title: Data on gene and protein expression changes induced by apabetalone (RVX-208) in ex vivo treated human whole blood and primary hepatocytes.
abstract: Apabetalone (RVX-208) inhibits the interaction between epigenetic regulators known as bromodomain and extraterminal (BET) proteins and acetyl-lysine marks on histone tails. Data presented here supports the manuscript published in Atherosclerosis "RVX-208, a BET-inhibitor for Treating Atherosclerotic Cardiovascular Disease, Raises ApoA-I/HDL and Represses Pathways that Contribute to Cardiovascular Disease" (Gilham et al., 2016) [1]. It shows that RVX-208 and a comparator BET inhibitor (BETi) JQ1 increase mRNA expression and production of apolipoprotein A-I (ApoA-I), the main protein component of high density lipoproteins, in primary human and African green monkey hepatocytes. In addition, reported here are gene expression changes from a microarray-based analysis of human whole blood and of primary human hepatocytes treated with RVX-208.
authors: Resverlogix Corp., Calgary, Canada.
authors: Sylwia
authors: S
authors: Wasiak
authors: Resverlogix Corp., Calgary, Canada.
authors: Dean
authors: D
authors: Gilham
authors: Resverlogix Corp., Calgary, Canada.
authors: Laura M
authors: LM
authors: Tsujikawa
authors: Resverlogix Corp., Calgary, Canada.
authors: Christopher
authors: C
authors: Halliday
authors: Resverlogix Corp., Calgary, Canada.
authors: Karen
authors: K
authors: Norek
authors: Resverlogix Corp., Calgary, Canada.
authors: Reena G
authors: RG
authors: Patel
authors: Resverlogix Corp., Calgary, Canada.
authors: Kevin G
authors: KG
authors: McLure
authors: Resverlogix Corp., San Francisco, USA.
authors: Peter R
authors: PR
authors: Young
authors: Resverlogix Corp., San Francisco, USA.
authors: Allan
authors: A
authors: Gordon
authors: Resverlogix Corp., Calgary, Canada.
authors: Ewelina
authors: E
authors: Kulikowski
authors: Resverlogix Corp., San Francisco, USA.
authors: Jan
authors: J
authors: Johansson
authors: Resverlogix Corp., San Francisco, USA.
authors: Michael
authors: M
authors: Sweeney
authors: Resverlogix Corp., Calgary, Canada.
authors: Norman C
authors: NC
authors: Wong
keywords: African green monkey; ApoA-I; Apolipoprotein A-I; BET inhibitor; BET proteins; Bromodomain; Gene expression; JQ1; Microarrays; Primary human hepatocytes; RVX-208; Vascular inflammation