title: Additional New Cytotoxic Triquinane-Type Sesquiterpenoids Chondrosterins K-M from the Marine Fungus Chondrostereum sp.
abstract: By the method of ¹H NMR prescreening and tracing the diagnostic proton signals of the methyl groups, three additional new triquinane-type sesquiterpenoids-chondrosterins K-M (1-3) and the known sesquiterpenoid anhydroarthrosporone (4)-were isolated from the marine fungus Chondrostereum sp. Their structures were elucidated on the basis of MS, 1D, and 2D NMR data. Chondrosterin K is a rare hirsutane sesquiterpenoid, in which a methyl group was migrated from C-2 to C-6 and has a double bond between C-2 and C-3. Compounds 1-3 showed significant cytotoxicities against various cancer cell lines in vitro.
authors: School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou 510275, China. marinehuangl@gmail.com.
authors: Lei
authors: L
authors: Huang
authors: School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China. lanwj@mail.sysu.edu.cn.|Guangdong Technology Research Center for Advanced Chinese Medicine, Guangzhou 510006, China. lanwj@mail.sysu.edu.cn.
authors: Wen-Jian
authors: WJ
authors: Lan
authors: State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Cancer Center, Sun Yat-sen University, Guangzhou 510060, China. dengrong@sysucc.org.cn.
authors: Rong
authors: R
authors: Deng
authors: State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Cancer Center, Sun Yat-sen University, Guangzhou 510060, China. fenggk@sysucc.org.cn.
authors: Gong-Kan
authors: GK
authors: Feng
authors: School of Life Sciences, Xiamen University, Xiamen 361102, China. xuqingyan@xmu.edu.cn.
authors: Qing-Yan
authors: QY
authors: Xu
authors: School of Life Sciences, Xiamen University, Xiamen 361102, China. huzhiyu@xmu.edu.cn.
authors: Zhi-Yu
authors: ZY
authors: Hu
authors: State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Cancer Center, Sun Yat-sen University, Guangzhou 510060, China. zhuxfeng@mail.sysu.edu.cn.
authors: Xiao-Feng
authors: XF
authors: Zhu
authors: School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou 510275, China. ceslhj@mail.sysu.edu.cn.
authors: Hou-Jin
authors: HJ
authors: Li
mesh_terms: D000818:Animals; D037421:Anthozoa / Q000382:microbiology; D000903:Antibiotics, Antineoplastic / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor; D005285:Fermentation; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008968:Molecular Conformation; D020072:Polyporales / Q000737:chemistry*; D012623:Seawater / Q000382:microbiology; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D021241:Spectrometry, Mass, Electrospray Ionization
chemical_list: D000903:Antibiotics, Antineoplastic; D012717:Sesquiterpenes; C000619571:chondrosterin K; C000619555:chondrosterin L; C000619556:chondrosterin M
keywords: Chondrostereum sp.; chondrosterin; cytotoxicity; hirsutane; sesquiterpenoid