title: Activity and safety of oral etoposide in pretreated patients with metastatic or recurrent thymic epithelial tumors (TET): A single-institution experience.
abstract: Standard regimens in pretreated advanced TETs are lacking. Single agent responses have been reported with pemetrexed, gemcitabine and targeted therapies. Oral etoposide monotherapy has a favorable safety and efficacy profile in other tumor types. We assessed its activity and safety in advanced or recurrent pretreated TETs.
  
  
  
  We conducted a retrospective analysis of patients with advance or recurrent TET treated with single agent oral etoposide at Gustave Roussy (GR) between 1992 and 2015. Efficacy analyses was made by treating physician according to RECIST and retrospectively collected from medical records. Kaplan-Meier method was used to estimate progression-free survival (PFS) and overall survival (OS).
  
  
  
  Twenty patients were included. Median age was 62 years [range 34-88], 60% were male, 25% had thymoma (T) and 75% had thymic carcinoma (TC). Myasthenia gravis was reported in 15% of them. A median of 2 [range 0-7] prior chemotherapy regimens had been administered, with 60% exposed to etoposide (VIP 40%, carboplatin-etoposide 15%, BEP 5%). Median follow-up since etoposide was 7 years [range 0.5-8.9]. Three patients achieved partial response and nine had stable disease, giving an overall response rate of 15% [T: 20%, TC: 13%] and a 60% disease control rate [T: 100%, TC: 46%]. Median PFS was 4 months [95%CI 3-14] and median OS was 41 months [95%CI 6-86]. Median PFS for T and TC were 21 months [95%CI 9-42] and 4 months [95%CI 2-4]; median OS were 99 months [95%CI 43-not reached] and 13 months [95%CI 4-41], respectively. The most common grade 3-4 related events occurred in 9 patients (45%) and were neutropenia followed by anemia and thrombocytopenia.
  
  
  
  Oral etoposide monotherapy is an active option for pretreated TET patients, with manageable toxicity profile.
authors: Department of Cancer Medicine, Gustave Roussy, Villejuif, France.
authors: M V
authors: MV
authors: Bluthgen
authors: Department of Cancer Medicine, Gustave Roussy, Villejuif, France.
authors: C
authors: C
authors: Boutros
authors: Department of Biostatistics and Epidemiology, Gustave Roussy, Villejuif, France; CESP, INSERM, Univ. Paris-Sud, UVSQ, Université Paris-Saclay, Villejuif, France; Université Paris-Sud, 15 Rue Georges Clemenceau, 91400 Orsay, France.
authors: F
authors: F
authors: Fayard
authors: Department of Cancer Medicine, Gustave Roussy, Villejuif, France.
authors: J
authors: J
authors: Remon
authors: Department of Cancer Medicine, Gustave Roussy, Villejuif, France.
authors: D
authors: D
authors: Planchard
authors: Department of Cancer Medicine, Gustave Roussy, Villejuif, France; Université Paris-Sud, 15 Rue Georges Clemenceau, 91400 Orsay, France. Electronic address: Benjamin.BESSE@gustaveroussy.fr.
authors: B
authors: B
authors: Besse
mesh_terms: D000284:Administration, Oral; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage* / Q000009:adverse effects; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use; D005047:Etoposide / Q000008:administration & dosage* / Q000009:adverse effects; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis; D009367:Neoplasm Staging; D009375:Neoplasms, Glandular and Epithelial / Q000188:drug therapy* / Q000401:mortality / Q000473:pathology*; D012008:Recurrence; D019233:Retreatment; D012189:Retrospective Studies; D013953:Thymus Neoplasms / Q000188:drug therapy* / Q000401:mortality / Q000473:pathology*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D005047:Etoposide
keywords: Advanced thymic epithelial tumors; Etoposide; Recurrence; Single agent