title: Management of the risks for inherited disease in donor-conceived offspring.
abstract: OBJECTIVE
  To illustrate the burden of inherited disease on donor-conceived offspring based on mode of inheritance and to provide guidance on methods of risk reduction.
  
  
  METHODS
  An 8.5-year retrospective review of outcome reports and donor management to summarize medical risks to donor-conceived offspring that presented after the sperm donors were qualified for participation in the donor program.
  
  
  METHODS
  Not applicable.
  
  
  METHODS
  None.
  
  
  METHODS
  None.
  
  
  METHODS
  Description of our experience with newly identified medical risks in donor-conceived offspring as well as how this information was ascertained and managed.
  
  
  RESULTS
  More than half of the indications to restrict donor specimen distribution were due to multifactorial disorders. Approximately one third of the restrictions involved autosomal recessive disorders. The remainder of the restrictions were due to the other indications, including autosomal dominant disorders.
  
  
  CONCLUSIONS
  The risks for multifactorial disorders or undiagnosed autosomal dominant disease cannot be significantly reduced or eliminated with routine donor screening procedures. Ongoing risk assessment is essential to identify new genetic risks for autosomal dominant and multifactorial disorders. These assessments require an investment of resources and genetics professionals in the long-term management of changing health information as well as collaboration among gamete facilities, recipients, donors, and their health care providers.
authors: California Cryobank, Los Angeles, California.
authors: Lauren
authors: L
authors: Isley
authors: Cedars-Sinai Medical Center, Los Angeles, California.
authors: Rena E
authors: RE
authors: Falk
authors: California Cryobank, Los Angeles, California.
authors: Jaime
authors: J
authors: Shamonki
authors: California Cryobank, Los Angeles, California.
authors: Charles A
authors: CA
authors: Sims
authors: California Cryobank, Los Angeles, California. Electronic address: pcallum@cryobank.com.
authors: Pamela
authors: P
authors: Callum
mesh_terms: D005260:Female; D030342:Genetic Diseases, Inborn / Q000175:diagnosis / Q000235:genetics* / Q000517:prevention & control*; D020022:Genetic Predisposition to Disease; D005820:Genetic Testing; D040941:Heredity; D006579:Heterozygote; D006801:Humans; D019520:Living Donors; D008297:Male; D010375:Pedigree; D011247:Pregnancy; D027724:Reproductive Techniques, Assisted / Q000009:adverse effects*; D012189:Retrospective Studies; D018570:Risk Assessment; D012307:Risk Factors; D012308:Risk Management; D012661:Semen; D013074:Sperm Banks; D016896:Treatment Outcome; D061349:Unrelated Donors
keywords: Gamete donor; autosomal dominant; autosomal recessive; multifactorial; sperm donor