title: The beneficial effects of Montelukast against 2,3,7,8-tetrachlorodibenzo- p -dioxin toxicity in female reproductive system in rats.
abstract: OBJECTIVE
  To determine the toxic effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on reproductive system and the beneficial effects of Montelukast (ML) with histological and biochemical analysis.
  
  
  METHODS
  Rats were randomly divided into four equal groups (control, TCDD, ML and TCDD+ML). Tissue samples were collected on day 60 and oxidative status and histological alterations were analyzed.
  
  
  RESULTS
  The results showed a significant increase in oxidative and histological damage on uterine and ovarian tissues. Otherwise, the oxidative and histological damages caused by TCDD were prevented with ML treatment.
  
  
  CONCLUSIONS
  The toxic effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on female reproductive system were reversed with Montelukast treatment. Therefore, we claimed that ML treatment might be useful for TCDD toxicity.
authors: Assistant Professor, Department of Obstetrics and Gynaecology, Faculty of Medicine, University of Inonu, Malatya, Turkey. Acquisition of data, manuscript writing.
authors: Rauf
authors: R
authors: Melekoglu
authors: Associate Professor, Department of Medical Pharmacology, Faculty of Medicine, University of Inonu, Malatya, Turkey. Design of the study, manuscript writing.
authors: Osman
authors: O
authors: Ciftci
authors: Assistant Professor, Department of Histology, Faculty of Medicine, University of Inonu, Malatya, Turkey. Histological examinations.
authors: Aslı
authors: A
authors: Cetin
authors: PhD, Department of Pharmaceutical Toxicology, Faculty of Pharmacy, University of Inonu, Malatya, Turkey. Biochemical examinations.
authors: Nese
authors: N
authors: Basak
authors: Associate Professor, Department of Obstetrics and Gynaecology, Faculty of Medicine, University of Inonu, Malatya, Turkey. Design of the study.
authors: Ebru
authors: E
authors: Celik
mesh_terms: D000085:Acetates / Q000494:pharmacology*; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D002374:Catalase / Q000378:metabolism; D003521:Cyclopropanes; D005260:Female; D005978:Glutathione / Q000378:metabolism; D006080:Ovarian Follicle / Q000187:drug effects; D010053:Ovary / Q000187:drug effects* / Q000473:pathology; D018384:Oxidative Stress / Q000187:drug effects*; D000072317:Polychlorinated Dibenzodioxins / Q000633:toxicity*; D011804:Quinolines / Q000494:pharmacology*; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D013440:Sulfides; D013482:Superoxide Dismutase / Q000378:metabolism; D013723:Teratogens / Q000633:toxicity*; D014599:Uterus / Q000187:drug effects* / Q000473:pathology
chemical_list: D000085:Acetates; D000975:Antioxidants; D003521:Cyclopropanes; D000072317:Polychlorinated Dibenzodioxins; D011804:Quinolines; D013440:Sulfides; D013723:Teratogens; D002374:Catalase; D013482:Superoxide Dismutase; D005978:Glutathione; C093875:montelukast