title: Next-generation genotype imputation service and methods.
abstract: Genotype imputation is a key component of genetic association studies, where it increases power, facilitates meta-analysis, and aids interpretation of signals. Genotype imputation is computationally demanding and, with current tools, typically requires access to a high-performance computing cluster and to a reference panel of sequenced genomes. Here we describe improvements to imputation machinery that reduce computational requirements by more than an order of magnitude with no loss of accuracy in comparison to standard imputation tools. We also describe a new web-based service for imputation that facilitates access to new reference panels and greatly improves user experience and productivity.
authors: Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, USA.
authors: Sayantan
authors: S
authors: Das
authors: Division of Genetic Epidemiology, Department of Medical Genetics, Molecular and Clinical Pharmacology, Medical University of Innsbruck, Innsbruck, Austria.
authors: Lukas
authors: L
authors: Forer
authors: Division of Genetic Epidemiology, Department of Medical Genetics, Molecular and Clinical Pharmacology, Medical University of Innsbruck, Innsbruck, Austria.
authors: Sebastian
authors: S
authors: Schönherr
authors: Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, USA.|Istituto di Ricerca Genetica e Biomedica, CNR, Monserrato, Cagliari, Italy.|Dipartimento di Scienze Biomediche, Università degli Studi di Sassari, Sassari, Italy.
authors: Carlo
authors: C
authors: Sidore
authors: Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, USA.
authors: Adam E
authors: AE
authors: Locke
authors: Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, USA.
authors: Alan
authors: A
authors: Kwong
authors: Institute for Behavioral Genetics, University of Colorado, Boulder, Colorado, USA.
authors: Scott I
authors: SI
authors: Vrieze
authors: Clinical Trials Branch, Division of Epidemiology and Clinical Applications, National Eye Institute, US National Institutes of Health, Bethesda, Maryland, USA.
authors: Emily Y
authors: EY
authors: Chew
authors: HudsonAlpha Institute for Biotechnology, Huntsville, Alabama, USA.
authors: Shawn
authors: S
authors: Levy
authors: Department of Psychology, University of Minnesota, Minneapolis, Minnesota, USA.
authors: Matt
authors: M
authors: McGue
authors: Laboratory of Genetics, National Institute on Aging, US National Institutes of Health, Baltimore, Maryland, USA.
authors: David
authors: D
authors: Schlessinger
authors: Department of Genetics, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
authors: Dwight
authors: D
authors: Stambolian
authors: Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.|Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA.
authors: Po-Ru
authors: PR
authors: Loh
authors: Department of Psychology, University of Minnesota, Minneapolis, Minnesota, USA.
authors: William G
authors: WG
authors: Iacono
authors: Neurobiology-Neurodegeneration and Repair Laboratory, National Eye Institute, US National Institutes of Health, Bethesda, Maryland, USA.
authors: Anand
authors: A
authors: Swaroop
authors: Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, USA.
authors: Laura J
authors: LJ
authors: Scott
authors: Istituto di Ricerca Genetica e Biomedica, CNR, Monserrato, Cagliari, Italy.|Dipartimento di Scienze Biomediche, Università degli Studi di Sassari, Sassari, Italy.
authors: Francesco
authors: F
authors: Cucca
authors: Division of Genetic Epidemiology, Department of Medical Genetics, Molecular and Clinical Pharmacology, Medical University of Innsbruck, Innsbruck, Austria.
authors: Florian
authors: F
authors: Kronenberg
authors: Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, USA.
authors: Michael
authors: M
authors: Boehnke
authors: Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, USA.
authors: Gonçalo R
authors: GR
authors: Abecasis
authors: Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, USA.|Division of Genetic Epidemiology, Department of Medical Genetics, Molecular and Clinical Pharmacology, Medical University of Innsbruck, Innsbruck, Austria.|Center for Biomedicine, European Academy of Bolzano/Bozen (EURAC), affiliated with the University of Lübeck, Bolzano, Italy.
authors: Christian
authors: C
authors: Fuchsberger
mesh_terms: D000465:Algorithms; D003198:Computer Simulation; D055106:Genome-Wide Association Study; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D020407:Internet