title: Joint effects of pregnancy, sociocultural, and environmental factors on early life gut microbiome structure and diversity.
abstract: The joint impact of pregnancy, environmental, and sociocultural exposures on early life gut microbiome is not yet well-characterized, especially in racially and socioeconomically diverse populations. Gut microbiota of 298 children from a Detroit-based birth cohort were profiled using 16S rRNA sequencing: 130 neonates (median age = 1.2 months) and 168 infants (median age = 6.6 months). Multiple factors were associated with neonatal gut microbiome composition in both single- and multi-factor models, with independent contributions of maternal race-ethnicity, breastfeeding, mode of delivery, marital status, exposure to environmental tobacco smoke, and indoor pets. These findings were consistent in the infants, and networks demonstrating the shared impact of factors on gut microbial composition also showed notable topological similarity between neonates and infants. Further, latent groups defined by these factors explained additional variation, highlighting the importance of combinatorial effects. Our findings also have implications for studies investigating the impact of the early life gut microbiota on disease.
authors: Department of Public Health Sciences, Henry Ford Health System, Detroit, MI, 48202, USA.|Center for Bioinformatics, Henry Ford Health System, Detroit, MI, 48202, USA.
authors: Albert M
authors: AM
authors: Levin
authors: Department of Public Health Sciences, Henry Ford Health System, Detroit, MI, 48202, USA.
authors: Alexandra R
authors: AR
authors: Sitarik
authors: Department of Public Health Sciences, Henry Ford Health System, Detroit, MI, 48202, USA.
authors: Suzanne L
authors: SL
authors: Havstad
authors: Division of Gastroenterology, Department of Medicine, University of California, San Francisco, CA, 94143, USA.
authors: Kei E
authors: KE
authors: Fujimura
authors: Department of Public Health Sciences, Henry Ford Health System, Detroit, MI, 48202, USA.
authors: Ganesa
authors: G
authors: Wegienka
authors: Department of Public Health Sciences, Henry Ford Health System, Detroit, MI, 48202, USA.
authors: Andrea E
authors: AE
authors: Cassidy-Bushrow
authors: Division of Allergy and Clinical Immunology, Department of Medicine, Henry Ford Health System, Detroit, MI, 48202, USA.
authors: Haejin
authors: H
authors: Kim
authors: Division of Allergy and Clinical Immunology, Department of Medicine, Henry Ford Health System, Detroit, MI, 48202, USA.
authors: Edward M
authors: EM
authors: Zoratti
authors: Department of Pathology, University of Michigan, Ann Arbor, MI, 48109, USA.
authors: Nicholas W
authors: NW
authors: Lukacs
authors: Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of California, San Francisco, CA, 94143, USA.
authors: Homer A
authors: HA
authors: Boushey
authors: Division of Allergy and Immunology, Medical College of Georgia at Augusta University, Augusta, GA, 30912, USA.
authors: Dennis R
authors: DR
authors: Ownby
authors: Division of Gastroenterology, Department of Medicine, University of California, San Francisco, CA, 94143, USA.
authors: Susan V
authors: SV
authors: Lynch
authors: Department of Public Health Sciences, Henry Ford Health System, Detroit, MI, 48202, USA.
authors: Christine C
authors: CC
authors: Johnson
mesh_terms: D000328:Adult; D000465:Algorithms; D000818:Animals; D001942:Breast Feeding; D003466:Cultural Characteristics; D004777:Environment; D005243:Feces; D005260:Female; D000069196:Gastrointestinal Microbiome; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007422:Intestines / Q000382:microbiology*; D008019:Life Style; D064307:Microbiota; D008875:Middle Aged; D009035:Mothers; D057805:Pets; D010802:Phylogeny; D011247:Pregnancy; D011248:Pregnancy Complications; D012336:RNA, Ribosomal, 16S / Q000235:genetics; D012907:Smoking / Q000009:adverse effects; D012923:Social Class; D055815:Young Adult
chemical_list: D012336:RNA, Ribosomal, 16S