title: Hemostasis vs. epidural fibrosis?: A comparative study on an experimental rat model of laminectomy.
abstract: OBJECTIVE
  The aim of this study was to evaluate the histopathological and biochemical impact and effectiveness of two hemostatic agents, Ankaferd blood stopper (ABS) and Microporous Polysaccharide Hemospheres (MPH), on epidural fibrosis in an experimental rat laminectomy model.
  
  
  METHODS
  Twenty adult Wistar albino rats were divided into MPH-treated (n=6), ABS-treated (n=6) and control (n=8) groups. Laminectomy of the lumbar spine was performed in all animals and treatment groups were exposed to MPH and ABS while closure was applied in control group as per usual. Epidural fibrosis was evaluated in all groups macroscopically, histopathologically, biochemically and with electron microscopy four weeks later.
  
  
  RESULTS
  Statistically, it was found that MPH-treated group had significantly less epidural fibrosis compared to ABS-treated and control groups.
  
  
  CONCLUSIONS
  We compared two hemostatic agents for their propensity to cause adhesions in the present study. Our results show that MPH significantly reduces epidural scar formation and dural adhesion in a rat model of laminectomy while ABS increases postoperative fibrosis.
authors: Department of Neurosurgery, Anadolu Medical Center, Kocaeli, Turkey. Electronic address: drhakanerdogan@gmail.com.
authors: Hakan
authors: H
authors: Erdogan
authors: Faculty of Medicine, Department of Neurosurgery, Maltepe University, Istanbul, Turkey.
authors: Bilal
authors: B
authors: Kelten
authors: Cerrahpasa Faculty of Medicine, Department of Medical Biology, Istanbul University, Istanbul, Turkey.
authors: Matem
authors: M
authors: Tuncdemir
authors: Cerrahpasa Faculty of Medicine, Department of Histology and Embryology, Istanbul University, Istanbul, Turkey.
authors: Salime Pelin
authors: SP
authors: Erturkuner
authors: Cerrahpasa Faculty of Medicine, Department of Medical Biochemistry, Istanbul University, Istanbul, Turkey.
authors: Hafize
authors: H
authors: Uzun
authors: Faculty of Medicine, Department of Neurosurgery, Maltepe University, Istanbul, Turkey.
authors: Alper
authors: A
authors: Karaoglan
mesh_terms: D000818:Animals; D002921:Cicatrix / Q000378:metabolism / Q000473:pathology; D004824:Epidural Space / Q000378:metabolism / Q000473:pathology*; D005355:Fibrosis; D006489:Hemostatic Techniques; D006909:Hydroxyproline / Q000378:metabolism; D007796:Laminectomy / Q000379:methods*; D008863:Microspheres; D009195:Peroxidase / Q000378:metabolism; D010936:Plant Extracts / Q000627:therapeutic use*; D011134:Polysaccharides; D051381:Rats; D017208:Rats, Wistar; D000267:Tissue Adhesions / Q000378:metabolism / Q000473:pathology
chemical_list: D010936:Plant Extracts; D011134:Polysaccharides; C539751:ankaferd blood stopper; D009195:Peroxidase; D006909:Hydroxyproline
keywords: Epidural fibrosis; Hemostasis; Laminectomy; Rats