title: Artificial extracellular matrix for biomedical applications: biocompatible and biodegradable poly (tetramethylene ether) glycol/poly (ε-caprolactone diol)-based polyurethanes.
abstract: The cells as a tissue component need to viscoelastic, biocompatible, biodegradable, and wettable extracellular matrix for their biological activity. In this study, in order to prepare biomedical polyurethane elastomers with good mechanical behavior and biodegradability, a series of novel polyester-polyether- based polyurethanes (PUs) were synthesized using a two-step bulk reaction by melting pre-polymer method, taking 1,4-Butanediol (BDO) as chain extender, hexamethylene diisocyanate as the hard segment, and poly (tetramethylene ether) glycol (PTMEG) and poly (ε-caprolactone diol) (PCL-Diol) as the soft segment without a catalyst. The soft to the hard segment ratio was kept constant in all samples. Polyurethane characteristics such as thermal and mechanical properties, wettability and water adsorption, biodegradability, and cellular behavior were changed by changing the ratio of polyether diol to polyester diol composition in the soft segment. Our present work provides a new procedure for the preparation of engineered polyurethanes in surface properties and biodegradability, which could be a good candidate for bone, cartilage, and skin tissue engineering.
authors: a Department of Polymer Engineering & Color Technology , Amirkabir University of Technology , Tehran , Iran.
authors: Mohsen
authors: M
authors: Shahrousvand
authors: a Department of Polymer Engineering & Color Technology , Amirkabir University of Technology , Tehran , Iran.
authors: Gity
authors: G
authors: Mir Mohamad Sadeghi
authors: b Nanobiotechnology Research Center , Baqiyatallah University of Medical Sciences , Tehran , Iran.
authors: Ali
authors: A
authors: Salimi
mesh_terms: D040761:Biomimetic Materials / Q000737:chemistry* / Q000378:metabolism* / Q000494:pharmacology / Q000633:toxicity; D002072:Butylene Glycols / Q000737:chemistry; D002208:Caproates / Q000737:chemistry*; D002448:Cell Adhesion / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D005109:Extracellular Matrix / Q000378:metabolism*; D005347:Fibroblasts / Q000166:cytology / Q000187:drug effects; D006018:Glycols / Q000737:chemistry*; D017953:Isocyanates / Q000737:chemistry; D007783:Lactones / Q000737:chemistry*; D008422:Materials Testing; D011140:Polyurethanes / Q000737:chemistry*; D013696:Temperature
chemical_list: D002072:Butylene Glycols; D002208:Caproates; D006018:Glycols; D017953:Isocyanates; D007783:Lactones; D011140:Polyurethanes; C015262:1,6-hexamethylene diisocyanate; C047554:polytetramethylene glycol; C121056:caprolactone; C039681:1,4-butanediol
keywords: Biocompatible; biodegradable; biomedical application; polyurethanes; thermo-mechanical properties