title: Association between MTHFR gene 1298A>C polymorphism and breast cancer susceptibility: a meta-analysis based on 38 case-control studies with 40,985 subjects.
abstract: BACKGROUND
  Studies investigating the association between the methylenetetrahydrofolate reductase (MTHFR) gene 1298A>C polymorphism and the risk of breast cancer have reported inconsistent results. So, we performed this updated meta-analysis and tried to give a more precise estimation of association between MTHFR gene 1298A>C polymorphism and breast cancer susceptibility.
  
  
  METHODS
  Relevant studies published before 1 January 2016 were identified by searching PubMed and EMBASE. The strength of relationship between the MTHFR gene 1298A>C polymorphism and breast cancer susceptibility was assessed using odds ratio (OR) and corresponding 95 % confidence interval (95 % CI). The meta-analysis was performed using Stata 11.0 software.
  
  
  RESULTS
  A total number of 38 case-control studies including 18,686 cases and 22,299 controls were identified. No association was found in five genetic models (dominant model: OR = 0.99, 95 % CI 0.99-1.00, P = 0.218; recessive model: OR = 1.00, 95 % CI 0.97-1.02, P = 0.880; homozygote genetic model: OR = 0.99, 95 % CI 0.98-1.01, P = 0.390; heterozygote genetic model: OR = 0.99, 95 % CI 0.97-1.00, P = 0.138; and allele contrast genetic model: OR = 0.99, 95 % CI 0.98-1.01) for MTHFR gene 1298 A>C polymorphism and breast cancer susceptibility. In the subgroup analysis stratified by source of control, decreased risk of breast cancer was found in studies with hospital-based controls in dominant model (OR = 0.98, 95 % CI 0.96-1.00, P = 0.037).
  
  
  CONCLUSIONS
  Our meta-analysis suggested that there is no significant association between MTHFR gene 1298A>C polymorphism and breast cancer susceptibility for overall population.
authors: Department of General Surgery, Beijing TongRen Hospital, No.1 Jia Dong Jiao Min Xiang, Dongcheng District, Beijing, 100730, China.
authors: Jinghong
authors: J
authors: Zhang
authors: Department of General Surgery, Beijing TongRen Hospital, No.1 Jia Dong Jiao Min Xiang, Dongcheng District, Beijing, 100730, China.
authors: Lijun
authors: L
authors: Zhang
authors: Department of General Surgery, Beijing TongRen Hospital, No.1 Jia Dong Jiao Min Xiang, Dongcheng District, Beijing, 100730, China. liguangming_lgm16@163.com.
authors: Guangming
authors: G
authors: Li
mesh_terms: D001943:Breast Neoplasms / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D042965:Methylenetetrahydrofolate Reductase (NADPH2) / Q000235:genetics*; D008957:Models, Genetic; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors
chemical_list: C573423:MTHFR protein, human; D042965:Methylenetetrahydrofolate Reductase (NADPH2)
keywords: Breast cancer; Gene polymorphism; MTHFR gene 1298A>C polymorphism; Meta-analysis; One-carbon metabolism; Variant