title: A role of CB1R in inducing θ-rhythm coordination between the gustatory and gastrointestinal insula.
abstract: Anandamide (AEA) and N-oleoylethanolamine (OEA) are produced in the intestine and brain during fasting and satiety, respectively. Subsequently, AEA facilitates food intake via activation of cannabinoid type-1 receptors (CB1Rs) while OEA decreases food intake via activation of peroxisome proliferator-activated receptor-α (PPARα) and/or G-protein-coupled receptor 119 (GPR119). Neuronal activity in the gastrointestinal region of the autonomic insula (GI-Au-I) that rostrally adjoins the gustatory insula (Gu-I) increases during fasting, enhancing appetite while umami and sweet taste sensations in Gu-I enhances appetite in GI-Au-I, strongly suggesting the presence of a neural interaction between the Gu-I and GI-Au-I which changes depending on the concentrations of AEA and OEA. However, this possibility has never been investigated. In rat slice preparations, we demonstrate with voltage-sensitive dye imaging that activation of CB1Rs by AEA induces θ-rhythm oscillatory synchronization in the Gu-I which propagates into the GI-Au-I but stops at its caudal end, displaying an oscillatory coordination. The AEA-induced oscillation was abolished by a CB1R antagonist or OEA through activation of GPR119. Our results demonstrate that the neural coordination between the Gu-I and GI-Au-I is generated or suppressed by the opposing activities between CB1R and GPR119. This mechanism may be involved in the feeding behavior based on taste recognition.
authors: Department of Neuroscience and Oral Physiology, Osaka University Graduate School of Dentistry, Suita, Osaka 565-0871, Japan.
authors: Youngnam
authors: Y
authors: Kang
authors: Department of Neuroscience and Oral Physiology, Osaka University Graduate School of Dentistry, Suita, Osaka 565-0871, Japan.
authors: Hajime
authors: H
authors: Sato
authors: Department of Neuroscience and Oral Physiology, Osaka University Graduate School of Dentistry, Suita, Osaka 565-0871, Japan.|Department of Oral Physiology, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima 890-8544, Japan.
authors: Mitsuru
authors: M
authors: Saito
authors: Department of Neuroscience and Oral Physiology, Osaka University Graduate School of Dentistry, Suita, Osaka 565-0871, Japan.
authors: Dong Xu
authors: DX
authors: Yin
authors: Department of Oral Anatomy and Neurobiology, BK21, School of Dentistry, Kyungpook National University, Daegu 700-412, Republic of Korea.
authors: Sook Kyung
authors: SK
authors: Park
authors: Department of Neurobiology and Physiology, School of Dentistry, Seoul National University, Seoul 110-749, Republic of Korea.
authors: Seog Bae
authors: SB
authors: Oh
authors: Department of Oral Anatomy and Neurobiology, BK21, School of Dentistry, Kyungpook National University, Daegu 700-412, Republic of Korea.
authors: Yong Chul
authors: YC
authors: Bae
authors: Department of Neuroscience and Oral Physiology, Osaka University Graduate School of Dentistry, Suita, Osaka 565-0871, Japan.
authors: Hiroki
authors: H
authors: Toyoda
mesh_terms: D000429:Alcohol Oxidoreductases / Q000235:genetics* / Q000378:metabolism; D000818:Animals; D001066:Appetite / Q000502:physiology; D001095:Arachidonic Acids / Q000378:metabolism; D002540:Cerebral Cortex / Q000502:physiology; D004435:Eating / Q000502:physiology; D063388:Endocannabinoids / Q000378:metabolism; D004983:Ethanolamines / Q000378:metabolism; D005215:Fasting / Q000502:physiology*; D005247:Feeding Behavior / Q000502:physiology; D005260:Female; D015870:Gene Expression; D007422:Intestines / Q000502:physiology; D008297:Male; D009474:Neurons / Q000166:cytology / Q000378:metabolism; D009829:Oleic Acids / Q000378:metabolism; D053284:Polyunsaturated Alkamides / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D017208:Rats, Wistar; D043562:Receptors, G-Protein-Coupled / Q000235:genetics* / Q000378:metabolism; D012527:Satiation / Q000502:physiology*; D015398:Signal Transduction; D055697:Taste Perception / Q000502:physiology*; D013826:Theta Rhythm / Q000502:physiology*
chemical_list: D001095:Arachidonic Acids; D063388:Endocannabinoids; D004983:Ethanolamines; C532423:GPR119 protein, rat; D009829:Oleic Acids; D053284:Polyunsaturated Alkamides; D043562:Receptors, G-Protein-Coupled; C033595:N-oleoylethanolamine; D000429:Alcohol Oxidoreductases; C555915:carbonyl reductase 1, mouse; C078814:anandamide