title: Dopamine D1 and D3 receptor interactions in cocaine reward and seeking in rats.
abstract: Animal research has demonstrated a role of dopamine D1 and D3 receptors in cocaine reward and seeking.
  
  
  
  Here, we investigated the potential interaction of these two dopamine receptors in cue-induced reinstatement of cocaine seeking, cocaine conditioned place preference (CPP), and cocaine self-administration in rats.
  
  
  
  The co-administration of a D3 receptor antagonist, NGB 2904 and a D1 partial agonist, SKF 77434, of doses which when administered individually produced no significant effects, prior to reinstatement or CPP tests significantly reduced lever pressing and time spent in the cocaine-paired environment, suggesting synergistic effects of the combined compounds on cocaine seeking. When given to rats self-administering cocaine under a progressive ratio schedule of reinforcement doses of NGB 2904 which were ineffective alone significantly enhanced the break point-reducing effects of SKF 77434.
  
  
  
  Our results indicate that the combined treatment with a D1 receptor partial agonist and D3 receptor antagonist produces robust decreases in cocaine seeking and reward. This suggests an interaction between dopamine D1 and D3 receptors in cocaine-related behaviors.
authors: Neuropsychology Doctoral Program, The Graduate Center of the City University of New York, New York, NY, 10016, USA.
authors: E
authors: E
authors: Galaj
authors: Department of Chemistry, Hunter College, City University of New York, 695 Park Avenue, New York, NY, 10065, USA.|Program in Chemistry, The Graduate Center of the City University of New York, New York, NY, 10016, USA.|Program in Biochemistry, The Graduate Center of the City University of New York, New York, NY, 10016, USA.
authors: W
authors: W
authors: Harding
authors: Neuropsychology Doctoral Program, The Graduate Center of the City University of New York, New York, NY, 10016, USA. Robert.Ranaldi@qc.cuny.edu.|Department of Psychology, Queens College, City University of New York, 65-30 Kissena Blvd, Flushing, NY, 11367, USA. Robert.Ranaldi@qc.cuny.edu.|Psychology Department, Queens College, 65-30 Kissena Blvd, Flushing, NY, 11367, USA. Robert.Ranaldi@qc.cuny.edu.
authors: R
authors: R
authors: Ranaldi
mesh_terms: D000818:Animals; D003042:Cocaine / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D019970:Cocaine-Related Disorders / Q000188:drug therapy*; D004195:Disease Models, Animal; D018492:Dopamine Antagonists / Q000494:pharmacology*; D004359:Drug Therapy, Combination; D058999:Drug-Seeking Behavior / Q000187:drug effects*; D005449:Fluorenes / Q000494:pharmacology; D008297:Male; D010879:Piperazines / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D017447:Receptors, Dopamine D1 / Q000037:antagonists & inhibitors / Q000502:physiology*; D050637:Receptors, Dopamine D3 / Q000037:antagonists & inhibitors / Q000502:physiology*; D012054:Reinforcement, Psychology; D012201:Reward
chemical_list: D018492:Dopamine Antagonists; D005449:Fluorenes; C116818:NGB 2904; D010879:Piperazines; D017447:Receptors, Dopamine D1; D050637:Receptors, Dopamine D3; D003042:Cocaine
keywords: Cocaine; Conditioned place preference; D1 receptor partial agonist; D3 receptor antagonist; Reinstatement; Reward; Self-administration