title: Brain damage resembling acute necrotizing encephalopathy as a specific manifestation of haemophagocytic lymphohistiocytosis - induced by hypersensitivity.
abstract: BACKGROUND
  Both haemophagocytic lymphohistiocytosis and acute necrotizing encephalopathy are life-threatening condition. It presents major diagnostic difficulties, since it may have a diversity in clinical picture and with many conditions leading to the same clinical presentation. So it is key important to understand the disorders.
  
  
  METHODS
  We report a pediatric case of haemophagocytic lymphohistiocytosis with specific presentation which predominantly featured as acute necrotizing encephalopathy of childhood. We discuss the diagnosis and differential diagnosis, and speculate the etiology of haemophagocytic lymphohistiocytosis is due to hypersensitivity.
  
  
  CONCLUSIONS
  Haemophagocytic lymphohistiocytosis and brain damage in this case may be induced by hypersensitivity, which have good clinical outcome if diagnosed and treated early.
authors: First Affiliated Hospital of Jinan University, No.601 Huangpu Avenue West, Guangzhou, 510630, China.|Shenzhen Children's Hospital, 7019, Yitian Road, Shenzhen, 518036, Futian District, China.
authors: Dongling
authors: D
authors: Dai
authors: Shenzhen Children's Hospital, 7019, Yitian Road, Shenzhen, 518036, Futian District, China. fwen621@126.com.
authors: Feiqiu
authors: F
authors: Wen
authors: Shenzhen Children's Hospital, 7019, Yitian Road, Shenzhen, 518036, Futian District, China.
authors: Sixi
authors: S
authors: Liu
authors: Shenzhen Children's Hospital, 7019, Yitian Road, Shenzhen, 518036, Futian District, China.
authors: Shaoming
authors: S
authors: Zhou
mesh_terms: D001927:Brain Diseases / Q000175:diagnosis* / Q000209:etiology*; D003937:Diagnosis, Differential; D006801:Humans; D006967:Hypersensitivity / Q000150:complications* / Q000175:diagnosis*; D007223:Infant; D004684:Leukoencephalitis, Acute Hemorrhagic / Q000175:diagnosis; D051359:Lymphohistiocytosis, Hemophagocytic / Q000175:diagnosis* / Q000209:etiology*; D008279:Magnetic Resonance Imaging; D008297:Male
keywords: Acute necrotizing encephalopathy of childhood; Brain damage; Haemophagocytic lymphohistiocytosis; Hypersensitivity