title: A novel porous aspirin-loaded (GO/CTS-HA)n nanocomposite films: Synthesis and multifunction for bone tissue engineering.
abstract: A novel porous graphene oxide (GO)/chitosan (CTS)-hydroxyapatite (HA) nanocomposite film was successfully prepared for the first time by combining layer-by-layer (LBL) assembly technology with biomimetic mineralization method. The LBL technology was used to control the thickness of film as well as induce the biomimetic mineralization of biocompatible HA. The obtained (GO/CTS-HA)n film provided ideal platform for the proliferation of mouse mesenchymal stem cells (mMSCs). The pore size in the film is about 300nm, and the porous architecture made the film have high aspirin loading efficiency. Also the accumulated loading dosage could be adjusted by the film thickness, and the sustained release of aspirin could ensure well anti-inflammatory effect. The above advantages may alleviate the pain of patients and give the better environment for bone regeneration. This multifunctional aspirin-loaded (GO/CTS-HA)n film provided an inspiration for the synthesis of novel porous inorganic/biomacromolecule nanocomposite films as the biocoatings applied in bone tissue engineering.
authors: School of Chemistry and Chemical Engineering, Collaborative Innovation Center of Modern Bio-Manufacture, Anhui University, Hefei 230601, PR China.
authors: Mingxiang
authors: M
authors: Ji
authors: Stomatologic Hospital & College, Anhui Medical University, Key Lab. of Oral Diseases Research of Anhui Province, Hefei 230032, PR China.
authors: Han
authors: H
authors: Li
authors: School of Chemistry and Chemical Engineering, Collaborative Innovation Center of Modern Bio-Manufacture, Anhui University, Hefei 230601, PR China.
authors: Hailin
authors: H
authors: Guo
authors: School of Chemistry and Chemical Engineering, Collaborative Innovation Center of Modern Bio-Manufacture, Anhui University, Hefei 230601, PR China.
authors: Anjian
authors: A
authors: Xie
authors: School of Chemistry and Chemical Engineering, Collaborative Innovation Center of Modern Bio-Manufacture, Anhui University, Hefei 230601, PR China.
authors: Shaohua
authors: S
authors: Wang
authors: School of Chemistry and Chemical Engineering, Collaborative Innovation Center of Modern Bio-Manufacture, Anhui University, Hefei 230601, PR China.
authors: Fangzhi
authors: F
authors: Huang
authors: School of Chemistry and Chemical Engineering, Collaborative Innovation Center of Modern Bio-Manufacture, Anhui University, Hefei 230601, PR China.
authors: Shikuo
authors: S
authors: Li
authors: School of Chemistry and Chemical Engineering, Collaborative Innovation Center of Modern Bio-Manufacture, Anhui University, Hefei 230601, PR China. Electronic address: s_yuhua@163.com.
authors: Yuhua
authors: Y
authors: Shen
authors: Stomatologic Hospital & College, Anhui Medical University, Key Lab. of Oral Diseases Research of Anhui Province, Hefei 230032, PR China. Electronic address: hejiacai@163.com.
authors: Jiacai
authors: J
authors: He
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage*; D058633:Antipyretics / Q000008:administration & dosage; D001241:Aspirin / Q000008:administration & dosage*; D002460:Cell Line; D049109:Cell Proliferation; D048271:Chitosan / Q000737:chemistry*; D003692:Delayed-Action Preparations / Q000737:chemistry; D017886:Durapatite / Q000737:chemistry*; D006108:Graphite / Q000737:chemistry*; D059630:Mesenchymal Stem Cells / Q000166:cytology*; D051379:Mice; D053761:Nanocomposites / Q000737:chemistry* / Q000648:ultrastructure; D010087:Oxides / Q000737:chemistry; D016062:Porosity; D023822:Tissue Engineering; D054457:Tissue Scaffolds / Q000737:chemistry
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D058633:Antipyretics; D003692:Delayed-Action Preparations; D010087:Oxides; D006108:Graphite; D048271:Chitosan; D017886:Durapatite; D001241:Aspirin
keywords: Biomimetic mineralization; Bone tissue engineering; Graphene oxide/chitosan-hydroxyapatite; Layer-by-layer assembly technology; Porous nanocomposite film