title: IL-8 interacts with metadherin promoting proliferation and migration in gastric cancer.
abstract: It has been reported that IL-8 was involved in the promotion of invasion of Gastric Cancer (GC), however the underlying mechanism by which IL-8 was observed to be able to promote invasion remains unknown. Here, in our study, IL-8 was shown to be significantly up-regulated in GC compared with paired normal control tissues whose expression was markedly associated with inferior overall prognosis; and IL-8 was displayed to be capable of directly interacting with metadherin (MTDH), which in turn can up-regulate IL-8 expression. Blockage of IL-8/MTDH using specific mono-antibody can abolish the invasion IL-8 mediated. Taken together, our results may provide a novel explanation of working mechanism of IL-8 in the invasion of GC.
authors: The Department of Gastrointestinal and Anus Surgery, The Affiliated Longyan First Hospital of Fujian Medical University, Longyan, 364000, Fujian Province, PR China.
authors: Wenfeng
authors: W
authors: Li
authors: The Department of Gastrointestinal and Anus Surgery, The Affiliated Longyan First Hospital of Fujian Medical University, Longyan, 364000, Fujian Province, PR China.
authors: Shuangming
authors: S
authors: Lin
authors: The Department of General Surgery, The First Affiliated Hospital of Nanchang University, Nanchang, 330006, Jiangxi Province, PR China.
authors: Wenhuan
authors: W
authors: Li
authors: The Department of General Surgery, The First Affiliated Hospital of Nanchang University, Nanchang, 330006, Jiangxi Province, PR China.
authors: Weijun
authors: W
authors: Wang
authors: The Department of General Surgery, The First Affiliated Hospital of Nanchang University, Nanchang, 330006, Jiangxi Province, PR China. Electronic address: ncdxyfy_xuemingli@163.com.
authors: Xueming
authors: X
authors: Li
authors: The Department of Gastrointestinal and Anus Surgery, The Affiliated Longyan First Hospital of Fujian Medical University, Longyan, 364000, Fujian Province, PR China. Electronic address: fmualfh_dbxu@163.com.
authors: Dongbo
authors: D
authors: Xu
mesh_terms: D016022:Case-Control Studies; D015815:Cell Adhesion Molecules / Q000378:metabolism*; D045744:Cell Line, Tumor; D002465:Cell Movement; D049109:Cell Proliferation; D005260:Female; D006801:Humans; D016209:Interleukin-8 / Q000378:metabolism*; D008297:Male; D008565:Membrane Proteins; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009500:Neutralization Tests; D011485:Protein Binding; D016601:RNA-Binding Proteins; D013274:Stomach Neoplasms / Q000378:metabolism* / Q000473:pathology*; D015854:Up-Regulation
chemical_list: D015815:Cell Adhesion Molecules; D016209:Interleukin-8; C483039:MTDH protein, human; D008565:Membrane Proteins; D016601:RNA-Binding Proteins
keywords: Gastric cancer; IL-8; Invasion; MTDH; Prognosis