title: Impact of 2, 3, 5, 4'-tetrahydroxystilbene-2-O-β-D-glucoside on cognitive deficits in animal models of Alzheimer's disease: a systematic review.
abstract: BACKGROUND
  The efficacy of 2, 3, 5, 4'-tetrahydroxystilbene-2-O-β-D-glucoside (TSG) treatment on cognitive decline in individuals with Alzheimer's disease (AD) has not been investigated. Therefore, we systematically reviewed the effect of TSG on cognitive deficits in a rodent model of AD.
  
  
  METHODS
  We identified eligible studies published from January 1980 to April 2015 by searching seven electronic databases. We assessed the study quality, evaluated the efficacy of TSG treatment, and performed a stratified meta-analysis and meta-regression analysis to assess the influence of study design on TSG efficacy.
  
  
  RESULTS
  Among a total of 381 publications, 18 fulfilled our inclusion criteria. The overall methodological quality of these studies was poor. The meta-analysis revealed a statistically significant benefit of TSG on acquisition memory (standardized mean difference [SMD] = -1.46 (95 % CI: -1.81 to -1.10, P < 0.0001) and retention memory (SMD =1.93 (95 % CI: 1.40 to 2.46, P < 0.0001) in experimental models of AD. The stratified analysis revealed a significantly higher effect size for both acquisition and retention memory in studies that used mixed sex models and a significantly higher effect size for acquisition memory in studies that used transgenic models.
  
  
  CONCLUSIONS
  Our meta-analysis highlights a significantly better treatment effect in rodent AD models that received TSG that in those that did not. These findings indicate a potential therapeutic role of TSG in AD therapy. However, additional well-designed and detailed experimental studies are needed to evaluate the safety of TSG.
authors: Department of Integrated Traditional Chinese & Western Medicine, The Second Xiangya Hospital, Central South University, No.139 Middle Renmin Road, Changsha, Hunan, 410011, People's Republic of China.|Department of Integrated Traditional Chinese & Western Medicine, Xiangya Hospital, Central South University, Changsha, 410008, China.
authors: Chenxia
authors: C
authors: Sheng
authors: Department of Integrated Traditional Chinese & Western Medicine, The Second Xiangya Hospital, Central South University, No.139 Middle Renmin Road, Changsha, Hunan, 410011, People's Republic of China.
authors: Weijun
authors: W
authors: Peng
authors: Department of Integrated Traditional Chinese & Western Medicine, Xiangya Hospital, Central South University, Changsha, 410008, China.
authors: Zeqi
authors: Z
authors: Chen
authors: Department of Integrated Traditional Chinese & Western Medicine, The Second Xiangya Hospital, Central South University, No.139 Middle Renmin Road, Changsha, Hunan, 410011, People's Republic of China.
authors: Yucheng
authors: Y
authors: Cao
authors: Department of Integrated Traditional Chinese & Western Medicine, The Second Xiangya Hospital, Central South University, No.139 Middle Renmin Road, Changsha, Hunan, 410011, People's Republic of China.
authors: Wei
authors: W
authors: Gong
authors: Department of Integrated Traditional Chinese & Western Medicine, The Second Xiangya Hospital, Central South University, No.139 Middle Renmin Road, Changsha, Hunan, 410011, People's Republic of China.
authors: Zi-An
authors: ZA
authors: Xia
authors: Department of Integrated Traditional Chinese & Western Medicine, Xiangya Hospital, Central South University, Changsha, 410008, China.
authors: Yang
authors: Y
authors: Wang
authors: Department of Integrated Traditional Chinese & Western Medicine, The Second Xiangya Hospital, Central South University, No.139 Middle Renmin Road, Changsha, Hunan, 410011, People's Republic of China.
authors: Nanxiang
authors: N
authors: Su
authors: Department of Integrated Traditional Chinese & Western Medicine, The Second Xiangya Hospital, Central South University, No.139 Middle Renmin Road, Changsha, Hunan, 410011, People's Republic of China. ericwangzhe@126.com.
authors: Zhe
authors: Z
authors: Wang
mesh_terms: D000544:Alzheimer Disease; D000818:Animals; D003071:Cognition / Q000187:drug effects*; D004195:Disease Models, Animal; D005960:Glucosides / Q000494:pharmacology*; D006801:Humans; D051379:Mice; D051381:Rats; D013267:Stilbenes / Q000494:pharmacology*
chemical_list: C489707:2',3',4',5'-tetrahydroxystilbene-2-O-beta-D-glucoside; D005960:Glucosides; D013267:Stilbenes
keywords: 2, 3, 5, 4′-tetrahydroxystilbene-2-O-β-D-glucoside; Alzheimer’s disease; Cognitive deficits; Systematic review