title: High-fat, high-sugar, and high-cholesterol consumption does not impact tau pathogenesis in a mouse model of Alzheimer's disease-like tau pathology.
abstract: Aggregates of hyperphosphorylated tau protein are a pathological hallmark of Alzheimer's disease (AD). The origin of AD is multifactorial, and many metabolic disorders originating from overconsumption of fat, cholesterol, and sugar are associated with higher risk of AD later in life. However, the effects of fat, cholesterol, and sugar overconsumption on tau pathology in AD remain controversial. Using the hTau mice, a model of AD-like tau pathology, we assessed the effects of high-fat, high-cholesterol, and/or high-sugar diets on tau pathogenesis. Surprisingly, we found no effects of these compounds, even combined, on tau phosphorylation, O-GlcNAcylation, splicing, cleavage, and aggregation, suggesting that their overconsumption does not seem to worsen tau pathology in these mice.
authors: Université Laval, Faculté de médecine, Département de Psychiatrie et Neurosciences, Québec, Quebec, Canada; Centre de Recherche du CHU de Québec, Axe Neurosciences, Québec, Quebec, Canada.
authors: Maud
authors: M
authors: Gratuze
authors: Centre de Recherche du CHU de Québec, Axe Neurosciences, Québec, Quebec, Canada.
authors: Jacinthe
authors: J
authors: Julien
authors: Centre de Recherche du CHU de Québec, Axe Neurosciences, Québec, Quebec, Canada.
authors: Françoise
authors: F
authors: Morin
authors: Centre de Recherche du CHU de Québec, Axe Neurosciences, Québec, Quebec, Canada; Université Laval, Faculté de pharmacie, Québec, Quebec, Canada.
authors: Frédéric
authors: F
authors: Calon
authors: Université Laval, Faculté de médecine, Département de Psychiatrie et Neurosciences, Québec, Quebec, Canada; Centre de Recherche du CHU de Québec, Axe Neurosciences, Québec, Quebec, Canada.
authors: Sébastien S
authors: SS
authors: Hébert
authors: Centre de Recherche de l'Institut Universitaire de Cardiologie et de Pneumologie de Québec, Quebec City, Quebec, Canada.
authors: André
authors: A
authors: Marette
authors: Université Laval, Faculté de médecine, Département de Psychiatrie et Neurosciences, Québec, Quebec, Canada; Centre de Recherche du CHU de Québec, Axe Neurosciences, Québec, Quebec, Canada. Electronic address: emmanuel@planel.org.
authors: Emmanuel
authors: E
authors: Planel
mesh_terms: D000544:Alzheimer Disease / Q000209:etiology* / Q000378:metabolism*; D000818:Animals; D002791:Cholesterol, Dietary / Q000008:administration & dosage*; D004041:Dietary Fats / Q000008:administration & dosage*; D019422:Dietary Sucrose / Q000008:administration & dosage*; D004195:Disease Models, Animal; D051379:Mice; D010766:Phosphorylation; D024801:Tauopathies / Q000209:etiology* / Q000378:metabolism*; D016875:tau Proteins / Q000378:metabolism*
chemical_list: D002791:Cholesterol, Dietary; D004041:Dietary Fats; D019422:Dietary Sucrose; D016875:tau Proteins
keywords: Alzheimer's disease; Diabetes; High-cholesterol diet; High-fat diet; High-sugar diet; Obesity; Tau protein; Tauopathy; Western diet