title: Stem Cell Fate Is a Touchy Subject.
abstract: Uncoupling synergistic interactions between physio-chemical cues that guide stem cell fate may improve efforts to direct their differentiation in culture. Using supramolecular hydrogels, Alakpa et al. (2016) demonstrate that mesenchymal stem cell differentiation is paired to depletion of bioactive metabolites, which can be utilized to chemically induce osteoblast and chondrocyte fate.
authors: Department of Chemical and Biomolecular Engineering, Institute for NanoBioTechnology, Johns Hopkins University, Baltimore, MD 21218, USA.
authors: Quinton
authors: Q
authors: Smith
authors: Department of Chemical and Biomolecular Engineering, Institute for NanoBioTechnology, Johns Hopkins University, Baltimore, MD 21218, USA; Department of Materials Science and Engineering, Johns Hopkins University, Baltimore, MD 21218, USA. Electronic address: gerecht@jhu.edu.
authors: Sharon
authors: S
authors: Gerecht
mesh_terms: D002454:Cell Differentiation; D019902:Chondrocytes / Q000166:cytology; D006801:Humans; D020100:Hydrogels / Q000737:chemistry; D059630:Mesenchymal Stem Cells / Q000166:cytology*; D013234:Stem Cells
chemical_list: D020100:Hydrogels