title: Allylic Alkylations with Enamine Nucleophiles.
abstract: Allylic alkylation reactions are some of the most important carbon-carbon bond forming reactions in organic synthesis. In particular, the alkylation of carbonyl substrates provides an efficient pathway to structurally diverse molecules. Such reactions predominantly rely on the in situ generation of a nucleophilic enamine intermediate. This brief personal account describes research carried out in our group concerning the Pd-catalyzed allylic alkylation of carbonyl compounds using these species. Our methodology combines Pd-catalysis with metallocene ligands to carry out these transformations.
authors: School of Pharmacy, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, P. R. China.
authors: Nicholas
authors: N
authors: Butt
authors: School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, P. R. China.
authors: Guoqiang
authors: G
authors: Yang
authors: School of Pharmacy, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, P. R. China.|School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, P. R. China.
authors: Wanbin
authors: W
authors: Zhang
keywords: allylic alkylation; carbonyl compounds; enamines; metallocene ligands; palladium