title: Integrating Inflammasome Signaling in Sexually Transmitted Infections.
abstract: Inflammasomes are cytosolic multiprotein platforms with pivotal roles in infectious diseases. Activation of inflammasomes results in proinflammatory cytokine signaling and pyroptosis. Sexually transmitted infections (STIs) are a major health problem worldwide, yet few studies have probed the impact of inflammasome signaling during these infections. Due to the dearth of appropriate infection models, our current understanding of inflammasomes in STIs is mostly drawn from results obtained in vitro, from distant infection sites, or from related microbial strains that are not sexually transmitted. Understanding how inflammasomes influence the outcome of STIs may lead to the development of novel and effective strategies to control disease and prevent transmission. Here we discuss and highlight the recent progress in this field.
authors: Department of Biology, Missouri State University, Springfield, MO 65809, USA.
authors: Christopher
authors: C
authors: Lupfer
authors: Infectious Diseases and Immunity, Imperial College London, London W12 0NN, UK. Electronic address: paras.anand@imperial.ac.uk.
authors: Paras K
authors: PK
authors: Anand
mesh_terms: D000818:Animals; D017209:Apoptosis; D016207:Cytokines / Q000378:metabolism; D004195:Disease Models, Animal; D006801:Humans; D017053:Infection Control; D058847:Inflammasomes / Q000378:metabolism*; D018836:Inflammation Mediators / Q000378:metabolism; D012749:Sexually Transmitted Diseases / Q000276:immunology* / Q000635:transmission; D015398:Signal Transduction
chemical_list: D016207:Cytokines; D058847:Inflammasomes; D018836:Inflammation Mediators
keywords: AIM2; IFI16; IL-18; IL-1β; NLRC4; NLRP3; cancer; caspase-1; immunopathology; inflammasome; inflammation; oncogenic; sexually transmitted infections; tumor