title: The Multidisciplinary Management of Colorectal Cancer: Present and Future Paradigms.
abstract: As treatment strategies for patients with colorectal cancer advance, there has now become an ever-increasing need for multidisciplinary teams to care for these patients. Recent investigations into the timing and duration of perioperative therapy, as well as, the rise of molecular profiling have led to more systemic chemotherapeutic options. The most efficacious use, in terms of timing and patient selection, of these therapies in the setting of modern operative and radiotherapy techniques requires the generation of care teams discussing cases at multidisciplinary conferences. This review highlights the role of multidisciplinary team conferences, advances in perioperative chemotherapy, current clinical biomarkers, and emerging therapeutic agents for molecular subtypes of metastatic colon cancer. As our understanding of relevant molecular subtypes increases and as data becomes available on treatment response, the treatment of colorectal cancer will become more precise and effective.
authors: Department of Oncology, University of Wisconsin, Madison, Wisconsin; Division of Gastroenterology and Hepatology, Department of Medicine, University of Wisconsin, Madison, Wisconsin.
authors: Chelsie K
authors: CK
authors: Sievers
authors: Division of Hematology and Oncology, Department of Medicine, University of Wisconsin, Madison, Wisconsin.
authors: Jeremy D
authors: JD
authors: Kratz
authors: Division of Hematology and Oncology, Department of Medicine, University of Wisconsin, Madison, Wisconsin.
authors: Luke D
authors: LD
authors: Zurbriggen
authors: Division of Hematology and Oncology, Department of Medicine, University of Wisconsin, Madison, Wisconsin; University of Wisconsin Carbone Cancer Center, University of Wisconsin, Madison, Wisconsin.
authors: Noelle K
authors: NK
authors: LoConte
authors: Division of Hematology and Oncology, Department of Medicine, University of Wisconsin, Madison, Wisconsin; University of Wisconsin Carbone Cancer Center, University of Wisconsin, Madison, Wisconsin.
authors: Sam J
authors: SJ
authors: Lubner
authors: Division of Hematology and Oncology, Department of Medicine, University of Wisconsin, Madison, Wisconsin; University of Wisconsin Carbone Cancer Center, University of Wisconsin, Madison, Wisconsin.
authors: Natalya
authors: N
authors: Uboha
authors: Division of Hematology and Oncology, Department of Medicine, University of Wisconsin, Madison, Wisconsin; University of Wisconsin Carbone Cancer Center, University of Wisconsin, Madison, Wisconsin.
authors: Daniel
authors: D
authors: Mulkerin
authors: Department of Oncology, University of Wisconsin, Madison, Wisconsin; University of Wisconsin Carbone Cancer Center, University of Wisconsin, Madison, Wisconsin; William S Middleton Memorial Veterans Hospital, Madison, Wisconsin; Department of Pathology and Laboratory Medicine, University of Wisconsin, Madison, Wisconsin.
authors: Kristina A
authors: KA
authors: Matkowskyj
authors: Division of Hematology and Oncology, Department of Medicine, University of Wisconsin, Madison, Wisconsin; University of Wisconsin Carbone Cancer Center, University of Wisconsin, Madison, Wisconsin; William S Middleton Memorial Veterans Hospital, Madison, Wisconsin.
authors: Dustin A
authors: DA
authors: Deming
keywords: chemotherapy; colon cancer; rectal cancer