title: Network pharmacology dissection of multiscale mechanisms of herbal medicines in stage IV gastric adenocarcinoma treatment.
abstract: Increasing evidence has shown that Chinese Herbal Medicine (CHM) has efficient therapeutic effects for advanced gastric adenocarcinoma, while the therapeutic mechanisms underlying this treatment remain unclear.In this study, the Kaplan-Meier method and Cox regression analysis were used to evaluate the survival benefit of CHM treatment, and correlation analysis was applied to identify the most effective components in the formulas. A network pharmacological approach was developed to decipher the potential therapeutic mechanisms of CHM.CHM treatment was an independent protective factor. The hazard ratio was 0.364 (95% CI 0.245-0.540; P < 0.001). The median survival time was 18 months for patients who received CHM treatment, while for patients without CHM treatment was decreased to 9 months (P < 0.001). Thirteen out of the total 204 herbs were significantly correlated with favorable survival outcomes (P < 0.05), likely representing the most effective components in these formulas. Bioinformatics analyses suggested that the simultaneous manipulation of multiple targets in proliferation pathways (such as epidermal growth factor receptor, fibroblast growth factor receptor 2, human epidermal growth factor receptor 2, proliferating cell nuclear antigen, and insulin like growth factor 2) and the process of cancer metastasis (collagen families, fibronectin 1 and matrix metalloproteinases families) might largely account for the mechanisms of the 13 herbs against gastric adenocarcinoma.A network pharmacology method was introduced to decipher the underlying mechanisms of CHM, which provides a good foundation for herbal research based on clinical data.
authors: Modern Research Center for Traditional Chinese Medicine, Shanxi University, Taiyuan Key Laboratory of Cancer Prevention and Therapy, National Clinical Research Center for Cancer, Tianjin Medical University Cancer Institute and Hospital, Tianjin College of Chemistry and Chemical Engineering, Shanxi University, Taiyuan, P.R. China.
authors: Li
authors: L
authors: Gao
authors: Jian
authors: J
authors: Hao
authors: Yang-Yang
authors: YY
authors: Niu
authors: Miao
authors: M
authors: Tian
authors: Xue
authors: X
authors: Yang
authors: Cui-Hong
authors: CH
authors: Zhu
authors: Xiu-Li
authors: XL
authors: Ding
authors: Xiao-Hui
authors: XH
authors: Liu
authors: Hao-Ran
authors: HR
authors: Zhang
authors: Chang
authors: C
authors: Liu
authors: Xue-Mei
authors: XM
authors: Qin
authors: Xiong-Zhi
authors: XZ
authors: Wu
mesh_terms: D000230:Adenocarcinoma / Q000188:drug therapy* / Q000235:genetics / Q000401:mortality / Q000473:pathology; D063646:Carcinogenesis / Q000235:genetics; D049109:Cell Proliferation / Q000187:drug effects / Q000235:genetics; D019295:Computational Biology; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D005260:Female; D015870:Gene Expression / Q000187:drug effects; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D016016:Proportional Hazards Models; D012189:Retrospective Studies; D015398:Signal Transduction / Q000187:drug effects / Q000235:genetics; D013274:Stomach Neoplasms / Q000188:drug therapy* / Q000235:genetics / Q000401:mortality / Q000473:pathology; D015996:Survival Rate
chemical_list: D004365:Drugs, Chinese Herbal