title: Differential immunohistochemical expression of matrix metalloproteinase-10 (MMP-10) in non-melanoma skin cancers of the head and neck.
abstract: Basal Cell Carcinoma (BCC) and Squamous Cell Carcinoma (SCC) are two common skin malignancies with different potentials for invasion and metastasis. The mechanism responsible for various growth patterns observed in SCC and BCC is still not fully understood. The aim of this study was to investigate the expression of matrix metalloproteinase-10 in non-melanoma skin cancers, including BCC and SCC of the head and neck. The study group consisted of 60 specimens, including 30 BCC and 30 cutaneous SCC of the head and neck. Sections of tumor biopsy samples were immunohistochemically examined for the expression of MMP-10. Data were analyzed by SPSS (V.21) using Mann-Whitney and Kruskal Wallis tests. We found higher immunohistochemical expression of MMP-10 in tumor epithelium and stroma of SCC as compared with BCC. However, this difference was significant only in tumor epithelium (P=0.000). Moreover, the level of MMP-10 expression in tumor epithelium of grades III and II of SCC was significantly greater compared to grade I tumors (P<0.05).Our results suggest that the level of the MMP-10 expression in tumor epithelium of cutaneous SCC and BCC may contribute to the different invasive patterns observed in these tumors. Also, the expression of MMP-10 is associated with tumor differentiation in cutaneous HNSCC.
authors: Oral and Dental Disease Research Center, Department of Oral and Maxillofacial Pathology, School of Dentistry, Zahedan University of Medical Sciences, Zahedan, Iran. Electronic address: Kadeh@zaums.ac.ir.
authors: Hamideh
authors: H
authors: Kadeh
authors: Oral and Dental Disease Research Center, Department of Oral and Maxillofacial Pathology, School of Dentistry, Zahedan University of Medical Sciences, Zahedan, Iran. Electronic address: Shirin.Saravani@gmail.com.
authors: Shirin
authors: S
authors: Saravani
authors: Department of Pathology, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran. Electronic address: Heydari3688@gmail.com.
authors: Fatemeh
authors: F
authors: Heydari
authors: General Dentist, Zahedan, Iran. Electronic address: Saeed.shahraki@yahoo.com.
authors: Saeed
authors: S
authors: Shahraki
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002280:Basal Cell Carcinoma / Q000378:metabolism* / Q000473:pathology; D002294:Carcinoma, Squamous Cell / Q000378:metabolism* / Q000473:pathology; D005260:Female; D006258:Head and Neck Neoplasms / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D053506:Matrix Metalloproteinase 10 / Q000378:metabolism*; D008875:Middle Aged; D060787:Neoplasm Grading; D012878:Skin Neoplasms / Q000378:metabolism* / Q000473:pathology
chemical_list: D053506:Matrix Metalloproteinase 10
keywords: Basal cell carcinoma; Cutaneous squamous cell carcinoma; Immunohistochemistry; MMP-10