title: Low serum Insulin Like Growth Factor - 1 in patients with Stress Urinary Incontinence.
abstract: OBJECTIVE
  SUI, involuntary loss of urine, occurs when intra abdominal pressure exceeds urethral pressure in women. Recent animal study has shown that there are therapeutic effects of Insulin-like growth factors (IGF-1) on stress urinary incontinence in rats with simulated childbirth trauma. IGF-1 is an important mediator of cell growth, differentiation and transformation in various tissues and stimulates fibroblast proliferation and enhances collagen synthesis. The purpose of the current study was to determine the association between IGF-1 levels and SUI.
  
  
  METHODS
  All patients were evaluated for SUI and divided into two groups: 116 women with SUI and 76 women without SUI. Diagnosis of SUI was based on the International Consultation on Incontinence Questionnaire-Short Form (ICIQSF). Levels of IGF-1 were measured in serum by enzyme-linked immunosorbent assay. The relationship between IGF-1 levels and SUI in patients was evaluated statisticaly.
  
  
  RESULTS
  The mean age of patients wiyh SUI was 49.9±8.6 and 48.7±7.8 in control group. Plasma IGF-1 levels were significantly lower in SUI than in control group (106.5±26.4 and 133.3±37.1ng/mL, respectively, P <0.001). Body mass indexes were higher in women with SUI than women without SUI.
  
  
  CONCLUSIONS
  In this study lower serum IGF-1 levels were found to be associated with SUI. Serum IGF-1 level appears to be a specific predictor of SUI, and it may be used in early prediction of SUI in female population.
authors: Department Urology, Okmeydani Training and Research Hospital, Istanbul, Turkey.
authors: Emin
authors: E
authors: Ozbek
authors: Department Urology, Okmeydani Training and Research Hospital, Istanbul, Turkey.
authors: Alper
authors: A
authors: Otunctemur
authors: Department Urology, Okmeydani Training and Research Hospital, Istanbul, Turkey.
authors: Suleyman
authors: S
authors: Sahin
authors: Department Urology, Derince Training and Research Hospital, Kocaeli, Turkey.
authors: Levent
authors: L
authors: Ozcan
authors: Department Urology, Bahcelievler State Hospital, Istanbul, Turkey.
authors: Murat
authors: M
authors: Dursun
authors: Department of Urology, School of Medicine, Istanbul Medipol University, Istanbul, Turkey.
authors: Emrecan
authors: E
authors: Polat
authors: Department of Biochemistry, Namik Kemal University Medical Faculty, Tekirdag, Turkey.
authors: Feti
authors: F
authors: Tulubas
authors: Department of Medeniyet University Medical Faculty, Istanbul, Turkey.
authors: Mustafa
authors: M
authors: Cekmen
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D003094:Collagen / Q000096:biosynthesis; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000032:analysis / Q000378:metabolism*; D008875:Middle Aged; D011446:Prospective Studies; D014550:Urinary Incontinence, Stress / Q000097:blood*
chemical_list: D007334:Insulin-Like Growth Factor I; D003094:Collagen
keywords: Enzyme-Linked Immunosorbent Assay; Insulin-Like Growth Factor I; Urinary Incontinence, Stress