title: In Vivo Biological Evaluation of Polyurethane Nanostructures with Ursolic and Oleanolic Acids on Chemically-induced Skin Carcinogenesis.
abstract: OBJECTIVE
  Oleanolic and ursolic acids (OA and UA) are two pentacyclic triterpenes, ubiquitously spread in plants, previously known for their chemopreventive capacity on different types of cancer. The major pharmacological disadvantage of these phytocompounds is their poor water solubility, which often limits their applicability.
  
  
  METHODS
  Using the interfacial polycondensation combined with spontaneous emulsification technique, polyurethane nanostructures (PU) were synthetized in order to improve this problem. In order to test the in vivo chemopreventive potential of the two pure compounds, as well as the encapsulated compounds in PU used as drug carriers, a chemically-induced skin carcinogenesis model was constructed.
  
  
  RESULTS
  UA and OA have a moderate chemopreventive activity against tumors induced by 7,12-dimethylbenzantracene (DMBA) and 12-O-tetradecanoilphorbol-13-acetate (TPA) application. Incorporation of active agents in PU did not lead to increased chemopreventive effect.
  
  
  CONCLUSIONS
  PU is not a suitable formulation of UA and OA.
authors: Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Victor Babes University of Medicine and Pharmacy, Timisoara, Romania.
authors: Camelia
authors: C
authors: Oprean
authors: Department of Analitical Chemistry, Faculty of Pharmacy, Victor Babes University of Medicine and Pharmacy, Timisoara, Romania.
authors: Florin
authors: F
authors: Borcan
authors: Department of Pharmacognosy, Faculty of Pharmacy, Victor Babes University of Medicine and Pharmacy, Timisoara, Romania.
authors: Ioana
authors: I
authors: Pavel
authors: Department of Morphopathology, Faculty of Medicine, Victor Babes University of Medicine and Pharmacy, Timisoara, Romania.
authors: Alis
authors: A
authors: Dema
authors: Department of Pharmacognosy, Faculty of Pharmacy, Victor Babes University of Medicine and Pharmacy, Timisoara, Romania corina.danciu@umft.ro.
authors: Corina
authors: C
authors: Danciu
authors: Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Victor Babes University of Medicine and Pharmacy, Timisoara, Romania.
authors: Codruta
authors: C
authors: Soica
authors: Department of Toxicology, Faculty of Pharmacy, Victor Babes University of Medicine and Pharmacy, Timisoara, Romania.
authors: Cristina
authors: C
authors: Dehelean
authors: Student at Faculty of Pharmacy, Victor Babeş University of Medicine and Pharmacy, Timisoara, Romania.
authors: Andreea
authors: A
authors: Nicu
authors: Student at Faculty of Pharmacy, Victor Babeş University of Medicine and Pharmacy, Timisoara, Romania.
authors: Anamaria
authors: A
authors: Ardelean
authors: "Pius Brinzeu" Timişoara County Emergency Clinical Hospital, Timisoara, Romania.
authors: Mirabela
authors: M
authors: Cristea
authors: Department of Functional Sciences, Faculty of Medicine, Victor Babes University of Medicine and Pharmacy, Timisoara, Romania.
authors: Alexandra
authors: A
authors: Ivan
authors: Department of Functional Sciences, Faculty of Medicine, Victor Babes University of Medicine and Pharmacy, Timisoara, Romania.
authors: Calin
authors: C
authors: Tatu
authors: Department of Functional Sciences, Faculty of Medicine, Victor Babes University of Medicine and Pharmacy, Timisoara, Romania.
authors: Florina
authors: F
authors: Bojin
mesh_terms: D000818:Animals; D063646:Carcinogenesis / Q000187:drug effects; D004195:Disease Models, Animal; D004337:Drug Carriers / Q000008:administration & dosage / Q000737:chemistry; D006801:Humans; D051379:Mice; D049329:Nanostructures / Q000008:administration & dosage / Q000737:chemistry; D009828:Oleanolic Acid / Q000008:administration & dosage* / Q000737:chemistry; D011140:Polyurethanes / Q000008:administration & dosage* / Q000737:chemistry; D012878:Skin Neoplasms / Q000139:chemically induced / Q000188:drug therapy* / Q000473:pathology; D014315:Triterpenes / Q000008:administration & dosage* / Q000737:chemistry; D000097245:Ursolic Acid
chemical_list: D004337:Drug Carriers; D009828:Oleanolic Acid; D011140:Polyurethanes; D014315:Triterpenes; D000097245:Ursolic Acid
keywords: DMBA; Oleanolic acid; TPA; polyurethane nanostructures; ursolic acid