title: Up-Conversion Y2O3:Yb(3+),Er(3+) Hollow Spherical Drug Carrier with Improved Degradability for Cancer Treatment.
abstract: The rare earth hollow spheres with up-conversion luminescence properties have shown potential applications in drug delivery and bioimaging fields. However, there have been few reports for the degradation properties of rare earth oxide drug carriers. Herein, uniform and well-dispersed Y2O3:Yb(3+),Er(3+) hollow spheres (YOHSs) have been fabricated by a general Pechini sol-gel process with melamine formaldehyde colloidal spheres as template. The novel YOHSs with up-conversion luminescence has good drug loading amount and drug-release efficiency; moreover, it exhibits pH-responsive release patterns. In particular, the YOHSs sample exhibits low cytotoxicity and excellent degradable properties in acid buffer. After the sample was loaded with anticancer drug doxorubicin (DOX), the antitumor result in vitro indicates that YOHS-DOX might be effective in cancer treatment. The animal imaging test also reveals that the YOHSs drug carrier can be used as an outstanding luminescent probe for bioimaging in vivo application prospects. The results suggest that the degradable drug carrier with up-conversion luminescence may enhance the delivery efficiency of drugs and improve the cancer therapy in clinical applications.
authors: Key Laboratory of Chemical Biology of Hebei Province, Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of the Ministry of Education, College of Chemistry & Environmental Science, Hebei University , Baoding 071002, P. R. China.|Affiliated Hospital of Hebei University , Baoding 071000, P.R. China.
authors: Kun
authors: K
authors: Ge
authors: Key Laboratory of Chemical Biology of Hebei Province, Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of the Ministry of Education, College of Chemistry & Environmental Science, Hebei University , Baoding 071002, P. R. China.
authors: Cuimiao
authors: C
authors: Zhang
authors: Key Laboratory of Chemical Biology of Hebei Province, Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of the Ministry of Education, College of Chemistry & Environmental Science, Hebei University , Baoding 071002, P. R. China.
authors: Wentong
authors: W
authors: Sun
authors: Key Laboratory of Chemical Biology of Hebei Province, Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of the Ministry of Education, College of Chemistry & Environmental Science, Hebei University , Baoding 071002, P. R. China.
authors: Huifang
authors: H
authors: Liu
authors: Key Laboratory of Chemical Biology of Hebei Province, Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of the Ministry of Education, College of Chemistry & Environmental Science, Hebei University , Baoding 071002, P. R. China.
authors: Yi
authors: Y
authors: Jin
authors: Key Laboratory of Chemical Biology of Hebei Province, Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of the Ministry of Education, College of Chemistry & Environmental Science, Hebei University , Baoding 071002, P. R. China.
authors: Zhenhua
authors: Z
authors: Li
authors: CAS Key Lab of Nanomaterials Bioeffects and Nanosafety, National Center for Nanoscience and Technology of China , Beijing 100190, P. R. China.
authors: Xing-Jie
authors: XJ
authors: Liang
authors: Key Laboratory of Chemical Biology of Hebei Province, Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of the Ministry of Education, College of Chemistry & Environmental Science, Hebei University , Baoding 071002, P. R. China.
authors: Guang
authors: G
authors: Jia
authors: Key Laboratory of Chemical Biology of Hebei Province, Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of the Ministry of Education, College of Chemistry & Environmental Science, Hebei University , Baoding 071002, P. R. China.
authors: Jinchao
authors: J
authors: Zhang
mesh_terms: D000818:Animals; D004317:Doxorubicin; D004337:Drug Carriers / Q000737:chemistry*; D016503:Drug Delivery Systems; D065546:Drug Liberation; D004871:Erbium; D049449:Luminescence; D009369:Neoplasms; D015019:Yttrium
chemical_list: D004337:Drug Carriers; D015019:Yttrium; D004871:Erbium; D004317:Doxorubicin; C091417:yttria
keywords: Y2O3:Yb3+,Er3+ hollow spheres; cancer therapy; degradability; drug carrier; up-conversion luminescence