title: Shared Biologic Pathways Between Alzheimer Disease and Major Depression: A Systematic Review of MicroRNA Expression Studies.
abstract: The clinical-epidemiological relationship between major depressive disorder (MDD) and Alzheimer disease (AD) suggests that they may share common neurobiologic abnormalities.
  
  
  
  The authors conducted a systematic review and identified microRNAs abnormally expressed in both AD and MDD. The pattern of microRNA regulation in each disorder and the genes regulated by each microRNA and the biologic processes and pathways regulated by these genes were identified.
  
  
  
  Seventy-four microRNAs were abnormally expressed in AD and 30 in MDD; 7 were common for both disorders (hsa-let-7f-5p, hsa-miR-664a-3p, hsa-miR-361-5p, hsa-let-7g-5p, hsa-let-7d-5p, hsa-miR-191-5p, hsa-miR-26b-5p). These microRNAs interact with 45 validated genes, and the main biologic pathways and processes regulated by them were proteostasis control, maintenance of genomic integrity, regulation of transcriptional activity, immune-inflammatory control, and neurotrophic support.
  
  
  
  The current results suggest that the maintenance of genomic integrity, proteostasis control, immune-inflammatory regulation, and neurotrophic support are key neurobiologic links between these conditions. A comprehensive hypothetical model for the interaction between MDD, aging, and the development of AD is provided.
authors: Graduate Program in Molecular Medicine, Federal University of Minas Gerais School of Medicine, Belo Horizonte, MG, Brazil.
authors: Ana Paula
authors: AP
authors: Mendes-Silva
authors: Graduate Program in Molecular Medicine, Federal University of Minas Gerais School of Medicine, Belo Horizonte, MG, Brazil.
authors: Kelly Silva
authors: KS
authors: Pereira
authors: Graduate Program in Molecular Medicine, Federal University of Minas Gerais School of Medicine, Belo Horizonte, MG, Brazil.
authors: Gesiane Thamire
authors: GT
authors: Tolentino-Araujo
authors: Graduate Program in Molecular Medicine, Federal University of Minas Gerais School of Medicine, Belo Horizonte, MG, Brazil.
authors: Eduardo de Souza
authors: Ede S
authors: Nicolau
authors: Graduate Program in Molecular Medicine, Federal University of Minas Gerais School of Medicine, Belo Horizonte, MG, Brazil.
authors: Camila Moreira
authors: CM
authors: Silva-Ferreira
authors: Department of Psychiatry and Behavioral Sciences, University of Texas Medical Science Center at Houston, Houston, TX.
authors: Antonio Lucio
authors: AL
authors: Teixeira
authors: Graduate Program in Molecular Medicine, Federal University of Minas Gerais School of Medicine, Belo Horizonte, MG, Brazil; Department of Psychiatry and Behavioral Sciences, University of Texas Medical Science Center at Houston, Houston, TX. Electronic address: brenosatler@gmail.com.
authors: Breno S
authors: BS
authors: Diniz
mesh_terms: D000544:Alzheimer Disease / Q000235:genetics*; D003865:Major Depressive Disorder / Q000235:genetics*; D015870:Gene Expression; D005786:Gene Expression Regulation; D042822:Genomic Instability / Q000235:genetics; D006801:Humans; D007249:Inflammation / Q000235:genetics; D035683:MicroRNAs / Q000235:genetics*; D000074702:Proteostasis / Q000235:genetics
chemical_list: D035683:MicroRNAs; C546177:MIRN191 microRNA, human; C528163:MIRN26 microRNA, human; C575475:MIRN361 microRNA, human; C000590115:MIRN664 microRNA, human; C487931:mirnlet7 microRNA, human
keywords: Alzheimer disease; biologic pathways; biomarkers; geriatric depression; major depressive disorder; microRNAs