title: Concentrated Phosphatidic Acid in Cereal Brans as Potential Protective Agents against Indomethacin-Induced Stomach Ulcer.
abstract: One of complications associated with long-term use of nonsteroidal anti-inflammatory drugs (NSAIDs) is peptic ulcer. Recently, we found that orally administered phosphatidic acid (PA) ameliorated aspirin-induced stomach lesions in mice. In this study, we identified PA-rich food sources and examined the effects of the food materials on indomethacin-induced stomach ulcer. Among examined, buckwheat (Fagopyrum esculentum) bran contained the highest level of PA (188 mg/100 g). PA was the richest phospholipid (25%) in the lipid fraction of the buckwheat bran. Administration of the lipid extracts of buckwheat bran significantly ameliorated indomethacin-induced stomach lesions in mice. In contrast, wheat (Triticum durum) bran lipids (PA, 4%) and soybean (Glycine max) lipids (PA, 3%) were not associated with ameliorative effects. These results indicated that PA-rich lipids can be used as an effective supplement for prevention of NSAID-induced stomach ulcer.
authors: Institute of Biomedical Sciences, Tokushima University Graduate School , Tokushima 770-8505, Japan.
authors: Sheuli
authors: S
authors: Afroz
authors: Institute of Biomedical Sciences, Tokushima University Graduate School , Tokushima 770-8505, Japan.
authors: Teru
authors: T
authors: Ikoma
authors: Institute of Biomedical Sciences, Tokushima University Graduate School , Tokushima 770-8505, Japan.
authors: Ayano
authors: A
authors: Yagi
authors: Institute of Biomedical Sciences, Tokushima University Graduate School , Tokushima 770-8505, Japan.
authors: Kentaro
authors: K
authors: Kogure
authors: Department of Pharmaceutical Life Sciences, Faculty of Pharmacy, Yasuda Women's University , Hiroshima 731-0351, Japan.
authors: Akira
authors: A
authors: Tokumura
authors: Institute of Biomedical Sciences, Tokushima University Graduate School , Tokushima 770-8505, Japan.
authors: Tamotsu
authors: T
authors: Tanaka
mesh_terms: D000818:Animals; D002523:Edible Grain / Q000737:chemistry*; D019612:Fagopyrum / Q000737:chemistry; D005753:Gastric Mucosa / Q000187:drug effects; D006801:Humans; D007213:Indomethacin / Q000009:adverse effects; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D010712:Phosphatidic Acids / Q000008:administration & dosage*; D010936:Plant Extracts / Q000008:administration & dosage*; D020011:Protective Agents / Q000008:administration & dosage*; D012639:Seeds / Q000737:chemistry; D013025:Glycine max / Q000737:chemistry; D013276:Stomach Ulcer / Q000139:chemically induced / Q000517:prevention & control*; D014908:Triticum / Q000737:chemistry
chemical_list: D010712:Phosphatidic Acids; D010936:Plant Extracts; D020011:Protective Agents; D007213:Indomethacin
keywords: cereal brans; lysophosphatidic acid; phosphatidic acid; phospholipase A2; stomach ulcer