title: [Giant Prostate Carcinoma : A Case Report and Long-Term Outcomes in Japanese Patients].
abstract: A 79-year-old male was referred to the Department of Gastroenterology in our hospital due to a large palpable abdominal mass, with the suspicion of a gastrointestinal stromal tumor. An abdominal computed tomographic (CT) scan revealed a huge mass of 270×208×144 mm which occupied the entire pelvic cavity. Since the specimens obtained by an endoscopic ultrasound-guided fine-needle aspiration via lower intestinal tract revealed a Gleason score 4＋4 prostate adenocarcinoma, he was then referred to our department. Prostate specific antigen (PSA) was elevated to 3,087 ng/ml, and positron emission tomography-CT revealed right obturator lymph node metastasis and bone metastasis of the left 5th rib. Degarelix was administered as an androgen deprivation therapy, and the PSA level had decreased to 62.4 ng/ml one month later. At the last follow-up, the PSA level was 0.67 ng/ml and the tumorsize had decreased to 88×83×110 mm. Next, we conducted a follow-up survey by mail of 20 reported Japanese cases of a giant prostate carcinoma, and data on 17 cases were available for analysis. In the total of 18 cases, including the present case, with a median follow-up time of 26 months, the 2-year overall survival rate was 85.7% for patients without metastasis, and 65.6% forthose with metastasis.
authors: The Department of Renal and Genitourinary Surgery, Hokkaido University Graduate School of Medicine.
authors: Jun
authors: J
authors: Furumido
authors: The Department of Renal and Genitourinary Surgery, Hokkaido University Graduate School of Medicine.
authors: Takashige
authors: T
authors: Abe
authors: The Department of Renal and Genitourinary Surgery, Hokkaido University Graduate School of Medicine.
authors: Hiroshi
authors: H
authors: Kikuchi
authors: The Department of Renal and Genitourinary Surgery, Hokkaido University Graduate School of Medicine.
authors: Naoto
authors: N
authors: Miyajima
authors: The Department of Renal and Genitourinary Surgery, Hokkaido University Graduate School of Medicine.
authors: Kunihiko
authors: K
authors: Tsuchiya
authors: The Department of Renal and Genitourinary Surgery, Hokkaido University Graduate School of Medicine.
authors: Satoru
authors: S
authors: Maruyama
authors: The Department of Renal and Genitourinary Surgery, Hokkaido University Graduate School of Medicine.
authors: Nobuo
authors: N
authors: Shinohara
mesh_terms: D000230:Adenocarcinoma / Q000175:diagnosis / Q000188:drug therapy* / Q000401:mortality / Q000473:pathology; D000368:Aged; D000726:Androgen Antagonists / Q000627:therapeutic use; D044466:Asian People; D014408:Biomarkers, Tumor / Q000097:blood; D007987:Gonadotropin-Releasing Hormone / Q000037:antagonists & inhibitors; D006801:Humans; D007610:Kallikreins / Q000097:blood; D008297:Male; D009842:Oligopeptides / Q000008:administration & dosage*; D000072078:Positron Emission Tomography Computed Tomography; D011379:Prognosis; D017430:Prostate-Specific Antigen / Q000097:blood; D011471:Prostatic Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000401:mortality / Q000473:pathology; D015996:Survival Rate; D013997:Time Factors; D014057:Tomography, X-Ray Computed
chemical_list: D000726:Androgen Antagonists; D014408:Biomarkers, Tumor; D009842:Oligopeptides; C431566:acetyl-2-naphthylalanyl-3-chlorophenylalanyl-1-oxohexadecyl-seryl-4-aminophenylalanyl(hydroorotyl)-4-aminophenylalanyl(carbamoyl)-leucyl-ILys-prolyl-alaninamide; D007987:Gonadotropin-Releasing Hormone; C549870:KLK3 protein, human; D007610:Kallikreins; D017430:Prostate-Specific Antigen