title: AA-negative and Kappa-positive Amyloidosis in a Patient with Rheumatoid Arthritis.
abstract: A 57-year-old Japanese woman with a 5-year history of rheumatoid arthritis (RA) was admitted to our hospital for an evaluation of nephrotic range proteinuria (4.8 g/day). A renal biopsy led to the diagnosis of amyloidosis according to strong positivity for Congo red staining and the detection of microfibrillar structures on electron microscopy that were negative for AA and positive for kappa light chain. Combination therapy with high-dose melphalan and autologous stem cell transplantation was performed according to the regimen for AL amyloidosis. Her proteinuria and RA subsided, but relapsed after 3 years. This is the first report regarding kappa light chain amyloidosis in an RA patient.
authors: Nephrology Center, Toranomon Hospital Kajigaya, Japan.
authors: Toshiharu
authors: T
authors: Ueno
authors: Keiichi
authors: K
authors: Sumida
authors: Junichi
authors: J
authors: Hoshino
authors: Tatsuya
authors: T
authors: Suwabe
authors: Koki
authors: K
authors: Mise
authors: Ryo
authors: R
authors: Hazue
authors: Noriko
authors: N
authors: Hayami
authors: Rikako
authors: R
authors: Hiramatsu
authors: Masahiro
authors: M
authors: Kawada
authors: Aya
authors: A
authors: Imafuku
authors: Eiko
authors: E
authors: Hasegawa
authors: Naoki
authors: N
authors: Sawa
authors: Kenmei
authors: K
authors: Takaichi
authors: Keiichi
authors: K
authors: Kinowaki
authors: Kenichi
authors: K
authors: Ohashi
authors: Takeshi
authors: T
authors: Fujii
authors: Aya
authors: A
authors: Nishida
authors: Yoshifumi
authors: Y
authors: Ubara
mesh_terms: D000686:Amyloidosis / Q000150:complications* / Q000473:pathology; D018906:Antineoplastic Agents, Alkylating / Q000627:therapeutic use; D001172:Arthritis, Rheumatoid / Q000150:complications*; D003131:Combined Modality Therapy; D005260:Female; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D008558:Melphalan / Q000627:therapeutic use; D008875:Middle Aged; D011507:Proteinuria
chemical_list: D018906:Antineoplastic Agents, Alkylating; D008558:Melphalan