title: Pentraxin 3, ischemia-modified albumin, and myeloperoxidase in predicting a cardiac damage in acute carbon monoxide poisoning.
abstract: BACKGROUND
  Carbon monoxide (CO) poisoning is associated with cardiac injuries or manifestations, frequently attributing to direct hypoxic damage at cellular level. For this, the aims were to evaluate the role of serum pentraxin 3 (PTX 3), ischemia-modified albumin (IMA), and myeloperoxidase (MPO) as an early biomarker for cardiac damage when compared to cardiac troponin I (cTnI) and creatine kinase-MB fraction (CK-MB) in adult patients with acute CO poisoning.
  
  
  METHODS
  Forty patients with acute CO poisoning admitted to the emergency department. The patients were divided into 2 main groups as follows: cardiac injury (group I, n=19) and nonsuspected cardiac injury (group II, n=21). Pentraxin 3, IMA, MPO, cTnI, CK-MB, and the other assays in the circulation were measured on admission.
  
  
  RESULTS
  Upon measuring the serum PTX 3, IMA, MPO, cTnI, and CK-MB levels as well as large electrocardiography and echocardiography abnormalities of patients with cardiac injury on admission, no statistical difference for PTX 3, IMA, and MPO was found between the groups (P>.05). However, cTnI, CK-MB, and leukocyte count (white blood cell) were higher determined in patients of group I compared to group II (P<.05). Receiver operating characteristic curve was also performed to evaluate the diagnostic performance of these tests in patients with cardiac injury.
  
  
  CONCLUSIONS
  Our results suggest that PTX, IMA, and MPO assays are not superior to cTnI and CK-MB in predicting a cardiac damage in patients with acute CO intoxication.
authors: Department of Emergency Medicine, Faculty of Medicine, Ondokuz Mayis University, 55139 Samsun, Turkey. Electronic address: ahmetbaydn@yahoo.com.
authors: Ahmet
authors: A
authors: Baydin
authors: Department of Medical Biochemistry, Faculty of Medicine, Ondokuz Mayis University, 55139 Samsun, Turkey.
authors: Ramazan
authors: R
authors: Amanvermez
authors: Department of Emergency Medicine, Faculty of Medicine, Ondokuz Mayis University, 55139 Samsun, Turkey.
authors: Hüseyin E
authors: HE
authors: Çelebi
authors: Department of Medical Biochemistry, Faculty of Medicine, Ondokuz Mayis University, 55139 Samsun, Turkey.
authors: Özgür K
authors: ÖK
authors: Tunçel
authors: Department of Cardiology, Faculty of Medicine, Ondokuz Mayis University, 55139 Samsun, Turkey.
authors: Sabri
authors: S
authors: Demircan
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000032:analysis*; D002249:Carbon Monoxide Poisoning / Q000097:blood / Q000150:complications*; D052279:Creatine Kinase, MB Form / Q000097:blood; D005260:Female; D006321:Heart / Q000187:drug effects; D006335:Heart Injuries / Q000097:blood / Q000139:chemically induced* / Q000175:diagnosis; D006801:Humans; D008297:Male; D008875:Middle Aged; D009195:Peroxidase / Q000097:blood*; D011237:Predictive Value of Tests; D000683:Serum Amyloid P-Component / Q000032:analysis*; D019210:Troponin I / Q000097:blood; D000099153:Pentraxins
chemical_list: D015415:Biomarkers; D002097:C-Reactive Protein; D052279:Creatine Kinase, MB Form; D009195:Peroxidase; D000683:Serum Amyloid P-Component; D019210:Troponin I; D000099153:Pentraxins