title: Mechanism of Action and Resistance to Daptomycin in Staphylococcus aureus and Enterococci.
abstract: Lipopeptides are natural product antibiotics that consist of a peptide core with a lipid tail with a diverse array of target organisms and mechanisms of action. Daptomycin (DAP) is an example of these compounds with specific activity against Gram-positive organisms. DAP has become increasingly important to combat infections caused by Gram-positive bacteria because of the presence of multidrug resistance in these organisms, particularly in methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant enterococci (VRE). However, emergence of resistance to DAP during therapy is a well-described phenomenon that threatens the clinical use of this antibiotic, limiting further the therapeutic options against both MRSA and VRE. This work will review the historical aspects of the development of DAP, as well as the current knowledge on its mechanism of action and pathways to resistance in a clinically relevant context.
authors: University of Texas Medical School at Houston, Department of Internal Medicine, Division of Infectious Diseases, Houston, Texas 77030.
authors: William R
authors: WR
authors: Miller
authors: Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, California 90502.|David Geffen School of Medicine at UCLA, Los Angeles, California 90095.
authors: Arnold S
authors: AS
authors: Bayer
authors: University of Texas Medical School at Houston, Department of Internal Medicine, Division of Infectious Diseases, Houston, Texas 77030.|Department of Microbiology and Molecular Genetics, Houston, Texas 77030.|Molecular Genetics and Antimicrobial Resistance Unit, Universidad El Bosque, Bogota, Colombia.|International Center for Microbial Genomics, Universidad El Bosque, Bogota, Colombia.
authors: Cesar A
authors: CA
authors: Arias
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D017576:Daptomycin / Q000494:pharmacology*; D024881:Drug Resistance, Bacterial; D006801:Humans; D055624:Methicillin-Resistant Staphylococcus aureus / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D013203:Staphylococcal Infections / Q000188:drug therapy; D065507:Vancomycin-Resistant Enterococci / Q000187:drug effects*
chemical_list: D000900:Anti-Bacterial Agents; D017576:Daptomycin