title: Probiotics Lactobacillus plantarum and bifidobacterium B94: cognitive function in demyelinated model.
abstract: BACKGROUND
  Multiple Sclerosis (MS) is a disease of the immune system that creates damage of Learning and memory in that. Using probiotic supplements is recommended for preventing MS disease and improving memory. This study aimed to investigate the effect of Lactobacillus plantarum (LP) and bifidobacterium B94 (BB94), on acquisition phase of spatial memory in the local demyelination of rats` hippocampus.
  
  
  METHODS
  In this study, 32 male Wistar rats were divided into control, damage group and treatment groups. Treatment groups were including (LP) and (BB94). After the induction of demyelination by 3 μl of EB into the right dentate gyrus of the hippocampus in treatment groups, 1.5×10(8) probiotic bacteria were administered by gavage for 28 days. Data was analyzed using one-way ANOVA and Tukey post-hoc tests (p≤0.05).
  
  
  RESULTS
  Findings demonstrated that injection of EB caused a significant increase in traveled distance (p<0.01) and also escape latency (p<0.05) compared with control group. Also, effect administrations of (LP) and (BB94) on traveled distance and escape latency were reviewed, and it was determined that administration of them do not cause significant reduction in the traveled distance compared with the lesion group. Also mentioned probiotics has no significant effect on swimming speed compared with lesion and saline groups.
  
  
  CONCLUSIONS
  According to some studies, probiotics have a positive impact on improving the performance of spatial memory and learning, although the results of the current study could not indicate finality of this assumption. It seems that more researches is needed on this subject.
authors: PhD, Assistant Professor, Department of Pharmacology-Physiology, School of Medicine, Alborz University of Medical Sciences, Karaj, Iran. m118medical@yahoo.com.
authors: Mahdi
authors: M
authors: Goudarzvand
authors: MSc, Antimicrobial Resistance Research Centre, Rasoul-e-Akram Hospital, Iran University of Medical Sciences, Tehran, Iran. samirarasouli@yahoo.com.
authors: Samira
authors: S
authors: Rasouli Koohi
authors: PhD, Assistant Professor, Dietary Supplements and Probiotic Research Center, Alborz University of Medical Sciences, Karaj, Iran. zkhodaii@yahoo.com.
authors: Zohreh
authors: Z
authors: Khodaii
authors: MSc, Antimicrobial Resistance Research Centre, Rasoul-e-Akram Hospital, Iran University of Medical Sciences, Tehran, Iran. so.soleymanzadeh@yahoo.com.
authors: Somayeh
authors: S
authors: Soleymanzadeh Moghadam
keywords: demyelination; hippocampus; probiotic; spatial memory