title: Effect of Concentrated Growth Factor on Survival of Diced Cartilage Graft.
abstract: BACKGROUND
  Diced cartilage grafts are important in rhinoplasty for raising the dorsum and eliminating dorsal irregularities. The most common problems with the use of diced cartilage are wrapping and cartilage resorption.
  
  
  OBJECTIVE
  To histopathologically investigate and compare the viability of diced cartilage grafts wrapped with concentrated growth factor, fascia and fenestrated fascia, or blood glue.
  
  
  METHODS
  Cartilage grafts were harvested from the ears of 10 New Zealand White rabbits and diced into 0.5 to 1 mm3pieces. The grafts were divided into five groups for comparison: (1) bare diced cartilage; (2) diced cartilage wrapped with fascia; (3) diced cartilage wrapped with fenestrated fascia; (4) diced cartilage wrapped with concentrated growth factor (CGF); and (5) diced cartilage wrapped with blood glue. Each of the five grafts was autologously implanted into a subcutaneous pocket in the back of each rabbit. Three months later, the rabbits were sacrificed and the implants were harvested and examined histopathologically.
  
  
  RESULTS
  Nucleus loss, calcification, inflammation, and giant cell formation differed significantly between the CGF group and both fascia groups. Chondrocyte proliferation was the highest in the CGF group. Nucleus loss rates were similar between the fascia and fenestrated fascia groups.
  
  
  CONCLUSIONS
  Our findings suggest that CGF improves the viability of diced cartilage grafts, while fascia hampers it. Punching holes in the fascia does not improve diced cartilage graft viability and neither does blood glue wrapping.
authors: Drs Topkara, Özkan, and Özcan are Assistant Professors, Department of Plastic, Reconstructive, and Aesthetic Surgery, Pamukkale University Hospital, Denizli, Turkey. Dr Öksüz is a Specialist, Department of Plastic and Reconstructive and Aesthetic Surgery, Çekirge State Hospital, Bursa, Turkey. Dr Akbulut is a Professor, Department of Pathology, Pamukkale University Hospital, Denizli, Turkey.
authors: Adem
authors: A
authors: Topkara
authors: Drs Topkara, Özkan, and Özcan are Assistant Professors, Department of Plastic, Reconstructive, and Aesthetic Surgery, Pamukkale University Hospital, Denizli, Turkey. Dr Öksüz is a Specialist, Department of Plastic and Reconstructive and Aesthetic Surgery, Çekirge State Hospital, Bursa, Turkey. Dr Akbulut is a Professor, Department of Pathology, Pamukkale University Hospital, Denizli, Turkey.
authors: Adem
authors: A
authors: Özkan
authors: Drs Topkara, Özkan, and Özcan are Assistant Professors, Department of Plastic, Reconstructive, and Aesthetic Surgery, Pamukkale University Hospital, Denizli, Turkey. Dr Öksüz is a Specialist, Department of Plastic and Reconstructive and Aesthetic Surgery, Çekirge State Hospital, Bursa, Turkey. Dr Akbulut is a Professor, Department of Pathology, Pamukkale University Hospital, Denizli, Turkey.
authors: Ramazan Hakan
authors: RH
authors: Özcan
authors: Drs Topkara, Özkan, and Özcan are Assistant Professors, Department of Plastic, Reconstructive, and Aesthetic Surgery, Pamukkale University Hospital, Denizli, Turkey. Dr Öksüz is a Specialist, Department of Plastic and Reconstructive and Aesthetic Surgery, Çekirge State Hospital, Bursa, Turkey. Dr Akbulut is a Professor, Department of Pathology, Pamukkale University Hospital, Denizli, Turkey.
authors: Mustafa
authors: M
authors: Öksüz
authors: Drs Topkara, Özkan, and Özcan are Assistant Professors, Department of Plastic, Reconstructive, and Aesthetic Surgery, Pamukkale University Hospital, Denizli, Turkey. Dr Öksüz is a Specialist, Department of Plastic and Reconstructive and Aesthetic Surgery, Çekirge State Hospital, Bursa, Turkey. Dr Akbulut is a Professor, Department of Pathology, Pamukkale University Hospital, Denizli, Turkey.
authors: Metin
authors: M
authors: Akbulut
mesh_terms: D000818:Animals; D064131:Back Muscles / Q000637:transplantation; D002356:Cartilage / Q000187:drug effects* / Q000473:pathology / Q000637:transplantation*; D015718:Fibrin Tissue Adhesive; D006085:Graft Survival / Q000187:drug effects*; D036341:Intercellular Signaling Peptides and Proteins / Q000008:administration & dosage* / Q000097:blood; D008297:Male; D011817:Rabbits; D013997:Time Factors; D014022:Tissue Survival / Q000187:drug effects; D020858:Tissue and Organ Harvesting / Q000379:methods*; D014182:Transplantation, Autologous
chemical_list: D015718:Fibrin Tissue Adhesive; D036341:Intercellular Signaling Peptides and Proteins