title: Comparative study of peripheral nerve Mri and ultrasound in multifocal motor neuropathy and amyotrophic lateral sclerosis.
abstract: Differentiating multifocal motor neuropathy (MMN) from amyotrophic lateral sclerosis (ALS) is important, as MMN is a difficult, but treatable disorder.
  
  
  
  We studied peripheral nerve imaging techniques in differentiating MMN from ALS by measuring the cross-sectional area (CSA) of the median and ulnar nerves in the forearms using high resolution ultrasound (HRUS) and MRI.
  
  
  
  HRUS CSA values of the median nerve in the forearm (P = 0.002) and the ulnar nerve distal to the sulcus (P = 0.009) were significantly enlarged in patients with MMN. There was a positive correlation between CSA as measured with HRUS and MRI (Spearman rho 0.60; P < 0.001).
  
  
  
  Peripheral nerve imaging is a potentially powerful technique to distinguish MMN from ALS. Muscle Nerve, 2016 Muscle Nerve 54: 1133-1135, 2016.
authors: Brain Centre Rudolf Magnus, Department of Neurology and Neurosurgery, University Medical Centre Utrecht, Room F02.230, P.O. Box 85500, 3508 GA, Utrecht, The Netherlands.
authors: Bas A
authors: BA
authors: Jongbloed
authors: Department of Radiology, University Medical Centre Utrecht, Utrecht, The Netherlands.
authors: Wieke
authors: W
authors: Haakma
authors: Brain Centre Rudolf Magnus, Department of Neurology and Neurosurgery, University Medical Centre Utrecht, Room F02.230, P.O. Box 85500, 3508 GA, Utrecht, The Netherlands.
authors: H Stephan
authors: HS
authors: Goedee
authors: Brain Centre Rudolf Magnus, Department of Neurology and Neurosurgery, University Medical Centre Utrecht, Room F02.230, P.O. Box 85500, 3508 GA, Utrecht, The Netherlands.
authors: Jeroen W
authors: JW
authors: Bos
authors: Department of Radiology, University Medical Centre Utrecht, Utrecht, The Netherlands.
authors: Clemens
authors: C
authors: Bos
authors: Department of Radiology, University Medical Centre Utrecht, Utrecht, The Netherlands.
authors: Jeroen
authors: J
authors: Hendrikse
authors: Brain Centre Rudolf Magnus, Department of Neurology and Neurosurgery, University Medical Centre Utrecht, Room F02.230, P.O. Box 85500, 3508 GA, Utrecht, The Netherlands.
authors: Leonard H
authors: LH
authors: Van Den Berg
authors: Brain Centre Rudolf Magnus, Department of Neurology and Neurosurgery, University Medical Centre Utrecht, Room F02.230, P.O. Box 85500, 3508 GA, Utrecht, The Netherlands.
authors: W Ludo
authors: WL
authors: Van Der Pol
mesh_terms: D000328:Adult; D000368:Aged; D000690:Amyotrophic Lateral Sclerosis / Q000000981:diagnostic imaging*; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009431:Neural Conduction; D010525:Peripheral Nerves / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D011115:Polyneuropathies / Q000000981:diagnostic imaging*; D018709:Statistics, Nonparametric; D014463:Ultrasonography
keywords: ALS; HRUS; MMN; MRI; peripheral nerve