title: Familial segregation of group B streptococcal infection in a consanguineous kindred.
abstract: Two cases of neonatal group B streptococcal (GBS) infection occurring in a large consanguineous kindred are described. The observation suggests that susceptibility to isolated GBS disease in this family may have been the result of an inborn error of immunity inherited as a Mendelian autosomal recessive trait.
authors: Immuno-rheumatology, Department of Paediatrics II, Regina Margherita Hospital, Città della Salute e della Scienza di Torino, Torino, Italy.
authors: Francesco
authors: F
authors: Licciardi
authors: Immuno-rheumatology, Department of Paediatrics II, Regina Margherita Hospital, Città della Salute e della Scienza di Torino, Torino, Italy.
authors: Davide
authors: D
authors: Montin
authors: Department of Emergency Paediatrics, Regina Margherita Hospital, Città della Salute e della Scienza di Torino, Torino, Italy.
authors: Antonia
authors: A
authors: Versace
authors: Department of Emergency Paediatrics, Regina Margherita Hospital, Città della Salute e della Scienza di Torino, Torino, Italy.
authors: Giuseppina
authors: G
authors: Migliore
authors: Neonatal Intensive Care Unit, San Matteo Hospital, Pavia, Italy.
authors: Chryssoula
authors: C
authors: Tzialla
authors: SIB Swiss Institute of Bioinformatics, Lausanne, Switzerland; School of Life Sciences, Global Health Institute, Laboratory of Professor Jacques Fellay, École Polytechnique Fédérale de Lausanne, Station 19, CH-1015 Lausanne, Switzerland.
authors: Jacques
authors: J
authors: Fellay
authors: Neonatal Intensive Care Unit, San Matteo Hospital, Pavia, Italy; SIB Swiss Institute of Bioinformatics, Lausanne, Switzerland; School of Life Sciences, Global Health Institute, Laboratory of Professor Jacques Fellay, École Polytechnique Fédérale de Lausanne, Station 19, CH-1015 Lausanne, Switzerland. Electronic address: alessandro.borghesi@epfl.ch.
authors: Alessandro
authors: A
authors: Borghesi
mesh_terms: D019072:Antibiotic Prophylaxis; D000907:Antibodies, Bacterial / Q000235:genetics / Q000276:immunology; D003241:Consanguinity; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D013290:Streptococcal Infections / Q000188:drug therapy / Q000235:genetics* / Q000276:immunology; D013292:Streptococcus agalactiae
chemical_list: D000907:Antibodies, Bacterial
keywords: GBS; Genetic; Mendelian; Neonatal; Primary immunodeficiency; Streptococcus agalactiae