title: A marginal structural model for recurrent events in the presence of time-dependent confounding: non-specific effects of vaccines on child hospitalisations.
abstract: Using a Danish register-based study on childhood vaccination and hospitalisation as motivation, a marginal structural model for recurrent events is studied. The model addresses a number of challenges which may be seen more generally in large register-based cohort studies. One is to adjust for a time-dependent confounder when studying the effect of a time-varying exposure on a recurrent event based on an analysis in continuous time. Another is to report results via a measure which is easy to interpret and communicate even though quite elaborate treatment regimes are considered. Lastly, the implementation of continuously updated weights implies a substantial computationally demanding workload. Copyright © 2016 John Wiley & Sons, Ltd.
authors: Section of Biostatistics, University of Copenhagen. akje@biostat.ku.dk.|Research Center for Vitamins and Vaccines (CVIVA), Bandim Health Project, Statens Serum Institut, Copenhagen, Denmark. akje@biostat.ku.dk.
authors: Aksel K G
authors: AK
authors: Jensen
authors: Research Center for Vitamins and Vaccines (CVIVA), Bandim Health Project, Statens Serum Institut, Copenhagen, Denmark.|OPEN, University of Southern Denmark/Odense University Hospital.
authors: Henrik
authors: H
authors: Ravn
authors: Research Center for Vitamins and Vaccines (CVIVA), Bandim Health Project, Statens Serum Institut, Copenhagen, Denmark.
authors: Signe
authors: S
authors: Sørup
authors: Section of Biostatistics, University of Copenhagen.
authors: Per
authors: P
authors: Andersen
mesh_terms: D002648:Child; D015331:Cohort Studies; D003718:Denmark; D006760:Hospitalization; D006801:Humans; D064789:Immunity, Heterologous; D015233:Models, Statistical; D012042:Registries; D014612:Vaccines
chemical_list: D014612:Vaccines
keywords: continuously updated weights; marginal structural model; multi-state model; non-specific effects of vaccination; recurrent events