title: Selective bromochlorination of a homoallylic alcohol for the total synthesis of (-)-anverene.
abstract: The scope of a recently reported method for the catalytic enantioselective bromochlorination of allylic alcohols is expanded to include a specific homoallylic alcohol. Critical factors for optimization of this reaction are highlighted. The utility of the product bromochloride is demonstrated by the first total synthesis of an antibacterial polyhalogenated monoterpene, (-)-anverene.
authors: Department of Chemistry, Stanford University, Stanford, California 94305, USA.
authors: Frederick J
authors: FJ
authors: Seidl
authors: Department of Chemistry, Stanford University, Stanford, California 94305, USA.
authors: Noah Z
authors: NZ
authors: Burns
keywords: enantioselective catalysis; halogenation; natural products; total synthesis