title: Glycated albumin indicates peripheral diabetic neuropathy.
abstract: OBJECTIVE
  We investigated associations between serum levels of glycated albumin (GA) and glycated hemoglobin (HbA1c) and the presence of diabetic peripheral neuropathy (DPN) in patients with type 1 diabetes mellitus (T1DM).
  
  
  METHODS
  Between September 2009 and April 2015, we evaluated 314 patients with T1DM in the Endocrinology Department of Shengjing Hospital of China Medical University. We divided the patients into the DPN group (n = 72) and the non-DPN group (n = 242), on the basis of the presence of DPN.
  
  
  RESULTS
  The DPN group had significantly higher GA values than the non-DPN group. After univariate logistic regression, we selected several factors for further analysis: HbA1c, GA, duration of T1DM, body mass index, smoking, hypertension, and the presence of diabetic complications, including nephropathy, retinopathy, and cardiovascular disease. We performed a multivariate logistic regression analysis to examine the association between the presence of DPN and each of these variables. We identified GA, HbA1c, hypertension, smoking, retinopathy, and cardiovascular disease as independent variables for indicating the presence of DPN. Results of a receiver operating characteristic curve analysis revealed that the area under the curve of GA (0.771) was larger than that of HbA1c (0.629). We defined the cutoff value of GA as 23.5 % (sensitivity 0.764, specificity 0.661) and the cutoff value of HbA1c as 8.45 % (sensitivity 0.667, specificity 0.595) for predicting DPN in patients with T1DM.
  
  
  CONCLUSIONS
  GA may be a better indicative marker of DPN in patients with T1DM than HbA1c.
authors: Endocrinology Department, Shengjing Hospital of China Medical University, Shenyang, 110004, China.
authors: Nana
authors: N
authors: Wang
authors: Hospital Administration Office, Shengjing Hospital of China Medical University, Shenyang, 110004, China.
authors: Chuanji
authors: C
authors: Guo
authors: Endocrinology Department, Shengjing Hospital of China Medical University, Shenyang, 110004, China.
authors: Ping
authors: P
authors: Han
authors: Emergency Department, Shengjing Hospital of China Medical University, No. 36, Sanhao Street, Heping District, Shenyang, 110004, China. litg@sj-hospital.org.
authors: Tiegang
authors: T
authors: Li
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000032:analysis / Q000097:blood; D002318:Cardiovascular Diseases / Q000453:epidemiology; D002681:China / Q000453:epidemiology; D003922:Diabetes Mellitus, Type 1 / Q000097:blood / Q000150:complications; D003929:Diabetic Neuropathies / Q000097:blood / Q000453:epidemiology / Q000209:etiology; D005260:Female; D006442:Glycated Hemoglobin / Q000032:analysis*; D017127:Glycation End Products, Advanced; D006801:Humans; D016015:Logistic Models; D008297:Male; D012307:Risk Factors; D012709:Serum Albumin / Q000032:analysis*; D012907:Smoking / Q000453:epidemiology; D000093423:Glycated Serum Albumin
chemical_list: D015415:Biomarkers; D006442:Glycated Hemoglobin; D017127:Glycation End Products, Advanced; D012709:Serum Albumin; D000093423:Glycated Serum Albumin
keywords: Diabetic peripheral neuropathy; Glycated albumin; Hemoglobin A1c; Type 1 diabetes mellitus