title: Renal Denervation in Patients with Resistant Hypertension-Assessment by 3T Renal 23Na-MRI: Preliminary Results.
abstract: OBJECTIVE
  Renal denervation (RDN) has been considered a promising therapy option for patients suffering from therapy-resistant hypertension. Besides, in blood-pressure regularization, the kidneys play a fundamental role in sodium ((23)Na) homeostasis. This study assesses the effect of RDN on renal (23)Na concentration using (23)Na magnetic resonance imaging (MRI).
  
  
  METHODS
  Two patients with therapy-resistant hypertension underwent RDN. (23)Na-MRI, (1)H-MRI, including diffusion weighted imaging (DWI), as well as endothelial dysfunction assessment, were performed 1 day prior, as well as 1, 30 and 90 days after RDN.
  
  
  RESULTS
  The renal corticomedullary (23)Na gradient did not change after RDN for all time points. Additionally, functional imaging and retinal vessel parameters were not influenced by RDN. Results regarding blood pressure changes and arterial stiffness, as well as patients' clinical outcome, were heterogeneous.
  
  
  CONCLUSIONS
  RDN does not seem to alter renal (23)Na concentration gradients, as measured by MRI.
authors: Department of Clinical Radiology and Nuclear Medicine, University Medical Center Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany johannes.budjan@umm.de.
authors: Johannes
authors: J
authors: Budjan
authors: Fifth Department of Internal Medicine (Nephrology/Endocrinology/Rheumatology), University Medical Center Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
authors: Urs
authors: U
authors: Benck
authors: Fifth Department of Internal Medicine (Nephrology/Endocrinology/Rheumatology), University Medical Center Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
authors: Alexander
authors: A
authors: Lammert
authors: Department of Clinical Radiology and Nuclear Medicine, University Medical Center Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
authors: Melissa M
authors: MM
authors: Ong
authors: Fifth Department of Internal Medicine (Nephrology/Endocrinology/Rheumatology), University Medical Center Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
authors: Miryana
authors: M
authors: Mircheva
authors: Department of Clinical Radiology and Nuclear Medicine, University Medical Center Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
authors: Steffen
authors: S
authors: Diehl
authors: Computer Assisted Clinical Medicine, University Medical Center Mannheim, Mannheim, Germany MR-Imaging and Spectroscopy, Faculty 01 (Physics/Electrical Engineering), University of Bremen, Bremen, Germany.
authors: Simon
authors: S
authors: Konstandin
authors: Computer Assisted Clinical Medicine, University Medical Center Mannheim, Mannheim, Germany.
authors: Lothar R
authors: LR
authors: Schad
authors: Fifth Department of Internal Medicine (Nephrology/Endocrinology/Rheumatology), University Medical Center Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
authors: Bernhard K
authors: BK
authors: Krämer
authors: Department of Clinical Radiology and Nuclear Medicine, University Medical Center Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
authors: Stefan O
authors: SO
authors: Schoenberg
authors: Department of Clinical Radiology and Nuclear Medicine, University Medical Center Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany Department of Radiology, University Hospital of Cologne, Cologne, Germany.
authors: Stefan
authors: S
authors: Haneder
mesh_terms: D000328:Adult; D000368:Aged; D001794:Blood Pressure; D003329:Coronary Vasospasm / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery*; D003714:Denervation / Q000009:adverse effects / Q000379:methods*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery*; D007668:Kidney / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery*; D008279:Magnetic Resonance Imaging; D012964:Sodium / Q000378:metabolism; D012979:Sodium Radioisotopes / Q000008:administration & dosage; D016896:Treatment Outcome; D059289:Vascular Stiffness / Q000502:physiology
chemical_list: D012979:Sodium Radioisotopes; D012964:Sodium
keywords: Renal denervation; hypertension; magnetic resonance imaging; sodium imaging