title: Posture-cognitive dual-tasking: A relevant marker of depression-related psychomotor retardation. An illustration of the positive impact of repetitive transcranial magnetic stimulation in patients with major depressive disorder.
abstract: This study examined whether postural control variables, particularly the center-of-pressure (COP) velocity-based parameters, could be a relevant hallmark of depression-related psychomotor retardation (PMR). We first aimed at investigating the interplay between the PMR scores and the COP performance in patients with major depressive disorder (MDD), as compared to age-matched healthy controls; secondly, we focused on the impact of a repetitive transcranial magnetic stimulation (rTMS) treatment on depression, PMR scores and postural performance. 16 MDD patients, and a control group of 16 healthy adults, were asked to maintain quiet standing balance during two trials with or without vision, and while backward counting (dual task). All the position and velocity-based COP variables were computed. Before and after the rTMS session (n eligible MDD = 10), we assessed the depression level with the Montgomery-Asberg Depression Rating Scale (MADRS), the PMR scores with the French Retardation Rating Scale for Depression (ERD), and postural performance. Before the treatment, significant positive partial correlations were found between the pre-ERD scores and the velocity-based COP variables, especially in the dual-task conditions (p < 0.05). In contrast, there was no significant correlation between the post-ERD scores and any postural parameter after the treatment. The MADRS and ERD scores showed a significant decrease between before and after the rTMS intervention. For the first time, the findings clearly validated the view that the assessment of postural performance - easy to envisage in clinical settings-constitutes a reliable and objective marker of PMR in MDD patients.
authors: Laboratory "Movement, Interactions, Performance" (E.A. 4334), University of Nantes, France. Electronic address: thibault.deschamps@univ-nantes.fr.
authors: Thibault
authors: T
authors: Deschamps
authors: CHU de Nantes, Service d'Addictologie et Psychiatrie de liaison, France; EA SPHERE 4275 Methods for Patients-centered outcomes and Health Research, University of Nantes, Nantes, France.
authors: Anne
authors: A
authors: Sauvaget
authors: CHU de Nantes, Service d'Addictologie et Psychiatrie de liaison, France.
authors: Anne
authors: A
authors: Pichot
authors: CHU de Nantes, Service d'Addictologie et Psychiatrie de liaison, France.
authors: Pierre
authors: P
authors: Valrivière
authors: Laboratory "Movement, Interactions, Performance" (E.A. 4334), University of Nantes, France.
authors: Maxime
authors: M
authors: Maroulidès
authors: Laboratory "Movement, Interactions, Performance" (E.A. 4334), University of Nantes, France.
authors: Aurore
authors: A
authors: Bois
authors: CHU de Nantes, Service d'Addictologie et Psychiatrie de liaison, France.
authors: Samuel
authors: S
authors: Bulteau
authors: Laboratory "Movement, Interactions, Performance" (E.A. 4334), University of Nantes, France.
authors: Véronique
authors: V
authors: Thomas-Ollivier
mesh_terms: D000328:Adult; D000368:Aged; D000704:Analysis of Variance; D003071:Cognition / Q000502:physiology*; D003865:Major Depressive Disorder / Q000150:complications* / Q000628:therapy*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D004856:Postural Balance; D011187:Posture / Q000502:physiology*; D011569:Psychiatric Status Rating Scales; D011596:Psychomotor Disorders / Q000209:etiology*; D013223:Statistics as Topic; D050781:Transcranial Magnetic Stimulation / Q000379:methods*
keywords: Depression; Posture; Psychomotor retardation; rTMS