title: Plasma chitinase 3-like 1 is persistently elevated during first month after minimally invasive colorectal cancer resection.
abstract: OBJECTIVE
  To assess blood chitinase 3-like 1 (CHi3L1) levels for 2 mo after minimally invasive colorectal resection (MICR) for colorectal cancer (CRC).
  
  
  METHODS
  CRC patients in an Institutional Review Board approved data/plasma bank who underwent elective MICR for whom preoperative (PreOp), early postoperative (PostOp), and 1 or more late PostOp samples [postoperative day (POD) 7-27] available were included. Plasma CHi3L1 levels (ng/mL) were determined in duplicate by enzyme linked immunosorbent assay.
  
  
  RESULTS
  PreOp and PostOp plasma sample were available for 80 MICR cancer patients for the study. The median PreOp CHi3L1 level was 56.8 CI: 41.9-78.6 ng/mL (n = 80). Significantly elevated (P < 0.001) median plasma levels (ng/mL) over PreOp levels were detected on POD1 (667.7 CI: 495.7, 771.7; n = 79), POD 3 (132.6 CI: 95.5, 173.7; n = 76), POD7-13 (96.4 CI: 67.7, 136.9; n = 62), POD14-20 (101.4 CI: 80.7, 287.4; n = 22), and POD 21-27 (98.1 CI: 66.8, 137.4; n = 20, P = 0.001). No significant difference in plasma levels were noted on POD27-41.
  
  
  CONCLUSIONS
  Plasma CHi3L1 levels were significantly elevated for one month after MICR. Persistently elevated plasma CHi3L1 may support the growth of residual tumor and metastasis.
authors: H M C Shantha Kumara, David Gaita, Hiromichi Miyagaki, Xiaohong Yan, Sonali AC Hearth, Linda Njoh, Vesna Cekic, Richard L Whelan, Division of Colon and Rectal Surgery, Department of Surgery, Mount Sinai West Hospital, New York, NY 10019, United States.
authors: H M C
authors: HM
authors: Shantha Kumara
authors: H M C Shantha Kumara, David Gaita, Hiromichi Miyagaki, Xiaohong Yan, Sonali AC Hearth, Linda Njoh, Vesna Cekic, Richard L Whelan, Division of Colon and Rectal Surgery, Department of Surgery, Mount Sinai West Hospital, New York, NY 10019, United States.
authors: David
authors: D
authors: Gaita
authors: H M C Shantha Kumara, David Gaita, Hiromichi Miyagaki, Xiaohong Yan, Sonali AC Hearth, Linda Njoh, Vesna Cekic, Richard L Whelan, Division of Colon and Rectal Surgery, Department of Surgery, Mount Sinai West Hospital, New York, NY 10019, United States.
authors: Hiromichi
authors: H
authors: Miyagaki
authors: H M C Shantha Kumara, David Gaita, Hiromichi Miyagaki, Xiaohong Yan, Sonali AC Hearth, Linda Njoh, Vesna Cekic, Richard L Whelan, Division of Colon and Rectal Surgery, Department of Surgery, Mount Sinai West Hospital, New York, NY 10019, United States.
authors: Xiaohong
authors: X
authors: Yan
authors: H M C Shantha Kumara, David Gaita, Hiromichi Miyagaki, Xiaohong Yan, Sonali AC Hearth, Linda Njoh, Vesna Cekic, Richard L Whelan, Division of Colon and Rectal Surgery, Department of Surgery, Mount Sinai West Hospital, New York, NY 10019, United States.
authors: Sonali Ac
authors: SA
authors: Hearth
authors: H M C Shantha Kumara, David Gaita, Hiromichi Miyagaki, Xiaohong Yan, Sonali AC Hearth, Linda Njoh, Vesna Cekic, Richard L Whelan, Division of Colon and Rectal Surgery, Department of Surgery, Mount Sinai West Hospital, New York, NY 10019, United States.
authors: Linda
authors: L
authors: Njoh
authors: H M C Shantha Kumara, David Gaita, Hiromichi Miyagaki, Xiaohong Yan, Sonali AC Hearth, Linda Njoh, Vesna Cekic, Richard L Whelan, Division of Colon and Rectal Surgery, Department of Surgery, Mount Sinai West Hospital, New York, NY 10019, United States.
authors: Vesna
authors: V
authors: Cekic
authors: H M C Shantha Kumara, David Gaita, Hiromichi Miyagaki, Xiaohong Yan, Sonali AC Hearth, Linda Njoh, Vesna Cekic, Richard L Whelan, Division of Colon and Rectal Surgery, Department of Surgery, Mount Sinai West Hospital, New York, NY 10019, United States.
authors: Richard L
authors: RL
authors: Whelan
keywords: Chitinase 3-like 1; Colorectal cancer; Metastasis; Minimally inasive colorectal resection; Recurrence