title: Ruthenium(II)-Catalyzed C-H Activation of Imidamides and Divergent Couplings with Diazo Compounds: Substrate-Controlled Synthesis of Indoles and 3H-Indoles.
abstract: Indoles are an important structural motif that is commonly found in biologically active molecules. In this work, conditions for divergent couplings between imidamides and acceptor-acceptor diazo compounds were developed that afforded NH indoles and 3H-indoles under ruthenium catalysis. The coupling of α-diazoketoesters afforded NH indoles by cleavage of the C(N2 )-C(acyl) bond whereas α-diazomalonates gave 3H-indoles by C-N bond cleavage. This reaction constitutes the first intermolecular coupling of diazo substrates with arenes by ruthenium-catalyzed C-H activation.
authors: Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, 116023, China.|University of Chinese Academy of Sciences, Beijing, 100049, China.
authors: Yunyun
authors: Y
authors: Li
authors: Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, 116023, China.
authors: Zisong
authors: Z
authors: Qi
authors: Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, 116023, China.
authors: He
authors: H
authors: Wang
authors: Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, 116023, China.|University of Chinese Academy of Sciences, Beijing, 100049, China.
authors: Xifa
authors: X
authors: Yang
authors: Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, 116023, China. xwli@dicp.ac.cn.
authors: Xingwei
authors: X
authors: Li
keywords: C−H activation; diazo compounds; indoles; ruthenium; transition-metal catalysis