title: Microwave-assisted synthesis of (aminomethylene)bisphosphine oxides and (aminomethylene)bisphosphonates by a three-component condensation.
abstract: A practical method was elaborated for the synthesis of (aminomethylene)bisphosphine oxides comprising the catalyst- and solvent-free microwave-assisted three-component condensation of primary amines, triethyl orthoformate and two equivalents of diphenylphosphine oxide. The method is also suitable for the preparation of (aminomethylene)bisphosphonates using (MeO)2P(O)H/(MeO)3CH or (EtO)2P(O)H/(EtO)3CH reactant pairs and even secondary amines. Several intermediates referring to the reaction mechanism together with a few by-products could also be identified.
authors: MTA-BME Research Group for Organic Chemical Technology, 1521 Budapest, Hungary.
authors: Erika
authors: E
authors: Bálint
authors: Department of Organic Chemistry and Technology, Budapest University of Technology and Economics, 1521 Budapest, Hungary.
authors: Ádám
authors: Á
authors: Tajti
authors: Department of Organic Chemistry and Technology, Budapest University of Technology and Economics, 1521 Budapest, Hungary.
authors: Anna
authors: A
authors: Dzielak
authors: Institute of Inorganic Chemistry, Heinrich-Heine-University Düsseldorf, 40225 Düsseldorf, Germany.
authors: Gerhard
authors: G
authors: Hägele
authors: Department of Organic Chemistry and Technology, Budapest University of Technology and Economics, 1521 Budapest, Hungary.
authors: György
authors: G
authors: Keglevich
keywords: (aminomethylene)bisphosphine oxides; (aminomethylene)bisphosphonates; microwave; three-component condensation