title: Comprehensive Evaluation of Personal, Clinical, and Radiation Dosimetric Parameters for Acute Skin Reaction during Whole Breast Radiotherapy.
abstract: Skin reaction is major problem during whole breast radiotherapy. To identify factors related to skin reactions during whole breast radiotherapy, various personal, clinical, and radiation dosimetric parameters were evaluated. From January 2012 to December 2013, a total of 125 patients who underwent breast conserving surgery and adjuvant whole breast irradiation were retrospectively reviewed. All patients had both whole breast irradiation and boost to the tumour bed. Skin reaction was measured on the first day of boost therapy based on photography of the radiation field and medical records. For each area of axilla and inferior fold, the intensity score of erythema (score 1 to 5) and extent (score 0 to 1) were summed. The relationship of various parameters to skin reaction was evaluated using chi-square and linear regression tests. The V 100 (volume receiving 100% of prescribed radiation dose, p < 0.001, both axilla and inferior fold) and age (p = 0.039 for axilla and 0.026 for inferior fold) were significant parameters in multivariate analyses. The calculated axilla dose (p = 0.003) and breast separation (p = 0.036) were also risk factors for axilla and inferior fold, respectively. Young age and large V 100 are significant factors for acute skin reaction that can be simply and cost-effectively measured.
authors: Department of Radiation Oncology, Guro Hospital, Korea University Medical Center, 148 Gurodong-ro, Guro-gu, Seoul 08308, Republic of Korea.
authors: Dae Sik
authors: DS
authors: Yang
authors: Department of Radiation Oncology, Guro Hospital, Korea University Medical Center, 148 Gurodong-ro, Guro-gu, Seoul 08308, Republic of Korea.
authors: Jung Ae
authors: JA
authors: Lee
authors: Department of Radiation Oncology, Ansan Hospital, Korea University Medical Center, 123 Jeokguem-ro, Ansan, Gyeonggi 15355, Republic of Korea.
authors: Won Sup
authors: 0000-0002-1934-0852
authors: WS
authors: Yoon
authors: Department of Radiation Oncology, Anam Hospital, Korea University Medical Center, 73 Inchon-ro, Seongbuk-gu, Seoul 02841, Republic of Korea.
authors: Nam Kwon
authors: NK
authors: Lee
authors: Department of Radiation Oncology, Anam Hospital, Korea University Medical Center, 73 Inchon-ro, Seongbuk-gu, Seoul 02841, Republic of Korea.
authors: Young Je
authors: YJ
authors: Park
authors: Department of Radiation Oncology, Anam Hospital, Korea University Medical Center, 73 Inchon-ro, Seongbuk-gu, Seoul 02841, Republic of Korea.
authors: Suk
authors: S
authors: Lee
authors: Department of Radiation Oncology, Anam Hospital, Korea University Medical Center, 73 Inchon-ro, Seongbuk-gu, Seoul 02841, Republic of Korea.
authors: Chul Yong
authors: CY
authors: Kim
authors: Department of Surgery, Ansan Hospital, Korea University Medical Center, 123 Jeokguem-ro, Ansan, Gyeonggi 15355, Republic of Korea.
authors: Gil Soo
authors: GS
authors: Son
mesh_terms: D000328:Adult; D000368:Aged; D001365:Axilla / Q000528:radiation effects; D001940:Breast / Q000000981:diagnostic imaging; D001943:Breast Neoplasms / Q000000981:diagnostic imaging / Q000532:radiotherapy*; D004890:Erythema / Q000209:etiology / Q000517:prevention & control; D005260:Female; D006801:Humans; D008875:Middle Aged; D011878:Radiotherapy / Q000009:adverse effects*; D011879:Radiotherapy Dosage; D012189:Retrospective Studies; D012867:Skin / Q000528:radiation effects*