title: Impact of Malondialdehyde-Modified Low-Density Lipoprotein on Tissue Characteristics in Patients With Stable Coronary Artery Disease　- Integrated Backscatter-Intravascular Ultrasound Study.
abstract: BACKGROUND
  Malondialdehyde-modified low-density lipoprotein (MDA-LDL) is considered to play an essential role in plaque destabilization. We aimed to investigate the association between the tissue characteristics of culprit plaque assessed by integrated backscatter (IB)-intravascular ultrasound (IVUS) and the serum MDA-LDL levels in patients with stable coronary artery disease.
  
  
  RESULTS
  The study group consisted of 179 patients undergoing IB-IVUS during elective percutaneous coronary intervention. Patients were classified into 2 groups based on serum MDA-LDL level: low MDA-LDL group (<102 U/L, n=88) and high MDA-LDL group (≥102 U/L, n=91). Plaques in the high MDA-LDL group had higher %lipid (45.2±12.5% vs. 54.9±14.5%, P<0.001) and lower %fibrosis (43.0±9.1% vs. 36.4±11.4%, P<0.001) than did plaques in the low MDA-LDL group. Lipid-rich plaque (%lipid >60% or %fibrosis <30%) was significantly more frequently found in the high MDA-LDL group than in the low MDA-LDL group (14.3% vs. 39.8%, P<0.001). The incidence of MACE (cardiac death, myocardial infarction and/or hospitalization for heart failure) during 3 years was significantly higher in the high MDA-LDL group than in the low MDA-LDL group (6.6% vs. 15.9%, P=0.02).
  
  
  CONCLUSIONS
  Higher MDA-LDL might be associated with greater lipid and lower fibrous content, contributing to coronary plaque vulnerability. (Circ J 2016; 80: 2173-2182).
authors: Department of Cardiovascular Medicine, Hiroshima University Graduate School of Biomedical and Health Sciences.
authors: Hiroki
authors: H
authors: Ikenaga
authors: Satoshi
authors: S
authors: Kurisu
authors: Shingo
authors: S
authors: Kono
authors: Yoji
authors: Y
authors: Sumimoto
authors: Noriaki
authors: N
authors: Watanabe
authors: Takashi
authors: T
authors: Shimonaga
authors: Tadanao
authors: T
authors: Higaki
authors: Toshitaka
authors: T
authors: Iwasaki
authors: Naoya
authors: N
authors: Mitsuba
authors: Ken
authors: K
authors: Ishibashi
authors: Yoshihiro
authors: Y
authors: Dohi
authors: Yukihiro
authors: Y
authors: Fukuda
authors: Yasuki
authors: Y
authors: Kihara
mesh_terms: D000368:Aged; D003324:Coronary Artery Disease / Q000000981:diagnostic imaging* / Q000378:metabolism*; D005260:Female; D006801:Humans; D008077:Lipoproteins, LDL / Q000378:metabolism*; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism*; D008875:Middle Aged; D012189:Retrospective Studies; D018084:Ultrasonography, Interventional
chemical_list: D008077:Lipoproteins, LDL; D008315:Malondialdehyde