title: Colorectal Cancer with Residual Polyp of Origin: A Model of Malignant Transformation.
abstract: The majority of colorectal cancers (CRCs) arise from adenomatous polyps. In this study, we sought to present the underrecognized CRC with the residual polyp of origin (CRC RPO+) as an entity to be utilized as a model to study colorectal carcinogenesis. We identified all subjects with biopsy-proven CRC RPO+ that were evaluated over 10 years at Mayo Clinic, Rochester, MN, and compared their clinical and pathologic characteristics to CRC without remnant polyps (CRC RPO-). Overall survival and disease-free survival overlap with an equivalent hazard ratio between CRC RPO+ and RPO- cases when age, stage, and grade are adjusted. The somatic genomic profile obtained by whole genome sequencing and the gene expression profiles by RNA-seq for CRC RPO+ tumors were compared with that of age -and gender-matched CRC RPO- evaluated by The Cancer Genome Atlas. CRC RPO+ cases were more commonly found with lower-grade, earlier-stage disease than CRC RPO-. However, within the same disease stage and grade, their clinical course is very similar to that of CRC RPO-. The mutation frequencies of commonly mutated genes in CRC are similar between CRC RPO+ and RPO- cases. Likewise, gene expression patterns are indistinguishable between the RPO+ and RPO- cases. We have confirmed that CRC RPO+ is clinically and biologically similar to CRC RPO- and may be utilized as a model of the adenoma to carcinoma transition.
authors: Department of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, 55905.
authors: Brooke R
authors: BR
authors: Druliner
authors: Department of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, 55905.
authors: Shahrooz
authors: S
authors: Rashtak
authors: Biomedical Statistics and Informatics, Mayo Clinic, Rochester, MN, 55905.
authors: Xiaoyang
authors: X
authors: Ruan
authors: Biomedical Statistics and Informatics, Mayo Clinic, Rochester, MN, 55905.
authors: Taejeong
authors: T
authors: Bae
authors: Center for Individualized Medicine, Mayo Clinic, Rochester, MN, 55905.
authors: Nikolaos
authors: N
authors: Vasmatzis
authors: Biomedical Statistics and Informatics, Mayo Clinic, Rochester, MN, 55905.
authors: Daniel
authors: D
authors: O'Brien
authors: Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, 55905.
authors: Ruth
authors: R
authors: Johnson
authors: Department of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, 55905.
authors: Donna
authors: D
authors: Felmlee-Devine
authors: Department of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, 55905.
authors: Jill
authors: J
authors: Washechek-Aletto
authors: Department of Internal Medicine, University of Michigan, Ann Arbor, MI, 48109.
authors: Nivedita
authors: N
authors: Basu
authors: Biomedical Statistics and Informatics, Mayo Clinic, Rochester, MN, 55905.
authors: Hongfang
authors: H
authors: Liu
authors: Anatomic Pathology, Mayo Clinic, Rochester, MN, 55905.
authors: Thomas
authors: T
authors: Smyrk
authors: Biomedical Statistics and Informatics, Mayo Clinic, Rochester, MN, 55905.
authors: Alexej
authors: A
authors: Abyzov
authors: Department of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, 55905. Electronic address: boardman.lisa@mayo.edu.
authors: Lisa A
authors: LA
authors: Boardman