title: Economic Incentives for Antibacterial Drug Development: Literature Review and Considerations From the Transatlantic Task Force on Antimicrobial Resistance.
abstract: The Trans-Atlantic Task Force on Antimicrobial Resistance (TATFAR) in 2015 was tasked with exploring economic incentives for antibacterial drug development and providing recommendations for potential global implementation. Due to the continual decline of pharmaceutical companies investing in new antibiotic development and the rise in antimicrobial resistance, there is an urgent need to examine market mechanisms that are appropriate to encourage small, medium, and large companies to reinvest in this space. This review provides a summary of the various models that have been proposed and highlights positions posed by several policy documents, peer-reviewed publications, organization proposals, and government-sponsored reviews. The findings support a form of a de-linkage model and a combination of push and pull incentive mechanisms. This level of consensus could culminate in global coordination of incentives that strike a balance of rewarding innovation and ensuring appropriate antibiotic use.
authors: Division of Chemical, Biological, Radiological and Nuclear Countermeasures, Biomedical Advanced Research and Development Authority, Office of Assistant Secretary for Preparedness and Response, US Department of Health and Human Services, Washington D.C.
authors: Kimberly
authors: K
authors: Sciarretta
authors: Infection Control and Environmental Health, Norwegian Institute of Public Health, and Institute of Health and Society, University of Oslo, Norway.
authors: John-Arne
authors: JA
authors: Røttingen
authors: Directorate General for Health and Food Safety.
authors: Aleksandra
authors: A
authors: Opalska
authors: Directorate Health, Directorate General for Research and Innovation, European Commission, Brussels, Belgium.
authors: Arjon J
authors: AJ
authors: Van Hengel
authors: Biomedical Advanced Research and Development Authority, Office of Assistant Secretary for Preparedness and Response, US Department of Health and Human Services, Washington D.C.
authors: Joseph
authors: J
authors: Larsen
mesh_terms: D026683:Advisory Committees; D000900:Anti-Bacterial Agents; D055808:Drug Discovery / Q000191:economics*; D004345:Drug Industry / Q000191:economics; D024881:Drug Resistance, Bacterial; D006801:Humans; D009042:Motivation
chemical_list: D000900:Anti-Bacterial Agents
keywords: TATFAR; antibiotic resistance; antimicrobials; economic incentives