title: Nanomedicine to Overcome Current Parkinson's Treatment Liabilities: A Systematic Review.
abstract: Nanoparticles might be produced and manipulated to present a large spectrum of properties. The physicochemical features of the engineered nanomaterials confer to them different features, including the ability to cross the blood-brain barrier. The main objective of this review is to present the state-of-art research in nano manipulation concerning Parkinson's disease (PD). In the past few years, the association of drugs with nanoparticles solidly improved treatment outcomes. We systematically reviewed 28 studies, describing their potential contributions regarding the role of nanomedicine to increase the efficacy of known pharmacological strategies for PD treatment. Data from animal models resulted in the (i) improvement of pharmacological properties, (ii) more stable drug concentrations, (iii) longer half-live and (iv) attenuation of pharmacological adverse effects. As this approach is recent, with many of the described works being published less than 5 years ago, the expectancy is that this knowledge gives support to an improvement in the current clinical methods to the management of PD and other neurodegenerative diseases.
authors: Department of Medicine, University Center of Maringá (UniCesumar), Maringa, Paraná, Brazil.
authors: Gabriel Henrique
authors: GH
authors: Hawthorne
authors: Department of Health Promotion, University Center of Maringá (UniCesumar), Cesumar Institute of Science Technology and Innovation (ICETI), Maringa, Paraná, Brazil. marcelo.bernuci@unicesumar.edu.br.
authors: Marcelo Picinin
authors: MP
authors: Bernuci
authors: Department of Morphology Physiology and Basic Pathology, Dental School of Ribeirão Preto, University of São Paulo, Ribeirao Preto, São Paulo, Brazil.
authors: Mariza
authors: M
authors: Bortolanza
authors: Department of Neurosciences and Behavioral Sciences Ribeirao Preto Medical School, University of São Paulo, Ribeirao Preto, São Paulo, Brazil.
authors: Vitor
authors: V
authors: Tumas
authors: Department of Morphology Physiology and Basic Pathology, Dental School of Ribeirão Preto, University of São Paulo, Ribeirao Preto, São Paulo, Brazil. carol_issy@hotmail.com.
authors: Ana Carolina
authors: AC
authors: Issy
authors: Department of Morphology Physiology and Basic Pathology, Dental School of Ribeirão Preto, University of São Paulo, Ribeirao Preto, São Paulo, Brazil.
authors: Elaine
authors: E
authors: Del-Bel
mesh_terms: D000818:Animals; D000978:Antiparkinson Agents / Q000008:administration & dosage* / Q000009:adverse effects / Q000494:pharmacology*; D002986:Clinical Trials as Topic; D006801:Humans; D050997:Nanomedicine; D053758:Nanoparticles / Q000008:administration & dosage / Q000009:adverse effects; D020734:Parkinsonian Disorders / Q000188:drug therapy* / Q000378:metabolism
chemical_list: D000978:Antiparkinson Agents
keywords: Nanomedicine; Nanoparticles; Nanotechnology; Parkinson’s disease