmacytic infiltrate, lobular fibrosis, acinar atrophy, obliterative phlebitis and mean IgG4 count of 86/hpf with mean IgG4/IgG ratio 65%. No further disease was documented at follow-up which ranged from 24 to 36 months.
  
  
  CONCLUSIONS
  The incidence of IgG4 related sialadenitis in the present study is 2%, indicating that it is a rare condition. Since there is no non-invasive diagnostic modality, either core biopsy or surgical excision is required for definitive histological diagnosis.
authors: Royal Surrey County Hospital, Department of Histopathology, Egerton Road, Guildford GU2 7XX, United Kingdom. izhardrster@gmail.com.
authors: T N K W
authors: TN
authors: Gunasekara
authors: S
authors: S
authors: Di Palma
authors: I N
authors: IN
authors: Bagwan
mesh_terms: D000368:Aged; D006801:Humans; D007154:Immune System Diseases / Q000453:epidemiology / Q000276:immunology* / Q000473:pathology; D007074:Immunoglobulin G; D007150:Immunohistochemistry; D015994:Incidence; D008297:Male; D012189:Retrospective Studies; D012793:Sialadenitis / Q000453:epidemiology / Q000276:immunology* / Q000473:pathology
chemical_list: D007074:Immunoglobulin G