title: The effects of platelet apheresis on blood saving and coagulation in bilateral total hip replacement: A prospective study on 60 patients.
abstract: BACKGROUND
  Preoperative platelet rich plasma (PRP) harvest has been used in cardiopulmonary surgery for more than 10 years. There is no previous study dealing with PRP in bilateral total hip replacement. This study was to investigate the effects of PRP on blood saving and blood coagulation function in patients with bilateral total hip replacement.
  
  
  METHODS
  A prospective, randomized, clinical trial was conducted. Sixty patients were enrolled, including 30 patients undergoing PRP in the PRP group and 30 controls. The surgery time, total transfusion volume, blood loss, allogenic blood transfusion, autologous blood transfusion, urine volume, drainage volume, some blood parameters (including Fibrinogen, D-dimer, Prothrombin time, international normalizedratio, activated partial thromboplastin time, Platelet, Haemoglobin B), thrombelastogram (TEG) and blood-gas parameters were studied in the perioperative stage. The measurement data were analyzed statistically.
  
  
  RESULTS
  There was no statistical difference between the two groups in baseline characteristics, surgery time, total transfusion volume, blood loss, autologous blood transfusion, etc. Allogenic blood transfusion in the PRP group was less than the control group with statistical difference (p = 0.024). Fibrinogen in the PRP group was higher than the control group (p = 0.008). Among the TEG indicators, activated clotting time and coagulation time K in the PRP group were less than the control group. Clotting rate and maximum amplitude in the PRP group were higher. The blood-gas parameters presented no statistical difference.
  
  
  CONCLUSIONS
  The results suggested that PRP probably played a positive role in blood coagulation function as well as blood saving in patients with bilateral total hip replacement.
authors: Department of Anesthesiology, Beijing Anzhen Hospital, Capital Medical University, China; Department of Anesthesiology, Beijing Jishuitan Hospital, China.
authors: Zhijun
authors: Z
authors: Qu
authors: Department of Anesthesiology, Beijing Jishuitan Hospital, China.
authors: Geng
authors: G
authors: Wang
authors: Department of Anesthesiology, Beijing Jishuitan Hospital, China.
authors: Chengshi
authors: C
authors: Xu
authors: Department of Anesthesiology, Beijing Jishuitan Hospital, China.
authors: Dazhi
authors: D
authors: Zhang
authors: Department of Anesthesiology, Beijing Jishuitan Hospital, China.
authors: Xiangdong
authors: X
authors: Qu
authors: Department of Anesthesiology, Beijing Jishuitan Hospital, China.
authors: Haibin
authors: H
authors: Zhou
authors: Department of Anesthesiology, Beijing Anzhen Hospital, Capital Medical University, China. Electronic address: majun6512@163.com.
authors: Jun
authors: J
authors: Ma
mesh_terms: D000328:Adult; D000368:Aged; D019644:Arthroplasty, Replacement, Hip; D001777:Blood Coagulation; D001780:Blood Coagulation Tests; D016063:Blood Loss, Surgical / Q000517:prevention & control*; D001804:Blood Transfusion, Autologous / Q000379:methods*; D005260:Female; D005338:Fibrin Fibrinogen Degradation Products / Q000032:analysis; D005340:Fibrinogen / Q000032:analysis; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D008297:Male; D008875:Middle Aged; D017713:Platelet Transfusion / Q000379:methods*; D010983:Plateletpheresis / Q000379:methods*; D011300:Preoperative Care / Q000379:methods*; D011446:Prospective Studies; D016037:Single-Blind Method
chemical_list: D005338:Fibrin Fibrinogen Degradation Products; D006454:Hemoglobins; C036309:fibrin fragment D; D005340:Fibrinogen; C020622:hemoglobin B
keywords: Blood coagulation function; Fibrinogen; Preoperative platelet rich plasma harvest; Thrombelastogram; Total hip arthroplasty