title: Intra-Articular Pigmentation of Synovium: An Unusual Cause.
abstract: An unusual grayish brown discoloration of the synovium was found during a knee arthroscopy of a 72-year-old man. He also had similar pigmentation affecting the skin on the legs, arms, hands, and face. It was found he had been taking 400 mg of amiodarone hydrochloride daily for last 7 years. Amiodarone is known to cause a slate grey pigmentation of skin and cornea, but we believe this is the first report of amiodarone-induced pigmentation of the synovium. The arthroscopist should be aware of the possibility of drug-related synovial pigmentation and include this in differential diagnosis.
authors: Department of Trauma and Orthopaedics, The Alfred, Melbourne, Australia.
authors: Shobhit
authors: S
authors: Verma
authors: Department of Trauma and Orthopaedics, The Alfred, Melbourne, Australia.
authors: Steven
authors: S
authors: Hamilton
authors: Department of Trauma and Orthopaedics, The Alfred, Melbourne, Australia.
authors: Sue M
authors: SM
authors: Liew
mesh_terms: D000368:Aged; D000638:Amiodarone / Q000009:adverse effects* / Q000627:therapeutic use; D000889:Anti-Arrhythmia Agents / Q000009:adverse effects* / Q000627:therapeutic use; D001145:Arrhythmias, Cardiac / Q000150:complications / Q000188:drug therapy; D001182:Arthroscopy; D003937:Diagnosis, Differential; D006801:Humans; D007719:Knee Joint / Q000601:surgery; D008297:Male; D010859:Pigmentation Disorders / Q000139:chemically induced* / Q000175:diagnosis*; D012867:Skin / Q000473:pathology; D013583:Synovial Membrane / Q000473:pathology*
chemical_list: D000889:Anti-Arrhythmia Agents; D000638:Amiodarone
keywords: Arthroscopy; Articular; Knee; Pigmentation; Synovium