title: Tidal volume delivery during continuous chest compressions and sustained inflation.
abstract: OBJECTIVE
  To determine the distending pressure needed to achieve sufficient tidal volume (VT) delivery during continuous chest compressions (CC) superimposed by sustained inflation (SI) (CC+SI).
  
  
  METHODS
  Randomised animal/manikin trial.
  
  
  METHODS
  University laboratory.
  
  
  METHODS
  Cadaver piglets/manikin.
  
  
  METHODS
  SI distending pressures of 5, 10, 15, 20, 25 and 30 cm H2O were delivered in random order during CC+SI for 2 min each.
  
  
  METHODS
  VT, gas flow and airway pressure. Spearman's r for distending pressure and VT.
  
  
  RESULTS
  Distending pressure and VTcorrelated in cadaver piglets (r=0.83, p<0.001), manikin (r=0.98, p<0.001) and combined data (r=0.49, p<0.001). VTwas delivered during chest recoil during CC in both models. In cadaver piglets, a distending pressure ∼25 cm H2O was needed to achieve an adequate VT.
  
  
  CONCLUSIONS
  Chest recoil generates VTdepending on an adequate distending pressure. This has previously been demonstrated in adult animals. A pressure of ∼25 cm H2O is needed to achieve an adequate VTdelivery.
authors: Centre for the Studies of Asphyxia and Resuscitation, Neonatal Research Unit, Royal Alexandra Hospital, Edmonton, Alberta, Canada.|Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada.|Department of Pediatric and Adolescent Medicine, Akershus University Hospital, Lørenskog, Norway.
authors: A L
authors: AL
authors: Solevåg
authors: Centre for the Studies of Asphyxia and Resuscitation, Neonatal Research Unit, Royal Alexandra Hospital, Edmonton, Alberta, Canada.|Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada.
authors: T-F
authors: TF
authors: Lee
authors: Centre for the Studies of Asphyxia and Resuscitation, Neonatal Research Unit, Royal Alexandra Hospital, Edmonton, Alberta, Canada.|Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada.
authors: M
authors: M
authors: Lu
authors: Centre for the Studies of Asphyxia and Resuscitation, Neonatal Research Unit, Royal Alexandra Hospital, Edmonton, Alberta, Canada.|Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada.
authors: G M
authors: GM
authors: Schmölzer
authors: Centre for the Studies of Asphyxia and Resuscitation, Neonatal Research Unit, Royal Alexandra Hospital, Edmonton, Alberta, Canada.|Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada.
authors: P-Y
authors: PY
authors: Cheung
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D002102:Cadaver; D016887:Cardiopulmonary Resuscitation / Q000379:methods*; D004195:Disease Models, Animal; D006323:Heart Arrest / Q000628:therapy*; D006801:Humans; D007231:Infant, Newborn; D007327:Insufflation / Q000379:methods*; D008348:Manikins; D011312:Pressure; D013552:Swine; D035441:Thoracic Wall; D013990:Tidal Volume / Q000502:physiology*
keywords: Neonatology; Resuscitation