title: Antidepressants and mortality risk in a dementia cohort: data from SveDem, the Swedish Dementia Registry.
abstract: The association between mortality risk and use of antidepressants in people with dementia is unknown.
  
  
  
  To describe the use of antidepressants in people with different dementia diagnoses and to explore mortality risk associated with use of antidepressants 3 years before a dementia diagnosis.
  
  
  
  Study population included 20 050 memory clinic patients from the Swedish Dementia Registry (SveDem) diagnosed with incident dementia. Data on antidepressants dispensed at the time of dementia diagnosis and during 3-year period before dementia diagnosis were obtained from the Swedish Prescribed Drug Register. Cox regression models were used.
  
  
  
  During a median follow-up of 2 years from dementia diagnosis, 25.8% of dementia patients died. A quarter (25.0%) of patients were on antidepressants at the time of dementia diagnosis, while 21.6% used antidepressants at some point during a 3-year period before a dementia diagnosis. Use of antidepressant treatment for 3 consecutive years before a dementia diagnosis was associated with a lower mortality risk for all dementia disorders and in Alzheimer's disease.
  
  
  
  Antidepressant treatment is common among patients with dementia. Use of antidepressants during prodromal stages may reduce mortality in dementia and specifically in Alzheimer's disease.
authors: Division of Neurogeriatrics, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden. daniela.enache@ki.se.|Southwest Psychiatry, Karolinska University Hospital, Huddinge, Sweden. daniela.enache@ki.se.
authors: D
authors: D
authors: Enache
authors: Division of Clinical Geriatrics, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden.
authors: S-M
authors: SM
authors: Fereshtehnejad
authors: Aging Research Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden.|Institute of Gerontology, School of Health Sciences, Jönköping University, Jönköping, Sweden.
authors: I
authors: I
authors: Kåreholt
authors: Division of Neurogeriatrics, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden.|International Clinical Research Center and St. Anne's University Hospital, Brno, Czech Republic.
authors: P
authors: P
authors: Cermakova
authors: Division of Clinical Geriatrics, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden.|Department of Geriatric Medicine, Karolinska University Hospital, Huddinge, Sweden.
authors: S
authors: S
authors: Garcia-Ptacek
authors: Aging Research Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden.
authors: K
authors: K
authors: Johnell
authors: Division of Neurogeriatrics, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden.|Department of Geriatric Medicine, Karolinska University Hospital, Huddinge, Sweden.
authors: D
authors: D
authors: Religa
authors: Division of Clinical Geriatrics, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden.|Department of Geriatric Medicine, Karolinska University Hospital, Huddinge, Sweden.
authors: V
authors: V
authors: Jelic
authors: Division of Neurogeriatrics, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden.|Department of Geriatric Medicine, Karolinska University Hospital, Huddinge, Sweden.
authors: B
authors: B
authors: Winblad
authors: Wolfson Centre for Age-Related Diseases, King's College London, London, UK.
authors: C
authors: C
authors: Ballard
authors: Division of Neurogeriatrics, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden.|Department of Geriatric Medicine, Karolinska University Hospital, Huddinge, Sweden.|Center for Age-Related Diseases, Psychiatric Clinic, Stavanger University Hospital, Stavanger, Norway.
authors: D
authors: D
authors: Aarsland
authors: Aging Research Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden.
authors: J
authors: J
authors: Fastbom
authors: Division of Clinical Geriatrics, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden.|Department of Geriatric Medicine, Karolinska University Hospital, Huddinge, Sweden.
authors: M
authors: M
authors: Eriksdotter
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000928:Antidepressive Agents / Q000627:therapeutic use*; D003704:Dementia / Q000175:diagnosis* / Q000188:drug therapy / Q000401:mortality*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012042:Registries; D013548:Sweden / Q000453:epidemiology
chemical_list: D000928:Antidepressive Agents
keywords: Alzheimer's disease; antidepressant treatment; dementia; mortality risk