title: The LSP1 rs3817198 T > C polymorphism contributes to increased breast cancer risk: a meta-analysis of twelve studies.
abstract: The association between the LSP1 rs3817198 T > C polymorphism and breast cancer risk has been widely investigated, but remains controversial. We therefore undertook a comprehensive meta-analysis to provide a high-quality evaluation of this association. A literature search was performed among Pubmed, EMBASE and Chinese National Knowledge Infrastructure (CNKI) databases prior to July 31, 2016, and the strength of the association between the LSP1 rs3817198 T > C polymorphism and breast cancer risk was assessed based on odds ratio (OR) and 95% confidence interval (95% CI). In total, 12 studies with 50,525 cases and 54,302 controls were included. Pooled risk estimates indicated a significant association between the LSP1 rs3817198 T > C polymorphism and breast cancer risk. Analysis of cases stratified based on ethnicity suggested that the association was significant in both Caucasian and Asian populations. Stratification based on source of controls revealed an association only in population-based studies. These findings indicate the LSP1 rs3817198 T > C polymorphism is associated with increased risk of breast cancer, especially in Caucasian and Asian populations. Large, well-designed studies with different ethnicities are still needed to verify our findings.
authors: Department of Biological and Environmental Engineering, Changsha University, Changsha 410003, Hunan, China.|College of Animal Science and Technology of Hunan Agriculture University, Changsha 410128, Hunan, China.
authors: Jianzhou
authors: J
authors: Tang
authors: Department of Microbiology and Immunology, Medical School of Jishou University, Jishou 416000, Hunan, China.
authors: Hui
authors: H
authors: Li
authors: Institute of Medical Sciences, Medical School of Jishou University, Jishou 416000, Hunan, China.
authors: Jiashun
authors: J
authors: Luo
authors: Hunan Guangxiu Hospital, Changsha 410002, Hunan, China.
authors: Hua
authors: H
authors: Mei
authors: Department of Biological and Environmental Engineering, Changsha University, Changsha 410003, Hunan, China.
authors: Liang
authors: L
authors: Peng
authors: College of Animal Science and Technology of Hunan Agriculture University, Changsha 410128, Hunan, China.
authors: Xiaojie
authors: X
authors: Li
mesh_terms: D044466:Asian People; D001943:Breast Neoplasms / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008840:Microfilament Proteins / Q000235:genetics*; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D044465:White People
chemical_list: C489183:LSP1 protein, human; D008840:Microfilament Proteins
keywords: LSP1; breast cancer; meta-analysis; risk