title: Imino Transfer Hydrogenation Reductions.
abstract: This review contains a summary of recent developments in the transfer hydrogenation of C=N bonds, with a particularly focus on reports from within the last 10 years and asymmetric transformations. However, earlier work in the area is also discussed in order to provide context for the more recent results described. I focus strongly on the Ru/TsDPEN class of asymmetric transfer hydrogenation reactions originally reported by Noyori et al., together with examples of their applications, particularly to medically valuable target molecules. The recent developments in the area of highly active imine-reduction catalysts, notably those based on iridium, are also described in some detail. I discuss diastereoselective reduction methods as a route to the synthesis of chiral amines using transfer hydrogenation. The recent development of a methodology for positioning reduction complexes within chiral proteins, permitting the generation of asymmetric reduction products through a directed modification of the protein environment in a controlled manner, is also discussed.
authors: The Department of Chemistry, Warwick University, Coventry, CV4 7AL, UK. m.wills@warwick.ac.uk.
authors: Martin
authors: M
authors: Wills
mesh_terms: D000588:Amines; D002384:Catalysis; D006865:Hydrogenation; D007097:Imines / Q000737:chemistry*; D007098:Imino Acids; D007495:Iridium; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D000588:Amines; D007097:Imines; D007098:Imino Acids; D009942:Organometallic Compounds; D007495:Iridium
keywords: Amine; Asymmetric; Hydrogenation; Imine; Reduction; Transfer