title: Diastereodivergent Construction of Bicyclic γ-Lactones via Enantioselective Ketone Hydroacylation.
abstract: We present a diastereodivergent strategy for constructing bicyclic γ-lactones bearing quaternary carbon centers via ketone hydroacylation. By applying a Rh catalyst and JoSPOphos ligand, either the anti or syn bicyclic γ-lactones can be accessed with high enantio- and diastereoselectivities, depending on the choice of solvent, temperature, and counterion.
authors: Department of Chemistry, University of California, Irvine , 4403 Natural Sciences 1, Irvine, California 92697, United States.
authors: Xuesong
authors: X
authors: Wu
authors: Department of Chemistry, University of California, Irvine , 4403 Natural Sciences 1, Irvine, California 92697, United States.
authors: Zhiwei
authors: Z
authors: Chen
authors: Department of Chemistry, University of California, Irvine , 4403 Natural Sciences 1, Irvine, California 92697, United States.|College of Science, Northwest A&F University , Yangling, Shaanxi 712100, P. R. China.
authors: Yu-Bin
authors: YB
authors: Bai
authors: Department of Chemistry, University of California, Irvine , 4403 Natural Sciences 1, Irvine, California 92697, United States.
authors: Vy M
authors: VM
authors: Dong
mesh_terms: D000215:Acylation; D002384:Catalysis; D007659:Ketones / Q000737:chemistry*; D007783:Lactones / Q000138:chemical synthesis*; D015394:Molecular Structure; D012238:Rhodium; D013237:Stereoisomerism
chemical_list: D007659:Ketones; D007783:Lactones; D012238:Rhodium