title: Resurgence of Ebola Virus Disease in Guinea Linked to a Survivor With Virus Persistence in Seminal Fluid for More Than 500 Days.
abstract: We report on an Ebola virus disease (EVD) survivor who showed Ebola virus in seminal fluid 531 days after onset of disease. The persisting virus was sexually transmitted in February 2016, about 470 days after onset of symptoms, and caused a new cluster of EVD in Guinea and Liberia.
authors: World Health Organization, Conakry, Guinea.
authors: Boubacar
authors: B
authors: Diallo
authors: INSERM U1219, Bordeaux University.|Bordeaux University Hospital, France.
authors: Daouda
authors: D
authors: Sissoko
authors: Institute of Microbiology and Infection, University of Birmingham, United Kingdom.
authors: Nicholas J
authors: NJ
authors: Loman
authors: Laboratoire des Fièvres Hémorragiques en Guinée, Hôpital Donka et N'Zérékoré.
authors: Hadja Aïssatou
authors: HA
authors: Bah
authors: World Health Organization, Conakry, Guinea.
authors: Hawa
authors: H
authors: Bah
authors: Centers for Disease Control and Prevention (CDC) Guinea Response Team, Conakry.|Center for Global Health, CDC, Atlanta, Georgia.
authors: Mary Claire
authors: MC
authors: Worrell
authors: World Health Organization, Conakry, Guinea.
authors: Lya Saidou
authors: LS
authors: Conde
authors: World Health Organization, Conakry, Guinea.
authors: Ramata
authors: R
authors: Sacko
authors: World Health Organization, Conakry, Guinea.
authors: Samuel
authors: S
authors: Mesfin
authors: World Health Organization, Conakry, Guinea.
authors: Angelo
authors: A
authors: Loua
authors: Centers for Disease Control and Prevention (CDC) Guinea Response Team, Conakry.
authors: Jacques Katomba
authors: JK
authors: Kalonda
authors: Centers for Disease Control and Prevention (CDC) Guinea Response Team, Conakry.
authors: Ngozi A
authors: NA
authors: Erondu
authors: Centers for Disease Control and Prevention (CDC) Guinea Response Team, Conakry.|Center for Global Health, CDC, Atlanta, Georgia.
authors: Benjamin A
authors: BA
authors: Dahl
authors: European Mobile Laboratory Consortium.|Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany.
authors: Susann
authors: S
authors: Handrick
authors: Division of Virology, Department of Pathology, University of Cambridge, Addenbrooke's Hospital, United Kingdom.|Department of Public Health, University of Makeni, Sierra Leone.
authors: Ian
authors: I
authors: Goodfellow
authors: Division of Virology, Department of Pathology, University of Cambridge, Addenbrooke's Hospital, United Kingdom.|Department of Public Health, University of Makeni, Sierra Leone.
authors: Luke W
authors: LW
authors: Meredith
authors: Wellcome Genome Campus, Hinxton, Cambridge, United Kingdom.
authors: Matthew
authors: M
authors: Cotten
authors: Department of Public Health, University of Makeni, Sierra Leone.
authors: Umaru
authors: U
authors: Jah
authors: Department of Public Health, University of Makeni, Sierra Leone.|Department of Biology, University of Rome II "Tor Vergata," Italy.
authors: Raoul Emeric
authors: RE
authors: Guetiya Wadoum
authors: Centers for Disease Control and Prevention (CDC) Guinea Response Team, Conakry.|National Center for Emerging and Zoonotic Infectious Diseases, CDC, Atlanta, Georgia.
authors: Pierre
authors: P
authors: Rollin
authors: Université Gamal Abdel Nasser de Conakry, Laboratoire des Fièvres Hémorragiques en Guinée, Guinea.
authors: N'Faly
authors: N
authors: Magassouba
authors: INSERM U1219, Bordeaux University.|Bordeaux University Hospital, France.
authors: Denis
authors: D
authors: Malvy
authors: INSERM U1219, Bordeaux University.|Programme ANRS Coopération Côte d'Ivoire, Agence Nationale de Recherche sur le Sida Research Site, Treichville University Hospital, Abidjan, Côte d'Ivoire.
authors: Xavier
authors: X
authors: Anglaret
authors: European Mobile Laboratory Consortium.|Public Health England, Porton Down, Salisbury.|University of Southampton, South General Hospital, United Kingdom.
authors: Miles W
authors: MW
authors: Carroll
authors: World Health Organization, Geneva, Switzerland.
authors: Raymond Bruce
authors: RB
authors: Aylward
authors: World Health Organization, Conakry, Guinea.
authors: Mamoudou Harouna
authors: MH
authors: Djingarey
authors: World Health Organization, Conakry, Guinea.
authors: Abdoulaye
authors: A
authors: Diarra
authors: World Health Organization, Geneva, Switzerland.
authors: Pierre
authors: P
authors: Formenty
authors: Ministry of Health, Conakry, Guinea.
authors: Sakoba
authors: S
authors: Keïta
authors: European Mobile Laboratory Consortium.|Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany.
authors: Stephan
authors: S
authors: Günther
authors: Institute for Evolutionary Biology, Centre for Infection, Immunity and Evolution, Ashworth Laboratories, University of Edinburgh, United Kingdom.
authors: Andrew
authors: A
authors: Rambaut
authors: European Mobile Laboratory Consortium.|Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany.
authors: Sophie
authors: S
authors: Duraffour
mesh_terms: D004196:Disease Outbreaks; D029043:Ebolavirus / Q000235:genetics* / Q000302:isolation & purification; D005260:Female; D016701:Guinea; D019142:Hemorrhagic Fever, Ebola / Q000635:transmission / Q000821:virology; D006801:Humans; D008297:Male; D016133:Polymerase Chain Reaction; D012367:RNA, Viral / Q000032:analysis; D012661:Semen / Q000821:virology*; D015229:Sexually Transmitted Diseases, Viral / Q000635:transmission / Q000821:virology; D017741:Survivors
chemical_list: D012367:RNA, Viral
keywords: Ebola virus; Ebola virus persistence; real-time sequencing; seminal fluid; sexual transmission