title: Ni-Catalyzed C-C Couplings Using Alkyl Electrophiles.
abstract: Much effort has been devoted to developing new methods using Ni catalysts for the cross-coupling reaction of alkyl electrophiles with organometallic reagents, and significant achievements in this area have emerged during the past two decades. Nickel catalysts have enabled the coupling reaction of not only primary alkyl electrophiles, but also sterically hindered secondary and tertiary alkyl electrophiles possessing β-hydrogens with various organometallic reagents to construct carbon skeletons. In addition, Ni catalysts opened a new era of asymmetric cross-coupling reaction using alkyl halides. Recent progress in nickel-catalyzed cross-coupling reaction of alkyl electrophiles with sp(3)-, sp(2)-, and sp-hybridized organometallic reagents including asymmetric variants as well as mechanistic insights of nickel catalysis are reviewed in this chapter.
authors: Department of Applied Chemistry, Graduate School of Engineering, Osaka University, Suita, Osaka, 565-0871, Japan.
authors: Takanori
authors: T
authors: Iwasaki
authors: Department of Applied Chemistry, Graduate School of Engineering, Osaka University, Suita, Osaka, 565-0871, Japan. kambe@chem.eng.osaka-u.ac.jp.
authors: Nobuaki
authors: N
authors: Kambe
mesh_terms: D000475:Alkenes / Q000737:chemistry; D000478:Alkylation; D001426:Bacterial Proteins / Q000138:chemical synthesis / Q000737:chemistry; D002244:Carbon / Q000737:chemistry*; D002384:Catalysis; D056831:Coordination Complexes / Q000737:chemistry; D008024:Ligands; D009532:Nickel / Q000737:chemistry*; D011789:Quantum Theory; D013237:Stereoisomerism; D014157:Transcription Factors / Q000138:chemical synthesis / Q000737:chemistry
chemical_list: D000475:Alkenes; D001426:Bacterial Proteins; D056831:Coordination Complexes; D008024:Ligands; D014157:Transcription Factors; C056785:salmolysin; D002244:Carbon; D009532:Nickel
keywords: Alkyl halides; Cross-coupling; Homogeneous catalysis; Nickel; Organometallic reagents