title: Bifunctional Luminomagnetic Rare-Earth Nanorods for High-Contrast Bioimaging Nanoprobes.
abstract: Nanoparticles exhibiting both magnetic and luminescent properties are need of the hour for many biological applications. A single compound exhibiting this combination of properties is uncommon. Herein, we report a strategy to synthesize a bifunctional luminomagnetic Gd2-xEuxO3 (x = 0.05 to 0.5) nanorod, with a diameter of ~20 nm and length in ~0.6 μm, using hydrothermal method. Gd2O3:Eu(3+) nanorods have been characterized by studying its structural, optical and magnetic properties. The advantage offered by photoluminescent imaging with Gd2O3:Eu(3+) nanorods is that this ultrafine nanorod material exhibits hypersensitive intense red emission (610 nm) with good brightness (quantum yield more than 90%), which is an essential parameter for high-contrast bioimaging, especially for overcoming auto fluorescent background. The utility of luminomagnetic nanorods for biological applications in high-contrast cell imaging capability and cell toxicity to image two human breast cancer cell lines T47D and MDA-MB-231 are also evaluated. Additionally, to understand the significance of shape of the nanostructure, the photoluminescence and paramagnetic characteristic of Gd2O3:Eu(3+) nanorods were compared with the spherical nanoparticles of Gd2O3:Eu(3+).
authors: Luminescent Materials and Devices Group, Materials Physics and Engineering Division, CSIR- National Physical Laboratory, Dr K S Krishnan Road, New Delhi, 110012, India.
authors: Bipin Kumar
authors: BK
authors: Gupta
authors: Luminescent Materials and Devices Group, Materials Physics and Engineering Division, CSIR- National Physical Laboratory, Dr K S Krishnan Road, New Delhi, 110012, India.|Academy of Scientific and Innovative Research (AcSIR), CSIR-National Physical Laboratory Campus, Dr K S Krishnan Road, New Delhi 110012, India.
authors: Satbir
authors: S
authors: Singh
authors: Luminescent Materials and Devices Group, Materials Physics and Engineering Division, CSIR- National Physical Laboratory, Dr K S Krishnan Road, New Delhi, 110012, India.|Academy of Scientific and Innovative Research (AcSIR), CSIR-National Physical Laboratory Campus, Dr K S Krishnan Road, New Delhi 110012, India.
authors: Pawan
authors: P
authors: Kumar
authors: Department of Material Science and Nano Engineering Rice University, Houston, TX 77005, USA.
authors: Yean
authors: Y
authors: Lee
authors: Department of Physics, Kalindi College, University of Delhi, New Delhi, 110008, India.
authors: Garima
authors: G
authors: Kedawat
authors: TIFR- Center for Interdisciplinary sciences, Tata Institute fundamental research, Hydrabad-500075, India.
authors: Tharangattu N
authors: TN
authors: Narayanan
authors: Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA.
authors: Sajna Antony
authors: SA
authors: Vithayathil
authors: Department of Material Science and Nano Engineering Rice University, Houston, TX 77005, USA.
authors: Liehui
authors: L
authors: Ge
authors: Department of Material Science and Nano Engineering Rice University, Houston, TX 77005, USA.
authors: Xiaobo
authors: X
authors: Zhan
authors: National Institute of Immunology, Aruna Aseaf Ali Marg, J. N. U. Complex, New Delhi-110067, India.
authors: Sarika
authors: S
authors: Gupta
authors: Department of Chemistry and Bioengineering, Rice University, Houston, Texas 77005, USA.
authors: Angel A
authors: AA
authors: Martí
authors: Department of Material Science and Nano Engineering Rice University, Houston, TX 77005, USA.
authors: Robert
authors: R
authors: Vajtai
authors: Department of Material Science and Nano Engineering Rice University, Houston, TX 77005, USA.
authors: Pulickel M
authors: PM
authors: Ajayan
authors: Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA.|Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA.
authors: Benny Abraham
authors: BA
authors: Kaipparettu
mesh_terms: D045744:Cell Line, Tumor; D004847:Epithelial Cells / Q000648:ultrastructure; D005063:Europium / Q000737:chemistry*; D005682:Gadolinium / Q000737:chemistry*; D006801:Humans; D049408:Luminescent Agents / Q000737:chemistry*; D008163:Luminescent Measurements; D059346:Magnets; D053758:Nanoparticles / Q000737:chemistry / Q000648:ultrastructure; D036103:Nanotechnology / Q000379:methods*; D043942:Nanotubes / Q000737:chemistry* / Q000648:ultrastructure; D061848:Optical Imaging / Q000379:methods*
chemical_list: D049408:Luminescent Agents; D005063:Europium; D005682:Gadolinium