title: [Influence of serum levels of vitamin D on IgE response in schoolchildren with asthma in poor communities].
abstract: Asthma is a common disease in the world and vitamin D (Vit-D) has been associated with the presence and severity of this disease.
  
  
  
  To establish the association between levels of Vit-D and IgE response in schoolchildren with asthma living in four cities in Colombia.
  
  
  
  Case-control study in 1340 schoolchildren (687 asthmatic and 653 controls) from communities in extreme poverty in Barranquilla, Cartagena, Santa Marta, and Montería. Serum concentrations of Vit-D, total IgE, and anti-Dermatophagoides farinae, Periplaneta americana, and Ascaris lumbricoides (AL) specific IgE were measured.
  
  
  
  Controls reported higher concentrations of Vit-D [61.9 ± 28.4 ng/mL] than cases [53 ± 23.3 ng / mL] (p < 0.05). Total IgE was higher in cases (p < 0.05). Only anti-AL IgE showed a clear difference: in controls, optical density was 0.27 ± 0.25; in cases, 0.22 ± 0.24 (p < 0.05). Vit-D showed differences between cases and controls in each population.
  
  
  
  An association could not be demonstrated between Vit-D deficiency and asthma, as total IgE was elevated in patients and controls. The results suggest that Vit-D influences the specif IgE response in poor asthmatic children in areas endemic for helminthiasis.
authors: Universidad del Norte, División Ciencias de la Salud, Grupo de Investigación en Inmunología y Biología Molecular, Barranquilla, Colombia. eegea@uninorte.edu.co.
authors: Eduardo
authors: E
authors: Egea
authors: Gloria
authors: G
authors: Garavito
authors: Luis
authors: L
authors: Fang
authors: Dary Luz
authors: DL
authors: Mendoza
authors: José Miguel
authors: JM
authors: Escamilla
authors: Elsie
authors: E
authors: De Los Ríos
authors: Rodolfo
authors: R
authors: Dennis
authors: Mario
authors: M
authors: Sánchez-Borges
mesh_terms: D000485:Allergens; D000818:Animals; D017164:Ascaris lumbricoides / Q000276:immunology; D001249:Asthma / Q000097:blood* / Q000276:immunology*; D016022:Case-Control Studies; D002648:Child; D003105:Colombia; D040001:Dermatophagoides farinae / Q000276:immunology; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood / Q000276:immunology*; D010526:Periplaneta / Q000276:immunology; D011204:Poverty Areas; D014807:Vitamin D / Q000097:blood*; D014808:Vitamin D Deficiency / Q000276:immunology*
chemical_list: D000485:Allergens; D014807:Vitamin D; D007073:Immunoglobulin E
keywords: Allergens; Ascaris lumbricoides; IgE; Pediatric asthma; School; Vitamin D