title: 24-h Multichannel Intraluminal Impedance PH-metry 1 Year After Laparocopic Sleeve Gastrectomy: an Objective Assessment of Gastroesophageal Reflux Disease.
abstract: It is not yet clear if laparoscopic sleeve gastrectomy (LSG) causes newly onset gastroesophageal reflux (GERD) or worsens already existing GERD. This is due to the absence of prospective studies using objective assessment measures of GERD such as pH monitoring. Our study aims at assessing GERD 1-year post-LSG procedure for obesity.
  
  
  
  Twelve asymptomatic obese patients were studied prospectively by using 24-h multichannel intraluminal impedance-pHmetry (MIIpH) pre- and 12 months post-LSG.
  
  
  
  Of patients' 1-year post-LSG, 83.33 % of patients' suffer from GERD (either newly onset or worsening of already existing) as indicated by abnormal DeMeester score. Mean DeMeester score 1-year post LSG was 47, almost 2.5 times higher than the preoperative score (p = 0.072). The percentage of total time with pH lower than four was statistically significant higher postoperatively (13.27 % vs 3.87 %, p = 0.048).
  
  
  
  This study is one of the few assessing GERD post-LSG by using 24-h MIIpH. The majority of patients suffer from GERD 12 months postoperatively, implying that close postoperative monitor for GERD with the use of pH testing and upper gastrointestinal endoscopy in order to early diagnose GERD and identify possible mucosal injury and also a prophylactic proton pump inhibitor use may be of great importance.
authors: Foregut Department, 1st Propaedeutic Surgical Department, Hippokration General Hospital of Athens, National and Kapodistrian University of Athens, 114 Vas Sofias Av, 115 27, Athens, Greece. tzinagb@yahoo.gr.
authors: Doulami
authors: D
authors: Georgia
authors: Foregut Department, 1st Propaedeutic Surgical Department, Hippokration General Hospital of Athens, National and Kapodistrian University of Athens, 114 Vas Sofias Av, 115 27, Athens, Greece.
authors: Triantafyllou
authors: T
authors: Stamatina
authors: Bariatric Surgery Department, 1st Propaedeutic Surgical Department, Hippokration General Hospital of Athens, National and Kapodistrian University of Athens, Athens, Greece.
authors: Natoudi
authors: N
authors: Maria
authors: Bariatric Surgery Department, 1st Propaedeutic Surgical Department, Hippokration General Hospital of Athens, National and Kapodistrian University of Athens, Athens, Greece.
authors: Albanopoulos
authors: A
authors: Konstantinos
authors: 1st Propaedeutic Surgical Department, Hippokration General Hospital of Athens, National and Kapodistrian University of Athens, Athens, Greece.
authors: Filis
authors: F
authors: Konstantinos
authors: Bariatric Surgery Department, 1st Propaedeutic Surgical Department, Hippokration General Hospital of Athens, National and Kapodistrian University of Athens, Athens, Greece.
authors: Leandros
authors: L
authors: Emmanouil
authors: 1st Propaedeutic Surgical Department, Hippokration General Hospital of Athens, National and Kapodistrian University of Athens, Athens, Greece.
authors: Zografos
authors: Z
authors: Georgios
authors: Foregut Department, 1st Propaedeutic Surgical Department, Hippokration General Hospital of Athens, National and Kapodistrian University of Athens, 114 Vas Sofias Av, 115 27, Athens, Greece.
authors: Theodorou
authors: T
authors: Dimitrios
mesh_terms: D000328:Adult; D050110:Bariatric Surgery / Q000009:adverse effects* / Q000379:methods; D017097:Electric Impedance; D050782:Esophageal pH Monitoring / Q000379:methods*; D005260:Female; D005743:Gastrectomy / Q000009:adverse effects* / Q000379:methods; D005764:Gastroesophageal Reflux / Q000175:diagnosis / Q000209:etiology*; D006801:Humans; D010535:Laparoscopy / Q000379:methods; D008297:Male; D008875:Middle Aged; D009767:Obesity, Morbid / Q000601:surgery*; D011184:Postoperative Period; D011446:Prospective Studies; D016896:Treatment Outcome
keywords: Gastroesophageal reflux; MIIpH; Sleeve gastrectomy