title: Erlotinib plus bevacizumab as an effective treatment for leptomeningeal metastases from EGFR mutation-positive non-small cell lung cancer.
abstract: Leptomeningeal metastasis is a severe complication of non-small cell lung cancer. Its prognosis is very poor and conventional treatments have limited efficacy. However, epidermal growth factor receptor-tyrosine kinase inhibitors have exhibited high response rates in EGFR mutation-positive lung cancer patients with central nervous system metastases. It has been postulated that this could be due to the penetration of agents into the central nervous system and a high cerebrospinal fluid concentration is a key consideration in measuring treatment effect. Bevacizumab has also been used as an effective therapeutic agent in patients with central nervous system metastases. However, the efficacy of epidermal growth factor receptor-tyrosine kinase inhibitor doublet therapy for leptomeningeal metastases and the cerebrospinal fluid penetration of epidermal growth factor receptor-tyrosine kinase inhibitors have yet to be determined. Moreover, the safety of this doublet regimen in patients with a poor general condition is not known. Herein, we report on a case treated with erlotinib plus bevacizumab for leptomeningeal metastases from EGFR mutation-positive non-small cell lung cancer. The patient's performance status significantly improved and the cerebrospinal fluid penetration rate of erlotinib plus bevacizumab was equal to or greater than the past reports of erlotinib alone.
authors: Division of Respiratory Medicine, Saiseikai Kumamoto Hospital, Kumamoto 861-4193, Japan. Electronic address: yoshihiko-sakata@saiseikaikumamoto.jp.
authors: Yoshihiko
authors: Y
authors: Sakata
authors: Division of Respiratory Medicine, Saiseikai Kumamoto Hospital, Kumamoto 861-4193, Japan.
authors: Kodai
authors: K
authors: Kawamura
authors: Division of Respiratory Medicine, Saiseikai Kumamoto Hospital, Kumamoto 861-4193, Japan.
authors: Naoki
authors: N
authors: Shingu
authors: Division of Respiratory Medicine, Saiseikai Kumamoto Hospital, Kumamoto 861-4193, Japan.
authors: Kazuya
authors: K
authors: Ichikado
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use*; D000068258:Bevacizumab / Q000008:administration & dosage; D001921:Brain / Q000473:pathology; D002289:Carcinoma, Non-Small-Cell Lung / Q000175:diagnosis / Q000235:genetics* / Q000473:pathology*; D066246:ErbB Receptors / Q000235:genetics*; D000069347:Erlotinib Hydrochloride / Q000008:administration & dosage; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000175:diagnosis / Q000235:genetics* / Q000473:pathology*; D008577:Meningeal Neoplasms / Q000175:diagnosis / Q000188:drug therapy* / Q000556:secondary*; D008875:Middle Aged; D009154:Mutation; D009367:Neoplasm Staging; D000072078:Positron Emission Tomography Computed Tomography; D016896:Treatment Outcome
chemical_list: D000068258:Bevacizumab; D000069347:Erlotinib Hydrochloride; D066246:ErbB Receptors
keywords: Bevacizumab; Cerebrospinal fluid; EGFR mutation; Erlotinib; Leptomeningeal metastasis; Non-small cell lung cancer