title: Solute solver 'what if' module for modeling urea kinetics.
abstract: The publicly available Solute Solver module allows calculation of a variety of two-pool urea kinetic measures of dialysis adequacy using pre- and postdialysis plasma urea and estimated dialyzer clearance or estimated urea distribution volumes as inputs. However, the existing program does not have a 'what if' module, which would estimate the plasma urea values as well as commonly used measures of hemodialysis adequacy for a patient with a given urea distribution volume and urea nitrogen generation rate dialyzed according to a particular dialysis schedule.
  
  
  
  Conventional variable extracellular volume 2-pool urea kinetic equations were used.
  
  
  
  A javascript-HTML Web form was created that can be used on any personal computer equipped with internet browsing software, to compute commonly used Kt/V-based measures of hemodialysis adequacy for patients with differing amounts of residual kidney function and following a variety of treatment schedules.
  
  
  
  The completed Web form calculator may be particularly useful in computing equivalent continuous clearances for incremental hemodialysis strategies.
authors: University of Illinois at Chicago, Chicago, IL 60612, USA.
authors: John T
authors: JT
authors: Daugirdas
mesh_terms: D001806:Blood Urea Nitrogen; D006801:Humans; D007700:Kinetics; D008954:Models, Biological; D006435:Renal Dialysis / Q000379:methods*; D051437:Renal Insufficiency / Q000378:metabolism* / Q000628:therapy; D014508:Urea / Q000378:metabolism*
chemical_list: D014508:Urea
keywords: dialysis adequacy; dialysis dose; hemodialysis; urea; urea kinetics