title: Oral Anticoagulation in the Elderly: New Oral Anticoagulants-Innovative Solution for an Old Problem?
abstract: Direct oral anticoagulants emerge as the most innovative and promising drug toward preventing and treating cardiovascular disease, raising great interest among the scientific community. Numerous studies and meta-analysis generated much data clarifying clinicians' doubts; however, uncertainties remain regarding their use in particular groups such as patients with prosthetic valves, in valvular atrial fibrillation (defined as atrial fibrillation related to mitral rheumatic heart disease or prosthetic heart valves), among the elderly, in paraneoplastic thromboembolism, in pulmonary embolism with hemodynamic compromise, and scarcity of specific antidotes. This review article intends to condense the vast scientific production addressing new oral anticoagulants by focusing on their advantages and disadvantages when used on the elderly.
authors: Emergency Department, Vila Franca de Xira Hospital and Internal Medicine Department of the CUF Torres Vedras Hospital, Torres Vedras, Portugal.
authors: Mario
authors: M
authors: Barbosa
authors: Department of Internal Medicine, Santa Maria Hospital, Lisbon University of Medicine, Lisboa, Portugal.
authors: Luiz
authors: L
authors: Menezes Falcão
mesh_terms: D000284:Administration, Oral; D000367:Age Factors; D000368:Aged; D000375:Aging / Q000502:physiology; D000925:Anticoagulants / Q000494:pharmacology* / Q000627:therapeutic use; D000933:Antifibrinolytic Agents / Q000627:therapeutic use*; D001777:Blood Coagulation / Q000187:drug effects* / Q000502:physiology; D002318:Cardiovascular Diseases / Q000188:drug therapy* / Q000517:prevention & control; D004347:Drug Interactions; D057915:Drug Substitution / Q000009:adverse effects / Q000379:methods; D006470:Hemorrhage / Q000139:chemically induced / Q000188:drug therapy / Q000453:epidemiology*; D006801:Humans
chemical_list: D000925:Anticoagulants; D000933:Antifibrinolytic Agents