title: Usefulness of speckle myocardial imaging modalities for differential diagnosis of left ventricular non-compaction of the myocardium.
abstract: OBJECTIVE
  Current diagnostic criteria for left ventricular non-compaction (LVNC) may result in over-diagnosis of the disease. We evaluate the role of speckle imaging in differential diagnosis of LVNC.
  
  
  RESULTS
  We included all patients who, between January 2012 and May 2015, fulfilled currently accepted criteria for LVNC (28 patients). A control group of 28 healthy individuals and a third group of 13 patients with dilated cardiomyopathy (DCM) were created. Speckle-tracking echocardiography was performed in all groups. Thirteen patients with LVNC had an ejection fraction (EF) <50% (33.5%, SD 10). When compared to controls, patients with LVNC and EF<50% had a larger LV, larger left atrial diameter (LA), reduced e', and reduced global longitudinal strain (GLS). All but one patient with LVNC and EF<50% showed an abnormal LV rotation. This abnormal pattern was observed in 4 LVNC patients (27%) with EF≥50% and in none of the controls. In patients with LVNC, EF ≥50%, and abnormal rotation, GLS was lower than in controls, (-17 (SD 3) vs -21 (SD 3)). Rigid body rotation (RBR) was also observed in 2 DCM patients, with significant differences in EF, GLS, LV diameters relative to the rest of the DCM group.
  
  
  CONCLUSIONS
  In patients who fulfil the morphologic criteria for LVNC, speckle myocardial imaging techniques could be useful in differentiating between healthy individuals (functionally normal LV) and patients with LVNC (with functional abnormalities in the myocardium in spite of a preserved EF).
authors: Hospital Universitario Fundación Jiménez Díaz - quirónsalud, Universidad Autónoma de Madrid, Madrid, Spain. Electronic address: mcortes@secardiologia.es.
authors: Marcelino
authors: M
authors: Cortés
authors: Hospital Universitario de Móstoles, Móstoles, Madrid, Spain.
authors: María Reyes
authors: MR
authors: Oliva
authors: Hospital Universitario Fundación Jiménez Díaz - quirónsalud, Universidad Autónoma de Madrid, Madrid, Spain.
authors: Miguel
authors: M
authors: Orejas
authors: Hospital Universitario Fundación Jiménez Díaz - quirónsalud, Universidad Autónoma de Madrid, Madrid, Spain.
authors: Miguel Angel
authors: MA
authors: Navas
authors: Hospital Universitario Fundación Jiménez Díaz - quirónsalud, Universidad Autónoma de Madrid, Madrid, Spain.
authors: Rosa María
authors: RM
authors: Rábago
authors: Hospital Universitario Fundación Jiménez Díaz - quirónsalud, Universidad Autónoma de Madrid, Madrid, Spain.
authors: Maria Esther
authors: ME
authors: Martínez
authors: Hospital Universitario Fundación Jiménez Díaz - quirónsalud, Universidad Autónoma de Madrid, Madrid, Spain.
authors: Mikel
authors: M
authors: Taibo
authors: Hospital Universitario Fundación Jiménez Díaz - quirónsalud, Universidad Autónoma de Madrid, Madrid, Spain.
authors: Julia
authors: J
authors: Palfy
authors: Hospital Universitario Fundación Jiménez Díaz - quirónsalud, Universidad Autónoma de Madrid, Madrid, Spain.
authors: Manuel
authors: M
authors: Rey
authors: Hospital Universitario Fundación Jiménez Díaz - quirónsalud, Universidad Autónoma de Madrid, Madrid, Spain.
authors: Jerónimo
authors: J
authors: Farré
mesh_terms: D000328:Adult; D000368:Aged; D003937:Diagnosis, Differential; D004452:Echocardiography / Q000379:methods*; D005260:Female; D006801:Humans; D056830:Isolated Noncompaction of the Ventricular Myocardium / Q000000981:diagnostic imaging* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged
keywords: Cardiomyopathy; Non-compaction; Rotation; Speckle tracking