title: Reproductive parameters of female Wistar rats treated with methylphenidate during development.
abstract: Methylphenidate (MPH), a psychoactive agent that acts mainly by blocking the uptake of dopamine, is the main drug used to treat Attention Deficit Hyperactivity Disorder in children and adolescents. During development, important changes in brain architecture and plasticity occur, these changes, sensitive to exposure to stimulant drugs, are important in the control of GnRH secretion, influencing the release of sex hormones throughout the ovarian cycle. This study investigated the effects of repeated treatment with MPH during development on reproductive parameters of adult female rats. Wistar rats received MPH 2.5mg/kg, MPH 5.0mg/kg, or tap water (gavage) from postnatal day (PND) 21 to PND 60. From PND 75, one subgroup of females was selected for evaluation of estrous cycle, estradiol levels, weight of sexual organs, and histomorphological analysis of ovary follicles and uterus. In another subgroup, the sexual and maternal behaviors were evaluated at PND 90 and on lactational day 5, respectively. No significant alterations were observed in the MPH groups. This study demonstrated that repeated administration of MPH during the period corresponding to childhood to early adulthood does not interfere in the reproductive function of female rats in adulthood.
authors: Department of Physiological Sciences, State University of Londrina, 86051-980 Londrina, Paraná, Brazil.
authors: Bruno Garcia
authors: BG
authors: Montagnini
authors: Department of Physiological Sciences, State University of Londrina, 86051-980 Londrina, Paraná, Brazil.
authors: Kennia Moura
authors: KM
authors: Silveira
authors: Department of Physiological Sciences, State University of Londrina, 86051-980 Londrina, Paraná, Brazil.
authors: Bruna Caroline
authors: BC
authors: Pierone
authors: Department of Physiological Sciences, State University of Londrina, 86051-980 Londrina, Paraná, Brazil.
authors: Nathália
authors: N
authors: de Azevedo Camim
authors: Department of Morphology, Estomatology and Physiology, University of São Paulo, 14040-900 Ribeirão Preto, São Paulo, Brazil.
authors: Janete Aparecida
authors: JA
authors: Anselmo-Franci
authors: Department of Biology, State University of Londrina, 86051-980 Londrina, Paraná, Brazil.
authors: Suzana
authors: S
authors: de Fátima Paccola Mesquita
authors: Department of Physiology, Botucatu Biosciences Institute, São Paulo State University, 18618-970 Botucatu, São Paulo, Brazil.
authors: Ana Carolina Inhasz
authors: ACI
authors: Kiss
authors: Department of Physiological Sciences, State University of Londrina, 86051-980 Londrina, Paraná, Brazil. Electronic address: dcgerardin@uel.br.
authors: Daniela Cristina Ceccatto
authors: DCC
authors: Gerardin
mesh_terms: D000375:Aging / Q000187:drug effects*; D000704:Analysis of Variance; D000818:Animals; D000831:Animals, Newborn; D001835:Body Weight / Q000187:drug effects; D000697:Central Nervous System Stimulants / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004958:Estradiol / Q000097:blood; D030762:Estrous Cycle / Q000187:drug effects; D005260:Female; D008297:Male; D008425:Maternal Behavior / Q000187:drug effects; D008774:Methylphenidate / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D012098:Reproduction / Q000187:drug effects*; D012726:Sexual Behavior, Animal / Q000187:drug effects; D046468:Sexual Development / Q000187:drug effects*
chemical_list: D000697:Central Nervous System Stimulants; D008774:Methylphenidate; D004958:Estradiol
keywords: Attention-deficit/hyperactivity disorder; Development; Female rat; Methylphenidate