title: Cerebral Autoregulation Real-Time Monitoring.
abstract: Cerebral autoregulation is a mechanism which maintains constant cerebral blood flow (CBF) despite changes in mean arterial pressure (MAP). Assessing whether this mechanism is intact or impaired and determining its boundaries is important in many clinical settings, where primary or secondary injuries to the brain may occur. Herein we describe the development of a new ultrasound tagged near infra red light monitor which tracks CBF trends, in parallel, it continuously measures blood pressure and correlates them to produce a real time autoregulation index. Its performance is validated in both in-vitro experiment and a pre-clinical case study. Results suggest that using such a tool, autoregulation boundaries as well as its impairment or functioning can be identified and assessed. It may therefore assist in individualized MAP management to ensure adequate organ perfusion and reduce the risk of postoperative complications, and might play an important role in patient care.
authors: Ornim Medical Ltd, Kfar Saba, Israel.
authors: Adi
authors: A
authors: Tsalach
authors: Ornim Medical Ltd, Kfar Saba, Israel.
authors: Eliahu
authors: E
authors: Ratner
authors: Ornim Medical Ltd, Kfar Saba, Israel.
authors: Stas
authors: S
authors: Lokshin
authors: Ornim Medical Ltd, Kfar Saba, Israel.
authors: Zmira
authors: Z
authors: Silman
authors: Ornim Medical Ltd, Kfar Saba, Israel.
authors: Ilan
authors: I
authors: Breskin
authors: Ornim Medical Ltd, Kfar Saba, Israel.
authors: Nahum
authors: N
authors: Budin
authors: Ornim Medical Ltd, Kfar Saba, Israel.
authors: Moshe
authors: M
authors: Kamar
mesh_terms: D000818:Animals; D062186:Arterial Pressure / Q000502:physiology; D001783:Blood Flow Velocity / Q000502:physiology; D001794:Blood Pressure / Q000502:physiology; D002560:Cerebrovascular Circulation / Q000502:physiology*; D005260:Female; D006706:Homeostasis / Q000502:physiology; D013552:Swine