title: Advantage of urine based molecular diagnosis of Zika virus.
abstract: Zika virus (ZIKV) infection is an emerging global health concern, and diagnostic recommendations are currently developing based on new information. Several case or small sample size studies using both urine and blood samples suggest that ZIKV RNA can be detected at higher levels and for a longer time after onset of infection in urine compared to blood. We recommend that urine and serum collection for molecular testing be a standard part of evaluating patients for ZIKV infection, and that urine is a good alternative testing sample when blood collection is problematic.
authors: Department of Urology, William Beaumont Hospital, 3811 West 13 Mile Road, Suite 187, Royal Oak, MI, 48073, USA. laura.lamb@beaumont.org.|Department of Urology, Oakland University William Beaumont School of Medicine, Royal Oak, MI, USA. laura.lamb@beaumont.org.
authors: Laura E
authors: LE
authors: Lamb
authors: Department of Urology, William Beaumont Hospital, 3811 West 13 Mile Road, Suite 187, Royal Oak, MI, 48073, USA.
authors: Sarah N
authors: SN
authors: Bartolone
authors: Department of Molecular Microbiology, Washington University in St. Louis, St. Louis, MO, USA.
authors: Sebla B
authors: SB
authors: Kutluay
authors: Department of Urology, Fundación Santa Fe de Bogotá University Hospital, Bogotá D.C., Colombia.|School of Medicine, Universidad de Los Andes, Bogotá D.C., Colombia.
authors: Daniela
authors: D
authors: Robledo
authors: Subdireccion de Estudios Clínicos, Fundación Santa Fe de Bogotá University Hospital, Bogotá D.C., Colombia.
authors: Alexandra
authors: A
authors: Porras
authors: Department of Urology, Fundación Santa Fe de Bogotá University Hospital, Bogotá D.C., Colombia.|School of Medicine, Universidad de Los Andes, Bogotá D.C., Colombia.
authors: Mauricio
authors: M
authors: Plata
authors: Department of Urology, William Beaumont Hospital, 3811 West 13 Mile Road, Suite 187, Royal Oak, MI, 48073, USA.|Department of Urology, Oakland University William Beaumont School of Medicine, Royal Oak, MI, USA.
authors: Michael B
authors: MB
authors: Chancellor
mesh_terms: D015415:Biomarkers / Q000652:urine*; D057186:Comparative Effectiveness Research; D006801:Humans; D012367:RNA, Viral / Q000032:analysis; D016482:Urinalysis / Q000379:methods*; D000071244:Zika Virus / Q000235:genetics / Q000302:isolation & purification; D000071243:Zika Virus Infection / Q000175:diagnosis / Q000652:urine
chemical_list: D015415:Biomarkers; D012367:RNA, Viral
keywords: Molecular diagnostic; Urine biomarker; Zika infection; Zika virus