title: Idiopathic CD4 lymphocytopenia with sensorimotor polyneuropathy.
abstract: A, 21-years-old, male, presented with acute onset, gradually progressive, predominantly distal, symmetrical weakness of both upper and lower limbs with arreflexia. He had impaired sensations in glove and stocking distribution with distal gradient. He was found to have absolute CD4 + cell count of 188 cells/μL, absolute CD8 cell count, 532 cells/μL and CD4: CD8 ratio of 0.35. Electrophysiology revealed reduced to absent CMAP amplitude as well as SNAPs in various nerves of upper and lower limbs, along with normal conduction velocity and normal F wave latencies. Pattern evoked visual potentials were prolonged, on both sides, P100 being 130 ms, on right and 108 ms, on left side. In the follow up of 2 years, he showed spontaneous but gradual clinical improvement but his electrophysiological parameters as well as CD 4+ cells count did not show any significant improvement.
authors: Department of Neurology, Govind Ballabh Pant Institute of Post Graduate Medical Education and Research, New Delhi, India.
authors: Vinod
authors: V
authors: Puri
authors: Department of Neurology, Govind Ballabh Pant Institute of Post Graduate Medical Education and Research, New Delhi, India.
authors: Ashish Kumar
authors: AK
authors: Duggal
authors: Department of Neurology, Govind Ballabh Pant Institute of Post Graduate Medical Education and Research, New Delhi, India.
authors: Neera
authors: N
authors: Chaudhry
keywords: Idiopathic CD4 lymphocytopenia; immune mediated neuropathy; neuropathy; optic neuropathy