title: Antioxidant and hepatoprotective activities of polysaccharides from Anoectochilus roxburghii.
abstract: The physicochemical properties (molecular weights and monosaccharide compositions), antioxidant and hepatoprotective activities of polysaccharides (ARPPs: ARPP30, ARPP60 and ARPP80) isolated from Anoectochilus roxburghii were investigated. ARPP80 exhibited relatively strong antioxidant activities in a concentration-dependent manner. In mice subjected to carbon tetrachloride-induced hepatotoxicity, ARPP80 pretreatment significantly (p<0.01) reduced the levels of aspartate and alanine amino transferases and malonyldialdehyde, prominently (p<0.01) restored the levels of superoxide dismutase, catalase, glutathione peroxidase and reduced glutathione in serum or liver homogenate. These hepatoprotective effects were comparable to those of the standard drug silymarin at the same dose (200mg/kg). The study clearly demonstrated that ARPPs, especially ARPP80, might be suitable as functional foods or hepatoprotective drugs.
authors: College of Horticulture, Fujian Agricultural and Forestry University, Fuzhou 350002, China; Fujian Key Laboratory of Physiology and Biochemistry for Subtropical Plant, Fujian Institute of Subtropical Botany, Xiamen 361006, China.
authors: Biyu
authors: B
authors: Zeng
authors: College of Horticulture, Fujian Agricultural and Forestry University, Fuzhou 350002, China; Fujian Key Laboratory of Physiology and Biochemistry for Subtropical Plant, Fujian Institute of Subtropical Botany, Xiamen 361006, China.
authors: Minghua
authors: M
authors: Su
authors: College of Horticulture, Fujian Agricultural and Forestry University, Fuzhou 350002, China. Electronic address: cqx0246@fafu.edu.cn.
authors: Qingxi
authors: Q
authors: Chen
authors: College of Horticulture, Fujian Agricultural and Forestry University, Fuzhou 350002, China; Fujian Key Laboratory of Physiology and Biochemistry for Subtropical Plant, Fujian Institute of Subtropical Botany, Xiamen 361006, China.
authors: Qiang
authors: Q
authors: Chang
authors: College of Horticulture, Fujian Agricultural and Forestry University, Fuzhou 350002, China; Fujian Key Laboratory of Physiology and Biochemistry for Subtropical Plant, Fujian Institute of Subtropical Botany, Xiamen 361006, China.
authors: Wei
authors: W
authors: Wang
authors: Fujian Key Laboratory of Physiology and Biochemistry for Subtropical Plant, Fujian Institute of Subtropical Botany, Xiamen 361006, China.
authors: Huihua
authors: H
authors: Li
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000737:chemistry / Q000627:therapeutic use*; D002251:Carbon Tetrachloride; D002374:Catalase / Q000032:analysis; D056486:Chemical and Drug Induced Liver Injury / Q000097:blood / Q000473:pathology / Q000517:prevention & control*; D005978:Glutathione / Q000032:analysis; D005979:Glutathione Peroxidase / Q000032:analysis; D008099:Liver / Q000187:drug effects* / Q000473:pathology; D008297:Male; D051379:Mice; D029595:Orchidaceae / Q000737:chemistry*; D010084:Oxidation-Reduction / Q000187:drug effects; D011134:Polysaccharides / Q000737:chemistry / Q000627:therapeutic use*; D020011:Protective Agents / Q000737:chemistry / Q000627:therapeutic use*; D013482:Superoxide Dismutase / Q000032:analysis
chemical_list: D000975:Antioxidants; D011134:Polysaccharides; D020011:Protective Agents; D002251:Carbon Tetrachloride; D002374:Catalase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D005978:Glutathione
keywords: Anoectochilus roxburghii; Antioxidant and hepatoprotective activities; Characterization; Polysaccharides