title: Therapeutic Effects of Resveratrol in a Mouse Model of LPS and Cigarette Smoke-Induced COPD.
abstract: This study was designed to examine whether resveratrol exerts the protective effects on LPS and cigarette smoke (LC)-induced COPD in a murine model. In lung histopathological studies, H&E, Masson's trichrome, and AB-PAS staining were performed. The cytokines (IL-6, IL-17, TGF-β, and TNF-α) and inflammatory cells in BALF were determined. The Beclin1 level in the lungs of mouse was analyzed. Compared with the LC-induced mouse, the level of inflammatory cytokines (IL-17, IL-6, TNF-α, and TGF-β) of the BALF in the resveratrol + cigarette smoke-treated mouse had obviously decreased. Histological examination of the lung tissue revealed that the resveratrol treatment attenuated the fibrotic response and mucus hypersecretion. In addition, resveratrol inhibited the expression of the Beclin1 protein in mouse lungs. The presented findings collectively suggest that resveratrol has a therapeutic effect on mouse LC-induced COPD, and its mechanism of action might be related to reducing the production of the Beclin1 protein.
authors: School of Resources, Environmental & Chemical Engineering of Nanchang University, Nanchang, 330031, China.
authors: Jinlong
authors: J
authors: Chen
authors: Medical Experiment Education Department, Medical College of Nanchang University, Nanchang, 330031, China.
authors: Xu
authors: X
authors: Yang
authors: School of Resources, Environmental & Chemical Engineering of Nanchang University, Nanchang, 330031, China.
authors: Weiya
authors: W
authors: Zhang
authors: School of Resources, Environmental & Chemical Engineering of Nanchang University, Nanchang, 330031, China.
authors: Danhua
authors: D
authors: Peng
authors: School of Resources, Environmental & Chemical Engineering of Nanchang University, Nanchang, 330031, China.
authors: Yanan
authors: Y
authors: Xia
authors: School of Resources, Environmental & Chemical Engineering of Nanchang University, Nanchang, 330031, China.
authors: Yi
authors: Y
authors: Lu
authors: Department of Anesthesia, Wenzhou Central Hospital, Wenzhou, 325000, China.
authors: Xiaodong
authors: X
authors: Han
authors: Department of Neurology, Xiangyang Central Hospital, Xiangyang, 441000, China.
authors: Guangjie
authors: G
authors: Song
authors: School of Resources, Environmental & Chemical Engineering of Nanchang University, Nanchang, 330031, China.
authors: Jing
authors: J
authors: Zhu
authors: School of Resources, Environmental & Chemical Engineering of Nanchang University, Nanchang, 330031, China. sirlrp@163.com.
authors: Renping
authors: R
authors: Liu
mesh_terms: D000818:Animals; D000071186:Beclin-1 / Q000096:biosynthesis / Q000187:drug effects; D001992:Bronchoalveolar Lavage Fluid / Q000737:chemistry; D016207:Cytokines / Q000187:drug effects; D008070:Lipopolysaccharides / Q000009:adverse effects; D008168:Lung / Q000378:metabolism / Q000473:pathology; D051379:Mice; D009093:Mucus / Q000187:drug effects / Q000378:metabolism; D029424:Pulmonary Disease, Chronic Obstructive / Q000139:chemically induced / Q000188:drug therapy / Q000209:etiology*; D011658:Pulmonary Fibrosis / Q000188:drug therapy; D000077185:Resveratrol; D012906:Smoke / Q000009:adverse effects*; D013267:Stilbenes / Q000494:pharmacology / Q000627:therapeutic use*
chemical_list: D000071186:Beclin-1; C115010:Becn1 protein, mouse; D016207:Cytokines; D008070:Lipopolysaccharides; D012906:Smoke; D013267:Stilbenes; D000077185:Resveratrol
keywords: COPD; beclin1; mucus hypersecretion; resveratrol