title: Risks of acute coronary syndrome in patients with osteoarthritis: a nationwide population-based cohort study.
abstract: Recent studies have reported that osteoarthritis (OA) is related to inflammation and atherosclerosis. Studies on the relationship between OA and acute coronary syndrome (ACS) are scant. We evaluated the risk of ACS in OA patients of an Asian population. This longitudinal, population-based cohort study investigated the incidence and risk of ACS in 46,042 patients with newly diagnosed OA and 46,042 controls selected randomly from the general population and frequency matched according to age, sex, and entry year (2002-2003). The follow-up period ranged from the entry date until the date of an ACS event, loss to follow-up, or the end of 2010. We employed Cox proportional hazard models to estimate the effects of OA on the risk of ACS. The OA patients showed a 15 % higher risk of ACS than did the controls after adjustment for covariates (adjusted hazard ratio [aHR] = 1.15, 95 % confidence interval [CI] = 1.08-1.23). The risk of ACS in the OA patients was the greatest in young adults (aHR = 2.0, 95 % CI = 1.44-2.78), followed by middle-aged (aHR = 1.15, 95 % CI = 1.01-1.31) and older adults (aHR = 1.11, 95 % CI = 1.03-1.20). The risk of ACS was 1.96-fold in young adults with mild to moderate OA and 3.51-fold in young adults with severe OA compared with their counterparts without OA. OA carries an increased risk of ACS, particularly in young adults with severe OA. Clinicians should employ proactive strategies for preventing ACS occurrence in these patients.
authors: Department of Internal Medicine, Taichung Hospital, Ministry of Health and Welfare, No. 199, Section 1, San-Min Road, Taichung, 40343, Taiwan. chung.w53@msa.hinet.net.|Department of Health Services Administration, China Medical University, Taichung, Taiwan. chung.w53@msa.hinet.net.|Department of Healthcare Administration, Central Taiwan University of Science and Technology, Taichung, Taiwan. chung.w53@msa.hinet.net.
authors: Wei-Sheng
authors: WS
authors: Chung
authors: Department of Management Information Systems, Central Taiwan University of Science and Technology, Taichung, Taiwan.
authors: Hsuan-Hung
authors: HH
authors: Lin
authors: Department of Internal Medicine, Taoyuan General Hospital, Ministry of Health and Welfare, Taoyuan, Taiwan.
authors: Feng-Ming
authors: FM
authors: Ho
authors: Department of Physical Medicine and Rehabilitation, Taichung Hospital, Ministry of Health and Welfare, Taichung, Taiwan.
authors: Chung-Liang
authors: CL
authors: Lai
authors: Department of Internal Medicine, Lotung Poh-Ai Hospital, Yilan, Taiwan.
authors: Chia-Lun
authors: CL
authors: Chao
mesh_terms: D054058:Acute Coronary Syndrome / Q000453:epidemiology*; D000328:Adult; D000367:Age Factors; D000368:Aged; D015897:Comorbidity; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D010003:Osteoarthritis / Q000453:epidemiology*; D012189:Retrospective Studies; D012306:Risk; D012737:Sex Factors; D013624:Taiwan / Q000453:epidemiology; D055815:Young Adult
keywords: Acute coronary syndrome (ACS); Cohort study; Inflammation; Osteoarthritis (OA)