title: IκBζ: an emerging player in cancer.
abstract: IκBζ, an atypical member of the nuclear IκB family of proteins, is expressed at low levels in most resting cells, but is induced upon stimulation of Toll-like/IL-1 receptors through an IRAK1/IRAK4/NFκB-dependent pathway. Like its homolog Bcl3, IκBζ can regulate the transcription of a set of inflamatory genes through its association with the p50 or p52 subunits of NF-κB. Long studied as a key component of the immune response, IκBζ emerges as an important regulator of inflammation, cell proliferation and survival. As a result, growing evidence support the role of this transcription factor in the pathogenesis number of human hematological and solid malignancies.
authors: Department of Human Genetics and GIGA Research Center, University of Liège, Liege, Belgium.
authors: Marie
authors: M
authors: Willems
authors: Department of Human Genetics and GIGA Research Center, University of Liège, Liege, Belgium.
authors: Nadège
authors: N
authors: Dubois
authors: Department of Human Genetics and GIGA Research Center, University of Liège, Liege, Belgium.
authors: Lucia
authors: L
authors: Musumeci
authors: Department of Human Genetics and GIGA Research Center, University of Liège, Liege, Belgium.
authors: Vincent
authors: V
authors: Bours
authors: Department of Human Genetics and GIGA Research Center, University of Liège, Liege, Belgium.|Department of Neurology and Neurosurgery, T&P Bohnenn Laboratory for Neuro-Oncology, Brain Center Rudolf Magnus, University Medical Center of Utrecht, Heidelberglaan, Utrecht, The Netherlands.
authors: Pierre A
authors: PA
authors: Robe
mesh_terms: D000818:Animals; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D020672:I-kappa B Proteins / Q000235:genetics / Q000378:metabolism*; D009369:Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000473:pathology*
chemical_list: D020672:I-kappa B Proteins
keywords: IκBζ; NF-κB pathway; cancer; nuclear IκB protein; perspectives