title: Measuring cardiac output in children undergoing cardiac catheterization: comparison between the Fick method and PRAM (pressure recording analytical method).
abstract: BACKGROUND
  Pressure recording analytical method (PRAM) is a novel, arterial pulse contour method for measuring cardiac output (CO). Validation studies of PRAM in children are few, and have shown contradictory results. The aim of the study was to compare the MostCare®-PRAM vs the Fick method of cardiac output estimation (reference method).
  
  
  METHODS
  This is a single-center, prospective observational study in 52 pediatric patients who underwent diagnostic right and left heart catheterization. Cardiac index (CI) measurements with the MostCare®-PRAM vs the Fick method were obtained under hemodynamically stable conditions.
  
  
  RESULTS
  Forty CI measurements were performed. The data showed good agreement between CIFickand CIPRAM: r2= 0.90 (P < 0.001), mean bias -0.075, limits of agreement from -0.56 to 0.41. The percentage error was 17%. Comparable results were obtained for patients <20 kg (r2= 0.87, P < 0.001), mean bias -0.135, limits of agreement from -0.35 to 0.62, percentage of error 17%.
  
  
  CONCLUSIONS
  In pediatric patients undergoing diagnostic right and left heart catheterization, the MostCare®-PRAM was shown to estimate CI with a good level of agreement with the Fick method measurements.
authors: Department of Anesthesia, Critical Care and Pain Medicine, Hospital Clínico Universitario, Valencia, Spain. jmalonso@me.com.
authors: José M
authors: JM
authors: Alonso-Iñigo
authors: Department of Anesthesia and Critical Care, Hospital Universitari i Politècnic La Fe, Valencia, Spain.
authors: Francisco J
authors: FJ
authors: Escribá
authors: Department of Pediatric Cardiology, Hospital Universitari i Politècnic La Fe, Valencia, Spain.
authors: José I
authors: JI
authors: Carrasco
authors: Department of Anesthesia, Critical Care and Pain Medicine, Hospital Universitari de la Ribera, Alzira, Spain.
authors: María J
authors: MJ
authors: Fas
authors: Department of Anesthesia and Critical Care, Hospital Universitari i Politècnic La Fe, Valencia, Spain.
authors: Pilar
authors: P
authors: Argente
authors: Department of Surgery, Research Unit, Hospital Universitari de la Ribera, Alzira, Spain.
authors: José M
authors: JM
authors: Galvis
authors: Department of Anesthesia, Critical Care and Pain Medicine, Hospital Universitari de la Ribera, Alzira, Spain.
authors: José E
authors: JE
authors: Llopis
mesh_terms: D000293:Adolescent; D006328:Cardiac Catheterization; D002302:Cardiac Output; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008991:Monitoring, Physiologic / Q000295:instrumentation* / Q000379:methods*; D011446:Prospective Studies; D015203:Reproducibility of Results
keywords: Fick method; cardiac output; congenital heart disease; pediatric; pressure recording analytical method; pulse contour methods