title: High kinetic inertness of a bis-hydrated Gd-complex with a constrained AAZTA-like ligand.
abstract: Kinetic inertness is a key property for a Gd-based contrast agent. The Gd(III) complex of a cyclohexyl-fused AAZTA derivative shows the highest kinetic inertness for non-macrocyclic bis hydrated (q = 2) Gd(III)-complexes with a dissociation half-life of 91 years under physiological conditions, very close to that of macrocyclic clinically approved contrast agents. It also shows optimal relaxometric performance (r1 = 8.3 mM(-1) s(-1) at 20 MHz and 25 °C) due to the presence of two inner sphere water molecules in fast exchange with bulk water and not displaced by endogenous anions.
authors: Department of Inorganic and Analytical Chemistry, University of Debrecen, H-4032, Debrecen, Egyetem tér 1, Hungary.
authors: Adrienn
authors: A
authors: Vágner
authors: Eliana
authors: E
authors: Gianolio
authors: Silvio
authors: S
authors: Aime
authors: Alessandro
authors: A
authors: Maiocchi
authors: Imre
authors: I
authors: Tóth
authors: Zsolt
authors: Z
authors: Baranyai
authors: Lorenzo
authors: L
authors: Tei