title: Proliferating cell nuclear antigen in neutrophil fate.
abstract: The life span of a neutrophil is a tightly regulated process as extended survival is beneficial for pathogen elimination and cell death necessary to prevent cytotoxic content release from activated neutrophils at the inflammatory site. Therefore, the control between survival and death must be a dynamic process. We have previously described that proliferating cell nuclear antigen (PCNA) which is known as a nuclear protein pivotal in DNA synthesis, is a key element in controlling neutrophil survival through its association with procaspases. Contrary to the dogma which asserted that PCNA has a strictly nuclear function, in mature neutrophils, PCNA is present exclusively within the cytosol due to its nuclear export at the end of the granulocytic differentiation. More recent studies are consistent with the notion that the cytosolic scaffold of PCNA is aimed at modulating neutrophil fate rather than simply preventing death. Ultimately, targeting neutrophil survival might have important applications not just in the field of immunology and inflammation, but also in hematology and transfusion. The neutrophil emerges as a unique and powerful cellular model to unravel the basic mechanisms governing the cell cycle-independent functions of PCNA and should be considered as a leader of the pack.
authors: INSERM U1016, Paris, France.|Institut Cochin, Faculté de Médecine Sorbonne Paris Cité, Université Paris Descartes, Paris, France.|CNRS UMR 8104, Paris, France.|Center of Excellence, Labex Inflamex, Paris, France.
authors: Véronique
authors: V
authors: Witko-Sarsat
authors: INSERM U1016, Paris, France.|Institut Cochin, Faculté de Médecine Sorbonne Paris Cité, Université Paris Descartes, Paris, France.|CNRS UMR 8104, Paris, France.|Center of Excellence, Labex Inflamex, Paris, France.
authors: Delphine
authors: D
authors: Ohayon
mesh_terms: D000818:Animals; D017209:Apoptosis; D053471:Caspases, Initiator / Q000378:metabolism; D015550:Cell Degranulation; D002470:Cell Survival; D006801:Humans; D018375:Neutrophil Activation; D009504:Neutrophils / Q000276:immunology*; D018809:Proliferating Cell Nuclear Antigen / Q000378:metabolism*; D021381:Protein Transport
chemical_list: D018809:Proliferating Cell Nuclear Antigen; D053471:Caspases, Initiator
keywords: apoptosis; cell death; nuclear export