title: Association of shift-work, daytime napping, and nighttime sleep with cancer incidence and cancer-caused mortality in Dongfeng-tongji cohort study.
abstract: Few studies investigated the combined effects of night-shift work, daytime napping, and nighttime sleep on cancer incidence and mortality.
  
  
  
  A total of 25,377 participants were included in this study. Information on sleep habits, cancer incidences, and mortalities were collected. Cox proportional hazards models were used to calculate the adjusted hazard ratios and 95% confidence intervals (HRs, 95%CIs).
  
  
  
  Male subjects experienced ≥20 years of night-shift work, or without daytime napping had an increased risk of cancer, when compared with males who did not have night-shift work or napped for 1-30 min [HR (95%CI) = 1.27 (1.01-1.59) and 2.03 (1.01-4.13), respectively]. Nighttime sleep for ≥10 h was associated with a separate 40% and 59% increased risk of cancer [HR (95%CI) = 1.40 (1.04-1.88)] and cancer-caused mortality [HR (95%CI) = 1.59 (1.01-2.49)] than sleep for 7-8 h/night. Combined effects of three sleep habits were further identified. Male participants with at least two above risk sleep habits had a 43% increased risk of cancer [HR (95%CI) = 1.43 (1.07-2.01)] and a 2.07-fold increased cancer-caused mortality [HR (95%CI) = 2.07 (1.25-3.29)] than those who did not have any above risk sleep habits. However, no significant associations were observed among women.
  
  
  
  Long night-shift work history, without daytime napping, and long nighttime sleep duration were independently and jointly associated with higher cancer incidence among males. KEY MESSAGES Night-shift work of ≥20 years, without napping, and nighttime sleep of ≥10 h were associated with increased cancer incidence. Nighttime sleep ≥10 h was associated with a 2.07-fold increased cancer-caused mortality among males. Combined effects of night-shift work ≥20 years, without napping, and nighttime sleep ≥10 h on increasing cancer incidence were existed among males.
authors: a Department of Occupational and Environmental Health, State Key Laboratory of Environmental Health (Incubating), School of Public Health , Tongji Medical College, Huazhong University of Science and Technology , Wuhan , China.
authors: Yansen
authors: Y
authors: Bai
authors: a Department of Occupational and Environmental Health, State Key Laboratory of Environmental Health (Incubating), School of Public Health , Tongji Medical College, Huazhong University of Science and Technology , Wuhan , China.
authors: Xiaoliang
authors: X
authors: Li
authors: a Department of Occupational and Environmental Health, State Key Laboratory of Environmental Health (Incubating), School of Public Health , Tongji Medical College, Huazhong University of Science and Technology , Wuhan , China.
authors: Ke
authors: K
authors: Wang
authors: a Department of Occupational and Environmental Health, State Key Laboratory of Environmental Health (Incubating), School of Public Health , Tongji Medical College, Huazhong University of Science and Technology , Wuhan , China.
authors: Shi
authors: S
authors: Chen
authors: a Department of Occupational and Environmental Health, State Key Laboratory of Environmental Health (Incubating), School of Public Health , Tongji Medical College, Huazhong University of Science and Technology , Wuhan , China.
authors: Suhan
authors: S
authors: Wang
authors: a Department of Occupational and Environmental Health, State Key Laboratory of Environmental Health (Incubating), School of Public Health , Tongji Medical College, Huazhong University of Science and Technology , Wuhan , China.
authors: Zhuowang
authors: Z
authors: Chen
authors: a Department of Occupational and Environmental Health, State Key Laboratory of Environmental Health (Incubating), School of Public Health , Tongji Medical College, Huazhong University of Science and Technology , Wuhan , China.
authors: Xiulong
authors: X
authors: Wu
authors: a Department of Occupational and Environmental Health, State Key Laboratory of Environmental Health (Incubating), School of Public Health , Tongji Medical College, Huazhong University of Science and Technology , Wuhan , China.
authors: Wenshan
authors: W
authors: Fu
authors: a Department of Occupational and Environmental Health, State Key Laboratory of Environmental Health (Incubating), School of Public Health , Tongji Medical College, Huazhong University of Science and Technology , Wuhan , China.
authors: Sheng
authors: S
authors: Wei
authors: a Department of Occupational and Environmental Health, State Key Laboratory of Environmental Health (Incubating), School of Public Health , Tongji Medical College, Huazhong University of Science and Technology , Wuhan , China.
authors: Jing
authors: J
authors: Yuan
authors: a Department of Occupational and Environmental Health, State Key Laboratory of Environmental Health (Incubating), School of Public Health , Tongji Medical College, Huazhong University of Science and Technology , Wuhan , China.
authors: Ping
authors: P
authors: Yao
authors: a Department of Occupational and Environmental Health, State Key Laboratory of Environmental Health (Incubating), School of Public Health , Tongji Medical College, Huazhong University of Science and Technology , Wuhan , China.
authors: Xiaoping
authors: X
authors: Miao
authors: a Department of Occupational and Environmental Health, State Key Laboratory of Environmental Health (Incubating), School of Public Health , Tongji Medical College, Huazhong University of Science and Technology , Wuhan , China.
authors: Xiaomin
authors: X
authors: Zhang
authors: a Department of Occupational and Environmental Health, State Key Laboratory of Environmental Health (Incubating), School of Public Health , Tongji Medical College, Huazhong University of Science and Technology , Wuhan , China.
authors: Meian
authors: M
authors: He
authors: b Dongfeng Central Hospital, Dongfeng Motor Corporation and Hubei University of Medicine , Shiyan , Hubei , China.
authors: Handong
authors: H
authors: Yang
authors: a Department of Occupational and Environmental Health, State Key Laboratory of Environmental Health (Incubating), School of Public Health , Tongji Medical College, Huazhong University of Science and Technology , Wuhan , China.
authors: Tangchun
authors: T
authors: Wu
authors: a Department of Occupational and Environmental Health, State Key Laboratory of Environmental Health (Incubating), School of Public Health , Tongji Medical College, Huazhong University of Science and Technology , Wuhan , China.
authors: Huan
authors: H
authors: Guo
mesh_terms: D000368:Aged; D002681:China / Q000453:epidemiology; D015331:Cohort Studies; D005260:Female; D006801:Humans; D015994:Incidence; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000453:epidemiology* / Q000401:mortality; D012307:Risk Factors; D012890:Sleep / Q000502:physiology*; D014940:Work Schedule Tolerance
keywords: Night-shift work; cancer incidence; cancer-caused mortality; daytime napping; nighttime sleep