title: Bergamotane Sesquiterpenes with Alpha-Glucosidase Inhibitory Activity from the Plant Pathogenic Fungus Penicillium expansum.
abstract: Two new bergamotane sesquiterpene lactones, named expansolides C and D (1 and 2), together with two known compounds expansolides A and B (3 and 4), were isolated from the plant pathogenic fungus Penicillium expansum ACCC37275. The structures of the new compounds were established by detailed analyses of the spectroscopic data, especially 1D-, 2D-NMR, and HR-ESI-MS. In an in vitro bioassay, the epimeric mixture of expansolides C and D (1 and 2) (in a ratio of 2:1 at the temprature of the bioassay) exhibited more potent α-glucosidase inhibitory activity (IC50=0.50 ± 0.02 mm) as compared with the positive control acarbose (IC50= 1.90 ± 0.05 mm). To the best of our knowledge, it was the first report on the α-glucosidase inhibitory activity of bergamotane sesquiterpenes.
authors: College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou, 310014, P. R. China.|College of Life Science, Zhejiang Sci-Tech University, Hangzhou, 310018, P. R. China.
authors: You-Min
authors: YM
authors: Ying
authors: College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou, 310014, P. R. China.
authors: Cheng-An
authors: CA
authors: Fang
authors: College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou, 310014, P. R. China.
authors: Feng-Qi
authors: FQ
authors: Yao
authors: College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou, 310014, P. R. China.
authors: Yuan
authors: Y
authors: Yu
authors: College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou, 310014, P. R. China.
authors: Ying
authors: Y
authors: Shen
authors: College of Life Science, Zhejiang Sci-Tech University, Hangzhou, 310018, P. R. China.
authors: Zhuo-Ni
authors: ZN
authors: Hou
authors: Zhejiang Provincial People's Hospital, Hangzhou, 310014, P. R. China.
authors: Zhen
authors: Z
authors: Wang
authors: Zhejiang Provincial People's Hospital, Hangzhou, 310014, P. R. China.
authors: Wei
authors: W
authors: Zhang
authors: College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou, 310014, P. R. China.
authors: Wei-Guang
authors: WG
authors: Shan
authors: College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou, 310014, P. R. China.
authors: Zha-Jun
authors: ZJ
authors: Zhan
mesh_terms: D004791:Enzyme Inhibitors / Q000302:isolation & purification / Q000494:pharmacology; D020128:Inhibitory Concentration 50; D007783:Lactones / Q000302:isolation & purification / Q000494:pharmacology; D015394:Molecular Structure; D010407:Penicillium / Q000737:chemistry*; D012717:Sesquiterpenes / Q000302:isolation & purification / Q000494:pharmacology*; D000520:alpha-Glucosidases / Q000187:drug effects*
chemical_list: D004791:Enzyme Inhibitors; D007783:Lactones; D012717:Sesquiterpenes; D000520:alpha-Glucosidases
keywords: 
  Penicillium expansum
  ; Bergamotane; Expansolides C and D; Sesquiterpenes; α-Glucosidase inhibitory activities