title: CD151 Gene and Protein Expression Provides Independent Prognostic Information for Patients with Adenocarcinoma of the Esophagus and Gastroesophageal Junction Treated by Esophagectomy.
abstract: Esophageal and gastroesophageal junctional (GEJ) adenocarcinoma is one of the most fatal cancers and has the fastest rising incidence rate of all cancers. Identification of biomarkers is needed to tailor treatments to each patient's tumor biology and prognosis.
  
  
  
  Gene expression profiling was performed in a test cohort of 80 chemoradiotherapy (CRTx)-naïve patients with external validation in a separate cohort of 62 CRTx-naïve patients and 169 patients with advanced-stage disease treated with CRTx.
  
  
  
  As a novel prognostic biomarker after external validation, CD151 showed promise. Patients exhibiting high levels of CD151 (≥median) had a longer median overall survival than patients with low CD151 tumor levels (median not reached vs. 30.9 months; p = 0.01). This effect persisted in a multivariable Cox-regression model with adjustment for tumor stage [adjusted hazard ratio (aHR), 0.33; 95 % confidence interval (CI), 0.14-0.78; p = 0.01] and was further corroborated through immunohistochemical analysis (aHR, 0.22; 95 % CI, 0.08-0.59; p = 0.003). This effect was not found in the separate cohort of CRTx-exposed patients.
  
  
  
  Tumoral expression levels of CD151 may provide independent prognostic information not gained by conventional staging of patients with esophageal and GEJ adenocarcinoma treated by esophagectomy alone.
authors: Gastroesophageal Cancer Program, St. Vincent's Centre for Applied Medical Research, Sydney, Australia.|School of Medical Sciences, UNSW Australia, Sydney, Australia.|Department of Surgery, School of Medicine, University of Notre Dame, Sydney, Australia.
authors: Oliver M
authors: OM
authors: Fisher
authors: Gastroesophageal Cancer Program, St. Vincent's Centre for Applied Medical Research, Sydney, Australia.
authors: Angelique J
authors: AJ
authors: Levert-Mignon
authors: Gastroesophageal Cancer Program, St. Vincent's Centre for Applied Medical Research, Sydney, Australia.
authors: Christopher W
authors: CW
authors: Lehane
authors: Gastroesophageal Cancer Program, St. Vincent's Centre for Applied Medical Research, Sydney, Australia.
authors: Natalia K
authors: NK
authors: Botelho
authors: School of Medical Sciences, UNSW Australia, Sydney, Australia.|Genomics & Epigenetics Division, Garvan Institute of Medical Research, Sydney, Australia.
authors: Jesper L V
authors: JL
authors: Maag
authors: Gastroesophageal Cancer Program, St. Vincent's Centre for Applied Medical Research, Sydney, Australia.
authors: Melissa L
authors: ML
authors: Thomas
authors: Douglass Hanley Moir Pathology, Sydney, Australia.
authors: Melanie
authors: M
authors: Edwards
authors: Gastroesophageal Cancer Program, St. Vincent's Centre for Applied Medical Research, Sydney, Australia.|NHMRC Clinical Trials Centre, University of Sydney, Sydney, Australia.|Department of Surgery, School of Medicine, University of Notre Dame, Sydney, Australia.
authors: Sarah J
authors: SJ
authors: Lord
authors: Gastroesophageal Cancer Program, St. Vincent's Centre for Applied Medical Research, Sydney, Australia.
authors: Yuri V
authors: YV
authors: Bobryshev
authors: QIMR Berghofer Medical Research Institute, Brisbane, Australia.
authors: David C
authors: DC
authors: Whiteman
authors: Gastroesophageal Cancer Program, St. Vincent's Centre for Applied Medical Research, Sydney, Australia. rvlord@stvincents.com.au.|Department of Surgery, School of Medicine, University of Notre Dame, Sydney, Australia. rvlord@stvincents.com.au.
authors: Reginald V
authors: RV
authors: Lord
mesh_terms: D000230:Adenocarcinoma / Q000235:genetics* / Q000378:metabolism / Q000473:pathology / Q000628:therapy; D000368:Aged; D014408:Biomarkers, Tumor / Q000235:genetics / Q000378:metabolism; D059186:Chemoradiotherapy, Adjuvant; D004938:Esophageal Neoplasms / Q000235:genetics* / Q000378:metabolism / Q000473:pathology / Q000628:therapy; D016629:Esophagectomy; D004943:Esophagogastric Junction; D005260:Female; D015870:Gene Expression; D020869:Gene Expression Profiling; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011379:Prognosis; D016016:Proportional Hazards Models; D015996:Survival Rate; D060185:Tetraspanin 24 / Q000235:genetics* / Q000378:metabolism
chemical_list: D014408:Biomarkers, Tumor; C554715:CD151 protein, human; D060185:Tetraspanin 24