title: Cortical Thickness and Anxiety Symptoms Among Cognitively Normal Elderly Persons: The Mayo Clinic Study of Aging.
abstract: The authors conducted a cross-sectional study to investigate the association between anxiety symptoms and cortical thickness, as well as amygdalar volume. A total of 1,505 cognitively normal participants, aged ≥70 years, were recruited from the Mayo Clinic Study of Aging in Olmsted County, Minnesota, on whom Beck Anxiety Inventory and 3T brain MRI data were available. Even though the effect sizes were small in this community-dwelling group of participants, anxiety symptoms were associated with reduced global cortical thickness and reduced thickness within the frontal and temporal cortex. However, after additionally adjusting for comorbid depressive symptoms, only the association between anxiety symptoms and reduced insular thickness remained significant.
authors: From the Mayo Clinic Translational Neuroscience and Aging Program, Mayo Clinic, Scottsdale, Ariz. (AP, JK-R, KAS, YEG); the International Clinical Research Center, Brno, Czech Republic (GBS); the Division of Biomedical Statistics and Informatics, Department of Health Sciences Research, Mayo Clinic, Rochester, Minn. (SAP); the Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic, Rochester, Minn. (ROR, MMM, RCP, YEG); the Department of Radiology, Mayo Clinic, Rochester, Minn. (CRJ); the Department of Neurology, Mayo Clinic, Rochester, Minn. (ROR, DSK, RCP); the Department of Psychiatry and Psychology, Mayo Clinic, Scottsdale, Ariz. (YEG); and the Department of Neurology, Mayo Clinic, Scottsdale, Ariz. (YEG).
authors: Anna
authors: A
authors: Pink
authors: From the Mayo Clinic Translational Neuroscience and Aging Program, Mayo Clinic, Scottsdale, Ariz. (AP, JK-R, KAS, YEG); the International Clinical Research Center, Brno, Czech Republic (GBS); the Division of Biomedical Statistics and Informatics, Department of Health Sciences Research, Mayo Clinic, Rochester, Minn. (SAP); the Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic, Rochester, Minn. (ROR, MMM, RCP, YEG); the Department of Radiology, Mayo Clinic, Rochester, Minn. (CRJ); the Department of Neurology, Mayo Clinic, Rochester, Minn. (ROR, DSK, RCP); the Department of Psychiatry and Psychology, Mayo Clinic, Scottsdale, Ariz. (YEG); and the Department of Neurology, Mayo Clinic, Scottsdale, Ariz. (YEG).
authors: Scott A
authors: SA
authors: Przybelski
authors: From the Mayo Clinic Translational Neuroscience and Aging Program, Mayo Clinic, Scottsdale, Ariz. (AP, JK-R, KAS, YEG); the International Clinical Research Center, Brno, Czech Republic (GBS); the Division of Biomedical Statistics and Informatics, Department of Health Sciences Research, Mayo Clinic, Rochester, Minn. (SAP); the Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic, Rochester, Minn. (ROR, MMM, RCP, YEG); the Department of Radiology, Mayo Clinic, Rochester, Minn. (CRJ); the Department of Neurology, Mayo Clinic, Rochester, Minn. (ROR, DSK, RCP); the Department of Psychiatry and Psychology, Mayo Clinic, Scottsdale, Ariz. (YEG); and the Department of Neurology, Mayo Clinic, Scottsdale, Ariz. (YEG).
authors: Janina
authors: J
authors: Krell-Roesch
authors: From the Mayo Clinic Translational Neuroscience and Aging Program, Mayo Clinic, Scottsdale, Ariz. (AP, JK-R, KAS, YEG); the International Clinical Research Center, Brno, Czech Republic (GBS); the Division of Biomedical Statistics and Informatics, Department of Health Sciences Research, Mayo Clinic, Rochester, Minn. (SAP); the Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic, Rochester, Minn. (ROR, MMM, RCP, YEG); the Department of Radiology, Mayo Clinic, Rochester, Minn. (CRJ); the Department of Neurology, Mayo Clinic, Rochester, Minn. (ROR, DSK, RCP); the Department of Psychiatry and Psychology, Mayo Clinic, Scottsdale, Ariz. (YEG); and the Department of Neurology, Mayo Clinic, Scottsdale, Ariz. (YEG).
authors: Gorazd B
authors: GB
authors: Stokin
authors: From the Mayo Clinic Translational Neuroscience and Aging Program, Mayo Clinic, Scottsdale, Ariz. (AP, JK-R, KAS, YEG); the International Clinical Research Center, Brno, Czech Republic (GBS); the Division of Biomedical Statistics and Informatics, Department of Health Sciences Research, Mayo Clinic, Rochester, Minn. (SAP); the Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic, Rochester, Minn. (ROR, MMM, RCP, YEG); the Department of Radiology, Mayo Clinic, Rochester, Minn. (CRJ); the Department of Neurology, Mayo Clinic, Rochester, Minn. (ROR, DSK, RCP); the Department of Psychiatry and Psychology, Mayo Clinic, Scottsdale, Ariz. (YEG); and the Department of Neurology, Mayo Clinic, Scottsdale, Ariz. (YEG).
authors: Rosebud O
authors: RO
authors: Roberts
authors: From the Mayo Clinic Translational Neuroscience and Aging Program, Mayo Clinic, Scottsdale, Ariz. (AP, JK-R, KAS, YEG); the International Clinical Research Center, Brno, Czech Republic (GBS); the Division of Biomedical Statistics and Informatics, Department of Health Sciences Research, Mayo Clinic, Rochester, Minn. (SAP); the Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic, Rochester, Minn. (ROR, MMM, RCP, YEG); the Department of Radiology, Mayo Clinic, Rochester, Minn. (CRJ); the Department of Neurology, Mayo Clinic, Rochester, Minn. (ROR, DSK, RCP); the Department of Psychiatry and Psychology, Mayo Clinic, Scottsdale, Ariz. (YEG); and the Department of Neurology, Mayo Clinic, Scottsdale, Ariz. (YEG).
authors: Michelle M
authors: MM
authors: Mielke
authors: From the Mayo Clinic Translational Neuroscience and Aging Program, Mayo Clinic, Scottsdale, Ariz. (AP, JK-R, KAS, YEG); the International Clinical Research Center, Brno, Czech Republic (GBS); the Division of Biomedical Statistics and Informatics, Department of Health Sciences Research, Mayo Clinic, Rochester, Minn. (SAP); the Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic, Rochester, Minn. (ROR, MMM, RCP, YEG); the Department of Radiology, Mayo Clinic, Rochester, Minn. (CRJ); the Department of Neurology, Mayo Clinic, Rochester, Minn. (ROR, DSK, RCP); the Department of Psychiatry and Psychology, Mayo Clinic, Scottsdale, Ariz. (YEG); and the Department of Neurology, Mayo Clinic, Scottsdale, Ariz. (YEG).
authors: Kathleen A
authors: KA
authors: Spangehl
authors: From the Mayo Clinic Translational Neuroscience and Aging Program, Mayo Clinic, Scottsdale, Ariz. (AP, JK-R, KAS, YEG); the International Clinical Research Center, Brno, Czech Republic (GBS); the Division of Biomedical Statistics and Informatics, Department of Health Sciences Research, Mayo Clinic, Rochester, Minn. (SAP); the Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic, Rochester, Minn. (ROR, MMM, RCP, YEG); the Department of Radiology, Mayo Clinic, Rochester, Minn. (CRJ); the Department of Neurology, Mayo Clinic, Rochester, Minn. (ROR, DSK, RCP); the Department of Psychiatry and Psychology, Mayo Clinic, Scottsdale, Ariz. (YEG); and the Department of Neurology, Mayo Clinic, Scottsdale, Ariz. (YEG).
authors: David S
authors: DS
authors: Knopman
authors: From the Mayo Clinic Translational Neuroscience and Aging Program, Mayo Clinic, Scottsdale, Ariz. (AP, JK-R, KAS, YEG); the International Clinical Research Center, Brno, Czech Republic (GBS); the Division of Biomedical Statistics and Informatics, Department of Health Sciences Research, Mayo Clinic, Rochester, Minn. (SAP); the Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic, Rochester, Minn. (ROR, MMM, RCP, YEG); the Department of Radiology, Mayo Clinic, Rochester, Minn. (CRJ); the Department of Neurology, Mayo Clinic, Rochester, Minn. (ROR, DSK, RCP); the Department of Psychiatry and Psychology, Mayo Clinic, Scottsdale, Ariz. (YEG); and the Department of Neurology, Mayo Clinic, Scottsdale, Ariz. (YEG).
authors: Clifford R
authors: CR
authors: Jack
authors: From the Mayo Clinic Translational Neuroscience and Aging Program, Mayo Clinic, Scottsdale, Ariz. (AP, JK-R, KAS, YEG); the International Clinical Research Center, Brno, Czech Republic (GBS); the Division of Biomedical Statistics and Informatics, Department of Health Sciences Research, Mayo Clinic, Rochester, Minn. (SAP); the Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic, Rochester, Minn. (ROR, MMM, RCP, YEG); the Department of Radiology, Mayo Clinic, Rochester, Minn. (CRJ); the Department of Neurology, Mayo Clinic, Rochester, Minn. (ROR, DSK, RCP); the Department of Psychiatry and Psychology, Mayo Clinic, Scottsdale, Ariz. (YEG); and the Department of Neurology, Mayo Clinic, Scottsdale, Ariz. (YEG).
authors: Ronald C
authors: RC
authors: Petersen
authors: From the Mayo Clinic Translational Neuroscience and Aging Program, Mayo Clinic, Scottsdale, Ariz. (AP, JK-R, KAS, YEG); the International Clinical Research Center, Brno, Czech Republic (GBS); the Division of Biomedical Statistics and Informatics, Department of Health Sciences Research, Mayo Clinic, Rochester, Minn. (SAP); the Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic, Rochester, Minn. (ROR, MMM, RCP, YEG); the Department of Radiology, Mayo Clinic, Rochester, Minn. (CRJ); the Department of Neurology, Mayo Clinic, Rochester, Minn. (ROR, DSK, RCP); the Department of Psychiatry and Psychology, Mayo Clinic, Scottsdale, Ariz. (YEG); and the Department of Neurology, Mayo Clinic, Scottsdale, Ariz. (YEG).
authors: Yonas E
authors: YE
authors: Geda
mesh_terms: D000368:Aged; D000375:Aging / Q000473:pathology* / Q000523:psychology*; D001007:Anxiety / Q000000981:diagnostic imaging* / Q000453:epidemiology; D053327:Apolipoprotein E4 / Q000235:genetics; D002540:Cerebral Cortex / Q000000981:diagnostic imaging*; D015897:Comorbidity; D003430:Cross-Sectional Studies; D003863:Depression / Q000000981:diagnostic imaging / Q000453:epidemiology; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008910:Minnesota / Q000453:epidemiology; D009929:Organ Size; D011569:Psychiatric Status Rating Scales
chemical_list: D053327:Apolipoprotein E4
keywords: Biological Markers; Neuropsychology