title: Regional temperature and quantitative cerebral blood flow responses to cortical spreading depolarization in the rat.
abstract: Regional temperature and quantitative regional cerebral blood flow responses to cortical spreading depolarization in the rat were continuously monitored in the same tissue using a microfabricated thermal diffusion sensor that recalibrates and measures in 5-s cycles. The regional cerebral blood flow response had four phases, including early hyperemia (peak: 226% of baseline; duration: 113.1 ± 14.4 s) and late oligemia (minimum: 57%, duration: 28.4 ± 3.7 min). Temperature rose with the start of the regional cerebral blood flow response to a peak increase of 0.28 ± 0.06℃ and returned to baseline near the start of oligemia. This technology may be useful for multimodal monitoring in both the laboratory and clinic.
authors: 1 Cushing Neuromonitoring Laboratory, Feinstein Institute for Medical Research, Manhasset, NY, USA.|2 Department of Neurosurgery, Hofstra Northwell School of Medicine, Hempstead, NY, USA.
authors: Chunyan
authors: C
authors: Li
authors: 2 Department of Neurosurgery, Hofstra Northwell School of Medicine, Hempstead, NY, USA.
authors: Raj K
authors: RK
authors: Narayan
authors: 3 Center for Translational Research, Feinstein Institute for Medical Research, Manhasset, NY, USA.
authors: Ping
authors: P
authors: Wang
authors: 4 Department of Neurosurgery, University of Cincinnati (UC) College of Medicine, UC Neuroscience Institute, and Mayfield Clinic, Cincinnati, OH, USA.
authors: Jed A
authors: JA
authors: Hartings
mesh_terms: D000818:Animals; D001831:Body Temperature / Q000502:physiology*; D002560:Cerebrovascular Circulation / Q000502:physiology*; D013181:Cortical Spreading Depression / Q000502:physiology*; D000069280:Electrocorticography; D008297:Male; D017207:Rats, Sprague-Dawley; D013817:Thermography
keywords: Spreading depression; cerebral blood flow; energy metabolism; neurocritical care; neurovascular coupling