title: Development of Antibacterial Drugs by Targeting Toll-Like Receptors.
abstract: The invading microbial pathogens are controlled by the rapid and effective innate immune responses sequentially formation of the long-lasting adaptive memories. Toll-like receptors (TLRs) play a vital role in innate and adaptive immune response by function as a bridge to modulate the immune response. Further, genetic studies in human or animals showed that regulation of TLR signaling contributes to the antibacterial efficacy, and developing novel reagent to modulate TLR related immune response becomes an interesting therapy method to against bacterial infections. Herein we review the recent developments of this area, focusing on the reagent of synthetic molecules, natural products and peptides (or proteins), as TLR-related antibacterial drugs.
authors: Qun
authors: Q
authors: Xu
authors: Gengzheng
authors: G
authors: Zhu
authors: Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education, Beijing, 100032, China.
authors: Jing
authors: J
authors: Li
authors: Department of Chemistry, Tsinghua University, Beijing, 100082, China and Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, 510515, China.
authors: Kui
authors: K
authors: Cheng
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D018716:Molecular Mimicry; D051193:Toll-Like Receptors / Q000187:drug effects*
chemical_list: D000900:Anti-Bacterial Agents; D051193:Toll-Like Receptors