title: Chorioamnionitis and subsequent bronchopulmonary dysplasia in very-low-birth weight infants: a 25-year cohort.
abstract: To determine whether chorioamnionitis (CA) or sepsis were associated with bronchopulmonary dysplasia (BPD) in a 25-year cohort of very-low-birth weight (VLBW) infants.
  
  
  
  VLBW infants ⩽32 weeks gestation admitted to the neonatal intensive care unit between 1989 and 2014 were reviewed. BPD was defined using the National Institutes of Health consensus definition. CA was defined clinically. Logistic regression models were used for BPD prediction.
  
  
  
  One thousand six hundred and eighty-seven infants were included; 44% (n=740) had moderate or severe BPD. In multivariable analysis, lower gestational age (odds ratio (OR) 1.12 per week (95% confidence interval (CI) 1.11, 1.14)), sepsis (OR 2.03 (95% CI 1.49, 2.77)) and birth year ⩾1995 (OR 1.49 (95% CI 1.09, 2.04)) were significant predictors of BPD. CA was not associated with BPD (OR 1.18 (95% CI 0.66, 2.11)).
  
  
  
  Sepsis, but not CA, is associated with the development of moderate or severe BPD in VLBW infants after controlling for gestational age.
authors: Department of Pediatrics, Texas A&M Health Science Center, Temple, TX, USA.
authors: A R
authors: AR
authors: Ballard
authors: Department of Pediatrics, Texas A&M Health Science Center, Temple, TX, USA.
authors: L H
authors: LH
authors: Mallett
authors: Department of Biostatistics, Texas A&M Health Science Center, Temple, TX, USA.
authors: J E
authors: JE
authors: Pruszynski
authors: Department of Pediatrics, Texas A&M Health Science Center, Temple, TX, USA.
authors: J B
authors: JB
authors: Cantey
mesh_terms: D001997:Bronchopulmonary Dysplasia / Q000453:epidemiology*; D002821:Chorioamnionitis / Q000453:epidemiology*; D015331:Cohort Studies; D005260:Female; D005865:Gestational Age; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D019102:Infant, Very Low Birth Weight; D007363:Intensive Care Units, Neonatal / Q000706:statistics & numerical data; D016015:Logistic Models; D008297:Male; D016017:Odds Ratio; D011247:Pregnancy; D012307:Risk Factors; D018805:Sepsis / Q000097:blood / Q000453:epidemiology*; D012720:Severity of Illness Index