title: Decrease of Delta Oscillatory Responses in Cognitively Normal Parkinson's Disease.
abstract: Parkinson's disease (PD) is a common progressive neurodegenerative disorder. This study aims to compare sensory-evoked oscillations (SEOs) and event-related oscillations (EROs) of visual modality in cognitively normal PD patients and healthy controls. Sixteen PD and 16 age-, gender-, and education-matched healthy controls participated in the study. A simple flashlight was used for SEO and a classical visual oddball paradigm was used for target ERO. Oscillatory responses in the delta frequency range (0.5-3.5 Hz) were examined. Significantly lower delta ERO and SEO responses were found in PD patients than healthy controls. Delta ERO responses were decreased at all frontal, central and parietal locations, whereas delta SEO responses were decreased over mid and right central locations in PD. According to the notion that SEO reflects the activity of sensory networks and ERO reflects cognitive networks, these findings indicate that PD patients have impairments in both cognitive and sensory networks of visual modality. Decreased delta ERO responses indicate that the subliminal cognitive changes in PD can be detected by electrophysiological methods. These results demonstrate that brain oscillatory responses have the potential to be studied as a biomarker for visual cognitive and sensory networks in PD.
authors: 1 Department of Psychology, Dokuz Eylül University, Izmir, Turkey.|2 Department of Neurosciences, Dokuz Eylül University, Izmir, Turkey.
authors: Derya Durusu
authors: DD
authors: Emek-Savaş
authors: 2 Department of Neurosciences, Dokuz Eylül University, Izmir, Turkey.
authors: Gülin
authors: G
authors: Özmüş
authors: 3 Department of Biophysics, Istanbul Medipol University, Istanbul, Turkey.
authors: Bahar
authors: B
authors: Güntekin
authors: 4 Department of Neurology, Dokuz Eylül University Medical School, Izmir, Turkey.
authors: Berril
authors: B
authors: Dönmez Çolakoğlu
authors: 4 Department of Neurology, Dokuz Eylül University Medical School, Izmir, Turkey.|5 Brain Dynamics Multidisciplinary Research Center, Dokuz Eylül University, Izmir, Turkey.
authors: Raif
authors: R
authors: Çakmur
authors: 6 Brain Dynamics, Cognition and Complex Systems Research Center, Istanbul Kultur University, Istanbul, Turkey.
authors: Erol
authors: E
authors: Başar
authors: 2 Department of Neurosciences, Dokuz Eylül University, Izmir, Turkey.|4 Department of Neurology, Dokuz Eylül University Medical School, Izmir, Turkey.|5 Brain Dynamics Multidisciplinary Research Center, Dokuz Eylül University, Izmir, Turkey.|6 Brain Dynamics, Cognition and Complex Systems Research Center, Istanbul Kultur University, Istanbul, Turkey.|7 Izmir International Biomedicine and Genome Institute, Dokuz Eylül University Health Campus, Izmir, Turkey.
authors: Görsev G
authors: GG
authors: Yener
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000503:physiopathology*; D015415:Biomarkers / Q000032:analysis; D001921:Brain / Q000502:physiology / Q000503:physiopathology; D003071:Cognition / Q000502:physiology; D060825:Cognitive Dysfunction / Q000209:etiology / Q000503:physiopathology*; D003700:Delta Rhythm / Q000502:physiology; D004569:Electroencephalography; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000150:complications / Q000175:diagnosis / Q000503:physiopathology*
chemical_list: D015415:Biomarkers
keywords: P300; Parkinson’s disease; event-related oscillations; sensory-evoked oscillations