title: Exercise Training Reduces Liver Fat and Increases Rates of VLDL Clearance But Not VLDL Production in NAFLD.
abstract: Randomized controlled trials in nonalcoholic fatty liver disease (NAFLD) have shown that regular exercise, even without calorie restriction, reduces liver steatosis. A previous study has shown that 16 weeks of supervised exercise training in NAFLD did not affect total very low-density lipoprotein (VLDL) kinetics.
  
  
  
  The objective of the study was to determine the effect of exercise training on intrahepatocellular fat (IHCL) and the kinetics of large triglyceride (TG)-rich VLDL1and smaller denser VLDL2, which has a lower TG content.
  
  
  
  This was a 16-week randomized controlled trial.
  
  
  
  A total of 27 sedentary patients with NAFLD participated in the trial.
  
  
  
  The intervention was composed of supervised exercise with moderate-intensity aerobic exercise or conventional lifestyle advice (control).
  
  
  
  VLDL1and VLDL2-TG and apolipoprotein B (apoB) kinetics were investigated using stable isotopes before and after the intervention.
  
  
  
  In the exercise group, maximal oxygen uptake increased by 31% ± 6% (mean ± SEM) and IHCL decreased from 19.6% (14.8%, 30.0%) to 8.9% (5.4%, 17.3%) (median [interquartile range]) with no significant change in maximal oxygen uptake or IHCL in the control group (change between groups, P < .001 and P = .02, respectively). Exercise training increased VLDL1-TG and apoB fractional catabolic rates, a measure of clearance, (change between groups, P = .02 and P = .01, respectively), and VLDL1-apoB production rate (change between groups, P = .006), with no change in VLDL1-TG production rate. Plasma TG did not change in either group.
  
  
  
  An increased clearance of VLDL1may contribute to the significant decrease in liver fat after 16 weeks of exercise in NAFLD. A longer duration or higher-intensity exercise interventions may be needed to lower the plasma TG and VLDL production rate.
authors: Department of Diabetes and Metabolic Medicine (F.S.-M., M.B., N.C.J., A.M.U.), Faculty of Health and Medical Sciences, University of Surrey, Guildford GU2 7WG, United Kingdom; Metabolism and Nutrition Research Group (D.J.C., G.J.K.), Institute of Ageing and Chronic Disease, University of Liverpool, Liverpool L69 7ZX, United Kingdom; Section of Investigative Medicine, Endocrinology, and Metabolism (E.L.T., J.B.), University of Westminster, London W1B2UW United Kingdom; and Centre for Diabetes, Endocrinology, and Research (R.H., J.W.), Royal Surrey County Hospital, Guildford GU2 7XX, United Kingdom.
authors: F
authors: F
authors: Shojaee-Moradie
authors: Department of Diabetes and Metabolic Medicine (F.S.-M., M.B., N.C.J., A.M.U.), Faculty of Health and Medical Sciences, University of Surrey, Guildford GU2 7WG, United Kingdom; Metabolism and Nutrition Research Group (D.J.C., G.J.K.), Institute of Ageing and Chronic Disease, University of Liverpool, Liverpool L69 7ZX, United Kingdom; Section of Investigative Medicine, Endocrinology, and Metabolism (E.L.T., J.B.), University of Westminster, London W1B2UW United Kingdom; and Centre for Diabetes, Endocrinology, and Research (R.H., J.W.), Royal Surrey County Hospital, Guildford GU2 7XX, United Kingdom.
authors: D J
authors: DJ
authors: Cuthbertson
authors: Department of Diabetes and Metabolic Medicine (F.S.-M., M.B., N.C.J., A.M.U.), Faculty of Health and Medical Sciences, University of Surrey, Guildford GU2 7WG, United Kingdom; Metabolism and Nutrition Research Group (D.J.C., G.J.K.), Institute of Ageing and Chronic Disease, University of Liverpool, Liverpool L69 7ZX, United Kingdom; Section of Investigative Medicine, Endocrinology, and Metabolism (E.L.T., J.B.), University of Westminster, London W1B2UW United Kingdom; and Centre for Diabetes, Endocrinology, and Research (R.H., J.W.), Royal Surrey County Hospital, Guildford GU2 7XX, United Kingdom.
authors: M
authors: M
authors: Barrett
authors: Department of Diabetes and Metabolic Medicine (F.S.-M., M.B., N.C.J., A.M.U.), Faculty of Health and Medical Sciences, University of Surrey, Guildford GU2 7WG, United Kingdom; Metabolism and Nutrition Research Group (D.J.C., G.J.K.), Institute of Ageing and Chronic Disease, University of Liverpool, Liverpool L69 7ZX, United Kingdom; Section of Investigative Medicine, Endocrinology, and Metabolism (E.L.T., J.B.), University of Westminster, London W1B2UW United Kingdom; and Centre for Diabetes, Endocrinology, and Research (R.H., J.W.), Royal Surrey County Hospital, Guildford GU2 7XX, United Kingdom.
authors: N C
authors: NC
authors: Jackson
authors: Department of Diabetes and Metabolic Medicine (F.S.-M., M.B., N.C.J., A.M.U.), Faculty of Health and Medical Sciences, University of Surrey, Guildford GU2 7WG, United Kingdom; Metabolism and Nutrition Research Group (D.J.C., G.J.K.), Institute of Ageing and Chronic Disease, University of Liverpool, Liverpool L69 7ZX, United Kingdom; Section of Investigative Medicine, Endocrinology, and Metabolism (E.L.T., J.B.), University of Westminster, London W1B2UW United Kingdom; and Centre for Diabetes, Endocrinology, and Research (R.H., J.W.), Royal Surrey County Hospital, Guildford GU2 7XX, United Kingdom.
authors: R
authors: R
authors: Herring
authors: Department of Diabetes and Metabolic Medicine (F.S.-M., M.B., N.C.J., A.M.U.), Faculty of Health and Medical Sciences, University of Surrey, Guildford GU2 7WG, United Kingdom; Metabolism and Nutrition Research Group (D.J.C., G.J.K.), Institute of Ageing and Chronic Disease, University of Liverpool, Liverpool L69 7ZX, United Kingdom; Section of Investigative Medicine, Endocrinology, and Metabolism (E.L.T., J.B.), University of Westminster, London W1B2UW United Kingdom; and Centre for Diabetes, Endocrinology, and Research (R.H., J.W.), Royal Surrey County Hospital, Guildford GU2 7XX, United Kingdom.
authors: E L
authors: EL
authors: Thomas
authors: Department of Diabetes and Metabolic Medicine (F.S.-M., M.B., N.C.J., A.M.U.), Faculty of Health and Medical Sciences, University of Surrey, Guildford GU2 7WG, United Kingdom; Metabolism and Nutrition Research Group (D.J.C., G.J.K.), Institute of Ageing and Chronic Disease, University of Liverpool, Liverpool L69 7ZX, United Kingdom; Section of Investigative Medicine, Endocrinology, and Metabolism (E.L.T., J.B.), University of Westminster, London W1B2UW United Kingdom; and Centre for Diabetes, Endocrinology, and Research (R.H., J.W.), Royal Surrey County Hospital, Guildford GU2 7XX, United Kingdom.
authors: J
authors: J
authors: Bell
authors: Department of Diabetes and Metabolic Medicine (F.S.-M., M.B., N.C.J., A.M.U.), Faculty of Health and Medical Sciences, University of Surrey, Guildford GU2 7WG, United Kingdom; Metabolism and Nutrition Research Group (D.J.C., G.J.K.), Institute of Ageing and Chronic Disease, University of Liverpool, Liverpool L69 7ZX, United Kingdom; Section of Investigative Medicine, Endocrinology, and Metabolism (E.L.T., J.B.), University of Westminster, London W1B2UW United Kingdom; and Centre for Diabetes, Endocrinology, and Research (R.H., J.W.), Royal Surrey County Hospital, Guildford GU2 7XX, United Kingdom.
authors: G J
authors: GJ
authors: Kemp
authors: Department of Diabetes and Metabolic Medicine (F.S.-M., M.B., N.C.J., A.M.U.), Faculty of Health and Medical Sciences, University of Surrey, Guildford GU2 7WG, United Kingdom; Metabolism and Nutrition Research Group (D.J.C., G.J.K.), Institute of Ageing and Chronic Disease, University of Liverpool, Liverpool L69 7ZX, United Kingdom; Section of Investigative Medicine, Endocrinology, and Metabolism (E.L.T., J.B.), University of Westminster, London W1B2UW United Kingdom; and Centre for Diabetes, Endocrinology, and Research (R.H., J.W.), Royal Surrey County Hospital, Guildford GU2 7XX, United Kingdom.
authors: J
authors: J
authors: Wright
authors: Department of Diabetes and Metabolic Medicine (F.S.-M., M.B., N.C.J., A.M.U.), Faculty of Health and Medical Sciences, University of Surrey, Guildford GU2 7WG, United Kingdom; Metabolism and Nutrition Research Group (D.J.C., G.J.K.), Institute of Ageing and Chronic Disease, University of Liverpool, Liverpool L69 7ZX, United Kingdom; Section of Investigative Medicine, Endocrinology, and Metabolism (E.L.T., J.B.), University of Westminster, London W1B2UW United Kingdom; and Centre for Diabetes, Endocrinology, and Research (R.H., J.W.), Royal Surrey County Hospital, Guildford GU2 7XX, United Kingdom.
authors: A M
authors: AM
authors: Umpleby
mesh_terms: D050154:Adiposity; D001055:Apolipoproteins B / Q000097:blood / Q000378:metabolism*; D005081:Exercise Therapy / Q000379:methods*; D006801:Humans; D007700:Kinetics; D008079:Lipoproteins, VLDL / Q000097:blood / Q000378:metabolism*; D008099:Liver / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D065626:Non-alcoholic Fatty Liver Disease / Q000378:metabolism* / Q000628:therapy*; D017063:Outcome Assessment, Health Care; D057185:Sedentary Behavior; D014280:Triglycerides / Q000097:blood / Q000378:metabolism
chemical_list: D001055:Apolipoproteins B; D008079:Lipoproteins, VLDL; D014280:Triglycerides; C030106:very low density lipoprotein triglyceride