title: Comparison of a pediatric-inspired treatment protocol versus standard-intensity chemotherapy for young adults with standard-risk BCR-ABL negative acute lymphoblastic leukemia.
abstract: We investigated the utility of a pediatric-inspired protocol in adults aged 18-40 years with standard-risk BCR-ABL negative acute lymphoblastic leukemia (ALL). Retrospective outcomes of 25 patients treated with a pediatric protocol between 2008 and 2014 were compared with 22 similarly aged patients treated with an adult protocol between 2003 and 2008. Twenty-five (100%) and 19 (86%) patients achieved complete remission, respectively. At median follow-up of 36.8 months, 3-year event-free survival was increased in patients on the pediatric protocol at 80% versus 45% (p = .019). There was a trend toward improved overall survival at 80% versus 59% (p = .12). Treatment-related toxicity was not increased despite the increased treatment intensity. Patients with BCR and/or ABL copy number variation demonstrated comparatively poorer outcomes in both cohorts. In our experience with this cohort of patients, pediatric-based protocols are safe and effective, justifying their use in younger adults with ALL.
authors: a Leukemia/BMT Program of British Columbia, Division of Hematology , Vancouver General Hospital, University of British Columbia , Vancouver , BC , Canada.
authors: David
authors: D
authors: Kliman
authors: a Leukemia/BMT Program of British Columbia, Division of Hematology , Vancouver General Hospital, University of British Columbia , Vancouver , BC , Canada.
authors: Michael
authors: M
authors: Barnett
authors: a Leukemia/BMT Program of British Columbia, Division of Hematology , Vancouver General Hospital, University of British Columbia , Vancouver , BC , Canada.
authors: Raewyn
authors: R
authors: Broady
authors: a Leukemia/BMT Program of British Columbia, Division of Hematology , Vancouver General Hospital, University of British Columbia , Vancouver , BC , Canada.
authors: Donna
authors: D
authors: Forrest
authors: a Leukemia/BMT Program of British Columbia, Division of Hematology , Vancouver General Hospital, University of British Columbia , Vancouver , BC , Canada.
authors: Alina
authors: A
authors: Gerrie
authors: a Leukemia/BMT Program of British Columbia, Division of Hematology , Vancouver General Hospital, University of British Columbia , Vancouver , BC , Canada.
authors: Donna
authors: D
authors: Hogge
authors: a Leukemia/BMT Program of British Columbia, Division of Hematology , Vancouver General Hospital, University of British Columbia , Vancouver , BC , Canada.
authors: Stephen
authors: S
authors: Nantel
authors: a Leukemia/BMT Program of British Columbia, Division of Hematology , Vancouver General Hospital, University of British Columbia , Vancouver , BC , Canada.
authors: Sujaatha
authors: S
authors: Narayanan
authors: a Leukemia/BMT Program of British Columbia, Division of Hematology , Vancouver General Hospital, University of British Columbia , Vancouver , BC , Canada.
authors: Thomas
authors: T
authors: Nevill
authors: a Leukemia/BMT Program of British Columbia, Division of Hematology , Vancouver General Hospital, University of British Columbia , Vancouver , BC , Canada.
authors: Maryse
authors: M
authors: Power
authors: a Leukemia/BMT Program of British Columbia, Division of Hematology , Vancouver General Hospital, University of British Columbia , Vancouver , BC , Canada.
authors: David
authors: D
authors: Sanford
authors: a Leukemia/BMT Program of British Columbia, Division of Hematology , Vancouver General Hospital, University of British Columbia , Vancouver , BC , Canada.
authors: Kevin
authors: K
authors: Song
authors: a Leukemia/BMT Program of British Columbia, Division of Hematology , Vancouver General Hospital, University of British Columbia , Vancouver , BC , Canada.
authors: Heather
authors: H
authors: Sutherland
authors: a Leukemia/BMT Program of British Columbia, Division of Hematology , Vancouver General Hospital, University of British Columbia , Vancouver , BC , Canada.
authors: Cynthia
authors: C
authors: Toze
authors: a Leukemia/BMT Program of British Columbia, Division of Hematology , Vancouver General Hospital, University of British Columbia , Vancouver , BC , Canada.
authors: Yasser
authors: Y
authors: Abou Mourad
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D060830:Consolidation Chemotherapy; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D060046:Maintenance Chemotherapy; D008297:Male; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000175:diagnosis / Q000188:drug therapy* / Q000401:mortality; D012074:Remission Induction; D016896:Treatment Outcome; D055815:Young Adult
keywords: Acute lymphoblastic leukemia; adolescent; adult; asparaginase; chemotherapy