title: Cough in idiopathic pulmonary fibrosis.
abstract: Many patients with idiopathic pulmonary fibrosis (IPF) complain of chronic refractory cough. Chronic cough is a distressing and disabling symptom with a major impact on quality of life. During recent years, progress has been made in gaining insight into the pathogenesis of cough in IPF, which is most probably "multifactorial" and influenced by mechanical, biochemical and neurosensory changes, with an important role for comorbidities as well. Clinical trials of cough treatment in IPF are emerging, and cough is increasingly included as a secondary end-point in trials assessing new compounds for IPF. It is important that such studies include adequate end-points to assess cough both objectively and subjectively. This article summarises the latest insights into chronic cough in IPF. It describes the different theories regarding the pathophysiology of cough, reviews the different methods to assess cough and deals with recent and future developments in the treatment of cough in IPF.
authors: Dept of Respiratory Medicine, Erasmus MC, University Medical Center, Rotterdam, The Netherlands.
authors: Mirjam J G
authors: MJ
authors: van Manen
authors: Division of Asthma, Allergy and Lung Biology, King's College London, London, UK.
authors: Surinder S
authors: SS
authors: Birring
authors: Dept of Clinical and Experimental Medicine, Section of Respiratory Disease, University of Catania, Catania, Italy.
authors: Carlo
authors: C
authors: Vancheri
authors: Dept of Respiratory Medicine, Louis Pradel Hospital, Hospices Civils de Lyon, Lyon 1 University, Lyon, France.
authors: Vincent
authors: V
authors: Cottin
authors: Interstitial Lung Disease Unit, Royal Brompton Hospital, London, UK.
authors: Elisabetta A
authors: EA
authors: Renzoni
authors: Interstitial Lung Disease Unit, Royal Brompton Hospital, London, UK National Heart and Lung Institute, Imperial College London, London, UK.
authors: Anne-Marie
authors: AM
authors: Russell
authors: Dept of Respiratory Medicine, Erasmus MC, University Medical Center, Rotterdam, The Netherlands m.wijsenbeek-lourens@erasmusmc.nl.
authors: Marlies S
authors: MS
authors: Wijsenbeek
mesh_terms: D000818:Animals; D000996:Antitussive Agents / Q000627:therapeutic use; D002908:Chronic Disease; D015897:Comorbidity; D003371:Cough / Q000188:drug therapy / Q000209:etiology* / Q000503:physiopathology; D006801:Humans; D054990:Idiopathic Pulmonary Fibrosis / Q000150:complications* / Q000188:drug therapy / Q000503:physiopathology; D011379:Prognosis; D011788:Quality of Life; D012307:Risk Factors
chemical_list: D000996:Antitussive Agents