title: Upregulated TRIM32 correlates with enhanced cell proliferation and poor prognosis in hepatocellular carcinoma.
abstract: Hepatocellular carcinoma (HCC) is a major type of primary liver cancer and the sixth most prevalent human malignancies worldwide. However, the molecular mechanisms underlying hepatocarcinogenesis remain unclear. For HCC patients, there is not only a lack of effective therapeutic targets but also a lack of predictive or prognostic biomarkers. In this article, we reported that TRIM32 was obviously upregulated in HCC tumor tissues and HCC cell lines. Its expression patterns were positively correlated with histological grade, tumor sizes, and HBsAg of HCC patients. TRIM32 expression was a significant predictor for the overall survival time of HCC patients. Moreover, the overexpression of TRIM32 in cells accelerated the G1-S phase transition, promoted cell proliferation rates, and induced the resistance of HCC patients to oxaliplatin. All these findings suggest that TRIM32 might play important roles in the hepatocarcinogenesis. TRIM32 could be a novel direction to explore the mechanism underlying HCC pathogenesis.
authors: Department of General Surgery, Affiliated Hospital of Nantong University, Medical College of Nantong University, Nantong, 226001, Jiangsu, People's Republic of China.
authors: Xiaopeng
authors: X
authors: Cui
authors: Department of Gastroenterology, Affiliated Hospital of Nantong University, Nantong, 226001, Jiangsu, People's Republic of China.
authors: Zhipeng
authors: Z
authors: Lin
authors: Class 5 Grade 13, Clinical Medicine, Medical College, Nantong University, Nantong, 226001, Jiangsu, People's Republic of China.
authors: Yuyan
authors: Y
authors: Chen
authors: Department of Stomatology, The First Affiliated Hospital of Dalian Medical University, Dalian, 116000, Liaoning, People's Republic of China.
authors: Xiaofei
authors: X
authors: Mao
authors: Department of Gastroenterology, Affiliated Hospital of Nantong University, Nantong, 226001, Jiangsu, People's Republic of China.
authors: Wenkai
authors: W
authors: Ni
authors: Department of Gastroenterology, Affiliated Hospital of Nantong University, Nantong, 226001, Jiangsu, People's Republic of China.
authors: Jinxia
authors: J
authors: Liu
authors: Key Laboratory of Neuroregeneration, Nantong University, Nantong, 226001, Jiangsu, People's Republic of China.
authors: Huiling
authors: H
authors: Zhou
authors: Department of Gastroenterology, Affiliated Hospital of Nantong University, Nantong, 226001, Jiangsu, People's Republic of China.
authors: Xiaohang
authors: X
authors: Shan
authors: Department of Gastroenterology, Affiliated Hospital of Nantong University, Nantong, 226001, Jiangsu, People's Republic of China.
authors: Lingling
authors: L
authors: Chen
authors: Department of Gastroenterology, Affiliated Hospital of Nantong University, Nantong, 226001, Jiangsu, People's Republic of China.
authors: Jiale
authors: J
authors: Lv
authors: Department of Gastroenterology, Affiliated Hospital of Nantong University, Nantong, 226001, Jiangsu, People's Republic of China.
authors: Zhongyi
authors: Z
authors: Shen
authors: The Second Peoples' Hospital of Nantong, Nantong, 226001, Jiangsu, People's Republic of China.
authors: Chengwei
authors: C
authors: Duan
authors: Basic Medical Research Centre, Medical College, Nantong University, Nantong, 226001, Jiangsu, People's Republic of China. hubynt@sohu.com.
authors: Baoying
authors: B
authors: Hu
authors: Department of Gastroenterology, Affiliated Hospital of Nantong University, Nantong, 226001, Jiangsu, People's Republic of China. nirznt@sina.com.
authors: Runzhou
authors: R
authors: Ni
mesh_terms: D000328:Adult; D006528:Carcinoma, Hepatocellular / Q000378:metabolism / Q000401:mortality; D049109:Cell Proliferation; D018572:Disease-Free Survival; D019008:Drug Resistance, Neoplasm / Q000187:drug effects; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008113:Liver Neoplasms / Q000378:metabolism / Q000401:mortality; D008297:Male; D008875:Middle Aged; D009944:Organoplatinum Compounds / Q000008:administration & dosage; D000077150:Oxaliplatin; D015996:Survival Rate; D014157:Transcription Factors / Q000096:biosynthesis*; D000070584:Tripartite Motif Proteins / Q000096:biosynthesis*; D044767:Ubiquitin-Protein Ligases / Q000096:biosynthesis*
chemical_list: D009944:Organoplatinum Compounds; D014157:Transcription Factors; D000070584:Tripartite Motif Proteins; D000077150:Oxaliplatin; C094027:TRIM32 protein, human; D044767:Ubiquitin-Protein Ligases
keywords: Cell proliferation; Hepatocellular carcinoma; Prognosis; TRIM32