title: Choroidal thickness in non-neovascular versus neovascular age-related macular degeneration: a fellow eye comparative study.
abstract: To investigate the possible differences in choroidal thickness (CT) between non-neovascular (NNV) and neovascular (NV) age-related macular degeneration (AMD).
  
  
  
  A retrospective, observational chart review of consecutive patients diagnosed with NNV AMD in one eye and with NV AMD in the fellow eye was carried out. NNV AMD was classified into four subgroups according to the Beckman Initiative for Macular Research AMD Classification Committee Meeting. CT was manually assessed using enhanced depth imaging optical coherence tomography from 1500 µm nasal to 1500 µm temporal to the fovea. Parametric and non-parametric tests were used to compare quantitative variables, a χ2test was used to compare categorical variables and logistic regression was used to evaluate associations of CT with other variables of interest.
  
  
  
  In this study, 322 eyes from 161 patients were included and 102 (63.35%) were female and 59 (36.65%) were male, with a mean age of 80.80±8.45 years (range 58-99 years). Mean follow-up was 11.2±10.8 months (range 1-38 months). In NNV AMD eyes, the choroid was significantly thicker in the subfoveal and temporal regions of the macula, if compared with NV AMD fellow eyes. Differences in CT between NNV AMD and NV AMD fellow eyes were higher at earlier stages of NNV AMD.
  
  
  
  Subfoveal and temporal choroid was significantly thicker in NNV AMD compared with NV AMD fellow eyes. There was a significant choroidal thinning at advanced stages of NNV AMD.
authors: Retina Division, Stein Eye Institute, University of California Los Angeles, Los Angeles, California, USA.
authors: Andrea
authors: 0000-0003-2192-810X
authors: A
authors: Govetto
authors: Retinal Disorders and Ophthalmic Genetics Division, Stein Eye Institute, University of California Los Angeles, Los Angeles, California, USA.|Greater Los Angeles VA Healthcare Center, Los Angeles, California, USA.
authors: David
authors: D
authors: Sarraf
authors: Ophthalmology Department, Ramon y Cajal University Hospital, Madrid, Spain.
authors: Marta S
authors: MS
authors: Figueroa
authors: Ophthalmology Department, San Raffaele University Hospital, Milan, Italy.
authors: Luisa
authors: L
authors: Pierro
authors: Ophthalmology Department, Ramon y Cajal University Hospital, Madrid, Spain.
authors: Mario
authors: M
authors: Ippolito
authors: Retina Division, Stein Eye Institute, University of California Los Angeles, Los Angeles, California, USA.
authors: Grégoire
authors: G
authors: Risser
authors: Ophthalmology Department, San Raffaele University Hospital, Milan, Italy.
authors: Francesco
authors: F
authors: Bandello
authors: Retina Division, Stein Eye Institute, University of California Los Angeles, Los Angeles, California, USA.
authors: Jean Pierre
authors: JP
authors: Hubschman
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002829:Choroid / Q000473:pathology*; D020256:Choroidal Neovascularization / Q000175:diagnosis*; D005260:Female; D005451:Fluorescein Angiography / Q000379:methods*; D005500:Follow-Up Studies; D005654:Fundus Oculi; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012720:Severity of Illness Index; D013997:Time Factors; D041623:Tomography, Optical Coherence / Q000379:methods*; D014792:Visual Acuity; D057135:Wet Macular Degeneration / Q000175:diagnosis*
keywords: Choroid; Imaging; Macula