title: Catalytic Chan-Lam coupling using a 'tube-in-tube' reactor to deliver molecular oxygen as an oxidant.
abstract: A flow system to perform Chan-Lam coupling reactions of various amines and arylboronic acids has been realised employing molecular oxygen as an oxidant for the re-oxidation of the copper catalyst enabling a catalytic process. A tube-in-tube gas reactor has been used to simplify the delivery of the oxygen accelerating the optimisation phase and allowing easy access to elevated pressures. A small exemplification library of heteroaromatic products has been prepared and the process has been shown to be robust over extended reaction times.
authors: Department of Chemistry, Durham University, South Road, Durham, DH1 3LE, United Kingdom.
authors: Carl J
authors: CJ
authors: Mallia
authors: Syngenta, Jealott's Hill International Research Centre, Bracknell, Berkshire, RG42 6EY, United Kingdom.
authors: Paul M
authors: PM
authors: Burton
authors: Syngenta, Jealott's Hill International Research Centre, Bracknell, Berkshire, RG42 6EY, United Kingdom.
authors: Alexander M R
authors: AM
authors: Smith
authors: Syngenta, Jealott's Hill International Research Centre, Bracknell, Berkshire, RG42 6EY, United Kingdom.
authors: Gary C
authors: GC
authors: Walter
authors: Department of Chemistry, Durham University, South Road, Durham, DH1 3LE, United Kingdom.
authors: Ian R
authors: IR
authors: Baxendale
keywords: Chan–Lam coupling; flow chemistry; gases in flow; oxygen; “tube-in-tube”