title: Spontaneous Cannabinoid Receptor 2 (CB2) Expression in the Cochlea of Adult Albino Rat and Its Up-Regulation after Cisplatin Treatment.
abstract: We provide evidence for the presence of cannabinoid CB2 receptors in some cellular types of the cochlea of the adult albino rat. Cannabinoids and their receptors are increasingly being studied because of their high potential for clinical use. As a hyperspecialized portion of the peripheral nervous system, study of the expression and function of cannabinoid receptors in the hearing organ is of high interest. Stria vascularis and inner hair cells express CB2 receptor, as well as neurites and cell bodies of the spiral ganglion. Cellular types such as supporting cells and outer hair cells, in which the expression of other types of functional receptors has been reported, do not significantly express CB2 receptors in this study. An up-regulation of CB2 gene expression was detected after an ototoxic event such as cisplatin treatment, probably due to pro-inflammatory events triggered by the drug. That fact suggests promising potential of CB2 receptor as a therapeutic target for new treatments to palliate cisplatin-induced hearing loss and other ototoxic events which triggers inflammatory pathways.
authors: Ear Research Group, Universitary Hospital Puerta de Hierro Majadahonda- Health Research Institute Puerta de Hierro, Madrid, Spain.
authors: Sergio
authors: http://orcid.org/0000-0002-9506-8483
authors: S
authors: Martín-Saldaña
authors: Ear Research Group, Universitary Hospital Puerta de Hierro Majadahonda- Health Research Institute Puerta de Hierro, Madrid, Spain.
authors: Almudena
authors: A
authors: Trinidad
authors: Sequencing and Molecular Biology Unit, Universitary Hospital Puerta de Hierro Majadahonda, Health Research Institute Puerta de Hierro, Madrid, Spain.
authors: Elvira
authors: E
authors: Ramil
authors: Neuroimmunology Unit, Universitary Hospital Puerta de Hierro Majadahonda- Health Research Institute Puerta de Hierro, Madrid, Spain.
authors: Antonio J
authors: AJ
authors: Sánchez-López
authors: Confocal Microscopy Unit, Universitary Hospital Puerta de Hierro Majadahonda, Health Research Institute Puerta de Hierro, Madrid, Spain.
authors: Maria José
authors: MJ
authors: Coronado
authors: Department of Medical Oncology, Universitary Hospital Puerta de Hierro Majadahonda- Health Research Institute Puerta de Hierro, Madrid, Spain.
authors: Esther
authors: E
authors: Martínez-Martínez
authors: Department of Medical Oncology, Universitary Hospital Puerta de Hierro Majadahonda- Health Research Institute Puerta de Hierro, Madrid, Spain.
authors: José Miguel
authors: JM
authors: García
authors: Ear Research Group, Universitary Hospital Puerta de Hierro Majadahonda- Health Research Institute Puerta de Hierro, Madrid, Spain.
authors: José Ramón
authors: JR
authors: García-Berrocal
authors: Ear Research Group, Universitary Hospital Puerta de Hierro Majadahonda- Health Research Institute Puerta de Hierro, Madrid, Spain.
authors: Rafael
authors: R
authors: Ramírez-Camacho
mesh_terms: D000818:Animals; D002945:Cisplatin / Q000494:pharmacology*; D003051:Cochlea / Q000187:drug effects* / Q000378:metabolism*; D007758:Ear, Inner / Q000187:drug effects / Q000378:metabolism*; D005260:Female; D005455:Fluorescent Antibody Technique; D007150:Immunohistochemistry; D051381:Rats; D017208:Rats, Wistar; D043885:Receptor, Cannabinoid, CB2 / Q000235:genetics / Q000378:metabolism*
chemical_list: D043885:Receptor, Cannabinoid, CB2; D002945:Cisplatin