title: PALME: PAtients Like My gEnome.
abstract: PAtients Like My gEnome (PALME) is a webservice that matches patients based on their genome and healthcare profiles. We support two types of inputs: (1) dual query (a variant + phenotype), and (2) genome sequences. For the first type of queries, we will show the patient profile matching the inputs. For the second type of queries, we will calculate similarity (based on Hamming distance) and show the distribution of phenotypes of similar patients given the input sequences of a target patient. Using the publicly available Personal Genome Project (PGP) dataset, we retrieved 4,360 patients' profiles along with their genome data, medical conditions, and treatments. We used a subset of these profiles to build PALME to be an interactive system to support healthcare profile matching. PALME is designed not only for biomedical researchers to support their studies on human genome but also for individuals to explore their own genetics and health. The webservice is accessible at (http://pgp.ucsd-dbmi.org:3838/GenAnaly/PatientGen/#) and the demo videos are available at (https://youtu.be/ycP0rXQizlc).
authors: College of Information Engineering, Northwest A&F University, Yangling, Shaanxi, China.
authors: Lichang
authors: L
authors: Wang
authors: College of Information Engineering, Northwest A&F University, Yangling, Shaanxi, China.
authors: Yong
authors: Y
authors: Fang
authors: New Jersey Institute of Technology, Newark, New Jersey.
authors: Dima
authors: D
authors: Aref
authors: Electrical Engineering & Computer Science, Syracuse University, Syracuse, New York.
authors: Suyash
authors: S
authors: Rathi
authors: Institute of Biological Sciences and Biotechnology, Donghua University, Shanghai, China;
authors: Li
authors: L
authors: Shen
authors: Department of Biomedical Informatics, University of California San Diego, La Jolla, California.
authors: Xiaoqian
authors: X
authors: Jiang
authors: Department of Biomedical Informatics, University of California San Diego, La Jolla, California.
authors: Shuang
authors: S
authors: Wang