title: Effect of mesenchymal stem cells and galantamine nanoparticles in rat model of Alzheimer's disease.
abstract: The present study investigated the efficacy of bone marrow-derived mesenchymal stem cells (BM-MSCs) in combination with galantamine hydrobromide-loaded solid lipid nanoparticles (GH-SLNs) in intracerebroventricular (ICV)-isoproterenol-induced rat model of Alzheimer's disease.
  
  
  
  BM-MSCs were harvested by dissecting femur and tibia of 8-10-week-old Wistar rats. 1 × 10(6) cells were administered intravenously once in ICV-isoproterenol-induced rats followed by GH-SLNs (5 mg/kg) for 3 weeks.
  
  
  
  ICV-isoproterenol resulted in significant memory deficit. The results demonstrated rapid regain of memory in isoproterenol-induced amnesic rats, following single intravenous administration of BM-MSCs and oral administration of GH-SLNs for 21 days. The combination of BM-MSCs and GH-SLNs produced a more pronounced protective effect, therefore, could be explored for the management of Alzheimer's disease.
authors: Department of Pharmacology, Post Graduate Institute of Medical Education & Research, Chandigarh 160012, India.
authors: Shubham
authors: S
authors: Misra
authors: Pharmacology Division, University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh 160014, India.
authors: Kanwaljit
authors: K
authors: Chopra
authors: Department of Histopathology, Post Graduate Institute of Medical Education & Research, Chandigarh 160012, India.
authors: Uma Nahar
authors: UN
authors: Saikia
authors: Pharmaceutics Division, University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh 160014, India.
authors: Vivek Ranjan
authors: VR
authors: Sinha
authors: Department of Medical Parasitology, Post Graduate Institute of Medical Education & Research, Chandigarh 160012, India.
authors: Rakesh
authors: R
authors: Sehgal
authors: Department of Neurology, Post Graduate Institute of Medical Education & Research, Chandigarh 160012, India.
authors: Manish
authors: M
authors: Modi
authors: Department of Pharmacology, Post Graduate Institute of Medical Education & Research, Chandigarh 160012, India.
authors: Bikash
authors: B
authors: Medhi
mesh_terms: D000318:Adrenergic beta-Agonists / Q000633:toxicity; D000544:Alzheimer Disease / Q000139:chemically induced / Q000628:therapy*; D000818:Animals; D001522:Behavior, Animal; D002478:Cells, Cultured; D003131:Combined Modality Therapy; D005702:Galantamine / Q000008:administration & dosage*; D018836:Inflammation Mediators; D007545:Isoproterenol / Q000633:toxicity; D008297:Male; D045164:Mesenchymal Stem Cell Transplantation; D059630:Mesenchymal Stem Cells / Q000166:cytology*; D053758:Nanoparticles / Q000008:administration & dosage* / Q000737:chemistry; D010277:Parasympathomimetics / Q000008:administration & dosage*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D000318:Adrenergic beta-Agonists; D018836:Inflammation Mediators; D010277:Parasympathomimetics; D005702:Galantamine; D007545:Isoproterenol
keywords: Alzheimer's disease; galantamine; isoproterenol; mesenchymal stem cells; solid lipid nanoparticles