title: Recent Advances in Computational Models for the Study of Protein-Peptide Interactions.
abstract: We review computational models and software tools in current use for the study of protein-peptide interactions. Peptides and peptide derivatives are growing in interest as therapeutic agents to target protein-protein interactions. Protein-protein interactions are pervasive in biological systems and are responsible for the regulation of critical functions within the cell. Mutations or dysregulation of expression can alter the network of interactions among proteins and cause diseases such as cancer. Protein-protein binding interfaces, which are often large, shallow, and relatively feature-less, are difficult to target with small-molecule inhibitors. Peptide derivatives based on the binding motifs present in the target protein complex are increasingly drawing interest as superior alternatives to conventional small-molecule inhibitors. However, the design of peptide-based inhibitors also presents novel challenges. Peptides are more complex and more flexible than standard medicinal compounds. They also tend to form more extended and more complex interactions with their protein targets. Computational modeling is increasingly being employed to supplement synthetic and biochemical work to offer guidance and energetic and structural insights. In this review, we discuss recent in silico structure-based and physics-based approaches currently employed to model protein-peptide interactions with a few examples of their applications.
authors: Brooklyn College, Brooklyn, NY, United States; The Graduate Center of the City University of New York, New York, NY, United States.
authors: D
authors: D
authors: Kilburg
authors: Brooklyn College, Brooklyn, NY, United States; The Graduate Center of the City University of New York, New York, NY, United States. Electronic address: egallicchio@brooklyn.cuny.edu.
authors: E
authors: E
authors: Gallicchio
mesh_terms: D003198:Computer Simulation; D056004:Molecular Dynamics Simulation; D010455:Peptides / Q000737:chemistry*; D011506:Proteins / Q000737:chemistry*
chemical_list: D010455:Peptides; D011506:Proteins
keywords: BEDAM; Double decoupling; Free energy; Free energy perturbation; MM-PBSA; Molecular dynamics; Peptide binding; Protein–peptide docking