title: In-Vivo Proton Magnetic Resonance Spectroscopy of 2-Hydroxyglutarate in Isocitrate Dehydrogenase-Mutated Gliomas: A Technical Review for Neuroradiologists.
abstract: The diagnostic and prognostic potential of an onco-metabolite, 2-hydroxyglutarate (2HG) as a proton magnetic resonance spectroscopy (1H-MRS) detectable biomarker of the isocitrate dehydrogenase (IDH)-mutated (IDH-MT) gliomas has drawn attention of neuroradiologists recently. However, due to severe spectral overlap with background signals, quantification of 2HG can be very challenging. In this technical review for neuroradiologists, first, the biochemistry of 2HG and its significance in the diagnosis of IDH-MT gliomas are summarized. Secondly, various 1H-MRS methods used in the previous studies are outlined. Finally, wereview previous in vivo studies, and discuss the current status of 1H-MRS in the diagnosis of IDH-MT gliomas.
authors: Department of Radiology, Seoul National University Hospital, Seoul 03080, Korea.; Department of Biomedical Sciences, Seoul National University, Seoul 03087, Korea.; Institute of Radiation Medicine, Seoul National University Medical Research Center, Seoul 03080, Korea.
authors: Hyeonjin
authors: H
authors: Kim
authors: Department of Radiology, Seoul National University Hospital, Seoul 03080, Korea.
authors: Sungjin
authors: S
authors: Kim
authors: Department of Biomedical Sciences, Seoul National University, Seoul 03087, Korea.
authors: Hyeong Hun
authors: HH
authors: Lee
authors: Department of Biomedical Sciences, Seoul National University, Seoul 03087, Korea.
authors: Hwon
authors: H
authors: Heo
mesh_terms: D014408:Biomarkers, Tumor / Q000378:metabolism*; D001932:Brain Neoplasms / Q000175:diagnosis* / Q000235:genetics / Q000378:metabolism; D005910:Glioma / Q000175:diagnosis* / Q000235:genetics / Q000378:metabolism; D005977:Glutarates / Q000378:metabolism*; D006801:Humans; D007521:Isocitrate Dehydrogenase / Q000235:genetics*; D009154:Mutation; D011379:Prognosis; D066244:Proton Magnetic Resonance Spectroscopy / Q000379:methods*
chemical_list: D014408:Biomarkers, Tumor; D005977:Glutarates; C019417:alpha-hydroxyglutarate; D007521:Isocitrate Dehydrogenase
keywords: 2-hydroxyglutarate; Glioma; Isocitrate dehydrogenase; MRS; Magnetic resonance spectroscopy; Mutation; Proton