title: Neural signature of behavioural inhibition in women with bulimia nervosa.
abstract: Impaired inhibitory control is considered a behavioural phenotype in patients with bulimia nervosa. However, the underlying neural correlates of impaired general and food-specific behavioural inhibition are largely unknown. Therefore, we investigated brain activation during the performance of behavioural inhibition to general and food-related stimuli in adults with bulimia nervosa.
  
  
  
  Women with bulimia and healthy control women underwent event-related fMRI while performing a general and a food-specific no-go task.
  
  
  
  We included 28 women with bulimia nervosa and 29 healthy control women in our study. On a neuronal level, we observed significant group differences in response to general no-go stimuli in women with bulimia nervosa with high symptom severity; compared with healthy controls, the patients showed reduced activation in the right sensorimotor area (postcentral gyrus, precentral gyrus) and right dorsal striatum (caudate nucleus, putamen).
  
  
  
  The present results are limited to adult women with bulimia nervosa. Furthermore, it remains unclear whether impaired behavioural inhibition in patients with this disorder are a cause or consequence of chronic illness.
  
  
  
  Our findings suggest that diminished frontostriatal brain activation in patients with bulimia nervosa contribute to the severity of binge eating symptoms. Gaining further insight into the neural mechanisms of behavioural inhibition problems in individuals with this disorder may inform brain-directed treatment approaches and the development of response inhibition training approaches to improve inhibitory control in patients with bulimia nervosa. The present study does not support greater behavioural and neural impairments to food-specific behavioural inhibition in these patients.
authors: From the Departments of General Internal Medicine and Psychosomatics (Skunde, Walther, Simon, Wu, Herzog, Friederich) and General Adult Psychiatry (Walther), Centre for Psychosocial Medicine, University Hospital Heidelberg, Heidelberg, Germany; the Department of Psychosomatic Medicine and Psychotherapy, Medical Faculty, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany (Friederich, Simon); the Department of Psychology, College of Education, Shanghai Normal University, Shanghai, China (Wu); and the Department of Neuroradiology, University Hospital Heidelberg, Heidelberg, Germany (Bendszus).
authors: Mandy
authors: M
authors: Skunde
authors: From the Departments of General Internal Medicine and Psychosomatics (Skunde, Walther, Simon, Wu, Herzog, Friederich) and General Adult Psychiatry (Walther), Centre for Psychosocial Medicine, University Hospital Heidelberg, Heidelberg, Germany; the Department of Psychosomatic Medicine and Psychotherapy, Medical Faculty, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany (Friederich, Simon); the Department of Psychology, College of Education, Shanghai Normal University, Shanghai, China (Wu); and the Department of Neuroradiology, University Hospital Heidelberg, Heidelberg, Germany (Bendszus).
authors: Stephan
authors: S
authors: Walther
authors: From the Departments of General Internal Medicine and Psychosomatics (Skunde, Walther, Simon, Wu, Herzog, Friederich) and General Adult Psychiatry (Walther), Centre for Psychosocial Medicine, University Hospital Heidelberg, Heidelberg, Germany; the Department of Psychosomatic Medicine and Psychotherapy, Medical Faculty, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany (Friederich, Simon); the Department of Psychology, College of Education, Shanghai Normal University, Shanghai, China (Wu); and the Department of Neuroradiology, University Hospital Heidelberg, Heidelberg, Germany (Bendszus).
authors: Joe J
authors: JJ
authors: Simon
authors: From the Departments of General Internal Medicine and Psychosomatics (Skunde, Walther, Simon, Wu, Herzog, Friederich) and General Adult Psychiatry (Walther), Centre for Psychosocial Medicine, University Hospital Heidelberg, Heidelberg, Germany; the Department of Psychosomatic Medicine and Psychotherapy, Medical Faculty, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany (Friederich, Simon); the Department of Psychology, College of Education, Shanghai Normal University, Shanghai, China (Wu); and the Department of Neuroradiology, University Hospital Heidelberg, Heidelberg, Germany (Bendszus).
authors: Mudan
authors: M
authors: Wu
authors: From the Departments of General Internal Medicine and Psychosomatics (Skunde, Walther, Simon, Wu, Herzog, Friederich) and General Adult Psychiatry (Walther), Centre for Psychosocial Medicine, University Hospital Heidelberg, Heidelberg, Germany; the Department of Psychosomatic Medicine and Psychotherapy, Medical Faculty, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany (Friederich, Simon); the Department of Psychology, College of Education, Shanghai Normal University, Shanghai, China (Wu); and the Department of Neuroradiology, University Hospital Heidelberg, Heidelberg, Germany (Bendszus).
authors: Martin
authors: M
authors: Bendszus
authors: From the Departments of General Internal Medicine and Psychosomatics (Skunde, Walther, Simon, Wu, Herzog, Friederich) and General Adult Psychiatry (Walther), Centre for Psychosocial Medicine, University Hospital Heidelberg, Heidelberg, Germany; the Department of Psychosomatic Medicine and Psychotherapy, Medical Faculty, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany (Friederich, Simon); the Department of Psychology, College of Education, Shanghai Normal University, Shanghai, China (Wu); and the Department of Neuroradiology, University Hospital Heidelberg, Heidelberg, Germany (Bendszus).
authors: Wolfgang
authors: W
authors: Herzog
authors: From the Departments of General Internal Medicine and Psychosomatics (Skunde, Walther, Simon, Wu, Herzog, Friederich) and General Adult Psychiatry (Walther), Centre for Psychosocial Medicine, University Hospital Heidelberg, Heidelberg, Germany; the Department of Psychosomatic Medicine and Psychotherapy, Medical Faculty, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany (Friederich, Simon); the Department of Psychology, College of Education, Shanghai Normal University, Shanghai, China (Wu); and the Department of Neuroradiology, University Hospital Heidelberg, Heidelberg, Germany (Bendszus).
authors: Hans-Christoph
authors: HC
authors: Friederich
mesh_terms: D000328:Adult; D001921:Brain / Q000000981:diagnostic imaging / Q000503:physiopathology*; D001931:Brain Mapping; D052018:Bulimia Nervosa / Q000000981:diagnostic imaging / Q000503:physiopathology* / Q000523:psychology*; D005260:Female; D005502:Food; D006801:Humans; D007266:Inhibition, Psychological; D008279:Magnetic Resonance Imaging; D009483:Neuropsychological Tests; D011597:Psychomotor Performance / Q000502:physiology*; D014796:Visual Perception / Q000502:physiology