title: Sex differences in the prevalence of metabolic syndrome and its components in hypopituitary patients: comparison with an age- and sex-matched nationwide control group.
abstract: OBJECTIVE
  Hypopituitary patients have a reduced life expectancy owing to cardiovascular events. We investigated the prevalence of metabolic syndrome in hypopituitary patients for a follow-up period of at least 1 year in comparison with an age- and sex-matched nationwide control group.
  
  
  METHODS
  A total of 515 patients with hypopituitarism who visited Seoul National University Hospital between January 2000 and December 2010 were included. Data for an age- and sex-matched control group were obtained from the Korean National Health and Nutrition Examination Surveys (KNHANES) (n = 1545). Metabolic syndrome was defined according to the modified National Cholesterol Education Program (NCEP-ATPIII).
  
  
  RESULTS
  The prevalence of metabolic syndrome did not differ significantly between the hypopituitary and control groups for men (34.9 versus 30.3 %), but the risk of metabolic syndrome was higher in hypopituitary women than in controls (39.8 versus 28.5 %). In both sexes, the risks of central obesity and dyslipidemia were higher in the hypopituitary group than in the control group. Men had lower risks of hypertension and hyperglycemia in the hypopituitary group, which attenuated the risk of metabolic syndrome. Age greater than 40 years and obesity (BMI ≥25 kg/m2) contributed to a higher risk of metabolic syndrome.
  
  
  CONCLUSIONS
  The metabolic syndrome prevalence was higher in the hypopituitry group than in the control group in Korean women, and this was attributed to an increased risk of central obesity and dyslipidemia. Accordingly, early intervention to reduce metabolic syndrome needed in hypopituitary patients, i.e. women.
authors: Diabetes Center and Endocrine Clinic, Pusan National University Yangsan Hospital, Pusan, Republic of Korea.
authors: Ah Reum
authors: AR
authors: Khang
authors: Department of Internal Medicine, Chungbuk National University College of Medicine, Cheongju, Republic of Korea.
authors: Eu Jeong
authors: EJ
authors: Ku
authors: Department of Internal Medicine, Seoul National University College of Medicine, 101 Daehak-ro, Jongno-gu, Seoul, 03080, Republic of Korea.
authors: Ye An
authors: YA
authors: Kim
authors: Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.
authors: Eun
authors: E
authors: Roh
authors: Department of Internal Medicine, Seoul National University College of Medicine, 101 Daehak-ro, Jongno-gu, Seoul, 03080, Republic of Korea.
authors: Jae Hyun
authors: JH
authors: Bae
authors: Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Republic of Korea.
authors: Tae Jung
authors: TJ
authors: Oh
authors: Department of Internal Medicine, Seoul National University College of Medicine, 101 Daehak-ro, Jongno-gu, Seoul, 03080, Republic of Korea.|Department of Internal Medicine, Seoul Metropolitan Government Borame Medical Center, Seoul, Republic of Korea.
authors: Sang Wan
authors: SW
authors: Kim
authors: Department of Internal Medicine, Seoul National University College of Medicine, 101 Daehak-ro, Jongno-gu, Seoul, 03080, Republic of Korea.
authors: Chan Soo
authors: CS
authors: Shin
authors: Department of Internal Medicine, Seoul National University College of Medicine, 101 Daehak-ro, Jongno-gu, Seoul, 03080, Republic of Korea.
authors: Seong Yeon
authors: SY
authors: Kim
authors: Department of Internal Medicine, Seoul National University College of Medicine, 101 Daehak-ro, Jongno-gu, Seoul, 03080, Republic of Korea. jhkxingfu@gmail.com.
authors: Jung Hee
authors: JH
authors: Kim
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D007018:Hypopituitarism / Q000150:complications*; D008297:Male; D024821:Metabolic Syndrome / Q000150:complications / Q000453:epidemiology*; D008875:Middle Aged; D015995:Prevalence; D056910:Republic of Korea / Q000453:epidemiology; D012189:Retrospective Studies; D012727:Sex Characteristics
keywords: Dyslipidemia; Hypopituitarism; Metabolic syndrome; Obesity