title: Asymmetric Hydrogenation of Azaindoles: Chemo- and Enantioselective Reduction of Fused Aromatic Ring Systems Consisting of Two Heteroarenes.
abstract: High enantioselectivity was achieved for the hydrogenation of azaindoles by using the chiral catalyst, which was prepared from [Ru(η(3) -methallyl)2 (cod)] and a trans-chelating bis(phosphine) ligand (PhTRAP). The dearomative reaction exclusively occurred on the five-membered ring, thus giving the corresponding azaindolines with up to 97:3 enantiomer ratio.
authors: Department of Chemistry, Faculty of Science, and International Research Center for Molecular Systems (IRCMS), Kyushu University, 744 Motooka, Nishi-ku, Fukuoka, 819-0395, Japan.
authors: Yusuke
authors: 0000-0002-2999-4104
authors: Y
authors: Makida
authors: Department of Chemistry, Faculty of Science, and International Research Center for Molecular Systems (IRCMS), Kyushu University, 744 Motooka, Nishi-ku, Fukuoka, 819-0395, Japan.
authors: Masahiro
authors: M
authors: Saita
authors: Department of Chemistry, Faculty of Science, and International Research Center for Molecular Systems (IRCMS), Kyushu University, 744 Motooka, Nishi-ku, Fukuoka, 819-0395, Japan.
authors: Takahiro
authors: T
authors: Kuramoto
authors: Department of Chemistry, Faculty of Science, and International Research Center for Molecular Systems (IRCMS), Kyushu University, 744 Motooka, Nishi-ku, Fukuoka, 819-0395, Japan.
authors: Kentaro
authors: K
authors: Ishizuka
authors: Department of Chemistry, Faculty of Science, and International Research Center for Molecular Systems (IRCMS), Kyushu University, 744 Motooka, Nishi-ku, Fukuoka, 819-0395, Japan. rkuwano@chem.kyushu-univ.jp.
authors: Ryoichi
authors: 0000-0001-9994-6979
authors: R
authors: Kuwano
keywords: asymmetric catalysis; azaindoles; chemoselectivity; hydrogenation; ruthenium