title: Inflammatory Biomarkers Profile as Microenvironmental Expression in Keratoconus.
abstract: Keratoconus is a degenerative disorder with progressive stromal thinning and transformation of the normal corneal architecture towards ectasia that results in decreased vision due to irregular astigmatism and irreversible tissue scarring. The pathogenesis of keratoconus still remains unclear. Hypotheses that this condition has an inflammatory etiopathogenetic component apart from the genetic and environmental factors are beginning to escalate in the research domain. This paper covers the most relevant and recent published papers regarding the biomarkers of inflammation, their signaling pathway, and the potentially new therapeutic options in keratoconus.
authors: Clinical Hospital of Ophthalmologic Emergencies (SCUO), Piața Alexandru Lahovari 1, Bucharest, Romania.
authors: Catalina
authors: 0000-0002-4201-7033
authors: C
authors: Ionescu
authors: Clinical Hospital of Ophthalmologic Emergencies (SCUO), Piața Alexandru Lahovari 1, Bucharest, Romania; Division of Ophthalmology, Faculty of Medicine, "Carol Davila" University of Medicine and Pharmacy, Bulevardul Eroii Sanitari 8, 050474 Bucharest, Romania.
authors: Catalina Gabriela
authors: 0000-0001-7274-0903
authors: CG
authors: Corbu
authors: Biochemistry-Proteomics Department, Victor Babes National Institute of Pathology, Sector 5, 050096 Bucharest, Romania; Faculty of Medicine, Titu Maiorescu University, Dâmbovnicului Street 22, 040441 Bucharest, Romania.
authors: Cristiana
authors: 0000-0002-2122-0235
authors: C
authors: Tanase
authors: Department of Ophthalmology, Charité University Hospital, Campus Benjamin Franklin, Hindenburgdamm 30, 12203 Berlin, Germany.
authors: Christian
authors: C
authors: Jonescu-Cuypers
authors: Division of Ophthalmology, Faculty of Medicine, University of Medicine and Pharmacy "Iuliu Hatieganu" Cluj-Napoca, Victor Babes Street 8, 400012 Cluj-Napoca, Romania; Clinical Emergency Hospital Cluj-Napoca, Clinicilor Street 3-5, 400006 Cluj-Napoca, Romania.
authors: Cristina
authors: C
authors: Nicula
authors: Clinical Hospital of Ophthalmologic Emergencies (SCUO), Piața Alexandru Lahovari 1, Bucharest, Romania.
authors: Dana
authors: 0000-0001-6421-9675
authors: D
authors: Dascalescu
authors: Clinical Hospital of Ophthalmologic Emergencies (SCUO), Piața Alexandru Lahovari 1, Bucharest, Romania.
authors: Miruna
authors: 0000-0002-9701-4104
authors: M
authors: Cristea
authors: Division of Ophthalmology, Faculty of Medicine, "Carol Davila" University of Medicine and Pharmacy, Bulevardul Eroii Sanitari 8, 050474 Bucharest, Romania; Department of Ophthalmology, University Emergency Hospital, Splaiul Independenței 169, 050098 Bucharest, Romania.
authors: Liliana-Mary
authors: LM
authors: Voinea
mesh_terms: D015415:Biomarkers / Q000378:metabolism; D016207:Cytokines / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D007249:Inflammation / Q000378:metabolism; D007640:Keratoconus / Q000378:metabolism* / Q000473:pathology; D020782:Matrix Metalloproteinases / Q000235:genetics / Q000378:metabolism; D015398:Signal Transduction
chemical_list: D015415:Biomarkers; D016207:Cytokines; D020782:Matrix Metalloproteinases