title: Translational MR Neuroimaging of Stroke and Recovery.
abstract: Multiparametric magnetic resonance imaging (MRI) has become a critical clinical tool for diagnosing focal ischemic stroke severity, staging treatment, and predicting outcome. Imaging during the acute phase focuses on tissue viability in the stroke vicinity, while imaging during recovery requires the evaluation of distributed structural and functional connectivity. Preclinical MRI of experimental stroke models provides validation of non-invasive biomarkers in terms of cellular and molecular mechanisms, while also providing a translational platform for evaluation of prospective therapies. This brief review of translational stroke imaging discusses the acute to chronic imaging transition, the principles underlying common MRI methods employed in stroke research, and the experimental results obtained by clinical and preclinical imaging to determine tissue viability, vascular remodeling, structural connectivity of major white matter tracts, and functional connectivity using task-based and resting-state fMRI during the stroke recovery process.
authors: Neuroprotection Research Laboratory, Massachusetts General Hospital, Charlestown, MA, USA. etm@nmr.mgh.harvard.edu.|Department of Radiology, Massachusetts General Hospital, Bldg 149 13th Street, Charlestown, MA, 02129, USA. etm@nmr.mgh.harvard.edu.
authors: Emiri T
authors: ET
authors: Mandeville
authors: Neurovascular Research Laboratory, Massachusetts General Hospital, Charlestown, MA, USA.|Department of Radiology, Massachusetts General Hospital, Bldg 149 13th Street, Charlestown, MA, 02129, USA.
authors: Cenk
authors: C
authors: Ayata
authors: Neurovascular Research Laboratory, Massachusetts General Hospital, Charlestown, MA, USA.|Department of Radiology, Massachusetts General Hospital, Bldg 149 13th Street, Charlestown, MA, 02129, USA.
authors: Yi
authors: Y
authors: Zheng
authors: Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, USA.|Department of Radiology, Massachusetts General Hospital, Bldg 149 13th Street, Charlestown, MA, 02129, USA.
authors: Joseph B
authors: JB
authors: Mandeville
mesh_terms: D000818:Animals; D001921:Brain / Q000098:blood supply / Q000000981:diagnostic imaging* / Q000473:pathology / Q000503:physiopathology; D002545:Brain Ischemia / Q000150:complications / Q000000981:diagnostic imaging* / Q000473:pathology / Q000503:physiopathology; D001931:Brain Mapping / Q000379:methods; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D009389:Neovascularization, Pathologic / Q000000981:diagnostic imaging; D059906:Neuroimaging / Q000379:methods*; D049268:Positron-Emission Tomography / Q000379:methods; D020127:Recovery of Function; D020521:Stroke / Q000150:complications / Q000000981:diagnostic imaging* / Q000473:pathology / Q000503:physiopathology; D057170:Translational Research, Biomedical
keywords: Clinical; Experimental; Imaging; MRI; PET; Stroke