title: Recent advances in porous nanoparticles for drug delivery in antitumoral applications: inorganic nanoparticles and nanoscale metal-organic frameworks.
abstract: Nanotechnology has provided new tools for addressing unmet clinical situations, especially in the oncology field. The development of smart nanocarriers able to deliver chemotherapeutic agents specifically to the diseased cells and to release them in a controlled way has offered a paramount advantage over conventional therapy. Areas covered: Among the different types of nanoparticle that can be employed for this purpose, inorganic porous materials have received significant attention in the last decade due to their unique properties such as high loading capacity, chemical and physical robustness, low toxicity and easy and cheap production in the laboratory. This review discuss the recent advances performed in the application of porous inorganic and metal-organic materials for antitumoral therapy, paying special attention to the application of mesoporous silica, porous silicon and metal-organic nanoparticles. Expert opinion: The use of porous inorganic nanoparticles as drug carriers for cancer therapy has the potential to improve the life expectancy of the patients affected by this disease. However, much work is needed to overcome their drawbacks, which are aggravated by their hard nature, exploiting the advantages offered by highly the ordered pore network of these materials.
authors: a Center on Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN) , GIBI_UCM group , Madrid , Spain.|b Departamento de Química Inorgánica y Bioinorgánica, Facultad de Farmacia , Universidad Complutense de Madrid, Instituto de Investigación Sanitaria Hospital 12 de Octubre i+12 , Madrid , Spain.
authors: Alejandro
authors: A
authors: Baeza
authors: c Catalan Institute of Nanoscience and Nanotechnology (ICN2) , CSIC and The Barcelona Institute of Science and Technology , Barcelona , Spain.
authors: Daniel
authors: D
authors: Ruiz-Molina
authors: a Center on Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN) , GIBI_UCM group , Madrid , Spain.|b Departamento de Química Inorgánica y Bioinorgánica, Facultad de Farmacia , Universidad Complutense de Madrid, Instituto de Investigación Sanitaria Hospital 12 de Octubre i+12 , Madrid , Spain.
authors: María
authors: M
authors: Vallet-Regí
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage*; D004337:Drug Carriers / Q000737:chemistry; D016503:Drug Delivery Systems; D006801:Humans; D053768:Metal Nanoparticles; D008670:Metals / Q000737:chemistry; D053758:Nanoparticles; D036103:Nanotechnology; D016062:Porosity; D012825:Silicon / Q000737:chemistry; D012822:Silicon Dioxide / Q000737:chemistry
chemical_list: D000970:Antineoplastic Agents; D004337:Drug Carriers; D008670:Metals; D012822:Silicon Dioxide; D012825:Silicon
keywords: Cancer nanomedicine; mesoporous silica nanoparticles; metal-organic frameworks; porous inorganic nanomaterials; porous silicon nanoparticles