title: [Male contraception - the current state of knowledge].
abstract: Contraception is important from a health, psychological and socioeconomic point of view. Due to the fact that male-based contraceptive methods are mostly represented by condoms and vasectomy, researchers are working on the new solutions, which could let the men be more involved in a conscious family planning. In this review we will present the current state of knowledge on this subject. There is a lot going on in the field of hormonal contraception. Studies including testosterone, progestins, synthetic androgens and other derivatives are on a different stages of clinical trials and mostly demonstrate high efficacy rates. Recent discovers of Izumo and Juno proteins, essential for the fertilization process, give hope for an easily reversible, non-hormonal method. Researchers are also trying to interfere with the process of spermatogenesis using BRDT inhibitor - JQ1, or neutralize the sperm by injecting styrene maleic anhydride (SMA) into the lumen of the vas deferens. The other studies explore processes involved in proper sperm motility. A vaccine which induces an immune response to the reproductive system is also an interesting method. The latest research use ultrasound waves and mechanical device which blocks the patency of vas deferens. The aim of the study current state of knowledge male contraception.
authors: Medical University of Wrocław, Poland: Department of Endocrinology, Diabetes and Radionuclide Therapy.
authors: Zygmynt
authors: Z
authors: Zdrojewicz
authors: Medical University of Wrocław, Poland: Medical Department.
authors: Karolina
authors: K
authors: Kasperska
authors: Medical University of Wrocław, Poland: Medical Department.
authors: Marta
authors: M
authors: Lewandowska
mesh_terms: D017280:Condoms; D003267:Contraception; D005306:Fertilization; D012739:Gonadal Steroid Hormones; D006801:Humans; D008297:Male; D013091:Spermatogenesis / Q000187:drug effects; D014612:Vaccines; D014659:Vasectomy
chemical_list: D012739:Gonadal Steroid Hormones; D014612:Vaccines
keywords: BRDT; condom; contraception; man; testosterone