title: Potential of IL-33 for Preventing the Kidney Injury via Regulating the Lipid Metabolism in Gout Patients.
abstract: Interleukin-33 (IL-33), the most recently discovered member of the IL-1 superfamily, has been linked to several human pathologies including autoimmune diseases, sepsis, and allergy through its specific IL-1 receptor ST2. However, there is little information regarding the role of IL-33 in gout. In this study, we investigated the potential role of IL-33 in gout patients. The serum level of IL-33 was measured by ELISA, and the clinical and laboratory parameters, serum creatinine, urea, and lipid, were extracted from medical record system. The serum IL-33 expression was predominantly increased in gout patients compared to healthy controls, and the IL-33 levels were higher in patients without kidney injury. Furthermore, IL-33 showed a negative correlation with biomarkers of kidney injury, such as CRE and urea. The lipid metabolism dysfunction, tophi, and hypertension are the common reasons for kidney injury in gout. Interestingly, inverse and positive correlation of IL-33 expression was observed in LDL and HDL, respectively. However, there was no significant alteration in the gout patients with hypertension and tophi. These data suggested that IL-33 might act as a protective role in kidney injury through regulating the lipid metabolism in gout.
authors: Department of Rheumatology and Clinical Immunology, The First Hospital of Xiamen University, Xiamen 361003, China.
authors: Lihua
authors: 0000-0002-1631-4675
authors: L
authors: Duan
authors: Department of Rheumatology and Clinical Immunology, The First Hospital of Xiamen University, Xiamen 361003, China.
authors: Yan
authors: Y
authors: Huang
authors: Department of Rheumatology and Clinical Immunology, The First Hospital of Xiamen University, Xiamen 361003, China.
authors: Qun
authors: Q
authors: Su
authors: Department of Rheumatology and Clinical Immunology, The First Hospital of Xiamen University, Xiamen 361003, China.
authors: Qingyan
authors: Q
authors: Lin
authors: Department of Rheumatology and Clinical Immunology, The First Hospital of Xiamen University, Xiamen 361003, China.
authors: Wen
authors: W
authors: Liu
authors: Department of Rheumatology and Clinical Immunology, The First Hospital of Xiamen University, Xiamen 361003, China.
authors: Jiao
authors: 0000-0001-8649-7916
authors: J
authors: Luo
authors: Department of Rheumatology and Clinical Immunology, The First Hospital of Xiamen University, Xiamen 361003, China.
authors: Bing
authors: B
authors: Yu
authors: Department of Rheumatology and Clinical Immunology, The First Hospital of Xiamen University, Xiamen 361003, China.
authors: Yan
authors: 0000-0002-4316-8298
authors: Y
authors: He
authors: Department of Rheumatology and Clinical Immunology, The First Hospital of Xiamen University, Xiamen 361003, China.
authors: Hongyan
authors: 0000-0003-0076-8194
authors: H
authors: Qian
authors: Department of Rheumatology and Clinical Immunology, The First Hospital of Xiamen University, Xiamen 361003, China.
authors: Yuan
authors: Y
authors: Liu
authors: Department of Immunology, Basic Medicine Science, Medical College, Xiamen University, Xiamen 361005, China.
authors: Jie
authors: 0000-0002-6808-1076
authors: J
authors: Chen
authors: Department of Rheumatology and Clinical Immunology, The First Hospital of Xiamen University, Xiamen 361003, China.
authors: Guixiu
authors: 0000-0003-4044-3394
authors: G
authors: Shi
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003404:Creatinine / Q000097:blood; D005260:Female; D006073:Gout / Q000097:blood* / Q000150:complications / Q000503:physiopathology; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000150:complications / Q000503:physiopathology; D000067596:Interleukin-33 / Q000097:blood*; D007668:Kidney / Q000503:physiopathology*; D050356:Lipid Metabolism / Q000502:physiology*; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged; D051436:Renal Insufficiency, Chronic / Q000097:blood* / Q000150:complications / Q000503:physiopathology; D014508:Urea / Q000097:blood
chemical_list: D000067596:Interleukin-33; D008055:Lipids; D014508:Urea; D003404:Creatinine