title: Validation of the Memorial Sloan Kettering Cancer Center nomogram to predict disease-specific survival in a Chinese gastric cancer population receiving postoperative chemoradiotherapy after an R0 resection.
abstract: The widely validated Memorial Sloan Kettering Cancer Center (MSKCC) nomogram for gastric carcinoma (GC) was developed based on patients who received R0 resection only. The purpose of the current study was to assess the performance of this nomogram in Chinese patients who received postoperative chemoradiotherapy (CRT) after an R0 resection for GC. From 2006 to 2015, the clinical data of 150 eligible patients were retrospectively collected from the Fudan University Shanghai Cancer Center (FUSCC) and used for external validation. The nomogram was validated by means of the concordance index (CI) and a calibration plot. The CI for the nomogram was 0.657, which was lower than the CI of the nomogram for patients who received surgery alone (0.80). In the calibration plot, the gap between the observed and the predicted survival gradually increased as the predicted 5-year disease-specific survival (DSS) decreased. Thus the MSKCC nomogram for GC significantly underestimated the survival of patients in the FUSCC cohort, especially the survival of patients whose predicted 5-year DSS was less than 50%. The current study indicates the potential for the nomogram to be developed as an ideal tool to identify target patients for postoperative CRT.
authors: Department of Radiation Oncology, Fudan University Shanghai Cancer Center, Shanghai, 200032, PR China.|Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, 200032, PR China.
authors: Meng-Long
authors: ML
authors: Zhou
authors: Department of Pathology, Fudan University Shanghai Cancer Center, Shanghai, 200032, PR China.|Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, 200032, PR China.
authors: Lei
authors: L
authors: Wang
authors: Department of Radiation Oncology, Fudan University Shanghai Cancer Center, Shanghai, 200032, PR China.|Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, 200032, PR China.
authors: Jia-Zhou
authors: JZ
authors: Wang
authors: Department of Radiation Oncology, Fudan University Shanghai Cancer Center, Shanghai, 200032, PR China.|Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, 200032, PR China.
authors: Wang
authors: W
authors: Yang
authors: Department of Radiation Oncology, Fudan University Shanghai Cancer Center, Shanghai, 200032, PR China.|Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, 200032, PR China.
authors: Ran
authors: R
authors: Hu
authors: Department of Radiation Oncology, Fudan University Shanghai Cancer Center, Shanghai, 200032, PR China.|Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, 200032, PR China.
authors: Gui-Chao
authors: GC
authors: Li
authors: Department of Pathology, Fudan University Shanghai Cancer Center, Shanghai, 200032, PR China.|Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, 200032, PR China.
authors: Wei-Qi
authors: WQ
authors: Sheng
authors: Department of Radiation Oncology, Fudan University Shanghai Cancer Center, Shanghai, 200032, PR China.|Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, 200032, PR China.
authors: Zhen
authors: Z
authors: Zhang
mesh_terms: D000328:Adult; D000368:Aged; D059248:Chemoradiotherapy; D002681:China / Q000453:epidemiology; D015331:Cohort Studies; D005260:Female; D005500:Follow-Up Studies; D005743:Gastrectomy; D006801:Humans; D008297:Male; D008875:Middle Aged; D049451:Nomograms; D018579:Patient Selection; D011184:Postoperative Period; D011379:Prognosis; D012189:Retrospective Studies; D013274:Stomach Neoplasms / Q000175:diagnosis / Q000453:epidemiology* / Q000401:mortality; D016019:Survival Analysis
keywords: gastric carcinoma; nomogram; patient selection; postoperative chemoradiation; prognosis