title: Polymorphisms FTO rs9939609, PPARG rs1801282 and ADIPOQ rs4632532 and rs182052 but not lifestyle are associated with obesity related-traits in Mexican children.
abstract: Concerning the genetic factors of obesity, no consistent association between populations has been reported, which may be due to the frequency of polymorphisms, the lifestyle of studied populations and its interaction with other factors. We studied a possible association of polymorphisms FTO rs9939609, PPARG rs1801282, and ADIPOQ rs4632532 and rs182052 with obesity phenotypes in 215 Mexican children. Glucose, triglycerides, cholesterol, HDL and LDL were measured. In addition, weight, height, waist circumference and triceps skin thickness were recorded. High-energy diets and sedentary behavior were evaluated with a validated questionnaire. In contrast with other reports, only FTO rs9939609 was associated with obesity related-traits, including BMI (p = 0.03), waist circumference (p = 0.02), triceps skinfold (p = 0.03) and waist/height ratio (p = 0.01), and also with cholesterol levels (p = 0.02) and LDL (p = 0.009). Lower levels of triglycerides (p=0.04) were related with presence of PPARG rs1801282, while ADIPOQ rs4632532 showed an effect on HDL (p = 0.03) levels. On the other hand, diet, physical activity and screen time were not related with obesity. In summary, only FTO rs9939609 was associated with obesity related-traits, while PPARG2 rs1801282 and ADIPOQ rs4632532 were involved in lipid metabolism.
authors: Departamento de Investigación, Facultad de Medicina, Universidad Juárez del Estado de Durango, Durango, México.
authors: C
authors: C
authors: Muñoz-Yáñez
authors: Departamento de Biología Molecular, Facultad de Ciencias Químicas, Universidad Juárez del Estado de Durango, Durango, México.
authors: R
authors: R
authors: Pérez-Morales
authors: Departamento de Economía, División CSH de la Universidad Autónoma Metropolitana, Unidad Iztapalapa, D.F. México, México.
authors: H
authors: H
authors: Moreno-Macías
authors: Departamento de Biología Molecular, Facultad de Ciencias Químicas, Universidad Juárez del Estado de Durango, Durango, México.
authors: E
authors: E
authors: Calleros-Rincón
authors: Facultad de Ciencias, Universidad Autónoma del Estado de Morelos, Cuernavaca, Morelos, México.
authors: G
authors: G
authors: Ballesteros
authors: Facultad de Ciencias, Universidad Autónoma del Estado de Morelos, Cuernavaca, Morelos, México.
authors: R A
authors: RA
authors: González
authors: Departamento de Investigación, Facultad de Medicina, Universidad Juárez del Estado de Durango, Durango, México.
authors: J
authors: J
authors: Espinosa