title: Paget's disease with craniofacial and skeletal bone involvement.
abstract: Paget's disease is a metabolic disorder of bone caused due to defect in the remodelling process and is very common in western countries but is very rare in Asians and Africans. It was first described by a British scientist Sir James Paget in 1877. It can be monostotic or polyostotic depending on the number of bones involved. It most commonly affects older people of more than 50 years. Disease involvement can be symptomatic or asymptomatic depending on the extent of the disease process. Diagnosis of Paget's disease can be made by raised serum alkaline phosphatase levels, radiological examination and by radioisotope bone scans.
authors: Department of Oral Medicine and Radiology, Lincoln University College, Kuala Lumpur, Malaysia.
authors: Narendra Prakash
authors: NP
authors: Rai
authors: Department of Oral Medicine and Radiology, KVG Dental College and Hospital, Karnataka, India.
authors: Jayaprasad
authors: J
authors: Anekar
authors: Department of Oral Medicine and Radiology, Malabar Dental College and Research Centre, Kerala, India.
authors: Shabil Mohamed
authors: SM
authors: Mustafa
authors: Department of Oral Medicine and Radiology, College of Applied Medical Sciences, Dental Biomaterial Research Chair, King Saud University, Riyadh, Saudi Arabia.
authors: Darshan
authors: D
authors: Devang Divakar
mesh_terms: D000328:Adult; D000469:Alkaline Phosphatase / Q000097:blood; D001842:Bone and Bones / Q000473:pathology*; D019465:Craniofacial Abnormalities / Q000175:diagnosis / Q000000981:diagnostic imaging; D006801:Humans; D008297:Male; D010001:Osteitis Deformans / Q000097:blood / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology; D011877:Radionuclide Imaging; D014057:Tomography, X-Ray Computed
chemical_list: D000469:Alkaline Phosphatase