title: Relationship between Chemical Structure and Antimicrobial Activities of Isothiocyanates from Cruciferous Vegetables against Oral Pathogens.
abstract: We evaluated the potentials of 10 isothiocyanates (ITCs) from cruciferous vegetables and radish root hydrolysate for inhibiting the growth of oral pathogens, with an emphasis on assessing any structure-function relationship. Structural differences in ITCs impacted their antimicrobial activities against oral pathogens differently. The indolyl ITC (indol-3-carbinol) was the most potent inhibitor of the growth of oral pathogens, followed by aromatic ITCs (benzyl ITC (BITC) and phenylethyl ITC (PEITC)) and aliphatic ITCs (erucin, iberin, and sulforaphene). Sulforaphene, which is similar in structure, but has one double bond, showed higher antimicrobial activity than sulforaphane. Erucin, which has a thiol group, showed higher antimicrobial activity than sulforaphane, which has a sulfinyl group. BITC and iberin with a short chain exhibited higher antimicrobial potential than PEITC and sulforaphane with a longer chain, respectively. ITCs have strong antimicrobial activities and may be useful in the prevention and management of dental caries.
authors: Department of Food Bioengineering, Jeju National University, Jeju 63243, Republic of Korea.|Jeju Wellbeing Vegetables RIS System, Jeju National University, Jeju 63243, Republic of Korea.
authors: Mi-Ok
authors: MO
authors: Ko
authors: Jeju Wellbeing Vegetables RIS System, Jeju National University, Jeju 63243, Republic of Korea.|Department of Biotechnology, Yonsei University, Seoul 03722, Republic of Korea.
authors: Mi-Bo
authors: MB
authors: Kim
authors: Department of Food Bioengineering, Jeju National University, Jeju 63243, Republic of Korea.|Jeju Wellbeing Vegetables RIS System, Jeju National University, Jeju 63243, Republic of Korea.
authors: Sang-Bin
authors: SB
authors: Lim
mesh_terms: D000890:Anti-Infective Agents / Q000737:chemistry* / Q000494:pharmacology*; D001419:Bacteria / Q000145:classification / Q000187:drug effects; D019607:Brassicaceae / Q000737:chemistry*; D006801:Humans; D017879:Isothiocyanates / Q000737:chemistry* / Q000494:pharmacology*; D009055:Mouth / Q000382:microbiology; D009059:Mouth Diseases / Q000382:microbiology; D010936:Plant Extracts / Q000737:chemistry* / Q000494:pharmacology*; D014675:Vegetables / Q000737:chemistry*
chemical_list: D000890:Anti-Infective Agents; D017879:Isothiocyanates; D010936:Plant Extracts
keywords: Cruciferous vegetables; antimicrobial activity; isothiocyanates; oral pathogens; radish root hydrolysate