title: Extinction theory & anorexia nervosa: Deepening therapeutic mechanisms.
abstract: By virtue of adopting the core symptomatic fear (i.e., a fear of weight gain) as a primary treatment target, the treatment of AN centrally involves exposure-driven processes. However, exposure trials targeting the fear of weight gain in AN have been sparse, yielding mixed results to date. In translating extinction theory to the treatment of AN, it is likely that the absence of a clear distinction between what constitutes the core feared cue and the core feared outcome has stymied the application of exposure treatments in AN. This review considers several configurations of the core fear association in AN, noting distinct therapeutic strategies which may allow for more precise efforts in violating fear-based expectancies. Specific guidance is offered in the clinical decision making process as to which strategies might best promote inhibitory learning, and a clinical case is discussed, in which treatment was adjusted to specifically violate the core underlying fear association.
authors: Department of Psychiatry, University of California, San Francisco, San Francisco, CA, USA. Electronic address: stuart.murray@ucsf.edu.
authors: Stuart B
authors: SB
authors: Murray
authors: Department of Psychology, University of California, Los Angeles, Los Angeles, CA, USA.
authors: Michael
authors: M
authors: Treanor
authors: Department of Psychiatry, University of California, San Diego, San Diego, CA, USA.
authors: Betty
authors: B
authors: Liao
authors: School of Psychology, Fairleigh Dickinson University, Teaneck, NJ, USA.
authors: Katharine L
authors: KL
authors: Loeb
authors: School of Psychology, University of Sydney, Sydney, NSW, Australia.
authors: Scott
authors: S
authors: Griffiths
authors: Department of Psychiatry, University of California, San Francisco, San Francisco, CA, USA.
authors: Daniel
authors: D
authors: Le Grange
mesh_terms: D000293:Adolescent; D000294:Adolescent Behavior / Q000523:psychology; D000856:Anorexia Nervosa / Q000628:therapy*; D005108:Extinction, Psychological; D005239:Fear / Q000523:psychology; D005260:Female; D006185:Habituation, Psychophysiologic; D006801:Humans; D007171:Implosive Therapy; D011582:Psychological Theory
keywords: Anorexia nervosa; Anxiety; Exposure treatment; Extinction learning; Fear conditioning