title: Aberrant expression of MicroRNAs in B-cell lymphomas.
abstract: B-cell lymphomas represent a heterogeneous collection of more than twenty-five different malignancies. Classification is often challenging as primarily based upon, sometimes subjective, histopathological criteria and misdiagnosis can result in inappropriate treatment decisions. MicroRNAs (miRNAs) hold great promise as novel biomarkers (diagnostic, prognostic and predictive) of B-cell lymphoma in addition to being potential therapeutic targets. The most promising of these miRNAs more often than not play key regulatory roles in lymphopoiesis (development of lymphocytes) when under physiological conditions, and in the pathology of lymphoid malignancies when aberrantly expressed. In this review we consider the identity and functional role of miRNAs in the most common forms of B-cell lymphomas, their role in lymphopoiesis and their potential as biomarkers for these malignancies.
authors: Carla
authors: C
authors: Sole
authors: Erika
authors: E
authors: Larrea
authors: Lorea
authors: L
authors: Manterola
authors: Ibai
authors: I
authors: Goicoechea
authors: Maria
authors: M
authors: Armesto
authors: Maria
authors: M
authors: Arestin
authors: Maria
authors: M
authors: Caffarel
authors: Angela
authors: A
authors: Araujo
authors: Marta
authors: M
authors: Fernandez
authors: Maria
authors: M
authors: Araiz
authors: Molecular Oncology, Biodonostia Research Institute, San Sebastián, Spain.
authors: Charles
authors: C
authors: Lawrie