title: Lipid Accumulation Product (LAP) and Visceral Adiposity Index (VAI) as Markers of Insulin Resistance and Metabolic Associated Disturbances in Young Argentine Women with Polycystic Ovary Syndrome.
abstract: Polycystic ovary syndrome (PCOS) is an endocrine disorder. PCOS women are at high risk of developing insulin resistance (IR) and cardiovascular disorders since young age. We aimed to study the reliability of lipid accumulation product (LAP) and visceral adiposity index (VAI) as markers of metabolic disturbances (MD) associated with IR in young reproductive aged PCOS patients. We also evaluated the association between LAP and VAI and the presence of hyperandrogenism. In a cross-sectional study, 110 PCOS patients and 88 control women (18-35 years old) were recruited. PCOS patients were divided into 2 groups, as hyperandrogenic and non-hyperandrogenic considering the signs of hyperandrogenism (clinical or biochemical). Anthropometric measurements were taken and blood samples collected. Metabolic and anthropometric characteristics and their association with IR and associated MD were evaluated and LAP and VAI were calculated. LAP and VAI were compared with TC/HDL-c and TG/HDL-c to define the best markers of MD in this population. Independently of the phenotype, young PCOS patients showed high IR and dyslipidemia. Both LAP and VAI showed to be more effective markers to assess MD and IR in these young women than TG/HDL-c or TC/HDL-c [cut-off values: LAP: 18.24 (sensitivity: 81.43% specificity: 73.49%), positive predictive value (PPV): 75.0%, negative predictive value (NPV): 77.27%, VAI: 2.19 (sensitivity: 81.16% specificity: 72.15% PPV: 74.65% NPV: 72.22%)]. LAP and VAI are representative markers to assess MD associated with IR in young PCOS patients. All PCOS patients, independently of their androgenic condition, showed high metabolic risk.
authors: Laboratorio de Fisio-patología Ovárica, Centro de Estudios Farmacológicos y Botánicos (CEFYBO), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Facultad de Medicina, Universidad de Buenos Aires (UBA), Buenos Aires, Argentina.
authors: Giselle A
authors: GA
authors: Abruzzese
authors: Cátedra de Genética, Departamento de Microbiología, Inmunología y Biotecnología, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires e Instituto de Inmunología, Genética y Metabolismo (CONICET-UBA). Buenos Aires, Argentina.
authors: Gloria E
authors: GE
authors: Cerrrone
authors: División de Endocrinología, Hospital General de Agudos Carlos G Durand, Buenos Aires, Argentina.
authors: Juan M
authors: JM
authors: Gamez
authors: División de Endocrinología, Hospital General de Agudos Carlos G Durand, Buenos Aires, Argentina.
authors: Mabel N
authors: MN
authors: Graffigna
authors: División de Endocrinología, Hospital General de Agudos Carlos G Durand, Buenos Aires, Argentina.
authors: Susana
authors: S
authors: Belli
authors: División Ginecología, Hospital Nacional Profesor Alejandro Posadas, Provincia de Buenos Aires, Argentina.
authors: Gustavo
authors: G
authors: Lioy
authors: División de Endocrinología, Hospital General de Agudos Carlos G Durand, Buenos Aires, Argentina.
authors: Eduardo
authors: E
authors: Mormandi
authors: División de Endocrinología, Hospital General de Agudos Carlos G Durand, Buenos Aires, Argentina.
authors: Patricia
authors: P
authors: Otero
authors: División de Endocrinología, Hospital General de Agudos Carlos G Durand, Buenos Aires, Argentina.
authors: Oscar A
authors: OA
authors: Levalle
authors: Laboratorio de Fisio-patología Ovárica, Centro de Estudios Farmacológicos y Botánicos (CEFYBO), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Facultad de Medicina, Universidad de Buenos Aires (UBA), Buenos Aires, Argentina.
authors: Alicia B
authors: AB
authors: Motta
mesh_terms: D050154:Adiposity / Q000502:physiology; D000293:Adolescent; D000328:Adult; D001118:Argentina; D015415:Biomarkers / Q000378:metabolism; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D007333:Insulin Resistance; D050152:Intra-Abdominal Fat / Q000473:pathology*; D064237:Lipid Accumulation Product; D008659:Metabolic Diseases / Q000150:complications* / Q000175:diagnosis / Q000209:etiology / Q000473:pathology; D056128:Obesity, Abdominal / Q000150:complications / Q000175:diagnosis / Q000378:metabolism / Q000473:pathology; D011085:Polycystic Ovary Syndrome / Q000150:complications* / Q000175:diagnosis / Q000378:metabolism / Q000473:pathology; D011237:Predictive Value of Tests; D015203:Reproducibility of Results; D064346:Sagittal Abdominal Diameter; D055815:Young Adult
chemical_list: D015415:Biomarkers