title: Gene Expression and Proteome Analysis as Sources of Biomarkers in Basal Cell Carcinoma.
abstract: Basal cell carcinoma (BCC) is the world's leading skin cancer in terms of frequency at the moment and its incidence continues to rise each year, leading to profound negative psychosocial and economic consequences. UV exposure is the most important environmental factor in the development of BCC in genetically predisposed individuals, this being reflected by the anatomical distribution of lesions mainly on sun-exposed skin areas. Early diagnosis and prompt management are of crucial importance in order to prevent local tissue destruction and subsequent disfigurement. Although various noninvasive or minimal invasive techniques have demonstrated their utility in increasing diagnostic accuracy of BCC and progress has been made in its treatment options, recurrent, aggressive, and metastatic variants of BCC still pose significant challenge for the healthcare system. Analysis of gene expression and proteomic profiling of tumor cells and of tumoral microenvironment in various tissues strongly suggests that certain molecules involved in skin cancer pathogenic pathways might represent novel predictive and prognostic biomarkers in BCC.
authors: Department of Dermatology and Allergology, Elias Emergency University Hospital, 011461 Bucharest, Romania.
authors: Mihai
authors: 0000-0002-5438-0817
authors: M
authors: Lupu
authors: Department of Physiology, "Carol Davila" University of Medicine and Pharmacy, 050474 Bucharest, Romania; Department of Dermatology, "Prof. N. C. Paulescu" National Institute of Diabetes, Nutrition and Metabolic Diseases, 020475 Bucharest, Romania.
authors: Constantin
authors: 0000-0003-4530-7965
authors: C
authors: Caruntu
authors: Dermatology Research Laboratory, "Carol Davila" University of Medicine and Pharmacy, 050474 Bucharest, Romania.
authors: Mihaela Adriana
authors: MA
authors: Ghita
authors: Department of Dermatology and Allergology, Elias Emergency University Hospital, 011461 Bucharest, Romania.
authors: Vlad
authors: 0000-0002-5671-9378
authors: V
authors: Voiculescu
authors: Department of Physiology, "Carol Davila" University of Medicine and Pharmacy, 050474 Bucharest, Romania.
authors: Suzana
authors: S
authors: Voiculescu
authors: Department of Physiology, "Carol Davila" University of Medicine and Pharmacy, 050474 Bucharest, Romania.
authors: Adrian E
authors: AE
authors: Rosca
authors: Department of Oral and Maxillofacial Surgery, "Carol Davila" Central Military Emergency Hospital, 010825 Bucharest, Romania.
authors: Ana
authors: 0000-0003-4200-3069
authors: A
authors: Caruntu
authors: Department of Oral and Maxillofacial Surgery, "Carol Davila" Central Military Emergency Hospital, 010825 Bucharest, Romania.
authors: Liliana
authors: L
authors: Moraru
authors: Department of Plastic and Reconstructive Surgery, "Bagdasar Arseni" Clinical Emergency Hospital, 041915 Bucharest, Romania.
authors: Iris Maria
authors: 0000-0001-7702-448X
authors: IM
authors: Popa
authors: Department of Biochemistry, Faculty of Dental Medicine, University of Medicine and Pharmacy "Carol Davila", 050474 Bucharest, Romania.
authors: Bogdan
authors: 0000-0002-7565-9964
authors: B
authors: Calenic
authors: Department of Biochemistry, Faculty of Dental Medicine, University of Medicine and Pharmacy "Carol Davila", 050474 Bucharest, Romania.
authors: Maria
authors: M
authors: Greabu
authors: Gade Laboratory for Pathology and Centre for Cancer Biomarkers (CCBio), Department of Clinical Medicine, University of Bergen, 5021 Bergen, Norway; Department of Pathology, Haukeland University Hospital, 5021 Bergen, Norway.
authors: Daniela Elena
authors: 0000-0001-7673-0358
authors: DE
authors: Costea
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000032:analysis*; D002280:Basal Cell Carcinoma / Q000235:genetics / Q000378:metabolism / Q000473:pathology*; D020869:Gene Expression Profiling; D006801:Humans; D020543:Proteome / Q000032:analysis*; D040901:Proteomics / Q000379:methods*; D012878:Skin Neoplasms / Q000235:genetics / Q000378:metabolism / Q000473:pathology*
chemical_list: D015415:Biomarkers; D020543:Proteome