title: Knockout of arsenic (+3 oxidation state) methyltransferase results in sex-dependent changes in phosphatidylcholine metabolism in mice.
abstract: Arsenic (+3 oxidation state) methyltransferase is the key enzyme in the methylation pathway for inorganic arsenic. We have recently shown that As3mt knockout (KO) has a profound effect on metabolomic profiles in mice. Phosphatidylcholine species (PCs) were the largest group of metabolites altered in both plasma and urine. The present study used targeted analysis to investigate the KO-associated changes in PC profiles in the liver, the site of PC synthesis. Results show that As3mt KO has a systemic effect on PC metabolism and that this effect is sex dependent.
authors: Curriculum in Toxicology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
authors: Madelyn C
authors: MC
authors: Huang
authors: Department of Nutrition, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
authors: Christelle C
authors: CC
authors: Douillet
authors: Curriculum in Toxicology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. styblo@med.unc.edu.|Department of Nutrition, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. styblo@med.unc.edu.
authors: Miroslav
authors: M
authors: Stýblo
mesh_terms: D000818:Animals; D001151:Arsenic / Q000493:pharmacokinetics / Q000633:toxicity*; D020261:Arsenic Poisoning / Q000097:blood / Q000201:enzymology* / Q000378:metabolism / Q000503:physiopathology; D018053:Arsenites / Q000008:administration & dosage; D001711:Biotransformation; D002274:Carcinogens, Environmental / Q000493:pharmacokinetics / Q000633:toxicity*; D005260:Female; D008099:Liver / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism; D008297:Male; D008745:Methylation / Q000187:drug effects; D008780:Methyltransferases / Q000235:genetics / Q000378:metabolism*; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D009369:Neoplasms / Q000097:blood / Q000139:chemically induced* / Q000209:etiology / Q000378:metabolism; D010713:Phosphatidylcholines / Q000097:blood / Q000378:metabolism*; D012727:Sex Characteristics
chemical_list: D018053:Arsenites; D002274:Carcinogens, Environmental; D010713:Phosphatidylcholines; D008780:Methyltransferases; C532135:AS3MT protein, mouse; C015001:arsenite; D001151:Arsenic
keywords: Arsenic; As3mt knockout; Liver; Mouse; Phophatidycholine; Plasma