title: Gain-of-function Prolactin Receptor Variants Are Not Associated With Breast Cancer and Multiple Fibroadenoma Risk.
abstract: In a cohort of 95 women with multiple breast fibroadenomas (MFAs), we recently identified patients harboring germline heterozygous variants of the prolactin receptor (PRLR) exhibiting constitutive activity (PRLRI146Land PRLRI176V).
  
  
  
  This study sought to better delineate the potential role of PRLR gain-of-function variants in benign and malignant mammary tumorigenesis.
  
  
  
  This was an observational study and transgenic mouse model analysis.
  
  
  
  The study took place at the Department of Endocrinology, Reproductive Disorders and Rare Gynecologic Diseases, Pitié Salpêtrière, Paris, and Inserm Unit 1151, Paris.
  
  
  
  We generated a second MFA cohort (n = 71) as well as a group of control subjects (n = 496) and a cohort of women with breast cancer (n = 119). We also generated two transgenic mouse models carrying the coding sequences of human PRLRI146Lor PRLRWT.
  
  
  
  We aimed to determine the prevalence of PRLR variants in these three populations and to uncover any association of the latter with specific tumor pattern, especially in patients with breast cancer.
  
  
  
  This study did not highlight a higher prevalence of PRLR variants in the MFA group and in the breast cancer group compared with control subjects. Transgenic mice expressing PRLRI146Lexhibited very mild histological mammary phenotype but tumors were never observed.
  
  
  
  PRLRI146Land PRLRI176Vvariants are not associated with breast cancer or MFA risk. However, one cannot exclude that low but sustained PRLR signaling may facilitate or contribute to pathological development driven by oncogenic pathways. Long-term patient follow-up should help to address this issue.
authors: Institut E3M-ICAN, Department of Endocrinology and Reproductive Medicine (Z.C., C.C., V.Gr., I.T., P.T.), Hôpitaux Universitaires Pitié Salpêtrière Charles Foix, Centre des Pathologies Gynécologiques Rares, Firendo, Université Pierre et Marie Curie, 75013 Paris, France; Department of Oncological Surgery (F.L.), Institut Curie, 75005 Paris, France; Inserm (M.B., I.C., A.C., N.P., S.B., F.B., P.C., J.-E.G., V.G., P.T.), U1151, Institut Necker Enfants Malades, 75993 Paris, France; Université Paris Descartes (M.B., I.C., A.C., N.P., S.B., F.B., M.F., M.D.C., R.P., J.-E. G., V.G.), Sorbonne Paris Cité, France; Department of Genetics (I.B., S.V.), Institut Curie, 75005 Paris, France; Unite de Recherche Clinique (M.-L.T., A.B.), Pitie Salpêtriere Hospital, 75013 Paris, France; Inserm (M.F., M.D.C.), U1016, Institut Cochin, 75014 Paris, France; CNRS (M.F., M.D.C., R.P.), UMR8104, Paris, France; Inter Régional pour la Santé (F.R., J.T.), La Riche, France; and Department of Pathology (B.S.-Z.), Institut Curie, 75005 Paris, France.
authors: Zeina
authors: Z
authors: Chakhtoura
authors: Institut E3M-ICAN, Department of Endocrinology and Reproductive Medicine (Z.C., C.C., V.Gr., I.T., P.T.), Hôpitaux Universitaires Pitié Salpêtrière Charles Foix, Centre des Pathologies Gynécologiques Rares, Firendo, Université Pierre et Marie Curie, 75013 Paris, France; Department of Oncological Surgery (F.L.), Institut Curie, 75005 Paris, France; Inserm (M.B., I.C., A.C., N.P., S.B., F.B., P.C., J.-E.G., V.G., P.T.), U1151, Institut Necker Enfants Malades, 75993 Paris, France; Université Paris Descartes (M.B., I.C., A.C., N.P., S.B., F.B., M.F., M.D.C., R.P., J.-E. G., V.G.), Sorbonne Paris Cité, France; Department of Genetics (I.B., S.V.), Institut Curie, 75005 Paris, France; Unite de Recherche Clinique (M.-L.T., A.B.), Pitie Salpêtriere Hospital, 75013 Paris, France; Inserm (M.F., M.D.C.), U1016, Institut Cochin, 75014 Paris, France; CNRS (M.F., M.D.C., R.P.), UMR8104, Paris, France; Inter Régional pour la Santé (F.R., J.T.), La Riche, France; and Department of Pathology (B.S.-Z.), Institut Curie, 75005 Paris, France.
authors: Fatima
authors: F
authors: Laki
authors: Institut E3M-ICAN, Department of Endocrinology and Reproductive Medicine (Z.C., C.C., V.Gr., I.T., P.T.), Hôpitaux Universitaires Pitié Salpêtrière Charles Foix, Centre des Pathologies Gynécologiques Rares, Firendo, Université Pierre et Marie Curie, 75013 Paris, France; Department of Oncological Surgery (F.L.), Institut Curie, 75005 Paris, France; Inserm (M.B., I.C., A.C., N.P., S.B., F.B., P.C., J.-E.G., V.G., P.T.), U1151, Institut Necker Enfants Malades, 75993 Paris, France; Université Paris Descartes (M.B., I.C., A.C., N.P., S.B., F.B., M.F., M.D.C., R.P., J.-E. G., V.G.), Sorbonne Paris Cité, France; Department of Genetics (I.B., S.V.), Institut Curie, 75005 Paris, France; Unite de Recherche Clinique (M.-L.T., A.B.), Pitie Salpêtriere Hospital, 75013 Paris, France; Inserm (M.F., M.D.C.), U1016, Institut Cochin, 75014 Paris, France; CNRS (M.F., M.D.C., R.P.), UMR8104, Paris, France; Inter Régional pour la Santé (F.R., J.T.), La Riche, France; and Department of Pathology (B.S.-Z.), Institut Curie, 75005 Paris, France.
authors: Marie
authors: M
authors: Bernadet
authors: Institut E3M-ICAN, Department of Endocrinology and Reproductive Medicine (Z.C., C.C., V.Gr., I.T., P.T.), Hôpitaux Universitaires Pitié Salpêtrière Charles Foix, Centre des Pathologies Gynécologiques Rares, Firendo, Université Pierre et Marie Curie, 75013 Paris, France; Department of Oncological Surgery (F.L.), Institut Curie, 75005 Paris, France; Inserm (M.B., I.C., A.C., N.P., S.B., F.B., P.C., J.-E.G., V.G., P.T.), U1151, Institut Necker Enfants Malades, 75993 Paris, France; Université Paris Descartes (M.B., I.C., A.C., N.P., S.B., F.B., M.F., M.D.C., R.P., J.-E. G., V.G.), Sorbonne Paris Cité, France; Department of Genetics (I.B., S.V.), Institut Curie, 75005 Paris, France; Unite de Recherche Clinique (M.-L.T., A.B.), Pitie Salpêtriere Hospital, 75013 Paris, France; Inserm (M.F., M.D.C.), U1016, Institut Cochin, 75014 Paris, France; CNRS (M.F., M.D.C., R.P.), UMR8104, Paris, France; Inter Régional pour la Santé (F.R., J.T.), La Riche, France; and Department of Pathology (B.S.-Z.), Institut Curie, 75005 Paris, France.
authors: Ibtissem
authors: I
authors: Cherifi
authors: Institut E3M-ICAN, Department of Endocrinology and Reproductive Medicine (Z.C., C.C., V.Gr., I.T., P.T.), Hôpitaux Universitaires Pitié Salpêtrière Charles Foix, Centre des Pathologies Gynécologiques Rares, Firendo, Université Pierre et Marie Curie, 75013 Paris, France; Department of Oncological Surgery (F.L.), Institut Curie, 75005 Paris, France; Inserm (M.B., I.C., A.C., N.P., S.B., F.B., P.C., J.-E.G., V.G., P.T.), U1151, Institut Necker Enfants Malades, 75993 Paris, France; Université Paris Descartes (M.B., I.C., A.C., N.P., S.B., F.B., M.F., M.D.C., R.P., J.-E. G., V.G.), Sorbonne Paris Cité, France; Department of Genetics (I.B., S.V.), Institut Curie, 75005 Paris, France; Unite de Recherche Clinique (M.-L.T., A.B.), Pitie Salpêtriere Hospital, 75013 Paris, France; Inserm (M.F., M.D.C.), U1016, Institut Cochin, 75014 Paris, France; CNRS (M.F., M.D.C., R.P.), UMR8104, Paris, France; Inter Régional pour la Santé (F.R., J.T.), La Riche, France; and Department of Pathology (B.S.-Z.), Institut Curie, 75005 Paris, France.
authors: Aurélie
authors: A
authors: Chiche
authors: Institut E3M-ICAN, Department of Endocrinology and Reproductive Medicine (Z.C., C.C., V.Gr., I.T., P.T.), Hôpitaux Universitaires Pitié Salpêtrière Charles Foix, Centre des Pathologies Gynécologiques Rares, Firendo, Université Pierre et Marie Curie, 75013 Paris, France; Department of Oncological Surgery (F.L.), Institut Curie, 75005 Paris, France; Inserm (M.B., I.C., A.C., N.P., S.B., F.B., P.C., J.-E.G., V.G., P.T.), U1151, Institut Necker Enfants Malades, 75993 Paris, France; Université Paris Descartes (M.B., I.C., A.C., N.P., S.B., F.B., M.F., M.D.C., R.P., J.-E. G., V.G.), Sorbonne Paris Cité, France; Department of Genetics (I.B., S.V.), Institut Curie, 75005 Paris, France; Unite de Recherche Clinique (M.-L.T., A.B.), Pitie Salpêtriere Hospital, 75013 Paris, France; Inserm (M.F., M.D.C.), U1016, Institut Cochin, 75014 Paris, France; CNRS (M.F., M.D.C., R.P.), UMR8104, Paris, France; Inter Régional pour la Santé (F.R., J.T.), La Riche, France; and Department of Pathology (B.S.-Z.), Institut Curie, 75005 Paris, France.
authors: Natascha
authors: N
authors: Pigat
authors: Institut E3M-ICAN, Department of Endocrinology and Reproductive Medicine (Z.C., C.C., V.Gr., I.T., P.T.), Hôpitaux Universitaires Pitié Salpêtrière Charles Foix, Centre des Pathologies Gynécologiques Rares, Firendo, Université Pierre et Marie Curie, 75013 Paris, France; Department of Oncological Surgery (F.L.), Institut Curie, 75005 Paris, France; Inserm (M.B., I.C., A.C., N.P., S.B., F.B., P.C., J.-E.G., V.G., P.T.), U1151, Institut Necker Enfants Malades, 75993 Paris, France; Université Paris Descartes (M.B., I.C., A.C., N.P., S.B., F.B., M.F., M.D.C., R.P., J.-E. G., V.G.), Sorbonne Paris Cité, France; Department of Genetics (I.B., S.V.), Institut Curie, 75005 Paris, France; Unite de Recherche Clinique (M.-L.T., A.B.), Pitie Salpêtriere Hospital, 75013 Paris, France; Inserm (M.F., M.D.C.), U1016, Institut Cochin, 75014 Paris, France; CNRS (M.F., M.D.C., R.P.), UMR8104, Paris, France; Inter Régional pour la Santé (F.R., J.T.), La Riche, France; and Department of Pathology (B.S.-Z.), Institut Curie, 75005 Paris, France.
authors: Sophie
authors: S
authors: Bernichtein
authors: Institut E3M-ICAN, Department of Endocrinology and Reproductive Medicine (Z.C., C.C., V.Gr., I.T., P.T.), Hôpitaux Universitaires Pitié Salpêtrière Charles Foix, Centre des Pathologies Gynécologiques Rares, Firendo, Université Pierre et Marie Curie, 75013 Paris, France; Department of Oncological Surgery (F.L.), Institut Curie, 75005 Paris, France; Inserm (M.B., I.C., A.C., N.P., S.B., F.B., P.C., J.-E.G., V.G., P.T.), U1151, Institut Necker Enfants Malades, 75993 Paris, France; Université Paris Descartes (M.B., I.C., A.C., N.P., S.B., F.B., M.F., M.D.C., R.P., J.-E. G., V.G.), Sorbonne Paris Cité, France; Department of Genetics (I.B., S.V.), Institut Curie, 75005 Paris, France; Unite de Recherche Clinique (M.-L.T., A.B.), Pitie Salpêtriere Hospital, 75013 Paris, France; Inserm (M.F., M.D.C.), U1016, Institut Cochin, 75014 Paris, France; CNRS (M.F., M.D.C., R.P.), UMR8104, Paris, France; Inter Régional pour la Santé (F.R., J.T.), La Riche, France; and Department of Pathology (B.S.-Z.), Institut Curie, 75005 Paris, France.
authors: Carine
authors: C
authors: Courtillot
authors: Institut E3M-ICAN, Department of Endocrinology and Reproductive Medicine (Z.C., C.C., V.Gr., I.T., P.T.), Hôpitaux Universitaires Pitié Salpêtrière Charles Foix, Centre des Pathologies Gynécologiques Rares, Firendo, Université Pierre et Marie Curie, 75013 Paris, France; Department of Oncological Surgery (F.L.), Institut Curie, 75005 Paris, France; Inserm (M.B., I.C., A.C., N.P., S.B., F.B., P.C., J.-E.G., V.G., P.T.), U1151, Institut Necker Enfants Malades, 75993 Paris, France; Université Paris Descartes (M.B., I.C., A.C., N.P., S.B., F.B., M.F., M.D.C., R.P., J.-E. G., V.G.), Sorbonne Paris Cité, France; Department of Genetics (I.B., S.V.), Institut Curie, 75005 Paris, France; Unite de Recherche Clinique (M.-L.T., A.B.), Pitie Salpêtriere Hospital, 75013 Paris, France; Inserm (M.F., M.D.C.), U1016, Institut Cochin, 75014 Paris, France; CNRS (M.F., M.D.C., R.P.), UMR8104, Paris, France; Inter Régional pour la Santé (F.R., J.T.), La Riche, France; and Department of Pathology (B.S.-Z.), Institut Curie, 75005 Paris, France.
authors: Florence
authors: F
authors: Boutillon
authors: Institut E3M-ICAN, Department of Endocrinology and Reproductive Medicine (Z.C., C.C., V.Gr., I.T., P.T.), Hôpitaux Universitaires Pitié Salpêtrière Charles Foix, Centre des Pathologies Gynécologiques Rares, Firendo, Université Pierre et Marie Curie, 75013 Paris, France; Department of Oncological Surgery (F.L.), Institut Curie, 75005 Paris, France; Inserm (M.B., I.C., A.C., N.P., S.B., F.B., P.C., J.-E.G., V.G., P.T.), U1151, Institut Necker Enfants Malades, 75993 Paris, France; Université Paris Descartes (M.B., I.C., A.C., N.P., S.B., F.B., M.F., M.D.C., R.P., J.-E. G., V.G.), Sorbonne Paris Cité, France; Department of Genetics (I.B., S.V.), Institut Curie, 75005 Paris, France; Unite de Recherche Clinique (M.-L.T., A.B.), Pitie Salpêtriere Hospital, 75013 Paris, France; Inserm (M.F., M.D.C.), U1016, Institut Cochin, 75014 Paris, France; CNRS (M.F., M.D.C., R.P.), UMR8104, Paris, France; Inter Régional pour la Santé (F.R., J.T.), La Riche, France; and Department of Pathology (B.S.-Z.), Institut Curie, 75005 Paris, France.
authors: Ivan
authors: I
authors: Bièche
authors: Institut E3M-ICAN, Department of Endocrinology and Reproductive Medicine (Z.C., C.C., V.Gr., I.T., P.T.), Hôpitaux Universitaires Pitié Salpêtrière Charles Foix, Centre des Pathologies Gynécologiques Rares, Firendo, Université Pierre et Marie Curie, 75013 Paris, France; Department of Oncological Surgery (F.L.), Institut Curie, 75005 Paris, France; Inserm (M.B., I.C., A.C., N.P., S.B., F.B., P.C., J.-E.G., V.G., P.T.), U1151, Institut Necker Enfants Malades, 75993 Paris, France; Université Paris Descartes (M.B., I.C., A.C., N.P., S.B., F.B., M.F., M.D.C., R.P., J.-E. G., V.G.), Sorbonne Paris Cité, France; Department of Genetics (I.B., S.V.), Institut Curie, 75005 Paris, France; Unite de Recherche Clinique (M.-L.T., A.B.), Pitie Salpêtriere Hospital, 75013 Paris, France; Inserm (M.F., M.D.C.), U1016, Institut Cochin, 75014 Paris, France; CNRS (M.F., M.D.C., R.P.), UMR8104, Paris, France; Inter Régional pour la Santé (F.R., J.T.), La Riche, France; and Department of Pathology (B.S.-Z.), Institut Curie, 75005 Paris, France.
authors: Sophie
authors: S
authors: Vacher
authors: Institut E3M-ICAN, Department of Endocrinology and Reproductive Medicine (Z.C., C.C., V.Gr., I.T., P.T.), Hôpitaux Universitaires Pitié Salpêtrière Charles Foix, Centre des Pathologies Gynécologiques Rares, Firendo, Université Pierre et Marie Curie, 75013 Paris, France; Department of Oncological Surgery (F.L.), Institut Curie, 75005 Paris, France; Inserm (M.B., I.C., A.C., N.P., S.B., F.B., P.C., J.-E.G., V.G., P.T.), U1151, Institut Necker Enfants Malades, 75993 Paris, France; Université Paris Descartes (M.B., I.C., A.C., N.P., S.B., F.B., M.F., M.D.C., R.P., J.-E. G., V.G.), Sorbonne Paris Cité, France; Department of Genetics (I.B., S.V.), Institut Curie, 75005 Paris, France; Unite de Recherche Clinique (M.-L.T., A.B.), Pitie Salpêtriere Hospital, 75013 Paris, France; Inserm (M.F., M.D.C.), U1016, Institut Cochin, 75014 Paris, France; CNRS (M.F., M.D.C., R.P.), UMR8104, Paris, France; Inter Régional pour la Santé (F.R., J.T.), La Riche, France; and Department of Pathology (B.S.-Z.), Institut Curie, 75005 Paris, France.
authors: Marie-Laure
authors: ML
authors: Tanguy
authors: Institut E3M-ICAN, Department of Endocrinology and Reproductive Medicine (Z.C., C.C., V.Gr., I.T., P.T.), Hôpitaux Universitaires Pitié Salpêtrière Charles Foix, Centre des Pathologies Gynécologiques Rares, Firendo, Université Pierre et Marie Curie, 75013 Paris, France; Department of Oncological Surgery (F.L.), Institut Curie, 75005 Paris, France; Inserm (M.B., I.C., A.C., N.P., S.B., F.B., P.C., J.-E.G., V.G., P.T.), U1151, Institut Necker Enfants Malades, 75993 Paris, France; Université Paris Descartes (M.B., I.C., A.C., N.P., S.B., F.B., M.F., M.D.C., R.P., J.-E. G., V.G.), Sorbonne Paris Cité, France; Department of Genetics (I.B., S.V.), Institut Curie, 75005 Paris, France; Unite de Recherche Clinique (M.-L.T., A.B.), Pitie Salpêtriere Hospital, 75013 Paris, France; Inserm (M.F., M.D.C.), U1016, Institut Cochin, 75014 Paris, France; CNRS (M.F., M.D.C., R.P.), UMR8104, Paris, France; Inter Régional pour la Santé (F.R., J.T.), La Riche, France; and Department of Pathology (B.S.-Z.), Institut Curie, 75005 Paris, France.
authors: Anne
authors: A
authors: Bissery
authors: Institut E3M-ICAN, Department of Endocrinology and Reproductive Medicine (Z.C., C.C., V.Gr., I.T., P.T.), Hôpitaux Universitaires Pitié Salpêtrière Charles Foix, Centre des Pathologies Gynécologiques Rares, Firendo, Université Pierre et Marie Curie, 75013 Paris, France; Department of Oncological Surgery (F.L.), Institut Curie, 75005 Paris, France; Inserm (M.B., I.C., A.C., N.P., S.B., F.B., P.C., J.-E.G., V.G., P.T.), U1151, Institut Necker Enfants Malades, 75993 Paris, France; Université Paris Descartes (M.B., I.C., A.C., N.P., S.B., F.B., M.F., M.D.C., R.P., J.-E. G., V.G.), Sorbonne Paris Cité, France; Department of Genetics (I.B., S.V.), Institut Curie, 75005 Paris, France; Unite de Recherche Clinique (M.-L.T., A.B.), Pitie Salpêtriere Hospital, 75013 Paris, France; Inserm (M.F., M.D.C.), U1016, Institut Cochin, 75014 Paris, France; CNRS (M.F., M.D.C., R.P.), UMR8104, Paris, France; Inter Régional pour la Santé (F.R., J.T.), La Riche, France; and Department of Pathology (B.S.-Z.), Institut Curie, 75005 Paris, France.
authors: Virginie
authors: V
authors: Grouthier
authors: Institut E3M-ICAN, Department of Endocrinology and Reproductive Medicine (Z.C., C.C., V.Gr., I.T., P.T.), Hôpitaux Universitaires Pitié Salpêtrière Charles Foix, Centre des Pathologies Gynécologiques Rares, Firendo, Université Pierre et Marie Curie, 75013 Paris, France; Department of Oncological Surgery (F.L.), Institut Curie, 75005 Paris, France; Inserm (M.B., I.C., A.C., N.P., S.B., F.B., P.C., J.-E.G., V.G., P.T.), U1151, Institut Necker Enfants Malades, 75993 Paris, France; Université Paris Descartes (M.B., I.C., A.C., N.P., S.B., F.B., M.F., M.D.C., R.P., J.-E. G., V.G.), Sorbonne Paris Cité, France; Department of Genetics (I.B., S.V.), Institut Curie, 75005 Paris, France; Unite de Recherche Clinique (M.-L.T., A.B.), Pitie Salpêtriere Hospital, 75013 Paris, France; Inserm (M.F., M.D.C.), U1016, Institut Cochin, 75014 Paris, France; CNRS (M.F., M.D.C., R.P.), UMR8104, Paris, France; Inter Régional pour la Santé (F.R., J.T.), La Riche, France; and Department of Pathology (B.S.-Z.), Institut Curie, 75005 Paris, France.
authors: Philippe
authors: P
authors: Camparo
authors: Institut E3M-ICAN, Department of Endocrinology and Reproductive Medicine (Z.C., C.C., V.Gr., I.T., P.T.), Hôpitaux Universitaires Pitié Salpêtrière Charles Foix, Centre des Pathologies Gynécologiques Rares, Firendo, Université Pierre et Marie Curie, 75013 Paris, France; Department of Oncological Surgery (F.L.), Institut Curie, 75005 Paris, France; Inserm (M.B., I.C., A.C., N.P., S.B., F.B., P.C., J.-E.G., V.G., P.T.), U1151, Institut Necker Enfants Malades, 75993 Paris, France; Université Paris Descartes (M.B., I.C., A.C., N.P., S.B., F.B., M.F., M.D.C., R.P., J.-E. G., V.G.), Sorbonne Paris Cité, France; Department of Genetics (I.B., S.V.), Institut Curie, 75005 Paris, France; Unite de Recherche Clinique (M.-L.T., A.B.), Pitie Salpêtriere Hospital, 75013 Paris, France; Inserm (M.F., M.D.C.), U1016, Institut Cochin, 75014 Paris, France; CNRS (M.F., M.D.C., R.P.), UMR8104, Paris, France; Inter Régional pour la Santé (F.R., J.T.), La Riche, France; and Department of Pathology (B.S.-Z.), Institut Curie, 75005 Paris, France.
authors: Marc
authors: M
authors: Foretz
authors: Institut E3M-ICAN, Department of Endocrinology and Reproductive Medicine (Z.C., C.C., V.Gr., I.T., P.T.), Hôpitaux Universitaires Pitié Salpêtrière Charles Foix, Centre des Pathologies Gynécologiques Rares, Firendo, Université Pierre et Marie Curie, 75013 Paris, France; Department of Oncological Surgery (F.L.), Institut Curie, 75005 Paris, France; Inserm (M.B., I.C., A.C., N.P., S.B., F.B., P.C., J.-E.G., V.G., P.T.), U1151, Institut Necker Enfants Malades, 75993 Paris, France; Université Paris Descartes (M.B., I.C., A.C., N.P., S.B., F.B., M.F., M.D.C., R.P., J.-E. G., V.G.), Sorbonne Paris Cité, France; Department of Genetics (I.B., S.V.), Institut Curie, 75005 Paris, France; Unite de Recherche Clinique (M.-L.T., A.B.), Pitie Salpêtriere Hospital, 75013 Paris, France; Inserm (M.F., M.D.C.), U1016, Institut Cochin, 75014 Paris, France; CNRS (M.F., M.D.C., R.P.), UMR8104, Paris, France; Inter Régional pour la Santé (F.R., J.T.), La Riche, France; and Department of Pathology (B.S.-Z.), Institut Curie, 75005 Paris, France.
authors: Marcio
authors: M
authors: Do Cruzeiro
authors: Institut E3M-ICAN, Department of Endocrinology and Reproductive Medicine (Z.C., C.C., V.Gr., I.T., P.T.), Hôpitaux Universitaires Pitié Salpêtrière Charles Foix, Centre des Pathologies Gynécologiques Rares, Firendo, Université Pierre et Marie Curie, 75013 Paris, France; Department of Oncological Surgery (F.L.), Institut Curie, 75005 Paris, France; Inserm (M.B., I.C., A.C., N.P., S.B., F.B., P.C., J.-E.G., V.G., P.T.), U1151, Institut Necker Enfants Malades, 75993 Paris, France; Université Paris Descartes (M.B., I.C., A.C., N.P., S.B., F.B., M.F., M.D.C., R.P., J.-E. G., V.G.), Sorbonne Paris Cité, France; Department of Genetics (I.B., S.V.), Institut Curie, 75005 Paris, France; Unite de Recherche Clinique (M.-L.T., A.B.), Pitie Salpêtriere Hospital, 75013 Paris, France; Inserm (M.F., M.D.C.), U1016, Institut Cochin, 75014 Paris, France; CNRS (M.F., M.D.C., R.P.), UMR8104, Paris, France; Inter Régional pour la Santé (F.R., J.T.), La Riche, France; and Department of Pathology (B.S.-Z.), Institut Curie, 75005 Paris, France.
authors: Rémi
authors: R
authors: Pierre
authors: Institut E3M-ICAN, Department of Endocrinology and Reproductive Medicine (Z.C., C.C., V.Gr., I.T., P.T.), Hôpitaux Universitaires Pitié Salpêtrière Charles Foix, Centre des Pathologies Gynécologiques Rares, Firendo, Université Pierre et Marie Curie, 75013 Paris, France; Department of Oncological Surgery (F.L.), Institut Curie, 75005 Paris, France; Inserm (M.B., I.C., A.C., N.P., S.B., F.B., P.C., J.-E.G., V.G., P.T.), U1151, Institut Necker Enfants Malades, 75993 Paris, France; Université Paris Descartes (M.B., I.C., A.C., N.P., S.B., F.B., M.F., M.D.C., R.P., J.-E. G., V.G.), Sorbonne Paris Cité, France; Department of Genetics (I.B., S.V.), Institut Curie, 75005 Paris, France; Unite de Recherche Clinique (M.-L.T., A.B.), Pitie Salpêtriere Hospital, 75013 Paris, France; Inserm (M.F., M.D.C.), U1016, Institut Cochin, 75014 Paris, France; CNRS (M.F., M.D.C., R.P.), UMR8104, Paris, France; Inter Régional pour la Santé (F.R., J.T.), La Riche, France; and Department of Pathology (B.S.-Z.), Institut Curie, 75005 Paris, France.
authors: Fabienne
authors: F
authors: Rakotozafy
authors: Institut E3M-ICAN, Department of Endocrinology and Reproductive Medicine (Z.C., C.C., V.Gr., I.T., P.T.), Hôpitaux Universitaires Pitié Salpêtrière Charles Foix, Centre des Pathologies Gynécologiques Rares, Firendo, Université Pierre et Marie Curie, 75013 Paris, France; Department of Oncological Surgery (F.L.), Institut Curie, 75005 Paris, France; Inserm (M.B., I.C., A.C., N.P., S.B., F.B., P.C., J.-E.G., V.G., P.T.), U1151, Institut Necker Enfants Malades, 75993 Paris, France; Université Paris Descartes (M.B., I.C., A.C., N.P., S.B., F.B., M.F., M.D.C., R.P., J.-E. G., V.G.), Sorbonne Paris Cité, France; Department of Genetics (I.B., S.V.), Institut Curie, 75005 Paris, France; Unite de Recherche Clinique (M.-L.T., A.B.), Pitie Salpêtriere Hospital, 75013 Paris, France; Inserm (M.F., M.D.C.), U1016, Institut Cochin, 75014 Paris, France; CNRS (M.F., M.D.C., R.P.), UMR8104, Paris, France; Inter Régional pour la Santé (F.R., J.T.), La Riche, France; and Department of Pathology (B.S.-Z.), Institut Curie, 75005 Paris, France.
authors: Jean
authors: J
authors: Tichet
authors: Institut E3M-ICAN, Department of Endocrinology and Reproductive Medicine (Z.C., C.C., V.Gr., I.T., P.T.), Hôpitaux Universitaires Pitié Salpêtrière Charles Foix, Centre des Pathologies Gynécologiques Rares, Firendo, Université Pierre et Marie Curie, 75013 Paris, France; Department of Oncological Surgery (F.L.), Institut Curie, 75005 Paris, France; Inserm (M.B., I.C., A.C., N.P., S.B., F.B., P.C., J.-E.G., V.G., P.T.), U1151, Institut Necker Enfants Malades, 75993 Paris, France; Université Paris Descartes (M.B., I.C., A.C., N.P., S.B., F.B., M.F., M.D.C., R.P., J.-E. G., V.G.), Sorbonne Paris Cité, France; Department of Genetics (I.B., S.V.), Institut Curie, 75005 Paris, France; Unite de Recherche Clinique (M.-L.T., A.B.), Pitie Salpêtriere Hospital, 75013 Paris, France; Inserm (M.F., M.D.C.), U1016, Institut Cochin, 75014 Paris, France; CNRS (M.F., M.D.C., R.P.), UMR8104, Paris, France; Inter Régional pour la Santé (F.R., J.T.), La Riche, France; and Department of Pathology (B.S.-Z.), Institut Curie, 75005 Paris, France.
authors: Isabelle
authors: I
authors: Tejedor
authors: Institut E3M-ICAN, Department of Endocrinology and Reproductive Medicine (Z.C., C.C., V.Gr., I.T., P.T.), Hôpitaux Universitaires Pitié Salpêtrière Charles Foix, Centre des Pathologies Gynécologiques Rares, Firendo, Université Pierre et Marie Curie, 75013 Paris, France; Department of Oncological Surgery (F.L.), Institut Curie, 75005 Paris, France; Inserm (M.B., I.C., A.C., N.P., S.B., F.B., P.C., J.-E.G., V.G., P.T.), U1151, Institut Necker Enfants Malades, 75993 Paris, France; Université Paris Descartes (M.B., I.C., A.C., N.P., S.B., F.B., M.F., M.D.C., R.P., J.-E. G., V.G.), Sorbonne Paris Cité, France; Department of Genetics (I.B., S.V.), Institut Curie, 75005 Paris, France; Unite de Recherche Clinique (M.-L.T., A.B.), Pitie Salpêtriere Hospital, 75013 Paris, France; Inserm (M.F., M.D.C.), U1016, Institut Cochin, 75014 Paris, France; CNRS (M.F., M.D.C., R.P.), UMR8104, Paris, France; Inter Régional pour la Santé (F.R., J.T.), La Riche, France; and Department of Pathology (B.S.-Z.), Institut Curie, 75005 Paris, France.
authors: Jacques-Emmanuel
authors: JE
authors: Guidotti
authors: Institut E3M-ICAN, Department of Endocrinology and Reproductive Medicine (Z.C., C.C., V.Gr., I.T., P.T.), Hôpitaux Universitaires Pitié Salpêtrière Charles Foix, Centre des Pathologies Gynécologiques Rares, Firendo, Université Pierre et Marie Curie, 75013 Paris, France; Department of Oncological Surgery (F.L.), Institut Curie, 75005 Paris, France; Inserm (M.B., I.C., A.C., N.P., S.B., F.B., P.C., J.-E.G., V.G., P.T.), U1151, Institut Necker Enfants Malades, 75993 Paris, France; Université Paris Descartes (M.B., I.C., A.C., N.P., S.B., F.B., M.F., M.D.C., R.P., J.-E. G., V.G.), Sorbonne Paris Cité, France; Department of Genetics (I.B., S.V.), Institut Curie, 75005 Paris, France; Unite de Recherche Clinique (M.-L.T., A.B.), Pitie Salpêtriere Hospital, 75013 Paris, France; Inserm (M.F., M.D.C.), U1016, Institut Cochin, 75014 Paris, France; CNRS (M.F., M.D.C., R.P.), UMR8104, Paris, France; Inter Régional pour la Santé (F.R., J.T.), La Riche, France; and Department of Pathology (B.S.-Z.), Institut Curie, 75005 Paris, France.
authors: Brigitte
authors: B
authors: Sigal-Zafrani
authors: Institut E3M-ICAN, Department of Endocrinology and Reproductive Medicine (Z.C., C.C., V.Gr., I.T., P.T.), Hôpitaux Universitaires Pitié Salpêtrière Charles Foix, Centre des Pathologies Gynécologiques Rares, Firendo, Université Pierre et Marie Curie, 75013 Paris, France; Department of Oncological Surgery (F.L.), Institut Curie, 75005 Paris, France; Inserm (M.B., I.C., A.C., N.P., S.B., F.B., P.C., J.-E.G., V.G., P.T.), U1151, Institut Necker Enfants Malades, 75993 Paris, France; Université Paris Descartes (M.B., I.C., A.C., N.P., S.B., F.B., M.F., M.D.C., R.P., J.-E. G., V.G.), Sorbonne Paris Cité, France; Department of Genetics (I.B., S.V.), Institut Curie, 75005 Paris, France; Unite de Recherche Clinique (M.-L.T., A.B.), Pitie Salpêtriere Hospital, 75013 Paris, France; Inserm (M.F., M.D.C.), U1016, Institut Cochin, 75014 Paris, France; CNRS (M.F., M.D.C., R.P.), UMR8104, Paris, France; Inter Régional pour la Santé (F.R., J.T.), La Riche, France; and Department of Pathology (B.S.-Z.), Institut Curie, 75005 Paris, France.
authors: Vincent
authors: V
authors: Goffin
authors: Institut E3M-ICAN, Department of Endocrinology and Reproductive Medicine (Z.C., C.C., V.Gr., I.T., P.T.), Hôpitaux Universitaires Pitié Salpêtrière Charles Foix, Centre des Pathologies Gynécologiques Rares, Firendo, Université Pierre et Marie Curie, 75013 Paris, France; Department of Oncological Surgery (F.L.), Institut Curie, 75005 Paris, France; Inserm (M.B., I.C., A.C., N.P., S.B., F.B., P.C., J.-E.G., V.G., P.T.), U1151, Institut Necker Enfants Malades, 75993 Paris, France; Université Paris Descartes (M.B., I.C., A.C., N.P., S.B., F.B., M.F., M.D.C., R.P., J.-E. G., V.G.), Sorbonne Paris Cité, France; Department of Genetics (I.B., S.V.), Institut Curie, 75005 Paris, France; Unite de Recherche Clinique (M.-L.T., A.B.), Pitie Salpêtriere Hospital, 75013 Paris, France; Inserm (M.F., M.D.C.), U1016, Institut Cochin, 75014 Paris, France; CNRS (M.F., M.D.C., R.P.), UMR8104, Paris, France; Inter Régional pour la Santé (F.R., J.T.), La Riche, France; and Department of Pathology (B.S.-Z.), Institut Curie, 75005 Paris, France.
authors: Philippe
authors: P
authors: Touraine
mesh_terms: D000293:Adolescent; D000328:Adult; D000818:Animals; D001943:Breast Neoplasms / Q000235:genetics*; D015331:Cohort Studies; D004195:Disease Models, Animal; D005260:Female; D018226:Fibroadenoma / Q000235:genetics*; D006801:Humans; D051379:Mice; D008810:Mice, Inbred C57BL; D008822:Mice, Transgenic; D008875:Middle Aged; D011981:Receptors, Prolactin / Q000235:genetics*; D055815:Young Adult
chemical_list: D011981:Receptors, Prolactin