title: Maternal and neonatal outcomes after antenatal corticosteroid administration for PPROM at 32 to 33 6/7 weeks gestational age.
abstract: BACKGROUND
  Preterm Premature Rupture of Membranes (PPROM) precedes many deliveries and experts agree with expectant management until 34 weeks gestation. However, there is controversy regarding the gestational age (GA) for administration of corticosteroids.
  
  
  METHODS
  We performed a retrospective cohort study in the University of California Fetal Consortium (UCfC). We searched available charts of singleton pregnancies with PPROM between 32 and 33 6/7 weeks GA. Outcomes from the groups were analyzed.
  
  
  RESULTS
  Of 191 women with PPROM at 32 to 33 6/7 weeks, 150 received corticosteroids. The median GA at admission was earlier for the exposed versus unexposed group (32 4/7 versus 33 0/7 weeks, respectively, p = 0.001). The mean GA at delivery in the exposed was 33 2/7 (32 0/7 to 35 0/7) weeks versus 33 5/7 (32 0/7 to 36 1/7) weeks in the unexposed (p = 0.001). There was no difference in chorioamnionitis or RDS.
  
  
  CONCLUSIONS
  In women with PPROM at 32 to 33 6/7 weeks, our data suggests that corticosteroids are associated with similar outcomes despite earlier GA at delivery and no differences in major morbidities. A larger prospective study is needed to determine if the benefit of corticosteroids outweighs the potential risks in PPROM.
authors: a University of California, Irvine Health , Orange , CA , USA.
authors: Lili
authors: L
authors: Sheibani
authors: a University of California, Irvine Health , Orange , CA , USA.
authors: Alex
authors: A
authors: Fong
authors: b University of California, San Francisco, Medical Center , San Francisco , CA , USA.
authors: Dana E
authors: DE
authors: Henry
authors: b University of California, San Francisco, Medical Center , San Francisco , CA , USA.
authors: Mary E
authors: ME
authors: Norton
authors: c University of California, Davis, Medical Center , Sacramento , CA , USA.
authors: Yen N
authors: YN
authors: Truong
authors: d University of California, San Diego Medical Center , San Diego , CA , USA , and.
authors: Adanna
authors: A
authors: Anyikam
authors: d University of California, San Diego Medical Center , San Diego , CA , USA , and.
authors: Louise C
authors: LC
authors: Laurent
authors: e University of California, Los Angeles, Medical Center , Los Angeles , CA , USA.
authors: Rashmi
authors: R
authors: Rao
authors: a University of California, Irvine Health , Orange , CA , USA.
authors: Deborah A
authors: DA
authors: Wing
mesh_terms: D000293:Adolescent; D000305:Adrenal Cortex Hormones / Q000008:administration & dosage*; D000328:Adult; D005260:Female; D005322:Premature Rupture of Fetal Membranes; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D007235:Infant, Premature, Diseases / Q000517:prevention & control*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D055815:Young Adult
chemical_list: D000305:Adrenal Cortex Hormones
keywords: Preterm premature rupture of membranes; chorioamnionitis; corticosteroids; fetal membranes; neonatal sepsis; prematurity