title: When MFN2 (mitofusin 2) met autophagy: A new age for old muscles.
abstract: A long-standing quest is to define the mechanisms responsible for the mitochondrial dysfunction and accumulation of damaged mitochondria that occur during aging. Indeed, those defects are considered major contributors to the aging process. We have analyzed the effect of aging on the muscle expression of Mfn2 and the impact of Mfn2 ablation on muscle function. Our findings reveal that Mfn2 is repressed in muscle during aging, and that is a determinant for the inhibition of autophagy, and mitochondrial quality control, which lead to the accumulation of damaged mitochondria.
authors: a Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology , Barcelona , Spain.|b Departament de Bioquímica i Biomedicina Molecular , Facultat de Biologia , Universitat de Barcelona , Barcelona , Spain.|c Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Instituto de Salud Carlos III , Madrid , Spain.
authors: David
authors: D
authors: Sebastián
authors: a Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology , Barcelona , Spain.|b Departament de Bioquímica i Biomedicina Molecular , Facultat de Biologia , Universitat de Barcelona , Barcelona , Spain.|c Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Instituto de Salud Carlos III , Madrid , Spain.
authors: Antonio
authors: A
authors: Zorzano
mesh_terms: D000375:Aging / Q000473:pathology*; D000818:Animals; D001343:Autophagy; D006801:Humans; D051379:Mice; D024101:Mitochondrial Proteins / Q000378:metabolism*; D008954:Models, Biological; D009132:Muscles / Q000378:metabolism* / Q000473:pathology*
chemical_list: D024101:Mitochondrial Proteins
keywords: aging; mitochondria; mitophagy; muscle; sarcopenia