title: [Chronic neutrophilic leukemia complicated with multiple myeloma: two cases report and literature review].
abstract: OBJECTIVE
  To explored the diagnosis and treatment of chronic neutrophilic leukemia (CNL) complicated with multiple myeloma (MM).
  
  
  METHODS
  The clinical features and molecular biological characteristics of 2 patients with CNL complicated with MM were summarized, and the diagnosis and treatment of the patients were retrospectively reviewed.
  
  
  RESULTS
  The diagnosis of CNL complicated with MM was established in 2 cases. Case 1 had CSF3R mutation (P733T), but CSF3R-exon 14 mutation and SETBP1 mutation were all negative. The neutrophil count returned to normal when MM was successfully treated in case 1. When the patient relapsed, neutrophil count increased again.
  
  
  CONCLUSIONS
  Coexistence of CNL and MM is rare. CSF3R is a very important molecular marker for CNL. To the best of our knowledge, it's the first time to report the coexistence of CNL and MM carried CSF3R mutation (P733T). Chemotherapy regimens for MM may be effective in the treatment of CNL complicated with MM.
authors: Institute of Hematology & Blood Diseases Hospital, CAMS & PUMC, Tianjin 300020, China.
authors: B
authors: B
authors: Jiang
authors: J Y
authors: JY
authors: Qi
authors: Q H
authors: QH
authors: Li
authors: Y
authors: Y
authors: Xu
authors: M Y
authors: MY
authors: Sun
authors: W W
authors: WW
authors: Zheng
authors: F
authors: F
authors: Chen
authors: L G
authors: LG
authors: Qiu
mesh_terms: D015415:Biomarkers; D002352:Carrier Proteins; D005091:Exons; D006801:Humans; D015467:Leukemia, Neutrophilic, Chronic / Q000150:complications* / Q000175:diagnosis* / Q000628:therapy*; D009101:Multiple Myeloma / Q000150:complications*; D009154:Mutation; D009687:Nuclear Proteins; D016184:Receptors, Colony-Stimulating Factor; D015398:Signal Transduction
chemical_list: D015415:Biomarkers; D002352:Carrier Proteins; D009687:Nuclear Proteins; D016184:Receptors, Colony-Stimulating Factor; C425066:SETBP1 protein, human