title: Modeling Type 2 Diabetes GWAS Candidate Gene Function in hESCs.
abstract: Type 2 diabetes is a complex polygenic disorder that affects about 1 in 12 adults. In this issue of Cell Stem Cell, Zeng et al. (2016) elegantly combine CRISPR-based gene editing in hESCs with directed β cell differentiation to investigate the functions of genes highlighted by genome-wide association studies (GWAS) for this disease.
authors: Section of Cell Biology and Functional Genomics, Department of Medicine, Imperial Centre for Translational and Experimental Medicine, Hammersmith Hospital Campus, Imperial College London, Du Cane Road, London, W12 0NN, UK. Electronic address: g.rutter@imperial.ac.uk.
authors: Guy A
authors: GA
authors: Rutter
mesh_terms: D002454:Cell Differentiation; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics*; D055106:Genome-Wide Association Study; D000066449:Human Embryonic Stem Cells; D006801:Humans