title: Longitudinal changes in maternal serum concentrations of antimüllerian hormone in individual women during conception cycles and early pregnancy.
abstract: OBJECTIVE
  To study antimüllerian hormone (AMH) from gestation week 0-7.
  
  
  METHODS
  Longitudinal study of 85 pregnant women with AMH and reproductive hormones sampled during conception cycle and early pregnancy until week 7.
  
  
  METHODS
  Fertility clinic.
  
  
  METHODS
  Of 85 pregnant women, 69 had a singleton pregnancy, 1 a twin pregnancy, and 15 had a nonviable pregnancy (3 chemical pregnancies, 11 miscarriages, and 1 blighted ovum).
  
  
  METHODS
  None.
  
  
  METHODS
  Relationship between AMH and gestation week, woman's age, body mass index (BMI), FSH dose, treatment modality, reproductive hormones, viability of pregnancies, and fetal gender.
  
  
  RESULTS
  During the conception cycle, 86.1% of women had their maximum AMH at or before ovulation. The AMH level did not remain constant in viable pregnancies, but moved significantly away from baseline pregnancy level. In natural pregnancies the overall trend was for decreasing AMH level. In treatment pregnancies AMH level either consistently increased or decreased from gestation week 4 (time of first positive hCG) through to week 7. In contrast, the AMH level in nonviable pregnancies showed sporadic changes, both increasing and decreasing in the same individual from gestation weeks 4-7. The AMH level was negatively correlated with patient's age (r = -0.507) and P level (r = -0.220), but no other associations were observed with BMI, FSH dose, treatment modality, or fetal gender.
  
  
  CONCLUSIONS
  The AMH level peaked at or before ovulation in most women, trended down with natural pregnancies, and consistently increased or decreased in women with a viable pregnancy after therapy. Nonviable pregnancies showed erratic AMH patterns. Factors responsible for these different responses in pregnancy remain to be identified.
authors: Fertility North, Joondalup Private Hospital, Edith Cowan University, Joondalup, Western Australia, Australia; School of Medical and Health Sciences, Edith Cowan University, Joondalup, Western Australia, Australia.
authors: Kristina
authors: K
authors: Hamilton
authors: Biochemistry Department, Sir Charles Gairdner Hospital, Nedlands, Western Australia, Australia; School of Laboratory Medicine, University of Western Australia, Nedlands, Western Australia, Australia.
authors: Narelle
authors: N
authors: Hadlow
authors: School of Medical and Health Sciences, Edith Cowan University, Joondalup, Western Australia, Australia.
authors: Peter
authors: P
authors: Roberts
authors: Fertility North, Joondalup Private Hospital, Edith Cowan University, Joondalup, Western Australia, Australia.
authors: Patricia
authors: P
authors: Sykes
authors: Fertility North, Joondalup Private Hospital, Edith Cowan University, Joondalup, Western Australia, Australia.
authors: Allison
authors: A
authors: McClements
authors: Research Consultant (Statistics), Edith Cowan University, Joondalup, Western Australia, Australia.
authors: Jacqui
authors: J
authors: Coombes
authors: Fertility North, Joondalup Private Hospital, Edith Cowan University, Joondalup, Western Australia, Australia; School of Medical and Health Sciences, Edith Cowan University, Joondalup, Western Australia, Australia. Electronic address: phill.matson@fertilitynorth.com.au.
authors: Phillip
authors: P
authors: Matson
mesh_terms: D000022:Abortion, Spontaneous / Q000097:blood / Q000000981:diagnostic imaging / Q000209:etiology; D000328:Adult; D054304:Anti-Mullerian Hormone / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D005260:Female; D005300:Fertility Agents, Female / Q000008:administration & dosage; D005306:Fertilization / Q000187:drug effects; D005640:Follicle Stimulating Hormone / Q000008:administration & dosage; D006801:Humans; D007247:Infertility, Female / Q000097:blood* / Q000175:diagnosis / Q000503:physiopathology / Q000628:therapy; D008137:Longitudinal Studies; D008297:Male; D010060:Ovulation / Q000187:drug effects; D011247:Pregnancy; D011261:Pregnancy Trimester, First / Q000097:blood*; D059285:Pregnancy, Twin / Q000097:blood; D027724:Reproductive Techniques, Assisted; D012732:Sex Determination Analysis; D013997:Time Factors; D016216:Ultrasonography, Prenatal
chemical_list: D015415:Biomarkers; D005300:Fertility Agents, Female; D054304:Anti-Mullerian Hormone; D005640:Follicle Stimulating Hormone
keywords: AMH; conception cycle; early pregnancy