title: Oral Lactobacillus rhamnosus GR-1 and Lactobacillus reuteri RC-14 to reduce Group B Streptococcus colonization in pregnant women: A randomized controlled trial.
abstract: OBJECTIVE
  This study is to examine the effect of Lactobacillus rhamnosus GR-1 and Lactobacillus reuteri RC-14 taken orally before bedtime on Group B Streptococcus (GBS)-positive pregnant women with respect to becoming GBS negative.
  
  
  METHODS
  In total, 110 pregnant women at 35-37 weeks of gestation who were diagnosed by GBS culture as being GBS positive for both vaginal and rectal GBS colonization were randomly assigned to be orally treated with two placebo capsules or two probiotic capsules (containing L. rhamnosus GR-1 and L. reuteri RC-14) before bedtime until delivery. All women were tested for vaginal and rectal GBS colonization again by GBS culture on admission for delivery.
  
  
  RESULTS
  Of the 110 participants, 99 completed the study (49 in the probiotic group and 50 in the placebo group). The GBS colonization results changed from positive to negative in 21 women in the probiotic group (42.9%) and in nine women in the placebo group (18.0%) during this period (Chi-square p=0.007).
  
  
  CONCLUSIONS
  Oral probiotic containing L. rhamnosus GR-1 and L. reuteri RC-14 could reduce the vaginal and rectal GBS colonization rate in pregnant women.
authors: Department of Obstetrics and Gynecology, China Medical University Hospital, China Medical University, Taichung 40402, Taiwan.
authors: Ming
authors: M
authors: Ho
authors: Department of Obstetrics and Gynecology, China Medical University Hospital, China Medical University, Taichung 40402, Taiwan.
authors: Yin-Yi
authors: YY
authors: Chang
authors: Department of Obstetrics and Gynecology, China Medical University Hospital, China Medical University, Taichung 40402, Taiwan.
authors: Wei-Chun
authors: WC
authors: Chang
authors: Department of Pediatrics, China Medical University Hospital, China Medical University, Taichung 40402, Taiwan.
authors: Hung-Chih
authors: HC
authors: Lin
authors: Department of Obstetrics and Gynecology, China Medical University Hospital, China Medical University, Taichung 40402, Taiwan.
authors: Mei-Hung
authors: MH
authors: Wang
authors: Department of Obstetrics and Gynecology, China Medical University Hospital, China Medical University, Taichung 40402, Taiwan.
authors: Wu-Chou
authors: WC
authors: Lin
authors: Department of Obstetrics and Gynecology, China Medical University Hospital, China Medical University, Taichung 40402, Taiwan. Electronic address: d4798@mail.cmuh.org.tw.
authors: Tsan-Hung
authors: TH
authors: Chiu
mesh_terms: D000328:Adult; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D018445:Infectious Disease Transmission, Vertical / Q000517:prevention & control; D052200:Limosilactobacillus reuteri; D052201:Lacticaseibacillus rhamnosus; D011247:Pregnancy; D011263:Pregnancy Trimester, Third; D019936:Probiotics / Q000627:therapeutic use*; D011446:Prospective Studies; D012007:Rectum / Q000382:microbiology; D013290:Streptococcal Infections / Q000382:microbiology / Q000517:prevention & control / Q000635:transmission; D013292:Streptococcus agalactiae / Q000254:growth & development*; D014621:Vagina / Q000382:microbiology
keywords: GBS colonization; GBS infection; intrapartum antibiotic; oral probiotics