title: Selenium Status in Patients with Turner Syndrome: a Biochemical Assessment Related with Body Composition.
abstract: Studies about selenium status in patients with Turner syndrome (TS) are non-existent in the literature. The aim of this study was to evaluate selenium status in patients with TS, while considering the different ages of the studied population and the relation with body composition. In total, 33 patients with TS were evaluated and grouped according to their developmental stages (children, adolescents, and adults). Selenium concentrations in their plasma, erythrocytes, urine, and nails were determined by using hydride generation atomic absorption spectrometry and erythrocyte glutathione peroxidase activity were measured by using Randox commercial kits. Additionally, height, weight, body fat percentage, waist circumference, and waist-height ratio were measured to characterize the patients. No differences in the selenium concentrations in the plasma, erythrocyte, urine, and nails or in the glutathione peroxidase activity were observed among the age groups (p > 0.05). The evaluated selenium levels were less than the established normal ones. The patients with larger waist circumference, body fat percentage, body mass index, and waist-height ratio showed lower glutathione peroxidase enzyme activity (p = 0.023). The present study shows that most patients with TS are deficient in selenium and that those with a greater accumulation of body fat have a lower GPx activity.
authors: Department of Food and Experimental Nutrition, Faculty of Pharmaceutical Sciences, University of São Paulo, Av. Professor Lineu Prestes, n°580, Cidade Universitária, São Paulo, SP, 05508-900, Brazil. lvianapires@gmail.com.
authors: Liliane Viana
authors: LV
authors: Pires
authors: Division of Pediatric Endocrinology, Department of Pediatrics, Federal University of São Paulo, São Paulo, Brazil.
authors: Adriana Aparecida
authors: AA
authors: Siviero-Miachon
authors: Division of Pediatric Endocrinology, Department of Pediatrics, Federal University of São Paulo, São Paulo, Brazil.
authors: Angela Maria
authors: AM
authors: Spinola-Castro
authors: Department of Food and Experimental Nutrition, Faculty of Pharmaceutical Sciences, University of São Paulo, Av. Professor Lineu Prestes, n°580, Cidade Universitária, São Paulo, SP, 05508-900, Brazil.
authors: José Alexandre Coelho
authors: JA
authors: Pimentel
authors: Department of Food and Experimental Nutrition, Faculty of Pharmaceutical Sciences, University of São Paulo, Av. Professor Lineu Prestes, n°580, Cidade Universitária, São Paulo, SP, 05508-900, Brazil.
authors: Luciana Sigueta
authors: LS
authors: Nishimura
authors: Department of Nutrition, State University of Ceara, Ceara, Brazil.
authors: Carla Soraya Costa
authors: CS
authors: Maia
authors: Department of Food and Experimental Nutrition, Faculty of Pharmaceutical Sciences, University of São Paulo, Av. Professor Lineu Prestes, n°580, Cidade Universitária, São Paulo, SP, 05508-900, Brazil.
authors: Silvia Maria Franciscato
authors: SM
authors: Cozzolino
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D006801:Humans; D009262:Nails / Q000737:chemistry; D012643:Selenium / Q000097:blood* / Q000652:urine*; D014424:Turner Syndrome / Q000097:blood* / Q000652:urine*; D055815:Young Adult
chemical_list: D012643:Selenium
keywords: Fat body; Glutathione peroxidase; Nutritional status; Selenium; Turner syndrome