title: Severe motor and vocal tics controlled with Sativex®.
abstract: OBJECTIVE
  A single case report on cannabinoid treatment for treatment-resistant Tourette syndrome (TS).
  
  
  METHODS
  Our subject received 10.8 mg Tetrahydocannabinol and 10 mg cannabidiol daily, in the form of two oro-mucosal sprays of 'Sativex®', twice daily. Assessment was pre-treatment and at week one, two, and four during treatment. He completed the Yale Global Tic Severity Scale as a subjective measure, and was videoed at each stage. The videos were objectively rated by two assessors, blind to the stage of treatment, using the Original Rush Videotape Rating Scale.
  
  
  RESULTS
  Both subjective and objective measures demonstrated marked improvement in the frequency and severity of motor and vocal tics post-treatment. There was good interrater reliability of results.
  
  
  CONCLUSIONS
  Our results support previous research suggesting that cannabinoids are a safe and effective treatment for TS and should be considered in treatment-resistant cases. Further studies are needed to substantiate our findings.
authors: Psychiatry Registrar, Department of Psychiatry, Tauranga Hospital, Tauranga, New Zealand.
authors: David
authors: D
authors: Trainor
authors: Psychiatry Registrar, Department of Psychiatry, Tauranga Hospital, Tauranga, New Zealand.
authors: Lois
authors: L
authors: Evans
authors: Consultant Psychiatrist, Department of Psychiatry, Tauranga Hospital, Tauranga, New Zealand rupert.bird@bopdhb.govt.nz.
authors: Rupert
authors: R
authors: Bird
mesh_terms: D000328:Adult; D002185:Cannabidiol / Q000008:administration & dosage*; D013759:Dronabinol / Q000008:administration & dosage*; D004338:Drug Combinations; D006801:Humans; D008297:Male; D011569:Psychiatric Status Rating Scales; D015203:Reproducibility of Results; D012720:Severity of Illness Index; D020323:Tics / Q000503:physiopathology*; D005879:Tourette Syndrome / Q000188:drug therapy*; D016896:Treatment Outcome; D014743:Videotape Recording
chemical_list: D004338:Drug Combinations; D002185:Cannabidiol; D013759:Dronabinol; C587251:nabiximols
keywords: Sativex®; Tetrahydrocannabinol; cannabis; tourette syndrome