title: New macrocyclic lactones with acaricidal and nematocidal activities from a genetically engineered strain Streptomyces bingchenggensis BCJ60.
abstract: Two new macrocyclic lactones, 4,25-diethyl-4,25-demethyl-milbemycin β3(1) and 27-formaldehyde-milbemycin β14(2), were isolated from a genetically engineered strain Streptomyces bingchenggensis BCJ60. Their structures were determined on the basis of spectroscopic analysis, including 1D and 2D NMR techniques as well as ESI-MS and comparison with data from the literature. The acaricidal and nematocidal capacities of compounds 1 and 2 were evaluated against Tetranychus cinnabarinus and Bursaphelenchus xylophilus, respectively. The results showed that the two new macrocyclic lactones 1 and 2 possessed potent acaricidal and nematocidal activities.
authors: a Life Science and Biotechnology Research Center , School of Life Science, Northeast Agricultural University , Harbin 150030 , China.
authors: Jian-Song
authors: JS
authors: Li
authors: c Department of New Drug Screening , Zhejiang Hisun Pharmaceutical Co., Ltd , Taizhou 318000 , China.
authors: Hui
authors: H
authors: Zhang
authors: b Provincial Joint Engineering Laboratory of Biopesticide Preparation, School of Forestry & Biotechnology , Zhejiang Agricultural and Forestry University , Lin'An 311300 , China.
authors: Shao-Yong
authors: SY
authors: Zhang
authors: a Life Science and Biotechnology Research Center , School of Life Science, Northeast Agricultural University , Harbin 150030 , China.
authors: Hai-Yan
authors: HY
authors: Wang
authors: a Life Science and Biotechnology Research Center , School of Life Science, Northeast Agricultural University , Harbin 150030 , China.
authors: Ji
authors: J
authors: Zhang
authors: b Provincial Joint Engineering Laboratory of Biopesticide Preparation, School of Forestry & Biotechnology , Zhejiang Agricultural and Forestry University , Lin'An 311300 , China.
authors: An-Liang
authors: AL
authors: Chen
authors: b Provincial Joint Engineering Laboratory of Biopesticide Preparation, School of Forestry & Biotechnology , Zhejiang Agricultural and Forestry University , Lin'An 311300 , China.|c Department of New Drug Screening , Zhejiang Hisun Pharmaceutical Co., Ltd , Taizhou 318000 , China.
authors: Ji-Dong
authors: JD
authors: Wang
authors: a Life Science and Biotechnology Research Center , School of Life Science, Northeast Agricultural University , Harbin 150030 , China.
authors: Wen-Sheng
authors: WS
authors: Xiang
mesh_terms: D056810:Acaricides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D000818:Animals; D000969:Antinematodal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D005818:Genetic Engineering; D007783:Lactones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D018942:Macrolides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D015394:Molecular Structure; D013302:Streptomyces / Q000737:chemistry* / Q000235:genetics*; D040102:Tetranychidae
chemical_list: C000616994:27-formaldehyde-milbemycin beta14; C000616993:4,25-diethyl-4,25-demethyl-milbemycin beta3; D056810:Acaricides; D000969:Antinematodal Agents; D007783:Lactones; D018942:Macrolides; C027837:moxidectin
keywords: New macrocyclic lactones; Streptomyces bingchenggensis BCJ60; acaricidal and nematocidal activities; genetically engineered strain