title: Association between chronic hepatitis C and hepatitis C/HIV co-infection and the development of colorectal adenomas.
abstract: BACKGROUND
  Limited knowledge exists about the effects chronic hepatitis C virus (HCV) infection has in the development of colorectal adenomas (CRA). Data regarding the association between chronic HIV infection and the development of CRA is scarce as well. We aim to determine if there is an association between the development of CRA and chronic infection with HCV and HCV/HIV co-infection.
  
  
  METHODS
  From July 1, 2009 to March 31, 2011 a total of 2,051 patients that underwent colonoscopy were included in our study. The population was divided into 2 study groups: those patients who tested positive for HCV, and HCV/HIC; the control groups consisted of patients whose results were negative. Fisher's exact χ(2) test for categorical variables and t-test for continuous variables was used to analyze data between groups. Logistic regression was performed to obtain odds ratios (OR).
  
  
  RESULTS
  CRA detection was higher in the HCV than in the control group (26.3% vs. 20.2%; P=1.02); Likewise, the incidence of CRA (25.5% vs. 20.8%; P=0.63) was higher in the co-infection group. However, in both of the study groups this difference was non-statistical.
  
  
  CONCLUSIONS
  A higher detection rate of CRP was seen in the HCV population; however, it failed to reach statistical significance. Whether co-infection with HIV/HCV increases the incidence of CRA and/or has a synergistic effect remains to be determined. The small sample population and the retrospective single institution nature of our study, as well as other confounders may have contributed to our negative results. However, our findings question whether HCV and HIV/HCV co-infected patients will benefit from screening colonoscopy at an earlier age. This issue merits further investigation with a large multi-center prospective study.
authors: Department of Medicine, Division of Hematology-Oncology, Sylvester Comprehensive Cancer Center, Miller School of Medicine, FL, USA ;
authors: Jorge
authors: J
authors: Hurtado-Cordovi
authors: Department of Internal Medicine, Division of Digestive Diseases and Nutrition, University of South Florida Morsani College of Medicine, Tampa, FL, USA ;
authors: Ashley H
authors: AH
authors: Davis-Yadley
authors: Department of Gastroenterology, Division of Digestive Diseases and Nutrition, University of South Florida Morsani College of Medicine, Tampa, FL, USA ;
authors: Seth
authors: S
authors: Lipka
authors: Department of Internal Medicine, Division of Gastroenterology, Nassau University Medical Center Associated with North Shore-Long Island Jewish Health Care System, East Meadow, NY, USA ;
authors: Magdalene
authors: M
authors: Vardaros
authors: Department of Medicine, Division of Gastroenterology, Hepatology University of Iowa Hospitals and Clinics, Iowa City, IA, USA.
authors: Huafeng
authors: H
authors: Shen
keywords: HIV; co-infection; colonoscopy; colorectal cancer (CRC); hepatitis C; screening colonoscopy