title: [Combined Chemotherapy with Radiation was Tolerable and Effective Treatment in Female Octogenarian Patients with Urethral Cancer -Two Case Reports].
abstract: We report two octogenarian patients with primary urethral cancer treated with chemotherapy and external beam radiation therapy. An 85-year-old female presented with perineal bleeding. Magnetic resonance imaging (MRI) showed a locally advanced tumor in the urethra. Biopsy was performed and pathologic findings demonstrated squamous cell carcinoma. After receiving one cycle of a half dose of gemcitabine and nedaplatin, the patient received external beam radiation therapy with gemcitabine and nedaplatin treatment followed by two more cycles of chemotherapy. Complete response was achieved. An 87-year-old female presented with vaginal bleeding. MRIrevealed locally advanced urethral tumor with bilateral inguinal lymph node metastases. Scratch and urine cytology of tumor demonstrated squamous cell carcinoma. After the same treatment as in case 1, primary cancer and lymph node metastases were significantly decreased. There have been no signs of recurrence or progression after treatment, and no severe adverse events in either patient during 53 and 26 months'follow up, respectively.
authors: The Department of Urology, Kitasato University School of Medicine.
authors: Takashi
authors: T
authors: Tachibana
authors: The Department of Urology, Kitasato University School of Medicine.
authors: Kazumasa
authors: K
authors: Matsumoto
authors: The Department of Urology, Kitasato University School of Medicine.
authors: Shoji
authors: S
authors: Nagi
authors: The Department of Urology, Kitasato University School of Medicine.
authors: Masahiro
authors: M
authors: Hagiwara
authors: The Department of Urology, Kitasato University School of Medicine.
authors: Kentaro
authors: K
authors: Kobayashi
authors: The Department of Urology, Kitasato University School of Medicine.
authors: Hideyasu
authors: H
authors: Tsumura
authors: The Department of Urology, Kitasato University School of Medicine.
authors: Kazunari
authors: K
authors: Yoshida
authors: The Department of Urology, Kitasato University School of Medicine.
authors: Masatsugu
authors: M
authors: Iwamura
mesh_terms: D000369:Aged, 80 and over; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy* / Q000532:radiotherapy* / Q000556:secondary; D003131:Combined Modality Therapy; D003841:Deoxycytidine / Q000008:administration & dosage / Q000031:analogs & derivatives; D005260:Female; D006801:Humans; D008207:Lymphatic Metastasis; D008279:Magnetic Resonance Imaging; D009944:Organoplatinum Compounds / Q000008:administration & dosage; D061766:Proton Therapy; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome; D014523:Urethral Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000473:pathology / Q000532:radiotherapy*; D000093542:Gemcitabine
chemical_list: D009944:Organoplatinum Compounds; D003841:Deoxycytidine; C053989:nedaplatin; D000093542:Gemcitabine