title: Association study of dopamine receptor genes polymorphisms with the risk of schizophrenia in the Han Chinese population.
abstract: Schizophrenia is a highly heritable psychiatric disorder often associated with dopamine-related genetic variations. Thus, we performed a case-control study in 1504 Han Chinese population to evaluate the association of DRD1, DRD2 and DRD3 polymorphisms with schizophrenia. No statistically significant difference in allelic or genotypic frequency was found between schizophrenia and control subjects. Strong positive linkage disequilibrium was detected among the SNPs within DRD1 and DRD2. However, no positive haplotype distribution was found to be associated with schizophrenia. Our results indicated that DRD1, DRD2 and DRD3 may not be the susceptibility genes for schizophrenia in the Chinese Han population.
authors: Bio-X Institutes, Key Laboratory for the Genetics of Development and Neuropsychiatric Disorders, Ministry of Education, Shanghai Jiao Tong University, 1954 Huashan Road, Shanghai 200030, China; Institute for Nutritional Sciences, Shanghai Institutes of Biological Sciences, Chinese Academy of Sciences, 320 Yueyang Road, Shanghai 200031, China.
authors: Beimeng
authors: B
authors: Yang
authors: Bio-X Institutes, Key Laboratory for the Genetics of Development and Neuropsychiatric Disorders, Ministry of Education, Shanghai Jiao Tong University, 1954 Huashan Road, Shanghai 200030, China; Institute for Nutritional Sciences, Shanghai Institutes of Biological Sciences, Chinese Academy of Sciences, 320 Yueyang Road, Shanghai 200031, China.
authors: Weibo
authors: W
authors: Niu
authors: Bio-X Institutes, Key Laboratory for the Genetics of Development and Neuropsychiatric Disorders, Ministry of Education, Shanghai Jiao Tong University, 1954 Huashan Road, Shanghai 200030, China; Institute for Nutritional Sciences, Shanghai Institutes of Biological Sciences, Chinese Academy of Sciences, 320 Yueyang Road, Shanghai 200031, China.
authors: Shiqing
authors: S
authors: Chen
authors: Bio-X Institutes, Key Laboratory for the Genetics of Development and Neuropsychiatric Disorders, Ministry of Education, Shanghai Jiao Tong University, 1954 Huashan Road, Shanghai 200030, China; Institute for Nutritional Sciences, Shanghai Institutes of Biological Sciences, Chinese Academy of Sciences, 320 Yueyang Road, Shanghai 200031, China.
authors: Fei
authors: F
authors: Xu
authors: Bio-X Institutes, Key Laboratory for the Genetics of Development and Neuropsychiatric Disorders, Ministry of Education, Shanghai Jiao Tong University, 1954 Huashan Road, Shanghai 200030, China; Institute for Nutritional Sciences, Shanghai Institutes of Biological Sciences, Chinese Academy of Sciences, 320 Yueyang Road, Shanghai 200031, China.
authors: Xingwang
authors: X
authors: Li
authors: Bio-X Institutes, Key Laboratory for the Genetics of Development and Neuropsychiatric Disorders, Ministry of Education, Shanghai Jiao Tong University, 1954 Huashan Road, Shanghai 200030, China; Institute for Nutritional Sciences, Shanghai Institutes of Biological Sciences, Chinese Academy of Sciences, 320 Yueyang Road, Shanghai 200031, China.
authors: Xi
authors: X
authors: Wu
authors: Bio-X Institutes, Key Laboratory for the Genetics of Development and Neuropsychiatric Disorders, Ministry of Education, Shanghai Jiao Tong University, 1954 Huashan Road, Shanghai 200030, China; Institute for Nutritional Sciences, Shanghai Institutes of Biological Sciences, Chinese Academy of Sciences, 320 Yueyang Road, Shanghai 200031, China.
authors: Yanfei
authors: Y
authors: Cao
authors: Bio-X Institutes, Key Laboratory for the Genetics of Development and Neuropsychiatric Disorders, Ministry of Education, Shanghai Jiao Tong University, 1954 Huashan Road, Shanghai 200030, China; Institute for Nutritional Sciences, Shanghai Institutes of Biological Sciences, Chinese Academy of Sciences, 320 Yueyang Road, Shanghai 200031, China.
authors: Rui
authors: R
authors: Zhang
authors: Bio-X Institutes, Key Laboratory for the Genetics of Development and Neuropsychiatric Disorders, Ministry of Education, Shanghai Jiao Tong University, 1954 Huashan Road, Shanghai 200030, China; Institute for Nutritional Sciences, Shanghai Institutes of Biological Sciences, Chinese Academy of Sciences, 320 Yueyang Road, Shanghai 200031, China.
authors: Fengping
authors: F
authors: Yang
authors: Bio-X Institutes, Key Laboratory for the Genetics of Development and Neuropsychiatric Disorders, Ministry of Education, Shanghai Jiao Tong University, 1954 Huashan Road, Shanghai 200030, China; Institute for Nutritional Sciences, Shanghai Institutes of Biological Sciences, Chinese Academy of Sciences, 320 Yueyang Road, Shanghai 200031, China.
authors: Lu
authors: L
authors: Wang
authors: Bio-X Institutes, Key Laboratory for the Genetics of Development and Neuropsychiatric Disorders, Ministry of Education, Shanghai Jiao Tong University, 1954 Huashan Road, Shanghai 200030, China; Institute for Nutritional Sciences, Shanghai Institutes of Biological Sciences, Chinese Academy of Sciences, 320 Yueyang Road, Shanghai 200031, China.
authors: Weidong
authors: W
authors: Li
authors: Shanghai Key Laboratory of Psychotic Disorders, Shanghai Institute of Mental Health, Shanghai Jiao Tong University, 600 South Wan Ping Road, Shanghai 200030, China.
authors: Yifeng
authors: Y
authors: Xu
authors: Bio-X Institutes, Key Laboratory for the Genetics of Development and Neuropsychiatric Disorders, Ministry of Education, Shanghai Jiao Tong University, 1954 Huashan Road, Shanghai 200030, China; Wuxi Mental Health Center, 156 Qian Rong Road, Wuxi 214151, China; Institute for Nutritional Sciences, Shanghai Institutes of Biological Sciences, Chinese Academy of Sciences, 320 Yueyang Road, Shanghai 200031, China.
authors: Lin
authors: L
authors: He
authors: Bio-X Institutes, Key Laboratory for the Genetics of Development and Neuropsychiatric Disorders, Ministry of Education, Shanghai Jiao Tong University, 1954 Huashan Road, Shanghai 200030, China. Electronic address: heguang@sjtu.edu.cn.
authors: Guang
authors: G
authors: He
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D002681:China; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D017447:Receptors, Dopamine D1 / Q000235:genetics*; D017448:Receptors, Dopamine D2 / Q000235:genetics*; D050637:Receptors, Dopamine D3 / Q000235:genetics*; D012306:Risk; D012559:Schizophrenia / Q000235:genetics*
chemical_list: C583260:DRD1 protein, human; C581293:DRD2 protein, human; C493593:DRD3 protein, human; D017447:Receptors, Dopamine D1; D017448:Receptors, Dopamine D2; D050637:Receptors, Dopamine D3
keywords: DRD1; DRD2; DRD3