title: Circulating interleukin-6 is not altered while γ-tocopherol is increased in subjects scheduled for knee surgery with low vitamin D.
abstract: The purpose of this study was to identify if circulating interleukin (IL)-6 and γ-tocopherol (γT) fluctuate with vitamin D status in subjects with an underlying knee joint injury or disease. We hypothesized that low vitamin D associates with an increase in plasma γT while serum IL-6 remains unchanged in subjects with an underlying knee joint trauma or disease. Fifty-four subjects scheduled to undergo primary, unilateral anterior cruciate ligament reconstructive surgery (ACL; n=27) or total knee arthroplasty (TKA; n=27) were studied. Circulating γT, α-tocopherol (αT), lipids (cholesterol and triglycerides), IL-6, and 25-hydroxyvitamin D (25(OH)D) were measured in fasting blood samples obtained prior to surgery. Subjects were classified as vitamin D deficient, insufficient, or sufficient if they had a serum 25(OH)D concentration <50, 50-75, or >75nM, respectively. The majority (57%) of the subjects possessed a serum 25(OH)D less than 50nM. Circulating cholesterol, triglycerides, and IL-6 were not significantly (all p>0.05) different between vitamin D status groups. However, lipid corrected αT was significantly (p<0.05) decreased and both lipid- and non-lipid-corrected plasma γT concentrations were significantly (both p<0.05) increased with low serum 25(OH)D (i.e., <50nM). A significant (p<0.05) multi-variate analysis revealed that an increase in plasma γT per lipids was significantly (p<0.05) predicted by a decrease in serum 25(OH)D but not by a decrease in plasma αT per lipids. We conclude that low vitamin D associates with an increase in plasma γT but not IL-6 in subjects with an underlying joint injury or disease.
authors: The Orthopedic Specialty Hospital, Murray, UT 84107, USA. Electronic address: tyler.barker@imail.org.
authors: Tyler
authors: T
authors: Barker
authors: The Orthopedic Specialty Hospital, Murray, UT 84107, USA.
authors: Vanessa T
authors: VT
authors: Henriksen
authors: The Orthopedic Specialty Hospital, Murray, UT 84107, USA.
authors: Victoria E
authors: VE
authors: Rogers
authors: The Orthopedic Specialty Hospital, Murray, UT 84107, USA; The Orthopedic Specialty Clinic, Murray, UT 84107, USA.
authors: Nathan G
authors: NG
authors: Momberger
authors: The Orthopedic Specialty Hospital, Murray, UT 84107, USA; The Orthopedic Specialty Clinic, Murray, UT 84107, USA.
authors: G Lynn
authors: GL
authors: Rasmussen
authors: The Orthopedic Specialty Hospital, Murray, UT 84107, USA; The Orthopedic Specialty Clinic, Murray, UT 84107, USA.
authors: Roy H
authors: RH
authors: Trawick
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D015850:Interleukin-6 / Q000097:blood*; D007718:Knee Injuries / Q000097:blood* / Q000601:surgery*; D007719:Knee Joint / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D014808:Vitamin D Deficiency / Q000097:blood* / Q000601:surgery; D024504:gamma-Tocopherol / Q000097:blood*
chemical_list: C508600:IL6 protein, human; D015850:Interleukin-6; D024504:gamma-Tocopherol
keywords: Interleukin-6; Orthopedics; Vitamin D; Vitamin E