title: Arterial stiffness &Sri Lankan chronic kidney disease of unknown origin.
abstract: Chronic kidney disease (CKD) is common and independently associated with cardiovascular disease (CVD). Arterial stiffness contributes to CVD risk in CKD. In many developing countries a considerable proportion of CKD remains unexplained, termed CKDu. We assessed arterial stiffness in subjects with Sri Lankan CKDu, in matched controls without CKD and in those with defined CKD. Aortic blood pressure (BP), pulse wave velocity (PWV) and augmentation index (AIx) were assessed in 130 subjects (50 with CKDu, 45 with CKD and 35 without CKD) using the validated TensioMed™ Arteriograph monitor. Brachial and aortic BP was lower in controls than in CKDu and CKD subjects but no different between CKDu and CKD. Controls had a lower PWV compared to subjects with CKDu and CKD. Despite equivalent BP and renal dysfunction, CKDu subjects had a lower PWV than those with CKD (8.7 ± 1.5 vs. 9.9 ± 2.2 m/s, p < 0.01). Excluding diabetes accentuated the differences in PWV seen between groups (controls vs. CKDu vs. CKD: 6.7 ± 0.9 vs. 8.7 ± 1.5 vs. 10.4 ± 1.5 m/s, p < 0.001 for all). Sri Lankan CKDu is associated with less arterial stiffening than defined causes of CKD. Whether this translates to lower cardiovascular morbidity and mortality long term is unclear and should be the focus of future studies.
authors: University/British Heart Foundation Centre of Research Excellence, University of Edinburgh, The Queen's Medical Research Institute, 47 Little France Crescent, Edinburgh, EH16 4TJ, UK.|South Asian Clinical Toxicology Research Collaboration (SACTRC), University of Peradeniya, UK.
authors: Fiona
authors: F
authors: Gifford
authors: University/British Heart Foundation Centre of Research Excellence, University of Edinburgh, The Queen's Medical Research Institute, 47 Little France Crescent, Edinburgh, EH16 4TJ, UK.
authors: Robert
authors: R
authors: Kimmitt
authors: Sri Jayewardenepura General Hospital, Nugegoda, Sri Lanka.
authors: Chula
authors: C
authors: Herath
authors: University/British Heart Foundation Centre of Research Excellence, University of Edinburgh, The Queen's Medical Research Institute, 47 Little France Crescent, Edinburgh, EH16 4TJ, UK.
authors: David J
authors: DJ
authors: Webb
authors: University/British Heart Foundation Centre of Research Excellence, University of Edinburgh, The Queen's Medical Research Institute, 47 Little France Crescent, Edinburgh, EH16 4TJ, UK.
authors: Vanessa
authors: V
authors: Melville
authors: Faculty of Medicine and Applied Sciences, Rajarata University of Sri Lanka.
authors: Sisira
authors: S
authors: Siribaddana
authors: University/British Heart Foundation Centre of Research Excellence, University of Edinburgh, The Queen's Medical Research Institute, 47 Little France Crescent, Edinburgh, EH16 4TJ, UK.|South Asian Clinical Toxicology Research Collaboration (SACTRC), University of Peradeniya, UK.
authors: Michael
authors: M
authors: Eddleston
authors: University/British Heart Foundation Centre of Research Excellence, University of Edinburgh, The Queen's Medical Research Institute, 47 Little France Crescent, Edinburgh, EH16 4TJ, UK.|Department of Renal Medicine, Royal Infirmary of Edinburgh, UK.
authors: Neeraj
authors: N
authors: Dhaun
mesh_terms: D001794:Blood Pressure / Q000502:physiology; D003920:Diabetes Mellitus / Q000503:physiopathology; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D063177:Pulse Wave Analysis; D013188:Sri Lanka; D013599:Systole / Q000502:physiology; D059289:Vascular Stiffness / Q000502:physiology*