title: Study design for a randomized controlled trial to increase the relative reinforcing value of vegetable consumption using incentive sensitization among obese and overweight people.
abstract: In this manuscript, we present the protocol for a study that applies incentive sensitization theory to improve vegetable intake in overweight and obese adults. This 8-week, randomized, controlled, community-based feeding study with an 8-week follow-up seeks to use repeated exposure to amounts of vegetables recommended by federal guidance to increase the primary outcome of the relative reinforcing value of vegetables compared to a snack food. A community-based design is used to give participants autonomy in choosing their method of exposure. Secondary outcomes include: 1) Determine potential moderators of incentive sensitization of vegetables, including genetic polymorphisms associated with food reinforcement and obesity, 6-n-propylthiouracil tasting status, and delay discounting. 2) Determine whether adding vegetables to the diet results in participants substituting low-energy-dense vegetables for energy-dense foods or whether energy-dense food consumption is independent of vegetable consumption. 3) Determine whether reductions in adiposity are associated with substitution of vegetables in the diet. 4) Determine if markers of bone turnover change. 5) Assess changes in self-reported secondary outcomes measured by questionnaire such as self-efficacy to eat vegetables. The results of this study will provide information about the drivers of individual choice to consume recommended amounts of vegetables. The understanding gained will help increase the effectiveness and sustainability of behavior-based interventions focused on improving vegetable intake. This information may also be used to assist in setting dietary guidance targets for the amounts and types of vegetables Americans can, and should, consume.
authors: United States Department of Agriculture, Agricultural Research Service, Grand Forks Human Nutrition Research Center, 2420 2nd Ave N, Grand Forks, ND 58203, USA. Electronic address: lisa.jahns@ars.usda.gov.
authors: Lisa
authors: L
authors: Jahns
authors: United States Department of Agriculture, Agricultural Research Service, Grand Forks Human Nutrition Research Center, 2420 2nd Ave N, Grand Forks, ND 58203, USA. Electronic address: james.roemmich@ars.usda.gov.
authors: James N
authors: JN
authors: Roemmich
mesh_terms: D050154:Adiposity; D016723:Bone Remodeling / Q000502:physiology; D055812:Community-Based Participatory Research; D004032:Diet; D005247:Feeding Behavior / Q000523:psychology; D005518:Food Preferences / Q000523:psychology*; D006801:Humans; D009042:Motivation; D009765:Obesity / Q000235:genetics / Q000523:psychology; D050177:Overweight / Q000235:genetics* / Q000523:psychology*; D020641:Polymorphism, Single Nucleotide; D011441:Propylthiouracil / Q000378:metabolism; D012054:Reinforcement, Psychology; D012107:Research Design; D020377:Self Efficacy; D012944:Social Support; D014675:Vegetables
chemical_list: D011441:Propylthiouracil
keywords: Food reinforcement; Randomized controlled trial; Relative reinforcing value; Self-efficacy; Substitution; Vegetables