title: Nocturnal Polyuria and Hypertension in Patients with Lifestyle Related Diseases and Overactive Bladder.
abstract: The objective of this multicenter cross-sectional study was to investigate the relationship of nocturnal polyuria in patients with common lifestyle related diseases and overactive bladder, with special attention to hypertension.
  
  
  
  After baseline assessment, patients recorded 24-hour urinary frequency/volume, blood pressure and heart rate for 3 days. They were stratified into 4 groups based on mean blood pressure, including no hypertension, and controllable, untreated and uncontrolled hypertension, respectively.
  
  
  
  The 2,353 eligible patients, who had urinary urgency once or more per week and 1 or more nocturnal toilet visits, were enrolled from 543 sites in Japan. Of these patients complete data, including the 24-hour frequency volume chart, were collected from 1,271. Multivariable analyses showed a statistically significant association of nocturnal polyuria with increasing age (OR 1.04, 95% CI 1.02-1.05, p <0.001) and gender (women vs men OR 0.75, 95% CI 0.59-0.96, p = 0.02), and for controllable (OR 1.10, 95% CI 0.83-1.460), untreated (OR 2.62, 95% CI 1.55-4.45) and uncontrolled (OR 1.15, 95% CI 0.81-1.62) hypertension vs no hypertension (p = 0.005). However, when assessed separately in men and women, hypertension and heart rate were significantly associated with nocturnal polyuria in women alone (p = 0.01 and 0.03, respectively). Lower urinary tract symptoms suggestive of benign prostatic hyperplasia were significantly associated with nocturnal polyuria in men alone (p <0.001).
  
  
  
  The current study demonstrates that nocturnal polyuria was significantly associated with age, male gender, and untreated hypertension in patients with lifestyle related diseases and overactive bladder. The association between hypertension and nocturnal polyuria was significant in women alone.
authors: Department of Urology, Faculty of Medical Science, University of Fukui, Fukui, Japan. Electronic address: oyoko@u-fukui.ac.jp.
authors: Osamu
authors: O
authors: Yokoyama
authors: North Alps Medical Center Azumi Hospital, Kitaazumi, Japan.
authors: Osamu
authors: O
authors: Nishizawa
authors: Department of Urology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan.
authors: Yukio
authors: Y
authors: Homma
authors: Department of Urology, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Chuo, Japan.
authors: Masayuki
authors: M
authors: Takeda
authors: Department of Urology, Nagoya University Graduate School of Medicine, Aichi, Japan.
authors: Momokazu
authors: M
authors: Gotoh
authors: Department of Renal and Urologic Surgery, Asahikawa Medical University, Asahikawa, Japan.
authors: Hidehiro
authors: H
authors: Kakizaki
authors: Department of Urology, Faculty of Medical Science, University of Fukui, Fukui, Japan.
authors: Hironobu
authors: H
authors: Akino
authors: Tokyo Dental College, Ichikawa General Hospital, Ichikawa, Japan.
authors: Koichi
authors: K
authors: Hayashi
authors: Biostatistics Center, Kurume University, Kurume, Japan.
authors: Koji
authors: K
authors: Yonemoto
mesh_terms: D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D003430:Cross-Sectional Studies; D005260:Female; D006339:Heart Rate; D006801:Humans; D006973:Hypertension / Q000453:epidemiology*; D007564:Japan / Q000453:epidemiology; D008019:Life Style; D008297:Male; D008875:Middle Aged; D053158:Nocturia / Q000453:epidemiology*; D011141:Polyuria / Q000453:epidemiology*; D015995:Prevalence; D011470:Prostatic Hyperplasia / Q000453:epidemiology*; D012737:Sex Factors; D053201:Urinary Bladder, Overactive / Q000453:epidemiology*
keywords: hypertension; life style; nocturia; overactive; polyuria; urinary bladder