title: Viral Genome Sequencing Proves Nosocomial Transmission of Fatal Varicella.
abstract: We report the first use of whole viral genome sequencing to identify nosocomial transmission of varicella-zoster virus with fatal outcome. The index case patient, nursed in source isolation, developed disseminated zoster with rash present for 1 day before being transferred to the intensive care unit (ICU). Two patients who had received renal transplants while inpatients in an adjacent ward developed chickenpox and 1 died; neither patient had direct contact with the index patient.
authors: Division of Infection and Immunity, University College London.
authors: Daniel P
authors: DP
authors: Depledge
authors: Great Ormond Street Hospital VZV Reference Laboratory, Great Ormond Street Hospital, London.
authors: Julianne
authors: J
authors: Brown
authors: Wessex Renal and Transplant Services.
authors: Jasna
authors: J
authors: Macanovic
authors: Departments of Clinical Microbiology, Pathology Centre, Queen Alexandra Hospital, Cosham, Portsmouth, United Kingdom.
authors: Gill
authors: G
authors: Underhill
authors: Division of Infection and Immunity, University College London.
authors: Judith
authors: J
authors: Breuer
mesh_terms: D000368:Aged; D002644:Chickenpox / Q000635:transmission* / Q000821:virology*; D003428:Cross Infection / Q000635:transmission* / Q000821:virology*; D005260:Female; D016679:Genome, Viral / Q000235:genetics*; D006562:Herpes Zoster / Q000635:transmission / Q000821:virology; D014645:Herpesvirus 3, Human / Q000235:genetics*; D006801:Humans; D007362:Intensive Care Units; D016030:Kidney Transplantation / Q000009:adverse effects; D008297:Male; D008875:Middle Aged
keywords: fatal varicella; nosocomial transmission; whole genome sequencing