title: Exercise in Takayasu Arteritis: Effects on Inflammatory and Angiogenic Factors and Disease-Related Symptoms.
abstract: To investigate the effects of acute and chronic exercise in female patients with remissive Takayasu arteritis (TAK).
  
  
  
  This was a 2-part prospective study. In study 1, cytokines and soluble tumor necrosis factor (TNF) receptors were assessed at rest and every 60 minutes during a 3-hour recovery period following an acute exercise session in TAK (n = 11) and heathy control (n = 10) groups. In study 2, a subsample from the TAK group (n = 6) underwent a 12-week exercise training program. Before and after training, the acute session of aerobic exercise was performed and cytokines and soluble TNF receptors were assessed at the same time points described above. Muscle function, strength, aerobic capacity, endothelial function, quality of life, and walking impairment scores were evaluated.
  
  
  
  In study 1, the acute session of aerobic exercise led to overall similar responses on cytokine kinetics in the TAK and heathy control groups. In study 2, the exercise training program did not exacerbate inflammatory cytokines in TAK patients, while the proinflammatory cytokine TNF was diminished both at rest and following the acute session of aerobic exercise. In addition, the exercise training program increased the pro-angiogenic factors vascular endothelial growth factor (at rest) and platelet-derived growth factor AA (at rest and in response to the acute session of aerobic exercise). The exercise training program improved muscle strength and function, whereas aerobic capacity, quality of life, and endothelial function parameters remained unchanged.
  
  
  
  Exercise could be a well-tolerated, safe, and effective intervention able to induce immunomodulatory and pro-angiogenic effects and to increase strength and function in patients with TAK.
authors: School of Medicine, University of Sao Paulo, Sao Paulo, Brazil.
authors: Diego S
authors: DS
authors: Oliveira
authors: School of Medicine, University of Sao Paulo, Sao Paulo, Brazil.
authors: Samuel K
authors: SK
authors: Shinjo
authors: School of Medicine, University of Sao Paulo, Sao Paulo, Brazil.
authors: Marilda G
authors: MG
authors: Silva
authors: School of Medicine, University of Sao Paulo, Sao Paulo, Brazil.
authors: Ana L
authors: AL
authors: de Sá-Pinto
authors: School of Medicine, University of Sao Paulo, Sao Paulo, Brazil.
authors: Fernanda R
authors: FR
authors: Lima
authors: School of Medicine, University of Sao Paulo, Sao Paulo, Brazil.
authors: Hamilton
authors: H
authors: Roschel
authors: School of Medicine, University of Sao Paulo, Sao Paulo, Brazil.
authors: Suzana B V
authors: SBV
authors: Mello
authors: School of Medicine, University of Sao Paulo, Sao Paulo, Brazil.
authors: Valéria
authors: V
authors: Costa-Hong
authors: School of Medicine, University of Sao Paulo, Sao Paulo, Brazil.
authors: Maria C C
authors: MCC
authors: Irigoyen
authors: School of Medicine, University of Sao Paulo, Sao Paulo, Brazil.
authors: Rosa M
authors: RM
authors: Pereira
authors: School of Medicine, University of Sao Paulo, Sao Paulo, Brazil.
authors: Bruno
authors: B
authors: Gualano
mesh_terms: D000328:Adult; D015444:Exercise / Q000502:physiology*; D005080:Exercise Test / Q000379:methods; D005260:Female; D006801:Humans; D018836:Inflammation Mediators / Q000097:blood*; D009389:Neovascularization, Pathologic / Q000097:blood / Q000503:physiopathology / Q000628:therapy; D011446:Prospective Studies; D013625:Takayasu Arteritis / Q000097:blood* / Q000503:physiopathology / Q000628:therapy*; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D018836:Inflammation Mediators