title: Efficient synthesis and antioxidant activities of N-heterocyclyl substituted Coenzyme Q analogues.
abstract: A new strategy for the efficient synthesis of C-5 heterocyclyl substituted Coenzyme Q analogues was developed by N-alkylation of bromomethylated quinone 11 with a series of amines 12 under metal-free conditions. In vitro antioxidant activities of these Coenzyme Q analogues were evaluated and compared with commercial antioxidant Coenzyme Q10 by employing DPPH assay. All these N-heterocyclyl substituted Coenzyme Q analogues are found to be exhibiting good antioxidant properties and may be used as potent antioxidants for combating oxidative stress.
authors: School of Pharmacy, Yancheng Teachers University, Yancheng 224051, Jiangsu Province, PR China. Electronic address: woongching@hotmail.com.
authors: Jin
authors: J
authors: Wang
authors: School of Pharmacy, Yancheng Teachers University, Yancheng 224051, Jiangsu Province, PR China.
authors: Fei
authors: F
authors: Xia
authors: School of Pharmacy, Yancheng Teachers University, Yancheng 224051, Jiangsu Province, PR China.
authors: Wen-Bin
authors: WB
authors: Jin
authors: School of Pharmacy, Yancheng Teachers University, Yancheng 224051, Jiangsu Province, PR China.
authors: Jin-Yan
authors: JY
authors: Guan
authors: School of Pharmacy, Yancheng Teachers University, Yancheng 224051, Jiangsu Province, PR China.
authors: Hang
authors: H
authors: Zhao
mesh_terms: D000975:Antioxidants / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D006571:Heterocyclic Compounds / Q000737:chemistry / Q000494:pharmacology*; D015394:Molecular Structure; D018384:Oxidative Stress / Q000187:drug effects; D013329:Structure-Activity Relationship; D014451:Ubiquinone / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000975:Antioxidants; D006571:Heterocyclic Compounds; D014451:Ubiquinone
keywords: Antioxidant activities; CoQ analogues; DPPH assay; N-alkylation