title: [131I and99mTc-Uptake in focal thyroid autonomies. Development in Germany since the 1980s].
abstract: Germany has developed into a country with a nationwide largely sufficient iodine supply due to improved alimentary iodine supply. The reduction of iodine uptake in focal autonomies induced by reduced iodine avidity was evaluated by Gotthardt et al. 2006, showing a significant decline of pertechnetate uptake up to the year 2004.
  
  
  OBJECTIVE
  This study was intended to carry this investigation forward to the present day to analyze the course of a conjectural stabilization of iodine uptake values.
  
  
  METHODS
  283 patients who underwent radioiodine therapy for focal thyroid were analyzed retrospectively. Pertechnetate uptake was measured scintigraphically, thyroid volume sonographically and iodine uptake by iodine uptake test. The uptake percentage in the autonomous volume was correlated with autonomous volume and the resulting values tracked over a time period of seven years.
  
  
  RESULTS
  Mean thyroid volume ranged from 24 to 29 ml, autonomous volume from 7.2 to 9.4 ml. Pertechnetate uptake ranged from 0.2 to 0.25%/ml autonomous volume. Iodine uptake values ranged from 3.2 to 4.2%/ml autonomous volume. None of the changes observed were statistically significant (all p>0.05).
  
  
  CONCLUSIONS
  Prophylactic measures towards improvement of the general public´s iodine supply in Germany had led to a decline of pertechnetate and iodine uptake in the thyroid up until the turn of the millennium. The here presented data show a stabilization of99mTc-Uptake. Our study could also show that actual iodine uptake has stabilized at a steady level over the preceding seven years.
authors: Christian Happel, Universitätsklinikum Frankfurt am Main, Klinik für Nuklearmedizin, Theodor Stern Kai 7, 60590 Frankfurt am Main, Tel. 069/63 01 43 30, Fax 069/63 01 38 58, E-Mail: Christian.Happel@kgu.de.
authors: Christian
authors: C
authors: Happel
authors: W Tilman
authors: WT
authors: Kranert
authors: Benjamin
authors: B
authors: Bockisch
authors: Hüdayi
authors: H
authors: Korkusuz
authors: Frank
authors: F
authors: Grünwald
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D007457:Iodine Radioisotopes / Q000493:pharmacokinetics*; D008297:Male; D008657:Metabolic Clearance Rate; D008875:Middle Aged; D009928:Organ Specificity; D019275:Radiopharmaceuticals / Q000493:pharmacokinetics; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013667:Technetium / Q000493:pharmacokinetics*; D013959:Thyroid Diseases / Q000000981:diagnostic imaging / Q000378:metabolism*; D014018:Tissue Distribution
chemical_list: D007457:Iodine Radioisotopes; D019275:Radiopharmaceuticals; D013667:Technetium
keywords: Technetium uptake; benign thyroid diseases; iodine supply; radioiodine therapy