title: Ficus religiosa L. bark extracts inhibit infection by herpes simplex virus type 2 in vitro.
abstract: Ficus religiosa extracts have been used in traditional Indian medicine to treat sexually transmitted infections such as gonorrhea and genital ulcers. The aim of this study was to investigate the antiviral activity of F. religiosa extracts against herpes simplex virus type 2 (HSV-2), the main causative agent of genital ulcers and sores. Water and chloroform bark extracts were the most active against HSV-2, and also against an acyclovir-resistant strain. We demonstrate that the water extract has a direct virus-inactivating activity. By contrast, the chloroform extract inhibits viral attachment and entry and limits the production of viral progeny.
authors: Department of Pharmaceutical Sciences and Technology, Birla Institute of Technology, Mesra, Ranchi, 835215, India.
authors: Manik
authors: M
authors: Ghosh
authors: Department of Clinical and Biological Sciences, S. Luigi Gonzaga Hospital, University of Torino, Regione Gonzole, 10, Orbassano, 10043, Turin, Italy.
authors: Andrea
authors: A
authors: Civra
authors: Department of Clinical and Biological Sciences, S. Luigi Gonzaga Hospital, University of Torino, Regione Gonzole, 10, Orbassano, 10043, Turin, Italy.
authors: Massimo
authors: M
authors: Rittà
authors: Department of Clinical and Biological Sciences, S. Luigi Gonzaga Hospital, University of Torino, Regione Gonzole, 10, Orbassano, 10043, Turin, Italy.
authors: Valeria
authors: V
authors: Cagno
authors: Department of Pharmaceutical Sciences and Technology, Birla Institute of Technology, Mesra, Ranchi, 835215, India.
authors: Siva Ganesh
authors: SG
authors: Mavuduru
authors: Department of Pharmaceutical Sciences and Technology, Birla Institute of Technology, Mesra, Ranchi, 835215, India.
authors: Preeti
authors: P
authors: Awasthi
authors: Department of Clinical and Biological Sciences, S. Luigi Gonzaga Hospital, University of Torino, Regione Gonzole, 10, Orbassano, 10043, Turin, Italy.
authors: David
authors: D
authors: Lembo
authors: Department of Clinical and Biological Sciences, S. Luigi Gonzaga Hospital, University of Torino, Regione Gonzole, 10, Orbassano, 10043, Turin, Italy. manuela.donalisio@unito.it.
authors: Manuela
authors: http://orcid.org/0000-0001-7883-1523
authors: M
authors: Donalisio
mesh_terms: D000998:Antiviral Agents / Q000302:isolation & purification / Q000494:pharmacology*; D030681:Ficus / Q000737:chemistry*; D018258:Herpesvirus 2, Human / Q000187:drug effects* / Q000502:physiology; D006801:Humans; D024301:Plant Bark / Q000737:chemistry*; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology*; D053585:Virus Attachment / Q000187:drug effects; D038301:Virus Inactivation; D053586:Virus Internalization / Q000187:drug effects
chemical_list: D000998:Antiviral Agents; D010936:Plant Extracts
keywords: Antiviral; Ficus religiosa; HSV-2; Plant extract