title: The compliance of thromboprophylaxis affects the risk of venous thromboembolism in patients undergoing hip fracture surgery.
abstract: OBJECTIVE
  Venous thromboembolism (VTE) is major problem after hip fracture surgery with substantial morbidity and mortality. This study aimed to assess the postoperative compliance of thromboprophylaxis in elderly patients undergoing hip fracture surgery and to confirm the correlation between compliance and VTE risk.
  
  
  METHODS
  This retrospective cohort study included consecutive elderly hip fracture patients who undergoing surgery. According to the thromboprophylaxis regimens, patients were divided into non-compliant group (<14days), poor compliant group (14-27days) and good compliant group (≥28days). The primary outcome was the incidence of symptomatic DVT, PE within 6weeks postoperatively.
  
  
  RESULTS
  Between 2008 and 2012, 1214 eligible patients were included in this study. 761 (64.7%) patients were non-compliant, 224 (19.0%) patients were poor compliant, and 192 (16.3%) patients were good compliant. The overall VTE rate was 7.9% (73/1177), PE rate was 0.3% (4/1177). The VTE rate in good compliant group was lowest among three groups (4.2 vs. 5.4 vs. 9.6%, P=0.013), but the PE rates showed no significant differences (0 vs. 0.9 vs. 0.3%, P=0.241). The multivariate analysis showed that non-compliance was an independent risk factor of suffering VTE undergoing hip fracture surgery.
  
  
  CONCLUSIONS
  In this study we found fewer than 1 in 5 patients maintained compliant with thromboprophylaxis guidelines after discharge following hip surgery. This is particularly concerning because those who were non-compliant had a higher risk of VTE postoperatively compared with those who were good compliant.
authors: Department of Orthopaedics, Chinese PLA General Hospital, 28 Fuxing Road, Haidian District, Beijing, 100853 People's Republic of China.
authors: Yuan
authors: Y
authors: Gao
authors: Department of Orthopaedics, Beijing Luhe Hospital, Capital Medical University, Beijing, 101149 People's Republic of China.|School of Medicine, Nankai University, Tianjing, 300071 People's Republic of China.
authors: Anhua
authors: A
authors: Long
authors: School of Medicine, Nankai University, Tianjing, 300071 People's Republic of China.
authors: Zongyan
authors: Z
authors: Xie
authors: Department of Orthopaedics, Chinese PLA General Hospital, 28 Fuxing Road, Haidian District, Beijing, 100853 People's Republic of China.|School of Medicine, Nankai University, Tianjing, 300071 People's Republic of China.
authors: Yutong
authors: Y
authors: Meng
authors: Department of Orthopaedics, Chinese PLA General Hospital, 28 Fuxing Road, Haidian District, Beijing, 100853 People's Republic of China.
authors: Jing
authors: J
authors: Tan
authors: Department of Orthopaedics, Chinese PLA General Hospital, 28 Fuxing Road, Haidian District, Beijing, 100853 People's Republic of China.
authors: Houchen
authors: H
authors: Lv
authors: Department of Orthopaedics, Chinese PLA General Hospital, 28 Fuxing Road, Haidian District, Beijing, 100853 People's Republic of China.
authors: Licheng
authors: L
authors: Zhang
authors: Department of Orthopaedics, Chinese PLA General Hospital, 28 Fuxing Road, Haidian District, Beijing, 100853 People's Republic of China.
authors: Lihai
authors: L
authors: Zhang
authors: Department of Orthopaedics, Chinese PLA General Hospital, 28 Fuxing Road, Haidian District, Beijing, 100853 People's Republic of China.
authors: Peifu
authors: P
authors: Tang
keywords: Compliance; Guideline adherence; Hip fracture; Rivaroxaban; Venous thromboembolism