title: Association of Sjögrens Syndrome in Patients with Chronic Hepatitis Virus Infection: A Population-Based Analysis.
abstract: OBJECTIVE
  The association between Sjögren's syndrome (SS) and chronic hepatitis virus infection is inconclusive. Hepatitis B (HBV) and hepatitis C virus (HCV) infections are highly prevalent in Taiwan. We used a population-based case-control study to evaluate the associations between SS and HBV and HCV infections.
  
  
  METHODS
  We identified 9,629 SS patients without other concomitant autoimmune diseases and 38,516 sex- and age-matched controls without SS from the Taiwan National Health Insurance claims data between 2000 and 2011. We utilized multivariate logistic regression to estimate the odds ratios (ORs) and 95% confidence intervals (CIs) of the associations between SS and HBV and HCV infections. Sex- and age-specific (<55 and ≥55 years) risks of SS were evaluated.
  
  
  RESULTS
  The risk of SS was higher in patients with HCV than in those without chronic viral hepatitis (OR = 2.49, 95% CI = 2.16-2.86). Conversely, HBV infection was not associated with SS (OR = 1.10, 95% CI = 0.98-1.24). Younger HCV patients were at a higher risk for SS (<55 years: OR = 3.37, 95% CI = 2.62-4.35; ≥55 years: OR = 2.20, 95% CI = 1.84-2.62). Men with HCV were at a greater risk for SS (women: OR = 2.26, 95% CI = 1.94-2.63; men: OR = 4.22, 95% CI = 2.90-6.16). Only men with chronic HBV exhibited a higher risk of SS (OR = 1.61, 95% CI = 1.21-2.14).
  
  
  CONCLUSIONS
  HCV infection was associated with SS; however, HBV only associated with SS in men.
authors: School of Public Health, College of Public Health and Nutrition, Taipei Medical University, Taipei, Taiwan.|Department of Public Health, China Medical University, Taichung, Taiwan.
authors: Chih-Ching
authors: CC
authors: Yeh
authors: The Ph.D. Program for Translational Medicine, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan.
authors: Wen-Chang
authors: WC
authors: Wang
authors: Division of Allergy, Immunology, and Rheumatology, Far Eastern Memorial Hospital, Taipei, Taiwan.
authors: Chien-Sheng
authors: CS
authors: Wu
authors: Department of Health Services Administration, College of Public Health, China Medical University, Taichung, Taiwan.|Faculty of Public Health, Mahidol University, Bangkok, Thailand.
authors: Fung-Chang
authors: FC
authors: Sung
authors: School of Public Health, College of Public Health and Nutrition, Taipei Medical University, Taipei, Taiwan.|Department of Family Medicine, Taipei Medical University Hospital, Taipei, Taiwan.
authors: Chien-Tien
authors: CT
authors: Su
authors: Department of Family Medicine, School of Medicine, Taipei Medical University, Taipei, Taiwan.|Department of Family Medicine, Taipei Medical University, Wan Fang Hospital, Taipei, Taiwan.
authors: Ying-Hua
authors: YH
authors: Shieh
authors: Management Office for Health Data, China Medical University Hospital, Taichung, Taiwan.
authors: Shih-Ni
authors: SN
authors: Chang
authors: Department of Family Medicine, Taipei Medical University Hospital, Taipei, Taiwan.|Department of Family Medicine, School of Medicine, Taipei Medical University, Taipei, Taiwan.|Master Program in Long-Term Care, College of Nursing, Taipei Medical University, Taipei, Taiwan.|School of Medicine, Flinders University, Bedford Park, Australia.
authors: Fu-Hsiung
authors: FH
authors: Su
mesh_terms: D044466:Asian People / Q000706:statistics & numerical data; D016022:Case-Control Studies; D015897:Comorbidity; D005260:Female; D019694:Hepatitis B, Chronic / Q000453:epidemiology* / Q000208:ethnology; D019698:Hepatitis C, Chronic / Q000453:epidemiology* / Q000208:ethnology; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009313:National Health Programs / Q000706:statistics & numerical data*; D011159:Population Surveillance / Q000379:methods; D015995:Prevalence; D012307:Risk Factors; D012737:Sex Factors; D012859:Sjogren's Syndrome / Q000453:epidemiology* / Q000208:ethnology; D013624:Taiwan / Q000453:epidemiology