title: Biomarkers in Alpha-1 Antitrypsin Deficiency Chronic Obstructive Pulmonary Disease.
abstract: Biomarkers of pathogenesis in chronic obstructive pulmonary disease (COPD) can significantly accelerate drug development. In COPD related to alpha-1 antitrypsin deficiency, the role of neutrophil elastase and its inhibition by alpha-1 antitrypsin protein focused interest on elastin degradation and the development of pulmonary emphysema. Amino acids desmosine and isodesmosine are unique cross-links in mature elastin fibers and can serve as biomarkers of elastin degradation when measured in body fluids. This review gives a perspective on what has been learned by the earliest measurements of desmosine and isodesmosine followed by later studies using methods of increased sensitivity and specificity and the meaning for developing new therapies. Also included are brief statements on the biomarkers fibrinogen, CC-16, and Aa-Val-360 in COPD.
authors: 1 Mt. Sinai-St. Luke's-Roosevelt Hospital, New York, New York.|2 Mt. Sinai Icahn School of Medicine, New York, New York; and.
authors: Gerard M
authors: GM
authors: Turino
authors: 1 Mt. Sinai-St. Luke's-Roosevelt Hospital, New York, New York.|2 Mt. Sinai Icahn School of Medicine, New York, New York; and.
authors: Shuren
authors: S
authors: Ma
authors: 3 St. John's University College of Pharmacy and Health Sciences, New York, New York.
authors: Jerome O
authors: JO
authors: Cantor
authors: 1 Mt. Sinai-St. Luke's-Roosevelt Hospital, New York, New York.|2 Mt. Sinai Icahn School of Medicine, New York, New York; and.
authors: Yong Y
authors: YY
authors: Lin
mesh_terms: D015415:Biomarkers / Q000378:metabolism; D003895:Desmosine / Q000378:metabolism; D004549:Elastin / Q000378:metabolism; D005340:Fibrinogen / Q000378:metabolism; D006801:Humans; D007524:Isodesmosine / Q000378:metabolism; D019272:Leukocyte Elastase / Q000378:metabolism; D029424:Pulmonary Disease, Chronic Obstructive / Q000209:etiology / Q000378:metabolism; D011656:Pulmonary Emphysema / Q000209:etiology / Q000378:metabolism*; D014598:Uteroglobin / Q000378:metabolism; D019896:alpha 1-Antitrypsin Deficiency / Q000150:complications / Q000378:metabolism*
chemical_list: D015415:Biomarkers; C556389:SCGB1A1 protein, human; D003895:Desmosine; D005340:Fibrinogen; D004549:Elastin; D014598:Uteroglobin; D007524:Isodesmosine; D019272:Leukocyte Elastase
keywords: alpha-1 antitrypsin deficiency; biomarkers; chronic obstructive pulmonary disease; emphysema