title: The influence of chemotherapy-associated sinusoidal dilatation on short-term outcome after partial hepatectomy for colorectal liver metastases: A systematic review with meta-analysis.
abstract: BACKGROUND
  Hepatic sinusoidal dilatation (SD) is a histopathological entity that occurs in up to 75% of patients undergoing oxaliplatin-based chemotherapy for colorectal liver metastases (CRLM).
  
  
  OBJECTIVE
  To study the influence of SD on outcome after partial hepatectomy in patients with CRLM.
  
  
  METHODS
  Medline, Embase, CENTRAL, LILACS and CINAHL were searched for studies published between 01.01.2004 and 09.06.2015 with keywords: "sinusoidal obstruction syndrome", "hepatic veno-occlusive disease", and "Stuart-Bras syndrome". Studies comprising adults who underwent partial hepatectomy for CRLM with grading of SD and registration of postoperative morbidity and/or mortality were included. Risk of bias and quality of studies were evaluated with the Quality In Prognosis Studies Instrument (QUIPS) and modified GRADE framework.
  
  
  RESULTS
  Search strategies produced 2007 hits from which 23 and 13 articles were extracted for qualitative and quantitative analyses, respectively. Meta-analysis on the influence of SD grade 2-3 vs. SD grade 0-1 on postoperative overall morbidity showed an odds ratio (OR) of 1.26 [95% CI 0.74, 2.15](p = 0.40), an OR of 1.03 [0.15, 6.89](p = 0.98) for liver failure, an OR of 1.21 [0.23, 6.35](p = 0.82) for overall mortality, and an OR of 3.52 [0.31, 39.91](p = 0.31) for liver-related morbidity. QUIPS showed a low to high risk of bias for studies, and GRADE showed very low quality of evidence per outcome.
  
  
  CONCLUSIONS
  No significant effect of SD grade 2-3 on short-term outcome after partial hepatectomy was found. However, the data on which this conclusion was based were not very robust and therefore no solid conclusions could be drawn.
authors: Department of Surgery, Maastricht University Medical Centre & NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University, Universiteitssingel 40, 6229 ER, Maastricht, The Netherlands. Electronic address: k.vanmierlo@maastrichtuniversity.nl.
authors: Kim M C
authors: KM
authors: van Mierlo
authors: Department of Surgery, Maastricht University Medical Centre & NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University, Universiteitssingel 40, 6229 ER, Maastricht, The Netherlands. Electronic address: junfang.zhao@maastrichtuniversity.nl.
authors: Junfang
authors: J
authors: Zhao
authors: Kleijnen Systematic Reviews Ltd, York, United Kingdom; CAPHRI School for Public Health and Primary Care, Maastricht University, Universiteitssingel 40, 6229 ER, Maastricht, The Netherlands. Electronic address: jos@systematic-reviews.com.
authors: Jos
authors: J
authors: Kleijnen
authors: Department of Surgery, Maastricht University Medical Centre & NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University, Universiteitssingel 40, 6229 ER, Maastricht, The Netherlands. Electronic address: s.rensen@maastrichtuniversity.nl.
authors: Sander S
authors: SS
authors: Rensen
authors: Department of Surgery, Maastricht University Medical Centre & NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University, Universiteitssingel 40, 6229 ER, Maastricht, The Netherlands. Electronic address: frank.schaap@maastrichtuniversity.nl.
authors: Frank G
authors: FG
authors: Schaap
authors: Department of Surgery, Maastricht University Medical Centre & NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University, Universiteitssingel 40, 6229 ER, Maastricht, The Netherlands; GROW School for Oncology and Developmental Biology, Maastricht University, Universiteitssingel 40, 6229 ER, Maastricht, The Netherlands. Electronic address: chc.dejong@mumc.nl.
authors: Cornelis H C
authors: CH
authors: Dejong
authors: Department of Surgery, Maastricht University Medical Centre & NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University, Universiteitssingel 40, 6229 ER, Maastricht, The Netherlands; Department of HPB Surgery & Liver Transplantation, Institute for Liver and Digestive Health, Royal Free Hospital, University College London, London, United Kingdom. Electronic address: steven.oldedamink@maastrichtuniversity.nl.
authors: Steven W M
authors: SW
authors: Olde Damink
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects*; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology* / Q000473:pathology; D015179:Colorectal Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D004108:Dilatation, Pathologic / Q000209:etiology* / Q000473:pathology; D006498:Hepatectomy; D006801:Humans; D008113:Liver Neoplasms / Q000188:drug therapy* / Q000556:secondary / Q000601:surgery; D011379:Prognosis
keywords: Chemotherapy-associated liver injury; Partial hepatectomy; Postoperative liver failure; SOS; Sinusoidal dilatation; Sinusoidal obstruction syndrome