title: Overexpression of TAZ promotes cell proliferation, migration and epithelial-mesenchymal transition in ovarian cancer.
abstract: The Hippo pathway is dysregulated in multiple types of human cancer, including ovarian cancer. Nuclear expression of yes-associated protein 1 (YAP1), a downstream transcription coactivator of the Hippo pathway, has been demonstrated to promote tumorigenesis in ovarian cancer and may serve as a poor prognostic indicator. However, transcriptional coactivator with PDZ binding motif (TAZ), a downstream target of the Hippo pathway and paralog of YAP in mammalian cells, has not been fully investigated in ovarian cancer. The present study aimed to investigate the dysregulation and biological function of TAZ in ovarian cancer. Reverse transcription-quantitative polymerase chain reaction and western blotting revealed that TAZ mRNA and protein levels, respectively, were upregulated in ovarian cancer, and a meta-analysis of ovarian cancer microarray datasets identified that increased expression of TAZ mRNA is correlated with poor prognosis in patients with ovarian cancer. In addition, TAZ-knockdown in ovarian cancer cells demonstrated that TAZ regulates the migration, proliferation and epithelial-mesenchymal transition of ovarian cancer cells. Furthermore, pharmacological disruption of the YAP/TAZ/TEA domain protein complex resulted in a decrease in ovarian cancer cell migration, proliferation and vimentin expression. The results of the present study indicate that the overexpression of TAZ is important in the development and progression of ovarian cancer, and may function as a potential drug target for treatment of this disease entity.
authors: Department of Gynecology, Songgang People's Hospital, Shenzhen, Guangdong 518105, P.R. China.
authors: Guangyuan
authors: G
authors: Chen
authors: Department of Gynecology, Songgang People's Hospital, Shenzhen, Guangdong 518105, P.R. China.
authors: Jiabin
authors: J
authors: Xie
authors: Department of Gynecology, Songgang People's Hospital, Shenzhen, Guangdong 518105, P.R. China.
authors: Ping
authors: P
authors: Huang
authors: Department of Gynecology, Songgang People's Hospital, Shenzhen, Guangdong 518105, P.R. China.
authors: Zhihong
authors: Z
authors: Yang
keywords: Hippo pathway; ovarian cancer; transcriptional coactivator with PDZ binding motif; verteporfin