title: Randomized double-blind placebo controlled study of preinduction cervical priming with 25 µg of misoprostol in the outpatient setting to prevent formal induction of labour.
abstract: OBJECTIVE
  To compare the efficacy of preinduction outpatient use of a single dose of 25 μg vaginal misoprostol between 381/2and 40 weeks with that of placebo, to decrease the interval from intervention to delivery after stretch and sweep in low-risk gravid women with Bishop's score <4.
  
  
  METHODS
  Sixty three women received 25 μg vaginal misoprostol and 63 women received placebo after stretch and sweep.
  
  
  RESULTS
  The duration from intervention to delivery was 3.35 (1.12-9.46) days in the misoprostol group and 5.42 (2.39-10.11) days in the placebo group which was statistically significant (p = 0.029). Spontaneous labor was seen in 39 women (61.9 %) in the misoprostol group and 35 women (55.6 %) in the placebo group (p = 0.531). Eight women in the misoprostol group and 18 in the placebo group had Lower Segment Caesarean Section (LSCS) and this difference was also statistically significant (p = 0.027). There were no major maternal and neonatal complications in both groups.
  
  
  CONCLUSIONS
  Preinduction use of 25 μg vaginal misoprostol after stretch and sweep in the outpatient setting decreased the intervention to delivery interval when compared to placebo.
authors: Department of Obstetrics and Gynaecology Unit V, Christian Medical College, Ida Scudder Road, Vellore, 632 004, India.
authors: Jameela
authors: J
authors: PonMalar
authors: Department of Obstetrics and Gynaecology Unit V, Christian Medical College, Ida Scudder Road, Vellore, 632 004, India.
authors: Santosh Joseph
authors: SJ
authors: Benjamin
authors: Department of Obstetrics and Gynaecology Unit V, Christian Medical College, Ida Scudder Road, Vellore, 632 004, India.
authors: Anuja
authors: A
authors: Abraham
authors: Department of Obstetrics and Gynaecology Unit V, Christian Medical College, Ida Scudder Road, Vellore, 632 004, India.
authors: Swati
authors: S
authors: Rathore
authors: Department of Biostatistics, Christian Medical College, Ida Scudder Road, Vellore, 632 004, India.
authors: Visalakshi
authors: V
authors: Jeyaseelan
authors: Department of Obstetrics and Gynaecology Unit V, Christian Medical College, Ida Scudder Road, Vellore, 632 004, India. coronistrial@yahoo.co.in.
authors: Jiji Elizabeth
authors: JE
authors: Mathews
mesh_terms: D000282:Administration, Intravaginal; D000328:Adult; D000553:Ambulatory Care; D020070:Cervical Ripening / Q000187:drug effects*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007751:Labor, Induced / Q000379:methods; D016595:Misoprostol / Q000008:administration & dosage*; D010120:Oxytocics / Q000008:administration & dosage*; D011247:Pregnancy; D013997:Time Factors; D055815:Young Adult
chemical_list: D010120:Oxytocics; D016595:Misoprostol
keywords: Cervical priming; Intervention to delivery interval; Misoprostol; Outpatient; Postdated pregnancy; Preinduction