title: Orolingual angioedema to alteplase. Identify, counsel and monitor at risk patients.
abstract: Orolingual angioedema (OLA) is a known complication of intravenous alteplase used to treat ischaemic stroke. The incidence may be as high as 5.1%. ACE inhibitors are thought to increase the risk of developing this potentially life-threatening complication. This case report demonstrates how we may improve in the identification of risk factors in the history; the counselling of patients appropriately; in seeking alternative therapies such as mechanical thrombectomy; and in the monitoring of patients for signs of OLA once alteplase has been given.
authors: Department of Anaesthetics, Walsall Manor Hospital, Walsall, UK.
authors: Christopher
authors: C
authors: Timmis
authors: Department of Medicine, Walsall Manor Hospital, Walsall, UK.
authors: Elliot
authors: E
authors: Epstein
authors: Department of Anaesthetics, Walsall Manor Hospital, Walsall, UK.
authors: Mohmad
authors: M
authors: Salim
mesh_terms: D000368:Aged; D000799:Angioedema / Q000139:chemically induced*; D005260:Female; D005343:Fibrinolytic Agents / Q000009:adverse effects*; D006801:Humans; D009059:Mouth Diseases / Q000139:chemically induced*; D012307:Risk Factors; D020521:Stroke / Q000188:drug therapy*; D010959:Tissue Plasminogen Activator / Q000009:adverse effects*
chemical_list: D005343:Fibrinolytic Agents; D010959:Tissue Plasminogen Activator