title: Excessive gestational weight gain in the first trimester among women with normal glucose tolerance and resulting neonatal adiposity.
abstract: To assess whether weight gain above or below Institute of Medicine (IOM) recommended amounts in an ethnically diverse obstetric population with normal glucose tolerance is associated with differences in neonatal adiposity.
  
  
  
  In this prospective cohort study, healthy women with normal glucose tolerance based on the International Association of Diabetes and Pregnancy Study Groups guidelines were enrolled. Gestational weight at multiple time points were collected. Neonatal adiposity was measured by air displacement plethysmography at 24 to 72 h of life. Analyses included Fisher's exact test, analysis of variance and a trajectory analysis using a group-based weight gain trajectory model with a censored normal distribution.
  
  
  
  Overweight and obese women were more likely to exceed IOM weight gain guidelines. Regardless, there was no significant difference in %body fat of neonates born to mothers who either met or exceeded gestational weight gain (GWG) guidelines. GWG timing influenced neonatal anthropometrics: women who gained excessively by the first prenatal visit had neonates with significantly higher birth weight (3.91 vs 3.45 kg, P<0.001) and %body fat (13.7 vs 10.9%, P=0.0001) compared with women who had steady and moderate GWG.
  
  
  
  Avoidance of excessive GWG in the first trimester may prevent high amounts of neonatal adiposity.
authors: Division of Endocrinology, Ann & Robert H. Lurie Children's Hospital of Chicago, Department of Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
authors: J L
authors: JL
authors: Josefson
authors: Planned Parenthood Federation of America, New York, NY, USA.
authors: H
authors: H
authors: Simons
authors: Department of Medicine-Endocrinology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
authors: D M
authors: DM
authors: Zeiss
authors: Department of Medicine-Endocrinology, Northwestern University Feinberg School of Medicine, Chicago,IL, USA.
authors: B E
authors: BE
authors: Metzger
mesh_terms: D050154:Adiposity; D000293:Adolescent; D000328:Adult; D000704:Analysis of Variance; D001724:Birth Weight; D015992:Body Mass Index; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D017410:Practice Guidelines as Topic; D011247:Pregnancy; D011256:Pregnancy Outcome; D011261:Pregnancy Trimester, First / Q000502:physiology*; D011446:Prospective Studies; D015430:Weight Gain; D055815:Young Adult