title: Circulating cell-derived microparticles as biomarkers in cardiovascular disease.
abstract: Cardiovascular diseases (CVDs) are a common cause of death, and a search for biomarkers for risk stratification is warranted. Elevated levels of cell-derived microparticles (MPs) are found in patients with CVD and in groups with risk factors for CVD. Subpopulations of MPs are promising biomarkers for improving risk prediction, as well as monitoring treatment. However, the field has been hampered by technical difficulties, and the ongoing development of sensitive standardized techniques is crucial for implementing MP analyses in the clinic. Large prospective studies are required to establish which MPs are of prognostic value in different patient groups. In this review, we discuss methodological challenges and progress in the field, as well as MP populations that are of interest for further clinical evaluation.
authors: Department of Medical Sciences, Clinical Chemistry, Uppsala University, Sweden.
authors: Åsa
authors: Å
authors: Thulin
authors: Department of Medical Sciences, Cardiology, Uppsala University, Sweden.
authors: Christina
authors: C
authors: Christersson
authors: Department of Medical Sciences, Clinical Chemistry, Uppsala University, Sweden.
authors: Jenny
authors: J
authors: Alfredsson
authors: Department of Medical Sciences, Clinical Chemistry, Uppsala University, Sweden.
authors: Agneta
authors: A
authors: Siegbahn
mesh_terms: D015703:Antigens, CD / Q000378:metabolism; D050197:Atherosclerosis / Q000175:diagnosis / Q000473:pathology; D001281:Atrial Fibrillation / Q000175:diagnosis / Q000473:pathology; D015415:Biomarkers / Q000097:blood*; D002318:Cardiovascular Diseases / Q000175:diagnosis* / Q000473:pathology; D055252:Cell-Derived Microparticles / Q000378:metabolism*; D006333:Heart Failure / Q000175:diagnosis; D006801:Humans; D011379:Prognosis; D012307:Risk Factors; D033081:Shear Strength
chemical_list: D015703:Antigens, CD; D015415:Biomarkers
keywords: atrial fibrillation; biomarkers; cardiovascular disease; heart failure; microparticles; myocardial infarction; stroke