title: Association between air pollution and development of atrial fibrillation: A meta-analysis of observational studies.
abstract: BACKGROUND
  Current evidence suggests that gaseous or particulate pollutants may increase the risk of atrial fibrillation (AF), although this association is still uncertain.
  
  
  METHODS
  We conducted a systematic review of literature using PubMed, Ovid, Embase and Web of Science to identify studies reporting on the association between gaseous (ozone, carbon monoxide, sulfur dioxide, and nitrogen dioxide) or particulate matter 2.5 (PM2.5) and AF risk published until March 2015. The overall effect estimate was presented as the population-attributable risks with 95% CI. We used both fix-effects and random effects models to calculate the overall effect estimate.
  
  
  RESULTS
  We retrieved 4 studies, involving 461,441 participants. There was a statistically significant association between AF development and all gaseous pollutant as well as PM2.5[NO: 1.19% (0.70-1.67%), CO: 0.60 (0.20-1.09), SO2: 0.90 (0.60-1.28), O3: 1.09 (0.20-1.86), PM2.5: 0.89 (0.20-1.57)].
  
  
  CONCLUSIONS
  Our comprehensive meta-analysis suggests that gaseous or particulate pollutants are associated with the increased risk of AF.
authors: Tianjin Key Laboratory of Ionic-Molecular Function of Cardiovascular Disease, Department of Cardiology, Tianjin Institute of Cardiology, Second Hospital of Tianjin Medical University, Tianjin 300211, People's Republic of China.
authors: Qingmiao
authors: Q
authors: Shao
authors: Tianjin Key Laboratory of Ionic-Molecular Function of Cardiovascular Disease, Department of Cardiology, Tianjin Institute of Cardiology, Second Hospital of Tianjin Medical University, Tianjin 300211, People's Republic of China. Electronic address: liutongdoc@126.com.
authors: Tong
authors: T
authors: Liu
authors: First Department of Cardiology, University of Ioannina Medical School, Ioannina, Greece.
authors: Panagiotis
authors: P
authors: Korantzopoulos
authors: Tianjin Key Laboratory of Ionic-Molecular Function of Cardiovascular Disease, Department of Cardiology, Tianjin Institute of Cardiology, Second Hospital of Tianjin Medical University, Tianjin 300211, People's Republic of China.
authors: Zhiwei
authors: Z
authors: Zhang
authors: Tianjin Key Laboratory of Ionic-Molecular Function of Cardiovascular Disease, Department of Cardiology, Tianjin Institute of Cardiology, Second Hospital of Tianjin Medical University, Tianjin 300211, People's Republic of China.
authors: Jianping
authors: J
authors: Zhao
authors: Tianjin Key Laboratory of Ionic-Molecular Function of Cardiovascular Disease, Department of Cardiology, Tianjin Institute of Cardiology, Second Hospital of Tianjin Medical University, Tianjin 300211, People's Republic of China. Electronic address: tjcardiol@126.com.
authors: Guangping
authors: G
authors: Li
mesh_terms: D000393:Air Pollutants / Q000009:adverse effects*; D001281:Atrial Fibrillation / Q000453:epidemiology / Q000209:etiology*; D014943:Global Health; D006801:Humans; D015994:Incidence; D064887:Observational Studies as Topic; D052638:Particulate Matter / Q000009:adverse effects*; D013997:Time Factors
chemical_list: D000393:Air Pollutants; D052638:Particulate Matter
keywords: Air pollution; Atrial fibrillation; Gaseous pollutant; Meta-analysis; Particulate matter