title: Surgery combined with postoperative125I seed brachytherapy for the treatment of mucoepidermoid carcinoma of the parotid gland in pediatric patients.
abstract: This retrospective study was undertaken to analyze the effectiveness and safety of surgery combined with postoperative125I seed brachytherapy in the treatment of mucoepidermoid carcinoma (MEC) of the parotid gland with risk factors in pediatric patients.
  
  
  
  From September 2002 to January 2012, 24 patients, ages 5-16 years (mean, 13.2 years; median, 12.3 years), with MEC of the parotid gland were included. Patients with high risk factors received125I seed brachytherapy (median actuarial D90, 97 Gy) within 4 weeks following surgery. Radioactivity was 18.5-33.3 MBq per seed and the prescription dose was 60-120 Gy. Overall and disease-free survival rates, local control rate, and distant metastasis were recorded. Radiation-associated late side effects, including dermatitis, hearing loss, thyroid nodules, and secondary malignancy, were also evaluated.
  
  
  
  During the follow-up period of 5-13.4 years (median, 7.2 years), the overall and disease-free survival rates were all 100%. No patients developed local recurrence, regional/distant metastasis, and no severe radiation-associated complications including the second malignancy were noted.
  
  
  
  Surgery combined with postoperative125I seed brachytherapy is effective and safe in the treatment of MEC of the parotid gland in pediatric patients, with no evidence of severe late radiation-related complications. More patients and longer follow-up data are still needed to prove the efficacy of125I brachytherapy.
authors: Capital Medical University School of Stomatology, Beijing, P.R. China.
authors: Ming-Hui
authors: MH
authors: Mao
authors: Capital Medical University School of Stomatology, Beijing, P.R. China.|Department of Oral and Maxillofacial Surgery, Peking University School and Hospital of Stomatology, Beijing, P.R. China.
authors: Lei
authors: L
authors: Zheng
authors: Capital Medical University School of Stomatology, Beijing, P.R. China.|Department of Dental Surgery, Daqing Oil Field General Hospital, Daqing, P.R. China.
authors: Xi-Ming
authors: XM
authors: Wang
authors: Capital Medical University School of Stomatology, Beijing, P.R. China.
authors: Hua
authors: H
authors: Li
authors: Capital Medical University School of Stomatology, Beijing, P.R. China.
authors: Li-Zheng
authors: LZ
authors: Qin
authors: Capital Medical University School of Stomatology, Beijing, P.R. China.|Department of Oral and Maxillofacial Surgery, Peking University School and Hospital of Stomatology, Beijing, P.R. China.
authors: Jie
authors: J
authors: Zhang
authors: Capital Medical University School of Stomatology, Beijing, P.R. China.
authors: Zheng-Xue
authors: ZX
authors: Han
authors: Capital Medical University School of Stomatology, Beijing, P.R. China.|Department of Oral and Maxillofacial Surgery, Peking University School and Hospital of Stomatology, Beijing, P.R. China.
authors: Jian-Guo
authors: JG
authors: Zhang
mesh_terms: D000293:Adolescent; D001918:Brachytherapy; D018277:Carcinoma, Mucoepidermoid / Q000473:pathology / Q000628:therapy*; D002648:Child; D002675:Child, Preschool; D003131:Combined Modality Therapy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007457:Iodine Radioisotopes / Q000627:therapeutic use*; D008297:Male; D009367:Neoplasm Staging; D010307:Parotid Neoplasms / Q000473:pathology / Q000628:therapy*; D011182:Postoperative Care; D011379:Prognosis; D011879:Radiotherapy Dosage; D012189:Retrospective Studies; D015996:Survival Rate
chemical_list: D007457:Iodine Radioisotopes
keywords: 125I seed brachytherapy; mucoepidermoid carcinoma; parotid gland; pediatric