title: Blunted dynamics of adenosine A2A receptors is associated with increased susceptibility to Candida albicans infection in the elderly.
abstract: Opportunistic gut infections and chronic inflammation, in particular due to overgrowth of Candida albicans present in the gut microbiota, are increasingly reported in the elder population. In aged, adult and young mice, we now compared the relative intestinal over-colonization by ingested C. albicans and their translocation to other organs, focusing on the role of adenosine A2A receptors that are a main stop signal of inflammation. We report that elderly mice are more prone to over-colonization by C. albicans than adult and young mice. This fungal over-growth seems to be related with higher growth rate in intestinal lumen, independent of gut tissues invasion, but resulting in higher GI tract inflammation. We observed a particularly high colonization of the stomach, with increased rate of yeast-to-hypha transition in aged mice. We found a correlation between A2A receptor density and tissue damage due to yeast infection: comparing with young and adults, aged mice have a lower gut A2A receptor density and C. albicans infection failed to increase it. In conclusion, this study shows that aged mice have a lower ability to cope with inflammation due to C. albicans over-colonization, associated with an inability to adaptively adjust adenosine A2A receptors density.
authors: CNC-Centre for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal.|FMUC-Faculty of Medicine, University of Coimbra, Coimbra, Portugal.
authors: Lisa
authors: L
authors: Rodrigues
authors: Department of Microbiology, Cardiovascular Research & Development Unit, CINTESIS-Center for Health Technology and Services Research, Faculty of Medicine, University of Porto, Porto, Portugal.
authors: Isabel M
authors: IM
authors: Miranda
authors: Department of Physiology and Pharmacology, Federal University of Ceará, Ceará, Brazil.
authors: Geanne M
authors: GM
authors: Andrade
authors: CNC-Centre for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal.|FMUC-Faculty of Medicine, University of Coimbra, Coimbra, Portugal.
authors: Marta
authors: M
authors: Mota
authors: CNC-Centre for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal.
authors: Luísa
authors: L
authors: Cortes
authors: Department of Microbiology, Cardiovascular Research & Development Unit, CINTESIS-Center for Health Technology and Services Research, Faculty of Medicine, University of Porto, Porto, Portugal.
authors: Acácio G
authors: AG
authors: Rodrigues
authors: CNC-Centre for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal.|FMUC-Faculty of Medicine, University of Coimbra, Coimbra, Portugal.
authors: Rodrigo A
authors: RA
authors: Cunha
authors: CNC-Centre for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal.|FMUC-Faculty of Medicine, University of Coimbra, Coimbra, Portugal.
authors: Teresa
authors: T
authors: Gonçalves
mesh_terms: D000375:Aging; D000818:Animals; D002176:Candida albicans; D002177:Candidiasis / Q000235:genetics* / Q000378:metabolism; D005243:Feces; D041981:Gastrointestinal Tract / Q000382:microbiology; D007249:Inflammation; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D043705:Receptor, Adenosine A2A / Q000235:genetics*; D013270:Stomach / Q000382:microbiology
chemical_list: D043705:Receptor, Adenosine A2A
keywords: Candida albicans; Gerotarget; adenosine A2A receptors; ageing; gut; infection