title: An update on the epigenetics of glioblastomas.
abstract: Glioblastomas, also known as glioblastoma multiforme (GBM), are the most aggressive and malignant type of primary brain tumor in adults, exhibiting notable variability at the histopathological, genetic and epigenetic levels. Recently, epigenetic alterations have emerged as a common hallmark of many tumors, including GBM. Considering that a deeper understanding of the epigenetic modifications that occur in GBM may increase the knowledge regarding the tumorigenesis, progression and recurrence of this disease, in this review we discuss the recent major advances in GBM epigenetics research involving histone modification, glioblastoma stem cells, DNA methylation, noncoding RNAs expression, including their main alterations and the use of epigenetic therapy as a valid option for GBM treatment.
authors: Molecular Biology Laboratory, Institute of Biological Sciences, Federal University of Pará (Universidade Federal do Pará-UFPA)-Belém, Pará, Brazil.
authors: Wallax Augusto Silva
authors: WA
authors: Ferreira
authors: Molecular Biology Laboratory, Institute of Biological Sciences, Federal University of Pará (Universidade Federal do Pará-UFPA)-Belém, Pará, Brazil.
authors: Danilo do Rosário
authors: Ddo R
authors: Pinheiro
authors: Molecular Biology Laboratory, Institute of Biological Sciences, Federal University of Pará (Universidade Federal do Pará-UFPA)-Belém, Pará, Brazil.
authors: Carlos Antonio da
authors: CA
authors: Costa Junior
authors: Molecular Biology Laboratory, Institute of Biological Sciences, Federal University of Pará (Universidade Federal do Pará-UFPA)-Belém, Pará, Brazil.
authors: Symara
authors: S
authors: Rodrigues-Antunes
authors: Molecular Biology Laboratory, Institute of Biological Sciences, Federal University of Pará (Universidade Federal do Pará-UFPA)-Belém, Pará, Brazil.
authors: Mariana Diniz
authors: MD
authors: Araújo
authors: Molecular Biology Laboratory, Institute of Biological Sciences, Federal University of Pará (Universidade Federal do Pará-UFPA)-Belém, Pará, Brazil.
authors: Mariceli Baia
authors: MB
authors: Leão Barros
authors: Molecular Biology Laboratory, Institute of Biological Sciences, Federal University of Pará (Universidade Federal do Pará-UFPA)-Belém, Pará, Brazil.
authors: Adriana Corrêa de Souza
authors: AC
authors: Teixeira
authors: Molecular Biology Laboratory, Institute of Biological Sciences, Federal University of Pará (Universidade Federal do Pará-UFPA)-Belém, Pará, Brazil.
authors: Thamirys Aline Silva
authors: TA
authors: Faro
authors: Human Cytogenetics Laboratory, Institute of Biological Sciences, UFPA-Belém, Pará, Brazil.
authors: Rommel Rodriguez
authors: RR
authors: Burbano
authors: Tissue Culture & Cytogenetics Laboratory, Evandro Chagas Institute (Instituto Evandro Chagas), Belém, Pará, Brazil.
authors: Edivaldo Herculano Correa de
authors: EH
authors: Oliveira
authors: Molecular Biology Laboratory, Institute of Biological Sciences, Federal University of Pará (Universidade Federal do Pará-UFPA)-Belém, Pará, Brazil.
authors: Maria Lúcia
authors: ML
authors: Harada
authors: Molecular Biology Laboratory, Institute of Biological Sciences, Federal University of Pará (Universidade Federal do Pará-UFPA)-Belém, Pará, Brazil.
authors: Bárbara do Nascimento
authors: Bdo N
authors: Borges
mesh_terms: D014408:Biomarkers, Tumor / Q000235:genetics; D001932:Brain Neoplasms / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D044127:Epigenesis, Genetic; D015972:Gene Expression Regulation, Neoplastic; D005909:Glioblastoma / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D006801:Humans
chemical_list: D014408:Biomarkers, Tumor
keywords: DNA methylation; astrocytomas; biomarkers; brain tumors; cancer; epigenetic regulation; genetic; glioblastoma; gliomas; targeted therapy