title: Benzodiazepine Allergy With Anesthesia Administration: A Review of Current Literature.
abstract: The incidence of anaphylactic/anaphylactoid reactions has been reported to vary between 1 : 3500 and 1 : 20,000 cases with a mortality rate ranging from 3 to 9%. Clinical signs present as skin rash, urticaria, angioedema, bronchospasm, tachycardia, bradycardia, and hypotension. Rapid identification and treatment are crucial to overall patient prognosis, as delayed intervention is associated with increased mortality. Diagnosis may be confirmed with clinical presentation, serum tryptase levels, and skin test results. While the main causative agents in anesthetic practice are typically neuromuscular blocking agents (NMBs), latex, and antibiotics, this review aims to discuss recognition, management, and preventive measures in perioperative anaphylactic/anaphylactoid reactions from benzodiazepine administration.
authors: Dentist Anesthesiologist, Greenville, South Carolina. Former Resident in Dental Anesthesiology, University of Pittsburgh, Pennsylvania.
authors: Elliot
authors: E
authors: Haybarger
authors: Resident in Dental Anesthesiology, University of Pittsburgh, Pennsylvania.
authors: Andrew S
authors: AS
authors: Young
authors: Professor and Chair, Department of Dental Anesthesiology, University of Pittsburgh, Pennsylvania.
authors: Joseph A
authors: JA
authors: Giovannitti
mesh_terms: D058109:Airway Management; D001569:Benzodiazepines / Q000009:adverse effects*; D004342:Drug Hypersensitivity / Q000175:diagnosis* / Q000517:prevention & control / Q000628:therapy; D006801:Humans
chemical_list: D001569:Benzodiazepines
keywords: Anaphylactoid reactions; Anaphylaxis; Benzodiazepine allergy; Diagnosis of anaphylaxis; Management of anaphylaxis