title: Unified Total Synthesis of Five Gelsedine-Type Alkaloids: (-)-Gelsenicine, (-)-Gelsedine, (-)-Gelsedilam, (-)-14-Hydroxygelsenicine, and (-)-14,15-Dihydroxygelsenicine.
abstract: The systematic arrangement of a two-carbon unit, hydrogen atom, and oxygen atom on the versatile enal moiety of a non-natural synthetic intermediate successfully led to the unified access to the gelsedine-type alkaloids. The development and use of this new synthetic hub and an array of site-selective transformations resulted in the asymmetric synthesis of (-)-gelsenicine, (-)-gelsedine, (-)-gelsedilam, (-)-14-hydroxygelsenicine, and (-)-14,15-dihydroxygelsenicine.
authors: Graduate School of Pharmaceutical Sciences, University of Tokyo , 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.
authors: Takaaki
authors: T
authors: Harada
authors: Graduate School of Pharmaceutical Sciences, Nagoya University , Furo-cho, Chikusa, Nagoya, Aichi 464-8601, Japan.
authors: Jun
authors: J
authors: Shimokawa
authors: Graduate School of Pharmaceutical Sciences, Nagoya University , Furo-cho, Chikusa, Nagoya, Aichi 464-8601, Japan.
authors: Tohru
authors: T
authors: Fukuyama