title: A versatile approach towards multi-functional surfaces via covalently attaching hydrogel thin layers.
abstract: In this study, a robust and straightforward method to covalently attach multi-functional hydrogel thin layers onto substrates was provided. In our strategy, double bonds were firstly introduced onto substrates to provide anchoring points for hydrogel layers, and then hydrogel thin layers were prepared via surface cross-linking copolymerization of the immobilized double bonds with functional monomers. Sulfobetaine methacrylate (SBMA), sodium allysulfonate (SAS), and methyl acryloyloxygen ethyl trimethyl ammonium chloride (METAC) were selected as functional monomers to form hydrogel layers onto polyether sulfone (PES) membrane surfaces, respectively. The thickness of the formed hydrogel layers could be controlled, and the layers showed excellent long-term stability. The PSBMA hydrogel layer exhibited superior antifouling property demonstrated by undetectable protein adsorption and excellent bacteria resistant property; after attaching PSAS hydrogel layer, the membrane showed incoagulable surface property when contacting with blood confirmed by the activated partial thromboplastin time (APTT) value exceeding 600s; while, the PMETAC hydrogel thin layer could effectively kill attached bacteria. The proposed method provides a new platform to directly modify material surfaces with desired properties, and thus has great potential to be widely used in designing materials for blood purification, drug delivery, wound dressing, and intelligent biosensors.
authors: College of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Sichuan University, Chengdu 610065, People's Republic of China.
authors: Min
authors: M
authors: He
authors: College of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Sichuan University, Chengdu 610065, People's Republic of China.
authors: Huiyi
authors: H
authors: Jiang
authors: College of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Sichuan University, Chengdu 610065, People's Republic of China.
authors: Rui
authors: R
authors: Wang
authors: College of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Sichuan University, Chengdu 610065, People's Republic of China.
authors: Yi
authors: Y
authors: Xie
authors: College of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Sichuan University, Chengdu 610065, People's Republic of China; Fiber and Polymer Technology, School of Chemical Science and Engineering, Royal Institute of Technology (KTH), Teknikringen 56-58, SE-100 44 Stockholm, Sweden. Electronic address: zhaoscukth@163.com.
authors: Weifeng
authors: W
authors: Zhao
authors: College of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Sichuan University, Chengdu 610065, People's Republic of China. Electronic address: zhaochsh70@163.com.
authors: Changsheng
authors: C
authors: Zhao
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D000925:Anticoagulants / Q000138:chemical synthesis* / Q000494:pharmacology; D001672:Biocompatible Materials / Q000138:chemical synthesis* / Q000494:pharmacology; D015926:Complement C3a / Q000737:chemistry; D015936:Complement C5a / Q000737:chemistry; D004926:Escherichia coli / Q000187:drug effects / Q000254:growth & development; D006801:Humans; D020100:Hydrogels / Q000138:chemical synthesis* / Q000494:pharmacology; D008297:Male; D008567:Membranes, Artificial; D008698:Mesylates / Q000737:chemistry; D008689:Methacrylates / Q000737:chemistry; D010314:Partial Thromboplastin Time; D011108:Polymers / Q000737:chemistry; D013211:Staphylococcus aureus / Q000187:drug effects / Q000254:growth & development; D013450:Sulfones / Q000737:chemistry
chemical_list: C120889:2-(trimethylammonio)ethyl methacrylate; D000900:Anti-Bacterial Agents; D000925:Anticoagulants; D001672:Biocompatible Materials; D020100:Hydrogels; D008567:Membranes, Artificial; D008698:Mesylates; D008689:Methacrylates; D011108:Polymers; D013450:Sulfones; C521589:sulfobetaine methacrylate polymer; C022840:polyether sulfone; C052010:allyl methanesulfonate; D015926:Complement C3a; D015936:Complement C5a
keywords: Anti-bacterial; Anticoagulation; Antifouling; Hydrogel thin layers; In situ crosslinking polymerization; Methyl acryloyloxygen ethyl trimethyl ammonium chloride; Poly(ether sulfone); Sodium allysulfonate; Sulfobetaine methacrylate; Surface attaching