title: Pancreatic Hepatoid Carcinoma Mimicking a Solid Pseudopapillary Neoplasm: A Challenging Case on Endoscopic Ultrasound-guided Fine-needle Aspiration.
abstract: A 59-year-old man was admitted to our hospital for treatment of a 45 mm pancreatic mass found during a medical examination. Endoscopic ultrasound-guided fine-needle aspiration cytology showed polygonal cells with pseudopapillary structures. The tumor cells were positive for nuclear/cytoplasmic β-catenin and CD10, and negative for chromogranin A. After a tentative diagnosis of a solid pseudopapillary neoplasm, middle pancreatectomy was performed. Histologically, polygonal cells with abundant eosinophilic cytoplasm formed in the trabeculae and were immunohistochemically positive for HepPar1 and protein induced by vitamin K absence or antagonist-II. The tumor was finally diagnosed to be pancreatic hepatoid carcinoma. No recurrence occurred for 12 months, even without adjuvant chemotherapy.
authors: Department of Gastroenterology & Hepatology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Japan.
authors: Yutaka
authors: Y
authors: Akimoto
authors: Hironari
authors: H
authors: Kato
authors: Kazuyuki
authors: K
authors: Matsumoto
authors: Ryo
authors: R
authors: Harada
authors: Shinsuke
authors: S
authors: Oda
authors: Soichiro
authors: S
authors: Fushimi
authors: Shou
authors: S
authors: Mizukawa
authors: Shuntaro
authors: S
authors: Yabe
authors: Daisuke
authors: D
authors: Uchida
authors: Hiroyuki
authors: H
authors: Seki
authors: Takeshi
authors: T
authors: Tomoda
authors: Naoki
authors: N
authors: Yamamoto
authors: Shigeru
authors: S
authors: Horiguchi
authors: Koichiro
authors: K
authors: Tsutsumi
authors: Takahito
authors: T
authors: Yagi
authors: Hiroyuki
authors: H
authors: Okada
mesh_terms: D000951:Antigens, Neoplasm / Q000096:biosynthesis; D002291:Carcinoma, Papillary / Q000175:diagnosis; D003937:Diagnosis, Differential; D061765:Endoscopic Ultrasound-Guided Fine Needle Aspiration; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010180:Pancreatectomy; D010190:Pancreatic Neoplasms / Q000175:diagnosis* / Q000473:pathology*; D051176:beta Catenin / Q000378:metabolism
chemical_list: D000951:Antigens, Neoplasm; C000600022:HepPar-1 protein, human; D051176:beta Catenin