title: Novel Hydrogel Material as a Potential Embolic Agent in Embolization Treatments.
abstract: We report a novel graphene-oxide (GO) enhanced polymer hydrogel (GPH) as a promising embolic agent capable of treating cerebrovascular diseases and malignant tumors, using the trans-catheter arterial embolization (TAE) technique. Simply composed of GO and generation five poly(amidoamine) dendrimers (PAMAM-5), our rheology experiments reveal that GPH exhibits satisfactory mechanical strength, which resist the high pressures of blood flow. Subcutaneous experiments on Sprague-Dawley (SD) rats demonstrate the qualified biocompatibility of GPH. Finally, our in vivo experiments on New Zealand rabbits, which mix GPH with the X-ray absorbing contrast agent, Iohexol, reveal complete embolization of the artery. We also note that GPH shortens embolization time and exhibits low toxicity in follow-up experiments. Altogether, our study demonstrates that GPH has many advantages over the currently used embolic agents and has potential applications in clinical practice.
authors: Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai 200040, China.
authors: Feng
authors: F
authors: Zhou
authors: Department of Chemistry and Collaborative Innovation Center of Chemistry for Energy Materials, Fudan University, Shanghai 200433, China.
authors: Liming
authors: L
authors: Chen
authors: Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai 200040, China.
authors: Qingzhu
authors: Q
authors: An
authors: Department of Chemistry and Collaborative Innovation Center of Chemistry for Energy Materials, Fudan University, Shanghai 200433, China.
authors: Liang
authors: L
authors: Chen
authors: Department of Chemistry and Collaborative Innovation Center of Chemistry for Energy Materials, Fudan University, Shanghai 200433, China.
authors: Ying
authors: Y
authors: Wen
authors: Department of Chemistry and Collaborative Innovation Center of Chemistry for Energy Materials, Fudan University, Shanghai 200433, China.
authors: Fang
authors: F
authors: Fang
authors: Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai 200040, China.
authors: Wei
authors: W
authors: Zhu
authors: Department of Chemistry and Collaborative Innovation Center of Chemistry for Energy Materials, Fudan University, Shanghai 200433, China.
authors: Tao
authors: T
authors: Yi
mesh_terms: D000818:Animals; D050091:Dendrimers / Q000737:chemistry / Q000494:pharmacology; D004621:Embolization, Therapeutic / Q000379:methods*; D005260:Female; D006108:Graphite / Q000737:chemistry / Q000494:pharmacology; D020100:Hydrogels / Q000737:chemistry / Q000494:pharmacology; D007472:Iohexol / Q000737:chemistry / Q000494:pharmacology; D011817:Rabbits; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D050091:Dendrimers; D020100:Hydrogels; C104700:PAMAM Starburst; D007472:Iohexol; D006108:Graphite