title: Amine Activation: Synthesis of N-(Hetero)arylamides from Isothioureas and Carboxylic Acids.
abstract: A novel method for N-(hetero)arylamide synthesis based on rarely explored amine activation, rather than classical acid activation, is reported. The activated amines are easily prepared using a three-component reaction with commercial reagents. The new method shows a broad scope including challenging amides not (efficiently) accessible via classical protocols.
authors: Organic Synthesis, Department of Chemistry, University of Antwerp , Groenenborgerlaan 171, 2020 Antwerp, Belgium.
authors: Yan-Ping
authors: YP
authors: Zhu
authors: Organic Synthesis, Department of Chemistry, University of Antwerp , Groenenborgerlaan 171, 2020 Antwerp, Belgium.
authors: Sergey
authors: S
authors: Sergeyev
authors: Organic Synthesis, Department of Chemistry, University of Antwerp , Groenenborgerlaan 171, 2020 Antwerp, Belgium.
authors: Philippe
authors: P
authors: Franck
authors: Department of Chemistry and Pharmaceutical Sciences and Amsterdam Institute for Molecules, Medicines and Systems (AIMMS), VU University Amsterdam , De Boelelaan 1083, 1081 HV Amsterdam, The Netherlands.
authors: Romano V A
authors: RV
authors: Orru
authors: Organic Synthesis, Department of Chemistry, University of Antwerp , Groenenborgerlaan 171, 2020 Antwerp, Belgium.
authors: Bert U W
authors: BU
authors: Maes