title: Microwave-assisted synthesis and antifungal activity of novel fused Osthole derivatives.
abstract: Based on the microwave-assisted synthetic protocol developed in our previous work, we have synthesized a series of novel furo[3,2-c]coumarins as fused Osthole derivatives, via the reaction of 4-hydroxycoumarins and β-ketoesters catalyzed by DMAP. All the target compounds were evaluated in vitro for their antifungal activity against six phytopathogenic fungi, some compounds exhibited potential activity in the primary assays. Especially compounds 6c, 7b, 8b and 8c (shown in Fig. 1) were the most active ones, EC50values of these four compounds against Colletotrichum capsica, Botrytis cinerea and Rhizoctonia solani were further investigated. 6c was identified as the most promising candidate with the EC50value at 0.110 μM against Botrytis cinerea and 0.040 μM against Colletotrichum capsica, respectively, representing better antifungal activity than that of the commonly used fungicide Azoxystrobin.
authors: Jiangsu Key Laboratory of Pesticide Science, College of Sciences, Nanjing Agricultural University, Nanjing 210095, PR China.
authors: Ming-Zhi
authors: MZ
authors: Zhang
authors: Jiangsu Key Laboratory of Pesticide Science, College of Sciences, Nanjing Agricultural University, Nanjing 210095, PR China.
authors: Rong-Rong
authors: RR
authors: Zhang
authors: Jiangsu Key Laboratory of Pesticide Science, College of Sciences, Nanjing Agricultural University, Nanjing 210095, PR China.
authors: Jia-Qun
authors: JQ
authors: Wang
authors: Jiangsu Key Laboratory of Pesticide Science, College of Sciences, Nanjing Agricultural University, Nanjing 210095, PR China.
authors: Xiang
authors: X
authors: Yu
authors: Jiangsu Key Laboratory of Pesticide Science, College of Sciences, Nanjing Agricultural University, Nanjing 210095, PR China.
authors: Ya-Ling
authors: YL
authors: Zhang
authors: Jiangsu Key Laboratory of Pesticide Science, College of Sciences, Nanjing Agricultural University, Nanjing 210095, PR China.
authors: Qing-Qing
authors: QQ
authors: Wang
authors: Jiangsu Key Laboratory of Pesticide Science, College of Sciences, Nanjing Agricultural University, Nanjing 210095, PR China. Electronic address: njzhangwh@126.com.
authors: Wei-Hua
authors: WH
authors: Zhang
mesh_terms: D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D060326:Chemistry Techniques, Synthetic; D003374:Coumarins / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D015195:Drug Design; D005658:Fungi / Q000187:drug effects; D008872:Microwaves
chemical_list: D000935:Antifungal Agents; D003374:Coumarins; C046627:osthol
keywords: Antifungal activity; Furo[3,4-c]coumarin; Microwave-assisted; Osthole; Synthesis