title: Lack of association between SREBF-1c gene polymorphisms and risk of non-alcoholic fatty liver disease in a Chinese Han population.
abstract: The transcription factor sterol regulatory element-binding protein-1c (SREBP-1c) is a key regulator of lipogenesis and insulin sensitivity, and is associated with non-alcoholic fatty liver disease (NAFLD). Here, we assessed the impact of common single nucleotide polymorphisms (SNPs) in SREBF-1c on NAFLD susceptibility and associated metabolic phenotypes in a Han Chinese population. Four common SNPs (rs62064119, rs2297508, rs11868035 and rs13306741) in the SREBP-1c gene were selected and genotyped in 593 patients with NAFLD and 593 healthy controls. Unconditional logistic regression was performed to assess the risk of NAFLD by determining odds ratios and 95% confidence intervals (CIs). No significant differences in genotype and allele frequencies of these four SNPs were found between the NAFLD population and the controls (all P > 0.05). In addition, we did not find any association between the SREBF-1c SNPs and the clinical and biochemical parameters, such as body mass index, total cholesterol, high density lipoprotein-and low density lipoprotein-cholesterol or systolic and diastolic blood pressure, except that the rs2297508 C-allele or rs11868035 G-allele showed significant associations with lower triglyceride levels in control subjects (P < 0.01). Our findings suggested that the four polymorphisms in SREBF-1c gene are not associated with risk of NAFLD in the Chinese Han population.
authors: Department of Epidemiology and Health Statistics, the Key Laboratory of Environment and Health, universities and colleges in Fujian, School of Public Health, Fujian Medical University, 1 Xueyuan Road, Minhou, Fuzhou 350108, China.|Key Laboratory of Ministry of Education for Gastrointestinal Cancer, Fujian Medical University, 1 Xueyuan Road, Minhou, Fuzhou 350108, China.
authors: Xian-E
authors: XE
authors: Peng
authors: Department of Gastroenterology, Union Hospital of Fujian Medical University, 29 Xinquan Road, Fuzhou 35001, China.
authors: Feng-Lin
authors: FL
authors: Chen
authors: Department of Epidemiology and Health Statistics, the Key Laboratory of Environment and Health, universities and colleges in Fujian, School of Public Health, Fujian Medical University, 1 Xueyuan Road, Minhou, Fuzhou 350108, China.
authors: Wenjuan
authors: W
authors: Liu
authors: Department of Epidemiology and Health Statistics, the Key Laboratory of Environment and Health, universities and colleges in Fujian, School of Public Health, Fujian Medical University, 1 Xueyuan Road, Minhou, Fuzhou 350108, China.
authors: ZhiJian
authors: Z
authors: Hu
authors: Key Laboratory of Ministry of Education for Gastrointestinal Cancer, Fujian Medical University, 1 Xueyuan Road, Minhou, Fuzhou 350108, China.|Fujian Key Laboratory of Tumor Microbiology, Fujian Medical University, 1 Xueyuan Road, Minhou, Fuzhou 350108, China.
authors: Xu
authors: X
authors: Lin
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000410:Alanine Transaminase / Q000097:blood; D000483:Alleles; D044466:Asian People / Q000235:genetics*; D001219:Aspartate Aminotransferases / Q000097:blood; D016022:Case-Control Studies; D002681:China; D005006:Ethnicity / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D006801:Humans; D016015:Logistic Models; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood / Q000208:ethnology / Q000235:genetics; D008875:Middle Aged; D065626:Non-alcoholic Fatty Liver Disease / Q000201:enzymology / Q000208:ethnology / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D012306:Risk; D012959:Socioeconomic Factors; D051780:Sterol Regulatory Element Binding Protein 1 / Q000235:genetics*; D013662:Tea; D055815:Young Adult
chemical_list: C497387:SREBF1 protein, human; D051780:Sterol Regulatory Element Binding Protein 1; D013662:Tea; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase