title: Regulation of Hematopoiesis and Osteogenesis by Blood Vessel-Derived Signals.
abstract: In addition to their conventional role as a versatile transport system, blood vessels provide signals controlling organ development, regeneration, and stem cell behavior. In the skeletal system, certain capillaries support perivascular osteoprogenitor cells and thereby control bone formation. Blood vessels are also a critical component of niche microenvironments for hematopoietic stem cells. Here we discuss key pathways and factors controlling endothelial cell behavior in bone, the role of vessels in osteogenesis, and the nature of vascular stem cell niches in bone marrow.
authors: Department of Tissue Morphogenesis, Max Planck Institute for Molecular Biomedicine, D-48169 Münster, Germany; email: ralf.adams@mpi-muenster.mpg.de.|Faculty of Medicine, University of Münster, D-48149 Münster, Germany.
authors: Saravana K
authors: SK
authors: Ramasamy
authors: Department of Tissue Morphogenesis, Max Planck Institute for Molecular Biomedicine, D-48169 Münster, Germany; email: ralf.adams@mpi-muenster.mpg.de.|Faculty of Medicine, University of Münster, D-48149 Münster, Germany.
authors: Anjali P
authors: AP
authors: Kusumbe
authors: Department of Immunology, The Weizmann Institute of Science, Rehovot, 76100, Israel; email: Tsvee.Lapidot@weizmann.ac.il.
authors: Tomer
authors: T
authors: Itkin
authors: Department of Immunology, The Weizmann Institute of Science, Rehovot, 76100, Israel; email: Tsvee.Lapidot@weizmann.ac.il.
authors: Shiri
authors: S
authors: Gur-Cohen
authors: Department of Immunology, The Weizmann Institute of Science, Rehovot, 76100, Israel; email: Tsvee.Lapidot@weizmann.ac.il.
authors: Tsvee
authors: T
authors: Lapidot
authors: Department of Tissue Morphogenesis, Max Planck Institute for Molecular Biomedicine, D-48169 Münster, Germany; email: ralf.adams@mpi-muenster.mpg.de.|Faculty of Medicine, University of Münster, D-48149 Münster, Germany.
authors: Ralf H
authors: RH
authors: Adams
mesh_terms: D000818:Animals; D001808:Blood Vessels / Q000378:metabolism*; D001853:Bone Marrow / Q000098:blood supply; D042783:Endothelial Cells / Q000378:metabolism; D006410:Hematopoiesis; D006801:Humans; D010012:Osteogenesis; D015398:Signal Transduction
keywords: angiocrine factors; bone angiogenesis; hematopoietic stem cells; vascular niche