title: Inhibition of E. coli and S. aureus with selenium nanoparticles synthesized by pulsed laser ablation in deionized water.
abstract: Nosocomial diseases are mainly caused by two common pathogens, Escherichia coli and Staphylococcus aureus, which are becoming more and more resistant to conventional antibiotics. Therefore, it is becoming increasingly necessary to find other alternative treatments than commonly utilized drugs. A promising strategy is to use nanomaterials such as selenium nanoparticles. However, the ability to produce nanoparticles free of any contamination is very challenging, especially for nano-medical applications. This paper reports the successful synthesis of pure selenium nanoparticles by laser ablation in water and determines the minimal concentration required for ~50% inhibition of either E. coli or S. aureus after 24 hours to be at least ~50 ppm. Total inhibition of E. coli and S. aureus is expected to occur at 107±12 and 79±4 ppm, respectively. In this manner, this study reports for the first time an easy synthesis process for creating pure selenium to inhibit bacterial growth.
authors: Department of Physics and Astronomy, The University of Texas at San Antonio, San Antonio, TX.
authors: G
authors: G
authors: Guisbiers
authors: Department of Bioengineering.
authors: Q
authors: Q
authors: Wang
authors: Department of Physics and Astronomy, The University of Texas at San Antonio, San Antonio, TX.
authors: E
authors: E
authors: Khachatryan
authors: Department of Physics and Astronomy, The University of Texas at San Antonio, San Antonio, TX.
authors: L C
authors: LC
authors: Mimun
authors: Department of Physics and Astronomy, The University of Texas at San Antonio, San Antonio, TX.
authors: R
authors: R
authors: Mendoza-Cruz
authors: Department of Civil and Environmental Engineering.
authors: P
authors: P
authors: Larese-Casanova
authors: Department of Bioengineering; Department of Chemical Engineering, Northeastern University, Boston, MA, USA; Center of Excellence for Advanced Materials Research, King Abdulaziz University, Jeddah, Saudi Arabia.
authors: T J
authors: TJ
authors: Webster
authors: Department of Physics and Astronomy, The University of Texas at San Antonio, San Antonio, TX.
authors: K L
authors: KL
authors: Nash
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D004926:Escherichia coli / Q000187:drug effects*; D007834:Lasers; D008826:Microbial Sensitivity Tests; D053758:Nanoparticles / Q000737:chemistry; D012643:Selenium / Q000737:chemistry / Q000494:pharmacology*; D013211:Staphylococcus aureus / Q000187:drug effects*; D014867:Water / Q000737:chemistry
chemical_list: D000900:Anti-Bacterial Agents; D014867:Water; D012643:Selenium
keywords: antibiotics resistant; bacteria; cytotoxicity; nosocomial disease