title: DDRprot: a database of DNA damage response-related proteins.
abstract: The DNA Damage Response (DDR) signalling network is an essential system that protects the genome's integrity. The DDRprot database presented here is a resource that integrates manually curated information on the human DDR network and its sub-pathways. For each particular DDR protein, we present detailed information about its function. If involved in post-translational modifications (PTMs) with each other, we depict the position of the modified residue/s in the three-dimensional structures, when resolved structures are available for the proteins. All this information is linked to the original publication from where it was obtained. Phylogenetic information is also shown, including time of emergence and conservation across 47 selected species, family trees and sequence alignments of homologues. The DDRprot database can be queried by different criteria: pathways, species, evolutionary age or involvement in (PTM). Sequence searches using hidden Markov models can be also used.Database URL: http://ddr.cbbio.es.
authors: Computational Biology and Bioinformatics Group, Institute of Biomedicine of Seville, 41013 Sevilla, Spain.
authors: Eduardo
authors: E
authors: Andrés-León
authors: Computational Biology and Bioinformatics Group, Institute of Biomedicine of Seville, 41013 Sevilla, Spain.
authors: Ildefonso
authors: I
authors: Cases
authors: Computational Biology and Bioinformatics Group, Institute of Biomedicine of Seville, 41013 Sevilla, Spain Cell Movements in Development and Disease Lab, Instituto de Neurociencias (CSIC-UMH), 03550 Alicante, Spain.
authors: Aida
authors: A
authors: Arcas
authors: Computational Biology and Bioinformatics Group, Institute of Biomedicine of Seville, 41013 Sevilla, Spain arojas-ibis@us.es.
authors: Ana M
authors: AM
authors: Rojas
mesh_terms: D000818:Animals; D004249:DNA Damage; D030562:Databases, Protein; D006801:Humans; D010802:Phylogeny; D000072417:Protein Domains; D013045:Species Specificity