title: Polydopamine Coated Single-Walled Carbon Nanotubes as a Versatile Platform with Radionuclide Labeling for Multimodal Tumor Imaging and Therapy.
abstract: Single-walled carbon nanotubes (SWNTs) with various unique properties have attracted great attention in cancer theranostics. Herein, SWNTs are coated with a shell of polydopamine (PDA), which is further modified by polyethylene glycol (PEG). The PDA shell in the obtained SWNT@PDA-PEG could chelate Mn(2+), which together with metallic nanoparticulate impurities anchored on SWNTs offer enhanced both T1 and T2 contrasts under magnetic resonance (MR) imaging. Meanwhile, also utilizing the PDA shell, radionuclide (131)I could be easily labeled onto SWNT@PDA-PEG, enabling nuclear imaging and radioisotope cancer therapy. As revealed by MR & gamma imaging, efficient tumor accumulation of SWNT@PDA-(131)I-PEG is observed after systemic administration into mice. By further utilizing the strong near-infarared (NIR) absorbance of SWNTs, NIR-triggered photothermal therapy in combination with (131)I-based radioisotope therapy is realized in our animal experiments, in which a remarkable synergistic antitumor therapeutic effect is observed compared to monotherapies. Our work not only presents a new type of theranostic nanoplatform based on SWNTs, but also suggests the promise of PDA coating as a general approach to modify nano-agents and endow them with highly integrated functionalities.
authors: 1. Department of Pediatric Research, Children's Hospital affiliated to Soochow University, Suzhou, Jiangsu 215123, China.
authors: He
authors: H
authors: Zhao
authors: 2. Institute of Functional Nano & Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices, Soochow University, Suzhou, Jiangsu 215123, China.
authors: Yu
authors: Y
authors: Chao
authors: 2. Institute of Functional Nano & Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices, Soochow University, Suzhou, Jiangsu 215123, China.
authors: Jingjing
authors: J
authors: Liu
authors: 1. Department of Pediatric Research, Children's Hospital affiliated to Soochow University, Suzhou, Jiangsu 215123, China.
authors: Jie
authors: J
authors: Huang
authors: 1. Department of Pediatric Research, Children's Hospital affiliated to Soochow University, Suzhou, Jiangsu 215123, China.
authors: Jian
authors: J
authors: Pan
authors: 1. Department of Pediatric Research, Children's Hospital affiliated to Soochow University, Suzhou, Jiangsu 215123, China.
authors: Wanliang
authors: W
authors: Guo
authors: 1. Department of Pediatric Research, Children's Hospital affiliated to Soochow University, Suzhou, Jiangsu 215123, China.
authors: Jizhi
authors: J
authors: Wu
authors: 1. Department of Pediatric Research, Children's Hospital affiliated to Soochow University, Suzhou, Jiangsu 215123, China.
authors: Mao
authors: M
authors: Sheng
authors: 3. School of Radiation Medicine and Protection & School for Radiological and Interdisciplinary Sciences (RAD-X), Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, Medical College of Soochow University, Suzhou, Jiangsu 215123, China.
authors: Kai
authors: K
authors: Yang
authors: 1. Department of Pediatric Research, Children's Hospital affiliated to Soochow University, Suzhou, Jiangsu 215123, China.
authors: Jian
authors: J
authors: Wang
authors: 2. Institute of Functional Nano & Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices, Soochow University, Suzhou, Jiangsu 215123, China.
authors: Zhuang
authors: Z
authors: Liu
mesh_terms: D000818:Animals; D001672:Biocompatible Materials; D045744:Cell Line, Tumor; D003131:Combined Modality Therapy; D005260:Female; D007211:Indoles; D007457:Iodine Radioisotopes / Q000627:therapeutic use*; D008279:Magnetic Resonance Imaging / Q000379:methods; D051379:Mice; D008807:Mice, Inbred BALB C; D064847:Multimodal Imaging / Q000379:methods*; D037742:Nanotubes, Carbon; D009369:Neoplasms / Q000000981:diagnostic imaging* / Q000532:radiotherapy*; D010789:Phototherapy; D011092:Polyethylene Glycols; D011108:Polymers; D000068936:Theranostic Nanomedicine / Q000379:methods
chemical_list: D001672:Biocompatible Materials; D007211:Indoles; D007457:Iodine Radioisotopes; D037742:Nanotubes, Carbon; D011108:Polymers; C568283:polydopamine; D011092:Polyethylene Glycols
keywords: Combined therapy; Multimodal imaging; Polydopamine; Radiolabeling; Single-walled carbon nanotubes