title: Finding DNA Ends within a Haystack of Chromatin.
abstract: Identifying DNA fragile sites is crucial to reveal hotspots of genomic rearrangements, yet their precise mapping has been a challenge. A new study in this issue of Molecular Cell (Canela et al., 2016) introduces a highly sensitive and accurate method to detect DNA breaks in vivo that can be adapted to various experimental and clinical settings.
authors: Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), 67404 Illkirch, France; Institut National de la Santé et de la Recherche Médicale (INSERM), U964, 67404 Illkirch, France; Centre National de Recherche Scientifique (CNRS), UMR7104, 67404 Illkirch, France; Université de Strasbourg, 67081 Strasbourg, France.
authors: Ujjwal
authors: U
authors: Banerjee
authors: Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), 67404 Illkirch, France; Institut National de la Santé et de la Recherche Médicale (INSERM), U964, 67404 Illkirch, France; Centre National de Recherche Scientifique (CNRS), UMR7104, 67404 Illkirch, France; Université de Strasbourg, 67081 Strasbourg, France. Electronic address: evisou@igbmc.fr.
authors: Evi
authors: E
authors: Soutoglou
mesh_terms: D002843:Chromatin; D043283:Chromosome Fragile Sites; D004247:DNA; D016678:Genome; D023281:Genomics; D006801:Humans
chemical_list: D002843:Chromatin; D004247:DNA