title: β-Catenin-Independent Roles of Wnt/LRP6 Signaling.
abstract: Wnt/LRP6 signaling is best known for the β-catenin-dependent regulation of target genes. However, pathway branches have recently emerged, including Wnt/STOP signaling, which act independently of β-catenin and transcription. We review here the molecular mechanisms underlying β-catenin-independent Wnt/LRP6 signaling cascades and their implications for cell biology, development, and physiology.
authors: Division of Molecular Embryology, Deutsches Krebsforschungszentrum (DKFZ)-Zentrum für Molekulare Biologie der Universität Heidelberg (ZMBH) Alliance, 69120 Heidelberg, Germany. Electronic address: s.perezacebron@DKFZ-Heidelberg.de.
authors: Sergio P
authors: SP
authors: Acebron
authors: Division of Molecular Embryology, Deutsches Krebsforschungszentrum (DKFZ)-Zentrum für Molekulare Biologie der Universität Heidelberg (ZMBH) Alliance, 69120 Heidelberg, Germany; Institute of Molecular Biology, 55128 Mainz, Germany. Electronic address: Niehrs@DKFZ-Heidelberg.de.
authors: Christof
authors: C
authors: Niehrs
mesh_terms: D000818:Animals; D006801:Humans; D060488:Low Density Lipoprotein Receptor-Related Protein-6 / Q000378:metabolism*; D008954:Models, Biological; D055550:Protein Stability; D020239:Receptor Cross-Talk; D060449:Wnt Signaling Pathway; D051176:beta Catenin / Q000378:metabolism*
chemical_list: D060488:Low Density Lipoprotein Receptor-Related Protein-6; D051176:beta Catenin
keywords: GSK3; Wnt/STOP; mitosis; post-transcriptional Wnt signaling; proteolysis; β-catenin