title: von Willebrand Factor and Prekallikrein in Plasma Are Associated With Thrombus Volume in Abdominal Aortic Aneurysms.
abstract: OBJECTIVE
  Disruption of the endothelial lining may be one of the events linking intraluminal thrombus and abdominal aortic aneurysm growth. In the present study, we examined whether von Willebrand factor activity in plasma, contact proteins of blood coagulation, and inflammatory biomarkers may be associated with intraluminal thrombus volume in search of a biochemical marker of endothelial damage and thrombus size.
  
  
  METHODS
  Prospective study, correlating potential endothelial biomarkers and intraluminal thrombus volume acquired by computed tomography angiography.
  
  
  METHODS
  Plasma was consecutively obtained from 38 patients with asymptomatic infrarenal abdominal aortic aneurysm. von Willebrand factor activity, thrombin generation time, factor XII, and prekallikrein concentration were measured in plasma on automated and in-house platforms. In total, 8 patients were excluded due to ongoing anticoagulant therapy, renal impairment, or nonappearance, thus leaving 30 patients for further analysis. All patients had computed tomography angiography, and intraluminal volume was quantified off-line by OsiriX 6.5.
  
  
  RESULTS
  Median intraluminal thrombus volume was 42.7 mL. Spearman correlation analysis revealed a positive correlation between thrombus volume, von Willebrand factor activity (ρ = 0.56, P = .0013), and prekallikrein concentration in plasma (ρ = 0.54, P = .002).
  
  
  CONCLUSIONS
  von Willebrand factor activity and concentration of prekallikrein may both be of importance regarding the evolution of thrombus in abdominal aortic aneurysm and possible biomarkers for aneurysm growth.
authors: Department of Vascular Surgery, Rigshospitalet, Blegdamsvej, Copenhagen, Denmark Faculty of Health and Medical Science, University of Copenhagen, Denmark qasam.mohammed.ghulam@regionh.dk.
authors: Qasam M
authors: QM
authors: Ghulam
authors: Department of Vascular Surgery, Rigshospitalet, Blegdamsvej, Copenhagen, Denmark.
authors: Kim K
authors: KK
authors: Bredahl
authors: Department of Biochemistry and Immunology, Hospital of South West, Esbjerg, Denmark Institute of Public Health, University of Southern Denmark.
authors: Jørgen B
authors: JB
authors: Gram
authors: Faculty of Health and Medical Science, University of Copenhagen, Denmark Department of Radiology, Rigshospitalet, Copenhagen, Denmark.
authors: Lars
authors: L
authors: Lönn
authors: Department of Clinical Biochemistry, Rigshospitalet, Copenhagen, Denmark Institute for Clinical Medicine, University of Aarhus, Denmark.
authors: Jens P
authors: JP
authors: Goetze
authors: Department of Vascular Surgery, Rigshospitalet, Blegdamsvej, Copenhagen, Denmark Faculty of Health and Medical Science, University of Copenhagen, Denmark.
authors: Henrik H
authors: HH
authors: Sillesen
authors: Department of Vascular Surgery, Rigshospitalet, Blegdamsvej, Copenhagen, Denmark Faculty of Health and Medical Science, University of Copenhagen, Denmark Copenhagen Academy of Medical Education and Simulation, Capital Region of Denmark, Copenhagen, Denmark.
authors: Jonas P
authors: JP
authors: Eiberg
mesh_terms: D000368:Aged; D017544:Aortic Aneurysm, Abdominal / Q000097:blood* / Q000000981:diagnostic imaging; D001027:Aortography / Q000379:methods; D058070:Asymptomatic Diseases; D015415:Biomarkers / Q000097:blood; D001777:Blood Coagulation; D000072226:Computed Tomography Angiography; D005260:Female; D006801:Humans; D008297:Male; D061330:Multidetector Computed Tomography; D011237:Predictive Value of Tests; D011288:Prekallikrein / Q000032:analysis*; D011379:Prognosis; D011446:Prospective Studies; D013918:Thrombin Time; D013927:Thrombosis / Q000097:blood* / Q000000981:diagnostic imaging; D014841:von Willebrand Factor / Q000032:analysis*
chemical_list: D015415:Biomarkers; D014841:von Willebrand Factor; D011288:Prekallikrein
keywords: abdominal aortic aneurysm; intraluminal thrombus; prekallikrein; thrombus volume; von Willebrand factor