title: Meningiomas and Proteomics: Focus on New Potential Biomarkers and Molecular Pathways.
abstract: Meningiomas are one of the most common tumors affecting the central nervous system, exhibiting a great heterogeneity in grading, treatment and molecular background. This article provides an overview of the current literature regarding the molecular aspect of meningiomas. Analysis of potential biomarkers in serum, cerebrospinal fluid (CSF) and pathological tissues was reported. Applying bioinformatic methods and matching the common proteic profile, arising from different biological samples, we highlighted the role of nine proteins, particularly related to tumorigenesis and grading of meningiomas: serpin peptidase inhibitor alpha 1, ceruloplasmin, hemopexin, albumin, C3, apolipoprotein, haptoglobin, amyloid-P-component serum and alpha-1-beta-glycoprotein. These proteins and their associated pathways, including complement and coagulation cascades, plasma lipoprotein particle remodeling and lipid metabolism could be considered possible diagnostic, prognostic biomarkers, and eventually therapeutic targets. Further investigations are needed to better characterize the role of these proteins and pathways in meningiomas. The role of new therapeutic strategies are also discussed.
authors: Biomedical Sciences and Morphological and Functional Imaging, Gaetano Martino, Polyclinic University Hospital University of Messina, Messina, Italy rv.abbritti@hotmail.it.
authors: Rosaria Viola
authors: RV
authors: Abbritti
authors: Biomedical Sciences and Morphological and Functional Imaging, Gaetano Martino, Polyclinic University Hospital University of Messina, Messina, Italy.
authors: Francesca
authors: F
authors: Polito
authors: Clinical and Experimental Medicine, Gaetano Martino, Polyclinic University Hospital University of Messina, Messina, Italy.
authors: Maria
authors: M
authors: Cucinotta
authors: Clinical and Experimental Medicine, Gaetano Martino, Polyclinic University Hospital University of Messina, Messina, Italy.
authors: Claudio
authors: C
authors: Lo Giudice
authors: Biomedical Sciences and Morphological and Functional Imaging, Gaetano Martino, Polyclinic University Hospital University of Messina, Messina, Italy.
authors: Maria
authors: M
authors: Caffo
authors: Biomedical Sciences and Morphological and Functional Imaging, Gaetano Martino, Polyclinic University Hospital University of Messina, Messina, Italy.
authors: Chiara
authors: C
authors: Tomasello
authors: Biomedical Sciences and Morphological and Functional Imaging, Gaetano Martino, Polyclinic University Hospital University of Messina, Messina, Italy.
authors: Antonino
authors: A
authors: Germanò
authors: Clinical and Experimental Medicine, Gaetano Martino, Polyclinic University Hospital University of Messina, Messina, Italy.
authors: Mohammed
authors: M
authors: Aguennouz
mesh_terms: D015415:Biomarkers; D019295:Computational Biology / Q000379:methods; D063990:Gene Ontology; D006801:Humans; D008579:Meningioma / Q000235:genetics / Q000378:metabolism*; D025941:Protein Interaction Mapping; D060066:Protein Interaction Maps; D020543:Proteome; D040901:Proteomics / Q000379:methods; D015398:Signal Transduction
chemical_list: D015415:Biomarkers; D020543:Proteome
keywords: Meningioma; bioinformatic analysis; protein pathways; proteomic