title: Long-term follow-up of transplantation of preserved limbal allograft and amniotic membrane for recurrent pterygium.
abstract: OBJECTIVE
  To conduct a long-term follow-up study evaluating the efficacy and safety of transplantation of preserved limbal allograft and amniotic membrane for recurrent pterygium.
  
  
  METHODS
  This was a retrospective, non-comparative, interventional case series conducted at a private eye hospital. Eighty-four eyes of 80 patients with recurrent pterygium were included in the study. The mean number of previous surgeries for pterygium was 1.36 ± 0.98 (range, 1-8). All subjects received transplantation of preserved limbal allograft and amniotic membrane.
  
  
  RESULTS
  The mean follow-up period was 73.0 ± 38.1 months (range, 12-154 months). Pterygium recurred in 10 eyes (11.9 %). The mean period to recurrence was 16.3 ± 11.3 months (range, 5-33 months). Symblepharon was cured in 21 eyes, persisted in 2 eyes, and newly occurred in 3 eyes. Diplopia was cured in eight eyes, persisted in five eyes, and newly occurred in one eye. As for complications, intraocular pressure elevations over 21 mmHg were recognized in ten eyes of nine cases, in which the intraocular pressure was controlled by reduction of topical steroid in four eyes and by addition of topical prostaglandin derivatives in six eyes. Twenty-four eyes (28.6 %) gained two lines or more of Landolt best spectacle-corrected visual acuity (BSCVA), 56 eyes (66.7 %) stayed within one line from preoperation, and four eyes (4.8 %) lost two lines or more. There were no major complications and no graft rejection.
  
  
  CONCLUSIONS
  Transplantation of preserved limbal allograft and amniotic membrane is a safe and effective procedure for recurrent pterygium.
authors: Miyata Eye Hospital, 6-3 Kuraharacho, Miyakonojo, Miyazaki, 885-0051, Japan.
authors: Takashi
authors: T
authors: Ono
authors: Miyata Eye Hospital, 6-3 Kuraharacho, Miyakonojo, Miyazaki, 885-0051, Japan.
authors: Yosai
authors: Y
authors: Mori
authors: Miyata Eye Hospital, 6-3 Kuraharacho, Miyakonojo, Miyazaki, 885-0051, Japan.
authors: Ryohei
authors: R
authors: Nejima
authors: Miyata Eye Hospital, 6-3 Kuraharacho, Miyakonojo, Miyazaki, 885-0051, Japan.
authors: Tadatoshi
authors: T
authors: Tokunaga
authors: Miyata Eye Hospital, 6-3 Kuraharacho, Miyakonojo, Miyazaki, 885-0051, Japan.
authors: Kazunori
authors: K
authors: Miyata
authors: Inouye Eye Hospital, 4-3 Kandasurugadai, Chiyoda-ku, Tokyo, 101-0062, Japan. amanoshiro1126@gmail.com.
authors: Shiro
authors: http://orcid.org/0000-0003-0472-851X
authors: S
authors: Amano
mesh_terms: D000287:Administration, Topical; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D064591:Allografts; D000650:Amnion / Q000637:transplantation*; D001623:Betamethasone / Q000008:administration & dosage; D001684:Biological Dressings; D016039:Corneal Transplantation / Q000379:methods*; D005260:Female; D005469:Fluorometholone / Q000008:administration & dosage; D005500:Follow-Up Studies; D005938:Glucocorticoids / Q000008:administration & dosage; D006084:Graft Rejection / Q000175:diagnosis / Q000188:drug therapy; D006801:Humans; D016850:Limbus Corneae / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D011625:Pterygium / Q000175:diagnosis / Q000601:surgery*; D012008:Recurrence; D012189:Retrospective Studies; D013997:Time Factors; D016896:Treatment Outcome; D014792:Visual Acuity
chemical_list: D005938:Glucocorticoids; D001623:Betamethasone; D005469:Fluorometholone
keywords: Amniotic membrane; Limbal allograft; Mitomycin C; Recurrent pterygium