title: Metal-Free Remote C-H Bond Amidation of 8-Amidoquinolines on the C5 Position under Mild Conditions.
abstract: An efficient and facile process was developed for the remote C-H bond amidation of 8-aminoquinoline scaffolds on the C5 position which is geometric. The method only made use of PhI(OAc)2 as a mediator and showed good tolerance toward numerous dibenzenesulfonimides and amides, giving the corresponding products in moderate to excellent yield.
authors: State Key Laboratory of Natural Medicines, China Pharmaceutical University , Nanjing 210009, China.|Jiangsu Key Laboratory of Drug Design and Optimization, Department of Medicinal Chemistry, China Pharmaceutical University , Nanjing 210009, China.
authors: Dezhong
authors: D
authors: Ji
authors: State Key Laboratory of Natural Medicines, China Pharmaceutical University , Nanjing 210009, China.|Changzhou Vocational Institute of Engineering, Changzhou 213164, China.
authors: Xin
authors: X
authors: He
authors: Yizhu
authors: Y
authors: Xu
authors: Ziyue
authors: Z
authors: Xu
authors: Yuchen
authors: Y
authors: Bian
authors: Weixing
authors: W
authors: Liu
authors: State Key Laboratory of Natural Medicines, China Pharmaceutical University , Nanjing 210009, China.|Jiangsu Key Laboratory of Drug Design and Optimization, Department of Medicinal Chemistry, China Pharmaceutical University , Nanjing 210009, China.
authors: Qihua
authors: Q
authors: Zhu
authors: State Key Laboratory of Natural Medicines, China Pharmaceutical University , Nanjing 210009, China.|Jiangsu Key Laboratory of Drug Design and Optimization, Department of Medicinal Chemistry, China Pharmaceutical University , Nanjing 210009, China.
authors: Yungen
authors: Y
authors: Xu