title: Peak-Finding Algorithms.
abstract: Microarray and next-generation sequencing technologies have greatly expedited the discovery of genomic DNA that can be enriched using various biochemical methods. Chromatin immunoprecipitation (ChIP) is a general method for enriching chromatin fragments that are specifically recognized by an antibody. The resulting DNA fragments can be assayed by microarray (ChIP-chip) or sequencing (ChIP-seq). This introduction focuses on ChIP-seq data analysis. The first step of analyzing ChIP-seq data is identifying regions in the genome that are enriched in a ChIP sample; these regions are called peaks.
authors: Jui-Hung
authors: JH
authors: Hung
authors: Zhiping
authors: Z
authors: Weng
mesh_terms: D000465:Algorithms; D047369:Chromatin Immunoprecipitation / Q000379:methods*; D019295:Computational Biology / Q000379:methods*; D001330:Electronic Data Processing; D046228:Microarray Analysis; D017422:Sequence Analysis, DNA