title: Cluster of human parechovirus infections as the predominant cause of sepsis in neonates and infants, Leicester, United Kingdom, 8 May to 2 August 2016.
abstract: We report an unusually high number of cases (n = 26) of parechovirus infections in the cerebrospinal fluid (CSF) of neonates and infants admitted with sepsis in the United Kingdom during 8 May to 2 August 2016. Although such infections in neonates and infants are well-documented, parechovirus has not been routinely included in many in-house and commercial PCR assays for CSF testing. Clinicians should consider routine parechovirus testing in young children presenting with sepsis.
authors: Clinical Microbiology and Virology, University Hospitals of Leicester NHS Trust, Leicester, United Kingdom.
authors: Julian W
authors: JW
authors: Tang
authors: Christopher W
authors: CW
authors: Holmes
authors: Fadwa A
authors: FA
authors: Elsanousi
authors: Ayushi
authors: A
authors: Patel
authors: Fazila
authors: F
authors: Adam
authors: Rachel
authors: R
authors: Speight
authors: Savitha
authors: S
authors: Shenoy
authors: Daniel
authors: D
authors: Bronnert
authors: Gary
authors: G
authors: Stiefel
authors: Premkumar
authors: P
authors: Sundaram
authors: Suchandra
authors: S
authors: Pande
authors: Arani
authors: A
authors: Sridhar
authors: Venkatesh
authors: V
authors: Kairamkonda
authors: Srini
authors: S
authors: Bandi
mesh_terms: D002555:Cerebrospinal Fluid / Q000821:virology*; D005260:Female; D005838:Genotype; D006760:Hospitalization; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007902:Length of Stay / Q000706:statistics & numerical data; D008297:Male; D030061:Parechovirus / Q000235:genetics / Q000302:isolation & purification*; D010850:Picornaviridae Infections / Q000175:diagnosis* / Q000453:epidemiology / Q000821:virology; D012367:RNA, Viral; D020133:Reverse Transcriptase Polymerase Chain Reaction; D018805:Sepsis / Q000453:epidemiology* / Q000821:virology*; D017422:Sequence Analysis, DNA; D006113:United Kingdom / Q000453:epidemiology
chemical_list: D012367:RNA, Viral
keywords: PCR; cerebrospinal fluid; infants; neonates; parechovirus; sepsis