title: Laser therapy for the treatment of pearly penile papules.
abstract: Pearly penile papules (PPP) present as dome-shaped papules of no more than 3 mm in diameter that line the base of the glans of the penis. These benign lesions affect between 14.3 and 48 % of men. While often asymptomatic, PPP can cause a great deal of psychological distress that may warrant treatment. Current treatment options include cryotherapy, electrodessication, and curettage (ED&C). However, these modalities may have considerable adverse cosmetic effects, including scarring, pain, and pigmentary changes. Laser modalities offer clear potential for improved cosmetic outcome in PPP treatment, but is not routinely used. Thus, a systematic review of available literature using the National Library of Medicine database PubMed was completed to find articles relevant to the treatment of PPP with laser and light therapy. The systematic search and screening of articles resulted in inclusion of eight articles discussing a total of 55 patients with PPP treated by laser therapy. The present systematic review found that erbium:yttrium-aluminum-garnet (Er:YAG) and CO2laser were the most commonly reported (n = 45 and 7, respectively). Furthermore, the use of CO2, Er:YAG, pulsed dye laser, and fractional photothermolysis therapies demonstrated complete clearance of PPP in all cases with minimal complications and discomfort. Thus, based on the currently available evidence, laser therapy is a well-tolerated and efficacious method for treating PPP with minimal long-term adverse effects and a cosmetically desirable outcome. Although the included studies are limited in power, this systematic review offers clinically relevant insight into the potential for laser therapy.
authors: Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, 1475 NW 12th Ave., Miami, FL, 33136, USA. emaranda@med.miami.edu.
authors: Eric L
authors: EL
authors: Maranda
authors: Feinberg School of Medicine at Northwestern University, Chicago, IL, USA.
authors: Lisa
authors: L
authors: Akintilo
authors: University of South Florida Morsani College of Medicine, Tampa, FL, USA.
authors: Kelsey
authors: K
authors: Hundley
authors: Creighton University School of Medicine, Omaha, NE, USA.
authors: Austin H
authors: AH
authors: Nguyen
authors: Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, 1475 NW 12th Ave., Miami, FL, 33136, USA.
authors: Kevin J
authors: KJ
authors: Moore
authors: New York Medical College, Valhalla, NY, USA.
authors: Joseph
authors: J
authors: Zullo
authors: Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, 1475 NW 12th Ave., Miami, FL, 33136, USA.
authors: Joaquin J
authors: JJ
authors: Jimenez
mesh_terms: D006801:Humans; D053685:Laser Therapy / Q000379:methods*; D008297:Male; D010412:Penile Neoplasms / Q000601:surgery*
keywords: Hirsutoid papillomas; Laser therapy; Pearly penile papules; Systematic review; Treatment