title: A complication probability planning study to predict the safety of a new protocol for intracranial tumour radiotherapy in dogs.
abstract: Technical advances make it possible to deliver radiation therapy for canine intracranial tumours in fewer fractions, under the assumption of equivalent tumour control. With the aim of estimating the late toxicity risk profile for various tumour sizes and locations, the present paper evaluates the normal tissue complication probability (NTCP) values for the intracranial organs at risk. By making isoeffect calculations, a new 10-fraction radiation protocol was developed with the same tumour control probability (TCP) as a currently used 20-fraction standard protocol, and complication risk profiles for brain, brainstem and optic chiasm were modelled using a representative population of 64 dogs with brain tumours. For >59% of cases, the new 10-fraction protocol yielded an acceptable, low risk estimate of late toxicity (<10%). Our calculations suggest that it may be safe to treat small to intermediate-sized tumours that are neither located near the optic chiasm nor at the brainstem with 10 daily fractions of 4.35 Gy.
authors: Division of Radiation Oncology, Vetsuisse Faculty, University of Zurich, Zurich, Switzerland.
authors: C
authors: C
authors: Rohrer Bley
authors: Division of Radiation Oncology, Vetsuisse Faculty, University of Zurich, Zurich, Switzerland.
authors: V
authors: V
authors: Meier
authors: Division of Radiation Oncology, Vetsuisse Faculty, University of Zurich, Zurich, Switzerland.
authors: P
authors: P
authors: Schwarz
authors: Department of Biostatistics, Epidemiology Biostatistics and Prevention Institute, Faculty of Medicine, University of Zurich, Zurich, Switzerland.
authors: M
authors: M
authors: Roos
authors: Division of Radiation Oncology, Vetsuisse Faculty, University of Zurich, Zurich, Switzerland.|Radiation Oncology, Hirslanden Clinic, Zurich, Switzerland.
authors: J
authors: J
authors: Besserer
mesh_terms: D000818:Animals; D001921:Brain / Q000528:radiation effects; D001932:Brain Neoplasms / Q000532:radiotherapy / Q000662:veterinary*; D001933:Brain Stem / Q000528:radiation effects; D002985:Clinical Protocols; D004283:Dog Diseases / Q000532:radiotherapy*; D004285:Dogs; D005260:Female; D008297:Male; D009897:Optic Chiasm / Q000528:radiation effects; D011336:Probability; D011829:Radiation Dosage; D011878:Radiotherapy / Q000009:adverse effects / Q000662:veterinary*; D018570:Risk Assessment
keywords: brain tumour; canine; fractionation; radiation; risk; toxicity