title: Hypotensive, cardiodepressant, and vasorelaxant activities of black currant (Ribes nigrum 'Ben Sarek') juice.
abstract: The aim of this study was to evaluate the effects of black currant (Ribes nigrum L. 'Ben Sarek') juice on the blood pressure and frequency of cardiac contractions, as well as vasomotor responses of rat aortic rings. Arterial blood pressure was measured directly from the carotid artery in the anaesthetized rabbits. The aortic rings were pre-contracted with KCl (80 mmol·L-1), after which black currant juice was added. An intravenous injection of black currant juice (0.33-166.5 mg·kg-1) induced a significant and dose-dependent decrease of rabbit arterial blood pressure and heart rate. The black currant juice decreased arterial blood pressure of rabbit by 22.33% ± 3.76% (p < 0.05) and heart rate by 17.18% ± 2.93% (p < 0.05). Cumulative addition of the black currant juice (0.01-3 mg·mL-1) inhibited concentration-dependent KCl induced contractions of the isolated rat aorta. The black currant juice, at the concentration of 3 mg·mL-1, caused a maximum relaxation of 21.75% ± 3.15% (p < 0.05). These results demonstrate that black currant juice can induce hypotension. The hypotensive effect of the black currant may occur as the consequence of its inhibitory activity on the rate of heart contraction and vasorelaxant effects.
authors: a Department of Physiology, Faculty of Medicine, University of Niš, Boulevard Zorana Ðinđića 81, Niš, Serbia.
authors: Suzana
authors: S
authors: Branković
authors: b Department of Pharmacy, Faculty of Medicine, University of Niš, Boulevard Zorana Ðinđića 81, Niš, Serbia.
authors: Bojana
authors: B
authors: Miladinović
authors: a Department of Physiology, Faculty of Medicine, University of Niš, Boulevard Zorana Ðinđića 81, Niš, Serbia.
authors: Mirjana
authors: M
authors: Radenković
authors: a Department of Physiology, Faculty of Medicine, University of Niš, Boulevard Zorana Ðinđića 81, Niš, Serbia.
authors: Marija
authors: M
authors: Gočmanac Ignjatović
authors: b Department of Pharmacy, Faculty of Medicine, University of Niš, Boulevard Zorana Ðinđića 81, Niš, Serbia.
authors: Milica
authors: M
authors: Kostić
authors: c Institute for Medicinal Plants Research "Josif Pančić", Tadeuša Košćuška 1, Belgrade, Serbia.
authors: Katarina
authors: K
authors: Šavikin
authors: b Department of Pharmacy, Faculty of Medicine, University of Niš, Boulevard Zorana Ðinđića 81, Niš, Serbia.
authors: Dušanka
authors: D
authors: Kitić
keywords: activité de dépression de la fonction cardiaque; activité hypotensive; black currant; cardiodepressant activity; cassis; hypotensive activity; juices; jus; vasorelaxation