title: IFN-stimulated gene expression is independent of the IFNL4 genotype in chronic HIV-1 infection.
abstract: This study aimed to evaluate the association between the IFNL4 rs368234815 (ΔG/TT) dinucleotide polymorphism and the IFN response during chronic HIV-1 infection. We carried out genotyping analysis and measured the expression of IFN-stimulated genes (ISGs) (myxovirus resistance protein A [MxA], ISG15, ISG56, apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like [APOBEC] 3F and APOBEC3G) on peripheral blood mononuclear cells collected from naïve and HAART-treated HIV-1-infected patients. There were no statistically significant differences in endogenous ISGs mRNA levels among HIV-1-positive patients bearing different IFNL4 genotypes, suggesting that ISG expression is independent of the IFNL4 genotype in HIV-1 infection.
authors: Laboratory of Virology, Department of Molecular Medicine, Istituto Pasteur Italia-Cenci Bolognetti Fondazione, Sapienza University of Rome, Viale di Porta Tiburtina n° 28, 00185, Rome, Italy.
authors: Katia
authors: K
authors: Monteleone
authors: Laboratory of Virology, Department of Molecular Medicine, Istituto Pasteur Italia-Cenci Bolognetti Fondazione, Sapienza University of Rome, Viale di Porta Tiburtina n° 28, 00185, Rome, Italy.
authors: Giuseppe Corano
authors: GC
authors: Scheri
authors: Laboratory of Virology, Department of Molecular Medicine, Istituto Pasteur Italia-Cenci Bolognetti Fondazione, Sapienza University of Rome, Viale di Porta Tiburtina n° 28, 00185, Rome, Italy.
authors: Maura
authors: M
authors: Statzu
authors: Laboratory of Virology, Department of Molecular Medicine, Istituto Pasteur Italia-Cenci Bolognetti Fondazione, Sapienza University of Rome, Viale di Porta Tiburtina n° 28, 00185, Rome, Italy.
authors: Carla
authors: C
authors: Selvaggi
authors: Laboratory of Virology, Department of Molecular Medicine, Istituto Pasteur Italia-Cenci Bolognetti Fondazione, Sapienza University of Rome, Viale di Porta Tiburtina n° 28, 00185, Rome, Italy.
authors: Francesca
authors: F
authors: Falasca
authors: Department of Public Health and Infectious Diseases, Sapienza University of Rome, Rome, Italy.
authors: Noemi
authors: N
authors: Giustini
authors: Department of Clinical Medicine, Sapienza University of Rome, Rome, Italy.
authors: Ivano
authors: I
authors: Mezzaroma
authors: Laboratory of Virology, Department of Molecular Medicine, Istituto Pasteur Italia-Cenci Bolognetti Fondazione, Sapienza University of Rome, Viale di Porta Tiburtina n° 28, 00185, Rome, Italy.
authors: Ombretta
authors: O
authors: Turriziani
authors: Department of Public Health and Infectious Diseases, Sapienza University of Rome, Rome, Italy.
authors: Gabriella
authors: G
authors: d'Ettorre
authors: Laboratory of Virology, Department of Molecular Medicine, Istituto Pasteur Italia-Cenci Bolognetti Fondazione, Sapienza University of Rome, Viale di Porta Tiburtina n° 28, 00185, Rome, Italy.
authors: Guido
authors: G
authors: Antonelli
authors: Laboratory of Virology, Department of Molecular Medicine, Istituto Pasteur Italia-Cenci Bolognetti Fondazione, Sapienza University of Rome, Viale di Porta Tiburtina n° 28, 00185, Rome, Italy. carolina.scagnolari@uniroma1.it.
authors: Carolina
authors: http://orcid.org/0000-0003-1044-1478
authors: C
authors: Scagnolari
mesh_terms: D000328:Adult; D005260:Female; D020869:Gene Expression Profiling; D005838:Genotype; D060005:Genotyping Techniques; D015658:HIV Infections / Q000276:immunology*; D006801:Humans; D007155:Immunologic Factors / Q000096:biosynthesis*; D007378:Interleukins / Q000235:genetics*; D007963:Leukocytes, Mononuclear / Q000276:immunology; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D012333:RNA, Messenger / Q000032:analysis; D000095022:Interferon Lambda
chemical_list: D007155:Immunologic Factors; D007378:Interleukins; D012333:RNA, Messenger; C579163:IFNL4 protein, human; D000095022:Interferon Lambda
keywords: HIV-1; IFN; IFNL4; ISGs; SNP