title: Outcomes Associated With Isolated Agenesis of the Corpus Callosum: A Meta-analysis.
abstract: BACKGROUND
  Antenatal counseling in cases of agenesis of the corpus callosum (ACC) is challenging.
  
  
  OBJECTIVE
  To ascertain the outcome in fetuses with isolated complete ACC and partial ACC.
  
  
  METHODS
  Medline, Embase, CINAHL, and Cochrane databases.
  
  
  METHODS
  Studies reporting a prenatal diagnosis of ACC. The outcomes observed were: chromosomal abnormalities at standard karyotype and chromosomal microarray (CMA) analysis, additional anomalies detected only at prenatal MRI and at postnatal imaging or clinical evaluation, concordance between prenatal and postnatal diagnosis and neurodevelopmental outcome.
  
  
  METHODS
  Meta-analyses of proportions were used to combine data.
  
  
  RESULTS
  Twenty-seven studies were included. In cACC, chromosomal anomalies occurred in 4.81% (95% confidence interval [CI], 2.2-8.4) of the cases. Gross and fine motor control were abnormal in 4.40% (95% CI, 0.6-11.3) and 10.98% (95% CI, 4.1-20.6) of the cases, respectively, whereas 6.80% (95% CI, 1.7-14.9) presented with epilepsy. Abnormal cognitive status occurred in 15.16% (95% CI, 6.9-25.9) of cases. In partial ACC, the rate of chromosomal anomalies was 7.45% (95% CI, 2.0-15.9). Fine motor control was affected in 11.74% (95% CI, 0.9-32.1) of the cases, and 16.11% (95% CI, 2.5-38.2) presented with epilepsy. Cognitive status was affected in 17.25% (95% CI, 3.0-39.7) of cases.
  
  
  CONCLUSIONS
  Different neurodevelopmental tools and time of follow-up of the included studies.
  
  
  CONCLUSIONS
  Children wih a prenatal diagnosis of isolated ACC show several degrees of impairment in motor control, coordination, language, and cognitive status. However, in view of the large heterogeneity in outcomes measures, time at follow-up, and neurodevelopmental tools used, large prospective studies are needed to ascertain the actual occurrence of neuropsychological morbidity of children with isolated ACC.
authors: Department of Clinical Medicine, Faculty of Health Sciences, UiT - The Artic University of Norway, Tromsø, Norway; francesco.dantonio@uit.no.
authors: Francesco
authors: F
authors: D'Antonio
authors: Department of Obstetrics and Gynecology, Fondazione Poliambulanza, Brescia, Italy;
authors: Giorgio
authors: G
authors: Pagani
authors: Department of Maternal-Fetal Medicine, Catholic University of the Sacred Heart, Rome, Italy;
authors: Alessandra
authors: A
authors: Familiari
authors: Fetal Medicine Unit, Division of Developmental Sciences, St. George's University of London, London, United Kingdom;
authors: Asma
authors: A
authors: Khalil
authors: Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel; Fetal Neurology Clinic and Paediatric Neurology Unit, Wolfson Medical Centre, Holon, Israel;
authors: Tally-Lerman
authors: TL
authors: Sagies
authors: Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel; GYN Ultrasound Division, Tel Aviv Medical Center, Tel Aviv, Israel;
authors: Gustavo
authors: G
authors: Malinger
authors: Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel; Fetal Neurology Clinic and Institute of Medical Genetics, Wolfson Medical Center, Holon, Israel;
authors: Zvi
authors: Z
authors: Leibovitz
authors: Service de Radiologie, Hôpital d'Enfants Armand-Trousseau, Paris, France;
authors: Catherine
authors: C
authors: Garel
authors: Service de Neuropédiatrie, Hôpital Trousseau, Hôpitaux Universitaires de l'Est Parisien, Université Pierre et Marie Curie, Paris, France;
authors: Marie Laure
authors: ML
authors: Moutard
authors: Department of Obstetrics and Gynaecology, Sant'Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy;
authors: Gianluigi
authors: G
authors: Pilu
authors: Fetal Medicine Unit, Division of Developmental Sciences, St. George's University of London, London, United Kingdom;
authors: Amar
authors: A
authors: Bhide
authors: Department of Clinical Medicine, Faculty of Health Sciences, UiT - The Artic University of Norway, Tromsø, Norway;
authors: Ganesh
authors: G
authors: Acharya
authors: Department of Obstetrics and Gynecology, University of Chieti-Pescara, Chieti, Italy;
authors: Martina
authors: M
authors: Leombroni
authors: Department of Medicine and Aging Sciences, University of Chieti-Pescara, Chieti, Italy; EMISAC, Ce.S.I. Biotech, Chieti, Italy; and.
authors: Lamberto
authors: L
authors: Manzoli
authors: Fetal Medicine Unit, Division of Developmental Sciences, St. George's University of London, London, United Kingdom;
authors: Aris
authors: A
authors: Papageorghiou
authors: Department of Obstetrics and Gynaecology, University of Brescia, Brescia, Italy.
authors: Federico
authors: F
authors: Prefumo
mesh_terms: D061085:Agenesis of Corpus Callosum / Q000150:complications* / Q000175:diagnosis; D002869:Chromosome Aberrations; D003072:Cognition Disorders / Q000209:etiology; D004827:Epilepsy / Q000209:etiology; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007806:Language Disorders / Q000209:etiology; D008279:Magnetic Resonance Imaging; D019957:Motor Skills Disorders / Q000209:etiology; D009483:Neuropsychological Tests; D011247:Pregnancy; D011296:Prenatal Diagnosis