title: Inter-hemispheric functional dysconnectivity mediates the association of corpus callosum degeneration with memory impairment in AD and amnestic MCI.
abstract: Evidences suggested that both corpus callosum (CC) degeneration and alternations of homotopic inter-hemispheric functional connectivity (FC) are present in Alzheimer's disease (AD). However, the associations between region-specific CC degeneration and homotopic inter-hemispheric FC and their relationships with memory deficits in AD remain uncharacterized. We hypothesized that selective CC degeneration is associated with memory impairment in AD and amnestic mild cognitive impairment (aMCI), which is mediated by homotopic inter-hemispheric functional dysconnectivity. Using structural magnetic resonance imaging (MRI) and task-free functional MRI, we assessed the CC volume and inter-hemispheric FC in 66 healthy controls, 41 aMCI and 41 AD. As expected, AD had CC degeneration and attenuated inter-hemispheric homotopic FC. Nevertheless, aMCI had relatively less severe CC degeneration (mainly in mid-anterior, central, and mid-posterior) and no reduction in inter-hemispheric homotopic FC. The degeneration of each CC sub-region was associated with specific inter-hemispheric homotopic functional disconnections in AD and aMCI. More importantly, impairment of inter-hemispheric homotopic FC partially mediated the association between CC (particularly the central and posterior parts) degeneration and memory deficit. Notably, these results remained after controlling for hippocampal volume. Our findings shed light on how CC degeneration and the related inter-hemispheric FC impact memory impairment in early stage of AD.
authors: Center for Cognitive Neuroscience, Neuroscience and Behavioral Disorders Program, Duke-National University of Singapore Graduate Medical School, Singapore.
authors: Yingwei
authors: Y
authors: Qiu
authors: Center for Cognitive Neuroscience, Neuroscience and Behavioral Disorders Program, Duke-National University of Singapore Graduate Medical School, Singapore.
authors: Siwei
authors: S
authors: Liu
authors: Department of Pharmacology, National University Health System, Clinical Research Centre, Singapore.|Memory Aging &Cognition Centre, National University Health System, Singapore.
authors: Saima
authors: S
authors: Hilal
authors: Center for Cognitive Neuroscience, Neuroscience and Behavioral Disorders Program, Duke-National University of Singapore Graduate Medical School, Singapore.
authors: Yng Miin
authors: YM
authors: Loke
authors: Memory Aging &Cognition Centre, National University Health System, Singapore.|Duke-NUS Graduate Medical School, National University of Singapore, Singapore.
authors: Mohammad Kamran
authors: MK
authors: Ikram
authors: Department of Pharmacology, National University Health System, Clinical Research Centre, Singapore.|Memory Aging &Cognition Centre, National University Health System, Singapore.
authors: Xin
authors: X
authors: Xu
authors: St. Luke's Hospital, Singapore.
authors: Boon
authors: B
authors: Yeow Tan
authors: Raffles Neuroscience Centre, Raffles Hospital, Singapore.
authors: Narayanaswamy
authors: N
authors: Venketasubramanian
authors: Department of Pharmacology, National University Health System, Clinical Research Centre, Singapore.|Memory Aging &Cognition Centre, National University Health System, Singapore.
authors: Christopher Li-Hsian
authors: CL
authors: Chen
authors: Center for Cognitive Neuroscience, Neuroscience and Behavioral Disorders Program, Duke-National University of Singapore Graduate Medical School, Singapore.|Clinical Imaging Research Centre, the Agency for Science, Technology and Research and National University of Singapore, Singapore.
authors: Juan
authors: J
authors: Zhou
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000000981:diagnostic imaging* / Q000473:pathology / Q000503:physiopathology; D016022:Case-Control Studies; D060825:Cognitive Dysfunction / Q000000981:diagnostic imaging* / Q000473:pathology / Q000503:physiopathology; D063132:Connectome / Q000379:methods; D003337:Corpus Callosum / Q000000981:diagnostic imaging* / Q000473:pathology / Q000503:physiopathology; D056324:Diffusion Tensor Imaging; D005260:Female; D006624:Hippocampus / Q000000981:diagnostic imaging* / Q000473:pathology / Q000503:physiopathology; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008569:Memory Disorders / Q000000981:diagnostic imaging* / Q000473:pathology / Q000503:physiopathology; D009434:Neural Pathways / Q000000981:diagnostic imaging* / Q000473:pathology / Q000503:physiopathology; D009483:Neuropsychological Tests