title: Perioperative Predictors of Survival After Liver Transplantation for Familial Amyloid Polyneuropathy in a Portuguese Center.
abstract: BACKGROUND
  Liver transplantation (LT) has been the treatment of choice to halt the progression of familial amyloid polyneuropathy (FAP). Few studies have identified prognostic factors for post-LT survival in FAP. Our aim was to assess survival rate and to identify independent factors for survival after LT.
  
  
  METHODS
  This retrospective cohort study of FAP patients transplanted for the first time analyzed 116 transplantations from 2006 to 2014. The median follow-up period was 45.5 months.
  
  
  RESULTS
  The overall survival rates at 1 month, 1 year, and 5 years were 89%, 82% and 79%, respectively. On multivariate analysis, only number of red blood cell (RBC) units transfused during surgery, operation time, and body mass index were independent prognostic factors for patient survival. Only 30% of patients were transfused during surgery, and, in these, each RBC unit transfused increased mortality by 53%. The operation time increased mortality by 20% for every 15 minutes of surgery.
  
  
  CONCLUSIONS
  This study suggests that operation time and RBC transfused are predominant factors affecting post-LT survival in our FAP patients.
authors: Department of Anesthesiology, Intensive Care, and Emergency, Centro Hospitalar do Porto, Porto, Portugal. Electronic address: firlagarto@gmail.com.
authors: F
authors: F
authors: Lagarto
authors: Department of Anesthesiology, Intensive Care, and Emergency, Centro Hospitalar do Porto, Porto, Portugal.
authors: B
authors: B
authors: Gomes
authors: Department of Anesthesiology, Intensive Care, and Emergency, Centro Hospitalar do Porto, Porto, Portugal.
authors: P Sá
authors: PS
authors: Couto
authors: Department of Anesthesiology, Intensive Care, and Emergency, Centro Hospitalar do Porto, Porto, Portugal.
authors: F
authors: F
authors: Correia de Barros
authors: Department of Anesthesiology, Intensive Care, and Emergency, Centro Hospitalar do Porto, Porto, Portugal.
authors: Z
authors: Z
authors: Moreira
authors: Department of Anesthesiology, Intensive Care, and Emergency, Centro Hospitalar do Porto, Porto, Portugal.
authors: T
authors: T
authors: Branco
authors: Department of Anesthesiology, Intensive Care, and Emergency, Centro Hospitalar do Porto, Porto, Portugal.
authors: L
authors: L
authors: Fonseca
authors: Department of Anesthesiology, Intensive Care, and Emergency, Centro Hospitalar do Porto, Porto, Portugal.
authors: J
authors: J
authors: Aguiar
authors: Department of Anesthesiology, Intensive Care, and Emergency, Centro Hospitalar do Porto, Porto, Portugal.
authors: I
authors: I
authors: Aragão
authors: Department of Liver Transplantation, Centro Hospitalar do Porto, Porto, Portugal.
authors: H P
authors: HP
authors: Miranda
authors: Department of Liver Transplantation, Centro Hospitalar do Porto, Porto, Portugal.
authors: J
authors: J
authors: Daniel
authors: Department of Anesthesiology, Intensive Care, and Emergency, Centro Hospitalar do Porto, Porto, Portugal; Department of Liver Transplantation, Centro Hospitalar do Porto, Porto, Portugal.
authors: S
authors: S
authors: Esteves
mesh_terms: D000328:Adult; D028227:Amyloid Neuropathies, Familial / Q000401:mortality*; D018450:Disease Progression; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D053208:Kaplan-Meier Estimate; D016031:Liver Transplantation / Q000401:mortality*; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D061646:Operative Time; D011174:Portugal / Q000453:epidemiology; D012189:Retrospective Studies; D015996:Survival Rate