title: Origin of oligodendrocytes in mammalian forebrains: a revised perspective.
abstract: Oligodendrocyte precursor cells (OPCs) appear in the late embryonic brain, mature into oligodendrocytes (OLs), and form myelin in the postnatal brain. It has been proposed that early born OPCs derived from the ventral forebrain are eliminated postnatally and late-born OLs predominate in the adult mouse cortex. However, the temporal and regional niche for cortical OL generation, which persists throughout life in adult mammals, remains to be determined. Our recent study provides new insight into self-renewing and multipotent neural stem cells (NSCs). Our results, together with previous studies, suggest that NSCs at the dorsoventral boundary are uniquely specialized to produce myelin-forming OLs in the cortex during a restricted temporal window. These findings may help identify transcription factors or gene expression patterns which confer neural precursors with the characteristic ability of dorsoventral boundary NSCs to differentiate into OLs, and facilitate the development of new strategies for regenerative medicine of the damaged brain.
authors: Division of Neurobiology and Bioinformatics, National Institute for Physiological Sciences, Okazaki, Japan.|Department of Molecular and Cellular Neurobiology, Gunma University Graduate School of Medicine, Maebashi, Japan.
authors: Masae
authors: M
authors: Naruse
authors: Department of Molecular and Cellular Neurobiology, Gunma University Graduate School of Medicine, Maebashi, Japan.
authors: Yasuki
authors: Y
authors: Ishizaki
authors: Division of Neurobiology and Bioinformatics, National Institute for Physiological Sciences, Okazaki, Japan.
authors: Kazuhiro
authors: K
authors: Ikenaka
authors: Department of Integrative Physiology, Shiga University of Medical Science, Otsu, Shiga, Japan.
authors: Aoi
authors: A
authors: Tanaka
authors: Division of Neurobiology and Bioinformatics, National Institute for Physiological Sciences, Okazaki, Japan. shitoshi-tky@umin.ac.jp.|Department of Integrative Physiology, Shiga University of Medical Science, Otsu, Shiga, Japan. shitoshi-tky@umin.ac.jp.
authors: Seiji
authors: http://orcid.org/0000-0002-6339-6802
authors: S
authors: Hitoshi
mesh_terms: D000818:Animals; D002454:Cell Differentiation / Q000502:physiology*; D002540:Cerebral Cortex / Q000166:cytology*; D006801:Humans; D058953:Neural Stem Cells / Q000166:cytology*; D009836:Oligodendroglia / Q000166:cytology*
keywords: Cortical oligodendrocyte; Dorsoventral boundary; FGF; Neural stem cells; Wnts