title: Drug nanocarrier, the future of atopic diseases: Advanced drug delivery systems and smart management of disease.
abstract: Atopic dermatitis (AD) is a chronically relapsing skin inflammatory disorder characterized by perivascular infiltration of immunoglobulin-E (IgE), T-lymphocytes and mast cells. The key pathophysiological factors causing this disease are immunological disorders and the compromised epidermal barrier integrity. Pruritus, intense itching, psychological stress, deprived physical and mental performance and sleep disturbance are the hallmark features of this dermatological complication. Preventive interventions which include educational programs, avoidance of allergens, exclusive care towards skin, and the rational selection of therapeutic regimen play key roles in the treatment of dermatosis. In last two decades, it is evident from a plethora of studies that scientific focus is being driven from conventional therapies to the advanced nanocarrier-based regimen for an effective management of AD. These nanocarriers which include polymeric nanoparticles (NPs), hydrogel NPs, liposomes, ethosomes, solid lipid nanoparticles (SLNs) and nanoemulsion, provide efficient roles for the target specific delivery of the therapeutic payload. The success of these targeted therapies is due to their pharmaceutical versatility, longer retention time at the target site, avoiding off-target effects and preventing premature degradation of the incorporated drugs. The present review was therefore aimed to summarise convincing evidence for the therapeutic superiority of advanced nanocarrier-mediated strategies over the conventional therapies used in the treatment of AD.
authors: Department of Pharmaceutical Engineering, School of Chemistry, Chemical Engineering and Life Science, Wuhan University of Technology, 205 Luoshi Road, Wuhan, 430070, PR China.
authors: Mei
authors: M
authors: Shao
authors: Faculty of Pharmacy, Universiti Teknologi MARA, Puncak Alam Campus, Bandar Puncak Alam, 42300, Selangor, Malaysia. Electronic address: zahidh8589@gmail.com.
authors: Zahid
authors: Z
authors: Hussain
authors: Department of Pharmacology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Yaacob Latif, Bandar Tun Razak, 56000, Cheras, Kuala Lumpur, Malaysia.
authors: Hnin Ei
authors: HE
authors: Thu
authors: Department of Pharmacy, University of Malakand, Chakdara, Dir (L), KPK, Pakistan.
authors: Shahzeb
authors: S
authors: Khan
authors: Centre for Drug Delivery Research, Faculty of Pharmacy, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300, Kuala Lumpur, Malaysia.
authors: Haliza
authors: H
authors: Katas
authors: Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, King Abdulaziz University, Jeddah, Saudi Arabia.
authors: Tarek A
authors: TA
authors: Ahmed
authors: Faculty of Pharmacy, Universiti Teknologi MARA, Puncak Alam Campus, Bandar Puncak Alam, 42300, Selangor, Malaysia.
authors: Minaketan
authors: M
authors: Tripathy
authors: Department of Pharmaceutical Engineering, School of Chemistry, Chemical Engineering and Life Science, Wuhan University of Technology, 205 Luoshi Road, Wuhan, 430070, PR China.
authors: Jing
authors: J
authors: Leng
authors: Department of Pharmaceutical Engineering, School of Chemistry, Chemical Engineering and Life Science, Wuhan University of Technology, 205 Luoshi Road, Wuhan, 430070, PR China. Electronic address: qinhuali@whut.edu.cn.
authors: Hua-Li
authors: HL
authors: Qin
authors: Department of Pharmaceutical Engineering, School of Chemistry, Chemical Engineering and Life Science, Wuhan University of Technology, 205 Luoshi Road, Wuhan, 430070, PR China.
authors: Syed Nasir Abbas
authors: SNA
authors: Bukhari
mesh_terms: D003876:Dermatitis, Atopic / Q000188:drug therapy*; D019468:Disease Management; D004337:Drug Carriers / Q000008:administration & dosage* / Q000737:chemistry; D016503:Drug Delivery Systems; D006801:Humans; D050997:Nanomedicine / Q000639:trends*
chemical_list: D004337:Drug Carriers
keywords: Advanced nanocarrier-based therapies; Atopic dermatitis; Ethosomes; Liposomes; Nanoemulsion; Polymeric nanoparticles; Solid lipid nanoparticles