title: Desmoplastic Small Round Cell Tumor of the Pleura Successfully Treated with a Lower Dose of Pazopanib.
abstract: Desmoplastic small round cell tumor (DSRCT) is an aggressive mesenchymal tumor which primarily affects the abdomen. Even a multimodal approach rarely achieves durable remission and the optimal therapy for extended disease is unknown. We herein describe a rare case of DSRCT arising from the pleura in a 32-year-old man. Initial therapy, which included chemotherapy, surgery and radiotherapy, achieved a partial response for only two months. Although salvage chemotherapies had no effect, pazopanib treatment shrank the tumors and was well-tolerated on an outpatient basis. From the viewpoint of quality of life, pazopanib may therefore be a good therapeutic option for this aggressive disease.
authors: Department of Respiratory Medicine, Japanese Red Cross Wakayama Medical Center, Japan.
authors: Tatsuyoshi
authors: T
authors: Ikeue
authors: Issei
authors: I
authors: Ohi
authors: Susumu
authors: S
authors: Noguchi
authors: Akari
authors: A
authors: Fukao
authors: Satoshi
authors: S
authors: Terashita
authors: Sadao
authors: S
authors: Horikawa
authors: Takakazu
authors: T
authors: Sugita
mesh_terms: D000328:Adult; D020533:Angiogenesis Inhibitors / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D058405:Desmoplastic Small Round Cell Tumor / Q000188:drug therapy*; D006801:Humans; D007191:Indazoles; D008297:Male; D010997:Pleural Neoplasms / Q000188:drug therapy*; D011743:Pyrimidines / Q000627:therapeutic use*; D011788:Quality of Life; D013449:Sulfonamides / Q000627:therapeutic use*
chemical_list: D020533:Angiogenesis Inhibitors; D007191:Indazoles; D011743:Pyrimidines; D013449:Sulfonamides; C516667:pazopanib