title: ADAM9 Expression Is Associate with Glioma Tumor Grade and Histological Type, and Acts as a Prognostic Factor in Lower-Grade Gliomas.
abstract: The A disintegrin and metalloproteinase 9 (ADAM9) protein has been suggested to promote carcinoma invasion and appears to be overexpressed in various human cancers. However, its role has rarely been investigated in gliomas and, thus, in the current study we have evaluated ADAM9 expression in gliomas and examined the relevance of its expression in the prognosis of glioma patients. Clinical characteristics, RNA sequence data, and the case follow-ups were reviewed for 303 patients who had histological, confirmed gliomas. The ADAM9 expression between lower-grade glioma (LGG) and glioblastoma (GBM) patients was compared and its association with progression-free survival (PFS) and overall survival (OS) was assessed to evaluate its prognostic value. Our data suggested that GBM patients had significantly higher expression of ADAM9 in comparison to LGG patients (p < 0.001, t-test). In addition, among the LGG patients, aggressive astrocytic tumors displayed significantly higher ADAM9 expression than oligodendroglial tumors (p < 0.001, t-test). Moreover, high ADAM9 expression also correlated with poor clinical outcome (p < 0.001 and p < 0.001, log-rank test, for PFS and OS, respectively) in LGG patients. Further, multivariate analysis suggested ADAM9 expression to be an independent marker of poor survival (p = 0.002 and p = 0.003, for PFS and OS, respectively). These results suggest that ADAM9 mRNA expression is associated with tumor grade and histological type in gliomas and can serve as an independent prognostic factor, specifically in LGG patients.
authors: Beijing Neurosurgical Institute, Capital Medical University, Beijing 100050, China. xingkongyaoxiang@163.com.
authors: Xing
authors: X
authors: Fan
authors: Beijing Neurosurgical Institute, Capital Medical University, Beijing 100050, China. 13031887878@163.com.|Department of Neurosurgery, Qinhuangdao First Hospital, Qinhuangdao 066000, China. 13031887878@163.com.
authors: Yongheng
authors: Y
authors: Wang
authors: Beijing Neurosurgical Institute, Capital Medical University, Beijing 100050, China. chuanbao123@139.com.
authors: Chuanbao
authors: C
authors: Zhang
authors: Department of Ophthalmology, Qinhuangdao First Hospital, Qinhuangdao 066000, China. 15603377991@163.com.
authors: Li
authors: L
authors: Liu
authors: Department of Radiotherapy, Qinhuangdao First Hospital, Qinhuangdao 066000, China. yangsen929@163.com.
authors: Sen
authors: S
authors: Yang
authors: Beijing Neurosurgical Institute, Capital Medical University, Beijing 100050, China. tiantanyinyan@126.com.|Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing100050, China. tiantanyinyan@126.com.
authors: Yinyan
authors: Y
authors: Wang
authors: Beijing Neurosurgical Institute, Capital Medical University, Beijing 100050, China. 15846591696@126.com.
authors: Xing
authors: X
authors: Liu
authors: Beijing Neurosurgical Institute, Capital Medical University, Beijing 100050, China. qianzenghui1987@163.com.
authors: Zenghui
authors: Z
authors: Qian
authors: Beijing Neurosurgical Institute, Capital Medical University, Beijing 100050, China. fangtuo1@aliyun.com.
authors: Shengyu
authors: S
authors: Fang
authors: Beijing Neurosurgical Institute, Capital Medical University, Beijing 100050, China. hqiao1215@sina.com.
authors: Hui
authors: H
authors: Qiao
authors: Beijing Neurosurgical Institute, Capital Medical University, Beijing 100050, China. taojiang1964@163.com.|Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing100050, China. taojiang1964@163.com.
authors: Tao
authors: T
authors: Jiang
mesh_terms: D051722:ADAM Proteins / Q000235:genetics*; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D018572:Disease-Free Survival; D005260:Female; D005909:Glioblastoma / Q000235:genetics / Q000401:mortality / Q000473:pathology; D005910:Glioma / Q000235:genetics* / Q000401:mortality / Q000473:pathology*; D006801:Humans; D008297:Male; D008565:Membrane Proteins / Q000235:genetics*; D008875:Middle Aged; D015999:Multivariate Analysis; D011379:Prognosis; D012333:RNA, Messenger / Q000235:genetics; D055815:Young Adult
chemical_list: D008565:Membrane Proteins; D012333:RNA, Messenger; D051722:ADAM Proteins; C098339:ADAM9 protein, human
keywords: A disintegrin and metalloproteinases 9 (ADAM9); glioma; histological type; prognosis; tumor grade