title: Advanced soft-tissue sarcoma and treatment options: critical appraisal of trabectedin.
abstract: Soft-tissue sarcomas (STS) are a heterogeneous group of rare solid tumors of mesenchymal origin. This paper reviews the current status of systemic treatment in advanced and metastatic soft tissue sarcomas, with an emphasis on trabectedin. Trabectedin is a unique type of chemotherapeutic agent with multiple potential mechanisms of action. We discuss the putative mechanisms, as well as the toxicity and administration schedules of trabectedin, followed by its efficacy in first-line systemic therapy and beyond first-line systemic therapy.
authors: Department of Medical Oncology, Radboud University Medical Center, Nijmegen, the Netherlands.
authors: Ingrid M E
authors: IM
authors: Desar
authors: The Institute of Cancer Research and the Royal Marsden NHS Foundation Trust, London, UK.
authors: Anastasia
authors: A
authors: Constantinidou
authors: Department of Medical Oncology, Radboud University Medical Center, Nijmegen, the Netherlands.
authors: Suzanne E J
authors: SE
authors: Kaal
authors: The Institute of Cancer Research and the Royal Marsden NHS Foundation Trust, London, UK.
authors: Robin L
authors: RL
authors: Jones
authors: Department of Medical Oncology, Radboud University Medical Center, Nijmegen, the Netherlands; The Institute of Cancer Research and the Royal Marsden NHS Foundation Trust, London, UK.
authors: Winette T A
authors: WT
authors: van der Graaf
keywords: chemotherapy; soft-tissue sarcoma; trabectedin