title: Correlations of magnetic resonance, perfusion-weighed imaging parameters and microvessel density in meningioma.
abstract: OBJECTIVE
  To investigate the correlations of magnetic resonance, perfusion-weighed imaging (PWI) parameters and microvessel density (MVD) in meningioma.
  
  
  METHODS
  48 patients with pathologically confirmed meningioma (grade I, 38 cases; grade II+III, 10 cases) completed preoperative routine magnetic resonance imaging (MRI) and PWI. The cerebral blood volume (CBV) map of solid tumor region and the mean of maximum relative cerebral blood volume (rCBV) were then calculated. Immunohistochemical staining was performed in all specimens to measure the MVD.
  
  
  RESULTS
  On the CBV map, benign meningiomas showed a high perfusion signal, while malignant meningiomas exhibited a slightly higher one. The rCBV of benign meningiomas was 9.61±4.76, which was significantly higher than 3.61±0.25 of malignant meningiomas (t=7.165, p=0.000). The MVD of benign meningioma strips was 21.16 ± 11.32, which was also significantly higher than 10.71 ± 5.53 strips of malignant meningiomas (t=2.325, p=0.026). The correlation analysis showed that the mean of maximum rCBV and MVD of meningiomas had significant positive correlations (r=0.718, p=0.000).
  
  
  CONCLUSIONS
  The CBV map of benign meningiomas is different to that of malignant meningiomas, and the mean of maximum rCBV and MVD have significant positive correlations.
authors: Department of Radiology, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, China.
authors: Ruihua
authors: R
authors: Shi
authors: Tao
authors: T
authors: Jiang
authors: Lifang
authors: L
authors: Si
authors: Min
authors: M
authors: Li
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001810:Blood Volume; D002648:Child; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008577:Meningeal Neoplasms / Q000098:blood supply / Q000000981:diagnostic imaging* / Q000473:pathology; D008579:Meningioma / Q000098:blood supply / Q000000981:diagnostic imaging* / Q000473:pathology; D055806:Microvessels / Q000473:pathology*; D008875:Middle Aged; D055420:Perfusion Imaging / Q000379:methods*