title: Anti-cysticercus antibody detection in saliva as a potential diagnostic tool for neurocysticercosis.
abstract: OBJECTIVE
  This study was planned to determine the usefulness of anti-cysticercus IgG antibody detection in saliva for neurocysticercosis (NCC) diagnosis, along with serum C-reactive protein (CRP) level to serve as a surrogate marker.
  
  
  METHODS
  In this prospective study of 14 months duration, blood and saliva samples were collected from 40 patients suspected to be suffering from NCC and were subjected to anti-cysticercus IgG antibody detection by ELISA. Serum CRP levels were estimated as acute-phase reactant by high sensitivity CRP ELISA.
  
  
  RESULTS
  Anti-cysticercus IgG was detected in serum and saliva of 34 and 30 patients, respectively. Cases positive for salivary antibody were positive for serum antibody and their serum CRP level was higher than normal. Cases negative for salivary antibody had low serum CRP levels. Anti-cysticercus IgG detection in saliva was 88.24% sensitive, 100% specific, and had a positive predictive value of 100% and negative predictive value of 60%. Positive salivary anti-cysticercus IgG and high serum CRP level showed a significant association. Difference between CRP levels of patients positive for anti-cysticercus antibody in both serum and saliva, and patients positive for antibody in serum but not saliva was highly significant.
  
  
  CONCLUSIONS
  Saliva, being painless and noninvasive, can be used as alternative to serum for NCC diagnosis.
authors: Department of Microbiology, University College of Medical Sciences and Guru Teg Bahadur Hospital, New Delhi, India.
authors: Rumpa
authors: R
authors: Saha
authors: Department of Microbiology, University College of Medical Sciences and Guru Teg Bahadur Hospital, New Delhi, India.
authors: Priyamvada
authors: P
authors: Roy
authors: Department of Microbiology, University College of Medical Sciences and Guru Teg Bahadur Hospital, New Delhi, India.
authors: Shukla
authors: S
authors: Das
authors: Department of Pediatrics, University College of Medical Sciences and Guru Teg Bahadur Hospital, New Delhi, India.
authors: Dheeraj
authors: D
authors: Shah
authors: Department of Medicine, University College of Medical Sciences and Guru Teg Bahadur Hospital, New Delhi, India.
authors: Sunil
authors: S
authors: Agarwal
authors: Department of Microbiology, University College of Medical Sciences and Guru Teg Bahadur Hospital, New Delhi, India.
authors: Iqbal Rajinder
authors: IR
authors: Kaur
keywords: Antibody; C-reactive protein; diagnosis; neurocysticercosis; saliva