title: Onconeural Antibodies in Acute Psychiatric Inpatient Care.
abstract: Paraneoplastic neurological disorders associated with onconeural antibodies often appear with neuropsychiatric symptoms. To study the prevalence of onconeural antibodies in patients admitted to acute psychiatric inpatient care, the serum of 585 such patients was tested for antibodies targeting MOG, GLRA1B, DPPX, GRM1, GRM5, DNER, Yo, ZIC4, GAD67, amphiphysin, CV2, Hu, Ri, Ma2, and recoverin. Only one sample was positive (antirecoverin IgG). The present findings suggest that serum onconeural antibody positivity is rare among patients acutely admitted for inpatient psychiatric care. The clinical implications of this finding are discussed.
authors: From the Dept. of Neuroscience, Norwegian University of Science and Technology, Trondheim, Norway (SGS, MS, AV, DK, SKR); the Dept. of Psychiatry, St. Olav's University Hospital, Trondheim, Norway (SGS, MS, AV, SKR); the Institute for Experimental Immunology, Euroimmun AG, Lübeck, Germany (WS, BT, KB); and the Dept. of Neurology, Rigshospitalet, Copenhagen, Denmark (DK).
authors: Sverre Georg
authors: SG
authors: Sæther
authors: From the Dept. of Neuroscience, Norwegian University of Science and Technology, Trondheim, Norway (SGS, MS, AV, DK, SKR); the Dept. of Psychiatry, St. Olav's University Hospital, Trondheim, Norway (SGS, MS, AV, SKR); the Institute for Experimental Immunology, Euroimmun AG, Lübeck, Germany (WS, BT, KB); and the Dept. of Neurology, Rigshospitalet, Copenhagen, Denmark (DK).
authors: Morten
authors: M
authors: Schou
authors: From the Dept. of Neuroscience, Norwegian University of Science and Technology, Trondheim, Norway (SGS, MS, AV, DK, SKR); the Dept. of Psychiatry, St. Olav's University Hospital, Trondheim, Norway (SGS, MS, AV, SKR); the Institute for Experimental Immunology, Euroimmun AG, Lübeck, Germany (WS, BT, KB); and the Dept. of Neurology, Rigshospitalet, Copenhagen, Denmark (DK).
authors: Winfried
authors: W
authors: Stoecker
authors: From the Dept. of Neuroscience, Norwegian University of Science and Technology, Trondheim, Norway (SGS, MS, AV, DK, SKR); the Dept. of Psychiatry, St. Olav's University Hospital, Trondheim, Norway (SGS, MS, AV, SKR); the Institute for Experimental Immunology, Euroimmun AG, Lübeck, Germany (WS, BT, KB); and the Dept. of Neurology, Rigshospitalet, Copenhagen, Denmark (DK).
authors: Bianca
authors: B
authors: Teegen
authors: From the Dept. of Neuroscience, Norwegian University of Science and Technology, Trondheim, Norway (SGS, MS, AV, DK, SKR); the Dept. of Psychiatry, St. Olav's University Hospital, Trondheim, Norway (SGS, MS, AV, SKR); the Institute for Experimental Immunology, Euroimmun AG, Lübeck, Germany (WS, BT, KB); and the Dept. of Neurology, Rigshospitalet, Copenhagen, Denmark (DK).
authors: Kathrin
authors: K
authors: Borowski
authors: From the Dept. of Neuroscience, Norwegian University of Science and Technology, Trondheim, Norway (SGS, MS, AV, DK, SKR); the Dept. of Psychiatry, St. Olav's University Hospital, Trondheim, Norway (SGS, MS, AV, SKR); the Institute for Experimental Immunology, Euroimmun AG, Lübeck, Germany (WS, BT, KB); and the Dept. of Neurology, Rigshospitalet, Copenhagen, Denmark (DK).
authors: Arne
authors: A
authors: Vaaler
authors: From the Dept. of Neuroscience, Norwegian University of Science and Technology, Trondheim, Norway (SGS, MS, AV, DK, SKR); the Dept. of Psychiatry, St. Olav's University Hospital, Trondheim, Norway (SGS, MS, AV, SKR); the Institute for Experimental Immunology, Euroimmun AG, Lübeck, Germany (WS, BT, KB); and the Dept. of Neurology, Rigshospitalet, Copenhagen, Denmark (DK).
authors: Daniel
authors: D
authors: Kondziella
authors: From the Dept. of Neuroscience, Norwegian University of Science and Technology, Trondheim, Norway (SGS, MS, AV, DK, SKR); the Dept. of Psychiatry, St. Olav's University Hospital, Trondheim, Norway (SGS, MS, AV, SKR); the Institute for Experimental Immunology, Euroimmun AG, Lübeck, Germany (WS, BT, KB); and the Dept. of Neurology, Rigshospitalet, Copenhagen, Denmark (DK).
authors: Solveig Klæbo
authors: SK
authors: Reitan
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000912:Antibodies, Neoplasm / Q000097:blood*; D001774:Blood Chemical Analysis; D003430:Cross-Sectional Studies; D005260:Female; D006778:Hospitals, Psychiatric; D006785:Hospitals, University; D006801:Humans; D007297:Inpatients; D008297:Male; D001523:Mental Disorders / Q000453:epidemiology / Q000209:etiology / Q000276:immunology* / Q000628:therapy; D008875:Middle Aged; D020361:Paraneoplastic Syndromes, Nervous System / Q000453:epidemiology / Q000276:immunology / Q000523:psychology / Q000628:therapy; D015995:Prevalence; D040081:Protein Array Analysis; D012189:Retrospective Studies; D055815:Young Adult
chemical_list: D000912:Antibodies, Neoplasm
keywords: Neuroimmunology; Organic Mental Disorders