title: Immunoregulatory functions of immune complexes in vaccine and therapy.
abstract: Clinical and experimental preparations of IgG/soluble antigen complexes, as well as those formed following antibody therapy in vivo, are multifaceted immune regulators. These immune complexes (ICs) have been tested in humans and animal models, mostly in forms of experimental or clinical vaccination, for at least a century. With intensified research on Fcγ receptor-mediated immune modulation, as well as with immune complex-directed antigen processing, presentation, and inflammatory responses, there are renewed interests of using ICs in vaccines and immunotherapies. Currently, IC-based immune therapy has been broadly experimented in HBV and HIV viral infection control and antitumor treatments. However, mechanistic insights of IC-based treatments are relatively recent subjects of study; strong efforts are needed to establish links to connect laboratory findings with clinical practices. This review covers the history, mechanisms, and in vivo outcomes of this safe and effective therapeutic tool, with a clear aim to bridge laboratory findings with evolving clinical applications.
authors: Key Laboratory of Molecular Medical Virology, MOE/MOH, School of Basic Medical Sciences Shanghai Medical College Fudan University, Shanghai, China ymwen@shmu.edu.cn yanshi@biomed.tsinghua.edu.cn.
authors: Yu-Mei
authors: YM
authors: Wen
authors: Center for Life Sciences, Department of Basic Medical Sciences, Institute of Immunology Tsinghua University, Beijing, China.
authors: Libing
authors: L
authors: Mu
authors: Center for Life Sciences, Department of Basic Medical Sciences, Institute of Immunology Tsinghua University, Beijing, China Department of Microbiology, Immunology and Infectious Diseases, University of Calgary, Calgary, Canada ymwen@shmu.edu.cn yanshi@biomed.tsinghua.edu.cn.
authors: Yan
authors: 0000-0002-6715-7681
authors: Y
authors: Shi
mesh_terms: D000818:Animals; D000936:Antigen-Antibody Complex / Q000378:metabolism*; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical; D015658:HIV Infections / Q000628:therapy; D019694:Hepatitis B, Chronic / Q000628:therapy; D006801:Humans; D007155:Immunologic Factors / Q000378:metabolism*; D007167:Immunotherapy / Q000379:methods*; D009369:Neoplasms / Q000628:therapy
chemical_list: D000936:Antigen-Antibody Complex; D007155:Immunologic Factors
keywords: FcγR; adjuvant; immune complex; immune therapy; vaccine