title: The correlation between plasma levels of oxytocin and betatrophin in non-diabetic and diabetic metabolic syndrome patients: A cross sectional study from Jordan.
abstract: BACKGROUND
  Oxytocin (OXT) is a neurohypophyseal hormone that has been recently shown to possess a number of beneficial effects in diabetes and obesity. Betatrophin is a protein expressed in fat and liver that regulates lipid metabolism and promotes pancreatic β-cell proliferation. It is not investigated yet whether OXT and betatrophin levels correlate in metabolic syndrome (MS) or diabetes patients.
  
  
  METHODS
  The aim was to assess correlations between plasma betatrophin and OXT levels in MS-diabetic or prediabetic (N=89) as compared to MS-non-diabetic (N=69) patients. Competitive binding ELISA was used to evaluate betatrophin and OXT plasma concentrations. Correlations of the above biomarkers and patient clinical characteristics were also detected.
  
  
  RESULTS
  As compared to the control MS participants (0.32±0.25ng/mL); betatrophin plasma levels were increased (P<0.001) in the MS-pre/T2DM patients (1.23±0.68ng/mL). On the contrary, OXT concentrations were decreased (P<0.001) in the MS-pre/T2DM patients (1222.46±514.55pg/mL) as compared to the MS control subjects (2323.42±848.68pg/mL). OXT concentration correlated negatively (r=-0.492, P<0.001), while HbA1c and FPG correlated positively with betatrophin plasma levels (P<0.001), but were inversely correlated with OXT levels (P<0.001) in the total sample.
  
  
  CONCLUSIONS
  Betatrophin levels are increased, while OXT levels are decreased in MS-pre/T2DM. We found an inverse correlation between the levels of the two biomarkers in addition to correlation between their levels and the degree of glycemic control.
authors: School of Pharmacy, The University of Jordan, PO Box 11942, Amman, Jordan; Jordan University Hospital, The University of Jordan, PO Box 11942, Amman, Jordan.
authors: Amani
authors: A
authors: Al-Rawashdeh
authors: School of Pharmacy, The University of Jordan, PO Box 11942, Amman, Jordan; Jordan University Hospital, The University of Jordan, PO Box 11942, Amman, Jordan. Electronic address: violetk70@gmail.com.
authors: Violet
authors: V
authors: Kasabri
authors: School of Pharmacy, The University of Jordan, PO Box 11942, Amman, Jordan; Jordan University Hospital, The University of Jordan, PO Box 11942, Amman, Jordan.
authors: Nailya
authors: N
authors: Bulatova
authors: School of Pharmacy, The University of Jordan, PO Box 11942, Amman, Jordan; Jordan University Hospital, The University of Jordan, PO Box 11942, Amman, Jordan.
authors: Amal
authors: A
authors: Akour
authors: School of Pharmacy, The University of Jordan, PO Box 11942, Amman, Jordan; Jordan University Hospital, The University of Jordan, PO Box 11942, Amman, Jordan.
authors: Ayman
authors: A
authors: Zayed
authors: School of Pharmacy, The University of Jordan, PO Box 11942, Amman, Jordan; Jordan University Hospital, The University of Jordan, PO Box 11942, Amman, Jordan.
authors: Munther
authors: M
authors: Momani
authors: National Center for Diabetes, Endocrinology and Genetics, Queen Rania Street, ox Amman 13165, Jordan.
authors: Nahla
authors: N
authors: Khawaja
authors: National Center for Diabetes, Endocrinology and Genetics, Queen Rania Street, ox Amman 13165, Jordan.
authors: Haider
authors: H
authors: Bustanji
authors: National Center for Diabetes, Endocrinology and Genetics, Queen Rania Street, ox Amman 13165, Jordan.
authors: Dana
authors: D
authors: Hyasat
mesh_terms: D000293:Adolescent; D000328:Adult; D000091306:Angiopoietin-Like Protein 8; D000075802:Angiopoietin-like Proteins; D015415:Biomarkers / Q000097:blood*; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D003924:Diabetes Mellitus, Type 2 / Q000150:complications*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood* / Q000209:etiology; D008875:Middle Aged; D010121:Oxytocin / Q000097:blood*; D036361:Peptide Hormones / Q000097:blood*; D011379:Prognosis; D055815:Young Adult
chemical_list: C576683:ANGPTL8 protein, human; D000091306:Angiopoietin-Like Protein 8; D000075802:Angiopoietin-like Proteins; D015415:Biomarkers; D036361:Peptide Hormones; D010121:Oxytocin
keywords: Betatrophin; Enzyme linked immunosorbent assays; Metabolic syndrome; Oxytocin; Type 2 diabetes mellitus