title: Small Molecule Survivin Inhibitor YM155 Displays Potent Activity Against Human Osteosarcoma Cells.
abstract: Survivin is an important oncogenic protein expressed highly in osteosarcoma. Here, we have shown that small molecule inhibitor YM155 potently suppressed survivin expression, inhibited cell growth, and induced apoptosis in osteosarcoma cells. Furthermore, we also showed that knock down of survivin by small interfering RNA strongly inhibited cell viability in two osteosarcoma cell lines, suggesting that suppression of survivin essentially contributes to YM155-mediated anticancer activity in osteosarcoma cells. Collectively, our study suggests that YM155 holds promise for patients with osteosarcoma.
authors: a Department of Pediatric Surgery , People's Hospital of Zhengzhou University , Zhengzhou , China.
authors: Shufeng
authors: S
authors: Zhang
authors: a Department of Pediatric Surgery , People's Hospital of Zhengzhou University , Zhengzhou , China.
authors: Xiaohui
authors: X
authors: Wang
authors: b Department of Ophthalmology , The Fifth Affiliated Hospital of Zhengzhou University , Zhengzhou , China.
authors: Zhimin
authors: Z
authors: Gu
authors: a Department of Pediatric Surgery , People's Hospital of Zhengzhou University , Zhengzhou , China.
authors: Li
authors: L
authors: Wang
mesh_terms: D000970:Antineoplastic Agents / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects / Q000235:genetics; D015972:Gene Expression Regulation, Neoplastic / Q000187:drug effects; D055785:Gene Knockdown Techniques; D006801:Humans; D007093:Imidazoles / Q000494:pharmacology*; D051034:Inhibitor of Apoptosis Proteins / Q000037:antagonists & inhibitors* / Q000235:genetics; D009285:Naphthoquinones / Q000494:pharmacology*; D012516:Osteosarcoma; D000077022:Survivin; D014410:Tumor Stem Cell Assay
chemical_list: D000970:Antineoplastic Agents; C107489:BIRC5 protein, human; D007093:Imidazoles; D051034:Inhibitor of Apoptosis Proteins; D009285:Naphthoquinones; D000077022:Survivin; C523798:sepantronium
keywords: YM155; apoptosis; osteosarcoma; survivin