title: Prognostic Significance of Blood Type A in Patients with Renal Cell Carcinoma.
abstract: OBJECTIVE
  In this study, we evaluated the prognostic significance of the ABO blood type in patients with renal cell carcinoma (RCC) who had undergone partial or radical nephrectomy.
  
  
  METHODS
  Information on the ABO blood type was obtained from 1750 patients with RCC. A total of 1243 men and 507 women (mean age, 55.41 &plusmn; 12.43 years) with RCC who had undergone partial or radical nephrectomy were enrolled in this study. The median follow-up duration was 35.0 months (interquartile range [IQR], 16.0-67.0). During the follow-up period, 271 patients experienced RCC recurrence, and 137 patients died from RCC.
  
  
  RESULTS
  Type A was the most common blood type (568, 32.5%), followed by type O (525, 30.0%), type B (464, 26.5%), and type AB (193, 11.0%). Generally, blood type was not associated with any clinicopathological factors. Unlike blood type O, the multivariate analysis of progression-free survival (PFS) showed that blood type non-O (A, B, and AB) was an independent prognostic factor for a worse outcome (95% confidence interval [CI]: 1.24- 2.37, hazard ratio [HR] = 1.71, P = .001; 95% CI: 1.08-2.13, HR = 1.51, P = .016; 95% CI: 1.03-2.43, HR = 1.58, P = .037, respectively). Cancer-specific survival (CSS) analysis showed that blood type A was an independent factor associated with a worse prognosis for CSS (95% CI: 1.05-2.64, HR 1.66, P = .031, respectively).
  
  
  CONCLUSIONS
  The ABO blood type is significantly associated with PFS and CSS in patients with RCC following partial or radical nephrectomy. Blood type non-O (A, B, and AB) is an independent prognostic factor for a worse PFS outcome, and blood type A is an independent factor associated with a worse CSS prognosis.&nbsp.
authors: Department of Urology, Hallym University College of Medicine, Seoul, Korea. palindromes@hanmail.net.
authors: Kyungtae
authors: K
authors: Ko
authors: Department of Urology, Seoul National University College of Medicine, Seoul, Korea.
authors: Young Hyun
authors: YH
authors: Park
authors: Department of Urology, Seoul National University College of Medicine, Seoul, Korea.
authors: Chang Wook
authors: CW
authors: Jeong
authors: Department of Urology, Seoul National University College of Medicine, Seoul, Korea.
authors: Ja Hyeon
authors: JH
authors: Ku
authors: Department of Urology, Seoul National University College of Medicine, Seoul, Korea.
authors: Hyeon Hoe
authors: HH
authors: Kim
authors: Department of Urology, Seoul National University College of Medicine, Seoul, Korea.
authors: Cheol
authors: C
authors: Kwak
mesh_terms: D000017:ABO Blood-Group System; D000368:Aged; D002292:Carcinoma, Renal Cell / Q000097:blood* / Q000401:mortality* / Q000601:surgery; D003430:Cross-Sectional Studies; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D007680:Kidney Neoplasms / Q000097:blood* / Q000401:mortality* / Q000601:surgery; D008297:Male; D008875:Middle Aged; D009392:Nephrectomy; D011379:Prognosis; D012189:Retrospective Studies; D015996:Survival Rate
chemical_list: D000017:ABO Blood-Group System