title: The effect of acute and short term normobaric hyperoxia on hemorheologic parameters.
abstract: Backround:Possible toxic effects of hyperoxia have been reported previously. However, the number of studies investigating the influence of hyperoxia on blood cells is limited and there are no data regarding its hemorheological effects.
  
  
  OBJECTIVE
  The aim of this study was to investigate the effects of acute hyperoxia, performed in human subjects at normal atmospheric pressure, on the rheological properties of blood.
  
  
  METHODS
  The study was conducted with 12 brain death patients mechanically ventilated in the intensive care unit. The patients were ventilated with 21%, 40%, and 100% oxygen before induction of apnea testing performed for diagnosis of brain death. Blood samples were obtained at each oxygen concentration value for all patients.
  
  
  RESULTS
  The results of the study indicated no significant change of red blood cell aggregation, deformability and plasma or whole blood viscosity associated with acute hyperoxia at normobaric conditions.
  
  
  CONCLUSIONS
  The results of the study suggest that application of normobaric hyperoxia does not have detrimental effects on hemorheological parameters in brain death patients, and that organs considered for donation from such subjects are not adversely affected by abnormalities of blood flow and tissue perfusion.
authors: Department of Physiology, Medical Faculty, Akdeniz University, Kampus, 07070, Antalya, Turkey. Tel.: +90 242 2496960; Fax: +90 242 2274483; E-mail: ulkerpinar@akdeniz.edu.tr.
authors: Pinar
authors: P
authors: Ulker
mesh_terms: D001809:Blood Viscosity / Q000502:physiology*; D001926:Brain Death / Q000503:physiopathology*; D001930:Brain Injuries; D004903:Erythrocyte Aggregation / Q000502:physiology*; D004907:Erythrocyte Deformability / Q000502:physiology*; D006801:Humans; D018496:Hyperoxia; D007362:Intensive Care Units; D010100:Oxygen / Q000378:metabolism*; D012212:Rheology
chemical_list: D010100:Oxygen
keywords: Oxygen; erythrocyte; rheology; toxicity