title: Effect of Consuming Oat Bran Mixed in Water before a Meal on Glycemic Responses in Healthy Humans-A Pilot Study.
abstract: BACKGROUND
  Viscous dietary fibers including oat β-glucan are one of the most effective classes of functional food ingredients for reducing postprandial blood glucose. The mechanism of action is thought to be via an increase in viscosity of the stomach contents that delays gastric emptying and reduces mixing of food with digestive enzymes, which, in turn, retards glucose absorption. Previous studies suggest that taking viscous fibers separate from a meal may not be effective in reducing postprandial glycemia.
  
  
  METHODS
  We aimed to re-assess the effect of consuming a preload of a commercially available oat-bran (4.5, 13.6 or 27.3 g) containing 22% of high molecular weight oat β-glucan (O22 (OatWell(®)22)) mixed in water before a test-meal of white bread on glycemic responses in 10 healthy humans.
  
  
  RESULTS
  We found a significant effect of dose on blood glucose area under the curve (AUC) (p = 0.006) with AUC after 27.3 g of O22 being significantly lower than white bread only. Linear regression analysis showed that each gram of oat β-glucan reduced glucose AUC by 4.35% ± 1.20% (r = 0.507, p = 0.0008, n = 40) and peak rise by 6.57% ± 1.49% (r = 0.582, p < 0.0001).
  
  
  CONCLUSIONS
  These data suggest the use of oat bran as nutritional preload strategy in the management of postprandial glycemia.
authors: DSM Nutritional Products Ltd., R & D Human Nutrition and Health, Basel 4057, Switzerland. robert.steinert@dsm.com.
authors: Robert E
authors: RE
authors: Steinert
authors: DSM Nutritional Products Ltd., R & D Human Nutrition and Health, Basel 4057, Switzerland. daniel.raederstorff@dsm.com.
authors: Daniel
authors: D
authors: Raederstorff
authors: Glycemic Index Laboratories, Inc., Toronto, ON M5C 2N8, Canada. thomas.wolever@utoronto.ca.
authors: Thomas M S
authors: TM
authors: Wolever
mesh_terms: D000328:Adult; D000368:Aged; D019540:Area Under Curve; D018554:Avena; D001628:Beverages; D015415:Biomarkers / Q000097:blood; D001786:Blood Glucose / Q000378:metabolism*; D001939:Bread; D004043:Dietary Fiber / Q000008:administration & dosage*; D019587:Dietary Supplements; D005260:Female; D064368:Healthy Volunteers; D006801:Humans; D006943:Hyperglycemia / Q000097:blood / Q000175:diagnosis / Q000209:etiology / Q000517:prevention & control*; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D010865:Pilot Projects; D019518:Postprandial Period; D013997:Time Factors; D014783:Viscosity; D014867:Water / Q000008:administration & dosage*; D055815:Young Adult; D047071:beta-Glucans / Q000008:administration & dosage*
chemical_list: D015415:Biomarkers; D001786:Blood Glucose; D004043:Dietary Fiber; D047071:beta-Glucans; D014867:Water
keywords: blood glucose; dietary fibre; postprandial glycemia; preload; type 2 diabetes mellitus