title: Clinicopathological, functional, and immediate oncologic outcome assessment in men aged≤50 years with prostate cancer after robotic prostatectomy.
abstract: To define the pathologic and functional outcomes of men 50 years of age and younger with prostate cancer in a contemporary robotic cohort, this study was designed.
  
  
  
  Patients undergoing robotic-assisted laparoscopic prostatectomy from April 2002 to April 2012 (n = 2,495) formed the base population for the current analyses. The patients were dichotomized according to their age≤50 (n = 271) and>50-year-old (n = 2,224). Clinicopathological and health-related quality-of-life outcomes were recorded and analyzed for differences. Propensity score matching was used when assessing urinary and sexual function outcome.
  
  
  
  Baseline prostate-specific antigen and clinical stage were similar between men older than 50 years and those younger. Younger patients had less severe disease (D׳Amico risk and Gleason scores) and smaller prostates. Young men had higher rates of erectile function at all time points, including baseline (94% vs. 83% at 12mo, P <0.01). Continence was similar at all time points except for 6 months, where younger patients experienced a faster return than older patients and then remained constant, while older patients continued to improve (96% vs. 89%, P<0.01). After matching process, the difference in erectile function at 6-month follow-up was lost.
  
  
  
  Most men aged 50 years and younger who received robotic-assisted laparoscopic prostatectomy had clinically significant prostate cancer. Although histopathologic and short-term oncologic outcomes were nearly identical when compared to older patients, younger men had a more rapid and superior return of erectile function.
authors: Department of Urology, Northwell Lenox Hill Hospital, New York, NY. Electronic address: robotmd@yahoo.com.
authors: David B
authors: DB
authors: Samadi
authors: Department of Urology, Mount Sinai Medical Center, New York, NY.
authors: Dov
authors: D
authors: Sebrow
authors: Department of Urology, Mount Sinai Medical Center, New York, NY.
authors: Adele R
authors: AR
authors: Hobbs
authors: Department of Urology, Mount Sinai Medical Center, New York, NY.
authors: Adrien N
authors: AN
authors: Bernstein
authors: Department of Urology, Mount Sinai Medical Center, New York, NY.
authors: Jonathan
authors: J
authors: Brajtbord
authors: Department of Urology, Mount Sinai Medical Center, New York, NY.
authors: Hugh J
authors: HJ
authors: Lavery
authors: Department of Urology, Northwell Lenox Hill Hospital, New York, NY.
authors: Seyed Behzad
authors: SB
authors: Jazayeri
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D007172:Erectile Dysfunction / Q000209:etiology*; D006801:Humans; D010535:Laparoscopy / Q000009:adverse effects; D008297:Male; D008875:Middle Aged; D060787:Neoplasm Grading; D010410:Penile Erection; D011184:Postoperative Period; D057216:Propensity Score; D011468:Prostatectomy / Q000009:adverse effects*; D011471:Prostatic Neoplasms / Q000473:pathology / Q000503:physiopathology / Q000601:surgery*; D011788:Quality of Life; D020127:Recovery of Function; D065287:Robotic Surgical Procedures / Q000009:adverse effects; D013997:Time Factors; D014549:Urinary Incontinence / Q000209:etiology*
keywords: Erectile function; Prostate cancer; Robotic prostatectomy; Urine continence; Young