title: [Heparin-induced thrombocytopenia. New therapeutical options].
abstract: Heparin-induced thrombocytopenia (HIT) is an immune-mediated adverse reaction due to antibodies to a multimolecular complex of heparin and platelet factor 4 (PF4) characterized by moderate thrombocytopenia and paradoxical arterial or venous thrombosis. It is a relatively infrequent complication related to the administration of any type of heparin. In patients undergoing percutaneous coronary revascularization or coronary artery by-pass graft the prevalence of HIT is higher than in other clinical settings. Recognizing clinical and laboratory features of HIT allow immediate discontinuation of heparin and the use of alternative anticoagulants to avoid serious thrombotic complications. In this review, we summarize different therapeutic options for the treatment of HIT with special emphasis on direct oral anticoagulants (DOACS) such as dabigatran, rivaroxaban and apixaban. DOACS might represent a therapeutic alternative for HIT treatment.
authors: Servicio de Clínica Médica, Hospital Privado Centro Médico de Córdoba, Córdoba, Argentina. E-mail: cari_seculini@hotmail.com.
authors: Carina E
authors: CE
authors: Seculini Patiño
authors: Servicio de Medicina Vascular y Trombosis, Hospital Privado Centro Médico de Córdoba, Córdoba, Argentina.
authors: Aldo H
authors: AH
authors: Tabares
mesh_terms: D000925:Anticoagulants / Q000009:adverse effects* / Q000276:immunology / Q000627:therapeutic use*; D000991:Antithrombins / Q000627:therapeutic use*; D006493:Heparin / Q000009:adverse effects* / Q000276:immunology; D006801:Humans; D010978:Platelet Factor 4 / Q000276:immunology; D013921:Thrombocytopenia / Q000139:chemically induced* / Q000188:drug therapy* / Q000276:immunology; D013927:Thrombosis / Q000517:prevention & control*; D020246:Venous Thrombosis / Q000517:prevention & control
chemical_list: D000925:Anticoagulants; D000991:Antithrombins; D010978:Platelet Factor 4; D006493:Heparin
keywords: direct oral anticoagulants; heparin induced thrombocytopenia; thrombosis