title: Correlation between mucin biology and tumor heterogeneity in lung cancer.
abstract: Mucins (MUC) are a family consisting of large O-glycoproteins whose primary functions are to protect and lubricate cell epithelial surfaces and contribute to intra- and inter-cellular signal pathways, cell proliferation, growth and apotosis. With the development of new technologies, MUCs begin to be identified as an effective marker in evaluating the tumor heterogeneity in lung cancer. MUCs' diverse expressions in subtypes of lung cancer indicate the inter-tumor heterogeneity. MUCs' mutation may also contribute to the development of intra-heterogeneity and evolution of lung cancer. Understanding MUCs' association with lung cancer heterogeneity and its molecular regulatory mechanism will benefit the development of diagnosis, therapy choice, and prognosis prediction of lung cancer.
authors: Zhongshan Hospital Institute of Clinical Science, Fudan University, Shanghai Institute of Clinical Bioinformatics, Biomedical Research Center, Shanghai, China.
authors: Menglin
authors: M
authors: Xu
authors: Zhongshan Hospital Institute of Clinical Science, Fudan University, Shanghai Institute of Clinical Bioinformatics, Biomedical Research Center, Shanghai, China.
authors: Diane C
authors: DC
authors: Wang
authors: Zhongshan Hospital Institute of Clinical Science, Fudan University, Shanghai Institute of Clinical Bioinformatics, Biomedical Research Center, Shanghai, China. Electronic address: xdwang@fuccb.com.
authors: Xiangdong
authors: X
authors: Wang
authors: Zhongshan Hospital Institute of Clinical Science, Fudan University, Shanghai Institute of Clinical Bioinformatics, Biomedical Research Center, Shanghai, China. Electronic address: zhang.yong@zs-hospital.sh.cn.
authors: Yong
authors: Y
authors: Zhang
mesh_terms: D000818:Animals; D018740:Genetic Heterogeneity; D006801:Humans; D008175:Lung Neoplasms / Q000175:diagnosis / Q000235:genetics* / Q000628:therapy; D008954:Models, Biological; D009077:Mucins / Q000737:chemistry / Q000378:metabolism*
chemical_list: D009077:Mucins
keywords: Diagnosis; Lung cancer; MUC; Therapy; Tumor heterogeneity