title: Pharmacological Actions of Glucagon-Like Peptide-1, Gastric Inhibitory Polypeptide, and Glucagon.
abstract: Glucagon family of peptide hormones is a group of structurally related brain-gut peptides that exert their pleiotropic actions through interactions with unique members of class B1 G protein-coupled receptors (GPCRs). They are key regulators of hormonal homeostasis and are important drug targets for metabolic disorders such as type-2 diabetes mellitus (T2DM), obesity, and dysregulations of the nervous systems such as migraine, anxiety, depression, neurodegeneration, psychiatric disorders, and cardiovascular diseases. The current review aims to provide a detailed overview of the current understanding of the pharmacological actions and therapeutic advances of three members within this family including glucagon-like peptide-1 (GLP-1), gastric inhibitory polypeptide (GIP), and glucagon.
authors: School of Biological Sciences, University of Hong Kong, Hong Kong, China.
authors: R
authors: R
authors: Sekar
authors: School of Biological Sciences, University of Hong Kong, Hong Kong, China.
authors: K
authors: K
authors: Singh
authors: School of Biological Sciences, University of Hong Kong, Hong Kong, China.
authors: A W R
authors: AW
authors: Arokiaraj
authors: School of Biological Sciences, University of Hong Kong, Hong Kong, China. Electronic address: bkcc@hku.hk.
authors: B K C
authors: BK
authors: Chow
mesh_terms: D000818:Animals; D005260:Female; D005749:Gastric Inhibitory Polypeptide / Q000009:adverse effects / Q000494:pharmacology* / Q000627:therapeutic use; D005934:Glucagon / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D052216:Glucagon-Like Peptide 1 / Q000009:adverse effects / Q000494:pharmacology* / Q000627:therapeutic use; D006801:Humans; D008297:Male
chemical_list: D005749:Gastric Inhibitory Polypeptide; D052216:Glucagon-Like Peptide 1; D005934:Glucagon
keywords: gastric inhibitory polypeptide; glucagon; glucagon-like peptide-1; pharmacology; type-2 diabetes mellitus