title: Cross-protection induced by Toxoplasma gondii virus-like particle vaccine upon intraperitoneal route challenge.
abstract: The inner membrane complex sub-compartment has a critical role in Toxoplasma gondii endodyogeny. In this study, we investigated the protection upon intraperitoneal route (IP) challenge induced by the virus-like particles (VLPs) vaccine containing Toxoplasma gondii IMC ISP (RH strain) (Type I). Intranasal immunization with the VLPs in mice elicited enhanced systemic and mucosal Toxoplasma gondii-specific IgG, IgG1, IgG2a and IgA antibody responses, and CD4+ and CD8+ responses. Immunized mice significantly reduced T. gondii cyst burden and size in brain, resulting in cross-protection upon T. gondii (ME49) (Type II) challenge infection. These results indicate that the IP route challenge infection induced by T. gondii IMC ISP VLPs might be a very good target for vaccination representing novel approach to reduce infection.
authors: Department of Biomedical Science, Graduate School, Kyung Hee University, Seoul, Republic of Korea.
authors: Dong-Hun
authors: DH
authors: Lee
authors: Department of Biomedical Science, Graduate School, Kyung Hee University, Seoul, Republic of Korea.
authors: Ah-Ra
authors: AR
authors: Kim
authors: Department of Biomedical Science, Graduate School, Kyung Hee University, Seoul, Republic of Korea.
authors: Su-Hwa
authors: SH
authors: Lee
authors: Department of Medical Zoology, Kyung Hee University School of Medicine, Seoul, Republic of Korea. Electronic address: fsquan@khu.ac.kr.
authors: Fu-Shi
authors: FS
authors: Quan
mesh_terms: D000818:Animals; D007274:Injections, Intraperitoneal; D008807:Mice, Inbred BALB C; D016052:Protozoan Vaccines / Q000008:administration & dosage*; D014122:Toxoplasma / Q000276:immunology*; D014124:Toxoplasmosis, Animal / Q000276:immunology; D058425:Vaccines, Virus-Like Particle / Q000008:administration & dosage*
chemical_list: D016052:Protozoan Vaccines; D058425:Vaccines, Virus-Like Particle
keywords: Inner membrane complex; Protection; Toxoplasma gondii; Vaccine; Virus-like particle