title: Mouse embryonic fibroblasts accumulate differentially on titanium surfaces treated with nanosecond laser pulses.
abstract: Biomaterial engineering, specifically in bone implant and osseointegration, is currently facing a critical challenge regarding the response of cells to foreign objects and general biocompatibility of the materials used in the production of these implants. Using the developing technology of the laser surface treatment, this study investigates the effects of the laser repetition rate (frequency) on cell distribution across the surface of the titanium substrates. The main objective of this research is building a fundamental understanding of how cells interact with treated titanium and how different treatments affect cell accumulation. Cells respond differently to surfaces treated with different frequency lasers. The results of this research identify the influence of frequency on surface topography properties and oxidation of titanium, and their subsequent effects on the pattern of cell accumulation on its surface. Despite increased oxidation in laser-treated regions, the authors observe that fibroblast cells prefer untreated titanium to laser-treated regions, except the regions treated with 25 kHz pulses, which become preferentially colonized after 72 h.
authors: Silicon Hall: Laser Micro/Nano Fabrication Facility, Department of Mechanical Engineering, University of New Brunswick, New Brunswick E3B 5A3, Canada.
authors: Mitra
authors: M
authors: Radmanesh
authors: Silicon Hall: Laser Micro/Nano Fabrication Facility, Department of Mechanical Engineering, University of New Brunswick, New Brunswick E3B 5A3, Canada and Department of Biology, University of New Brunswick, New Brunswick E3B 5A3, Canada.
authors: Amin M
authors: AM
authors: Ektesabi
authors: Department of Biology, University of New Brunswick, New Brunswick E3B 5A3, Canada.
authors: Rachael A
authors: RA
authors: Wyatt
authors: Department of Biology, University of New Brunswick, New Brunswick E3B 5A3, Canada.
authors: Bryan D
authors: BD
authors: Crawford
authors: Silicon Hall: Laser Micro/Nano Fabrication Facility, Department of Mechanical Engineering, University of New Brunswick, New Brunswick E3B 5A3, Canada.
authors: Amirkianoosh
authors: A
authors: Kiani
mesh_terms: D000818:Animals; D002448:Cell Adhesion; D005347:Fibroblasts / Q000502:physiology*; D007834:Lasers; D051379:Mice; D013499:Surface Properties / Q000528:radiation effects*; D014025:Titanium / Q000528:radiation effects*
chemical_list: D014025:Titanium