title: Effects of BPA on female reproductive function: The involvement of epigenetic mechanism.
abstract: Epigenetic modifications are classified as heritable and reversible chemical modifications of chromatin that do not cause changes in DNA sequence. Changes in epigenetic modifications can be caused by exposure to certain environmental factors, such as contaminants like bisphenol A (BPA). Bisphenol A is ubiquitous in the environment and produced in large quantities, and known to have hormone-like activity, whereby disrupting endocrine function. Because of evidence for disruption of sex steroid mediated pathways, there is a concern that BPA could have adverse effects on female reproduction. The purpose of this review is to summarize the effects of BPA on adult female reproduction with focus on epigenetic changes that can be heritable.
authors: Dipartimento Scienze della Vita e dell'Ambiente, Università Politecnica delle Marche, Via Brecce Bianche, 60131 Ancona, Italy; INBB Consorzio Interuniversitario di Biosistemi e Biostrutture, 00136 Roma, Italy.
authors: Stefania
authors: S
authors: Santangeli
authors: Dipartimento Scienze della Vita e dell'Ambiente, Università Politecnica delle Marche, Via Brecce Bianche, 60131 Ancona, Italy; INBB Consorzio Interuniversitario di Biosistemi e Biostrutture, 00136 Roma, Italy.
authors: Francesca
authors: F
authors: Maradonna
authors: Dipartimento Scienze della Vita e dell'Ambiente, Università Politecnica delle Marche, Via Brecce Bianche, 60131 Ancona, Italy.
authors: Ike
authors: I
authors: Olivotto
authors: Dipartimento Scienze della Vita e dell'Ambiente, Università Politecnica delle Marche, Via Brecce Bianche, 60131 Ancona, Italy.
authors: Chiara Carla
authors: CC
authors: Piccinetti
authors: Dipartimento Scienze della Vita e dell'Ambiente, Università Politecnica delle Marche, Via Brecce Bianche, 60131 Ancona, Italy.
authors: Giorgia
authors: G
authors: Gioacchini
authors: Dipartimento Scienze della Vita e dell'Ambiente, Università Politecnica delle Marche, Via Brecce Bianche, 60131 Ancona, Italy; INBB Consorzio Interuniversitario di Biosistemi e Biostrutture, 00136 Roma, Italy. Electronic address: o.carnevali@univpm.it.
authors: Oliana
authors: O
authors: Carnevali
mesh_terms: D000818:Animals; D001559:Benzhydryl Compounds / Q000633:toxicity*; D052244:Endocrine Disruptors / Q000633:toxicity*; D004785:Environmental Pollutants / Q000633:toxicity*; D044127:Epigenesis, Genetic / Q000187:drug effects*; D005260:Female; D010636:Phenols / Q000633:toxicity*; D012098:Reproduction / Q000187:drug effects; D000098826:Bisphenol A Compounds
chemical_list: D001559:Benzhydryl Compounds; D052244:Endocrine Disruptors; D004785:Environmental Pollutants; D010636:Phenols; C006780:bisphenol A; D000098826:Bisphenol A Compounds
keywords: DNA methylation; Endocrine disruptors; Environmental toxins; Epigenetic; Female fertility; Histone modifications; Reproduction