title: Decreased expression of stomatin predicts poor prognosis in HER2-positive breast cancer.
abstract: Human epidermal growth factor receptor-2 (HER2) is a transmembrane tyrosine kinase receptor that is overexpressed in 25 to 30 % of human breast cancers and is preferentially localized in lipid rafts. Stomatin is a membrane protein that is absent from the erythrocyte plasma membrane in patients with congenital stomatocytosis and is the major component of the lipid raft.
  
  
  
  In a total of 68 clinical cases of HER2-positive breast cancer, the absence of stomatin expression was associated with a decreased 5-year survival (65 % vs. 93 %, p = 0.005) by survival analysis. For stage I-III HER2-positive breast cancer, the absence of stomatin expression was associated with a decreased 5-year disease-free survival (57 % vs. 81 %, p = 0.016) and was an independent prognostic factor by multivariate analysis. Negative stomatin expression predicts distant metastases in a hazard ratio of 4.0 (95 % confidence interval from 1.3 to 12.5).
  
  
  
  These results may suggest that stomatin is a new prognostic indicator for HER2-positive breast cancer.
authors: Institute of Microbiology and Immunology, National Yang-Ming University, 155, Sec.2, Li-Nong St, Taipei, 11221, Taiwan, Republic of China.|Department of Surgery, National Yang-Ming University Hospital, Yilan County, Taiwan, Republic of China.
authors: Chin-Yau
authors: CY
authors: Chen
authors: Institute of Microbiology and Immunology, National Yang-Ming University, 155, Sec.2, Li-Nong St, Taipei, 11221, Taiwan, Republic of China.|Department of Education and Research, Taipei City Hospital, Taipei, Taiwan, Republic of China.
authors: Chih-Yung
authors: CY
authors: Yang
authors: Department of Pathology, National Yang-Ming University Hospital, Yilan County, Taiwan, Republic of China.
authors: Yen-Chung
authors: YC
authors: Chen
authors: Department of Pathology, Lotung Poh-Ai Hospital, Yilan County, Taiwan, Republic of China.
authors: Chia-Wen
authors: CW
authors: Shih
authors: Department of Surgery, National Yang-Ming University Hospital, Yilan County, Taiwan, Republic of China.
authors: Su-Shun
authors: SS
authors: Lo
authors: Institute of Microbiology and Immunology, National Yang-Ming University, 155, Sec.2, Li-Nong St, Taipei, 11221, Taiwan, Republic of China. linch@ym.edu.tw.
authors: Chi-Hung
authors: CH
authors: Lin
mesh_terms: D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis*; D001943:Breast Neoplasms / Q000378:metabolism / Q000401:mortality / Q000473:pathology*; D018270:Carcinoma, Ductal, Breast / Q000378:metabolism / Q000401:mortality / Q000473:pathology*; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D053208:Kaplan-Meier Estimate; D008565:Membrane Proteins / Q000096:biosynthesis*; D008875:Middle Aged; D011379:Prognosis; D016016:Proportional Hazards Models; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000096:biosynthesis
chemical_list: D014408:Biomarkers, Tumor; D008565:Membrane Proteins; D018719:Erb-b2 Receptor Tyrosine Kinases; C036860:STOM protein, human; C508053:ERBB2 protein, human
keywords: Breast cancer; HER2; Stomatin; Tumor biomarkers