title: Comparison of Cerebral Blood Volume and Plasma Volume in Untreated Intracranial Tumors.
abstract: OBJECTIVE
  Plasma volume and blood volume are imaging-derived parameters that are often used to evaluation intracranial tumors. Physiologically, these parameters are directly related, but their two different methods of measurements, T1-dynamic contrast enhanced (DCE)- and T2-dynamic susceptibility contrast (DSC)-MR utilize different model assumptions and approaches. This poses the question of whether the interchangeable use of T1-DCE-MRI derived fractionated plasma volume (vp) and relative cerebral blood volume (rCBV) assessed using DSC-MRI, particularly in glioblastoma, is reliable, and if this relationship can be generalized to other types of brain tumors. Our goal was to examine the hypothetical correlation between these parameters in three most common intracranial tumor types.
  
  
  METHODS
  Twenty-four newly diagnosed, treatment naïve brain tumor patients, who had undergone DCE- and DSC-MRI, were classified in three histologically proven groups: glioblastoma (n = 7), meningioma (n = 9), and intraparenchymal metastases (n = 8). The rCBV was obtained from DSC after normalization with the normal-appearing anatomically symmetrical contralateral white matter. Correlations between these parameters were evaluated using Pearson (r), Spearman's (ρ) and Kendall's tau-b (τB) rank correlation coefficient.
  
  
  RESULTS
  The Pearson, Spearman and Kendall's correlation between vp with rCBV were r = 0.193, ρ = 0.253 and τB = 0.33 (p-Pearson = 0.326, p-Spearman = 0.814 and p-Kendall = 0.823) in glioblastoma, r = -0.007, ρ = 0.051 and τB = 0.135 (p-Pearson = 0.970, p-Spearman = 0.765 and p-Kendall = 0.358) in meningiomas, and r = 0.289, ρ = 0.228 and τB = 0.239 (p-Pearson = 0.109, p-Spearman = 0.210 and p-Kendall = 0.095) in metastasis.
  
  
  CONCLUSIONS
  Results indicate that no correlation exists between vp with rCBV in glioblastomas, meningiomas and intraparenchymal metastatic lesions. Consequently, these parameters, as calculated in this study, should not be used interchangeably in either research or clinical practice.
authors: Department of Biomedical Engineering, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.
authors: Soha
authors: http://orcid.org/0000-0002-8425-8281
authors: S
authors: Bazyar
authors: Centro Hospitalar de Lisboa Central, Lisboa, Portugal.
authors: Joana
authors: J
authors: Ramalho
authors: Mallinckrodt Institute of Radiology, Washington University in St. Louis, St. Louis, Missouri, United States of America.
authors: Cihat
authors: C
authors: Eldeniz
authors: Mallinckrodt Institute of Radiology, Washington University in St. Louis, St. Louis, Missouri, United States of America.|Center for Clinical Imaging Research, Washington University in St. Louis, St. Louis, Missouri, United States of America.
authors: Hongyu
authors: H
authors: An
authors: Department of Biomedical Engineering, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.|Department of Radiology, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.|Biomedical Research Imaging Center, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.|Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.
authors: Yueh Z
authors: YZ
authors: Lee
mesh_terms: D000328:Adult; D000368:Aged; D001932:Brain Neoplasms / Q000097:blood / Q000145:classification / Q000503:physiopathology*; D000071937:Cerebral Blood Volume; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010953:Plasma Volume