title: Cilostazol Effect on Amikacin-Induced Ototoxicity: An Experimental Study.
abstract: To find out the possible protective effect of cilostazol against amikacin-induced ototoxicity.
  
  
  
  This study was carried out on 24 adult male rats classified into 4 equal groups of 6 animals each. (1) The control group was administered saline (1 ml/day, p.o.) for 14 days. (2) The amikacin group was administered amikacin (200 mg/kg, i.m.) once daily for 14 days. (3) The cilostazol-amikacin (14 days) group was administered cilostazol (30 mg/kg, p.o.) once daily and amikacin (200 mg/kg, i.m.) once daily for 14 days. (4) The cilostazol (28 days)-amikacin (14 days) group was administered cilostazol (30 mg/kg, p.o.) once daily for 28 days and amikacin (200 mg/kg, i.m.) once daily for 14 days. Changes in the transient evoked otoacoustic emissions (TEOAEs) in the 4 groups were interpreted statistically.
  
  
  
  No reported significant differences in TEOAE levels were detected between the groups at the start of the study. In all frequency bands, TEOAEs disappeared after amikacin treatment in the amikacin-alone group and remained absent in the amikacin-cilostazol (14 days) group, while TEOAEs reappeared in the amikacin-cilostazol (28 days) group.
  
  
  
  Cilostazol treatment for 28 days had a protective effect against amikacin-induced ototoxicity in rats.
authors: Otorhinolaryngology, Head and Neck Surgery Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt.
authors: Mohammad Waheed
authors: MW
authors: El-Anwar
authors: Said
authors: S
authors: Abdelmonem
authors: Ebtessam
authors: E
authors: Nada
authors: Dalia
authors: D
authors: Galhoom
authors: Ahmed A
authors: AA
authors: Abdelsameea
mesh_terms: D000583:Amikacin / Q000633:toxicity*; D000818:Animals; D000900:Anti-Bacterial Agents / Q000633:toxicity*; D000077407:Cilostazol; D034381:Hearing Loss / Q000139:chemically induced* / Q000517:prevention & control; D008297:Male; D018696:Neuroprotective Agents / Q000494:pharmacology*; D017084:Otoacoustic Emissions, Spontaneous / Q000187:drug effects*; D051381:Rats; D013777:Tetrazoles / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D018696:Neuroprotective Agents; D013777:Tetrazoles; D000583:Amikacin; D000077407:Cilostazol