title: Recovery of endocochlear potential after severe damage to lateral wall fibrocytes following acute cochlear energy failure.
abstract: Reduction of endocochlear potential (EP) is one of the main causes of sensorineural hearing loss. In this study, we investigated changes in the EP using a mouse model of acute cochlear energy failure, which comprised severe cochlear lateral wall damage induced by the local administration of 3-nitropropionic acid to the inner ear. We also analyzed the correlation between EP changes and histological findings in the cochlear lateral wall. We detected the recovery of the EP and hearing function at lower frequencies after severe damage of the cochlear lateral wall fibrocytes at the corresponding region. Remodeling of the cochlear lateral wall was associated with EP recovery, including the re-expression of ion transporters or gap junctions (i.e. Na/K/ATPase-β1 and connexin 26). These results indicate a mechanism for late-phase hearing recovery after severe deafness, which is frequently observed in clinical settings.
authors: aDivision of Research for Hearing and Balance Disorders, National Institute for Sensory Organs, National Tokyo Medical Center, Tokyo bDepartment of Otolaryngology-Head and Neck Surgery, Hokkaido University Graduate School of Medicine, Hokkaido cDepartment of Otolaryngology-Head and Neck Surgery, National Defense Medical College, Saitama, Japan.
authors: Kyoko
authors: K
authors: Kitao
authors: Kunio
authors: K
authors: Mizutari
authors: Susumu
authors: S
authors: Nakagawa
authors: Tatsuo
authors: T
authors: Matsunaga
authors: Satoshi
authors: S
authors: Fukuda
authors: Masato
authors: M
authors: Fujii
mesh_terms: D000818:Animals; D015834:Cochlear Diseases / Q000139:chemically induced / Q000473:pathology* / Q000503:physiopathology*; D000072259:Connexin 26 / Q000378:metabolism; D004195:Disease Models, Animal; D004569:Electroencephalography; D016057:Evoked Potentials, Auditory, Brain Stem / Q000502:physiology*; D006198:Hair Cells, Auditory / Q000473:pathology; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D009574:Nitro Compounds / Q000633:toxicity; D011422:Propionates / Q000633:toxicity; D020127:Recovery of Function / Q000187:drug effects / Q000502:physiology*; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism; D013136:Spiral Ganglion / Q000187:drug effects / Q000473:pathology; D013997:Time Factors
chemical_list: D009574:Nitro Compounds; D011422:Propionates; D000072259:Connexin 26; D000254:Sodium-Potassium-Exchanging ATPase; C015392:3-nitropropionic acid