title: Relationship between premature ejaculation and depression: A PRISMA-compliant systematic review and meta-analysis.
abstract: BACKGROUND
  Premature ejaculation (PE) is the most prevalent male sexual dysfunction. Epidemiologic findings are inconsistent concerning the risk for depression associated with PE.
  
  
  OBJECTIVE
  The aim of this study was to investigate the potential association between between depression and risk of PE.
  
  
  METHODS
  We conducted a literature search of PubMed, Embase, and the Cochrane Library from these databases' inception through June 2014 for observational epidemiological studies examining the association between depression on risk of PE.
  
  
  METHODS
  Studies were selected if they reported the risk estimates for PE associated with depression.
  
  
  METHODS
  patients>18 years of age suffering from PE.
  
  
  METHODS
  a history of depressive disorder.
  
  
  METHODS
  These odds ratios (ORs) were pooled using a random or fixed effects model and were tested for heterogeneity. Subgroup analysis was employed to explore heterogeneity.
  
  
  RESULTS
  Eight trials involving 18,035 patients were included in the meta-analysis. Depression were statistically significantly associated with the risk of PE (OR = 1.63, 95% CI:1.42-1.87). There was no evidence of between-study heterogeneity (P = 0.623, I = 0.0%). The association was similar when stratified by mean age, geographical area, study design, sample size, publication year, and controlling key confounders.
  
  
  CONCLUSIONS
  The severity of depression and PE could not be identified due to unavailable data of trials. No evidence of publication bias was observed.
  
  
  CONCLUSIONS
  These findings provide evidence that depression is associated with a significantly increased risk of PE. In addition, more prospective studies are necessary to evaluate the association and identify the ideal treatment.
  CRD42016041272.
authors: Department of Urology, Renmin Hospital of Wuhan University, Wuhan, Hubei Department of Breast and Thyroid Surgery, Renmin Hospital of Wuhan University, Wuhan, Hubei Department of Urology, Longjiang Hospital of Shunde District in Foshan City Department of Physiology of Southern Medical University, Guangzhou, Guangdong Department of Infertility and Sexual Medicine, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou Department of Urology & Andrology, Minimally Invasive Surgery Center, Guangdong Key Laboratory of Urology, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China.
authors: Yue
authors: Y
authors: Xia
authors: Juanjuan
authors: J
authors: Li
authors: Guang
authors: G
authors: Shan
authors: Huijun
authors: H
authors: Qian
authors: Tao
authors: T
authors: Wang
authors: Wei
authors: W
authors: Wu
authors: Jun
authors: J
authors: Chen
authors: Luhao
authors: L
authors: Liu
mesh_terms: D003863:Depression / Q000150:complications*; D006801:Humans; D008297:Male; D061686:Premature Ejaculation / Q000150:complications / Q000523:psychology*; D012307:Risk Factors