title: Blunted renal vasoconstriction in patients with subclinical contrast-induced renal injury.
abstract: Contrast media are considered to cause acute kidney injury by activating various factors that induce renal vasoconstriction. We analysed the renal microvascular haemodynamic response using the Doppler flow wire method. Then changes in urinary liver-type fatty acid-binding protein levels following contrast medium administration were compared between groups with or without a micro-injury of the kidney. In the group without renal micro-injury, the average peak velocity (APV) decreased significantly, whereas the renal artery resistance index (RI) increased significantly following contrast medium administration. In contrast, there was no significant change in either the APV or RI in the group with a renal micro-injury. A blunted microvascular response was found in the micro-injury group, whereas microvascular resistance increased in the non-micro-injury group.
authors: Cardiovascular Centre, Nippon Medical School Chiba Hokusoh Hospital, Chiba, Japan. kurihara-1980@nms.ac.jp.
authors: Osamu
authors: O
authors: Kurihara
authors: Cardiovascular Centre, Nippon Medical School Chiba Hokusoh Hospital, Chiba, Japan.
authors: Yoshihiko
authors: Y
authors: Seino
authors: Cardiovascular Centre, Nippon Medical School Chiba Hokusoh Hospital, Chiba, Japan.
authors: Yusaku
authors: Y
authors: Shibata
authors: Cardiovascular Centre, Nippon Medical School Chiba Hokusoh Hospital, Chiba, Japan.
authors: Masato
authors: M
authors: Matsushita
authors: Cardiovascular Centre, Nippon Medical School Chiba Hokusoh Hospital, Chiba, Japan.
authors: Hidenori
authors: H
authors: Komiyama
authors: Cardiovascular Centre, Nippon Medical School Chiba Hokusoh Hospital, Chiba, Japan.
authors: Katsuhito
authors: K
authors: Kato
authors: Cardiovascular Centre, Nippon Medical School Chiba Hokusoh Hospital, Chiba, Japan.
authors: Daisuke
authors: D
authors: Murakami
authors: Cardiovascular Centre, Nippon Medical School Chiba Hokusoh Hospital, Chiba, Japan.
authors: Ryo
authors: R
authors: Munakata
authors: Cardiovascular Centre, Nippon Medical School Chiba Hokusoh Hospital, Chiba, Japan.
authors: Masamichi
authors: M
authors: Takano
authors: Cardiovascular Centre, Nippon Medical School Chiba Hokusoh Hospital, Chiba, Japan.
authors: Yasushi
authors: Y
authors: Miyauchi
authors: Cardiovascular Centre, Nippon Medical School Chiba Hokusoh Hospital, Chiba, Japan.
authors: Noritake
authors: N
authors: Hata
authors: Department of Cardiovascular Medicine, Nippon Medical School, Tokyo, Japan.
authors: Wataru
authors: W
authors: Shimizu
mesh_terms: D058186:Acute Kidney Injury / Q000139:chemically induced* / Q000000981:diagnostic imaging*; D000368:Aged; D000369:Aged, 80 and over; D003287:Contrast Media / Q000009:adverse effects*; D017023:Coronary Angiography / Q000009:adverse effects; D005260:Female; D006801:Humans; D007668:Kidney / Q000098:blood supply / Q000000981:diagnostic imaging / Q000187:drug effects; D008297:Male; D008875:Middle Aged; D014661:Vasoconstriction / Q000187:drug effects* / Q000502:physiology
chemical_list: D003287:Contrast Media
keywords: acute kidney injury; contrast media; haemodynamics