title: Curdlan in fibers as carriers of tetracycline hydrochloride: Controlled release and antibacterial activity.
abstract: Curdlan (CURD) and polyethylene oxide were used to synthesize nanofibers as carriers of hydro soluble tetracycline hydrochloride (TCH). The viscosity, surface tension and conductivity of the precursor multicomponent aqueous solutions were determined and adjusted to produce defect-free fiber webs. Except for a slight increase in diameter, the addition of TCH did not affect the original morphology of the CURD/PEO nanofibers, as determined by FE-SEM imaging. However, the thermal stability of the system was enhanced (TGA and DSC). Moreover, water resistance, as measured with 24-h immersion tests, was observed upon crosslinking with glutaraldehyde. In-vitro activity measurements indicated a sustained and controlled TCH time-release pattern and excellent antibacterial activity against E. coli, as assessed by UV-vis spectroscopy and viable cell counting, respectively. Overall, we propose nanofibers based on CURD as promising platforms for scaffolds for wound dressing and drug delivery.
authors: Textile Research Division, Scopus affiliation ID 60014618, 33 El Bohouth st.-Dokki-Giza, Cairo, Egypt; Biobased Colloids and Materials Group (BiCMat), Department of Forest Biomaterials, North Carolina State University, Campus Box 8005, NC 27695, United States. Electronic address: mehrez_chem@yahoo.com.
authors: Mehrez E
authors: ME
authors: El-Naggar
authors: Textile Research Division, Scopus affiliation ID 60014618, 33 El Bohouth st.-Dokki-Giza, Cairo, Egypt; Biobased Colloids and Materials Group (BiCMat), Department of Forest Biomaterials, North Carolina State University, Campus Box 8005, NC 27695, United States.
authors: Abdelrahman M
authors: AM
authors: Abdelgawad
authors: Biobased Colloids and Materials Group (BiCMat), Department of Forest Biomaterials, North Carolina State University, Campus Box 8005, NC 27695, United States.
authors: Carlos
authors: C
authors: Salas
authors: Biobased Colloids and Materials Group (BiCMat), Department of Forest Biomaterials, North Carolina State University, Campus Box 8005, NC 27695, United States; Department of Forest Products Technology, Aalto University, P. O. Box 16300, FIN-00076 Aalto, Finland.
authors: Orlando J
authors: OJ
authors: Rojas
mesh_terms: D000890:Anti-Infective Agents / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D002152:Calorimetry, Differential Scanning; D003432:Cross-Linking Reagents / Q000737:chemistry; D003692:Delayed-Action Preparations; D004337:Drug Carriers / Q000737:chemistry*; D004926:Escherichia coli / Q000187:drug effects / Q000254:growth & development; D005976:Glutaral / Q000737:chemistry; D008855:Microscopy, Electron, Scanning; D057139:Nanofibers / Q000737:chemistry*; D011092:Polyethylene Glycols / Q000737:chemistry; D012212:Rheology; D012995:Solubility; D013056:Spectrophotometry, Ultraviolet; D017550:Spectroscopy, Fourier Transform Infrared; D013499:Surface Properties; D013752:Tetracycline / Q000737:chemistry* / Q000493:pharmacokinetics* / Q000494:pharmacology; D047071:beta-Glucans / Q000737:chemistry* / Q000493:pharmacokinetics
chemical_list: D000890:Anti-Infective Agents; D003432:Cross-Linking Reagents; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D047071:beta-Glucans; D011092:Polyethylene Glycols; C038459:curdlan; D013752:Tetracycline; D005976:Glutaral
keywords: Antibacterial; Curdlan; Drug delivery; Electrospinning; Nanofibers; Tetracycline hydrochloride