title: C-reactive protein levels and genetic variants of CRP as prognostic markers for combined cardiovascular endpoint (cardiovascular death, death from stroke, myocardial infarction, and stroke/TIA).
abstract: The aim of this analysis was to evaluate the importance of C-reactive protein levels and genetic variants of CRP as prognostic markers for further cardiovascular (CV) events (3-year follow-up) in a cohort of in-patients with cardiovascular disease (CVD) patients.
  
  
  
  Patients with angiographic proven CVD (n=939) were prospectively included. The three-year CV outcome of the patients was evaluated considering the predefined, combined endpoint (CV death, death from stroke, myocardial infarction, and stroke/TIA). Polymorphisms rs1800947, rs1417938, rs1130864, rs3093077 were analysed. In Kaplan-Meier survival curve and Cox regression increased CRP levels of ⩾5mg/l (log-rank test: p=0.001, Cox regression: hazard ratio=1.77, 95% CI: 1.2-2.7) and the GG genotype of rs1800947 (log-rank test: p=0.01, Cox regression: hazard ratio=1.99, 95% CI: 1.1-3.6) were associated with the incidence of the combined endpoint.
  
  
  
  Both a CRP level ⩾5mg/l and SNP rs1800947 of the CRP gene were independent risk factors for further adverse CV events among patients with CVD within three years follow-up.
authors: Department of Operative Dentistry and Periodontology, Martin-Luther University Halle-Wittenberg, Germany. Electronic address: susanne.schulz@medizin.uni-halle.de.
authors: Susanne
authors: S
authors: Schulz
authors: Department of Operative Dentistry and Periodontology, Martin-Luther University Halle-Wittenberg, Germany.
authors: Henriette
authors: H
authors: Lüdike
authors: Department of Operative Dentistry and Periodontology, Martin-Luther University Halle-Wittenberg, Germany.
authors: Madlen
authors: M
authors: Lierath
authors: Department of Medicine III, Heart Centre of the University Clinics Halle (Saale), Martin-Luther University Halle-Wittenberg, Germany; Department of Cardiology, Paracelsus-Harz-Clinic Bad Suderode, Germany.
authors: Axel
authors: A
authors: Schlitt
authors: Department of Medicine III, Heart Centre of the University Clinics Halle (Saale), Martin-Luther University Halle-Wittenberg, Germany.
authors: Karl
authors: K
authors: Werdan
authors: Department of Cardiothoracic Surgery, Heart Centre of the University Clinics Halle (Saale), Martin-Luther University Halle-Wittenberg, Germany.
authors: Britt
authors: B
authors: Hofmann
authors: Institute of Human Genetics and Medical Biology, Martin-Luther University Halle-Wittenberg, Germany.
authors: Christiane
authors: C
authors: Gläser
authors: Department of Operative Dentistry and Periodontology, Martin-Luther University Halle-Wittenberg, Germany.
authors: Hans-Günter
authors: HG
authors: Schaller
authors: Department of Operative Dentistry and Periodontology, Martin-Luther University Halle-Wittenberg, Germany.
authors: Stefan
authors: S
authors: Reichert
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002097:C-Reactive Protein / Q000235:genetics*; D003643:Death; D018572:Disease-Free Survival; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000235:genetics / Q000401:mortality; D020641:Polymorphism, Single Nucleotide; D020521:Stroke / Q000235:genetics / Q000401:mortality; D015996:Survival Rate
chemical_list: D002097:C-Reactive Protein
keywords: C-reactive protein; Coronary vascular disease; Genetics; Prognostic factor