title: Recent advances in different modal imaging-guided photothermal therapy.
abstract: Photothermal therapy (PTT) has recently attracted considerable attention owing to its controllable treatment process, high tumour eradication efficiency and minimal side effects on non-cancer cells. PTT can melt cancerous cells by localising tissue hyperthermia induced by internalised therapeutic agents with a high photothermal conversion efficiency under external laser irradiation. Numerous in vitro and in vivo studies have shown the significant potential of PTT to treat tumours in future practical applications. Unfortunately, the lack of visualisation towards agent delivery and internalisation, as well as imaging-guided comprehensive evaluation of therapeutic outcome, limits its further application. Developments in combined photothermal therapeutic nanoplatforms guided by different imaging modalities have compensated for the major drawback of PTT alone, proving PTT to be a promising technique in biomedical applications. In this review, we introduce recent developments in different imaging modalities including single-modal, dual-modal, triple-modal and even multi-modal imaging-guided PTT, together with imaging-guided multi-functional theranostic nanoplatforms.
authors: Shaanxi Key Laboratory of Natural Products & Chemical Biology, College of Science, Northwest A&F University, Xinong Road 22, Yangling, Shaanxi 712100, China.
authors: Qiwen
authors: Q
authors: Chen
authors: Shaanxi Key Laboratory of Natural Products & Chemical Biology, College of Science, Northwest A&F University, Xinong Road 22, Yangling, Shaanxi 712100, China.
authors: Jia
authors: J
authors: Wen
authors: Shaanxi Key Laboratory of Natural Products & Chemical Biology, College of Science, Northwest A&F University, Xinong Road 22, Yangling, Shaanxi 712100, China.
authors: Hongjuan
authors: H
authors: Li
authors: Shaanxi Key Laboratory of Natural Products & Chemical Biology, College of Science, Northwest A&F University, Xinong Road 22, Yangling, Shaanxi 712100, China.
authors: Yongqian
authors: Y
authors: Xu
authors: State Key Laboratory of Fine Chemicals, School of Chemistry, Dalian University of Technology, No. 2 Linggong Road, Ganjingzi District, Dalian 116023, China.
authors: Fengyu
authors: F
authors: Liu
authors: Shaanxi Key Laboratory of Natural Products & Chemical Biology, College of Science, Northwest A&F University, Xinong Road 22, Yangling, Shaanxi 712100, China. Electronic address: sunsg@nwsuaf.edu.cn.
authors: Shiguo
authors: S
authors: Sun
mesh_terms: D000818:Animals; D003287:Contrast Media; D005544:Forecasting; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000639:trends*; D053758:Nanoparticles / Q000627:therapeutic use*; D017319:Photosensitizing Agents / Q000008:administration & dosage*; D000068936:Theranostic Nanomedicine / Q000639:trends*; D013813:Therapy, Computer-Assisted / Q000639:trends*; D014057:Tomography, X-Ray Computed / Q000639:trends*
chemical_list: D003287:Contrast Media; D017319:Photosensitizing Agents
keywords: Cancer therapy; Modal imaging; Multi-functional theranostic platforms; PTT