title: Lipid lowering activity of novel N-(benzoylphenyl)pyridine-3-carboxamide derivatives in Triton WR-1339-induced hyperlipidemic rats.
abstract: BACKGROUND
  Dyslipidemia is a major risk factor for the development of cardiovascular diseases. Many dyslipidemic patients do not achieve their target lipid levels with the currently available medications, and most of them may experience many side effects.
  
  
  OBJECTIVE
  The present work aimed toward identifying a new class of novel nicotinic acid-carboxamide derivatives as promising antihyperlipidemic compounds.
  
  
  METHODS
  Six novel N-(benzoylphenyl)pyridine-3-carboxamide derivatives were synthesized using acid chloride pathways. All structures were confirmed using1H-NMR,13C-NMR, IR, and HRMS. The evaluation of biological activity was conducted using Triton WR-1339-induced hyperlipidemic rats model.
  
  
  RESULTS
  This study revealed that some of the newly synthesized novel N-(benzoylphenyl)pyridine-3-carboxamide derivatives mainly C4 and C6 possessed significant antihyperlipidemic activities on lipid components TG and TC (p value <0.05).
  
  
  CONCLUSIONS
  This research opens the door for new potential antihyperlipidemic compounds derived from nicotinic acid that need further optimization of their biological activities.
authors: a Faculty of Pharmacy , The University of Jordan , Amman , Jordan and.
authors: Rana
authors: R
authors: Abu Farha
authors: a Faculty of Pharmacy , The University of Jordan , Amman , Jordan and.
authors: Yasser
authors: Y
authors: Bustanji
authors: a Faculty of Pharmacy , The University of Jordan , Amman , Jordan and.
authors: Yusuf
authors: Y
authors: Al-Hiari
authors: b Faculty of Pharmacy , Alzaytoonah University of Jordan , Amman , Jordan.
authors: Tariq
authors: T
authors: Al-Qirim
authors: b Faculty of Pharmacy , Alzaytoonah University of Jordan , Amman , Jordan.
authors: Ghassan
authors: G
authors: Abu Shiekha
authors: a Faculty of Pharmacy , The University of Jordan , Amman , Jordan and.
authors: Rabab
authors: R
authors: Albashiti
mesh_terms: D000818:Animals; D065067:Antihyperkalemic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D004195:Disease Models, Animal; D006949:Hyperlipidemias / Q000139:chemically induced* / Q000188:drug therapy*; D008055:Lipids / Q000037:antagonists & inhibitors* / Q000097:blood; D008297:Male; D015394:Molecular Structure; D011092:Polyethylene Glycols; D011725:Pyridines / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D065067:Antihyperkalemic Agents; D008055:Lipids; C000614258:N-(benzoylphenyl)pyridine-3-carboxamide; D011725:Pyridines; D011092:Polyethylene Glycols; C016811:tyloxapol
keywords: Hyperlipidemia; Triton WR-1339; nicotinic acid