title: Carcinogenic Potential of High Aspect Ratio Carbon Nanomaterials.
abstract: Engineered nanomaterials, including high aspect ratio carbon nanomaterials, are often commercialized without a complete human risk assessment and safety evaluation. A health concern has been raised that high aspect ratio nanomaterials such as carbon nanotubes may cause unintended health consequences, such as asbestos-like lung cancer and mesothelioma, when chronically inhaled. Considering the widespread industrial and clinical applications and the increasing incidence of human exposure to nanomaterials, it is important to address the issue of nanomaterial carcinogenicity in a timely manner. This review summarizes recent advances in nanomaterial genotoxicity and carcinogenicity with a focus on high aspect ratio carbon nanotubes, and discusses current knowledge gaps and future research directions.
authors: Siriraj Center of Excellence for Stem Cell Research, Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand; Department of Pharmaceutical Sciences, West Virginia University, Morgantown, WV 26506, USA.
authors: Sudjit
authors: S
authors: Luanpitpong
authors: Allergy and Clinical Immunology Branch, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA.
authors: Liying
authors: L
authors: Wang
authors: Allergy and Clinical Immunology Branch, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA.
authors: Donna C
authors: DC
authors: Davidson
authors: Department of Biochemistry, West Virginia University, Morgantown, WV 26506, USA; Mary Babb Randolph Cancer Center, West Virginia University, Morgantown, WV 26506, USA.
authors: Heimo
authors: H
authors: Riedel
authors: Department of Pharmaceutical Sciences, West Virginia University, Morgantown, WV 26506, USA; Mary Babb Randolph Cancer Center, West Virginia University, Morgantown, WV 26506, USA.
authors: Yon
authors: Y
authors: Rojanasakul
keywords: carbon nanotubes; carcinogenicity; genotoxicity; pulmonary exposure