title: Properties of modified carboxymethyl cellulose and its use as bioactive compound.
abstract: The present study deals with synthesizing novel cellulose derivative, from modifying the carboxymethyl cellulose with amino phenylpropanoic acid (CMC-APP). The synthesized CMC-APP was evaluated as biological and anti-cancer active compound. The molecular structures of this active compound were built using the HyperChem program 7.5, together with conventional analysis (nitrogen content, FT-IR, and non-isothermal TGA analysis). Optimizing the CMC/APPA ratio was carried out as preliminary assessment step, via undetected antimicrobial activity measurement. The TEM study showed that, the synthesized cellulose CMC-APP derivative in the nano-scale particle size (range from 12.5 to 89.3nm). Among all the tested microorganisms and MCF-7 breast cancer cells, the synthesized nano-cellulose derivative is possible used as safety medicine for microbial infections and cancers. The minimal inhibitory concentration (MIC) for Gram-positive bacteria, and gram-negative bacteria are 48.82μg/mL and 97μg/mL, respectively. While, the unicellular fungi and filamentous fungi are 12.2μg/mL and 97.65μg/mL, respectively. The cytotoxic index (IC50) for MCF-7 breast cancers is 50μg/mL. Moreover, the computational study of ADMET (absorption, distribution, metabolism, elimination and toxic) properties, of the molecules showed that, this investigated nano-compound is good oral bioavailability.
authors: Cellulose & Paper Dept., National Research Centre, El-Buhouth St., Dokki 12622, Egypt. Electronic address: altaf_basta2004@yahoo.com.
authors: Altaf H
authors: AH
authors: Basta
authors: Cellulose & Paper Dept., National Research Centre, El-Buhouth St., Dokki 12622, Egypt.
authors: Houssni
authors: H
authors: El-Saied
authors: Cancer Institute, Cairo University, Egypt.
authors: Mervat M
authors: MM
authors: El-Deftar
authors: Cellulose & Paper Dept., National Research Centre, El-Buhouth St., Dokki 12622, Egypt.
authors: Ahmed A
authors: AA
authors: El-Henawy
authors: Chemistry Department,Faculty of Science, Al-Azhar University, Cairo, Egypt; Botany and Microbiology Department, Faculty of Science, Al-Azhar University, Cairo, Egypt.
authors: Hussein H
authors: HH
authors: El-Sheikh
authors: Chemistry Department,Faculty of Science, Al-Azhar University, Cairo, Egypt; Botany and Microbiology Department, Faculty of Science, Al-Azhar University, Cairo, Egypt.
authors: Essam H
authors: EH
authors: Abdel-Shakour
authors: Cellulose & Paper Dept., National Research Centre, El-Buhouth St., Dokki 12622, Egypt.
authors: Mohamed S
authors: MS
authors: Hasanin
mesh_terms: D000586:Amination; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D000935:Antifungal Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D001424:Bacterial Infections / Q000188:drug therapy; D002266:Carboxymethylcellulose Sodium / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D005658:Fungi / Q000187:drug effects; D006801:Humans; D061986:MCF-7 Cells; D008958:Models, Molecular; D009181:Mycoses / Q000188:drug therapy; D010666:Phenylpropionates / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D000970:Antineoplastic Agents; D010666:Phenylpropionates; C035253:3-phenylpropionic acid; D002266:Carboxymethylcellulose Sodium
keywords: Anti-cancer active cellulose derivative; Antimicrobial active cellulose derivative; CMC; Nanomedicine; Novel nano-cellulose derivatives