title: Phase-stable swept source OCT angiography in human skin using an akinetic source.
abstract: We demonstrate noninvasive structural and microvascular contrast imaging of human skin in vivo, using phase difference swept source OCT angiography (pOCTA). The pOCTA system employs an akinetic, all-semiconductor, highly phase-stable swept laser source which operates at 1340 nm central wavelength, with 37 nm bandwidth (at 0 dB region) and 200 kHz A-scan rate. The phase sensitive detection does not need any external phase stabilizing implementations, due to the outstanding high phase linearity and sweep phase repeatability within 2 mrad. We compare the performance of phase based OCTA to speckle based OCTA for visualizing human vascular networks. pOCTA shows better contrast especially for deeper vascular details as compared to speckle based OCTA. The phase stability of the akinetic source allows the OCTA system to show decent vascular contrast only with 2 B-scans. We compare the performance of using 2 versus 4 B-scans for calculating the vascular contrast. Finally, the performance of a 100 nm bandwidth akinetic laser at 1310 nm is investigated for both OCT and OCTA.
authors: Center of Medical Physics and Biomedical Engineering, Medical University Vienna, Währinger Gürtel 18-20, 1090 Vienna, Austria.
authors: Zhe
authors: Z
authors: Chen
authors: Center of Medical Physics and Biomedical Engineering, Medical University Vienna, Währinger Gürtel 18-20, 1090 Vienna, Austria.
authors: Mengyang
authors: M
authors: Liu
authors: Insight Photonic Solutions, Inc., 300 S. Public Rd., Lafayette CO 80026, USA.
authors: Michael
authors: M
authors: Minneman
authors: Center of Medical Physics and Biomedical Engineering, Medical University Vienna, Währinger Gürtel 18-20, 1090 Vienna, Austria; Christian Doppler Laboratory for Innovative Optical Imaging and its Translation to Medicine, Währinger Gürtel 18-20, 1090 Vienna, Austria.
authors: Laurin
authors: L
authors: Ginner
authors: Insight Photonic Solutions, Inc., 300 S. Public Rd., Lafayette CO 80026, USA.
authors: Erich
authors: E
authors: Hoover
authors: Center of Medical Physics and Biomedical Engineering, Medical University Vienna, Währinger Gürtel 18-20, 1090 Vienna, Austria; Insight Photonic Solutions, Inc., 300 S. Public Rd., Lafayette CO 80026, USA.
authors: Harald
authors: H
authors: Sattmann
authors: Center of Medical Physics and Biomedical Engineering, Medical University Vienna, Währinger Gürtel 18-20, 1090 Vienna, Austria.
authors: Marco
authors: M
authors: Bonesi
authors: Center of Medical Physics and Biomedical Engineering, Medical University Vienna, Währinger Gürtel 18-20, 1090 Vienna, Austria.
authors: Wolfgang
authors: W
authors: Drexler
authors: Center of Medical Physics and Biomedical Engineering, Medical University Vienna, Währinger Gürtel 18-20, 1090 Vienna, Austria; Christian Doppler Laboratory for Innovative Optical Imaging and its Translation to Medicine, Währinger Gürtel 18-20, 1090 Vienna, Austria.
authors: Rainer A
authors: RA
authors: Leitgeb
keywords: (140.3600) Lasers, tunable; (170.0110) Imaging systems; (170.3880) Medical and biological imaging; (170.4500) Optical coherence tomography; (170.4580) Optical diagnostics for medicine