title: Liposarcoma: Multimodality Management and Future Targeted Therapies.
abstract: There are 3 biologic groups of liposarcoma: well-differentiated and dedifferentiated liposarcoma, myxoid/round cell liposarcoma, and pleomorphic liposarcoma. In all 3 groups, complete surgical resection is central in treatment aimed at cure and is based on grade. Radiation can reduce risk of local recurrence in high-grade lesions or minimize surgical morbidity in the myxoid/round cell liposarcoma group. The groups differ in chemosensitivity, so adjuvant chemotherapy is selectively used in histologies with metastatic potential but not in the resistant subtype dedifferentiated liposarcoma. Improved understanding of the genetic aberrations that lead to liposarcoma initiation is allowing for the rapid development of targeted therapies for liposarcoma.
authors: Sarcoma Disease Management Team, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA; Gastric and Mixed Tumor Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, H1220, New York, NY 10065, USA; Department of Surgery, Weill Cornell Medical College, 1300 York Avenue, New York, NY, USA. Electronic address: cragoa@mskcc.org.
authors: Aimee M
authors: AM
authors: Crago
authors: Sarcoma Disease Management Team, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA; Sarcoma Oncology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, 300 East 66th Street, New York, NY 10065, USA; Department of Medicine, Weill Cornell Medical College, 1300 York Avenue, New York, NY 10065, USA.
authors: Mark A
authors: MA
authors: Dickson
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D006801:Humans; D008080:Liposarcoma / Q000145:classification* / Q000473:pathology / Q000628:therapy*; D018208:Liposarcoma, Myxoid / Q000473:pathology / Q000628:therapy*; D058990:Molecular Targeted Therapy; D064847:Multimodal Imaging; D060787:Neoplasm Grading; D009364:Neoplasm Recurrence, Local; D057285:Precision Medicine
keywords: CDK4; FUS-CHOP; Liposarcoma; MDM2; Myxoid liposarcoma; Pleomorphic liposarcoma; Sarcoma; Trabectedin