title: The effects of photobiomodulation therapy on Staphylococcus aureus infected surgical wounds in diabetic rats. A microbiological, histopathological, and biomechanical study.
abstract: OBJECTIVE
  To evaluate the effects of photobiomodulation therapy (PBMT) at 685 nm on diabetic wound healing in rats suffering from bacterial infection induced by Staphylococcus aureus (S. aureus).
  
  
  METHODS
  Thirty streptozotocin-induced diabetic rats were allocated into two groups: control and PBMT. A 4-cm full-thickness linear-incision was made on the dorsal midline and was contaminated with S. aureus. The wounds in the PBMT group were irradiated daily for 5 consecutive days, starting 3 days after the induction and always in the mornings.
  
  
  RESULTS
  The result revealed that PBMT resulted in a significant decrease in S. aureus CFU in the PBMT group in comparison to the control group (P<0.05). The length of wounds, in the 2nd and 3rd weeks, in the PBMT group were significantly shorter compared to the control group (P<0.05). PBMT caused a significant increase in the histological parameters in comparison to the control group (P<0.05). Moreover, PBMT significantly increased the breaking strength of the surgical scars produced in the skin of the PBMT group when compared to the control group (P<0.05).
  
  
  CONCLUSIONS
  Photobiomodulation therapy may be useful in the management of wound infection through a significant bacterial growth inhibition and an acceleration of wound healing process.
authors: Full professor, Molecular Biology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran. Design and supervised all phases of the study.
authors: Reza
authors: R
authors: Ranjbar
authors: PhD, Young Researchers and Elites Club, Science and Research Branch, Islamic Azad University, Tehran, Iran. Conception and design of the study; acquisition, analysis and interpretation of data; statistical analysis; manuscript writing.
authors: Mohammad Ashrafzadeh
authors: MA
authors: Takhtfooladi
mesh_terms: D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000139:chemically induced / Q000150:complications*; D004195:Disease Models, Animal; D028022:Low-Level Light Therapy / Q000379:methods*; D008297:Male; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D013203:Staphylococcal Infections / Q000382:microbiology / Q000532:radiotherapy*; D013211:Staphylococcus aureus / Q000528:radiation effects; D013530:Surgical Wound Infection / Q000382:microbiology / Q000532:radiotherapy*; D014945:Wound Healing / Q000528:radiation effects*