title: Myricitrin induces antidepressant-like effects and facilitates adult neurogenesis in mice.
abstract: Myricitrin (MYR) is a natural flavonoid that inhibits nitric oxide (NO) transmission and has an atypical antipsychotic-like profile in animal models. Considering that several NO inhibitors exert antidepressant-like effects, the present study evaluated the antidepressant-like effect of MYR (3-30mg/kg) in the tail suspension test (TST). Because of the putative relationship between adult neurogenesis and antidepressant activity, we also assessed cell proliferation, survival, and differentiation in adult neurogenic niches, including the subgranular zone (SGZ) and subventricular zone (SVZ). Similar to the positive control imipramine (IMI; 10mg/kg), repeated treatment with 10mg/kg MIR but not acute treatment reduced immobility time in the TST, indicating an antidepressant-like effect. No effect on general motor activity was observed. Myricitrin also facilitated cell proliferation in the SGZ of the hippocampal dentate gyrus and SVZ. In the SGZ, MYR increased the number of doublecortin- and 5-bromo-2'-deoxyuridine/neuronal nuclei-positive cells. Our results suggest that MYR facilitates hippocampal neurogenesis, which might contribute to its antidepressant-like effect and atypical antipsychotic-like profile.
authors: Department of Pharmacology and Therapeutics, State University of Maringá, Av. Colombo, 5790, Maringá, Paraná, Brazil.
authors: Erika
authors: E
authors: Meyer
authors: Department of Pharmacology and Therapeutics, State University of Maringá, Av. Colombo, 5790, Maringá, Paraná, Brazil.
authors: Marco Aurélio
authors: MA
authors: Mori
authors: Department of Pharmacology, Federal University of Paraná, Curitiba, Paraná, Brazil.
authors: Alline Cristina
authors: AC
authors: Campos
authors: Department of Pharmacology, Faculty of Medicine, University of São Paulo, Ribeirão Preto, São Paulo, Brazil.
authors: Roberto
authors: R
authors: Andreatini
authors: Department of Pharmacology, Federal University of Paraná, Curitiba, Paraná, Brazil.
authors: Francisco Silveira
authors: FS
authors: Guimarães
authors: Department of Pharmacology and Therapeutics, State University of Maringá, Av. Colombo, 5790, Maringá, Paraná, Brazil.
authors: Humberto
authors: H
authors: Milani
authors: Department of Pharmacology and Therapeutics, State University of Maringá, Av. Colombo, 5790, Maringá, Paraná, Brazil. Electronic address: rubiaweffort@gmail.com.
authors: Rúbia Maria Weffort
authors: RM
authors: de Oliveira
mesh_terms: D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology*; D001973:Bromodeoxyuridine / Q000378:metabolism; D018891:Dentate Gyrus / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D000089622:Doublecortin Domain Proteins; D005106:Exploratory Behavior / Q000187:drug effects; D005419:Flavonoids / Q000494:pharmacology*; D005904:Glial Fibrillary Acidic Protein / Q000378:metabolism; D019417:Hindlimb Suspension; D019394:Ki-67 Antigen / Q000378:metabolism; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008869:Microtubule-Associated Proteins / Q000378:metabolism; D055495:Neurogenesis / Q000187:drug effects*; D009479:Neuropeptides / Q000378:metabolism; D010751:Phosphopyruvate Hydratase / Q000378:metabolism
chemical_list: D000928:Antidepressive Agents; D000089622:Doublecortin Domain Proteins; D005419:Flavonoids; D005904:Glial Fibrillary Acidic Protein; D019394:Ki-67 Antigen; D008869:Microtubule-Associated Proteins; D009479:Neuropeptides; C008577:myricitrin; D010751:Phosphopyruvate Hydratase; D001973:Bromodeoxyuridine
keywords: Antidepressant-like effect; Atypical antipsychotic; Hippocampal neurogenesis; Myricitrin