title: Lipid profile, inflammation, and oxidative status in peri- and postmenopausal women.
abstract: OBJECTIVE
  To evaluate the effect of perimenopause and postmenopause on lipid profile, inflammation, and oxidative stress in women.
  
  
  METHODS
  This cross-sectional study included 117 women (47 ± 6 years) classified as perimenopausal (n = 47), postmenopausal (n = 40), or non-menopausal (n = 30). In serum, we analyzed lipid profile, tumor necrosis factor-alpha (TNF-α), interleukin-1α (IL-1α), and C-reactive protein (CRP). Pro-oxidant status was assessed by thiobarbituric acid reactive substances (TBARS) and protein carbonyls. Antioxidant defense was performed by analysis of superoxide dismutase (SOD) and catalase activities.
  
  
  RESULTS
  Compared to non-menopausal women, triacylglycerols (TG) were similar, total cholesterol and LDL-C were higher in perimenopausal and postmenopausal women, while HDL-C concentrations were decreased. TNF-α and IL-1α were higher in postmenopausal women, while CRP concentrations were elevated in both peri-and postmenopausal women (p < 0.05). TBARS and carbonyls were increased in peri- and postmenopausal women (p < 0.05). SOD and CAT activities were decreased in postmenopausal women (p < 0.05) and elevated in perimenopausal women.
  
  
  CONCLUSIONS
  Menopausal transition and postmenopause were associated with dyslipidemia, inflammation, and unbalanced oxidative status exposing women to cardiovascular risk.
authors: a Laboratoire de Nutrition Clinique et Métabolique, Département de Biologie, Faculté des Sciences de la Nature et de la Vie , Université d'Oran 1 Ahmed Benbella , Oran , Algérie.
authors: Ouarda
authors: O
authors: Taleb-Belkadi
authors: a Laboratoire de Nutrition Clinique et Métabolique, Département de Biologie, Faculté des Sciences de la Nature et de la Vie , Université d'Oran 1 Ahmed Benbella , Oran , Algérie.
authors: Hadjer
authors: H
authors: Chaib
authors: b Service d'épidémiologie, Etablissement Hospitalier Universitaire Oran , Oran , Algérie.
authors: Lakhdar
authors: L
authors: Zemour
authors: c Direction de la santé et de la population d'Oran , Oran , Algérie , and.
authors: Azzedine
authors: A
authors: Fatah
authors: d Service de Maternité. Etablissement Hospitalier Universitaire Oran , Oran , Algérie.
authors: Belkacem
authors: B
authors: Chafi
authors: a Laboratoire de Nutrition Clinique et Métabolique, Département de Biologie, Faculté des Sciences de la Nature et de la Vie , Université d'Oran 1 Ahmed Benbella , Oran , Algérie.
authors: Khedidja
authors: K
authors: Mekki
mesh_terms: D000328:Adult; D002784:Cholesterol / Q000097:blood; D003430:Cross-Sectional Studies; D016207:Cytokines / Q000097:blood; D005260:Female; D006801:Humans; D007249:Inflammation / Q000097:blood*; D008875:Middle Aged; D018384:Oxidative Stress / Q000502:physiology*; D047648:Perimenopause / Q000097:blood*; D017698:Postmenopause / Q000097:blood*; D014280:Triglycerides / Q000097:blood
chemical_list: D016207:Cytokines; D014280:Triglycerides; D002784:Cholesterol
keywords: Antioxidant defense; inflammation; perimenopause; postmenopause; pro-oxidant