title: APOL1-Associated End-Stage Renal Disease in a Living Kidney Transplant Donor.
abstract: Homozygosity for apolipoprotein-L1 (APOL1) risk variants has emerged as an important predictor of renal disease in individuals of African descent over the past several years. Additionally, these risk variants may be important predictors of renal allograft failure when present in a living or deceased donor. Currently, there is no universal recommendation for screening of potential donors. We present a case of end-stage renal disease with focal segmental glomerulosclerosis in a living donor 7 years following donor nephrectomy. Genetic assessment revealed homozygosity for the G1 high-risk APOL1 variant.
authors: Comprehensive Transplant Center, Northwestern University Feinberg School of Medicine, Chicago, IL.|McGaw Medical Center of Northwestern University, Chicago, IL.
authors: N A
authors: NA
authors: Zwang
authors: Comprehensive Transplant Center, Northwestern University Feinberg School of Medicine, Chicago, IL.
authors: A
authors: A
authors: Shetty
authors: Comprehensive Transplant Center, Northwestern University Feinberg School of Medicine, Chicago, IL.
authors: N
authors: N
authors: Sustento-Reodica
authors: Comprehensive Transplant Center, Northwestern University Feinberg School of Medicine, Chicago, IL.|Center for Healthcare Studies, and Center for Bioethics and Medical Humanities, Northwestern University Feinberg School of Medicine, Chicago, IL.
authors: E J
authors: EJ
authors: Gordon
authors: Comprehensive Transplant Center, Northwestern University Feinberg School of Medicine, Chicago, IL.
authors: J
authors: J
authors: Leventhal
authors: Comprehensive Transplant Center, Northwestern University Feinberg School of Medicine, Chicago, IL.
authors: L
authors: L
authors: Gallon
authors: Comprehensive Transplant Center, Northwestern University Feinberg School of Medicine, Chicago, IL.
authors: J J
authors: 0000-0002-9344-9928
authors: JJ
authors: Friedewald
mesh_terms: D000328:Adult; D001741:Black or African American; D000075944:Apolipoprotein L1 / Q000235:genetics*; D015415:Biomarkers; D005260:Female; D014644:Genetic Variation; D005838:Genotype; D005919:Glomerular Filtration Rate; D006720:Homozygote; D006801:Humans; D007676:Kidney Failure, Chronic / Q000209:etiology* / Q000378:metabolism / Q000473:pathology; D007677:Kidney Function Tests; D016030:Kidney Transplantation / Q000009:adverse effects*; D019520:Living Donors; D011379:Prognosis; D012307:Risk Factors; D020858:Tissue and Organ Harvesting
chemical_list: C108666:APOL1 protein, human; D000075944:Apolipoprotein L1; D015415:Biomarkers
keywords: clinical research/practice; donor nephrectomy; donors and donation: donor follow-up; donors and donation: living; kidney transplantation/nephrology; organ transplantation in general; pathology/histopathology