title: Osteonecrosis of the Jaw in the Absence of Antiresorptive or Antiangiogenic Exposure: A Series of 6 Cases.
abstract: OBJECTIVE
  Medication-related osteonecrosis of the jaws (MRONJ) is a well-described complication of antiresorptive and antiangiogenic medications. Although osteonecrosis can be associated with other inciting events and medications, such as trauma, infection, steroids, chemotherapy, and coagulation disorders, these are rarely reported in the literature.
  
  
  METHODS
  This is a six case series of MRONJ associated with medications other than antiresorptive or antiangiogenic drugs.
  
  
  RESULTS
  Patient demographics, inciting event, location, stage, imaging findings, and outcome are reported.
  
  
  CONCLUSIONS
  With the continued development and clinical use of new biologic medications for diseases such as cancer and rheumatoid arthritis, it is important to continue to evaluate their effects on the oral cavity. The degree of risk for osteonecrosis in patients taking these new classes of drugs is uncertain but warrants awareness and monitoring.
authors: Professor, Section of Oral and Maxillofacial Surgery, Division of Diagnostic and Surgical Sciences, UCLA School of Dentistry, Los Angeles, CA. Electronic address: taghaloo@dentistry.ucla.edu.
authors: Tara L
authors: TL
authors: Aghaloo
authors: Professor, Section of Oral and Maxillofacial Surgery, Division of Diagnostic and Surgical Sciences, UCLA School of Dentistry, Los Angeles, CA.
authors: Sotirios
authors: S
authors: Tetradis
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D054893:Cone-Beam Computed Tomography; D005260:Female; D006801:Humans; D007568:Jaw / Q000473:pathology; D007571:Jaw Diseases / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000209:etiology* / Q000473:pathology; D008875:Middle Aged; D010020:Osteonecrosis / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000209:etiology* / Q000473:pathology; D011859:Radiography