title: Traceless OH-Directed Wacker Oxidation-Elimination, an Alternative to Wittig Olefination/Aldol Condensation: One-Pot Synthesis of α,β-Unsaturated and Nonconjugated Ketones from Homoallyl Alcohols.
abstract: A new method for one-pot synthesis of β-substituted and β,β-disubstituted α,β-unsaturated methyl ketones from homoallyl alcohols by sequential PdCl2/CrO3-promoted Wacker process followed by an acid-mediated dehydration reaction has been developed. Remarkably, internal homoallyl alcohols delivered regioselectively nonconjugated unsaturated carbonyl compounds under the same protocol. A new starting material-based synthesis of α,β-unsaturated and nonconjugated methyl ketones is demonstrated.
authors: Department of Chemistry, Indian Institute of Technology Bombay , Powai, Mumbai, 400076 Maharashtra, India.
authors: Venkati
authors: V
authors: Bethi
authors: Department of Chemistry, Indian Institute of Technology Bombay , Powai, Mumbai, 400076 Maharashtra, India.
authors: Rodney A
authors: RA
authors: Fernandes