title: Prostaglandin versus mechanical dilation and the effect of maternal obesity on failure to achieve active labor: a cohort study.
abstract: OBJECTIVE
  Assess the impact of obesity on successful cervical ripening with mechanical versus prostaglandin ripening.
  
  
  METHODS
  We compared obese to non-obese women in an analysis stratified by induction method, prostaglandin versus mechanical. Misoprostol dosing was the same for obese and non-obese women. Pitocin was titrated to effect. Our primary outcome was failure to achieve active labor. Secondary outcomes included overall cesarean delivery rate, doses of misoprostol used and need for protocol deviation.
  
  
  RESULTS
  Obese women had a higher cesarean delivery rate with misoprostol (35% versus 26%, p = 0.03) but not with mechanical ripening (31% versus 29%, p = 0.69). Obesity was associated with a higher rate of failure to achieve active labor in women undergoing prostaglandin ripening with misoprostol (24 versus 15%, p = 0.01) but not in women undergoing mechanical ripening (19 versus 15%, p = 0.55). After controlling for confounding variables, obese women who underwent cervical ripening with misoprostol had a higher rate of failure to achieve active labor, aOR 1.29 (95%CI: 1.00-1.67), which was not seen with mechanical ripening, aOR 1.09 (95%CI: 0.69-1.73).
  
  
  CONCLUSIONS
  Obese women receiving the same dose of misoprostol as non-obese women have higher rates of failure to achieve active labor, an effect not seen with mechanical ripening.
authors: a Division of Maternal Fetal Medicine , Department of Obstetrics and Gynecology, University of Cincinnati College of Medicine , Cincinnati , OH , USA.
authors: Lindsay
authors: L
authors: Beckwith
authors: b Department of Obstetrics and Gynecology , The Christ Hospital , Cincinnati , OH , USA , and.
authors: Kristin
authors: K
authors: Magner
authors: c Department of Obstetrics and Gynecology , Northwestern Medicine , Chicago , IL , USA.
authors: Sara
authors: S
authors: Kritzer
authors: a Division of Maternal Fetal Medicine , Department of Obstetrics and Gynecology, University of Cincinnati College of Medicine , Cincinnati , OH , USA.
authors: Carri R
authors: CR
authors: Warshak
mesh_terms: D000282:Administration, Intravaginal; D016022:Case-Control Studies; D020070:Cervical Ripening / Q000187:drug effects; D002585:Cesarean Section / Q000706:statistics & numerical data; D004106:Dilatation / Q000379:methods; D005260:Female; D006801:Humans; D007751:Labor, Induced / Q000379:methods*; D016595:Misoprostol / Q000008:administration & dosage*; D009765:Obesity; D007744:Obstetric Labor Complications; D010120:Oxytocics; D010121:Oxytocin / Q000008:administration & dosage*; D011247:Pregnancy; D011248:Pregnancy Complications; D012189:Retrospective Studies; D017211:Treatment Failure
chemical_list: D010120:Oxytocics; D016595:Misoprostol; D010121:Oxytocin
keywords: Misoprostol; cervical ripening; induction; obesity