title: National Institutes of Health Hematopoietic Cell Transplantation Late Effects Initiative: The Cardiovascular Disease and Associated Risk Factors Working Group Report.
abstract: A number of studies have shown that autologous and allogeneic hematopoietic cell transplantation (HCT) contribute to an increased incidence of cardiovascular disease (CVD) and worsening of cardiovascular risk factors that could contribute to further CVD over time. These observations, combined with a notable increase in the number of survivors after HCT in recent years, highlight the need for studies aimed at modifying risk or preventing these outcomes by changing specific approaches and/or post-HCT interventions. To address these issues, the National Heart, Lung and Blood Institute and National Cancer Institute co-sponsored an international initiative on late effects after HCT. This report summarizes the major gaps in knowledge along with detailed recommendations regarding study priorities from the Cardiovascular Disease and Associated Risk Factors Committee, a multidisciplinary panel of international experts. The committee calls for specific studies aimed at understanding and preventing arterial disease and cardiac dysfunction (heart failure, valvular disease, and arrhythmias), as well as decreasing cardiovascular risk factors (hypertension, hyperglycemia, dyslipidemia, and sarcopenic obesity) after HCT.
authors: Department of Population Sciences, City of Hope, Duarte, California. Electronic address: sarmenian@coh.org.
authors: Saro H
authors: SH
authors: Armenian
authors: Pediatric Medicine Department, St. Jude Children's Research Hospital, Memphis, Tennessee.
authors: Wassim
authors: W
authors: Chemaitilly
authors: Cardiovascular and Pulmonary Branch, National Heart, Lung, and Blood Institute, Bethesda, Maryland.
authors: Marcus
authors: M
authors: Chen
authors: Clinical Research and Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington.
authors: Eric J
authors: EJ
authors: Chow
authors: Pediatric Stem Cell Transplant Center, Dana Farber Cancer Institute, Boston, Massachusetts.
authors: Christine N
authors: CN
authors: Duncan
authors: Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.
authors: Lee W
authors: LW
authors: Jones
authors: Children's Center for Cancer and Blood Diseases, Children's Hospital Los Angeles, Los Angeles, California.
authors: Michael A
authors: MA
authors: Pulsipher
authors: Cardiovascular and Pulmonary Branch, National Heart, Lung, and Blood Institute, Bethesda, Maryland.
authors: Alan T
authors: AT
authors: Remaley
authors: Department of Hematology, University Hospital of Bern, Bern, Switzerland.
authors: Alicia
authors: A
authors: Rovo
authors: Department of Medicine, Imperial College London, London, United Kingdom.
authors: Nina
authors: N
authors: Salooja
authors: Hematopoietic Transplantation Section, National Heart, Lung, and Blood Institute, Bethesda, Maryland.
authors: Minoo
authors: M
authors: Battiwalla
mesh_terms: D000328:Adult; D064591:Allografts; D002318:Cardiovascular Diseases / Q000453:epidemiology* / Q000209:etiology / Q000628:therapy; D002648:Child; D050171:Dyslipidemias / Q000453:epidemiology / Q000209:etiology / Q000628:therapy; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects*; D006801:Humans; D006943:Hyperglycemia / Q000453:epidemiology / Q000209:etiology / Q000628:therapy; D009765:Obesity / Q000453:epidemiology / Q000209:etiology / Q000628:therapy; D012106:Research; D012189:Retrospective Studies; D012307:Risk Factors; D055948:Sarcopenia / Q000453:epidemiology / Q000209:etiology / Q000628:therapy; D017741:Survivors / Q000706:statistics & numerical data; D019172:Transplantation Conditioning / Q000009:adverse effects
keywords: Cardiovascular disease; Cardiovascular risk factors; Chronic disease; Hematopoietic cell transplantation; Late effects; National Institutes of Health consensus; Survivorship