title: Dynamics of Structural Parameters and Accumulation of Collagen Fibrils in Rat Lung after Inhalations of Surfactant-BL at Various Terms of Bleomycin-Induced Alveolitis.
abstract: Rats were subjected to surfactant-BL inhalations at the early and late phases of bleomycininduced alveolitis. In both regimens, the drug reduced the severity of inflammation. In the acute phase of alveolitis, the therapeutic effect of inhalation was accompanied by activation of the synthesis of fine lose collagen fibrils. In the late phase of alveolitis, inhalation of surfactant-BL thickened the fibrils and diminished their population in alveolar walls.
authors: Russian Research Center of Radiology and Surgical Technologies, Ministry of Health of the Russian Federation, St. Petersburg, Russia. volchkov@biosurf.ru.
authors: V A
authors: VA
authors: Volchkov
authors: Russian Research Center of Radiology and Surgical Technologies, Ministry of Health of the Russian Federation, St. Petersburg, Russia.
authors: V F
authors: VF
authors: Dubrovskaya
authors: Russian Research Center of Radiology and Surgical Technologies, Ministry of Health of the Russian Federation, St. Petersburg, Russia.
authors: A A
authors: AA
authors: Valkovich
authors: Russian Research Center of Radiology and Surgical Technologies, Ministry of Health of the Russian Federation, St. Petersburg, Russia.
authors: O V
authors: OV
authors: Klestova
authors: Russian Research Center of Radiology and Surgical Technologies, Ministry of Health of the Russian Federation, St. Petersburg, Russia.
authors: V A
authors: VA
authors: Serzhanina
authors: Russian Research Center of Radiology and Surgical Technologies, Ministry of Health of the Russian Federation, St. Petersburg, Russia.
authors: A G
authors: AG
authors: Zhuikov
authors: Russian Research Center of Radiology and Surgical Technologies, Ministry of Health of the Russian Federation, St. Petersburg, Russia.
authors: A A
authors: AA
authors: Seiliev
authors: Russian Research Center of Radiology and Surgical Technologies, Ministry of Health of the Russian Federation, St. Petersburg, Russia.
authors: O A
authors: OA
authors: Rosenberg
mesh_terms: D000818:Animals; D001761:Bleomycin / Q000633:toxicity*; D003094:Collagen / Q000378:metabolism*; D008168:Lung / Q000187:drug effects / Q000378:metabolism* / Q000473:pathology*; D008297:Male; D011650:Pulmonary Alveoli / Q000187:drug effects / Q000378:metabolism* / Q000473:pathology*; D011663:Pulmonary Surfactants / Q000633:toxicity*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D011663:Pulmonary Surfactants; D001761:Bleomycin; D003094:Collagen
keywords: bleomycin; collagen fibrils; lung; rats; surfactant-BL