title: Human immunodeficiency virus-associated disruption of mucosal barriers and its role in HIV transmission and pathogenesis of HIV/AIDS disease.
abstract: Oral, intestinal and genital mucosal epithelia have a barrier function to prevent paracellular penetration by viral, bacterial and other pathogens, including human immunodeficiency virus (HIV). HIV can overcome these barriers by disrupting the tight and adherens junctions of mucosal epithelia. HIV-associated disruption of epithelial junctions may also facilitate paracellular penetration and dissemination of other viral pathogens. This review focuses on possible molecular mechanisms of HIV-associated disruption of mucosal epithelial junctions and its role in HIV transmission and pathogenesis of HIV and acquired immune deficiency syndrome (AIDS).
authors: Department of Medicine, School of Medicine, University of California, San Francisco, San Francisco, CA, USA; Department of Orofacial Science, School of Dentistry, University of California, San Francisco, San Francisco, CA, USA.
authors: Sharof
authors: S
authors: Tugizov
mesh_terms: D000818:Animals; D002199:Capillary Permeability; D004848:Epithelium / Q000378:metabolism / Q000473:pathology / Q000821:virology*; D015658:HIV Infections / Q000209:etiology / Q000473:pathology* / Q000635:transmission; D006801:Humans; D007365:Intercellular Junctions / Q000378:metabolism / Q000473:pathology* / Q000821:virology; D009092:Mucous Membrane / Q000378:metabolism / Q000473:pathology / Q000821:virology
keywords: disruption of epithelial junctions; human immunodeficiency virus; mucosal epithelium