title: [Pathophysiology of hemorragic shock].
abstract: This review addresses the pathophysiology of hemorrhagic shock, a condition produced by rapid and significant loss of intravascular volume, which may lead to hemodynamic instability, decreases in oxygen delivery, decreased tissue perfusion, cellular hypoxia, organ damage, and death. The initial neuroendocrine response is mainly a sympathetic activation. Haemorrhagic shock is associated altered microcirculatory permeability and visceral injury. It is also responsible for a complex inflammatory response associated with hemostasis alteration.
authors: Service d'anesthésie-réanimation chirurgicale, hôpitaux universitaires de Strasbourg, nouvel hôpital civil, 1, place de l'Hôpital, BP 426, 67091 Strasbourg cedex, France.
authors: R
authors: R
authors: Copotoiu
authors: Service d'anesthésie-réanimation chirurgicale, hôpitaux universitaires de Strasbourg, nouvel hôpital civil, 1, place de l'Hôpital, BP 426, 67091 Strasbourg cedex, France.
authors: E
authors: E
authors: Cinca
authors: Service d'anesthésie-réanimation chirurgicale, hôpitaux universitaires de Strasbourg, nouvel hôpital civil, 1, place de l'Hôpital, BP 426, 67091 Strasbourg cedex, France.
authors: O
authors: O
authors: Collange
authors: Service d'anesthésie-réanimation chirurgicale, hôpitaux universitaires de Strasbourg, nouvel hôpital civil, 1, place de l'Hôpital, BP 426, 67091 Strasbourg cedex, France.
authors: F
authors: F
authors: Levy
authors: Service d'anesthésie-réanimation chirurgicale, hôpitaux universitaires de Strasbourg, nouvel hôpital civil, 1, place de l'Hôpital, BP 426, 67091 Strasbourg cedex, France. Electronic address: paul-michel.mertes@chru-strasbourg.fr.
authors: P-M
authors: PM
authors: Mertes
mesh_terms: D000222:Adaptation, Physiological; D000818:Animals; D001810:Blood Volume; D002628:Chemoreceptor Cells / Q000502:physiology; D004211:Disseminated Intravascular Coagulation / Q000209:etiology / Q000503:physiopathology; D006439:Hemodynamics; D006801:Humans; D007022:Hypotension / Q000209:etiology / Q000503:physiopathology; D000860:Hypoxia / Q000209:etiology; D007249:Inflammation / Q000209:etiology / Q000503:physiopathology; D008833:Microcirculation; D023421:Models, Animal; D010100:Oxygen / Q000097:blood; D011311:Pressoreceptors / Q000502:physiology; D012771:Shock, Hemorrhagic / Q000503:physiopathology*; D013564:Sympathetic Nervous System / Q000503:physiopathology; D014661:Vasoconstriction / Q000502:physiology
chemical_list: D010100:Oxygen
keywords: Choc hémorragique; Coagulopathie; Coagulopathy; Hemorrhagic shock; Inflammation; Oxygen delivery; Transport d’oxygène