title: Discordances Between Pre-Natal and Post-Natal Diagnoses of Congenital Heart Diseases and Impact on Care Strategies.
abstract: Pre-natal diagnosis of congenital heart disease (CHD) allows anticipation of urgent neonatal treatment and provides adequate information to the parents on cardiac outcomes.
  
  
  
  This study sought to analyze the discordances between expert fetal cardiac diagnosis and final diagnosis of CHD and their impact on neonatal and long-term care strategies.
  
  
  
  We included 1,258 neonates with a pre-natally diagnosed CHD and 189 fetopsies following termination of pregnancy at our tertiary center over a 10-year period. Pre-natal echocardiographic and final diagnoses were compared.
  
  
  
  For live births, we identified 368 (29.3%) discordances between pre- and post-natal diagnoses. The pre-natal diagnosis was different from the post-natal diagnosis in 36 cases (2.9%) and partially different with a major impact on neonatal treatment of the CHD in 97 cases (7.7%). In 235 cases (18.7%), the diagnosis was partially different with no impact on neonatal planned treatment. The discordances had a negative impact on late care strategy in 62 cases (4.9%): more complex CHD that was unsuitable for biventricular repair, leading to unplanned compassionate care, additional surgery or increase of the complexity level of the Aristotle score. A positive impact was found in 31 cases (2.5%): less complex CHD that allowed biventricular repair, fewer surgical procedures, or decrease of the complexity of the Aristotle score. For 275 patients (21.9%), there was no impact on late care strategy. Of the 872 terminations of pregnancy and intrauterine fetal deaths, 189 fetopsies were available: 16 (8.5%) different diagnoses, 27 (14.3%) major differences, and 60 (31.7%) minor differences.
  
  
  
  Correcting fetal cardiac diagnosis after birth can lead to significant changes in neonatal (10.6%) and late (7.4%) care strategies. Tools should be developed to try to improve the accuracy of pre-natal diagnosis of CHD. Clinicians should be cautious when predicting required treatment and outcomes during pre-natal counseling.
authors: Unité Médico-Chirurgicale de Cardiologie Congénitale et Pédiatrique, Centre de Référence Malformations Cardiaques Congénitales Complexes, M3C, Hôpital Necker Enfants Malades, Assistance publique hôpitaux de Paris, Paris, France; Université Paris Descartes, Sorbonne Paris Cité, Paris, France. Electronic address: myriam.bensemlali@gmail.com.
authors: Myriam
authors: M
authors: Bensemlali
authors: Université Paris Descartes, Sorbonne Paris Cité, Paris, France; Service de Gynécologie-Obstétrique, Maternité, Hôpital Necker Enfants Malades, Assistance publique hôpitaux de Paris, Paris, France.
authors: Julien
authors: J
authors: Stirnemann
authors: Unité Médico-Chirurgicale de Cardiologie Congénitale et Pédiatrique, Centre de Référence Malformations Cardiaques Congénitales Complexes, M3C, Hôpital Necker Enfants Malades, Assistance publique hôpitaux de Paris, Paris, France.
authors: Jérôme
authors: J
authors: Le Bidois
authors: Unité Médico-Chirurgicale de Cardiologie Congénitale et Pédiatrique, Centre de Référence Malformations Cardiaques Congénitales Complexes, M3C, Hôpital Necker Enfants Malades, Assistance publique hôpitaux de Paris, Paris, France.
authors: Marilyne
authors: M
authors: Lévy
authors: Unité Médico-Chirurgicale de Cardiologie Congénitale et Pédiatrique, Centre de Référence Malformations Cardiaques Congénitales Complexes, M3C, Hôpital Necker Enfants Malades, Assistance publique hôpitaux de Paris, Paris, France.
authors: Francesca
authors: F
authors: Raimondi
authors: Unité Médico-Chirurgicale de Cardiologie Congénitale et Pédiatrique, Centre de Référence Malformations Cardiaques Congénitales Complexes, M3C, Hôpital Necker Enfants Malades, Assistance publique hôpitaux de Paris, Paris, France.
authors: Eric
authors: E
authors: Hery
authors: Unité Médico-Chirurgicale de Cardiologie Congénitale et Pédiatrique, Centre de Référence Malformations Cardiaques Congénitales Complexes, M3C, Hôpital Necker Enfants Malades, Assistance publique hôpitaux de Paris, Paris, France.
authors: Bertrand
authors: B
authors: Stos
authors: Laboratoire de Foetopathologie, Hôpital Necker Enfants Malades, Assistance publique hôpitaux de Paris, Paris, France.
authors: Bettina
authors: B
authors: Bessières
authors: Unité Médico-Chirurgicale de Cardiologie Congénitale et Pédiatrique, Centre de Référence Malformations Cardiaques Congénitales Complexes, M3C, Hôpital Necker Enfants Malades, Assistance publique hôpitaux de Paris, Paris, France; Université Paris Descartes, Sorbonne Paris Cité, Paris, France.
authors: Younes
authors: Y
authors: Boudjemline
authors: Unité Médico-Chirurgicale de Cardiologie Congénitale et Pédiatrique, Centre de Référence Malformations Cardiaques Congénitales Complexes, M3C, Hôpital Necker Enfants Malades, Assistance publique hôpitaux de Paris, Paris, France; Université Paris Descartes, Sorbonne Paris Cité, Paris, France.
authors: Damien
authors: D
authors: Bonnet
mesh_terms: D004452:Echocardiography / Q000379:methods*; D005260:Female; D005544:Forecasting; D017408:Guidelines as Topic; D006330:Heart Defects, Congenital / Q000175:diagnosis* / Q000628:therapy; D006801:Humans; D007231:Infant, Newborn; D008134:Long-Term Care / Q000592:standards*; D008297:Male; D011247:Pregnancy; D011256:Pregnancy Outcome; D011296:Prenatal Diagnosis / Q000379:methods*; D015203:Reproducibility of Results; D012189:Retrospective Studies; D012307:Risk Factors
keywords: congenital cardiac disease; diagnosis; echocardiography; imaging; pediatrics