title: Role of a gitogenin-type steroidal saponin (3-O-β-d-glucopyranosyl (1→2)-β-d-glucopyranosyl (1→4)-β-d-galactopyranoside-25R,5α-spirostane-2α,3β-diol), isolated from the leaves of Malvastrum coromandelianum in regulating thyrotoxicosis in rats.
abstract: The hitherto unknown role of saponin in the regulation of thyrotoxicosis has been revealed in chemically-induced thyrotoxic rats. l-T4 (l-thyroxine) administration at pre-standardized dose of 500-μg/kg body weight for 12days increased the levels of thyroid hormones, enhanced the activity of hepatic 5'-monodeiodinase I (5'DI) and glucose-6-phosphatase (G-6Pase) as well as lipid peroxidation (LPO) with a parallel decrease in the levels of antioxidative enzymes. However, administration of the isolated saponin for 15days ameliorated the T4-induced alterations in serum thyroid hormones, hepatic LPO, G-6-Pase and 5'DI activity, and improved the cellular antioxidant status, indicating its antithyroidal and antioxidative potential. These effects of the test compound were comparable to a reference antithyroid drug, Propylthiouracil (PTU), suggesting that the test saponin may act as a potent anti-thyroid agent.
authors: School of Life Sciences, Devi Ahilya University, Indore 452017, India. Electronic address: spanda4@rediffmail.com.
authors: Sunanda
authors: S
authors: Panda
authors: School of Life Sciences, Devi Ahilya University, Indore 452017, India.
authors: Anand
authors: A
authors: Kar
mesh_terms: D000818:Animals; D013956:Antithyroid Agents / Q000737:chemistry / Q000302:isolation & purification / Q000627:therapeutic use*; D005260:Female; D019660:Malvaceae / Q000737:chemistry*; D018515:Plant Leaves / Q000737:chemistry*; D051381:Rats; D013150:Spirostans / Q000737:chemistry / Q000302:isolation & purification / Q000627:therapeutic use*; D013971:Thyrotoxicosis / Q000188:drug therapy*
chemical_list: D013956:Antithyroid Agents; D013150:Spirostans; C012999:gitogenin
keywords: Lipidperoxidation; Malvastrum coromandelianum; Rat; Saponin; Thyrotoxicosis