title: Pharmacodynamic and pharmacokinetic considerations in the treatment of critically Ill patients infected with carbapenem-resistant Enterobacteriaceae.
abstract: Carbapenem-Resistant Enterobacteriaceae (CRE) are an emerging healthcare crisis. Infections due to CRE are associated with high morbidity and mortality, especially in critically ill patients. Due to the multi-drug resistant nature of these infections only limited treatment options are available. Antimicrobials that have been described for the treatment of CRE infections include carbapenems, polymyxins, fosfomycin, tigecycline, aminoglycosides, and ceftazidime-avibactam. Given the limited treatment options it is imperative the pharmacokinetic and pharmacodynamics (PK-PD) characteristics of these agents are considered to optimize treatment regimens. This review will focus on the PK-PD challenges of the current treatment options for CRE infections.
authors: a Department of Pharmacy , Cleveland Clinic , Cleveland , OH , USA.
authors: Elizabeth A
authors: EA
authors: Neuner
authors: b Department of Pharmacy Practice, Infectious Diseases , Temple University , Philadelphia , PA , USA.
authors: Jason C
authors: JC
authors: Gallagher
mesh_terms: D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000494:pharmacology*; D000073182:Carbapenem-Resistant Enterobacteriaceae / Q000187:drug effects / Q000302:isolation & purification*; D016638:Critical Illness; D004756:Enterobacteriaceae Infections / Q000188:drug therapy* / Q000382:microbiology*; D006801:Humans
chemical_list: D000900:Anti-Bacterial Agents
keywords: carbapenem-resistant Enterobacteriaceae; pharmacodynamics; pharmacokinetics