title: Research on Gene-Environment Interplay in the Era of "Big Data".
abstract: Successful identification of genetic risk factors in genomewide association studies typically has depended on meta-analyses combining data from large numbers of studies involving tens or hundreds of thousands of participants. This poses a challenge for research on Gene × Environment interaction (G × E) effects, where characterization of environmental exposures is quite limited in most studies and often varies idiosyncratically between studies. Yet the importance of environmental exposures in the etiology of many disorders-and especially alcohol, tobacco, and drug use disorders-is undeniable. We discuss the potential for "big-data" approaches (e.g., aggregating data from state databases) to generate consistent measures of neighborhood environment across multiple studies, requiring only information about residential address (or ideally residential history) to make progress in G × E analyses. Big-data approaches may also help address limits to the generalizability of existing research literature, such as those that arise because of the limited numbers of severely alcohol-dependent mothers represented in prospective research studies.
authors: Midwest Alcoholism Research Center.|Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri aheath@wustl.edu.
authors: Andrew C
authors: AC
authors: Heath
authors: Midwest Alcoholism Research Center.|Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri.
authors: Christina N
authors: CN
authors: Lessov-Schlaggar
authors: Midwest Alcoholism Research Center.|Department of Medicine, Washington University School of Medicine, St. Louis, Missouri.
authors: Min
authors: M
authors: Lian
authors: Midwest Alcoholism Research Center.|Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri.
authors: Ruth
authors: R
authors: Miller
authors: Midwest Alcoholism Research Center.|George Warren Brown School of Social Work, Washington University in St. Louis, St. Louis, Missouri.
authors: Alexis E
authors: AE
authors: Duncan
authors: Midwest Alcoholism Research Center.|Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri.
authors: Pamela A F
authors: PA
authors: Madden
mesh_terms: D003627:Data Interpretation, Statistical; D004781:Environmental Exposure / Q000009:adverse effects; D059647:Gene-Environment Interaction; D006801:Humans; D011446:Prospective Studies; D019966:Substance-Related Disorders / Q000453:epidemiology* / Q000235:genetics*