title: [Influence of non-alcoholic fatty liver disease on geno- and immunotoxic alterations of peripheric blood lymphocytes of oil refinery workers].
abstract: BACKGROUND
  More than half of the Hungarian population is overweight or obese, therefore, non-alcoholic fatty liver is a common problem. According to clinical experience, 20-30% of fatty liver cases is not related to alcohol, but can be linked to diabetes, obesity or metabolic syndrome.
  
  
  OBJECTIVE
  The authors studied the correlation between genotoxicity, immuntoxicity and non-alcoholic fatty liver among oil refinery workers.
  
  
  METHODS
  During this genotoxicological monitoring study the data of 107 exposed were compared to 67 controls.
  
  
  RESULTS
  36% of oil refinery workers had non-alcoholic fatty liver, while none of the selected, non-exposed controls had this abnormality. Chromosomal aberrations were elevated from 1.6% to 3.75% in the exposed group, immunotoxicological parameters were also changed, and CD71 positive B-cell ratio increased especially among subjects having non-alcoholic fatty liver.
  
  
  CONCLUSIONS
  Non-alcoholic fatty liver can negatively influence the genotoxic effects of environmental hazards in workplaces. In the future this condition should be considered during risk assessment. Orv. Hetil., 2016, 157(35), 1394-1402.
authors: Népegészségtani Intézet, Semmelweis Egyetem, Általános Orvostudományi Kar Budapest, Nagyvárad tér 4., 1096.|Országos Közegészségügyi Központ Országos Kémiai Biztonsági Igazgatósága Budapest.
authors: Anna
authors: A
authors: Tompa
authors: Országos Közegészségügyi Központ Országos Kémiai Biztonsági Igazgatósága Budapest.
authors: Anna
authors: A
authors: Biró
authors: Népegészségtani Intézet, Semmelweis Egyetem, Általános Orvostudományi Kar Budapest, Nagyvárad tér 4., 1096.
authors: Péter
authors: P
authors: Balázs
authors: Országos Közegészségügyi Központ Országos Kémiai Biztonsági Igazgatósága Budapest.
authors: Mátyás
authors: M
authors: Jakab
mesh_terms: D000328:Adult; D002617:Chemical Industry; D002869:Chromosome Aberrations / Q000139:chemically induced*; D005260:Female; D006801:Humans; D016130:Immunophenotyping; D008297:Male; D008875:Middle Aged; D009504:Neutrophils / Q000276:immunology; D065626:Non-alcoholic Fatty Liver Disease / Q000139:chemically induced* / Q000276:immunology; D009784:Occupational Diseases / Q000209:etiology*; D016273:Occupational Exposure / Q000009:adverse effects*; D015995:Prevalence
keywords: DNA-repair; DNS-repair; chromosomes; fatty liver; foglalkozás-egészségügy; genotoxicology monitoring; géntoxikológiai monitor; immune toxicity; immuntoxikológia; kromoszóma; occupational health; zsírmáj