title: Effects of 8-Week Hatha Yoga Training on Metabolic and Inflammatory Markers in Healthy, Female Chinese Subjects: A Randomized Clinical Trial.
abstract: We aimed to determine the effects of an 8 wk Hatha yoga training on blood glucose, insulin, lipid profiles, endothelial microparticles (EMPs), and inflammatory status in healthy, lean, and female Chinese subjects. A total of 30 healthy, female Chinese subjects were recruited and randomized into control or yoga practice group. The yoga practice included 8 wks of yoga practice (2 times/wk) for a total of 16 times. Fasting blood samples were collected before and after yoga training. Plasma was isolated for the measurement of lipid profiles, glucose, insulin, EMPs, and inflammatory cytokines. Whole blood was cultured ex vivo and stimulated with lipopolysaccharide (LPS) and Pam3Cys-SK4. Peripheral blood mononuclear cells (PBMCs) were isolated for the measurement of TLR2 and TLR4 protein expression. Yoga practice significantly reduced plasma cholesterol, LDL-cholesterol, insulin levels, and CD31+/CD42b- EMPs. Cultured whole blood from the yoga group has reduced proinflammatory cytokines secretion both at unstimulated condition and when stimulated with Pam3Cys-SK4; this might be associated with reduced TLR2 protein expression in PBMCs after yoga training. Hatha yoga practice in healthy Chinese female subjects could improve hallmarks related to MetS; thus it can be considered as an ancillary intervention in the primary MetS prevention for the healthy population. This trial is registered with ChiCTR-IOR-14005747.
authors: Department of Nutrition and Food Hygiene, School of Public Health, Soochow University, 199 Renai Road, Suzhou 215123, China.
authors: Neng
authors: N
authors: Chen
authors: Department of Breast Surgery, Zhejiang Cancer Hospital, Hangzhou, Zhejiang 310022, China.
authors: Xianghou
authors: X
authors: Xia
authors: Department of Nutrition and Food Hygiene, School of Public Health, Soochow University, 199 Renai Road, Suzhou 215123, China.
authors: Liqiang
authors: 0000-0002-5231-2562
authors: L
authors: Qin
authors: School of Physical Education and Sports Science, Soochow University, Suzhou 215006, China.
authors: Li
authors: 0000-0002-0536-0481
authors: L
authors: Luo
authors: Department of Nutrition and Food Hygiene, School of Public Health, Soochow University, 199 Renai Road, Suzhou 215123, China.
authors: Shufen
authors: S
authors: Han
authors: Laboratory Animal Center, Soochow University, 199 Renai Road, Suzhou 215123, China.
authors: Guiping
authors: G
authors: Wang
authors: Department of Nutrition and Food Hygiene, School of Public Health, Soochow University, 199 Renai Road, Suzhou 215123, China.
authors: Ru
authors: R
authors: Zhang
authors: Department of Nutrition and Food Hygiene, School of Public Health, Soochow University, 199 Renai Road, Suzhou 215123, China; Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Disease, Soochow University, 199 Renai Road, Suzhou 215123, China.
authors: Zhongxiao
authors: 0000-0002-6297-5933
authors: Z
authors: Wan
mesh_terms: D000293:Adolescent; D000328:Adult; D008078:Cholesterol, LDL / Q000097:blood*; D016207:Cytokines / Q000097:blood*; D005260:Female; D006801:Humans; D018836:Inflammation Mediators / Q000097:blood*; D007328:Insulin / Q000097:blood*; D007963:Leukocytes, Mononuclear / Q000378:metabolism*; D051195:Toll-Like Receptor 2 / Q000097:blood*; D051197:Toll-Like Receptor 4 / Q000097:blood*; D015013:Yoga
chemical_list: D008078:Cholesterol, LDL; D016207:Cytokines; D018836:Inflammation Mediators; D007328:Insulin; C495342:TLR2 protein, human; C495345:TLR4 protein, human; D051195:Toll-Like Receptor 2; D051197:Toll-Like Receptor 4