title: Sleep Duration and Quality in Relation to Autonomic Nervous System Measures: The Multi-Ethnic Study of Atherosclerosis (MESA).
abstract: Short sleep duration and poor sleep quality are associated with adverse cardiovascular outcomes. Potential pathophysiological mechanisms include sleep-associated alterations in the autonomic nervous system. The objective of this study was to examine the associations of shorter sleep duration and poorer sleep quality with markers of autonomic tone: heart rate (HR), high-frequency HR variability (HF-HRV) and salivary amylase.
  
  
  
  Cross-sectional analysis of data from actigraphy-based measures of sleep duration and efficiency and responses to a challenge protocol obtained from 527 adult participants in the Multi-Ethnic Study of Atherosclerosis.
  
  
  
  Participants who slept fewer than 6 h per night (compared to those who slept 7 h or more per night) had higher baseline HR (fully adjusted model 0.05 log beats/min, 95% confidence interval [CI] 0.01, 0.09) and greater HR orthostatic reactivity (fully adjusted model 0.02 log beats/min, 95% CI 0.002, 0.023). Participants who slept 6 to less than 7 h/night (compared to those who slept 7 h or more per night) had lower baseline HF-HRV (fully adjusted model -0.31 log msec2, 95% CI -0.60, -0.14). Participants with low sleep efficiency had lower baseline HF-HRV than those with higher sleep efficiency (fully adjusted model -0.59 log msec2, 95% CI -1.03, -0.15). Participants with low sleep efficiency had higher baseline levels of amylase than those with higher sleep efficiency (fully adjusted model 0.45 log U/mL, 95% CI 0.04, 0.86).
  
  
  
  Short sleep duration, low sleep efficiency, and insomnia combined with short sleep duration were associated with markers of autonomic tone that indicate lower levels of cardiac parasympathetic (vagal) tone and/or higher levels of sympathetic tone.
authors: Department of Medicine, Columbia University College of Physicians & Surgeons, New York, NY.|Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY.
authors: Cecilia
authors: C
authors: Castro-Diehl
authors: Department of Epidemiology and Biostatistics, Drexel University School of Public Health, Philadelphia, PA.
authors: Ana V
authors: AV
authors: Diez Roux
authors: Departments of Medicine, Brigham and Women's Hospital and Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA.
authors: Susan
authors: S
authors: Redline
authors: Department of Medicine/Geriatrics, University of California, Los Angeles, CA.
authors: Teresa
authors: T
authors: Seeman
authors: Department of Medicine/Geriatrics, University of California, Los Angeles, CA.
authors: Paula
authors: P
authors: McKinley
authors: Division of Behavioral Medicine, Department of Psychiatry, Columbia University College of Physicians & Surgeons, New York, NY.
authors: Richard
authors: R
authors: Sloan
authors: Department of Medicine, Columbia University College of Physicians & Surgeons, New York, NY.|Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY.
authors: Steven
authors: S
authors: Shea
mesh_terms: D056044:Actigraphy; D000368:Aged; D000369:Aged, 80 and over; D000681:Amylases / Q000378:metabolism; D001341:Autonomic Nervous System / Q000502:physiology* / Q000503:physiopathology; D015415:Biomarkers / Q000378:metabolism; D003430:Cross-Sectional Studies; D005260:Female; D006339:Heart Rate / Q000502:physiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D012463:Saliva / Q000737:chemistry; D012890:Sleep / Q000502:physiology*; D012892:Sleep Deprivation / Q000503:physiopathology*; D007319:Sleep Initiation and Maintenance Disorders / Q000503:physiopathology*
chemical_list: D015415:Biomarkers; D000681:Amylases
keywords: HF-HRV and salivary amylase; insomnia; sleep duration; sleep efficiency