title: EEG Markers of Dementia with Lewy Bodies: A Multicenter Cohort Study.
abstract: Quantitative EEG (QEEG) has demonstrated good discriminative capacity for dementia with Lewy bodies (DLB) diagnosis as compared to Alzheimer's disease (AD) with a predictive value of 100% in a single cohort study. EEG in DLB was characterized by a dominant frequency (DF) in pre-alpha (5.5-7.5 Hz), theta, or delta bands and DF variability (DFV) >1.2 Hz, frequency prevalence (FP) pre-alpha in >40% and FP alpha in <32% of the epochs. To validate the aforementioned QEEG findings in independent cohorts of clinically diagnosed DLB versus AD patients, we analyzed EEG traces of 79 DLB and 133 AD patients (MMSE >20) collected from four European Centers. EEG traces from 19 scalp derivations were acquired as at least 10 min continuous signals and epoched in off-setting as series of 2-second-long epochs, subsequently processed by Fast Fourier Transform (frequency resolution 0.5 Hz). DLB patients showed EEG specific abnormalities in posterior derivations characterized by DF <8 Hz FP pre-alpha >50%, FP alpha <25%. DFV was >0.5 Hz. AD patients displayed stable alpha DF, DFV <0.5 Hz, FP pre-alpha <30%, and FP alpha >55%. DLB and AD differed for DF (p < 10-6), DFV (p < 0.05), FP pre-alpha (p < 10-12) and FP alpha (p < 10-12). Discriminant analysis detected specific cut-offs for every EEG mathematical descriptor; DF = 8, DFV = 2.2 Hz, FP pre-alpha=33%, FP alpha = 41% for posterior derivations. If at least one of the cut-off values was met, the percentage of DLB and AD patients correctly classified was 90% and 64%, respectively. The findings in this multicenter study support the validity of QEEG analysis as a tool for diagnosis in DLB patients.
authors: Department of Neuroscience, Imaging and Clinical Science, and Aging Research Centre, G. d'Annunzio University of Chieti-Pescara, Chieti, Italy.
authors: Laura
authors: L
authors: Bonanni
authors: Department of Neuroscience, Imaging and Clinical Science, and Aging Research Centre, G. d'Annunzio University of Chieti-Pescara, Chieti, Italy.
authors: Raffaella
authors: R
authors: Franciotti
authors: Clinical Neurology, Department of Neuroscience (DINOGMI), University of Genoa and IRCCS AOU San Martino-IST, Genoa, Italy.
authors: Flavio
authors: F
authors: Nobili
authors: Department of Neurology, University Medical Centre, Ljubljana, Slovenia.
authors: Milica G
authors: MG
authors: Kramberger
authors: Campus for Ageing and Vitality, Newcastle University, Newcastle upon Tyne, UK.
authors: John-Paul
authors: JP
authors: Taylor
authors: Department of Neurobiology, Care Sciences and Society, Center for Alzheimer Research, Division of Clinical Geriatrics, Karolinska Institutet, and Memory Clinic Department of Geriatric Medicine, Karolinska University Hospital, Stockholm, Sweden.
authors: Sara
authors: S
authors: Garcia-Ptacek
authors: BIND - Behavioral Imaging and Neural Dynamics Center, G. d'Annunzio University of Chieti-Pescara, Chieti, Italy.
authors: N Walter
authors: NW
authors: Falasca
authors: Clinical Neurology, Department of Neuroscience (DINOGMI), University of Genoa and IRCCS AOU San Martino-IST, Genoa, Italy.
authors: Francesco
authors: F
authors: Famá
authors: Campus for Ageing and Vitality, Newcastle University, Newcastle upon Tyne, UK.
authors: Ruth
authors: R
authors: Cromarty
authors: Department of Neuroscience, Imaging and Clinical Science, and Aging Research Centre, G. d'Annunzio University of Chieti-Pescara, Chieti, Italy.
authors: Marco
authors: M
authors: Onofrj
authors: King's College of London, London, UK.
authors: Dag
authors: D
authors: Aarsland
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000175:diagnosis / Q000453:epidemiology / Q000503:physiopathology; D058256:Brain Waves / Q000502:physiology; D015331:Cohort Studies; D003937:Diagnosis, Differential; D004569:Electroencephalography / Q000639:trends*; D005060:Europe / Q000453:epidemiology; D005260:Female; D006801:Humans; D038622:Internationality; D020961:Lewy Body Disease / Q000175:diagnosis* / Q000453:epidemiology / Q000503:physiopathology*; D008297:Male
keywords: Dementia with Lewy bodies; quantitative EEG