title: Synthesis and physicochemical properties of polyacrylamide nanoparticles as photosensitizer carriers.
abstract: At present, polyacrylamide nanoparticles are attractive to drug delivery. However, some physicochemical characteristics of these nanoparticles still need to be further improved in practice. Polyacrylamide nanoparticles with an average size of 80nm and a zeta potential of -30mV were synthesized and used as photosensitizer carriers. The new monobrominated derivatives and parent compounds were the photosensitizers for the photodynamic therapy loaded in the nanocarrier. The physicochemical characterization of the prepared nanoparticles, drug loading, the ability to generate singlet oxygen and chemical stability were investigated. The novel tested nanoparticles exhibited a loading percentage of between 80 and 99%, higher generation of singlet oxygen and good stability in comparison with the corresponding starting reagent. According to these results, the novel polyacrylamide nanoparticles are excellent candidates for drug vehiculization.
authors: Departamento de Farmacia, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Argentina.
authors: M S
authors: MS
authors: Gualdesi
authors: Departamento de Química Orgánica, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba. IMVIB-CONICET, Argentina.
authors: C I Alvarez
authors: CIA
authors: Igarzabal
authors: Departamento de Farmacia, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Argentina.
authors: J
authors: J
authors: Vara
authors: Departamento de Farmacia, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Argentina. Electronic address: crisar@fcq.unc.edu.ar.
authors: C S
authors: CS
authors: Ortiz
mesh_terms: D000180:Acrylic Resins / Q000737:chemistry*; D001399:Azure Stains / Q000737:chemistry; D004337:Drug Carriers; D004355:Drug Stability; D053758:Nanoparticles / Q000737:chemistry*; D009499:Neutral Red / Q000031:analogs & derivatives / Q000737:chemistry; D010316:Particle Size; D010640:Phenothiazines / Q000737:chemistry*; D010778:Photochemotherapy / Q000379:methods; D017319:Photosensitizing Agents / Q000737:chemistry*; D026082:Singlet Oxygen / Q000032:analysis; D000099166:Polyacrylamides
chemical_list: D000180:Acrylic Resins; D001399:Azure Stains; D004337:Drug Carriers; D009499:Neutral Red; D010640:Phenothiazines; D017319:Photosensitizing Agents; D026082:Singlet Oxygen; D000099166:Polyacrylamides; C000620951:monobrominated Azure B; C025819:Azure B
keywords: Nanocarriers; Phenazines derivatives; Phenothiazines derivatives; Photodynamic therapy; Photosensitizers