title: Characterisation of CorGlaes(®) Pure 107 fibres for biomedical applications.
abstract: A degradable ultraphosphate (55 mol % P2O5) quinternary phosphate glass composition has been characterised in terms of its chemical, mechanical and degradation properties both as a bulk material and after drawing into fibres. This glass formulation displayed a large processing window simplifying fibre drawing. The fibres displayed stiffness and strength of 65.5 ± 20.8 GPa and 426±143 MPa. While amorphous discs of the glass displayed a linear dissolution rate of 0.004 mg cm(-2) h(-1) at 37 °C, in a static solution with a reduction in media pH. Once drawn into fibres, the dissolution process dropped the pH to <2 in distilled water, phosphate buffer saline and corrected-simulated body fluid, displaying an autocatalytic effect with >90 % mass loss in 4 days, about seven times faster than anticipated for this solution rate. Only cell culture media was able to buffer the pH taking over a week for full fibre dissolution, however, still four times faster dissolution rate than as a bulk material. However, at early times the development of a HCA layer was seen indicating potential bioactivity. Thus, although initial analysis indicated potential orthopaedic implant applications, autocatalysis leads to accelerating degradation in vitro.
authors: Biomedical Engineering Division, School of Engineering, University of Glasgow, Glasgow, G12 8QQ, UK.|Present address: Scottish Enterprise, Glasgow, G2 8LU, UK.
authors: Ross
authors: R
authors: Colquhoun
authors: Biomedical Engineering Division, School of Engineering, University of Glasgow, Glasgow, G12 8QQ, UK.
authors: Nikolaj
authors: N
authors: Gadegaard
authors: Giltech Ltd, 12 North Harbour St, Ayr, KA8 8BN, UK.|Present address: IDP Services Ltd., Ayr, KA7 4EG, UK.
authors: David M
authors: DM
authors: Healy
authors: Biomedical Engineering Division, School of Engineering, University of Glasgow, Glasgow, G12 8QQ, UK. elizabeth.tanner@glasgow.ac.uk.
authors: K Elizabeth
authors: KE
authors: Tanner
mesh_terms: D001672:Biocompatible Materials / Q000737:chemistry*; D018786:Bone Substitutes; D002384:Catalysis; D003470:Culture Media / Q000737:chemistry; D005898:Glass / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D008422:Materials Testing / Q000379:methods*; D008855:Microscopy, Electron, Scanning; D008970:Molecular Weight; D009985:Orthopedics; D010710:Phosphates / Q000737:chemistry*; D011091:Polyesters / Q000737:chemistry; D011108:Polymers / Q000737:chemistry*; D011312:Pressure; D012995:Solubility; D017550:Spectroscopy, Fourier Transform Infrared; D013059:Spectrum Analysis, Raman; D013314:Stress, Mechanical; D013696:Temperature; D013718:Tensile Strength; D023822:Tissue Engineering
chemical_list: D001672:Biocompatible Materials; D018786:Bone Substitutes; D003470:Culture Media; D010710:Phosphates; D011091:Polyesters; D011108:Polymers; C448991:corglaes