title: Circadian rhythms and metabolism: from the brain to the gut and back again.
abstract: This paper focuses on the relationship between the circadian system and glucose metabolism. Research across the translational spectrum confirms the importance of the circadian system for glucose metabolism and offers promising clues as to when and why these systems go awry. In particular, basic research has started to clarify the molecular and genetic mechanisms through which the circadian system regulates metabolism. The study of human behavior, especially in the context of psychiatric disorders, such as bipolar disorder and major depression, forces us to see how inextricably linked mental health and metabolic health are. We also emphasize the remarkable opportunities for advancing circadian science through big data and advanced analytics. Advances in circadian research have translated into environmental and pharmacological interventions with tremendous therapeutic potential.
authors: Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
authors: Matthew R
authors: MR
authors: Cribbet
authors: Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
authors: Ryan W
authors: RW
authors: Logan
authors: Division of Neurobiology, Medical Research Council Laboratory of Molecular Biology, Cambridge, United Kingdom.
authors: Mathew D
authors: MD
authors: Edwards
authors: Department of Medicine, Division of Endocrinology, Metabolism and Molecular Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
authors: Erin
authors: E
authors: Hanlon
authors: Department of Medicine, Division of Endocrinology, Metabolism and Molecular Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
authors: Clara
authors: C
authors: Bien Peek
authors: Department of Neuroscience, University of Texas Southwestern Medical Center, Dallas, Texas.
authors: Jeremy J
authors: JJ
authors: Stubblefield
authors: Department of Pharmacology, University of Oxford, Oxford, England.
authors: Sridhar
authors: S
authors: Vasudevan
authors: Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
authors: Fiona
authors: F
authors: Ritchey
authors: Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
authors: Ellen
authors: E
authors: Frank
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism*; D002940:Circadian Rhythm / Q000502:physiology*; D002986:Clinical Trials as Topic / Q000379:methods; D041981:Gastrointestinal Tract / Q000378:metabolism*; D006801:Humans; D008659:Metabolic Diseases / Q000175:diagnosis / Q000378:metabolism* / Q000523:psychology; D019964:Mood Disorders / Q000175:diagnosis / Q000378:metabolism* / Q000523:psychology
keywords: circadian rhythms; genetics; glucose; metabolism; mood disorders