title: Cytokine changes in newborns with therapeutic hypothermia after hypoxic ischemic encephalopathy.
abstract: This study aimed to examine changes in cytokines according to therapeutic hypothermia (TH) for newborn hypoxic ischemic encephalopathy (HIE).
  
  
  
  We studied 20 neonates who were admitted with a diagnosis of HIE in the neonatal intensive care unit. Cytokine concentration assay was carried out for neonates (n=12) who received TH and neonates (n=8) who were not treated with hypothermia by collecting blood sample at 12, 48 and 120 h after birth.
  
  
  
  At 48 h after birth, interleukin (IL)-6 in the normothermia group was higher than that in the hypothermia group (P=0.010). At 48 h after birth, IL-10 was higher in the hypothermia group than in the normothermia group (P=0.038).
  
  
  
  This study confirmed that TH performs a role in the prevention of inflammatory process by way of maintaining proinflammatory cytokine IL-6 at low levels and anti-inflammatory cytokines IL-10 at high levels.
authors: Department of Pediatrics, The Catholic University of Korea, Seoul St Mary's Hospital, Seoul, Republic of Korea.
authors: C J
authors: CJ
authors: Moon
authors: Department of Pediatrics, The Catholic University of Korea, Seoul St Mary's Hospital, Seoul, Republic of Korea.
authors: Y A
authors: YA
authors: Youn
authors: Department of Pediatrics, The Catholic University of Korea, Seoul St Mary's Hospital, Seoul, Republic of Korea.
authors: S K
authors: SK
authors: Yum
authors: Department of Pediatrics, The Catholic University of Korea, Seoul St Mary's Hospital, Seoul, Republic of Korea.
authors: I K
authors: IK
authors: Sung
mesh_terms: D016022:Case-Control Studies; D004569:Electroencephalography; D004797:Enzyme-Linked Immunosorbent Assay; D005865:Gestational Age; D006801:Humans; D007036:Hypothermia, Induced / Q000379:methods*; D020925:Hypoxia-Ischemia, Brain / Q000097:blood / Q000628:therapy*; D007231:Infant, Newborn; D016753:Interleukin-10 / Q000097:blood*; D015850:Interleukin-6 / Q000097:blood*; D012189:Retrospective Studies; D012720:Severity of Illness Index; D018709:Statistics, Nonparametric; D013997:Time Factors
chemical_list: D015850:Interleukin-6; D016753:Interleukin-10