title: Effects of a pre-operative home-based inspiratory muscle training programme on perceived health-related quality of life in patients undergoing coronary artery bypass graft surgery.
abstract: OBJECTIVE
  Pre-operative inspiratory muscle training has been shown to decrease the incidence of postoperative pneumonia and length of hospital stay in patients undergoing coronary artery bypass graft surgery (CABG). This study investigated if this decrease acted as a mediator on the time course of quality of life.
  
  
  METHODS
  Complementary analyses of a published randomised controlled trial.
  
  
  METHODS
  The initial trial included patients awaiting CABG surgery at a Dutch university hospital. The secondary analyses used data from the initial trial for patients who had completed at least one quality-of-life questionnaire.
  
  
  METHODS
  Participants were allocated at random to the intervention group or the usual care group. The intervention group followed a home-based pre-operative inspiratory muscle training programme. Quality of life was measured at five time points. Between-group differences in quality-of-life scores were analysed using mixed linear modelling.
  
  
  RESULTS
  The secondary analyses used data for 235 patients. In line with the initial trial, pneumonia and length of hospital stay were decreased significantly in the intervention group. The time courses for all patients showed significant improvements in quality of life after surgery compared with baseline. No significant differences in quality of life were observed over time between the two groups.
  
  
  CONCLUSIONS
  Despite decreased incidence of pneumonia and length of hospital stay in the intervention group, this study did not find any improvements in quality of life due to the pre-operative home-based inspiratory muscle training programme. Clinical trial registration number ISRCTN17691887.
authors: University Medical Centre Utrecht, Academic Hospital Utrecht, Department of Rehabilitation, Nursing Science and Sports, Utrecht, The Netherlands. Electronic address: k.valkenet@umcutrecht.nl.
authors: K
authors: K
authors: Valkenet
authors: University Medical Centre Utrecht, Academic Hospital Utrecht, Department of Rehabilitation, Nursing Science and Sports, Utrecht, The Netherlands.
authors: J C A
authors: JCA
authors: Trappenburg
authors: University Medical Centre Utrecht, Wilhelmina Children's Hospital, Department of Child Development and Exercise Centre, Utrecht, The Netherlands.
authors: E H
authors: EH
authors: Hulzebos
authors: Maastricht University, CAPHRI, and Centre for Care Technology Research, and Dutch Sector Life Sciences and Health, Maastricht, The Netherlands.
authors: N L U
authors: NLU
authors: van Meeteren
authors: University Medical Centre Utrecht, Academic Hospital Utrecht, Department of Rehabilitation, Nursing Science and Sports, Utrecht, The Netherlands.
authors: F J G
authors: FJG
authors: Backx
mesh_terms: D000368:Aged; D001945:Breathing Exercises / Q000379:methods*; D001026:Coronary Artery Bypass / Q000534:rehabilitation*; D005260:Female; D006801:Humans; D007049:Iatrogenic Disease / Q000517:prevention & control; D001239:Inhalation; D007902:Length of Stay; D008297:Male; D008875:Middle Aged; D011014:Pneumonia / Q000517:prevention & control; D011183:Postoperative Complications / Q000517:prevention & control; D057234:Preoperative Period; D011788:Quality of Life; D012132:Respiratory Muscles / Q000502:physiology; D013147:Spirometry
keywords: Coronary artery bypass graft surgery; Inspiratory muscle training; Quality of life