title: Fabrication of a Dipole-assisted Solid Phase Extraction Microchip for Trace Metal Analysis in Water Samples.
abstract: This paper describes a fabrication protocol for a dipole-assisted solid phase extraction (SPE) microchip available for trace metal analysis in water samples. A brief overview of the evolution of chip-based SPE techniques is provided. This is followed by an introduction to specific polymeric materials and their role in SPE. To develop an innovative dipole-assisted SPE technique, a chlorine (Cl)-containing SPE functionality was implanted into a poly(methyl methacrylate) (PMMA) microchip. Herein, diverse analytical techniques including contact angle analysis, Raman spectroscopic analysis, and laser ablation-inductively coupled plasma-mass spectrometry (LA-ICP-MS) analysis were employed to validate the utility of the implantation protocol of the C-Cl moieties on the PMMA. The analytical results of the X-ray absorption near-edge structure (XANES) analysis also demonstrated the feasibility of the Cl-containing PMMA used as an extraction medium by virtue of the dipole-ion interactions between the highly electronegative C-Cl moieties and the positively charged metal ions.
authors: Department of Biomedical Engineering and Environmental Sciences, National Tsing Hua University.
authors: Tsung-Ting
authors: TT
authors: Shih
authors: Center for Measurement Standards, Industrial Technology Research Institute; ihhsu@itri.org.tw.
authors: I-Hsiang
authors: IH
authors: Hsu
authors: Department of Biomedical Engineering and Environmental Sciences, National Tsing Hua University.
authors: Ping-Hung
authors: PH
authors: Chen
authors: Department of Biomedical Engineering and Environmental Sciences, National Tsing Hua University.
authors: Shun-Niang
authors: SN
authors: Chen
authors: Department of Biomedical Engineering and Environmental Sciences, National Tsing Hua University.
authors: Sheng-Hao
authors: SH
authors: Tseng
authors: National Synchrotron Radiation Research Center.
authors: Ming-Jay
authors: MJ
authors: Deng
authors: Department of Chemistry, National Changhua University of Education.
authors: Yang-Wei
authors: YW
authors: Lin
authors: Department of Biomedical Engineering and Environmental Sciences, National Tsing Hua University.
authors: Yuh-Chang
authors: YC
authors: Sun
mesh_terms: D013058:Mass Spectrometry / Q000379:methods*; D008670:Metals / Q000032:analysis*; D011108:Polymers / Q000032:analysis*; D052616:Solid Phase Extraction / Q000379:methods*; D014131:Trace Elements / Q000032:analysis*
chemical_list: D008670:Metals; D011108:Polymers; D014131:Trace Elements