title: A new phthalide derivative from Peperomia nivalis.
abstract: One new phthalide (1) was isolated from aerial parts of Peperomia nivalis, along with known compounds (2 and 3), reported in this species for the first time. The structure of the new compound was characterised on the basis of 1D (1H and13C NMR), 2D (COSY, HMQC, HMBC and NOESY) NMR and high-resolution mass spectral (HRMS) data. Compound 2 was isolated from a natural source for the first time but previously synthesised. Compounds 1-3 were evaluated for their anti-Helicobacter pylori and anti-Plasmodium falciparum activities. Compound 1 showed moderate activities against H. pylori (MIC 47.5 μM) and the F32-Tanzania strain of P. falciparum (IC508.5 μM). Compounds 2 and 3 exhibited weak anti-H. pylori activity (MIC 241.3 and 237.6 μM, respectively) and were inactive against P. falciparum.
authors: a Laboratorios de Investigación y Desarrollo, Facultad de Ciencias y Filosofía , Universidad Peruana Cayetano Heredia , Lima , Peru.
authors: Pedro
authors: P
authors: Vásquez-Ocmín
authors: b UMR 152 Pharma Dev , Université de Toulouse, IRD, UPS , Toulouse , France.
authors: Mohamed
authors: M
authors: Haddad
authors: a Laboratorios de Investigación y Desarrollo, Facultad de Ciencias y Filosofía , Universidad Peruana Cayetano Heredia , Lima , Peru.
authors: Alice
authors: A
authors: Gadea
authors: b UMR 152 Pharma Dev , Université de Toulouse, IRD, UPS , Toulouse , France.
authors: Valérie
authors: V
authors: Jullian
authors: a Laboratorios de Investigación y Desarrollo, Facultad de Ciencias y Filosofía , Universidad Peruana Cayetano Heredia , Lima , Peru.
authors: Denis
authors: D
authors: Castillo
authors: c CNRS, LCC (Laboratoire de Chimie de Coordination) UPR8241 , Toulouse , France.|d Université de Toulouse , Toulouse , France.
authors: Lucie
authors: L
authors: Paloque
authors: a Laboratorios de Investigación y Desarrollo, Facultad de Ciencias y Filosofía , Universidad Peruana Cayetano Heredia , Lima , Peru.
authors: Juan Pablo
authors: JP
authors: Cerapio
authors: b UMR 152 Pharma Dev , Université de Toulouse, IRD, UPS , Toulouse , France.
authors: Geneviève
authors: G
authors: Bourdy
authors: b UMR 152 Pharma Dev , Université de Toulouse, IRD, UPS , Toulouse , France.
authors: Michel
authors: M
authors: Sauvain
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology; D000962:Antimalarials / Q000737:chemistry / Q000494:pharmacology; D001572:Benzofurans / Q000737:chemistry* / Q000494:pharmacology*; D016480:Helicobacter pylori / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D036941:Peperomia / Q000737:chemistry*; D010568:Peru; D010963:Plasmodium falciparum / Q000187:drug effects; D013056:Spectrophotometry, Ultraviolet
chemical_list: D000900:Anti-Bacterial Agents; D000962:Antimalarials; D001572:Benzofurans; C082022:phthalide
keywords: Helicobacter pylori; NMR; Peperomia nivalis; Plasmodium; phthalide; secondary metabolites