title: Polydopamine-Encapsulated Fe3O4 with an Adsorbed HSP70 Inhibitor for Improved Photothermal Inactivation of Bacteria.
abstract: Photothermal treatment, a new approach for inactivation of bacteria and pathogens that does not depend on traditional therapeutic approaches, has recently received much attention. In this study, a new type of nanoplatform (PDA@Fe3O4 + PES) was fabricated by using polydopamine (PDA, a photothermal conversion agent) to encapsulate Fe3O4 (a magnetic nanoparticle) and support 2-phenylethynesulfonamide (PES, an inhibitor of heat shock protein 70 (HSP70)). Upon near-infrared light irradiation, the increased temperature weakens π-π and hydrogen bonding interactions, and PES is released from the PDA@Fe3O4 + PES. The released PES inhibits the function of HSP70, reducing bacterial tolerance to photothermal therapy and improving the therapeutic effect against infectious bacterial pathogens. After treatment, PDA@Fe3O4 + PES can be recovered using the magnetic property of the Fe3O4 cores. Consequently, PDA@Fe3O4 + PES possesses the potential to be a recyclable photothermal agent for enhanced photothermal bacterial inactivation without causing secondary pollution.
authors: Department of Chemistry, Capital Normal University , Beijing 100048, People's Republic of China.|College of Resource Environment, Tourism, Capital Normal University , Beijing 100048, People's Republic of China.
authors: Dongdong
authors: D
authors: Liu
authors: Department of Chemistry, Capital Normal University , Beijing 100048, People's Republic of China.
authors: Liyi
authors: L
authors: Ma
authors: Department of Chemistry, Capital Normal University , Beijing 100048, People's Republic of China.
authors: Lidong
authors: L
authors: Liu
authors: Department of Chemistry, Capital Normal University , Beijing 100048, People's Republic of China.
authors: Lu
authors: L
authors: Wang
authors: Department of Chemistry, Capital Normal University , Beijing 100048, People's Republic of China.
authors: Yuxin
authors: Y
authors: Liu
authors: Department of Chemistry, Capital Normal University , Beijing 100048, People's Republic of China.
authors: Qi
authors: Q
authors: Jia
authors: Department of Chemistry, Capital Normal University , Beijing 100048, People's Republic of China.
authors: Quanwei
authors: Q
authors: Guo
authors: Department of Chemistry, Capital Normal University , Beijing 100048, People's Republic of China.
authors: Ge
authors: G
authors: Zhang
authors: Department of Chemistry, Capital Normal University , Beijing 100048, People's Republic of China.
authors: Jing
authors: J
authors: Zhou
mesh_terms: D001419:Bacteria; D007211:Indoles / Q000737:chemistry*; D010789:Phototherapy; D011108:Polymers / Q000737:chemistry*
chemical_list: D007211:Indoles; D011108:Polymers; C568283:polydopamine
keywords: HSP70 inhibitor; bacteria; magnetic nanoparticles; photothermal; polydopamine