title: Evaluation of Adenosine Triphosphate-Binding Cassette Transporter A1 (ABCA1) R219K and C-Reactive Protein Gene (CRP) +1059G/C Gene Polymorphisms in Susceptibility to Coronary Heart Disease.
abstract: BACKGROUND This meta-analysis investigated the correlation of ABCA1 R219K and C-Reactive Protein Gene (CRP) +1059G/C gene polymorphisms with susceptibility to coronary heart disease (CHD). MATERIAL AND METHODS We searched PubMed, Springer link, Wiley, EBSCO, Ovid, Wanfang database, VIP database, and China National Knowledge Infrastructure (CNKI) databases to retrieve published studies by keyword. Searches were filtered using our stringent inclusion and exclusion criteria. Resultant high-quality data collected from the final selected studies were analyzed using Comprehensive Meta-analysis 2.0 software. Eleven case-control studies involving 3053 CHD patients and 3403 healthy controls met our inclusion criteria. Seven studies were conducted in Asian populations, 3 studies were done in Caucasian populations, and 1 was in an African population. RESULTS Our major finding was that ABCA1 R219K polymorphism increased susceptibility to CHD in allele model (OR=0.729, 95% CI=0.559~0.949, P=0.019) and dominant model (OR=0.698, 95% CI=0.507~0.961, P=0.027). By contrast, we were unable to find any significant association between the CRP +1059G/C polymorphism and susceptibility to CHD (allele model: OR=1.170, 95% CI=0.782~1.751, P=0.444; dominant model: OR=1.175, 95% CI=0.768~1.797, P=0.457). CONCLUSIONS This meta-analysis provides convincing evidence that polymorphism of ABCA1 R219K is associated with susceptibility to CHD while the CRP +1059G/C polymorphism appears to have no correlation with susceptibility to CHD.
authors: Department of Cardiology, Linyi People's Hospital, Linyi, Shandong, China (mainland).
authors: Jing-Fang
authors: JF
authors: Li
authors: Department of General Surgery, People's Hospital of Pingyi County, Linyi, Shandong, China (mainland).
authors: Dian-Ying
authors: DY
authors: Peng
authors: Department of Ophthalmology, People's Hospital of Pingyi County, Linyi, Shandong, China (mainland).
authors: Mei
authors: M
authors: Ling
authors: Department of Internal Neurology, Second Ward, People's Hospital of Pingyi County, Linyi, Shandong, China (mainland).
authors: Yong
authors: Y
authors: Yin
mesh_terms: D064286:ATP Binding Cassette Transporter 1 / Q000235:genetics*; D002097:C-Reactive Protein / Q000235:genetics*; D003327:Coronary Disease / Q000235:genetics*; D005787:Gene Frequency / Q000235:genetics; D018740:Genetic Heterogeneity; D056426:Genetic Loci; D020022:Genetic Predisposition to Disease; D006801:Humans; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D017594:Publication Bias; D012044:Regression Analysis
chemical_list: C577836:ABCA1 protein, human; D064286:ATP Binding Cassette Transporter 1; D002097:C-Reactive Protein