title: Cytokines as a predictor of clinical response following hip arthroscopy: minimum 2-year follow-up.
abstract: Hip arthroscopy in patients with osteoarthritis has been shown to have suboptimal outcomes. Elevated cytokine concentrations in hip synovial fluid have previously been shown to be associated with cartilage pathology. The purpose of this study was to determine whether a relationship exists between hip synovial fluid cytokine concentration and clinical outcomes at a minimum of 2 years following hip arthroscopy. Seventeen patients without radiographic evidence of osteoarthritis had synovial fluid aspirated at time of portal establishment during hip arthroscopy. Analytes included fibronectin-aggrecan complex as well as a multiplex cytokine array. Patients completed the modified Harris Hip Score, Western Ontario and McMaster Universities Arthritis Index and the International Hip Outcomes Tool pre-operatively and at a minimum of 2 years following surgery. Pre and post-operative scores were compared with a paired t-test, and the association between cytokine values and clinical outcome scores was performed with Pearson's correlation coefficient with an alpha value of 0.05 set as significant. Sixteen of seventeen patients completed 2-year follow-up questionnaires (94%). There was a significant increase in pre-operative to post-operative score for each clinical outcome measure. No statistically significant correlation was seen between any of the intra-operative cytokine values and either the 2-year follow-up scores or the change from pre-operative to final follow-up outcome values. No statistically significant associations were seen between hip synovial fluid cytokine concentrations and 2-year follow-up clinical outcome assessment scores for those undergoing hip arthroscopy.
authors: Department of Orthopaedic Surgery, Stanford University, 450 Broadway St, Mail Code 6342, Redwood City, CA 94063, USA.
authors: Lauren M
authors: LM
authors: Shapiro
authors: Department of Orthopaedic Surgery, Stanford University, 450 Broadway St, Mail Code 6342, Redwood City, CA 94063, USA.
authors: Marc R
authors: MR
authors: Safran
authors: Department of Orthopaedic Surgery, Stanford University, 450 Broadway St, Mail Code 6342, Redwood City, CA 94063, USA.
authors: William J
authors: WJ
authors: Maloney
authors: Department of Orthopaedic Surgery, Stanford University, 450 Broadway St, Mail Code 6342, Redwood City, CA 94063, USA.
authors: Stuart B
authors: SB
authors: Goodman
authors: Department of Orthopaedic Surgery, Stanford University, 450 Broadway St, Mail Code 6342, Redwood City, CA 94063, USA.
authors: James I
authors: JI
authors: Huddleston
authors: Department of Orthopaedic Surgery, Stanford University, 450 Broadway St, Mail Code 6342, Redwood City, CA 94063, USA.
authors: Michael J
authors: MJ
authors: Bellino
authors: Cytonics Corporation, 210 Jupiter Lakes Blvd 3102, Jupiter, FL 33458, USA.
authors: Gaetano J
authors: GJ
authors: Scuderi
authors: Department of Orthopaedic Surgery, Stanford University, 450 Broadway St, Mail Code 6342, Redwood City, CA 94063, USA; Veterns Administration, Department of Orthopaedic Surgery, 3801 Miranda Ave, Mail Code Ortho 112, Palo Alto, CA 94304, USA.
authors: Geoffrey D
authors: GD
authors: Abrams