title: Distribution of persistent organic pollutants in serum, omental, and parietal adipose tissue of French women with deep infiltrating endometriosis and circulating versus stored ratio as new marker of exposure.
abstract: Several studies have assessed the potential role of environmental chemicals in the onset, growth, and/or physiopathology of endometriosis. However, their contour in terms of considered exposure markers remains limited. The present study aimed to characterize the internal exposure levels of 78 persistent organic pollutants (POPs, including dioxins, polychlorobiphenyls, brominated flame retardants and organochlorine pesticides) in a set of 113 adult French women (45 controls, 68 cases), and to characterize the distribution of these POPs within three biological compartments (omental adipose tissue, parietal adipose tissue, and serum). For all targeted substances, the correlation between the concentrations measured in omental versus parietal adipose tissue was found strongly significant (p<0.0001). An equivalence of the measures performed in parietal and omental adipose tissue was moreover observed with median levels of 6.4 vs. 7.4pg/gl.w. for WHO-TEQ2005PCDD/F, 4.5 vs. 4.7pg/gl.w. for WHO-TEQ2005dl-PCB, 137.1 vs. 147.9ng/gl.w. for sum of 6 ndl-PCB, and 2.1 vs. 2.0ng/gl.w. for sum of 7 i-PBDE, respectively. The same observation was made for individual targeted OCs compounds. Significant correlations were also observed between these concentrations determined in adipose tissue and those measured in serum for dioxins (WHO-TEQ2005PCDD/F=6.1pg/gl.w), PCBs (WHO-TEQ2005dl-PCB=3.6pg/gl.w., sum of 6 ndl-PCB=81.1ng/gl.w.), and brominated flame-retardants (sum of 7 i-PBDE=0.9ng/gl.w.). The circulating versus stored ratio of some exposure markers (Sum PCDDs, 1,2,3,6,7,8-HxCDF, slightly versus highly chlorinated PCBs ratio, PBDE 99 and PBB 153) was found statistically different for control and case individuals. These extended exposure data from deep infiltrating endometriosis patients are the first ones available for France and give a new insight about the equilibrium of chemicals between storage and circulating compartments that should be further considered as new marker of exposure in the context of exposure-health relationship studies.
authors: LUNAM Université, Oniris, USC 1329 Laboratoire d'Etude des Résidus et Contaminants dans les Aliments (LABERCA), Nantes, France; Service de gynécologie-obstétrique, CIC FEA, Hôpital Mère Enfant, CHU Hôtel Dieu, Nantes, France.
authors: Stéphane
authors: S
authors: Ploteau
authors: LUNAM Université, Oniris, USC 1329 Laboratoire d'Etude des Résidus et Contaminants dans les Aliments (LABERCA), Nantes, France; INRA, Nantes F-44307, France. Electronic address: laberca@oniris-nantes.fr.
authors: Jean-Philippe
authors: JP
authors: Antignac
authors: Plateforme Biometrie, CHU Hôtel Dieu, Nantes, France.
authors: Christelle
authors: C
authors: Volteau
authors: LUNAM Université, Oniris, USC 1329 Laboratoire d'Etude des Résidus et Contaminants dans les Aliments (LABERCA), Nantes, France.
authors: Philippe
authors: P
authors: Marchand
authors: LUNAM Université, Oniris, USC 1329 Laboratoire d'Etude des Résidus et Contaminants dans les Aliments (LABERCA), Nantes, France.
authors: Anaïs
authors: A
authors: Vénisseau
authors: LUNAM Université, Oniris, USC 1329 Laboratoire d'Etude des Résidus et Contaminants dans les Aliments (LABERCA), Nantes, France.
authors: Vincent
authors: V
authors: Vacher
authors: LUNAM Université, Oniris, USC 1329 Laboratoire d'Etude des Résidus et Contaminants dans les Aliments (LABERCA), Nantes, France.
authors: Bruno
authors: B
authors: Le Bizec
mesh_terms: D000273:Adipose Tissue / Q000737:chemistry*; D000328:Adult; D015415:Biomarkers / Q000032:analysis / Q000097:blood; D016022:Case-Control Studies; D004147:Dioxins / Q000032:analysis; D004715:Endometriosis / Q000378:metabolism*; D004785:Environmental Pollutants / Q000032:analysis* / Q000097:blood; D005260:Female; D005411:Flame Retardants / Q000032:analysis; D005602:France; D055768:Halogenated Diphenyl Ethers / Q000032:analysis / Q000097:blood; D006801:Humans; D006843:Hydrocarbons, Chlorinated / Q000032:analysis / Q000097:blood; D009852:Omentum / Q000737:chemistry*; D010575:Pesticides / Q000032:analysis / Q000097:blood; D011075:Polybrominated Biphenyls / Q000032:analysis / Q000097:blood; D011078:Polychlorinated Biphenyls / Q000032:analysis; D000072317:Polychlorinated Dibenzodioxins / Q000032:analysis / Q000097:blood
chemical_list: D015415:Biomarkers; D004147:Dioxins; D004785:Environmental Pollutants; D005411:Flame Retardants; D055768:Halogenated Diphenyl Ethers; D006843:Hydrocarbons, Chlorinated; D010575:Pesticides; D011075:Polybrominated Biphenyls; D000072317:Polychlorinated Dibenzodioxins; C086401:pentabromodiphenyl ether; C018566:2,4,5,2',4',5'-hexabromobiphenyl; D011078:Polychlorinated Biphenyls
keywords: Adipose tissue; Dioxin; Endometriosis; OC; PBDE; PCB; Persistent organic pollutants; Serum