title: Melancholy as a risk factor for cancer: a historical overview.
abstract: In antiquity, physicians related depression or melancholic humour to cancer's pathogenesis. Galen (130-201 AD), sustained that melancholy could give rise to a tumour and his theory was repeated by the Byzantine and Arab physicians. In the 19th century, malignancy and depression became synonymous and people attributed their cancer to sadness. In 1893, the London surgeon Hebert Snow (1847-1930), performed an epidemiological study in order to clarify that link. The results revealed a probable connection. His work was followed by several large scale prospective studies some of which identified depression as a risk factor for cancer where others found no association. However, a possible explanation could be given by our current knowledge in immunology: inflammation and nonspecific immune activation play a role in the pathophysiology of depression and cancer growth.
authors: University Institute of History of Medicine, Faculty of Medicine, Claude Bernard Lyon 1 University, Lyon, France.
authors: Marianna
authors: M
authors: Karamanou
authors: Elias
authors: E
authors: Tzavellas
authors: Konstantinos
authors: K
authors: Laios
authors: Michalis
authors: M
authors: Koutsilieris
authors: George
authors: G
authors: Androutsos
mesh_terms: D003866:Depressive Disorder / Q000150:complications*; D049672:History, 19th Century; D049673:History, 20th Century; D006801:Humans; D008495:Medical Oncology / Q000266:history*; D009369:Neoplasms / Q000209:etiology*; D012307:Risk Factors