title: Prognostic Significance of Estimated Glomerular Filtration Rate and Cystatin C in Patients with Acute Intracerebral Hemorrhage.
abstract: The effects of the estimated glomerular filtration rate (eGFR) and cystatin C on clinical outcomes on intracerebral hemorrhage (ICH) remain unclear. We investigated the associations of eGFR and cystatin C with 3-month functional outcome and all-cause mortality in acute ICH patients.
  
  
  
  A total of 365 patients with acute ICH were enrolled. Serum creatinine and cystatin C levels were measured within 24 h of admission. Outcomes at 3-month were evaluated by interviews with patients or their family members. Poor functional outcome was defined as a modified Rankin Scale score ≥3.
  
  
  
  During the 3-month follow-up, 154 patients experienced poor functional outcome, and 48 patients died from all causes. Low eGFR level was associated with poor outcome (adjusted OR 8.95; 95% CI 2.13-37.66; p-trend = 0.045) and all-cause mortality (adjusted hazards ratio (HR) 5.10; 95% CI 2.00-13.03; p-trend = 0.001). Additionally, a high cystatin C level was also found to be associated with all-cause mortality (adjusted HR 4.01; 95% CI 1.09-14.72; p-trend = 0.015). However, no significant association between cystatin C and poor functional outcome was observed (p-trend = 0.615).
  
  
  
  Low eGFR at baseline predicts poor functional outcome and all-cause mortality at 3-month in acute ICH patients. Also, high cystatin C was associated with increased risk of mortality but not with poor functional outcome.
authors: Department of Neurology and Suzhou Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow University, Suzhou, China.
authors: Shoujiang
authors: S
authors: You
authors: Luyao
authors: L
authors: Shi
authors: Chongke
authors: C
authors: Zhong
authors: Jiaping
authors: J
authors: Xu
authors: Qiao
authors: Q
authors: Han
authors: Xia
authors: X
authors: Zhang
authors: Huihui
authors: H
authors: Liu
authors: Yanlin
authors: Y
authors: Zhang
authors: Jijun
authors: J
authors: Shi
authors: Zhichao
authors: Z
authors: Huang
authors: Yongjun
authors: Y
authors: Cao
authors: Chunfeng
authors: C
authors: Liu
mesh_terms: D000208:Acute Disease; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood; D002543:Cerebral Hemorrhage / Q000097:blood / Q000175:diagnosis* / Q000401:mortality / Q000503:physiopathology; D016009:Chi-Square Distribution; D055316:Cystatin C / Q000097:blood*; D004185:Disability Evaluation; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D053208:Kaplan-Meier Estimate; D007668:Kidney / Q000503:physiopathology*; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D016017:Odds Ratio; D011237:Predictive Value of Tests; D011379:Prognosis; D016016:Proportional Hazards Models; D020127:Recovery of Function; D051436:Renal Insufficiency, Chronic / Q000097:blood / Q000175:diagnosis* / Q000401:mortality / Q000503:physiopathology; D012307:Risk Factors; D013997:Time Factors; D055815:Young Adult
chemical_list: D015415:Biomarkers; C525030:CST3 protein, human; D055316:Cystatin C