title: DNA methylation and leukemia susceptibility in China: Evidence from an updated meta-analysis.
abstract: Mounting evidence supports a role for DNA methylation in the pathogenesis of leukemia; however, there no overview of these results in the Chinese population. The present study performed a comprehensive meta-analysis to establish candidate genes with an altered methylation status in Chinese leukemia patients. Eligible studies were identified through searching the National Center of Biotechnology Information PubMed and Wanfang databases. Studies were pooled and overall odds ratios with corresponding confidence intervals were calculated. A total of 4,325 leukemia patients and 2,010 controls from 94 studies on 53 genes were included in this meta-analysis, and 47 genes were found to be aberrantly methylated in leukemia patients. A further subgroup meta-analysis by leukemia subtype demonstrated that hypermethylation of 5 genes, namely cyclin-dependent kinase (CDKN)2A, DNA-binding protein inhibitor-4,CDKN2B, glioma pathogenesis-related protein 1 andp73, contributed to the risk of various subtypes of leukemia. In addition, a strong association betweenCDKN2Aand leukemia was identified in Chinese (P<0.00001) but not in European patients. The aberrantly methylated genes identified in the present meta-analysis may help elucidate the mechanisms underlying the development of leukemia in Chinese patients.
authors: Medical Genetics Center, School of Medicine, Ningbo University, Ningbo, Zhejiang 315211, P.R. China.
authors: Danjie
authors: D
authors: Jiang
authors: Medical Genetics Center, School of Medicine, Ningbo University, Ningbo, Zhejiang 315211, P.R. China.
authors: Yirun
authors: Y
authors: Li
authors: Medical Genetics Center, School of Medicine, Ningbo University, Ningbo, Zhejiang 315211, P.R. China.
authors: Qingxiao
authors: Q
authors: Hong
authors: Medical Genetics Center, School of Medicine, Ningbo University, Ningbo, Zhejiang 315211, P.R. China.
authors: Yusheng
authors: Y
authors: Shen
authors: Medical Genetics Center, School of Medicine, Ningbo University, Ningbo, Zhejiang 315211, P.R. China.
authors: Chunjing
authors: C
authors: Xu
authors: Medical Genetics Center, School of Medicine, Ningbo University, Ningbo, Zhejiang 315211, P.R. China.
authors: Yan
authors: Y
authors: Xu
authors: Medical Genetics Center, School of Medicine, Ningbo University, Ningbo, Zhejiang 315211, P.R. China.
authors: Huangkai
authors: H
authors: Zhu
authors: Medical Genetics Center, School of Medicine, Ningbo University, Ningbo, Zhejiang 315211, P.R. China.
authors: Dongjun
authors: D
authors: Dai
authors: Department of Hematology, Ningbo First Hospital, Ningbo, Zhejiang 315010, P.R. China.
authors: Guifang
authors: G
authors: Ouyang
authors: Medical Genetics Center, School of Medicine, Ningbo University, Ningbo, Zhejiang 315211, P.R. China.
authors: Shiwei
authors: S
authors: Duan
keywords: Chinese population; DNA methylation; epigenetics; ethnic difference; leukemia