title: In vivo triglyceride composition of abdominal adipose tissue measured by1H MRS at 3T.
abstract: To investigate the regional variability of adipose tissue triglyceride composition in vivo using1H MRS, examining potential confounders and corrections for artifacts, to allow for adipose tissue spectrum estimation.
  
  
  
  1H magnetic resonance (MR) stimulated echo acquisition mode (STEAM) spectra were acquired in vivo at 3T from 340 adult patients (mean age 48.9 years, range 21-79 years; 172 males, 168 females; mean body mass index [BMI] 34.0, range 22-49 kg/m2) with known or suspected nonalcoholic fatty liver disease (NAFLD) in deep (dSCAT), surface (sSCAT) subcutaneous adipose tissue, and visceral adipose tissue (VAT). Triglyceride composition was characterized by the number of double bonds (ndb) and number of methylene-interrupted double bonds (nmidb). A subset of patients (dSCAT n = 80, sSCAT n = 55, VAT n = 194) had the acquisition repeated three times to examine the repeatability of ndb and nmidb estimation.
  
  
  
  Mean ndb and nmidb showed significant (P < 0.0001) differences between depots except for dSCAT and sSCAT nmidb (dSCAT ndb 2.797, nmidb 0.745; sSCAT ndb 2.826, nmidb 0.737; VAT ndb 2.723, nmidb 0.687). All ndb and nmidb estimates were highly repeatable (VAT ndb ICC = 0.888, nmidb ICC = 0.853; sSCAT: ndb ICC = 0.974, nmidb ICC = 0.964; dSCAT: ndb ICC = 0.959, nmidb ICC = 0.948).
  
  
  
  Adipose tissue composition can be estimated repeatably using1H MRS and different fat depots have different triglyceride compositions.
  
  
  
  2 J. MAGN. RESON. IMAGING 2017;45:1455-1463.
authors: Liver Imaging Group, Department of Radiology, University of California, San Diego, San Diego, California, USA.
authors: Gavin
authors: G
authors: Hamilton
authors: Liver Imaging Group, Department of Radiology, University of California, San Diego, San Diego, California, USA.
authors: Alexandra N
authors: AN
authors: Schlein
authors: Liver Imaging Group, Department of Radiology, University of California, San Diego, San Diego, California, USA.
authors: Michael S
authors: MS
authors: Middleton
authors: Liver Imaging Group, Department of Radiology, University of California, San Diego, San Diego, California, USA.
authors: Catherine A
authors: CA
authors: Hooker
authors: Computational and Applied Statistics Lab, San Diego Supercomputing Center, San Diego, California, USA.
authors: Tanya
authors: T
authors: Wolfson
authors: Computational and Applied Statistics Lab, San Diego Supercomputing Center, San Diego, California, USA.
authors: Anthony C
authors: AC
authors: Gamst
authors: Department of Family Medicine and Public Health, University of California, San Diego, San Diego, California, USA.|NAFLD Translational Research Unit, Division of Gastroenterology, Department of Medicine, University of California, San Diego, San Diego, California, USA.
authors: Rohit
authors: R
authors: Loomba
authors: Liver Imaging Group, Department of Radiology, University of California, San Diego, San Diego, California, USA.
authors: Claude B
authors: CB
authors: Sirlin
mesh_terms: D050153:Abdominal Fat / Q000000981:diagnostic imaging*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016477:Artifacts; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D050152:Intra-Abdominal Fat / Q000000981:diagnostic imaging*; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D008875:Middle Aged; D019047:Phantoms, Imaging; D011446:Prospective Studies; D066244:Proton Magnetic Resonance Spectroscopy; D050151:Subcutaneous Fat / Q000000981:diagnostic imaging*; D014280:Triglycerides / Q000737:chemistry*; D055815:Young Adult
chemical_list: D014280:Triglycerides
keywords: adipose tissue; fatty acids; magnetic resonance spectroscopy; triglyceride composition