title: Combined Expression of c-jun, c-fos, and p53 Improves Estimation of Prognosis in Oral Squamous Cell Carcinoma.
abstract: To identify the prognostic value of c-jun, c-fos, and p53 in oral cancer, we examined the impact of immunohistochemical expression of these markers on tumor progression in 157 oral squamous cell carcinoma (OSCC). We found that c-jun or c-fos was significantly associated with lymph node metastasis, and coexpression of c-jun/c-fos, or c-jun/c-fos/p53 were significantly associated with lymph node metastasis, poor differentiation and clinical stage. The coexpression of c-jun/c-fos/p53 was identified as independent prognostic factors for overall survival. Simultaneous coexpression of these markers in OSCCs might prove to be a useful indicator for differentiation of low and high-risk patients.
authors: a Department of Oral Pathology , Hospital of Stomatology, the First Affiliated Hospital, Harbin Medical University , Harbin , China.
authors: Shan
authors: S
authors: Wang
authors: b Department of Oral Medicine , Heilongjiang Nursing College , Harbin , China.
authors: Xin
authors: X
authors: Xu
authors: a Department of Oral Pathology , Hospital of Stomatology, the First Affiliated Hospital, Harbin Medical University , Harbin , China.
authors: Fei
authors: F
authors: Xu
authors: a Department of Oral Pathology , Hospital of Stomatology, the First Affiliated Hospital, Harbin Medical University , Harbin , China.
authors: Yan
authors: Y
authors: Meng
authors: a Department of Oral Pathology , Hospital of Stomatology, the First Affiliated Hospital, Harbin Medical University , Harbin , China.
authors: Changsheng
authors: C
authors: Sun
authors: a Department of Oral Pathology , Hospital of Stomatology, the First Affiliated Hospital, Harbin Medical University , Harbin , China.
authors: Lei
authors: L
authors: Shi
authors: a Department of Oral Pathology , Hospital of Stomatology, the First Affiliated Hospital, Harbin Medical University , Harbin , China.
authors: Eryang
authors: E
authors: Zhao
mesh_terms: D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor; D002294:Carcinoma, Squamous Cell / Q000175:diagnosis / Q000378:metabolism* / Q000401:mortality*; D005260:Female; D005500:Follow-Up Studies; D015870:Gene Expression; D006801:Humans; D007150:Immunohistochemistry; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000175:diagnosis / Q000378:metabolism* / Q000401:mortality*; D009367:Neoplasm Staging; D011379:Prognosis; D016760:Proto-Oncogene Proteins c-fos / Q000235:genetics / Q000378:metabolism*; D016755:Proto-Oncogene Proteins c-jun / Q000235:genetics / Q000378:metabolism*; D016159:Tumor Suppressor Protein p53 / Q000235:genetics / Q000378:metabolism*
chemical_list: D014408:Biomarkers, Tumor; D016760:Proto-Oncogene Proteins c-fos; D016755:Proto-Oncogene Proteins c-jun; D016159:Tumor Suppressor Protein p53
keywords: Oral squamous cell carcinoma; c-fos; c-jun; p53