title: Two-weeks-sustained unresponsiveness by oral immunotherapy using microwave heated cow's milk for children with cow's milk allergy.
abstract: BACKGROUND
  Several studies have reported that oral immunotherapy (OIT) is effective for children with cow's milk (CM) allergy. These studies reported the efficacy of OIT in terms of desensitization, but did not describe sustained unresponsiveness to CM. The aim of this study was to evaluate the efficacy of the OIT protocol using microwave heated cow's milk (MH-CM) in terms of 2-weeks-sustained unresponsiveness (2-weeks-SU) and safety.
  
  
  METHODS
  Forty-eight children were enrolled in this study. Thirty-one children agreed to receive rush OIT using MH-CM (the OIT group) and another 17 children who did not want to receive rush OIT formed the untreated group. Rates of desensitization and 2-weeks-sustained unresponsiveness were compared between the two groups at 1 year after the start of OIT. We followed up these rates and safety data for another year and for longer in the OIT group.
  
  
  RESULTS
  No children in the untreated group did not pass an open food challenge to CM. Of the 31 children in the OIT group, 14 (P = 0.002) achieved desensitization, and 8 (P = 0.036) achieved 2-weeks-SU to CM at 1 year from the start of OIT. Two years after the start of OIT, both the rate of desensitization and the rate of 2-weeks-SU in the OIT group significantly increased compared with the rates at 1 year (P = 0.025 and P = 0.008 respectively).
  
  
  CONCLUSIONS
  The rush OIT protocol using MH-CM was effective at inducing 2-weeks-SU s to CM and had a good safety profile in children with CM allergy. Trial registration Approval number: 324, Registered 3 February 2009.
authors: Department of Pediatrics, Kansai Medical University, 2-5-1 Shin-machi, Hirakata, Osaka Japan.
authors: Masaya
authors: M
authors: Takahashi
authors: Department of Pediatrics, Kansai Medical University, 2-5-1 Shin-machi, Hirakata, Osaka Japan.
authors: Shoichiro
authors: S
authors: Taniuchi
authors: Department of Pediatrics, Kansai Medical University, 2-5-1 Shin-machi, Hirakata, Osaka Japan.
authors: Kazuhiko
authors: K
authors: Soejima
authors: Department of Pediatrics, Kansai Medical University, 2-5-1 Shin-machi, Hirakata, Osaka Japan.
authors: Yasuko
authors: Y
authors: Hatano
authors: Department of Pediatrics, Kansai Medical University, 2-5-1 Shin-machi, Hirakata, Osaka Japan.
authors: Sohsaku
authors: S
authors: Yamanouchi
authors: Department of Pediatrics, Kansai Medical University, 2-5-1 Shin-machi, Hirakata, Osaka Japan.
authors: Kazuanri
authors: K
authors: Kaneko
keywords: Cow’s milk specific IgE; Food allergy; Microwave heated cow’s milk; Oral immunotherapy; Sustained unresponsiveness