title: Atrial Fibrillation is Strongly Associated With the Neutrophil to Lymphocyte Ratio in Acute Ischemic Stroke Patients: A Retrospective Study.
abstract: BACKGROUND
  No study has investigated the relationship between hospital-admission neutrophil and lymphocyte ratio (NLR) and various stroke risk factors. We sought to determine which stroke risk factor could be the most appropriate predictor of NLR in acute ischemic stroke.
  
  
  METHODS
  We collected data on various stroke risk factors and National Institutes of Health Stroke Scale (NIHSS) score in 1,053 acute ischemic stroke patients. The regression analysis was adjusted for confounding factors such as stroke risk factors.
  
  
  RESULTS
  There was a trend of increased NLR with a rise in alcohol consumption, the prevalence of hypertension, cardioembolism (CE) etiology, the NIHSS scores in men and the prevalence of atrial fibrillation, other heart diseases, CE and small vessel occlusion etiology and the NIHSS scores in women. Multiple linear regression analyses, adjusted for confounding factors, showed that the atrial fibrillation and NIHSS scores in men and atrial fibrillation, diabetes mellitus as well as NIHSS scores in women had a significant positive association with NLR. However, a negative association was showed for body mass index (BMI).
  
  
  CONCLUSIONS
  We confirmed that the atrial fibrillation can be a predictor of high NLR in acute stroke patients, and diabetes mellitus as well as low BMI could be a predictor of high NLR in female acute ischemic stroke patients.
authors: Department of Cardiology and Neurology, College of Korean Medicine, Kyung Hee University, Seoul, Korea.
authors: Kyungdong
authors: K
authors: Min
authors: Department of Cardiology and Neurology, College of Korean Medicine, Kyung Hee University, Seoul, Korea.
authors: Seungwon
authors: S
authors: Kwon
authors: Department of Cardiology and Neurology, College of Korean Medicine, Kyung Hee University, Seoul, Korea.
authors: Seung-Yeon
authors: SY
authors: Cho
authors: Department of Korean Medicine Cardiology and Neurology, Graduate School, Kyung Hee University, Seoul, Korea.
authors: Woo Jun
authors: WJ
authors: Choi
authors: Department of Cardiology and Neurology, College of Korean Medicine, Kyung Hee University, Seoul, Korea.
authors: Seong-Uk
authors: SU
authors: Park
authors: Department of Cardiology and Neurology, College of Korean Medicine, Kyung Hee University, Seoul, Korea.
authors: Woo-Sang
authors: WS
authors: Jung
authors: Department of Cardiology and Neurology, College of Korean Medicine, Kyung Hee University, Seoul, Korea.
authors: Sang-Kwan
authors: SK
authors: Moon
authors: Department of Cardiology and Neurology, College of Korean Medicine, Kyung Hee University, Seoul, Korea.
authors: Jung-Mi
authors: JM
authors: Park
authors: Department of Cardiology and Neurology, College of Korean Medicine, Kyung Hee University, Seoul, Korea.
authors: Chang-Nam
authors: CN
authors: Ko
authors: Department of Cardiology and Neurology, College of Korean Medicine, Kyung Hee University, Seoul, Korea.
authors: Ki-Ho
authors: KH
authors: Cho
mesh_terms: D000368:Aged; D000428:Alcohol Drinking / Q000009:adverse effects; D001281:Atrial Fibrillation / Q000150:complications* / Q000473:pathology; D015415:Biomarkers; D015992:Body Mass Index; D002545:Brain Ischemia / Q000150:complications* / Q000473:pathology; D003920:Diabetes Mellitus; D004617:Embolism / Q000150:complications; D005260:Female; D006801:Humans; D006973:Hypertension / Q000150:complications; D007958:Leukocyte Count; D008214:Lymphocytes / Q000166:cytology*; D008297:Male; D009504:Neutrophils / Q000166:cytology*; D012189:Retrospective Studies; D012307:Risk Factors; D020521:Stroke / Q000150:complications* / Q000473:pathology
chemical_list: D015415:Biomarkers
keywords: acute ischemic stroke; atrial fibrillation; diabetes mellitus; neutrophil to lymphocyte ratio; stroke prognosis