title: The structure proposed for apteniol D is different from that of the compound obtained by total synthesis.
abstract: We describe the synthesis of 4,4'-oxyneolignan, the proposed structure for naturally occurring apteniol D. The diphenyl ether moiety in 4,4'-oxyneolignan was formed via classical Ullmann ether synthesis using excess copper powder in N,N-dimethylacetamide. The spectral data of synthesised apteniol D show differences compared to those of naturally occurring apteniol D.
authors: a Faculty of Life and Environmental Sciences, Department of Life Sciences , Prefectural University of Hiroshima , Shobara , Japan.
authors: Toshiro
authors: T
authors: Noshita
authors: a Faculty of Life and Environmental Sciences, Department of Life Sciences , Prefectural University of Hiroshima , Shobara , Japan.
authors: Kohei
authors: K
authors: Matsumoto
authors: a Faculty of Life and Environmental Sciences, Department of Life Sciences , Prefectural University of Hiroshima , Shobara , Japan.
authors: Hikaru
authors: H
authors: Nishikawa
authors: b Faculty of Pharmaceutical Education, Department of Pharmacy , Kinki University , Higashiosaka , Japan.
authors: Hidekazu
authors: H
authors: Ouchi
authors: c Graduate School of Engineering , Osaka Electro-Communication University , Neyagawa , Japan.
authors: Yoshitomo
authors: Y
authors: Hamada
authors: c Graduate School of Engineering , Osaka Electro-Communication University , Neyagawa , Japan.
authors: Akiko
authors: A
authors: Saito
authors: d Department of Bioscience and Biotechnology for Future Bioindustry, Graduate School of Agricultural Science , Tohoku University , Sendai , Japan.
authors: Teiko
authors: T
authors: Yamada
mesh_terms: D035722:Aizoaceae / Q000737:chemistry; D004987:Ethers / Q000737:chemistry; D006863:Hydrogen-Ion Concentration; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D010647:Phenyl Ethers / Q000737:chemistry*; D013055:Spectrophotometry, Infrared
chemical_list: D004987:Ethers; D010647:Phenyl Ethers; C000617918:apteniol D
keywords: Aptenia cordifolia; Ullmann ether synthesis; apteniol; diphenyl ether