title: Regional Comparisons of Optical Coherence Tomography Angiography Vessel Density in Primary Open-Angle Glaucoma.
abstract: OBJECTIVE
  To compare the diagnostic abilities of the vessel densities in optic nerve head (ONH), peripapillary, and macular regions measured using optical coherence tomography angiography (OCTA) in eyes with primary open-angle glaucoma (POAG), and to evaluate the effect of glaucoma severity (based on the mean deviation, MD), optic disc size, and pretreatment intraocular pressure (IOP).
  
  
  METHODS
  Cross-sectional study.
  
  
  METHODS
  Seventy-eight eyes of 53 control subjects and 64 eyes of 39 POAG patients underwent OCTA imaging. Area under receiver operating characteristic (ROC) curves (AUC) and sensitivities at fixed specificities of vessel densities in ONH, peripapillary, and macular regions were analyzed. ROC regression was used to evaluate the effect of covariates on the diagnostic abilities.
  
  
  RESULTS
  The AUCs of ONH vessel densities ranged between 0.59 (superonasal sector) and 0.73 (average inside disc), peripapillary between 0.70 (nasal, superonasal and temporal) and 0.89 (inferotemporal), and macular between 0.56 (nasal) and 0.64 (temporal). AUC of the average peripapillary vessel density was significantly better than the average inside disc (P = .05) and macular (P = .005) measurement. MD showed a negative association with the AUCs of the vessel densities of all regions. Pretreatment IOP (coefficient: 0.09) showed a significant (P < .05) effect on the AUC of ONH vessel density.
  
  
  CONCLUSIONS
  Diagnostic ability of the vessel density parameters of OCTA was only moderate. Macular and inside disc densities had significantly lower diagnostic abilities in POAG than the peripapillary density. Diagnostic abilities of vessel densities increased with increasing severity of glaucoma and that of ONH vessel density with higher pretreatment IOPs.
authors: Department of Glaucoma, Narayana Nethralaya, Bangalore, India. Electronic address: harshalaxmanarao@gmail.com.
authors: Harsha L
authors: HL
authors: Rao
authors: Department of Glaucoma, Narayana Nethralaya, Bangalore, India.
authors: Zia S
authors: ZS
authors: Pradhan
authors: Hamilton Glaucoma Center and Department of Ophthalmology, Shiley Eye Institute, University of California, San Diego, La Jolla, California.
authors: Robert N
authors: RN
authors: Weinreb
authors: Department of Glaucoma, Narayana Nethralaya, Bangalore, India.
authors: Hemanth B
authors: HB
authors: Reddy
authors: Department of Glaucoma, Narayana Nethralaya, Bangalore, India.
authors: Mohammed
authors: M
authors: Riyazuddin
authors: Department of Glaucoma, Narayana Nethralaya, Bangalore, India.
authors: Srilakshmi
authors: S
authors: Dasari
authors: Department of Glaucoma, Narayana Nethralaya, Bangalore, India.
authors: Meena
authors: M
authors: Palakurthy
authors: Department of Glaucoma, Narayana Nethralaya, Bangalore, India.
authors: Narendra K
authors: NK
authors: Puttaiah
authors: Department of Glaucoma, Narayana Nethralaya, Bangalore, India.
authors: Dhanaraj A S
authors: DA
authors: Rao
authors: Department of Ophthalmology, University Eye Clinic Maastricht, University Medical Center, Maastricht, Netherlands.
authors: Carroll A B
authors: CA
authors: Webers
mesh_terms: D000368:Aged; D003430:Cross-Sectional Studies; D005260:Female; D005451:Fluorescein Angiography / Q000379:methods*; D005654:Fundus Oculi; D005902:Glaucoma, Open-Angle / Q000175:diagnosis* / Q000503:physiopathology; D006801:Humans; D007429:Intraocular Pressure; D008297:Male; D008875:Middle Aged; D009412:Nerve Fibers / Q000473:pathology; D009898:Optic Disk / Q000098:blood supply*; D012372:ROC Curve; D012165:Retinal Ganglion Cells / Q000473:pathology; D012171:Retinal Vessels / Q000000981:diagnostic imaging*; D012189:Retrospective Studies; D041623:Tomography, Optical Coherence / Q000379:methods*; D014794:Visual Fields