title: Association between diabetes and risk of suicide death: A meta-analysis of 3 million participants.
abstract: Results of the relationships between diabetes and the risk of suicide death are inconclusive. This meta-analysis was conducted to assess this association.
  
  
  
  We systematically searched PubMed, EMBASE, Web of Science and the Cochrane Library up to February 29, 2016 for relevant observational studies regarding the association between diabetes and risk of suicide. Random-effects models were used to calculate summary relative risk (RR) and 95% confidence interval (CI).
  
  
  
  6 observational studies (8 independent reports) with a total of 3,075,214 participants and 3038 suicide deaths events were included in the meta-analysis. Overall, diabetes was not associated with risk of suicide deaths, with significant heterogeneity among studies observed (Summary RR=1.61, 95% CI: 0.91-2.83, Pheterogeneity<0.001, I2=97.2%). No publication bias was detected across studies, and both the subgroup analysis and sensitivity analysis suggested that the general result was robust.
  
  
  
  Our meta-analysis based on more than 3 million participants indicates that diabetes is not associated with increased risk of suicide death. Further well-designed prospective cohort studies are needed to confirm the findings of this meta-analysis.
authors: Mental Health Center, Renmin Hospital of Wuhan University, Jiefang Road 238#, Wuchang District, Wuhan 430060, PR China; Hubei Provincial Mental Health Center, Jiefang Road 238#, Wuchang District, Wuhan 430060, PR China.
authors: Ying
authors: Y
authors: Wang
authors: Mental Health Center, Renmin Hospital of Wuhan University, Jiefang Road 238#, Wuchang District, Wuhan 430060, PR China; Hubei Provincial Mental Health Center, Jiefang Road 238#, Wuchang District, Wuhan 430060, PR China.
authors: Shiming
authors: S
authors: Tang
authors: Mental Health Center, Renmin Hospital of Wuhan University, Jiefang Road 238#, Wuchang District, Wuhan 430060, PR China; Hubei Provincial Mental Health Center, Jiefang Road 238#, Wuchang District, Wuhan 430060, PR China.
authors: Shunsheng
authors: S
authors: Xu
authors: Mental Health Center, Renmin Hospital of Wuhan University, Jiefang Road 238#, Wuchang District, Wuhan 430060, PR China; Hubei Provincial Mental Health Center, Jiefang Road 238#, Wuchang District, Wuhan 430060, PR China.
authors: Shenhong
authors: S
authors: Weng
authors: Mental Health Center, Renmin Hospital of Wuhan University, Jiefang Road 238#, Wuchang District, Wuhan 430060, PR China; Hubei Provincial Mental Health Center, Jiefang Road 238#, Wuchang District, Wuhan 430060, PR China; Department of Psychiatry, Institution of Neuropsychiatry Research, Renmin Hospital of Wuhan University, Jiefang Road 238#, Wuchang District, Wuhan 430060, PR China. Electronic address: zcliu6@whu.edu.cn.
authors: Zhongchun
authors: Z
authors: Liu
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D003920:Diabetes Mellitus / Q000523:psychology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012306:Risk; D013405:Suicide / Q000706:statistics & numerical data*; D055815:Young Adult