title: A Randomized Clinical Trial of Comparing Monophasic Monodensified and Biphasic Nonanimal Stabilized Hyaluronic Acid Dermal Fillers in Treatment of Asian Nasolabial Folds.
abstract: BACKGROUND
  Cross-linked hyaluronic acids (HAs) with varying characteristics and formulations are available. Despite the popularity of HA, limited studies compared the effectiveness of monophasic monodensified hyaluronic acid (MMHA) and biphasic nonanimal stabilized hyaluronic acid (BHA) products in correcting nasolabial folds (NLFs) in the Asian population.
  
  
  OBJECTIVE
  This double-blinded, randomized research aimed at evaluating the outcomes of MMHA and BHA products in treating Asian NLFs.
  
  
  METHODS
  Subjects aged between 18 and 65 years with moderate-to-severe NLFs were randomized to receive MMHA or BHA treatment. A touch-up treatment with the same product was performed at the 4-week follow-up, if needed. The effectiveness was evaluated for 24 weeks by masked investigators. All adverse events were recorded for safety evaluation.
  
  
  RESULTS
  Twenty-five subjects in the MMHA Group and twenty-four subjects in the BHA Group finished 24-week follow-up. Results showed that subjects from both groups obtained satisfactory outcome in NLF correction. A lower amount of MMHA was required to achieve a similar result as that of BHA (p < .01). Both HA products maintained the effectiveness at the end of the 24-week follow-up.
  
  
  CONCLUSIONS
  Both MMHA and BHA are effective for correcting NLF in Asian patients, producing satisfactory results. Monophasic monodensified hyaluronic acid provides similar satisfaction to BHA while requiring less injection volume.
authors: *All the authors are affiliated with the Department of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University, Shanghai, China.
authors: Shuang-Bai
authors: SB
authors: Zhou
authors: Yun
authors: Y
authors: Xie
authors: Cheng-An
authors: CA
authors: Chiang
authors: Kai
authors: K
authors: Liu
authors: Qing-Feng
authors: QF
authors: Li
mesh_terms: D000328:Adult; D044466:Asian People; D003357:Cosmetic Techniques; D000067548:Dermal Fillers / Q000009:adverse effects / Q000737:chemistry* / Q000627:therapeutic use*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D006820:Hyaluronic Acid / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D060052:Nasolabial Fold; D015595:Skin Aging
chemical_list: D000067548:Dermal Fillers; C000617181:matrifill; D006820:Hyaluronic Acid; C445361:Restylane