title: De Novo Designed Imaging Agents Based on Lanthanide Peptides Complexes.
abstract: Herein are discussed a selection of lanthanide peptide/protein complexes in view of their potential applications as imaging agents, both in terms of luminescence detection and magnetic resonance imaging. Though this chapter covers a range of different peptides and protein, if focuses specifically on the opportunities afforded by the de novo design of coiled coils, miniature protein scaffolds, and the development on lanthanide-binding sites into these architectures. The requirements for lanthanide coordination and the challenges that need to be addressed when preparing lanthanide peptides with a view to their potential adoption as clinical imaging applications, will be highlighted.
authors: School of Chemistry, University of Birmingham, Edgbaston, United Kingdom. Electronic address: a.f.a.peacock@bham.ac.uk.
authors: A F A
authors: AF
authors: Peacock
mesh_terms: D000595:Amino Acid Sequence / Q000235:genetics; D001665:Binding Sites; D003287:Contrast Media / Q000138:chemical synthesis / Q000737:chemistry*; D028581:Lanthanoid Series Elements / Q000138:chemical synthesis / Q000737:chemistry*; D049449:Luminescence; D008279:Magnetic Resonance Imaging; D010455:Peptides / Q000138:chemical synthesis / Q000737:chemistry*; D011506:Proteins / Q000138:chemical synthesis / Q000737:chemistry*
chemical_list: D003287:Contrast Media; D028581:Lanthanoid Series Elements; D010455:Peptides; D011506:Proteins
keywords: Coiled coils; Coordination chemistry; De novo design; Gadolinium; Imaging; Lanthanide; Luminescence; MRI; Peptide