title: Efficacy of buprenorphine added to 2% lignocaine plus adrenaline 1:80,000 in providing postoperative analgesia after lower third molar surgery.
abstract: A number of trials have examined the peripheral analgesic effect of opioids, known to have an anti-nociceptive effect at the central and/or spinal cord level. This study aimed to evaluate the efficacy of buprenorphine added to 2% lignocaine with adrenaline 1:80,000 in providing postoperative analgesia after lower third molar surgery. Sixty patients were randomized to three groups: group A received lignocaine 2% with adrenaline 1:80,000 for inferior alveolar nerve block (IANB), along with intramuscular (IM) injection of 1ml saline; group B received buprenorphine mixed with lignocaine 2% with adrenaline 1:80,000 for IANB (0.01mg buprenorphine/ml lignocaine with adrenaline), along with 1ml saline IM; group C received lignocaine 2% with adrenaline 1:80,000 for IANB, along with 0.03mg buprenorphine IM. Mean postoperative pain scores (visual analogue scale; when the patient first felt pain) were 6.0 for group A, 1.0 for group B, and 4.4 for group C. The mean duration of postoperative analgesia was 3.5h in groups A and C and 12h in group B. The mean number of postoperative analgesics consumed was 5.8 in groups A and C and 3.9 in group B. The addition of buprenorphine (0.03mg) to 2% lignocaine with adrenaline 1:80,000 significantly reduced the severity of postoperative pain and prolonged the duration of analgesia, thereby decreasing the need for postoperative analgesics.
authors: Department of Oral and Maxillofacial Surgery, JN Kapoor DAV [C] Dental College and Hospital, Yamunanagar, Haryana, India. Electronic address: naveenprisha@gmail.com.
authors: N
authors: N
authors: Chhabra
authors: Department of Oral and Maxillofacial Surgery, JN Kapoor DAV [C] Dental College and Hospital, Yamunanagar, Haryana, India.
authors: P
authors: P
authors: Sharma
authors: Department of Oral and Maxillofacial Surgery, JN Kapoor DAV [C] Dental College and Hospital, Yamunanagar, Haryana, India.
authors: S
authors: S
authors: Chhabra
authors: Department of Oral and Maxillofacial Surgery, JN Kapoor DAV [C] Dental College and Hospital, Yamunanagar, Haryana, India.
authors: N
authors: N
authors: Gupta
mesh_terms: D000328:Adult; D000698:Analgesia; D000701:Analgesics, Opioid; D000779:Anesthetics, Local / Q000008:administration & dosage*; D002047:Buprenorphine / Q000008:administration & dosage*; D004311:Double-Blind Method; D004837:Epinephrine / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D008012:Lidocaine / Q000008:administration & dosage*; D008297:Male; D008964:Molar, Third / Q000601:surgery*; D010149:Postoperative Pain / Q000188:drug therapy*; D014081:Tooth Extraction / Q000009:adverse effects*
chemical_list: D000701:Analgesics, Opioid; D000779:Anesthetics, Local; D002047:Buprenorphine; D008012:Lidocaine; D004837:Epinephrine
keywords: local analgesia; opioid analgesics; postoperative pain