title: Endoscopic Treatment of Early Barrett's Neoplasia: Expanding Indications, New Challenges.
abstract: Endoscopic therapy of early Barrett's neoplasia is nowadays the treatment of choice and recommended over surgery in most current guidelines. Recent data suggest radiofrequency ablation of low-grade intraepithelial neoplasia when confirmed by an expert pathologist. Endoscopic therapy of high-grade intraepithelial neoplasia and mucosal Barrett's adenocarcinoma consists of two steps: first endoscopic resection of all visible lesions, and second ablation of the remaining flat Barrett's mucosa to reduce the rate of recurrences and metachronous neoplasia. The preferred ablation method is radiofrequency ablation. In case of Barrett's adenocarcinoma with incipient submucosal invasion, endoscopic treatment can be considered curative when there are no further risk factors present.
authors: Department of Gastroenterology and Interventional Endoscopy, St. John of God Hospital Regensburg, Teaching Hospital of the University of Regensburg, Pruefeninger Str. 86, Regensburg, D-93049, Germany. oliver.pech@barmherzige-regensburg.de.
authors: Oliver
authors: O
authors: Pech
mesh_terms: D000230:Adenocarcinoma / Q000000981:diagnostic imaging / Q000601:surgery*; D001471:Barrett Esophagus / Q000000981:diagnostic imaging / Q000601:surgery*; D017115:Catheter Ablation / Q000379:methods; D055088:Early Detection of Cancer; D004938:Esophageal Neoplasms / Q000000981:diagnostic imaging / Q000601:surgery*; D004945:Esophagoscopy / Q000379:methods*; D006801:Humans; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity
keywords: Argon-plasma coagulation; Barrett’s esophagus; Endoscopic resection; Esophageal cancer; Photodynamic therapy; Radiofrequency ablation