title: The biomarkers of immune dysregulation and inflammation response in Parkinson disease.
abstract: Parkinson's disease (PD) is referring to the multi-systemic α-synucleinopathy with Lewy bodies deposited in midbrain. In ageing, the environmental and genetic factors work together and overactive major histocompatibility complex pathway to regulate immune reactions in central nerve system which resulting in neural degeneration, especially in dopaminergic neurons. As a series of biomarkers, the human leukocyte antigen genes with its related proteomics play cortical roles on the antigen presentation of major histocompatibility complex molecules to stimulate the differentiation of T lymphocytes and i-proteasome activities under their immune response to the PD-related environmental alteration and genetic variation. Furthermore, dopaminergic drugs change the biological characteristic of T lymphatic cells, affect the α-synuclein presentation pathway, and inhibit T lymphatic cells to release cytotoxicity in PD development. Taking together, the serum inflammatory factors and blood T cells are involved in the immune dysregulation of PD and inspected as the potential clinic biomarkers for PD prediction.
authors: Department of Neurology, The First Affiliated Hospital of Guangzhou Medical University, Guangdong, 510120 China.
authors: Li
authors: L
authors: Chen
authors: Department of Neurology, The First Affiliated Hospital of Guangzhou Medical University, Guangdong, 510120 China.
authors: Mingshu
authors: M
authors: Mo
authors: Department of Neurology, The Affiliated Huadu Hospital of Southern Medical University, Guangzhou, 510800 China.
authors: Guangning
authors: G
authors: Li
authors: Department of Neurology, The First Affiliated Hospital of Sun Yat-sen University, Guangdong, 510080 China.
authors: Luan
authors: L
authors: Cen
authors: Department of Neurology, The First Affiliated Hospital of Guangzhou Medical University, Guangdong, 510120 China ; Department of Neurology, The Third Affiliated Hospital of Sun Yat-sen University, Guangdong, 510082 China.
authors: Lei
authors: L
authors: Wei
authors: Department of Neurology, The First Affiliated Hospital of Sun Yat-sen University, Guangdong, 510080 China.
authors: Yousheng
authors: Y
authors: Xiao
authors: Department of Neurology, The First Affiliated Hospital of Guangzhou Medical University, Guangdong, 510120 China.
authors: Xiang
authors: X
authors: Chen
authors: Ann Romney Center for Neurologic Disease, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115 USA.
authors: Shaomin
authors: S
authors: Li
authors: Department of Neurology, The Third Affiliated Hospital of Xinjiang Medical University, Urumqi, 830011 China.
authors: Xinling
authors: X
authors: Yang
authors: Department of Blood Transfusion, The Fifth Affiliated Hospital, Southern Medical University, Guangzhou, Guangdong 510900 China.
authors: Shaogang
authors: S
authors: Qu
authors: Department of Neurology, The First Affiliated Hospital of Guangzhou Medical University, Guangdong, 510120 China ; Department of Neurology, The First Affiliated Hospital of Sun Yat-sen University, Guangdong, 510080 China.
authors: Pingyi
authors: P
authors: Xu
keywords: Biomarkers; Inflammation; Parkinson’s disease; α-synucleinopathy