title: Effect of drug physicochemical properties on drug release and their relationship with drug skin permeation behaviors in hydroxyl pressure sensitive adhesive.
abstract: The aim of this study was to investigate the influence of drug physicochemical properties on drug release behaviors and their relationship with skin permeation behaviors, which provided transdermal enhancement strategies for the design of transdermal drug delivery system. Six model drugs with different physicochemical properties were selected and hydroxyl pressure sensitive adhesive (PSA) was synthesized. Horizontal diffusion cell was used to evaluate drug release and skin permeation behaviors. The relationship between physicochemical properties and release behaviors was conducted with regression analysis. Release behavior of 0.25% drug loading was linear related with polar surface area, which represented the hydrogen bond. Release behavior of 2.0% drug loading was dependent on the polarizability and log P, which represented dipole-dipole interaction and lipophilicity, respectively. According to the results of Fourier transform infrared spectroscopy, it was inferred that hydrogen bond was limited in controlling release of drug due to the limited quantity of bonding site, thus dipole-dipole interaction and log P became dominate control factors. Combining the drug release study and drug skin permeation study, it was concluded that drugs with different physicochemical properties should be applied with different transdermal enhancement strategies, which was useful for the design of transdermal drug delivery system.
authors: Department of Pharmaceutical Sciences, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang, Liaoning 110016, China.
authors: Chao
authors: C
authors: Liu
authors: Department of Pharmaceutical Sciences, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang, Liaoning 110016, China.
authors: Peng
authors: P
authors: Quan
authors: Department of Pharmaceutical Sciences, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang, Liaoning 110016, China. Electronic address: fangliang2003@yahoo.com.
authors: Liang
authors: L
authors: Fang
mesh_terms: D000269:Adhesives / Q000737:chemistry* / Q000378:metabolism; D000818:Animals; D004058:Diffusion; D016503:Drug Delivery Systems; D065546:Drug Liberation; D017665:Hydroxyl Radical; D066298:In Vitro Techniques; D004364:Pharmaceutical Preparations / Q000737:chemistry* / Q000378:metabolism; D011312:Pressure; D017208:Rats, Wistar; D012867:Skin / Q000378:metabolism; D012869:Skin Absorption
chemical_list: D000269:Adhesives; D004364:Pharmaceutical Preparations; D017665:Hydroxyl Radical
keywords: Drug release; Hydroxyl pressure sensitive adhesive; Physicochemical parameter; Polar surface area; Polarizability; Transdermal; log P