title: Getting IN on Viral RNA Condensation and Virion Maturation.
abstract: The retroviral enzyme integrase plays an essential role in the virus replication cycle by catalyzing the covalent insertion of newly synthesized viral DNA into the host cell chromosome early after infection. Now, Kessl et al. report a second function of integrase: binding to the viral RNA genome in virion particles late in the virus replication cycle to promote particle maturation.
authors: Virus-Cell Interaction Section, HIV Dynamics and Replication Program, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702, USA. Electronic address: efreed@nih.gov.
authors: Eric O
authors: EO
authors: Freed
mesh_terms: D002460:Cell Line; D004279:DNA, Viral / Q000378:metabolism; D015497:HIV-1 / Q000201:enzymology*; D012367:RNA, Viral / Q000235:genetics*; D014771:Virion / Q000235:genetics; D014779:Virus Replication / Q000235:genetics
chemical_list: D004279:DNA, Viral; D012367:RNA, Viral