title: Genetics of gestational diabetes mellitus.
abstract: Gestational diabetes mellitus (GDM) has now become a major public health problem because of its prevalence and its associated complications during pregnancy. Earlier studies have suggested that type 2 diabetes mellitus (T2DM) and GDM might have similar pathophysiology, such as increased insulin resistance, decreased insulin secretion resulting in hyperglycaemia. Evidence for a genetic basis of GDM has been poorly understood. To some extent, the current advancement in genomic techniques has thrown better light on the genetics of GDM. Based on the candidate gene approach and genome wide association studies, genetic loci in several genes that are responsible for insulin secretion, insulin resistance, lipid and glucose metabolism and other pathways have shown association with the GDM susceptibility. Understanding the possible underlying genetic factors of GDM would help us in gaining knowledge on the pathophysiologic mechanism of the disease.
authors: Madras Diabetes Research Foundation, WHO Collaborating Centre for Noncommunicable Diseases Prevention and Control, Chennai, India.
authors: Venkatesan
authors: V
authors: Radha
authors: Madras Diabetes Research Foundation, WHO Collaborating Centre for Noncommunicable Diseases Prevention and Control, Chennai, India.
authors: Sekar
authors: S
authors: Kanthimathi
authors: Madras Diabetes Research Foundation, WHO Collaborating Centre for Noncommunicable Diseases Prevention and Control, Chennai, India and Dr. Mohan's Diabetes Specialities Centre, WHO Collaborating Centre for Noncommunicable Diseases Prevention and Control, Chennai, India.
authors: Ranjit Mohan
authors: RM
authors: Anjana
authors: Madras Diabetes Research Foundation, WHO Collaborating Centre for Noncommunicable Diseases Prevention and Control, Chennai, India and Dr. Mohan's Diabetes Specialities Centre, WHO Collaborating Centre for Noncommunicable Diseases Prevention and Control, Chennai, India.
authors: Viswanathan
authors: V
authors: Mohan
mesh_terms: D003924:Diabetes Mellitus, Type 2; D016640:Diabetes, Gestational / Q000235:genetics*; D005260:Female; D055106:Genome-Wide Association Study; D006801:Humans; D006943:Hyperglycemia / Q000235:genetics; D007333:Insulin Resistance / Q000235:genetics; D011247:Pregnancy
keywords: GDM, CDKAL1, HKDC1, HMG20A, HNF4A.