title: Development of a Fiber-Optic Optical Coherence Tomography Probe for Intraocular Use.
abstract: To evaluate the performance of a newly developed 23-G optical coherence tomography (OCT) probe in animal and human eyes.
  
  
  
  The probe is a side-imaging OCT device with a scanning beam set 43° to the optical axis and a working distance of 1.5 to 2.0 mm. The performance of the OCT probe was tested during vitrectomy in porcine cadaver eyes and rabbit eyes in situ. Optical coherence tomography images of a normal retina, retinal break, optic disc, pars plicata of the ciliary body, and intraoperative surgical manipulations were recorded. The probe was also tested in a pilot study of clinical cases; intraoperative real-time OCT imaging was performed in three patients, including a 56-year-old woman with an epiretinal membrane.
  
  
  
  The OCT probe was able to delineate intraocular tissues, including the posterior retina, and even the most peripheral pars plicata in animal eyes. The OCT probe also successfully delineated intraoperative surgical maneuvers such as membrane peeling and the minute structures of the vortex veins, ora serrata, and vitreous incarceration in the scleral incision from the trocar with sufficient resolution in the patients. There were no complications resulting from its use.
  
  
  
  The ability of this new 23-G OCT probe to obtain images of intraoperative manipulations from the most peripheral tissues in animal and patient eyes suggests that it could enable surgeons to make better decisions during the course of intraocular surgery.
authors: Department of Ophthalmology Nagoya University Graduate School of Medicine, Showa-ku, Nagoya, Aichi, Japan.
authors: Tetsu
authors: T
authors: Asami
authors: Department of Ophthalmology Nagoya University Graduate School of Medicine, Showa-ku, Nagoya, Aichi, Japan.
authors: Hiroko
authors: H
authors: Terasaki
authors: Department of Ophthalmology Nagoya University Graduate School of Medicine, Showa-ku, Nagoya, Aichi, Japan.
authors: Yasuki
authors: Y
authors: Ito
authors: Department of Ophthalmology Nagoya University Graduate School of Medicine, Showa-ku, Nagoya, Aichi, Japan.
authors: Tadasu
authors: T
authors: Sugita
authors: Department of Ophthalmology Nagoya University Graduate School of Medicine, Showa-ku, Nagoya, Aichi, Japan.
authors: Hiroki
authors: H
authors: Kaneko
authors: NIDEK Co. Ltd., 34-14, Maehama, Hiroishi-cho, Gamagori, Aichi, Japan.
authors: Junpei
authors: J
authors: Nishiyama
authors: NIDEK Co. Ltd., 34-14, Maehama, Hiroishi-cho, Gamagori, Aichi, Japan.
authors: Hajime
authors: H
authors: Namiki
authors: NIDEK Co. Ltd., 34-14, Maehama, Hiroishi-cho, Gamagori, Aichi, Japan.
authors: Masahiko
authors: M
authors: Kobayashi
authors: Department of Electrical Engineering and Computer Science, Nagoya University, Furo-cho, Chikusa-ku, Nagoya, Aichi, Japan.
authors: Norihiko
authors: N
authors: Nishizawa
mesh_terms: D000818:Animals; D004867:Equipment Design; D005260:Female; D006801:Humans; D007432:Intraoperative Period; D008875:Middle Aged; D010865:Pilot Projects; D011817:Rabbits; D015203:Reproducibility of Results; D012160:Retina / Q000000981:diagnostic imaging*; D012164:Retinal Diseases / Q000175:diagnosis* / Q000601:surgery; D025321:Surgery, Computer-Assisted / Q000379:methods*; D013552:Swine; D041623:Tomography, Optical Coherence / Q000295:instrumentation* / Q000639:trends*