title: Effectiveness of Rabbit Antithymocyte Globulin in Chronic Lung Allograft Dysfunction.
abstract: BACKGROUND
  Rabbit antithymocyte globulin (rATG) therapy has been shown to be beneficial in lung transplant recipients as induction therapy for treating acute lung rejection; however, its role in chronic lung rejection has been reported only rarely. We evaluated the effectiveness of rATG therapy in slowing the progression of chronic lung allograft dysfunction (CLAD) syndrome.
  
  
  METHODS
  We conducted a retrospective review of 25 lung transplant patients with CLAD who received rATG therapy in the Pulmonary Institute of Rabin Medical Center, Israel, between May 2005 and February 2016. Response to treatment was divided into 2 categories: stabilization, defined as a halting of the decline of forced expiratory volume in 1 second (FEV1) for ≥6 months after rATG therapy, and deterioration, defined as showing a continued decline in FEV1.
  
  
  RESULTS
  Of 25 subjects, 8 (32%) were categorized as part of the stabilization group and 17 (68%) were categorized as showing continued deterioration. The stabilization group was older (61 ± 8 vs 44 ± 19 years) and showed longer survival rate after rATG therapy (930 ± 385 vs 414 ± 277 days). The stabilization group also demonstrated a lower mean white blood cell count (7.9 ± 1.8 vs 8.5 ± 2.9 × 10(9) cells/L) and lymphocyte count (0.37 ± 0.1 vs 0.55 ± 0.3 × 10(9) cells/L) during rATG treatment. The stabilization group also demonstrated a higher FEV1 after lung transplantation (91% ± 21% vs 75% ± 15.4%), at the beginning of rATG therapy (51% ± 11% vs 39% ± 9.6%) and at 6 months after rATG therapy follow-up (51% ± 9.1% vs 28% ± 7.6%).
  
  
  CONCLUSIONS
  rATG was effective in stabilizing rejection progression in approximately one-third of our patients with CLAD. rATG therapy should be considered early in the course of CLAD. Randomized, controlled studies should be considered to confirm these findings.
authors: Rabin Medical Center, Pulmonary Institute, Petah Tiqva, Israel; The Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel. Electronic address: shimixyz@gmail.com.
authors: S
authors: S
authors: Izhakian
authors: Mayanei HaYeshua Medical Center, Bnei Brak, Israel; Rambam Health Care Campus, Haifa, Israel.
authors: W G
authors: WG
authors: Wasser
authors: Rabin Medical Center, Pulmonary Institute, Petah Tiqva, Israel; The Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.
authors: B D
authors: BD
authors: Fox
authors: Rabin Medical Center, Pulmonary Institute, Petah Tiqva, Israel; The Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.
authors: B
authors: B
authors: Vainshelboim
authors: Discipline of Physiotherapy, College of Healthcare Sciences, James Cook University, Queensland, Australia.
authors: J E
authors: JE
authors: Reznik
authors: Rabin Medical Center, Pulmonary Institute, Petah Tiqva, Israel; The Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.
authors: M R
authors: MR
authors: Kramer
mesh_terms: D000328:Adult; D064591:Allografts; D000818:Animals; D000961:Antilymphocyte Serum / Q000627:therapeutic use*; D005260:Female; D006084:Graft Rejection / Q000188:drug therapy*; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D007557:Israel; D016040:Lung Transplantation; D008297:Male; D008875:Middle Aged; D011817:Rabbits; D012189:Retrospective Studies; D015996:Survival Rate
chemical_list: D000961:Antilymphocyte Serum; D007166:Immunosuppressive Agents