title: Performance on the Cogstate Brief Battery Is Related to Amyloid Levels and Hippocampal Volume in Very Mild Dementia.
abstract: In a group of older adults with very mild dementia, we aimed to characterize the nature and magnitude of cognitive decline as measured by the Cogstate Brief Battery, in relation to Aβ levels and hippocampal volume. Participants were characterized according to their status on the Clinical Dementia Rating (CDR) scale. A total of 308 individuals who were CDR 0 and had low cerebral Aβ levels (Aβ-), 32 individuals who were Aβ- and CDR 0.5, and 43 individuals who were Aβ+ and CDR 0.5 were included in this study. Participants completed the CogState brief battery at baseline, and at 18-, 36-, 54- and 72-month follow-up. Linear mixed model analyses indicated that relative to the Aβ- CDR 0 group, the Aβ+ CDR 0.5 group showed increased rates of memory decline and hippocampal volume loss. However, compared to the Aβ- CDR 0 group, the Aβ- CDR 0.5 group showed no changes in cognitive function or hippocampal volume over 72 months. The results of this study confirm that in individuals with very mild dementia, who also have biomarker confirmation of Aβ+, changes in cognitive function manifest primarily as deterioration in memory processing, and this is associated with hippocampal volume loss. Conversely, the absence of any cognitive decline or loss in hippocampal volume in individuals with very mild dementia but who are Aβ- suggests that some other non-AD disease process may underlie any static impairment in cognitive function.
authors: The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, 155 Oak Street, Parkville, VIC, 3052, Australia. yen.lim@florey.edu.au.
authors: Yen Ying
authors: YY
authors: Lim
authors: The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, 155 Oak Street, Parkville, VIC, 3052, Australia.|Department of Nuclear Medicine and Centre for PET, Austin Health, Heidelberg, VIC, Australia.|Department of Medicine, Austin Health, The University of Melbourne, Heidelberg, VIC, Australia.
authors: Victor L
authors: VL
authors: Villemagne
authors: Centre of Excellence for Alzheimer's Disease Research and Care, Edith Cowan University, Joondalup, WA, Australia.|Sir James McCusker Alzheimer's Disease Research Unit, Hollywood Private Hospital, Perth, WA, Australia.|Co-operative Research Centre for Mental Health, Carlton, Australia.
authors: Simon M
authors: SM
authors: Laws
authors: Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.
authors: Robert H
authors: RH
authors: Pietrzak
authors: Academic Unit for Psychiatry of Old Age, St. Vincent's Health, The University of Melbourne, Kew, VIC, Australia.|National Ageing Research Institute, Parkville, VIC, Australia.
authors: David
authors: D
authors: Ames
authors: The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, 155 Oak Street, Parkville, VIC, 3052, Australia.
authors: Christopher
authors: C
authors: Fowler
authors: Centre of Excellence for Alzheimer's Disease Research and Care, Edith Cowan University, Joondalup, WA, Australia.
authors: Stephanie
authors: S
authors: Rainey-Smith
authors: Department of Neurology, Alpert Medical School of Brown University, Providence, RI, USA.
authors: Peter J
authors: PJ
authors: Snyder
authors: Commonwealth Scientific Industrial Research Organization (CSIRO) Preventative Health National Research Flagship, Australian e-Health Research Centre-BiaMedIA, Brisbane, QLD, Australia.
authors: Pierrick
authors: P
authors: Bourgeat
authors: Centre of Excellence for Alzheimer's Disease Research and Care, Edith Cowan University, Joondalup, WA, Australia.
authors: Ralph N
authors: RN
authors: Martins
authors: Commonwealth Scientific Industrial Research Organization (CSIRO) Preventative Health National Research Flagship, Australian e-Health Research Centre-BiaMedIA, Brisbane, QLD, Australia.
authors: Olivier
authors: O
authors: Salvado
authors: Department of Nuclear Medicine and Centre for PET, Austin Health, Heidelberg, VIC, Australia.|Department of Medicine, Austin Health, The University of Melbourne, Heidelberg, VIC, Australia.
authors: Christopher C
authors: CC
authors: Rowe
authors: The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, 155 Oak Street, Parkville, VIC, 3052, Australia.
authors: Colin L
authors: CL
authors: Masters
authors: The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, 155 Oak Street, Parkville, VIC, 3052, Australia.|CogState Ltd., Melbourne, VIC, Australia.
authors: Paul
authors: P
authors: Maruff
mesh_terms: D000368:Aged; D016229:Amyloid beta-Peptides / Q000378:metabolism*; D015415:Biomarkers / Q000378:metabolism; D003071:Cognition; D060825:Cognitive Dysfunction / Q000175:diagnosis* / Q000000981:diagnostic imaging; D005260:Female; D006624:Hippocampus / Q000000981:diagnostic imaging* / Q000378:metabolism; D006801:Humans; D008297:Male; D008568:Memory; D008875:Middle Aged; D009483:Neuropsychological Tests
chemical_list: D016229:Amyloid beta-Peptides; D015415:Biomarkers
keywords: Alzheimer’s disease; Amyloid; Hippocampal volume; Memory; Mild dementia