title: Single dose and repeated administrations of liraglutide alter energy metabolism in the brains of young and adult rats.
abstract: Liraglutide is a human glucagon-like peptide-1 (GLP-1) analogue that was recently approved to treat obesity in some countries. Considering that liraglutide effects on brain energy metabolism are little known, we evaluated the effects of liraglutide on the energy metabolism. Animals received a single or daily injection of saline or liraglutide during 7 days (25, 50, 100, or 300 μg/kg i.p.). Twenty-four hours after the single or last injection, the rats were euthanized and the hypothalamus, prefrontal cortex, cerebellum, hippocampus, striatum, and posterior cortex were isolated. Our results demonstrated that a single dose of liraglutide in young rats increased the activity of complexes and inhibited creatine kinase activity. Repeated administrations of liraglutide in young rats reduced the activity of complexes and activated creatine kinase activity. In adult rats, a single dose of liraglutide reduced the activity of complex I and creatine kinase and increased the activity of complexes II and IV. Repeated administrations of liraglutide in adult rats increased the activity of complexes I and IV and reduced the activity of complex II and creatine kinase. We concluded that liraglutide may interfere in energy metabolism, because analysis of different times of administrations, concentrations, and level of brain development leads to divergent results.
authors: a Laboratory of Clinical and Experimental Pathophysiology, Postgraduate Program in Health Sciences, University of Southern Santa Catarina, Tubarão, 88704-900 SC, Brazil.
authors: Morgana
authors: M
authors: Prá
authors: b Laboratory Pharmacology and Pathophysiology of Skin, Department of Pharmacology, Federal University of Paraná, Curitiba, 81531-980 PR, Brazil.
authors: Gabriela Kozuchovski
authors: GK
authors: Ferreira
authors: a Laboratory of Clinical and Experimental Pathophysiology, Postgraduate Program in Health Sciences, University of Southern Santa Catarina, Tubarão, 88704-900 SC, Brazil.
authors: Aline Haas
authors: AH
authors: de Mello
authors: a Laboratory of Clinical and Experimental Pathophysiology, Postgraduate Program in Health Sciences, University of Southern Santa Catarina, Tubarão, 88704-900 SC, Brazil.
authors: Rosiane de Bona
authors: RB
authors: Schraiber
authors: a Laboratory of Clinical and Experimental Pathophysiology, Postgraduate Program in Health Sciences, University of Southern Santa Catarina, Tubarão, 88704-900 SC, Brazil.
authors: Larissa Colonetti
authors: LC
authors: Cardoso
authors: a Laboratory of Clinical and Experimental Pathophysiology, Postgraduate Program in Health Sciences, University of Southern Santa Catarina, Tubarão, 88704-900 SC, Brazil.
authors: Luana da Rosa
authors: LD
authors: Souza
authors: c Laboratory of Neuroscience, Postgraduate Program in Health Sciences, University of Southern Santa Catarina, Tubarão, 88704-900 SC, Brazil.
authors: Naiana
authors: N
authors: da Rosa
authors: c Laboratory of Neuroscience, Postgraduate Program in Health Sciences, University of Southern Santa Catarina, Tubarão, 88704-900 SC, Brazil.
authors: Jucélia Jeremias
authors: JJ
authors: Fortunato
authors: a Laboratory of Clinical and Experimental Pathophysiology, Postgraduate Program in Health Sciences, University of Southern Santa Catarina, Tubarão, 88704-900 SC, Brazil.
authors: Gislaine Tezza
authors: GT
authors: Rezin
mesh_terms: D000375:Aging; D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D003402:Creatine Kinase / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D042967:Electron Transport Complex I / Q000378:metabolism; D042963:Electron Transport Complex II / Q000378:metabolism; D014450:Electron Transport Complex III / Q000378:metabolism; D003576:Electron Transport Complex IV / Q000378:metabolism; D004734:Energy Metabolism / Q000187:drug effects*; D006801:Humans; D007004:Hypoglycemic Agents / Q000008:administration & dosage / Q000494:pharmacology*; D000069450:Liraglutide / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D051381:Rats; D017208:Rats, Wistar
chemical_list: D007004:Hypoglycemic Agents; D000069450:Liraglutide; D042963:Electron Transport Complex II; D003576:Electron Transport Complex IV; D003402:Creatine Kinase; D042967:Electron Transport Complex I; D014450:Electron Transport Complex III
keywords: GLP-1; energy metabolism; incretin system; liraglutide; métabolisme énergétique; obesity; obésité; système des incrétines