title: [Arterial hypertension and prediabetes].
abstract: OBJECTIVE
  The aim of this study was to assess the factors related to new diabetes in hypertensive.
  
  
  METHODS
  This prospective follow-up study involved 2588 non-diabetic, hypertensive patients. The total follow-up was 15053 patient-years with a median of 3.4 years (interquartile interval 1.4-6.8).
  
  
  RESULTS
  During the follow-up 333 (13%) patients had new diabetes, with a conversion rate of 2.21 (95% confidence interval [CI], 1.98-2.46) 100/patients/year. In a Cox proportional hazard model including baseline characteristics and modifications during the follow up the three components of metabolic syndrome (excluding blood pressure and glucose values) HR 1.69 (95% CI, 1.36-2.09), family history of diabetes HR 1,49 (95% CI, 1,20-1,85) and baseline blood glucose ≥110 mg/dl HR 7.84 (95% CI, 5.99-10.29) were the most important factors related to new diabetes. Weight variation during the follow up, and statins, beta-bloquers or diuretic treatment did not increase the risk of new diabetes, blood pressure control at the end of study reduce the risk HR 0,74 (95% CI, 0.61-0.91).
  
  
  CONCLUSIONS
  In hypertensive non-diabetic patients in primary prevention the factors related to new diabetes can easily identified at the beginning of follow up. Being obese, with family history of diabetes, and glucose values ≥110 mg/dl dramatically increase the risk of developing new diabetes.
authors: Unidad de Hipertensión y Riesgo Vascular, Hospital de Sagunto, Sagunto, Valencia, España.
authors: Patricia
authors: P
authors: Boned Ombuena
authors: Unidad de Hipertensión y Riesgo Vascular, Hospital de Sagunto, Sagunto, Valencia, España; Área de Ciencias de la Salud, Universidad CEU Cardenal Herrera, Castellón, España.
authors: Enrique
authors: E
authors: Rodilla Sala
authors: Unidad de Hipertensión y Riesgo Vascular, Hospital de Sagunto, Sagunto, Valencia, España; Área de Ciencias de la Salud, Universidad CEU Cardenal Herrera, Castellón, España.
authors: José Antonio
authors: JA
authors: Costa Muñoz
authors: Unidad de Hipertensión y Riesgo Vascular, Hospital de Sagunto, Sagunto, Valencia, España; Facultad de Medicina, Universidad de Valencia, Valencia, España. Electronic address: pascual_jma@gva.es.
authors: José María
authors: JM
authors: Pascual Izuel
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003131:Combined Modality Therapy; D003924:Diabetes Mellitus, Type 2 / Q000175:diagnosis / Q000209:etiology* / Q000517:prevention & control*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006973:Hypertension / Q000150:complications* / Q000628:therapy; D008297:Male; D008875:Middle Aged; D011236:Prediabetic State / Q000175:diagnosis / Q000209:etiology* / Q000517:prevention & control*; D011322:Primary Prevention / Q000379:methods; D016016:Proportional Hazards Models; D011446:Prospective Studies; D012307:Risk Factors
keywords: Arterial hypertension; Estado prediabético; Hipertensión arterial; Metabolic syndrome; Prediabetic state; Síndrome metabólico