title: Integrative systems medicine approaches to identify molecular targets in lymphoid malignancies.
abstract: Although survival rates for lymphoproliferative disorders are steadily increasing both in the US and in Europe, there is need for optimizing front-line therapies and developing more effective salvage strategies. Recent advances in molecular genetics have highlighted the biological diversity of lymphoproliferative disorders. In particular, integrative approaches including whole genome sequencing, whole exome sequencing, and transcriptome or RNA sequencing have been instrumental to the identification of molecular targets for treatment. Herein, we will discuss how genomic, epigenomic and proteomic approaches in lymphoproliferative disorders have supported the discovery of molecular lesions and their therapeutic targeting in the clinic.
authors: Laboratory of Translational Research, IRCCS "Arcispedale S. Maria Nuova", Reggio Emilia, Italy.
authors: Raffaele
authors: R
authors: Frazzi
authors: European Institute for Systems Biology and Medicine (EISBM), Paris, France.
authors: Charles
authors: C
authors: Auffray
authors: Division of Hematology, IRCCS "Arcispedale S. Maria Nuova", Reggio Emilia, Italy.
authors: Angela
authors: A
authors: Ferrari
authors: Division of Translational Medicine, Sidra Medical and Research Centre, Doha, Qatar.
authors: Perla
authors: P
authors: Filippini
authors: John van Geest Cancer Research Centre, College of Science and Technology, Nottingham Trent University, Clifton Campus, Nottingham, NG11 8NS, UK. sergio.rutella@ntu.ac.uk.
authors: Sergio
authors: 0000-0003-1970-7375
authors: S
authors: Rutella
authors: Clinical Governance and International Research Activities, Fondazione Policlinico Gemelli, Rome, Italy.|Division of Thoracic Surgery, Università Cattolica del Sacro Cuore, Rome, Italy.|European Association of Systems Medicine, Aachen, Germany.
authors: Alfredo
authors: A
authors: Cesario
mesh_terms: D000818:Animals; D059014:High-Throughput Nucleotide Sequencing; D006801:Humans; D008223:Lymphoma / Q000628:therapy*; D058990:Molecular Targeted Therapy; D009154:Mutation / Q000235:genetics; D011379:Prognosis; D040901:Proteomics
keywords: High throughput RNA sequencing; Lymphoproliferative disorder; Massively-Parallel sequencing; Systems medicine