title: Intratumor and circulating clonal heterogeneity shape the basis of precision breast cancer therapy.
authors: Centre for Biosystems & Genomic Network Medicine, University of Ioannina, Ioannina, Greece.|Department of Surgery, 'G Hatzikosta' General Hospital, Ioannina, Greece.
authors: Demosthenes E
authors: DE
authors: Ziogas
authors: Department of Surgery, METAXA Cancer Memorial Hospital, Botosi 51, TK 18535, Piraeus, Greece.
authors: John
authors: J
authors: Spiliotis
authors: Department of Plastic Surgery, Ioannina University School of Medicine, Ioannina, Greece.
authors: Efstathios G
authors: EG
authors: Lykoudis
authors: First Department of Propaedeutic Surgery, Hippocration Hospital, Athens Medical School, National & Kapodistrian University of Athens, Athens 11525, Greece.
authors: Georgios C
authors: GC
authors: Zografos
authors: Centre for Biosystems & Genomic Network Medicine, University of Ioannina, Ioannina, Greece.|Department of Surgery, Ioannina University Hospital, Ioannina, Greece.|Biomedical Research Foundation of the Academy of Athens (BRFAA), Athens, Greece.
authors: Dimitrios H
authors: DH
authors: Roukos
mesh_terms: D005260:Female; D006801:Humans; D001943:Breast Neoplasms / Q000235:genetics / Q000473:pathology / Q000628:therapy; D003131:Combined Modality Therapy; D018450:Disease Progression; D018740:Genetic Heterogeneity; D023281:Genomics / Q000379:methods; D059014:High-Throughput Nucleotide Sequencing; D009360:Neoplastic Cells, Circulating / Q000378:metabolism / Q000473:pathology; D057285:Precision Medicine
keywords: breast cancer; clonal diversity; intratumor heterogeneity; next-generation sequencing; therapy