title: DNA Nanostructures Carrying Stoichiometrically Definable Antibodies.
abstract: Targeted drug delivery is one of the key challenges in cancer nanomedicine. Stoichiometric and spatial control over the antibodies placement on the nanomedicine vehicle holds a pivotal role to overcome this key challenge. Here, a DNA tetrahedral is designed with available conjugation sites on its vertices, allowing to bind one, two, or three cetuximab antibodies per DNA nanostructure. This stoichiometrically definable cetuximab conjugated DNA nanostructure shows enhanced targeting on the breast cancer cells, which results with higher overall killing efficacy of the cancer cells.
authors: Department of Chemical and Biomolecular Engineering, National University of Singapore, 4 Engineering Drive 4, Singapore, 117585, Singapore.
authors: Magdiel Inggrid
authors: MI
authors: Setyawati
authors: Department of Chemical and Biomolecular Engineering, National University of Singapore, 4 Engineering Drive 4, Singapore, 117585, Singapore.|Faculty of Chemical and Natural Resources Engineering, University Malaysia Pahang, Tun Razak Highway, 26300, Kuantan, Pahang, Malaysia.
authors: Rajaletchumy Veloo
authors: RV
authors: Kutty
authors: Department of Chemical and Biomolecular Engineering, National University of Singapore, 4 Engineering Drive 4, Singapore, 117585, Singapore. cheltwd@nus.edu.sg.
authors: David Tai
authors: DT
authors: Leong
mesh_terms: D000818:Animals; D000906:Antibodies / Q000378:metabolism*; D016923:Cell Death / Q000187:drug effects; D045744:Cell Line, Tumor; D000068818:Cetuximab / Q000494:pharmacology; D004247:DNA / Q000737:chemistry*; D004317:Doxorubicin / Q000494:pharmacology; D065546:Drug Liberation; D004705:Endocytosis / Q000187:drug effects; D006801:Humans; D020128:Inhibitory Concentration 50; D051379:Mice; D041681:NIH 3T3 Cells; D049329:Nanostructures / Q000737:chemistry*
chemical_list: D000906:Antibodies; D004317:Doxorubicin; D004247:DNA; D000068818:Cetuximab
keywords: DNA nanostructures; cancer nanomedicine; targeted drug delivery