title: A Retrospective Observational Study to Assess Prescription Pattern in Patients with Type B Aortic Dissection and Treatment Outcome.
abstract: Aortic dissection is a life-threatening condition. However, the use of medication to treat it remains unclear in our population, particularly in patients with a type B aortic dissection (TBAD) who do not receive surgery. This retrospective cohort study evaluated antihypertensive prescription patterns and outcomes in patients with nonsurgical TBAD. We reviewed the hospital records of patients with TBAD at a medical center in Taiwan from January 2008 to June 2013 to assess the baseline information, prescribing pattern, event rate, and clinical effectiveness of different antihypertensive treatment strategies. A Cox proportional hazards model was used to estimate outcomes in different antihypertensive strategies. The primary endpoints were all-cause mortality and hospital admission for an aortic dissection. We included 106 patients with a mean follow-up period of 2.75 years. The most common comorbidity was hypertension followed by dyslipidemia and diabetes mellitus. Study endpoints mostly occurred within 6 months after the index date. Over 80% of patients received dual or triple antihypertensive strategies. Patients treated with different treatment strategies did not have a significantly increased risk of a primary outcome compared with those treated with a monotherapy. We found no significant difference in the primary outcome following the use of different antihypertensive medication regimes.
authors: Department of Internal Medicine, Chi Mei Medical Center, Chiali, No. 606, Jialixing, Jiali District, Tainan 72263, Taiwan.
authors: Kuang-Ming
authors: 0000-0003-4364-8248
authors: KM
authors: Liao
authors: Department of Pharmacy, Kaohsiung Medical University Hospital, No. 100, Tzyou 1st Road, Sanmin District, Kaohsiung 80708, Taiwan; School of Pharmacy, Master Program in Clinical Pharmacy, Kaohsiung Medical University, No. 100, Shih-Chuan 1st Road, Sanmin District, Kaohsiung 80708, Taiwan.
authors: Chung-Yu
authors: 0000-0001-7206-3957
authors: CY
authors: Chen
authors: Department of Pharmacy, Kaohsiung Medical University Hospital, No. 100, Tzyou 1st Road, Sanmin District, Kaohsiung 80708, Taiwan.
authors: Shih-Han
authors: SH
authors: Wang
authors: Division of Cardiovascular Surgery, Department of Surgery, Kaohsiung Medical University Hospital, No. 100, Tzyou 1st Road, Sanmin District, Kaohsiung 80708, Taiwan.
authors: Jiann-Woei
authors: JW
authors: Huang
authors: Department of Pharmacy, Kaohsiung Medical University Hospital, No. 100, Tzyou 1st Road, Sanmin District, Kaohsiung 80708, Taiwan.
authors: Chen-Chun
authors: 0000-0001-5464-5056
authors: CC
authors: Kuo
authors: Department of Pharmacy, Kaohsiung Medical University Hospital, No. 100, Tzyou 1st Road, Sanmin District, Kaohsiung 80708, Taiwan; School of Pharmacy, Master Program in Clinical Pharmacy, Kaohsiung Medical University, No. 100, Shih-Chuan 1st Road, Sanmin District, Kaohsiung 80708, Taiwan.
authors: Yaw-Bin
authors: 0000-0002-6024-0108
authors: YB
authors: Huang
mesh_terms: D000368:Aged; D000959:Antihypertensive Agents / Q000008:administration & dosage*; D017545:Aortic Aneurysm, Thoracic / Q000150:complications / Q000188:drug therapy* / Q000401:mortality / Q000473:pathology; D003920:Diabetes Mellitus / Q000401:mortality / Q000473:pathology; D050171:Dyslipidemias / Q000401:mortality / Q000473:pathology; D005260:Female; D006753:Hospital Records; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000188:drug therapy* / Q000401:mortality / Q000473:pathology; D008297:Male; D008875:Middle Aged; D010818:Practice Patterns, Physicians'; D012189:Retrospective Studies; D013624:Taiwan; D016896:Treatment Outcome
chemical_list: D000959:Antihypertensive Agents