title: Treatment of Schistosomiasis in a Patient Allergic to Praziquantel: A Desensitization and Treatment Protocol.
abstract: Praziquantel is the mainstay of treatment of Schistosomiasis, which affects at least 262 million people worldwide. It is also used in the treatment of other trematode as well as cestode infections, with few safe and effective alternatives. It is generally well tolerated and allergic reactions are rare. In this report, we present a case of schistosomiasis with a history of a hypersensitivity reaction to praziquantel. Skin-prick and intradermal testing were performed, followed by treatment through rapid desensitization. This protocol may be of value to those patients requiring praziquantel treatment with a history of IgE-mediated allergy to the drug.
authors: Hospital for Tropical Diseases, London, United Kingdom.
authors: Trupti A
authors: TA
authors: Patel
authors: Royal National Throat, Nose and Ear Hospital, University College London Hospital, London, United Kingdom. joanna.lukawska@uclh.nhs.uk.
authors: Joanna
authors: J
authors: Lukawska
authors: Enys Road Surgery, Eastbourne, United Kingdom.
authors: Jennifer
authors: J
authors: Rowe
authors: Hospital for Tropical Diseases, London, United Kingdom.
authors: Robin L
authors: RL
authors: Bailey
mesh_terms: D000328:Adult; D003888:Desensitization, Immunologic; D004342:Drug Hypersensitivity / Q000175:diagnosis* / Q000188:drug therapy; D005260:Female; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood; D011223:Praziquantel / Q000276:immunology / Q000627:therapeutic use*; D012552:Schistosomiasis / Q000188:drug therapy* / Q000276:immunology; D006113:United Kingdom
chemical_list: D007073:Immunoglobulin E; D011223:Praziquantel