title: Flow carbonylation of sterically hindered ortho-substituted iodoarenes.
abstract: The flow synthesis of ortho-substituted carboxylic acids, using carbon monoxide gas, has been studied for a number of substrates. The optimised conditions make use of a simple catalyst system compromising of triphenylphosphine as the ligand and palladium acetate as the pre-catalyst. Carbon monoxide was introduced via a reverse "tube-in-tube" flow reactor at elevated pressures to give yields of carboxylated products that are much higher than those obtained under normal batch conditions.
authors: Department of Chemistry, Durham University, South Road, Durham, DH1 3LE, United Kingdom.
authors: Carl J
authors: CJ
authors: Mallia
authors: Syngenta CP R&D Chemistry, Jealott's Hill International Research Centre, Bracknell, Berkshire, RG42 6EY, United Kingdom.
authors: Gary C
authors: GC
authors: Walter
authors: Department of Chemistry, Durham University, South Road, Durham, DH1 3LE, United Kingdom.
authors: Ian R
authors: IR
authors: Baxendale
keywords: carbon monoxide; carbonylation of ortho-substituted substrates; flow chemistry; gases in flow; “tube-in-tube”