title: Studies on the mechanism of bacterial flagellar rotation and the flagellar number regulation.
abstract: Many motile bacteria have the motility organ, the flagellum. It rotates by the rotary motor driven by the ion-motive force and is embedded in the cell surface at the base of each flagellar filament. Many researchers have been studying its rotary mechanism for years, but most of the energy conversion processes have been remained in mystery. We focused on the flagellar stator, which works at the core process of energy conversion, and found that the periplasmic region of the stator changes its conformation to be activated only when the stator units are incorporated into the motor and anchored at the cell wall. Meanwhile, the physiologically important supramolecular complex is localized in the cell at the right place and the right time with a proper amount. How the cell achieves such a proper localization is the fundamental question for life science, and we undertake this problem by analyzing the mechanism for biogenesis of a single polar flagellum of Vibrio alginolyticus. Here I describe the molecular mechanism of how the flagellum is generated at the specific place with a proper number, and also how the flagellar stator is incorporated into the motor to complete the functional motor assembly, based on our studies.
authors: Division of Biological Science, Graduate School of Science, Nagoya University.
authors: Seiji
authors: S
authors: Kojima
mesh_terms: D004734:Energy Metabolism / Q000502:physiology; D005407:Flagella / Q000235:genetics* / Q000502:physiology* / Q000648:ultrastructure; D008854:Microscopy, Electron; D020409:Molecular Motor Proteins / Q000235:genetics* / Q000502:physiology*; D012399:Rotation; D019779:Salmonella enterica / Q000166:cytology / Q000502:physiology; D044149:Vibrio alginolyticus / Q000166:cytology* / Q000502:physiology*
chemical_list: D020409:Molecular Motor Proteins