title: Prognostic value of metabolic parameters on preoperative 18F-fluorodeoxyglucose positron emission tomography/ computed tomography in patients with stage III gastric cancer.
abstract: This study investigated the prognostic value of metabolic parameters determined by 18F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) in patients with stage III gastric cancer. Patients with pre-operative PET/CT and confirmed stage III after curative surgical resection were retrospectively enrolled. Parameters evaluated from pre-operative PET/CTwere maximum standardized uptake value (SUVmax) and peak SUV (SUVpeak) of primary tumor, SUVmax or SUVpeak of tumor to liver ratio (TLRmax and TLRpeak). Volumetric parameters, metabolic tumor volume (MTV) and total lesion glycolysis (TLG), were also evaluated. These PET/CT parameters were compared with the overall survival (OS) and recurrence-free survival (RFS). From total of 133 consecutive patients, tumor recurrence was found in 54 patients (40.6%) and 53 died during the follow-up period (median, 43 mo; range 5-62). In univariate analysis, SUVmax, SUVpeak, TLRmax and TLRpeak were significantly associated with the OS and RFS. In multivariate analysis, high TLRmax and TLRpeak were significantly unfavorable prognostic factors for RFS (both P<0.05) even after adjusting for age, depth of tumor invasion, lymph node metastasis, and chemotherapy. MTV and TLG showed no statistically significant correlation with outcome. In conclusion, glucose metabolism of primary tumor measured by pre-operative PET/CT provides prognostic information, especially for recurrence, in stage III gastric cancer.
authors: Department of Radiology, The Catholic University of Korea, Uijeongbu St. Mary's Hospital, Seoul, Korea.
authors: Sae Jung
authors: SJ
authors: Na
authors: Department of Radiology, The Catholic University of Korea, Seoul St. Mary's Hospital, Seoul, Korea.
authors: Joo Hyun
authors: JH
authors: o
authors: Department of Internal Medicine, The Catholic University of Korea, Seoul St. Mary's Hospital, Seoul, Korea.
authors: Jae Myung
authors: JM
authors: Park
authors: Department of Radiology, The Catholic University of Korea, Seoul St. Mary's Hospital, Seoul, Korea.
authors: Han Hee
authors: HH
authors: Lee
authors: Department of Hospital Pathology, The Catholic University of Korea, Seoul St. Mary's Hospital, Seoul, Korea.
authors: Sung Hak
authors: SH
authors: Lee
authors: Department of Surgery, The Catholic University of Korea, Seoul St. Mary's Hospital, Seoul, Korea.
authors: Kyo Young
authors: KY
authors: Song
authors: Department of Radiology, The Catholic University of Korea, Seoul St. Mary's Hospital, Seoul, Korea.
authors: Myung-Gyu
authors: MG
authors: Choi
authors: Department of Surgery, The Catholic University of Korea, Seoul St. Mary's Hospital, Seoul, Korea.
authors: Cho Hyun
authors: CH
authors: Park
mesh_terms: D000328:Adult; D000368:Aged; D018572:Disease-Free Survival; D005260:Female; D019788:Fluorodeoxyglucose F18; D005500:Follow-Up Studies; D006019:Glycolysis; D006801:Humans; D008099:Liver / Q000473:pathology; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009364:Neoplasm Recurrence, Local; D000072078:Positron Emission Tomography Computed Tomography; D011379:Prognosis; D019275:Radiopharmaceuticals; D012189:Retrospective Studies; D013274:Stomach Neoplasms / Q000000981:diagnostic imaging*; D016896:Treatment Outcome
chemical_list: D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18
keywords: gastric cancer; positron emission tomography; prognosis; tumor metabolism