title: Principal cell activity induces spine relocation of adult-born interneurons in the olfactory bulb.
abstract: Adult-born neurons adjust olfactory bulb (OB) network functioning in response to changing environmental conditions by the formation, retraction and/or stabilization of new synaptic contacts. While some changes in the odour environment are rapid, the synaptogenesis of adult-born neurons occurs over a longer time scale. It remains unknown how the bulbar network functions when rapid and persistent changes in environmental conditions occur but when new synapses have not been formed. Here we reveal a new form of structural remodelling where mature spines of adult-born but not early-born neurons relocate in an activity-dependent manner. Principal cell activity induces directional growth of spine head filopodia (SHF) followed by spine relocation. Principal cell-derived glutamate and BDNF regulate SHF motility and directional spine relocation, respectively; and spines with SHF are selectively preserved following sensory deprivation. Our three-dimensional model suggests that spine relocation allows fast reorganization of OB network with functional consequences for odour information processing.
authors: Cellular Neurobiology Unit,Institut Universitaire en santé mentale de Québec, Quebec City, Quebec, Canada G1J 2G3.
authors: Vincent
authors: V
authors: Breton-Provencher
authors: Cellular Neurobiology Unit,Institut Universitaire en santé mentale de Québec, Quebec City, Quebec, Canada G1J 2G3.
authors: Karen
authors: K
authors: Bakhshetyan
authors: Cellular Neurobiology Unit,Institut Universitaire en santé mentale de Québec, Quebec City, Quebec, Canada G1J 2G3.
authors: Delphine
authors: D
authors: Hardy
authors: Cellular Neurobiology Unit,Institut Universitaire en santé mentale de Québec, Quebec City, Quebec, Canada G1J 2G3.
authors: Rodrigo Roberto
authors: RR
authors: Bammann
authors: Department of Mathematics, University of Milan, Milan 20133, Italy.|Department of Neurobiology, Yale University School of Medicine, New Haven, Connecticut 06520, USA.
authors: Francesco
authors: F
authors: Cavarretta
authors: Cellular Neurobiology Unit,Institut Universitaire en santé mentale de Québec, Quebec City, Quebec, Canada G1J 2G3.
authors: Marina
authors: M
authors: Snapyan
authors: Cellular Neurobiology Unit,Institut Universitaire en santé mentale de Québec, Quebec City, Quebec, Canada G1J 2G3.|Centre d'optique, photonique et laser (COPL), Université Laval, Quebec City, Quebec, Canada G1V 0A6.
authors: Daniel
authors: D
authors: Côté
authors: Department of Mathematics, University of Milan, Milan 20133, Italy.|Department of Neurobiology, Yale University School of Medicine, New Haven, Connecticut 06520, USA.|Institute of Biophysics, National Research Council, Palermo 90146, Italy.
authors: Michele
authors: M
authors: Migliore
authors: Cellular Neurobiology Unit,Institut Universitaire en santé mentale de Québec, Quebec City, Quebec, Canada G1J 2G3.|Department of Psychiatry and Neuroscience, Université Laval, Quebec City, Quebec, Canada G1V 0A6.
authors: Armen
authors: A
authors: Saghatelyan
mesh_terms: D000818:Animals; D019208:Brain-Derived Neurotrophic Factor / Q000235:genetics / Q000378:metabolism; D002465:Cell Movement / Q000502:physiology; D049229:Dendritic Spines / Q000502:physiology*; D005260:Female; D018698:Glutamic Acid / Q000378:metabolism; D007091:Image Processing, Computer-Assisted; D007395:Interneurons / Q000166:cytology / Q000502:physiology*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008822:Mice, Transgenic; D023421:Models, Animal; D008954:Models, Biological; D055495:Neurogenesis / Q000502:physiology*; D009812:Odorants; D009830:Olfactory Bulb / Q000166:cytology / Q000502:physiology*; D011554:Pseudopodia / Q000502:physiology; D012683:Sensory Deprivation / Q000502:physiology; D012903:Smell / Q000502:physiology; D013569:Synapses / Q000502:physiology; D059008:Time-Lapse Imaging / Q000379:methods
chemical_list: D019208:Brain-Derived Neurotrophic Factor; D018698:Glutamic Acid