title: Rapid response of the steatosis-sensing hepatokine LECT2 during diet-induced weight cycling in mice.
abstract: Dieting often leads to body weight cycling involving repeated weight loss and regain. However, little information is available regarding rapid-response serum markers of overnutrition that predict body weight alterations during weight cycling. Here, we report the rapid response of serum leukocyte cell-derived chemotaxin 2 (LECT2), a hepatokine that induces insulin resistance in skeletal muscle, during diet-induced weight cycling in mice. A switch from a high-fat diet (HFD) to a regular diet (RD) in obese mice gradually decreased body weight but rapidly decreased serum LECT2 levels within 10 days. In contrast, a switch from a RD to a HFD rapidly elevated serum LECT2 levels. Serum LECT2 levels showed a positive correlation with liver triglyceride contents but not with adipose tissue weight. This study demonstrates the rapid response of LECT2 preceding body weight alterations during weight cycling in mice and suggests that measurement of serum LECT2 may be clinically useful in the management of obesity.
authors: Division of Natural System, Graduate School of Natural Science and Technology, Kanazawa University, Kanazawa, Ishikawa 920-1192, Japan; Department of Endocrinology and Metabolism, Kanazawa University Graduate School of Medical Sciences, Kanazawa, Ishikawa 920-8641, Japan.
authors: Keita
authors: K
authors: Chikamoto
authors: Department of Endocrinology and Metabolism, Kanazawa University Graduate School of Medical Sciences, Kanazawa, Ishikawa 920-8641, Japan; PRESTO, Japan Science and Technology Agency, Kawaguchi, Saitama 332-0012, Japan. Electronic address: hmisu@m-kanazawa.jp.
authors: Hirofumi
authors: H
authors: Misu
authors: Department of Endocrinology and Metabolism, Kanazawa University Graduate School of Medical Sciences, Kanazawa, Ishikawa 920-8641, Japan; Department of System Biology, Kanazawa University Graduate School of Medical Sciences, Kanazawa, Ishikawa 920-8641, Japan.
authors: Hiroaki
authors: H
authors: Takayama
authors: Department of Endocrinology and Metabolism, Kanazawa University Graduate School of Medical Sciences, Kanazawa, Ishikawa 920-8641, Japan; Department of System Biology, Kanazawa University Graduate School of Medical Sciences, Kanazawa, Ishikawa 920-8641, Japan.
authors: Akihiro
authors: A
authors: Kikuchi
authors: Department of Endocrinology and Metabolism, Kanazawa University Graduate School of Medical Sciences, Kanazawa, Ishikawa 920-8641, Japan; Department of System Biology, Kanazawa University Graduate School of Medical Sciences, Kanazawa, Ishikawa 920-8641, Japan.
authors: Kiyo-Aki
authors: KA
authors: Ishii
authors: Department of Endocrinology and Metabolism, Kanazawa University Graduate School of Medical Sciences, Kanazawa, Ishikawa 920-8641, Japan.
authors: Fei
authors: F
authors: Lan
authors: Department of Endocrinology and Metabolism, Kanazawa University Graduate School of Medical Sciences, Kanazawa, Ishikawa 920-8641, Japan; Department of System Biology, Kanazawa University Graduate School of Medical Sciences, Kanazawa, Ishikawa 920-8641, Japan.
authors: Noboru
authors: N
authors: Takata
authors: Department of Endocrinology and Metabolism, Kanazawa University Graduate School of Medical Sciences, Kanazawa, Ishikawa 920-8641, Japan.
authors: Natsumi
authors: N
authors: Tajima-Shirasaki
authors: Department of Endocrinology and Metabolism, Kanazawa University Graduate School of Medical Sciences, Kanazawa, Ishikawa 920-8641, Japan.
authors: Yumie
authors: Y
authors: Takeshita
authors: Division of Natural System, Graduate School of Natural Science and Technology, Kanazawa University, Kanazawa, Ishikawa 920-1192, Japan; Department of Endocrinology and Metabolism, Kanazawa University Graduate School of Medical Sciences, Kanazawa, Ishikawa 920-8641, Japan.
authors: Hirohiko
authors: H
authors: Tsugane
authors: Department of System Biology, Kanazawa University Graduate School of Medical Sciences, Kanazawa, Ishikawa 920-8641, Japan.
authors: Shuichi
authors: S
authors: Kaneko
authors: Division of Natural System, Graduate School of Natural Science and Technology, Kanazawa University, Kanazawa, Ishikawa 920-1192, Japan; Institute of Science and Engineering, Faculty of Natural System, Kanazawa University, Kanazawa, Ishikawa 920-1192, Japan.
authors: Seiichi
authors: S
authors: Matsugo
authors: Department of Endocrinology and Metabolism, Kanazawa University Graduate School of Medical Sciences, Kanazawa, Ishikawa 920-8641, Japan. Electronic address: ttakamura@m-kanazawa.jp.
authors: Toshinari
authors: T
authors: Takamura
mesh_terms: D000273:Adipose Tissue / Q000473:pathology; D050154:Adiposity; D000818:Animals; D015415:Biomarkers / Q000378:metabolism; D001835:Body Weight; D059305:Diet, High-Fat; D004195:Disease Models, Animal; D005234:Fatty Liver / Q000378:metabolism* / Q000473:pathology*; D007328:Insulin / Q000097:blood; D036341:Intercellular Signaling Peptides and Proteins / Q000097:blood / Q000378:metabolism*; D008099:Liver / Q000378:metabolism / Q000473:pathology; D008297:Male; D008810:Mice, Inbred C57BL; D009929:Organ Size; D044343:Overnutrition / Q000097:blood / Q000473:pathology
chemical_list: D015415:Biomarkers; D007328:Insulin; D036341:Intercellular Signaling Peptides and Proteins; C491213:Lect2 protein, mouse
keywords: Fatty liver; Leukocyte cell-derived chemotaxin 2 (LECT2); Obesity; Rapid turnover protein; Weight cycling