title: Immunological processes related to cognitive impairment in MS.
abstract: In this review, the immune-to-brain communication pathways are briefly summarized, with emphasis on the impact of immune cells and their mediators on learning, memory and other cognitive domains. Further, the acute response of the central nervous system to peripherally generated inflammatory stimuli - termed as sickness behaviour - is described, and the central role of microglia in this immune-to-brain crosstalk in physiological and pathological conditions is highlighted. Finally, the role and consequences of immunological processes related to cognitive impairment in multiple sclerosis are discussed.
authors: Clinical Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria.
authors: T
authors: T
authors: Berger
mesh_terms: D060825:Cognitive Dysfunction / Q000209:etiology / Q000276:immunology*; D006801:Humans; D009103:Multiple Sclerosis / Q000150:complications / Q000276:immunology*
keywords: cognition; cognitive impairment; immunology; multiple sclerosis; sickness behaviour