title: PDGF-D gene polymorphism is associated with increased cardiovascular mortality in elderly men.
abstract: Platelet-derived growth factor (PDGF) D has been reported to be active in fibroblasts, and in areas of myocardial infarction. In this longitudinal study we evaluated the association between PDGF-D polymorphism and cardiovascular mortality, and attempted to discover whether specific genotype differences regarding risk could be observed, and if gender differences could be seen.
  
  
  
  Four hundred seventy-six elderly community participants were included in this study. All participants underwent a clinical examination, echocardiography, and blood sampling including PDGF-D single nucleotide polymorphism (SNP) analyses of the rs974819 A/A, G/A and G/G SNP. The follow-up time was 6.7 years.
  
  
  
  No specific genotype of rs974819 demonstrated increased cardiovascular mortality in the total population, however, the male group with genotypes A/A and G/A demonstrated an increased risk that persisted in a multivariate evaluation where adjustments were made for well-known cardiovascular risk factors (2.7 fold compared with the G/G genotype). No corresponding finding was observed in the female group.
  
  
  
  We report here for the first time that the genotypes G/A or A/A of the SNP rs974819 near PDGF-D exhibited a 2.7 fold increased cardiovascular mortality risk in males. Corresponding increased risk could not be observed in either the total population and thus not in the female group. However, the sample size is was small and the results should be regarded as hypothesis-generating, and thus more research in the field is recommended.
authors: Department of Cardiology, University Hospital of Linköping, SE-581 85, Linköping, Sweden. urban.alehagen@liu.se.|Department of Medical and Health Sciences, Linköping University, Linköping, Sweden. urban.alehagen@liu.se.
authors: Urban
authors: U
authors: Alehagen
authors: Division of Drug Research, Department of Medical and Health Sciences, Faculty of Health Sciences, Linköping University, Linköping, Sweden.|Department of Laboratory Services, County Hospital Ryhov, Jönköping, Sweden.
authors: Renate S
authors: RS
authors: Olsen
authors: Division of Drug Research, Department of Medical and Health Sciences, Faculty of Health Sciences, Linköping University, Linköping, Sweden.|Department of Medical and Health Sciences, Division of Cardiovascular Medicine/Physiology, University of Linköping, 581 85, Linköping, Sweden.
authors: Toste
authors: T
authors: Länne
authors: Department of Laboratory Services, County Hospital Ryhov, Jönköping, Sweden.
authors: Andreas
authors: A
authors: Matussek
authors: Division of Drug Research, Department of Medical and Health Sciences, Faculty of Health Sciences, Linköping University, Linköping, Sweden.|Department of Medical and Health Sciences, Division of Drug Research/Clinical Pharmacology, University of Linköping, 581 85, Linköping, Sweden.
authors: Dick
authors: D
authors: Wågsäter
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D015992:Body Mass Index; D002318:Cardiovascular Diseases / Q000235:genetics* / Q000401:mortality* / Q000473:pathology; D004452:Echocardiography; D005260:Female; D005838:Genotype; D006321:Heart / Q000000981:diagnostic imaging; D006801:Humans; D053208:Kaplan-Meier Estimate; D008222:Lymphokines / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D010982:Platelet-Derived Growth Factor / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D016016:Proportional Hazards Models; D012307:Risk Factors; D012737:Sex Factors; D013318:Stroke Volume
chemical_list: D008222:Lymphokines; C427493:PDGFD protein, human; D010982:Platelet-Derived Growth Factor
keywords: Cardiovascular risk; Gender; Genotypes; PDGF-D; Prognosis; rs974819