title: Epidermal Growth Factor Receptor Signaling Regulates β Cell Proliferation in Adult Mice.
abstract: A thorough understanding of the signaling pathways involved in the regulation of β cell proliferation is an important initial step in restoring β cell mass in the diabetic patient. Here, we show that epidermal growth factor receptor 1 (EGFR) was significantly up-regulated in the islets of C57BL/6 mice after 50% partial pancreatectomy (PPx), a model for workload-induced β cell proliferation. Specific deletion of EGFR in the β cells of adult mice impaired β cell proliferation at baseline and after 50% PPx, suggesting that the EGFR signaling pathway plays an essential role in adult β cell proliferation. Further analyses showed that β cell-specific depletion of EGFR resulted in impaired expression of cyclin D1 and impaired suppression of p27 after PPx, both of which enhance β cell proliferation. These data highlight the importance of EGFR signaling and its downstream signaling cascade in postnatal β cell growth.
authors: From the Division of Pediatric Surgery, Department of Surgery, Children's Hospital of Pittsburgh, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15224.|Department of Oncology, the Third Xiangya Hospital of Central South University, 138 Tongzipo Road, Changsha 410013, China, and.
authors: Zewen
authors: Z
authors: Song
authors: From the Division of Pediatric Surgery, Department of Surgery, Children's Hospital of Pittsburgh, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15224.
authors: Joseph
authors: J
authors: Fusco
authors: From the Division of Pediatric Surgery, Department of Surgery, Children's Hospital of Pittsburgh, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15224.
authors: Ray
authors: R
authors: Zimmerman
authors: From the Division of Pediatric Surgery, Department of Surgery, Children's Hospital of Pittsburgh, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15224.
authors: Shane
authors: S
authors: Fischbach
authors: From the Division of Pediatric Surgery, Department of Surgery, Children's Hospital of Pittsburgh, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15224.|Department of Pediatric Surgery, the Second Affiliated Hospital & Yuying Children's Hospital, Wenzhou Medical University, Wenzhou 325000, China.
authors: Congde
authors: C
authors: Chen
authors: From the Division of Pediatric Surgery, Department of Surgery, Children's Hospital of Pittsburgh, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15224.
authors: David Matthew
authors: DM
authors: Ricks
authors: From the Division of Pediatric Surgery, Department of Surgery, Children's Hospital of Pittsburgh, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15224.
authors: Krishna
authors: K
authors: Prasadan
authors: From the Division of Pediatric Surgery, Department of Surgery, Children's Hospital of Pittsburgh, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15224.
authors: Chiyo
authors: C
authors: Shiota
authors: From the Division of Pediatric Surgery, Department of Surgery, Children's Hospital of Pittsburgh, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15224, Xiangwei.xiao@chp.edu.
authors: Xiangwei
authors: X
authors: Xiao
authors: From the Division of Pediatric Surgery, Department of Surgery, Children's Hospital of Pittsburgh, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15224, gittesgk@upmc.edu.
authors: George K
authors: GK
authors: Gittes
mesh_terms: D000818:Animals; D049109:Cell Proliferation / Q000502:physiology*; D019938:Cyclin D1 / Q000235:genetics / Q000378:metabolism; D066246:ErbB Receptors / Q000235:genetics / Q000378:metabolism*; D050417:Insulin-Secreting Cells / Q000378:metabolism*; D051379:Mice; D008822:Mice, Transgenic; D015398:Signal Transduction / Q000502:physiology*
chemical_list: C530105:Ccnd1 protein, mouse; D019938:Cyclin D1; C541485:EGFR protein, mouse; D066246:ErbB Receptors
keywords: beta cell (β cell); cell proliferation; cyclin D1; diabetes; epidermal growth factor receptor (EGFR)