title: Sonographic Pulmonary Abnormalities in Fetuses With Hypoplastic Left Heart Syndrome and Intact Atrial Septum Undergoing Attempted Atrial Septostomy In Utero.
abstract: Fetuses with hypoplastic left heart syndrome (HLHS) and intact atrial septum are a particular subset of HLHS neonates with high perinatal mortality. The reported mortality in these patients is 50% to 70%, even with prenatal diagnosis. Prenatal left atrial and pulmonary venous hypertension results in abnormal pulmonary vascular and parenchymal development. The goal of this study was to compare the sonographic appearance of the lungs in fetuses with HLHS/intact atrial septum to neonatal outcome and/or pathology in cases where in utero intervention was performed to open the atrial septum. We found that lung inhomogeneity on ultrasound corresponded to peripheral lymphatic dilatation at autopsy and was associated with a dismal prognosis even when in utero intervention was successful.
authors: *Department of Radiology, Brigham and Women's Hospital; Departments of †Cardiology and ‡Pathology, Boston Children's Hospital; and §Department of Obstetrics and Gynecology, Brigham and Women's Hospital, Boston, MA.
authors: Meaghan M
authors: MM
authors: Mackesy
authors: Brian T
authors: BT
authors: Kalish
authors: Wayne
authors: W
authors: Tworetzky
authors: Stephen
authors: S
authors: Sanders
authors: Alyaa
authors: A
authors: Al-Ibraheemi
authors: Louise
authors: L
authors: Wilkins-Haug
authors: James
authors: J
authors: Lock
authors: Audrey
authors: A
authors: Marshall
authors: Carol B
authors: CB
authors: Benson
mesh_terms: D054087:Atrial Septum / Q000000981:diagnostic imaging* / Q000196:embryology / Q000601:surgery*; D005260:Female; D005318:Fetal Heart / Q000000981:diagnostic imaging / Q000196:embryology / Q000601:surgery; D006801:Humans; D018636:Hypoplastic Left Heart Syndrome / Q000150:complications*; D008168:Lung / Q000002:abnormalities* / Q000000981:diagnostic imaging / Q000196:embryology*; D011247:Pregnancy; D016216:Ultrasonography, Prenatal / Q000379:methods*