title: A Multicenter Retrospective Case Study of Anaphylaxis Triggers by Age in Korean Children.
abstract: OBJECTIVE
  Although anaphylaxis is recognized as an important, life-threatening condition, data are limited regarding its triggers in different age groups. We aimed to identify anaphylaxis triggers by age in Korean children.
  
  
  METHODS
  We performed a retrospective review of medical records for children diagnosed with anaphylaxis between 2009 and 2013 in 23 secondary or tertiary hospitals in South Korea.
  
  
  RESULTS
  A total of 991 cases (mean age=5.89±5.24) were reported, with 63.9% involving patients younger than 6 years of age and 66% involving male children. Food was the most common anaphylaxis trigger (74.7%), followed by drugs and radiocontrast media (10.7%), idiopathic factors (9.2%), and exercise (3.6%). The most common food allergen was milk (28.4%), followed by egg white (13.6%), walnut (8.0%), wheat (7.2%), buckwheat (6.5%), and peanut (6.2%). Milk and seafood were the most common anaphylaxis triggers in young and older children, respectively. Drug-triggered anaphylaxis was observed more frequently with increasing age, with antibiotics (34.9%) and nonsteroidal anti-inflammatory drugs (17.9%) being the most common causes.
  
  
  CONCLUSIONS
  The most common anaphylaxis trigger in Korean children was food. Data on these triggers show that their relative frequency may vary by age.
authors: Department of Pediatrics, Hallym University College of Medicine, Seoul, Korea.
authors: So Yeon
authors: SY
authors: Lee
authors: Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
authors: Kangmo
authors: K
authors: Ahn
authors: Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
authors: Jihyun
authors: J
authors: Kim
authors: Department of Pediatrics, National Health Insurance Corporation Ilsan Hospital, Seoul, Korea.
authors: Gwang Cheon
authors: GC
authors: Jang
authors: Department of Pediatrics, Soonchunhyang University Hospital, Seoul, Korea.
authors: Taek Ki
authors: TK
authors: Min
authors: Department of Pediatrics, Soonchunhyang University Hospital, Seoul, Korea.
authors: Hyeon Jong
authors: HJ
authors: Yang
authors: Department of Pediatrics, Soonchunhyang University Hospital, Seoul, Korea.
authors: Bok Yang
authors: BY
authors: Pyun
authors: Department of Pediatrics, Seoul National University College of Medicine, Seoul, Korea.
authors: Ji Won
authors: JW
authors: Kwon
authors: Department of Pediatrics, Yonsei University College of Medicine, Seoul, Korea.
authors: Myung Hyun
authors: MH
authors: Sohn
authors: Department of Pediatrics, Yonsei University College of Medicine, Seoul, Korea.
authors: Kyung Won
authors: KW
authors: Kim
authors: Department of Pediatrics, Yonsei University College of Medicine, Seoul, Korea.
authors: Kyu Earn
authors: KE
authors: Kim
authors: Department of Pediatrics, University of Ulsan College of Medicine, Seoul, Korea.
authors: Jinho
authors: J
authors: Yu
authors: Department of Pediatrics, University of Ulsan College of Medicine, Seoul, Korea.
authors: Soo Jong
authors: SJ
authors: Hong
authors: Department of Pediatrics, Korea University, College of Medicine, Seoul, Korea.
authors: Jung Hyun
authors: JH
authors: Kwon
authors: Department of Pediatrics, Pusan Saint Maria Hospital, Busan, Korea.
authors: Sung Won
authors: SW
authors: Kim
authors: Department of Pediatrics, Inje University College of Medicine, Seoul, Korea.
authors: Tae Won
authors: TW
authors: Song
authors: Department of Pediatrics, Inje University College of Medicine, Seoul, Korea.
authors: Woo Kyung
authors: WK
authors: Kim
authors: Department of Pediatrics, Pusan National University School of Medicine, Yangsan, Korea.
authors: Hyung Young
authors: HY
authors: Kim
authors: Department of Pediatrics, Hallym University College of Medicine, Seoul, Korea.
authors: You Hoon
authors: YH
authors: Jeon
authors: Department of Pediatrics, Hallym University College of Medicine, Seoul, Korea.
authors: Yong Ju
authors: YJ
authors: Lee
authors: Department of Pediatrics, Hallym University College of Medicine, Seoul, Korea.
authors: Hae Ran
authors: HR
authors: Lee
authors: Department of Pediatrics, Pusan National University School of Medicine, Yangsan, Korea.
authors: Hye Young
authors: HY
authors: Kim
authors: Department of Pediatrics, Eulji University School of Medicine, Seoul, Korea.
authors: Youngmin
authors: Y
authors: Ahn
authors: Department of Pediatrics, Seoul Medical Center, Seoul, Korea.
authors: Hye Yung
authors: HY
authors: Yum
authors: Department of Pediatrics, Seoul National University College of Medicine, Seoul, Korea.
authors: Dong In
authors: DI
authors: Suh
authors: Department of Pediatrics, The Catholic University of Korea College of Medicine, Seoul, Korea.
authors: Hyun Hee
authors: HH
authors: Kim
authors: Department of Pediatrics, The Catholic University of Korea College of Medicine, Seoul, Korea.
authors: Jin Tack
authors: JT
authors: Kim
authors: Department of Pediatrics, Inha University College of Medicine, Incheon, Korea.
authors: Jeong Hee
authors: JH
authors: Kim
authors: Department of Pediatrics, Konkuk University School of Medicine, Seoul, Korea.
authors: Yong Mean
authors: YM
authors: Park
authors: Department of Pediatrics, Ajou University School of Medicine, Suwon, Korea. jsjs87@ajou.ac.kr.
authors: Sooyoung
authors: S
authors: Lee
keywords: Anaphylaxis; children; epidemiology