title: Cerebrospinal Fluid Alzheimer's Disease Biomarkers in Isolated Supratentorial Cortical Superficial Siderosis.
abstract: We evaluated cerebrospinal fluid amyloid-β 1-40 (Aβ40), amyloid-β 1-42 (Aβ42), total and phosphorylated-tau (t-tau and p-tau) in patients with symptomatic isolated cortical supratentorial superficial siderosis (SS), by prospectively recruiting ten patients with SS in the absence of pre-existing cognitive dysfunction, and comparing biomarkers with lobar hematoma cerebral amyloid angiopathy patients (LH-CAA, n = 13), Alzheimer's disease patients (AD, n = 42), and controls (n = 16). Compared to controls, SS patients showed statistically significant higher t-tau (p = 0.019) and lower Aβ42 (p = 0.0084). Compared to other groups, SS showed statistically significant lower t-tau, p-tau, and Aβ40 compared to AD (p = 0.0063, p = 0.0004, and p = 0022, respectively), and higher p-tau compared to LH-CAA (p = 0.012).
authors: Department of Neurology, CHU Nîmes, Hôpital Caremeau, Nîmes Cedex 4, France.
authors: Dimitri
authors: D
authors: Renard
authors: Laboratoire de Biochimie-Protéomique Clinique - IRMB - CCBHM - Inserm U11183, CHU Montpellier, Hôpital St-Eloi - Université Montpellier, Montpellier Cedex 5, France.|Centre Mémoire de Ressources et de Recherche Montpellier, Département de Neurologie, CHU Montpellier, Hôpital Gui de Chauliac - Université de Montpellier, Montpellier Cedex 5, France.
authors: Audrey
authors: A
authors: Gabelle
authors: Laboratoire de Biochimie-Protéomique Clinique - IRMB - CCBHM - Inserm U11183, CHU Montpellier, Hôpital St-Eloi - Université Montpellier, Montpellier Cedex 5, France.
authors: Christophe
authors: C
authors: Hirtz
authors: Department of biostatistics (BESPIM), Nîmes University Hospital, Nîmes cedex 9, France.
authors: Christophe
authors: C
authors: Demattei
authors: Department of Neurology, CHU Nîmes, Hôpital Caremeau, Nîmes Cedex 4, France.|Institut de Génomique Fonctionnelle, UMR5203, Université Montpellier, Montpellier Cedex 5, France.
authors: Eric
authors: E
authors: Thouvenot
authors: Laboratoire de Biochimie-Protéomique Clinique - IRMB - CCBHM - Inserm U11183, CHU Montpellier, Hôpital St-Eloi - Université Montpellier, Montpellier Cedex 5, France.
authors: Sylvain
authors: S
authors: Lehmann
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000134:cerebrospinal fluid* / Q000175:diagnosis; D016229:Amyloid beta-Peptides / Q000134:cerebrospinal fluid*; D015415:Biomarkers / Q000134:cerebrospinal fluid; D016657:Cerebral Amyloid Angiopathy / Q000134:cerebrospinal fluid* / Q000175:diagnosis; D015331:Cohort Studies; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D010446:Peptide Fragments / Q000134:cerebrospinal fluid*; D011446:Prospective Studies; D012806:Siderosis / Q000134:cerebrospinal fluid* / Q000175:diagnosis; D016875:tau Proteins / Q000134:cerebrospinal fluid*
chemical_list: D016229:Amyloid beta-Peptides; D015415:Biomarkers; C054369:MAPT protein, human; D010446:Peptide Fragments; C075222:amyloid beta-protein (1-42); D016875:tau Proteins
keywords: Amyloid-β; cerebral amyloid angiopathy; cerebrospinal fluid; superficial siderosis; tau