title: Hippocampal changes in STZ-model of Alzheimer's disease are dependent on sex.
abstract: The majority of Alzheimer's disease (AD) cases are sporadic and aging is the major risk factor for developing the disease, affecting more women than men. In spite of different gender prevalence, most experimental studies in animal models have been performed in male. This study investigates the streptozotocin (STZ)-induced AD model at three different times (2, 4 and 8 weeks afterwards) and in male and female rats, evaluating cognitive deficit, cholinergic neurotransmission, glucose uptake, glutathione content and specific glial markers (GFAP and S100B protein) in the hippocampus of the rat. Our data reinforce the relevance of alterations in STZ model of dementia, reported in the genesis and/or progression of AD such as cholinergic deficit and glucose uptake decrease. All alterations in these parameters (except GFAP) were dependent on sex. It is unclear, at this moment, which alterations are due to sex steroid modulation. In spite of limitations of this experimental model, these data may contribute to understand AD susceptibility and progression dependent on sex.
authors: Departamento de Bioquímica, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Ramiro Barcelos, 2600-anexo, 90035-003, Porto Alegre, RS, Brazil.
authors: Regina
authors: R
authors: Biasibetti
authors: Departamento de Bioquímica, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Ramiro Barcelos, 2600-anexo, 90035-003, Porto Alegre, RS, Brazil.
authors: João Paulo
authors: JP
authors: Almeida Dos Santos
authors: Departamento de Bioquímica, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Ramiro Barcelos, 2600-anexo, 90035-003, Porto Alegre, RS, Brazil.
authors: Letícia
authors: L
authors: Rodrigues
authors: Departamento de Bioquímica, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Ramiro Barcelos, 2600-anexo, 90035-003, Porto Alegre, RS, Brazil.
authors: Krista Minéia
authors: KM
authors: Wartchow
authors: Departamento de Bioquímica, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Ramiro Barcelos, 2600-anexo, 90035-003, Porto Alegre, RS, Brazil.
authors: Lucas Zingano
authors: LZ
authors: Suardi
authors: Departamento de Bioquímica, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Ramiro Barcelos, 2600-anexo, 90035-003, Porto Alegre, RS, Brazil.
authors: Patrícia
authors: P
authors: Nardin
authors: Departamento de Bioquímica, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Ramiro Barcelos, 2600-anexo, 90035-003, Porto Alegre, RS, Brazil.
authors: Nicholas Guerini
authors: NG
authors: Selistre
authors: Departamento de Bioquímica, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Ramiro Barcelos, 2600-anexo, 90035-003, Porto Alegre, RS, Brazil.
authors: Dandara
authors: D
authors: Vázquez
authors: Departamento de Bioquímica, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Ramiro Barcelos, 2600-anexo, 90035-003, Porto Alegre, RS, Brazil. Electronic address: casg@ufrgs.br.
authors: Carlos-Alberto
authors: CA
authors: Gonçalves
mesh_terms: D000544:Alzheimer Disease / Q000139:chemically induced* / Q000473:pathology*; D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000633:toxicity; D002795:Choline O-Acetyltransferase / Q000378:metabolism; D004195:Disease Models, Animal; D005260:Female; D005904:Glial Fibrillary Acidic Protein / Q000378:metabolism; D005947:Glucose / Q000378:metabolism; D005978:Glutathione / Q000378:metabolism; D006624:Hippocampus / Q000187:drug effects / Q000473:pathology*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D021641:Recognition, Psychology / Q000187:drug effects; D064568:S100 Calcium Binding Protein beta Subunit / Q000378:metabolism; D012727:Sex Characteristics; D013311:Streptozocin / Q000633:toxicity; D013997:Time Factors
chemical_list: D000903:Antibiotics, Antineoplastic; D005904:Glial Fibrillary Acidic Protein; D064568:S100 Calcium Binding Protein beta Subunit; D013311:Streptozocin; D002795:Choline O-Acetyltransferase; D005978:Glutathione; D005947:Glucose
keywords: Alzheimer; Astrocyte; ChAT; Glucose uptake; Hippocampus; Sex