title: Route to Highly Substituted Pyridines.
abstract: Pyridine rings are common structural motifs found in a number of biologically active compounds, including some top-selling pharmaceuticals. We have developed a new approach to access substituted pyridines. The method aims to provide a reliable synthesis of a diverse range of substituted pyridines through a three-step procedure. Readily available enones are first converted into 1,5-dicarbonyls through a two-step Hosomi-Sakurai allylation/oxidative cleavage sequence, which is followed by subsequent cyclization to the corresponding pyridine using hydroxylamine hydrochloride. A variety of substituted pyridines have been synthesized using this method.
authors: Department of Chemistry, University of California, Irvine , 1102 Natural Sciences II, Irvine, California 92697, United States.
authors: Justin A
authors: JA
authors: Hilf
authors: Department of Chemistry, University of California, Irvine , 1102 Natural Sciences II, Irvine, California 92697, United States.
authors: Michael S
authors: MS
authors: Holzwarth
authors: Department of Chemistry, University of California, Irvine , 1102 Natural Sciences II, Irvine, California 92697, United States.
authors: Scott D
authors: SD
authors: Rychnovsky