title: Intracranial Rosai-Dorfman disease.
abstract: Rosai-Dorfman disease (RDD) is a rare histioproliferative disorder that only occasionally involves the central nervous system. We present the diagnosis and treatment of five patients with intracranial RDD. The patients were preoperatively misdiagnosed as meningioma or eosinophilic granuloma. All five patients were treated by total or subtotal surgical resection and none of them experienced recurrence. Histopathological examination showed a characteristic emperipolesis, the lymphocytes were engulfed in the S-100 protein and CD68 positive histiocytes, with negative expression of CD1a. Preoperative diagnosis of intracranial RDD is still challenging because the lesion is usually a dural-based lesion that mimics a meningioma. Surgical resection is an effective treatment and radiotherapy, steroid and chemotherapy has not demonstrated reliable therapeutic efficiency.
authors: Department of Neurosurgery, Beijing Electric Power Hospital, Capital Medical University, Beijing, China.
authors: Bo Yuan
authors: BY
authors: Huang
authors: Department of Neurosurgery, Beijing Electric Power Hospital, Capital Medical University, Beijing, China.
authors: Miao
authors: M
authors: Zong
authors: College of Traditional Chinese Medicine, Capital Medical University, Beijing, China.
authors: Wen Jing
authors: WJ
authors: Zong
authors: Department of Neurosurgery, Beijing Tian Tan Hospital, Capital Medical University, Beijing, China. Electronic address: 525111209@qq.com.
authors: Yan Hui
authors: YH
authors: Sun
authors: Department of Neurosurgery, Beijing Tian Tan Hospital, Capital Medical University, Beijing, China.
authors: Hua
authors: H
authors: Zhang
authors: Integrated Traditional and Western Medicine Hospital of Hubei Province, Department of Neurosurgery, Wu Han, China.
authors: Hong Bo
authors: HB
authors: Zhang
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D003937:Diagnosis, Differential; D003951:Diagnostic Errors; D005260:Female; D005500:Follow-Up Studies; D006644:Histiocytes / Q000473:pathology; D015618:Histiocytosis, Sinus / Q000000981:diagnostic imaging* / Q000601:surgery*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D035583:Rare Diseases / Q000000981:diagnostic imaging* / Q000601:surgery*; D012189:Retrospective Studies; D016896:Treatment Outcome
keywords: Histioproliferative disease; Intracranial; Rosai–Dorfman disease