title: Cellular and molecular effects of yeast probiotics on cancer.
abstract: The cancer is one of the main causes of human deaths worldwide. The exact mechanisms of initiation and progression of malignancies are not clear yet, but there is a common agreement about the role of colonic microbiota in the etiology of different cancers. Probiotics have been examined for their anti-cancer effects, and different mechanisms have been suggested about their antitumor functions. Nonpathogenic yeasts, as members of probiotics family, can be effective on gut microbiota dysbiosis. Generally safe yeasts have shown so many beneficial effects on human health. Probiotic yeasts influence physiology, metabolism, and immune homeostasis in the colon and contribute to cancer treatment due to possessing anti-inflammatory, anti-proliferative and anti-cancer properties. This study reviews some of the health-beneficial effects of probiotic yeasts and their biological substances like folic acid and β-glucan on cancer and focuses on the possible cellular and molecular mechanisms of probiotic yeasts such as influencing pathogenic bacteria, inactivation of carcinogenic compounds, especially those derived from food, improvement of intestinal barrier function, modulation of immune responses, antitoxic function, apoptosis, and anti-proliferative effects.
authors: a Biotechnology Research Center, Faculty of Nutrition, Tabriz University of Medical Sciences , Tabriz , Iran.|b Student Research Committee, Faculty of Nutrition, Tabriz University of Medical Sciences , Tabriz , Iran.|c Department of Biochemistry and Diet Therapy , Faculty of Nutrition, Tabriz University of Medical Sciences , Tabriz , Iran.
authors: Amir
authors: A
authors: Saber
authors: c Department of Biochemistry and Diet Therapy , Faculty of Nutrition, Tabriz University of Medical Sciences , Tabriz , Iran.|d Nutrition Research Center, Faculty of Nutrition, Tabriz University of Medical Sciences , Tabriz , Iran.
authors: Beitollah
authors: B
authors: Alipour
authors: e Faculty of Medicine, Semnan University of Medical Sciences , Semnan , Iran.
authors: Zeinab
authors: Z
authors: Faghfoori
authors: f Drug Applied Research Center, Faculty of Pharmacy, Tabriz University of Medical Sciences , Tabriz , Iran.|g Department of Pharmacognosy , Faculty of Pharmacy, Tabriz University of Medical Sciences , Tabriz , Iran.
authors: Ahmad
authors: A
authors: Yari Khosroushahi
mesh_terms: D000818:Animals; D000069196:Gastrointestinal Microbiome; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy* / Q000276:immunology / Q000382:microbiology; D019936:Probiotics / Q000008:administration & dosage* / Q000032:analysis; D015003:Yeasts / Q000235:genetics / Q000254:growth & development* / Q000302:isolation & purification / Q000378:metabolism
keywords: Anticancer; anti-inflammation; anti-proliferate; apoptosis; microbiota dysbiosis