title: Micronome revealed miR-19a/b as key regulator of SOCS3 during cancer related inflammation of oral squamous cell carcinoma.
abstract: Although significant advances have been established in molecular biology of Oral squamous cell carcinoma (OSCC), innovative strategies are still required to further understand detailed molecular mechanisms. Using bioinformatic approach, we aim to explore the potential miRNA-mRNA pairs in cancer related inflammatory response and investigate their potential roles as signature miRNA and proteins in the signaling pathway. Firstly, the differentially expressed genes of OSCC were selected which then underwent gene ontology to identify genes engaged in inflammatory response and its regulation. Validated miRNAs were retrieved and miRNAs with complete complementarily with their targets were visualized for miRNA-mRNA regulatory network. Protein-protein interactions of inflammatory and its regulatory genes were analyzed for interacting genes involved in signaling pathway. Eight universal miRNAs were obtained for inflammation and its regulation. miRNA-19a/b showed significant influence in controlling inflammatory response in OSCC. Therefore, micronome on deregulated genes in inflammation identifies miRNA-mRNA pairs which have high potential to be targeted for diagnostic and treatment applications in OSCC.
authors: Division of Clinical Research, University Centre of Excellence in Research, Baba Farid University of Health Science, Faridkot 151203, Punjab, India.
authors: Ajay Francis
authors: AF
authors: Christopher
authors: Division of Clinical Research, University Centre of Excellence in Research, Baba Farid University of Health Science, Faridkot 151203, Punjab, India.
authors: Mridula
authors: M
authors: Gupta
authors: Division of Clinical Research, University Centre of Excellence in Research, Baba Farid University of Health Science, Faridkot 151203, Punjab, India. Electronic address: bansal66@yahoo.com.
authors: Parveen
authors: P
authors: Bansal
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D007249:Inflammation / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D035683:MicroRNAs / Q000096:biosynthesis* / Q000235:genetics; D009062:Mouth Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D009363:Neoplasm Proteins / Q000096:biosynthesis* / Q000235:genetics; D012334:RNA, Neoplasm / Q000096:biosynthesis* / Q000235:genetics; D000071223:Suppressor of Cytokine Signaling 3 Protein / Q000096:biosynthesis* / Q000235:genetics
chemical_list: C549214:MIRN19A microRNA, human; D035683:MicroRNAs; D009363:Neoplasm Proteins; D012334:RNA, Neoplasm; C106644:SOCS3 protein, human; D000071223:Suppressor of Cytokine Signaling 3 Protein
keywords: Inflammation; Micronome; Oral squamous cell carcinoma; miRNA; miRNA-mRNA