title: Antiproliferative Effects of Mesenchymal Stem Cells and Epithelial Cells on Lymphocytes.
abstract: We analyzed the interactions between peripheral blood lymphocytes from heterologous donors with mesenchymal stem cells obtained from the tooth pulp and trophoblast. In mixed cultures, proliferation of both lymphocytes and mesenchymal stem cells was suppressed. Similar suppressive effects were observed in lymphocyte cultures mixed with epithelial cells (hepatocytes HeG2 and renal epithelial cells HEK293). This suppression can be determined by impairment of normal adhesion contacts between cells of different origin.
authors: M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia. esvir@mx.ibch.ru.
authors: E V
authors: EV
authors: Svirshchevskaya
authors: V. I. Kulakov Research Center for Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation, Moscow, Russia.
authors: R A
authors: RA
authors: Poltavtseva
authors: V. I. Kulakov Research Center for Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation, Moscow, Russia.
authors: I P
authors: IP
authors: Beletskii
authors: Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino, Moscow region, Russia.
authors: I I
authors: II
authors: Selezneva
authors: M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia.
authors: G T
authors: GT
authors: Sukhikh
mesh_terms: D002450:Cell Communication / Q000502:physiology; D049109:Cell Proliferation / Q000502:physiology; D002478:Cells, Cultured; D018920:Coculture Techniques; D003782:Dental Pulp / Q000166:cytology; D004847:Epithelial Cells / Q000166:cytology* / Q000502:physiology; D005260:Female; D057809:HEK293 Cells; D056945:Hep G2 Cells; D006801:Humans; D008214:Lymphocytes / Q000166:cytology* / Q000502:physiology; D059630:Mesenchymal Stem Cells / Q000166:cytology* / Q000502:physiology; D011247:Pregnancy; D014327:Trophoblasts / Q000166:cytology
keywords: mesenchymal stem cells; peripheral blood lymphocytes; proliferation