title: Astragaloside IV ameliorates renal injury in db/db mice.
abstract: Diabetic nephropathy is a lethal complication of diabetes mellitus and a major type of chronic kidney disease. Dysregulation of the Akt pathway and its downstream cascades, including mTOR, NFκB, and Erk1/2, play a critical role in the development of diabetic nephropathy. Astragaloside IV is a major component of Huangqi and exerts renal protection in a mouse model of type 1 diabetes. The current study was undertaken to investigate the protective effects of diet supplementation of AS-IV on renal injury in db/db mice, a type 2 diabetic mouse model. Results showed that administration of AS-IV reduced albuminuria, ameliorated changes in the glomerular and tubular pathology, and decreased urinary NAG, NGAL, and TGF-β1 in db/db mice. AS-IV also attenuated the diabetes-related activation of Akt/mTOR, NFκB, and Erk1/2 signaling pathways without causing any detectable hepatotoxicity. Collectively, these findings showed AS-IV to be beneficial to type 2 diabetic nephropathy, which might be associated with the inhibition of Akt/mTOR, NFκB and Erk1/2 signaling pathways.
authors: Department of Nephrology, Shenzhen Affiliated Hospital, Guangzhou University of Chinese Medicine, Shenzhen, China.
authors: Huili
authors: H
authors: Sun
authors: Department of Nephrology, Shenzhen Affiliated Hospital, Guangzhou University of Chinese Medicine, Shenzhen, China.
authors: Wenjing
authors: W
authors: Wang
authors: Department of Nephrology, Shenzhen Affiliated Hospital, Guangzhou University of Chinese Medicine, Shenzhen, China.
authors: Pengxun
authors: P
authors: Han
authors: Department of Pathology, Shenzhen Affiliated Hospital, Guangzhou University of Chinese Medicine, Shenzhen, China.
authors: Mumin
authors: M
authors: Shao
authors: Department of Nephrology, Shenzhen Affiliated Hospital, Guangzhou University of Chinese Medicine, Shenzhen, China.
authors: Gaofeng
authors: G
authors: Song
authors: Department of Biological Sciences, the University of Texas at Dallas, Richardson, Texas, USA.
authors: Heng
authors: H
authors: Du
authors: Department of Nephrology, Shenzhen Affiliated Hospital, Guangzhou University of Chinese Medicine, Shenzhen, China.
authors: Tiegang
authors: T
authors: Yi
authors: Department of Nephrology, Shenzhen Affiliated Hospital, Guangzhou University of Chinese Medicine, Shenzhen, China.
authors: Shunmin
authors: S
authors: Li
mesh_terms: D000117:Acetylglucosamine / Q000378:metabolism; D000419:Albuminuria / Q000150:complications / Q000188:drug therapy / Q000473:pathology; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D001835:Body Weight / Q000187:drug effects; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000188:drug therapy* / Q000473:pathology / Q000503:physiopathology; D005919:Glomerular Filtration Rate; D006442:Glycated Hemoglobin / Q000378:metabolism; D006984:Hypertrophy; D007668:Kidney / Q000187:drug effects / Q000293:injuries* / Q000473:pathology* / Q000503:physiopathology; D000071068:Lipocalin-2 / Q000378:metabolism; D008099:Liver / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D051379:Mice; D010766:Phosphorylation / Q000187:drug effects; D012503:Saponins / Q000494:pharmacology / Q000627:therapeutic use*; D015398:Signal Transduction / Q000187:drug effects; D053773:Transforming Growth Factor beta1 / Q000378:metabolism; D014315:Triterpenes / Q000494:pharmacology / Q000627:therapeutic use*
chemical_list: D000117:Acetylglucosamine; D001786:Blood Glucose; D006442:Glycated Hemoglobin; D000071068:Lipocalin-2; D012503:Saponins; D053773:Transforming Growth Factor beta1; D014315:Triterpenes; C071332:Lcn2 protein, mouse; C052064:astragaloside A