title: Oxidative Stress Implications in the Affective Disorders: Main Biomarkers, Animal Models Relevance, Genetic Perspectives, and Antioxidant Approaches.
abstract: The correlation between the affective disorders and the almost ubiquitous pathological oxidative stress can be described in a multifactorial way, as an important mechanism of central nervous system impairment. Whether the obvious changes which occur in oxidative balance of the affective disorders are a part of the constitutive mechanism or a collateral effect yet remains as an interesting question. However it is now clear that oxidative stress is a component of these disorders, being characterized by different aspects in a disease-dependent manner. Still, there are a lot of controversies regarding the relevance of the oxidative stress status in most of the affective disorders and despite the fact that most of the studies are showing that the affective disorders development can be correlated to increased oxidative levels, there are various studies stating that oxidative stress is not linked with the mood changing tendencies. Thus, in this minireview we decided to describe the way in which oxidative stress is involved in the affective disorders development, by focusing on the main oxidative stress markers that could be used mechanistically and therapeutically in these deficiencies, the genetic perspectives, some antioxidant approaches, and the relevance of some animal models studies in this context.
authors: Department of Molecular and Experimental Biology, "Alexandru Ioan Cuza" University, 11 Carol I, 700506 Iaşi, Romania.
authors: Ioana Miruna
authors: IM
authors: Balmus
authors: Romanian Academy, Iasi Branch, 8 Carol I, 700505 Iaşi, Romania; "Grigore T. Popa" University of Medicine and Pharmacy, 16 Universitatii Street, 700115 Iasi, Romania.
authors: Alin
authors: 0000-0002-1750-6011
authors: A
authors: Ciobica
authors: Department of Molecular and Experimental Biology, "Alexandru Ioan Cuza" University, 11 Carol I, 700506 Iaşi, Romania.
authors: Iulia
authors: 0000-0002-7043-2496
authors: I
authors: Antioch
authors: "Grigore T. Popa" University of Medicine and Pharmacy, 16 Universitatii Street, 700115 Iasi, Romania.
authors: Romeo
authors: R
authors: Dobrin
authors: "Grigore T. Popa" University of Medicine and Pharmacy, 16 Universitatii Street, 700115 Iasi, Romania.
authors: Daniel
authors: D
authors: Timofte
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use*; D015415:Biomarkers / Q000378:metabolism*; D004195:Disease Models, Animal; D006801:Humans; D019964:Mood Disorders / Q000188:drug therapy / Q000235:genetics* / Q000473:pathology*; D018384:Oxidative Stress / Q000235:genetics*
chemical_list: D000975:Antioxidants; D015415:Biomarkers