title: The role of active brown adipose tissue (aBAT) in lipid metabolism in healthy Chinese adults.
abstract: BACKGROUND
  The prevalence of dyslipidemia in China was increased over the last several years. Studies have shown that the activity of aBAT is related to the lipid metabolism. In this study, we analyzed blood lipid level in tumor-free healthy Chinese adults in order to determine the role of aBAT in lipid metabolism.
  
  
  METHODS
  We retrospectively analyzed the factors that affect the blood lipid level in 717 tumor-free healthy adults who received blood lipid measurement and PET/CT scan by multivariate regression analysis. We also determined the role of aBAT on lipid profile by case-control study.
  
  
  RESULTS
  (1) Our results showed that 411 (57.3 %) subjects had dyslipidemia. The prevalence of the subjects with hypercholesteremia, hypertriglyceridemia, low high-density lipoprotein cholesterol and high low-density lipoprotein cholesterol was 9.5 %, 44.4 %, 30.8 % and 1.4 %, respectively. Multivariate logistic regression analysis with dyslipidemia as the dependent variable showed that body mass index (BMI) and smoking are independent risk factors for dyslipidemia (OR > 1, P < 0.05), while the presence of aBAT is the independent protective factor for dyslipidemia (OR < 1, P < 0.05). (2) The incidence of aBAT was 1.81 %. Subjects with aBAT had significantly lower serum triglyceride and higher serum high-density lipoprotein cholesterol than the subjects without aBAT. The serum total cholesterol and low-density lipoprotein cholesterol were not significantly different between the subjects with aBAT and those without aBAT.
  
  
  CONCLUSIONS
  Dyslipidemia is caused by multiple factors and the presence of aBAT is a protective factor for dyslipidemia in healthy Chinese adults.
authors: Department of Nuclear Medicine, the Third Affiliated Hospital of Soochow University, Changzhou, 213003, China.
authors: Xiaoliang
authors: X
authors: Shao
authors: Department of Nuclear Medicine, the Third Affiliated Hospital of Soochow University, Changzhou, 213003, China.
authors: Wei
authors: W
authors: Yang
authors: Department of Nuclear Medicine, the Third Affiliated Hospital of Soochow University, Changzhou, 213003, China.
authors: Xiaonan
authors: X
authors: Shao
authors: Department of Nuclear Medicine, the Third Affiliated Hospital of Soochow University, Changzhou, 213003, China.
authors: Chun
authors: C
authors: Qiu
authors: Department of Nuclear Medicine, the Third Affiliated Hospital of Soochow University, Changzhou, 213003, China.
authors: Xiaosong
authors: X
authors: Wang
authors: Department of Nuclear Medicine, the Third Affiliated Hospital of Soochow University, Changzhou, 213003, China. yuetao-w@163.com.
authors: Yuetao
authors: Y
authors: Wang
mesh_terms: D002001:Adipose Tissue, Brown / Q000000981:diagnostic imaging / Q000378:metabolism* / Q000503:physiopathology; D000328:Adult; D044466:Asian People; D050171:Dyslipidemias / Q000453:epidemiology / Q000503:physiopathology*; D005260:Female; D006801:Humans; D050356:Lipid Metabolism; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D012189:Retrospective Studies; D012307:Risk Factors
keywords: 18F-Fluorodeoxyglucose; Chinese; Dyslipidemia; Positron emission tomography; aBAT