title: High-Sensitivity C-Reactive Protein and Leptin Levels Related to Body Mass Index Changes Throughout Childhood.
abstract: OBJECTIVE
  To analyze the association between high-sensitivity C-reactive protein (hs-CRP) levels and cardiovascular risk factors in healthy school children, and to evaluate whether changes in body mass index (BMI) category throughout childhood affect hs-CRP levels.
  
  
  METHODS
  We measured serum hs-CRP levels, lipid profile, insulin levels, and leptin levels in 683 prepubertal children and 748 adolescents. A total of 272 children participated in the study in both cohorts, prepubertal (baseline; age 6-8 years) and adolescents (follow-up; age 12-16 years).
  
  
  RESULTS
  Compared with their normal weight (NW) counterparts, hs-CRP levels were significantly higher in obese and overweight (OW) adolescents and obese prepubertal children. The highest hs-CRP levels were seen in children who were OW at baseline and at follow-up, and the lowest levels in those who transitioned from OW at baseline to NW at follow-up. High-density lipoprotein cholesterol and apolipoprotein A-I levels decreased across the hs-CRP tertile in both prepubertal children and adolescents, with significant differences (P < .001) in concentrations between the highest and lowest tertiles in 6- to 8-year-old boys and girls and in 12- to 16-year-old boys. The hs-CRP levels were also significantly associated with leptin levels in both prepubertal children and adolescents, with a significant increase across hs-CRP tertiles (P < .001).
  
  
  CONCLUSIONS
  The shift from OW to NW throughout childhood is associated with a decrease in hs-CRP level to below that observed in children who maintain NW throughout childhood. Leptin levels were strongly associated with hs-CRP levels in our population independent of BMI. Our findings suggest that an obesity-related chronic inflammatory state may be reversible by improving weight status.
authors: Lipid Research Laboratory, IIS-Fundacion Jimenez Diaz, Universidad Autónoma de Madrid, Madrid, Spain.
authors: Pilar
authors: P
authors: Navarro
authors: Lipid Research Laboratory, IIS-Fundacion Jimenez Diaz, Universidad Autónoma de Madrid, Madrid, Spain.
authors: Olaya
authors: O
authors: de Dios
authors: Lipid Research Laboratory, IIS-Fundacion Jimenez Diaz, Universidad Autónoma de Madrid, Madrid, Spain; Department of Pediatrics, IIS-Fundacion Jimenez Diaz, Madrid, Spain.
authors: Teresa
authors: T
authors: Gavela-Pérez
authors: Lipid Research Laboratory, IIS-Fundacion Jimenez Diaz, Universidad Autónoma de Madrid, Madrid, Spain.
authors: Asha
authors: A
authors: Jois
authors: Lipid Research Laboratory, IIS-Fundacion Jimenez Diaz, Universidad Autónoma de Madrid, Madrid, Spain. Electronic address: cgarces@fjd.es.
authors: Carmen
authors: C
authors: Garcés
authors: Lipid Research Laboratory, IIS-Fundacion Jimenez Diaz, Universidad Autónoma de Madrid, Madrid, Spain; Department of Pediatrics, IIS-Fundacion Jimenez Diaz, Madrid, Spain.
authors: Leandro
authors: L
authors: Soriano-Guillén
mesh_terms: D000293:Adolescent; D015992:Body Mass Index; D002097:C-Reactive Protein / Q000032:analysis*; D002648:Child; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D007328:Insulin / Q000097:blood; D020738:Leptin / Q000097:blood*; D008055:Lipids / Q000097:blood; D008297:Male; D009765:Obesity / Q000097:blood*; D050177:Overweight / Q000097:blood*; D012307:Risk Factors
chemical_list: D007328:Insulin; D020738:Leptin; D008055:Lipids; D002097:C-Reactive Protein
keywords: children; hs-CRP; obesity