title: Nanoparticle "switch-on" by tetrazine triggering.
abstract: This work describes how a small-molecule chemical trigger, reacting through the mediatory of an inverse electron demand Diels-Alder reaction, results in enhanced cellular uptake and selective nanoparticle disintegration and cargo liberation, via gross polymeric morphological alterations. The power of these responsive nanoparticles is demonstrated through encapsulation of the anti-cancer agent doxorubicin and its triggered release, allowing controlled cell death in response to a small-molecule chemical trigger.
authors: School of Chemistry, University of Edinburgh, Joseph Black Building, Edinburgh, EH9 3FJ, UK. jin.geng@ed.ac.uk mark.bradley@ed.ac.uk.
authors: Kevin
authors: K
authors: Neumann
authors: Sarthak
authors: S
authors: Jain
authors: Jin
authors: J
authors: Geng
authors: Mark
authors: M
authors: Bradley