title: Nutrigenomics of extra-virgin olive oil: A review.
abstract: Nutrigenomics data on the functional components of olive oil are still sparse, but rapidly increasing. Olive oil is the main source of fat and health-promoting component of the Mediterranean diet. Positive effects have been observed on genes involved in the pathobiology of most prevalent age- and lifestyle-related human conditions, such as cancer, cardiovascular disease and neurodegeneration. Other effects on health-promoting genes have been identified for bioactive components of olives and olive leafs. Omics technologies are offering unique opportunities to identify nutritional and health biomarkers associated with these gene responses, the use of which in personalized and even predictive protocols of investigation, is a main breakthrough in modern medicine and nutrition. Gene regulation properties of the functional components of olive oil, such as oleic acid, biophenols and vitamin E, point to a role for these molecules as natural homeostatic and even hormetic factors with applications as prevention agents in conditions of premature and pathologic aging. Therapeutic applications can be foreseen in conditions of chronic inflammation, and particularly in cancer, which will be discussed in detail in this review paper as major clinical target of nutritional interventions with olive oil and its functional components. © 2016 BioFactors, 43(1):17-41, 2017.
authors: Department of Pharmaceutical Sciences, Nutrition and Clinical Biochemistry Lab, University of Perugia, Italy.
authors: Marta
authors: M
authors: Piroddi
authors: IRCCS MultiMedica, Scientific and Technology Pole, Milan, Italy.
authors: Adriana
authors: A
authors: Albini
authors: Department of Chemistry, Biology and Biotechnologies, University of Perugia, Italy.
authors: Roberto
authors: R
authors: Fabiani
authors: NEUROFARBA - Section of Phamacology and Toxicology, University of Firenze, Italy.
authors: Lisa
authors: L
authors: Giovannelli
authors: NEUROFARBA - Section of Phamacology and Toxicology, University of Firenze, Italy.
authors: Cristina
authors: C
authors: Luceri
authors: CREA-NUT, Consiglio per La Ricerca in Agricoltura E L'Analisi Dell'Economia Agraria, Food and Nutrition Research Centre, via Ardeatina 546, 00178, Roma, Italy.
authors: Fausta
authors: F
authors: Natella
authors: Department of Chemistry, Biology and Biotechnologies, University of Perugia, Italy.
authors: Patrizia
authors: P
authors: Rosignoli
authors: Research and Statistics, Department, IRCCS "Tecnologie Avanzate E Modelli Assistenziali in Oncologia", Laboratory of Translational Research, Arcispedale S. Maria Nuova-IRCCS, Reggio Emilia, Italy.
authors: Teresa
authors: T
authors: Rossi
authors: Department of Agricultural Food and Environmental Sciences, University of Perugia, Italy.
authors: Agnese
authors: A
authors: Taticchi
authors: Department of Agricultural Food and Environmental Sciences, University of Perugia, Italy.
authors: Maurizio
authors: M
authors: Servili
authors: Department of Pharmaceutical Sciences, Nutrition and Clinical Biochemistry Lab, University of Perugia, Italy.
authors: Francesco
authors: F
authors: Galli
mesh_terms: D000375:Aging; D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology; D000975:Antioxidants / Q000494:pharmacology; D038441:Diet, Mediterranean; D044127:Epigenesis, Genetic; D015870:Gene Expression; D006801:Humans; D035683:MicroRNAs / Q000502:physiology; D054647:Nutrigenomics; D000069463:Olive Oil / Q000494:pharmacology*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D000975:Antioxidants; D035683:MicroRNAs; D000069463:Olive Oil
keywords: extravirgin olive oil; nutrigenomics; olive oil; polyphenols; vitamin E