title: Epidemiological and clinical characteristics of malignant melanoma in Southeast Anatolia in Turkey.
abstract: BACKGROUND
  The present study aimed to establish the epidemiological and clinical characteristics of patients who were histopathologically diagnosed with malignant melanoma (MM).
  
  
  METHODS
  The present study retrospectively analyzed the data of 78 patients who were histopathologically diagnosed with MM in Dicle University Medical Faculty, Dermatology and Medical Oncology departments between 2005 and 2014.
  
  
  RESULTS
  The study included 78 patients in total with 44 (56.4%) male and 34 (43.6%) female. Median age of the patients was 62.50 years (range: 27 - 84 years). Of the patients, 78.2% (n = 61) had cutaneous melanoma, 8.9% had solid organ melanoma, and 2.5% had ocular and mucosal melanoma. The most common tumor localization among the patients was the lower extremities with 29.4% (n = 23). The most common histopathological type was nodular malignant melanoma with 35.8% (n = 28). Based on TNM, Clark and Breslow classifications, 26.9% (n = 21) of the patients were stage 4, 26.9% (n = 21) were Clark stage 4, and 37.1% (n = 29) were Breslow stage 4. Median overall survival in all patients was 14.9 months (95% CI 10.9 - 18.8 months). In the multivariate Cox analysis, only stage statistically significantly affecting survival [odds ratio (OR): 0.54; (95% CI 0.16-1.82, p = 0.02)].
  
  
  CONCLUSIONS
  Malignant melanoma data are also important for the optimal utilization of effective methods and healthcare resources to prevent the disease. In order to minimize MM mortality and morbidity, not only the society but also physicians from primary and secondary care hospitals should become familiar with melanoma.
authors: Department of Dermatology, Faculty of Medicine, Dicle University, Diyarbakir, Turkey.
authors: Bilal
authors: B
authors: Sula
authors: Department of Gastroenterology, Faculty of Medicine, Dicle University, Diyarbakir, Turkey.
authors: Feyzullah
authors: F
authors: Uçmak
authors: Department of Medical Oncology, Faculty of Medicine, Dicle University, Diyarbakir, Turkey.
authors: Mehmet Ali
authors: MA
authors: Kaplan
authors: Department of Medical Oncology, Faculty of Medicine, Dicle University, Diyarbakir, Turkey.
authors: Zuhat
authors: Z
authors: Urakçi
authors: Department of Dermatology, Faculty of Medicine, Dicle University, Diyarbakir, Turkey.
authors: Mustafa
authors: M
authors: Arica
authors: Department of Medical Oncology, Faculty of Medicine, Dicle University, Diyarbakir, Turkey.
authors: Abdurrahman
authors: A
authors: Isikdogan
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D008297:Male; D008545:Melanoma / Q000453:epidemiology* / Q000473:pathology; D008875:Middle Aged; D015999:Multivariate Analysis; D016016:Proportional Hazards Models; D012189:Retrospective Studies; D012878:Skin Neoplasms / Q000453:epidemiology* / Q000473:pathology; D015996:Survival Rate; D014421:Turkey / Q000453:epidemiology
keywords: Malignant melanoma; clinic; epidemiology