title: Tissue engineering and regenerative medicine in musculoskeletal oncology.
abstract: Currently used surgical techniques to reconstruct tissue defects after resection of musculoskeletal tumours are associated with high complication rates. This drives a strong demand for innovative therapeutic concepts that are able to improve the clinical outcomes of patients suffering from bone and soft tissue tumours. Tissue engineering and regenerative medicine (TE&RM) provides a technology platform based on biochemical, molecular, cellular and biomaterials modules to selectively direct tissue healing processes for improved defect regeneration. At the same time, precautionary measures have to be taken when these instruments are used in cancer patients to prevent any promotion of tumour growth or metastatic spread. On the other hand, several innovative TE&RM tools are being developed such as multi-functionalized biomaterials, drug-delivering nanomaterials or genetically engineered stem cells that per se have the potential to mediate anti-cancer effects, act synergistically with currently used chemotherapeutics and/or radiotherapy regimens and reduce their side effects. Recently, scientists became conscious that TE&RM strategies may not only be utilized to advance contemporary tissue reconstruction techniques but also to develop personalized diagnostic tools and clinically relevant disease models for cancer patients. Eventually, prospective randomized clinical trials combined with comparative outcome analyses are a conditio sine qua non to shape the benefits of personalized regenerative therapies for the standardized management of patients with musculoskeletal tumours.
authors: Regenerative Medicine, Institute of Health and Biomedical Innovation, Queensland University of Technology, 60 Musk Avenue, Kelvin Grove, Brisbane, QLD, 4049, Australia. holzapfel@orthopaedic-oncology.net.|Department of Orthopaedic Surgery, University of Wuerzburg, Koenig-Ludwig-Haus, Brettreichstr. 11, 97072, Wuerzburg, Germany. holzapfel@orthopaedic-oncology.net.
authors: Boris Michael
authors: BM
authors: Holzapfel
authors: Regenerative Medicine, Institute of Health and Biomedical Innovation, Queensland University of Technology, 60 Musk Avenue, Kelvin Grove, Brisbane, QLD, 4049, Australia.|Department of Orthopaedics, University Regensburg, Asklepios Clinic Bad Abbach, Kaiser-Karl V.-Allee 3, 93077, Bad Abbach, Germany.|Department of Pediatric Surgery, Dr. von Hauner Children's Hospital, Ludwig-Maximilians-University Munich, Lindwurmstraße 4, 80337, Munich, Germany.
authors: Ferdinand
authors: F
authors: Wagner
authors: Regenerative Medicine, Institute of Health and Biomedical Innovation, Queensland University of Technology, 60 Musk Avenue, Kelvin Grove, Brisbane, QLD, 4049, Australia.
authors: Laure Christine
authors: LC
authors: Martine
authors: Department of Orthopaedic Surgery, University of Wuerzburg, Koenig-Ludwig-Haus, Brettreichstr. 11, 97072, Wuerzburg, Germany.
authors: Stephan
authors: S
authors: Reppenhagen
authors: Department of Orthopaedic Surgery, University of Wuerzburg, Koenig-Ludwig-Haus, Brettreichstr. 11, 97072, Wuerzburg, Germany.
authors: Maximilian
authors: M
authors: Rudert
authors: Department of Trauma and Reconstructive Surgery, Center for Musculoskeletal Surgery, Charite University Medicine Berlin, Campus Virchow, Augustenburger Pl. 1, 13353, Berlin, Germany.
authors: Michael
authors: M
authors: Schuetz
authors: School of Medicine and Public Health, University of Newcastle, Newcastle, NSW, Australia.
authors: Jim
authors: J
authors: Denham
authors: Department of Plastic Surgery and Hand Surgery, University Clinic Rechts der Isar, Technical University Munich, Ismaningerstr. 22, 81675, Munich, Germany.|School of Chemical and Biomedical Engineering, Nanyang Technological University, 62 Nanyang Drive, Singapore, 637459, Singapore.
authors: Jan-Thorsten
authors: JT
authors: Schantz
authors: Regenerative Medicine, Institute of Health and Biomedical Innovation, Queensland University of Technology, 60 Musk Avenue, Kelvin Grove, Brisbane, QLD, 4049, Australia. dietmar.hutmacher@qut.edu.au.|George W Woodruff School of Mechanical Engineering, Georgia Institute of Technology, 801 Ferst Drive Northwest, Atlanta, GA, 30332, USA. dietmar.hutmacher@qut.edu.au.|Institute for Advanced Study, Technical University Munich, Lichtenbergstraße 2a, 85748, Garching, Munich, Germany. dietmar.hutmacher@qut.edu.au.
authors: Dietmar Werner
authors: DW
authors: Hutmacher
mesh_terms: D000818:Animals; D001859:Bone Neoplasms / Q000175:diagnosis / Q000601:surgery / Q000628:therapy*; D006801:Humans; D023421:Models, Animal; D019042:Muscle Neoplasms / Q000175:diagnosis / Q000601:surgery / Q000628:therapy*; D011182:Postoperative Care; D057285:Precision Medicine; D044968:Regenerative Medicine / Q000379:methods; D023822:Tissue Engineering / Q000379:methods
keywords: Bone tumours; Defect reconstruction; Disease models; Musculoskeletal oncology; Sarcoma; Tissue engineering