title: Levels of CD40L and other inflammatory biomarkers in obese and non-obese women with polycystic ovary syndrome.
abstract: We investigated whether changes in sCD40L, hs-CRP, IL-6, and TNF-α levels are associated with polycystic ovary syndrome (PCOS).
  
  
  
  Case-control study involving 143 women with and 165 women without PCOS.
  
  
  
  Reduced sCD40L, and increased hs-CRP and IL-6, but not TNF-α, levels were seen between cases and controls. ROC analysis demonstrated high sensitivity and specificity for sCD40L and hs-CRP as PCOS predictors. Altered sCD40L levels were associated with PCOS, irrespective of body weight. Significant differences in IL-6 levels were seen between non-obese subjects and for TNF-α in obese subjects. sCD40L correlated negatively with age, insulin, HOMA-IR, LH, free testosterone, FAI, and hirsutism, but positively with SHBG. CRP correlated positively with BMI, insulin, HOMA-IR, free testosterone, and hirsutism. IL-6 correlated positively with hirsutism. TNF-α correlated positively with age, but negatively with insulin and HOMA-IR.
  
  
  
  CD40L, more than IL-6, or TNF-α, constitutes a predictor to explain PCOS and associated features.
authors: Department of Medical Biochemistry, Arabian Gulf University, Manama, Bahrain. samehmss@agu.edu.bh.
authors: Sameh
authors: S
authors: Sarray
authors: Department of Medical Biochemistry, Arabian Gulf University, Manama, Bahrain.
authors: Wassim Y
authors: WY
authors: Almawi
mesh_terms: D000328:Adult; D002097:C-Reactive Protein / Q000378:metabolism; D023201:CD40 Ligand / Q000097:blood*; D016022:Case-Control Studies; D015536:Down-Regulation; D005260:Female; D006801:Humans; D018836:Inflammation Mediators / Q000378:metabolism; D015850:Interleukin-6 / Q000378:metabolism; D009765:Obesity / Q000150:complications / Q000175:diagnosis / Q000276:immunology*; D011085:Polycystic Ovary Syndrome / Q000150:complications / Q000276:immunology*; D011379:Prognosis; D012680:Sensitivity and Specificity; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism; D015854:Up-Regulation
chemical_list: D018836:Inflammation Mediators; D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha; D023201:CD40 Ligand; D002097:C-Reactive Protein
keywords: CD40L; CRP; cytokines; polycystic ovary syndrome