title: CREBRF variant increases obesity risk and protects against diabetes in Samoans.
abstract: A genome-wide study in Samoans has identified a protein-altering variant (p.Arg475Gln) in CREBRF as being associated with 1.3-fold increased risk of obesity and, intriguingly, 1.6-fold decreased risk of type 2 diabetes. This variant, which is common among Samoans (minor allele frequency = 26%) but extremely rare in other populations, promotes fat storage and reduces energy use in cellular models.
authors: Charles Bronfman Institute for Personalized Medicine, Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
authors: Ruth J F
authors: RJ
authors: Loos
mesh_terms: D003924:Diabetes Mellitus, Type 2; D055106:Genome-Wide Association Study; D006801:Humans; D009765:Obesity; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors