title: MgII-Catalyzed Desymmetrization Reaction of meso-Aziridines with Hydroxylamines: Synthesis of Novel Chiral 1,2-Diamine Skeletons.
abstract: A MgII-catalyzed desymmetrization reaction of meso-aziridines with hydroxylamines has been disclosed for the first time. A series of novel chiral 1,2-diamine skeletons were obtained in good yields and enantioselectivities. The reaction employed magnesium catalysis generated in situ from a simple oxazoline-OH chiral ligand. Obviously, the diverse structures of the obtained chiral 1,2-diamine compounds could allow them to be potential chiral ligands in future catalytic asymmetric synthesis studies.
authors: Key Laboratory of Preclinical Study for New Drugs of Gansu Province, Lanzhou University, Lanzhou, 730000, P. R. China.
authors: Dan
authors: D
authors: Li
authors: Key Laboratory of Preclinical Study for New Drugs of Gansu Province, Lanzhou University, Lanzhou, 730000, P. R. China.
authors: Dongxu
authors: D
authors: Yang
authors: Key Laboratory of Preclinical Study for New Drugs of Gansu Province, Lanzhou University, Lanzhou, 730000, P. R. China.
authors: Linqing
authors: L
authors: Wang
authors: Key Laboratory of Preclinical Study for New Drugs of Gansu Province, Lanzhou University, Lanzhou, 730000, P. R. China.
authors: Xihong
authors: X
authors: Liu
authors: School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, 510006, P. R. China.
authors: Xianxing
authors: X
authors: Jiang
authors: Key Laboratory of Preclinical Study for New Drugs of Gansu Province, Lanzhou University, Lanzhou, 730000, P. R. China.
authors: Rui
authors: R
authors: Wang
keywords: asymmetric synthesis; diamines; hydroxylamine; magnesium; oxazoline