title: Conjugate addition-enantioselective protonation reactions.
abstract: The addition of nucleophiles to electron-deficient alkenes represents one of the more general and commonly used strategies for the convergent assembly of more complex structures from simple precursors. In this review the addition of diverse protic and organometallic nucleophiles to electron-deficient alkenes followed by enantioselective protonation is summarized. Reactions are first categorized by the type of electron-deficient alkene and then are further classified according to whether catalysis is achieved with chiral Lewis acids, organocatalysts, or transition metals.
authors: Department of Chemistry, Yale University, 225 Prospect Street, New Haven, CT 06520, USA.
authors: James P
authors: JP
authors: Phelan
authors: Department of Chemistry, Yale University, 225 Prospect Street, New Haven, CT 06520, USA.
authors: Jonathan A
authors: JA
authors: Ellman
keywords: asymmetric catalysis; conjugate addition; enantioselective protonation; enolate