title: Cord and blood levels of newborn IgE: Correlation, role and influence of maternal IgE.
abstract: The role of cord blood immunoglobulin E (IgE) levels in predicting the development of atopy has been widely investigated. The aim of the study was to evaluate the correlation between serum and cord blood total IgE in newborns and the possible influence of the atopic status of the mother on them. It was also investigated the possible role of gestational age on neonatal total IgE levels. We considered 763 deliveries, 724≥37 weeks of gestation and 39<37 weeks of gestation. 14% of mothers (13.7% at term, 15.4% preterm) showed high total IgE levels. The results showed a significant correlation between serum and cord IgE levels both in preterm and term newborns. The data revealed also that mother's total IgE levels affect both neonatal serum and cord total IgE levels. For the latters we also found child gender as an additional independent predictor. On the contrary total IgE levels are not affected by gestational age. Clinical limitations of total IgE is known but their determination can be useful to define atopy and to suggest follow-up of the children.
authors: Department of Paediatrics, Foundation IRCCS Policlinico San Matteo, University of Pavia, Pavia, Italy. Electronic address: m.deamici@smatteo.pv.it.
authors: M
authors: M
authors: De Amici
authors: Department of Maternal and Children's Health, Obstetrics and Gynecology Unit, Foundation IRCCS Policlinico San Matteo, University of Pavia, Pavia, Italy.
authors: F
authors: F
authors: Perotti
authors: Department of Paediatrics, Foundation IRCCS Policlinico San Matteo, University of Pavia, Pavia, Italy.
authors: G L
authors: GL
authors: Marseglia
authors: Department of Maternal and Children's Health, Obstetrics and Gynecology Unit, Foundation IRCCS Policlinico San Matteo, University of Pavia, Pavia, Italy.
authors: A M
authors: AM
authors: Ierullo
authors: Department of Maternal and Children's Health, Neonatal Intensive Care Unit, Foundation IRCCS Policlinico San Matteo, University of Pavia, Pavia, Italy.
authors: L
authors: L
authors: Bollani
authors: Department of Maternal and Children's Health, Neonatal Intensive Care Unit, Foundation IRCCS Policlinico San Matteo, University of Pavia, Pavia, Italy.
authors: L
authors: L
authors: Decembrino
authors: Department of Paediatrics, Foundation IRCCS Policlinico San Matteo, University of Pavia, Pavia, Italy.
authors: A
authors: A
authors: Licari
authors: Department of Electrical, Computer and Biomedical Engineering, University of Pavia, Italy.
authors: S
authors: S
authors: Quaglini
authors: Department of Maternal and Children's Health, Neonatal Intensive Care Unit, Foundation IRCCS Policlinico San Matteo, University of Pavia, Pavia, Italy.
authors: M
authors: M
authors: Stronati
authors: Department of Maternal and Children's Health, Obstetrics and Gynecology Unit, Foundation IRCCS Policlinico San Matteo, University of Pavia, Pavia, Italy.
authors: A
authors: A
authors: Spinillo
mesh_terms: D005260:Female; D005312:Fetal Blood / Q000276:immunology*; D005865:Gestational Age; D006801:Humans; D007112:Immunity, Maternally-Acquired; D007073:Immunoglobulin E / Q000097:blood* / Q000276:immunology*; D007231:Infant, Newborn; D008297:Male; D009035:Mothers; D016017:Odds Ratio; D011247:Pregnancy
chemical_list: D007073:Immunoglobulin E
keywords: Gestational age; Pregnance; Total IgE