title: Quercetin-Decorated Curcumin Liposome Design for Cancer Therapy: In-Vitro and In-Vivo Studies.
abstract: BACKGROUND
  Curcumin is a yellow polyphenolic chemopreventive agent isolated from the rhizomes of Curcuma longa. It is approved as Generally Regarded as Safe by US FDA. Nonetheless, its clinical success is limited due to its poor aqueous solubility, fast metabolism and short biological half-life attributes.
  
  
  OBJECTIVE
  Quercetin-decorated liposomes of curcumin (QCunp) are perceived to be able to overcome these biopharmaceutical drawbacks.
  
  
  METHODS
  Curcumin liposomes with/without quercetin were prepared by lipid hydration technique. The liposomes were characterized for their particle size, zeta potential, surface morphology, drug loading and release characteristics. The toxicity of the liposomes were evaluated in-vitro and their invivo efficacy were tested against Dalton's ascites lymphoma in mice.
  
  
  RESULTS
  Liposomes designed showed particle size of 261.8 ± 2.1 nm with a negative zeta potential of -22.6±1.6 mV. Quercetin decorated liposomes were more effective in increasing the life span and body weight of lymphoma inflicted mice compared to those without quercetin. Similarly, the presence of quercetin also contributed to enhanced cytotoxicity of the liposomal formulation towards HT-29 cells and HCT-15 cells.
  
  
  CONCLUSIONS
  Newer liposomal design exhibited promising potential to emerge as alternative anticancer therapeutics.
authors: National Institute of Pharmaceutical Education and Research, Kolkata. India.
authors: V
authors: V
authors: Ravichandiran
authors: Faculty of Engineering Technology (Pharmaceutical), University Malaysia Pahang, Gambang-26300, Kuantan. Malaysia.
authors: K
authors: K
authors: Masilamani
authors: Jaya College of Paramedical Sciences, CTH Road, Thiruninravur, Chennai--602 024, Tamil Nadu. India.
authors: B
authors: B
authors: Senthilnathan
authors: CARISM Sastra University, Thanjavur, Tamilnadu. India.
authors: A
authors: A
authors: Maheshwaran
authors: Non-Destructive Biomedical and Pharmaceutical Research Centre, iPROMISE, Universiti Teknologi MARA, Puncak Alam, 42300, Selangor. Malaysia.
authors: Tin Wui
authors: TW
authors: Wong
authors: Department of Pharmaceutical Technology, Adamas University, Kolkata. India.
authors: Partha
authors: P
authors: Roy
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000737:chemistry* / Q000494:pharmacology / Q000627:therapeutic use; D049109:Cell Proliferation / Q000187:drug effects; D003474:Curcumin / Q000008:administration & dosage* / Q000737:chemistry* / Q000494:pharmacology / Q000627:therapeutic use; D004354:Drug Screening Assays, Antitumor; D019073:HT29 Cells; D006801:Humans; D008081:Liposomes / Q000008:administration & dosage / Q000138:chemical synthesis / Q000737:chemistry*; D008223:Lymphoma / Q000188:drug therapy* / Q000473:pathology; D008297:Male; D051379:Mice; D009374:Neoplasms, Experimental / Q000188:drug therapy / Q000473:pathology; D010316:Particle Size; D011794:Quercetin / Q000008:administration & dosage / Q000737:chemistry*; D013499:Surface Properties; D014407:Tumor Cells, Cultured
chemical_list: D000970:Antineoplastic Agents; D008081:Liposomes; D011794:Quercetin; D003474:Curcumin
keywords: Curcumin; Dalton's ascites lymphoma; cancer; cytotoxicity; liposomes; quercetin