title: The CYP19A1 rs3751592 variant confers susceptibility to Alzheimer disease in the Chinese Han population.
abstract: BACKGROUND
  The CYP19A1 enzyme (aromatase) encoded by the cytochrome P450 (CYP) 19A1 gene influences the final step in the biosynthesis of estrogen, which has been associated with Alzheimer disease (AD). It is possible that genetic polymorphisms in CYP19A1 could influence the risk of AD by altering the expression of CYP19A1. The ε4 allele of the apolipoprotein E (APOE) gene, which is the most significant known genetic risk factor for AD, may mask the effects of other loci.
  
  
  METHODS
  To assess the potential association of CYP19A1 gene polymorphisms with the risk of AD, we conducted a case-control study in a Chinese Han population by recruiting 463 cases, including 207 patients diagnosed with AD and 256 healthy people matched for sex and age.
  
  
  RESULTS
  In APOE ε4 carriers, the distributions of the G allele and the AG + GG genotype of CYP19A1 rs3751592 in patients differed significantly (P < 0.05) from those in healthy people. However, no difference was observed in the distribution of CYP19A1 rs1065778 between the patient and control populations, regardless of their APOE ε4 status.
  
  
  CONCLUSIONS
  The results demonstrated that the rs3751592 A/G polymorphism of the CYP19A1 gene was associated with the incidence of AD in a Chinese Han population, which suggests that CYP19A1 rs3751592 is a predisposing genetic factor for AD.
authors: Southern Medical University Department of Pharmacy, Guangzhou General Hospital of Guangzhou Military Command Center for Disease Control and Prevention of Guangzhou Military Command, Guangzhou, China.
authors: Jiaqiang
authors: J
authors: Zheng
authors: Huacheng
authors: H
authors: Yan
authors: Lei
authors: L
authors: Shi
authors: Yanying
authors: Y
authors: Kong
authors: Yongpan
authors: Y
authors: Zhao
authors: Li
authors: L
authors: Xie
authors: Jian
authors: J
authors: Li
authors: Mukun
authors: M
authors: Huang
authors: Jin
authors: J
authors: Li
authors: Shujin
authors: S
authors: Zhao
mesh_terms: D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000235:genetics*; D053327:Apolipoprotein E4 / Q000235:genetics; D001141:Aromatase / Q000235:genetics*; D044466:Asian People / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D020641:Polymorphism, Single Nucleotide
chemical_list: D053327:Apolipoprotein E4; D001141:Aromatase; C561410:CYP19A1 protein, human