title: The range of peripapillary retinal nerve fibre layer and optic disc parameters, in children aged up to but not including 18 years of age who were born prematurely: protocol for a systematic review.
abstract: The parameters of the optic disc and peripapillary retinal nerve fibre layer (pRNFL) in premature children may vary with disease processes that contribute to visual impairment and blindness and so could be useful as an objective measure in at-risk children.
  
  
  
  A systematic review of current literature on the range of pRNFL and optic disc parameters in children aged less than 18 years, who were born before 37 weeks gestation, will be performed. The bibliographic databases MEDLINE, CINAHL, EMBASE, Scopus and Web of Science will be systematically searched. Where possible and appropriate, study-specific estimates will be combined using meta-analysis to obtain an overall summary estimate of pRNFL thickness and cup-disc ratio across studies, and results will be presented by age of population.
  
  
  
  This review aims to improve understanding of what might be considered within/outside the range of normality for this high-risk group.
  
  
  
  The review is registered on
  
  
  
  CRD42016037933.
authors: MRC Integrative Epidemiology Unit, School of Social and Community Medicine, University of Bristol, Oakfield House, Oakfield Grove Clifton, Bristol, BS8 2BN, UK. Alexandra.creavin@bristol.ac.uk.|Centre for Child and Adolescent Health, School of Social and Community Medicine, University of Bristol, Bristol, UK. Alexandra.creavin@bristol.ac.uk.
authors: Alexandra L
authors: AL
authors: Creavin
authors: Centre for Child and Adolescent Health, School of Social and Community Medicine, University of Bristol, Bristol, UK.
authors: Cathy E M
authors: CE
authors: Williams
authors: MRC Integrative Epidemiology Unit, School of Social and Community Medicine, University of Bristol, Oakfield House, Oakfield Grove Clifton, Bristol, BS8 2BN, UK.
authors: Kate
authors: K
authors: Tilling
authors: School of Clinical Sciences, University of Bristol, Bristol, UK.
authors: Karen
authors: K
authors: Luyt
authors: MRC Integrative Epidemiology Unit, School of Social and Community Medicine, University of Bristol, Oakfield House, Oakfield Grove Clifton, Bristol, BS8 2BN, UK.
authors: Nicholas
authors: N
authors: Timpson
authors: MRC Integrative Epidemiology Unit, School of Social and Community Medicine, University of Bristol, Oakfield House, Oakfield Grove Clifton, Bristol, BS8 2BN, UK.
authors: Julian P T
authors: JP
authors: Higgins
mesh_terms: D006801:Humans; D009412:Nerve Fibers; D009898:Optic Disk / Q000033:anatomy & histology* / Q000000981:diagnostic imaging*; D047928:Premature Birth; D012016:Reference Values; D012160:Retina / Q000033:anatomy & histology* / Q000000981:diagnostic imaging*; D000078202:Systematic Reviews as Topic; D041623:Tomography, Optical Coherence
keywords: Ophthalmology; Optic nerve; Optical coherence tomography (OCT); Paediatrics/pediatrics; Premature/prematurity; Retinal nerve fibre layer/retinal nerve fiber layer