title: Timing is everything? Reconciling the results of recent trials in acute kidney injury.
abstract: Observational studies have failed to establish the optimal timing of renal replacement therapy in critically ill adults with acute kidney injury, with some studies suggesting benefit and others suggesting the potential for harm with earlier initiation. Two recent randomized trials have addressed this controversy, also with conflicting results. Careful consideration of differences between the 2 studies is essential when applying the results to clinical practice in the intensive care unit.
authors: Department of Medicine, Division of Nephrology, Icahn School of Medicine at Mount Sinai, New York, New York, USA. Electronic address: christina.wyatt@mssm.edu.
authors: Christina M
authors: CM
authors: Wyatt
authors: Department of Medicine, Division of Nephrology, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
authors: Steven G
authors: SG
authors: Coca
mesh_terms: D058186:Acute Kidney Injury; D000328:Adult; D016638:Critical Illness; D006801:Humans; D007362:Intensive Care Units; D017582:Renal Replacement Therapy; D013997:Time Factors; D016896:Treatment Outcome