title: Presenting mitochondrial antigens: PINK1, Parkin and MDVs steal the show.
abstract: In a recent paper published in Cell, Matheoud et al. demonstrated that, in response to cellular stress, self-antigens can be extracted from mitochondria via mitochondrial-derived vesicles and presented at the cell surface to trigger an immune response; this pathway, termed mitochondrial antigen presentation (MitAP), is repressed by PINK1 and Parkin. These findings implicate autoimmune mechanisms in Parkinson's disease.
authors: McGill Parkinson Program, Neurodegenerative Diseases Group and Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, 3801 Rue University, Montréal, Quebec, H3A 2B4, Canada.
authors: Rosalind F
authors: RF
authors: Roberts
authors: McGill Parkinson Program, Neurodegenerative Diseases Group and Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, 3801 Rue University, Montréal, Quebec, H3A 2B4, Canada.
authors: Edward A
authors: EA
authors: Fon
mesh_terms: D017951:Antigen Presentation; D006801:Humans; D008928:Mitochondria; D010300:Parkinson Disease; D011494:Protein Kinases; D044767:Ubiquitin-Protein Ligases
chemical_list: D044767:Ubiquitin-Protein Ligases; D011494:Protein Kinases