title: Relative risk for cardiovascular morbidity in hemodialysis patients regarding gene polymorphism for IL-10, IL-6, and TNF.
abstract: Uremia-related inflammation is prone to be a key factor to explain high cardiovascular morbidity in hemodialysis patients. Genetic susceptibility may be of importance, including IL-10, IL-6, and TNF. The aim was to analyze IL-10, IL-6, and TNF gene polymorphisms in a group of hemodialysis patients and to correlate the findings with cardiovascular morbidity. This study included 169 patients on regular hemodialysis at Zvezdara University Medical Center. Gene polymorphisms for IL-10, IL-6 and TNF were determined using PCR. These findings were correlated with the cardiovascular morbidity data from patient histories. Heterozygots for IL-10 gene showed significantly lower incidence of cardiovascular events (p = 0.05) and twice lower risk for development of myocardial infarction, but experienced twice higher risk for left ventricular hypertrophy. Regarding TNF gene polymorphism, patients with A allele had 1.5-fold higher risk for cerebrovascular accident and cardiovascular events and 2-fold higher risk for hypertension and peripheral vascular disease. Patients with G allele of IL-6 gene experienced 1.5-fold higher risks for cerebrovascular accident. We need studies with larger number of patients for definitive conclusion about the influence of gene polymorphisms on cardiovascular morbidity in hemodialysis patients and its importance in everyday clinical practice.
authors: a Clinical Department for Renal Diseases, Zvezdara University Medical Center, Dimitrija Tucovica 161, 11000 Belgrade, Serbia.
authors: J
authors: J
authors: Tosic Dragovic
authors: a Clinical Department for Renal Diseases, Zvezdara University Medical Center, Dimitrija Tucovica 161, 11000 Belgrade, Serbia.
authors: J
authors: J
authors: Popovic
authors: a Clinical Department for Renal Diseases, Zvezdara University Medical Center, Dimitrija Tucovica 161, 11000 Belgrade, Serbia.
authors: P
authors: P
authors: Djuric
authors: a Clinical Department for Renal Diseases, Zvezdara University Medical Center, Dimitrija Tucovica 161, 11000 Belgrade, Serbia.
authors: A
authors: A
authors: Jankovic
authors: a Clinical Department for Renal Diseases, Zvezdara University Medical Center, Dimitrija Tucovica 161, 11000 Belgrade, Serbia.
authors: A
authors: A
authors: Bulatovic
authors: b Medical Faculty, Belgrade University, Dr Subotica 9, 11000 Belgrade, Serbia.
authors: M
authors: M
authors: Barovic
authors: b Medical Faculty, Belgrade University, Dr Subotica 9, 11000 Belgrade, Serbia.
authors: V
authors: V
authors: Pravica
authors: b Medical Faculty, Belgrade University, Dr Subotica 9, 11000 Belgrade, Serbia.
authors: J
authors: J
authors: Marinkovic
authors: a Clinical Department for Renal Diseases, Zvezdara University Medical Center, Dimitrija Tucovica 161, 11000 Belgrade, Serbia.|b Medical Faculty, Belgrade University, Dr Subotica 9, 11000 Belgrade, Serbia.
authors: N
authors: N
authors: Dimkovic
keywords: cardiovascular morbidity; cytokine; genetic polymorphism; hemodialysis; hémodialyse; morbidité cardiovasculaire; polymorphisme génétique