title: Cutting Edge: IgE Plays an Active Role in Tumor Immunosurveillance in Mice.
abstract: Exogenous IgE acts as an adjuvant in tumor vaccination in mice, and therefore a direct role of endogenous IgE in tumor immunosurveillance was investigated. By using genetically engineered mice, we found that IgE ablation rendered mice more susceptible to the growth of transplantable tumors. Conversely, a strengthened IgE response provided mice with partial or complete resistance to tumor growth, depending on the tumor type. By genetic crosses, we showed that IgE-mediated tumor protection was mostly lost in mice lacking FcεRI. Tumor protection was also lost after depletion of CD8(+) T cells, highlighting a cross-talk between IgE and T cell-mediated tumor immunosurveillance. Our findings provide the rationale for clinical observations that relate atopy with a lower risk for developing cancer and open new avenues for the design of immunotherapeutics relevant for clinical oncology.
authors: Division of Genetics and Cell Biology, IRCCS, San Raffaele Scientific Institute, 20132 Milan, Italy;
authors: Elisa A
authors: 0000-0002-5806-9495
authors: EA
authors: Nigro
authors: Dipartimento di Scienze Biomediche, Chirurgiche e Odontoiatriche, Università degli Studi di Milano, 20133 Milan, Italy; IRCCS, Galeazzi Orthopedic Institute, 20161 Milan, Italy;
authors: Anna T
authors: 0000-0002-7848-8099
authors: AT
authors: Brini
authors: Dipartimento di Scienze Biomediche, Chirurgiche e Odontoiatriche, Università degli Studi di Milano, 20133 Milan, Italy;
authors: Vijay A
authors: 0000-0002-7480-8518
authors: VA
authors: Yenagi
authors: Dipartimento di Scienze Biomediche, Chirurgiche e Odontoiatriche, Università degli Studi di Milano, 20133 Milan, Italy;
authors: Lorena M
authors: 0000-0002-4262-0406
authors: LM
authors: Ferreira
authors: Department of Molecular Biology, Christian Doppler Laboratory for Allergy Diagnosis and Therapy, University of Salzburg, 5020 Salzburg, Austria;
authors: Gertrude
authors: 0000-0002-1817-7870
authors: G
authors: Achatz-Straussberger
authors: Vita-Salute San Raffaele University, 20132 Milan, Italy;
authors: Alessandro
authors: 0000-0003-1976-5663
authors: A
authors: Ambrosi
authors: Department of Pathology, IRCCS, San Raffaele Scientific Institute, 20132 Milan, Italy;
authors: Francesca
authors: F
authors: Sanvito
authors: Division of Genetics and Cell Biology, IRCCS, San Raffaele Scientific Institute, 20132 Milan, Italy;
authors: Elisa
authors: E
authors: Soprana
authors: Division of Genetics and Cell Biology, IRCCS, San Raffaele Scientific Institute, 20132 Milan, Italy;
authors: Eelco
authors: 0000-0001-9529-2701
authors: E
authors: van Anken
authors: Department of Molecular Biology, Christian Doppler Laboratory for Allergy Diagnosis and Therapy, University of Salzburg, 5020 Salzburg, Austria;
authors: Gernot
authors: G
authors: Achatz
authors: Division of Genetics and Cell Biology, IRCCS, San Raffaele Scientific Institute, 20132 Milan, Italy;
authors: Antonio G
authors: 0000-0002-1654-5545
authors: AG
authors: Siccardi
authors: Protein Engineering and Therapeutics Unit, Division of Immunology, Transplantation, and Infectious Diseases, IRCCS, San Raffaele Scientific Institute, 20132 Milan, Italy; and Department of Biomedical Sciences, Nazarbayev University School of Medicine, 010000 Astana, Kazakhstan luca.vangelista@nu.edu.kz.
authors: Luca
authors: 0000-0003-0764-5031
authors: L
authors: Vangelista
mesh_terms: D000276:Adjuvants, Immunologic; D000818:Animals; D005818:Genetic Engineering; D007073:Immunoglobulin E / Q000276:immunology*; D007157:Immunologic Surveillance / Q000276:immunology*; D007167:Immunotherapy; D051379:Mice; D008807:Mice, Inbred BALB C; D018345:Mice, Knockout; D009369:Neoplasms / Q000235:genetics / Q000276:immunology* / Q000473:pathology / Q000628:therapy; D017455:Receptors, IgE / Q000172:deficiency / Q000276:immunology*
chemical_list: D000276:Adjuvants, Immunologic; D017455:Receptors, IgE; D007073:Immunoglobulin E