title: Plasticity of Cell Migration In Vivo and In Silico.
abstract: Cell migration results from stepwise mechanical and chemical interactions between cells and their extracellular environment. Mechanistic principles that determine single-cell and collective migration modes and their interconversions depend upon the polarization, adhesion, deformability, contractility, and proteolytic ability of cells. Cellular determinants of cell migration respond to extracellular cues, including tissue composition, topography, alignment, and tissue-associated growth factors and cytokines. Both cellular determinants and tissue determinants are interdependent; undergo reciprocal adjustment; and jointly impact cell decision making, navigation, and migration outcome in complex environments. We here review the variability, decision making, and adaptation of cell migration approached by live-cell, in vivo, and in silico strategies, with a focus on cell movements in morphogenesis, repair, immune surveillance, and cancer metastasis.
authors: David H. Koch Center for Applied Research of Genitourinary Cancers, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030; email: PFriedl@mdanderson.org.
authors: Veronika
authors: V
authors: Te Boekhorst
authors: Department of Mathematical Sciences, Politecnico di Torino, 10129 Torino, Italy.
authors: Luigi
authors: L
authors: Preziosi
authors: David H. Koch Center for Applied Research of Genitourinary Cancers, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030; email: PFriedl@mdanderson.org.|Department of Cell Biology, Radboud University Medical Centre, 6525GA Nijmegen, The Netherlands; email: Peter.Friedl@radboudumc.nl.|Cancer Genomics Center, 3584 CG Utrecht, The Netherlands.
authors: Peter
authors: P
authors: Friedl
mesh_terms: D000818:Animals; D002465:Cell Movement; D000066670:Cell Plasticity; D003198:Computer Simulation; D006801:Humans; D008954:Models, Biological
keywords: amoeboid migration; cell adhesion; collective movement; mathematical modeling; mesenchymal migration; proteolysis