title: Increment in vitamin D level and bone mineral accrual in children with vitamin D deficiency.
abstract: OBJECTIVE
  To compare different regimens of vitamin D with respect to its serum increment levels and bone mineral accrual in vitamin D-deficient children.
  
  
  METHODS
  Children identified as being vitamin D deficient (serum levels<20 ng/mL) were divided into 3 treatment groups by stratified block randomization (group 1, 4,000 IU/day of vitamin D3 plus 50 mg/kg/day calcium for 12 weeks; group 2, 30,000 IU/wk of vitamin D3 plus 50 mg/kg/day calcium for 12 weeks; and group 3, 300,000 IU of vitamin D3 once intramuscularly plus 50 mg/kg/day calcium). After regimen completion, each child received a maintenance dose of 400 IU/day vitamin D3 plus 50 mg/kg/day calcium. Their serum vitamin D level was measured after 3 and 12 months. Total body less head bone mineral concentration (BMC) and total body less head bone mineral density (BMD) were measured after 12 months.
  
  
  RESULTS
  The mean increment in serum vitamin D levels from baseline to 3 months was significantly higher in group 3 than in groups 1 and 2, but the levels from 3 to 12 months were almost similar among all 3 groups. There were no significant differences among the 3 groups with respect to percentage increase of BMD and BMC.
  
  
  CONCLUSIONS
  The injectable form of vitamin D was more efficacious than the oral forms in increasing the serum level to the normal range. All 3 regimens were equally effective in increasing the BMC and BMD. The 400 IU/day maintenance dose was sufficient to keep the serum level within the normal range.
authors: Department of Pediatrics, Ganesh Shankar Vidyarthi Memorial Medical College, Kanpur, India.
authors: Yashwant Kumar
authors: YK
authors: Rao
authors: Department of Community Medicine, Government Medical College, Kannauj, India.
authors: Tanu
authors: T
authors: Midha
authors: Department of Pediatrics, Ganesh Shankar Vidyarthi Memorial Medical College, Kanpur, India.
authors: Satyajeet
authors: S
authors: Singh
authors: Department of Pediatric Endocrinology, Regency Hospital, Kanpur, India.
authors: Anurag
authors: A
authors: Bajpai
authors: Department of Pharmacology, Ganesh Shankar Vidyarthi Memorial Medical College, Kanpur, India.
authors: Amita
authors: A
authors: Tilak
keywords: Bone mineral accrual; Bone mineral density; Calcium; Deficiency; Vitamin D