title: Hypereosinophilic syndrome presenting with multiple organ infiltration and deep venous thrombosis: A case report and literature review.
abstract: BACKGROUND
  Hypereosinophilic syndrome (HES) can be fatal, particularly when eosinophils infiltrate vital organs and/or if extensive thrombosis develops. However there are no standard recommendations for the use of anticoagulant therapy of HES in the setting of thrombosis.
  
  
  METHODS
  We herein present a case of a 46-year-old female who presented with marked peripheral eosinophilia with symptoms of multi-organ infiltration and extensive deep venous thrombosis (DVT). In this case, evaluation was carried out before the diagnosis was established, and timely standard-dose corticosteroids combined with a new oral anticoagulant (NOAC) therapy were carried out.
  
  
  RESULTS
  These measures resulted in a rapid response and long-term disease control.
  
  
  CONCLUSIONS
  Although there are no data to support which anticoagulant is preferred in this setting, this case indicates that the new oral anticoagulants may play an important role in the treatment of thrombosis in HES.
authors: Hematology section, Cancer Center, the First Hospital of Jilin University Department of Urology, The First Hospital of Jilin University, Changchun, Jilin, China Division of Hematology, Mayo Clinic, Rochester, Minnesota, USA Second Department of Cardiology, The First Hospital of Qiqihaer Hospital, Qiqihaer, Heilongjiang, China.
authors: Su-Jun
authors: SJ
authors: Gao
authors: Wei
authors: W
authors: Wei
authors: Jiang-Tao
authors: JT
authors: Chen
authors: Ye-Hui
authors: YH
authors: Tan
authors: Cheng-Bao
authors: CB
authors: Yu
authors: Mark Robert
authors: MR
authors: Litzow
authors: Qiu-Ju
authors: QJ
authors: Liu
mesh_terms: D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D065427:Factor Xa Inhibitors / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D017681:Hypereosinophilic Syndrome / Q000150:complications* / Q000188:drug therapy* / Q000473:pathology; D007668:Kidney / Q000473:pathology; D008099:Liver / Q000473:pathology; D008875:Middle Aged; D017713:Platelet Transfusion; D011239:Prednisolone / Q000627:therapeutic use*; D000069552:Rivaroxaban / Q000627:therapeutic use*; D013909:Thorax / Q000473:pathology; D020246:Venous Thrombosis / Q000188:drug therapy* / Q000209:etiology*
chemical_list: D000893:Anti-Inflammatory Agents; D065427:Factor Xa Inhibitors; D000069552:Rivaroxaban; D011239:Prednisolone