title: Catalytic Asymmetric Decarboxylative Mannich Reaction of Malonic Acid Half Esters with Cyclic Aldimines: Access to Chiral β-Amino Esters and Chroman-4-amines.
abstract: An enantioselective decarboxylative Mannich reaction of malonic acid half esters (MAHEs) with cyclic aldimines has been accomplished by employing the copper(I)/(R,R)-Ph-Box complex as chiral catalyst. The desired β-amino esters were obtained in good to high yields with excellent enantioselectivities. Furthermore, one of the corresponding Mannich products could be readily transformed into chiral chroman-4-amines without loss of enantioselectivity, which is a key intermediate of the human Bradykinin B1 receptor antagonist.
authors: Department of Chemistry, Tianjin Key Laboratory of Molecular Optoelectronic Sciences, Tianjin University, and Collaborative Innovation Center of Chemical Science and Engineering , Tianjin 300072, P. R. of China.
authors: Chun-Man
authors: CM
authors: Jia
authors: Department of Chemistry, Tianjin Key Laboratory of Molecular Optoelectronic Sciences, Tianjin University, and Collaborative Innovation Center of Chemical Science and Engineering , Tianjin 300072, P. R. of China.
authors: Heng-Xia
authors: HX
authors: Zhang
authors: Department of Chemistry, Tianjin Key Laboratory of Molecular Optoelectronic Sciences, Tianjin University, and Collaborative Innovation Center of Chemical Science and Engineering , Tianjin 300072, P. R. of China.
authors: Jing
authors: J
authors: Nie
authors: Department of Chemistry, Tianjin Key Laboratory of Molecular Optoelectronic Sciences, Tianjin University, and Collaborative Innovation Center of Chemical Science and Engineering , Tianjin 300072, P. R. of China.
authors: Jun-An
authors: JA
authors: Ma