title: [Turner syndrome: Study of 42 cases].
abstract: OBJECTIVE
  Turner syndrome (TS) is characterized by short stature, gonadal dysgenesis, and total or partial loss of X chromosome.
  
  
  METHODS
  A historical cohorts study of patients with TS≤18 years old followed up in public hospitals in Castilla y Leon was undertaken.
  
  
  RESULTS
  Forty-two female patients were included (prenatal diagnosis 11.9%, neonatal diagnosis 14.3%) with current median age 11.9±4.2 years. Short stature was the reason for consultation in 87.1%. Total monosomy of X chromosome was present in 40.5%. The most frequently associated comorbidity was opthalmological (50%), with heart defects in 23.8%. Ninety-three percent were treated with growth hormone (GH), mean age at the beginning of treatment was 7.43±3.4 years and mean height standard deviation was -2.84±1.08. Final height was reached in 10 patients only (mean final height 151.47±6.09cm). Chronological age of puberty induction was 13.2±0.94 years (bone age 12.47±1.17 years).
  
  
  CONCLUSIONS
  Short stature was an important clinical sign for the diagnosis of TS, accompanied in some cases by other findings, with good response to GH treatment.
authors: Hospital Clínico Universitario de Valladolid, Valladolid, España. Electronic address: pilarbahilloc@yahoo.es.
authors: M Pilar
authors: MP
authors: Bahíllo-Curieses
authors: Hospital Universitario de Salamanca, Instituto de Investigación Biomédica de Salamanca, Salamanca, España.
authors: Pablo
authors: P
authors: Prieto-Matos
authors: Complejo Asistencial Universitario de León, León, España.
authors: Rocío
authors: R
authors: Quiroga González
authors: Complejo Asistencial Universitario de León, León, España.
authors: Laura
authors: L
authors: Regueras Santos
authors: Complejo Asistencial Universitario de Burgos, Burgos, España.
authors: Amaya
authors: A
authors: Blanco Barrio
authors: Complejo Asistencial de Ávila, Ávila, España.
authors: Sara
authors: S
authors: Rupérez Peña
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D005260:Female; D005500:Follow-Up Studies; D013006:Growth Hormone / Q000627:therapeutic use; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D011379:Prognosis; D012189:Retrospective Studies; D014424:Turner Syndrome / Q000150:complications / Q000175:diagnosis* / Q000235:genetics / Q000628:therapy
chemical_list: D013006:Growth Hormone
keywords: Growth hormone; Hormona de crecimiento; Short stature; Síndrome de Turner; Talla baja; Turner syndrome