title: Sedentary behavior in obese pregnant women is associated with inflammatory markers and lipid profile but not with glucose metabolism.
abstract: Sedentary behavior is an independent risk factor for the metabolic syndrome, but the role of sedentary behavior in the development of gestational diabetes is unclear.
  
  
  
  This study tested the hypothesis that less sedentary behavior is related to better insulin sensitivity, lipid and cytokine profile in obese pregnant women.
  
  
  
  A longitudinal observational study with 46 overweight and obese pregnant women was conducted. Sedentary behavior was measured objectively using accelerometers at 15, 24 and 32weeks of gestation, and at those time points fasting blood was taken as well. A 100g oral glucose tolerance test was performed at 24 and 32weeks. Levels of glucose, insulin, total cholesterol, HDL, LDL, triglycerides were measured, as well as cytokines. The relationship between sedentary behavior and metabolic outcomes was assessed using linear regression analysis.
  
  
  
  Women spent almost 60% of their time sitting throughout pregnancy. In cross-sectional analyses, an association of sedentary time at 24weeks was found with increased total cholesterol and HDL. More sedentary time was associated with lower IL-6 at 24weeks and with higher IL-10, TNF-α and leptin levels at 32weeks of pregnancy. Changes in sedentary time were not associated with changes in any of the metabolic outcomes.
  
  
  
  In conclusion, time spent sedentary in pregnancy was associated with lipid and cytokine profile. Whether decreasing sedentary time beneficially influences lipid profile and influences cytokine profiles of overweight and obese women needs to be assessed in future intervention studies.
authors: Dept. of Public and Occupational Health, EMGO(+) Institute for Health and Care Research, VU University Medical Centre, Van der Boechorststraat 7, 1081 BT Amsterdam, The Netherlands.
authors: Minakshi
authors: M
authors: Nayak
authors: Inst. of Exp. and Clin. Pharmacology, Medical University of Graz, Universitätsplatz 4, 8010 Graz, Austria.
authors: Miriam
authors: M
authors: Peinhaupt
authors: Inst. of Exp. and Clin. Pharmacology, Medical University of Graz, Universitätsplatz 4, 8010 Graz, Austria.
authors: Akos
authors: A
authors: Heinemann
authors: Dept. of Endocrinology, VU University Medical Centre, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands.
authors: Marelise E W
authors: ME
authors: Eekhoff
authors: Dept. of Public and Occupational Health, EMGO(+) Institute for Health and Care Research, VU University Medical Centre, Van der Boechorststraat 7, 1081 BT Amsterdam, The Netherlands.
authors: Willem
authors: W
authors: van Mechelen
authors: Dept. of Obstetrics and Gynecology, Medical University Graz, Auenbruggerplatz 14, 8036 Graz, Austria.
authors: Gernot
authors: G
authors: Desoye
authors: Dept. of Public and Occupational Health, EMGO(+) Institute for Health and Care Research, VU University Medical Centre, Van der Boechorststraat 7, 1081 BT Amsterdam, The Netherlands; Institute of Sport Science, University of Graz, Mozartgasse 14, 8010 Graz, Austria. Electronic address: mireille.van-poppel@uni-graz.at.
authors: Mireille N M
authors: MN
authors: van Poppel
mesh_terms: D000328:Adult; D016207:Cytokines / Q000097:blood*; D015444:Exercise; D005260:Female; D006801:Humans; D008055:Lipids / Q000097:blood*; D008137:Longitudinal Studies; D009765:Obesity / Q000097:blood*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000097:blood*
chemical_list: D016207:Cytokines; D008055:Lipids
keywords: Cytokines; Insulin sensitivity; Pregnancy; Sedentary behavior