title: Direct Electron Detectors.
abstract: Direct electron detectors have played a key role in the recent increase in the power of single-particle electron cryomicroscopy (cryoEM). In this chapter, we summarize the background to these recent developments, give a practical guide to their optimal use, and discuss future directions.
authors: MRC Laboratory of Molecular Biology, Cambridge, United Kingdom.
authors: G
authors: G
authors: McMullan
authors: MRC Laboratory of Molecular Biology, Cambridge, United Kingdom.
authors: A R
authors: AR
authors: Faruqi
authors: MRC Laboratory of Molecular Biology, Cambridge, United Kingdom. Electronic address: rh15@mrc-lmb.cam.ac.uk.
authors: R
authors: R
authors: Henderson
mesh_terms: D001426:Bacterial Proteins / Q000648:ultrastructure; D015374:Biosensing Techniques / Q000266:history / Q000295:instrumentation / Q000379:methods*; D020285:Cryoelectron Microscopy / Q000266:history / Q000295:instrumentation / Q000379:methods*; D004583:Electrons; D004926:Escherichia coli / Q000737:chemistry / Q000201:enzymology; D049673:History, 20th Century; D049674:History, 21st Century; D009010:Monte Carlo Method; D012825:Silicon / Q000737:chemistry; D012984:Software; D001616:beta-Galactosidase / Q000648:ultrastructure
chemical_list: D001426:Bacterial Proteins; D001616:beta-Galactosidase; D012825:Silicon
keywords: CMOS; DDD; DQE; Direct Electron; Electron microscopy; FEI; Gatan; MTF; Sensor; cryoEM