title: Linear models of coregionalization for multivariate lattice data: Order-dependent and order-free cMCARs.
abstract: This paper concerns with multivariate conditional autoregressive models defined by linear combination of independent or correlated underlying spatial processes. Known as linear models of coregionalization, the method offers a systematic and unified approach for formulating multivariate extensions to a broad range of univariate conditional autoregressive models. The resulting multivariate spatial models represent classes of coregionalized multivariate conditional autoregressive models that enable flexible modelling of multivariate spatial interactions, yielding coregionalization models with symmetric or asymmetric cross-covariances of different spatial variation and smoothness. In the context of multivariate disease mapping, for example, they facilitate borrowing strength both over space and cross variables, allowing for more flexible multivariate spatial smoothing. Specifically, we present a broadened coregionalization framework to include order-dependent, order-free, and order-robust multivariate models; a new class of order-free coregionalized multivariate conditional autoregressives is introduced. We tackle computational challenges and present solutions that are integral for Bayesian analysis of these models. We also discuss two ways of computing deviance information criterion for comparison among competing hierarchical models with or without unidentifiable prior parameters. The models and related methodology are developed in the broad context of modelling multivariate data on spatial lattice and illustrated in the context of multivariate disease mapping. The coregionalization framework and related methods also present a general approach for building spatially structured cross-covariance functions for multivariate geostatistics.
authors: Division of Epidemiology and Biostatistics, School of Population and Public Health, University of British Columbia, Vancouver, Canada ying.macnab@ubc.ca.
authors: Ying C
authors: YC
authors: MacNab
mesh_terms: D001499:Bayes Theorem; D006801:Humans; D016014:Linear Models; D008910:Minnesota / Q000453:epidemiology; D015999:Multivariate Analysis; D009369:Neoplasms / Q000453:epidemiology; D035583:Rare Diseases / Q000453:epidemiology
keywords: Cross-covariance; cross-component local interactions; deviance information criterion; identifiability; multivariate Gaussian Markov random fields; multivariate conditional autoregressive model; multivariate disease mapping