title: How γ-secretase hits a moving target.
abstract: An improved understanding of the ways that amyloid-beta peptides are formed could help efforts to find a treatment for Alzheimer's disease.
authors: Department of Biochemistry, Vanderbilt Univeristy, Nashville, United States.
authors: Charles R
authors: 0000-0003-2046-2862
authors: CR
authors: Sanders
mesh_terms: D000544:Alzheimer Disease; D053829:Amyloid Precursor Protein Secretases; D016229:Amyloid beta-Peptides; D016564:Amyloid beta-Protein Precursor; D010450:Endopeptidases; D006801:Humans
chemical_list: D016229:Amyloid beta-Peptides; D016564:Amyloid beta-Protein Precursor; D053829:Amyloid Precursor Protein Secretases; D010450:Endopeptidases
keywords: Alzheimer's disease; C99; amyloid-beta peptides; biochemistry; cell biology; gamma-secretase; intramembrane protease; presenilin; processive