title: [Association of inflammatory cytokines with bone turnover markers in type 1 diabetes].
abstract: BACKGROUND
  Diabetes mellitus (DM) adversely affects the skeleton and the physiological mechanisms implicated have not been explained sufficiently. Thus, the objective was to identify inflammatory cytokines (IL-1, IL-6 and TNF-alpha) in patients with T1DM and their association with markers of bone formation (sPINP) and markers of bone resorption (sCTX).
  
  
  METHODS
  We studied 62 patients of 18 years of age or more with T1DM. We determined the values of HbA1c, vitamin D, inflammatory cytokines, as well as those of markers of bone formation and of markers of bone resorption.
  
  
  RESULTS
  49 patients were female with a mean age of 33.5 years. We found values of HbA1c > 7.5 in 83 %, vitamin D of 16 ng/mL. In patients with HbA1c >7.5 we found a positive correlation between TNF-alpha and sCTX (r = 0.43, p = 0.05), IL-6 and sCTX (r = 0.48, p = 0.037). With a model of simple linear regression between IL-6 and sCTX, it was found a beta coefficient of 23.8 with a p = 0.030 (95 % CI = 2-45.6), ie.: for every unit increase in IL-6 there is a sCTX increase of 23.8 pg/mL.
  
  
  CONCLUSIONS
  We found a positive association between TNF-alpha and IL-6 with the marker of bone resorption (sCTX) in the group of patients with HbA1c > 7.5. The loss of metabolic control was associated with TNF-alpha and IL-6.
authors: Servicio de Endocrinología, Hospital de Especialidades, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Ciudad de México, México. vmendozazu@yahoo.com.
authors: Mario
authors: M
authors: Molina-Ayala
authors: Ruth Carmina
authors: RC
authors: Cruz-Soto
authors: Guadalupe
authors: G
authors: Vargas-Ortega
authors: Baldomero
authors: B
authors: González-Virla
authors: Aldo
authors: A
authors: Ferreira-Hermosillo
authors: Julián
authors: J
authors: Mac Gregor-Gooch
authors: Victoria
authors: V
authors: Mendoza-Zubieta
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D016723:Bone Remodeling; D024042:Collagen Type I / Q000097:blood*; D016207:Cytokines / Q000097:blood*; D003922:Diabetes Mellitus, Type 1 / Q000097:blood* / Q000503:physiopathology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D010446:Peptide Fragments / Q000097:blood*; D011347:Procollagen / Q000097:blood*
chemical_list: D015415:Biomarkers; D024042:Collagen Type I; D016207:Cytokines; D010446:Peptide Fragments; D011347:Procollagen; C047202:procollagen Type I N-terminal peptide
keywords: Bone density; Cytokines; Interleukins; Tumor necrosis factor-alpha; Type 1 diabetes mellitus