title: Peripapillary Pachychoroid in Nonarteritic Anterior Ischemic Optic Neuropathy.
abstract: This study examined the peripapillary choroidal thickness (PCT) in nonarteritic ischemic optic neuropathy (NAION) in comparison to contralateral eyes and normal eyes.
  
  
  
  We used enhanced depth imaging spectral-domain optical coherence tomography to image the optic nerve head of 20 NAION, 10 contralateral eyes, and 102 normal eyes. Following compensation, the scans were manually delineated to identify relevant surfaces including Bruch's membrane opening (BMO), Bruch's membrane, and anterior sclera. The PCT was defined as the measurement between Bruch's membrane and the anterior sclera and was measured at increasing distance from BMO. Models adjusted for age, BMO area, and axial length were used to compare the mean PCT between NAION and normal eyes, and contralateral eyes and normal eyes. Paired t-tests were used to compare the PCT between NAION and contralateral eyes.
  
  
  
  The mean PCT was thicker in NAION and contralateral eyes when compared with normal eyes at all distances from BMO (P < 0.001). The PCT was not significantly thicker in contralateral eyes when compared with affected NAION eyes. Choroidal thickness was thinnest in the inferior quadrant in all eyes regardless of the group.
  
  
  
  Increased peripapillary choroidal thickness was noted in both NAION and contralateral eyes. The thicker choroid may be an associated feature or a result of the disorder. Although further longitudinal study is required to determine causation, these findings may suggest that a thickened peripapillary choroid may be a component of the disk-at-risk clinical phenotype.
authors: Department of Ophthalmology School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, United States.
authors: Lina
authors: L
authors: Nagia
authors: Department of Ophthalmology School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, United States.
authors: Carrie
authors: C
authors: Huisingh
authors: Department of Computer and Information Sciences, Colleges of Arts and Sciences, University of Alabama at Birmingham, Birmingham, Alabama, United States.
authors: John
authors: J
authors: Johnstone
authors: Department of Ophthalmology School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, United States.
authors: Lanning B
authors: LB
authors: Kline
authors: Department of Ophthalmology School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, United States.
authors: Mark
authors: M
authors: Clark
authors: In Vivo Biomechanics Laboratory, Department of Biomedical Engineering, National University of Singapore, Singapore, Singapore 4Singapore Eye Research Institute, Singapore National Eye Center, Singapore, Singapore.
authors: Michael J A
authors: MJ
authors: Girard
authors: GePaSud, Université de la Polynésie Française, Punaauia, Tahiti, French Polynesia.
authors: Jean Martial
authors: JM
authors: Mari
authors: Department of Ophthalmology School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, United States.
authors: Christopher A
authors: CA
authors: Girkin
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002829:Choroid / Q000473:pathology*; D018450:Disease Progression; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009898:Optic Disk / Q000473:pathology*; D018917:Optic Neuropathy, Ischemic / Q000175:diagnosis*; D012189:Retrospective Studies; D041623:Tomography, Optical Coherence / Q000379:methods*; D014792:Visual Acuity