title: Urease inhibition potential of Di-naphthodiospyrol from Diospyros lotus roots.
abstract: The dimeric napthoquione 5,8,4'-trihydroxy-1'-methoxy-6, 6'-dimethyl-7,3'-binaphtyl-1,4,5',8'-tetraone (1) was isolated from the chloroform fraction of Diospyros lotus extract. Compound 1 was screened for its inhibitory effects against four enzymes: urease, phosphodiesterase-I, carbonic anhydrase-II and α-chymotrypsin, and showed selective activity against urease enzyme with an IC50value of 254.1 ± 3.82 μM as compared to the standard thiourea (IC50= 21 ± 0.11 μM). Furthermore, in silico docking study was carried out to explain the molecular mechanism of compound 1 against the target receptor.
authors: a Department of Geology , University of Swabi , Anbar , Pakistan.
authors: Abdur
authors: A
authors: Rauf
authors: b Institute of Chemical Sciences, University of Peshawar , Peshawar , Pakistan.
authors: Ghias
authors: G
authors: Uddin
authors: c State Key Laboratory of Chemical Resource Engineering , Beijing University of Chemical Technology , Beijing , China.
authors: Muslam
authors: M
authors: Raza
authors: d Bioinformatics and Medical Informatics Research Center, San Diego State University , San Diego , CA , USA.
authors: Seema
authors: S
authors: Patel
authors: e Faculty of Pharmacy, Department of Pharmaceutical Chemistry , Umm Al-Qura University , Makkah , Saudi Arabia.
authors: Saud
authors: S
authors: Bawazeer
authors: f LCM Laboratory, Faculty of Sciences , University of Mohamed 1st , Oujda , Morocco.
authors: Taibi
authors: T
authors: Ben Hadda
authors: a Department of Geology , University of Swabi , Anbar , Pakistan.
authors: Noor
authors: N
authors: Jehan
authors: g Department of Chemistry , College of Science, King Saud University , Riyadh , Saudi Arabia.
authors: Yahia Nasser
authors: YN
authors: Mabkhot
authors: h Department of Chemistry, COMSATS Institute of Information Technology , Abbottabad , Pakistan.
authors: Ajmal
authors: A
authors: Khan
authors: i Department of Chemistry , The University of Jordan , Amman 11942 , Jordan.
authors: Mohammad S
authors: MS
authors: Mubarak
mesh_terms: D002918:Chymotrypsin / Q000037:antagonists & inhibitors; D029788:Diospyros / Q000737:chemistry*; D062105:Molecular Docking Simulation; D009285:Naphthoquinones / Q000737:chemistry / Q000494:pharmacology*; D010936:Plant Extracts / Q000032:analysis; D018517:Plant Roots / Q000737:chemistry; D014510:Urease / Q000037:antagonists & inhibitors*
chemical_list: D009285:Naphthoquinones; D010936:Plant Extracts; C000616097:di-naphthodiospyrol; D002918:Chymotrypsin; C117608:alpha-chymotrypsin; D014510:Urease
keywords: Diospyros lotus; Ebenaceae; di-naphthodiospyrol M; molecular docking; urease inhibitory activity