title: Chlamydia trachomatis infection and Vγ9Vδ2 Τ cells in women with recurrent spontaneous abortions.
abstract: Vγ9Vδ2 T cells (γ9δ2) are involved in antibacterial immune responses. The aim of this study was to look for associations between peripheral blood (PB) γ9δ2 T cells and cervix/vaginal Chlamydia trachomatis (Ct) infection in women with recurrent spontaneous abortions (RSA).
  
  
  
  Peripheral blood samples were obtained from 201 RSA women within 10 days after they experienced a new miscarriage. γ9δ2 T cells and their percentage in total γδ T cells were compared between women who had been found and women who had not been found infected with Ct (last 6 months). Fertile women (82) served as control subjects.
  
  
  
  The difference of mean percentages of γ9δ2 T cells between the abortion and control groups, and the Chlamydia (+) and Chlamydia (-) groups was highly statistically significant (P<.00001). Significant difference was also found between the Chlamydia (+) and Chlamydia (-) group and the control group (ANOVA).
  
  
  
  The measurement of γ9δ2T cells may be useful to suspect possibly undiagnosed chlamydial infection in RSA women.
authors: "Helena Venizelou" Maternity Hospital, Athens, Greece. ieronymos@hotmail.com.
authors: Ieronymos
authors: I
authors: Voskakis
authors: Immunology and Histocompatibility, "Helena Venizelou" Maternity Hospital, Athens, Greece.
authors: Christina
authors: C
authors: Tsekoura
authors: Immunology and Histocompatibility, "Helena Venizelou" Maternity Hospital, Athens, Greece.
authors: Theodora
authors: T
authors: Keramitsoglou
authors: "Helena Venizelou" Maternity Hospital, Athens, Greece.
authors: Evangelos
authors: E
authors: Tsantoulas
authors: Second Department of Obstetrics and Gynecology, Aretaieion Hospital, University of Athens Medical School, Athens, Greece.
authors: Efthimios
authors: E
authors: Deligeoroglou
authors: Second Department of Obstetrics, Aretaieion Hospital, University of Athens Medical School, Athens, Greece.
authors: George
authors: G
authors: Creatsas
authors: Immunology and Histocompatibility, "Helena Venizelou" Maternity Hospital, Athens, Greece.
authors: Marighoula
authors: M
authors: Varla-Leftherioti
mesh_terms: D000022:Abortion, Spontaneous; D000293:Adolescent; D000328:Adult; D015415:Biomarkers / Q000378:metabolism; D016022:Case-Control Studies; D002478:Cells, Cultured; D002690:Chlamydia Infections / Q000276:immunology*; D002692:Chlamydia trachomatis / Q000276:immunology*; D005260:Female; D006801:Humans; D018655:Lymphocyte Count; D016692:Receptors, Antigen, T-Cell, gamma-delta / Q000378:metabolism; D013601:T-Lymphocytes / Q000276:immunology*; D055815:Young Adult
chemical_list: D015415:Biomarkers; D016692:Receptors, Antigen, T-Cell, gamma-delta; C521523:T-cell receptor Vdelta2, human; C521522:T-cell receptor Vgamma9, human
keywords: Chlamydia trachomatis infection; recurrent spontaneous abortions; γ9δ2 T cells