title: Implementing informative priors for heterogeneity in meta-analysis using meta-regression and pseudo data.
abstract: Many meta-analyses combine results from only a small number of studies, a situation in which the between-study variance is imprecisely estimated when standard methods are applied. Bayesian meta-analysis allows incorporation of external evidence on heterogeneity, providing the potential for more robust inference on the effect size of interest. We present a method for performing Bayesian meta-analysis using data augmentation, in which we represent an informative conjugate prior for between-study variance by pseudo data and use meta-regression for estimation. To assist in this, we derive predictive inverse-gamma distributions for the between-study variance expected in future meta-analyses. These may serve as priors for heterogeneity in new meta-analyses. In a simulation study, we compare approximate Bayesian methods using meta-regression and pseudo data against fully Bayesian approaches based on importance sampling techniques and Markov chain Monte Carlo (MCMC). We compare the frequentist properties of these Bayesian methods with those of the commonly used frequentist DerSimonian and Laird procedure. The method is implemented in standard statistical software and provides a less complex alternative to standard MCMC approaches. An importance sampling approach produces almost identical results to standard MCMC approaches, and results obtained through meta-regression and pseudo data are very similar. On average, data augmentation provides closer results to MCMC, if implemented using restricted maximum likelihood estimation rather than DerSimonian and Laird or maximum likelihood estimation. The methods are applied to real datasets, and an extension to network meta-analysis is described. The proposed method facilitates Bayesian meta-analysis in a way that is accessible to applied researchers. © 2016 The Authors. Statistics in Medicine Published by John Wiley & Sons Ltd.
authors: MRC Biostatistics Unit, Cambridge Institute of Public Health, Cambridge, U.K.
authors: Kirsty M
authors: KM
authors: Rhodes
authors: MRC Biostatistics Unit, Cambridge Institute of Public Health, Cambridge, U.K.
authors: Rebecca M
authors: RM
authors: Turner
authors: MRC Biostatistics Unit, Cambridge Institute of Public Health, Cambridge, U.K.
authors: Ian R
authors: IR
authors: White
authors: MRC Biostatistics Unit, Cambridge Institute of Public Health, Cambridge, U.K.
authors: Dan
authors: D
authors: Jackson
authors: Statistical Laboratory, Centre for Mathematical Sciences, University of Cambridge, U.K.
authors: David J
authors: DJ
authors: Spiegelhalter
authors: School of Social and Community Medicine, University of Bristol, U.K.
authors: Julian P T
authors: JP
authors: Higgins
mesh_terms: D001499:Bayes Theorem; D016013:Likelihood Functions; D008390:Markov Chains; D015201:Meta-Analysis as Topic; D009010:Monte Carlo Method
keywords: data augmentation; heterogeneity; informative priors; meta-analysis; meta-regression