title: Polygenic Models for Risk Prediction in Human Genetics.
abstract: After a brief discussion and evaluation of Fisher's additive polygenic inheritance model, a few other approaches to polygenic inheritance are discussed, notably the polygenic threshold model. A literature review of applications of such models in human genetics is presented, and a simple approach, based on a finite polygenic model, is developed in detail. The fit of the model to recurrence risks in schizophrenia is discussed.
authors: Jurg
authors: J
authors: Ott
mesh_terms: D005826:Genetics, Medical / Q000379:methods*; D006801:Humans; D008957:Models, Genetic; D020412:Multifactorial Inheritance / Q000235:genetics; D018570:Risk Assessment; D012559:Schizophrenia / Q000235:genetics