title: Lymphadenectomy and health-related quality of life after oesophageal cancer surgery: a nationwide, population-based cohort study.
abstract: The purpose of this study was to clarify whether more extensive surgical lymph node resection during oesophageal cancer surgery influences patients' health-related quality of life (HRQOL).
  
  
  
  This was a nationwide Swedish population-based study.
  
  
  
  A total of 616 patients who underwent curatively intended oesophageal cancer surgery in 2001-2005 were followed up at 6 months and 5 years after surgery.
  
  
  
  HRQOL was assessed with the validated European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire Core-30 (EORTC QLQ-C30) and the oesophageal cancer-specific module (EORTC QLQ-OES18). The number of removed lymph nodes in relation to HRQOL was analysed using multivariable linear regression, providing mean score differences in HRQOL scores with 95% CIs. The results were adjusted for age, comorbidity, body mass index, tumour stage, tumour histology, postoperative complications and surgeon volume.
  
  
  
  The study included 382 and 136 patients who completed the EORTC questionnaires at 6 months and 5 years following surgery, respectively. In general, HRQOL remained stable over time, with only improvements in role function and appetite loss. A larger number of removed lymph nodes did not decrease the HRQOL measure at 6 months or 5 years after surgery.
  
  
  
  More extensive lymphadenectomy during oesophageal cancer surgery might not decrease patients' short-term or long-term HRQOL, but larger studies are needed to establish this potential lack of association.
authors: Unit of Surgical Care Science, Department of Molecular medicine and Surgery, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.
authors: Anna
authors: A
authors: Schandl
authors: Unit of Surgical Care Science, Department of Molecular medicine and Surgery, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.
authors: Asif
authors: A
authors: Johar
authors: Unit of Upper Gastrointestinal Research, Department of Molecular medicine and Surgery, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden Division of Cancer Studies, King's College London, and Guy's and St Thomas' NHS Foundation Trust, London, UK.
authors: Jesper
authors: J
authors: Lagergren
authors: Unit of Surgical Care Science, Department of Molecular medicine and Surgery, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.
authors: Pernilla
authors: P
authors: Lagergren
mesh_terms: D000368:Aged; D015897:Comorbidity; D004938:Esophageal Neoplasms / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D016014:Linear Models; D008197:Lymph Node Excision / Q000009:adverse effects; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D011183:Postoperative Complications / Q000209:etiology; D011788:Quality of Life; D011795:Surveys and Questionnaires; D013548:Sweden
keywords: HRQOL; Lymph node; oesophageal neoplasm