title: Increased syndecan-4 expression in sera and skin of patients with atopic dermatitis.
abstract: Syndecan-4 (SDC-4) is a cell surface proteoglycan, which participates in signaling during cell adhesion, migration, proliferation, endocytosis, and mechanotransduction, and is expressed on various cells, including endothelial cells, epithelial cells, T cells, and eosinophils. Emerging evidences have suggested that SDC-4 might contribute to Th2-driven allergic immune responses. Here, we examined the role of SDC-4 in patients with atopic dermatitis (AD). Serum SDC-4 levels in AD patients were significantly higher than in healthy individuals, and they increased according to the disease severity. Importantly, they positively correlated with Eczema Area and Severity Index and itch visual analogue scale scores. Furthermore, serum SDC-4 levels decreased after treatment. We also analyzed SDC-4 expression in AD lesional skin. SDC-4 mRNA levels in AD skin were significantly higher than those of normal skin. Immunohistochemical staining revealed that SDC-4 was highly expressed in the epidermis and endothelial cells in AD lesional skin. Taken together, our study has demonstrated that SDC-4 expression was increased in sera and skin of AD patients, suggesting that SDC-4 may contribute to the development of AD.
authors: Department of Dermatology, University of Tokyo Graduate School of Medicine, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.
authors: Momoko
authors: M
authors: Nakao
authors: Department of Dermatology, University of Tokyo Graduate School of Medicine, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan. sugayam-der@h.u-tokyo.ac.jp.
authors: Makoto
authors: M
authors: Sugaya
authors: Department of Dermatology, University of Tokyo Graduate School of Medicine, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.
authors: Naomi
authors: N
authors: Takahashi
authors: Department of Dermatology, University of Tokyo Graduate School of Medicine, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.
authors: Sayaka
authors: S
authors: Otobe
authors: Department of Dermatology, University of Tokyo Graduate School of Medicine, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.
authors: Rina
authors: R
authors: Nakajima
authors: Department of Dermatology, University of Tokyo Graduate School of Medicine, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.
authors: Tomonori
authors: T
authors: Oka
authors: Department of Dermatology, University of Tokyo Graduate School of Medicine, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.
authors: Miyoko
authors: M
authors: Kabasawa
authors: Department of Dermatology, University of Tokyo Graduate School of Medicine, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.
authors: Hiraku
authors: H
authors: Suga
authors: Department of Dermatology, University of Tokyo Graduate School of Medicine, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.
authors: Sohshi
authors: S
authors: Morimura
authors: Department of Dermatology, University of Tokyo Graduate School of Medicine, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.
authors: Tomomitsu
authors: T
authors: Miyagaki
authors: Department of Dermatology, University of Tokyo Graduate School of Medicine, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.
authors: Hideki
authors: H
authors: Fujita
authors: Department of Dermatology, University of Tokyo Graduate School of Medicine, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.
authors: Yoshihide
authors: Y
authors: Asano
authors: Department of Dermatology, University of Tokyo Graduate School of Medicine, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.
authors: Shinichi
authors: S
authors: Sato
mesh_terms: D000328:Adult; D003876:Dermatitis, Atopic / Q000097:blood / Q000188:drug therapy / Q000378:metabolism*; D042783:Endothelial Cells / Q000378:metabolism; D000078404:Epidermal Cells; D004817:Epidermis / Q000378:metabolism* / Q000473:pathology; D005260:Female; D064368:Healthy Volunteers; D006801:Humans; D008297:Male; D008875:Middle Aged; D011537:Pruritus / Q000378:metabolism*; D012333:RNA, Messenger / Q000378:metabolism; D012720:Severity of Illness Index; D053671:Syndecan-4 / Q000097:blood / Q000378:metabolism*; D055815:Young Adult
chemical_list: D012333:RNA, Messenger; C508304:SDC4 protein, human; D053671:Syndecan-4
keywords: Allergy; Atopic dermatitis; Blood endothelial cells; Syndecan-4