title: The exposome in practice: Design of the EXPOsOMICS project.
abstract: EXPOsOMICS is a European Union funded project that aims to develop a novel approach to the assessment of exposure to high priority environmental pollutants, by characterizing the external and the internal components of the exposome. It focuses on air and water contaminants during critical periods of life. To this end, the project centres on 1) exposure assessment at the personal and population levels within existing European short and long-term population studies, exploiting available tools and methods which have been developed for personal exposure monitoring (PEM); and 2) multiple "omic" technologies for the analysis of biological samples (internal markers of external exposures). The search for the relationships between external exposures and global profiles of molecular features in the same individuals constitutes a novel advancement towards the development of "next generation exposure assessment" for environmental chemicals and their mixtures. The linkage with disease risks opens the way to what are defined here as 'exposome-wide association studies' (EWAS).
authors: MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London, UK. Electronic address: p.vineis@imperial.ac.uk.
authors: P
authors: P
authors: Vineis
authors: MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London, UK.
authors: M
authors: M
authors: Chadeau-Hyam
authors: Genedata AG, Basel, Switzerland.
authors: H
authors: H
authors: Gmuender
authors: MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London, UK.
authors: J
authors: J
authors: Gulliver
authors: International Agency for Research on Cancer (IARC), Lyon, France.
authors: Z
authors: Z
authors: Herceg
authors: Maastricht University, Department of Health Risk Analysis and Toxicology, Maastricht, Netherlands.
authors: J
authors: J
authors: Kleinjans
authors: Barcelona Institute for Global Health (ISGlobal), Barcelona, Spain.
authors: M
authors: M
authors: Kogevinas
authors: National Hellenic Research Foundation, Institute of Biology, Medicinal Chemistry and Biotechnology, Division of Organic and Medicinal Chemistry, Athens, Greece.
authors: S
authors: S
authors: Kyrtopoulos
authors: Barcelona Institute for Global Health (ISGlobal), Barcelona, Spain.
authors: M
authors: M
authors: Nieuwenhuijsen
authors: King's College London, Analytical and Environmental Sciences Division, MRC-PHE Centre for Environment and Health, London, UK.
authors: D H
authors: DH
authors: Phillips
authors: Swiss Tropical School of Public Health, Department of Epidemiology and Public Health, Basel, Switzerland and University of Basel, Basel, Switzerland.
authors: N
authors: N
authors: Probst-Hensch
authors: International Agency for Research on Cancer (IARC), Lyon, France.
authors: A
authors: A
authors: Scalbert
authors: Utrecht University, Institute for Risk Assessment Sciences, Environmental Epidemiology Division, Utrecht, Netherlands.
authors: R
authors: R
authors: Vermeulen
authors: International Agency for Research on Cancer (IARC), Lyon, France.
authors: C P
authors: CP
authors: Wild
mesh_terms: D000328:Adult; D000397:Air Pollution / Q000009:adverse effects / Q000032:analysis; D015415:Biomarkers / Q000032:analysis; D002648:Child; D004784:Environmental Monitoring / Q000379:methods*; D005060:Europe; D023281:Genomics; D006801:Humans; D012107:Research Design; D018570:Risk Assessment; D014876:Water Pollution / Q000009:adverse effects / Q000032:analysis
chemical_list: D015415:Biomarkers