title: Cerebral blood perfusion changes in amputees with myoelectric hands after rehabilitation: a SPECT computer-aided analysis.
abstract: Rehabilitation, which is essential for amputees with myoelectric hands, can improve the quality of daily life by remodeling the neuron network. In our study, we aim to develop a cerebral blood perfusion (CBF) single-photon emission computed tomography computer-aided (SPECT-CA) detection scheme to automatically locate the brain's activated regions after rehabilitation.
  
  
  
  Five participants without forearms (three male, two female, mean age 51 ± 12.89 years, two missing the right side, and three missing the left side) were included in our study. In the clinical assessment, all of the participants received higher scores after training. The results of the SPM analysis indicated that CBF in the precentral gyrus, postcentral gyrus, frontal lobe, temporal lobe and cerebellum was significantly different among the five participants (P < 0.05). Moreover, SPECT-CA showed that the activated brain areas mainly included the precentral gyrus, postcentral gyrus, cerebellum and extensive cerebral cortex.
  
  
  
  Our study demonstrated that the CBF SPECT-CA method can detect the brain blood perfusion changes induced by rehabilitation with high sensitivity and accuracy. This method has great potential for locating the remodeled neuron regions of amputees with myoelectric hands after rehabilitation.
authors: Department of Nuclear Medicine, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, 160 Pujian Road, Shanghai, 200127, China.
authors: Qiufang
authors: Q
authors: Liu
authors: Department of Automation, School of Electrical Engineering Information, Sichuan University, Sichuan, 610065, China.
authors: Xiujuan
authors: X
authors: Zheng
authors: Department of Nuclear Medicine, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, 160 Pujian Road, Shanghai, 200127, China.
authors: Panli
authors: P
authors: Li
authors: Department of Nuclear Medicine, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, 160 Pujian Road, Shanghai, 200127, China.
authors: Lian
authors: L
authors: Xu
authors: Shanghai Rehabilitation and Vocational Training Center for the Disabled, Shanghai, 200127, China.
authors: Longwen
authors: L
authors: He
authors: Shanghai Rehabilitation and Vocational Training Center for the Disabled, Shanghai, 200127, China.
authors: Zhao
authors: Z
authors: Mei
authors: Department of Nuclear Medicine, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, 160 Pujian Road, Shanghai, 200127, China.
authors: Yinyan
authors: Y
authors: Zhu
authors: Department of Nuclear Medicine, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, 160 Pujian Road, Shanghai, 200127, China.
authors: Gang
authors: G
authors: Huang
authors: Department of Neurosurgery, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, 160 Pujian Road, Shanghai, 200127, China. drchunlongzhong@126.com.
authors: Chunlong
authors: C
authors: Zhong
authors: Department of Nuclear Medicine, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, 160 Pujian Road, Shanghai, 200127, China. shaoli-song@163.com.
authors: Shaoli
authors: S
authors: Song
mesh_terms: D000203:Activities of Daily Living; D000328:Adult; D000368:Aged; D000674:Amputees / Q000534:rehabilitation*; D001186:Artificial Limbs; D001676:Biofeedback, Psychology; D001921:Brain / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D002560:Cerebrovascular Circulation; D004576:Electromyography; D001330:Electronic Data Processing; D005260:Female; D006225:Hand; D006801:Humans; D008297:Male; D008875:Middle Aged; D009473:Neuronal Plasticity; D000072098:Single Photon Emission Computed Tomography Computed Tomography / Q000379:methods; D016896:Treatment Outcome
keywords: Cerebral blood flow; Computed-aided method; Myoelectric hand; Rehabilitation; SPECT/CT