title: What Can hiPSC-Cardiomyocytes Teach Us about Modeling Complex Human Disease Phenotypes?
abstract: Using induced pluripotent stem cell-derived cardiomyocytes to predict patient-specific responses to drug treatments requires that they maintain inter-individual variability for RNA expression and recapitulate phenotypic responses in vitro. In this issue of Cell Stem Cell, Matsa et al. (2016) show that expression differences between hiPSC-cardiomyocytes provide a personalized drug testing platform to evaluate potential efficacy and cardiotoxicity.
authors: Section of Genomic Pediatrics, Department of Pediatrics, Medicine and Physiology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA. Electronic address: ubroeckel@mcw.edu.
authors: Ulrich
authors: U
authors: Broeckel
mesh_terms: D006801:Humans; D057026:Induced Pluripotent Stem Cells; D032383:Myocytes, Cardiac