title: A One Health overview, facilitating advances in comparative medicine and translational research.
abstract: A1 One health advances and successes in comparative medicine and translational researchCheryl StroudA2 Dendritic cell-targeted gorilla adenoviral vector for cancer vaccination for canine melanomaIgor Dmitriev, Elena Kashentseva, Jeffrey N. Bryan, David T. CurielA3 Viroimmunotherapy for malignant melanoma in the companion dog modelJeffrey N. Bryan, David Curiel, Igor Dmitriev, Elena Kashentseva, Hans Rindt, Carol Reinero, Carolyn J. HenryA4 Of mice and men (and dogs!): development of a commercially licensed xenogeneic DNA vaccine for companion animals with malignant melanomaPhilip J. BergmanA5 Successful immunotherapy with a recombinant HER2-expressing Listeria monocytogenes in dogs with spontaneous osteosarcoma paves the way for advances in pediatric osteosarcomaNicola J. Mason, Josephine S. Gnanandarajah, Julie B. Engiles, Falon Gray, Danielle Laughlin, Anita Gaurnier-Hausser, Anu Wallecha, Margie Huebner, Yvonne PatersonA6 Human clinical development of ADXS-HER2Daniel O'ConnorA7 Leveraging use of data for both human and veterinary benefitLaura S. TremlA8 Biologic replacement of the knee: innovations and early clinical resultsJames P. StannardA9 Mizzou BioJoint Center: a translational success storyJames L. CookA10 University and industry translational partnership: from the lab to commercializationMarc JacobsA11 Beyond docking: an evolutionarily guided OneHealth approach to drug discoveryGerald J. Wyckoff, Lee Likins, Ubadah Sabbagh, Andrew SkaffA12 Challenges and opportunities for data applications in animal health: from precision medicine to precision husbandryAmado S. GuloyA13 A cloud-based programmable platform for healthHarlen D. HaysA14 Comparative oncology: One Health in actionAmy K. LeBlancA15 Companion animal diseases bridge the translational gap for human neurodegenerative diseaseJoan R. Coates, Martin L. Katz, Leslie A. Lyons, Gayle C. Johnson, Gary S. Johnson, Dennis P. O'BrienA16 Duchenne muscular dystrophy gene therapyDongsheng DuanA17 Polycystic kidney disease: cellular mechanisms to emerging therapiesJames P. CalvetA18 The domestic cat as a large animal model for polycystic kidney diseaseLeslie A. Lyons, Barbara GandolfiA19 The support of basic and clinical research by the Polycystic Kidney Disease FoundationDavid A. BaronA20 Using naturally occurring large animal models of human disease to enable clinical translation: treatment of arthritis using autologous stromal vascular fraction in dogsMark L. WeissA21 Regulatory requirements regarding clinical use of human cells, tissues, and tissue-based productsDebra A. WebsterA22 Regenerative medicine approaches to Type 1 diabetes treatmentFrancis N. KaranuA23 The zoobiquity of canine diabetes mellitus, man's best friend is a friend indeed-islet transplantationEdward J. RobbA24 One Medicine: a development model for cellular therapy of diabetesRobert J. Harman.
authors: One Health Commission, Apex, NC, 27502, USA. cstroud@onehealthcommission.org.
authors: Cheryl
authors: C
authors: Stroud
authors: Biologic Therapeutics Center, Washington University in St. Louis, St. Louis, MO, 63130, USA.
authors: Igor
authors: I
authors: Dmitriev
authors: Biologic Therapeutics Center, Washington University in St. Louis, St. Louis, MO, 63130, USA.
authors: Elena
authors: E
authors: Kashentseva
authors: Comparative Oncology, Radiobiology, and Epigenetics Laboratory, University of Missouri, Columbia, MO, 65203, USA.|Comparative Oncology, Radiobiology, and Epigenetics Laboratory, University of Missouri, Columbia, MO, 65211, USA.
authors: Jeffrey N
authors: JN
authors: Bryan
authors: Biologic Therapeutics Center, Washington University in St. Louis, St. Louis, MO, 63130, USA.
authors: David T
authors: DT
authors: Curiel
authors: Comparative Oncology, Radiobiology, and Epigenetics Laboratory, University of Missouri, Columbia, MO, 65211, USA.|Comparative Internal Medicine Laboratory, University of Missouri, Columbia, MO, 65203, USA.
authors: Hans
authors: H
authors: Rindt
authors: Comparative Internal Medicine Laboratory, University of Missouri, Columbia, MO, 65203, USA.
authors: Carol
authors: C
authors: Reinero
authors: Comparative Oncology, Radiobiology, and Epigenetics Laboratory, University of Missouri, Columbia, MO, 65211, USA.
authors: Carolyn J
authors: CJ
authors: Henry
authors: Katonah Bedford Veterinary Center, Bedford Hills, NY, 10507, USA.|Clinical Studies Division, VCA, Los Angeles, CA, 90064, USA.|Adjunct Associate Faculty, Memorial Sloan-Kettering Cancer Center, New York City, NY, 10065, USA.
authors: Philip J
authors: PJ
authors: Bergman
authors: University of Pennsylvania School of Veterinary Medicine, 3900 Delancey Street, Philadelphia, PA, 19104, USA.
authors: Nicola J
authors: NJ
authors: Mason
authors: University of Pennsylvania School of Veterinary Medicine, 3900 Delancey Street, Philadelphia, PA, 19104, USA.
authors: Josephine S
authors: JS
authors: Gnanandarajah
authors: University of Pennsylvania School of Veterinary Medicine, 3900 Delancey Street, Philadelphia, PA, 19104, USA.
authors: Julie B
authors: JB
authors: Engiles
authors: University of Pennsylvania School of Veterinary Medicine, 3900 Delancey Street, Philadelphia, PA, 19104, USA.
authors: Falon
authors: F
authors: Gray
authors: University of Pennsylvania School of Veterinary Medicine, 3900 Delancey Street, Philadelphia, PA, 19104, USA.
authors: Danielle
authors: D
authors: Laughlin
authors: Office of Professional Studies in the Health Sciences, Drexel University College of Medicine, Room 4801 New College Building, 245 North 15th Street, Philadelphia, PA, 19102, USA.
authors: Anita
authors: A
authors: Gaurnier-Hausser
authors: Advaxis Immunotherapies Inc., 305 College Road East, Princeton, NJ, 08540, USA.
authors: Anu
authors: A
authors: Wallecha
authors: ClinData Services Inc., 6713 Holyoke Court, Fort Collins, CO, 80525, USA.
authors: Margie
authors: M
authors: Huebner
authors: Department of Microbiology, University of Pennsylvania Perelman School of Medicine, 319A Johnson Pavilion, 3610 Hamilton Walk, Philadelphia, PA, 19104, USA.
authors: Yvonne
authors: Y
authors: Paterson
authors: Advaxis Immunotherapies Inc., 305 College Road East, Princeton, NJ, 08540, USA.
authors: Daniel
authors: D
authors: O'Connor
authors: Aratana Therapeutics Inc., Leawood, KS, 66211, USA.
authors: Laura S
authors: LS
authors: Treml
authors: Department of Orthopaedic Surgery, Missouri Orthopaedic Institute, 1100 Virginia Ave., Columbia, MO, 65212, USA. stannardj@health.missouri.edu.
authors: James P
authors: JP
authors: Stannard
authors: Comparative Orthopaedic Lab, Mizzou BioJoint Center, Missouri Orthopaedic Institute, University of Missouri, Columbia, MO, 65211, USA.
authors: James L
authors: JL
authors: Cook
authors: Musculoskeletal Transplant Foundation (MTF), Edison, NJ, 08837, USA.
authors: Marc
authors: M
authors: Jacobs
authors: Division of Molecular Biology and Biochemistry, School of Biological Sciences, University of Missouri-Kansas City, Kansas City, MO, 64110, USA.
authors: Gerald J
authors: GJ
authors: Wyckoff
authors: Division of Molecular Biology and Biochemistry, School of Biological Sciences, University of Missouri-Kansas City, Kansas City, MO, 64110, USA.
authors: Lee
authors: L
authors: Likins
authors: Division of Molecular Biology and Biochemistry, School of Biological Sciences, University of Missouri-Kansas City, Kansas City, MO, 64110, USA.
authors: Ubadah
authors: U
authors: Sabbagh
authors: Division of Molecular Biology and Biochemistry, School of Biological Sciences, University of Missouri-Kansas City, Kansas City, MO, 64110, USA.
authors: Andrew
authors: A
authors: Skaff
authors: Rex Animal Health, Kansas City, KS, 66103, USA. amado@rexanimalhealth.com.
authors: Amado S
authors: AS
authors: Guloy
authors: Cerner Corporation, Kansas City, MO, 64117, USA.
authors: Harlen D
authors: HD
authors: Hays
authors: Comparative Oncology Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20892, USA.
authors: Amy K
authors: AK
authors: LeBlanc
authors: Departments of Veterinary Medicine and Surgery, University of Missouri, Columbia, MO, 65211, USA. CoatesJ@missouri.edu.
authors: Joan R
authors: JR
authors: Coates
authors: Mason Eye Institute, University of Missouri, Columbia, MO, 65211, USA.
authors: Martin L
authors: ML
authors: Katz
authors: Departments of Veterinary Medicine and Surgery, University of Missouri, Columbia, MO, 65211, USA. lyonsla@missouri.edu.
authors: Leslie A
authors: LA
authors: Lyons
authors: Veterinary Pathobiology, Comparative Neurology Program, University of Missouri, Columbia, MO, 65211, USA.
authors: Gayle C
authors: GC
authors: Johnson
authors: Veterinary Pathobiology, Comparative Neurology Program, University of Missouri, Columbia, MO, 65211, USA.
authors: Gary S
authors: GS
authors: Johnson
authors: Departments of Veterinary Medicine and Surgery, University of Missouri, Columbia, MO, 65211, USA.
authors: Dennis P
authors: DP
authors: O'Brien
authors: Department of Molecular Microbiology and Immunology, Department of Neurology, Department of Bioengineering, University of Missouri, Columbia, MO, 65212, USA.
authors: Dongsheng
authors: D
authors: Duan
authors: Kidney Institute, University of Kansas Medical Center, Kansas City, KS, 66160, USA.
authors: James P
authors: JP
authors: Calvet
authors: Departments of Veterinary Medicine and Surgery, University of Missouri, Columbia, MO, 65211, USA.
authors: Barbara
authors: B
authors: Gandolfi
authors: Polycystic Kidney Disease Foundation, Kansas City, MO, 64114, USA. davidb@pkdcure.org.
authors: David A
authors: DA
authors: Baron
authors: Department of Anatomy and Physiology, Kansas State University College of Veterinary Medicine, Manhattan, KS, 66506, USA.
authors: Mark L
authors: ML
authors: Weiss
authors: Cardinal Health Regulatory Sciences, Overland Park, KS, 64078, USA. debra.webster@cardinalhealth.com.
authors: Debra A
authors: DA
authors: Webster
authors: Likarda LLC, Kansas City, KS, 66103, USA. fkaranu@likarda.com.
authors: Francis N
authors: FN
authors: Karanu
authors: Likarda LLC, Kansas City, KS, 66103, USA.
authors: Edward J
authors: EJ
authors: Robb
authors: VetStem Biopharma, Inc., Poway, CA, 92064, USA. bharman@vetstem.com.
authors: Robert J
authors: RJ
authors: Harman