title: Multilayered regulations of RIG-I in the anti-viral signaling pathway.
abstract: RIG-I is a cytosolic receptor recognizing virus-specific RNA structures and initiates an antiviral signaling that induces the production of interferons and proinflammatory cytokines. Because inappropriate RIG-I signaling affects either viral clearance or immune toxicity, multiple regulations of RIG-I have been investigated since its discovery as the viral RNA detector. In this review, we describe the recent progress in research on the regulation of RIG-I activity or abundance. Specifically, we focus on the mechanism that modulates RIG-I-dependent antiviral response through post-translational modifications of or protein-protein interactions with RIG-I.
authors: Department of Life Sciences, Pohang University of Science and Technology, Pohang, 37673, Republic of Korea. bekya@postech.ac.kr.
authors: Nari
authors: N
authors: Kim
authors: Department of Life Sciences, Pohang University of Science and Technology, Pohang, 37673, Republic of Korea.
authors: Hesung
authors: H
authors: Now
authors: Department of Life Sciences, Pohang University of Science and Technology, Pohang, 37673, Republic of Korea.
authors: Nhung T H
authors: NTH
authors: Nguyen
authors: Department of Life Sciences, Pohang University of Science and Technology, Pohang, 37673, Republic of Korea. jyoo@postech.ac.kr.
authors: Joo-Yeon
authors: JY
authors: Yoo
mesh_terms: D000818:Animals; D000071457:DEAD Box Protein 58 / Q000235:genetics* / Q000276:immunology*; D005786:Gene Expression Regulation; D054884:Host-Pathogen Interactions; D006801:Humans; D011485:Protein Binding; D011971:Receptors, Immunologic; D015398:Signal Transduction; D014777:Virus Diseases / Q000235:genetics / Q000276:immunology* / Q000821:virology; D014780:Viruses / Q000235:genetics / Q000276:immunology*
chemical_list: D011971:Receptors, Immunologic; C452820:RIGI protein, human; D000071457:DEAD Box Protein 58
keywords: RIG-I; RNA virus; antiviral signaling; post-translational modification; protein-protein interaction