title: Effect of acupuncture on clinical symptoms and laboratory indicators for chronic prostatitis/chronic pelvic pain syndrome: a systematic review and meta-analysis.
abstract: OBJECTIVE
  To systematically review the efficacy and safety of acupuncture for chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS).
  
  
  METHODS
  PubMed, Cochrane library Central, Web of Science, Wang-fang Database, and CNKI were searched from their inception to June 30, 2016. Data of acupuncture for CP/CPPS following randomized controlled trials (RCTs) was included. The data were analyzed using the Cochrane Collaboration Review Manager. The primary data were the National Institute of Health-Chronic Prostatitis Index (NIH-CPSI) score at the end of follow-up.
  
  
  RESULTS
  Ten RCTs were enrolled. Acupuncture was superior to the control in NIH-CPSI (MD -3.98, [95 % CI -5.78 to -2.19]; P < 0.0001) and response rate (RR 4.12, [95 % CI 1.67-10.18]; P = 0.002). Acupuncture was superior to sham acupuncture on NIH-CPSI, response rate, pain, urinary, and quality of life (QOL). Standard medication was inferior to acupuncture in terms of NIH-CPSI (MD -3.08, [95 % CI -5.57 to -0.60]; P = 0.02) and response rate (RR 2.03, [95 % CI 1.04-3.97]; P = 0.04), but standard medication was superior to acupuncture on improving urinary symptoms. There was no significant difference in the adverse events. Acupuncture/acupuncture plus standard medication significantly down-regulated IL-1β compared with standard medication in prostatic fluid.
  
  
  CONCLUSIONS
  Acupuncture treating CP/CPPS is effective and safe. The effects of acupuncture on NIH-CPSI, response rate, pain symptoms, and QOF were superior to the control, but standard medication significantly improved urinary symptoms compared with acupuncture. Acupuncture can decrease the IL-1β in prostatic fluid for CP/CPPS.
authors: Clinical Medical College of Acupuncture, Moxibustion and Rehabilitation, Guangzhou University of Chinese Medicine, No. 232, Waihuandong Road, Guangzhou University Town, Panyu District, Guangzhou, 510006, People's Republic of China. liubuping123@163.com.
authors: Bu-Ping
authors: http://orcid.org/0000-0002-1959-0632
authors: BP
authors: Liu
authors: Postgraduate Academy, Guangzhou University of Chinese Medicine, Guangzhou, People's Republic of China.
authors: Yun-Ting
authors: YT
authors: Wang
authors: The First Affiliated Hospital, Guangzhou University of Chinese Medicine, Guangzhou, People's Republic of China.
authors: Si-da
authors: SD
authors: Chen
mesh_terms: D015670:Acupuncture Therapy / Q000379:methods*; D002908:Chronic Disease; D006801:Humans; D008297:Male; D017699:Pelvic Pain / Q000209:etiology / Q000523:psychology / Q000628:therapy; D011472:Prostatitis / Q000150:complications / Q000175:diagnosis / Q000503:physiopathology / Q000628:therapy; D011788:Quality of Life; D016896:Treatment Outcome
keywords: Acupuncture; Chronic pelvic pain syndrome; Chronic prostatitis; Meta-analysis; Review