title: Dysexecutive syndrome in Parkinson's disease: the GREFEX study.
abstract: The objectives of this study were to characterize the frequencies and profiles of behavioral and cognitive dysexecutive syndromes in PD (based on validated battery and diagnostic criteria) and to develop a shortened diagnostic battery. Eighty-eight non-demented patients with a diagnosis of PD were examined with an executive validated battery. Using a validated framework, the patients' test results were interpreted with respect to normative data from 780 controls. A dysexecutive syndrome was observed in 80.6% of the patients [95% confidence interval: 71.1-90.1]. The dysexecutive profile was characterized by prominent impairments in deduction, flexibility, inhibition and initiation in the cognitive domain, and by global hypoactivity with apathy and hyperactivity in the behavioral domain. This finding implies that patients with PD should be assessed with cognitive tests and a validated inventory for behavioral dysexecutive syndromes. A shortened battery (based on three cognitive tests and three behavioral domains) provided high diagnostic accuracy.
authors: a Department of Neurology and Laboratory of Functional Neurosciences EA 4559, SFR CAP-Santé (FED 4231) , University Hospital of Amiens , Amiens , France.
authors: Martine
authors: M
authors: Roussel
authors: b Department of Neurology, Movement Disorder Unit, Inserm, U836 , University Hospital of Grenoble , Grenoble , France.
authors: Eugénie
authors: E
authors: Lhommée
authors: a Department of Neurology and Laboratory of Functional Neurosciences EA 4559, SFR CAP-Santé (FED 4231) , University Hospital of Amiens , Amiens , France.|c Department of Psychology Descartes , University of Paris , Paris , France.
authors: Pauline
authors: P
authors: Narme
authors: d Department of Neurology , University Hospital of Paris La Salpétrière , Paris , France.
authors: Virginie
authors: V
authors: Czernecki
authors: e Department of Psychology and Neurology , University Hospital of Angers , Angers , France.
authors: Didier Le
authors: DL
authors: Gall
authors: a Department of Neurology and Laboratory of Functional Neurosciences EA 4559, SFR CAP-Santé (FED 4231) , University Hospital of Amiens , Amiens , France.
authors: Pierre
authors: P
authors: Krystkowiak
authors: f Department of Biostatistics , University Hospital of Amiens , Amiens , France.
authors: Momar
authors: M
authors: Diouf
authors: a Department of Neurology and Laboratory of Functional Neurosciences EA 4559, SFR CAP-Santé (FED 4231) , University Hospital of Amiens , Amiens , France.
authors: Olivier
authors: O
authors: Godefroy
mesh_terms: D000977:Antiparasitic Agents / Q000627:therapeutic use; D003072:Cognition Disorders / Q000175:diagnosis / Q000209:etiology*; D056344:Executive Function; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy / Q000523:psychology*; D011569:Psychiatric Status Rating Scales; D012680:Sensitivity and Specificity; D012720:Severity of Illness Index
chemical_list: D000977:Antiparasitic Agents
keywords: Executive functions; Parkinson’s disease; behavioral disorders; dementia; mild cognitive impairment