title: Recurrent Aortic Dissection: Observations From the International Registry of Aortic Dissection.
abstract: Improved medical care after initial aortic dissection (AD) has led to increased survivorship and a population of individuals at risk for further cardiovascular events, including recurrent AD. Reports describing recurrent ADs have been restricted to small numbers of patients from single institutions. We used the IRAD (International Registry of Acute Aortic Dissection) database to examine the clinical profiles and outcomes of patients with recurrent AD.
  
  
  
  We identified 204 patients enrolled in IRAD with recurrent AD. For the primary analysis, patient characteristics, interventions, and outcomes were analyzed and compared with 3624 patients with initial AD. Iterative logistic modeling was performed to investigate variables associated with recurrent AD. Cox regression analyses were used to determine variables associated with 5-year survival. A subset of recurrent AD patients was analyzed for anatomic and demographic details of initial and recurrent ADs.
  
  
  
  Patients with recurrent AD were more likely to have Marfan syndrome (21.5% versus 3.1%; P<0.001) but not bicuspid aortic valve (3.6% versus 3.2%; P=0.77). Descending aortic dimensions were greater in patients with recurrent AD than in patients with initial AD independently of sentinel dissection type (type A: 4.3 cm [3.5-5.6 cm] versus 3.3 cm [2.9-3.7 cm], P<0.001; type B: 5.0 cm [3.9-6.0 cm] versus 4.0 cm [3.5-4.8 cm], P<0.001), and this observation was accentuated among patients with Marfan syndrome. In multivariate analysis, the diagnosis of Marfan syndrome independently predicted recurrent AD (hazard ratio, 8.6; 95% confidence interval, 5.8-12.8; P<0.001). Patients with recurrent AD who presented with proximal followed by distal AD were younger than patients who experienced distal followed by proximal dissection AD (42.1±16.1 versus 54.3±14.8 years; P=0.004).
  
  
  
  Among those suffering acute aortic dissection, 5% have a history of a prior aortic dissection. Recurrent AD is strongly associated with Marfan syndrome.
authors: From Thoracic Aortic Center (E.M.I., M.A., M.E.L.), Cardiology Division, Department of Medicine (E.M.I., M.E.L.), Cardiovascular Research Center (M.A., M.E.L.), and Pediatric Cardiology Division, Department of Pediatrics (M.E.L.), Massachusetts General Hospital and Harvard Medical School, Boston, MA; Brigham and Women's Hospital, Cardiology Division, Boston, MA (M.P.B.); Cardiac Surgery Department, University Hospital S. Orsola, Bologna, Italy (M.D.E.); Cardiovascular Center (J.F., D.M., K.E.) and Cardiac Surgery (H.P.), University of Michigan, Ann Arbor; Cardiology Division, University of Salerno, Salerno, Italy (E.B.); Department of Cardiology, Robert Bosch Hospital, Stuttgart, Germany (U.S.); Departments of Medicine and Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia (R.P.); Division of Cardiothoracic Surgery, Cedars-Sinai Med Center, Los Angeles, CA (A.K.); Department of Vascular and Endovascular Surgery, Klinikum rechts der Isar, Technical University Munich, Munich, Germany (H.-H.E.); Hopital Bichat, Université Paris, Paris, France (G.J.); Department of Cardiothoracic Surgery, Royal Prince Alfred Hospital, Sydney, Australia (F.R.); and Royal Brompton & Harefield NHS Trust, Cardiology and Aortic Centre, London, UK (C.A.N.).
authors: Eric M
authors: EM
authors: Isselbacher
authors: From Thoracic Aortic Center (E.M.I., M.A., M.E.L.), Cardiology Division, Department of Medicine (E.M.I., M.E.L.), Cardiovascular Research Center (M.A., M.E.L.), and Pediatric Cardiology Division, Department of Pediatrics (M.E.L.), Massachusetts General Hospital and Harvard Medical School, Boston, MA; Brigham and Women's Hospital, Cardiology Division, Boston, MA (M.P.B.); Cardiac Surgery Department, University Hospital S. Orsola, Bologna, Italy (M.D.E.); Cardiovascular Center (J.F., D.M., K.E.) and Cardiac Surgery (H.P.), University of Michigan, Ann Arbor; Cardiology Division, University of Salerno, Salerno, Italy (E.B.); Department of Cardiology, Robert Bosch Hospital, Stuttgart, Germany (U.S.); Departments of Medicine and Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia (R.P.); Division of Cardiothoracic Surgery, Cedars-Sinai Med Center, Los Angeles, CA (A.K.); Department of Vascular and Endovascular Surgery, Klinikum rechts der Isar, Technical University Munich, Munich, Germany (H.-H.E.); Hopital Bichat, Université Paris, Paris, France (G.J.); Department of Cardiothoracic Surgery, Royal Prince Alfred Hospital, Sydney, Australia (F.R.); and Royal Brompton & Harefield NHS Trust, Cardiology and Aortic Centre, London, UK (C.A.N.).
authors: Marc P
authors: MP
authors: Bonaca
authors: From Thoracic Aortic Center (E.M.I., M.A., M.E.L.), Cardiology Division, Department of Medicine (E.M.I., M.E.L.), Cardiovascular Research Center (M.A., M.E.L.), and Pediatric Cardiology Division, Department of Pediatrics (M.E.L.), Massachusetts General Hospital and Harvard Medical School, Boston, MA; Brigham and Women's Hospital, Cardiology Division, Boston, MA (M.P.B.); Cardiac Surgery Department, University Hospital S. Orsola, Bologna, Italy (M.D.E.); Cardiovascular Center (J.F., D.M., K.E.) and Cardiac Surgery (H.P.), University of Michigan, Ann Arbor; Cardiology Division, University of Salerno, Salerno, Italy (E.B.); Department of Cardiology, Robert Bosch Hospital, Stuttgart, Germany (U.S.); Departments of Medicine and Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia (R.P.); Division of Cardiothoracic Surgery, Cedars-Sinai Med Center, Los Angeles, CA (A.K.); Department of Vascular and Endovascular Surgery, Klinikum rechts der Isar, Technical University Munich, Munich, Germany (H.-H.E.); Hopital Bichat, Université Paris, Paris, France (G.J.); Department of Cardiothoracic Surgery, Royal Prince Alfred Hospital, Sydney, Australia (F.R.); and Royal Brompton & Harefield NHS Trust, Cardiology and Aortic Centre, London, UK (C.A.N.).
authors: Marco
authors: M
authors: Di Eusanio
authors: From Thoracic Aortic Center (E.M.I., M.A., M.E.L.), Cardiology Division, Department of Medicine (E.M.I., M.E.L.), Cardiovascular Research Center (M.A., M.E.L.), and Pediatric Cardiology Division, Department of Pediatrics (M.E.L.), Massachusetts General Hospital and Harvard Medical School, Boston, MA; Brigham and Women's Hospital, Cardiology Division, Boston, MA (M.P.B.); Cardiac Surgery Department, University Hospital S. Orsola, Bologna, Italy (M.D.E.); Cardiovascular Center (J.F., D.M., K.E.) and Cardiac Surgery (H.P.), University of Michigan, Ann Arbor; Cardiology Division, University of Salerno, Salerno, Italy (E.B.); Department of Cardiology, Robert Bosch Hospital, Stuttgart, Germany (U.S.); Departments of Medicine and Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia (R.P.); Division of Cardiothoracic Surgery, Cedars-Sinai Med Center, Los Angeles, CA (A.K.); Department of Vascular and Endovascular Surgery, Klinikum rechts der Isar, Technical University Munich, Munich, Germany (H.-H.E.); Hopital Bichat, Université Paris, Paris, France (G.J.); Department of Cardiothoracic Surgery, Royal Prince Alfred Hospital, Sydney, Australia (F.R.); and Royal Brompton & Harefield NHS Trust, Cardiology and Aortic Centre, London, UK (C.A.N.).
authors: James
authors: J
authors: Froehlich
authors: From Thoracic Aortic Center (E.M.I., M.A., M.E.L.), Cardiology Division, Department of Medicine (E.M.I., M.E.L.), Cardiovascular Research Center (M.A., M.E.L.), and Pediatric Cardiology Division, Department of Pediatrics (M.E.L.), Massachusetts General Hospital and Harvard Medical School, Boston, MA; Brigham and Women's Hospital, Cardiology Division, Boston, MA (M.P.B.); Cardiac Surgery Department, University Hospital S. Orsola, Bologna, Italy (M.D.E.); Cardiovascular Center (J.F., D.M., K.E.) and Cardiac Surgery (H.P.), University of Michigan, Ann Arbor; Cardiology Division, University of Salerno, Salerno, Italy (E.B.); Department of Cardiology, Robert Bosch Hospital, Stuttgart, Germany (U.S.); Departments of Medicine and Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia (R.P.); Division of Cardiothoracic Surgery, Cedars-Sinai Med Center, Los Angeles, CA (A.K.); Department of Vascular and Endovascular Surgery, Klinikum rechts der Isar, Technical University Munich, Munich, Germany (H.-H.E.); Hopital Bichat, Université Paris, Paris, France (G.J.); Department of Cardiothoracic Surgery, Royal Prince Alfred Hospital, Sydney, Australia (F.R.); and Royal Brompton & Harefield NHS Trust, Cardiology and Aortic Centre, London, UK (C.A.N.).
authors: Eduardo
authors: E
authors: Bossone
authors: From Thoracic Aortic Center (E.M.I., M.A., M.E.L.), Cardiology Division, Department of Medicine (E.M.I., M.E.L.), Cardiovascular Research Center (M.A., M.E.L.), and Pediatric Cardiology Division, Department of Pediatrics (M.E.L.), Massachusetts General Hospital and Harvard Medical School, Boston, MA; Brigham and Women's Hospital, Cardiology Division, Boston, MA (M.P.B.); Cardiac Surgery Department, University Hospital S. Orsola, Bologna, Italy (M.D.E.); Cardiovascular Center (J.F., D.M., K.E.) and Cardiac Surgery (H.P.), University of Michigan, Ann Arbor; Cardiology Division, University of Salerno, Salerno, Italy (E.B.); Department of Cardiology, Robert Bosch Hospital, Stuttgart, Germany (U.S.); Departments of Medicine and Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia (R.P.); Division of Cardiothoracic Surgery, Cedars-Sinai Med Center, Los Angeles, CA (A.K.); Department of Vascular and Endovascular Surgery, Klinikum rechts der Isar, Technical University Munich, Munich, Germany (H.-H.E.); Hopital Bichat, Université Paris, Paris, France (G.J.); Department of Cardiothoracic Surgery, Royal Prince Alfred Hospital, Sydney, Australia (F.R.); and Royal Brompton & Harefield NHS Trust, Cardiology and Aortic Centre, London, UK (C.A.N.).
authors: Udo
authors: U
authors: Sechtem
authors: From Thoracic Aortic Center (E.M.I., M.A., M.E.L.), Cardiology Division, Department of Medicine (E.M.I., M.E.L.), Cardiovascular Research Center (M.A., M.E.L.), and Pediatric Cardiology Division, Department of Pediatrics (M.E.L.), Massachusetts General Hospital and Harvard Medical School, Boston, MA; Brigham and Women's Hospital, Cardiology Division, Boston, MA (M.P.B.); Cardiac Surgery Department, University Hospital S. Orsola, Bologna, Italy (M.D.E.); Cardiovascular Center (J.F., D.M., K.E.) and Cardiac Surgery (H.P.), University of Michigan, Ann Arbor; Cardiology Division, University of Salerno, Salerno, Italy (E.B.); Department of Cardiology, Robert Bosch Hospital, Stuttgart, Germany (U.S.); Departments of Medicine and Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia (R.P.); Division of Cardiothoracic Surgery, Cedars-Sinai Med Center, Los Angeles, CA (A.K.); Department of Vascular and Endovascular Surgery, Klinikum rechts der Isar, Technical University Munich, Munich, Germany (H.-H.E.); Hopital Bichat, Université Paris, Paris, France (G.J.); Department of Cardiothoracic Surgery, Royal Prince Alfred Hospital, Sydney, Australia (F.R.); and Royal Brompton & Harefield NHS Trust, Cardiology and Aortic Centre, London, UK (C.A.N.).
authors: Reed
authors: R
authors: Pyeritz
authors: From Thoracic Aortic Center (E.M.I., M.A., M.E.L.), Cardiology Division, Department of Medicine (E.M.I., M.E.L.), Cardiovascular Research Center (M.A., M.E.L.), and Pediatric Cardiology Division, Department of Pediatrics (M.E.L.), Massachusetts General Hospital and Harvard Medical School, Boston, MA; Brigham and Women's Hospital, Cardiology Division, Boston, MA (M.P.B.); Cardiac Surgery Department, University Hospital S. Orsola, Bologna, Italy (M.D.E.); Cardiovascular Center (J.F., D.M., K.E.) and Cardiac Surgery (H.P.), University of Michigan, Ann Arbor; Cardiology Division, University of Salerno, Salerno, Italy (E.B.); Department of Cardiology, Robert Bosch Hospital, Stuttgart, Germany (U.S.); Departments of Medicine and Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia (R.P.); Division of Cardiothoracic Surgery, Cedars-Sinai Med Center, Los Angeles, CA (A.K.); Department of Vascular and Endovascular Surgery, Klinikum rechts der Isar, Technical University Munich, Munich, Germany (H.-H.E.); Hopital Bichat, Université Paris, Paris, France (G.J.); Department of Cardiothoracic Surgery, Royal Prince Alfred Hospital, Sydney, Australia (F.R.); and Royal Brompton & Harefield NHS Trust, Cardiology and Aortic Centre, London, UK (C.A.N.).
authors: Himanshu
authors: H
authors: Patel
authors: From Thoracic Aortic Center (E.M.I., M.A., M.E.L.), Cardiology Division, Department of Medicine (E.M.I., M.E.L.), Cardiovascular Research Center (M.A., M.E.L.), and Pediatric Cardiology Division, Department of Pediatrics (M.E.L.), Massachusetts General Hospital and Harvard Medical School, Boston, MA; Brigham and Women's Hospital, Cardiology Division, Boston, MA (M.P.B.); Cardiac Surgery Department, University Hospital S. Orsola, Bologna, Italy (M.D.E.); Cardiovascular Center (J.F., D.M., K.E.) and Cardiac Surgery (H.P.), University of Michigan, Ann Arbor; Cardiology Division, University of Salerno, Salerno, Italy (E.B.); Department of Cardiology, Robert Bosch Hospital, Stuttgart, Germany (U.S.); Departments of Medicine and Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia (R.P.); Division of Cardiothoracic Surgery, Cedars-Sinai Med Center, Los Angeles, CA (A.K.); Department of Vascular and Endovascular Surgery, Klinikum rechts der Isar, Technical University Munich, Munich, Germany (H.-H.E.); Hopital Bichat, Université Paris, Paris, France (G.J.); Department of Cardiothoracic Surgery, Royal Prince Alfred Hospital, Sydney, Australia (F.R.); and Royal Brompton & Harefield NHS Trust, Cardiology and Aortic Centre, London, UK (C.A.N.).
authors: Ali
authors: A
authors: Khoynezhad
authors: From Thoracic Aortic Center (E.M.I., M.A., M.E.L.), Cardiology Division, Department of Medicine (E.M.I., M.E.L.), Cardiovascular Research Center (M.A., M.E.L.), and Pediatric Cardiology Division, Department of Pediatrics (M.E.L.), Massachusetts General Hospital and Harvard Medical School, Boston, MA; Brigham and Women's Hospital, Cardiology Division, Boston, MA (M.P.B.); Cardiac Surgery Department, University Hospital S. Orsola, Bologna, Italy (M.D.E.); Cardiovascular Center (J.F., D.M., K.E.) and Cardiac Surgery (H.P.), University of Michigan, Ann Arbor; Cardiology Division, University of Salerno, Salerno, Italy (E.B.); Department of Cardiology, Robert Bosch Hospital, Stuttgart, Germany (U.S.); Departments of Medicine and Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia (R.P.); Division of Cardiothoracic Surgery, Cedars-Sinai Med Center, Los Angeles, CA (A.K.); Department of Vascular and Endovascular Surgery, Klinikum rechts der Isar, Technical University Munich, Munich, Germany (H.-H.E.); Hopital Bichat, Université Paris, Paris, France (G.J.); Department of Cardiothoracic Surgery, Royal Prince Alfred Hospital, Sydney, Australia (F.R.); and Royal Brompton & Harefield NHS Trust, Cardiology and Aortic Centre, London, UK (C.A.N.).
authors: Hans-Henning
authors: HH
authors: Eckstein
authors: From Thoracic Aortic Center (E.M.I., M.A., M.E.L.), Cardiology Division, Department of Medicine (E.M.I., M.E.L.), Cardiovascular Research Center (M.A., M.E.L.), and Pediatric Cardiology Division, Department of Pediatrics (M.E.L.), Massachusetts General Hospital and Harvard Medical School, Boston, MA; Brigham and Women's Hospital, Cardiology Division, Boston, MA (M.P.B.); Cardiac Surgery Department, University Hospital S. Orsola, Bologna, Italy (M.D.E.); Cardiovascular Center (J.F., D.M., K.E.) and Cardiac Surgery (H.P.), University of Michigan, Ann Arbor; Cardiology Division, University of Salerno, Salerno, Italy (E.B.); Department of Cardiology, Robert Bosch Hospital, Stuttgart, Germany (U.S.); Departments of Medicine and Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia (R.P.); Division of Cardiothoracic Surgery, Cedars-Sinai Med Center, Los Angeles, CA (A.K.); Department of Vascular and Endovascular Surgery, Klinikum rechts der Isar, Technical University Munich, Munich, Germany (H.-H.E.); Hopital Bichat, Université Paris, Paris, France (G.J.); Department of Cardiothoracic Surgery, Royal Prince Alfred Hospital, Sydney, Australia (F.R.); and Royal Brompton & Harefield NHS Trust, Cardiology and Aortic Centre, London, UK (C.A.N.).
authors: Guillaume
authors: G
authors: Jondeau
authors: From Thoracic Aortic Center (E.M.I., M.A., M.E.L.), Cardiology Division, Department of Medicine (E.M.I., M.E.L.), Cardiovascular Research Center (M.A., M.E.L.), and Pediatric Cardiology Division, Department of Pediatrics (M.E.L.), Massachusetts General Hospital and Harvard Medical School, Boston, MA; Brigham and Women's Hospital, Cardiology Division, Boston, MA (M.P.B.); Cardiac Surgery Department, University Hospital S. Orsola, Bologna, Italy (M.D.E.); Cardiovascular Center (J.F., D.M., K.E.) and Cardiac Surgery (H.P.), University of Michigan, Ann Arbor; Cardiology Division, University of Salerno, Salerno, Italy (E.B.); Department of Cardiology, Robert Bosch Hospital, Stuttgart, Germany (U.S.); Departments of Medicine and Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia (R.P.); Division of Cardiothoracic Surgery, Cedars-Sinai Med Center, Los Angeles, CA (A.K.); Department of Vascular and Endovascular Surgery, Klinikum rechts der Isar, Technical University Munich, Munich, Germany (H.-H.E.); Hopital Bichat, Université Paris, Paris, France (G.J.); Department of Cardiothoracic Surgery, Royal Prince Alfred Hospital, Sydney, Australia (F.R.); and Royal Brompton & Harefield NHS Trust, Cardiology and Aortic Centre, London, UK (C.A.N.).
authors: Fabio
authors: F
authors: Ramponi
authors: From Thoracic Aortic Center (E.M.I., M.A., M.E.L.), Cardiology Division, Department of Medicine (E.M.I., M.E.L.), Cardiovascular Research Center (M.A., M.E.L.), and Pediatric Cardiology Division, Department of Pediatrics (M.E.L.), Massachusetts General Hospital and Harvard Medical School, Boston, MA; Brigham and Women's Hospital, Cardiology Division, Boston, MA (M.P.B.); Cardiac Surgery Department, University Hospital S. Orsola, Bologna, Italy (M.D.E.); Cardiovascular Center (J.F., D.M., K.E.) and Cardiac Surgery (H.P.), University of Michigan, Ann Arbor; Cardiology Division, University of Salerno, Salerno, Italy (E.B.); Department of Cardiology, Robert Bosch Hospital, Stuttgart, Germany (U.S.); Departments of Medicine and Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia (R.P.); Division of Cardiothoracic Surgery, Cedars-Sinai Med Center, Los Angeles, CA (A.K.); Department of Vascular and Endovascular Surgery, Klinikum rechts der Isar, Technical University Munich, Munich, Germany (H.-H.E.); Hopital Bichat, Université Paris, Paris, France (G.J.); Department of Cardiothoracic Surgery, Royal Prince Alfred Hospital, Sydney, Australia (F.R.); and Royal Brompton & Harefield NHS Trust, Cardiology and Aortic Centre, London, UK (C.A.N.).
authors: Mohammad
authors: M
authors: Abbasi
authors: From Thoracic Aortic Center (E.M.I., M.A., M.E.L.), Cardiology Division, Department of Medicine (E.M.I., M.E.L.), Cardiovascular Research Center (M.A., M.E.L.), and Pediatric Cardiology Division, Department of Pediatrics (M.E.L.), Massachusetts General Hospital and Harvard Medical School, Boston, MA; Brigham and Women's Hospital, Cardiology Division, Boston, MA (M.P.B.); Cardiac Surgery Department, University Hospital S. Orsola, Bologna, Italy (M.D.E.); Cardiovascular Center (J.F., D.M., K.E.) and Cardiac Surgery (H.P.), University of Michigan, Ann Arbor; Cardiology Division, University of Salerno, Salerno, Italy (E.B.); Department of Cardiology, Robert Bosch Hospital, Stuttgart, Germany (U.S.); Departments of Medicine and Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia (R.P.); Division of Cardiothoracic Surgery, Cedars-Sinai Med Center, Los Angeles, CA (A.K.); Department of Vascular and Endovascular Surgery, Klinikum rechts der Isar, Technical University Munich, Munich, Germany (H.-H.E.); Hopital Bichat, Université Paris, Paris, France (G.J.); Department of Cardiothoracic Surgery, Royal Prince Alfred Hospital, Sydney, Australia (F.R.); and Royal Brompton & Harefield NHS Trust, Cardiology and Aortic Centre, London, UK (C.A.N.).
authors: Daniel
authors: D
authors: Montgomery
authors: From Thoracic Aortic Center (E.M.I., M.A., M.E.L.), Cardiology Division, Department of Medicine (E.M.I., M.E.L.), Cardiovascular Research Center (M.A., M.E.L.), and Pediatric Cardiology Division, Department of Pediatrics (M.E.L.), Massachusetts General Hospital and Harvard Medical School, Boston, MA; Brigham and Women's Hospital, Cardiology Division, Boston, MA (M.P.B.); Cardiac Surgery Department, University Hospital S. Orsola, Bologna, Italy (M.D.E.); Cardiovascular Center (J.F., D.M., K.E.) and Cardiac Surgery (H.P.), University of Michigan, Ann Arbor; Cardiology Division, University of Salerno, Salerno, Italy (E.B.); Department of Cardiology, Robert Bosch Hospital, Stuttgart, Germany (U.S.); Departments of Medicine and Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia (R.P.); Division of Cardiothoracic Surgery, Cedars-Sinai Med Center, Los Angeles, CA (A.K.); Department of Vascular and Endovascular Surgery, Klinikum rechts der Isar, Technical University Munich, Munich, Germany (H.-H.E.); Hopital Bichat, Université Paris, Paris, France (G.J.); Department of Cardiothoracic Surgery, Royal Prince Alfred Hospital, Sydney, Australia (F.R.); and Royal Brompton & Harefield NHS Trust, Cardiology and Aortic Centre, London, UK (C.A.N.).
authors: Christoph A
authors: CA
authors: Nienaber
authors: From Thoracic Aortic Center (E.M.I., M.A., M.E.L.), Cardiology Division, Department of Medicine (E.M.I., M.E.L.), Cardiovascular Research Center (M.A., M.E.L.), and Pediatric Cardiology Division, Department of Pediatrics (M.E.L.), Massachusetts General Hospital and Harvard Medical School, Boston, MA; Brigham and Women's Hospital, Cardiology Division, Boston, MA (M.P.B.); Cardiac Surgery Department, University Hospital S. Orsola, Bologna, Italy (M.D.E.); Cardiovascular Center (J.F., D.M., K.E.) and Cardiac Surgery (H.P.), University of Michigan, Ann Arbor; Cardiology Division, University of Salerno, Salerno, Italy (E.B.); Department of Cardiology, Robert Bosch Hospital, Stuttgart, Germany (U.S.); Departments of Medicine and Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia (R.P.); Division of Cardiothoracic Surgery, Cedars-Sinai Med Center, Los Angeles, CA (A.K.); Department of Vascular and Endovascular Surgery, Klinikum rechts der Isar, Technical University Munich, Munich, Germany (H.-H.E.); Hopital Bichat, Université Paris, Paris, France (G.J.); Department of Cardiothoracic Surgery, Royal Prince Alfred Hospital, Sydney, Australia (F.R.); and Royal Brompton & Harefield NHS Trust, Cardiology and Aortic Centre, London, UK (C.A.N.).
authors: Kim
authors: K
authors: Eagle
authors: From Thoracic Aortic Center (E.M.I., M.A., M.E.L.), Cardiology Division, Department of Medicine (E.M.I., M.E.L.), Cardiovascular Research Center (M.A., M.E.L.), and Pediatric Cardiology Division, Department of Pediatrics (M.E.L.), Massachusetts General Hospital and Harvard Medical School, Boston, MA; Brigham and Women's Hospital, Cardiology Division, Boston, MA (M.P.B.); Cardiac Surgery Department, University Hospital S. Orsola, Bologna, Italy (M.D.E.); Cardiovascular Center (J.F., D.M., K.E.) and Cardiac Surgery (H.P.), University of Michigan, Ann Arbor; Cardiology Division, University of Salerno, Salerno, Italy (E.B.); Department of Cardiology, Robert Bosch Hospital, Stuttgart, Germany (U.S.); Departments of Medicine and Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia (R.P.); Division of Cardiothoracic Surgery, Cedars-Sinai Med Center, Los Angeles, CA (A.K.); Department of Vascular and Endovascular Surgery, Klinikum rechts der Isar, Technical University Munich, Munich, Germany (H.-H.E.); Hopital Bichat, Université Paris, Paris, France (G.J.); Department of Cardiothoracic Surgery, Royal Prince Alfred Hospital, Sydney, Australia (F.R.); and Royal Brompton & Harefield NHS Trust, Cardiology and Aortic Centre, London, UK (C.A.N.). lindsay.mark@mgh.harvard.edu.
authors: Mark E
authors: ME
authors: Lindsay
mesh_terms: D000328:Adult; D000368:Aged; D000784:Aortic Dissection / Q000150:complications* / Q000175:diagnosis / Q000601:surgery*; D001014:Aortic Aneurysm / Q000150:complications* / Q000175:diagnosis / Q000601:surgery*; D001021:Aortic Valve / Q000601:surgery; D005260:Female; D017052:Hospital Mortality; D006801:Humans; D008297:Male; D008382:Marfan Syndrome / Q000150:complications / Q000601:surgery; D008875:Middle Aged; D012008:Recurrence; D012042:Registries / Q000706:statistics & numerical data; D012307:Risk Factors
keywords: Marfan syndrome; aorta; aortic aneurysm