title: [Monitoring cytomegalovirus infection and reactivation using quantitative real-time polymerase chain reaction in patients with haematological malignancies during chemotherapy and after autologous stem cell transplantation].
abstract: BACKGROUND
  Because of the use of chemo-immunotherapeutic drugs, cytomegalovirus infection is one of the most important infectious complications among patients with haematological malignancies.
  
  
  OBJECTIVE
  The aim of the authors was to detect cytomegalovirus infection and reactivation using quantitative real-time polymerase chain reaction.
  
  
  METHODS
  Between 2012 and 2014, the authors retrospectively analysed 96 patient's medical history hospitalised in haematology Unit. Patients were grouped on the basis of their underlying diseases (lymphoprolipherative malignancies, acute leukaemias), and the following groups were created: autologous stem cell transplanted and non-transplanted groups.
  
  
  RESULTS
  Eighty-three patients were treated with lymphoprolipherative disorders, and 63 (76%) of them underwent autologous stem cell transplantation. Out of the 604 plasma specimens 46 (7.6%) were positive for the cytomegalovirus desoxyribonucleic acid collected from 25 patients [6 non-transplanted (18%) and 19 from the transplanted group (30.2%)]. The frequency of cytomegalovirus positivity was doubled in the transplanted patient group, however, reactivation was asymptomatic in 68% of the cases.
  
  
  CONCLUSIONS
  The routine use of cytomegalovirus monitoring is not necessary in this patient group. In case of suspected cytomegalovirus infection, molecular tests allow early preemptive antiviral therapy, which may decrease the mortality attributed to cytomegalovirus infection. Orv. Hetil., 2016, 157(35), 1403-1409.
authors: II. Belgyógyászati Klinika és Kardiológiai Központ, Szegedi Tudományegyetem, Általános Orvostudományi Kar Szeged, Semmelweis u. 8., 6721.
authors: Klára
authors: K
authors: Piukovics
authors: Klinikai Mikrobiológiai Diagnosztikai Intézet, Szegedi Tudományegyetem, Általános Orvostudományi Kar Szeged.
authors: Gabriella
authors: G
authors: Terhes
authors: II. Belgyógyászati Klinika és Kardiológiai Központ, Szegedi Tudományegyetem, Általános Orvostudományi Kar Szeged, Semmelweis u. 8., 6721.
authors: Ágnes
authors: Á
authors: Bereczki
authors: II. Belgyógyászati Klinika és Kardiológiai Központ, Szegedi Tudományegyetem, Általános Orvostudományi Kar Szeged, Semmelweis u. 8., 6721.
authors: Zita
authors: Z
authors: Borbényi
authors: II. Belgyógyászati Klinika és Kardiológiai Központ, Szegedi Tudományegyetem, Általános Orvostudományi Kar Szeged, Semmelweis u. 8., 6721.
authors: Tímea
authors: T
authors: Gurbity Pálfi
authors: Pathologiai Intézet, Szegedi Tudományegyetem, Általános Orvostudományi Kar Szeged.
authors: Bence
authors: B
authors: Kővári
authors: Klinikai Mikrobiológiai Diagnosztikai Intézet, Szegedi Tudományegyetem, Általános Orvostudományi Kar Szeged.
authors: Edit
authors: E
authors: Urbán
mesh_terms: D000998:Antiviral Agents / Q000627:therapeutic use; D003587:Cytomegalovirus / Q000302:isolation & purification*; D003586:Cytomegalovirus Infections / Q000175:diagnosis* / Q000276:immunology; D005260:Female; D006402:Hematologic Diseases / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy*; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D008297:Male; D060888:Real-Time Polymerase Chain Reaction; D012189:Retrospective Studies
chemical_list: D000998:Antiviral Agents
keywords: cytomegalovirus; cytomegalovirus (CMV); immunocompromised; immunszupprimált; molecular; molekuláris