title: Strategies in regenerative medicine for intervertebral disc repair using mesenchymal stem cells and bioscaffolds.
abstract: The intervertebral disc (IVD) is a major weight bearing structure that undergoes degenerative changes with aging limiting its ability to dissipate axial spinal loading in an efficient manner resulting in the generation of low back pain. Low back pain is a number one global musculoskeletal disorder with massive socioeconomic impact. The WHO has nominated development of mesenchymal stem cells and bioscaffolds to promote IVD repair as primary research objectives. There is a clear imperative for the development of strategies to effectively treat IVD defects. Early preclinical studies with mesenchymal stem cells in canine and ovine models have yielded impressive results in IVD repair. Combinatorial therapeutic approaches encompassing biomaterial and cell-based therapies promise significant breakthroughs in IVD repair in the near future.
authors: Raymond Purves Bone & Joint Research Laboratory, Kolling Institute Northern Sydney Local Health District, St Leonards, NSW 2065, Australia.|Sydney Medical School, Northern, The University of Sydney, Royal North Shore Hospital, St Leonards, NSW 2065, Australia.|Graduate School of Biomedical Engineering, University of New South Wales, Sydney, NSW 2052, Australia.
authors: James
authors: J
authors: Melrose
mesh_terms: D000818:Animals; D001672:Biocompatible Materials; D002454:Cell Differentiation; D006801:Humans; D055959:Intervertebral Disc Degeneration / Q000628:therapy*; D045164:Mesenchymal Stem Cell Transplantation; D059630:Mesenchymal Stem Cells / Q000166:cytology*; D044968:Regenerative Medicine; D023822:Tissue Engineering / Q000379:methods*; D014945:Wound Healing
chemical_list: D001672:Biocompatible Materials
keywords: annulus fibrosus; biological glues; bioscaffolds; cell delivery vehicles; hydrogels; intervertebral disc; mesenchymal stem cells; nucleus pulposus