title: Pharmacological Correction of Alcohol Motivation Depends on the Phenotype of the Response to Emotional Stress.
abstract: The specific features of alcohol behavior were studied in MR and MNRA rats that exhibit an opposite reaction to emotional stress. We evaluated the effect of a dipeptide anxiolytic GB-115 (N-phenyl-hexanoyl-glycyl-L-tryptophan amide, neuropeptide cholecystokinin-4 analogue with antagonistic activity) on alcohol motivation in rats, which was formed over 12 months. High-emotionality MR rats were more sensitive to the anxiolytic effect of ethanol in the conflict situation test than low-emotionality MNRA rats. MNRA rats consumed a greater amount of ethanol under a free-choice condition with 15% ethanol solution and water (as in comparison with MR rats). However, the behavior of MR rats was transformed due to a significant increase in alcohol motivation from the 5th month of long-term free access to ethanol. An anxiolytic GB-115 (0.025 mg/kg intraperitoneally for 14 days) with selective activity in high-emotionality rats was shown to reduce significantly the average daily consumption and alcohol-deprivation effect in MR rats, but did not modulate ethanol addiction in MNRA rats.
authors: V. V. Zakusov Research Institute of Pharmacology, Moscow, Russia. lgkoplik@mail.ru.
authors: L G
authors: LG
authors: Kolik
authors: V. V. Zakusov Research Institute of Pharmacology, Moscow, Russia.
authors: T A
authors: TA
authors: Gudasheva
authors: V. V. Zakusov Research Institute of Pharmacology, Moscow, Russia.
authors: V A
authors: VA
authors: Martyanov
authors: V. V. Zakusov Research Institute of Pharmacology, Moscow, Russia.
authors: S B
authors: SB
authors: Seredenin
mesh_terms: D000437:Alcoholism / Q000188:drug therapy / Q000523:psychology; D000818:Animals; D014151:Anti-Anxiety Agents / Q000627:therapeutic use; D001522:Behavior, Animal; D002755:Choice Behavior / Q000187:drug effects; D004151:Dipeptides / Q000627:therapeutic use; D000431:Ethanol; D008297:Male; D009042:Motivation / Q000187:drug effects; D051381:Rats; D013315:Stress, Psychological / Q000188:drug therapy*
chemical_list: D014151:Anti-Anxiety Agents; D004151:Dipeptides; C520797:GB-115; D000431:Ethanol
keywords: GB-115; MR and MNRA rats; anxiolytic; ethanol consumption