title: Effect of PEGylated chitosan as multifunctional stabilizer for deacetyl mycoepoxydience nanosuspension design and stability evaluation.
abstract: Here a series of multifunctional stabilizers was designed and used in a nanosuspension stability enhancement study. Methoxypolyethylene glycol (M PEG)-grafted chitosan, accompanied by space steric hindrance, an electrostatic repulsion function, and a solvation effect, is a multifunctional stabilizer. Deacetyl mycoepoxydience (DM) nanosuspension was prepared using the anti-solvent precipitation approach. The effects of the DM and the multifunctional stabilizer concentration, solvent to anti-solvent ratio, crystallization and storage temperature, and ultrasonic time on drug particle formation during the anti-solvent processing were investigated and the nanosuspension stability was studied. The nanosuspension showed dendritic-like nanostructures and a crystalline state in a morphology and crystalline state study. The optimized drug and multifunctional stabilizer concentration range were selected through the response surface optimization method. The most appropriate and stable nanosuspension could be obtained through the optimal parameters. This study demonstrated that M PEG-grafted chitosan (M PEGC) could be used as a multifunctional stabilizer to control particle size and improve nanosuspension stability.
authors: School of Chemistry and Pharmaceutical Engineering, Qilu University of Technology, Jinan 250353, China.
authors: Juan
authors: J
authors: Du
authors: School of Chemistry and Pharmaceutical Engineering, Qilu University of Technology, Jinan 250353, China.
authors: Yuqi
authors: Y
authors: Zhou
authors: School of Chemistry and Pharmaceutical Engineering, Qilu University of Technology, Jinan 250353, China.
authors: Lulu
authors: L
authors: Wang
authors: School of Chemistry and Pharmaceutical Engineering, Qilu University of Technology, Jinan 250353, China. Electronic address: wangyancai1999@163.com.
authors: Yancai
authors: Y
authors: Wang
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000737:chemistry; D001952:Bridged-Ring Compounds / Q000008:administration & dosage* / Q000737:chemistry; D048271:Chitosan / Q000031:analogs & derivatives*; D003102:Colloids / Q000737:chemistry; D004337:Drug Carriers / Q000737:chemistry*; D004355:Drug Stability; D005079:Excipients / Q000737:chemistry; D053758:Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D010316:Particle Size; D011092:Polyethylene Glycols / Q000737:chemistry*; D011753:Pyrones / Q000008:administration & dosage* / Q000737:chemistry; D012995:Solubility
chemical_list: D000970:Antineoplastic Agents; D001952:Bridged-Ring Compounds; D003102:Colloids; D004337:Drug Carriers; D005079:Excipients; D011753:Pyrones; C476085:mycoepoxydiene; D011092:Polyethylene Glycols; C028210:monomethoxypolyethylene glycol; D048271:Chitosan
keywords: Chitosan; Chitosan (PubChem CID: 71853); Deacetyl mycoepoxydience; Methanol (PubChem CID: 887); N, N-dimethylformamide (PubChem CID: 6228); Nanosuspension; Phthalic anhydride (PubChem CID: 6811); Poloxamer 407 (PubChem CID: 24751); Polyethylene glycol (PubChem CID: 174); Polyvinylpyrrolidone (PubChem CID: 6917); Pyridine (PubChem CID: 1049); Sodium dodecyl sulfate (PubChem CID: 3423265); Stability; Thionyl chloride (PubChem CID: 24386)