title: The intervention research on treatment by Xianchen to rabbits model of chemotherapeutic phlebitis.
abstract: OBJECTIVE
  To develop a chemotherapeutics induced phlebitis and explore the effects of Xianchen on the phlebitis treatment.
  
  
  METHODS
  Forty-eight rabbits were divided into two series. Phlebitis model induced by vincristine was established at each series. The first series had 24 rabbits, which were divided into four groups (6 hours, 12 hours, 18 hours, 24 hours) after vincristine infusion. The grades of phlebitis through visual observation and histopathological examination were observed. The second series had also 24 rabbits. Interventions were performed 12 hours after vincristine infusion. These rabbits were randomly divided into four groups, according to treatment: Hirudoid (bid), Xianchen (daily), Xianchen (tid), Xianchen (five times a day). Four days after intervention, the venous injury through visual observation and histopathological examination were evaluated.
  
  
  RESULTS
  Series 1: Phlebitis appeared 12 hours after infusion of vincristine through visual observation. There was a significant difference (p<0.05) between 6 hours and 24 hours, 6 hours and 18 hours through visual observation. However, the inflammation happened 6 hours after infusion, the loss of venous endothelial cells demonstrated differences among four groups through histopathological evaluation (p<0.05). There were significant differences (p<0.05) after 4 days among the intervention groups through visual observation, the effects of Xianchen group (five times a day) were better than Xianchen group (tid) (p<0.01). The treatment of edema demonstrated differences among groups through histopathological evaluation (p<0.05), Xianchen (five times a day) better relieved the degree of edema (p<0.05).
  
  
  CONCLUSIONS
  The study showed that inflammatory reaction of phlebitis appeared early. Xianchen can treat vincristine induced phlebitis, as well as Hirudoid. It is particularly effective in the treatment of edema, and there is a remarkable dose-response relationship.
authors: Full Professor, Department of Nursing, Bengbu Medical College, China. Conception and design of the study, critical revision.
authors: Jing
authors: J
authors: Zhang
authors: Graduate student, Department of Nursing, Bengbu Medical College, China. Technical procedures, manuscript preparation.
authors: Juan
authors: J
authors: Shen
authors: Graduate student, Department of Nursing, Bengbu Medical College, China. Technical procedures, manuscript preparation.
authors: Weiwei
authors: W
authors: Yin
authors: Graduate student, Department of Nursing, Bengbu Medical College, China. Technical procedures.
authors: Xiaoyu
authors: X
authors: Wei
authors: Assistant Professor, Department of Pathology, First Hospital Affiliated to Bengbu Medical College, China. Histopathological examinations.
authors: Ligao
authors: L
authors: Wu
authors: Full Professor, Department of Pharmacology, Bengbu Medical College, China. Conception and design of the study.
authors: Hao
authors: H
authors: Liu
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage*; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage*; D004487:Edema / Q000188:drug therapy*; D007262:Infusions, Intravenous; D008516:Medicine, Chinese Traditional / Q000379:methods; D010689:Phlebitis / Q000139:chemically induced / Q000188:drug therapy* / Q000517:prevention & control; D008517:Phytotherapy / Q000379:methods*; D010936:Plant Extracts / Q000008:administration & dosage*; D011817:Rabbits; D014750:Vincristine
chemical_list: D000893:Anti-Inflammatory Agents; D004365:Drugs, Chinese Herbal; D010936:Plant Extracts; D014750:Vincristine