title: Synthesis of Pyridazine-Based α-Helix Mimetics.
abstract: A versatile synthesis of pyridazine-based small molecule α-helix mimetics (A) is presented. Modular C-C, C-N, and C-O bond-forming reactions allow for the inclusion of a variety of aliphatic, basic, aromatic, and heteroaromatic side chain moieties. This robust synthesis is suitable for the preparation of small pyridazine-based libraries.
authors: Pfizer Medicine Design , Eastern Point Road, Groton, Connecticut 06340, United States.
authors: Allyn T
authors: AT
authors: Londregan
authors: Pfizer Medicine Design , Eastern Point Road, Groton, Connecticut 06340, United States.
authors: David W
authors: DW
authors: Piotrowski
authors: Pfizer Medicine Design , Eastern Point Road, Groton, Connecticut 06340, United States.
authors: Liuqing
authors: L
authors: Wei
mesh_terms: D032701:Biomimetics; D000072756:Protein Conformation, alpha-Helical; D011724:Pyridazines / Q000138:chemical synthesis* / Q000737:chemistry; D054852:Small Molecule Libraries / Q000138:chemical synthesis* / Q000737:chemistry; D013329:Structure-Activity Relationship
chemical_list: D011724:Pyridazines; D054852:Small Molecule Libraries; C062482:pyridazine
keywords: Minisci reaction; cross coupling; pyridazine; α-helix mimetic