title: Melokhanines A-J, Bioactive Monoterpenoid Indole Alkaloids with Diverse Skeletons from Melodinus khasianus.
abstract: The new melokhanines A-J (1-10) and 22 known (11-32) alkaloids were isolated from the twigs and leaves of Melodinus khasianus. The new compounds and their absolute configurations were elucidated by extensive analysis of spectroscopic, X-ray diffraction, and computational data. Melokhanine A (1), composed of a hydroxyindolinone linked to an octahydrofuro[2,3-b]pyridine moiety, is an unprecedented monoterpenoid indole alkaloid. Melokhanines B-H (2-8) possess a new 6/5/5/6/6 pentacyclic indole alkaloid skeleton. Alkaloids 1-16, 25-27, 31, and 32 showed the best antibacterial activity against Pseudomonas aeruginosa (MIC range 2-22 μM). Among the seven dermatophytes tested, compound 1 showed significant inhibitory activity against Microsporum canis, M. ferrugineum, and Trichophyton ajelloi (MIC range 38-150 μM), i.e., half the efficacy of the positive control, griseofulvin.
authors: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences , Kunming, 650201, People's Republic of China.|Yunnan Institute of Food Safety, Kunming University of Science and Technology , Kunming, 650500, People's Republic of China.|Yunnan Key Laboratory of Natural Medicinal Chemistry , Kunming, 650201, People's Republic of China.
authors: Gui-Guang
authors: GG
authors: Cheng
authors: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences , Kunming, 650201, People's Republic of China.|Yunnan Key Laboratory of Natural Medicinal Chemistry , Kunming, 650201, People's Republic of China.
authors: Dan
authors: D
authors: Li
authors: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences , Kunming, 650201, People's Republic of China.|Yunnan Key Laboratory of Natural Medicinal Chemistry , Kunming, 650201, People's Republic of China.
authors: Bo
authors: B
authors: Hou
authors: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences , Kunming, 650201, People's Republic of China.|Yunnan Key Laboratory of Natural Medicinal Chemistry , Kunming, 650201, People's Republic of China.
authors: Xiao-Nian
authors: XN
authors: Li
authors: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences , Kunming, 650201, People's Republic of China.|Yunnan Key Laboratory of Natural Medicinal Chemistry , Kunming, 650201, People's Republic of China.
authors: Lu
authors: L
authors: Liu
authors: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences , Kunming, 650201, People's Republic of China.|Yunnan Key Laboratory of Natural Medicinal Chemistry , Kunming, 650201, People's Republic of China.
authors: Ying-Ying
authors: YY
authors: Chen
authors: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences , Kunming, 650201, People's Republic of China.|Yunnan Key Laboratory of Natural Medicinal Chemistry , Kunming, 650201, People's Republic of China.
authors: Paul-Keilah
authors: PK
authors: Lunga
authors: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences , Kunming, 650201, People's Republic of China.|Yunnan Key Laboratory of Natural Medicinal Chemistry , Kunming, 650201, People's Republic of China.|Department of Chemistry, COMSATS Institute of Information Technology , Abbottabad-22060, Pakistan.
authors: Afsar
authors: A
authors: Khan
authors: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences , Kunming, 650201, People's Republic of China.|Yunnan Key Laboratory of Natural Medicinal Chemistry , Kunming, 650201, People's Republic of China.
authors: Ya-Ping
authors: YP
authors: Liu
authors: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences , Kunming, 650201, People's Republic of China.|Yunnan Key Laboratory of Natural Medicinal Chemistry , Kunming, 650201, People's Republic of China.
authors: Zhi-Li
authors: ZL
authors: Zuo
authors: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences , Kunming, 650201, People's Republic of China.|Yunnan Key Laboratory of Natural Medicinal Chemistry , Kunming, 650201, People's Republic of China.
authors: Xiao-Dong
authors: XD
authors: Luo
mesh_terms: D029062:Apocynaceae / Q000737:chemistry*; D018360:Crystallography, X-Ray; D004354:Drug Screening Assays, Antitumor; D004365:Drugs, Chinese Herbal / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D004926:Escherichia coli / Q000187:drug effects; D006118:Griseofulvin / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D008864:Microsporum / Q000187:drug effects; D008968:Molecular Conformation; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D018515:Plant Leaves / Q000737:chemistry; D018547:Plant Stems / Q000737:chemistry; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D046948:Secologanin Tryptamine Alkaloids / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D014249:Trichophyton / Q000187:drug effects
chemical_list: D004365:Drugs, Chinese Herbal; D046948:Secologanin Tryptamine Alkaloids; C000620734:melokhanine A; D006118:Griseofulvin