title: Circumferential optical coherence tomography angiography imaging of the swine esophagus using a micromotor balloon catheter.
abstract: We demonstrate a micromotor balloon imaging catheter for ultrahigh speed endoscopic optical coherence tomography (OCT) which provides wide area, circumferential structural and angiographic imaging of the esophagus without contrast agents. Using a 1310 nm MEMS tunable wavelength swept VCSEL light source, the system has a 1.2 MHz A-scan rate and ~8.5 µm axial resolution in tissue. The micromotor balloon catheter enables circumferential imaging of the esophagus at 240 frames per second (fps) with a ~30 µm (FWHM) spot size. Volumetric imaging is achieved by proximal pullback of the micromotor assembly within the balloon at 1.5 mm/sec. Volumetric data consisting of 4200 circumferential images of 5,000 A-scans each over a 2.6 cm length, covering a ~13 cm(2) area is acquired in <18 seconds. A non-rigid image registration algorithm is used to suppress motion artifacts from non-uniform rotational distortion (NURD), cardiac motion or respiration. En face OCT images at various depths can be generated. OCT angiography (OCTA) is computed using intensity decorrelation between sequential pairs of circumferential scans and enables three-dimensional visualization of vasculature. Wide area volumetric OCT and OCTA imaging of the swine esophagus in vivo is demonstrated.
authors: Department of Electrical Engineering & Computer Science and Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge MA, USA.
authors: Hsiang-Chieh
authors: HC
authors: Lee
authors: Department of Electrical Engineering & Computer Science and Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge MA, USA.
authors: Osman Oguz
authors: OO
authors: Ahsen
authors: Department of Electrical Engineering & Computer Science and Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge MA, USA.
authors: Kaicheng
authors: K
authors: Liang
authors: Department of Electrical Engineering & Computer Science and Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge MA, USA.
authors: Zhao
authors: Z
authors: Wang
authors: Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge MA, USA; Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge MA, USA; Brigham and Women's Hospital, Boston MA, USA.
authors: Cody
authors: C
authors: Cleveland
authors: Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge MA, USA; Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge MA, USA.
authors: Lucas
authors: L
authors: Booth
authors: Department of Electrical Engineering & Computer Science and Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge MA, USA; Advanced Imaging Group, Thorlabs Inc., Newton NJ, USA.
authors: Benjamin
authors: B
authors: Potsaid
authors: Praevium Research Inc., Santa Barbara CA, USA.
authors: Vijaysekhar
authors: V
authors: Jayaraman
authors: Advanced Imaging Group, Thorlabs Inc., Newton NJ, USA.
authors: Alex E
authors: AE
authors: Cable
authors: Harvard Medical School, Boston, MA, USA; Veterans Affairs Boston Healthcare System, Boston MA, USA.
authors: Hiroshi
authors: H
authors: Mashimo
authors: Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge MA, USA; Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge MA, USA.
authors: Robert
authors: R
authors: Langer
authors: Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge MA, USA; Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge MA, USA; Brigham and Women's Hospital, Boston MA, USA; Harvard Medical School, Boston, MA, USA.
authors: Giovanni
authors: G
authors: Traverso
authors: Department of Electrical Engineering & Computer Science and Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge MA, USA.
authors: James G
authors: JG
authors: Fujimoto
keywords: (110.6880) Three-dimensional image acquisition; (170.2150) Endoscopic imaging; (170.2680) Gastrointestinal; (170.3880) Medical and biological imaging; (170.4500) Optical coherence tomography