title: Flavoniods from aerial parts of Astragalus hoantchy.
abstract: Four new flavonoids, astragaisoflavans A-D (1-4), along with thirteen known ones (5-17) were isolated from the aerial parts of Astragalus hoantchy. Their structures were established by the extensive spectroscopic analyses including one- and two-dimensional NMR, HRESIMS, IR, and UV results. The absolute configurations of 1-4 were deduced based on circular dichroism. Compounds 1-3 all possessed a rare modified A-ring and compound 4 was a dimeric isoflavan. Compound 5 was first identified from genus Astragalus and 6-17 were found from A. hoantchy for the first time. Compound 1 and 4 were evaluated for their antifungal activity against Alternaria solani (a phytopathogenic fungus), with the result that 1 failed to exhibit significant antifungal activity at the testing concentration of 100μg/mL and the IC50value of 4 was 173.3μg/mL.
authors: Key Laboratory of Chemistry of Northwestern Plant Resources of CAS and Key Laboratory for Natural Medicine of Gansu Province, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000, PR China.
authors: Kai
authors: K
authors: Guo
authors: Key Laboratory of Chemistry of Northwestern Plant Resources of CAS and Key Laboratory for Natural Medicine of Gansu Province, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000, PR China.
authors: Xiaofeng
authors: X
authors: He
authors: Fisheries Research Institute of Gansu Province, Lanzhou 730030, PR China.
authors: Yanping
authors: Y
authors: Zhang
authors: Key Laboratory of Chemistry of Northwestern Plant Resources of CAS and Key Laboratory for Natural Medicine of Gansu Province, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000, PR China.
authors: Xiuzhuang
authors: X
authors: Li
authors: Key Laboratory of Chemistry of Northwestern Plant Resources of CAS and Key Laboratory for Natural Medicine of Gansu Province, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000, PR China.
authors: Zhiqiang
authors: Z
authors: Yan
authors: Key Laboratory of Chemistry of Northwestern Plant Resources of CAS and Key Laboratory for Natural Medicine of Gansu Province, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000, PR China.
authors: Le
authors: L
authors: Pan
authors: Key Laboratory of Chemistry of Northwestern Plant Resources of CAS and Key Laboratory for Natural Medicine of Gansu Province, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000, PR China. Electronic address: bqin@licp.cas.cn.
authors: Bo
authors: B
authors: Qin
mesh_terms: D000528:Alternaria / Q000187:drug effects; D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification; D027883:Astragalus Plant / Q000737:chemistry*; D005419:Flavonoids / Q000737:chemistry* / Q000302:isolation & purification; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D035261:Plant Components, Aerial / Q000737:chemistry
chemical_list: D000935:Antifungal Agents; D005419:Flavonoids
keywords: Antifungal activity; Astragalus hoantchy; Flavonoids; Leguminosae