title: Monitoring of L-Arginine and Endogenous Dimethylarginines in Survivor Septic Patients - A Pilot Study.
abstract: OBJECTIVE
  Nitric oxide (NO) pathway plays a major role in the development and advancement of inflammation. We aimed to design a study and investigate its feasibility to show the changes of L-arginine, asymmetric dimethylarginine (ADMA) and symmetric dimethylarginine (SDMA), which are important regulators of the NO pathway.
  
  
  METHODS
  Concentrations of L-arginine, ADMA and SDMA were measured by liquid chromatography-tandem mass spectrometry. Seventeen septic survival patients were enrolled and blood samples were obtained on the first, third and fifth day after the diagnosis of sepsis. Sixteen non-septic matched controls were recruited.
  
  
  RESULTS
  ADMA levels on admission correlated well with sequential organ failure assessment (SOFA) score. During the follow-up, L-arginine/ADMA ratio increased significantly from day 1 to day 3 (p=0.005), then decreased from day 3 to day 5 (p=0.023).
  
  
  CONCLUSIONS
  This study design seems feasible to investigate changes of L-Arginine, ADMA and SDMA in sepsis survival patients.
authors: Department of Public Health Medicine, Medical School, University of Pécs, Pécs, Hungary Zsigmondy Vilmos SPA Hospital, Harkány, Hungary balazs.nemeth@aok.pte.hu.
authors: Balázs
authors: B
authors: Németh
authors: Department of Public Health Medicine, Medical School, University of Pécs, Pécs, Hungary.
authors: István
authors: I
authors: Kiss
authors: Zsigmondy Vilmos SPA Hospital, Harkány, Hungary.
authors: Iván
authors: I
authors: Péter
authors: Zsigmondy Vilmos SPA Hospital, Harkány, Hungary Heart Institute, Medical School, University of Pécs, Pécs, Hungary.
authors: Zénó
authors: Z
authors: Ajtay
authors: Heart Institute, Medical School, University of Pécs, Pécs, Hungary.
authors: Ádám
authors: Á
authors: Németh
authors: Department of Biochemistry and Medical Chemistry, Medical School, University of Pécs, Pécs, Hungary.
authors: László
authors: L
authors: Márk
authors: Department of Biochemistry and Medical Chemistry, Medical School, University of Pécs, Pécs, Hungary Department of Pharmacognosy, Faculty of Pharmacy, University of Szeged, Szeged, Hungary.
authors: Attila
authors: A
authors: Csorba
authors: Department of Laboratory Medicine, Medical School, University of Pécs, Pécs, Hungary János Szentágothai Research Centre, University of Pécs, Pécs, Hungary.
authors: Tamás
authors: T
authors: Kőszegi
authors: Department of Anaesthesiology and Intensive Therapy, Medical School, University of Pécs, Pécs, Hungary.
authors: Diána
authors: D
authors: Mühl
authors: Department of Laboratory Medicine, Medical School, University of Pécs, Pécs, Hungary János Szentágothai Research Centre, University of Pécs, Pécs, Hungary Department of Anaesthesiology and Intensive Therapy, Medical School, University of Pécs, Pécs, Hungary.
authors: Péter
authors: P
authors: Kustán
mesh_terms: D000368:Aged; D001120:Arginine / Q000031:analogs & derivatives* / Q000097:blood*; D002853:Chromatography, Liquid; D005260:Female; D006801:Humans; D007249:Inflammation / Q000097:blood / Q000473:pathology; D008297:Male; D053858:Metabolic Networks and Pathways; D008875:Middle Aged; D009569:Nitric Oxide / Q000097:blood; D018805:Sepsis / Q000097:blood* / Q000473:pathology; D053719:Tandem Mass Spectrometry
chemical_list: D009569:Nitric Oxide; C024917:symmetric dimethylarginine; C018524:N,N-dimethylarginine; D001120:Arginine
keywords: L-arginine; Sepsis; asymmetric dimethylarginine; nitric oxide; survival