title: Influence of Experimental Conditions on Electronic Tongue Results-Case of Valsartan Minitablets Dissolution.
abstract: A potentiometric electronic tongue was applied to study the release of valsartan from pharmaceutical formulations, i.e., minitablets uncoated and coated with Eudragit E. Special attention was paid to evaluate the influence of medium temperature and composition, as well as to compare the performances of the sensor arrays working in various hydrodynamic conditions. The drug dissolution profiles registered with the ion-sensitive electrodes were compared with standard dissolution tests performed with USP Apparatus 2 (paddle). Moreover, the signal changes of all sensors were processed by principal component analysis to visualize the release modifications, related to the presence of the coating agent. Finally, the importance and influence of the experimental conditions on the results obtained using potentiometric sensor arrays were discussed.
authors: Department of Microbioanalytics, Warsaw University of Technology, Noakowskiego 3, Warsaw 00-664, Poland. mwesoly@ch.pw.edu.pl.
authors: Małgorzata
authors: M
authors: Wesoły
authors: Department of Applied Pharmacy, Gdańsk Medical University, Al. Gen. J. Hallera 107, Gdansk 80-416, Poland. ankl@gumed.edu.pl.
authors: Anna
authors: A
authors: Kluk
authors: Department of Applied Pharmacy, Gdańsk Medical University, Al. Gen. J. Hallera 107, Gdansk 80-416, Poland. msznito@gumed.edu.pl.
authors: Małgorzata
authors: M
authors: Sznitowska
authors: Department of Microbioanalytics, Warsaw University of Technology, Noakowskiego 3, Warsaw 00-664, Poland. pciosek@ch.pw.edu.pl.
authors: Patrycja
authors: P
authors: Ciosek
authors: Department of Microbioanalytics, Warsaw University of Technology, Noakowskiego 3, Warsaw 00-664, Poland. wuwu@ch.pw.edu.pl.
authors: Wojciech
authors: W
authors: Wróblewski
mesh_terms: D004563:Electrochemistry; D004566:Electrodes; D062609:Electronic Nose; D011109:Polymethacrylic Acids / Q000737:chemistry; D025341:Principal Component Analysis; D012815:Signal Processing, Computer-Assisted; D012995:Solubility; D013607:Tablets; D000068756:Valsartan / Q000032:analysis*
chemical_list: D011109:Polymethacrylic Acids; D013607:Tablets; C038300:methylmethacrylate-methacrylic acid copolymer; D000068756:Valsartan
keywords: dissolution test; drug release; electronic tongue; minitablets; potentiometric sensors; taste-masking; valsartan