title: Mayer waves reduce the accuracy of estimated hemodynamic response functions in functional near-infrared spectroscopy.
abstract: Analysis of cerebral hemodynamics reveals a wide spectrum of oscillations ranging from 0.0095 to 2 Hz. While most of these oscillations can be filtered out during analysis of functional near-infrared spectroscopy (fNIRS) signals when estimating stimulus evoked hemodynamic responses, oscillations around 0.1 Hz are an exception. This is due to the fact that they share a common spectral range with typical stimulus evoked hemodynamic responses from the brain. Here we investigate the effect of hemodynamic oscillations around 0.1 Hz on the estimation of hemodynamic response functions from fNIRS data. Our results show that for an expected response of ~1 µM in oxygenated hemoglobin concentration (HbO), Mayer wave oscillations with an amplitude > ~1 µM at 0.1 Hz reduce the accuracy of the estimated response as quantified by a 3 fold increase in the mean squared error and decrease in correlation (R(2) below 0.78) when compared to the true HRF. These results indicate that the amplitude of oscillations at 0.1 Hz can serve as an objective metric of the expected HRF estimation accuracy. In addition, we investigated the effect of short separation regression on the recovered HRF, and found that this improves the recovered HRF when large amplitude 0.1 Hz oscillations are present in fNIRS data. We suspect that the development of other filtering strategies may provide even further improvement.
authors: MGH/HST Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital (MGH), Harvard Medical School, Charlestown, MA, USA.
authors: Meryem A
authors: MA
authors: Yücel
authors: MGH/HST Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital (MGH), Harvard Medical School, Charlestown, MA, USA.
authors: Juliette
authors: J
authors: Selb
authors: Center for Pain and the Brain, Departments of Anaesthesia and Radiology, Boston Children's Hospital, Boston, MA, USA.
authors: Christopher M
authors: CM
authors: Aasted
authors: MGH/HST Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital (MGH), Harvard Medical School, Charlestown, MA, USA.
authors: Pei-Yi
authors: PY
authors: Lin
authors: Center for Pain and the Brain, Departments of Anaesthesia and Radiology, Boston Children's Hospital, Boston, MA, USA.
authors: David
authors: D
authors: Borsook
authors: Center for Pain and the Brain, Departments of Anaesthesia and Radiology, Boston Children's Hospital, Boston, MA, USA.
authors: Lino
authors: L
authors: Becerra
authors: MGH/HST Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital (MGH), Harvard Medical School, Charlestown, MA, USA.
authors: David A
authors: DA
authors: Boas
keywords: (170.2655) Functional monitoring and imaging; (200.4560) Optical data processing