title: Comparison of mesenchymal stem cells and leukocytes from Large White and Göttingen Minipigs: Clues for stem cell-based immunomodulatory therapies.
abstract: The mesenchymal stem cells (MSCs) are one of the most promising cell types for human and veterinary use and their therapeutic effect is associated with their immunomodulatory properties. Farm animal models, such as pigs, have become a valuable tool to evaluate the safety and efficacy of adoptively transferred MSCs in the setting of veterinary medicine. In order to evaluate the immunomodulatory effect of stem cell-based therapies in porcine breeds, a deep analysis and comparison of MSCs and leukocyte subsets are absolutely necessary. Here we provide a detailed analysis of bone-marrow derived MSCs and leukocyte subsets from Large White pigs and Göttingen Minipigs. Significant differences were observed between the two pig breeds in terms of T cell subsets that need to be considered for immune monitoring of stem cell-based therapies.
authors: Stem Cell Therapy Unit, Minimally Invasive Surgery Centre, 10071 Caceres, Spain. Electronic address: valvarez@ccmijesususon.com.
authors: Verónica
authors: V
authors: Álvarez
authors: Stem Cell Therapy Unit, Minimally Invasive Surgery Centre, 10071 Caceres, Spain. Electronic address: msanchez@ccmijesususon.com.
authors: Francisco-Miguel
authors: FM
authors: Sánchez-Margallo
authors: Stem Cell Therapy Unit, Minimally Invasive Surgery Centre, 10071 Caceres, Spain. Electronic address: rblazquez@ccmijesususon.com.
authors: Rebeca
authors: R
authors: Blázquez
authors: Immunology Unit, Department of Physiology, University of Extremadura, 10071 Caceres, Spain. Electronic address: rtarazon@unex.es.
authors: Raquel
authors: R
authors: Tarazona
authors: Stem Cell Therapy Unit, Minimally Invasive Surgery Centre, 10071 Caceres, Spain. Electronic address: jgarcia@ccmijesususon.com.
authors: Javier G
authors: JG
authors: Casado
mesh_terms: D000818:Animals; D001853:Bone Marrow / Q000276:immunology; D056747:Immunomodulation; D007694:Killer Cells, Natural / Q000276:immunology; D007962:Leukocytes / Q000276:immunology*; D045164:Mesenchymal Stem Cell Transplantation; D013552:Swine; D013556:Swine, Miniature
keywords: Leukocytes; Lymphocytes; Mesenchymal stem cells; Pig