title: Bioaccumulation, Depuration, and Transfer to Offspring of13C-Labeled Fullerenols by Daphnia magna.
abstract: Fullerenols have wide application in the field of life sciences as a result of their extensive biocompatibility and biofunctionality. However, their environmental fate and ecotoxicological risks are largely unknown. In this study, stable isotope (13C) labeling was applied to investigate the bioaccumulation and depuration of fullerenols in Daphnia magna. By incorporation of13C on the skeleton of fullerenols, the concentrations of fullerenols in the samples could be precisely determined on the basis of carbon isotope ratios (13C/12C). After exposure to13C-labeled fullerenols in artificial freshwater for 48 h, the steady concentrations of fullerenols in D. magna were nearly 0.39 and 1.37% of the dry body weight in the 0.1 and 1.0 mg/L exposure groups, respectively. After 48 h of depuration, D. magna could excrete 97.34 and 89.56% of the accumulated fullerenols in 0.1 and 1.0 mg/L exposure group, respectively. The depuration of fullerenols from D. magna followed first-order kinetics. Moreover, accumulated fullerenols in gravid D. magna could be transferred to the next generation of neonates. The results in present study demonstrated that stable isotope (13C) labeling is a powerful tool to investigate the environmental fate and the potential impacts of fullerenols in ecological systems.
authors: Key Laboratory of Urban Environment and Health, Institute of Urban Environment, Chinese Academy of Sciences , Xiamen, Fujian 361021, People's Republic of China.
authors: Miaomiao
authors: M
authors: Du
authors: Key Laboratory of Urban Environment and Health, Institute of Urban Environment, Chinese Academy of Sciences , Xiamen, Fujian 361021, People's Republic of China.
authors: Han
authors: H
authors: Zhang
authors: Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences , Beijing 100049, People's Republic of China.|Key Laboratory of Catalysis and Materials Science, South-Central University for Nationalities , Wuhan, Hubei 430074, People's Republic of China.
authors: Jiaxin
authors: J
authors: Li
authors: Key Laboratory of Urban Environment and Health, Institute of Urban Environment, Chinese Academy of Sciences , Xiamen, Fujian 361021, People's Republic of China.
authors: Changzhou
authors: C
authors: Yan
authors: Key Laboratory of Urban Environment and Health, Institute of Urban Environment, Chinese Academy of Sciences , Xiamen, Fujian 361021, People's Republic of China.
authors: Xian
authors: X
authors: Zhang
authors: Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences , Beijing 100049, People's Republic of China.
authors: Xueling
authors: X
authors: Chang
mesh_terms: D000818:Animals; D003621:Daphnia / Q000378:metabolism*; D005618:Fresh Water; D007700:Kinetics; D014874:Water Pollutants, Chemical
chemical_list: D014874:Water Pollutants, Chemical