title: Comparison of Characteristics and Outcomes of Heart Failure Patients With Preserved Versus Reduced Ejection Fraction in a Multiethnic Southeast Asian Cohort.
abstract: There are few data comparing the patient characteristics and outcomes of heart failure with preserved ejection fraction (HFpEF) and heart failure with reduced EF (HFrEF) in Asian cohorts. We aimed to evaluate the prevalence, clinical characteristics, and 1-year outcomes of a well-defined Southeast Asian HFpEF cohort in comparison to an HFrEF cohort. We conducted a retrospective observational study of 1,978 patients discharged from Changi General Hospital, Singapore with a primary diagnosis of HF from 2009 to 2013. About 29% of discharges had HFpEF. Patients with HFpEF were more likely to be women, older age, and have a higher prevalence of hypertension. There were no significant differences in the absolute rates of 30-day outcomes between the 2 groups. The absolute rate of death at 1 year was similar in HFrEF and HFpEF at 17% and 15%, respectively (p = 0.3). After multivariate adjustment, there was no difference in the outcomes of the 2 groups. Atrial fibrillation at baseline was a predictor of death or HF hospitalization in HFpEF but not HFrEF (interaction p = 0.003). In conclusion, in this study of a Southeast Asian population with well-defined HF, we found that the clinical profile of patients with HF was similar to that in the West and 30-day and 1-year mortality and morbidity were not significantly different between cohorts.
authors: Department of Cardiology, Changi General Hospital, Singapore, Singapore. Electronic address: Michael_ross_macdonald@cgh.com.sg.
authors: Michael Ross
authors: MR
authors: MacDonald
authors: Department of Cardiology, Changi General Hospital, Singapore, Singapore.
authors: Pang Ping
authors: PP
authors: Wee
authors: Department of Cardiology, Changi General Hospital, Singapore, Singapore.
authors: Yan
authors: Y
authors: Cao
authors: Department of Cardiology, Changi General Hospital, Singapore, Singapore.
authors: Dong Mei
authors: DM
authors: Yang
authors: Department of Cardiology, Changi General Hospital, Singapore, Singapore.
authors: Sheldon
authors: S
authors: Lee
authors: Department of Cardiology, Changi General Hospital, Singapore, Singapore.
authors: Khim Leng
authors: KL
authors: Tong
authors: Department of Cardiology, Changi General Hospital, Singapore, Singapore.
authors: Kui Toh Gerard
authors: KT
authors: Leong
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001210:Asia, Southeastern; D044466:Asian People; D001281:Atrial Fibrillation / Q000453:epidemiology; D002423:Cause of Death; D015331:Cohort Studies; D015897:Comorbidity; D004452:Echocardiography; D005260:Female; D006333:Heart Failure / Q000097:blood / Q000000981:diagnostic imaging / Q000453:epidemiology / Q000503:physiopathology*; D006760:Hospitalization / Q000706:statistics & numerical data*; D006801:Humans; D006973:Hypertension / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D009026:Mortality; D015999:Multivariate Analysis; D020097:Natriuretic Peptide, Brain / Q000097:blood; D010446:Peptide Fragments / Q000097:blood; D011379:Prognosis; D012189:Retrospective Studies; D012737:Sex Factors; D012846:Singapore; D013318:Stroke Volume
chemical_list: D010446:Peptide Fragments; C109794:pro-brain natriuretic peptide (1-76); D020097:Natriuretic Peptide, Brain