title: [The impairment of A-delta fibers in median nerve compression at the wrist, using the cutaneous silent period].
abstract: Carpal tunnel síndrome (CTS) is an entrapment neuropathy of the median nerve at the wrist, that leads to pain, paresthesia and painful dysesthesia. The electrophysiological diagnosis is based upon nerve conduction studies which evaluate thick nerve fibers. Our hypothesis is that there is an additional dysfunction of small fibers in CTS, which correlates with the degree of severity of the neuropathy. A retrospective study of 69 hands that belonged to 47 patients of both sexes (mean age 53.8, years, range 22-87) was performed, and, as a control group, 21 hands which corresponded to the asymptomatic side of those patients were evaluated. Motor and sensory conduction studies, as well as F-waves were performed to classify the neuropathy according to the degree of severity. Cutaneous silent period (CSP) was elicited in all hands. Mean onset latencies and durations of CSP were evaluated. Mean onset latencies were significantly prolonged in neuropathic hands (84.3 ± 16.3 msec) compared to asymptomatic hands (74.8 ± 11.6 msec) (p < 0.05). Mean latencies of the CSP were even prolonged (p < 0.05) in hands affected by a more severe neuropathy. In the 3 hands with most severe neuropathy, a CSP could not be elicited. In CTS an impairment of A-delta fibers was recorded through the CSP. The more severe the neuropathy is, the more impairment of A-delta fibers can be found. CSP may be assessed as a complement of motor and sensory nerve conduction studies in this neuropathy.
authors: Servicio de Neurofisiología Clínica, Hospital Alemán, Buenos Aires, Argentina. E-mail: jduarte@hospitalaleman.com.
authors: Juan M
authors: JM
authors: Duarte
authors: Servicio de Neurofisiología Clínica, Hospital Alemán, Buenos Aires, Argentina.
authors: Héctor M
authors: HM
authors: D'Onofrio
authors: Servicio de Neurofisiología Clínica, Hospital Alemán, Buenos Aires, Argentina.
authors: Juan Ignacio
authors: JI
authors: Rolón
authors: Servicio de Neurofisiología Clínica, Hospital Alemán, Buenos Aires, Argentina.
authors: Alicia C
authors: AC
authors: Bertotti
mesh_terms: D000328:Adult; D000369:Aged, 80 and over; D000704:Analysis of Variance; D002349:Carpal Tunnel Syndrome / Q000175:diagnosis* / Q000503:physiopathology; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008297:Male; D008475:Median Nerve; D008875:Middle Aged; D009412:Nerve Fibers / Q000502:physiology*; D009431:Neural Conduction / Q000502:physiology; D009460:Neurologic Examination / Q000379:methods; D012032:Refractory Period, Electrophysiological; D012189:Retrospective Studies; D018709:Statistics, Nonparametric; D055815:Young Adult
keywords: A-delta fibers; carpal tunnel syndrome; cutaneous silent period; dysesthesia; pain