title: Cadaveric bone marrow mesenchymal stem cells: first experience treating a patient with large severe burns.
abstract: BACKGROUND
  In January 2005, Rasulov et al. originally published "First experience in the use of bone marrow mesenchymal stem cells (MSCs) for the treatment of a patient with deep skin burns". Here, we present the first ever treated patient with cadaveric bone marrow mesenchymal stem cells (CMSCs) in the history of Medicine.
  
  
  METHODS
  A young man, who severely burned 60 % of his total body surface with 30 % of full-thickness burns while working with a grass trimmer that exploded, was involved in the study. MSCs were obtained from the bone marrow of a cadaver donor in a routine procurement procedure of CUCAIBA, the Province of Buenos Aires, Argentina, Ministry of Health, Transplantation Agency, cultured, expanded, and applied on the burned surfaces using a fibrin spray after early escharotomy.
  
  
  RESULTS
  So far, our preliminary experience and our early results have been very impressive showing an outstanding safety data as well as some impressive good results in the use of CMSCs.
  
  
  CONCLUSIONS
  Based on all this, we think that improvements in the use of stem cells for burns might be possible in the near future and a lot of time as well as many lives could be saved by many other research teams all over the world. CMSCs will probably be a real scientific opportunity in Regenerative Medicine as well as in Transplantation.
authors: Tissue Engineering, Regenerative Medicine and Cell Therapies Laboratory, CUCAIBA, Province of Buenos Aires Ministry of Health, Transplantation Program, La Plata, Province of Buenos Aires, Argentina.
authors: Eduardo
authors: E
authors: Mansilla
authors: Tissue Engineering, Regenerative Medicine and Cell Therapies Laboratory, CUCAIBA, Province of Buenos Aires Ministry of Health, Transplantation Program, La Plata, Province of Buenos Aires, Argentina.
authors: Gustavo H
authors: GH
authors: Marín
authors: Burns and Plastic Surgery Department, San Martín Hospital, Province of Buenos Aires Ministry of Health, La Plata, Province of Buenos Aires, Argentina.
authors: Mirta
authors: M
authors: Berges
authors: Burns and Plastic Surgery Department, San Martín Hospital, Province of Buenos Aires Ministry of Health, La Plata, Province of Buenos Aires, Argentina.
authors: Silvia
authors: S
authors: Scafatti
authors: Burns and Plastic Surgery Department, San Martín Hospital, Province of Buenos Aires Ministry of Health, La Plata, Province of Buenos Aires, Argentina.
authors: Jaime
authors: J
authors: Rivas
authors: Burns and Plastic Surgery Department, San Martín Hospital, Province of Buenos Aires Ministry of Health, La Plata, Province of Buenos Aires, Argentina.
authors: Andrea
authors: A
authors: Núñez
authors: Burns and Plastic Surgery Department, San Martín Hospital, Province of Buenos Aires Ministry of Health, La Plata, Province of Buenos Aires, Argentina.
authors: Martin
authors: M
authors: Menvielle
authors: Burns and Plastic Surgery Department, San Martín Hospital, Province of Buenos Aires Ministry of Health, La Plata, Province of Buenos Aires, Argentina.
authors: Roberto
authors: R
authors: Lamonega
authors: Burns and Plastic Surgery Department, San Martín Hospital, Province of Buenos Aires Ministry of Health, La Plata, Province of Buenos Aires, Argentina.
authors: Cecilia
authors: C
authors: Gardiner
authors: Burns Hospital, Buenos Aires City, Argentina.
authors: Hugo
authors: H
authors: Drago
authors: Burns Hospital, Buenos Aires City, Argentina.
authors: Flavio
authors: F
authors: Sturla
authors: Burns Hospital, Buenos Aires City, Argentina.
authors: Mercedes
authors: M
authors: Portas
authors: Burns Hospital, Buenos Aires City, Argentina.
authors: Silvia
authors: S
authors: Bossi
authors: Tissue Engineering, Regenerative Medicine and Cell Therapies Laboratory, CUCAIBA, Province of Buenos Aires Ministry of Health, Transplantation Program, La Plata, Province of Buenos Aires, Argentina.
authors: Maria Victoria
authors: MV
authors: Castuma
authors: Department of Chemistry, Mayaguez Campus, University of Puerto Rico, Mayaguez Puerto Rico, USA.
authors: Sandra
authors: S
authors: Peña Luengas
authors: Tissue Engineering, Regenerative Medicine and Cell Therapies Laboratory, CUCAIBA, Province of Buenos Aires Ministry of Health, Transplantation Program, La Plata, Province of Buenos Aires, Argentina.
authors: Gustavo
authors: G
authors: Roque
authors: Tissue Engineering, Regenerative Medicine and Cell Therapies Laboratory, CUCAIBA, Province of Buenos Aires Ministry of Health, Transplantation Program, La Plata, Province of Buenos Aires, Argentina.
authors: Karina
authors: K
authors: Martire
authors: Tissue Engineering, Regenerative Medicine and Cell Therapies Laboratory, CUCAIBA, Province of Buenos Aires Ministry of Health, Transplantation Program, La Plata, Province of Buenos Aires, Argentina.
authors: Jose Maria
authors: JM
authors: Tau
authors: Tissue Engineering, Regenerative Medicine and Cell Therapies Laboratory, CUCAIBA, Province of Buenos Aires Ministry of Health, Transplantation Program, La Plata, Province of Buenos Aires, Argentina.
authors: Gabriel
authors: G
authors: Orlandi
authors: Tissue Engineering, Regenerative Medicine and Cell Therapies Laboratory, CUCAIBA, Province of Buenos Aires Ministry of Health, Transplantation Program, La Plata, Province of Buenos Aires, Argentina.
authors: Adrian
authors: A
authors: Tarditti
keywords: Burns; Cadaveric; Mesenchymal stem cells; Skin regeneration; Transplantation