title: The activation of p38MAPK and JNK pathways in bovine herpesvirus 1 infected MDBK cells.
abstract: We have shown previously that BHV-1 infection activates Erk1/2 signaling. Here, we show that BHV-1 provoked an early-stage transient and late-stage sustained activation of JNK, p38MAPK and c-Jun signaling in MDBK cells. C-Jun phosphorylation was dependent on JNK. These early events were partially due to the viral entry process. Unexpectedly, reactive oxygen species were not involved in the later activation phase. Interestingly, only activated JNK facilitated the viral multiplication identified through both chemical inhibitor and siRNA. Collectively, this study provides insight into our understanding of early stages of BHV-1 infection.
authors: College of Veterinary Medicine and Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University, 48 Wenhui East Road, Yangzhou, 225009, China.
authors: Liqian
authors: L
authors: Zhu
authors: College of Veterinary Medicine and Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University, 48 Wenhui East Road, Yangzhou, 225009, China.
authors: Chen
authors: C
authors: Yuan
authors: College of Veterinary Medicine and Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University, 48 Wenhui East Road, Yangzhou, 225009, China.
authors: Liyuan
authors: L
authors: Huang
authors: College of Veterinary Medicine and Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University, 48 Wenhui East Road, Yangzhou, 225009, China.|The Test Center of Yangzhou University, 48 Wenhui East Road, Yangzhou, 225009, China.
authors: Xiuyan
authors: X
authors: Ding
authors: College of Veterinary Medicine and Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University, 48 Wenhui East Road, Yangzhou, 225009, China.
authors: Jianye
authors: J
authors: Wang
authors: College of Veterinary Medicine and Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University, 48 Wenhui East Road, Yangzhou, 225009, China.
authors: Dong
authors: D
authors: Zhang
authors: College of Veterinary Medicine and Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University, 48 Wenhui East Road, Yangzhou, 225009, China. yzgqzhu@yzu.edu.cn.
authors: Guoqiang
authors: G
authors: Zhu
mesh_terms: D000818:Animals; D015153:Blotting, Western; D002417:Cattle; D002460:Cell Line; D004847:Epithelial Cells / Q000166:cytology; D006566:Herpesviridae Infections / Q000378:metabolism*; D007242:Herpesvirus 1, Bovine / Q000502:physiology; D007668:Kidney / Q000166:cytology; D020935:MAP Kinase Signaling System / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology*; D014779:Virus Replication / Q000502:physiology; D048051:p38 Mitogen-Activated Protein Kinases / Q000502:physiology*
chemical_list: D048051:p38 Mitogen-Activated Protein Kinases