title: The pharmacoepigenetics of drug metabolism and transport in breast cancer: review of the literature and in silico analysis.
abstract: The focus of this manuscript is on DNA methylation and miRNA regulation of drug-metabolizing enzymes and drug transporters involved in the disposition of drugs commonly used in breast cancer. We start with a review of the available scant literature and follow with an in silico analysis of the CpG islands and miRNA binding sites of genes of interest. We make the case that there is room for further research to include more genes and miRNAs despite the extensive sharing of miRNA targets by candidate genes of interest. We also stress on the role of peripheral blood as a source of pharmacoepigenetic biomarkers, and point out the lack of toxicoepigenetic studies in breast cancer.
authors: Department of Anatomy, Cell Biology & Physiology, American University of Beirut Faculty of Medicine (AUBFM), Beirut, Lebanon.
authors: Rihab
authors: R
authors: Nasr
authors: Department of Pharmacology & Toxicology, American University of Beirut Faculty of Medicine (AUBFM), Beirut, Lebanon.
authors: Fatima
authors: F
authors: Sleiman
authors: Department of Pharmacology & Toxicology, American University of Beirut Faculty of Medicine (AUBFM), Beirut, Lebanon.
authors: Zeinab
authors: Z
authors: Awada
authors: Department of Pharmacology & Toxicology, American University of Beirut Faculty of Medicine (AUBFM), Beirut, Lebanon.
authors: Natalie K
authors: NK
authors: Zgheib
mesh_terms: D001692:Biological Transport; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000235:genetics / Q000378:metabolism; D018899:CpG Islands; D019175:DNA Methylation; D005260:Female; D006801:Humans; D035683:MicroRNAs / Q000032:analysis / Q000502:physiology; D004364:Pharmaceutical Preparations / Q000378:metabolism*; D010597:Pharmacogenetics
chemical_list: D035683:MicroRNAs; D004364:Pharmaceutical Preparations
keywords: breast cancer; drug transporters; drug-metabolizing enzymes; epigenetics; pharmacoepigenetics; pharmacogenetics; toxicoepigenetics