title: Palliative Radiotherapy in Cancer Patients with Increased Serum C-Reactive Protein Level.
abstract: OBJECTIVE
  Connections exist between inflammation and cancer, for example with regard to disease progression and prognosis. Therefore, we investigated whether systemic inflammatory processes indicated by increased serum C-reactive protein (CRP) provide prognostic information for physicians prescribing palliative radiotherapy.
  
  
  METHODS
  We analyzed data from 781 patients and evaluated prognostic factors for survival.
  
  
  RESULTS
  Only 277 patients (35%) had CRP <8 mg/l before radiotherapy. No significant association was observed between CRP level and steroid treatment. In patients with the highest CRP level (>60 mg/l, 20% of patients), intravenous therapy with antibiotics was more common. CRP significantly influenced survival and contributed prognostic information together with established parameters, such as performance status (PS). In the multivariate model, white blood cell count did not provide relevant additional information. A simple four-tiered prognostic score solely based on CRP showed promising results.
  
  
  CONCLUSIONS
  Most patients treated with palliative radiotherapy had increased CRP. This widely available biomarker might improve decision-making and should be further validated.
authors: Department of Clinical Medicine, Faculty of Health Sciences, UiT - The Arctic University of Norway, Tromsø, Norway Department of Oncology and Palliative Medicine, Nordland Hospital, Bodø, Norway carsten.nieder@nlsh.no.
authors: Carsten
authors: C
authors: Nieder
authors: Department of Oncology and Palliative Medicine, Nordland Hospital, Bodø, Norway.
authors: Bård
authors: B
authors: Mannsåker
authors: Department of Clinical Medicine, Faculty of Health Sciences, UiT - The Arctic University of Norway, Tromsø, Norway Department of Oncology and Palliative Medicine, Nordland Hospital, Bodø, Norway.
authors: Astrid
authors: A
authors: Dalhaug
authors: Department of Oncology and Palliative Medicine, Nordland Hospital, Bodø, Norway.
authors: Adam
authors: A
authors: Pawinski
authors: Department of Oncology and Palliative Medicine, Nordland Hospital, Bodø, Norway.
authors: Ellinor
authors: E
authors: Haukland
mesh_terms: D000368:Aged; D002097:C-Reactive Protein / Q000378:metabolism*; D005260:Female; D006801:Humans; D007249:Inflammation / Q000097:blood* / Q000473:pathology / Q000532:radiotherapy; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis; D009369:Neoplasms / Q000097:blood* / Q000473:pathology / Q000532:radiotherapy*; D010166:Palliative Care
chemical_list: D002097:C-Reactive Protein
keywords: C-reactive protein; Palliative radiotherapy; antibiotics; inflammation; metastatic cancer; prognostic factors