title: Clinical Significance of Component Allergens in Fagales Pollen-Sensitized Peanut Allergy in Korea.
abstract: OBJECTIVE
  Clinical features of peanut allergy can range from localized to systemic reactions. Because peanut and birch pollen have cross-reactivity, peanut can lead to localized allergic reaction in Fagales pollen-sensitized oral allergy syndrome (OAS) patients without peanut sensitization per se. The purpose of this study was to discriminate true peanut food allergy from cross-reactive hypersensitivity in birch-sensitized peanut allergy.
  
  
  METHODS
  Birch-sensitized (n=81) and peanut anaphylaxis patients (n=12) were enrolled. Peanut-related allergic reactions and sensitization profiles were examined. Specific IgE to Fagales tree pollens (birch, oak), peanut, and their component allergens (Bet v 1, Bet v 2, Ara h 1, Ara h 2, Ara h 3, Ara h 8, and Ara h 9) were evaluated. Based on these specific IgEs and clinical features, the patients were classified into 4 groups: group 1 (Fagales pollen allergy without OAS), group 2 (Fagales pollen allergy with OAS), group 3 (OAS with peanut anaphylaxis), and group 4 (peanut anaphylaxis).
  
  
  RESULTS
  After peanut consumption, one-third of OAS patients experienced oral symptoms not associated with peanut sensitization. Ara h 1 or Ara h 2 was positive in peanut anaphylaxis patients, whereas Ara h 8 was positive in OAS patients. There were 4 patients with both peanut anaphylaxis and OAS (group 3). Both Ara h 2 and Ara h 8 were positive in these patients. Foods associated with OAS in Korea showed unique patterns compared to Westernized countries.
  
  
  CONCLUSIONS
  Ara h 2 and Ara h 8 may be important component allergens for discriminating peanut allergy.
authors: Division of Allergy and Immunology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.|Institute of Allergy, Yonsei University College of Medicine, Seoul, Korea.
authors: Kyung Hee
authors: KH
authors: Park
authors: Division of Allergy and Immunology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.
authors: Young Woong
authors: YW
authors: Son
authors: Division of Allergy and Immunology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.
authors: Sang Chul
authors: SC
authors: Lee
authors: Department of Pediatrics, Ajou University School of Medicine, Suwon, Korea.
authors: Kyunguk
authors: K
authors: Jeong
authors: Division of Allergy and Immunology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.|Institute of Allergy, Yonsei University College of Medicine, Seoul, Korea.
authors: Da Woon
authors: da W
authors: Sim
authors: Division of Allergy and Immunology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.|Institute of Allergy, Yonsei University College of Medicine, Seoul, Korea.
authors: Hye Jung
authors: HJ
authors: Park
authors: Department of Pediatrics, Ajou University School of Medicine, Suwon, Korea.
authors: Sooyoung
authors: S
authors: Lee
authors: Division of Allergy and Immunology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.|Institute of Allergy, Yonsei University College of Medicine, Seoul, Korea.
authors: Jae Hyun
authors: JH
authors: Lee
authors: Division of Allergy and Immunology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.|Institute of Allergy, Yonsei University College of Medicine, Seoul, Korea. parkjw@yuhs.ac.
authors: Jung Won
authors: JW
authors: Park
keywords: Allergens; IgE; peanut hypersensitivity; pollen; trees