title: The viability of transplanting organs from donors who underwent cardiopulmonary resuscitation: A systematic review.
abstract: To identify reports of patients who underwent cardiopulmonary resuscitation (CPR) prior to solid organ donation and compare recipient and organ function outcomes to those that did not undergo CPR. Donation after restoration of circulation then progressing to death and those donating with on-going CPR who would have otherwise have termination of efforts were both included.
  
  
  
  Systematic review. Clinical studies comparing the outcome of patients and organs retrieved from donors who underwent CPR with those that did not require CPR. Full-text articles were searched on EmBASE, MEDLINE, Cochrane Database of Systematic Reviews and the Cochrane Register of Controlled Trials.
  
  
  
  Twenty-two observational studies were included. There were 12,206 adult and 2552 paediatric organ transplantation identified. Comparing donation after restoration of circulation there was no difference in immediate, one year, and five-year graft function. Donation with on-going CPR was associated with reduced immediate graft function for both renal and hepatic transplantation, however long term function was not different.
  
  
  
  CPR does not appear to adversely affect graft function. Patients who have restored circulation after resuscitation and subsequently progress to death should be evaluated for organ donation. Those with on-going CPR should be considered for hepatic and renal transplantation but there may be worse initial graft function.
authors: Department of Anaesthesia Intensive Care, Southmead Hospital, Bristol BS10 5NB, UK. Electronic address: stephenwest@doctors.org.uk.
authors: Stephen
authors: S
authors: West
authors: Department of Anaesthesia Intensive Care, Southmead Hospital, Bristol BS10 5NB, UK.
authors: Jasmeet
authors: J
authors: Soar
authors: Department of Emergency Medicine and Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA 15260, USA.
authors: Clifton W
authors: CW
authors: Callaway
mesh_terms: D000328:Adult; D016887:Cardiopulmonary Resuscitation / Q000401:mortality*; D016022:Case-Control Studies; D002648:Child; D051799:Delayed Graft Function / Q000209:etiology*; D006323:Heart Arrest / Q000401:mortality; D006801:Humans; D064887:Observational Studies as Topic; D016377:Organ Transplantation / Q000706:statistics & numerical data*; D014019:Tissue Donors / Q000706:statistics & numerical data; D009927:Tissue and Organ Procurement / Q000706:statistics & numerical data*
keywords: Cardiac arrest; Cardiopulmonary resuscitation; Organ donation; Transplantation