title: Comparative genomic analysis of Brazilian Leptospira kirschneri serogroup Pomona serovar Mozdok.
abstract: Leptospira kirschneri is one of the pathogenic species of the Leptospira genus. Human and animal infection from L. kirschneri gained further attention over the last few decades. Here we present the isolation and characterisation of Brazilian L. kirschneri serogroup Pomona serovar Mozdok strain M36/05 and the comparative genomic analysis with Brazilian human strain 61H. The M36/05 strain caused pulmonary hemorrhagic lesions in the hamster model, showing high virulence. The studied genomes presented high symmetrical identity and the in silico multilocus sequence typing analysis resulted in a new allelic profile (ST101) that so far has only been associated with the Brazilian L. kirschneri serogroup Pomona serovar Mozdok strains. Considering the environmental conditions and high genomic similarity observed between strains, we suggest the existence of a Brazilian L. kirschneri serogroup Pomona serovar Mozdok lineage that could represent a high public health risk; further studies are necessary to confirm the lineage significance and distribution.
authors: Universidade de São Paulo, Faculdade de Medicina Veterinária e Zootecnia, Laboratório de Epidemiologia Molecular e Resistência a Antimicrobianos, São Paulo, SP, Brasil.
authors: Luisa Z
authors: LZ
authors: Moreno
authors: Universidade Federal de Pelotas, Centro de Desenvolvimento Tecnológico, Pelotas, RS, Brasil.
authors: Frederico S
authors: FS
authors: Kremer
authors: Universidade Federal Fluminense, Departamento de Microbiologia e Parasitologia, Laboratório de Bacteriologia Veterinária, Niterói, RJ, Brasil.
authors: Fabiana
authors: F
authors: Miraglia
authors: Universidade Federal Fluminense, Departamento de Microbiologia e Parasitologia, Laboratório de Bacteriologia Veterinária, Niterói, RJ, Brasil.
authors: Ana P
authors: AP
authors: Loureiro
authors: Universidade Federal de Pelotas, Centro de Desenvolvimento Tecnológico, Pelotas, RS, Brasil.
authors: Marcus R
authors: MR
authors: Eslabao
authors: Universidade Federal de Pelotas, Centro de Desenvolvimento Tecnológico, Pelotas, RS, Brasil.
authors: Odir A
authors: OA
authors: Dellagostin
authors: Universidade Federal Fluminense, Departamento de Microbiologia e Parasitologia, Laboratório de Bacteriologia Veterinária, Niterói, RJ, Brasil.
authors: Walter
authors: W
authors: Lilenbaum
authors: Universidade de São Paulo, Faculdade de Medicina Veterinária e Zootecnia, Laboratório de Epidemiologia Molecular e Resistência a Antimicrobianos, São Paulo, SP, Brasil.
authors: Andrea M
authors: AM
authors: Moreno
mesh_terms: D000818:Animals; D006224:Cricetinae; D004269:DNA, Bacterial / Q000235:genetics*; D016680:Genome, Bacterial / Q000235:genetics*; D007919:Leptospira / Q000235:genetics* / Q000472:pathogenicity; D058885:Multilocus Sequence Typing; D051381:Rats; D065288:Serogroup; D012703:Serotyping
chemical_list: D004269:DNA, Bacterial