title: Autoreactive IgE in Chronic Spontaneous/Idiopathic Urticaria and Basophil/Mastocyte Priming Phenomenon, as a Feature of Autoimmune Nature of the Syndrome.
abstract: Recent years of research have shed a new light on the role of IgE in immune reactions. It seems to be more than just a contribution to immediate type of allergic response. It appears that monomeric IgE may enhance mast cell activity without cross-linking of FcεRI by IgE specific allergen or autoreactive IgG anti-IgE antibodies. Monomeric IgE molecules are heterogeneous concerning their ability to induce survival and activation of mast cells only by binding the IgE to FcεRI, but not affecting degranulation of cells. It also turned out that IgE may react to autoantigens occurring in the blood not only in chronic spontaneous urticaria (CSU) but also in other autoimmune diseases. The aforementioned phenomena may promote the activity of mast cells/basophils in CSU that easily degranulate when influenced by various inner (autoreactive IgG against IgE and FcεRI, autoreactive IgE for self-antigens) and outer factors (cold, heat, pressure) or allergens. These findings forced the new approach to the role of autoimmunity, self-antigens and IgE autoantibodies in the pathology of CSU. CSU put in the scheme of autoreactive IgG and autoreactive IgE seems to be either a kind of an autoimmune disease or a clinical manifestation of some other defined autoimmune diseases or both.
authors: Department of Internal Medicine and Allergy, Wroclaw Medical University, Curie-Skłodowskiej 66, 50-367, Wrocław, Poland. bernard.panaszek@umed.wroc.pl.
authors: Bernard
authors: B
authors: Panaszek
authors: Department of Internal Medicine and Allergy, Wroclaw Medical University, Curie-Skłodowskiej 66, 50-367, Wrocław, Poland.
authors: Robert
authors: R
authors: Pawłowicz
authors: Department of Histology and Embryology, Wroclaw Medical University, Wrocław, Poland.
authors: Jędrzej
authors: J
authors: Grzegrzółka
authors: Department of Internal Medicine and Allergy, Wroclaw Medical University, Curie-Skłodowskiej 66, 50-367, Wrocław, Poland.
authors: Andrzej
authors: A
authors: Obojski
mesh_terms: D000485:Allergens / Q000276:immunology; D000888:Antibodies, Anti-Idiotypic / Q000276:immunology*; D001323:Autoantibodies / Q000097:blood; D001324:Autoantigens / Q000276:immunology; D015551:Autoimmunity; D001491:Basophils / Q000166:cytology*; D002908:Chronic Disease; D006801:Humans; D007074:Immunoglobulin G / Q000276:immunology; D007453:Iodide Peroxidase / Q000276:immunology; D008407:Mast Cells / Q000276:immunology; D017455:Receptors, IgE / Q000276:immunology; D014581:Urticaria / Q000097:blood / Q000276:immunology* / Q000628:therapy
chemical_list: D000485:Allergens; D000888:Antibodies, Anti-Idiotypic; D001323:Autoantibodies; D001324:Autoantigens; D007074:Immunoglobulin G; D017455:Receptors, IgE; C026408:anti-IgE antibodies; D007453:Iodide Peroxidase
keywords: Autoimmune reactivity; Autoreactive IgE; Chronic urticaria; Mastocyte priming; Self-antigens