title: Current Trends in Identifying Rapidly Acting Treatments for Depression.
abstract: Traditional antidepressant medications generally take weeks-to-months to achieve effect. However, the breakthrough finding of ketamine's rapidly acting antidepressant properties has inspired a decade-and-a-half of progress towards the identification of treatments that work quickly-within hours-to-days. This paradigm-shift in the discovery of antidepressant therapies has significantly changed the current landscape of antidepressant drug development. Building on this, the current review briefly highlights the recent trends in research towards identifying rapidly-acting antidepressants. Specifically, ketamine, GLYX-13, nitrous oxide, metabotropic glutamatergic receptor modulators, scopolamine, opioid-receptor modulators, and low field magnetic stimulation are discussed.
authors: Depression Clinic and Research Program, Massachusetts General Hospital, Boston, MA, USA; Harvard Medical School, Boston, MA, USA.
authors: Dawn F
authors: DF
authors: Ionescu
authors: Depression Clinic and Research Program, Massachusetts General Hospital, Boston, MA, USA; Clinical Trials Network and Institute, Massachusetts General Hospital, Boston, MA, USA; Harvard Medical School, Boston, MA, USA.
authors: George I
authors: GI
authors: Papakostas
keywords: Depression; GLYX-13; LFMS; experimental therapeutics; kappa-opioid receptor; ketamine; major depressive disorder; metabotropic glutamatergic receptor (mGluRs) modulators; nitrous oxide; psychopharmacology; rapid treatments; scopolamine; treatment-resistant depression