title: Soluble Suppression of Tumorigenicity 2 and Echocardiography in Sepsis.
abstract: Soluble suppression of tumorigenicity 2 (sST2) has emerged as a biomarker of cardiac stretch or remodeling, and has demonstrated a role in acutely decompensated heart failure. However, its role in sepsis-induced cardiac dysfunction is still unknown. We explored whether sST2 serum concentration reflects either systolic or diastolic dysfunction as measured by Doppler echocardiography. In a total of 127 patients with sepsis, correlations between sST2 and blood pressure, left ventricular (LV) ejection fraction, LV diastolic filling (ratio of early transmitral flow velocity to early diastolic mitral annulus velocity), and resting pulmonary arterial pressure were evaluated. Correlations between sST2 and other sepsis biomarkers (high-sensitivity C-reactive protein [hs-CRP] and procalcitonin) were also examined. sST2 showed a moderate correlation with mean arterial pressure (r=-0.3499) but no correlation with LV ejection fraction, diastolic filling, or resting pulmonary hypertension. It showed moderate correlations with hs-CRP and procalcitonin (r=0.2608 and r=0.3829, respectively). sST2 might have a role as a biomarker of shock or inflammation, but it cannot reflect echocardiographic findings of LV ejection fraction or diastolic filling in sepsis.
authors: Department of Cardiovascular Medicine, Konkuk University School of Medicine, Seoul, Korea.
authors: Hyun Suk
authors: HS
authors: Yang
authors: Department of Cardiovascular Medicine, Konkuk University School of Medicine, Seoul, Korea. dearmina@hanmail.net.
authors: Mina
authors: M
authors: Hur
authors: Department of Laboratory Medicine, Konkuk University School of Medicine, Seoul, Korea.
authors: Hanah
authors: H
authors: Kim
authors: Department of Medical-Surgery Sciences and Translational Medicine, University La Sapienza Rome, Sant'Andrea Hospital, Rome, Italy.
authors: Laura
authors: L
authors: Magrini
authors: Department of Medical-Surgery Sciences and Translational Medicine, University La Sapienza Rome, Sant'Andrea Hospital, Rome, Italy.
authors: Rossella
authors: R
authors: Marino
authors: Department of Medical-Surgery Sciences and Translational Medicine, University La Sapienza Rome, Sant'Andrea Hospital, Rome, Italy. salvatore.disomma@uniroma1.it.
authors: Salvatore
authors: S
authors: Di Somma
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood; D001794:Blood Pressure / Q000502:physiology; D002097:C-Reactive Protein / Q000032:analysis; D002116:Calcitonin / Q000097:blood; D015150:Echocardiography, Doppler; D005260:Female; D006801:Humans; D000072179:Interleukin-1 Receptor-Like 1 Protein / Q000097:blood*; D008297:Male; D008875:Middle Aged; D018805:Sepsis / Q000000981:diagnostic imaging / Q000378:metabolism / Q000503:physiopathology*; D016277:Ventricular Function, Left / Q000502:physiology
chemical_list: D015415:Biomarkers; C079241:IL1RL1 protein, human; D000072179:Interleukin-1 Receptor-Like 1 Protein; D002116:Calcitonin; D002097:C-Reactive Protein
keywords: Diastolic filling; Echocardiography; Left ventricular ejection fraction; Sepsis; sST2