title: The life cycle of phagosomes: formation, maturation, and resolution.
abstract: Phagocytosis, the regulated uptake of large particles (>0.5 μm in diameter), is essential for tissue homeostasis and is also an early, critical component of the innate immune response. Phagocytosis can be conceptually divided into three stages: phagosome, formation, maturation, and resolution. Each of these involves multiple reactions that require exquisite spatial and temporal orchestration. The molecular events underlying these stages are being unraveled and the current state of knowledge is briefly summarized in this article.
authors: Program in Cell Biology, Hospital for Sick Children, Toronto, ON, Canada.|Department of Biochemistry, University of Toronto, Toronto, ON, Canada.
authors: Roni
authors: R
authors: Levin
authors: Program in Cell Biology, Hospital for Sick Children, Toronto, ON, Canada.|Department of Biochemistry, University of Toronto, Toronto, ON, Canada.|Keenan Research Centre of the Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, ON, Canada.
authors: Sergio
authors: S
authors: Grinstein
authors: Program in Cell Biology, Hospital for Sick Children, Toronto, ON, Canada.
authors: Johnathan
authors: J
authors: Canton
mesh_terms: D000818:Animals; D006706:Homeostasis; D006801:Humans; D007113:Immunity, Innate; D010587:Phagocytosis; D010588:Phagosomes / Q000502:physiology*
keywords: bacterial; dendritic cells; fungal; lipid mediators; monocytes/macrophages; neutrophils