title: Efficacy of ultrasound-guided core needle gun biopsy in diagnosing cervical lymphadenopathy.
abstract: OBJECTIVE
  Ultrasound-guided fine needle aspiration cytology (US-FNA) is useful for diagnosing cervical lymphadenopathy. However, FNA, has a high false negative rate, especially in patients with lymphoma. Ultrasound-guided core needle gun biopsy (US-CNB) has recently become important for diagnosing cancers, but its value remains undetermined. This study evaluates the efficacy of US-CNB, performed in an outpatient setting, in diagnosing cervical lymphadenopathy and the spectrum of related diseases.
  
  
  METHODS
  This retrospective study included 79 subjects who were not squamous cell carcinoma suspects and did not have a history of malignancy between January 2006 and July 2009. A US-CNB was performed on enlarged cervical lymph nodes (>1.0cm) in all subjects. Diagnostic sensitivity, specificity, and accuracy of US-CNB in differentiating between malignant and benign lymphadenopathy were evaluated. All enrolled subjects underwent a planned US-FNA before the study US-CNB was performed. Results of US-CNB and US-FNA were compared.
  
  
  RESULTS
  The correct histopathological diagnoses were made in 73 of 79 subjects (91.1%) using US-CNB samples. Of these, the most common diagnoses were reactive hyperplasia (26 subjects), Kikuchi's disease (17 subjects), tuberculous lymphadenitis (15 subjects), lymphoma (8 subjects), and metastatic carcinoma (3 subjects). The US-CNB was very good at differentiating between malignant and benign lymphadenopathy, with a diagnostic sensitivity, specificity, and accuracy of 91.6%, 100%, and 98.6%, respectively. Additionally, US-CNB was more accurate than US-FNA in identifying lymphoma (88.8% vs. 11.1%) and Kikuchi's disease (89.4% vs. 29.4%). No US-CNB related-complications were observed.
  
  
  CONCLUSIONS
  The US-CNB is safe, effective, and has a high diagnostic yield for cervical lymphadenopathy. The US-CNB may also be useful for diagnosing lymphoma and Kikuchi's disease.
authors: Department of Otorhinolaryngology-Head and Neck Surgery, Korea University College of Medicine, 123 Jeokgeum-ro (Gojan-dong), Danwon-gu, Ansan-si, Gyeonggi-do 425-707, Republic of Korea.
authors: K H
authors: KH
authors: Oh
authors: Department of Otorhinolaryngology-Head and Neck Surgery, Korea University College of Medicine, 123 Jeokgeum-ro (Gojan-dong), Danwon-gu, Ansan-si, Gyeonggi-do 425-707, Republic of Korea.
authors: J S
authors: JS
authors: Woo
authors: Department of Otorhinolaryngology-Head and Neck Surgery, Korea University College of Medicine, 123 Jeokgeum-ro (Gojan-dong), Danwon-gu, Ansan-si, Gyeonggi-do 425-707, Republic of Korea.
authors: J G
authors: JG
authors: Cho
authors: Department of Otorhinolaryngology-Head and Neck Surgery, Korea University College of Medicine, 123 Jeokgeum-ro (Gojan-dong), Danwon-gu, Ansan-si, Gyeonggi-do 425-707, Republic of Korea.
authors: S K
authors: SK
authors: Baek
authors: Department of Otorhinolaryngology-Head and Neck Surgery, Korea University College of Medicine, 123 Jeokgeum-ro (Gojan-dong), Danwon-gu, Ansan-si, Gyeonggi-do 425-707, Republic of Korea.
authors: K Y
authors: KY
authors: Jung
authors: Department of Otorhinolaryngology-Head and Neck Surgery, Korea University College of Medicine, 123 Jeokgeum-ro (Gojan-dong), Danwon-gu, Ansan-si, Gyeonggi-do 425-707, Republic of Korea. Electronic address: entkwon@korea.ac.kr.
authors: S Y
authors: SY
authors: Kwon
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D044963:Biopsy, Fine-Needle; D062005:Biopsy, Large-Core Needle / Q000379:methods*; D002648:Child; D005260:Female; D020042:Histiocytic Necrotizing Lymphadenitis / Q000175:diagnosis; D006801:Humans; D000072281:Lymphadenopathy / Q000175:diagnosis* / Q000209:etiology; D008223:Lymphoma / Q000175:diagnosis; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis / Q000175:diagnosis; D019310:Pseudolymphoma / Q000175:diagnosis; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D014388:Tuberculosis, Lymph Node / Q000175:diagnosis; D018084:Ultrasonography, Interventional; D055815:Young Adult
keywords: Core needle gun biopsy; Fine needle aspiration; Lymphadenopathy