title: Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis Associated with Acetaminophen Use during Viral Infections.
abstract: An association between drug treatment for viral infections and severe cutaneous adverse reactions has been noted. We investigated six patients diagnosed with Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) after being prescribed acetaminophen for suspected viral illnesses. Multiplex analysis was performed to measure cytokine levels in sera before and after treatment. IL-2Rα levels significantly decreased during the convalescence phase. Although acetaminophen is relatively safe, the drug can trigger SJS/TEN in patients with suspected viral infections. T-cells and monocytes may be key components of the link between viral infection and acetaminophen-induced SJS/TEN.
authors: Department of Allergy & Clinical Immunology, Ajou University School of Medicine, Suwon 16499, Korea.; Ajou Regional Pharmacovigilance Center, Ajou University Hospital, Suwon 16499, Korea.
authors: Ga-Young
authors: GY
authors: Ban
authors: Department of Allergy & Clinical Immunology, Ajou University School of Medicine, Suwon 16499, Korea.
authors: Seun-Joo
authors: SJ
authors: Ahn
authors: Department of Allergy & Clinical Immunology, Ajou University School of Medicine, Suwon 16499, Korea.
authors: Hye-Soo
authors: HS
authors: Yoo
authors: Department of Allergy & Clinical Immunology, Ajou University School of Medicine, Suwon 16499, Korea.
authors: Hae-Sim
authors: HS
authors: Park
authors: Department of Allergy & Clinical Immunology, Ajou University School of Medicine, Suwon 16499, Korea.; Ajou Regional Pharmacovigilance Center, Ajou University Hospital, Suwon 16499, Korea.
authors: Young-Min
authors: YM
authors: Ye
keywords: Acetaminophen; Severe cutaneous adverse reaction; Viral infection