title: Coronary Plaque Characteristics Assessed by 256-Slice Coronary CT Angiography and Association with High-Sensitivity C-Reactive Protein in Symptomatic Patients with Type 2 Diabetes.
abstract: Little is known regarding plaque distribution, composition, and the association with inflammation in type 2 diabetes mellitus (DM2). This study aimed to assess the relationship between coronary plaque subtypes and high-sensitivity C-reactive protein levels. Coronary CTA were performed in 98 symptomatic DM2 patients and 107 non-DM2 patients using a 256-slice CT. The extent and types of plaque as well as luminal narrowing were evaluated. Patients with DM2 were more likely to have significant stenosis (>50%) with calcified plaques in at least one coronary segment (p < 0.01); the prevalence rates of diffuse calcified plaques in the DM2 and non-DM2 groups were 31.6% and 4.7%, respectively (p < 0.01). Plasma hs-CRP levels in DM2 with calcified plaques were higher compared with values obtained for the non-DM2 group (p < 0.01). In conclusion, combination of coronary CTA and hs-CRP might improve risk stratification in symptomatic DM2 patients.
authors: Department of CT, The Second Affiliated Hospital of Harbin Medical University, Harbin 150086, China.
authors: Jinling
authors: J
authors: Zhang
authors: Department of CT, The Second Affiliated Hospital of Harbin Medical University, Harbin 150086, China.
authors: Zhehao
authors: Z
authors: Lv
authors: Department of CT, The Second Affiliated Hospital of Harbin Medical University, Harbin 150086, China.
authors: Deli
authors: D
authors: Zhao
authors: Department of CT, The Second Affiliated Hospital of Harbin Medical University, Harbin 150086, China.
authors: Lili
authors: L
authors: Liu
authors: Department of CT, The Second Affiliated Hospital of Harbin Medical University, Harbin 150086, China.
authors: Yong
authors: Y
authors: Wan
authors: Department of CT, The Second Affiliated Hospital of Harbin Medical University, Harbin 150086, China.
authors: Tingting
authors: T
authors: Fan
authors: Department of CT, The Second Affiliated Hospital of Harbin Medical University, Harbin 150086, China.
authors: Huimin
authors: H
authors: Li
authors: Department of CT, The Second Affiliated Hospital of Harbin Medical University, Harbin 150086, China.
authors: Ying
authors: Y
authors: Guan
authors: Department of CT, The Second Affiliated Hospital of Harbin Medical University, Harbin 150086, China.
authors: Bailu
authors: B
authors: Liu
authors: Department of Radiology, Xuanwu Hospital, Beijing 100053, China; Biomedical Imaging Research Institute, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA.
authors: Qi
authors: 0000-0002-5773-0456
authors: Q
authors: Yang
mesh_terms: D000328:Adult; D002097:C-Reactive Protein / Q000378:metabolism*; D016022:Case-Control Studies; D000072226:Computed Tomography Angiography; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000000981:diagnostic imaging* / Q000453:epidemiology / Q000378:metabolism; D023921:Coronary Stenosis / Q000000981:diagnostic imaging* / Q000453:epidemiology / Q000378:metabolism; D003924:Diabetes Mellitus, Type 2 / Q000453:epidemiology / Q000378:metabolism*; D005260:Female; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D016017:Odds Ratio; D058226:Plaque, Atherosclerotic / Q000000981:diagnostic imaging* / Q000453:epidemiology / Q000378:metabolism; D015995:Prevalence; D061205:Vascular Calcification / Q000000981:diagnostic imaging* / Q000453:epidemiology / Q000378:metabolism
chemical_list: D002097:C-Reactive Protein