title: Early history of circular RNAs, children of splicing.
abstract: In this commentary we briefly summarize early work on circular RNAs derived from spliceosome mediated circularization. We highlight how this early work inspired work on the basic mechanisms of nuclear RNA splicing, the possible function of circular RNAs and the potential uses of circular RNAs as tools in biomedicine. Recent developments in the study of circular RNAs, summarized in this volume, have brought these questions back to the foreground.
authors: a Department of Chemistry , Illinois College , Jacksonville , Illinois , USA.
authors: Zvi
authors: Z
authors: Pasman
authors: b Department of Biochemistry and Molecular Biology , University of Texas Medical Branch , Galveston , Texas , USA.|c Programme of Emerging Infectious Diseases, Duke-NUS Medical School , Singapore.
authors: Mariano A
authors: MA
authors: Garcia-Blanco
mesh_terms: D005057:Eukaryotic Cells / Q000166:cytology / Q000378:metabolism; D005091:Exons; D049673:History, 20th Century; D049674:History, 21st Century; D006801:Humans; D007438:Introns; D008967:Molecular Biology / Q000266:history*; D009690:Nucleic Acid Conformation; D012313:RNA / Q000235:genetics* / Q000378:metabolism; D012322:RNA Precursors / Q000235:genetics* / Q000378:metabolism; D022821:RNA Splice Sites; D012326:RNA Splicing; D000079962:RNA, Circular; D017381:Spliceosomes / Q000378:metabolism / Q000648:ultrastructure
chemical_list: D012322:RNA Precursors; D022821:RNA Splice Sites; D000079962:RNA, Circular; D012313:RNA
keywords: Circular RNA; Sry; exon circularization; splice site approximation; spliceosome mediated splicing