title: Long non-coding RNA MALAT1 acts as a competing endogenous RNA to promote malignant melanoma growth and metastasis by sponging miR-22.
abstract: Long non-coding RNAs (lncRNAs) are involved in tumorigenesis. Metastasis-associated lung adenocarcinoma transcript 1 (MALAT1), an lncRNAs, is associated with the growth and metastasis of many human tumors, but its biological roles in malignant melanoma remain unclear. In this study, the aberrant up-regulation of MALAT1 was detected in melanoma. We determined that MALAT1 promotes melanoma cells proliferation, invasion and migration by sponging miR-22. MiR-22 was decreased and acted as a tumor suppressor in melanoma, and MMP14 and Snail were the functional targets of miR-22. Furthermore, MALAT1 could modulate MMP14 and Snail by operating as a competing endogenous RNA (ceRNA) for miR-22. The effects of MALAT1 in malignant melanoma is verified using a xenograft model. This finding elucidates a new mechanism for MALAT1 in melanoma development and provides a potential target for melanoma therapeutic intervention.
authors: Department of Plastic Surgery, Affiliated People's Hospital of Jiangsu University, Zhenjiang, Jiangsu, China.
authors: Wenkang
authors: W
authors: Luan
authors: Department of Neurosurgery, Affiliated People's Hospital of Jiangsu University, Zhenjiang, Jiangsu, China.
authors: Lubo
authors: L
authors: Li
authors: Department of Neurosurgery, Nanjing First Hospital, Nanjing Medical University, Nanjing, China.
authors: Yan
authors: Y
authors: Shi
authors: Department of General Surgery, Affiliated People's Hospital of Jiangsu University, Zhenjiang, Jiangsu, China.
authors: Xuefeng
authors: X
authors: Bu
authors: Department of Plastic Surgery, Affiliated People's Hospital of Jiangsu University, Zhenjiang, Jiangsu, China.
authors: Yun
authors: Y
authors: Xia
authors: Department of Plastic Surgery, Affiliated People's Hospital of Jiangsu University, Zhenjiang, Jiangsu, China.
authors: Jinlong
authors: J
authors: Wang
authors: Department of Plastic Surgery, Affiliated People's Hospital of Jiangsu University, Zhenjiang, Jiangsu, China.
authors: Henry Siaw
authors: HS
authors: Djangmah
authors: Department of Plastic Surgery, Affiliated People's Hospital of Jiangsu University, Zhenjiang, Jiangsu, China.
authors: Xiaohui
authors: X
authors: Liu
authors: Department of Neurosurgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
authors: Yongping
authors: Y
authors: You
authors: Department of Plastic Surgery, Affiliated People's Hospital of Jiangsu University, Zhenjiang, Jiangsu, China.
authors: Bin
authors: B
authors: Xu
mesh_terms: D000230:Adenocarcinoma; D000077192:Adenocarcinoma of Lung; D000818:Animals; D017209:Apoptosis; D045744:Cell Line, Tumor; D002465:Cell Movement; D049109:Cell Proliferation; D002471:Cell Transformation, Neoplastic / Q000235:genetics; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008175:Lung Neoplasms; D053511:Matrix Metalloproteinase 14 / Q000235:genetics; D008545:Melanoma / Q000235:genetics* / Q000378:metabolism; D051379:Mice; D008819:Mice, Nude; D035683:MicroRNAs / Q000235:genetics*; D009361:Neoplasm Invasiveness; D009362:Neoplasm Metastasis; D009368:Neoplasm Transplantation; D062085:RNA, Long Noncoding / Q000235:genetics*; D012878:Skin Neoplasms / Q000235:genetics* / Q000378:metabolism; D000096142:Cutaneous Malignant Melanoma
chemical_list: C557041:MALAT1 long non-coding RNA, human; C548375:MIRN22 microRNA, human; D035683:MicroRNAs; D062085:RNA, Long Noncoding; C507086:MMP14 protein, human; D053511:Matrix Metalloproteinase 14
keywords: MALAT1; MMP14 and Snail; ceRNA; melanoma; miR-22