title: Correlation Between Insight and Capacity to Consent to Research in Subjects With Bipolar Disorder Type I and Schizophrenia.
abstract: BACKGROUND
  Schizophrenia and bipolar disorder type I (BD-I) can affect patient autonomy and capacity to consent to participate in research. Other variables associated with the autonomy of patients must be explored in order to improve the quality of the currently available tools.
  
  
  OBJECTIVE
  To evaluate the relationship between insight and the capacity to consent to participate in research in patients with BD-I and schizophrenia.
  
  
  METHODS
  A cross-sectional and longitudinal study was conducted with 120 subjects (40 subjects with schizophrenia, 40 with BD-I, and 40 healthy controls). The tools used were the Scale Assessment Insight-Expanded (SAI-E) and the MacArthur Competence Assessment Tool-Treatment (MacCAT-CR), which was first adapted culturally, and its validity and reliability assessed. The results obtained on each scale were compared and the association between them were evaluated.
  
  
  RESULTS
  There is a direct correlation between the capacity to consent to research, measured using the MacCAT-CR tool, and the degree of insight, measured using the SAI-E scale, with an effect size of 1.3 for BD-I and 2.03 for schizophrenia.
  
  
  CONCLUSIONS
  The results suggest that there is a correlation between the degree of insight and the capacity to consent to research in subjects with schizophrenia and BD-I. Insight should therefore be included as a relevant variable to assess the capacity to consent, and future studies should include it when researching on or designing new tools which aim at a greater respect of patient autonomy.
authors: Mood Disorders Program, Hospital Universitario San Vicente Fundación, Medellín, Colombia; Research Group in Psychiatry (GIPSI), Department of Psychiatry, Universidad de Antioquia, Medellín, Colombia. Electronic address: carloslopezjaramillo@gmail.com.
authors: Carlos
authors: C
authors: López-Jaramillo
authors: Hospital Central de la Policía Nacional, Universidad Nacional de Colombia, and Universidad El Rosario, Bogotá, Colombia.
authors: Chantal Aristizábal
authors: CA
authors: Tobler
authors: Department of Bioethics, Universidad El Bosque, Bogotá, Colombia.
authors: Constanza Ovalle
authors: CO
authors: Gómez
authors: Department of Bioethics, Universidad El Bosque, Bogotá, Colombia.
authors: Jaime Escobar
authors: JE
authors: Triana
mesh_terms: D000328:Adult; D001714:Bipolar Disorder / Q000523:psychology*; D016022:Case-Control Studies; D032882:Comprehension; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D007258:Informed Consent / Q000523:psychology*; D008137:Longitudinal Studies; D008297:Male; D016743:Mental Competency / Q000523:psychology*; D008875:Middle Aged; D026684:Personal Autonomy; D011581:Psychological Tests; D015203:Reproducibility of Results; D012565:Schizophrenic Psychology
keywords: Autonomy; Autonomía; Bioethics; Bioética; Bipolar disorder; Esquizofrenia; Investigación; Research; Schizophrenia; Trastorno bipolar