title: How neutrophils kill fungi.
abstract: Neutrophils play a critical role in the prevention of invasive fungal infections. Whereas mouse studies have demonstrated the role of various neutrophil pathogen recognition receptors (PRRs), signal transduction pathways, and cytotoxicity in the murine antifungal immune response, much less is known about the killing of fungi by human neutrophils. Recently, novel primary immunodeficiencies have been identified in patients with a susceptibility to fungal infections. These human 'knock-out' neutrophils expand our knowledge to understand the role of PRRs and signaling in human fungal killing. From the studies with these patients it is becoming clear that neutrophils employ fundamentally distinct mechanisms to kill Candida albicans or Aspergillus fumigatus.
authors: Sanquin Research, and Landsteiner Laboratory, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.|Emma Children's Hospital, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.
authors: Roel P
authors: RP
authors: Gazendam
authors: Sanquin Research, and Landsteiner Laboratory, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.
authors: Annemarie
authors: A
authors: van de Geer
authors: Sanquin Research, and Landsteiner Laboratory, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.
authors: Dirk
authors: D
authors: Roos
authors: Sanquin Research, and Landsteiner Laboratory, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.
authors: Timo K
authors: TK
authors: van den Berg
authors: Sanquin Research, and Landsteiner Laboratory, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.|Emma Children's Hospital, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.
authors: Taco W
authors: TW
authors: Kuijpers
mesh_terms: D000818:Animals; D001232:Aspergillus fumigatus / Q000276:immunology*; D002176:Candida albicans / Q000276:immunology*; D003602:Cytotoxicity, Immunologic; D006801:Humans; D007113:Immunity, Innate; D051379:Mice; D009181:Mycoses / Q000276:immunology*; D009504:Neutrophils / Q000276:immunology* / Q000382:microbiology; D051192:Receptors, Pattern Recognition / Q000378:metabolism; D015398:Signal Transduction
chemical_list: D051192:Receptors, Pattern Recognition
keywords: CARD9; CR3; NADPH oxidase; NET formation; dectin-1; neutrophil