title: Near-Infrared-Triggered Azobenzene-Liposome/Upconversion Nanoparticle Hybrid Vesicles for Remotely Controlled Drug Delivery to Overcome Cancer Multidrug Resistance.
abstract: Overcoming multidrug resistance is achieved by developing a novel drugdelivery-system paradigm based on azobenzene liposome and phosphatidylcholine-modified upconversion nanoparticle (UCNP) hybrid vesicles for controlled drug release using a nearinfrared (NIR) laser. Upon 980 nm light irradiation, the reversible photoisomerization of the azobenzene derivatives by simultaneous UV and visible light emitted from the UCNPs makes it possible to realize NIR-triggered release of the chemotherapeutic drug doxorubicin.
authors: Department of Chemistry, State Key Laboratory of Molecular Engineering of Polymers, Collaborative Innovation Center of Chemistry for Energy Materials, Fudan University, Shanghai, 200433, P. R. China.
authors: Chi
authors: C
authors: Yao
authors: Department of Chemistry, State Key Laboratory of Molecular Engineering of Polymers, Collaborative Innovation Center of Chemistry for Energy Materials, Fudan University, Shanghai, 200433, P. R. China.
authors: Peiyuan
authors: P
authors: Wang
authors: Department of Chemistry, State Key Laboratory of Molecular Engineering of Polymers, Collaborative Innovation Center of Chemistry for Energy Materials, Fudan University, Shanghai, 200433, P. R. China.
authors: Xiaomin
authors: X
authors: Li
authors: School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, 210093, P. R. China.
authors: Xiaoyu
authors: X
authors: Hu
authors: Department of Chemistry, State Key Laboratory of Molecular Engineering of Polymers, Collaborative Innovation Center of Chemistry for Energy Materials, Fudan University, Shanghai, 200433, P. R. China.
authors: Junli
authors: J
authors: Hou
authors: School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, 210093, P. R. China.
authors: Leyong
authors: L
authors: Wang
authors: Department of Chemistry, State Key Laboratory of Molecular Engineering of Polymers, Collaborative Innovation Center of Chemistry for Energy Materials, Fudan University, Shanghai, 200433, P. R. China.
authors: Fan
authors: F
authors: Zhang
mesh_terms: D001391:Azo Compounds / Q000737:chemistry* / Q000528:radiation effects; D004317:Doxorubicin / Q000008:administration & dosage; D016503:Drug Delivery Systems / Q000379:methods*; D065546:Drug Liberation / Q000187:drug effects*; D018432:Drug Resistance, Multiple / Q000187:drug effects*; D006801:Humans; D007259:Infrared Rays; D007834:Lasers; D008081:Liposomes; D061986:MCF-7 Cells; D053758:Nanoparticles / Q000737:chemistry* / Q000528:radiation effects; D009369:Neoplasms / Q000188:drug therapy*; D010713:Phosphatidylcholines / Q000737:chemistry
chemical_list: D001391:Azo Compounds; D008081:Liposomes; D010713:Phosphatidylcholines; D004317:Doxorubicin; C009850:azobenzene
keywords: azobenzene-liposomes; drug delivery; multidrug-resistant cancers; upconversion nanoparticles