title: [HLA DRB1*, DQB1*, DPA1*, and DPB1* and their association with the pathogenesis of leukemia in the population of Venezuela].
abstract: The HLA complex involved is a factor in the pathogenesis of leukemia.
  
  
  
  The presence of class II HLA alleles DRB1 *, DQB1 *, DPA1 *, and DPB1 * was evaluated in 47 patients with acute lymphoblastic leukemia (ALL) and 48 with chronic myeloid leukemia (CML) for comparison with 48 healthy volunteers in Zulia, Venezuela, and to evaluate potential associations of HLA with leukemia.
  
  
  
  Low- and high-resolution PCR-SSP was used for class II HLA regions DRB1 *, DQB1 *, DPA1 *, and DPB1 * following the instructions of KIT Olerup SSP Genovision.
  
  
  
  Alleles HLA-DRB1*14, especially DRB1*14:21, -DPA1*1:06, -DPA1*01:03,-DPA1*02:01, and the haplotypes HLA-DPA1*01:03-DPB1*04:01, DPA1*01:03-DPB1*02:01, DPA1*01:03-DPB1*99:01, -DRB1*14-DPA1*01:03, -DRB1*15-DPA1*01:03 were associated with CML (RR > 3); alleles HLA-DRB1*13, -DQB1*02, -DPA1*01:05, -DPA1*01:09 and the haplotypes HLA-DPA1*01:09-DPB1*02:01, DPA1*01:09-DPB1*04:01 were protective (RR < 1). Alleles HLA-DQB1*04, -DQB1*05, -DPA1*1:06, -DPA1*01:07, -DPA1*1:08 had a positive association with ALL. Alleles HLA-DPA1*01:09, -DPA1*02:01, -DPB1*02:01, -DPB1*03:01 and the haplotypes HLA-DPA1*01:03-DPB1*04:02, -DPA1*01:09-DPB1*02:01, -DPA1*01:09-DPB1*04:01, -DPA1*02:01-DPB1*04:02 were negatively associated.
  
  
  
  The other association patterns identified suggest marked differences in the pathogenesis of leukemia, which suggests possible deficiencies in antigen presentation for ALL or potential effects of molecular mimicry in CML.
authors: Universidad del Zulia, Faculta de Medicina, División de Investigación, Maracaibo, Zulia, Venezuela. sergio.rivera54@hotmail.es.
authors: Sergio E
authors: SE
authors: Rivera-Pirela
authors: Miriam
authors: M
authors: Echeverría
authors: Pedro
authors: P
authors: Salcedo
authors: Georgina
authors: G
authors: Márquez
authors: Zuhey
authors: Z
authors: Carrillo
authors: Yennis
authors: Y
authors: Parra
authors: Ana María
authors: AM
authors: Cipriani
authors: José R
authors: JR
authors: Núñez
authors: Melchor
authors: M
authors: Álvarez de Mon
mesh_terms: D000483:Alleles; D006681:HLA-D Antigens / Q000235:genetics / Q000276:immunology*; D059866:HLA-DQ beta-Chains / Q000276:immunology; D059811:HLA-DRB1 Chains / Q000235:genetics / Q000276:immunology; D006239:Haplotypes; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000276:immunology*; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000276:immunology*; D014687:Venezuela
chemical_list: D006681:HLA-D Antigens; D059866:HLA-DQ beta-Chains; C057615:HLA-DQbeta antigen; D059811:HLA-DRB1 Chains
keywords: Acute lymphocytic leukemia; Chronic myelogenous leukemia; Human leukocyte antigens; Venezuelan mestizo population