title: Systematic review shows that pathological lead points are important and frequent in intussusception and are not limited to infants.
abstract: Intussusception is the most clinically relevant cause of bowel obstruction in infancy and can be idiopathic or occur as a result of pathological lead points. The incidence of these pathological lead points varies from 0.3 to 20%, and they can be mucosal, intramural or extrinsic structures. A systematic literature review was performed from 1998 to 2016 to evaluate the incidence and types of pathological lead points in paediatric intussusception, and this identified 31 epidemiological and retrospective case cohort studies, reviews and case reports.
  
  
  CONCLUSIONS
  Pathological lead points were frequent in intussusceptions and not limited to infants.
authors: Department of Paediatric Surgery and Paediatric Urology, University Hospital of the Goethe-University Frankfurt/M., Frankfurt/M, Germany.
authors: Henning
authors: H
authors: Fiegel
authors: Department of Paediatric Surgery and Paediatric Urology, University Hospital of the Goethe-University Frankfurt/M., Frankfurt/M, Germany.
authors: Stefan
authors: S
authors: Gfroerer
authors: Department of Paediatric Surgery and Paediatric Urology, University Hospital of the Goethe-University Frankfurt/M., Frankfurt/M, Germany. udo.rolle@kgu.de.
authors: Udo
authors: U
authors: Rolle
mesh_terms: D017677:Age Distribution; D002648:Child; D002675:Child, Preschool; D006801:Humans; D015994:Incidence; D007223:Infant; D007415:Intestinal Obstruction / Q000175:diagnosis* / Q000453:epidemiology / Q000209:etiology / Q000628:therapy; D007443:Intussusception / Q000150:complications / Q000175:diagnosis* / Q000453:epidemiology / Q000628:therapy
keywords: Adenomyoma; Burkitt's lymphoma; Intussusception; Meckel's diverticulum; Pathological lead point