title: Changes in Sympathetic Innervation of Rat Caudal Artery in Experimental Myocardial Infarction. Effect of Semax Peptide.
abstract: Activation of the sympathetic nervous system aggravates the course of myocardial infarction. Semax peptide moderated the degree of this activation and prevented the increase in the density of sympathetic endings in rat caudal artery in 28 days after ischemia or ischemia/reperfusion. The peptide reduced the density of α-adrenoreceptors in the caudal artery of rats with myocardial infarction. Semax produced no effect on β-adrenoreceptors in both experimental models. The experiments on isolated segments of the caudal artery revealed reduced vascular responsiveness to electrical stimulation and norepinephrine infusion in rats treated with Semax after ischemia/reperfusion injury.
authors: Department of Physiology and General Pathology, Fundamental Medicine Faculty, M. V. Lomonosov Moscow State University, Moscow, Russia. ann.gorbachewa@yandex.ru.
authors: A M
authors: AM
authors: Gorbacheva
authors: Department of Physiology and General Pathology, Fundamental Medicine Faculty, M. V. Lomonosov Moscow State University, Moscow, Russia.
authors: A B
authors: AB
authors: Berdalin
authors: Department of Physiology and General Pathology, Fundamental Medicine Faculty, M. V. Lomonosov Moscow State University, Moscow, Russia.
authors: A N
authors: AN
authors: Stulova
authors: Department of Physiology and General Pathology, Fundamental Medicine Faculty, M. V. Lomonosov Moscow State University, Moscow, Russia.
authors: A D
authors: AD
authors: Nikogosova
authors: Department of Physiology and General Pathology, Fundamental Medicine Faculty, M. V. Lomonosov Moscow State University, Moscow, Russia.
authors: M D
authors: MD
authors: Lin
authors: Department of Physiology and General Pathology, Fundamental Medicine Faculty, M. V. Lomonosov Moscow State University, Moscow, Russia.
authors: S V
authors: SV
authors: Buravkov
authors: Department of Physiology and General Pathology, Fundamental Medicine Faculty, M. V. Lomonosov Moscow State University, Moscow, Russia.
authors: S A
authors: SA
authors: Gavrilova
authors: Department of Physiology and General Pathology, Fundamental Medicine Faculty, M. V. Lomonosov Moscow State University, Moscow, Russia.
authors: V B
authors: VB
authors: Koshelev
mesh_terms: D000324:Adrenocorticotropic Hormone / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use; D000818:Animals; D004558:Electric Stimulation; D008297:Male; D009203:Myocardial Infarction / Q000188:drug therapy* / Q000378:metabolism*; D018696:Neuroprotective Agents / Q000494:pharmacology / Q000627:therapeutic use; D009638:Norepinephrine / Q000494:pharmacology / Q000627:therapeutic use; D010446:Peptide Fragments / Q000494:pharmacology* / Q000627:therapeutic use*; D051381:Rats; D011943:Receptors, Adrenergic, beta / Q000378:metabolism; D013564:Sympathetic Nervous System / Q000187:drug effects* / Q000378:metabolism*
chemical_list: D018696:Neuroprotective Agents; D010446:Peptide Fragments; D011943:Receptors, Adrenergic, beta; C048487:ACTH (4-7), Pro-Gly-Pro-; D000324:Adrenocorticotropic Hormone; D009638:Norepinephrine
keywords: Semax; autonomic nervous system; cardioprotection; myocardial infarction; rat