title: A Genomics-Based Model for Prediction of Severe Bioprosthetic Mitral Valve Calcification.
abstract: Severe bioprosthetic mitral valve calcification is a significant problem in cardiovascular surgery. Unfortunately, clinical markers did not demonstrate efficacy in prediction of severe bioprosthetic mitral valve calcification. Here, we examined whether a genomics-based approach is efficient in predicting the risk of severe bioprosthetic mitral valve calcification. A total of 124 consecutive Russian patients who underwent mitral valve replacement surgery were recruited. We investigated the associations of the inherited variation in innate immunity, lipid metabolism and calcium metabolism genes with severe bioprosthetic mitral valve calcification. Genotyping was conducted utilizing the TaqMan assay. Eight gene polymorphisms were significantly associated with severe bioprosthetic mitral valve calcification and were therefore included into stepwise logistic regression which identified male gender, the T/T genotype of the rs3775073 polymorphism within the TLR6 gene, the C/T genotype of the rs2229238 polymorphism within the IL6R gene, and the A/A genotype of the rs10455872 polymorphism within the LPA gene as independent predictors of severe bioprosthetic mitral valve calcification. The developed genomics-based model had fair predictive value with area under the receiver operating characteristic (ROC) curve of 0.73. In conclusion, our genomics-based approach is efficient for the prediction of severe bioprosthetic mitral valve calcification.
authors: Research Institute for Complex Issues of Cardiovascular Diseases, Sosnovy Boulvevard 6, Kemerovo 650002, Russia. ponaav@kemcardio.ru.
authors: Anastasia V
authors: AV
authors: Ponasenko
authors: Research Institute for Complex Issues of Cardiovascular Diseases, Sosnovy Boulvevard 6, Kemerovo 650002, Russia. masha_hut@mail.ru.
authors: Maria V
authors: MV
authors: Khutornaya
authors: Research Institute for Complex Issues of Cardiovascular Diseases, Sosnovy Boulvevard 6, Kemerovo 650002, Russia. antonkutikhin@gmail.com.
authors: Anton G
authors: AG
authors: Kutikhin
authors: Research Institute for Complex Issues of Cardiovascular Diseases, Sosnovy Boulvevard 6, Kemerovo 650002, Russia. rutknv@kemcardio.ru.
authors: Natalia V
authors: NV
authors: Rutkovskaya
authors: Research Institute for Complex Issues of Cardiovascular Diseases, Sosnovy Boulvevard 6, Kemerovo 650002, Russia. annacepokina@mail.ru.
authors: Anna V
authors: AV
authors: Tsepokina
authors: Research Institute for Complex Issues of Cardiovascular Diseases, Sosnovy Boulvevard 6, Kemerovo 650002, Russia. kondnv@kemcardio.ru.
authors: Natalia V
authors: NV
authors: Kondyukova
authors: Research Institute for Complex Issues of Cardiovascular Diseases, Sosnovy Boulvevard 6, Kemerovo 650002, Russia. arseniy.yuzhalin@oncology.ox.ac.uk.|Department of Oncology, Cancer Research UK and Medical Research Council Oxford Institute for Radiation Oncology, University of Oxford, Old Road Campus Research Building, Roosevelt Drive, Oxford OX3 7DQ, UK. arseniy.yuzhalin@oncology.ox.ac.uk.
authors: Arseniy E
authors: AE
authors: Yuzhalin
authors: Research Institute for Complex Issues of Cardiovascular Diseases, Sosnovy Boulvevard 6, Kemerovo 650002, Russia. reception@kemcardio.ru.
authors: Leonid S
authors: LS
authors: Barbarash
mesh_terms: D001705:Bioprosthesis / Q000592:standards*; D002114:Calcinosis / Q000235:genetics*; D006350:Heart Valve Prosthesis / Q000592:standards*; D006801:Humans; D008297:Male; D008875:Middle Aged; D008943:Mitral Valve / Q000601:surgery; D011110:Polymorphism, Genetic; D019947:Receptors, Interleukin-6 / Q000235:genetics; D051216:Toll-Like Receptor 6 / Q000235:genetics
chemical_list: C508603:IL6R protein, human; D019947:Receptors, Interleukin-6; C495368:TLR6 protein, human; D051216:Toll-Like Receptor 6
keywords: bioprosthetic heart valve; calcification; genetic association; interleukin-6; predictive model