title: Population study and mutation analysis for 28 short tandem repeat loci in southwest Chinese Han population.
abstract: Short tandem repeat (STR) system is the most widely used genetic markers in modem forensic practice. Because of the relatively unstable molecular structure, STRs show a high mutation rate. In the current study, we report 169 mutation events of 13 CODIS and 15 non-CODIS STR loci that were found in 5569 cases of trios and duos paternity test. Our result indicated that locus-specific mutation rate varied among different populations, geometric means of the longest run of perfect repeats (LRPR) and heterozygosity. Along with previous published data, a forensic dataset for allele frequencies and locus-specific mutation rates of 13 CODIS and 15 non-CODIS STR loci from southwest Chinese Han population has been established. The mutation rate data have important implications in interpreting forensic individual identification and paternity testing.
authors: Department of Forensic Genetics, West China School of Basic Science and Forensic Medicine, Sichuan University (West China University of Medical Sciences), Chengdu 610041, PR China.
authors: Qin
authors: Q
authors: Su
authors: Department of Forensic Genetics, West China School of Basic Science and Forensic Medicine, Sichuan University (West China University of Medical Sciences), Chengdu 610041, PR China; Department of Forensic Medicine, North Sichuan Medical College, Nanchong 637000, PR China.
authors: Bo
authors: B
authors: Jin
authors: Department of Forensic Genetics, West China School of Basic Science and Forensic Medicine, Sichuan University (West China University of Medical Sciences), Chengdu 610041, PR China.
authors: Haibo
authors: H
authors: Luo
authors: Department of Forensic Genetics, West China School of Basic Science and Forensic Medicine, Sichuan University (West China University of Medical Sciences), Chengdu 610041, PR China.
authors: Yingbi
authors: Y
authors: Li
authors: Department of Forensic Genetics, West China School of Basic Science and Forensic Medicine, Sichuan University (West China University of Medical Sciences), Chengdu 610041, PR China.
authors: Jin
authors: J
authors: Wu
authors: Department of Forensic Genetics, West China School of Basic Science and Forensic Medicine, Sichuan University (West China University of Medical Sciences), Chengdu 610041, PR China.
authors: Jing
authors: J
authors: Yan
authors: Department of Forensic Genetics, West China School of Basic Science and Forensic Medicine, Sichuan University (West China University of Medical Sciences), Chengdu 610041, PR China.
authors: Yiping
authors: Y
authors: Hou
authors: Department of Forensic Genetics, West China School of Basic Science and Forensic Medicine, Sichuan University (West China University of Medical Sciences), Chengdu 610041, PR China. Electronic address: liangweibo@gmail.com.
authors: Weibo
authors: W
authors: Liang
authors: Department of Forensic Genetics, West China School of Basic Science and Forensic Medicine, Sichuan University (West China University of Medical Sciences), Chengdu 610041, PR China. Electronic address: zhanglin@scu.edu.cn.
authors: Lin
authors: L
authors: Zhang
mesh_terms: D002681:China; D016172:DNA Fingerprinting; D005006:Ethnicity / Q000235:genetics*; D005787:Gene Frequency; D005828:Genetics, Population; D006579:Heterozygote; D006801:Humans; D018895:Microsatellite Repeats; D009154:Mutation
keywords: Forensic practice; Mutations; Population genetics; Short tandem repeats; Southwestern China