title: Lethality of cytochalasin B and other compounds isolated from fungus Aspergillus sp. (Trichocomaceae) endophyte of Bauhinia guianensis (Fabaceae).
abstract: Endophytic fungi are fungi that colonize internal tissues of plants; several biologically active compounds have been isolated from these fungi. There are few studies of compounds isolated from endophytic fungi of Amazon plants. Thus, this study aimed the isolation and structural identification of ergosterol (1), ergosterol peroxide (2), mevalonolactone (3), cytochalasin B (4) and cytochalasin H (5) from Aspergillus sp. EJC 04, an endophytic fungus from Bauhinia guianensis. The cytochalasin B (4) and the diacetate derivative of cytochalasin B (4a) showed high lethality in the brine shrimp assay. This is the first occurrence of cytochalasins in Amazonian endophytic fungi from B. guianensis.
authors: Universidade Federal do Pará, Instituto de Ciências Exatas e Naturais-Programa de Pós-graduação em Química, Belém, Pará, Brazil.
authors: André de O
authors: AO
authors: Feitosa
authors: Universidade Federal do Pará, Instituto de Ciências Exatas e Naturais-Programa de Pós-graduação em Química, Belém, Pará, Brazil.
authors: Amanda Cristina S
authors: AC
authors: Dias
authors: Universidade Federal do Pará, Instituto de Ciências Exatas e Naturais-Programa de Pós-graduação em Química, Belém, Pará, Brazil.
authors: Gisele da C
authors: GD
authors: Ramos
authors: Universidade Federal do Pará, Instituto de Ciências Exatas e Naturais-Programa de Pós-graduação em Química, Belém, Pará, Brazil.
authors: Heriberto R
authors: HR
authors: Bitencourt
authors: Universidade Federal do Pará, Instituto de Ciências Exatas e Naturais-Programa de Pós-graduação em Química, Belém, Pará, Brazil.
authors: José Edson S
authors: JE
authors: Siqueira
authors: Universidade Federal do Pará, Instituto de Ciências Exatas e Naturais-Programa de Pós-graduação em Química, Belém, Pará, Brazil.
authors: Patrícia Santana B
authors: PS
authors: Marinho
authors: Universidade Federal do Paraná, Departamento de Química-Programa de Pós-graduação em Química, Curitiba, Paraná, Brazil.
authors: Andersson
authors: A
authors: Barison
authors: Universidade Federal do Paraná, Departamento de Química-Programa de Pós-graduação em Química, Curitiba, Paraná, Brazil.
authors: Fernanda M M
authors: FM
authors: Ocampos
authors: Universidade Federal do Pará, Instituto de Ciências Exatas e Naturais-Programa de Pós-graduação em Química, Belém, Pará, Brazil. Electronic address: andrey@ufpa.br.
authors: Andrey Moacir do R
authors: AM
authors: Marinho
mesh_terms: D000107:Acetylation; D000818:Animals; D001118:Argentina; D001156:Artemia / Q000187:drug effects*; D001230:Aspergillus / Q000737:chemistry* / Q000302:isolation & purification; D003571:Cytochalasin B / Q000737:chemistry / Q000302:isolation & purification / Q000633:toxicity*; D003572:Cytochalasins / Q000737:chemistry / Q000302:isolation & purification / Q000633:toxicity*; D060026:Endophytes / Q000737:chemistry* / Q000302:isolation & purification; D004875:Ergosterol / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification / Q000633:toxicity; D007887:Fabaceae / Q000382:microbiology*; D007928:Lethal Dose 50; D008798:Mevalonic Acid / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification / Q000633:toxicity; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D021241:Spectrometry, Mass, Electrospray Ionization; D013329:Structure-Activity Relationship
chemical_list: D003572:Cytochalasins; D003571:Cytochalasin B; C034891:cytochalasin H; C015367:mevalonolactone; D008798:Mevalonic Acid; C036071:ergosterol-5,8-peroxide; D004875:Ergosterol
keywords: Artemia salina; Endophytic fungi; Hongos endófitos; Metabolitos secundarios; Secondary metabolites