title: Impact of pneumococcal conjugate vaccination: a retrospective study of hospitalization for pneumonia in North-East Italy.
abstract: Pneumonia remains a common reason for hospitalizing infants and the elderly worldwide, and streptococcal infection is often responsible. The aim of this study was to assess the burden of pneumonia in a large general population.
  
  
  
  All pneumonia-related hospitalizations from 2004 to 2013 in north-east Italy were identified from the hospital records with a first-listed diagnosis on discharge of bacterial pneumonia, or a first-listed diagnosis on discharge of meningitis, septicemia or empyema associated with a secondary diagnosis of bacterial pneumonia. We identified major comorbidities, calculated agespecific case-fatality rates (CFR), and estimated the related cost to the health care system.
  
  
  
  Of the 125,722 hospitalizations identified, 96.9% were cases of pneumonia, 2.4% of septicemia, 0.4% of meningitis, and 0.3% of empyema; 75.3% of hospitalizations involved ≥ 65-yearolds. The overall CFR was 12.4%, and it increased with age, peaking in people over 80 (19.6%). The mean annual pneumonia-associated hospitalization rate was 204.6 per 100,000 population, and it peaked in 0- to 4-year-old children (325.6 per 100,000 in males, 288.9 per 100,000 in females), and adults over 65 (844.9 per 100,000 in males, 605.7 per 100,000 in females). Hospitalization rates dropped over the years for the 0-4 year-olds, and rose for people over 80. The estimated overall annual cost of these pneumonia-related hospitalizations was approximately € 41 million.
  
  
  
  This study shows that the burden on resources for pneumonia-related hospitalization is an important public health issue. Prevention remains the most valuable tool for containing pneumonia, and vaccination strategies can help in the primary prevention of infection, possibly reducing the number of cases in all age groups.
authors: Institute of Hygiene, University of Padua, Italy;
authors: V
authors: V
authors: Baldo
authors: Institute of Hygiene, University of Padua, Italy;
authors: S
authors: S
authors: Cocchio
authors: EuroHealth Net, Friuli Venezia Giulia Region Health Directorate, Italy;
authors: T
authors: T
authors: Gallo
authors: Institute of Hygiene, University of Padua, Italy;
authors: P
authors: P
authors: Furlan
authors: EuroHealth Net, Friuli Venezia Giulia Region Health Directorate, Italy;
authors: E
authors: E
authors: Clagnan
authors: EuroHealth Net, Friuli Venezia Giulia Region Health Directorate, Italy;
authors: S
authors: S
authors: Del Zotto
authors: EuroHealth Net, Veneto Region Health Directorate, Italy.
authors: M
authors: M
authors: Saia
authors: Institute of Hygiene, University of Padua, Italy;
authors: C
authors: C
authors: Bertoncello
authors: Institute of Hygiene, University of Padua, Italy;
authors: A
authors: A
authors: Buja
authors: Institute of Hygiene, University of Padua, Italy;
authors: T
authors: T
authors: Baldovin
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D002675:Child, Preschool; D005260:Female; D006760:Hospitalization; D006801:Humans; D007223:Infant; D007558:Italy; D008297:Male; D008875:Middle Aged; D022242:Pneumococcal Vaccines / Q000627:therapeutic use*; D011014:Pneumonia / Q000517:prevention & control / Q000628:therapy*; D012189:Retrospective Studies; D014611:Vaccination; D055815:Young Adult
chemical_list: D022242:Pneumococcal Vaccines
keywords: Epidemiology; Hospitalization; PCV; Pneumonia; Streptococcus Pneumoniae; Vaccination