title: Renoprotective effects of ursolic acid on ischemia/reperfusion‑induced acute kidney injury through oxidative stress, inflammation and the inhibition of STAT3 and NF‑κB activities.
abstract: Ursolic acid, a pentacyclic triterpene compound with low toxicity and easy availability, has a variety of biological activities, including antitumor, antioxidant, antihepatitis, anti‑inflammatory and antibacterial effects. The present study aimed to investigate the renoprotective effects of ursolic acid on ischemia/reperfusion‑induced acute kidney injury (I/R‑IAKI) in rats associated with its antioxidant and anti‑inflammatory effects, as well as interference with the signal transducer and activator of transcription (STAT)3/nuclear factor (NF)‑κB signaling pathway. The present study demonstrated that pre‑treatment with ursolic acid significantly increased renal functioning and attenuated increases of serum angiotensin II levels in rats subjected to I/R‑IAKI. In addition, I/R‑IAKI‑induced inflammation and oxidative stress were significantly reduced by pre‑treatment with ursolic acid. Furthermore, ursolic acid significantly suppressed the upregulation of STAT3, NF‑κB and caspase‑3 activities in rats following I/R‑IAKI. These results indicated that ursolic acid may be a potential drug for reducing I/R‑IAKI through suppression of inflammation and oxidative stress damage, as well as modulation of STAT3 and NF‑κB activities.
authors: Department of Nephrology, Wuhan General Hospital of Guangzhou Military Area, Wuhan, Hubei 430030, P.R. China.
authors: Jun
authors: J
authors: Peng
authors: Department of Nephrology, Wuhan General Hospital of Guangzhou Military Area, Wuhan, Hubei 430030, P.R. China.
authors: Xingfeng
authors: X
authors: Ren
authors: Department of Nephrology, Wuhan General Hospital of Guangzhou Military Area, Wuhan, Hubei 430030, P.R. China.
authors: Tianbiao
authors: T
authors: Lan
authors: Department of Nephrology, Wuhan General Hospital of Guangzhou Military Area, Wuhan, Hubei 430030, P.R. China.
authors: Yan
authors: Y
authors: Chen
authors: Department of Nephrology, Wuhan General Hospital of Guangzhou Military Area, Wuhan, Hubei 430030, P.R. China.
authors: Ziyun
authors: Z
authors: Shao
authors: Department of Nephrology, Wuhan General Hospital of Guangzhou Military Area, Wuhan, Hubei 430030, P.R. China.
authors: Cheng
authors: C
authors: Yang
mesh_terms: D058186:Acute Kidney Injury / Q000150:complications / Q000188:drug therapy* / Q000276:immunology / Q000473:pathology; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000627:therapeutic use*; D000975:Antioxidants / Q000737:chemistry / Q000627:therapeutic use; D007249:Inflammation / Q000150:complications / Q000188:drug therapy* / Q000276:immunology / Q000473:pathology; D007668:Kidney / Q000187:drug effects* / Q000276:immunology / Q000473:pathology; D008297:Male; D016328:NF-kappa B / Q000276:immunology*; D018384:Oxidative Stress / Q000187:drug effects; D031347:Prunella / Q000737:chemistry; D051381:Rats; D017207:Rats, Sprague-Dawley; D015427:Reperfusion Injury / Q000150:complications / Q000188:drug therapy* / Q000276:immunology / Q000473:pathology; D050796:STAT3 Transcription Factor / Q000276:immunology*; D014315:Triterpenes / Q000737:chemistry / Q000627:therapeutic use*; D000097245:Ursolic Acid
chemical_list: D000893:Anti-Inflammatory Agents; D000975:Antioxidants; D016328:NF-kappa B; D050796:STAT3 Transcription Factor; D014315:Triterpenes; D000097245:Ursolic Acid