title: Abnormalities in Chromosomes 1q and 13 Independently Correlate With Factors of Poor Prognosis in Multiple Myeloma.
abstract: BACKGROUND
  We comprehensively profiled cytogenetic abnormalities in multiple myeloma (MM) and analyzed the relationship between cytogenetic abnormalities of undetermined prognostic significance and established prognostic factors.
  
  
  METHODS
  The karyotype of 333 newly diagnosed MM cases was analyzed in association with established prognostic factors. Survival analysis was also performed.
  
  
  RESULTS
  MM with abnormal karyotypes (41.1%) exhibited high international scoring system (ISS) stage, frequent IgA type, elevated IgG or IgA levels, elevated calcium levels, elevated creatine (Cr) levels, elevated β2-microglobulin levels, and decreased Hb levels. Structural abnormalities in chromosomes 1q, 4, and 13 were independently associated with elevated levels of IgG or IgA, calcium, and Cr, respectively. Chromosome 13 abnormalities were associated with poor prognosis and decreased overall survival.
  
  
  CONCLUSIONS
  This is the first study to demonstrate that abnormalities in chromosomes 1q, 4, and 13 are associated with established factors for poor prognosis, irrespective of the presence of other concurrent chromosomal abnormalities. Chromosome 13 abnormalities have a prognostic impact on overall survival in association with elevated Cr levels. Frequent centromeric breakpoints appear to be related to MM pathogenesis.
authors: Department of Laboratory Medicine, Hallym University College of Medicine, Anyang, Korea.
authors: Miyoung
authors: M
authors: Kim
authors: Department of Occupational and Environmental Medicine, Hallym University College of Medicine, Anyang, Korea.
authors: Young Su
authors: YS
authors: Ju
authors: Department of Laboratory Medicine, Hallym University College of Medicine, Anyang, Korea.
authors: Eun Jin
authors: EJ
authors: Lee
authors: Department of Laboratory Medicine, Hallym University College of Medicine, Anyang, Korea.
authors: Hee Jung
authors: HJ
authors: Kang
authors: Department of Laboratory Medicine, Hallym University College of Medicine, Anyang, Korea.
authors: Han Sung
authors: HS
authors: Kim
authors: Department of Laboratory Medicine, Hallym University College of Medicine, Anyang, Korea.
authors: Hyoun Chan
authors: HC
authors: Cho
authors: Department of Internal Medicine, Hallym University College of Medicine, Anyang, Korea.
authors: Hyo Jung
authors: HJ
authors: Kim
authors: Department of Laboratory Medicine, Seoul National University College of Medicine, Seoul, Korea.
authors: Jung Ah
authors: JA
authors: Kim
authors: Department of Laboratory Medicine, Seoul National University College of Medicine, Seoul, Korea.|Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea.
authors: Dong Soon
authors: DS
authors: Lee
authors: Department of Laboratory Medicine, Hallym University College of Medicine, Anyang, Korea. lyoungk@hallym.or.kr.
authors: Young Kyung
authors: YK
authors: Lee
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002118:Calcium / Q000097:blood; D002869:Chromosome Aberrations; D002878:Chromosomes, Human, Pair 1; D002882:Chromosomes, Human, Pair 13; D002894:Chromosomes, Human, Pair 4; D003401:Creatine / Q000097:blood; D005260:Female; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D007070:Immunoglobulin A / Q000097:blood; D007074:Immunoglobulin G / Q000097:blood; D007621:Karyotyping; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000175:diagnosis* / Q000235:genetics / Q000401:mortality; D015999:Multivariate Analysis; D011379:Prognosis; D015996:Survival Rate; D055815:Young Adult
chemical_list: D006454:Hemoglobins; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D003401:Creatine; D002118:Calcium
keywords: Chromosome; Myeloma; Prognosis