title: Late-Onset Asthma Predicts Cardiovascular Disease Events: The Wisconsin Sleep Cohort.
abstract: Asthma is a heterogeneous syndrome with different clinical subtypes that is associated with an increased risk for cardiovascular disease (CVD). We hypothesized that the late-onset subtype of asthma is associated with a higher risk of incident CVD.
  
  
  
  Participants from the Wisconsin Sleep Cohort free of CVD at baseline were followed for a mean (SD) of 13.9 (5.9) years for development of CVD (myocardial infarction, angina, stroke, coronary revascularization, heart failure, or CVD death). Late-onset asthma was defined as physician-diagnosed asthma at age ≥18 years. Multivariable Cox regression models adjusted for age, sex, and CVD risk factors were used to assess associations of late-onset asthma and incident CVD. The 1269 participants were 47.3 (8.0) years old; 166 participants had asthma (111 late-onset, 55 early-onset). Participants with late-onset asthma compared to nonasthmatics were more likely to be female (67% versus 44%) and to have a higher body-mass index (32.2 versus 29.4 kg/m(2)) (P<0.05). Mean age of asthma diagnosis in the late-onset group was 39.5 (9.6) years versus 8.9 (5.7) years in the early-onset group (P<0.0001). Late-onset asthmatics had a higher adjusted risk of incident CVD than nonasthmatics (hazard ratio 1.57, 95% CI 1.01-2.45, P=0.045). There was no interaction between body-mass index and age of asthma diagnosis on incident CVD (P=0.83).
  
  
  
  In a large cohort study of adults followed prospectively for over a decade, late-onset asthmatics had an increased risk of incident CVD events that persisted after adjustment for age, sex, and CVD risk factors.
authors: Division of Cardiovascular Medicine, Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI.
authors: Matthew C
authors: MC
authors: Tattersall
authors: Department of Population Health, University of Wisconsin School of Medicine and Public Health, Madison, WI.
authors: Jodi H
authors: JH
authors: Barnet
authors: Division of Cardiovascular Medicine, Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI.
authors: Claudia E
authors: CE
authors: Korcarz
authors: Department of Population Health, University of Wisconsin School of Medicine and Public Health, Madison, WI.
authors: Erika W
authors: EW
authors: Hagen
authors: Department of Population Health, University of Wisconsin School of Medicine and Public Health, Madison, WI.
authors: Paul E
authors: PE
authors: Peppard
authors: Division of Cardiovascular Medicine, Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI jhs@medicine.wisc.edu.
authors: James H
authors: JH
authors: Stein
mesh_terms: D000328:Adult; D017668:Age of Onset; D000787:Angina Pectoris / Q000453:epidemiology; D001249:Asthma / Q000453:epidemiology*; D015992:Body Mass Index; D002318:Cardiovascular Diseases / Q000453:epidemiology / Q000401:mortality*; D016022:Case-Control Studies; D015331:Cohort Studies; D005260:Female; D006333:Heart Failure / Q000453:epidemiology; D006801:Humans; D000067562:Late Onset Disorders / Q000453:epidemiology*; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009203:Myocardial Infarction / Q000453:epidemiology; D009204:Myocardial Revascularization / Q000706:statistics & numerical data; D009765:Obesity / Q000453:epidemiology; D016016:Proportional Hazards Models; D012307:Risk Factors; D012737:Sex Factors; D020521:Stroke / Q000453:epidemiology; D014922:Wisconsin / Q000453:epidemiology
keywords: asthma; atherosclerosis; epidemiology; risk factors