title: Morbidity and mortality associated with rewarming hypothermic very low birth weight infants.
abstract: OBJECTIVE
  In very low birthweight (VLBW) infants, hypothermia is associated with poor outcomes. The goal of this study is to assess the relationship between the rate of rewarming these babies and their outcomes.
  
  
  METHODS
  This is a retrospective cohort study of 98 inborn VLBW infants who were hypothermic (<36°C rectally) upon admission to the NICU. A logistic regression model was used to examine the relationship between the rates of rewarming and time to achieve euthermia and the following outcomes: death, intraventricular hemorrhage, severe intraventricular hemorrhage, bronchopulmonary dysplasia, necrotizing enterocolitis and retinopathy of prematurity.
  
  
  RESULTS
  Prolonged rewarming time was associate with increased odds of mortality (OR 1.273 95% CI 1.032-1.571). No associations between rewarming rates and any of the outcomes were seen. Once birthweight was included in a multiple logistic regression model, the association between mortality and rewarming time was no longer significant. Outcomes that were not associated with either rate or time of rewarming (even in a univariate model) were: bronchopulmonary dysplasia, intraventricular hemorrhage, severe intraventricular hemorrhage, necrotizing enterocolitis and retinopathy of prematurity.
  
  
  CONCLUSIONS
  In moderately hypothermic VLBW infants, after accounting for birthweight, no association between rewarming and outcome is seen.
authors: Department of Pediatrics, Maria Fareri Children's Hospital at Westchester Medical Center, New York Medical College, Valhalla, New York, USA.|Department of Pediatrics, Rutgers University - New Jersey Medical School, Newark, NJ, USA.
authors: A
authors: A
authors: Feldman
authors: Department of Pediatrics, Maria Fareri Children's Hospital at Westchester Medical Center, New York Medical College, Valhalla, New York, USA.
authors: B
authors: B
authors: De Benedictis
authors: Department of Pediatrics, Maria Fareri Children's Hospital at Westchester Medical Center, New York Medical College, Valhalla, New York, USA.
authors: Gad
authors: G
authors: Alpan
authors: Department of Pediatrics, Maria Fareri Children's Hospital at Westchester Medical Center, New York Medical College, Valhalla, New York, USA.
authors: E F
authors: EF
authors: La Gamma
authors: Department of Pediatrics, Maria Fareri Children's Hospital at Westchester Medical Center, New York Medical College, Valhalla, New York, USA.
authors: J
authors: J
authors: Kase
mesh_terms: D001724:Birth Weight; D001997:Bronchopulmonary Dysplasia; D002543:Cerebral Hemorrhage; D020345:Enterocolitis, Necrotizing; D005260:Female; D006801:Humans; D007035:Hypothermia / Q000151:congenital* / Q000401:mortality / Q000503:physiopathology / Q000628:therapy*; D007231:Infant, Newborn; D007234:Infant, Premature; D019102:Infant, Very Low Birth Weight; D007363:Intensive Care Units, Neonatal; D008297:Male; D009518:New York / Q000453:epidemiology; D012189:Retrospective Studies; D017694:Rewarming / Q000009:adverse effects* / Q000379:methods / Q000401:mortality*; D013997:Time Factors
keywords: Very low birth weight; hypothermia; rewarming rate; rewarming time