title: CTNND1755 T>G Promoter Polymorphism and Risk of Pancreatic Carcinoma in Chinese.
abstract: OBJECTIVE
  To investigate the relationship between 755 T>G polymorphisms in the CTNND1gene, which is associated with the risk of pancreatic carcinoma in Chinese.
  
  
  METHODS
  CTNND1755 T>G genotypes were determined by PCR-RFLP in 122 pancreatic carcinoma patients and 180 healthy controls matched for age and sex, who did not receive radiotherapy or chemotherapy for newly diagnosed and histopathologically confirmed pancreatic carcinoma.
  
  
  RESULTS
  In control subjects, the frequency of T/T and G/T genotypes, and T and G alleles was 79.4%, 17.2%, 88.1%, and 11.9%, respectively. The distribution of genotypes and allelotypes in the pancreatic carcinoma patients was significantly different from that in the controls (P = 0.007, P = 0.012). Combined GG and GT genotypes were found to have a higher OR in male pancreatic carcinoma patients and the group under the age of 70 years (males: OR, 1.409; 95%CI, 0.912~1.921; under 70 years: OR 1.626; 95% CI, 0.878~2.312). This study also showed a distinct difference in the distribution of P120ctn and single nucleotide polymorphisms (SNPs) between Chinese and Canadian (11.9% vs. 3.9%, P = 0.008).
  
  
  CONCLUSIONS
  CTNND1755 T>G polymorphism may be a stratification marker to predict the susceptibility to pancreatic carcinoma, at least in Chinese. CTNND1promoter SNPs is diverse in ethnic populations.
authors: Department of General Surgery, Bayi Hospital Affiliated Nanjing University of Chinese Medicine/The 81st Hospital of P.L.A., Nanjing, China.
authors: Wei
authors: W
authors: Wang
authors: Department of General Surgery, Bayi Hospital Affiliated Nanjing University of Chinese Medicine/The 81st Hospital of P.L.A., Nanjing, China.
authors: Yang
authors: Y
authors: Fei
authors: Department of General Surgery, ZhongDa Hospital, The Affiliated Hospital of Southeast University, Nanjing, China.
authors: Sheng-Li
authors: SL
authors: Liu
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D044466:Asian People / Q000235:genetics*; D016022:Case-Control Studies; D051177:Catenins / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D008875:Middle Aged; D010190:Pancreatic Neoplasms / Q000453:epidemiology* / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D000095002:Delta Catenin
chemical_list: D051177:Catenins; D000095002:Delta Catenin; C000722347:CTNND1 protein, human
keywords: 
  CTNND
  1
  ; gene polymorphism; pancreatic carcinoma