title: Development of a voltage-dependent current noise algorithm for conductance-based stochastic modelling of auditory nerve fibres.
abstract: This study presents the development of an alternative noise current term and novel voltage-dependent current noise algorithm for conductance-based stochastic auditory nerve fibre (ANF) models. ANFs are known to have significant variance in threshold stimulus which affects temporal characteristics such as latency. This variance is primarily caused by the stochastic behaviour or microscopic fluctuations of the node of Ranvier's voltage-dependent sodium channels of which the intensity is a function of membrane voltage. Though easy to implement and low in computational cost, existing current noise models have two deficiencies: it is independent of membrane voltage, and it is unable to inherently determine the noise intensity required to produce in vivo measured discharge probability functions. The proposed algorithm overcomes these deficiencies while maintaining its low computational cost and ease of implementation compared to other conductance and Markovian-based stochastic models. The algorithm is applied to a Hodgkin-Huxley-based compartmental cat ANF model and validated via comparison of the threshold probability and latency distributions to measured cat ANF data. Simulation results show the algorithm's adherence to in vivo stochastic fibre characteristics such as an exponential relationship between the membrane noise and transmembrane voltage, a negative linear relationship between the log of the relative spread of the discharge probability and the log of the fibre diameter and a decrease in latency with an increase in stimulus intensity.
authors: Department of Electrical, Electronic and Computer Engineering, University of Pretoria, Lynnwood Road, Pretoria, 0002, South Africa. werner.badenhorst@up.ac.za.
authors: Werner
authors: 0000-0003-2387-1100
authors: W
authors: Badenhorst
authors: Department of Electrical, Electronic and Computer Engineering, University of Pretoria, Lynnwood Road, Pretoria, 0002, South Africa.
authors: Tania
authors: T
authors: Hanekom
authors: Department of Electrical, Electronic and Computer Engineering, University of Pretoria, Lynnwood Road, Pretoria, 0002, South Africa.
authors: Johan J
authors: JJ
authors: Hanekom
mesh_terms: D000465:Algorithms; D000818:Animals; D003056:Cochlear Nerve / Q000502:physiology*; D008959:Models, Neurological; D009412:Nerve Fibers; D009622:Noise
keywords: Conductance-based; Current noise; Hodgkin–Huxley; Relative spread; Stochastic auditory nerve fibre model