title: Role of benign ovarian cysts in the development of adenomyosis.
abstract: OBJECTIVE
  To assess the association of adenomyotic foci with co-existing benign ovarian cysts.
  
  
  METHODS
  This prospective cross-sectional study consisted of 100 consecutive hysterectomy specimens referred to Histopathology Section of Pathology Department, Peshawar Medical College, Peshawar, Pakistan by its attached teaching hospitals from January 2011 to December 2012. Hematoxylin and eosin stained sections were examined for adenomyotic foci and the presence of co-existent ovarian cysts. For evaluation of estrogen receptor (ER) status immunohistochemical stains were applied and H-scoring system was used with a score greater than 50 as positive.
  
  
  RESULTS
  Out of the 100 hysterectomy specimens, 25 cases had both adenomyosis and ovarian cysts. The ER status of adenomyotic foci was positive in 20% cases and negative in 80% cases. The commonest type of ovarian cyst was hemorrhagic luteal cyst (28%), followed by serous and mucinous cystadenoma (20%) each. Out of the 28% cases of functional cysts, 71.5% were ER positive and 28.5% were ER negative. The p-value for association of ER status of adenomyotic foci with functional cysts was 0.0004; however, p-value was not significant in comparing cases with controls. All 72% cases of nonfunctional cysts were ER negative. However, 44% of functional cysts were not associated with adenomyotic foci.
  
  
  CONCLUSIONS
  This study concludes that besides functional ovarian cysts, other local factors may be responsible for the development of adenomyosis.
authors: Department of Pathology, Peshawar Medical college, Riphah International University, Islamabad, Pakistan. E-mail. shujamati@gmail.com.
authors: Sadaf
authors: S
authors: Alam
authors: Sajjad
authors: S
authors: Ahmad
authors: Muhammad M
authors: MM
authors: Khan
authors: Sabeen
authors: S
authors: Nasir
authors: Naveed
authors: N
authors: Sharif
authors: Sara
authors: S
authors: Ziaullah
authors: Ahmareen
authors: A
authors: Khalid
authors: Fozia
authors: F
authors: Rauf
mesh_terms: D062788:Adenomyosis / Q000150:complications*; D000328:Adult; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008875:Middle Aged; D010048:Ovarian Cysts / Q000150:complications*; D011446:Prospective Studies; D011960:Receptors, Estrogen / Q000032:analysis
chemical_list: D011960:Receptors, Estrogen