title: HVPG signature: A prognostic and predictive tool in hepatocellular carcinoma.
abstract: Hepatic venous pressure gradient (HVPG) measurement provides independent prognostic value in patients with cirrhosis, and the prognostic and predictive role of HVPG in hepatocellular carcinoma (HCC) also has been explored. The management of HCC is limited to the European Association for the Study of the Liver (EASL) and American Association for the Study of Liver Diseases (AASLD) guidelines that consider that HVPG≥10 mmHg to be a contraindication for hepatic resection (HR), otherwise other treatment modalities are recommended. Current studies show that a raised HVPG diagnosed directly or indirectly leads to a negative prognosis of patients with HCC and cirrhosis, but HVPG greater than 10 mmHg should not be regarded as an absolute contraindication for HR. Selecting direct or surrogate measurement of HVPG is still under debate. Only several studies reported the impact of HVPG in negative prognosis of HCC patients after liver transplantation (LT) and the value of HVPG in the prediction of HCC development, which need to be further validated.
authors: Department of General Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, China.
authors: Xiaolong
authors: X
authors: Qi
authors: Department of Radiology, the Fourth People's Hospital of Huai'an, Huai'an, China.
authors: Xin
authors: X
authors: Zhang
authors: Department of General Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, China.
authors: Zhijia
authors: Z
authors: Li
authors: Department of General Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, China.
authors: Jialiang
authors: J
authors: Hui
authors: Department of General Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, China.
authors: Yi
authors: Y
authors: Xiang
authors: Department of Infectious Diseases, Nanfang Hospital, Southern Medical University, Guangzhou, China.
authors: Jinjun
authors: J
authors: Chen
authors: Department of Interventional Radiology, Nanfang Hospital, Southern Medical University, Guangzhou, China.
authors: Jianbo
authors: J
authors: Zhao
authors: Department of Gastroenterology, Tongji Hospital of Tongji University, Shanghai, China.
authors: Jing
authors: J
authors: Li
authors: Department of Hepatopancreatobiliary Surgery, Huai'an First People's Hospital, Nanjing Medical University, Huai'an, China.
authors: Fu-Zhen
authors: FZ
authors: Qi
authors: Department of Nephrology, The Affiliated Huai'an Hospital of Xuzhou Medical University and The Second People's Hospital of Huai'an, Huai'an, China.
authors: Yong
authors: Y
authors: Xu
mesh_terms: D006528:Carcinoma, Hepatocellular / Q000175:diagnosis* / Q000628:therapy; D006503:Hepatic Veins / Q000473:pathology*; D006801:Humans; D008099:Liver / Q000601:surgery; D008103:Liver Cirrhosis / Q000473:pathology; D008113:Liver Neoplasms / Q000175:diagnosis* / Q000628:therapy; D016031:Liver Transplantation; D010976:Platelet Count; D017410:Practice Guidelines as Topic; D011312:Pressure; D011379:Prognosis; D016896:Treatment Outcome
keywords: hepatic resection; hepatic venous pressure gradient; hepatocellular carcinoma; prediction; prognosis