title: Associations of dietary and serum magnesium with serum high-sensitivity C-reactive protein in early radiographic knee osteoarthritis patients.
abstract: BACKGROUND
  This study aimed to examine the associations of dietary magnesium (Mg) intake and serum Mg concentration with the high-sensitivity C-reactive protein (hsCRP) level in early radiographic knee osteoarthritis (OA) patients.
  
  
  METHODS
  Multivariable logistic regression was used to test the associations of dietary and serum Mg with the serum hsCRP in early radiographic knee OA patients after adjustment of a number of potential confounding factors.
  
  
  RESULTS
  A total of 936 early radiographic knee OA patients were included. A significant association between dietary Mg intake and hsCRP was observed. The multivariable-adjusted odds ratio (OR) (95% CI) for elevated hsCRP (≥3.0 mg/l) in the second, third, fourth, and fifth dietary Mg intake quintile were 0.44 (95% CI: 0.24-0.82), 0.58 (95% CI: 0.31-1.10), 0.34 (95% CI: 0.15-0.77), and 0.19 (95% CI: 0.06-0.57), respectively, compared with the lowest (first) quintile, and p for trend was 0.01. A significant association between serum Mg concentration and hsCRP was observed. The multivariable-adjusted OR (95% CI) for elevated hsCRP in the second, third, fourth, and fifth serum Mg concentration quintile were 0.63 (95% CI: 0.35-1.12), 0.83 (95% CI: 0.50-1.39), 0.53 (95% CI: 0.31-0.91), and 0.46 (95% CI: 0.25-0.85), respectively, compared with the lowest quintile, and p for trend was 0.01.
  
  
  CONCLUSIONS
  The present study indicated that both dietary and serum Mg were inversely associated with serum hsCRP in early radiographic knee OA patients.
authors: a Department of Orthopaedics , Xiangya Hospital, Central South University , Changsha , China.
authors: Hui
authors: H
authors: Li
authors: a Department of Orthopaedics , Xiangya Hospital, Central South University , Changsha , China.
authors: Chao
authors: C
authors: Zeng
authors: b Health Management Center , Xiangya Hospital, Central South University , Changsha , China , and.|c Department of Epidemiology and Health Statistics, School of Public Health , Central South University , Changsha , China.
authors: Jie
authors: J
authors: Wei
authors: a Department of Orthopaedics , Xiangya Hospital, Central South University , Changsha , China.
authors: Tuo
authors: T
authors: Yang
authors: a Department of Orthopaedics , Xiangya Hospital, Central South University , Changsha , China.
authors: Shu-Guang
authors: SG
authors: Gao
authors: a Department of Orthopaedics , Xiangya Hospital, Central South University , Changsha , China.
authors: Wei
authors: W
authors: Luo
authors: a Department of Orthopaedics , Xiangya Hospital, Central South University , Changsha , China.
authors: Yu-Sheng
authors: YS
authors: Li
authors: a Department of Orthopaedics , Xiangya Hospital, Central South University , Changsha , China.
authors: Yi-Lin
authors: YL
authors: Xiong
authors: a Department of Orthopaedics , Xiangya Hospital, Central South University , Changsha , China.
authors: Wen-Feng
authors: WF
authors: Xiao
authors: a Department of Orthopaedics , Xiangya Hospital, Central South University , Changsha , China.
authors: Guang-Hua
authors: GH
authors: Lei
mesh_terms: D000328:Adult; D002097:C-Reactive Protein / Q000032:analysis*; D003430:Cross-Sectional Studies; D004032:Diet; D005260:Female; D006801:Humans; D008274:Magnesium / Q000097:blood*; D008297:Male; D008875:Middle Aged; D020370:Osteoarthritis, Knee / Q000097:blood* / Q000000981:diagnostic imaging*; D011859:Radiography
chemical_list: D002097:C-Reactive Protein; D008274:Magnesium
keywords: High-sensitivity C-reactive protein; Magnesium; Osteoarthritis