title: The epigenome: the next substrate for engineering.
abstract: We are entering an era of epigenome engineering. The precision manipulation of chromatin and epigenetic modifications provides new ways to interrogate their influence on genome and cell function and to harness these changes for applications. We review the design and state of epigenome editing tools, highlighting the unique regulatory properties afforded by these systems.
authors: Department of Biomedical Engineering and Biological Design Center, Boston University, Boston, MA, 02215, USA.
authors: Minhee
authors: M
authors: Park
authors: Department of Chemical and Biomolecular Engineering, North Carolina State University, Raleigh, NC, 27695, USA.
authors: Albert J
authors: AJ
authors: Keung
authors: Department of Biomedical Engineering and Biological Design Center, Boston University, Boston, MA, 02215, USA. akhalil@bu.edu.|Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, 02115, USA. akhalil@bu.edu.
authors: Ahmad S
authors: AS
authors: Khalil
mesh_terms: D002843:Chromatin / Q000235:genetics*; D044127:Epigenesis, Genetic; D057890:Epigenomics; D015894:Genome, Human; D006801:Humans
chemical_list: D002843:Chromatin