title: How could fully scaled carps appear in natural waters in Madagascar?
abstract: The capacity of organisms to rapidly evolve in response to environmental changes is a key feature of evolution, and studying mutation compensation is a way to evaluate whether alternative routes of evolution are possible or not. Common carps (Cyprinus carpio) carrying a homozygous loss-of-function mutation for the scale cover gene fgfr1a1, causing the 'mirror' reduced scale cover, were introduced in Madagascar a century ago. Here we show that carps in Malagasy natural waters are now predominantly covered with scales, though they still all carry the homozygous mutation. We also reveal that the number of scales in mutated carps is under strong polygenic genetic control, with a heritability of 0.49. As a whole, our results suggest that carps submitted to natural selection could evolve a wild-type-like scale cover in less than 40 generations from standing polygenic genetic variation, confirming similar findings mainly retrieved from model organisms.
authors: GABI, INRA, AgroParisTech, Université Paris-Saclay, 78350 Jouy-en-Josas, France.
authors: Jean-Noël
authors: 0000-0001-8564-1429
authors: JN
authors: Hubert
authors: Ifremer, UMR 9190 MARBEC, 34250 Palavas-les-Flots, France.
authors: François
authors: 0000-0002-8232-904X
authors: F
authors: Allal
authors: GABI, INRA, AgroParisTech, Université Paris-Saclay, 78350 Jouy-en-Josas, France.
authors: Caroline
authors: C
authors: Hervet
authors: FOFIFA, DRZV, Antananarivo, Madagascar.
authors: Monique
authors: 0000-0002-6447-2467
authors: M
authors: Ravakarivelo
authors: NAIK HAKI, 5540 Szarvas, Hungary.
authors: Zsigmond
authors: 0000-0003-4670-2705
authors: Z
authors: Jeney
authors: Ifremer, 34250 Palavas-les-Flots, France.
authors: Alain
authors: 0000-0001-8748-6426
authors: A
authors: Vergnet
authors: GABI, INRA, AgroParisTech, Université Paris-Saclay, 78350 Jouy-en-Josas, France.
authors: René
authors: 0000-0003-2816-6398
authors: R
authors: Guyomard
authors: GABI, INRA, AgroParisTech, Université Paris-Saclay, 78350 Jouy-en-Josas, France Ifremer, 34250 Palavas-les-Flots, France marc.vandeputte@jouy.inra.fr.
authors: Marc
authors: 0000-0001-9929-4587
authors: M
authors: Vandeputte
mesh_terms: D000075342:Animal Scales; D000818:Animals; D005075:Biological Evolution; D002347:Carps; D014644:Genetic Variation; D005838:Genotype; D008270:Madagascar; D012641:Selection, Genetic
keywords: evolution; heritability; mutation compensation