title: Layer-by-Layer Coating of Solid Drug Cores: A Versatile Method to Improve Stability, Control Release and Tune Surface Properties.
abstract: Layer-by-layer coating is a simple and versatile technique based on the sequential deposition of molecular species on planar surfaces or colloidal templates. Its relevance in drug delivery primarily emerges from its versatility to control the release rate of the cargo encapsulated within the colloidal core. The focus of this review is the layer-by-layer encapsulation of colloidal particles purely composed of drug, including the core fabrication step, coating materials and techniques, multilayer shell permeability control, and reported in vitro and in vivo outcomes.
authors: Institute of Pharmaceutical Sciences, Department of Chemistry and Applied Biosciences, Swiss Federal Institute of Technology Zurich (ETHZ), Vladimir-Prelog Weg 1-5/10, 8093, Zurich, Switzerland.
authors: Anna
authors: A
authors: Polomska
authors: Institute of Pharmaceutical Sciences, Department of Chemistry and Applied Biosciences, Swiss Federal Institute of Technology Zurich (ETHZ), Vladimir-Prelog Weg 1-5/10, 8093, Zurich, Switzerland.
authors: Jean-Christophe
authors: JC
authors: Leroux
authors: Institute of Pharmaceutical Sciences, Department of Chemistry and Applied Biosciences, Swiss Federal Institute of Technology Zurich (ETHZ), Vladimir-Prelog Weg 1-5/10, 8093, Zurich, Switzerland.
authors: Davide
authors: D
authors: Brambilla
mesh_terms: D000818:Animals; D020099:Coated Materials, Biocompatible / Q000737:chemistry*; D016503:Drug Delivery Systems / Q000379:methods*; D065546:Drug Liberation; D004355:Drug Stability; D006801:Humans; D057927:Hydrophobic and Hydrophilic Interactions; D013499:Surface Properties
chemical_list: D020099:Coated Materials, Biocompatible
keywords: controlled release; drug microparticles; drug nanoparticles; layer-by-layer; polyelectrolytes