title: Quantitative quality assurance in a multicenter HARDI clinical trial at 3T.
abstract: A phantom-based quality assurance (QA) protocol was developed for a multicenter clinical trial including high angular resolution diffusion imaging (HARDI). A total of 27 3T MR scanners from 2 major manufacturers, GE (Discovery and Signa scanners) and Siemens (Trio and Skyra scanners), were included in this trial. With this protocol, agar phantoms doped to mimic relaxation properties of brain tissue are scanned on a monthly basis, and quantitative procedures are used to detect spiking and to evaluate eddy current and Nyquist ghosting artifacts. In this study, simulations were used to determine alarm thresholds for minimal acceptable signal-to-noise ratio (SNR). Our results showed that spiking artifact was the most frequently observed type of artifact. Overall, Trio scanners exhibited less eddy current distortion than GE scanners, which in turn showed less distortion than Skyra scanners. This difference was mainly caused by the different sequences used on these scanners. The SNR for phantom scans was closely correlated with the SNR from volunteers. Nearly all of the phantom measurements with artifact-free images were above the alarm threshold, suggesting that the scanners are stable longitudinally. Software upgrades and hardware replacement sometimes affected SNR substantially but sometimes did not. In light of these results, it is important to monitor longitudinal SNR with phantom QA to help interpret potential effects on in vivo measurements. Our phantom QA procedure for HARDI scans was successful in tracking scanner performance and detecting unwanted artifacts.
authors: Imaging Institute, Cleveland Clinic, Cleveland, OH, 44195, USA.
authors: Xiaopeng
authors: X
authors: Zhou
authors: Imaging Institute, Cleveland Clinic, Cleveland, OH, 44195, USA.
authors: Ken E
authors: KE
authors: Sakaie
authors: Barrow Neurological Institute, St. Joseph's Hospital and Medical Center, Phoenix, AZ, 85013,USA.
authors: Josef P
authors: JP
authors: Debbins
authors: Siemens Medical Solutions, Cary, NC, 27511, USA.
authors: John E
authors: JE
authors: Kirsch
authors: Department of Neurology, Case Western Reserve University, Cleveland, OH, 44106, USA.
authors: Curtis
authors: C
authors: Tatsuoka
authors: Neurological Institute, Cleveland Clinic, Cleveland, OH, 44195, USA.
authors: Robert J
authors: RJ
authors: Fox
authors: Imaging Institute, Cleveland Clinic, Cleveland, OH, 44195, USA. Electronic address: lowem1@ccf.org.
authors: Mark J
authors: MJ
authors: Lowe
mesh_terms: D000328:Adult; D016477:Artifacts; D001921:Brain / Q000033:anatomy & histology*; D001931:Brain Mapping / Q000379:methods / Q000592:standards; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods* / Q000592:standards*; D008297:Male; D008875:Middle Aged; D019047:Phantoms, Imaging; D011785:Quality Assurance, Health Care / Q000379:methods*; D059629:Signal-To-Noise Ratio; D055815:Young Adult
keywords: HARDI; Multicenter; Phantom; QA; SNR