title: Conjugated linoleic acid improves glycemic response, lipid profile, and oxidative stress in obese patients with non-alcoholic fatty liver disease: a randomized controlled clinical trial.
abstract: OBJECTIVE
  To investigate if conjugated linoleic acid supplementation (CLA) affects metabolic factors and oxidative stress in non-alcoholic fatty liver disease (NAFLD).
  
  
  METHODS
  The study was a randomized, controlled clinical trial conducted in specialized and subspecialized clinics of Tabriz University of Medical Sciences from January 2014 to March 2015. 38 obese NAFLD patients were randomly allocated into either the intervention group, receiving three 1000 mg softgel of CLA with a weight loss diet and 400 IU vitamin E, or into the control group, receiving only weight loss diet and 400 IU vitamin E for eight weeks. Dietary data and physical activity, as well as anthropometric, body composition, metabolic factors, and oxidative stress were assessed at baseline and at the end of the study.
  
  
  RESULTS
  Weight, body composition, and serum oxidative stress, insulin, and lipid profile significantly improved in both groups, while hemoglobin A1c (HbA1c) levels (P=0.004), total cholesterol to high density lipoprotein ratio (P=0.008), low density lipoprotein to high density lipoprotein ratio (LDL/HDL) (P=0.002), and alanine aminotransferase to aspartate aminotransferase (ALT/AST) ratio (P=0.025) significantly decreased in the intervention group. At the end of the study, fat mass (P=0.001), muscle mass (P=0.023), total body water (P=0.004), HbA1c (P<0.001), triglycerides (P=0.006), LDL/HDL ratio (P=0.027), and ALT/AST ratio (P=0.046) were significantly better in the CLA group than in the control group.
  
  
  CONCLUSIONS
  CLA improved insulin resistance, lipid disturbances, oxidative stress, and liver function in NAFLD. Therefore, it could be considered as an effective complementary treatment in NAFLD.
authors: Mehrangiz
authors: M
authors: Ebrahimi-Mameghani
authors: Haleh Jamali, Student Research Committee, School of Nutrition, Tabriz University of Medical Sciences, Golgasht St., Attar Neishaboori Av., 5166614711, Tabriz, Iran, Jamali.Haleh@gmail.com.
authors: Haleh
authors: H
authors: Jamali
authors: Reza
authors: R
authors: Mahdavi
authors: Farzad
authors: F
authors: Kakaei
authors: Rana
authors: R
authors: Abedi
authors: Bita
authors: B
authors: Kabir-Mamdooh
mesh_terms: D000328:Adult; D000410:Alanine Transaminase / Q000097:blood; D001219:Aspartate Aminotransferases / Q000097:blood; D001786:Blood Glucose / Q000378:metabolism; D001837:Body Weights and Measures; D004038:Diet, Reducing; D005260:Female; D006442:Glycated Hemoglobin / Q000378:metabolism; D006801:Humans; D007333:Insulin Resistance; D044243:Linoleic Acids, Conjugated / Q000627:therapeutic use*; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged; D065626:Non-alcoholic Fatty Liver Disease / Q000188:drug therapy* / Q000503:physiopathology*; D018384:Oxidative Stress / Q000187:drug effects*; D014810:Vitamin E / Q000008:administration & dosage
chemical_list: D000410:Alanine Transaminase; D001219:Aspartate Aminotransferases; D001786:Blood Glucose; D006442:Glycated Hemoglobin; D044243:Linoleic Acids, Conjugated; D008055:Lipids; D014810:Vitamin E