title: Region-specific roles of the corticotropin-releasing factor-urocortin system in stress.
abstract: Dysregulation of the corticotropin-releasing factor (CRF)-urocortin (UCN) system has been implicated in stress-related psychopathologies such as depression and anxiety. It has been proposed that CRF-CRF receptor type 1 (CRFR1) signalling promotes the stress response and anxiety-like behaviour, whereas UCNs and CRFR2 activation mediate stress recovery and the restoration of homeostasis. Recent findings, however, provide clear evidence that this view is overly simplistic. Instead, a more complex picture has emerged that suggests that there are brain region- and cell type-specific effects of CRFR signalling that are influenced by the individual's prior experience and that shape molecular, cellular and ultimately behavioural responses to stressful challenges.
authors: Department of Neurobiology, Weizmann Institute of Science, Rehovot 7610001, Israel.|Department of Stress Neurobiology and Neurogenetics, Max Planck Institute of Psychiatry, 80804 Munich, Germany.|Department of Cognitive Neuroscience, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Centre, 6500 HB Nijmegen, The Netherlands.
authors: Marloes J A G
authors: MJ
authors: Henckens
authors: Department of Stress Neurobiology and Neurogenetics, Max Planck Institute of Psychiatry, 80804 Munich, Germany.
authors: Jan M
authors: JM
authors: Deussing
authors: Department of Neurobiology, Weizmann Institute of Science, Rehovot 7610001, Israel.|Department of Stress Neurobiology and Neurogenetics, Max Planck Institute of Psychiatry, 80804 Munich, Germany.
authors: Alon
authors: A
authors: Chen
mesh_terms: D000818:Animals; D001007:Anxiety / Q000503:physiopathology*; D003346:Corticotropin-Releasing Hormone / Q000502:physiology*; D003863:Depression / Q000503:physiopathology*; D006801:Humans; D008959:Models, Neurological; D018019:Receptors, Corticotropin-Releasing Hormone / Q000502:physiology*; D013315:Stress, Psychological / Q000503:physiopathology*; D054832:Urocortins / Q000502:physiology*
chemical_list: D018019:Receptors, Corticotropin-Releasing Hormone; D054832:Urocortins; D003346:Corticotropin-Releasing Hormone