title: Effect of prenatal ethanol exposure on sexual motivation in adult rats.
abstract: Maternal alcohol use during pregnancy adversely affects prenatal and postnatal growth and increases the risk of behavioral deficits. The aim of the present study was to evaluate the effect of prenatal exposure to a moderate dose of alcohol on sexual motivation during adulthood. Rats were prenatally exposed to ethanol by feeding pregnant dams a liquid diet containing 25% ethanol-derived calories on days 6 through 19 of gestation. The controls consisted of pair-fed dams (receiving an isocaloric liquid diet containing 0% ethanol-derived calories) and dams with ad libitum access to a liquid control diet. The sexual motivation of offspring was evaluated during adulthood. The results revealed that the male and female pups of dams treated with alcohol exhibited reduced weight gain, which persisted until adulthood. Both male and female adult animals from dams that were exposed to alcohol showed a reduction in the preference score in the sexual motivation test. Taken together, these results provide evidence of the damaging effects of prenatal alcohol exposure on sexual motivation responses in adulthood.
authors: Programa Multicêntrico de Pós-Graduação em Ciências Fisiológicas, Sociedade Brasileira de Fisiologia (SBFis), Brazil.
authors: Mara Aparecida P
authors: MA
authors: Ávila
authors: Laboratório de Neuroendocrinologia Comportamental, Instituto de Ciências Biomédicas, Universidade Federal de Alfenas-MG, Alfenas, Brazil.
authors: Gabriela Cristina P
authors: GC
authors: Marthos
authors: Laboratório de Neuroendocrinologia Comportamental, Instituto de Ciências Biomédicas, Universidade Federal de Alfenas-MG, Alfenas, Brazil.
authors: Liliane Gibram M
authors: LG
authors: Oliveira
authors: Departamento de Análises Clínicas e Toxicológicas, Faculade de Ciências Farmacêuticas, Universidade Federal de Alfenas-MG, Alfenas, Brazil.
authors: Eduardo Costa
authors: EC
authors: Figueiredo
authors: Programa Multicêntrico de Pós-Graduação em Ciências Fisiológicas, Sociedade Brasileira de Fisiologia (SBFis), Brazil; Laboratório de Neuroendocrinologia Comportamental, Instituto de Ciências Biomédicas, Universidade Federal de Alfenas-MG, Alfenas, Brazil.
authors: Alexandre
authors: A
authors: Giusti-Paiva
authors: Laboratório de Neuroendocrinologia Comportamental, Instituto de Ciências Biomédicas, Universidade Federal de Alfenas-MG, Alfenas, Brazil. Electronic address: facvilela@gmail.com.
authors: Fabiana Cardoso
authors: FC
authors: Vilela
mesh_terms: D000818:Animals; D001835:Body Weight / Q000187:drug effects; D000431:Ethanol / Q000009:adverse effects* / Q000097:blood; D005260:Female; D008297:Male; D009042:Motivation / Q000187:drug effects*; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000523:psychology*; D051381:Rats; D017208:Rats, Wistar; D012726:Sexual Behavior, Animal / Q000187:drug effects*
chemical_list: D000431:Ethanol
keywords: Alcohol; Offspring; Sexual behavior; Sexual motivation test