title: Cytotoxic Meroterpenoids with Rare Skeletons from Psidium guajava Cultivated in Temperate Zone.
abstract: Three new meroterpenoids, guajavadials A-C (1-3), were isolated from Psidium guajava cultivated in temperate zone. Their structures were established by extensive spectroscopic evidence and electronic circular dichroism (ECD) calculations. Guajavadial A (1) represents a novel skeleton of the 3,5-diformylbenzyl phloroglucinol-coupled monoterpenoid, while guajavadials B (2) and C (3) are new adducts of the 3,5-diformylbenzyl phloroglucinol and a sesquiterpene with different coupling models. The plausible biosynthetic pathways as well as antimicrobial and cytotoxic activities of these meroterpenoids are also discussed. All these isolates exhibited moderate cytotoxicities against five human cancer cell lines, with 3 being most effective with an IC50 value of 3.54 μM toward SMMC-7721 cell lines.
authors: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, P. R. China.
authors: Xu-Jie
authors: XJ
authors: Qin
authors: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, P. R. China.
authors: Huan
authors: H
authors: Yan
authors: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, P. R. China.
authors: Wei
authors: W
authors: Ni
authors: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, P. R. China.|University of Chinese Academy of Sciences, Beijing 100049, P. R. China.
authors: Mu-Yuan
authors: MY
authors: Yu
authors: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, P. R. China.|Department of Chemistry, COMSATS Institute of Information Technology, Abbottabad-22060, Pakistan.
authors: Afsar
authors: A
authors: Khan
authors: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, P. R. China.|University of Chinese Academy of Sciences, Beijing 100049, P. R. China.
authors: Hui
authors: H
authors: Liu
authors: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, P. R. China.
authors: Hong-Xia
authors: HX
authors: Zhang
authors: Department of Dermatology, The First Affiliated Hospital of Kunming Medical University, Kunming 650032, P. R. China.
authors: Li
authors: L
authors: He
authors: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, P. R. China.
authors: Xiao-Jiang
authors: XJ
authors: Hao
authors: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, P. R. China.
authors: Ying-Tong
authors: YT
authors: Di
authors: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, P. R. China.
authors: Hai-Yang
authors: HY
authors: Liu
mesh_terms: D000890:Anti-Infective Agents / Q000737:chemistry / Q000302:isolation & purification; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000302:isolation & purification*; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D002942:Circular Dichroism; D006801:Humans; D020128:Inhibitory Concentration 50; D064209:Phytochemicals / Q000737:chemistry* / Q000302:isolation & purification*; D031647:Psidium / Q000737:chemistry*; D013057:Spectrum Analysis; D013729:Terpenes / Q000737:chemistry* / Q000302:isolation & purification*
chemical_list: D000890:Anti-Infective Agents; D000970:Antineoplastic Agents; D064209:Phytochemicals; D013729:Terpenes