title: Structural investigations into the binding mode of a novel noscapine analogue, 9-(4-vinylphenyl) noscapine, with tubulin by biochemical analyses and molecular dynamic simulations.
authors: a Experimental Cancer Therapeutics and Chemical Biology, UM-DAE Centre for Excellence in Basic Sciences , University of Mumbai Kalina Campus , Santacruz (E), Mumbai 400098 , India.
authors: Tejashree
authors: T
authors: Mahaddalkar
authors: b Department of Biotechnology , Guru Ghasidas Central University , Bilaspur , Chattisgarh 495009 , India.
authors: Pradeep Kumar
authors: PK
authors: Naik
authors: a Experimental Cancer Therapeutics and Chemical Biology, UM-DAE Centre for Excellence in Basic Sciences , University of Mumbai Kalina Campus , Santacruz (E), Mumbai 400098 , India.
authors: Sinjan
authors: S
authors: Choudhary
authors: c Organic Chemistry Division-II (CPC Division) , CSIR-Indian Institute of Chemical Technology , Hyderabad , Telangana 500007 , India.
authors: Naresh
authors: N
authors: Manchukonda
authors: c Organic Chemistry Division-II (CPC Division) , CSIR-Indian Institute of Chemical Technology , Hyderabad , Telangana 500007 , India.
authors: Srinivas
authors: S
authors: Kantevari
authors: a Experimental Cancer Therapeutics and Chemical Biology, UM-DAE Centre for Excellence in Basic Sciences , University of Mumbai Kalina Campus , Santacruz (E), Mumbai 400098 , India.
authors: Manu
authors: M
authors: Lopus
mesh_terms: D000996:Antitussive Agents / Q000737:chemistry / Q000378:metabolism*; D006801:Humans; D008870:Microtubules / Q000737:chemistry / Q000378:metabolism; D008958:Models, Molecular; D056004:Molecular Dynamics Simulation; D009665:Noscapine / Q000031:analogs & derivatives / Q000737:chemistry / Q000378:metabolism*; D011485:Protein Binding; D014404:Tubulin / Q000737:chemistry / Q000378:metabolism*
chemical_list: D000996:Antitussive Agents; D014404:Tubulin; D009665:Noscapine
keywords: 9-(4-vinylphenyl) noscapine; microtubules; molecular dynamic simulations; noscapine; tubulin isotypes; βIII tubulin