title: Effects of rhBNP after PCI on non-invasive hemodynamic in acute myocardial infarction patients with left heart failure.
abstract: OBJECTIVE
  To investigate the effects of exogenous recombinant human brain natriuretic peptide (rhBNP) after primary percutaneous coronary intervention (PCI) on non-invasive hemodynamic in acute myocardial infarction patients with left ventricular failure.
  
  
  METHODS
  A number of 96 acute myocardial infarction patients accompanied with heart failure after PCI hospitalized in the People's Hospital of Sanya during February 2012 to October 2015 were selected. They were randomly divided into the therapy group (n = 50) and control group (n = 46). On the basis of routine treatment, patients in the therapy group were treated with intravenous rhBNP (1.5 μg/kg was intravenous injection with uniform speed of 3 min, followed by continuous infusion 0.0075 μg/kg·min for 72 h), while the control group received conventional treatment. BioZ-2011 non-invasive hemodynamic real-time monitoring system was used to monitor the hemodynamic parameters changes and the leaves of plasma pro-BNP, serum creatinine, serum potassium, serum sodium and urine volume of each group before and after treating for 30 min, 1 h, 3 h, 6 h, 12 h, 24 h, 48 h, 72 h.
  
  
  RESULTS
  Patients in the therapy group showed no effect on heart rate, while after 30 min of intravenous injection of rhBNP, CO, CI, SV, and SI increased significantly and LVET and TFC reduced at the same time, which had certain effect on blood pressure (SBP/DBP). Compared with the control group, the therapy group showed a faster and more effective improvement on hemodynamics.
  
  
  CONCLUSIONS
  Acute myocardial infarction patients complicated with left heart failure after primary PCI can significantly improve hemodynamics by treating with rhBNP.
authors: Department of Cardiology, People's Hospital of Sanya, Sanya, Hainan Province, 572000, China.
authors: Xi-Min
authors: XM
authors: He
authors: Department of Cardiology, People's Hospital of Sanya, Sanya, Hainan Province, 572000, China.
authors: Lin
authors: L
authors: Chen
authors: Department of Cardiology, People's Hospital of Sanya, Sanya, Hainan Province, 572000, China.
authors: Jiang-Bin
authors: JB
authors: Luo
authors: Department of Cardiology, People's Hospital of Sanya, Sanya, Hainan Province, 572000, China.
authors: Xu-Xia
authors: XX
authors: Feng
authors: Department of Cardiology, People's Hospital of Sanya, Sanya, Hainan Province, 572000, China.
authors: Yun-Bo
authors: YB
authors: Zhang
authors: Department of Cardiology, People's Hospital of Sanya, Sanya, Hainan Province, 572000, China.
authors: Qi-Jing
authors: QJ
authors: Chen
authors: Department of Cardiology, People's Hospital of Sanya, Sanya, Hainan Province, 572000, China. Electronic address: 18689983939@163.com.
authors: Xiao-Li
authors: XL
authors: Ji
authors: Department of Cardiology, People's Hospital of Sanya, Sanya, Hainan Province, 572000, China.
authors: Tian-Song
authors: TS
authors: Wang
keywords: Acute myocardial infarction; Heart failure; Non-invasive hemodynamics; rhBNP