title: GLP-1 as a target for therapeutic intervention.
abstract: Glucagon-like peptide receptor agonists (GLP-1 RA) have multiple effects, including control of glycaemia via stimulation of insulin and suppression of glucagon secretion and reduction of adiposity by enhancing satiety, so are an attractive therapeutic option in type 2 diabetes management. Five GLP-1 RA are used currently and more are in development. The HbA1c reduction obtained varies from 1 to 2%; they reduce body weight by about 2-3kg when used to treat T2DM, while liraglutide results in greater weight loss at a higher dose and has recently been approved for the management of obesity. GLP-1 RA are usually used in combination with other glucose-lowering drugs, but dual combinations with basal insulin in a single injection have recently become available. The next decade is likely to see the development of more potent and longer lasting agents as well as hybrid molecules with dual or triple actions.
authors: Obesity and Endocrinology Clinical Research, Institute of Ageing and Chronic Disease, University of Liverpool, United Kingdom.
authors: Surya Panicker
authors: SP
authors: Rajeev
authors: Obesity and Endocrinology Clinical Research, Institute of Ageing and Chronic Disease, University of Liverpool, United Kingdom. Electronic address: J.P.H.Wilding@liverpool.ac.uk.
authors: John
authors: J
authors: Wilding
mesh_terms: D001786:Blood Glucose / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy*; D004359:Drug Therapy, Combination; D052216:Glucagon-Like Peptide 1 / Q000378:metabolism; D006801:Humans; D007004:Hypoglycemic Agents / Q000008:administration & dosage / Q000494:pharmacology*; D007328:Insulin / Q000378:metabolism; D000069450:Liraglutide / Q000008:administration & dosage / Q000494:pharmacology; D009765:Obesity / Q000188:drug therapy; D000097789:Glucagon-Like Peptide-1 Receptor Agonists
chemical_list: D001786:Blood Glucose; D007004:Hypoglycemic Agents; D007328:Insulin; D000069450:Liraglutide; D052216:Glucagon-Like Peptide 1; D000097789:Glucagon-Like Peptide-1 Receptor Agonists