title: Iridium(III)-Catalyzed Regioselective C7-Amination of N-Pivaloylindoles with Sulfonoazides.
abstract: Direct C7-amination of N-pivaloylindoles has been achieved using a combination of [Cp*IrCl2]2, AgNTf2, and AgOAc as the catalyst and sulfonoazides as the nitrogen source. The reaction proceeded at room temperature to 80 °C to afford 7-sulfonamidoindoles in good to excellent yields. The reaction is broadly applicable to the C7-amination of a wide variety of 3-, 4-, 5-, and 6-substituted N-pivaloylindoles with either alkyl or aryl sulfonoazides.
authors: State Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences , 345 Lingling Lu, Shanghai 200032, China.
authors: Lanting
authors: L
authors: Xu
authors: Merck Research Laboratories, P.O. Box 2000, RY800-D280, Rahway, New Jersey 07065-0900, United States.
authors: Lushi
authors: L
authors: Tan
authors: State Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences , 345 Lingling Lu, Shanghai 200032, China.
authors: Dawei
authors: D
authors: Ma