title: Biologically Inspired Polydopamine Capped Gold Nanorods for Drug Delivery and Light-Mediated Cancer Therapy.
abstract: Multifunctional drug delivery and combined multimodal therapy strategies are very promising in tumor theranostic applications. In this work, a simple and versatile nanoplatform based on biologically inspired polydopamine capped gold nanorods (GNR-PDA) is developed. Dopamine, a well-known neurotransmitter associated with many neuronal disorders, can undergo self-polymerization on the surface of GNRs to form a stable PDA shell. Its unique molecular adsorption property, as well as its high chemical stability and biocompatibility, facilitate GNR-PDA as an ideal candidate for drug delivery. Methylene blue (MB) and doxorubicin (DOX) are directly adsorbed on GNR-PDA via electrostatic and/or π-π stacking interactions, forming GNR-PDA-MB and GNR-PDA-DOX nanocomposites, respectively. The GNR-PDA-MB can generate reactive oxygen species (ROS, from MB) or hyperthermia (from GNR-PDA) with high efficiency under deep-red/NIR laser irradiation, while the GNR-PDA-DOX exhibits light-enhanced drug release under NIR laser irradiation. The combined dual-modal light-mediated therapy, by using GNR-PDA-MB [photodynamic/photothermal therapy (PDT/PTT)] and GNR-PDA-DOX (Chemo/PTT), is carried out and shows remarkable cancer cell killing efficiency in vitro and significant suppression of tumor growth in vivo, which are much more distinct than any single-modal therapy strategy. Our work illustrates that GNR-PDA could be a promising nanoplatform for multifunctional drug delivery and multimodal tumor theranostics in the future.
authors: State Key Laboratory of Modern Optical Instrumentations, Centre for Optical and Electromagnetic Research, and ‡Bioelectromagnetics Laboratory, School of Medicine, Zhejiang University , Hangzhou, Zhejiang 310058, China.
authors: Shaowei
authors: S
authors: Wang
authors: State Key Laboratory of Modern Optical Instrumentations, Centre for Optical and Electromagnetic Research, and ‡Bioelectromagnetics Laboratory, School of Medicine, Zhejiang University , Hangzhou, Zhejiang 310058, China.
authors: Xinyuan
authors: X
authors: Zhao
authors: State Key Laboratory of Modern Optical Instrumentations, Centre for Optical and Electromagnetic Research, and ‡Bioelectromagnetics Laboratory, School of Medicine, Zhejiang University , Hangzhou, Zhejiang 310058, China.
authors: Shaochuan
authors: S
authors: Wang
authors: State Key Laboratory of Modern Optical Instrumentations, Centre for Optical and Electromagnetic Research, and ‡Bioelectromagnetics Laboratory, School of Medicine, Zhejiang University , Hangzhou, Zhejiang 310058, China.
authors: Jun
authors: J
authors: Qian
authors: State Key Laboratory of Modern Optical Instrumentations, Centre for Optical and Electromagnetic Research, and ‡Bioelectromagnetics Laboratory, School of Medicine, Zhejiang University , Hangzhou, Zhejiang 310058, China.
authors: Sailing
authors: S
authors: He
mesh_terms: D045744:Cell Line, Tumor; D004317:Doxorubicin; D006046:Gold; D006801:Humans; D007211:Indoles; D043942:Nanotubes; D010789:Phototherapy; D011108:Polymers
chemical_list: D007211:Indoles; D011108:Polymers; C568283:polydopamine; D006046:Gold; D004317:Doxorubicin
keywords: chemotherapy; drug delivery; gold nanorods; light-mediated therapy; photodynamic; photothermal; polydopamine