title: Ideal Cardiovascular Health and Subclinical Markers of Carotid Structure and Function: The Paris Prospective Study III.
abstract: We hypothesized that subclinical markers of vascular structure and function, which are independent predictors of cardiovascular disease, would be less frequent in subjects with ideal than poor cardiovascular health (CVH) as defined by the American Heart Association (AHA).
  
  
  
  Carotid parameters were measured using high-precision echotracking device in 9155 nonreferred participants attending a health checkup in a large health center in Paris (France) between 2008 and 2012. According to the AHA, participants with 0 to 2, 3 to 4, and 5 to 7 metrics (smoking, physical activity, body mass index, diet, blood glucose and total cholesterol, blood pressure) at the ideal level were categorized as having poor, intermediate, and ideal CVH. Carotid parameters were dichotomized according to their median value, and multivariable logistic regression analysis was performed. Mean age was 59.5 (SD 6.3) years; 39% were females, and ideal CVH was present in 10.11% of the study participants. After adjustment for age, sex, education, and living alone and compared with a poor CVH, an ideal CVH was associated with lower common carotid artery intima-media thickness (odds ratio=1.64; 95% confidence interval 1.40, 1.93), absence of carotid plaques (odds ratio=2.14; 95% confidence interval 1.60, 2.87), lower Young's elastic modulus (odds ratio=2.43; 95% confidence interval 2.07, 2.84), and higher carotid distensibility coefficient (odds ratio=2.90; 95% confidence interval 2.47, 3.41).
  
  
  
  In community subjects aged 50 to 75 years, ideal CVH was associated with substantially less arterial stiffness and thickness. These associations might contribute to the lower risk of cardiovascular diseases in subjects with ideal CVH.
authors: From the INSERM, U970, Paris Cardiovascular Research Center, Department of Epidemiology, France (B.G., S.L., M.C.P., C.G., M.T., P.B., X.J., J.P.E.); Université Paris Descartes, Sorbonne Paris Cité, Faculté de Médecine, France (B.G., S.L., M.C.P., C.G., M.T., P.B., X.J., J.P.E.); APHP, Georges Pompidou European Hospital, Pharmacology Departments, Paris, France (S.L., P.B.); Preventive and Clinical Investigation Center, Paris, France (F.T., B.P.); APHP, Georges Pompidou European Hospital, Cardiology Department, Paris, France (X.J.); and Department of Cardiology, University Hospital of Geneva, Switzerland (H.M.). m.bamba.gaye@gmail.com.
authors: Bamba
authors: B
authors: Gaye
authors: From the INSERM, U970, Paris Cardiovascular Research Center, Department of Epidemiology, France (B.G., S.L., M.C.P., C.G., M.T., P.B., X.J., J.P.E.); Université Paris Descartes, Sorbonne Paris Cité, Faculté de Médecine, France (B.G., S.L., M.C.P., C.G., M.T., P.B., X.J., J.P.E.); APHP, Georges Pompidou European Hospital, Pharmacology Departments, Paris, France (S.L., P.B.); Preventive and Clinical Investigation Center, Paris, France (F.T., B.P.); APHP, Georges Pompidou European Hospital, Cardiology Department, Paris, France (X.J.); and Department of Cardiology, University Hospital of Geneva, Switzerland (H.M.).
authors: Hazrije
authors: H
authors: Mustafic
authors: From the INSERM, U970, Paris Cardiovascular Research Center, Department of Epidemiology, France (B.G., S.L., M.C.P., C.G., M.T., P.B., X.J., J.P.E.); Université Paris Descartes, Sorbonne Paris Cité, Faculté de Médecine, France (B.G., S.L., M.C.P., C.G., M.T., P.B., X.J., J.P.E.); APHP, Georges Pompidou European Hospital, Pharmacology Departments, Paris, France (S.L., P.B.); Preventive and Clinical Investigation Center, Paris, France (F.T., B.P.); APHP, Georges Pompidou European Hospital, Cardiology Department, Paris, France (X.J.); and Department of Cardiology, University Hospital of Geneva, Switzerland (H.M.).
authors: Stéphane
authors: S
authors: Laurent
authors: From the INSERM, U970, Paris Cardiovascular Research Center, Department of Epidemiology, France (B.G., S.L., M.C.P., C.G., M.T., P.B., X.J., J.P.E.); Université Paris Descartes, Sorbonne Paris Cité, Faculté de Médecine, France (B.G., S.L., M.C.P., C.G., M.T., P.B., X.J., J.P.E.); APHP, Georges Pompidou European Hospital, Pharmacology Departments, Paris, France (S.L., P.B.); Preventive and Clinical Investigation Center, Paris, France (F.T., B.P.); APHP, Georges Pompidou European Hospital, Cardiology Department, Paris, France (X.J.); and Department of Cardiology, University Hospital of Geneva, Switzerland (H.M.).
authors: Marie-Cécile
authors: MC
authors: Perier
authors: From the INSERM, U970, Paris Cardiovascular Research Center, Department of Epidemiology, France (B.G., S.L., M.C.P., C.G., M.T., P.B., X.J., J.P.E.); Université Paris Descartes, Sorbonne Paris Cité, Faculté de Médecine, France (B.G., S.L., M.C.P., C.G., M.T., P.B., X.J., J.P.E.); APHP, Georges Pompidou European Hospital, Pharmacology Departments, Paris, France (S.L., P.B.); Preventive and Clinical Investigation Center, Paris, France (F.T., B.P.); APHP, Georges Pompidou European Hospital, Cardiology Department, Paris, France (X.J.); and Department of Cardiology, University Hospital of Geneva, Switzerland (H.M.).
authors: Frédérique
authors: F
authors: Thomas
authors: From the INSERM, U970, Paris Cardiovascular Research Center, Department of Epidemiology, France (B.G., S.L., M.C.P., C.G., M.T., P.B., X.J., J.P.E.); Université Paris Descartes, Sorbonne Paris Cité, Faculté de Médecine, France (B.G., S.L., M.C.P., C.G., M.T., P.B., X.J., J.P.E.); APHP, Georges Pompidou European Hospital, Pharmacology Departments, Paris, France (S.L., P.B.); Preventive and Clinical Investigation Center, Paris, France (F.T., B.P.); APHP, Georges Pompidou European Hospital, Cardiology Department, Paris, France (X.J.); and Department of Cardiology, University Hospital of Geneva, Switzerland (H.M.).
authors: Catherine
authors: C
authors: Guibout
authors: From the INSERM, U970, Paris Cardiovascular Research Center, Department of Epidemiology, France (B.G., S.L., M.C.P., C.G., M.T., P.B., X.J., J.P.E.); Université Paris Descartes, Sorbonne Paris Cité, Faculté de Médecine, France (B.G., S.L., M.C.P., C.G., M.T., P.B., X.J., J.P.E.); APHP, Georges Pompidou European Hospital, Pharmacology Departments, Paris, France (S.L., P.B.); Preventive and Clinical Investigation Center, Paris, France (F.T., B.P.); APHP, Georges Pompidou European Hospital, Cardiology Department, Paris, France (X.J.); and Department of Cardiology, University Hospital of Geneva, Switzerland (H.M.).
authors: Muriel
authors: M
authors: Tafflet
authors: From the INSERM, U970, Paris Cardiovascular Research Center, Department of Epidemiology, France (B.G., S.L., M.C.P., C.G., M.T., P.B., X.J., J.P.E.); Université Paris Descartes, Sorbonne Paris Cité, Faculté de Médecine, France (B.G., S.L., M.C.P., C.G., M.T., P.B., X.J., J.P.E.); APHP, Georges Pompidou European Hospital, Pharmacology Departments, Paris, France (S.L., P.B.); Preventive and Clinical Investigation Center, Paris, France (F.T., B.P.); APHP, Georges Pompidou European Hospital, Cardiology Department, Paris, France (X.J.); and Department of Cardiology, University Hospital of Geneva, Switzerland (H.M.).
authors: Bruno
authors: B
authors: Pannier
authors: From the INSERM, U970, Paris Cardiovascular Research Center, Department of Epidemiology, France (B.G., S.L., M.C.P., C.G., M.T., P.B., X.J., J.P.E.); Université Paris Descartes, Sorbonne Paris Cité, Faculté de Médecine, France (B.G., S.L., M.C.P., C.G., M.T., P.B., X.J., J.P.E.); APHP, Georges Pompidou European Hospital, Pharmacology Departments, Paris, France (S.L., P.B.); Preventive and Clinical Investigation Center, Paris, France (F.T., B.P.); APHP, Georges Pompidou European Hospital, Cardiology Department, Paris, France (X.J.); and Department of Cardiology, University Hospital of Geneva, Switzerland (H.M.).
authors: Pierre
authors: P
authors: Boutouyrie
authors: From the INSERM, U970, Paris Cardiovascular Research Center, Department of Epidemiology, France (B.G., S.L., M.C.P., C.G., M.T., P.B., X.J., J.P.E.); Université Paris Descartes, Sorbonne Paris Cité, Faculté de Médecine, France (B.G., S.L., M.C.P., C.G., M.T., P.B., X.J., J.P.E.); APHP, Georges Pompidou European Hospital, Pharmacology Departments, Paris, France (S.L., P.B.); Preventive and Clinical Investigation Center, Paris, France (F.T., B.P.); APHP, Georges Pompidou European Hospital, Cardiology Department, Paris, France (X.J.); and Department of Cardiology, University Hospital of Geneva, Switzerland (H.M.).
authors: Xavier
authors: X
authors: Jouven
authors: From the INSERM, U970, Paris Cardiovascular Research Center, Department of Epidemiology, France (B.G., S.L., M.C.P., C.G., M.T., P.B., X.J., J.P.E.); Université Paris Descartes, Sorbonne Paris Cité, Faculté de Médecine, France (B.G., S.L., M.C.P., C.G., M.T., P.B., X.J., J.P.E.); APHP, Georges Pompidou European Hospital, Pharmacology Departments, Paris, France (S.L., P.B.); Preventive and Clinical Investigation Center, Paris, France (F.T., B.P.); APHP, Georges Pompidou European Hospital, Cardiology Department, Paris, France (X.J.); and Department of Cardiology, University Hospital of Geneva, Switzerland (H.M.).
authors: Jean-Philippe
authors: JP
authors: Empana
mesh_terms: D000367:Age Factors; D000368:Aged; D058070:Asymptomatic Diseases; D002339:Carotid Arteries / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D002340:Carotid Artery Diseases / Q000000981:diagnostic imaging* / Q000453:epidemiology / Q000503:physiopathology*; D059168:Carotid Intima-Media Thickness; D016009:Chi-Square Distribution; D003430:Cross-Sectional Studies; D055119:Elastic Modulus; D005260:Female; D006304:Health Status; D006801:Humans; D008019:Life Style; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D016017:Odds Ratio; D010297:Paris / Q000453:epidemiology; D058226:Plaque, Atherosclerotic; D011237:Predictive Value of Tests; D011379:Prognosis; D011446:Prospective Studies; D012307:Risk Factors; D040242:Risk Reduction Behavior; D012737:Sex Factors; D012959:Socioeconomic Factors; D011795:Surveys and Questionnaires; D059289:Vascular Stiffness
keywords: arterial stiffness; carotid intima–media thickness; epidemiology; plaque; prevention; subclinical disease