title: DNA damage protective effect of honey-sweetened cashew apple nectar in Drosophila melanogaster.
abstract: Fruits and derivatives, such as juices, are complex mixtures of chemicals, some of which may have mutagenic and/or carcinogenic potential, while others may have antimutagenic and/or anticancer activities. The modulating effects of honey-sweetened cashew apple nectar (HSCAN), on somatic mutation and recombination induced by ethyl methanesulfonate (EMS) and mitomycin C (MMC) were evaluated with the wing spot test in Drosophila melanogaster using co- and post-treatment protocols. Additionally, the antimutagenic activity of two HSCAN components, cashew apple pulp and honey, in MMC-induced DNA damage was also investigated. HSCAN reduced the mutagenic activity of both EMS and MMC in the co-treatment protocol, but had a co-mutagenic effect when post-administered. Similar results were also observed with honey on MMC mutagenic activity. Cashew apple pulp was effective in exerting protective or enhancing effects on the MMC mutagenicity, depending on the administration protocol and concentration used. Overall, these results indicate that HSCAN, cashew apple and honey seem capable of modulating not only the events that precede the induced DNA damages, but also the Drosophila DNA repair processes involved in the correction of EMS and MMC-induced damages.
authors: Laboratório de Toxicidade Genética (TOXIGEN), Programa de Pós-Graduação em Biologia Celular e Molecular Aplicada à Saúde (PPGBIOSAÚDE), Universidade Luterana do Brasil (ULBRA), Canoas, RS, Brazil.|Instituto Federal de Educação, Ciência e Tecnologia do Piauí (IFPI), Teresina, PI, Brazil.
authors: Robson Alves da
authors: RA
authors: Silva
authors: Laboratório de Toxicidade Genética (TOXIGEN), Programa de Pós-Graduação em Biologia Celular e Molecular Aplicada à Saúde (PPGBIOSAÚDE), Universidade Luterana do Brasil (ULBRA), Canoas, RS, Brazil.
authors: Rafael Rodrigues
authors: RR
authors: Dihl
authors: Instituto Federal de Educação, Ciência e Tecnologia do Piauí (IFPI), Teresina, PI, Brazil.
authors: Lucas Pinheiro
authors: LP
authors: Dias
authors: Laboratório de Toxicidade Genética (TOXIGEN), Programa de Pós-Graduação em Biologia Celular e Molecular Aplicada à Saúde (PPGBIOSAÚDE), Universidade Luterana do Brasil (ULBRA), Canoas, RS, Brazil.
authors: Maiane Papke
authors: MP
authors: Costa
authors: Laboratório de Toxicidade Genética (TOXIGEN), Programa de Pós-Graduação em Biologia Celular e Molecular Aplicada à Saúde (PPGBIOSAÚDE), Universidade Luterana do Brasil (ULBRA), Canoas, RS, Brazil.
authors: Bianca Regina Ribas de
authors: BR
authors: Abreu
authors: Laboratório de Genética Toxicológica, Departamento de Bioquímica e Biologia Molecular, Instituto de Ciências Biológicas (ICB), Universidade Federal de Goiás (UFG), Goiânia, GO, Brazil.
authors: Kênya Silva
authors: KS
authors: Cunha
authors: Laboratório de Toxicidade Genética (TOXIGEN), Programa de Pós-Graduação em Biologia Celular e Molecular Aplicada à Saúde (PPGBIOSAÚDE), Universidade Luterana do Brasil (ULBRA), Canoas, RS, Brazil.
authors: Mauricio
authors: M
authors: Lehmann