title: Automated quantification of amyloid positron emission tomography: a comparison of PMOD and MIMneuro.
abstract: OBJECTIVE
  The aim of this study was to examine and compare two automated quantitative software tools (PMOD and MIMneuro) for the quantification of amyloid positron emission tomography (PET).
  
  
  METHODS
  A total of 30 subjects-15 Alzheimer's disease (AD) patients and 15 cognitively normal age- and sex-matched controls-were enrolled. All subjects underwent structural volumetric magnetic resonance imaging (MRI) and amyloid PET scans with F-18 florbetaben. Regional standardized uptake value ratios (SUVRs) using the cerebellar cortex as a reference region were obtained using PMOD and MIMneuro.
  
  
  RESULTS
  The SUVRs using both PMOD and MIMneuro showed high discriminatory power between the AD patients and cognitively normal controls. While PMOD and MIMneuro yielded significantly different SUVRs in some brain regions, the two methods had good overall agreement.
  
  
  CONCLUSIONS
  MIMneuro provides comparable performance to PMOD without the need to acquire brain MRI. Therefore, MIMneuro might be suitable for clinical use to determine amyloid positivity.
authors: Department of Radiology, St. Vincent's Hospital, College of Medicine, The Catholic University of Korea, Suwon, Republic of Korea.
authors: Woo Hee
authors: WH
authors: Choi
authors: Department of Psychiatry, St. Vincent's Hospital, College of Medicine, The Catholic University of Korea, Suwon, Republic of Korea.
authors: Yoo Hyun
authors: YH
authors: Um
authors: Department of Radiology, St. Vincent's Hospital, College of Medicine, The Catholic University of Korea, Suwon, Republic of Korea.
authors: Won Sang
authors: WS
authors: Jung
authors: Department of Radiology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, 222 Banpo-daero, Seocho-gu, Seoul, 137-701, Republic of Korea. nm@cmcnu.or.kr.
authors: Sung Hoon
authors: SH
authors: Kim
mesh_terms: D000368:Aged; D000682:Amyloid / Q000378:metabolism*; D001331:Automation; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D008297:Male; D049268:Positron-Emission Tomography; D012372:ROC Curve; D012189:Retrospective Studies
chemical_list: D000682:Amyloid
keywords: Alzheimer’s disease; Florbetaben; PET; Quantification; β-Amyloid