title: Effects of Aging on the Coagulation Fibrinolytic System in Outpatients of the Cardiovascular Department.
abstract: BACKGROUND
  Although clinical trials demonstrate that the elderly with atrial fibrillation have risks of thrombosis and bleeding, the relationship between aging and coagulation fibrinolytic system in "real-world" cardiology outpatients is uncertain.
  
  
  RESULTS
  We retrospectively evaluated 773 patients (mean age: 58 years; 52% men; Asian ethnicity). To thoroughly investigate markers of coagulation and fibrinolysis, we simultaneously measured levels of D-dimer, prothrombin-fragment1+2 (F1+2), plasmin-α2 plasmin inhibitor complex (PIC), and thrombomodulin (TM). There were correlations between aging and levels of F1+2, D-dimer, PIC, and TM (R=0.61, 0.57, 0.49, and 0.30, respectively). We compared 3 age groups, which were defined as the Y group (<64 years), M group (65-74 years), and the O group (>75 years). Levels of markers were higher in older individuals (D-dimer: 1.0±0.8 vs. 0.8±0.8 vs. 0.6±0.4 μg/ml, F1+2: 281.8±151.3 vs. 224.6±107.1 vs. 155.5±90.0 pmol/L, PIC: 0.9±0.3 vs. 0.8±0.3 vs. 0.6±0.5 μg/ml, and TM: 2.9±0.8 vs. 2.7±0.7 vs. 2.5±0.7FU/ml). We performed logistic regression analysis to determine F1+2 and PIC levels. Multivariate analysis revealed that aging was the most important determinant of high F1+2 and PIC levels.
  
  
  CONCLUSIONS
  Hypercoagulable states develop with advancing age in "real-world" cardiology outpatients. (Circ J 2016; 80: 2133-2140).
authors: Division of Cardiology, Department of Medicine, Showa University School of Medicine.
authors: Akinori
authors: A
authors: Ochi
authors: Taro
authors: T
authors: Adachi
authors: Koichiro
authors: K
authors: Inokuchi
authors: Ko
authors: K
authors: Ogawa
authors: Yuya
authors: Y
authors: Nakamura
authors: Yuta
authors: Y
authors: Chiba
authors: Shiro
authors: S
authors: Kawasaki
authors: Yoshimi
authors: Y
authors: Onishi
authors: Yoshimasa
authors: Y
authors: Onuma
authors: Yumi
authors: Y
authors: Munetsugu
authors: Hiroyuki
authors: H
authors: Ito
authors: Tatsuya
authors: T
authors: Onuki
authors: Yoshino
authors: Y
authors: Minoura
authors: Norikazu
authors: N
authors: Watanabe
authors: Mitsuharu
authors: M
authors: Kawamura
authors: Taku
authors: T
authors: Asano
authors: Youichi
authors: Y
authors: Kobayashi
mesh_terms: D000328:Adult; D000368:Aged; D000375:Aging / Q000097:blood*; D005260:Female; D005342:Fibrinolysis; D006801:Humans; D008297:Male; D008875:Middle Aged; D010045:Outpatients; D012189:Retrospective Studies; D019851:Thrombophilia / Q000097:blood*