title: Boosted Hyperthermia Therapy by Combined AC Magnetic and Photothermal Exposures in Ag/Fe3O4 Nanoflowers.
abstract: Over the past two decades, magnetic hyperthermia and photothermal therapy are becoming very promising supplementary techniques to well-established cancer treatments such as radiotherapy and chemotherapy. These techniques have dramatically improved their ability to perform controlled treatments, relying on the procedure of delivering nanoscale objects into targeted tumor tissues, which can release therapeutic killing doses of heat either upon AC magnetic field exposure or laser irradiation. Although an intense research effort has been made in recent years to study, separately, magnetic hyperthermia using iron oxide nanoparticles and photothermal therapy based on gold or silver plasmonic nanostructures, the full potential of combining both techniques has not yet been systematically explored. Here we present a proof-of-principle experiment showing that designing multifunctional silver/magnetite (Ag/Fe3O4) nanoflowers acting as dual hyperthermia agents is an efficient route for enhancing their heating ability or specific absorption rate (SAR). Interestingly, the SAR of the nanoflowers is increased by at least 1 order of magnitude under the application of both an external magnetic field of 200 Oe and simultaneous laser irradiation. Furthermore, our results show that the synergistic exploitation of the magnetic and photothermal properties of the nanoflowers reduces the magnetic field and laser intensities that would be required in the case that both external stimuli were applied separately. This constitutes a key step toward optimizing the hyperthermia therapy through a combined multifunctional magnetic and photothermal treatment and improving our understanding of the therapeutic process to specific applications that will entail coordinated efforts in physics, engineering, biology, and medicine.
authors: Department of Physics, University of South Florida , Tampa, Florida 33620, United States.
authors: R
authors: R
authors: Das
authors: Department of Physics, University of South Florida , Tampa, Florida 33620, United States.|Departamento de Física, Universidad de Oviedo , Oviedo E-33007, Spain.
authors: N
authors: N
authors: Rinaldi-Montes
authors: Department of Physics, University of South Florida , Tampa, Florida 33620, United States.|BCMaterials Edificio No. 500, Parque Tecnológico de Vizcaya , Derio 48160, Spain.
authors: J
authors: J
authors: Alonso
authors: Servicios Científico-Técnicos, Universidad de Oviedo , Oviedo E-33006, Spain.
authors: Z
authors: Z
authors: Amghouz
authors: Department of Electricity and Electronics, University of Basque Country (UPV/EHU) , Leoia 48940, Spain.
authors: E
authors: E
authors: Garaio
authors: BCMaterials Edificio No. 500, Parque Tecnológico de Vizcaya , Derio 48160, Spain.|Department of Applied Physics II, University of Basque Country (UPV/EHU) , Leoia 48940, Spain.
authors: J A
authors: JA
authors: García
authors: Departamento de Física & IUTA, EPI, Universidad de Oviedo , Gijón E-33203, Spain.
authors: P
authors: P
authors: Gorria
authors: Departamento de Física, Universidad de Oviedo , Oviedo E-33007, Spain.
authors: J A
authors: JA
authors: Blanco
authors: Department of Physics, University of South Florida , Tampa, Florida 33620, United States.
authors: M H
authors: MH
authors: Phan
authors: Department of Physics, University of South Florida , Tampa, Florida 33620, United States.
authors: H
authors: H
authors: Srikanth
mesh_terms: D005290:Ferric Compounds; D006046:Gold; D006979:Hyperthermia, Induced; D060526:Magnetic Fields; D008280:Magnetics; D058185:Magnetite Nanoparticles; D049329:Nanostructures
chemical_list: D005290:Ferric Compounds; D058185:Magnetite Nanoparticles; C000499:ferric oxide; D006046:Gold
keywords: bifunctional nanoparticles; hyperthermia; magneto-thermal effect; nanoflowers; photothermal effect