title: Factors Influencing the Prognosis of Octogenarians with Aortic Stenosis in the Advanced Aging Societies.
abstract: Objective The recognition of clinical symptoms is critical to developing an effective therapeutic strategy for aortic valve stenosis (AS). Although AS is common, little is known about the factors influencing the natural history of AS patients who are 80 years of age older in advanced aging societies. We investigated the natural history and indications for valve procedures in AS patients of 80 years of age or older. Methods The medical records of 108 consecutive AS patients (moderate grade or higher) who are 80 years of age or older (mean age, 84.2±3.9 years; female, 65 patients) were reviewed to investigate their symptoms, the development of congestive heart failure, the incidence of referral for aortic valve replacement and death. The median duration of follow-up was 9 months (interquartile range, 2 to 25 months). Results The probability of remaining free of events (valve replacement and death) was 29±13% in all patients. There was no significant difference in the aortic valve area of the symptomatic and asymptomatic patients (0.85±0.28 cm(2) vs. 0.88±0.25 cm(2), p=0.59). The aortic valve (AV) velocity and AV area index were predictors of subsequent cardiac events (p<0.05). Conclusion The severity of AS was the only factor to affect the prognosis of AS patients who were 80 years old of age or older. It is necessary to frequently monitor the subjective symptoms of such patients and to objectively measure the AV area.
authors: Division of Cardiology and Department of Laboratory Medicine, Shimane University Faculty of Medicine, Japan.
authors: Shuai
authors: S
authors: Liang
authors: Kazuto
authors: K
authors: Yamaguchi
authors: Hiroyuki
authors: H
authors: Yoshitomi
authors: Saki
authors: S
authors: Ito
authors: Ryuma
authors: R
authors: Nakashima
authors: Takashi
authors: T
authors: Sugamori
authors: Akihiro
authors: A
authors: Endo
authors: Nobuyuki
authors: N
authors: Takahashi
authors: Kazuaki
authors: K
authors: Tanabe
mesh_terms: D000367:Age Factors; D000369:Aged, 80 and over; D001024:Aortic Valve Stenosis / Q000150:complications / Q000401:mortality* / Q000601:surgery*; D005260:Female; D006333:Heart Failure / Q000150:complications; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D011379:Prognosis