title: The Association of Genetic Predisposition to Depressive Symptoms with Non-suicidal and Suicidal Self-Injuries.
abstract: Non-suicidal and suicidal self-injury are very destructive, yet surprisingly common behaviours. Depressed mood is a major risk factor for non-suicidal self-injury (NSSI), suicidal ideation and suicide attempts. We conducted a genetic risk prediction study to examine the polygenic overlap of depressive symptoms with lifetime NSSI, suicidal ideation, and suicide attempts in a sample of 6237 Australian adult twins and their family members (3740 females, mean age = 42.4 years). Polygenic risk scores for depressive symptoms significantly predicted suicidal ideation, and some predictive ability was found for suicide attempts; the polygenic risk scores explained a significant amount of variance in suicidal ideation (lowest p = 0.008, explained variance ranging from 0.10 to 0.16 %) and, less consistently, in suicide attempts (lowest p = 0.04, explained variance ranging from 0.12 to 0.23 %). Polygenic risk scores did not significantly predict NSSI. Results highlight that individuals genetically predisposed to depression are also more likely to experience suicidal ideation/behaviour, whereas we found no evidence that this is also the case for NSSI.
authors: Department of Clinical Developmental Psychology and EMGO Institute for Health and Care Research, Vrije Universiteit Amsterdam, 1081 BT, Amsterdam, The Netherlands.
authors: Dominique F
authors: DF
authors: Maciejewski
authors: Genetic Epidemiology, Molecular Epidemiology and Neurogenetics Laboratories, QIMR Berghofer Medical Research Institute, Brisbane, QLD, 4006, Australia.
authors: Miguel E
authors: ME
authors: Renteria
authors: Department of Biological Psychology, Vrije Universiteit Amsterdam, Van der Boechorststraat 1, 1081 BT, Amsterdam, The Netherlands.
authors: Abdel
authors: A
authors: Abdellaoui
authors: Genetic Epidemiology, Molecular Epidemiology and Neurogenetics Laboratories, QIMR Berghofer Medical Research Institute, Brisbane, QLD, 4006, Australia.
authors: Sarah E
authors: SE
authors: Medland
authors: Department of Psychiatry, Washington University School of Medicine, St Louis, MO, 63110, USA.
authors: Lauren R
authors: LR
authors: Few
authors: Genetic Epidemiology, Molecular Epidemiology and Neurogenetics Laboratories, QIMR Berghofer Medical Research Institute, Brisbane, QLD, 4006, Australia.
authors: Scott D
authors: SD
authors: Gordon
authors: Department of Psychiatry, Washington University School of Medicine, St Louis, MO, 63110, USA.
authors: Pamela A F
authors: PA
authors: Madden
authors: Genetic Epidemiology, Molecular Epidemiology and Neurogenetics Laboratories, QIMR Berghofer Medical Research Institute, Brisbane, QLD, 4006, Australia.
authors: Grant
authors: G
authors: Montgomery
authors: Department of Psychological Sciences, University of Missouri, Columbia, MO, 65211, USA.
authors: Timothy J
authors: TJ
authors: Trull
authors: Department of Psychiatry, Washington University School of Medicine, St Louis, MO, 63110, USA.
authors: Andrew C
authors: AC
authors: Heath
authors: Faculty of Arts and Social Sciences, University of Sunshine Coast, Sippy Downs, QLD, 4556, Australia.
authors: Dixie J
authors: DJ
authors: Statham
authors: Genetic Epidemiology, Molecular Epidemiology and Neurogenetics Laboratories, QIMR Berghofer Medical Research Institute, Brisbane, QLD, 4006, Australia.
authors: Nicholas G
authors: NG
authors: Martin
authors: Genetic Epidemiology, Molecular Epidemiology and Neurogenetics Laboratories, QIMR Berghofer Medical Research Institute, Brisbane, QLD, 4006, Australia.|School of Psychology, University of Queensland, St. Lucia, Brisbane, QLD, 4029, Australia.
authors: Brendan P
authors: BP
authors: Zietsch
authors: Department of Biological Psychology, Vrije Universiteit Amsterdam, Van der Boechorststraat 1, 1081 BT, Amsterdam, The Netherlands. karin.verweij@vu.nl.|School of Psychology, University of Queensland, St. Lucia, Brisbane, QLD, 4029, Australia. karin.verweij@vu.nl.
authors: Karin J H
authors: KJ
authors: Verweij
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003863:Depression / Q000235:genetics*; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D008875:Middle Aged; D020412:Multifactorial Inheritance / Q000235:genetics; D012307:Risk Factors; D016728:Self-Injurious Behavior / Q000235:genetics*; D059020:Suicidal Ideation; D055815:Young Adult
keywords: Depression; Genetics; Polygenic risk; Self-injury; Suicidal ideation; Suicide attempts