title: Early predictive factors for lower-extremity motor or sensory deficits and surgical results of patients with spinal tuberculosis: A retrospective study of 329 patients.
abstract: Many studies about the characteristics of spinal tuberculosis (STB) have been published, but none has investigated the predictive factors for lower-extremity motor or sensory deficits (LMSD) in patients with STB.The objective of this study was to find early predictive factors for LMSD and evaluate surgical results of patients with STB.From 2001 through 2010, 329 patients with STB were treated in our department and surgical treatment was performed in 274 patients. The factors assessed included age, sex, duration of symptoms, worsening of illness, clinical symptoms, clinical signs, imaging characteristics, kyphotic angle, Oswestry disability index (ODI), and visual analogue scale (VAS) scores.Of the 329 patients studied, 164 presented with LMSD (the LMSD group), of which 93 patients (28.3%) had motor deficits and 177 patients (53.8%) had sensory disturbance. The other 165 patients were included in the control group (the No LMSD group). Using univariate logistic regression analysis, we found that the sex (P = 0.042), age (P = 0.001), worsening of sickness (P = 0.013), location (P = 0.009), and spinal compression (P = 0.035) were the risk factors of LMSD. Furthermore, the multivariate logistic regression analysis indicated that age (OR = 1.761, 95% CI: 1.227-2.526, P = 0.002), worsening of sickness (yes vs no: OR = 1.910, 95% CI: 1.161-3.141, P = 0.011), location (T vs C: OR = 0.204, 95% CI: 0.063-0.662, P = 0.008), and spinal compression (yes vs no: OR = 1.672, 95% CI: 1.020-2.741, P = 0.042) were independent risk factors of LMSD. Surgical treatment was performed in 274 patients. The kyphotic angle improved from 25.8 ± 9.1° preoperatively to 14.0 ± 7.6°, with a mean correction of 11.8 ± 4.0°, and a mean correction loss of 1.5 ± 1.8° at final visit. There were significant differences between the preoperative and the final ODI and VAS scores in both groups (P < 0.001 and P < 0.001, respectively).Spinal tuberculosis with cervical or lumbar vertebra involvement among the elder patients with a history of worsening of illness and spinal compression tended to cause LMSD, such as motor deficits or sensory disturbance. We should implement an appropriate treatment regimen to prevent exacerbation of STB such as operation, which can achieve thoroughness of debridement, adequate spinal stabilization, and better functional recovery.
authors: Department of Orthopedics, General Hospital of Shenyang Military Area Command of Chinese PLA Department of Nursing, People's Liberation Army 463rd Hospital, Shenyang, Liaoning Department of Orthopedics, Xinqiao Hospital, The Third Military Medical University, Chongqing Department of Orthopedics, People's Liberation Army 113th Hospital, Ningbo, Zhejiang State Key Laboratory of Robotics, Shenyang Institute of Automation, Chinese Academy of Science, Shenyang, Liaoning, China.
authors: Hongwei
authors: H
authors: Wang
authors: Xiao
authors: X
authors: Yang
authors: Ying
authors: Y
authors: Shi
authors: Yue
authors: Y
authors: Zhou
authors: Changqing
authors: C
authors: Li
authors: Yu
authors: Y
authors: Chen
authors: Hailong
authors: H
authors: Yu
authors: Qi
authors: Q
authors: Wang
authors: Jun
authors: J
authors: Liu
authors: Jiwei
authors: J
authors: Cheng
authors: Yiwen
authors: Y
authors: Zhao
authors: Jianda
authors: J
authors: Han
authors: Liangbi
authors: L
authors: Xiang
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D002574:Cervical Vertebrae; D002648:Child; D002675:Child, Preschool; D004185:Disability Evaluation; D005260:Female; D006801:Humans; D035002:Lower Extremity; D008159:Lumbar Vertebrae; D008297:Male; D008875:Middle Aged; D000068079:Motor Disorders / Q000382:microbiology*; D010523:Peripheral Nervous System Diseases / Q000382:microbiology*; D012189:Retrospective Studies; D012307:Risk Factors; D012678:Sensation Disorders / Q000382:microbiology*; D012720:Severity of Illness Index; D013117:Spinal Cord Compression / Q000382:microbiology*; D013904:Thoracic Vertebrae; D014399:Tuberculosis, Spinal / Q000150:complications* / Q000601:surgery*; D055815:Young Adult