title: Serum 25-Hydroxyvitamin D3 and Mammography Density among Mexican Women.
abstract: Low circulating levels of vitamin D and high mammographic density (MD) have been associated with higher risk of breast cancer. Although some evidence suggested an inverse association between circulating vitamin D and MD, no studies have investigated this association among Mexican women. We examined whether serum 25-hydroxyvitamin D3 [25(OH)D3] levels were associated with MD in a cross-sectional study nested within the large Mexican Teacher's Cohort. This study included 491 premenopausal women with a mean age of 42.9 years. Serum 25(OH)D3 levels were measured by liquid chromatography/tandem mass spectrometry. Linear regression and non-linear adjusted models were used to estimate the association of MD with serum 25(OH)D3. Median serum 25(OH)D3 level was 27.3 (23.3-32.8) (ng/ml). Forty one (8%) women had 25(OH)D3 levels in the deficient range (< 20 ng/ml). Body mass index (BMI) and total physical activity were significantly correlated with 25(OH)D3 (r = -0.109, P = 0.019 and r = 0.095, P = 0.003, respectively). In the multivariable linear regression, no significant association was observed between 25(OH)D3 levels and MD overall. However, in stratified analyses, higher serum 25(OH)D3 levels (≥27.3 ng/ml) were significantly inversely associated with percent MD among women with BMI below the median (β = -0.52, P = 0.047). Although no significant association was observed between serum 25(OH)D3 and percent MD in the overall population, specific subgroups of women may benefit from higher serum 25(OH)D3 levels.
authors: Nutrition and Metabolism Section, International Agency for Research on Cancer (IARC), Lyon, France.
authors: Amina
authors: A
authors: Amadou
authors: Nutrition and Metabolism Section, International Agency for Research on Cancer (IARC), Lyon, France.
authors: Carine
authors: C
authors: Biessy
authors: Nutrition and Metabolism Section, International Agency for Research on Cancer (IARC), Lyon, France.
authors: Sabina
authors: S
authors: Rinaldi
authors: Department of Epidemiology, Rollins School of Public Health, Winship Cancer Institute, Emory University, Atlanta, GA, United States of America.
authors: Veronika
authors: V
authors: Fedirko
authors: Nutrition and Metabolism Section, International Agency for Research on Cancer (IARC), Lyon, France.
authors: Nada
authors: N
authors: Assi
authors: Center for Research on Population Health, National Institute of Public Health, Cuernavaca, Mexico.|Department of Epidemiology, Harvard School of Public Health, Boston, MA, United States of America.
authors: Martin
authors: M
authors: Lajous
authors: Center for Research on Population Health, National Institute of Public Health, Cuernavaca, Mexico.
authors: Eduardo
authors: E
authors: Ortiz-Panozo
authors: Center for Research on Population Health, National Institute of Public Health, Cuernavaca, Mexico.
authors: Elsa
authors: E
authors: Yunes
authors: Center for Research on Population Health, National Institute of Public Health, Cuernavaca, Mexico.
authors: Ruy
authors: R
authors: Lopez-Ridaura
authors: Center for Research on Population Health, National Institute of Public Health, Cuernavaca, Mexico.
authors: Gabriela
authors: G
authors: Torres-Mejia
authors: Nutrition and Metabolism Section, International Agency for Research on Cancer (IARC), Lyon, France.|Center for Research on Population Health, National Institute of Public Health, Cuernavaca, Mexico.
authors: Isabelle
authors: I
authors: Romieu
mesh_terms: D000328:Adult; D000368:Aged; D015992:Body Mass Index; D000071060:Breast Density; D002112:Calcifediol / Q000097:blood*; D003430:Cross-Sectional Studies; D015444:Exercise; D005260:Female; D006710:Homocysteine / Q000097:blood*; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008327:Mammography; D008800:Mexico / Q000453:epidemiology; D008875:Middle Aged; D012044:Regression Analysis; D012307:Risk Factors; D014808:Vitamin D Deficiency / Q000097:blood
chemical_list: D006710:Homocysteine; D002112:Calcifediol