title: Intracranial Extraskeletal Mesenchymal Chondrosarcoma.
abstract: BACKGROUND
  Intracranial extraskeletal mesenchymal chondrosarcomas (MCSs) are rare tumors accounting for <0.16% of intracranial tumors. They are usually described as occurring in the age group of 20-30 years and are commonly found in the frontoparietal region arising from the falx and surrounding dura. We describe 3 cases at varying ages, locations, and outcomes.
  
  
  METHODS
  A 42-year-old woman with anterior one third falx-based lesion; a 7-year-old boy with mid one third falcine lesion with hyperostosis of bone, presenting in comatose stage; and a 52-year-old woman with left posterior lateral frontal dural-based lesion are presented. Histopathology of all cases was confirmed with immunohistochemistry. All patients underwent complete excision but had varying outcomes.
  
  
  CONCLUSIONS
  Intracranial MCSs are rare malignant tumors with poor prognosis. Because of their rarity, it may not be considered as a differential diagnosis and it is often misdiagnosed radiologically, but the importance lies in the need of radical excision. The potential effect of postoperative radiotherapy and chemotherapy is controversial. This article sheds some light on variable prognosis of this tumor.
authors: Department of Neurosurgery, National Institute of Mental Health and Neurosciences, Bangalore, India.
authors: Nishanth
authors: N
authors: Sadashiva
authors: Department of Neurosurgery, National Institute of Mental Health and Neurosciences, Bangalore, India.
authors: Anil
authors: A
authors: Sharma
authors: Department of Neurosurgery, National Institute of Mental Health and Neurosciences, Bangalore, India.
authors: Dhaval
authors: D
authors: Shukla
authors: Department of Neuropathology, National Institute of Mental Health and Neurosciences, Bangalore, India.
authors: Poyuran
authors: P
authors: Rajalakshmi
authors: Department of Neuropathology, National Institute of Mental Health and Neurosciences, Bangalore, India.
authors: Anita
authors: A
authors: Mahadevan
authors: Department of Neurosurgery, National Institute of Mental Health and Neurosciences, Bangalore, India. Electronic address: bidevidr@gmail.com.
authors: Bhagavatula Indira
authors: BI
authors: Devi
mesh_terms: D000071443:12E7 Antigen / Q000378:metabolism; D000328:Adult; D001932:Brain Neoplasms / Q000000981:diagnostic imaging* / Q000378:metabolism / Q000473:pathology / Q000601:surgery; D002648:Child; D018211:Chondrosarcoma, Mesenchymal / Q000000981:diagnostic imaging* / Q000378:metabolism / Q000473:pathology / Q000601:surgery; D004388:Dura Mater / Q000000981:diagnostic imaging* / Q000378:metabolism / Q000473:pathology / Q000601:surgery; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008279:Magnetic Resonance Imaging; D008297:Male; D008577:Meningeal Neoplasms / Q000000981:diagnostic imaging* / Q000378:metabolism / Q000473:pathology / Q000601:surgery; D008875:Middle Aged; D018396:Mucin-1 / Q000378:metabolism; D009418:S100 Proteins / Q000378:metabolism; D016708:Synaptophysin / Q000378:metabolism; D014057:Tomography, X-Ray Computed; D014746:Vimentin / Q000378:metabolism
chemical_list: D000071443:12E7 Antigen; D018396:Mucin-1; D009418:S100 Proteins; D016708:Synaptophysin; D014746:Vimentin
keywords: Hemangiopericytoma; Meningeal tumor; Meningioma; Mesenchymal chondrosarcoma; Mesenchymal tumor