title: Deep Brain Stimulation in Huntington's Disease-Preliminary Evidence on Pathophysiology, Efficacy and Safety.
abstract: Huntington's disease (HD) is one of the most disabling degenerative movement disorders, as it not only affects the motor system but also leads to cognitive disabilities and psychiatric symptoms. Deep brain stimulation (DBS) of the pallidum is a promising symptomatic treatment targeting the core motor symptom: chorea. This article gives an overview of preliminary evidence on pathophysiology, safety and efficacy of DBS in HD.
authors: Department of Neurology, Medical Faculty, Heinrich-Heine University Düsseldorf, Moorenstrasse 5, Düsseldorf 40225, Germany. lars.wojtecki@med.uni-duesseldorf.de.|Institute of Clinical Neuroscience & Medical Psychology, Medical Faculty, Heinrich-Heine University Düsseldorf, Moorenstrasse 5, Düsseldorf 40225, Germany. lars.wojtecki@med.uni-duesseldorf.de.
authors: Lars
authors: L
authors: Wojtecki
authors: Department of Neurology, Medical Faculty, Heinrich-Heine University Düsseldorf, Moorenstrasse 5, Düsseldorf 40225, Germany. groiss@uni-duesseldorf.de.|Institute of Clinical Neuroscience & Medical Psychology, Medical Faculty, Heinrich-Heine University Düsseldorf, Moorenstrasse 5, Düsseldorf 40225, Germany. groiss@uni-duesseldorf.de.
authors: Stefan Jun
authors: SJ
authors: Groiss
authors: Department of Neurology, Medical Faculty, Heinrich-Heine University Düsseldorf, Moorenstrasse 5, Düsseldorf 40225, Germany. christian-hartmann@uni-duesseldorf.de.|Institute of Clinical Neuroscience & Medical Psychology, Medical Faculty, Heinrich-Heine University Düsseldorf, Moorenstrasse 5, Düsseldorf 40225, Germany. christian-hartmann@uni-duesseldorf.de.
authors: Christian Johannes
authors: CJ
authors: Hartmann
authors: Department of Neurology, Medical Faculty, Heinrich-Heine University Düsseldorf, Moorenstrasse 5, Düsseldorf 40225, Germany. saskia.elben@med.uni-duesseldorf.de.|Institute of Clinical Neuroscience & Medical Psychology, Medical Faculty, Heinrich-Heine University Düsseldorf, Moorenstrasse 5, Düsseldorf 40225, Germany. saskia.elben@med.uni-duesseldorf.de.
authors: Saskia
authors: S
authors: Elben
authors: Institute of Clinical Neuroscience & Medical Psychology, Medical Faculty, Heinrich-Heine University Düsseldorf, Moorenstrasse 5, Düsseldorf 40225, Germany.
authors: Sonja
authors: S
authors: Omlor
authors: Department of Neurology, Medical Faculty, Heinrich-Heine University Düsseldorf, Moorenstrasse 5, Düsseldorf 40225, Germany. Sonja.Omlor@uni-duesseldorf.de.|Institute of Clinical Neuroscience & Medical Psychology, Medical Faculty, Heinrich-Heine University Düsseldorf, Moorenstrasse 5, Düsseldorf 40225, Germany. Sonja.Omlor@uni-duesseldorf.de.
authors: Alfons
authors: A
authors: Schnitzler
authors: Department of Functional Neurosurgery and Stereotaxy, Medical Faculty, Heinrich-Heine University Düsseldorf, Moorenstrasse 5, Düsseldorf 40225, Germany. jan.vesper@med.uni-duesseldorf.de.
authors: Jan
authors: J
authors: Vesper
keywords: DBS; Huntington; chorea; deep brain stimulation; globus pallidus; recordings; safety pathophysiology