title: Comparisons of clinicopathologic factors and survival rates between laparoscopic and open gastrectomy in gastric cancer.
abstract: OBJECTIVE
  This study examined the safety and facilitative aspects of laparoscopic gastrectomy, with respect to clinicopathologic factors and complications in patients with gastric cancer, in comparison with open gastrectomy. The study also compared the safety of laparoscopic gastrectomy, with respect to the 5-year survival rate and recurrence in terms of the oncologic results, with that of open gastrectomy.
  
  
  METHODS
  This retrospective study included 424 patients with gastric cancer who had undergone gastrectomy at Busan Paik Hospital, Inje University, over a 5-year period from January 2010 to December 2014. The gastric cancer database, comprising data collected from the patients' medical records, was examined for the analysis of clinicopathologic factors, complications, survival rates, and recurrence.
  
  
  RESULTS
  Of the 424 patients, 146 underwent laparoscopic gastrectomy and 278 underwent open gastrectomy. Differences were observed between laparoscopic and open gastrectomy with respect to clinicopathologic features such as tumor size, number of harvested lymph nodes, differentiation, T stage, N stage, TNM stage, lymphatic invasion, vascular invasion, and perineural invasion. The complication rates of laparoscopic and open gastrectomy were 4.8% and 4.3%, respectively, and the recurrence rates were 3.4% and 11.5%, respectively. The 5-year overall survival rates (OSRs) of laparoscopic and open gastrectomy were 90.5% and 85.9%, respectively, and the 5-year disease-free survival rates (DFSRs) were 90.2% and 75.6%, respectively, with significant differences. The 5-year OSRs of laparoscopic and open gastrectomy for stage I disease were 96.6% and 96.9%, respectively, those for stage II disease were 44.4% and 97.7%, respectively, and those for stage III disease were 75.0% and 61.7%, respectively. The 5-year DFSRs of laparoscopic and open gastrectomy for stage I disease were 95.4% and 96.9%, respectively, those for stage II disease were 60.6% and 84.9%, respectively, and those for stage III disease were 64.3% and 40.1%, respectively, with no significant difference.
  
  
  CONCLUSIONS
  This study showed that laparoscopic gastrectomy is a safe and beneficial modality compared with open gastrectomy in patients with gastric cancer. In terms of the oncologic results, laparoscopic gastrectomy is also considered safe and provides the same results as open gastrectomy.
authors: Department of Surgery, Busan Paik Hospital, Inje University, Republic of Korea.
authors: Dong Jun
authors: DJ
authors: Kim
authors: Department of Surgery, Busan Paik Hospital, Inje University, Republic of Korea.
authors: Sang Hyuk
authors: SH
authors: Seo
authors: Department of Surgery, Busan Paik Hospital, Inje University, Republic of Korea. Electronic address: inwoodog@naver.com.
authors: Kwang Hee
authors: KH
authors: Kim
authors: Department of Surgery, Busan Paik Hospital, Inje University, Republic of Korea.
authors: Yo-Han
authors: YH
authors: Park
authors: Department of Surgery, Busan Paik Hospital, Inje University, Republic of Korea.
authors: Min Sung
authors: MS
authors: An
authors: Department of Surgery, Busan Paik Hospital, Inje University, Republic of Korea.
authors: Ki Beom
authors: KB
authors: Bae
authors: Department of Surgery, Busan Paik Hospital, Inje University, Republic of Korea.
authors: Chang Soo
authors: CS
authors: Choi
authors: Department of Surgery, Busan Paik Hospital, Inje University, Republic of Korea.
authors: Sang Hoon
authors: SH
authors: Oh
mesh_terms: D000368:Aged; D018572:Disease-Free Survival; D005260:Female; D005743:Gastrectomy / Q000379:methods / Q000401:mortality*; D006801:Humans; D010535:Laparoscopy / Q000379:methods / Q000401:mortality*; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D012189:Retrospective Studies; D013274:Stomach Neoplasms / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D015996:Survival Rate; D016896:Treatment Outcome
keywords: 5-year disease-free survival rate; 5-year survival rate; Gastric cancer; Laparoscopic gastrectomy