title: Phosphoinositides in Control of Membrane Dynamics.
abstract: Most functions of eukaryotic cells are controlled by cellular membranes, which are not static entities but undergo frequent budding, fission, fusion, and sculpting reactions collectively referred to as membrane dynamics. Consequently, regulation of membrane dynamics is crucial for cellular functions. A key mechanism in such regulation is the reversible recruitment of cytosolic proteins or protein complexes to specific membranes at specific time points. To a large extent this recruitment is orchestrated by phosphorylated derivatives of the membrane lipid phosphatidylinositol, known as phosphoinositides. The seven phosphoinositides found in nature localize to distinct membrane domains and recruit distinct effectors, thereby contributing strongly to the maintenance of membrane identity. Many of the phosphoinositide effectors are proteins that control membrane dynamics, and in this review we discuss the functions of phosphoinositides in membrane dynamics during exocytosis, endocytosis, autophagy, cell division, cell migration, and epithelial cell polarity, with emphasis on protein effectors that are recruited by specific phosphoinositides during these processes.
authors: Centre for Cancer Biomedicine, Faculty of Medicine, University of Oslo, Montebello, N-0379 Oslo, Norway; email: kay.oliver.schink@rr-research.no , stenmark@ulrik.uio.no.|Department of Molecular Cell Biology, Institute for Cancer Research, Oslo University Hospital, Montebello, N-0379 Oslo, Norway.
authors: Kay O
authors: KO
authors: Schink
authors: Centre for Cancer Biomedicine, Faculty of Medicine, University of Oslo, Montebello, N-0379 Oslo, Norway; email: kay.oliver.schink@rr-research.no , stenmark@ulrik.uio.no.|Department of Molecular Cell Biology, Institute for Cancer Research, Oslo University Hospital, Montebello, N-0379 Oslo, Norway.
authors: Kia-Wee
authors: KW
authors: Tan
authors: Centre for Cancer Biomedicine, Faculty of Medicine, University of Oslo, Montebello, N-0379 Oslo, Norway; email: kay.oliver.schink@rr-research.no , stenmark@ulrik.uio.no.|Department of Molecular Cell Biology, Institute for Cancer Research, Oslo University Hospital, Montebello, N-0379 Oslo, Norway.|Centre of Molecular Inflammation Research, Faculty of Medicine, Norwegian University of Science and Technology, N-7491 Trondheim, Norway.
authors: Harald
authors: H
authors: Stenmark
mesh_terms: D000818:Animals; D001343:Autophagy; D002462:Cell Membrane / Q000378:metabolism*; D004705:Endocytosis; D004847:Epithelial Cells / Q000166:cytology / Q000378:metabolism; D005089:Exocytosis; D006801:Humans; D010716:Phosphatidylinositols / Q000378:metabolism*
chemical_list: D010716:Phosphatidylinositols
keywords: autophagy; cell division; cell migration; cytokinesis; endocytosis; exocytosis