title: Operationalizing NIMH Research Domain Criteria (RDoC) in naturalistic clinical settings.
abstract: Recently, the National Institute of Mental Health (NIMH) introduced the Research Domain Criteria (RDoC) initiative to address two major challenges facing the field of psychiatry: (1) the lack of new effective personalized treatments for psychiatric disorders, and (2) the limitations associated with categorically defined psychiatric disorders. Although the potential of RDoC to revolutionize personalized psychiatric medicine and psychiatric nosology has been acknowledged, it is unclear how to implement RDoC in naturalistic clinical settings as part of routine outcomes research. In this article, the authors present the major RDoC principles and then show how these principles are operationalized in The Menninger Clinic's McNair Initiative for Neuroscience Discovery-Menninger & Baylor College of Medicine (MIND-MB) study. The authors discuss how RDoC-informed outcomes-based assessment in clinical settings can transform personalized clinical care through multimodal treatments.
authors: Department of Psychology, University of Houston, Houston, Texas.|The Menninger Clinic, Houston, Texas.
authors: Carla
authors: C
authors: Sharp
authors: The Menninger Clinic, Houston, Texas.|Baylor College of Medicine, Houston, Texas.
authors: J Christopher
authors: JC
authors: Fowler
authors: Baylor College of Medicine, Houston, Texas.
authors: Ramiro
authors: R
authors: Salas
authors: Baylor College of Medicine, Houston, Texas.|Michael DeBakey Veterans Affairs Medical Center, Houston, Texas.
authors: David
authors: D
authors: Nielsen
authors: The Menninger Clinic, Houston, Texas.|Baylor College of Medicine, Houston, Texas.
authors: Jon
authors: J
authors: Allen
authors: The Menninger Clinic, Houston, Texas.|Baylor College of Medicine, Houston, Texas.
authors: John
authors: J
authors: Oldham
authors: Michael DeBakey Veterans Affairs Medical Center, Houston, Texas.
authors: Thomas
authors: T
authors: Kosten
authors: The Menninger Clinic, Houston, Texas.|Baylor College of Medicine, Houston, Texas.
authors: Sanjay
authors: S
authors: Mathew
authors: The Menninger Clinic, Houston, Texas.|Baylor College of Medicine, Houston, Texas.
authors: Alok
authors: A
authors: Madan
authors: The Menninger Clinic, Houston, Texas.|University of Hawaii, Hilo, Hawaii.
authors: B Christopher
authors: BC
authors: Frueh
authors: The Menninger Clinic, Houston, Texas.|University College of London, London, UK.
authors: Peter
authors: P
authors: Fonagy
mesh_terms: D000293:Adolescent; D000328:Adult; D005260:Female; D006801:Humans; D008297:Male; D001523:Mental Disorders / Q000145:classification / Q000175:diagnosis*; D008875:Middle Aged; D009315:National Institute of Mental Health (U.S.) / Q000592:standards*; D017063:Outcome Assessment, Health Care / Q000379:methods* / Q000592:standards; D057285:Precision Medicine / Q000379:methods* / Q000592:standards; D011570:Psychiatry / Q000379:methods* / Q000592:standards; D014481:United States; D055815:Young Adult