title: Bronchiectasis and the risk of cardiovascular disease: a population-based study.
abstract: There are limited data on the burden of cardiovascular comorbidities in people with bronchiectasis. Our cross-sectional study estimates the burden of pre-existing diagnoses of coronary heart disease (CHD) and stroke in people with bronchiectasis compared with the general population. The historical cohort study investigates if individuals with bronchiectasis are at increased risk of incident CHD and stroke events.
  
  
  
  We used primary care electronic records from the Clinical Practice Research Datalink. The cross-sectional study used logistic regression to quantify the association between bronchiectasis and recorded diagnoses of CHD or stroke. Cox regression was used to investigate if people with bronchiectasis experienced increased incident CHD and strokes compared with the general population, adjusting for age, sex, smoking habit and other risk factors for cardiovascular disease.
  
  
  
  Pre-existing diagnoses of CHD (OR 1.33, 95% CI 1.25 to 1.41) and stroke (OR 1.92, 95% CI 1.85 to 2.01) were higher in people with bronchiectasis compared with those without bronchiectasis, after adjusting for age, sex, smoking and risk factors for cardiovascular disease. The rate of first CHD and stroke were also higher in people with bronchiectasis (HR for CHD 1.44 (95% CI 1.27 to 1.63) and HR for stroke 1.71 (95% CI 1.54 to 1.90)).
  
  
  
  The risk of CHD and stroke are higher among people with bronchiectasis compared with the general population. An increased awareness of these cardiovascular comorbidities in this population is needed to provide a more integrated approach to the care of these patients.
authors: Division of Epidemiology and Public Health, University of Nottingham, Nottingham, UK.|Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, UK.|Department of Respiratory Medicine, University of Nottingham, Nottingham, UK.
authors: Vidya
authors: V
authors: Navaratnam
authors: Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, UK.
authors: Elizabeth R C
authors: ER
authors: Millett
authors: Centre for Inflammation and Tissue Repair, University College London, London, UK.
authors: John R
authors: JR
authors: Hurst
authors: Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, UK.
authors: Sara L
authors: SL
authors: Thomas
authors: Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, UK.
authors: Liam
authors: L
authors: Smeeth
authors: Division of Epidemiology and Public Health, University of Nottingham, Nottingham, UK.
authors: Richard B
authors: RB
authors: Hubbard
authors: Centre for Inflammation and Tissue Repair, University College London, London, UK.
authors: Jeremy
authors: J
authors: Brown
authors: Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, UK.|Department of Respiratory Epidemiology, Occupational Medicine and Public Health, National Heart and Lung Institute, Imperial College London, London, UK.
authors: Jennifer K
authors: 0000-0003-0149-4869
authors: JK
authors: Quint
mesh_terms: D000328:Adult; D000368:Aged; D001987:Bronchiectasis / Q000150:complications* / Q000453:epidemiology; D002318:Cardiovascular Diseases / Q000150:complications* / Q000453:epidemiology; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D012307:Risk Factors; D020521:Stroke / Q000150:complications / Q000453:epidemiology; D006113:United Kingdom / Q000453:epidemiology
keywords: Bronchiectasis; Clinical Epidemiology