title: Change of Optical Intensity during Healing Process of Corneal Wound on Anterior Segment Optical Coherence Tomography.
abstract: The purpose of this study is to investigate the process of corneal wound healing after penetrating injury with the change in optical intensity on anterior segment optical coherence tomography (AS-OCT) and to investigate factors associated with severity of corneal scar. Forty-seven eyes from 47 patients with repaired corneal laceration were included. AS-OCT was performed on 1day, 1week, 1, 3 and 6 months after primary repair. Internal aberrations of wound edges were observed on AS-OCT images. Parameters including height of steps, width of gaps, maximal corneal thickness, area and optical intensity of corneal wound/scar were measured. The relationship between the parameters at day 1 and the optical intensity at 6 months were analyzed. The results showed that optical intensity of corneal wound/scar increased from 124.1 ± 18.8 on day 1 postoperatively to 129.3 ± 18.7, 134.2 ± 23.4, 139.7 ± 26.5, 148.2 ± 26.4 at 1 week, 1 month, 3 months and 6 months postoperatively. Height of steps at 1 day after surgery was the only factor identified as correlated with optical intensity of corneal scar at 6 months (beta = 0.34, p = 0.024). The increase of optical intensity represents the process of fibrosis of corneal wound healing. Higher step after suturing is associated with more severity of corneal scar at last.
authors: Joint Shantou International Eye Center, Shantou University &the Chinese University of Hong Kong, Shantou, China.
authors: Kangkeng
authors: K
authors: Zheng
authors: Joint Shantou International Eye Center, Shantou University &the Chinese University of Hong Kong, Shantou, China.
authors: Haifan
authors: H
authors: Huang
authors: Joint Shantou International Eye Center, Shantou University &the Chinese University of Hong Kong, Shantou, China.
authors: Kun
authors: K
authors: Peng
authors: Joint Shantou International Eye Center, Shantou University &the Chinese University of Hong Kong, Shantou, China.
authors: Jianhao
authors: J
authors: Cai
authors: Department of Ophthalmology and Visual Sciences, the Chinese University of Hong Kong, Hong Kong, China.
authors: Vishal
authors: V
authors: Jhanji
authors: Joint Shantou International Eye Center, Shantou University &the Chinese University of Hong Kong, Shantou, China.
authors: Haoyu
authors: H
authors: Chen
mesh_terms: D000293:Adolescent; D000328:Adult; D000869:Anterior Eye Segment / Q000000981:diagnostic imaging* / Q000503:physiopathology; D002648:Child; D003315:Cornea / Q000000981:diagnostic imaging* / Q000503:physiopathology; D065306:Corneal Injuries / Q000000981:diagnostic imaging* / Q000503:physiopathology / Q000628:therapy; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D041623:Tomography, Optical Coherence; D014945:Wound Healing / Q000502:physiology; D055815:Young Adult