title: GLP-1 and GLP-2 Levels are Correlated with Satiety Regulation After Roux-en-Y Gastric Bypass: Results of an Exploratory Prospective Study.
abstract: Changes in satiety regulation are known to play a pivotal role in the weight loss effects of Roux-en-Y gastric bypass (RYGB) and the mechanisms by which these changes occur are not entirely known. There are previous reports of the influence of GLP-1 to cause enhancement of satiation, but in regard to GLP-2, it remains unclear. This study aimed to determine whether there is a correlation between the levels of GLP-1 and GLP-2 and satiety regulation following RYGB.
  
  
  
  An exploratory prospective cohort study was made which enrolled 11 individuals who underwent RYGB and were followed-up for 12 months. GLP-1 and GLP-2 levels were determined before and after surgery and correlated with visual analogue scale scores for satiety.
  
  
  
  GLP-2 AUC after standard meal tolerance test (MTT) was significantly higher following surgery (945.3 ± 449.1 versus 1787.9 ± 602.7; p = 0.0037). Postoperatively, GLP-1 AUC presented a significant negative correlation with the mean score obtained in the first question of the visual analogue scale ("how hungry do you feel?") (p = 0.008); GLP-2 AUC presented a significant positive correlation with the mean score of the third ("how full do you feel?") question, and a significant positive correlation with the mean score achieved in the fourth question ("how much do you think you can eat?"), (p = 0.005 and p = 0.042, respectively).
  
  
  
  GLP-1 and GLP-2 were significantly correlated with satiety assessment within this sample. Further research is necessary to confirm these findings.
authors: State University of Campinas (UNICAMP), Campinas, SP, Brazil. notrevezzo@yahoo.com.br.
authors: Everton
authors: 0000-0002-5804-1580
authors: E
authors: Cazzo
authors: State University of Campinas (UNICAMP), Campinas, SP, Brazil.
authors: José Carlos
authors: JC
authors: Pareja
authors: State University of Campinas (UNICAMP), Campinas, SP, Brazil.
authors: Elinton Adami
authors: EA
authors: Chaim
authors: State University of Campinas (UNICAMP), Campinas, SP, Brazil.
authors: Bruno
authors: B
authors: Geloneze
authors: State University of Campinas (UNICAMP), Campinas, SP, Brazil.
authors: Maria Rita Lazzarini
authors: MR
authors: Barreto
authors: State University of Campinas (UNICAMP), Campinas, SP, Brazil.
authors: Daniéla Oliveira
authors: DO
authors: Magro
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001069:Appetite Regulation; D005260:Female; D015390:Gastric Bypass / Q000379:methods*; D052216:Glucagon-Like Peptide 1 / Q000097:blood*; D053767:Glucagon-Like Peptide 2 / Q000097:blood*; D006801:Humans; D006815:Hunger / Q000502:physiology; D008297:Male; D008875:Middle Aged; D009767:Obesity, Morbid / Q000097:blood / Q000378:metabolism / Q000601:surgery*; D011184:Postoperative Period; D011446:Prospective Studies; D012527:Satiation / Q000502:physiology*; D015431:Weight Loss / Q000502:physiology; D055815:Young Adult
chemical_list: D053767:Glucagon-Like Peptide 2; D052216:Glucagon-Like Peptide 1
keywords: Bariatric surgery; Gastric bypass; Glucagon-like peptides; Obesity; Satiety response