title: Solid super saturated self-nanoemulsifying drug delivery system (sat-SNEDDS) as a promising alternative to conventional SNEDDS for improvement rosuvastatin calcium oral bioavailability.
abstract: OBJECTIVE
  This study aims to illustrate the applicability of solid supersaturated self-nanoemulsifying drug delivery system (sat-SNEDDS) for the improvement of rosuvastatin calcium (RC) oral bioavailability.
  
  
  METHODS
  Different sat-SNEDDS were prepared by incorporating different ratios of RC into SNEDDS using tween80/PEG400 (77.2%) as surfactant/cosurfactant mixture and garlic /olive oil (22.8%) as oil phase. The prepared systems were characterized viz; size, zeta potential, TEM and stability. Various hydrophilic and hydrophobic carriers were employed to solidify the optimized RC sat-SNEDDS. The influence of the carrier was investigated by SEM, XRPD, DSC, flow properties, in vitro precipitation, drug release and oral bioavailability study.
  
  
  RESULTS
  The adsorption of the stable positively charged nanocarrier RC sat-SNEDDS onto solid carriers provided free flowing amorphous powder. The carrier could amend the morphological architecture and in vitro release of the RC solid sat-SNEDDS. Hydrophobic carriers as microcrystalline cellulose 102 (MCC) showed superior physical characters and higher dissolution rate over hydrophilic carriers as maltodextrin with respective T100%30 min and 45 min. The rapid spontaneous emulsification, the positively nanosized MCC-sat-SNEDDS improved oral bioavailability of RC by 2.1-fold over commercial tablets.
  
  
  CONCLUSIONS
  Solid MCC-sat-SNEDDS combined dual benefits of sat-SNEDDS and solid dosage form was successfully optimized to improve RC oral bioavailability.
authors: a Pharmaceutics Department , National Organization of Drug Control and Research (NODCAR) , Giza , Egypt.
authors: Hadel A
authors: HA
authors: Abo Enin
authors: a Pharmaceutics Department , National Organization of Drug Control and Research (NODCAR) , Giza , Egypt.
authors: Hend Mohamed
authors: HM
authors: Abdel-Bar
mesh_terms: D000284:Administration, Oral; D000818:Animals; D001682:Biological Availability; D016503:Drug Delivery Systems; D065546:Drug Liberation; D004655:Emulsions; D057927:Hydrophobic and Hydrophilic Interactions; D008297:Male; D053758:Nanoparticles; D010316:Particle Size; D011092:Polyethylene Glycols / Q000737:chemistry; D051381:Rats; D000068718:Rosuvastatin Calcium / Q000008:administration & dosage*; D012995:Solubility; D013501:Surface-Active Agents / Q000737:chemistry; D013607:Tablets
chemical_list: D004655:Emulsions; D013501:Surface-Active Agents; D013607:Tablets; D011092:Polyethylene Glycols; D000068718:Rosuvastatin Calcium
keywords: Rosuvastatin calcium; oral bioavailability; solid carriers; solid self-nanoemulsifying drug delivery system; supersaturated self-nanoemulsifying drug delivery system