title: Spirobisnaphthalenes and lactones from the seeds of Strychnos angustiflora with potential anti-inflammatory activity.
abstract: Three new spirobisnaphthalenes (1-3), a new, natural spirobisnaphthalene product (4), and two new 12-membered ring lactones (11-12), with six known compounds (5-10), were isolated from the seeds of Strychnos angustiflora. Their structures were elucidated by extensive spectroscopic analysis. The absolute configurations of 1-4 were assigned by computational methods. Compounds 1, 5 and 9 inhibited lipopolysaccharide-induced NO production in BV2 cells with IC50 values of 4.85, 2.05, and 1.16μM, respectively (positive control curcumin, IC50=1.42μM). This is the first report on the anti-inflammatory activities of spirobisnaphthalenes.
authors: State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China.
authors: Hua
authors: H
authors: Jiang
authors: State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China.
authors: Shuang-Gang
authors: SG
authors: Ma
authors: State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China.
authors: Yong
authors: Y
authors: Li
authors: State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China.
authors: Yun-Bao
authors: YB
authors: Liu
authors: State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China.
authors: Li
authors: L
authors: Li
authors: State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China.
authors: Jing
authors: J
authors: Qu
authors: State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China. Electronic address: yushishan@imm.ac.cn.
authors: Shi-Shan
authors: SS
authors: Yu
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000302:isolation & purification* / Q000494:pharmacology*; D002460:Cell Line; D020128:Inhibitory Concentration 50; D009281:Naphthalenes / Q000302:isolation & purification* / Q000494:pharmacology*; D012639:Seeds / Q000737:chemistry*; D031451:Strychnos / Q000737:chemistry*
chemical_list: D000893:Anti-Inflammatory Agents; D009281:Naphthalenes
keywords: Anti-inflammatory activity; Lactone; Spirobisnaphthalene; Strychnaceae; Strychnos angustiflora