title: Novel Use of Ex Vivo Uretero-Pyeloscopy in Autotransplantation: A Systematic Review and Case Report.
abstract: BACKGROUND
  Autotransplant has been practiced for decades but is regaining popularity in the nephron-sparing era. Initially for benign disease, autotransplantation has a select role in malignant processes that warrants new techniques and ideas to ensure patient safety. We review the use of ex vivo uretero-pyeloscopy and frozen section to ensure kidneys may be utilized in a patient with suspected malignancy.
  
  
  METHODS
  A systematic review (PRISMA standard) of ex vivo uretreo-pyeloscopy was undertaken. We then present the case of a 37-year-old Caucasian female who was suspected of having ureteral obstructing malignancy; she had previous treatment of the bladder with bacillus Calmette-Guerin (BCG) for recurrent urothelial malignancy. The lesion biopsies and cytology were suspicious but inconclusive, indicating nephroureterectomy was a likely course of management.
  
  
  RESULTS
  On reviewing the literature, we found that the use of ex vivo uretero-pyeloscopy has been described for urolithiasis to remove stones before transplantation but not specifically to exclude malignancy. Ultimately, in this case, the patient underwent a renal autotransplantation for obstruction that was caused by a granuloma on the background of the previous BCG treatment. Intraoperatively, ex vivo uretero-pyeloscopy and frozen section were crucial in guiding this case by allowing for appropriate identification and resection of the ureteral lesion. In addition, the preservation of ureteral length allowed for autotransplantation, which remains effective at follow-up.
  
  
  CONCLUSIONS
  Ex vivo urteroscopy has been used effectively in donor kidneys to treat urolithiasis with minimal complications. We believe that this is the first documented case of ex vivo uretero-pyeloscopy being used effectively in renal autotransplantation to exclude urothelial malignancy.
authors: Urology Unit, Department of Surgery, University of Melbourne , Melbourne, Australia .
authors: Trevor
authors: T
authors: Tnay
authors: Urology Unit, Department of Surgery, University of Melbourne , Melbourne, Australia .
authors: Sandra
authors: S
authors: Elmer
authors: Urology Unit, Department of Surgery, University of Melbourne, Melbourne, Australia.; Austin Hospital, Olivia Newton-John Cancer Research Institute, Heidelberg, Australia.
authors: Damien M
authors: DM
authors: Bolton
authors: Urology Unit, Department of Surgery, University of Melbourne, Melbourne, Australia.; Austin Hospital, Olivia Newton-John Cancer Research Institute, Heidelberg, Australia.
authors: Nathan
authors: N
authors: Lawrentschuk