title: Microstructural abnormalities of uncinate fasciculus as a function of impaired cognition in schizophrenia: A DTI study.
abstract: Neuropsychological studies have reported that attention, memory, language, motor and emotion processing are impaired in schizophrenia. It is known that schizophrenia involves structural alterations in the white matter of brain that contribute to the pathophysiology of the disorder. Uncinate fasciculus (UNC), a bundle of white matter fibres, plays an important role in the pathology of this disorder and involved in cognitive functions such as memory, language and emotion processing. Therefore, the present study aimed to investigate microstructural changes in UNC fibre in schizophrenia patients relative to controls and its correlation with neuropsychological scores. Diffusion tensor imaging (DTI) and Hindi version of Penn Computerised Neuropsychological Battery test was performed in 14 schizophrenia patients and 14 controls. DTI measures [fractional anisotropy (FA) and mean diffusivity (MD)] from UNC fibre were calculated and a comparison was made between patients and controls. Pearson's correlation was performed between neuropsychological scores and DTI measures.Schizophrenia patients showed significantly reduced FA values in UNC fibre compared to controls. In schizophrenia patients, a positive correlation of attention, spatial memory, sensorimotor dexterity and emotion with FA was observed. These findings suggest that microstructural changes in UNC fibre may contribute to underlying dysfunction in the cognitive functions associated with schizophrenia.
authors: NMR Research Centre, Institute of Nuclear Medicine and Allied Sciences (INMAS), DRDO, New Delhi, India.
authors: Sadhana
authors: S
authors: Singh
authors: Kavita
authors: K
authors: Singh
authors: Richa
authors: R
authors: Trivedi
authors: Satnam
authors: S
authors: Goyal
authors: Prabhjot
authors: P
authors: Kaur
authors: Namita
authors: N
authors: Singh
authors: Triptish
authors: T
authors: Bhatia
authors: Smita N
authors: SN
authors: Deshpande
authors: Subash
authors: S
authors: Khushu
mesh_terms: D000328:Adult; D060825:Cognitive Dysfunction / Q000000981:diagnostic imaging* / Q000503:physiopathology; D056324:Diffusion Tensor Imaging; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012559:Schizophrenia / Q000000981:diagnostic imaging* / Q000503:physiopathology; D066127:White Matter / Q000473:pathology / Q000648:ultrastructure*