title: Dual functionalized poly(vinylidene fluoride) membrane with acryloylmorpholine and argatroban to improve antifouling and hemocompatibility.
abstract: The present work aims to improve the antifouling properties and anticoagulation of poly(vinylidene fluoride) (PVDF) membrane by dual modification. An amphiphilic copolymer of PVDF-g-(polyacryloylmorpholine-(polyacrylic acid)) [PVDF-g-(PACMO-PAA)] was first prepared by the free radical copolymerization. Then argatroban, a commonly used anticoagulant, was successfully grafted to PVDF-g-(PACMO-PAA). Finally the obtained copolymer was casted into a flat membrane via immersion phase inversion. The as-prepared copolymer membranes show improved hydrophilicity, higher water flux and lower protein adsorption. Moreover, the hemolysis and coagulation tests for the dual functionalized PVDF membrane exhibit decreased hemolysis ratio, with prolonged plasma recalcification time, activated partial thromboplastin time and thrombin time. PVDF membrane incorporating PACMO and AG reveals an improved hemocompatibility, which has a good potential to be used in blood purification. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 105A: 178-188, 2017.
authors: State Key Laboratory of Separation Membranes and Membrane Processes, School of Material Science and Engineering, Tianjin Polytechnic University, Tianjin, 300387, China.
authors: Rui
authors: R
authors: Xu
authors: State Key Laboratory of Separation Membranes and Membrane Processes, School of Material Science and Engineering, Tianjin Polytechnic University, Tianjin, 300387, China.
authors: Qianqian
authors: Q
authors: Feng
authors: State Key Laboratory of Separation Membranes and Membrane Processes, School of Material Science and Engineering, Tianjin Polytechnic University, Tianjin, 300387, China.
authors: Yang
authors: Y
authors: He
authors: State Key Laboratory of Separation Membranes and Membrane Processes, School of Environmental and Chemical Engineering, Tianjin Polytechnic University, Tianjin, 300387, China.
authors: Fanyong
authors: F
authors: Yan
authors: State Key Laboratory of Separation Membranes and Membrane Processes, School of Material Science and Engineering, Tianjin Polytechnic University, Tianjin, 300387, China.|School of Material Science and Engineering, Tianjin University of Technology, Tianjin, 300384, China.
authors: Li
authors: L
authors: Chen
authors: State Key Laboratory of Separation Membranes and Membrane Processes, School of Material Science and Engineering, Tianjin Polytechnic University, Tianjin, 300387, China.
authors: Yiping
authors: Y
authors: Zhao
mesh_terms: D001120:Arginine / Q000031:analogs & derivatives; D005260:Female; D006801:Humans; D008297:Male; D008422:Materials Testing; D008567:Membranes, Artificial; D009025:Morpholines / Q000737:chemistry*; D010314:Partial Thromboplastin Time; D010875:Pipecolic Acids / Q000737:chemistry*; D011145:Polyvinyls / Q000737:chemistry*; D013449:Sulfonamides; D013918:Thrombin Time; D005465:Fluorocarbon Polymers
chemical_list: D001120:Arginine; D008567:Membranes, Artificial; D009025:Morpholines; D010875:Pipecolic Acids; D011145:Polyvinyls; D013449:Sulfonamides; C024865:polyvinylidene fluoride; D005465:Fluorocarbon Polymers; C031942:argatroban
keywords: acryloylmorpholine; antifouling; argatroban; hemocompatibility; poly(vinylidene fluoride)