title: Clinical Risk Factors for Gastroduodenal Ulcer in Romanian Low-Dose Aspirin Consumers.
abstract: Background. Aspirin use for cardiovascular or cancer prevention is limited due to its gastrointestinal side effects. Objective. Our prospective, observational case-control study aims to identify the predictive factors for ulcers in low-dose aspirin consumers (75-325 mg/day). Methods. The study included patients who underwent an upper digestive endoscopy and took low-dose aspirin treatment. Results. We recruited 51 patients with ulcer (ulcer group) and 108 patients with no mucosal lesions (control group). In univariate analysis, factors significantly associated with ulcers were male gender (p = 0.001), anticoagulants (p = 0.029), nonsteroidal anti-inflammatory drugs (p = 0.013), heart failure (p = 0.007), liver (p = 0.011) or cerebrovascular disease (p = 0.004), diabetes mellitus (p = 0.043), ulcer history (p = 0.044), and alcohol consumption (p = 0.018), but not Helicobacter pylori infection (p = 0.2). According to our multivariate regression analysis results, history of peptic ulcer (OR 3.07, 95% CI 1.06-8.86), cotreatment with NSAIDs (OR 8, 95% CI 2.09-30.58) or anticoagulants (OR 4.85, 95% CI 1.33-17.68), male gender (OR 5.2, 95% CI 1.77-15.34), and stroke (OR 7.27, 95% CI 1.40-37.74) remained predictors for ulcer on endoscopy. Conclusions. Concomitant use of NSAIDs or anticoagulants, comorbidities (cerebrovascular disease), and male gender are the most important independent risk factors for ulcer on endoscopy in low-dose aspirin consumers, in a population with a high prevalence of H. pylori infection.
authors: University of Medicine and Pharmacy, Tirgu Mureș, Gheorghe Marinescu 38, 540139 Mures, Romania.
authors: Anca
authors: 0000-0003-2115-6576
authors: A
authors: Negovan
authors: University of Medicine and Pharmacy "Iuliu Hațieganu" Cluj-Napoca, 8 Victor Babeş, 400012 Cluj-Napoca, Romania.
authors: Mihaela
authors: 0000-0002-4557-5364
authors: M
authors: Iancu
authors: University of Medicine and Pharmacy, Tirgu Mureș, Gheorghe Marinescu 38, 540139 Mures, Romania.
authors: Valeriu
authors: V
authors: Moldovan
authors: University of Medicine and Pharmacy, Tirgu Mureș, Gheorghe Marinescu 38, 540139 Mures, Romania.
authors: Septimiu
authors: 0000-0002-6467-6275
authors: S
authors: Voidazan
authors: University of Medicine and Pharmacy, Tirgu Mureș, Gheorghe Marinescu 38, 540139 Mures, Romania.
authors: Simona
authors: S
authors: Bataga
authors: University of Medicine and Pharmacy, Tirgu Mureș, Gheorghe Marinescu 38, 540139 Mures, Romania.
authors: Monica
authors: M
authors: Pantea
authors: Emergency County Hospital, Tirgu Mures, Gheorghe Marinescu 50, 540136 Mures, Romania.
authors: Kinga
authors: K
authors: Sarkany
authors: University of Medicine and Pharmacy, Tirgu Mureș, Gheorghe Marinescu 38, 540139 Mures, Romania.
authors: Cristina
authors: C
authors: Tatar
authors: Emergency County Hospital, Tirgu Mures, Gheorghe Marinescu 50, 540136 Mures, Romania.
authors: Simona
authors: S
authors: Mocan
authors: University of Medicine and Pharmacy, Tirgu Mureș, Gheorghe Marinescu 38, 540139 Mures, Romania.
authors: Claudia
authors: 0000-0002-3235-524X
authors: C
authors: Banescu