title: Epidemiology and Cytokine Levels among Children with Nosocomial Multidrug-Resistant Acinetobacter baumannii Complex in a Tertiary Hospital of Eastern China.
abstract: OBJECTIVE
  The present study was aimed at assessing the characteristics of children with nosocomial multidrug-resistant Acinetobacter baumannii complex (MDR ABC) in a tertiary hospital of eastern China. MDR ABC poses a serious threat to public health. However, information on nosocomial MDR ABC in children is lacking.
  
  
  METHODS
  This study retrospectively reviewed the cases in a tertiary hospital of eastern China between January 1, 2011, and December 31, 2014 (excluding outpatients).
  
  
  RESULTS
  A total of 377 non-duplicated nosocomial ABC isolates were collected from various samples including 200 (53.1%) MDR ABC isolates. Moreover, 158 of the 200 MDR ABC isolates were collected from intensive care units (ICUs; MDR constituent ratios, 62.5%), while 98 of the 200 MDR ABC isolates were collected from children older than 1 year (MDR constituent ratios, 62.8%). Multivariate logistic analysis revealed that being in the surgical intensive care unit (SICU), prolonged hospital stay, surgical intervention, and mechanical ventilation were independent risk factors for MDR acquisition among children with nosocomial ABC. The interleukin (IL)-6 level of children with nosocomial MDR ABC was significantly lower than that of the children with nosocomial non-MDR ABC.
  
  
  CONCLUSIONS
  Nosocomial MDR ABC infection is a serious concern in pediatric patients. Being in the SICU, prolonged hospital stay, surgical intervention, and mechanical ventilation increased the risk of nosocomial MDR ABC. IL-6 might be involved in developing nosocomial MDR ABC among children.
authors: Clinical Laboratory Department, Children's Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, China.
authors: Chao
authors: C
authors: Fang
authors: Clinical Laboratory Department, Children's Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, China.
authors: Xuejun
authors: X
authors: Chen
authors: Clinical Laboratory Department, Children's Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, China.
authors: Mingming
authors: M
authors: Zhou
mesh_terms: D000151:Acinetobacter Infections / Q000097:blood / Q000453:epidemiology; D040981:Acinetobacter baumannii; D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D002681:China / Q000453:epidemiology; D003428:Cross Infection / Q000097:blood / Q000453:epidemiology; D024901:Drug Resistance, Multiple, Bacterial; D005260:Female; D006801:Humans; D007223:Infant; D015850:Interleukin-6 / Q000097:blood*; D008297:Male; D012189:Retrospective Studies; D062606:Tertiary Care Centers
chemical_list: C508600:IL6 protein, human; D015850:Interleukin-6