title: Surgery for chronic radiation enteritis: outcome and risk factors.
abstract: Surgery is required in approximately one-third of patients with chronic radiation enteritis (CRE). The aim of this study was to explore the short- and long-term outcomes after surgery for CRE and risk factors of postoperative morbidity.
  
  
  
  Clinical features and surgical outcomes of patients undergoing surgery for CRE were retrospectively reviewed. Risk factors of postoperative morbidity were analyzed using univariate and multivariate analysis. Survival and reoperation rates for CRE were evaluated.
  
  
  
  Among the 404 patients included, 351 patients (86.88%) received resectional surgery, whereas the remaining patients received conservative procedures. No differences were detected between patients with resection and those without resection with regard to major morbidity (P = 0.486) and surgical complications (P = 0.715). Laparoscopy resulted in a shorter postoperative hospital stay (P = 0.035). After multivariate analysis, history of hypertension (odds ratio [OR] = 2.490; P = 0.046), previous acute radiation enteritis (OR = 1.832; P = 0.033), intraoperative blood loss of more than 200 mL (OR = 2.235; P = 0.006), and thrombocytopenia (OR = 2.544; P = 0.016) were determined as independent predictors of postoperative major morbidity. During follow-up, 22 patients required reoperation for CRE recurrence, and the reoperation rate was significantly lower in patients receiving resectional surgery (P = 0.005).
  
  
  
  Resection is feasible for CRE with acceptable postoperative morbidity and lower reoperation rate. Correction of preoperative thrombocytopenia, minimizing intraoperative blood loss, and close monitoring of hypertensive patients and those with history of acute radiation enteritis are critical to reduce postoperative complications.
authors: Department of General Surgery, Jinling Hospital, School of Medicine, Nanjing University, Nanjing, China.
authors: Yuhua
authors: Y
authors: Huang
authors: Department of General Surgery, Jinling Hospital, School of Medicine, Nanjing University, Nanjing, China.
authors: Feilong
authors: F
authors: Guo
authors: Department of General Surgery, Jinling Hospital, School of Medicine, Nanjing University, Nanjing, China.
authors: Danhua
authors: D
authors: Yao
authors: Department of General Surgery, Jinling Hospital, School of Medicine, Nanjing University, Nanjing, China. Electronic address: liyoushengjz@126.com.
authors: Yousheng
authors: Y
authors: Li
authors: Department of General Surgery, Jinling Hospital, School of Medicine, Nanjing University, Nanjing, China.
authors: Jieshou
authors: J
authors: Li
mesh_terms: D000328:Adult; D000368:Aged; D002681:China / Q000453:epidemiology; D002908:Chronic Disease; D004751:Enteritis / Q000601:surgery*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000532:radiotherapy; D011183:Postoperative Complications / Q000453:epidemiology*; D011832:Radiation Injuries / Q000601:surgery*; D012189:Retrospective Studies; D012307:Risk Factors; D055815:Young Adult
keywords: Chronic radiation enteritis; Outcome; Postoperative morbidity; Risk factor