title: CD26 and Asthma: a Comprehensive Review.
abstract: Asthma is a heterogeneous and chronic inflammatory family of disorders of the airways with increasing prevalence that results in recurrent and reversible bronchial obstruction and expiratory airflow limitation. These diseases arise from the interaction between environmental and genetic factors, which collaborate to cause increased susceptibility and severity. Many asthma susceptibility genes are linked to the immune system or encode enzymes like metalloproteases (e.g., ADAM-33) or serine proteases. The S9 family of serine proteases (prolyl oligopeptidases) is capable to process peptide bonds adjacent to proline, a kind of cleavage-resistant peptide bonds present in many growth factors, chemokines or cytokines that are important for asthma. Curiously, two serine proteases within the S9 family encoded by genes located on chromosome 2 appear to have a role in asthma: CD26/dipeptidyl peptidase 4 (DPP4) and DPP10. The aim of this review is to summarize the current knowledge about CD26 and to provide a structured overview of the numerous functions and implications that this versatile enzyme could have in this disease, especially after the detection of some secondary effects (e.g., viral nasopharyngitis) in type II diabetes mellitus patients (a subset with a certain risk of developing obesity-related asthma) upon CD26 inhibitory therapy.
authors: Department of Biochemistry and Molecular Biology, Faculty of Biology-Biological Research Centre (CIBUS), University of Santiago de Compostela (USC), Santiago de Compostela, Spain.
authors: Juan J
authors: JJ
authors: Nieto-Fontarigo
authors: Department of Biochemistry and Molecular Biology, Faculty of Biology-Biological Research Centre (CIBUS), University of Santiago de Compostela (USC), Santiago de Compostela, Spain.|Respiratory Department, Clinic University Hospital (CHUS), Santiago de Compostela, Spain.
authors: Francisco J
authors: FJ
authors: González-Barcala
authors: Clinical Analysis Service, Clinic University Hospital (CHUS), Santiago de Compostela, Spain.
authors: Esther
authors: E
authors: San José
authors: Department of Biochemistry and Molecular Biology, Faculty of Biology-Biological Research Centre (CIBUS), University of Santiago de Compostela (USC), Santiago de Compostela, Spain.
authors: Pilar
authors: P
authors: Arias
authors: Department of Biochemistry and Molecular Biology, Faculty of Biology-Biological Research Centre (CIBUS), University of Santiago de Compostela (USC), Santiago de Compostela, Spain.
authors: Montserrat
authors: M
authors: Nogueira
authors: Department of Biochemistry and Molecular Biology, Faculty of Biology-Biological Research Centre (CIBUS), University of Santiago de Compostela (USC), Santiago de Compostela, Spain. franciscojavier.salgado@usc.es.
authors: Francisco J
authors: FJ
authors: Salgado
mesh_terms: D000818:Animals; D001249:Asthma / Q000175:diagnosis / Q000209:etiology* / Q000378:metabolism* / Q000628:therapy; D015415:Biomarkers; D001826:Body Fluids / Q000378:metabolism; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology / Q000378:metabolism; D018925:Chemokines / Q000378:metabolism; D016207:Cytokines / Q000378:metabolism; D018819:Dipeptidyl Peptidase 4 / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D004195:Disease Models, Animal; D020022:Genetic Predisposition to Disease; D006801:Humans; D005810:Multigene Family; D010641:Phenotype; D000085822:Prolyl Oligopeptidases; D012697:Serine Endopeptidases / Q000235:genetics / Q000378:metabolism; D012720:Severity of Illness Index; D013329:Structure-Activity Relationship; D016176:T-Lymphocyte Subsets / Q000276:immunology / Q000378:metabolism
chemical_list: D015415:Biomarkers; D018925:Chemokines; D016207:Cytokines; D018819:Dipeptidyl Peptidase 4; D012697:Serine Endopeptidases; C000705287:PREPL protein, human; D000085822:Prolyl Oligopeptidases
keywords: Asthma; CD26; CD26 inhibitors; Cytokines and chemokines; DPP4; sCD26