title: Arginine: New Insights into Growth Performance and Urinary Metabolomic Profiles of Rats.
abstract: Arginine regulates growth performance, nutrient metabolism and health effects, but the underlying mechanism remains unknown. This study aims to investigate the effect of dietary arginine supplementation on rat growth performance and urinary metabolome through ¹H-NMR spectroscopy. Twenty rats were randomly assigned to two groups supplemented with 0% or 1.0% l-arginine for 4 weeks. Urine samples were analyzed through NMR-based metabolomics. Arginine supplementation significantly increased the urine levels of 4-aminohippurate, acetate, creatine, creatinine, ethanolamine, formate, hippurate, homogentisate, indoxyl sulfate, and phenylacetyglycine. Conversely, arginine decreased the urine levels of acetamide, β-glucose, cirtulline, ethanol, glycine, isobutyrate, lactate, malonate, methymalonate, N-acetylglutamate, N-methylnicotinamide, and propionate. Results suggested that arginine can alter common systemic metabolic processes, including energy metabolism, amino acid metabolism, and gut microbiota metabolism. Moreover, the results also imply a possible physiological role of the metabolism in mediating the arginine supplementation-supported growth of rats.
authors: Institute of Animal Nutrition, Sichuan Agricultural University, Chengdu 611130, Sichuan, China. liugm@sicau.edu.cn.|Key Laboratory for Animal Disease-Resistance Nutrition of China Ministry of Education, Chengdu 611130, Sichuan, China. liugm@sicau.edu.cn.
authors: Guangmang
authors: G
authors: Liu
authors: Institute of Animal Nutrition, Sichuan Agricultural University, Chengdu 611130, Sichuan, China. wuxianjianqq@hotmail.com.|Key Laboratory for Animal Disease-Resistance Nutrition of China Ministry of Education, Chengdu 611130, Sichuan, China. wuxianjianqq@hotmail.com.
authors: Xianjian
authors: X
authors: Wu
authors: Institute of Animal Nutrition, Sichuan Agricultural University, Chengdu 611130, Sichuan, China. jiagang700510@163.com.|Key Laboratory for Animal Disease-Resistance Nutrition of China Ministry of Education, Chengdu 611130, Sichuan, China. jiagang700510@163.com.
authors: Gang
authors: G
authors: Jia
authors: Institute of Animal Nutrition, Sichuan Agricultural University, Chengdu 611130, Sichuan, China. xlchen@sicau.edu.cn.|Key Laboratory for Animal Disease-Resistance Nutrition of China Ministry of Education, Chengdu 611130, Sichuan, China. xlchen@sicau.edu.cn.
authors: Xiaoling
authors: X
authors: Chen
authors: Institute of Animal Nutrition, Sichuan Agricultural University, Chengdu 611130, Sichuan, China. zhua666@126.com.|Key Laboratory for Animal Disease-Resistance Nutrition of China Ministry of Education, Chengdu 611130, Sichuan, China. zhua666@126.com.
authors: Hua
authors: H
authors: Zhao
authors: Maize Research Institute, Sichuan Agricultural University, Chengdu 611130, Sichuan, China. wangj221@gmail.com.
authors: Jing
authors: J
authors: Wang
authors: Institute of Animal Nutrition, Sichuan Agricultural University, Chengdu 611130, Sichuan, China. zhuomuniao278@163.com.|Key Laboratory for Animal Disease-Resistance Nutrition of China Ministry of Education, Chengdu 611130, Sichuan, China. zhuomuniao278@163.com.
authors: Caimei
authors: C
authors: Wu
authors: Institute of Animal Nutrition, Sichuan Agricultural University, Chengdu 611130, Sichuan, China. jycai2004@aliyun.com.|Key Laboratory for Animal Disease-Resistance Nutrition of China Ministry of Education, Chengdu 611130, Sichuan, China. jycai2004@aliyun.com.
authors: Jingyi
authors: J
authors: Cai
mesh_terms: D000818:Animals; D001120:Arginine / Q000493:pharmacokinetics* / Q000494:pharmacology*; D005260:Female; D055442:Metabolome / Q000187:drug effects*; D055432:Metabolomics; D051381:Rats; D017207:Rats, Sprague-Dawley; D014556:Urine / Q000737:chemistry
chemical_list: D001120:Arginine
keywords: arginine; metabolism; metabolomic profiles; urine