title: Identification of Loci at 1q21 and 16q23 That Affect Susceptibility to Inflammatory Bowel Disease in Koreans.
abstract: Recent genome-wide association studies have identified more than 200 regions that affect susceptibility to inflammatory bowel disease (IBD). However, identified common variants account for only a fraction of IBD heritability and largely have been identified in populations of European ancestry. We performed a genome-wide association study of susceptibility loci in Korean individuals, comprising a total of 1505 IBD patients and 4041 controls. We identified 2 new susceptibility loci for IBD at genome-wide significance: rs3766920 near PYGO2-SHC1 at 1q21 and rs16953946 in CDYL2 at 16q23. In addition, we confirmed associations, in Koreans, with 28 established IBD loci (P < 2.16 × 10-4). Our findings support the complementary value of genetic studies in different populations.
authors: Department of Gastroenterology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
authors: Suk-Kyun
authors: SK
authors: Yang
authors: Department of Biochemistry and Molecular Biology, University of Ulsan College of Medicine, Seoul, Korea.
authors: Myunghee
authors: M
authors: Hong
authors: Department of Biochemistry and Molecular Biology, University of Ulsan College of Medicine, Seoul, Korea.
authors: Hyunjung
authors: H
authors: Oh
authors: Department of Biochemistry and Molecular Biology, University of Ulsan College of Medicine, Seoul, Korea.
authors: Hui-Qi
authors: HQ
authors: Low
authors: Department of Biochemistry and Molecular Biology, University of Ulsan College of Medicine, Seoul, Korea.
authors: Seulgi
authors: S
authors: Jung
authors: Department of Biochemistry and Molecular Biology, University of Ulsan College of Medicine, Seoul, Korea.
authors: Seonjoo
authors: S
authors: Ahn
authors: Department of Biochemistry and Molecular Biology, University of Ulsan College of Medicine, Seoul, Korea.
authors: Youngjin
authors: Y
authors: Kim
authors: Department of Biochemistry and Molecular Biology, University of Ulsan College of Medicine, Seoul, Korea.
authors: Jiwon
authors: J
authors: Baek
authors: Department of Convergence Medicine, University of Ulsan College of Medicine, Seoul, Korea; Asan Institute for Life Sciences, Asan Medical Center Children's Hospital, University of Ulsan College of Medicine, Seoul, Korea.
authors: Cue Hyunkyu
authors: CH
authors: Lee
authors: Department of Convergence Medicine, University of Ulsan College of Medicine, Seoul, Korea; Asan Institute for Life Sciences, Asan Medical Center Children's Hospital, University of Ulsan College of Medicine, Seoul, Korea; Department of Chemistry, Seoul National University, Seoul, Korea.
authors: Eunji
authors: E
authors: Kim
authors: Department of Pediatrics, Asan Medical Center Children's Hospital, University of Ulsan College of Medicine, Seoul, Korea.
authors: Kyung Mo
authors: KM
authors: Kim
authors: Department of Gastroenterology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
authors: Byong Duk
authors: BD
authors: Ye
authors: Department of Gastroenterology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
authors: Kyung-Jo
authors: KJ
authors: Kim
authors: Department of Gastroenterology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
authors: Sang Hyoung
authors: SH
authors: Park
authors: Department of Gastroenterology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
authors: Ho-Su
authors: HS
authors: Lee
authors: Department of Pathology, Asan Medical Center Children's Hospital, University of Ulsan College of Medicine, Seoul, Korea.
authors: Inchul
authors: I
authors: Lee
authors: Department of Life Science, Sogang University, Seoul, Korea.
authors: Hyoung Doo
authors: HD
authors: Shin
authors: Department of Convergence Medicine, University of Ulsan College of Medicine, Seoul, Korea; Asan Institute for Life Sciences, Asan Medical Center Children's Hospital, University of Ulsan College of Medicine, Seoul, Korea.
authors: Buhm
authors: B
authors: Han
authors: The F. Widjaja Foundation Inflammatory Bowel and Immunobiology Research Institute, Cedars-Sinai Medical Center, Los Angeles, California.
authors: Dermot P B
authors: DP
authors: McGovern
authors: Human Genetics Group, Genome Institute of Singapore, Singapore.
authors: Jianjun
authors: J
authors: Liu
authors: Department of Biochemistry and Molecular Biology, University of Ulsan College of Medicine, Seoul, Korea. Electronic address: kysong@amc.seoul.kr.
authors: Kyuyoung
authors: K
authors: Song
mesh_terms: D000293:Adolescent; D000328:Adult; D044466:Asian People / Q000235:genetics*; D016022:Case-Control Studies; D002878:Chromosomes, Human, Pair 1; D002885:Chromosomes, Human, Pair 16; D003093:Colitis, Ulcerative / Q000175:diagnosis / Q000235:genetics*; D003424:Crohn Disease / Q000175:diagnosis / Q000235:genetics*; D056426:Genetic Loci; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D005838:Genotype; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins / Q000235:genetics; D016013:Likelihood Functions; D020641:Polymorphism, Single Nucleotide; D056910:Republic of Korea; D000071425:Src Homology 2 Domain-Containing, Transforming Protein 1 / Q000235:genetics; D055815:Young Adult
chemical_list: D047908:Intracellular Signaling Peptides and Proteins; C453401:PYGO2 protein, human; C528024:SHC1 protein, human; D000071425:Src Homology 2 Domain-Containing, Transforming Protein 1
keywords: Crohn’s Disease; Genetics; Risk Factor; Ulcerative Colitis