title: Label-Free Electric Monitoring of Human Cancer Cells as a Potential Diagnostic Tool.
abstract: Dielectrophoresis is widely used for cell characterization, and the exerted force on cells depends on the difference of polarizability between the latter and the surrounding medium. This physical phenomenon is translated by the real part of the Clausius-Mossotti factor. It is mostly modeled from the imaginary part, measured by electrorotation. The method described here measures experimentally the real part of the Clausius-Mossotti factor. It relies on the cell velocity when submitted to pure dielectrophoresis, and it was conducted on several human cell lines, at different times. A variety of cell lines was evaluated, from different organs or representative of different stages of cancer, with promising findings for early cancer detection.
authors: Université Grenoble Alpes , F-38000 Grenoble, France.|CNRS, LTM, F-38000 Grenoble, France.
authors: Clarisse
authors: C
authors: Vaillier
authors: Université Grenoble Alpes , F-38000 Grenoble, France.|CNRS, LTM, F-38000 Grenoble, France.
authors: Thibault
authors: T
authors: Honegger
authors: Université Grenoble Alpes , F-38000 Grenoble, France.|CEA, iRTSV, Biologie à Grande Echelle, F-38054 Grenoble, France.|INSERM, U1038, F-38054 Grenoble, France.
authors: Frédérique
authors: F
authors: Kermarrec
authors: Université Grenoble Alpes , F-38000 Grenoble, France.|CEA, iRTSV, Biologie à Grande Echelle, F-38054 Grenoble, France.|INSERM, U1038, F-38054 Grenoble, France.
authors: Xavier
authors: X
authors: Gidrol
authors: Université Grenoble Alpes , F-38000 Grenoble, France.|CNRS, LTM, F-38000 Grenoble, France.
authors: David
authors: D
authors: Peyrade
mesh_terms: D045744:Cell Line, Tumor; D002465:Cell Movement; D055088:Early Detection of Cancer / Q000295:instrumentation*; D004566:Electrodes; D004586:Electrophoresis / Q000295:instrumentation*; D004867:Equipment Design; D006801:Humans; D056656:Lab-On-A-Chip Devices; D009369:Neoplasms / Q000175:diagnosis*; D055672:Static Electricity