title: Saponin-Based Nanoemulsification Improves the Antioxidant Properties of Vitamin A and E in AML-12 Cells.
abstract: Our work aimed to investigate the protective effects of saponin-based nanoemulsions of vitamin A and E against oxidative stress-induced cellular damage in AML-12 cells. Saponin nanoemulsions of vitamin A (SAN) and vitamin E (SEN) were prepared by high-pressure homogenization and characterized in terms of size, zeta potential, and polydispersity index. SEN and SAN protect AML-12 cells against oxidative stress-induced cellular damage more efficiently via scavenging reactive oxygen species (ROS), and reducing DNA damage, protein carbonylation, and lipid peroxidation. These results provide valuable information for the development of nanoemulsion-based delivery systems that would improve the antioxidant properties of vitamin A and E.
authors: Department of Food and Biotechnology, Korea University, 2511 Sejongro, Jochiwon, Sejong 339-700, Korea. qaisra@korea.ac.kr.
authors: Qaisra Naheed
authors: QN
authors: Choudhry
authors: Department of Food and Biotechnology, Korea University, 2511 Sejongro, Jochiwon, Sejong 339-700, Korea. micaella76@gmail.com.
authors: Mi Jeong
authors: MJ
authors: Kim
authors: Department of Food and Biotechnology, Korea University, 2511 Sejongro, Jochiwon, Sejong 339-700, Korea. summermoon@korea.ac.kr.
authors: Tae Gyun
authors: TG
authors: Kim
authors: Department of Food and Biotechnology, Korea University, 2511 Sejongro, Jochiwon, Sejong 339-700, Korea. jh_pan@korea.ac.kr.
authors: Jeong Hoon
authors: JH
authors: Pan
authors: Department of Food and Biotechnology, Korea University, 2511 Sejongro, Jochiwon, Sejong 339-700, Korea. phillip@korea.ac.kr.
authors: Jun Ho
authors: JH
authors: Kim
authors: Department of Food and Biotechnology, Korea University, 2511 Sejongro, Jochiwon, Sejong 339-700, Korea. timothypsj@hanmail.net.
authors: Sung Jin
authors: SJ
authors: Park
authors: Department of Food and Biotechnology, Korea University, 2511 Sejongro, Jochiwon, Sejong 339-700, Korea. jinhyuplee@korea.ac.kr.
authors: Jin Hyup
authors: JH
authors: Lee
authors: Department of Food and Biotechnology, Korea University, 2511 Sejongro, Jochiwon, Sejong 339-700, Korea. yk46@korea.ac.kr.
authors: Young Jun
authors: YJ
authors: Kim
mesh_terms: D000975:Antioxidants / Q000737:chemistry* / Q000494:pharmacology*; D004655:Emulsions / Q000737:chemistry*; D022781:Hepatocytes / Q000187:drug effects / Q000378:metabolism; D006801:Humans; D006861:Hydrogen Peroxide / Q000494:pharmacology*; D049329:Nanostructures / Q000737:chemistry*; D018384:Oxidative Stress / Q000187:drug effects; D017382:Reactive Oxygen Species / Q000378:metabolism; D012503:Saponins / Q000737:chemistry*; D014801:Vitamin A / Q000737:chemistry* / Q000494:pharmacology*; D014810:Vitamin E / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: D000975:Antioxidants; D004655:Emulsions; D017382:Reactive Oxygen Species; D012503:Saponins; D014801:Vitamin A; D014810:Vitamin E; D006861:Hydrogen Peroxide
keywords: antioxidant capacity; nanoemulsification; saponin; vitamin A; vitamin E