title: Functional Membrane Microdomains Organize Signaling Networks in Bacteria.
abstract: Membrane organization is usually associated with the correct function of a number of cellular processes in eukaryotic cells as diverse as signal transduction, protein sorting, membrane trafficking, or pathogen invasion. It has been recently discovered that bacterial membranes are able to compartmentalize their signal transduction pathways in functional membrane microdomains (FMMs). In this review article, we discuss the biological significance of the existence of FMMs in bacteria and comment on possible beneficial roles that FMMs play on the harbored signal transduction cascades. Moreover, four different membrane-associated signal transduction cascades whose functions are linked to the integrity of FMMs are introduced, and the specific role that FMMs play in stabilizing and promoting interactions of their signaling components is discussed. Altogether, FMMs seem to play a relevant role in promoting more efficient activation of signal transduction cascades in bacterial cells and show that bacteria are more sophisticated organisms than previously appreciated.
authors: Research Centre for Infectious Diseases (ZINF), University of Würzburg, 97080, Würzburg, Germany.|Institute for Molecular Infection Biology (IMIB), University of Würzburg, 97080, Würzburg, Germany.|National Center for Biotechnology (CNB), Spanish Research Council (CSIC), Universidad Autonoma de Madrid, Darwin 3, Campus de Cantoblanco, 28050, Madrid, Spain.
authors: Rabea M
authors: RM
authors: Wagner
authors: Research Centre for Infectious Diseases (ZINF), University of Würzburg, 97080, Würzburg, Germany.|Institute for Molecular Infection Biology (IMIB), University of Würzburg, 97080, Würzburg, Germany.|National Center for Biotechnology (CNB), Spanish Research Council (CSIC), Universidad Autonoma de Madrid, Darwin 3, Campus de Cantoblanco, 28050, Madrid, Spain.
authors: Lara
authors: L
authors: Kricks
authors: Research Centre for Infectious Diseases (ZINF), University of Würzburg, 97080, Würzburg, Germany. dlopez@cnb.csic.es.|Institute for Molecular Infection Biology (IMIB), University of Würzburg, 97080, Würzburg, Germany. dlopez@cnb.csic.es.|National Center for Biotechnology (CNB), Spanish Research Council (CSIC), Universidad Autonoma de Madrid, Darwin 3, Campus de Cantoblanco, 28050, Madrid, Spain. dlopez@cnb.csic.es.
authors: Daniel
authors: D
authors: Lopez
mesh_terms: D049069:ATP-Dependent Proteases / Q000235:genetics / Q000378:metabolism; D001412:Bacillus subtilis / Q000235:genetics / Q000378:metabolism* / Q000648:ultrastructure; D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism; D018441:Biofilms / Q000254:growth & development*; D002451:Cell Compartmentation; D002473:Cell Wall / Q000737:chemistry / Q000378:metabolism; D004926:Escherichia coli / Q000235:genetics / Q000378:metabolism* / Q000648:ultrastructure; D029968:Escherichia coli Proteins / Q000235:genetics / Q000378:metabolism; D015964:Gene Expression Regulation, Bacterial; D008563:Membrane Lipids / Q000737:chemistry / Q000378:metabolism; D021962:Membrane Microdomains / Q000737:chemistry / Q000378:metabolism*; D008565:Membrane Proteins / Q000235:genetics / Q000378:metabolism; D009713:Nucleotidyltransferases / Q000235:genetics / Q000378:metabolism; D055503:Protein Multimerization; D012097:Repressor Proteins / Q000235:genetics / Q000378:metabolism; D015398:Signal Transduction
chemical_list: D001426:Bacterial Proteins; D029968:Escherichia coli Proteins; D008563:Membrane Lipids; D008565:Membrane Proteins; D012097:Repressor Proteins; C106354:flotillins; C061279:PhoR protein, Bacteria; C051296:resD protein, E coli; C061064:PhoP protein, Bacteria; D009713:Nucleotidyltransferases; D049069:ATP-Dependent Proteases; C513383:FtsH protein, E coli
keywords: Bacterial membranes; Membrane microdomains; Signal transduction