title: Diagnostic Value of Conventional Ultrasonography Combined with Contrast-Enhanced Ultrasonography in Thyroid Imaging Reporting and Data System (TI-RADS) 3 and 4 Thyroid Micronodules.
abstract: BACKGROUND The present study was conducted to investigate the diagnostic performance of conventional ultrasonography (US) combined with contrast-enhanced ultrasonography (CEUS) in thyroid micronodules with thyroid imaging reporting and data system (TI-RADS) category 3 and 4. MATERIAL AND METHODS The features of conventional US and CEUS ion 102 case of thyroid micronodule samples, which were diagnosed based on pathological and clinical examination, were retrospectively analyzed. Logistic regression analysis was used to analyze the diagnostic accuracy in malignant thyroid micronodules. Receiver operator characteristic (ROC) curve was used to assess the performance of those 2 technologies. RESULTS A significant difference in age was found between the benign and malignant groups. The benign and malignant groups showed significant differences in shape, margin, aspect ratio (A/T) ≥1, microcalcification, suspicious lymph gland, enhancement time, enhancement pattern, enhancement intensity, nodule sizes, enhancement margins, and rim-like enhancement. Logistic regression analysis of conventional US showed that A/T ≥1, irregular shape, microcalcification, and suspicious lymph glands are risk factors for thyroid micronodules, while logistic regression analysis of CEUS showed that slow enhancement time and absence of rim-like enhancement are risk factors for thyroid micronodules. Logistic regression analysis of conventional US combined with CEUS demonstrated that A/T ≥1, microcalcification, suspicious lymph gland, slow enhancement time, and absence with rim-like enhancement are risk factors. The ROC curve for conventional US, CEUS, and conventional US combined with CEUS were 90.0%, 90.7%, 99.0%, respectively. CONCLUSIONS Our results show that conventional US combined with CEUS had superior diagnostic performance for TI-RADS 3 and 4 thyroid micronodules compared with conventional US and CEUS alone.
authors: Department of Ultrasound Diagnosis, China Meitan General Hospital, Beijing, China (mainland).
authors: Yingxian
authors: Y
authors: Liu
authors: Department of Ultrasound Diagnosis, Sichuan Provincial People's Hospital, Chengdu, Sichuan, China (mainland).
authors: Hao
authors: H
authors: Wu
authors: Department of Ultrasound Diagnosis, Sichuan Provincial People's Hospital, Chengdu, Sichuan, China (mainland).
authors: Qing
authors: Q
authors: Zhou
authors: Department of Ultrasound Diagnosis, The Sixth People's Hospital of Chengdu, Chengdu, Sichuan, China (mainland).
authors: Jiamei
authors: J
authors: Gou
authors: Department of Ultrasound Diagnosis, China Meitan General Hospital, Beijing, China (mainland).
authors: Jinmei
authors: J
authors: Xu
authors: Department of Ultrasound Diagnosis, China Meitan General Hospital, Beijing, China (mainland).
authors: Yan
authors: Y
authors: Liu
authors: Department of Ultrasound Diagnosis, Sichuan Provincial People's Hospital, Chengdu, Sichuan, China (mainland).
authors: Qin
authors: Q
authors: Chen
mesh_terms: D000328:Adult; D000368:Aged; D003287:Contrast Media; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008198:Lymph Nodes / Q000000981:diagnostic imaging / Q000473:pathology; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D016606:Thyroid Nodule / Q000000981:diagnostic imaging* / Q000473:pathology; D014463:Ultrasonography / Q000379:methods
chemical_list: D003287:Contrast Media