title: Giant cell-rich osteosarcoma of the parotid gland: An exceptionally rare entity at an unusual site.
abstract: Giant cell-rich osteosarcoma is a rare histologic variant of conventional osteosarcoma that affects mainly the extremities. Extraskeletal giant cell-rich osteosarcoma is therefore exceedingly rare. Here, we report the first case of this uncommon tumor involving the parotid gland in a 62-year-old male who presented with initial right jaw swelling. Radiologic work-up revealed a 6.2 cm mass involving the right parotid gland. Fine-needle aspiration cytology showed numerous multinucleated giant cells in a background of dyshesive epithelioid cells and rare clusters of spindle stromal cells, suspicious for malignancy. The subsequent excisional biopsy showed histopathologic features diagnostic for giant cell-rich osteosarcoma. Diagn. Cytopathol. 2016;44:1107-1111. © 2016 Wiley Periodicals, Inc.
authors: Department of Pathology and Laboratory Medicine, University of California, Davis Medical Center, Sacramento, California.
authors: Eric C
authors: EC
authors: Huang
authors: Department of Radiology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.
authors: Varand
authors: V
authors: Ghazikhanian
authors: Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.
authors: Xiaohua
authors: X
authors: Qian
mesh_terms: D044963:Biopsy, Fine-Needle; D015726:Giant Cells / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D012516:Osteosarcoma / Q000473:pathology*; D010307:Parotid Neoplasms / Q000473:pathology*; D035583:Rare Diseases / Q000473:pathology*; D017154:Stromal Cells / Q000473:pathology
keywords: cytology; fine-needle aspiration; giant cell-rich osteosarcoma; parotid gland