title: CD301b(+) Mononuclear Phagocytes Maintain Positive Energy Balance through Secretion of Resistin-like Molecule Alpha.
abstract: Mononuclear phagocytes (MNPs) are a highly heterogeneous group of cells that play important roles in maintaining the body's homeostasis. Here, we found CD301b (also known as MGL2), a lectin commonly used as a marker for alternatively activated macrophages, was selectively expressed by a subset of CD11b(+)CD11c(+)MHCII(+) MNPs in multiple organs including adipose tissues. Depleting CD301b(+) MNPs in vivo led to a significant weight loss with increased insulin sensitivity and a marked reduction in serum Resistin-like molecule (RELM) α, a multifunctional cytokine produced by MNPs. Reconstituting RELMα in CD301b(+) MNP-depleted animals restored body weight and normoglycemia. Thus, CD301b(+) MNPs play crucial roles in maintaining glucose metabolism and net energy balance.
authors: Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06510, USA.
authors: Yosuke
authors: Y
authors: Kumamoto
authors: Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06510, USA.
authors: Joao Paulo G
authors: JPG
authors: Camporez
authors: Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06510, USA.
authors: Michael J
authors: MJ
authors: Jurczak
authors: Section of Comparative Medicine, Yale University School of Medicine, New Haven, CT 06510, USA.
authors: Marya
authors: M
authors: Shanabrough
authors: Section of Comparative Medicine, Yale University School of Medicine, New Haven, CT 06510, USA.
authors: Tamas
authors: T
authors: Horvath
authors: Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06510, USA; Howard Hughes Medical Institute, Chevy Chase, MD 20815-6789, USA.
authors: Gerald I
authors: GI
authors: Shulman
authors: Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06510, USA; Howard Hughes Medical Institute, Chevy Chase, MD 20815-6789, USA. Electronic address: akiko.iwasaki@yale.edu.
authors: Akiko
authors: A
authors: Iwasaki
mesh_terms: D000273:Adipose Tissue / Q000378:metabolism; D000818:Animals; D004734:Energy Metabolism / Q000502:physiology*; D005260:Female; D005947:Glucose; D007328:Insulin / Q000378:metabolism; D007333:Insulin Resistance / Q000502:physiology; D036341:Intercellular Signaling Peptides and Proteins / Q000378:metabolism*; D037181:Lectins, C-Type / Q000378:metabolism*; D008264:Macrophages / Q000378:metabolism; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D010586:Phagocytes / Q000378:metabolism*
chemical_list: D007328:Insulin; D036341:Intercellular Signaling Peptides and Proteins; D037181:Lectins, C-Type; C464940:MGL2 protein, mouse; C413576:Retnla protein, mouse; D005947:Glucose
keywords: adipose tissue macrophage; alternatively activated macrophage; glucose metabolism