title: Highly Pathogenic Reassortant Avian Influenza A(H5N1) Virus Clade 2.3.2.1a in Poultry, Bhutan.
abstract: Highly pathogenic avian influenza A(H5N1), clade 2.3.2.1a, with an H9-like polymerase basic protein 1 gene, isolated in Bhutan in 2012, replicated faster in vitro than its H5N1 parental genotype and was transmitted more efficiently in a chicken model. These properties likely help limit/eradicate outbreaks, combined with strict control measures.
authors: Atanaska
authors: A
authors: Marinova-Petkova
authors: John
authors: J
authors: Franks
authors: Sangay
authors: S
authors: Tenzin
authors: Narapati
authors: N
authors: Dahal
authors: Kinzang
authors: K
authors: Dukpa
authors: Jambay
authors: J
authors: Dorjee
authors: Mohammed M
authors: MM
authors: Feeroz
authors: Jerold E
authors: JE
authors: Rehg
authors: Subrata
authors: S
authors: Barman
authors: Scott
authors: S
authors: Krauss
authors: Pamela
authors: P
authors: McKenzie
authors: Richard J
authors: RJ
authors: Webby
authors: Robert G
authors: RG
authors: Webster
mesh_terms: D000818:Animals; D001631:Bhutan / Q000453:epidemiology; D004196:Disease Outbreaks; D005838:Genotype; D062306:Geography, Medical; D006801:Humans; D053124:Influenza A Virus, H5N1 Subtype / Q000145:classification* / Q000235:genetics*; D005585:Influenza in Birds / Q000453:epidemiology* / Q000821:virology*; D007251:Influenza, Human / Q000453:epidemiology; D010802:Phylogeny; D011200:Poultry / Q000821:virology*; D016865:Reassortant Viruses / Q000235:genetics*; D012306:Risk
keywords: Bhutan; Indian subcontinent; avian influenza; clade 2.3.2.1a; ferret model: respiratory diseases; highly pathogenic avian influenza H5N1; influenza; influenza virus; outbreak; reassortant; transmission; viruses; zoonoses