title: Metastatic Gliosarcoma: Cytopathologic Characteristics with Histopathologic Correlations.
abstract: Gliosarcoma is a rare variant of glioblastoma multiforme characterized by a biphasic pattern of glial and mesenchymal differentiation. Fine-needle aspiration (FNA) is routinely employed to diagnose a number of primary and secondary malignancies in a variety of clinical settings. Herein, we describe the cytomorphologic features of a gliosarcoma metastatic to an extracranial location accompanied by corresponding clinico-radiologic and histopathologic findings in a 51-year-old man with a posterior mediastinal mass. The cytologic smears displayed a pleomorphic tumor comprised of spindled and epithelioid malignant cells. This case illustrates the ability of FNA to adequately diagnose a rare malignancy in the appropriate clinico-radiologic setting.
authors: Department of Pathology, The Johns Hopkins Hospital, Baltimore, Md., USA.
authors: James
authors: J
authors: Lee
authors: Fausto
authors: F
authors: Rodriguez
authors: Syed Z
authors: SZ
authors: Ali
mesh_terms: D044963:Biopsy, Fine-Needle / Q000379:methods; D001932:Brain Neoplasms / Q000175:diagnosis* / Q000473:pathology*; D003581:Cytodiagnosis / Q000379:methods; D003937:Diagnosis, Differential; D015622:Epithelioid Cells / Q000473:pathology; D005909:Glioblastoma / Q000175:diagnosis / Q000473:pathology; D018316:Gliosarcoma / Q000175:diagnosis* / Q000473:pathology*; D006801:Humans; D008297:Male; D008875:Middle Aged