title: Immunohistochemical biomarkers in ameloblastomas.
abstract: Ameloblastoma is an aggressive odontogenic tumour, which is locally invasive and highly recurrent. Studies show that ameloblastoma is a benign odontogenic neoplasia, being relatively rare and occasionally presenting behaviour of malignant lesions. In addition to these particularities, the histological diagnosis of ameloblastoma can be challenging when the tumour shows high rates of mitosis, absence of nuclear pleomorphism, basilar hyperplasia and neural invasion. In order to help in the diagnosis, prognosis and treatment of this neoplasia, some immunohistochemical markers were shown to be associated with tumoural epithelium. The identification of these markers as well as of their association with clinical signs can be useful to elaborate more efficient treatment strategies and to control this pathology, including improvement of the quality of life of patients affected by this neoplasia. This article aims to review some markers associated with specific molecular pathways, bone remodelling, cell proliferation, apoptosis, cell signalling and tumour suppression.
authors: a Unit of Oral and Maxillofacial Surgery , Santa Casa de São Paulo School of Medical Sciences , São Paulo , Brazil.|b Department of Stomatology, Division of General Pathology , School of Dentistry, University of São Paulo , São Paulo , Brazil.
authors: Alan Motta
authors: AM
authors: do Canto
authors: a Unit of Oral and Maxillofacial Surgery , Santa Casa de São Paulo School of Medical Sciences , São Paulo , Brazil.
authors: Juliana Rodrigues
authors: JR
authors: Rozatto
authors: c Department of Stomatology , Federal University of Paraná , Curitiba , Brazil.|d Department of Oral and Maxillofacial Surgery , Erasto Gaertner Hospital , Curitiba , Brazil.
authors: Juliana Lucena
authors: JL
authors: Schussel
authors: a Unit of Oral and Maxillofacial Surgery , Santa Casa de São Paulo School of Medical Sciences , São Paulo , Brazil.
authors: Ronaldo Rodrigues
authors: RR
authors: de Freitas
authors: e Department of Oral Medicine and Pathology , Institute of Odontology, The Sahlgrenska Academy, University of Gothenburg , Gothenburg , Sweden.
authors: Bengt
authors: B
authors: Hasséus
authors: b Department of Stomatology, Division of General Pathology , School of Dentistry, University of São Paulo , São Paulo , Brazil.
authors: Paulo Henrique
authors: PH
authors: Braz-Silva
mesh_terms: D000328:Adult; D000564:Ameloblastoma / Q000378:metabolism* / Q000473:pathology; D017209:Apoptosis; D014408:Biomarkers, Tumor / Q000378:metabolism*; D049109:Cell Proliferation; D015870:Gene Expression; D006801:Humans; D007573:Jaw Neoplasms / Q000378:metabolism* / Q000473:pathology; D051736:Proto-Oncogene Proteins c-mdm2 / Q000378:metabolism*
chemical_list: D014408:Biomarkers, Tumor; D051736:Proto-Oncogene Proteins c-mdm2
keywords: Ameloblastoma; immunohistochemistry; jaw; odontogenic tumours