title: Histamine selectively potentiates acid-sensing ion channel 1a.
abstract: Although acid-sensitive ion channels (ASICs) play an important role in brain functions, the exact mechanism of their physiological activation remain unclear. A possible answer to the intriguing question is that some presently unknown endogenous ligand(s) positively modulate ASICs and enhance their responses to physiologically significant level. In the present work we found that histamine selectively potentiates ASIC1a homomers in CHO cells. Action of histamine was particularly pronounced at modest acidifications, which cause minor response. At these conditions micromolar concentrations of histamine have provided significant potentiation of ASIC1a response. We proposed that histamine and possibly some other endogenous amines can positively modulate ASICs functions.
authors: I.M. Sechenov Institute of Evolutionary Physiology and Biochemistry RAS, St. Petersburg, Russia.
authors: Elina I
authors: EI
authors: Nagaeva
authors: I.M. Sechenov Institute of Evolutionary Physiology and Biochemistry RAS, St. Petersburg, Russia.
authors: Tatiana B
authors: TB
authors: Tikhonova
authors: I.M. Sechenov Institute of Evolutionary Physiology and Biochemistry RAS, St. Petersburg, Russia; St Petersburg State University, Universitetskaya nab., 7-9, St. Petersburg, Russia.
authors: Lev G
authors: LG
authors: Magazanik
authors: I.M. Sechenov Institute of Evolutionary Physiology and Biochemistry RAS, St. Petersburg, Russia. Electronic address: denistikhonov2002@yahoo.com.
authors: Denis B
authors: DB
authors: Tikhonov
mesh_terms: D062565:Acid Sensing Ion Channels / Q000378:metabolism*; D000818:Animals; D016466:CHO Cells; D003412:Cricetulus; D005260:Female; D006632:Histamine / Q000494:pharmacology*; D010053:Ovary / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D018408:Patch-Clamp Techniques
chemical_list: D062565:Acid Sensing Ion Channels; D006632:Histamine
keywords: ASIC; Histamine; Potentiation; Selectivity