title: Plasma IL-6/IL-10 Ratio and IL-8, LDH, and HBDH Level Predict the Severity and the Risk of Death in AIDS Patients with Pneumocystis Pneumonia.
abstract: Objective. To identify blood biomarkers to predict severity and mortality in AIDS PCP patients. Methods. Biomarkers including clinical parameters and plasma inflammatory cytokines were assessed in 32 HIV-infected patients with Pneumocystis pneumonia (PCP) at time of admission. Predictive value of the biomarkers for clinical severity and in-hospital mortality was evaluated by corresponding ROC curve. Results. Levels of CRP, WBC, LDH, HBDH, and Ferritin were significantly higher in the severe and nonsurvivor AIDS PCP patients. These important biochemical indicators have inverse correlation with oxygenation index, especially levels of LDH (P = 0.008, R (2) = 0.258), HBDH (P = 0.001, R (2) = 0.335), and Ferritin (P = 0.005, R (2) = 0.237). Plasma IL-8 and IL-6 levels were significantly higher in patients with PaO2/FiO2 ≤ 200 mmHg and nonsurvivors than in those with PaO2/FiO2 > 200 mmHg and survivors. Severe and nonsurvival groups showed higher ratio of mean IL-6/IL-10 level (1.78 ± 1.56, P < 0.001; 1.11 ± 0.72, P = 0.043), larger AUC (95% CI 0.781-1.000, P < 0.001; 95% CI 0.592-0.917, P = 0.043), and more significantly inverse correlation with the oxygenation index. Conclusion. Plasma IL-8, LDH, and HBDH levels and IL-6/IL-10 ratio could be helpful for early evaluation of the severity and predicting fatal outcomes in AIDS PCP patients.
authors: State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Zhejiang, Hangzhou 310006, China; The First Affiliated Hospital, School of Medicine, Zhejiang University, Zhejiang, Hangzhou 310006, China; Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Zhejiang, Hangzhou 310006, China.
authors: Jia
authors: J
authors: Sun
authors: State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Zhejiang, Hangzhou 310006, China; The First Affiliated Hospital, School of Medicine, Zhejiang University, Zhejiang, Hangzhou 310006, China; Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Zhejiang, Hangzhou 310006, China.
authors: Junwei
authors: J
authors: Su
authors: State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Zhejiang, Hangzhou 310006, China; The First Affiliated Hospital, School of Medicine, Zhejiang University, Zhejiang, Hangzhou 310006, China; Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Zhejiang, Hangzhou 310006, China.
authors: Yirui
authors: Y
authors: Xie
authors: Division of Infectious Diseases, Columbia University Medical Center, New York, NY 10032, USA.
authors: Michael T
authors: MT
authors: Yin
authors: State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Zhejiang, Hangzhou 310006, China; The First Affiliated Hospital, School of Medicine, Zhejiang University, Zhejiang, Hangzhou 310006, China; Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Zhejiang, Hangzhou 310006, China.
authors: Ying
authors: Y
authors: Huang
authors: State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Zhejiang, Hangzhou 310006, China; The First Affiliated Hospital, School of Medicine, Zhejiang University, Zhejiang, Hangzhou 310006, China; Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Zhejiang, Hangzhou 310006, China.
authors: Lijun
authors: L
authors: Xu
authors: State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Zhejiang, Hangzhou 310006, China; The First Affiliated Hospital, School of Medicine, Zhejiang University, Zhejiang, Hangzhou 310006, China; Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Zhejiang, Hangzhou 310006, China.
authors: Qihui
authors: Q
authors: Zhou
authors: State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Zhejiang, Hangzhou 310006, China; The First Affiliated Hospital, School of Medicine, Zhejiang University, Zhejiang, Hangzhou 310006, China; Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Zhejiang, Hangzhou 310006, China.
authors: Biao
authors: 0000-0001-6288-4575
authors: B
authors: Zhu
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000097:blood* / Q000150:complications* / Q000175:diagnosis / Q000401:mortality; D000328:Adult; D015415:Biomarkers / Q000097:blood*; D005260:Female; D006801:Humans; D018836:Inflammation Mediators / Q000097:blood; D016753:Interleukin-10 / Q000097:blood; D015850:Interleukin-6 / Q000097:blood; D016209:Interleukin-8 / Q000097:blood; D045022:Lactate Dehydrogenases / Q000097:blood; D008297:Male; D008875:Middle Aged; D011020:Pneumonia, Pneumocystis / Q000175:diagnosis* / Q000209:etiology* / Q000401:mortality; D011379:Prognosis; D012372:ROC Curve; D012720:Severity of Illness Index; D014057:Tomography, X-Ray Computed
chemical_list: D015415:Biomarkers; D018836:Inflammation Mediators; D015850:Interleukin-6; D016209:Interleukin-8; D016753:Interleukin-10; D045022:Lactate Dehydrogenases