title: Microwave-assisted Synthesis of 2-Styrylquinoline-4-carboxylic Acids as Antitubercular Agents.
abstract: BACKGROUND
  Many 2-substituted quinolines and especially 2-arylvinyl derivatives isolated from plants or prepared by synthesis have been designed from ethnopharmacological studies.
  
  
  OBJECTIVE
  In order to explore new aspects of the structure-antituberculosis activity relationship, a series of styrylquinoline derivatives was prepared.
  
  
  METHODS
  A series of styrylquinoline derivatives was prepared from quinaldic acid and a variety of arylbenzaldehydes under eco-friendly conditions via Knoevenagel reaction and trifluoroacetic acid (TFA) as catalyst.
  
  
  RESULTS
  The products were obtained in short reaction times and good yields and were evaluated for growth inhibitory activity towards Mycobacterium tuberculosis H37Rv (Mtb) through the National Institute of Allergy and Infectious Diseases (NIAID, USA).
  
  
  CONCLUSIONS
  Three compounds had activity under aerobic conditions.
authors: Facultad de Farmacia y Bioquímica, Departamento de Química Orgánica, Universidad de Buenos Aires, Junín 956, C1113AAB Ciudad Autónoma de Buenos Aires, Argentina.
authors: Gisela C
authors: GC
authors: Muscia
authors: Facultad de Farmacia y Bioquímica, Departamento de Química Orgánica, Universidad de Buenos Aires, Junín 956, C1113AAB Ciudad Autónoma de Buenos Aires, Argentina.
authors: Silvia E
authors: SE
authors: Asis
authors: Facultad de Farmacia y Bioquímica, Departamento de Química Orgánica, Universidad de Buenos Aires, Junín 956, C1113AAB Ciudad Autónoma de Buenos Aires, Argentina.
authors: Graciela Y
authors: GY
authors: Buldain
mesh_terms: D000995:Antitubercular Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D055772:Green Chemistry Technology; D008872:Microwaves; D009169:Mycobacterium tuberculosis / Q000187:drug effects; D011804:Quinolines / Q000138:chemical synthesis / Q000494:pharmacology*; D013237:Stereoisomerism; D013343:Styrenes / Q000138:chemical synthesis / Q000494:pharmacology*
chemical_list: D000995:Antitubercular Agents; D011804:Quinolines; D013343:Styrenes
keywords: Mycobacterium tuberculosis; Synthesis; catalysis; microwave; styrylquinolines; tuberculosis