title: Plasminogen deficiency is associated with improved glucose tolerance, and lower DPP-4 activity.
abstract: Plasminogen (Plg), which is the inactive form of plasmin, deficiency enhanced insulin secretion, and was associated with improved oral glucose tolerance in mice. Additionally, Plg deficiency was associated with lower dipeptidyl peptidase-4 (DPP-4) activity, and enhanced glucagons-like peptide-1 (GLP-1) expression. Plg may regulate the DPP-4 activity and the glucose metabolism.
authors: Dept. of Clinical Pathological Biochemistry, Faculty of Pharmaceutical Science, Doshisha Women's Collage of Liberal Arts, 97-1 Kodo Kyotanabe, 610-0395 Kyoto, Japan. Electronic address: ykanno@dwc.doshisha.ac.jp.
authors: Yosuke
authors: Y
authors: Kanno
authors: Dept. of Clinical Pathological Biochemistry, Faculty of Pharmaceutical Science, Doshisha Women's Collage of Liberal Arts, 97-1 Kodo Kyotanabe, 610-0395 Kyoto, Japan.
authors: Akane
authors: A
authors: Sakai
authors: Dept. of Clinical Pathological Biochemistry, Faculty of Pharmaceutical Science, Doshisha Women's Collage of Liberal Arts, 97-1 Kodo Kyotanabe, 610-0395 Kyoto, Japan.
authors: Mei
authors: M
authors: Miyashita
authors: Dept. of Clinical Pathological Biochemistry, Faculty of Pharmaceutical Science, Doshisha Women's Collage of Liberal Arts, 97-1 Kodo Kyotanabe, 610-0395 Kyoto, Japan.
authors: Kaho
authors: K
authors: Tsuchida
authors: Dept. of Physiology, Kinki Univ. School of Med., Osakasayama 589-8511, Osaka, Japan.
authors: Osamu
authors: O
authors: Matsuo
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D050260:Carbohydrate Metabolism; D018819:Dipeptidyl Peptidase 4 / Q000378:metabolism*; D054873:Dipeptidyl-Peptidase IV Inhibitors / Q000627:therapeutic use; D052216:Glucagon-Like Peptide 1 / Q000378:metabolism; D018149:Glucose Intolerance / Q000097:blood*; D005951:Glucose Tolerance Test; D007328:Insulin / Q000378:metabolism; D000078790:Insulin Secretion; D008297:Male; D051379:Mice; D018345:Mice, Knockout; D010958:Plasminogen / Q000172:deficiency*
chemical_list: D001786:Blood Glucose; D054873:Dipeptidyl-Peptidase IV Inhibitors; D007328:Insulin; D052216:Glucagon-Like Peptide 1; D010958:Plasminogen; D018819:Dipeptidyl Peptidase 4; C545245:Dpp4 protein, mouse
keywords: DPP-4; Glucose tolerance; Plasminogen