title: Different Genotype of rs3130932 Single Nucleotide Polymorphism Between Gastric Cancer Patients and Normal Subjects.
abstract: OBJECTIVE
  Octamer binding transcription factor B gene (OCT4) is responsible for development and self-renewal maintenance of embryonic stem cells. The rs3130932 single nucleotide polymorphism (SNP) may play a role in tumor genesis. Because of high prevalence of gastric cancer in north of Iran, this study was investigated role of rs3130932 polymorphism and stomach cancer.
  
  
  METHODS
  Blood samples were collected from 100 informed gastric cancer patients and 100 age and sex-matched healthy individuals, and were genotyped for the presence of rs3130932G allele by ssp PCR.
  
  
  RESULTS
  The mean age of participant (n = 200) was 67.83 ± 10.878 years. In genotyping and allelic analysis, TG genotype increased 66.147 times more likely to develop stomach cancer than the TT genotype, and disease risk increases 140.496 times more in GG genotype in comparison with TT genotype.
  
  
  CONCLUSIONS
  This study clearly emphasis on different genetic profile in this population and show that the rs3130932G allele and odds of gastric cancer are related to each other in northern of Iran.
authors: Gastrointestinal Cancer Research Center, Mazandaran University of Medical Science, Sari, Iran.
authors: Zahra
authors: Z
authors: Shahhoseini
authors: Department of Toxicology & Pharmacology, Tehran University of Medical Science, Tehran, Iran.
authors: Fereshteh
authors: F
authors: Jeivad
authors: Gastrointestinal Cancer Research Center, Mazandaran University of Medical Science, Sari, Iran.
authors: Nematollah
authors: N
authors: Ahangar
authors: Immunogenetics Research Center, Mazandaran University of Medical Science, Sari, Iran. abedianks@alumnus.tums.ac.ir.
authors: Saeid
authors: S
authors: Abediankenari
mesh_terms: D000368:Aged; D016022:Case-Control Studies; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D013274:Stomach Neoplasms / Q000235:genetics* / Q000473:pathology
keywords: Gastric cancer; OCT4 gene; Single nucleotide polymorphism