title: Recent advances on the use of cyclodextrins in the chiral analysis of drugs by capillary electrophoresis.
abstract: The most recent advances on the use of cyclodextrins as chiral selectors in capillary electrophoresis for the enantioseparation of drugs are reviewed in this article. The types of cyclodextrins employed and the resolutions achieved are discussed. The use of dual chiral systems, modified capillaries, non-aqueous media or microfluidic devices is also included and the mechanisms for enantioseparation of drugs and the inversion of the enantiomer migration order are studied. The most relevant applications developed to carry out the quantitation of chiral drugs, to assess the enantiomeric purity of pharmaceutical formulations, to study their metabolism or to achieve criminalistic or forensic investigations are described. Articles published in the last six years (period from 2010 to 2015) are considered.
authors: Departamento de Química Analítica, Química Física e Ingeniería Química, Facultad de Biología, Ciencias Ambientales y Química, Universidad de Alcalá, Ctra. Madrid-Barcelona, Km. 33.600, 28871 Alcalá de Henares, Madrid, Spain.
authors: J M
authors: JM
authors: Saz
authors: Departamento de Química Analítica, Química Física e Ingeniería Química, Facultad de Biología, Ciencias Ambientales y Química, Universidad de Alcalá, Ctra. Madrid-Barcelona, Km. 33.600, 28871 Alcalá de Henares, Madrid, Spain. Electronic address: mluisa.marina@uah.es.
authors: M L
authors: ML
authors: Marina
mesh_terms: D002623:Chemistry Techniques, Analytical / Q000639:trends*; D003505:Cyclodextrins / Q000737:chemistry*; D019075:Electrophoresis, Capillary; D004364:Pharmaceutical Preparations / Q000032:analysis / Q000302:isolation & purification*; D013237:Stereoisomerism
chemical_list: D003505:Cyclodextrins; D004364:Pharmaceutical Preparations
keywords: Analysis; Capillary electrophoresis; Chiral; Cyclodextrins; Drugs; Enantiomer