title: Bioinformatic Analysis of ChIP-seq Data on the Repetitive Ribosomal RNA Gene.
abstract: Ribosomal RNA genes are highly repetitive and therefore not annotated in genome assemblies. We did recently analyze the epigenetic and architectural regulation of murine ribosomal genes by the Transcription Termination Factor I and made use of genome-wide histone modification ChIP-seq data. This method paper describes how repetitive genomic regions can be integrated into custom genomic assemblies and be used with genome-wide profiling data.
authors: Biochemistry III, University of Regensburg, Universitätsstr. 31, 93053, Regensburg, Germany.
authors: Uwe
authors: U
authors: Schwartz
authors: Biochemistry III, University of Regensburg, Universitätsstr. 31, 93053, Regensburg, Germany. gernot.laengst@ur.de.
authors: Gernot
authors: G
authors: Längst
mesh_terms: D000818:Animals; D047369:Chromatin Immunoprecipitation; D019295:Computational Biology / Q000379:methods; D057890:Epigenomics; D020459:Genes, rRNA; D055106:Genome-Wide Association Study; D059014:High-Throughput Nucleotide Sequencing; D006657:Histones / Q000378:metabolism; D051379:Mice; D011786:Quality Control; D012091:Repetitive Sequences, Nucleic Acid; D012984:Software
chemical_list: D006657:Histones
keywords: Bioinformatics; ChIP-seq; Repetitive genomic elements; Ribosomal RNA gene