title: Compensatory variances of drug-induced hepatitis B virus YMDD mutations.
abstract: Although the drug-induced mutations of HBV have been ever documented, the evolutionary mechanism is still obscure. To deeply reveal molecular characters of HBV evolution under the special condition, here we made a comprehensive investigation of the molecular variation of the 3432 wild-type sequences and 439 YMDD variants from HBV genotype A, B, C and D, and evaluated the co-variant patterns and the frequency distribution in the different YMDD mutation types and genotypes, by using the naïve Bayes classification algorithm and the complete induction method based on the comparative sequence analysis. The data showed different compensatory changes followed by the rtM204I/V. Although occurrence of the YMDD mutation itself was not related to the HBV genotypes, the subsequence co-variant patterns were related to the YMDD variant types and HBV genotypes. From the hierarchy view, we clarified that historical mutations, drug-induced mutation and compensatory variances, and displayed an inter-conditioned relationship of amino acid variances during multiple evolutionary processes. This study extends the understanding of the polymorphism and fitness of viral protein.
authors: Department of Infectious Diseases, No. 324 Hospital of PLA, Chongqing, 400020 China.
authors: Ying
authors: Y
authors: Cai
authors: Medical Research Center, Southwest Hospital, Third Military Medical University, Chongqing, 400038 China.
authors: Ning
authors: N
authors: Wang
authors: Department of Infectious Diseases, No. 324 Hospital of PLA, Chongqing, 400020 China.
authors: Xiaomei
authors: X
authors: Wu
authors: Medical Research Center, Southwest Hospital, Third Military Medical University, Chongqing, 400038 China.
authors: Kai
authors: K
authors: Zheng
authors: Medical Research Center, Southwest Hospital, Third Military Medical University, Chongqing, 400038 China ; Department of Microbiology, Third Military Medical University, Chongqing, 400038 China.
authors: Yan
authors: Y
authors: Li
keywords: Covariance; Drug resistance; Evolution; HBV; Mutation; YMDD