title: Heterocyclic Compounds: Effective α-Amylase and α-Glucosidase Inhibitors.
abstract: Diabetes Mellitus (DM) is a metabolic disease characterized by high blood sugar levels. Recently, it has emerged as an important and global health problem with long-term complications and high economic burden. α-Amylase (α-Amy) and α-glucosidase (α-Gls) are two enzymes which are involved in the hydrolysis of starch into sugars and disaccharides leading to the increase of blood glucose level. Hence, inhibition of α-amylase and α-glucosidase plays key role in the treatment of type 2 diabetes. Heterocyclic compounds -both synthetic and naturally occurring derivatives- possess efficient biological properties. At this juncture, they have demonstrated potent inhibitory activity against α-Amy and α-Gls and were found to be versatile tools for the development of novel anti-diabetic agents.
authors: Mina
authors: M
authors: Saeedi
authors: Abbas
authors: A
authors: Hadjiakhondi
authors: Seyed Mohammad
authors: SM
authors: Nabavi
authors: Medicinal Plants Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.
authors: Azadeh
authors: A
authors: Manayi
mesh_terms: D004791:Enzyme Inhibitors / Q000494:pharmacology*; D065089:Glycoside Hydrolase Inhibitors / Q000494:pharmacology*; D006571:Heterocyclic Compounds / Q000494:pharmacology*; D000516:alpha-Amylases / Q000037:antagonists & inhibitors*
chemical_list: D004791:Enzyme Inhibitors; D065089:Glycoside Hydrolase Inhibitors; D006571:Heterocyclic Compounds; D000516:alpha-Amylases