title: Vancomycin heteroresistant community associated methicillin-resistant Staphylococcus aureus ST72-SCCmecIVa strain colonizing the nostrils of a five-year-old Spanish girl.
abstract: OBJECTIVE
  During a community methicillin-resistant Staphylococcus aureus (MRSA) nasal colonization study, an MRSA strain with vancomycin hetero-resistance (h-VISA) was isolated from a five year-old girl with tetralogy of Fallot without previous exposure to vancomycin. An extended nasal colonization study was performed on all her close relatives.
  
  
  RESULTS
  Only the patient and her sister were colonized by an h-VISA MRSA strain (clone USA 700, ST72, t148, agr 1 and SCCmec IVa). Mupirocin decolonisation was effective in the elder sister. A new nasal decolonisation in the younger girl using fusidic acid was also successful. However, after decolonisation both sisters were colonized by a methicillin-susceptible S. aureus (ST30, t012 and agr 3) previously isolated from their mother's nostrils.
  
  
  CONCLUSIONS
  As S. aureus have a great capacity to spread among people in close contact, knowledge of a patients' colonization status, tracing contacts, and a correct management are critical issues for the successful containment of multiresistant staphylococci.
authors: Laboratorio de Micología Médica, UFI 11/25 'Microbios y Salud', Departamento de Inmunología, Microbiología y Parasitología, Facultad de Medicina y Enfermería, Universidad del País Vasco/Euskal Herriko Unibertsitatea UPV/EHU, Bilbao, Spain.
authors: Aketza
authors: A
authors: Varona-Barquín
authors: Centro de Salud de Plentzia-Barrika, Plentzia, Bizkaia, Spain.
authors: Juan José
authors: JJ
authors: Iglesias-Losada
authors: Departamento de Medicina Preventiva y Salud Pública, UFI 11/25 'Microbios y Salud', Facultad de Medicina y Enfermería, Universidad del País Vasco/Euskal Herriko Unibertsitatea UPV/EHU, Bilbao, Spain; Servicio de Medicina Preventiva e Higiene Hospitalaria, Complejo Hospitalario de Navarra, Pamplona, Spain.
authors: Guillermo
authors: G
authors: Ezpeleta
authors: Laboratorio de Micología Médica, UFI 11/25 'Microbios y Salud', Departamento de Inmunología, Microbiología y Parasitología, Facultad de Medicina y Enfermería, Universidad del País Vasco/Euskal Herriko Unibertsitatea UPV/EHU, Bilbao, Spain.
authors: Elena
authors: E
authors: Eraso
authors: Laboratorio de Micología Médica, UFI 11/25 'Microbios y Salud', Departamento de Inmunología, Microbiología y Parasitología, Facultad de Medicina y Enfermería, Universidad del País Vasco/Euskal Herriko Unibertsitatea UPV/EHU, Bilbao, Spain. Electronic address: guillermo.quindos@ehu.eus.
authors: Guillermo
authors: G
authors: Quindós
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002675:Child, Preschool; D005260:Female; D006801:Humans; D055624:Methicillin-Resistant Staphylococcus aureus / Q000145:classification / Q000187:drug effects* / Q000302:isolation & purification*; D009296:Nasal Cavity / Q000382:microbiology*; D013030:Spain; D014640:Vancomycin / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D014640:Vancomycin
keywords: Clon USA 700; Clone USA 700; Colonización nasal; Fusidic acid; Heterorresistencia a vancomicina; Methicillin-resistant Staphylococcus aureus; Mupirocin; Mupirocina; Nasal colonisation; Staphylococcus aureus resistente a meticilina; Vancomicina; Vancomycin; Vancomycin hetero-resistance; Ácido fusídico