title: The weeks and the cumulative doses of the first adverse events related to oral isotretinoin in acne patients: analysis of 300 patients.
abstract: BACKGROUND
  The purpose of our study is to find out in which weeks and in which cumulative doses the side effects emerge and to study whether or not there is a significant variance between the observed period and doses of the emergent side effects of the patients taking the daily doses of below and above 0.5 mg/kg.
  
  
  METHODS
  Patients were started treatment with doses of 0.25-1 mg/kg isotretinoin, and a form was given to the patients to mark which probable side effects occurred in which weeks and called for weekly follow-up for the first 2 months.
  
  
  RESULTS
  The median of the complaints of emerged side effects such as chellitis, dry face and facial erythema, photobia and nyctalopia was in less than 4 weeks. When the doses taken below and above 0.5 mg/kg are compared, the side effects observed to have differences between both the week they occurred and the cumulative doses are xerosis, dry face, exacerbation of acnes, nervousness, and somnolence.
  
  
  CONCLUSIONS
  We believe that knowing which weeks the side effects are observed first, warning about the side effects that may especially occur in the first 4 weeks, and ensuring some measures are taken before the side effects are observed will increase the success of patient compatibility and management of side effects.
authors: a Department of Dermatology , Ataturk Training and Research Hospital , Ankara , Turkey.
authors: Duriye Deniz
authors: DD
authors: Demirseren
authors: a Department of Dermatology , Ataturk Training and Research Hospital , Ankara , Turkey.
authors: Fadime
authors: F
authors: Kilinc
authors: a Department of Dermatology , Ataturk Training and Research Hospital , Ankara , Turkey.
authors: Selma
authors: S
authors: Emre
authors: b Biostatistics and Medical Informatic , Yildirim Beyazit University, Faculty of Medicine , Ankara , Turkey.
authors: Mesut
authors: M
authors: Akyol
authors: a Department of Dermatology , Ataturk Training and Research Hospital , Ankara , Turkey.
authors: Ahmet
authors: A
authors: Metin
authors: a Department of Dermatology , Ataturk Training and Research Hospital , Ankara , Turkey.
authors: Akin
authors: A
authors: Aktas
mesh_terms: D000152:Acne Vulgaris / Q000188:drug therapy*; D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D004890:Erythema / Q000209:etiology*; D005145:Face / Q000503:physiopathology; D005260:Female; D006801:Humans; D015474:Isotretinoin / Q000009:adverse effects* / Q000627:therapeutic use; D008297:Male; D009755:Night Blindness / Q000209:etiology; D055815:Young Adult
chemical_list: D015474:Isotretinoin
keywords: Acne vulgaris; adverse events; isotretinoin; side effect