title: Bundling potent natural toxin cantharidin within platinum (IV) prodrugs for liposome drug delivery and effective malignant neuroblastoma treatment.
abstract: Neuroblastoma (NB) is one of the most commonly seen malignancies in childhood and infancy. Cantharidin is a highly potent natural toxin that possesses potent anti-tumor properties on various cancers including NB. However, exposure to cantharidin can cause severe chemical burns and application of cantharidin for cancer therapy is limited. Here we report a strategy of bundling cantharidin within a hybrid platinum (IV) prodrug conjugate. This hydrophobic drug conjugate, ie, CanPt can be further formulated into liposome for drug delivery to minimize the exposure of cantharidin to normal cells for efficient chemotherapeutic agent against NB.
authors: Department of Neurosurgery, South Campus, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
authors: Xi
authors: X
authors: Yang
authors: Department of Nephrology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
authors: Jun
authors: J
authors: Tong
authors: Department of Neurosurgery, South Campus, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
authors: Liemei
authors: L
authors: Guo
authors: Department of Neurosurgery, South Campus, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
authors: Zhongrun
authors: Z
authors: Qian
authors: Key Laboratory of Bio-Medical Diagnostics, Suzhou Institute of Biomedical Engineering, Chinese Academy of Sciences, Suzhou, China.
authors: Qixian
authors: Q
authors: Chen
authors: State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, China. Electronic address: Ruoguqix@gmail.com.
authors: Ruogu
authors: R
authors: Qi
authors: Department of Neurosurgery, South Campus, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. Electronic address: qiuzhoub@hotmail.com.
authors: Yongming
authors: Y
authors: Qiu
mesh_terms: D000818:Animals; D002193:Cantharidin / Q000008:administration & dosage*; D045744:Cell Line, Tumor; D004337:Drug Carriers / Q000737:chemistry*; D065546:Drug Liberation; D004354:Drug Screening Assays, Antitumor; D005260:Female; D008081:Liposomes / Q000737:chemistry*; D051379:Mice; D008807:Mice, Inbred BALB C; D058726:Nanoconjugates / Q000737:chemistry; D009447:Neuroblastoma / Q000188:drug therapy*; D010984:Platinum / Q000008:administration & dosage*; D011355:Prodrugs / Q000008:administration & dosage*
chemical_list: D004337:Drug Carriers; D008081:Liposomes; D058726:Nanoconjugates; D011355:Prodrugs; D010984:Platinum; D002193:Cantharidin
keywords: Cantharidin; Drug delivery; Liposome; Natural toxin; Neuroblastoma; Picoplatin