title: Prognosis and management of adult wild type gastrointestinal stromal tumours (GISTs): A pooled analysis and review of literature.
abstract: A pooled review was performed to determine survival in adult WT GIST (Wild Type GastroIntestinal Stromal Tumours) and compare the same with pediatric WT GISTs. Electronic databases were searched using the terms "Wild type" AND "GIST". Eighty-two adult patients from 14 studies were included in the pooled analysis. Cumulative survival was greater than 50% in both age groups, hence medial survival could not be computed. Mean survival in adults was 15.7 years ± 0.78 and in children was 18.8 years ± 1.3 (p = 0.241). Median disease free survival in adults was 10 years while 5-year overall survival was 88%. There was no statistically significant difference in the survival between the two groups (p = 0.241). Overall survival in adults with WT GISTs is favourable compared to other adult GIST subtypes likely reflects a common molecular pathway similar to pediatric GIST.
authors: Department of Surgery, Tallaght Hospital, Dublin, Ireland.
authors: N R
authors: NR
authors: Bhatt
authors: Department of Surgery, Tallaght Hospital, Dublin, Ireland.
authors: D
authors: D
authors: Collins
authors: Department of Pathology, Tallaght Hospital, Dublin, Ireland.
authors: P
authors: P
authors: Crotty
authors: Department of Surgery, Tallaght Hospital, Dublin, Ireland. Electronic address: ridgwayp@tcd.ie.
authors: P F
authors: PF
authors: Ridgway
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003131:Combined Modality Therapy; D019468:Disease Management; D005260:Female; D005770:Gastrointestinal Neoplasms / Q000473:pathology / Q000628:therapy*; D046152:Gastrointestinal Stromal Tumors / Q000473:pathology / Q000628:therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011379:Prognosis; D015996:Survival Rate; D055815:Young Adult
keywords: Gastrointestinal stromal tumour; Management; Prognosis; Wild-type