title: Associations between Thyroid Stimulating Hormone Levels and Both Severity and Early Outcome of Patients with Ischemic Stroke.
abstract: We aimed to investigate associations between serum thyroid stimulating hormone (TSH) levels and both severity and outcome after ischemic stroke (IS). A total of 731 patients consecutive IS patients were enrolled (mean age 69.4 ± 15.4, 61.6% men), and serum TSH levels were measured at admission and analyzed according to the tertiles of their distribution (<0.822 vs. 0.822-1.6 vs. >1.6 mUI/l). Associations between TSH and both severity at admission (National Institutes of Health Stroke Scale (NIHSS) scores <5 vs. ≥5) and functional outcome at discharge assessed by the modified Rankin Scale were analyzed using logistic regression and ordinal logistic regression models, respectively. High TSH levels were independently associated with both a decreased risk of NIHSS score ≥5 at admission (prevalence proportion ratio = 0.62; 95% CI 0.41-0.94, p = 0.024 for tertile 3 vs. tertile 1). In addition, patients with high TSH levels had a better functional outcome at discharge (OR 0.43; 95% CI 0.30-0.60, p < 0.001 for tertile 2 vs. tertile 1; OR 0.39; 95% CI 0.27-0.56, p < 0.001 for tertile 3 vs. tertile 1). The mechanisms underlying these associations and their potential exploitation in terms of therapeutic strategies need to be explored.
authors: Department of Neurology, Dijon Stroke Registry, University Hospital and Medical School of Dijon, University of Bourgogne, Dijon, France.
authors: Benoit
authors: B
authors: Delpont
authors: Corine
authors: C
authors: Aboa-Eboulé
authors: Jérôme
authors: J
authors: Durier
authors: Jean-Michel
authors: JM
authors: Petit
authors: Anaïs
authors: A
authors: Daumas
authors: Nicolas
authors: N
authors: Legris
authors: Benoit
authors: B
authors: Daubail
authors: Maurice
authors: M
authors: Giroud
authors: Yannick
authors: Y
authors: Béjot
mesh_terms: D000208:Acute Disease; D000368:Aged; D000369:Aged, 80 and over; D002544:Cerebral Infarction / Q000097:blood* / Q000175:diagnosis* / Q000628:therapy; D004185:Disability Evaluation; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012720:Severity of Illness Index; D013972:Thyrotropin / Q000097:blood*; D016896:Treatment Outcome
chemical_list: D013972:Thyrotropin