title: Towards potential nanoparticle contrast agents: Synthesis of new functionalized PEG bisphosphonates.
abstract: The use of nanotechnologies for biomedical applications took a real development during these last years. To allow an effective targeting for biomedical imaging applications, the adsorption of plasmatic proteins on the surface of nanoparticles must be prevented to reduce the hepatic capture and increase the plasmatic time life. In biologic media, metal oxide nanoparticles are not stable and must be coated by biocompatible organic ligands. The use of phosphonate ligands to modify the nanoparticle surface drew a lot of attention in the last years for the design of highly functional hybrid materials. Here, we report a methodology to synthesize bisphosphonates having functionalized PEG side chains with different lengths. The key step is a procedure developed in our laboratory to introduce the bisphosphonate from acyl chloride and tris(trimethylsilyl)phosphite in one step.
authors: Université Paris 13, Sorbonne Paris Cité, Laboratoire de Chimie, Structure, Propriétés de Biomatériaux et d'Agents Thérapeutiques (CSPBAT), CNRS UMR 7244, F-93017 Bobigny, France.
authors: Souad
authors: S
authors: Kachbi-Khelfallah
authors: Université Paris 13, Sorbonne Paris Cité, Laboratoire de Chimie, Structure, Propriétés de Biomatériaux et d'Agents Thérapeutiques (CSPBAT), CNRS UMR 7244, F-93017 Bobigny, France.
authors: Maelle
authors: M
authors: Monteil
authors: Université Paris 13, Sorbonne Paris Cité, Laboratoire de Chimie, Structure, Propriétés de Biomatériaux et d'Agents Thérapeutiques (CSPBAT), CNRS UMR 7244, F-93017 Bobigny, France.
authors: Margery
authors: M
authors: Cortes-Clerget
authors: Université Paris 13, Sorbonne Paris Cité, Laboratoire de Chimie, Structure, Propriétés de Biomatériaux et d'Agents Thérapeutiques (CSPBAT), CNRS UMR 7244, F-93017 Bobigny, France.
authors: Evelyne
authors: E
authors: Migianu-Griffoni
authors: ICG Montpellier-UMR 5253, Equipe AM2N, ENSCM, 8, Rue de l'Ecole Normale, F-34296 Montpellier Cedex 5, France.
authors: Jean-Luc
authors: JL
authors: Pirat
authors: Université Paris 13, Sorbonne Paris Cité, Laboratoire de Chimie, Structure, Propriétés de Biomatériaux et d'Agents Thérapeutiques (CSPBAT), CNRS UMR 7244, F-93017 Bobigny, France.
authors: Olivier
authors: O
authors: Gager
authors: Université Paris 13, Sorbonne Paris Cité, Laboratoire de Chimie, Structure, Propriétés de Biomatériaux et d'Agents Thérapeutiques (CSPBAT), CNRS UMR 7244, F-93017 Bobigny, France.
authors: Julia
authors: J
authors: Deschamp
authors: Université Paris 13, Sorbonne Paris Cité, Laboratoire de Chimie, Structure, Propriétés de Biomatériaux et d'Agents Thérapeutiques (CSPBAT), CNRS UMR 7244, F-93017 Bobigny, France.
authors: Marc
authors: M
authors: Lecouvey
keywords: Fe2O3 nanoparticle; bisphosphonate; polyethylene glycol derivatives; surface ligand synthesis