title: Possible Mechanisms Involved in Attenuation of Lipopolysaccharide-Induced Memory Deficits by Methyl Jasmonate in Mice.
abstract: This present study was carried out to investigate the likely mechanisms by which methyl jasmonate (MJ), 'an agent widely used in aromatherapy for neurological disorders, attenuates lipopolysaccharide (LPS)-induced memory deficits in mice. Mice were given intraperitoneal administration of LPS (250 µg/kg) alone or in combination with MJ (10-40 mg/kg), donepezil, DP (1 mg/kg), or vehicle for 7 successive days. Thereafter, memory was assessed using object recognition test (ORT). Acetylcholinesterase and myeloperoxidase activities were estimated in brain tissue homogenates. Brain levels of nitric oxide and markers of oxidative stress as well as histopathologic changes of the prefrontal cortex and cornu ammonis 1 (CA1) of the hippocampal region were also assessed. MJ (10-40 mg/kg) attenuated LPS-induced memory impairment in ORT. Moreover, the increased brain activities of acetylcholinesterase and myeloperoxidase enzymes were suppressed by MJ when compared with control (p < 0.05). Increased brain oxidative stress and nitric oxide levels in LPS-treated mice were significantly decreased by MJ. It offers protection against LPS-induced neuronal degeneration of the prefrontal cortex and CA1 of the hippocampus, suggesting neuroprotective effect. Taken together, these findings showed that MJ offers protection against LPS-induced memory deficits via mechanisms related to inhibition of acetylcholinesterase, myeloperoxidase, oxidative stress and neuronal degeneration.
authors: Neuropharmacology unit, Department of Pharmacology and Therapeutics, College of Medicine, University of Ibadan, Ibadan, Nigeria.|Department of Pharmacology and Therapeutics, College of Medicine and Health Sciences, Afe Babalola University, Ado-Ekiti, Nigeria.
authors: Anthony Taghogho
authors: AT
authors: Eduviere
authors: Neuropharmacology unit, Department of Pharmacology and Therapeutics, College of Medicine, University of Ibadan, Ibadan, Nigeria. umusolo@yahoo.com.
authors: Solomon
authors: S
authors: Umukoro
authors: Department of Pharmacology and Therapeutics, College of Medicine and Health Sciences, Afe Babalola University, Ado-Ekiti, Nigeria.
authors: Olusegun A
authors: OA
authors: Adeoluwa
authors: Department of Pharmacology and Therapeutics, College of Health Sciences, Delta State University, Abraka, Nigeria.
authors: Itivere Adrian
authors: IA
authors: Omogbiya
authors: Department of Pharmacology and Therapeutics, College of Health Sciences, Bowen University, Iwo, Osun State, Nigeria.
authors: Oritoke Modupe
authors: OM
authors: Aluko
mesh_terms: D000085:Acetates / Q000494:pharmacology* / Q000627:therapeutic use; D000110:Acetylcholinesterase / Q000378:metabolism; D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D003517:Cyclopentanes / Q000494:pharmacology* / Q000627:therapeutic use; D008070:Lipopolysaccharides / Q000494:pharmacology*; D008569:Memory Disorders / Q000139:chemically induced / Q000188:drug therapy* / Q000378:metabolism / Q000523:psychology; D051379:Mice; D018696:Neuroprotective Agents / Q000494:pharmacology* / Q000627:therapeutic use; D009573:Nitrites / Q000378:metabolism; D018384:Oxidative Stress / Q000187:drug effects; D054883:Oxylipins / Q000494:pharmacology* / Q000627:therapeutic use; D021641:Recognition, Psychology / Q000187:drug effects
chemical_list: D000085:Acetates; D003517:Cyclopentanes; D008070:Lipopolysaccharides; D018696:Neuroprotective Agents; D009573:Nitrites; D054883:Oxylipins; C072239:methyl jasmonate; D000110:Acetylcholinesterase
keywords: Lipopolysaccharide; Memory impairment; Methyl jasmonate; Neuroinflammation