title: Spinal sensory circuits in motion.
abstract: The role of sensory feedback in shaping locomotion has been long debated. Recent advances in genetics and behavior analysis revealed the importance of proprioceptive pathways in spinal circuits. The mechanisms underlying peripheral mechanosensation enabled to unravel the networks that feedback to spinal circuits in order to modulate locomotion. Sensory inputs to the vertebrate spinal cord were long thought to originate from the periphery. Recent studies challenge this view: GABAergic sensory neurons located within the spinal cord have been shown to relay mechanical and chemical information from the cerebrospinal fluid to motor circuits. Innovative approaches combining genetics, quantitative analysis of behavior and optogenetics now allow probing the contribution of these sensory feedback pathways to locomotion and recovery following spinal cord injury.
authors: Institut du Cerveau et de la Moelle Épinière, Campus Hospitalier Pitié-Salpêtrière, 47 bld de l'Hôpital, 75013 Paris, France; UPMC Univ., Paris 06, France; Inserm UMR S1127, France; CNRS UMR 7225, France.
authors: Urs Lucas
authors: UL
authors: Böhm
authors: Institut du Cerveau et de la Moelle Épinière, Campus Hospitalier Pitié-Salpêtrière, 47 bld de l'Hôpital, 75013 Paris, France; UPMC Univ., Paris 06, France; Inserm UMR S1127, France; CNRS UMR 7225, France. Electronic address: claire.wyart@icm-institute.org.
authors: Claire
authors: C
authors: Wyart
mesh_terms: D000818:Animals; D059330:GABAergic Neurons / Q000502:physiology; D006801:Humans; D008124:Locomotion / Q000502:physiology*; D013116:Spinal Cord / Q000502:physiology*; D013119:Spinal Cord Injuries