title: Association of Bioelectrical Impedance Analysis-Derived Phase Angle and Sarcopenia in Older Adults.
abstract: BACKGROUND
  Sarcopenia is an important problem for older adults, leading to morbidity and mortality; therefore, early detection with a precise method is essential. We aimed to investigate the role of bioelectrical impedance analysis-derived phase angle as a determinant of sarcopenia.
  
  
  METHODS
  A cross section of 263 community-dwelling and hospitalized older adults (>65 years) were assessed in terms of sarcopenia with bioelectrical indices and anthropometric measurements. Sarcopenic and nonsarcopenic groups were compared, and significant determinants of sarcopenia were further analyzed with multivariate logistic regression analysis.
  
  
  RESULTS
  Forty patients were diagnosed with sarcopenia. The following were significant correlates of sarcopenia: female sex, low weight/height, low body mass index, decreased muscle strength, low calf circumference, low skeletal muscle mass/index, high impedance at 50 kHz, a history of hypertension, worse nutrition status, and low phase angle. Diagnostic parameters with well-known association were omitted, and sex, height, weight, body mass index, creatinine, nutrition status, phase angle, impedance at 50 kHz, and hypertension category were included in regression analysis. The following were independent associated factors with sarcopenia: phase angle (odds ratio [OR]: 0.59, 95% confidence interval [95% CI]: 0.40-0.87, P = .008), body mass index (OR: 0.84, 95% CI: 0.77-0.93, P = .001) impedance at 50 kHz (OR: 1.010, 95% CI: 1.006-1.015, P < .001), and height (OR: 0.93, 95% CI: 0.88-0.97, P = .001). Receiver operating characteristic analysis revealed that the optimal phase angle cutoff value to detect sarcopenia was ≤4.55º.
  
  
  CONCLUSIONS
  Bioelectrical phase angle can be useful for diagnosis of sarcopenia.
authors: 1 Gazi University Faculty of Medicine, Department of Internal Medicine, Division of Geriatric Medicine, Ankara, Turkey.|2 Hacettepe University Faculty of Medicine, Department of Internal Medicine, Division of Geriatric Medicine, Ankara, Turkey.
authors: Mustafa Kemal
authors: MK
authors: Kilic
authors: 1 Gazi University Faculty of Medicine, Department of Internal Medicine, Division of Geriatric Medicine, Ankara, Turkey.|2 Hacettepe University Faculty of Medicine, Department of Internal Medicine, Division of Geriatric Medicine, Ankara, Turkey.
authors: Muhammet Cemal
authors: MC
authors: Kizilarslanoglu
authors: 1 Gazi University Faculty of Medicine, Department of Internal Medicine, Division of Geriatric Medicine, Ankara, Turkey.|2 Hacettepe University Faculty of Medicine, Department of Internal Medicine, Division of Geriatric Medicine, Ankara, Turkey.
authors: Gunes
authors: G
authors: Arik
authors: 3 Hacettepe University Faculty of Medicine, Department of Internal Medicine, Ankara, Turkey.
authors: Basak
authors: B
authors: Bolayir
authors: 1 Gazi University Faculty of Medicine, Department of Internal Medicine, Division of Geriatric Medicine, Ankara, Turkey.|2 Hacettepe University Faculty of Medicine, Department of Internal Medicine, Division of Geriatric Medicine, Ankara, Turkey.
authors: Ozgur
authors: O
authors: Kara
authors: 2 Hacettepe University Faculty of Medicine, Department of Internal Medicine, Division of Geriatric Medicine, Ankara, Turkey.
authors: Hacer
authors: H
authors: Dogan Varan
authors: 1 Gazi University Faculty of Medicine, Department of Internal Medicine, Division of Geriatric Medicine, Ankara, Turkey.
authors: Fatih
authors: F
authors: Sumer
authors: 2 Hacettepe University Faculty of Medicine, Department of Internal Medicine, Division of Geriatric Medicine, Ankara, Turkey.
authors: Mehmet Emin
authors: ME
authors: Kuyumcu
authors: 2 Hacettepe University Faculty of Medicine, Department of Internal Medicine, Division of Geriatric Medicine, Ankara, Turkey.
authors: Meltem
authors: M
authors: Halil
authors: 1 Gazi University Faculty of Medicine, Department of Internal Medicine, Division of Geriatric Medicine, Ankara, Turkey.
authors: Zekeriya
authors: Z
authors: Ulger
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000375:Aging; D015331:Cohort Studies; D015897:Comorbidity; D003430:Cross-Sectional Studies; D058620:Elder Nutritional Physiological Phenomena; D017097:Electric Impedance; D005260:Female; D015577:Geriatric Assessment; D006801:Humans; D008297:Male; D044342:Malnutrition / Q000175:diagnosis* / Q000453:epidemiology / Q000503:physiopathology; D015596:Nutrition Assessment; D009752:Nutritional Status; D010044:Outpatient Clinics, Hospital; D015995:Prevalence; D055948:Sarcopenia / Q000175:diagnosis* / Q000453:epidemiology / Q000503:physiopathology; D012680:Sensitivity and Specificity; D012720:Severity of Illness Index; D012737:Sex Factors; D062606:Tertiary Care Centers; D014421:Turkey / Q000453:epidemiology
keywords: aged; frail elderly; geriatric assessment; impedance; malnutrition; nutritional status; phase angle; sarcopenia