title: Asymmetric Allylation/RCM-Mediated Synthesis of Fluorinated Benzo-Fused Bicyclic Homoallylic Amines As Dihydronaphthalene Derivatives.
abstract: Enantiomerically enriched fluorinated benzo-fused bicyclic homoallylic amines have been synthesized through an asymmetric allylation/ring closing metathesis (RCM) sequence. This sequence has been carried out using α-trifluoromethylstyrene derivatives as key intermediates, synthesized by microwave radiation. The great deactivating effect exerted by such substituents has been brought to light by a comparative study.
authors: Departamento de Química Orgánica, Universidad de Valencia , E-46100 Burjassot, Spain.
authors: Daniel M
authors: DM
authors: Sedgwick
authors: Departamento de Química Orgánica, Universidad de Valencia , E-46100 Burjassot, Spain.
authors: Pablo
authors: P
authors: Barrio
authors: Departamento de Química Orgánica, Universidad de Valencia , E-46100 Burjassot, Spain.
authors: Antonio
authors: A
authors: Simón
authors: Laboratorio de Moléculas Orgánicas, Centro de Investigación Príncipe Felipe , E-46012 Valencia, Spain.
authors: Raquel
authors: R
authors: Román
authors: Departamento de Química Orgánica, Universidad de Valencia , E-46100 Burjassot, Spain.|Laboratorio de Moléculas Orgánicas, Centro de Investigación Príncipe Felipe , E-46012 Valencia, Spain.
authors: Santos
authors: S
authors: Fustero