title: Effect of Denosumab on Bone Mineral Density and Markers of Bone Turnover among Postmenopausal Women with Osteoporosis.
abstract: The aim of this study was to evaluate the effect of denosumab (Dmab) on bone mineral density (BMD) and bone turnover markers after 1 year of treatment. Additionally, the effect of Dmab in bisphosphonate-naïve patients (BP-naïve) compared to patients previously treated with bisphosphonates (BP-prior) was analyzed. This retrospective study included 425 postmenopausal women treated with Dmab for 1 year in clinical practice conditions in specialized centers from Argentina. Participants were also divided according to previous bisphosphonate treatment into BP-naïve and BP-prior. A control group of patients treated with BP not switched to Dmab matched by sex, age, and body mass index was used. Data are expressed as mean ± SEM. After 1 year of treatment with Dmab the bone formation markers total alkaline phosphatase and osteocalcin were significantly decreased (23.36% and 43.97%, resp.), as was the bone resorption marker s-CTX (69.61%). Significant increases in BMD were observed at the lumbar spine, femoral neck, and total hip without differences between BP-naïve and BP-prior. A better BMD response was found in BP-prior group compared with BP treated patients not switched to Dmab. Conclusion. Dmab treatment increased BMD and decreased bone turnover markers in the whole group, with similar response in BP-naïve and BP-prior patients. A better BMD response in BP-prior patients versus BP treated patients not switched to Dmab was observed.
authors: Centro de Endocrinología, Rosario, Argentina.
authors: A
authors: 0000-0002-0761-4385
authors: A
authors: Sánchez
authors: Laboratorio de Biología Ósea, Facultad de Ciencias Médicas, Universidad Nacional de Rosario, Rosario, Argentina.
authors: L R
authors: 0000-0001-6281-2096
authors: LR
authors: Brun
authors: Consultorios de Investigación Clínica Endocrinológica y del Metabolismo Óseo (CICEMO), Buenos Aires, Argentina.
authors: H
authors: H
authors: Salerni
authors: Consultorios de Investigación Clínica Endocrinológica y del Metabolismo Óseo (CICEMO), Buenos Aires, Argentina.
authors: P R
authors: 0000-0002-6130-2155
authors: PR
authors: Costanzo
authors: Mautalen Salud e Investigación, Buenos Aires, Argentina.
authors: D
authors: D
authors: González
authors: Mautalen Salud e Investigación, Buenos Aires, Argentina.
authors: A
authors: A
authors: Bagur
authors: Mautalen Salud e Investigación, Buenos Aires, Argentina; Laboratorio Osteoporosis y Enfermedades Metabólicas Óseas, INIGEM, UBA-CONICET, Hospital de Clínicas, Buenos Aires, Argentina.
authors: B
authors: B
authors: Oliveri
authors: Instituto de Diagnóstico e Investigaciones Metabólicas (IDIM), Cátedra de Osteología y Metabolismo Mineral, Universidad del Salvador, Buenos Aires, Argentina.
authors: M B
authors: 0000-0002-9397-1847
authors: MB
authors: Zanchetta
authors: Instituto de Diagnóstico e Investigaciones Metabólicas (IDIM), Cátedra de Osteología y Metabolismo Mineral, Universidad del Salvador, Buenos Aires, Argentina.
authors: V
authors: V
authors: Farías
authors: Consultorios Asociados de Endocrinología Dra. Laura Maffei, Buenos Aires, Argentina.
authors: L
authors: L
authors: Maffei
authors: Consultorios Asociados de Endocrinología Dra. Laura Maffei, Buenos Aires, Argentina.
authors: V
authors: 0000-0002-5351-5222
authors: V
authors: Premrou
authors: Centro de Endocrinología y Osteoporosis, La Plata, Argentina.
authors: J L
authors: JL
authors: Mansur
authors: Hospital Milstein, Buenos Aires, Argentina.
authors: M S
authors: MS
authors: Larroudé
authors: Instituto de Diagnóstico e Investigaciones Metabólicas (IDIM), Cátedra de Osteología y Metabolismo Mineral, Universidad del Salvador, Buenos Aires, Argentina.
authors: M A
authors: 0000-0003-4615-6820
authors: MA
authors: Sarli
authors: Instituto de Diagnóstico e Investigaciones Metabólicas (IDIM), Cátedra de Osteología y Metabolismo Mineral, Universidad del Salvador, Buenos Aires, Argentina.
authors: P
authors: 0000-0003-4041-8594
authors: P
authors: Rey
authors: Centro de Endocrinología y Osteopatías Médicas, Córdoba, Argentina.
authors: M R
authors: 0000-0003-3729-878X
authors: MR
authors: Ulla
authors: Hospital Durand, Buenos Aires, Argentina.
authors: M M
authors: MM
authors: Pavlove
authors: Hospital Durand, Buenos Aires, Argentina.
authors: S
authors: S
authors: Karlsbrum
authors: Centro de Reumatología, Rosario, Argentina.
authors: M L
authors: 0000-0002-6749-9921
authors: ML
authors: Brance