title: Erlotinib synergizes with the poly(ADP-ribose) glycohydrolase inhibitor ethacridine in acute myeloid leukemia cells.
authors: Princess Margaret Cancer Centre, Ontario Cancer Institute, University Health Network, Toronto, ON, Canada.|Institute of Medical Science, University of Toronto, ON, Canada.
authors: Lianne E
authors: LE
authors: Rotin
authors: Princess Margaret Cancer Centre, Ontario Cancer Institute, University Health Network, Toronto, ON, Canada.
authors: Neil
authors: N
authors: MacLean
authors: Drug Discovery Program, Ontario Institute for Cancer Research, Toronto, ON, Canada.
authors: Ahmed
authors: A
authors: Aman
authors: Princess Margaret Cancer Centre, Ontario Cancer Institute, University Health Network, Toronto, ON, Canada.
authors: Marcela
authors: M
authors: Gronda
authors: Princess Margaret Cancer Centre, Ontario Cancer Institute, University Health Network, Toronto, ON, Canada.
authors: Feng-Hsu
authors: FH
authors: Lin
authors: Princess Margaret Cancer Centre, Ontario Cancer Institute, University Health Network, Toronto, ON, Canada.
authors: Rose
authors: R
authors: Hurren
authors: Princess Margaret Cancer Centre, Ontario Cancer Institute, University Health Network, Toronto, ON, Canada.
authors: XiaoMing
authors: X
authors: Wang
authors: Samuel Lunenfeld Research Institute, Toronto, ON, Canada.
authors: Jeffrey L
authors: JL
authors: Wrana
authors: Samuel Lunenfeld Research Institute, Toronto, ON, Canada.|Department of Agricultural, Food, and Environmental Sciences, University of Perugia, Italy.
authors: Alessandro
authors: A
authors: Datti
authors: Drug Discovery Program, Ontario Institute for Cancer Research, Toronto, ON, Canada.|Department of Pharmacology and Toxicology, University of Toronto, ON, Canada.
authors: Rima
authors: R
authors: Al-Awar
authors: Princess Margaret Cancer Centre, Ontario Cancer Institute, University Health Network, Toronto, ON, Canada.|Institute of Medical Science, University of Toronto, ON, Canada.
authors: Mark D
authors: MD
authors: Minden
authors: Princess Margaret Cancer Centre, Ontario Cancer Institute, University Health Network, Toronto, ON, Canada aaron.schimmer@utoronto.ca.|Institute of Medical Science, University of Toronto, ON, Canada.
authors: Aaron D
authors: AD
authors: Schimmer
mesh_terms: D045744:Cell Line, Tumor; D004357:Drug Synergism; D000069347:Erlotinib Hydrochloride / Q000494:pharmacology* / Q000627:therapeutic use; D004975:Ethacridine / Q000494:pharmacology* / Q000627:therapeutic use; D006026:Glycoside Hydrolases / Q000037:antagonists & inhibitors; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000188:drug therapy / Q000473:pathology*
chemical_list: D000069347:Erlotinib Hydrochloride; D006026:Glycoside Hydrolases; C022407:poly ADP-ribose glycohydrolase; D004975:Ethacridine