title: The independent association of mean platelet volume with overall survival in multiple myeloma.
abstract: We retrospectively analyzed the association between mean platelet volume (MPV) and prognosis in 62 newly diagnosed multiple myeloma (MM) patients. The associations between MPV and clinical characteristics were assessed. The log-rank test and the Cox proportional hazards model were used to evaluate the effect of MPV on survival. A MPV value of 8.50 fl was considered to be the optimal cut-off value for prognosis. MPV was associated with IgA isotype (P=0.012), serum creatinine concentration > 176.8 μmol/L (P=0.025) and IgH rearrangement (P=0.008). The log-rank test demonstrated that patients with low MPV experienced a shorter overall survival (OS) (P=0.0397). The multivariate analysis demonstrated that low MPV was an independent prognostic factor for OS [hazard ratio (HR)=2.44, P=0.026]. Therefore, we demonstrated that low MPV predicted an unfavorable prognosis in patients with MM.
authors: Department of Hematology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, PR China.
authors: Qiang
authors: Q
authors: Zhuang
authors: Department of Emergency Medicine, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, PR China.
authors: Lina
authors: L
authors: Xiang
authors: Department of Pneumology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, PR China.
authors: Hanyan
authors: H
authors: Xu
authors: Department of Hematology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, PR China.
authors: Fang
authors: F
authors: Fang
authors: Department of Hematology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, PR China.
authors: Chongyun
authors: C
authors: Xing
authors: Department of Hematology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, PR China.
authors: Bin
authors: B
authors: Liang
authors: Department of Hematology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, PR China.
authors: Kang
authors: K
authors: Yu
authors: Department of Hematology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, PR China.|Department of Pediatric Hematology-Oncology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, PR China.
authors: Jianhua
authors: J
authors: Feng
mesh_terms: D000328:Adult; D000368:Aged; D015331:Cohort Studies; D003404:Creatinine / Q000097:blood; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007070:Immunoglobulin A / Q000097:blood; D007074:Immunoglobulin G / Q000097:blood; D053208:Kaplan-Meier Estimate; D008297:Male; D063847:Mean Platelet Volume; D008875:Middle Aged; D009101:Multiple Myeloma / Q000097:blood* / Q000401:mortality*; D015999:Multivariate Analysis; D011379:Prognosis; D016016:Proportional Hazards Models; D012372:ROC Curve; D012189:Retrospective Studies; D013927:Thrombosis / Q000097:blood / Q000150:complications; D016896:Treatment Outcome
chemical_list: D007070:Immunoglobulin A; D007074:Immunoglobulin G; D003404:Creatinine
keywords: mean platelet volume; multiple myeloma; prognosis; survival