title: Extracellular Vesicles as New Players in Cellular Senescence.
abstract: Cell senescence is associated with the secretion of many factors, the so-called "senescence-associated secretory phenotype", which may alter tissue microenvironment, stimulating the organism to clean up senescent cells and replace them with newly divided ones. Therefore, although no longer dividing, these cells are still metabolically active and influence the surrounding tissue. Much attention has been recently focused not only on soluble factors released by senescent cells, but also on extracellular vesicles as conveyors of senescence signals outside the cell. Here, we give an overview of the role of extracellular vesicles in biological processes and signaling pathways related to senescence and aging.
authors: Department of Chemistry, Biology and Biotechnology, University of Perugia, Via del Giochetto, 06123 Perugia, Italy. lorena.urbanelli@unipg.it.
authors: Lorena
authors: L
authors: Urbanelli
authors: Department of Chemistry, Biology and Biotechnology, University of Perugia, Via del Giochetto, 06123 Perugia, Italy. sandra.buratta@unipg.it.
authors: Sandra
authors: S
authors: Buratta
authors: Department of Chemistry, Biology and Biotechnology, University of Perugia, Via del Giochetto, 06123 Perugia, Italy. krizia.sagini@studenti.unipg.it.
authors: Krizia
authors: K
authors: Sagini
authors: Department of Chemistry, Biology and Biotechnology, University of Perugia, Via del Giochetto, 06123 Perugia, Italy. brunella.tancini@unipg.it.
authors: Brunella
authors: B
authors: Tancini
authors: Department of Chemistry, Biology and Biotechnology, University of Perugia, Via del Giochetto, 06123 Perugia, Italy. carla.emiliani@unipg.it.|Centro di Eccellenza sui Materiali Innovativi Nanostrutturati (CEMIN), University of Perugia, Via Elce di Sotto 8, 06123 Perugia, Italy. carla.emiliani@unipg.it.
authors: Carla
authors: C
authors: Emiliani
mesh_terms: D000818:Animals; D016922:Cellular Senescence / Q000235:genetics / Q000502:physiology*; D055354:Exosomes / Q000378:metabolism; D000067128:Extracellular Vesicles / Q000378:metabolism*; D006801:Humans; D015398:Signal Transduction / Q000235:genetics / Q000502:physiology
keywords: aging; ectosomes; exosomes; extracellular vesicles; microvesicles; senescence; senescence-associated secretory phenotype (SASP)