title: Topographic changes in cerebral blood flow and reduced white matter integrity in the first 2 weeks following revascularization surgery in adult moyamoya disease.
abstract: OBJECTIVE After revascularization surgery, hyperperfusion and ischemia are associated with morbidity and mortality in adult moyamoya disease (MMD). However, structural changes within the brain following revascularization surgery, especially in the early postsurgical period, have not been thoroughly studied. Such knowledge may enable improved monitoring and clinical management of hyperperfusion and ischemia in MMD. Thus, the objective of this study was to investigate the topographic and temporal profiles of cerebral perfusion and related white matter microstructural changes following revascularization surgery in adult MMD. METHODS The authors analyzed 20 consecutive surgeries performed in 17 adults. Diffusion imaging in parallel with serial measurements of regional cerebral blood flow (rCBF) using SPECT was performed. Both voxel-based and region-of-interest analyses were performed, comparing neuroimaging parameters of postoperative hemispheres with those of preoperative hemispheres at 4 different time points within 2 weeks after surgery. RESULTS Voxel-based analysis showed a distinct topographic pattern of cerebral perfusion, characterized by increased rCBF in the basal ganglia for the first several days and gradually increased rCBF in the lateral prefrontal cortex over 1 week (p < 0.001). Decreased rCBF was also observed in the lateral prefrontal cortex, occipital lobe, and cerebellum contralateral to the surgical hemisphere (p < 0.001). Reduced fractional anisotropy (FA) and axial diffusivity (AD), as well as increased radial diffusivity (RD), were demonstrated in both the anterior and posterior limbs of the internal capsule (p < 0.001). Diffusion parameters demonstrated the greatest changes in both FA and RD on Days 1-2 and in AD on Days 3-6; FA, RD, and AD recovered to preoperative levels on Day 14. Patients with transient neurological deteriorations (TNDs), as compared with those without, demonstrated greater increases in rCBF in both the lateral prefrontal cortex and striatum as well as smaller FAs in the posterior limb of the internal capsule (p < 0.05). CONCLUSIONS The excessively increased rCBF and the recovery process were heterogeneous across brain regions, demonstrating a distinct topographic pattern during the initial 2 weeks following revascularization surgery in MMD. Temporary impairments in the deep white matter tract and immediate postoperative ischemia were also identified. The study results characterized postoperative brain perfusion as well as the impact of revascularization surgery on the brain microstructure. Notably, rCBF and white matter changes correlated to TNDs, suggesting that these changes represent potential neuroimaging markers for tracking tissue structural changes associated with hyperperfusion during the acute postoperative period following revascularization surgery for MMD.
authors: Departments of Neurosurgery.
authors: Ken
authors: K
authors: Kazumata
authors: Radiobiology and Medical Engineering, and.
authors: Khin Khin
authors: KK
authors: Tha
authors: Departments of Neurosurgery.
authors: Haruto
authors: H
authors: Uchino
authors: Nuclear Medicine, Hokkaido University Graduate School of Medicine, Sapporo, Japan.
authors: Tohru
authors: T
authors: Shiga
authors: Departments of Neurosurgery.
authors: Hideo
authors: H
authors: Shichinohe
authors: Departments of Neurosurgery.
authors: Masaki
authors: M
authors: Ito
authors: Departments of Neurosurgery.
authors: Naoki
authors: N
authors: Nakayama
authors: Departments of Neurosurgery.
authors: Takeo
authors: T
authors: Abumiya
mesh_terms: D000328:Adult; D002548:Cerebral Revascularization; D002560:Cerebrovascular Circulation; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009072:Moyamoya Disease / Q000503:physiopathology* / Q000601:surgery*; D011184:Postoperative Period; D011446:Prospective Studies; D013997:Time Factors; D066127:White Matter / Q000473:pathology*; D055815:Young Adult
keywords: AD = axial diffusivity; DKI = diffusion kurtosis imaging; DTI = diffusion tensor imaging; FA = fractional anisotropy; MAP = mean arterial pressure; MCA = middle cerebral artery; MK = mean kurtosis; MMD = moyamoya disease; MNI = Montreal Neurological Institute; MPRAGE = magnetization-prepared rapid gradient-echo; RD = radial diffusivity; RK = radial kurtosis; ROI = region of interest; SPM8 = Statistical Parametric Mapping version 8; STA = superficial temporal artery; TND = transient neurological deterioration; diffusion tensor imaging; hyperperfusion; moyamoya disease; rCBF = regional cerebral blood flow; regional cerebral blood flow; statistical parametric mapping; vascular disorders; white matter