title: Pre-hospital management, procedural performance and outcomes for primary percutaneous coronary intervention in ST-elevation myocardial infarction in the Netherlands: Insights from the Dutch cohort of the APPOSITION-III trial.
abstract: OBJECTIVE
  The aim of this study was to achieve useful insights into pre-hospital management and procedural performance for ST-elevation myocardial infarction (STEMI) in the Netherlands by extrapolating patient characteristics, and procedural and clinical outcomes of the Dutch patient cohort from the APPOSITION-III trial.
  
  
  METHODS
  This is a retrospective analysis from the APPOSITION-III trial with respect to the geographical borders of STEMI management. The APPOSITION-III trial was a European registry for the use of the STENTYS self-expandable stent in STEMI patients undergoing primary percutaneous coronary intervention (PPCI). 965 Patients were enrolled mainly in the Netherlands (n = 420, 43.5 % of the overall study population), Germany (n = 165) and France (n = 131). The data from the Dutch cohort were compared with both the overall study population, and the French and German cohorts, respectively, as well as the European Society of Cardiology (ESC) STEMI guidelines.
  
  
  RESULTS
  In this trial there was a wide inter-country variation on symptom-to-balloon time, 165 minutes (120-318) in the Netherlands, 270 minutes (180-650) in Germany and 360 minutes (120-480) in France, respectively. In general, a preload of dual antiplatelet therapy (DAPT) combined with heparin was more often performed in the Dutch and French cohort than in the German cohort. DAPT at discharge was high across the whole APPOSITION-III population. No important differences were seen between the different groups according to the endpoints major adverse cardiac event and stent thrombosis.
  
  
  CONCLUSIONS
  In the Dutch cohort of an European multicentre STEMI study (APPOSITION-III trial), the performance in terms of symptom-to-balloon time, and pre-, peri- and post-procedural medical treatment is in line with the recommendations of ESC STEMI guidelines.
authors: Onze Lieve Vrouwe Gasthuis, Amsterdam, The Netherlands.
authors: N S
authors: NS
authors: Vos
authors: Onze Lieve Vrouwe Gasthuis, Amsterdam, The Netherlands. g.amoroso@olvg.nl.
authors: G
authors: G
authors: Amoroso
authors: Academic Medical Center, Amsterdam, The Netherlands.
authors: M J
authors: MJ
authors: Grundeken
authors: Albert Schweitzer Hospital, Dordrecht, The Netherlands.
authors: A J J
authors: AJ
authors: Ijsselmuiden
authors: Erasmus Medical Center, Rotterdam, The Netherlands.
authors: R J M
authors: RJ
authors: van Geuns
authors: STENTYS S.A., Paris, France.
authors: R
authors: R
authors: Spaargaren
authors: Academic Medical Center, Amsterdam, The Netherlands.
authors: J G P
authors: JG
authors: Tijssen
authors: Academic Medical Center, Amsterdam, The Netherlands.
authors: K T
authors: KT
authors: Koch
keywords: Primary percutaneous coronary intervention; ST-elevation myocardial infarction