title: The Esophagiome: concept, status, and future perspectives.
abstract: The term "Esophagiome" is meant to imply a holistic, multiscale treatment of esophageal function from cellular and muscle physiology to the mechanical responses that transport and mix fluid contents. The development and application of multiscale mathematical models of esophageal function are central to the Esophagiome concept. These model elements underlie the development of a "virtual esophagus" modeling framework to characterize and analyze function and disease by quantitatively contrasting normal and pathophysiological function. Functional models incorporate anatomical details with sensory-motor properties and functional responses, especially related to biomechanical functions, such as bolus transport and gastrointestinal fluid mixing. This brief review provides insight into Esophagiome research. Future advanced models can provide predictive evaluations of the therapeutic consequences of surgical and endoscopic treatments and will aim to facilitate clinical diagnostics and treatment.
authors: GIOME, College of Bioengineering, Chongqing University, China. hag@giome.org.|GIOME, Department of Surgery, Prince of Wales Hospital, College of Medicine, Chinese University of Hong Kong, Hong Kong SAR. hag@giome.org.
authors: Hans
authors: H
authors: Gregersen
authors: GIOME Academy, Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.
authors: Donghua
authors: D
authors: Liao
authors: Aerospace Engineering Sciences, University of Colorado, Boulder, Colorado.
authors: James G
authors: JG
authors: Brasseur
mesh_terms: D001696:Biomechanical Phenomena / Q000502:physiology; D004943:Esophagogastric Junction / Q000502:physiology; D004947:Esophagus / Q000502:physiology*; D005544:Forecasting; D006801:Humans; D008365:Manometry / Q000379:methods / Q000639:trends; D009119:Muscle Contraction / Q000502:physiology*; D066230:Patient-Specific Modeling / Q000639:trends*
keywords: Esophagiome; GIOME; biomechanics; esophagogastric junction; esophagus; gastrointestinal; modeling; neurophysiology; peristalsis