title: Feed contamination with Fusarium mycotoxins induces a corticosterone stress response in broiler chickens.
abstract: The aim of the present study was to evaluate the effect of the Fusarium mycotoxins deoxynivalenol (DON) and fumonisins (FBs) on the stress response in broiler chickens, using corticosterone (CORT) in plasma as a biomarker. Chickens were fed either a control diet, a DON contaminated diet, a FBs contaminated diet, or a DON and FBs contaminated diet for 15 d at concentrations close to the European Union maximum guidance levels for DON and FBs in poultry. Mean plasma CORT levels were significantly higher in broiler chickens fed a DON contaminated and a DON and FBs contaminated diet compared to birds fed a control diet. A similar trend was observed for animals fed a FBs contaminated diet. Consequently, feeding broilers a diet contaminated with DON and/or FBs induced a CORT stress response, which may indicate a negative effect on animal welfare.
authors: Department of Pharmacology, Toxicology and Biochemistry, Faculty of Veterinary Medicine, Ghent University, 9820 Merelbeke, Belgium Gunther.Antonissen@UGent.be.|Department of Pathology, Bacteriology and Avian Diseases, Faculty of Veterinary Medicine, Ghent University, 9820 Merelbeke, Belgium.
authors: G
authors: G
authors: Antonissen
authors: Department of Pharmacology, Toxicology and Biochemistry, Faculty of Veterinary Medicine, Ghent University, 9820 Merelbeke, Belgium.
authors: S
authors: S
authors: De Baere
authors: Department of Pharmacology, Toxicology and Biochemistry, Faculty of Veterinary Medicine, Ghent University, 9820 Merelbeke, Belgium.
authors: M
authors: M
authors: Devreese
authors: Department of Pathology, Bacteriology and Avian Diseases, Faculty of Veterinary Medicine, Ghent University, 9820 Merelbeke, Belgium.
authors: F
authors: F
authors: Van Immerseel
authors: Department of Pathology, Bacteriology and Avian Diseases, Faculty of Veterinary Medicine, Ghent University, 9820 Merelbeke, Belgium.
authors: A
authors: A
authors: Martel
authors: Department of Pharmacology, Toxicology and Biochemistry, Faculty of Veterinary Medicine, Ghent University, 9820 Merelbeke, Belgium.
authors: S
authors: S
authors: Croubels
mesh_terms: D000821:Animal Feed / Q000032:analysis; D000818:Animals; D015415:Biomarkers / Q000097:blood; D002645:Chickens / Q000502:physiology*; D003345:Corticosterone / Q000097:blood*; D005260:Female; D005516:Food Microbiology; D037341:Fumonisins / Q000633:toxicity; D005670:Fusarium / Q000737:chemistry*; D008297:Male; D009183:Mycotoxins / Q000633:toxicity*; D013312:Stress, Physiological / Q000187:drug effects*; D014255:Trichothecenes / Q000633:toxicity
chemical_list: D015415:Biomarkers; D037341:Fumonisins; D009183:Mycotoxins; D014255:Trichothecenes; C007262:deoxynivalenol; D003345:Corticosterone
keywords: broiler chickens; corticosterone; deoxynivalenol; fumonisins; mycotoxins