title: Therapeutic effect of apple pectin in obese rats.
abstract: Obesity is the most common nutritional disorder and is associated with significant comorbidities such as dyslipidemia, atherosclerosis and type 2 diabetes. This pathology is changing worldwide and is a risk factor for cardiovascular disease. This study, carried out on adult male Wistar rats, evaluates the inhibitory effects of supplementation with apple pectin molecule on obesity. Under our experimental conditions, administration of pectin molecule decreased 1) the total cholesterol (TC), LDL-cholesterol (LDL-ch) and triglycerides (TG) levels as well as ASAT, ALAT, LDH, ALP, UREA and uric acid (UC) levels in blood serum; and 2) increased the creatinine levels (CREA), compared to HFD group. TBARS concentrations decreased in liver, kidney, and serum by 20%, 29% and 19%, respectively, in a group treated with high-fat diet and pectin (HFD+Pec) compared to a HFD-treated group. The same treatment with pectin molecule increased superoxide dismutase, glutathion peroxidase and catalase activities by 39%, 14% and 16% in liver; 5%, 7% and 31% in kidney; and 9%, 32% and 22% in blood serum in the HFD Pec-treated group. The anti-obesity effects of the pectin molecule in several organs are mainly due to the interaction of this molecule with both the polysaccharide and the enzyme system which can be determined by phytochemical analysis.
authors: Laboratory of Environmental Physiopathology, Valorization of Bioactive Molecules and Mathematical Modeling, Faculty of Sciences of Sfax, Road Soukra km 3.5, PB no 1171-3000, Sfax, Tunisia; Laboratory Animal Eco Physiology, Faculty of Sciences, Sidi Ahmed Zarrouk, 2112, Gafsa, Tunisia. Electronic address: samout_noura@hotmail.fr.
authors: Noura
authors: N
authors: Samout
authors: Laboratory of Environmental Physiopathology, Valorization of Bioactive Molecules and Mathematical Modeling, Faculty of Sciences of Sfax, Road Soukra km 3.5, PB no 1171-3000, Sfax, Tunisia; Laboratory Animal Eco Physiology, Faculty of Sciences, Sidi Ahmed Zarrouk, 2112, Gafsa, Tunisia.
authors: Hafsia
authors: H
authors: Bouzenna
authors: Laboratory of Environmental Physiopathology, Valorization of Bioactive Molecules and Mathematical Modeling, Faculty of Sciences of Sfax, Road Soukra km 3.5, PB no 1171-3000, Sfax, Tunisia; Laboratory Animal Eco Physiology, Faculty of Sciences, Sidi Ahmed Zarrouk, 2112, Gafsa, Tunisia.
authors: Sabah
authors: S
authors: Dhibi
authors: Unity of Commun Services, Faculty of sciences, Sidi Ahmed Zarrouk, 2112, Gafsa, Tunisia.
authors: Sana
authors: S
authors: Ncib
authors: Laboratory of Environmental Physiopathology, Valorization of Bioactive Molecules and Mathematical Modeling, Faculty of Sciences of Sfax, Road Soukra km 3.5, PB no 1171-3000, Sfax, Tunisia.
authors: Abdelfattah
authors: A
authors: ElFeki
authors: Laboratory of Environmental Physiopathology, Valorization of Bioactive Molecules and Mathematical Modeling, Faculty of Sciences of Sfax, Road Soukra km 3.5, PB no 1171-3000, Sfax, Tunisia; Laboratory Animal Eco Physiology, Faculty of Sciences, Sidi Ahmed Zarrouk, 2112, Gafsa, Tunisia.
authors: Najla
authors: N
authors: Hfaiedh
mesh_terms: D000818:Animals; D019440:Anti-Obesity Agents / Q000302:isolation & purification / Q000627:therapeutic use*; D059305:Diet, High-Fat / Q000009:adverse effects*; D004305:Dose-Response Relationship, Drug; D008297:Male; D027845:Malus; D009765:Obesity / Q000188:drug therapy* / Q000209:etiology / Q000378:metabolism; D010368:Pectins / Q000302:isolation & purification / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar; D016896:Treatment Outcome
chemical_list: D019440:Anti-Obesity Agents; D010368:Pectins
keywords: Antioxidant enzymes; DPPH; FTIR; Lipid peroxidation (TBARS); Obese rats; Pectin molecule