title: A longitudinal study of the effect of heparin thromboprophylaxis during pregnancy on maternal bone metabolism.
abstract: The aim of this study was to determine the effect of heparin thromboprophylaxis during pregnancy on maternal biochemical markers of bone metabolism. This was a prospective longitudinal study of carboxy terminal pro-peptide of type I collagen (PICP) and cross-linked carboxyterminal telopeptide of type I collagen (ICTP) levels in 15 women, who had heparin thromboprophylaxis during pregnancy compared with those of 18 normal pregnant controls. During pregnancy, the rate of change of PICP and ICTP in women who had heparin thromboprophylaxis was similar to those of women who did not (P = 0.184 for PICP, and P = 0.129 for ICTP), and PICP and ICTP levels at individual time points were similar in both groups. Therefore, heparin thromboprophylaxis during pregnancy does not affect maternal biochemical markers of bone metabolism.
authors: Department of Obstetrics and Gynecology, McGill University, Royal Victoria Hospital , 687 Pine Avenue West, Montreal , Canada H3A 1A1.
authors: O
authors: O
authors: Ogueh
authors: Academic Obstetrics and Gynaecology, Imperial College School of Medicine, Chelsea and Westminster Hospital , 369 Fulham Road, London SW10 9NH , UK.
authors: M R
authors: MR
authors: Johnson
authors: Department of Obstetrics and Gynecology, McGill University, Royal Victoria Hospital , 687 Pine Avenue West, Montreal , Canada H3A 1A1.
authors: A
authors: A
authors: Benjamin
keywords: ICTP; PICP; heparin; pregnancy