title: Changes in the Composition of Adiponectin Fractions over a 3-Year Period in Children: A Population-Based Cohort Study.
abstract: Little information is available regarding changes in adiponectin fractions. The objective of this study was to examine changes in the composition of differing adiponectin fractions using a population-based, prospective pediatric cohort.
  
  
  
  A total of 358 fourth graders (9-10 years old) from Ina town in Saitama, Japan, were followed up for 3 years. BMI and total adiponectin (TAD), high-molecular weight adiponectin (HAD), medium-molecular weight adiponectin, and low-molecular weight adiponectin levels were measured in these subjects at baseline and at the end of the follow-up.
  
  
  
  Of the fourth graders participating in the study, 326 (172 boys and 154 girls; follow-up rate, 91.1%) became available for follow-up. No significant changes were observed in TAD values after 3 years. HAD values were significantly decreased in both the boys (2.4 to 2.2 μg/mL: p < 0.001) and girls (3.1 to 2.7 μg/mL: p = 0.005). All values in the parameters examined at baseline and after 3 years were significantly correlated. A negative correlation was found between the ratios of follow-up compared to baseline values for BMI and those for TAD (boys, r = -0.322, p < 0.001; girls, r = -0.433, p < 0.001) as well as those for HAD (boys, r = -0.353, p < 0.001; girls, r = -0.351, p < 0.001).
  
  
  
  HAD had the most robust correlation between its values at baseline and those after 3 years in both boys and girls. The changes in HAD also had the most robust correlation between the changes in BMI in 3 years.
authors: 1 Division of Diabetes, Metabolism, and Endocrinology, Department of Internal Medicine, Jikei University School of Medicine , Tokyo, Japan .|2 Graduate School of Public Health, University of Pittsburgh , Pittsburgh, PA.
authors: Rimei
authors: R
authors: Nishimura
authors: 1 Division of Diabetes, Metabolism, and Endocrinology, Department of Internal Medicine, Jikei University School of Medicine , Tokyo, Japan .
authors: Hironari
authors: H
authors: Sano
authors: 3 Department of Public Health, Showa University School of Medicine , Tokyo, Japan .
authors: Takako
authors: T
authors: Shirasawa
authors: 1 Division of Diabetes, Metabolism, and Endocrinology, Department of Internal Medicine, Jikei University School of Medicine , Tokyo, Japan .
authors: Toru
authors: T
authors: Matsudaira
authors: 1 Division of Diabetes, Metabolism, and Endocrinology, Department of Internal Medicine, Jikei University School of Medicine , Tokyo, Japan .
authors: Yumi
authors: Y
authors: Miyashita
authors: 3 Department of Public Health, Showa University School of Medicine , Tokyo, Japan .
authors: Hirotaka
authors: H
authors: Ochiai
authors: 3 Department of Public Health, Showa University School of Medicine , Tokyo, Japan .
authors: Akatsuki
authors: A
authors: Kokaze
authors: 4 Jikei University School of Medicine , Tokyo, Japan .
authors: Naoko
authors: N
authors: Tajima
authors: 1 Division of Diabetes, Metabolism, and Endocrinology, Department of Internal Medicine, Jikei University School of Medicine , Tokyo, Japan .
authors: Kazunori
authors: K
authors: Utsunomiya
mesh_terms: D052242:Adiponectin / Q000097:blood*; D000293:Adolescent; D000886:Anthropometry; D044466:Asian People; D015992:Body Mass Index; D002648:Child; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007564:Japan / Q000453:epidemiology; D008297:Male; D056128:Obesity, Abdominal / Q000097:blood* / Q000150:complications / Q000453:epidemiology; D011446:Prospective Studies; D012307:Risk Factors
chemical_list: D052242:Adiponectin