title: Effects of Anthocyanin on Serum Lipids in Dyslipidemia Patients: A Systematic Review and Meta-Analysis.
abstract: BACKGROUND
  Dyslipidemia was present in most of the patients with coronary heart disease. Epidemiological evidence suggests that anthocyanin has some effects on the serum lipid. However, these results are controversial. This study aimed at collecting current clinical evidence and evaluating the effects of anthocyanin supplementation on total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C) in dialysis patients.
  
  
  METHODS
  The search included PubMed, Web of Science, MEDLINE, Cochrane Library, China National Knowledge Infrastructure, Wanfang Database (up to July 2015) to identify randomized controlled trials (RCTs) on the association between anthocyanin and serum lipids. RevMan (version 5.2) was used for Meta-analysis. Meta-regression analysis, sensitivity analysis and Egger's weighted regression tests were performed by using STATA software (version 12.0; StatCorp, College Station, TX, USA).
  
  
  RESULTS
  Six studies (seven arms) involving 586 subjects were included in this meta-analysis. The results showed that anthocyanin supplementation has significant effects on TC [MD = -24.06, 95% CI(-45.58 to -2.64) mg/dL, I2 = 93%], TG [MD = -26.14, 95%CI(-40.20 to -3.08) mg/dL, I2 = 66%1], LDL-C [MD = -22.10, 95% CI (-34.36 to -9.85) mg/dL, I2 = 61%], and HDL-C(MD = 5.58, 95% CI (1.02 to 10.14) mg/dL;I2 = 90%).
  
  
  CONCLUSIONS
  Anthocyanin supplementation significantly reduces serum TC, TG, and LDL-C levels in patients with dyslipidemia, and increases HDL-C. Further rigorously designed RCTs with larger sample sizes are needed to confirm the effectiveness of anthocyanin supplementation for dyslipidemia, especially hypo high density lipoprotein cholesterolemia.
authors: The First Affiliated Hospital of Zhengzhou University, 450052 Zhengzhou, Henan, China.
authors: Changfeng
authors: C
authors: Liu
authors: Department of Social Medicine and Health Service Management, College of Public Health, Zhengzhou University, 450001 Zhengzhou, PR China.
authors: Jinfeng
authors: J
authors: Sun
authors: The North Hospital of the Ninth People's Hospital of Shanghai City, 201999, Shanghai, China.
authors: Yan
authors: Y
authors: Lu
authors: Department of Nutrition and Food Hygiene, College of Public Health, Zhengzhou University, 450001 Zhengzhou, Henan, China.
authors: Yacong
authors: Y
authors: Bo
mesh_terms: D000872:Anthocyanins / Q000008:administration & dosage*; D019587:Dietary Supplements; D050171:Dyslipidemias / Q000097:blood*; D006801:Humans; D008055:Lipids / Q000097:blood*; D016896:Treatment Outcome
chemical_list: D000872:Anthocyanins; D008055:Lipids