title: Age at Onset of Alcohol Use and Alcohol Use Disorder: Time-trend Study in Patients Seeking De-addiction Services in Kerala.
abstract: BACKGROUND
  Declining age at onset of alcohol consumption over years has been one of the alarming findings in the epidemiology of alcoholism. The study was done to examine whether there was a decline in the age at onset of alcohol use and use disorder in subjects categorized as birth cohorts over the last 60 years seeking de-addiction services from a teaching hospital.
  
  
  METHODS
  A time-trend study, based on data collected from records, was done among 700 randomly selected subjects seeking de-addiction services. The study was done in a Government Medical College. Besides birth year, family history of alcohol use disorder and psychiatric comorbidity were the main independent variables studied. Trend was tested by linear regression.
  
  
  RESULTS
  There was a significant linear decline in the age at onset of alcohol use and use disorder. The mean age at onset of alcohol use and alcohol use disorder declined from 24 to 17 years and 46 to 21 years, respectively, from the pre-1950 birth cohort to the post-1985 birth cohort. Surprisingly, there was a plateau for mean age at onset of alcohol use during 1960s. The trend was significant even after adjusting for variables related to age at onset of alcohol consumption.
  
  
  CONCLUSIONS
  The trend of decreasing age at onset of alcohol use and alcohol use disorder over time has policy implications. Further studies are needed for exploring mediating or causal factors for the decline in the age at onset of alcohol use and use disorder.
authors: Department of Psychiatry, Government Medical College, Thiruvananthapuram, Kerala, India.
authors: Unnikrishnan Reghukumaran
authors: UR
authors: Nair
authors: Department of Psychiatry, Government Medical College, Thiruvananthapuram, Kerala, India.
authors: K
authors: K
authors: Vidhukumar
authors: Department of Psychiatry, Government Medical College, Thiruvananthapuram, Kerala, India.
authors: Anil
authors: A
authors: Prabhakaran
keywords: Age at onset; alcohol use; alcohol use disorder; time-trend