title: Synthesis and preliminary evaluation of dimeric-28-homobrassinosteroids for plant growth regulators.
abstract: Preparation of synthetic analogues of 28-homobrassinosteroids is reported. Also, the addition of the 28-homocastasterone at the C6 carbonyl group via allyl Gringard reagent followed by olefin cross metathesis resulted in dimeric analogues. Rice lamina inclination assay showed that the replacement of the C6 carbonyl group by 6α-allyl and 6β hydroxyl groups led to a decrease in bioactivity, whereas the dimeric analogues showed a reduced but significant bioactivity when compared to the 28-homocastasterone.
authors: Department of Chemistry, Faculty of Science, Silpakorn University, Nakorn Pathom 73000, Thailand.
authors: Waya S
authors: WS
authors: Phutdhawong
authors: Bioproduct Science Program, Department of Science, Faculty of Liberal Arts and Science, Kasetsart University, Kampang Saen Campus, Nakhon Pathom 73140, Thailand.
authors: Wanwikar
authors: W
authors: Ruensamran
authors: Bioproduct Science Program, Department of Science, Faculty of Liberal Arts and Science, Kasetsart University, Kampang Saen Campus, Nakhon Pathom 73140, Thailand; Department of Chemistry, Faculty of Liberal Arts and Science, Kasetsart University Kampang Saen Campus, Nakhon Pathom 73140, Thailand. Electronic address: faaswcp@ku.ac.th.
authors: Weerachai
authors: W
authors: Phutdhawong
mesh_terms: D060406:Brassinosteroids / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D002778:Cholestanones / Q000737:chemistry; D019281:Dimerization; D012275:Oryza / Q000187:drug effects / Q000254:growth & development; D010937:Plant Growth Regulators / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D060406:Brassinosteroids; D002778:Cholestanones; D010937:Plant Growth Regulators; C070164:homocastasterone
keywords: 28-Homocastasterone; 6α-Allyl-6β hydroxyl homocastasterone; Brassinosteroids; Dimerization; Plant growth promoting activity; Rice lamination inclination