title: Three-Dimensional Clustered Nanostructures for Microfluidic Surface-Enhanced Raman Detection.
abstract: A materials fabrication concept based on a fluid-construction strategy to create three-dimensional (3D) ZnO@ZnS-Ag active nanostructures at arbitrary position within confined microchannels to form an integrated microfluidic surface-enhanced Raman spectroscopy (SERS) system is presented. The fluid-construction process allowed facile construction of the nanostructured substrates, which were shown to possess a substantial number of integrated hot spots that support SERS activity. Finite-difference time-domain (FDTD) analysis suggested that the 3D clustered geometry facilitated hot spot formation. High sensitivity and good recycle performance were demonstrated using 4-mercaptobenzoic acid (4-MBA) and a mixture of Rhodamine 6G (R6G) and 4-MBA as target organic pollutants to evaluate the SERS microfluidic device performance. The 3D clustered nanostructures were also effective in the detection of a representative nerve agent and biomolecule. The results of this investigation provide a materials and process approach to the fabrication of requisite nanostructures for the online detection of organic pollutants, devices for real-time observation of environmental hazards, and personal-health monitoring.
authors: State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Materials Science and Engineering, Donghua University , Shanghai 201602, People's Republic of China.|School of Chemical and Biomolecular Engineering, School of Chemistry and Biochemistry, School of Materials Science and Engineering, Georgia Institute of Technology , Atlanta, Georgia 30332, United States.
authors: Gang
authors: G
authors: Wang
authors: State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Materials Science and Engineering, Donghua University , Shanghai 201602, People's Republic of China.
authors: Kerui
authors: K
authors: Li
authors: Francis J
authors: FJ
authors: Purcell
authors: State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Materials Science and Engineering, Donghua University , Shanghai 201602, People's Republic of China.
authors: De
authors: D
authors: Zhao
authors: State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Materials Science and Engineering, Donghua University , Shanghai 201602, People's Republic of China.
authors: Wei
authors: W
authors: Zhang
authors: State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Materials Science and Engineering, Donghua University , Shanghai 201602, People's Republic of China.
authors: Zhongyuan
authors: Z
authors: He
authors: School of Chemical and Biomolecular Engineering, School of Chemistry and Biochemistry, School of Materials Science and Engineering, Georgia Institute of Technology , Atlanta, Georgia 30332, United States.
authors: Shuai
authors: S
authors: Tan
authors: School of Chemical and Biomolecular Engineering, School of Chemistry and Biochemistry, School of Materials Science and Engineering, Georgia Institute of Technology , Atlanta, Georgia 30332, United States.
authors: Zhenguan
authors: Z
authors: Tang
authors: State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Materials Science and Engineering, Donghua University , Shanghai 201602, People's Republic of China.
authors: Hongzhi
authors: H
authors: Wang
authors: School of Chemical and Biomolecular Engineering, School of Chemistry and Biochemistry, School of Materials Science and Engineering, Georgia Institute of Technology , Atlanta, Georgia 30332, United States.
authors: Elsa
authors: E
authors: Reichmanis
keywords: SERS detection; biomolecule detection; clustered nanostructures; fluid construction; microfluidic technology