title: Methods for generating paired competing risks data.
abstract: OBJECTIVE
  Clustered competing risks data arise often in genetic studies, multicenter investigations, and matched-pairs studies. In the last two decades, major advances in competing risks theory had been made. Many new statistical methods need to be evaluated via simulation studies. Some mechanisms for simulating clustered competing risks data have been considered in the literature. However, most of them produce data where the strength of the dependence between individuals within a cluster is not clear. In this article, we aim to examine various techniques for generating bivariate competing risks data.
  
  
  METHODS
  Theoretical framework for simulating dependent competing risks data using latent failure time approach, multistate models, and shared frailty models is described. The steps needed to implement each method are outlined. Properties of each technique are discussed and standard measures of association are provided in order to assess the degree of dependence in simulated paired competing risks data.
  
  
  CONCLUSIONS
  In addition to describing a variety of techniques to generate dependent competing risks data, the cross-hazard ratios from multiple scenarios for each method are computed. The cross-hazard ratios provide a means to compare the level of dependence of the generated data across methods. This acts as a guide for researchers to select an approach and the parameters needed to achieve the desired degree of dependence for their simulation studies.
authors: Division of Biostatistics, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA. Electronic address: ruta@mcw.edu.
authors: Ruta
authors: R
authors: Brazauskas
authors: Department of Health Sciences Research, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA.
authors: Jennifer
authors: J
authors: Le-Rademacher
mesh_terms: D000465:Algorithms; D003198:Computer Simulation; D006801:Humans; D012307:Risk Factors
keywords: Competing risks; Cross-hazard ratio; Paired data; Simulation study