title: Mexicanolide-Type Limonoids from the Roots of Trichilia sinensis.
abstract: Four new mexicanolide-type limonoids 1-4, along with two known limonoids 5-6, were isolated from the ethanolic extracts of roots of the Traditional Chinese Medicine Trichilia sinensis. Their structures were unambiguously determined by analysis of spectroscopic data, including 1D and 2D NMR as well as MS, and by comparison with literature data. In addition, the acetylcholinesterase (AChE) inhibitory activity of compounds 1-6 was evaluated by the Ellman method. All these compounds showed weak AChE inhibitory activity, with the inhibition percentages ranging from 18.5% to 27.8%.
authors: Tropical Crops Genetic Resources Institute, Chinese Academy of Tropical Agricultural Sciences, Danzhou 571737, China. zhiwu19831113@163.com.|Key Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, China. zhiwu19831113@163.com.
authors: Shou-Bai
authors: SB
authors: Liu
authors: Key Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, China. meiwenli@itbb.org.cn.
authors: Wen-Li
authors: WL
authors: Mei
authors: Key Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, China. chenhuiqin@itbb.org.cn.
authors: Hui-Qin
authors: HQ
authors: Chen
authors: Key Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, China. guozhikai@itbb.org.cn.
authors: Zhi-Kai
authors: ZK
authors: Guo
authors: Key Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, China. daihaofu@itbb.org.cn.
authors: Hao-Fu
authors: HF
authors: Dai
authors: Tropical Crops Genetic Resources Institute, Chinese Academy of Tropical Agricultural Sciences, Danzhou 571737, China. 13807596560@163.com.
authors: Zhu-Nian
authors: ZN
authors: Wang
mesh_terms: D002800:Cholinesterase Inhibitors / Q000737:chemistry / Q000302:isolation & purification; D036701:Limonins / Q000737:chemistry / Q000302:isolation & purification; D009682:Magnetic Resonance Spectroscopy; D029582:Meliaceae / Q000737:chemistry*; D015394:Molecular Structure; D018517:Plant Roots / Q000737:chemistry*
chemical_list: D002800:Cholinesterase Inhibitors; D036701:Limonins; C554989:mexicanolide
keywords: AChE inhibitory activity; Trichilia sinensis; limonoids; meliaceae; mexicanolide-type