title: Synthesis, Characterization, Antimicrobial and Antioxidant Activities of The Homocyclotrimer Of 4-Oxo-4h-Thieno[3,4-C]Chromene-3-Diazonium Sulfate.
abstract: The in situ formed 4-oxo-4H-thieno[3,4-c]chromene-3-diazonium sulfate (5) in the coupling reactions involving the parent 2-aminothiophene (4) and various phenolic and arylamines' couplers, readily undergoes homocyclotrimerization at low temperature to afford in fairly good yield the first ever reported eighteen member ring heteroaromatic holigomer 6. Compound 6 was fully characterized by its elemental analysis, IR, UV-Vis, (1)H-NMR, (13)C-NMR and HRMS spectral data. The HMBC and HSQC techniques were used to ascertain the structural assignments. A comparative study on the antimicrobial and antioxidant activities of compounds 3, 4 and 6 was carried out to assess the SAR due to the transformations (from 3 to 6 via 4) on the tested compounds. It was found that compounds 6 and 4 were respectively the most active compounds against bacteria (MIC = 32-64 μg/ml) and yeasts (MIC = 16-64 μg/ml). Compound 6 also showed high radical-scavenging activities and ferric reducing power when compared with vitamin C and BHT used as reference antioxidants.
authors: Laboratory of Applied Synthetic Organic Chemistry, Department of Chemistry, Faculty of Science, University of Dschang, P.O. Box 67 Dschang, Republic of Cameroon.
authors: Emmanuel
authors: E
authors: Sopbue Fondjo
authors: Laboratory of Applied Synthetic Organic Chemistry, Department of Chemistry, Faculty of Science, University of Dschang, P.O. Box 67 Dschang, Republic of Cameroon.
authors: Djeukoua Dimo Kamal
authors: DD
authors: Sorel
authors: Laboratory of Microbiology and antimicrobial Substances, Department of Biochemistry, Faculty of Science, University of Dschang, PO Box 067 Dschang, Republic of Cameroon.
authors: Tamokou
authors: T
authors: Jean-de-Dieu
authors: Laboratory of Applied Synthetic Organic Chemistry, Department of Chemistry, Faculty of Science, University of Dschang, P.O. Box 67 Dschang, Republic of Cameroon.
authors: Tsemeugne
authors: T
authors: Joseph
authors: Laboratory of Applied Synthetic Organic Chemistry, Department of Chemistry, Faculty of Science, University of Dschang, P.O. Box 67 Dschang, Republic of Cameroon.
authors: Kouamo
authors: K
authors: Sylvian
authors: Laboratory of Applied Synthetic Organic Chemistry, Department of Chemistry, Faculty of Science, University of Dschang, P.O. Box 67 Dschang, Republic of Cameroon.
authors: Ngouanet
authors: N
authors: Doriane
authors: Laboratory of Applied Synthetic Organic Chemistry, Department of Chemistry, Faculty of Science, University of Dschang, P.O. Box 67 Dschang, Republic of Cameroon.
authors: Chouna Jean
authors: CJ
authors: Rodolphe
authors: Laboratory of Applied Synthetic Organic Chemistry, Department of Chemistry, Faculty of Science, University of Dschang, P.O. Box 67 Dschang, Republic of Cameroon.
authors: Nkeng-Efouet-Alango
authors: NE
authors: Pepin
authors: Laboratory of Microbiology and antimicrobial Substances, Department of Biochemistry, Faculty of Science, University of Dschang, PO Box 067 Dschang, Republic of Cameroon.
authors: Kuiate
authors: K
authors: Jules-Roger
authors: Technical University of Munich, Department of Chemistry Lichtenbergstrasse 4, D-85747 Garching, Germany.
authors: Ngongang Ndjintchui
authors: NN
authors: Arnaud
authors: Department of Organic Chemistry, University of Yaounde I, P.O. Box 812 Yaounde, Republic of Cameroon.
authors: Sondengam Beibam
authors: SB
authors: Lucas
keywords: 2-aminothiophene; Antimicrobial; Antioxidant; Azo compounds; Coumarin; Holigomer; Homocyclotrimerization; SAR