title: Cerebellar EBV-associated diffuse large B cell lymphoma following angioimmunoblastic T cell lymphoma.
abstract: Epstein-Barr virus (EBV)-associated B cell lymphoproliferative disorders may be seen in patients with angioimmunoblastic T cell lymphoma (AITL). Although both nodal and extranodal sites of involvement have been described, central nervous system involvement by B cell lymphoma following AITL has not previously been documented. We report a first example of such unusual presentation, in which an 80-year-old man developed diffuse large B cell lymphoma (DLBCL) in the cerebellum 4 months after the initial diagnosis of AITL. EBV-encoded RNAs were detected in the DLBCL, suggesting that EBV played a pivotal role in the pathogenesis of high-grade histologic progression of AITL. The patient survived less than 9 months after his initial diagnosis of AITL. We believe that this case expands the spectrum of extranodal manifestation of EBV-positive B cell lymphoma associated with AITL and illustrates the importance of recognition of this association when encountering unusual central nervous system lesions in patients with known AITL.
authors: Department of Pathology, Loyola University Medical Center, Rm 2222, Building 110, 2160 S 1st Ave, Maywood, IL 60153, USA.
authors: Yi
authors: Y
authors: Zhou
authors: Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA.
authors: Marc K
authors: MK
authors: Rosenblum
authors: Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA.
authors: Ahmet
authors: A
authors: Dogan
authors: Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA.
authors: Achim A
authors: AA
authors: Jungbluth
authors: Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA.
authors: April
authors: A
authors: Chiu
keywords: Angioimmunoblastic Tcell lymphoma; Central nervous system; Diffuse large B cell lymphoma