title: Geographic tongue and psoriasis: clinical, histopathological, immunohistochemical and genetic correlation - a literature review.
abstract: Geographic tongue is a chronic, inflammatory, and immune-mediated oral lesion of unknown etiology. It is characterized by serpiginous white areas around the atrophic mucosa, which alternation between activity, remission and reactivation at various locations gave the names benign migratory glossitis and wandering rash of the tongue. Psoriasis is a chronic inflammatory disease with frequent cutaneous involvement and an immunogenetic basis of great importance in clinical practice. The association between geographic tongue and psoriasis has been demonstrated in various studies, based on observation of its fundamental lesions, microscopic similarity between the two conditions and the presence of a common genetic marker, human leukocyte antigen (HLA) HLA-C*06. The difficulty however in accepting the diagnosis of geographic tongue as oral psoriasis is the fact that not all patients with geographic tongue present psoriasis. Some authors believe that the prevalence of geographic tongue would be much greater if psoriatic patients underwent thorough oral examination. This study aimed to develop a literature review performed between 1980 and 2014, in which consultation of theses, dissertations and selected scientific articles were conducted through search in Scielo and Bireme databases, from Medline and Lilacs sources, relating the common characteristics between geographic tongue and psoriasis. We observed that the frequency of oral lesions is relatively common, but to establish a correct diagnosis of oral psoriasis, immunohistochemical and genetic histopathological analyzes are necessary, thus highlighting the importance of oral examination in psoriatic patients and cutaneous examination in patients with geographic tongue.
authors: Universidade Federal Fluminense (UFF) - Niterói (RJ), Brazil.
authors: Bruna Lavinas Sayed
authors: BL
authors: Picciani
authors: Universidade Federal Fluminense (UFF) - Niterói (RJ), Brazil.
authors: Tábata Alves
authors: TA
authors: Domingos
authors: Universidade Federal Fluminense (UFF) - Niterói (RJ), Brazil.
authors: Thays
authors: T
authors: Teixeira-Souza
authors: Universidade Federal Fluminense (UFF) - Niterói (RJ), Brazil.
authors: Vanessa de Carla Batista Dos
authors: Vde C
authors: Santos
authors: Universidade de Marília (Unimar) - Marília (SP), Brazil.
authors: Heron Fernando de Sousa
authors: HF
authors: Gonzaga
authors: Universidade do Estado do Rio de Janeiro (UERJ) - Rio de Janeiro (RJ), Brazil.
authors: Juliana
authors: J
authors: Cardoso-Oliveira
authors: Universidade do Estado do Rio de Janeiro (UERJ) - Rio de Janeiro (RJ), Brazil.
authors: Alexandre Carlos
authors: AC
authors: Gripp
authors: Universidade Federal Fluminense (UFF) - Niterói (RJ), Brazil.
authors: Eliane Pedra
authors: EP
authors: Dias
authors: Universidade do Estado do Rio de Janeiro (UERJ) - Rio de Janeiro (RJ), Brazil.
authors: Sueli
authors: S
authors: Carneiro
mesh_terms: D001706:Biopsy; D005260:Female; D005819:Genetic Markers; D005929:Glossitis, Benign Migratory / Q000150:complications / Q000235:genetics* / Q000473:pathology* / Q000628:therapy; D006680:HLA Antigens / Q000032:analysis; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008488:Medical Illustration; D011565:Psoriasis / Q000150:complications / Q000235:genetics* / Q000473:pathology*; D014059:Tongue / Q000473:pathology*; D014063:Tongue, Fissured / Q000473:pathology
chemical_list: D005819:Genetic Markers; D006680:HLA Antigens