title: Stability of folic acid under several parameters.
abstract: Folic acid is a small molecule, also known as vitamin B9. It is an essential compound involved in important biochemical processes. It is widely used as a vector for targeted treatment and diagnosis especially in cancer therapeutics. Nevertheless, not many authors address the problem of folic acid degradation. Several researchers reported their observations concerning its denaturation, but they generally only took into account one parameter (pH, temperature, light or O2etc.). In this review, we will focus on five main parameters (assessed individually or in conjunction with one or several others) that have to be taken into account to avoid the degradation of folic acid: light, temperature, concentration, oxygen and pH, which are the most cited in the literature. Scrupulous bibliographic research enabled us to determine two additional degradation factors that are the influence of singlet oxygen and electron beam on folic acid stability, which are not considered as among the prime factors. Although these two factors are not commonly present as compared to the others, singlet oxygen and electron beams intervene in new therapeutic technologies and must be taken in consideration for further applications such photodynamic or X-rays therapies.
authors: Laboratoire de Chimie Physique macromoléculaire, UMR-CNRS 7375, Lorraine-Université, 1 rue Grandville, BP451, 54001 Nancy Cedex, France; Universiti Sains Malaysia, Penang 11800, Malaysia.
authors: Amirah Mohd
authors: AM
authors: Gazzali
authors: Laboratoire Réactions et Génie des Procédés, UMR-CNRS 7274, Lorraine-Université, 1 rue Grandville, BP451, 54001 Nancy Cedex, France.
authors: Mathilde
authors: M
authors: Lobry
authors: Laboratoire Réactions et Génie des Procédés, UMR-CNRS 7274, Lorraine-Université, 1 rue Grandville, BP451, 54001 Nancy Cedex, France.
authors: Ludovic
authors: L
authors: Colombeau
authors: Laboratoire de Chimie Physique macromoléculaire, UMR-CNRS 7375, Lorraine-Université, 1 rue Grandville, BP451, 54001 Nancy Cedex, France.
authors: Samir
authors: S
authors: Acherar
authors: Université de Lille, INSERM, CHU Lille, U1189 - ONCO-THAI - Image Assisted Laser Therapy for Oncology, F-59000 Lille, France.
authors: Henri
authors: H
authors: Azaïs
authors: Université de Lille, INSERM, CHU Lille, U1189 - ONCO-THAI - Image Assisted Laser Therapy for Oncology, F-59000 Lille, France.
authors: Serge
authors: S
authors: Mordon
authors: Laboratoire Réactions et Génie des Procédés, UMR-CNRS 7274, Lorraine-Université, 1 rue Grandville, BP451, 54001 Nancy Cedex, France.
authors: Philippe
authors: P
authors: Arnoux
authors: Laboratoire Réactions et Génie des Procédés, UMR-CNRS 7274, Lorraine-Université, 1 rue Grandville, BP451, 54001 Nancy Cedex, France.
authors: Francis
authors: F
authors: Baros
authors: Laboratoire de Chimie Physique macromoléculaire, UMR-CNRS 7375, Lorraine-Université, 1 rue Grandville, BP451, 54001 Nancy Cedex, France.
authors: Régis
authors: R
authors: Vanderesse
authors: Laboratoire Réactions et Génie des Procédés, UMR-CNRS 7274, Lorraine-Université, 1 rue Grandville, BP451, 54001 Nancy Cedex, France. Electronic address: celine.frochot@univ-lorraine.fr.
authors: Céline
authors: C
authors: Frochot
mesh_terms: D004355:Drug Stability; D005492:Folic Acid / Q000737:chemistry* / Q000528:radiation effects; D006863:Hydrogen-Ion Concentration; D010100:Oxygen / Q000737:chemistry; D013696:Temperature; D014466:Ultraviolet Rays
chemical_list: D005492:Folic Acid; D010100:Oxygen
keywords: 6-Formylpterin (PubChem CID: 150847); Folic acid (PubChem CID: 6037); Folic acid degradation; Glutamic acid (PubChem CID: 33032); PABA (PubChem CID: 978); Photolysis; Pterin; Pterin (PubChem CID: 73000); Pterin-6-carboxylic acid (PubChem CID: 70361); Xanthopterin (PubChem CID: 8397); p-Aminobenzoic acid; p-Aminobenzoyl-l-glutamic acid; p-Aminobenzoyl-l-glutamic acid (PubChem CID: 196473); pH