title: Panax Notoginseng Saponins as a Novel Nature Stabilizer for Poorly Soluble Drug Nanocrystals: A Case Study with Baicalein.
abstract: This study is aimed at seeking a nature saponin-based stabilizer for drug nanosuspensions. A poorly soluble drug (baicalein, BCL) was used as a model drug. BCL nanosuspensions with particle size of 156 nm were prepared by means of homogenization and converted into BCL nanocrystals (BCL-NC) stabilized with panax notoginseng saponins (PNS). It was found that PNS was able to prevent the aggregation of BCL-NS during storage and improve the redispersibility of BCL-NC after freeze-drying and spray-drying, compared with polymer stabilizer PVPK30. The freeze-dried and spray-dried BCL-NC with PNS exhibited excellent performance as evidenced by scanning_electron_microscope (SEM) analysis. It was the reason that PNS possessed the interfacial property (41.69 ± 0.32 mN/m) and electrostatic effect (-40.1 ± 1.6 mV), which could easily adsorb onto the surface of hydrophobic BCL nanocrystals and prevent from its aggregation. It is concluded that PNS can be used as an effective nature stabilizer for production of drug nanocrystals.
authors: Key Laboratory of Modern Preparation of TCM, Ministry of Education, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China. yuanbiaoxie@163.com.
authors: Yuanbiao
authors: Y
authors: Xie
authors: Department of Pharmaceutics, 94th Hospital of People's Liberation Army, Nanchang 330000, China. Yueqinma@126.com.
authors: Yueqin
authors: Y
authors: Ma
authors: Key Laboratory of Modern Preparation of TCM, Ministry of Education, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China. JunnanXuJX@126.com.
authors: Junnan
authors: J
authors: Xu
authors: Key Laboratory of Modern Preparation of TCM, Ministry of Education, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China. kjwxjs2013_2@126.com.
authors: Yang
authors: Y
authors: Liu
authors: Key Laboratory of Modern Preparation of TCM, Ministry of Education, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China. ypfpharm@126.com.
authors: Pengfei
authors: P
authors: Yue
authors: Key Laboratory of Modern Preparation of TCM, Ministry of Education, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China. jxtcmi412@126.com.
authors: Qin
authors: Q
authors: Zheng
authors: Key Laboratory of Modern Preparation of TCM, Ministry of Education, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China. shuotcm@126.com.
authors: Pengyi
authors: P
authors: Hu
authors: Key Laboratory of Modern Preparation of TCM, Ministry of Education, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China. jxtcmi215@126.com.
authors: Ming
authors: M
authors: Yang
mesh_terms: D044950:Flavanones / Q000737:chemistry*; D053758:Nanoparticles / Q000737:chemistry*; D053723:Panax notoginseng / Q000737:chemistry*; D012503:Saponins / Q000737:chemistry*; D012995:Solubility
chemical_list: D044950:Flavanones; D012503:Saponins; C006680:baicalein
keywords: freeze-drying; nanocrystals; nanosuspensions; panax notoginseng saponins; redispersibility; spray-drying