title: Clinical application of DEX/CRH test and multi-channel NIRS in patients with depression.
abstract: BACKGROUND
  To reduce the number of patients with depression, biomarkers for clarifying psychiatric disorders are warranted. Numerous candidates have been proposed; however, near-infrared spectroscopy (NIRS) with multi-channel probes and a dexamethasone/corticotropin-releasing hormone (DEX/CRH) test are still surviving for practical demand. Thirty-one outpatients with depressed moods were analyzed using both biological tests.
  
  
  RESULTS
  The non-suppressors, as indicated by the DEX/CRH test, exhibited a high severity on the Hamilton Depression Scale and severe anxiety on the State Trait Anxiety Scale. In addition, a unique response was identified via NIRS in the same group suggested by the DEX/CRH assessment.
  
  
  CONCLUSIONS
  The results obtained from these biological tests did not fit well with the category defined by operative diagnostic criteria, such as the Diagnostic and Statistical Manual of Mental Disorders or The International Classification of Diseases. Thus, it is critical that the utility evaluations of candidate biomarkers not be assessed by comparisons with the categorized criteria for a specific psychiatric disorder. Trial registration UMIN000013214, Registered 21 February 2014.
authors: Department of Neuropsychiatry, Osaka Medical College, 2-7, Daigaku-Cho, Takatsuk, Osaka, 569-8686, Japan.
authors: Shinya
authors: S
authors: Kinoshita
authors: Department of Neuropsychiatry, Osaka Medical College, 2-7, Daigaku-Cho, Takatsuk, Osaka, 569-8686, Japan. psy052@osaka-med.ac.jp.
authors: Tetsufumi
authors: T
authors: Kanazawa
authors: Department of Neuropsychiatry, Osaka Medical College, 2-7, Daigaku-Cho, Takatsuk, Osaka, 569-8686, Japan.|Department of Psychiatry, Shin-Abuyama Hospital, Osaka Institute of Clinical Psychiatry, Osaka, Japan.
authors: Hiroki
authors: H
authors: Kikuyama
authors: Department of Neuropsychiatry, Osaka Medical College, 2-7, Daigaku-Cho, Takatsuk, Osaka, 569-8686, Japan.
authors: Hiroshi
authors: H
authors: Yoneda
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000032:analysis*; D003346:Corticotropin-Releasing Hormone / Q000032:analysis / Q000097:blood; D003863:Depression / Q000175:diagnosis* / Q000235:genetics / Q000378:metabolism; D003865:Major Depressive Disorder / Q000175:diagnosis; D003907:Dexamethasone / Q000032:analysis / Q000097:blood; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000032:analysis; D007030:Hypothalamo-Hypophyseal System; D008297:Male; D008875:Middle Aged; D010913:Pituitary-Adrenal System; D011569:Psychiatric Status Rating Scales; D019265:Spectroscopy, Near-Infrared / Q000379:methods*
chemical_list: D015415:Biomarkers; D003907:Dexamethasone; D003346:Corticotropin-Releasing Hormone; D006854:Hydrocortisone
keywords: Biomarker; DEX/CRH test; Depression; HAMD; NIRS