title: Hyperemesis Gravidarum in Undiagnosed Gitelman's Syndrome.
abstract: Introduction. Gitelman's syndrome (GS) is an autosomal recessive inherited defect in the thiazide-sensitive sodium-chloride cotransporter (NCCT) in the renal distal convoluted tubule. Physiologic changes of pregnancy promote renal potassium wasting, but serum potassium levels are kept in the physiologic range by increased levels of progesterone, which resist kaliuresis. In the presence of GS, this compensatory mechanism is easily overwhelmed, resulting in profound hypokalemia. We present a case of an 18-year-old primigravida with undiagnosed GS who presented with hyperemesis gravidarum in her 7th week of pregnancy. This report adds to the limited experience with GS in pregnancy as reported in literature and provides additional information on medical management that leads to successful maternal and fetal outcomes.
authors: Department of Medicine, University of South Alabama, Mobile, AL 36617, USA.
authors: Maria Czarina
authors: 0000-0002-1607-6136
authors: MC
authors: Acelajado
authors: Department of Medicine, University of South Alabama, Mobile, AL 36617, USA.
authors: R Michael
authors: RM
authors: Culpepper
authors: Department of Medicine, University of South Alabama, Mobile, AL 36617, USA.
authors: Wilburn D
authors: WD
authors: Bolton Iii