title: Impact of the PPAR gamma-2 gene polymorphisms on the metabolic state of postmenopausal women.
abstract: The relationship Pro12Ala (rs1801282) and C1431T (rs3856806) polymorphisms of PPAR gamma-2 with glucose and lipid metabolism is not clear after menopause. We investigated the impact of the Pro12Ala and C1431T silent substitution in the 6th exon in PPAR gamma-2 gene on nutritional and metabolic status in 271 postmenopausal women (122 lean and 149 obese). The general linear model (GLM) approach to the two-way analysis of variance (ANOVA) was used to infer the interactions between the analysed genotypes. The frequency of the Pro-T haplotype was higher in obese than in lean women (p less than 0.0349). In the analysed GLM models according to obesity status, the C1431C genotype was related to a lower glucose concentration (beta=-0.2103) in lean women, and to higher folliculotropic hormone FSH levels (beta=0.1985) and lower waist circumferences (beta=-0.1511) in obese women. The influence of C1431C was present regardless of the occurrence of the Pro12Ala polymorphism. The co-existence of the C1431C and Pro12Pro genotypes was related to lower values for triceps skinfold thickness compared those for the T1241/X and Ala12/X polymorphisms (beta=-0.1425). The presence of C1431C decreased the differences between triceps values that were determined by Pro or Ala allele. In conclusion, C1431T polymorphism seems to have a more essential influence on anthropometric and biochemical parameters than is the case with Pro12Ala polymorphism.
authors: Department of Bromatology and Human Nutrition, Poznan University of Medical Sciences, Poznan, Poland, bgrygiel@ump.edu.pl.
authors: Bogna
authors: B
authors: Grygiel-Gorniak
authors: Maria
authors: M
authors: Mosor
authors: Justyna
authors: J
authors: Marcinkowska
authors: Juliusz
authors: J
authors: Przyslawski
authors: Jerzy
authors: J
authors: Nowak
mesh_terms: D000368:Aged; D000886:Anthropometry; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006239:Haplotypes; D006801:Humans; D050356:Lipid Metabolism / Q000235:genetics; D008875:Middle Aged; D009765:Obesity / Q000235:genetics* / Q000473:pathology; D047495:PPAR gamma / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D017698:Postmenopause / Q000235:genetics*
chemical_list: D047495:PPAR gamma