title: Influence of gestational age and birth weight in neonatal cholesterol response to total parenteral nutrition.
abstract: Premature and critically ill infants receiving total parenteral nutrition (TPN) are at risk for dyslipidemia, and altered cholesterol levels in early life may contribute to later cardiovascular risk. Data regarding plasma cholesterol response to TPN in young infants are lacking.
  
  
  
  To determine the changes in plasma cholesterol levels during the first week of life in infants receiving TPN and a comparison group of infants who did not receive TPN during routine care.
  
  
  
  In a prospective, pilot cohort study, 38 neonates (30 TPN vs. 8 No-TPN) underwent serial blood sampling during the first week of life. Gas chromatography-mass spectrometry was used to measure cholesterol in plasma and TPN administered to study participants.
  
  
  
  Baseline cholesterol level was similar between groups. In contrast to infants who did not receive TPN, cholesterol levels during the first week of life were significantly higher than baseline in infants receiving TPN (maximum cholesterol response 34% vs. 103% change from baseline, No-TPN vs. TPN, respectively, P = .036). After adjusting for cumulative cholesterol received by infants receiving TPN, maximum cholesterol response remained inversely related to gestational age and birth weight (P < .05).
  
  
  
  Plasma cholesterol significantly increases during the first week of life in neonates receiving TPN. A higher cholesterol response was induced by TPN in infants of lower gestational age and birth weight.
authors: Department of Pediatrics, Medical College of Wisconsin, Milwaukee, WI, USA. Electronic address: hnghiem@mcw.edu.
authors: T Hang
authors: TH
authors: Nghiem-Rao
authors: Department of Pediatrics, Medical College of Wisconsin, Milwaukee, WI, USA.
authors: Allison F
authors: AF
authors: Dahlgren
authors: Department of Pediatrics, Albert Einstein College of Medicine, New York, NY, USA.
authors: Deepti
authors: D
authors: Kalluri
authors: Department of Pediatrics, Medical College of Wisconsin, Milwaukee, WI, USA.
authors: Yumei
authors: Y
authors: Cao
authors: Department of Pediatrics, Medical College of Wisconsin, Milwaukee, WI, USA.
authors: Pippa M
authors: PM
authors: Simpson
authors: Department of Medicine, Medical College of Wisconsin, Milwaukee, WI, USA; Zablocki Veterans Affairs Medical Center, Milwaukee, WI, USA.
authors: Shailendra B
authors: SB
authors: Patel
mesh_terms: D002784:Cholesterol / Q000097:blood*; D005260:Female; D005865:Gestational Age; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D010289:Parenteral Nutrition, Total / Q000009:adverse effects*; D047928:Premature Birth / Q000097:blood
chemical_list: D002784:Cholesterol
keywords: Cholesterol; Infants; Lipids; Neonates; Prematurity; Total parenteral nutrition