title: Comparative clinicoradiographical evaluation of effect of aminobisphosphonate (sodium alendronate) on peri-implant bone status: Controlled clinical trial.
abstract: OBJECTIVE
  The present study aims to compare the peri-implant bone status around immediately loaded dental implants treated with aminobisphosphonate solution and untreated control implants in terms of clinical and radiographical parameters.
  
  
  METHODS
  A total of 24 patients were randomly divided equally into two groups. This study was conducted in accordance to the Helsinki's declaration of 1975, revised in 2000, and with the approval of the institutional ethical committee. In the control group after preparation, osteotomy sites were irrigated with normal saline solution, whereas in the test group osteotomy sites were irrigated with modified bisphosphonate solution and then TRX-OP, Hi-Tec dental implants were inserted. Clinical parameters, such as modified plaque and gingival index, probing depth, mobility, and radiographic parameters were recorded at baseline (0), 3, 6, and 9 months. Data analysis was performed using the Statistical Package for the Social Sciences version 17 for windows, and the statistical techniques employed were repeated measures analysis of variance, independent sample t-test, and paired sample t-test.
  
  
  RESULTS
  Reduction in mean radiographic bone levels (height) was observed on the mesial and distal aspect of the control group in comparison to its baseline at all intervals. In the test group, there was reduction in mean radiographic bone levels on mesial and distal aspect of the implant site in comparison to its baseline till 6-month follow up, however, at 9 month, there was gain in bone level on both mesial and distal aspect of implant. This represents the effectiveness of sodium alendronate in enhancing the bone formation. On comparison, between both groups on mesial and distal aspect of implants, statistically significant differences were observed at 3 and 9 months on mesial and distal aspect, respectively, without any clinical evidence of mobility in the test group.
  
  
  CONCLUSIONS
  Implant site treated with aminobisphosphonate solution represents greater efficacy in enhancing bone formation when used as an irrigant; thus, it is considered beneficial in implant dentistry.
authors: Depatrment of Periodontology, Maharaja Ganga Singh Dental College and Research Centre, Sri Ganganagar, Rajasthan, India.
authors: Rajni
authors: R
authors: Aggarwal
authors: Department of Pedodontics, Sharavthi Dental College, Shimoga, Karnataka, India.
authors: Prashant
authors: P
authors: Babaji
authors: Department of Peridontology, Sri Venkateshwara Dental College, Pondichery, India.
authors: S Senthil
authors: SS
authors: Nathan
authors: Department of Prosthodontics, PSM College of Dental Science and Research, Thrissur, Kerala, India.
authors: George
authors: G
authors: Attokaran
authors: Department of Oral and Maxillofacial Surgery, AME's Dental College and Hospital, Raichur, Karnataka, India.
authors: S M
authors: SM
authors: Santosh Kumar
authors: Department of Conservative Dentistry and Endodontuics, HKDET's Dental College and Hospital, Humnabad, Karnataka, India.
authors: Sharanpriya
authors: S
authors: Sathnoorkar
keywords: Aminobisphosphonate; bisphosphonates; bone resorption; immediately loaded implants; sodium alendronate