title: A Simplified Geboes Score for Ulcerative Colitis.
abstract: OBJECTIVE
  The original Geboes Score [OGS] is the most commonly used histological score in ulcerative colitis [UC], but rather complicated to use in daily clinical practice. The aim of this study was to develop a Simplified Geboes Score [SGS] and to compare it with the OGS in patients newly diagnosed with UC.
  
  
  METHODS
  All patients diagnosed with UC at a tertiary referral centre between 2005 and 2010, who had serial colonoscopies with biopsies, were retrospectively included. The 5-year endoscopic/histological evolution after diagnosis was recorded. Histological activity was scored by an experienced inflammatory bowel disease pathologist and three trained readers using the OGS and also the new SGS that only includes variables linked to active inflammatory disease. The correlation between endoscopic and histological activity and the histological inter-observer agreement were measured.
  
  
  RESULTS
  A total of 528 slides from 339 colonoscopies of 103 UC patients were reviewed. Forty [12%] colonoscopies presented Mayo 0, 74 [22%] Mayo 1, 107 [31%] Mayo 2 and 118 [35%] Mayo 3. Active microscopic disease [≥ 3.1 in both scores] was described in 10/40 [25%] patients who were in complete endoscopic remission [Mayo 0], and 62/74 [84%] with mild endoscopic lesions [Mayo 1]. The correlation analysis between endoscopy and OGS/SGS did not show significant differences between the histological scores. The inter-observer agreement was moderate for all the grades of the SGS.
  
  
  CONCLUSIONS
  The assessments of histological activity based on the OGS and the SGS were comparable in newly diagnosed active UC patients. Further prospective validation should now be done to replace the OGS with the SGS.
authors: University Hospitals Leuven, Department of Gastroenterology, KU Leuven, Leuven, Belgium.|Translational Research Centre for Gastrointestinal Disorders [TARGID], Department of Clinical and Experimental Medicine, KU Leuven, Leuven, Belgium.
authors: Aranzazu
authors: A
authors: Jauregui-Amezaga
authors: University Hospitals Leuven, Department of Pathology, KU Leuven, Leuven, Belgium.
authors: Auke
authors: A
authors: Geerits
authors: University Hospitals Leuven, Department of Pathology, KU Leuven, Leuven, Belgium.
authors: Yannick
authors: Y
authors: Das
authors: University Hospitals Leuven, Department of Pathology, KU Leuven, Leuven, Belgium.
authors: Bart
authors: B
authors: Lemmens
authors: University Hospitals Leuven, Department of Pathology, KU Leuven, Leuven, Belgium.
authors: Xavier
authors: X
authors: Sagaert
authors: Mc Gill University Health Centre, Department of Gastroenterology, Montreal, Canada.
authors: Talat
authors: T
authors: Bessissow
authors: Hospital Universitari Germans Trias i Pujol, Department of Gastroenterology, Badalona, Spain.
authors: Triana
authors: T
authors: Lobatón
authors: University Hospitals Leuven, Department of Gastroenterology, KU Leuven, Leuven, Belgium.|Translational Research Centre for Gastrointestinal Disorders [TARGID], Department of Clinical and Experimental Medicine, KU Leuven, Leuven, Belgium.
authors: Marc
authors: M
authors: Ferrante
authors: University Hospitals Leuven, Department of Gastroenterology, KU Leuven, Leuven, Belgium.|Translational Research Centre for Gastrointestinal Disorders [TARGID], Department of Clinical and Experimental Medicine, KU Leuven, Leuven, Belgium.
authors: Gert
authors: G
authors: Van Assche
authors: University Hospitals Leuven, Department of Gastroenterology, KU Leuven, Leuven, Belgium.
authors: Raf
authors: R
authors: Bisschops
authors: University Hospitals Leuven, Department of Pathology, KU Leuven, Leuven, Belgium.
authors: Karel
authors: K
authors: Geboes
authors: University Hospitals Leuven, Department of Pathology, KU Leuven, Leuven, Belgium.
authors: Gert
authors: G
authors: De Hertogh
authors: University Hospitals Leuven, Department of Gastroenterology, KU Leuven, Leuven, Belgium.|Translational Research Centre for Gastrointestinal Disorders [TARGID], Department of Clinical and Experimental Medicine, KU Leuven, Leuven, Belgium.
authors: Séverine
authors: S
authors: Vermeire
mesh_terms: D000328:Adult; D001706:Biopsy; D003093:Colitis, Ulcerative / Q000000981:diagnostic imaging / Q000473:pathology*; D003106:Colon / Q000000981:diagnostic imaging / Q000473:pathology*; D003113:Colonoscopy; D005260:Female; D006801:Humans; D007413:Intestinal Mucosa / Q000000981:diagnostic imaging / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009504:Neutrophils; D015588:Observer Variation; D012189:Retrospective Studies; D012720:Severity of Illness Index; D055815:Young Adult
keywords: Histology; activity; ulcerative colitis