title: Hepatitis B Virus and Hepatitis D Virus Recurrence in Patients Undergoing Liver Transplantation for Hepatitis B Virus and Hepatitis B Virus Plus Hepatitis D Virus.
abstract: BACKGROUND
  In this study, we retrospectively analyzed the recurrence of hepatitis B virus (HBV) and hepatitis D virus (HDV) infection after liver transplantation for HBV and HBV+HDV co-infection.
  
  
  METHODS
  Data from patients infected with HBV and HBV+HDV who underwent liver transplantation between March 2003 and June 2013 at the Liver Transplantation Institute of Inonu University were analyzed retrospectively. A total of 255 patients were included in the study. Group 1 (n = 127) comprised patients who underwent liver transplantation because of HBV, and group 2 (n = 128) comprised patients who underwent liver transplantation because of HBV+HDV. A positive HDV antibody serologic test result was taken to indicate liver disease caused by HBV+HDV.
  
  
  RESULTS
  Thirteen of 255 were positive for the HBs Ag (5.1%). Nine (7.1%) and 4 (3.1%) patients were positive for the HBs Ag in groups 1 and 2, respectively (7.1%); the difference was not significant (P = .150). No HDV recurrence was detected in either group. The average time to HBs Ag seroconversion in 13 patients was 7.8 months after surgery (6.34 months in group 1 and 11.1 months in group 2).
  
  
  CONCLUSIONS
  In our study, recurrence rate of HBV after liver transplantation is not statistically different than the recurrence rate of HBV+HDV co-infection. A low recurrence rate was achieved by the prophylaxis protocol in use at our center. There is no standard protocol for prevention of HBV and HDV recurrence; therefore, we need new studies.
authors: Liver Transplantation Institute of Inonu University, Malatya, Turkey. Electronic address: dr.adil.baskiran@gmail.com.
authors: B
authors: B
authors: Adil
authors: Liver Transplantation Institute of Inonu University, Malatya, Turkey.
authors: O
authors: O
authors: Fatih
authors: Liver Transplantation Institute of Inonu University, Malatya, Turkey.
authors: I
authors: I
authors: Volkan
authors: Liver Transplantation Institute of Inonu University, Malatya, Turkey.
authors: B
authors: B
authors: Bora
authors: Liver Transplantation Institute of Inonu University, Malatya, Turkey.
authors: E
authors: E
authors: Veysel
authors: Liver Transplantation Institute of Inonu University, Malatya, Turkey.
authors: K
authors: K
authors: Koray
authors: Liver Transplantation Institute of Inonu University, Malatya, Turkey.
authors: K
authors: K
authors: Cemalettin
authors: Liver Transplantation Institute of Inonu University, Malatya, Turkey.
authors: I
authors: I
authors: Burak
authors: Liver Transplantation Institute of Inonu University, Malatya, Turkey.
authors: Y
authors: Y
authors: Sezai
mesh_terms: D000328:Adult; D060085:Coinfection / Q000453:epidemiology / Q000601:surgery; D005260:Female; D006509:Hepatitis B / Q000453:epidemiology* / Q000517:prevention & control / Q000601:surgery; D006515:Hepatitis B virus; D003699:Hepatitis D / Q000453:epidemiology* / Q000517:prevention & control / Q000601:surgery; D003698:Hepatitis Delta Virus; D006801:Humans; D016031:Liver Transplantation / Q000009:adverse effects; D008297:Male; D008875:Middle Aged; D012008:Recurrence