title: Are there optimal numbers of oocytes, spermatozoa and embryos in assisted reproduction?
abstract: The aim of this overview is to discuss the current information about the search for the optimum yield of gametes in assisted reproduction, as one of the major pillars of IVF success. The first topic is focused on the number of male gametes and the possible impact of some genetic traits on these parameters. The number of spermatozoa did not seem to be crucial when there is no severe male factor of infertility. Genetic testing prior to using those sperm cells is very important. Different methods were applied in order to elect the "best" spermatozoa according to specific indications. The next problem discussed is the importance of the number of oocytes collected. Several studies have agreed that "15 oocytes is the perfect number," as the number of mature oocytes is more important. However, if elective single embryo transfer is performed, the optimal number of oocytes will enable a proper embryo selection. The third problem discussed concerns fertility preservation. Many educational programs promote and encourage procreation at maternal ages between 20-35 years, since assisted reproduction is unable to fully overcome the effects of female aging and fertility loss after that age. It is also strongly recommended to ensure a reasonable number of cryopreserved mature oocytes, preferably in younger ages (<35), for which an average of two stimulation cycles are likely required. For embryo cryopreservation, the "freeze all" strategy suggests the vitrification of good embryos, therefore quality is prior to number and patient recruitment for this strategy should be performed cautiously.
authors: SAGBAL Dr. Shterev, IVF Unit, Sofia, Bulgaria.
authors: Tanya
authors: T
authors: Milachich
authors: SAGBAL Dr. Shterev, IVF Unit, Sofia, Bulgaria.
authors: Atanas
authors: A
authors: Shterev
mesh_terms: D004622:Embryo, Mammalian; D005260:Female; D059247:Fertility Preservation; D006801:Humans; D008297:Male; D009865:Oocytes / Q000166:cytology / Q000502:physiology; D027724:Reproductive Techniques, Assisted; D013094:Spermatozoa / Q000166:cytology / Q000502:physiology
keywords: Assisted reproduction; Fertility preservation; Mature oocyte; Oocyte number; Spermatozoa count