title: Ser/Thr kinases and polyamines in the regulation of non-canonical functions of elongation factor 1A.
abstract: The link between eukaryotic translation elongation factor 1A (eEF1A) and signal transduction pathways through the regulatory mechanism of phosphorylation has never been considered. In this review, we focus on the different kinases that recognize the Ser and Thr residues of the eEF1A1 and eEF1A2 isoforms and regulate their involvement in different cellular processes like cell survival and apoptosis. In this context, polyamines seem to play a role in the regulation of the translation elongation process by modulating the Ser/Thr kinases involved in the phosphorylation of translation elongation factors.
authors: Department of Molecular Medicine and Medical Biotechnology, University of Naples Federico II, Via S. Pansini 5, 8031, Naples, Italy.
authors: Nunzia
authors: N
authors: Migliaccio
authors: Department of Molecular Medicine and Medical Biotechnology, University of Naples Federico II, Via S. Pansini 5, 8031, Naples, Italy.
authors: Nicola M
authors: NM
authors: Martucci
authors: Department of Molecular Medicine and Medical Biotechnology, University of Naples Federico II, Via S. Pansini 5, 8031, Naples, Italy.
authors: Immacolata
authors: I
authors: Ruggiero
authors: ERT, Research Technology GmbH, Sieboldstrasse 3, 97230, Estenfeld, Germany.
authors: Carmen
authors: C
authors: Sanges
authors: Department of Biochemical Sciences "A. Rossi Fanelli", "SAPIENZA" University of Rome, Piazzale Aldo Moro 5, 00185, Rome, Italy.
authors: Shinji
authors: S
authors: Ohkubo
authors: Department of Molecular Medicine and Medical Biotechnology, University of Naples Federico II, Via S. Pansini 5, 8031, Naples, Italy.
authors: Annalisa
authors: A
authors: Lamberti
authors: Department of Biochemical Sciences "A. Rossi Fanelli", "SAPIENZA" University of Rome, Piazzale Aldo Moro 5, 00185, Rome, Italy. enzo.agostinelli@uniroma1.it.
authors: Enzo
authors: E
authors: Agostinelli
authors: Department of Molecular Medicine and Medical Biotechnology, University of Naples Federico II, Via S. Pansini 5, 8031, Naples, Italy. arcari@unina.it.|CEINGE, Advanced Biotechnology Scarl, Via Gaetano Salvatore 486, 80145, Naples, Italy. arcari@unina.it.
authors: Paolo
authors: P
authors: Arcari
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000502:physiology*; D002470:Cell Survival / Q000502:physiology; D006801:Humans; D010441:Peptide Chain Elongation, Translational / Q000502:physiology*; D020648:Peptide Elongation Factor 1 / Q000235:genetics / Q000378:metabolism*; D010766:Phosphorylation / Q000502:physiology; D017346:Protein Serine-Threonine Kinases / Q000235:genetics / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology*
chemical_list: C094814:EEF1A1 protein, human; C503234:EEF1A2 protein, human; D020648:Peptide Elongation Factor 1; D017346:Protein Serine-Threonine Kinases
keywords: Polyamine; Post-translation modification; Protein kinases; Signal transduction; Translation elongation factor 1A