title: In vivo17O MRS imaging - Quantitative assessment of regional oxygen consumption and perfusion rates in living brain.
abstract: In the last decade, in vivo oxygen-17 (17O) MRS has evolved into a promising MR technique for noninvasively studying oxygen metabolism and perfusion in aerobic organs with the capability of imaging the regional metabolic rate of oxygen and its changes. In this chapter, we will briefly review the methodology of the in vivo17O MRS technique and its recent development and applications; we will also discuss the advantages of the high/ultrahigh magnetic field for17O MR detection, as well as the challenges and potential of this unique MRS method for biomedical research of oxygen metabolism, mitochondrial function and tissue energetics in health and disease.
authors: Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota, School of Medicine, Minneapolis, MN, USA. Electronic address: zhu@cmrr.umn.edu.
authors: Xiao-Hong
authors: XH
authors: Zhu
authors: Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota, School of Medicine, Minneapolis, MN, USA.
authors: Wei
authors: W
authors: Chen
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism*; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D008928:Mitochondria / Q000378:metabolism*; D008954:Models, Biological; D010101:Oxygen Consumption; D010104:Oxygen Radioisotopes / Q000032:analysis* / Q000378:metabolism; D010477:Perfusion
chemical_list: D010104:Oxygen Radioisotopes