title: Prognostic Utility of Clinical Epilepsy Severity Score Versus Pretreatment Hypsarrhythmia Scoring in Children With West Syndrome.
abstract: This cross-sectional study assessed the impact of clinical epilepsy severity and pretreatment hypsarrhythmia severity on epilepsy and cognitive outcomes in treated children with West syndrome. Thirty-three children, aged 1 to 5 years, with infantile spasms were enrolled if pretreatment EEG records were available, after completion of ≥1 year of onset of spasms. Neurodevelopment was assessed by Development Profile 3 and Gross Motor Function Classification System. Epilepsy severity in the past 1 year was determined by the Early Childhood Epilepsy Severity Score (E-Chess). Kramer Global Score of hypsarrhythmia severity was computed. Kramer Global Score (≤8) and E-Chess (≤9) in the past 1 year were associated with favorable epilepsy outcome but not neurodevelopmental or motor outcome.
authors: 1 Department of Pediatrics, All India Institute of Medical Sciences, New Delhi, India.|2 Department of Pediatrics, Vardhmaan Mahavir Medical College and Safdarjang Hospital, New Delhi, India.
authors: Rachna
authors: R
authors: Sehgal
authors: 1 Department of Pediatrics, All India Institute of Medical Sciences, New Delhi, India.
authors: Sheffali
authors: S
authors: Gulati
authors: 1 Department of Pediatrics, All India Institute of Medical Sciences, New Delhi, India.
authors: Savita
authors: S
authors: Sapra
authors: 3 Department of Neurology, All India Institute of Medical Sciences, New Delhi, India.
authors: Manjari
authors: M
authors: Tripathi
authors: 4 Department of Biostatistics, All India Institute of Medical Sciences, New Delhi, India.
authors: Ravinder Mohan
authors: RM
authors: Pandey
authors: 1 Department of Pediatrics, All India Institute of Medical Sciences, New Delhi, India.
authors: Madhulika
authors: M
authors: Kabra
mesh_terms: D002675:Child, Preschool; D003072:Cognition Disorders / Q000175:diagnosis*; D003430:Cross-Sectional Studies; D002658:Developmental Disabilities / Q000175:diagnosis*; D003936:Diagnosis, Computer-Assisted / Q000379:methods*; D004569:Electroencephalography / Q000379:methods*; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D009069:Movement Disorders / Q000175:diagnosis*; D011379:Prognosis; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D012720:Severity of Illness Index; D013036:Spasms, Infantile / Q000175:diagnosis*
keywords: E-Chess; Kramer Global Score; West syndrome; epilepsy; motor; neurodevelopment; outcomes