title: Intra-tumour IgA1 is common in cancer and is correlated with poor prognosis in bladder cancer.
abstract: A high frequency of IgA1-positive tumour cells was found in tissue micro-arrays of oesophagus, colon, testis, lung, breast, bladder and ovarian cancer. IgA1 was observed in the cytoplasm and the plasma membrane. A correlation was found between intra-tumour IgA1 and poor overall survival in a large cohort of bladder cancer patients (n = 99, p = 0.011, log-rank test). The number of IgA1-positive tumour cells was also found to be higher in female than male bladder cancer patients. The presence of IgA1 was confirmed in formalin-fixed paraffin-embedded ovarian carcinoma samples using LC-MS/MS analysis. Uptake of IgA1 was also observed in breast cancer and melanoma cell lines when cultivated in the presence of serum from healthy individuals, indicating a possible origin of the IgA1 antibodies in cancer cells.
authors: Division of Oncology and Pathology, Dept. of Clinical Sciences Lund, Lund University, Lund, Sweden; Center of Excellence in Biological and Medical Mass Spectrometry (CEBMMS), Biomedical Centre D13, Lund University, Lund, Sweden.
authors: Charlotte
authors: C
authors: Welinder
authors: Division of Oncology and Pathology, Dept. of Clinical Sciences Lund, Lund University, Lund, Sweden.
authors: Karin
authors: K
authors: Jirström
authors: Division of Oncology and Pathology, Dept. of Clinical Sciences Lund, Lund University, Lund, Sweden.
authors: Sophie
authors: S
authors: Lehn
authors: Division of Oncology and Pathology, Dept. of Clinical Sciences Lund, Lund University, Lund, Sweden.
authors: Björn
authors: B
authors: Nodin
authors: Center of Excellence in Biological and Medical Mass Spectrometry (CEBMMS), Biomedical Centre D13, Lund University, Lund, Sweden.
authors: György
authors: G
authors: Marko-Varga
authors: Chemical Glyco-Biology Laboratory, Dept. of Chemistry, Copenhagen University, Copenhagen, Denmark.
authors: Ola
authors: O
authors: Blixt
authors: Clinical Chemistry and Pharmacology, Dept. of Laboratory Medicine, Lund University, Lund, Sweden.
authors: Lena
authors: L
authors: Danielsson
authors: Division of Oncology and Pathology, Dept. of Clinical Sciences Lund, Lund University, Lund, Sweden.
authors: Bo
authors: B
authors: Jansson
keywords: Medicine