title: Application and microbial preparation of D-valine.
abstract: D-Valine is an important organic chiral source and has extensive industrial application, which is used as intermediate for the synthesis of agricultural pesticides, semi-synthetic veterinary antibiotics and pharmaceutical drugs. Its derivatives have shown great activity in clinical use, such as penicillamine for the treatment of immune-deficiency diseases, and actinomycin D for antitumor therapy. Fluvalinate, a pyrethroid pesticide made from D-valine, is a broad-spectrum insecticide with low mammalian toxicity. Valnemulin, a semi-synthetic pleuromutilin derivative synthesized from D-valine, is an antibiotic for animals. Moreover, D-valine is also used in cell culture for selectively inhibiting fibroblasts proliferation. Due to its widespread application, D-valine is gaining more and more attention and some approaches for D-valine preparation have been investigated. In comparison with other approaches, microbial preparation of D-valine is more competitive and promising because of its high stereo selectivity, mild reaction conditions and environmental friendly process. So far, microbial preparation of D-valine can be mainly classified into three categories: microbial asymmetric degradation of DL-valine, microbial stereoselective hydrolysis of N-acyl-DL-valine by D-aminoacylase, and microbial specific hydrolysis of DL-5-isopropylhydantoin by D-hydantoinase coupled with D-carbamoylase. In this paper, the industrial application of D-valine and its microbial preparation are reviewed.
authors: School of Biological Engineering, Dalian Polytechnic University, Dalian, 116034, People's Republic of China.
authors: Ming
authors: M
authors: Chen
authors: School of Biological Engineering, Dalian Polytechnic University, Dalian, 116034, People's Republic of China.
authors: Chao
authors: C
authors: Shi
authors: College of Life Science, Dalian Nationalities University, Dalian, 116600, People's Republic of China.
authors: Jing
authors: J
authors: Zhao
authors: School of Biological Engineering, Dalian Polytechnic University, Dalian, 116034, People's Republic of China.
authors: Ziqing
authors: Z
authors: Gao
authors: School of Biological Engineering, Dalian Polytechnic University, Dalian, 116034, People's Republic of China. zhangcz@dlpu.edu.cn.
authors: Chunzhi
authors: C
authors: Zhang
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D001419:Bacteria / Q000378:metabolism*; D002478:Cells, Cultured / Q000187:drug effects; D004224:Diterpenes / Q000494:pharmacology; D004345:Drug Industry; D006801:Humans; D007306:Insecticides / Q000494:pharmacology; D009570:Nitriles / Q000494:pharmacology; D011722:Pyrethrins / Q000494:pharmacology; D014633:Valine / Q000031:analogs & derivatives* / Q000378:metabolism*
chemical_list: D000900:Anti-Bacterial Agents; D004224:Diterpenes; D007306:Insecticides; D009570:Nitriles; D011722:Pyrethrins; C117845:valnemulin; C034227:fluvalinate; D014633:Valine
keywords: Asymmetric hydrolysis; Chiral source; D-Valine; Industrial application; Microbial preparation