title: Detectability comparison of modes in dual-mode digital breast tomosynthesis.
abstract: BACKGROUND
  The objectives of this study were: (1) to evaluate the detectability of full-field digital mammography (FFDM) plus dual-mode digital breast tomosynthesis (DBT) and compare it with that of FFDM alone and (2) to compare the detectability of high-resolution-mode (HR mode used with 40°-angle imaging, 100-µm pixel size, and higher dose) DBT with that of standard-mode (ST mode used with 15°-angle imaging, 150-µm pixel size, and lower dose) DBT for diagnostic evaluation.
  
  
  METHODS
  The local Institutional Review Board approved this retrospective study of two different sets of cases. All participants gave written informed consent. FFDM and DBT images of 471 women who were recalled were acquired between August 2013 and October 2014. HR mode and ST mode were applied to 155 breasts and 157 breasts, respectively. The cases of both modes were selected randomly. Eight radiologists interpreted the images. The detectability for recall cases and for follow cases, and area under the receiver operating characteristic curve (AUC) were calculated.
  
  
  RESULTS
  Adding DBT to FFDM significantly increased the detectability for recall cases and AUC relative to those of FFDM alone (HR mode 8.9 %; 95 % confidence interval (CI) 5.7, 15.0 %; P = 0.013 and 4.9 %; 95 % CI 2.1, 7.7 %; P = 0.001; ST mode 8.3 %; 95 % CI 4.1, 12.1 %; P = 0.007 and 2.9 %; 95 % CI 0.5, 5.3 %; P = 0.02), whereas the detectability for follow cases did not significantly differ. The AUC increase was significantly higher in HR mode than in ST mode (1.5 %; 95 % CI 0.5, 3.7 %; P = 0.023).
  
  
  CONCLUSIONS
  Adding HR-mode or ST-mode DBT to FFDM significantly improved the detectability for diagnostic evaluation case.
authors: Department of Breast Surgery, National Hospital Organization Higashi Nagoya Hospital, 5-101 Umemorizaka, Meito-ku, Nagoya, Aichi, 465-8620, Japan. endot@e-nagoya.hosp.go.jp.
authors: Tokiko
authors: T
authors: Endo
authors: Department of Breast Treatment, National Hospital Organization Nagoya Medical Center, 4-1-1 Sannomaru, Naka-ku, Nagoya, Aichi, 460-0001, Japan.
authors: Takako
authors: T
authors: Morita
authors: Department of Radiology, National Hospital Organization Nagoya Medical Center, 4-1-1 Sannomaru, Naka-ku, Nagoya, Aichi, 460-0001, Japan.
authors: Mikinao
authors: M
authors: Oiwa
authors: Department of Breast Treatment, National Hospital Organization Nagoya Medical Center, 4-1-1 Sannomaru, Naka-ku, Nagoya, Aichi, 460-0001, Japan.
authors: Namiko
authors: N
authors: Suda
authors: Department of Surgery, National Hospital Organization Nagoya Medical Center, 4-1-1 Sannomaru, Naka-ku, Nagoya, Aichi, 460-0001, Japan.
authors: Yasuyuki
authors: Y
authors: Sato
authors: Department of Clinical Pathology, National Hospital Organization Nagoya Medical Center, 4-1-1 Sannomaru, Naka-ku, Nagoya, Aichi, 460-0001, Japan.
authors: Shu
authors: S
authors: Ichihara
authors: Breast Center, Kagawa Prefectural Central Hospital, 1-2-1 Asahimachi, Takamatsu, Kagawa, 760-0065, Japan.
authors: Misaki
authors: M
authors: Shiraiwa
authors: Department of Breast Treatment, National Hospital Organization Hamada Medical Center, 777-12 Asaicho, Hamada, Shimane, 697-8511, Japan.
authors: Kazuaki
authors: K
authors: Yoshikawa
authors: Department of Surgery, Tokai Central Hospital of Japan Mutual Aid Association of Public School Teachers, 4-6-2 Soharahigashijimacho, Kakamigahara, Gifu, 504-8601, Japan.
authors: Takao
authors: T
authors: Horiba
authors: Department of Breast Surgery, National Hospital Organization Higashi Nagoya Hospital, 5-101 Umemorizaka, Meito-ku, Nagoya, Aichi, 465-8620, Japan.
authors: Hirotoshi
authors: H
authors: Ogawa
authors: Department of Breast Surgery, National Hospital Organization Higashi Nagoya Hospital, 5-101 Umemorizaka, Meito-ku, Nagoya, Aichi, 465-8620, Japan.
authors: Yukie
authors: Y
authors: Hayashi
authors: Medical Systems Research and Development Center, FUJIFILM Corporation, 798 Miyanodai, Kaiseimachi, Ashigarakami-gun, Kanagawa, 258-8538, Japan.
authors: Tomonari
authors: T
authors: Sendai
authors: Medical Systems Research and Development Center, FUJIFILM Corporation, 798 Miyanodai, Kaiseimachi, Ashigarakami-gun, Kanagawa, 258-8538, Japan.
authors: Takahisa
authors: T
authors: Arai
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D019540:Area Under Curve; D001943:Breast Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology; D005260:Female; D006801:Humans; D008327:Mammography / Q000379:methods*; D008875:Middle Aged; D011897:Random Allocation; D012189:Retrospective Studies
keywords: Breast cancer; Detectability; Digital breast tomosynthesis; Full-field digital mammography