title: Synthesis of (125) I-lamivudine and (125) I-lamivudine-ursodeoxycholic acid codrug.
abstract: The preparation of (125) I-lamivudine ((125) I-3TC) and (125) I-lamivudine-ursodeoxycholic acid codrug ((125) I-3TC-UDCA), suitable for comparative biodistribution studies, is described. The synthesis of the unlabeled precursor 3TC-UDCA proceeds in an 11.6% yield, and the radiolabelling yields for (125) I-3TC and (125) I-3TC-UDCA were 89 and 92%, respectively. The final products are radiochemically pure (greater than 98%).
authors: Labelled Compounds Department, Hot Labs Centre, Atomic Energy Authority, Cairo, 13759, Egypt. mamotaleb10@yahoo.com.
authors: M A
authors: MA
authors: Motaleb
authors: Department of Medicinal Chemistry, Faculty of Pharmacy, Zagazig University, 44519, Zagazig, Egypt.
authors: M
authors: M
authors: Abo-Kul
authors: Department of Medicinal Chemistry, Faculty of Pharmacy, Zagazig University, 44519, Zagazig, Egypt.
authors: Samy M
authors: SM
authors: Ibrahim
authors: Cyclotron Project, Nuclear Research Centre, Atomic Energy Authority, Cairo, 13759, Egypt.
authors: Shokry M
authors: SM
authors: Saad
authors: Cyclotron Project, Nuclear Research Centre, Atomic Energy Authority, Cairo, 13759, Egypt.
authors: Muhammad
authors: M
authors: Arafat
mesh_terms: D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000737:chemistry*; D060326:Chemistry Techniques, Synthetic; D007457:Iodine Radioisotopes / Q000737:chemistry*; D019259:Lamivudine / Q000138:chemical synthesis* / Q000737:chemistry*; D011854:Radiochemistry; D014580:Ursodeoxycholic Acid / Q000737:chemistry*
chemical_list: D000998:Antiviral Agents; D007457:Iodine Radioisotopes; D019259:Lamivudine; D014580:Ursodeoxycholic Acid
keywords: codrug; hepatitis B; iodine-125; lamivudine; ursodeoxycholic acid