title: Roles of Reactive Oxygen Species in Anticancer Therapy with Salvia miltiorrhiza Bunge.
abstract: Cancer is a leading cause of death worldwide. We aim to provide a systematic review about the roles of reactive oxygen species (ROS) in anticancer therapy with Salvia miltiorrhiza Bunge (Danshen). Danshen, including its lipophilic and hydrophilic constituents, is potentially beneficial for treating various cancers. The mechanisms of ROS-related anticancer effects of Danshen vary depending on the specific type of cancer cells involved. Danshen may enhance TNF-α-induced apoptosis, upregulate caspase-3, caspase-8, caspase-9, endoplasmic reticulum stress, P21, P53, Bax/Bcl-2, DR5, and AMP-activated protein kinase, or activate the p38/JNK, mitogen-activated protein kinase, and FasL signaling pathways. Conversely, Danshen may downregulate human telomerase reverse transcriptase mRNA, telomerase, survivin, vascular endothelial growth factor/vascular endothelial growth factor receptor 2, CD31, NF-κB, Erk1/2, matrix metalloproteinases, microtubule assembly, and receptor tyrosine kinases including epidermal growth factor receptors, HER2, and P-glycoprotein and inhibit the PI3K/Akt/mTOR or estrogen receptor signaling pathways. Therefore, Danshen may inhibit cancer cells proliferation through antioxidation on tumor initiation and induce apoptosis or autophagy through ROS generation on tumor progression, tumor promotion, and tumor metastasis. Based on the available evidence regarding its anticancer properties, this review provides new insights for further anticancer research or clinical trials with Danshen.
authors: Department of Chinese Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, No. 123, Dapi Road, Niaosong District, Kaohsiung 83342, Taiwan; School of Chinese Medicine for Post Baccalaureate, I-Shou University, No. 1, Sec. 1, Syuecheng Road, Dashu District, Kaohsiung 84001, Taiwan.
authors: Yu-Chiang
authors: 0000-0001-7490-4465
authors: YC
authors: Hung
authors: School of Traditional Chinese Medicine, Chang Gung University, No. 259 Wen-Hwa 1st Road, Kweishan, Taoyuan 33302, Taiwan; Liver Research Center, Chang Gung Memorial Hospital, No. 259 Wen-Hwa 1st Road, Kweishan, Taoyuan 33302, Taiwan; Research Center for Industry of Human Ecology, Chang Gung University of Science and Technology, Kweishan, Taoyuan 83302, Taiwan; Department of Medical Research, China Medical University Hospital, China Medical University, No. 91 Hsush-Shih Road, Taichung 40402, Taiwan.
authors: Tai-Long
authors: TL
authors: Pan
authors: Department of Chinese Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, No. 123, Dapi Road, Niaosong District, Kaohsiung 83342, Taiwan; Kaohsiung Medical University College of Medicine, No. 100, Shihcyuan 1st Road, Sanmin District, Kaohsiung 807, Taiwan; Fooyin University College of Nursing, No. 151, Chinhsueh Road, Ta-Liao District, Kaohsiung 831, Taiwan.
authors: Wen-Long
authors: 0000-0001-9549-6202
authors: WL
authors: Hu
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D057927:Hydrophobic and Hydrophilic Interactions; D009369:Neoplasms / Q000188:drug therapy / Q000378:metabolism; D017382:Reactive Oxygen Species / Q000378:metabolism*; D027561:Salvia miltiorrhiza / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D004365:Drugs, Chinese Herbal; D017382:Reactive Oxygen Species; C028972:dan-shen root extract