title: Linear and branched polyacrylates as a delivery platform for peptide-based vaccines.
abstract: Peptide-based vaccines are designed to carry the minimum required antigen to trigger the desired immune responses; however, they are usually poorly immunogenic and require appropriate delivery system.
  
  
  
  Peptides, B-cell epitope (J14) derived from group A streptococcus M-protein and universal T-helper (PADRE) epitope, were conjugated to a variety of linear and branched polyacrylates. All produced conjugates formed submicron-sized particles and induced a high level of IgG titres in mice after subcutaneous immunization. These polymer-peptide conjugates demonstrated high opsonization capacity against group A streptococcus clinical isolates.
  
  
  
  We have successfully demonstrated that submicron-sized polymer-peptide conjugates were capable of inducing strong humoral immune responses after single immunization.
authors: School of Chemistry & Molecular Biosciences, The University of Queensland, St Lucia, QLD 4072, Australia.
authors: Saranya
authors: S
authors: Chandrudu
authors: School of Chemistry & Molecular Biosciences, The University of Queensland, St Lucia, QLD 4072, Australia.
authors: Stacey
authors: S
authors: Bartlett
authors: Institute for Molecular Biosciences, The University of Queensland, St Lucia, QLD 4072, Australia.
authors: Zeinab G
authors: ZG
authors: Khalil
authors: Australian Institute for Bioengineering & Nanotechnology, The University of Queensland, St Lucia, QLD 4072, Australia.
authors: Zhongfan
authors: Z
authors: Jia
authors: School of Chemistry & Molecular Biosciences, The University of Queensland, St Lucia, QLD 4072, Australia.
authors: Waleed M
authors: WM
authors: Hussein
authors: Institute for Molecular Biosciences, The University of Queensland, St Lucia, QLD 4072, Australia.
authors: Robert J
authors: RJ
authors: Capon
authors: Institute for Glycomics, Griffith University, Gold Coast, QLD 4222, Australia.
authors: Michael R
authors: MR
authors: Batzloff
authors: Institute for Glycomics, Griffith University, Gold Coast, QLD 4222, Australia.
authors: Michael F
authors: MF
authors: Good
authors: Australian Institute for Bioengineering & Nanotechnology, The University of Queensland, St Lucia, QLD 4072, Australia.
authors: Michael J
authors: MJ
authors: Monteiro
authors: School of Chemistry & Molecular Biosciences, The University of Queensland, St Lucia, QLD 4072, Australia.
authors: Mariusz
authors: M
authors: Skwarczynski
authors: School of Chemistry & Molecular Biosciences, The University of Queensland, St Lucia, QLD 4072, Australia.|Institute for Molecular Biosciences, The University of Queensland, St Lucia, QLD 4072, Australia.|School of Pharmacy, The University of Queensland, Woolloongabba, QLD 4102, Australia.
authors: Istvan
authors: I
authors: Toth
mesh_terms: D000180:Acrylic Resins / Q000737:chemistry*; D000818:Animals; D000942:Antigens, Bacterial / Q000008:administration & dosage*; D001425:Bacterial Outer Membrane Proteins / Q000008:administration & dosage*; D002352:Carrier Proteins / Q000008:administration & dosage*; D018985:Epitopes, B-Lymphocyte / Q000008:administration & dosage*; D018984:Epitopes, T-Lymphocyte / Q000008:administration & dosage*; D007114:Immunization; D051379:Mice; D010455:Peptides / Q000008:administration & dosage; D022223:Vaccines, Subunit / Q000008:administration & dosage*
chemical_list: D000180:Acrylic Resins; D000942:Antigens, Bacterial; D001425:Bacterial Outer Membrane Proteins; D002352:Carrier Proteins; D018985:Epitopes, B-Lymphocyte; D018984:Epitopes, T-Lymphocyte; D010455:Peptides; D022223:Vaccines, Subunit; C014689:streptococcal M protein; C006903:carbopol 940
keywords: clinical isolates; group A streptococcus; nanoparticles; opsonization; peptide vaccine; polyacrylates; polymer–peptide conjugate; single immunization; vaccine delivery