title: Impaired Myocardial Bioenergetics in HFpEF and the Role of Antioxidants.
abstract: Heart failure with preserved ejection fraction (HFpEF) is a significant cardiovascular condition for more than 50% of patients with heart failure. Currently, there is no effective treatment to decrease morbidity and mortality rates associated with HFpEF because of its pathophysiological heterogeneity. Recent evidence shows that deficiency in myocardial bioenergetics is one of the key pathophysiological factors contributing to diastolic dysfunction in HFpEF. Another known mechanism for HFpEF is an overproduction of free radicals, specifically reactive oxygen species. To reduce free radical formation, antioxidants are often used. This article is a summative review of the recent relevant literature that addresses cardiac bioenergetics, deficiency in myocardial bioenergetics, and increased reactive oxygen species associated with HFpEF and the promising potential use of antioxidants in managing this condition.
authors: University of Kansas, School of Nursing, Kansas, USA.
authors: John B
authors: JB
authors: Hiebert
authors: University of Kansas, School of Nursing, Kansas, USA.
authors: Qiuhua
authors: Q
authors: Shen
authors: University of Kansas, School of Nursing, Kansas, USA.
authors: Amanda
authors: A
authors: Thimmesch
authors: University of Kansas, School of Nursing, Kansas, USA.
authors: Janet
authors: J
authors: Pierce
keywords: Adenosine triphosphate; Antioxidants; Bioenergetics; Diastolic heart failure; Free radicals; Heart failure with preserved ejection fraction