title: How cancer cells dictate their microenvironment: present roles of extracellular vesicles.
abstract: Intercellular communication plays an important role in cancer initiation and progression through secretory molecules, including growth factors and cytokines. Recent advances have revealed that small membrane vesicles, termed extracellular vesicles (EVs), served as a regulatory agent in the intercellular communication of cancer. EVs enable the transfer of functional molecules, including proteins, mRNA and microRNAs (miRNAs), into recipient cells. Cancer cells utilize EVs to dictate the unique phenotype of surrounding cells, thereby promoting cancer progression. Against such "education" by cancer cells, non-tumoral cells suppress cancer initiation and progression via EVs. Therefore, researchers consider EVs to be important cues to clarify the molecular mechanisms of cancer biology. Understanding the functions of EVs in cancer progression is an important aspect of cancer biology that has not been previously elucidated. In this review, we summarize experimental data that indicate the pivotal roles of EVs in cancer progression.
authors: Division of Molecular and Cellular Medicine, National Cancer Center Research Institute, 5-1-1, Tsukiji, Chuo-ku, Tokyo, 104-0045, Japan.
authors: Yutaka
authors: Y
authors: Naito
authors: Division of Molecular and Cellular Medicine, National Cancer Center Research Institute, 5-1-1, Tsukiji, Chuo-ku, Tokyo, 104-0045, Japan.
authors: Yusuke
authors: Y
authors: Yoshioka
authors: Division of Molecular and Cellular Medicine, National Cancer Center Research Institute, 5-1-1, Tsukiji, Chuo-ku, Tokyo, 104-0045, Japan.
authors: Yusuke
authors: Y
authors: Yamamoto
authors: Division of Molecular and Cellular Medicine, National Cancer Center Research Institute, 5-1-1, Tsukiji, Chuo-ku, Tokyo, 104-0045, Japan. tochiya@ncc.go.jp.
authors: Takahiro
authors: T
authors: Ochiya
mesh_terms: D000818:Animals; D002450:Cell Communication; D018450:Disease Progression; D055354:Exosomes / Q000276:immunology / Q000378:metabolism / Q000473:pathology*; D000067128:Extracellular Vesicles / Q000276:immunology / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D007107:Immune System / Q000276:immunology / Q000378:metabolism / Q000473:pathology; D007111:Immunity, Cellular; D009369:Neoplasms / Q000276:immunology / Q000378:metabolism / Q000473:pathology*; D059016:Tumor Microenvironment
keywords: Apoptotic body; Endothelial cells; Epithelial cells; Exosome; Fibroblasts; Immune cells; Mesenchymal stem cells; Microvesicle