title: Inflammation and nutritional status as predictors of physical performance and strength loss during hospitalization.
abstract: The aim of this study was to examine changes in physical performance and handgrip strength during hospitalization as well as to evaluate their interrelationship with inflammatory and nutritional status.
  
  
  
  Data were available on 302 elderly patients with a mean age of 80.83±7.14 years. Handgrip strength, gait speed and chair-stand test were assessed at admission and before discharge. In all subjects, serum CRP values and Mini Nutritional Assessment scores were also evaluated.
  
  
  
  The risk of worsening in chair-stand test performance was 4.2 (95% confidence interval (CI): 1.574-11.310) for subjects with simultaneous presence of malnutrition and CRP⩾50 and 3.3 mg/dl (95% CI: 1.127-9.423) for subjects with CRP⩾50 mg/l not malnourished in comparison with subjects with Mini Nutritional Assessment (MNA)⩾24 and CRP⩽10 mg/l. The risk of handgrip strength loss was 8.8 (95% CI: 3.545-21.662) in subjects with simultaneous presence of malnutrition and CRP⩾50 and 2.9  mg/dl (95% CI: 1.223-6.783) in subjects with CRP⩾50 mg/l not malnourished in comparison with subjects with MNA⩾24 and CRP⩽10 mg/l.
  
  
  
  Simultaneous presence of high CRP values and malnutrition determines an additive effect on muscle strength loss and physical performance.
authors: Section of Geriatrics, Department of Medicine, Division of Geriatrics, University of Verona, Verona, Italy.
authors: A P
authors: AP
authors: Rossi
authors: Section of Geriatrics, Department of Medicine, Division of Geriatrics, University of Verona, Verona, Italy.
authors: V
authors: V
authors: Zanandrea
authors: Section of Geriatrics, Department of Medicine, Division of Geriatrics, University of Verona, Verona, Italy.
authors: E
authors: E
authors: Zoico
authors: Section of Geriatrics, Department of Medicine, Division of Geriatrics, University of Verona, Verona, Italy.
authors: M
authors: M
authors: Zanardo
authors: Section of Geriatrics, Department of Medicine, Division of Geriatrics, University of Verona, Verona, Italy.
authors: C
authors: C
authors: Caliari
authors: Section of Geriatrics, Department of Medicine, Division of Geriatrics, University of Verona, Verona, Italy.
authors: S
authors: S
authors: Confente
authors: Section of Geriatrics, Department of Medicine, Division of Geriatrics, University of Verona, Verona, Italy.
authors: S
authors: S
authors: Gabriele
authors: Section of Geriatrics, Department of Medicine, Division of Geriatrics, University of Verona, Verona, Italy.
authors: G
authors: G
authors: Mazzali
authors: Section of Geriatrics, Department of Medicine, Division of Geriatrics, University of Verona, Verona, Italy.
authors: F
authors: F
authors: Fantin
authors: Section of Geriatrics, Department of Medicine, Division of Geriatrics, University of Verona, Verona, Italy.
authors: M
authors: M
authors: Zamboni
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002097:C-Reactive Protein / Q000032:analysis; D015444:Exercise / Q000502:physiology*; D005080:Exercise Test / Q000379:methods; D005260:Female; D015577:Geriatric Assessment; D018737:Hand Strength / Q000502:physiology; D006760:Hospitalization; D006801:Humans; D007249:Inflammation / Q000503:physiopathology*; D008297:Male; D044342:Malnutrition / Q000503:physiopathology*; D053580:Muscle Strength; D015596:Nutrition Assessment; D009752:Nutritional Status / Q000502:physiology*; D012044:Regression Analysis
chemical_list: D002097:C-Reactive Protein