title: GOLM1 Modulates EGFR/RTK Cell-Surface Recycling to Drive Hepatocellular Carcinoma Metastasis.
abstract: The mechanism of cancer metastasis remains poorly understood. Using gene profiling of hepatocellular carcinoma (HCC) tissues, we have identified GOLM1 as a leading gene relating to HCC metastasis. GOLM1 expression is correlated with early recurrence, metastasis, and poor survival of HCC patients. Both gain- and loss-of-function studies determine that GOLM1 acts as a key oncogene by promoting HCC growth and metastasis. It selectively interacts with epidermal growth factor receptor (EGFR) and serves as a specific cargo adaptor to assist EGFR/RTK anchoring on the trans-Golgi network (TGN) and recycling back to the plasma membrane, leading to prolonged activation of the downstream kinases. These findings reveal the functional role of GOLM1, a Golgi-related protein, in EGFR/RTK recycling and metastatic progression of HCC.
authors: Liver Cancer Institute, Fudan University, Shanghai 200032, China.
authors: Qing-Hai
authors: QH
authors: Ye
authors: Liver Cancer Institute, Fudan University, Shanghai 200032, China; Department of General Surgery, Huashan Hospital, Cancer Metastasis Institute, Fudan University, 12 Urumqi Road (M), Shanghai 200040, China.
authors: Wen-Wei
authors: WW
authors: Zhu
authors: Liver Cancer Institute, Fudan University, Shanghai 200032, China; Department of Infectious Diseases, Huashan Hospital, Fudan University, Shanghai 200040, China.
authors: Ju-Bo
authors: JB
authors: Zhang
authors: Institutes of Biomedical Science, Fudan University, Shanghai 200032, China; Department of Pancreatic and Hepatobiliary Surgery, Fudan University Shanghai Cancer Center, Shanghai 200032, China.
authors: Yi
authors: Y
authors: Qin
authors: Department of General Surgery, Huashan Hospital, Cancer Metastasis Institute, Fudan University, 12 Urumqi Road (M), Shanghai 200040, China.
authors: Ming
authors: M
authors: Lu
authors: Liver Cancer Institute, Fudan University, Shanghai 200032, China.
authors: Guo-Ling
authors: GL
authors: Lin
authors: Liver Cancer Institute, Fudan University, Shanghai 200032, China.
authors: Lei
authors: L
authors: Guo
authors: Liver Cancer Institute, Fudan University, Shanghai 200032, China.
authors: Bo
authors: B
authors: Zhang
authors: Liver Cancer Institute, Fudan University, Shanghai 200032, China.
authors: Zhen-Hai
authors: ZH
authors: Lin
authors: Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA; Institute of Pathology, University Hospital Heidelberg 69120 Heidelberg, Germany.
authors: Stephanie
authors: S
authors: Roessler
authors: Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA.
authors: Marshonna
authors: M
authors: Forgues
authors: Department of General Surgery, Huashan Hospital, Cancer Metastasis Institute, Fudan University, 12 Urumqi Road (M), Shanghai 200040, China.
authors: Hu-Liang
authors: HL
authors: Jia
authors: Department of General Surgery, Huashan Hospital, Cancer Metastasis Institute, Fudan University, 12 Urumqi Road (M), Shanghai 200040, China.
authors: Lu
authors: L
authors: Lu
authors: Department of General Surgery, Huashan Hospital, Cancer Metastasis Institute, Fudan University, 12 Urumqi Road (M), Shanghai 200040, China.
authors: Xiao-Fei
authors: XF
authors: Zhang
authors: Shanghai Center for Bioinformatics Technology, Shanghai 201203, China.
authors: Bao-Feng
authors: BF
authors: Lian
authors: Shanghai Center for Bioinformatics Technology, Shanghai 201203, China.
authors: Lu
authors: L
authors: Xie
authors: Department of General Surgery, Huashan Hospital, Cancer Metastasis Institute, Fudan University, 12 Urumqi Road (M), Shanghai 200040, China; Institutes of Biomedical Science, Fudan University, Shanghai 200032, China.
authors: Qiong-Zhu
authors: QZ
authors: Dong
authors: Liver Cancer Institute, Fudan University, Shanghai 200032, China; Department of General Surgery, Huashan Hospital, Cancer Metastasis Institute, Fudan University, 12 Urumqi Road (M), Shanghai 200040, China.
authors: Zhao-You
authors: ZY
authors: Tang
authors: Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA. Electronic address: xw3u@nih.gov.
authors: Xin Wei
authors: XW
authors: Wang
authors: Liver Cancer Institute, Fudan University, Shanghai 200032, China; Department of General Surgery, Huashan Hospital, Cancer Metastasis Institute, Fudan University, 12 Urumqi Road (M), Shanghai 200040, China; Institutes of Biomedical Science, Fudan University, Shanghai 200032, China. Electronic address: qinlx@fudan.edu.cn.
authors: Lun-Xiu
authors: LX
authors: Qin
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000818:Animals; D006528:Carcinoma, Hepatocellular / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D045744:Cell Line, Tumor; D066246:ErbB Receptors / Q000235:genetics / Q000378:metabolism*; D064593:Heterografts; D006801:Humans; D008113:Liver Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D008297:Male; D008565:Membrane Proteins / Q000096:biosynthesis / Q000235:genetics / Q000378:metabolism*; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D008875:Middle Aged; D009362:Neoplasm Metastasis; D014162:Transfection; D015854:Up-Regulation; D055815:Young Adult
chemical_list: C410824:GOLM1 protein, human; D008565:Membrane Proteins; C512478:EGFR protein, human; D066246:ErbB Receptors