title: BRD7 Acts as a Tumor Suppressor Gene in Lung Adenocarcinoma.
abstract: Lung cancer is one of the most malignant tumors and the leading cause of cancer-related deaths worldwide. Among lung cancers, 40% are diagnosed as adenocarcinoma. Bromodomain containing 7 (BRD7) is a member of bromodomain-containing protein family. It was proved to be downregulated in various cancers. However, the role of BRD7 in lung adenocarcinoma is still unknown. Western blot and qRT-PCR was performed to measure the BRD7 expression in lung adenocarcinoma tissues and cells. CCK8 and migration assay was done to detect the functional role of BRD7 in lung adenocarcinoma. In this study, we showed that the expression of BRD7 was downregulated in lung adenocarcinoma tissues and cells. The lower of BRD7 levels in patients with lung adenocarcinoma was associated with shortened disease-free survival. Furthermore, overexpression of BRD7 inhibited lung adenocarcinoma cell proliferation and migration. Inhibition of BRD7 expression promoted cell proliferation and migration by activating ERK phosphorylation. Overexpression of BRD7 inhibited cyclin D and myc expression. Our findings are consistent with a tumor suppressor role for BRD7 in lung adenocarcinoma tumorigenesis.
authors: Department of thoracic surgical oncology, cancer institute (hospital), Chinese academy of medical sciences, Peking union medical college, Beijing, 100021, China.
authors: Yushun
authors: Y
authors: Gao
authors: Department of thoracic surgical oncology, cancer institute (hospital), Chinese academy of medical sciences, Peking union medical college, Beijing, 100021, China.
authors: Bing
authors: B
authors: Wang
authors: Department of thoracic surgical oncology, cancer institute (hospital), Chinese academy of medical sciences, Peking union medical college, Beijing, 100021, China.
authors: Shugeng
authors: S
authors: Gao
mesh_terms: D000072283:A549 Cells; D000230:Adenocarcinoma / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D002465:Cell Movement; D002868:Chromosomal Proteins, Non-Histone / Q000096:biosynthesis* / Q000235:genetics; D056741:Cyclin D / Q000096:biosynthesis / Q000235:genetics; D048049:Extracellular Signal-Regulated MAP Kinases / Q000235:genetics / Q000378:metabolism; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D020935:MAP Kinase Signaling System; D008297:Male; D025521:Tumor Suppressor Proteins / Q000096:biosynthesis* / Q000235:genetics; D000092468:Bromodomain Containing Proteins
chemical_list: D002868:Chromosomal Proteins, Non-Histone; D056741:Cyclin D; D048049:Extracellular Signal-Regulated MAP Kinases; D025521:Tumor Suppressor Proteins; C485694:BRD7 protein, human; D000092468:Bromodomain Containing Proteins