title: Effect of thyroid peroxidase antibodies on thyroid-stimulating hormone reference limits in a primarily Latina population.
abstract: The aim of the paper is to determine the prevalence of thyroid peroxidase antibodies (TPOAb) and assess its effect on the thyroid-stimulating hormone (TSH) reference range during pregnancy in a primarily Latina population. Serum samples were collected from healthy pregnant women and non-pregnant controls. TSH reference ranges were calculated when TPOAb-positive patients were either included or excluded. A total of 134 pregnant women and 107 non-pregnant controls were recruited. Positive TPOAb titres were found in 23 (17.2%) of the 134 pregnant women, and in 14 (13.1%) of the 107 non-pregnant controls. When the TPOAb-positive women were included in the TSH analysis, the upper reference limit using two different methods was consistently higher: 0-2.2 fold in the non-pregnant women, 2.01-2.78 fold in the first trimester, 3.18-4.7 fold in the second and 1.05-1.42 fold in the third. The lower TSH reference limit was not affected by the inclusion of TPOAb-positive subjects. In conclusion, inclusion of TPOAb-positive patients results in higher upper reference limits during pregnancy.
authors: Department of Obstetrics and Gynecology, Los Angeles County-University of Southern California Medical Center , Los Angeles, CA.
authors: Richard H
authors: RH
authors: Lee
authors: Department of Medicine, Boston University Medical Center , Boston, MA.
authors: Carole A
authors: CA
authors: Spencer
authors: Department of Obstetrics and Gynecology, Los Angeles County-University of Southern California Medical Center, Los Angeles, CA; Department of Medicine, Boston University Medical Center, Boston, MA.
authors: Martin N
authors: MN
authors: Montoro
authors: Department of Obstetrics and Gynecology, Los Angeles County-University of Southern California Medical Center , Los Angeles, CA.
authors: Paola
authors: P
authors: Aghajanian
authors: Department of Obstetrics and Gynecology, Los Angeles County-University of Southern California Medical Center , Los Angeles, CA.
authors: T Murphy
authors: TM
authors: Goodwin
authors: Department of Obstetrics and Gynecology, Los Angeles County-University of Southern California Medical Center , Los Angeles, CA.
authors: Erin A
authors: EA
authors: Miller
authors: Department of Obstetrics and Gynecology, Los Angeles County-University of Southern California Medical Center , Los Angeles, CA.
authors: Ivana
authors: I
authors: Petrovic
authors: Department of Medicine, Los Angeles County-University of Southern California Medical Center , Los Angeles, CA , USA.
authors: Lewis E
authors: LE
authors: Braverman
authors: Department of Obstetrics and Gynecology, Los Angeles County-University of Southern California Medical Center, Los Angeles, CA; Department of Medicine, Boston University Medical Center, Boston, MA.
authors: Jorge H
authors: JH
authors: Mestman
keywords: Latina; pregnancy; reference; thyroid