title: Sleep disorders in Machado-Joseph disease.
abstract: This article provides a description on clinical features and pathophysiology of the main sleep disorders observed in Machado-Joseph disease (MJD).
  
  
  
  Pathological studies have clearly demonstrated that degenerative process in MJD is widespread in the nervous system, and not restricted to the cerebellum. Nonmotor manifestations are frequent and may include pain, cramps, dysautonomia, cognitive deficits, psychiatric manifestations, olfactory deficits, fatigue, nutritional issues, and sleep disorders.
  
  
  
  Sleep disorders are frequent in MJD, and include restless legs syndrome, rapid eye movement sleep behavior disorder, excessive daytime sleepiness, insomnia, sleep apnea, periodic limb movements during sleep, parasomnia, and others. Pathophysiological mechanisms related to sleep disorders in Machado-Joseph are complex and poorly understood. Considering that sleep complaints are a treatable condition, recognizing sleep disorders in MJD is relevant.
authors: aDivision of General Neurology and Ataxia Unit, Department of Neurology, Universidade Federal de São Paulo, São Paulo, São Paulo bDivision of Neurology, Department of Clinical Medicine, Universidade Federal do Ceará cCenter of Health Sciences, Universidade Estadual do Ceará, Ceará, Fortaleza dDepartment of Neurology, Universidade Estadual de Campinas, São Paulo, Campinas eUniversity of Fortaleza, Ceará, Fortaleza fNeuro-Sono Sleep Center, Department of Neurology, Universidade Federal de São Paulo, São Paulo, São Paulo, Brazil.
authors: José Luiz
authors: JL
authors: Pedroso
authors: Pedro
authors: P
authors: Braga-Neto
authors: Alberto R M
authors: AR
authors: Martinez
authors: Carlos R
authors: CR
authors: Martins
authors: Flávio M
authors: FM
authors: Rezende Filho
authors: Manoel A
authors: MA
authors: Sobreira-Neto
authors: Lucila B F
authors: LB
authors: Prado
authors: Gilmar F
authors: GF
authors: do Prado
authors: Marcondes C
authors: MC
authors: França
authors: Orlando G P
authors: OG
authors: Barsottini
mesh_terms: D006801:Humans; D017827:Machado-Joseph Disease / Q000150:complications*; D012893:Sleep Wake Disorders / Q000209:etiology*