title: Endothelial progenitor cells and burn injury - exploring the relationship.
abstract: Burn wounds result in varying degrees of soft tissue damage that are typically graded clinically. Recently a key participant in neovascularization, the endothelial progenitor cell, has been the subject of intense cardiovascular research to explore whether it can serve as a biomarker for vascular injury. In this review, we examine the identity of the endothelial progenitor cell as well as the evidence that support its role as a key responder after burn insult. While there is conflicting evidence with regards to the delta of endothelial progenitor cell mobilization and burn severity, it is clear that they play an important role in wound healing. Systematic and controlled studies are needed to clarify this relationship, and whether this population can serve as a biomarker for burn severity.
authors: Department of Plastic Surgery, Center for Tissue Engineering, University of California, Irvine, 200S Manchester Ave, Ste 650, Orange, CA 92868 USA.
authors: Derek A
authors: DA
authors: Banyard
authors: Department of Plastic Surgery, Center for Tissue Engineering, University of California, Irvine, 200S Manchester Ave, Ste 650, Orange, CA 92868 USA.
authors: Blake O
authors: BO
authors: Adnani
authors: Department of Plastic Surgery, Center for Tissue Engineering, University of California, Irvine, 200S Manchester Ave, Ste 650, Orange, CA 92868 USA.
authors: Satenik
authors: S
authors: Melkumyan
authors: Department of Plastic Surgery, Center for Tissue Engineering, University of California, Irvine, 200S Manchester Ave, Ste 650, Orange, CA 92868 USA.
authors: Cheryl Ann
authors: CA
authors: Araniego
authors: Department of Plastic Surgery, Center for Tissue Engineering, University of California, Irvine, 200S Manchester Ave, Ste 650, Orange, CA 92868 USA.
authors: Alan D
authors: AD
authors: Widgerow
keywords: Burn biomarker; Burn depth; Circulating angiogenic cells; Endothelial progenitor cells