title: Chondroitin sulfate attenuates formalin-induced persistent tactile allodynia.
abstract: We examined the effect of chondroitin sulfate (CS), a compound used in the treatment of osteoarthritis and joint pain, on the formalin-induced tactile allodynia in mice. A repeated oral administration of CS (300 mg/kg, b.i.d.) significantly ameliorated the formalin-induced tactile allodynia from day 10 after formalin injection. On day 14, the phosphorylation of spinal p38 MAPK and subsequent increase in c-Fos-immunoreactive dorsal lumbar neurons were attenuated by the repeated administration of CS. These findings suggest that CS attenuates formalin-induced tactile allodynia through the inhibition of p38 MAPK phosphorylation and subsequent up-regulation of c-Fos expression in the dorsal lumbar spinal cord.
authors: Department of Pharmacology, Faculty of Pharmaceutical Sciences, Tohoku Medical and Pharmaceutical University, 4-4-1 Komatsushima, Aoba-ku, Sendai 981-8558, Japan.
authors: Wataru
authors: W
authors: Nemoto
authors: Consumer Healthcare Products Development, Zeria Pharmaceutical Co., Ltd., 10-11 Nihonbashi, Kobuna-cho, Chuo-ku, Tokyo 103-8351, Japan.
authors: Kotaro
authors: K
authors: Yamada
authors: Department of Pharmacology, Faculty of Pharmaceutical Sciences, Tohoku Medical and Pharmaceutical University, 4-4-1 Komatsushima, Aoba-ku, Sendai 981-8558, Japan.
authors: Yoshiki
authors: Y
authors: Ogata
authors: Department of Pharmacology, Faculty of Pharmaceutical Sciences, Tohoku Medical and Pharmaceutical University, 4-4-1 Komatsushima, Aoba-ku, Sendai 981-8558, Japan.
authors: Osamu
authors: O
authors: Nakagawasai
authors: Department of Pharmacology, Faculty of Pharmaceutical Sciences, Tohoku Medical and Pharmaceutical University, 4-4-1 Komatsushima, Aoba-ku, Sendai 981-8558, Japan.
authors: Katsuhito
authors: K
authors: Onodera
authors: Consumer Healthcare Products Development, Zeria Pharmaceutical Co., Ltd., 10-11 Nihonbashi, Kobuna-cho, Chuo-ku, Tokyo 103-8351, Japan.
authors: Hidetomo
authors: H
authors: Sakurai
authors: Department of Pharmacology, Faculty of Pharmaceutical Sciences, Tohoku Medical and Pharmaceutical University, 4-4-1 Komatsushima, Aoba-ku, Sendai 981-8558, Japan. Electronic address: koichi@tohoku-mpu.ac.jp.
authors: Koichi
authors: K
authors: Tan-No
mesh_terms: D000818:Animals; D002809:Chondroitin Sulfates / Q000494:pharmacology*; D005557:Formaldehyde; D006930:Hyperalgesia / Q000139:chemically induced* / Q000517:prevention & control*; D008297:Male; D051379:Mice; D009474:Neurons / Q000187:drug effects / Q000378:metabolism; D010766:Phosphorylation / Q000187:drug effects; D016760:Proto-Oncogene Proteins c-fos / Q000096:biosynthesis / Q000235:genetics / Q000378:metabolism; D013116:Spinal Cord / Q000187:drug effects / Q000378:metabolism; D048051:p38 Mitogen-Activated Protein Kinases / Q000378:metabolism
chemical_list: D016760:Proto-Oncogene Proteins c-fos; D005557:Formaldehyde; D002809:Chondroitin Sulfates; D048051:p38 Mitogen-Activated Protein Kinases
keywords: Chondroitin sulfate; Spinal cord; Tactile allodynia