title: Multiple Meningiomas in a Patient with Cowden Syndrome.
abstract: BACKGROUND
  Cowden syndrome is a rare, multisystem disease manifesting with increased hamartomas and neoplasms. Though meningioma has been documented in patients with Cowden syndrome, the relationship between these two phenomena is still unclear.
  
  
  METHODS
  We report a case of a 43-year-old female patient with a known PTEN mutation and clinical history of Cowden syndrome. A workup of headache demonstrated two skull base meningiomas. At the time of surgery, several additional tiny meningiomas were detected in the same region.
  
  
  CONCLUSIONS
  The development of multiple meningiomas in a patient with predisposition for tumor is more than coincidental. Though PTEN mutations and deletions have not been shown to be critical for meningioma development, this case challenges that conclusion. In light of recent genetic advances in meningioma molecular pathogenesis, the role of the PTEN/AKT/PI3K pathway is discussed.
authors: Department of Neurosurgery, The Mount Sinai Hospital, New York, New York, United States.
authors: Margaret
authors: M
authors: Pain
authors: Department of Pathology, The Mount Sinai Hospital, New York, New York, United States.
authors: Armine
authors: A
authors: Darbinyan
authors: Department of Pathology, The Mount Sinai Hospital, New York, New York, United States.
authors: Mary
authors: M
authors: Fowkes
authors: Department of Neurosurgery, The Mount Sinai Hospital, New York, New York, United States.
authors: Raj
authors: R
authors: Shrivastava
keywords: Cowden syndrome; PTEN; meningioma