title: Pharmacological profile of dexketoprofen in orofacial pain.
abstract: Non-steroidal anti-inflammatory drugs (NSAIDs) may act through others mechanisms, in addition to inhibition of prostaglandin synthesis. These includes cholinergic, NO, serotonergic and opioids pathways.
  
  
  
  The aim of this work was to evaluate the effect of systemic action of (S)-+-ketoprofen (dexketoprofen, DEX) on pain behaviors using the orofacial formalin test in mice and the potential involvement of cholinergic, NO, serotonergic and opioids pathways.
  
  
  
  The pretreatment of the mice with 1mg/kg ip of atropine or opoid antagonists: 1mg/kg, ip of NTX or 1mg/kg ip of NTI or 1mg/kg of NOR-BNI ip, did not produce significant change in the ED50values of the antinociception to orofacial test induced by DEX. The pretreatment of the mice with 0.5mg/kg ip tropisetron, increased in a significant fashion the values of ED50of DEX. When the mice were treated with 5mg/kg ip of L-NAME or 25mg/kg ip of aminoguanidine or 50mg/kg ip of 7-nitroindazole reversed the antinociception of DEX.
  
  
  
  The findings of this study demonstrate activation of NO and 5-HTpathways play important roles in the systemic antinociceptive effect of DEX in a murine model of inflammatory pain.
authors: Faculty of Medicine, School of Pharmacy, Andrés Bello University, Santiago, Chile; Pharmacology Program, ICBM, Faculty Santiago, Chile of Medicine, University of Chile, Santiago, Chile. Electronic address: hmiranda@med.uchile.cl.|Pharmacology Program, ICBM, Faculty Santiago, Chile of Medicine, University of Chile, Santiago, Chile; Faculty of Odontology, Finis Terrae University, Providencia, Chile.
authors: Hugo F
authors: HF
authors: Miranda
authors: Pharmacology Program, ICBM, Faculty Santiago, Chile of Medicine, University of Chile, Santiago, Chile; Faculty of Odontology, Finis Terrae University, Providencia, Chile.
authors: Fernando
authors: F
authors: Sierralta
authors: Pharmacology Program, ICBM, Faculty Santiago, Chile of Medicine, University of Chile, Santiago, Chile.
authors: Nicolás
authors: N
authors: Aranda
authors: Faculty of Medicine, School of Pharmacy, Andrés Bello University, Santiago, Chile; Cardiovascular Department, Clinic Hospital, University of Chile, Santiago, Chile.
authors: Viviana
authors: V
authors: Noriega
authors: Pharmacology Program, ICBM, Faculty Santiago, Chile of Medicine, University of Chile, Santiago, Chile; Faculty of Odontology, Finis Terrae University, Providencia, Chile.|Faculty of Medicine, School of Pharmacy, Andrés Bello University, Santiago, Chile; Cardiovascular Department, Clinic Hospital, University of Chile, Santiago, Chile.
authors: Juan Carlos
authors: JC
authors: Prieto
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D005157:Facial Pain / Q000188:drug therapy* / Q000473:pathology; D007660:Ketoprofen / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use; D008297:Male; D051379:Mice; D010147:Pain Measurement / Q000187:drug effects* / Q000379:methods; D014325:Tromethamine / Q000494:pharmacology / Q000627:therapeutic use*
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D014325:Tromethamine; D007660:Ketoprofen; C118296:dexketoprofen trometamol
keywords: 5-HT; ACh; Dexketoprofen; NO; Orofacial pain