title: Effect of Ginger Supplementation on Proinflammatory Cytokines in Older Patients with Osteoarthritis: Outcomes of a Randomized Controlled Clinical Trial.
abstract: There is limited evidence that ginger powder consumption can relieve pain and inflammation due to specific anti-inflammatory phytochemical constitutents. This study investigates the effect of ginger supplementation on proinflammatory factors in participants (n = 120) of a randomized double-blind placebo-controlled 3-month clinical trial investigating knee osteoarthritis. Patients were randomly assigned to one of two groups: the ginger group (GG) or the placebo group (PG). Administered daily for 3 months, participants in the GG intervention received capsules containing 500 mg of ginger powder, while PG participants received capsules filled with 500 mg starch. Serum samples collected at baseline and 3 months were analyzed for serum levels of tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β). At baseline, proinflammatory cytokine concentrations did not differ by group. However, at 3 months, both cytokines decreased in the GG relative to the PG. The results of this study indicate that ginger supplementation may have a promising benefits for knee osteoarthritis and may, therefore, may warrant further study.
authors: a Department of Nutrition, Faculty of Health , Shahid Sadoughi University of Medical Sciences , Yazd , Iran.|b Yazd Diabetic Research Center , Shahid Sadoughi University of Medical Sciences , Yazd , Iran.
authors: Hassan
authors: H
authors: Mozaffari-Khosravi
authors: a Department of Nutrition, Faculty of Health , Shahid Sadoughi University of Medical Sciences , Yazd , Iran.
authors: Zahra
authors: Z
authors: Naderi
authors: c Department of Internal Medicine , Shahid Sadoughi Hospital, Shahid Sadoughi University of Medical Sciences , Yazd , Iran.
authors: Ali
authors: A
authors: Dehghan
authors: a Department of Nutrition, Faculty of Health , Shahid Sadoughi University of Medical Sciences , Yazd , Iran.
authors: Azadeh
authors: A
authors: Nadjarzadeh
authors: d Department of Pharmacology and Applied Medicine , Institute of Medical Plants, ACECR , Karaj , Iran.
authors: Hassan
authors: H
authors: Fallah Huseini
mesh_terms: D000368:Aged; D016207:Cytokines / Q000097:blood; D019587:Dietary Supplements; D004311:Double-Blind Method; D005260:Female; D020939:Zingiber officinale; D006299:Health Services for the Aged; D006801:Humans; D008297:Male; D008875:Middle Aged; D020370:Osteoarthritis, Knee / Q000097:blood / Q000188:drug therapy*; D010147:Pain Measurement; D008517:Phytotherapy; D016896:Treatment Outcome
chemical_list: D016207:Cytokines
keywords: Osteoarthritis; ginger; inflammation