title: Hypnotic effect of the essential oil from the leaves of Myrtus communis on mice.
abstract: BACKGROUND
  Myrtus communis has been suggested as a sleep aid in unconventional medicine. Moreover, previous studies have also indicated its sedative- and hypnotic-like activity. In this study, the hypnotic effect of M. communis was investigated.
  
  
  METHODS
  Essential oil (EO) of M. communis (600, 800, and 1,000 mg/kg) was given orally to Swiss albino mice of both sex, and the hypnotic effect was evaluated. In addition, the EO of M. communis (500, 600, 800, and 1,000 mg/kg) was administered orally to Swiss albino mice of both sex 60 minutes prior to pentobarbital injection (50 mg/kg). Latency to sleep and sleep duration were recorded. The effect of the EO on motor coordination and muscle relaxation was evaluated using chimney and traction tests, 60 and 90 minutes after administration of the respective doses of the EO, respectively.
  
  
  RESULTS
  There was no induction of hypnosis as the presence of the righting reflex was intact. However the EO prolonged pentobarbital-induced sleeping time and there was also 50% negative response on the chimney and traction test in a dose dependent manner.
  
  
  CONCLUSIONS
  The EO of M. communis did not produce a hypnotic effect, but it potentiated a hypnotic effect with significant central nervous system depressant activity.
authors: Department of Physiology.
authors: Muluken Walle
authors: MW
authors: Birhanie
authors: Department of Physiology.
authors: Bizuayehu
authors: B
authors: Walle
authors: Department of Nursing, College of Medicine and Health Sciences, Bahir Dar University, Bahir Dar, Ethiopia.
authors: Kidist
authors: K
authors: Rebba
keywords: Myrtus communis; essential oil; hypnotic; motor coordination; muscle relaxation