title: Development of a Risk Score to Predict Detection of Metastasized or Locally Advanced Perihilar Cholangiocarcinoma at Staging Laparoscopy.
abstract: Nearly half of patients with perihilar cholangiocarcinoma (PHC) have incurable tumors at laparotomy. Staging laparoscopy (SL) potentially detects metastases or locally advanced disease, thereby avoiding unnecessary laparotomy. However, the diagnostic yield of SL has decreased with improved imaging in recent years.
  
  
  
  The aim of this study was to identify predictors for detecting metastasized or locally advanced PHC at SL and to develop a risk score to select patients who may benefit most from this procedure.
  
  
  
  Data of patients with potentially resectable PHC who underwent SL between 2000 and 2015 in our center were retrospectively analyzed. Multivariable logistic regression analysis was used to identify independent predictors and to develop a preoperative risk score.
  
  
  
  Unresectable PHC was detected in 41 of 273 patients undergoing SL (yield 15 %). Overall sensitivity of SL was 30 %, with highest sensitivity for detecting peritoneal metastases (73 %). Preoperative imaging factors that were independently associated with unresectability at SL were tumor size ≥4.5 cm, bilateral portal vein involvement, suspected lymph node metastases, and suspected (extra)hepatic metastases on imaging without the possibility of diagnosis by percutaneous- or endoscopic ultrasound-guided biopsy. The derived preoperative risk score showed good discrimination to predict unresectability (area under the curve 0.77, 95 % confidence interval 0.68-0.86) and identified three subgroups with a predicted low-risk of 7 % (N = 203 patients), intermediate-risk of 21 % (N = 39), and high-risk of 58 % (N = 31).
  
  
  
  A selective approach for SL in PHC is recommended since the overall yield is low. The proposed preoperative risk score is useful in selecting patients for SL.
authors: Department of Surgery, Academic Medical Center, Amsterdam, The Netherlands. r.j.coelen@amc.nl.
authors: Robert J S
authors: RJ
authors: Coelen
authors: Department of Surgery, Academic Medical Center, Amsterdam, The Netherlands.
authors: Anthony T
authors: AT
authors: Ruys
authors: Department of Surgery, Academic Medical Center, Amsterdam, The Netherlands.
authors: Jimme K
authors: JK
authors: Wiggers
authors: Department of Radiology, Academic Medical Center, Amsterdam, The Netherlands.
authors: Chung Y
authors: CY
authors: Nio
authors: Department of Pathology, Academic Medical Center, Amsterdam, The Netherlands.
authors: Joanne
authors: J
authors: Verheij
authors: Department of Surgery, Academic Medical Center, Amsterdam, The Netherlands.
authors: Dirk J
authors: DJ
authors: Gouma
authors: Department of Surgery, Academic Medical Center, Amsterdam, The Netherlands.
authors: Marc G H
authors: MG
authors: Besselink
authors: Department of Surgery, Academic Medical Center, Amsterdam, The Netherlands.
authors: Olivier R C
authors: OR
authors: Busch
authors: Department of Surgery, Academic Medical Center, Amsterdam, The Netherlands.
authors: Thomas M
authors: TM
authors: van Gulik
mesh_terms: D000368:Aged; D001650:Bile Duct Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery*; D018281:Cholangiocarcinoma / Q000000981:diagnostic imaging / Q000556:secondary* / Q000601:surgery*; D000075204:Contraindications, Procedure; D006801:Humans; D010535:Laparoscopy; D008113:Liver Neoplasms / Q000175:diagnosis* / Q000556:secondary; D008207:Lymphatic Metastasis; D008875:Middle Aged; D009367:Neoplasm Staging; D010534:Peritoneal Neoplasms / Q000175:diagnosis* / Q000556:secondary; D011169:Portal Vein / Q000473:pathology; D011237:Predictive Value of Tests; D018570:Risk Assessment / Q000379:methods; D047368:Tumor Burden