title: T follicular helper cells in space-time.
abstract: T follicular helper (TFH) cells play a crucial part in the development of humoral immunity by controlling the formation of, and the cellular reactions that occur in, germinal centres. Within these organized lymphoid tissue microstructures, B cells proliferate and somatically mutate to produce long-lived, high-affinity plasma cells and memory B cells. TFH cells exhibit unique molecular, cellular and tissue-dynamic features that are integral to their development and function but that are not necessarily compatible with the classical paradigm of effector CD4(+) T cell differentiation. Here, I discuss recent advances in TFH cell biology and their implications for our understanding of T cell differentiation and memory in humoral immunity from spatiotemporal and functional perspectives.
authors: Laboratory of Dynamic Immunobiology, Institute for Immunology, Department of Basic Biomedical Sciences, School of Medicine, Tsinghua-Peking Center for Life Sciences, Tsinghua University, Medical Science Building A107, Tsinghua University, Beijing 100084, China.
authors: Hai
authors: H
authors: Qi
mesh_terms: D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology / Q000378:metabolism; D002450:Cell Communication / Q000276:immunology; D002454:Cell Differentiation / Q000235:genetics / Q000276:immunology; D060966:Clonal Selection, Antigen-Mediated; D018858:Germinal Center / Q000276:immunology / Q000378:metabolism; D006801:Humans; D056724:Immunity, Humoral / Q000235:genetics / Q000276:immunology; D007156:Immunologic Memory; D054992:Immunological Synapses / Q000276:immunology; D008213:Lymphocyte Activation / Q000235:genetics / Q000276:immunology; D006377:T-Lymphocytes, Helper-Inducer / Q000166:cytology / Q000276:immunology* / Q000378:metabolism*