title: Supramolecular assistance between cyclodextrins and didecyldimethylammonium chloride against enveloped viruses: Toward eco-biocidal formulations.
abstract: Nosocomial infections have emerged as important causes of morbidity and mortality in immunocompromised individuals. In this respect, biocides are widely used in hospitals leading to resistant microorganisms. We show here that cyclodextrins can remarkably boost the virucidal activity of di-n-decyldimethylammonium chloride. These oligosaccharides synergistically work with the biocide affording a noticeable reduction of the active virucide concentration between 40 and 85%. Partial replacement of a significant amount of the biocide by eco- and bio-compatible cyclodextrins whilst maintaining the same activity is of great interest as it allows the reduction of the toxicological drawbacks of classical biocide mixtures.
authors: Univ. Lille, CNRS, ENSCL, UMR 8181-UCCS-Unité de Catalyse et Chimie du Solide-Equipe CÏSCO, F-59000 Lille, France. Electronic address: loic.leclercq@univ-lille1.fr.
authors: Loïc
authors: L
authors: Leclercq
authors: Univ. Lille, Faculté de Médecine, UPRES EA 3610, Institut de Microbiologie, Laboratoire de Virologie, CHRU Lille, F-59037 Lille Cedex, France.
authors: Anny
authors: A
authors: Dewilde
authors: Univ. Lille, CNRS, ENSCL, UMR 8181-UCCS-Unité de Catalyse et Chimie du Solide-Equipe CÏSCO, F-59000 Lille, France.
authors: Jean-Marie
authors: JM
authors: Aubry
authors: Univ. Lille, CNRS, ENSCL, UMR 8181-UCCS-Unité de Catalyse et Chimie du Solide-Equipe CÏSCO, F-59000 Lille, France. Electronic address: veronique.rataj@univ-lille1.fr.
authors: Véronique
authors: V
authors: Nardello-Rataj
mesh_terms: D003505:Cyclodextrins / Q000737:chemistry / Q000494:pharmacology*; D004202:Disinfectants / Q000737:chemistry* / Q000494:pharmacology; D004357:Drug Synergism; D008826:Microbial Sensitivity Tests; D000644:Quaternary Ammonium Compounds / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D013500:Surface Tension / Q000187:drug effects; D013816:Thermodynamics; D014780:Viruses / Q000187:drug effects*
chemical_list: D003505:Cyclodextrins; D004202:Disinfectants; D000644:Quaternary Ammonium Compounds; C585361:di-n-decyldimethylammonium chloride
keywords: Cyclodextrins; Di-n-decyldimethylammonium chloride; Eco-biocide; Host-Guest chemistry; Lipids extraction; Synergistic formulation; Virus inactivation