title: Aspirination of α-Aminoalcohol (Sarpogrelate M1).
abstract: Aspirination of α-aminoalcohol (sarpogrelate M1) has been performed under various general esterification conditions. In most cases, the desired aspirinate ester was obtained at a low yield with unexpected byproducts, the formation of which was mostly derived from the chemical properties of the tertiary α-amino group. After systematic analysis of those methods, the aspirinated sarpogrelate M1 was prepared using a two-step approach combining salicylate ester formation and acetylation.
authors: Integrated Research Institute of Pharmaceutical Sciences, College of Pharmacy, The Catholic University of Korea, Bucheon-si, Gyeonggi-do 420-743, Korea. sunalovegs@catholic.ac.kr.
authors: Sunhwa
authors: S
authors: Park
authors: Integrated Research Institute of Pharmaceutical Sciences, College of Pharmacy, The Catholic University of Korea, Bucheon-si, Gyeonggi-do 420-743, Korea. ljiy727@catholic.ac.kr.
authors: Jiyun
authors: J
authors: Lee
authors: Integrated Research Institute of Pharmaceutical Sciences, College of Pharmacy, The Catholic University of Korea, Bucheon-si, Gyeonggi-do 420-743, Korea. kyejung@catholic.ac.kr.
authors: Kye Jung
authors: KJ
authors: Shin
authors: Integrated Research Institute of Pharmaceutical Sciences, College of Pharmacy, The Catholic University of Korea, Bucheon-si, Gyeonggi-do 420-743, Korea. jaehongseo@catholic.ac.kr.
authors: Jae Hong
authors: JH
authors: Seo
mesh_terms: D000605:Amino Alcohols / Q000737:chemistry*; D001241:Aspirin / Q000737:chemistry*; D004951:Esterification; D013386:Succinates / Q000737:chemistry*
chemical_list: D000605:Amino Alcohols; D013386:Succinates; C064294:sarpogrelate; D001241:Aspirin
keywords: aspirin; esterification; sarpogrelate; α-aminoalcohol