title: Role of osteopontin in lung cancer evolution and heterogeneity.
abstract: Patients with lung cancer still have high mortality, recurrence rate after adjuvant treatment, and poor five-year survival rates, despite of advances in multidisciplinary anti-cancer therapies, e.g. chemotherapy, radiotherapy and targeted therapies, It depends upon the presence of intratumoral heterogeneity and complexity of lung cancer. There is growing evidence to suggest that osteopontin (OPN) may play a critical role in tumor progression and metastasis. The present review briefly describes the structure and molecular biology of OPN, highlights the role of OPN in the development and metastasis of lung cancer, and summarizes potential mechanisms of OPN heterogeneity in tumor to underline some of these inconsistencies. The article will emphasize the importance to understand the role of OPN in cancer evolution and heterogeneity and explore the potential of OPN as a therapeutic target.
authors: Zhongshan Hospital Institute of Clinical Science, Shanghai Institute of Clinical Bioinformatics, Fudan University Center for Clinical Bioinformatics, Shanghai, China.
authors: Lin
authors: L
authors: Shi
authors: Zhongshan Hospital Institute of Clinical Science, Shanghai Institute of Clinical Bioinformatics, Fudan University Center for Clinical Bioinformatics, Shanghai, China. Electronic address: xiangdong.wang@clintransmed.org.
authors: Xiangdong
authors: X
authors: Wang
mesh_terms: D000818:Animals; D018450:Disease Progression; D053263:Gene Regulatory Networks; D018740:Genetic Heterogeneity; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics* / Q000378:metabolism* / Q000473:pathology; D053495:Osteopontin / Q000737:chemistry / Q000378:metabolism*; D020033:Protein Isoforms / Q000378:metabolism
chemical_list: D020033:Protein Isoforms; D053495:Osteopontin
keywords: Heterogeneity; Isoform; Lung cancer; Metastasis; Osteopontin