title: Nickel-Catalyzed Aromatic C-H Functionalization.
abstract: Catalytic C-H functionalization using transition metals has received significant interest from organic chemists because it provides a new strategy to construct carbon-carbon bonds and carbon-heteroatom bonds in highly functionalized, complex molecules without pre-functionalization. Recently, inexpensive catalysts based on transition metals such as copper, iron, cobalt, and nickel have seen more use in the laboratory. This review describes recent progress in nickel-catalyzed aromatic C-H functionalization reactions classified by reaction types and reaction partners. Furthermore, some reaction mechanisms are described and cutting-edge syntheses of natural products and pharmaceuticals using nickel-catalyzed aromatic C-H functionalization are presented.
authors: Department of Applied Chemistry, Waseda University, Tokyo, 169-8555, Japan. junyamaguchi@waseda.jp.
authors: Junichiro
authors: J
authors: Yamaguchi
authors: Department of Applied Chemistry, Waseda University, Tokyo, 169-8555, Japan.
authors: Kei
authors: K
authors: Muto
authors: Institute of Transformative Bio-Molecules (WPI-ITbM) and Graduate School of Science, Nagoya University, Chikusa, Nagoya, 464-8602, Japan. itami@chem.nagoya-u.ac.jp.|JST-ERATO, Itami Molecular Nanocarbon Project, Nagoya University, Chikusa, Nagoya, 464-8602, Japan. itami@chem.nagoya-u.ac.jp.
authors: Kenichiro
authors: K
authors: Itami
keywords: Arenes; Catalyst; C–H activation; C–H functionalization; Heteroarenes; Nickel