title: Long noncoding and circular RNAs in lung cancer: advances and perspectives.
abstract: Better understanding and management of lung cancer are needed. Although much has been learned from known protein coding genes, long noncoding RNAs (lncRNAs), a relatively new and fast evolving large family of transcripts, have recently generated much attention for new discoveries. LncRNAs play critical regulatory functions and are emerging as new players in tumorigenesis and phenotypic determinators of lung cancer. In this review, we highlight the latest development of lncRNAs, including circular RNAs in lung cancer. We start with well-characterized lncRNAs and circular RNAs as an oncogene or tumor suppressor and then extend our discussion on the impact of SNPs in lncRNA on its functions and lung cancer risk and the clinical applications of lncRNAs as biomarkers and therapeutic targets.
authors: Department of Epidemiology, College of Preventive Medicine, Third Military Medical University, Chongqing, People's Republic of China.
authors: Weijia
authors: W
authors: Xie
authors: Department of Epidemiology, College of Preventive Medicine, Third Military Medical University, Chongqing, People's Republic of China.
authors: Shuai
authors: S
authors: Yuan
authors: Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA.
authors: Zhifu
authors: Z
authors: Sun
authors: Department of Epidemiology, College of Preventive Medicine, Third Military Medical University, Chongqing, People's Republic of China.
authors: Yafei
authors: Y
authors: Li
mesh_terms: D000818:Animals; D014408:Biomarkers, Tumor / Q000235:genetics*; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics* / Q000473:pathology; D020641:Polymorphism, Single Nucleotide; D012313:RNA / Q000235:genetics*; D000079962:RNA, Circular; D062085:RNA, Long Noncoding / Q000235:genetics*
chemical_list: D014408:Biomarkers, Tumor; D000079962:RNA, Circular; D062085:RNA, Long Noncoding; D012313:RNA
keywords: biomarkers; circular RNA; long noncoding RNA; lung cancer; oncogenic lncRNA; tumor suppressive lncRNA