title: Amyloid Imaging: Poised for Integration into Medical Practice.
abstract: Amyloid imaging represents a significant advance as an adjunct in the diagnosis of Alzheimer's disease (AD) because it is the first imaging modality that identifies in vivo changes known to be associated with the pathogenesis. Initially,11C-PIB was developed, which was the prototype for many18F compounds, including florbetapir, florbetaben, and flutemetamol, among others. Despite the high sensitivity and specificity of amyloid imaging, it is not commonly used in clinical practice, mainly because it is not reimbursed under current Center for Medicare and Medicaid Services guidelines in the USA. To guide the field in who would be most appropriate for the utility of amyloid positron emission tomography, current studies are underway [Imaging Dementia Evidence for Amyloid Scanning (IDEAS) Study] that will inform the field on the utilization of amyloid positron emission tomography in clinical practice. With the advent of monoclonal antibodies that specifically target amyloid antibody, there is an interest, possibly a mandate, to screen potential treatment recipients to ensure that they are suitable for treatment. In this review, we summarize progress in the field to date.
authors: St. Joseph's Hospital and Medical Center, 350 W. Thomas Road, Phoenix, AZ, 85013, USA.
authors: Keshav
authors: K
authors: Anand
authors: Alzhiemer's and Memory Disorders Division, Barrow Neurological Institute, 240 W. Thomas Road, Ste 301, Phoenix, AZ, 85013, USA. marwan.sabbagh@dignityhealh.org.
authors: Marwan
authors: M
authors: Sabbagh
mesh_terms: D000544:Alzheimer Disease / Q000000981:diagnostic imaging* / Q000378:metabolism*; D016229:Amyloid beta-Peptides / Q000378:metabolism*; D000814:Aniline Compounds; D052160:Benzothiazoles / Q000627:therapeutic use; D015415:Biomarkers / Q000378:metabolism; D001921:Brain / Q000000981:diagnostic imaging / Q000378:metabolism; D002986:Clinical Trials as Topic; D005026:Ethylene Glycols; D006801:Humans; D009570:Nitriles; D049268:Positron-Emission Tomography; D019275:Radiopharmaceuticals; D012680:Sensitivity and Specificity; D013267:Stilbenes; D013844:Thiazoles; D057170:Translational Research, Biomedical
chemical_list: C444520:2-(1-(6-((2-fluoroethyl)(methyl)amino)-2-naphthyl)ethylidene)malononitrile; C475519:2-(4'-(methylamino)phenyl)-6-hydroxybenzothiazole; D016229:Amyloid beta-Peptides; D000814:Aniline Compounds; D052160:Benzothiazoles; D015415:Biomarkers; D005026:Ethylene Glycols; D009570:Nitriles; D019275:Radiopharmaceuticals; D013267:Stilbenes; D013844:Thiazoles; C581552:flutemetamol; C545186:florbetapir; C527756:4-(N-methylamino)-4'-(2-(2-(2-fluoroethoxy)ethoxy)ethoxy)stilbene
keywords: Alzheimer’s disease; PET-CT; amyloid; imaging; therapeutics