title: Sjögren's syndrome: from pathogenesis to novel therapeutic targets.
abstract: Primary Sjögren's syndrome (pSS) is a chronic inflammatory autoimmune disease, characterised by a chronic infiltration of exocrine glands, mainly salivary glands, with the histological features of focal lymphocytic sialoadenitis. Disease spectrum is broad and the occurrence of several extra-glandular manifestations, and in rare cases lymphoma development, is well known. A specific approved treatment for pSS is still lacking and the detection of novel therapeutic biologic target is ongoing. The identification of biological fingerprints seems essential in order to stratify patients both in clinical trials and in real life. Discovery of new components of the inflammatory response will be the key in the future for the identification of novel additional therapeutic options.
authors: Centre for Translational Inflammation Research, Institute of Inflammation and Ageing, University of Birmingham, UK. f.barone@bham.ac.uk.
authors: Francesca
authors: F
authors: Barone
authors: Centre for Translational In ammation Research, Institute of In ammation and Ageing, University of Birmingham, UK; and Department of Internal Medicine and Medical Specialties, Rheumatology Unit, Sapienza University of Rome, Italy.
authors: Serena
authors: S
authors: Colafrancesco
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D015551:Autoimmunity / Q000187:drug effects; D016207:Cytokines / Q000037:antagonists & inhibitors* / Q000276:immunology / Q000378:metabolism; D006801:Humans; D018836:Inflammation Mediators / Q000037:antagonists & inhibitors* / Q000276:immunology / Q000378:metabolism; D058990:Molecular Targeted Therapy; D015398:Signal Transduction / Q000187:drug effects; D012859:Sjogren's Syndrome / Q000188:drug therapy* / Q000276:immunology / Q000378:metabolism; D017154:Stromal Cells / Q000187:drug effects / Q000276:immunology; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology
chemical_list: D000893:Anti-Inflammatory Agents; D016207:Cytokines; D018836:Inflammation Mediators