title: Patterning nanofibrils through the templated growth of multiple modified amyloid peptides.
abstract: There has been considerable interest in the patterning of functionalized nanowires because of the potential applications of these materials to the construction of nanodevices. A variety of biomolecular building blocks containing amyloid peptides have been used to functionalize nanowires. However, the patterning of self-assembled nanowires can be challenging because of the difficulties associated with controlling the self-assembly of these functionalized building blocks. Herein, we present a versatile approach for the patterning of nanowires based on the combination of templated fibril growth with a versatile functionalization method using our structure-controllable amyloid peptides (SCAPs). Using this approach, we have succeeded in the formation of multi-type nanowires with tandem domain structures in high yields. Given that the mixing-SCAP method can lead to the formation of tandem fibrils, it is noteworthy that our method allowed us to control the initiation of fibril formation from the gold nanoparticles, which were attached to a short fibril as initiation points. This approach could be used to prepare a wide variety of fibril patterns, and therefore holds great potential for the development of novel self-assembled nanodevices.
authors: Department of Chemistry, Faculty of Science, Hokkaido University, N10 W8, Kita-ku, Sapporo 060-0810, Japan.
authors: Hiroki
authors: H
authors: Sakai
authors: Department of Chemistry, Faculty of Science, Hokkaido University, N10 W8, Kita-ku, Sapporo 060-0810, Japan.
authors: Ken
authors: K
authors: Watanabe
authors: Department of Chemistry, Faculty of Science, Hokkaido University, N10 W8, Kita-ku, Sapporo 060-0810, Japan.
authors: Fuki
authors: F
authors: Kudoh
authors: Department of Chemistry, Faculty of Science, Hokkaido University, N10 W8, Kita-ku, Sapporo 060-0810, Japan.
authors: Rui
authors: R
authors: Kamada
authors: Department of Chemistry, Faculty of Science, Hokkaido University, N10 W8, Kita-ku, Sapporo 060-0810, Japan.
authors: Yoshiro
authors: Y
authors: Chuman
authors: Department of Chemistry, Faculty of Science, Hokkaido University, N10 W8, Kita-ku, Sapporo 060-0810, Japan.
authors: Kazuyasu
authors: K
authors: Sakaguchi
mesh_terms: D000538:Aluminum Silicates / Q000737:chemistry; D000595:Amino Acid Sequence; D000682:Amyloid / Q000737:chemistry; D016229:Amyloid beta-Peptides / Q000737:chemistry* / Q000378:metabolism; D006046:Gold / Q000737:chemistry; D053768:Metal Nanoparticles / Q000737:chemistry; D018625:Microscopy, Atomic Force; D008856:Microscopy, Fluorescence; D053770:Nanowires / Q000737:chemistry*
chemical_list: D000538:Aluminum Silicates; D000682:Amyloid; D016229:Amyloid beta-Peptides; D006046:Gold; C011934:mica