title: 5-HT1A receptor agonists, xaliproden and tandospirone, inhibit the increase in the number of cutaneous mast cells involved in the exacerbation of mechanical allodynia in oxaliplatin-treated mice.
abstract: Oxaliplatin causes peripheral neuropathy as a major dose-limiting side effect, and the control of this neuropathy is difficult. This study was designed to investigate whether prophylactic repetitive administration of 5-HT1A receptor agonists inhibits oxaliplatin-induced mechanical allodynia in mice. Repetitive administration of 5-HT1A receptor agonists (xaliproden and tandospirone) inhibited mechanical allodynia induced by a single intraperitoneal injection of oxaliplatin. These agonists also inhibited oxaliplatin-induced mast cell migration, which is involved in the induction of mechanical allodynia. These results suggest that the prophylactic repetitive administration of 5-HT1A receptor agonists attenuates oxaliplatin-induced mechanical allodynia by inhibiting the cutaneous mast cell migration.
authors: Department of Applied Pharmacology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama 930-0194, Japan. Electronic address: andoht@pha.u-toyama.ac.jp.
authors: Tsugunobu
authors: T
authors: Andoh
authors: Department of Applied Pharmacology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama 930-0194, Japan.
authors: Ayumi
authors: A
authors: Sakamoto
authors: Research Administration Division, Tokyo Medical and Dental University, Tokyo 113-8510, Japan.
authors: Yasushi
authors: Y
authors: Kuraishi
mesh_terms: D000818:Animals; D002465:Cell Movement / Q000187:drug effects*; D006930:Hyperalgesia / Q000139:chemically induced / Q000276:immunology* / Q000517:prevention & control*; D054833:Isoindoles / Q000494:pharmacology*; D008297:Male; D008407:Mast Cells / Q000166:cytology / Q000187:drug effects*; D051379:Mice; D009281:Naphthalenes / Q000494:pharmacology*; D009944:Organoplatinum Compounds; D000077150:Oxaliplatin; D010879:Piperazines / Q000494:pharmacology*; D011725:Pyridines / Q000494:pharmacology*; D011743:Pyrimidines / Q000494:pharmacology*; D058825:Serotonin 5-HT1 Receptor Agonists / Q000494:pharmacology*; D012867:Skin / Q000276:immunology
chemical_list: D054833:Isoindoles; D009281:Naphthalenes; D009944:Organoplatinum Compounds; D010879:Piperazines; D011725:Pyridines; D011743:Pyrimidines; D058825:Serotonin 5-HT1 Receptor Agonists; D000077150:Oxaliplatin; C055267:tandospirone; C462299:xaliproden
keywords: Mast cells; Tandospirone; Xaliproden