title: Codelivery of anticancer drugs and siRNA by mesoporous silica nanoparticles.
abstract: The most common method for cancer treatment is chemotherapy. Multidrug resistance (MDR) is one of the major obstacles in chemotherapeutic treatment of many human cancers. One strategy to overcome this challenge is the delivery of anticancer drugs and siRNA simultaneously using nanoparticles. Mesoporous silica nanoparticles are one of the most popular nanoparticles for cargo delivery because of their intrinsic porosity. This paper highlights recent advances in codelivery of chemotherapeutic and siRNA with mesoporous silica nanoparticles for cancer therapy. In addition, synthesis and functionalization approaches of these nanoparticles are summarized. This review presents insight into the utilization of nanoparticles and combination therapy to achieve more promising results in chemotherapy.
authors: Cellular & Molecular Research Center, Department of Pharmacology, School of Medicine, Birjand University of Medical Sciences, Birjand, Iran.
authors: Mohammad Yahya
authors: MY
authors: Hanafi-Bojd
authors: School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.
authors: Legha
authors: L
authors: Ansari
authors: Nanotechnology Research Center, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, PO Box 91775-1365 Mashhad, Iran.
authors: Bizhan
authors: B
authors: Malaekeh-Nikouei
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage*; D018432:Drug Resistance, Multiple; D006801:Humans; D053758:Nanoparticles; D009369:Neoplasms / Q000188:drug therapy*; D016062:Porosity; D034741:RNA, Small Interfering / Q000008:administration & dosage*; D012822:Silicon Dioxide
chemical_list: D000970:Antineoplastic Agents; D034741:RNA, Small Interfering; D012822:Silicon Dioxide
keywords: cancer; chemotherapy; codelivery; mesoporous silica nanoparticle; multidrug resistance; siRNA