title: Are cytotoxic effector cells changes in peripheral blood of patients with Sjögren's syndrome related to persistent virus infection: Suggestions and conundrums.
abstract: Etiology of Sjögren's syndrome (SS) is still unknown, but there is strong evidence that certain pathogens of bacterial or viral origin can incite autoimmune response. The aim of this study was to quantitatively evaluate changes of the main cell populations (dendritic cells, natural killer, natural killer T and cytotoxic T lymphocytes) presumably participating in virus clearance in peripheral blood of patients with primary SS (pSS). In analyzing cytotoxic T lymphocytes (CTL) populations we observed alterations in the frequency of highly cytotoxic effector CD8high/57+/27-/45RA+, less cytotoxic CD8high/57-/27-/45RA+effector cells and cytotoxic memory CD8high/57+/27+/45RA-effector cells. We found a decrease of conventional dendritic cells (cDC) population in peripheral blood of pSS patients. It is possible that, a decrease of effector CTL and cDC, accompanied by increase of transitory phenotype memory CTL in peripheral blood of pSS patients may be associated with viral etiopathogenesis of Sjögren's syndrome.
authors: Department of Immunology, State Research Institute Centre for Innovative Medicine, Santariskiu st. 5, LT-08406 Vilnius, Lithuania.
authors: Ieva
authors: I
authors: Narkeviciute
authors: Department of Immunology, State Research Institute Centre for Innovative Medicine, Santariskiu st. 5, LT-08406 Vilnius, Lithuania.
authors: Gintaras
authors: G
authors: Sudzius
authors: Department of Innovative Diagnostic, Treatment and Health Monitoring Technology, State Research Institute Centre for Innovative Medicine, Santariskiu st. 5, LT-08406 Vilnius, Lithuania.
authors: Diana
authors: D
authors: Mieliauskaite
authors: Department of Regenerative Medicine, State Research Institute Centre for Innovative Medicine, Santariskiu st. 5, LT-08406 Vilnius, Lithuania.
authors: Zygmunt
authors: Z
authors: Mackiewicz
authors: Department of Innovative Diagnostic, Treatment and Health Monitoring Technology, State Research Institute Centre for Innovative Medicine, Santariskiu st. 5, LT-08406 Vilnius, Lithuania; Center of Rheumatology, Vilnius University, Santariskiu st. 2, LT-08406 Vilnius, Lithuania.
authors: Irena
authors: I
authors: Butrimiene
authors: Department of Immunology, State Research Institute Centre for Innovative Medicine, Santariskiu st. 5, LT-08406 Vilnius, Lithuania.
authors: Rita
authors: R
authors: Viliene
authors: Department of Immunology, State Research Institute Centre for Innovative Medicine, Santariskiu st. 5, LT-08406 Vilnius, Lithuania; Department of Chemistry and Bioengineering, Faculty of Fundamental Sciences, Vilnius Gediminas Technical University, Saulėtekio al. 11, LT-10223 Vilnius, Lithuania. Electronic address: i.dumalakiene@imcentras.lt.
authors: Irena
authors: I
authors: Dumalakiene
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015703:Antigens, CD / Q000378:metabolism; D001773:Blood Cells / Q000276:immunology*; D003713:Dendritic Cells / Q000276:immunology*; D005260:Female; D006801:Humans; D007156:Immunologic Memory; D016130:Immunophenotyping; D008297:Male; D008875:Middle Aged; D012859:Sjogren's Syndrome / Q000276:immunology*; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology*; D014777:Virus Diseases / Q000276:immunology*
chemical_list: D015703:Antigens, CD
keywords: Conventional dendritic cells; Cytotoxic T lymphocytes; Natural killer T cells; Natural killers; Plasmacytoid dendritic cells; Sjögren’s syndrome