title: The Effect of Passive Movement for Paretic Ankle-Foot and Brain Activity in Post-Stroke Patients.
abstract: This study aims at investigating the short-term efficacy of the continuous passive motion (CPM) device developed for the therapy of ankle-foot paresis and to investigate by fMRI the blood oxygen level-dependent responses (BOLD) during ankle passive movement (PM).
  
  
  
  Sixty-four stroke patients were investigated. Patients were assigned into 2 groups: 49 patients received both 15 min manual and 30 min device therapy (M + D), while the other group (n = 15) received only 15 min manual therapy (M). A third group of stroke patients (n = 12) was investigated by fMRI before and immediately after 30 min CPM device therapy. There was no direct relation between the fMRI group and the other 2 groups. All subjects were assessed using the Modified Ashworth Scale (MAS) and a goniometer.
  
  
  
  Mean MAS decreased, the ankle's mean plantar flexion and dorsiflexion passive range of motion (PROM) increased and the equinovalgus improved significantly in the M + D group. In the fMRI group, the PM of the paretic ankle increased BOLD responses; this was observed in the contralateral pre- and postcentral gyrus, superior temporal gyrus, central opercular cortex, and in the ipsilateral postcentral gyrus, frontal operculum cortex and cerebellum.
  
  
  
  Manual therapy with CPM device therapy improved the ankle PROM, equinovalgus and severity of spasticity. The ankle PM increased ipsi- and contralateral cortical activation.
authors: Department of Neurology, University of Debrecen, Debrecen, Hungary.
authors: Csilla
authors: C
authors: Vér
authors: Miklós
authors: M
authors: Emri
authors: Tamás
authors: T
authors: Spisák
authors: Ervin
authors: E
authors: Berényi
authors: Kázmér
authors: K
authors: Kovács
authors: Péter
authors: P
authors: Katona
authors: László
authors: L
authors: Balkay
authors: László
authors: L
authors: Menyhárt
authors: László
authors: L
authors: Kardos
authors: László
authors: L
authors: Csiba
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000842:Ankle / Q000294:innervation* / Q000503:physiopathology; D053587:Arthrometry, Articular; D001921:Brain / Q000503:physiopathology*; D003131:Combined Modality Therapy; D004867:Equipment Design; D005260:Female; D005528:Foot / Q000294:innervation* / Q000503:physiopathology; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D015915:Motion Therapy, Continuous Passive / Q000295:instrumentation*; D026201:Musculoskeletal Manipulations; D009460:Neurologic Examination; D010100:Oxygen / Q000097:blood; D010291:Paresis / Q000503:physiopathology* / Q000534:rehabilitation*; D020521:Stroke / Q000503:physiopathology*; D000071939:Stroke Rehabilitation / Q000295:instrumentation*
chemical_list: D010100:Oxygen