title: Imaging Pulmonary Inflammation.
abstract: Lung inflammatory diseases contribute significantly to the socioeconomic burden of disease. Yet very few new, effective therapies for respiratory disease have been approved for use. A major contributing factor is the lack of biomarkers that can accurately quantify the lung inflammatory burden and can be used to understand the contribution of lung inflammation to loss in lung function. Molecular imaging approaches can detect and quantify the recruitment and activation of specific immune cells in lung inflammation. We review the clinical techniques used to image lung inflammation, provide an overview of clinical and emerging PET techniques for quantifying lung inflammation, and discuss potential clinical applications.
authors: Washington University School of Medicine, St. Louis, Missouri.
authors: Philip M
authors: PM
authors: Scherer
authors: Washington University School of Medicine, St. Louis, Missouri chend@wustl.edu.
authors: Delphine L
authors: DL
authors: Chen
mesh_terms: D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D008168:Lung / Q000000981:diagnostic imaging* / Q000276:immunology* / Q000473:pathology; D011014:Pneumonia / Q000000981:diagnostic imaging* / Q000276:immunology* / Q000473:pathology; D049268:Positron-Emission Tomography / Q000379:methods*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity
keywords: lung inflammation; molecular imaging; positron emission tomography; pulmonary