title: The function of homeobox genes and lncRNAs in cancer.
abstract: Recently, the homeobox (HOX) gene family has been reported as a factor in tumorigenesis. In the human genome, the HOX gene family contains 4 clusters with 39 genes and multiple transcripts. Mutation or abnormal expression of genes is responsible for developmental disorders. In addition, changes in the levels and activation of certain HOX genes has been associated with the development of cancer. Long non-coding RNAs (lncRNAs) have also been identified to serve critical functions in cancer. Although a limited number of lncRNAs have been previously investigated, the list of functional lncRNA genes has recently grown. Two of the most important and well-studied lncRNAs and HOX transcript genes are HOX transcript antisense RNA (HOTAIR) and HOXA distal transcript antisense RNA (HOTTIP). The present study aimed to review not only the function of the HOTAIR and HOTTIP genes in certain forms of cancer, but also to review other HOX genes and protein functions in cancer, particularly HOX family genes associated with lncRNAs.
authors: The Liver Center of Fujian Province, Fujian Medical University, Fuzhou, Fujian 350025, P.R. China; The United Innovation Platform of Mengchao, Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou, Fujian 350025, P.R. China.
authors: Yingchao
authors: Y
authors: Wang
authors: Department of Experimental Medicine, Fuzhou General Hospital, Fuzhou, Fujian 350025, P.R. China.
authors: Yuan
authors: Y
authors: Dang
authors: The Liver Center of Fujian Province, Fujian Medical University, Fuzhou, Fujian 350025, P.R. China; The United Innovation Platform of Mengchao, Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou, Fujian 350025, P.R. China.
authors: Jingfeng
authors: J
authors: Liu
authors: Department of Experimental Medicine, Fuzhou General Hospital, Fuzhou, Fujian 350025, P.R. China.
authors: Xiaojuan
authors: X
authors: Ouyang
keywords: homeobox A; homeobox genes; proliferation; transcript