title: External Validation of the Lupus Impact Tracker in a Southeastern US Longitudinal Cohort With Systemic Lupus Erythematosus.
abstract: To examine the external validity of the Lupus Impact Tracker (LIT), a systemic lupus erythematosus (SLE)-specific, health-related quality of life (HRQoL) tool in a population-based cohort of patients with SLE in Atlanta, Georgia. We modeled the association of LIT scores with patient-reported measures of SLE activity (Systemic Lupus Activity Questionnaire [SLAQ]) and organ damage (self-administered Brief Index of Lupus Damage [SA-BILD]). We investigated the association of LIT scores with general HRQoL using the Short Form 12 (SF-12).
  
  
  
  Correlation, multivariable regression, and longitudinal analyses using general linear modeling with fixed effects were performed to investigate the association between the LIT and patient-reported disease activity (SLAQ); patient-reported disease damage (SA-BILD); mental health (mental component summary [MCS] of the SF-12); and physical health (physical component summary [PCS] of the SF-12). Demographic trends related to the LIT were also assessed using cross-sectional analysis.
  
  
  
  The LIT was significantly associated with disease activity (SLAQ), organ damage (SA-BILD), MCS scores, and PCS scores in both adjusted and unadjusted regression analysis (P < 0.0001). Longitudinal analysis demonstrated a significant association between the LIT and disease activity (SLAQ), MCS scores, and PCS scores (P < 0.0001), but not organ damage (SA-BILD).
  
  
  
  The LIT is a simple, patient-centered tool that can be used to assess HRQoL in patients with SLE. This study provides external validity of the LIT in a population-based cohort with a large number of African American patients with a relatively high disease burden.
authors: Emory University, Atlanta, Georgia.
authors: Jennifer E
authors: JE
authors: Brandt
authors: Emory University, Atlanta, Georgia.
authors: Cristina
authors: 0000-0002-6832-7291
authors: C
authors: Drenkard
authors: Johns Hopkins University, Baltimore, Maryland.
authors: Hong
authors: H
authors: Kan
authors: Emory University, Atlanta, Georgia.
authors: Gaobin
authors: G
authors: Bao
authors: Emory University, Atlanta, Georgia.
authors: Charmayne
authors: C
authors: Dunlop-Thomas
authors: GlaxoSmithKline, Philadelphia, Pennsylvania.
authors: Bonnie
authors: B
authors: Pobiner
authors: GlaxoSmithKline, Philadelphia, Pennsylvania.
authors: David J
authors: DJ
authors: Chang
authors: Rush University Medical Center, Chicago, Illinois.
authors: Meenakshi
authors: M
authors: Jolly
authors: Emory University, Atlanta, Georgia.
authors: S Sam
authors: SS
authors: Lim
mesh_terms: D000293:Adolescent; D000328:Adult; D015331:Cohort Studies; D003430:Cross-Sectional Studies; D005260:Female; D005845:Georgia / Q000453:epidemiology; D006306:Health Surveys / Q000592:standards*; D006801:Humans; D008137:Longitudinal Studies; D008180:Lupus Erythematosus, Systemic / Q000175:diagnosis* / Q000453:epidemiology* / Q000523:psychology; D008297:Male; D008875:Middle Aged; D011788:Quality of Life / Q000523:psychology; D012042:Registries / Q000592:standards; D015144:Southeastern United States / Q000453:epidemiology; D055815:Young Adult