title: Comparative investigation on the pharmacokinetics of geniposide in type 2 diabetic and normal rats after oral administration of Fructus Gradeniae extract.
abstract: Fructus Gradeniae, the fruit of Gardenia jasminoides Ellis, was used alone or in combination with other herb medicines in the treatment of type 2 diabetes mellitus in China for a long time. In present investigation, the HPLC method for the determination of geniposide in rat plasma was developed and validated, and the pharmacokinetics of geniposide in type 2 diabetic rats after oral administration of Fructus Gradeniae extract or pure was studied. The results showed that the pharmacokinetic profile (especially the area under the plasma concentration-time curve, AUC) of geniposide in type 2 diabetic rats after orally administered with Fructus Gradeniae extract or pure geniposide was remarkably different from that in normal rats. The results indicated that the increased AUC of geniposide in type 2 diabetic rats did not result from the effects of other components contained in Fructus Gradeniae. It could be speculated that the increased AUC of geniposide might result from the pathological state of type 2 diabetes mellitus which resulted in the pharmacokinetic alterations of geniposide.
authors: Department of Pharmaceutical Science, Medical College of Hunan Normal University, Changsha 410013, PR China.
authors: Li-Hua
authors: LH
authors: He
authors: Department of Pharmaceutical Science, Medical College of Hunan Normal University, Changsha 410013, PR China.
authors: Jiao
authors: J
authors: Li
authors: Department of Pharmaceutical Science, Medical College of Hunan Normal University, Changsha 410013, PR China. Electronic address: dyxdjy@126.com.
authors: Yuan-Xiong
authors: YX
authors: Deng
authors: Department of Pharmaceutical Science, Medical College of Hunan Normal University, Changsha 410013, PR China; Department of pharmacy, Yangquan Coalmine Group General Hospital, Yangquan 045000, PR China.
authors: Xiao-Jie
authors: XJ
authors: Zhang
authors: Department of Pharmaceutical Science, Medical College of Hunan Normal University, Changsha 410013, PR China.
authors: Rong
authors: R
authors: Chen
authors: Department of Pharmaceutical Science, Medical College of Hunan Normal University, Changsha 410013, PR China.
authors: Yuan
authors: Y
authors: Lv
mesh_terms: D000284:Administration, Oral; D000818:Animals; D002851:Chromatography, High Pressure Liquid; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000188:drug therapy*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000188:drug therapy*; D032062:Gardenia / Q000737:chemistry*; D039823:Iridoids / Q000008:administration & dosage* / Q000737:chemistry / Q000493:pharmacokinetics* / Q000627:therapeutic use; D008297:Male; D010936:Plant Extracts / Q000008:administration & dosage* / Q000097:blood / Q000493:pharmacokinetics* / Q000627:therapeutic use; D017207:Rats, Sprague-Dawley; D012015:Reference Standards
chemical_list: D039823:Iridoids; D010936:Plant Extracts; C007835:geniposide
keywords: Fructus Gradeniae (Gardenia jasminoides Ellis); Geniposide; Pharmacokinetics; Type 2 diabetes