title: [DNA aptamers selection for breast cancer].
abstract: A method of selection of DNA aptamers to breast tumor tissue based on the use of postoperative material has been developed. Breast cancer tissues were used as the positive target; the negative targets included benign tumor tissue, adjacent healthy tissues, breast tissues from mastopathy patients, and also tissues of other types of malignant tumors. During selection a pool of DNA aptamers demonstrating selective binding to breast cancer cells and tissues and insignificant binding to breast benign tissues has been obtained. These DNA aptamers can be used for identification of protein markers, breast cancer diagnostics, and targeted delivery of anticancer drugs.
authors: Kirensky Institute of Physics, Krasnoyarsk, Russia; Voino-Yasenetski Krasnoyarsk State Medical University, Krasnoyarsk, Russia.
authors: G S
authors: GS
authors: Zamay
authors: Voino-Yasenetski Krasnoyarsk State Medical University, Krasnoyarsk, Russia.
authors: I V
authors: IV
authors: Belayanina
authors: Voino-Yasenetski Krasnoyarsk State Medical University, Krasnoyarsk, Russia.
authors: A S
authors: AS
authors: Zamay
authors: Voino-Yasenetski Krasnoyarsk State Medical University, Krasnoyarsk, Russia.
authors: M A
authors: MA
authors: Komarova
authors: Kryzhanovsky Krasnoyarsk Regional Clinical Cancer Center, Krasnoyarsk, Russia.
authors: A V
authors: AV
authors: Krat
authors: Voino-Yasenetski Krasnoyarsk State Medical University, Krasnoyarsk, Russia; Kryzhanovsky Krasnoyarsk Regional Clinical Cancer Center, Krasnoyarsk, Russia.
authors: E N
authors: EN
authors: Eremina
authors: Voino-Yasenetski Krasnoyarsk State Medical University, Krasnoyarsk, Russia; Kryzhanovsky Krasnoyarsk Regional Clinical Cancer Center, Krasnoyarsk, Russia.
authors: R A
authors: RA
authors: Zukov
authors: Kirensky Institute of Physics, Krasnoyarsk, Russia.
authors: A E
authors: AE
authors: Sokolov
authors: Kirensky Institute of Physics, Krasnoyarsk, Russia; Voino-Yasenetski Krasnoyarsk State Medical University, Krasnoyarsk, Russia.
authors: T N
authors: TN
authors: Zamay
mesh_terms: D052157:Aptamers, Nucleotide / Q000737:chemistry* / Q000494:pharmacology; D001943:Breast Neoplasms / Q000175:diagnosis* / Q000378:metabolism; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D052156:SELEX Aptamer Technique
chemical_list: D052157:Aptamers, Nucleotide
keywords: DNA-aptamers; SELEX; breast cancer; oligonucleotides