title: Genetic variants of SOX9 contribute to susceptibility of gliomas among Chinese population.
abstract: Gliomas make up about 80% of all malignant brain tumors, and cause serious public health problem. Genetic factors and environmental factors jointly caused the development of gliomas, and understanding of the genetic basis is a key component of preventive oncology. However, most genetic factors underlying carcinogenesis of gliomas remain largely unclear. In current study, we systematically evaluated whether genetic variants of SOX9 gene, a transcription factor that plays a central role in the development and differentiation of tumors, contribute to susceptibility of gliomas among Chinese population using a two-stage, case-control study. Results showed that SOX9 rs1042667 was significant associated with increased gliomas risk after adjusted by age, gender, family history of cancer, smoking status and alcohol status (Allele C vs A: OR=1.25; 95% CI=1.11-1.40; P=1.2×10-4). Compared with the carriers of genotype AA, both those of genotype AC (OR=1.37; 95% CI=1.13-1.66) and CC (OR=1.53; 95% CI=1.22-1.91) had significantly increased gliomas risk. This should be the first genetic association study which aims to evaluated the association between genetic variants of SOX9 and susceptibility of gliomas. Additional functional and association studies with different ethnic groups included are needed to further confirm our results.
authors: Department of Neurosurgery, Tangdu Hospital, Fourth Military Medical University, Xi’an 710038, China.
authors: Liang
authors: L
authors: Wang
authors: Department of Neurosurgery, Tangdu Hospital, Fourth Military Medical University, Xi’an 710038, China.
authors: Gang
authors: G
authors: Li
authors: Department of Experimental Surgery, Tangdu Hospital, Fourth Military Medical University, Xi’an 710038, China.
authors: Nan
authors: N
authors: Liu
authors: Department of Experimental Surgery, Tangdu Hospital, Fourth Military Medical University, Xi’an 710038, China.
authors: Zhen
authors: Z
authors: Wang
authors: Department of Experimental Surgery, Tangdu Hospital, Fourth Military Medical University, Xi’an 710038, China.
authors: Xiaoshan
authors: X
authors: Xu
authors: Department of Experimental Surgery, Tangdu Hospital, Fourth Military Medical University, Xi’an 710038, China.
authors: Jing
authors: J
authors: Qi
authors: Department of Experimental Surgery, Tangdu Hospital, Fourth Military Medical University, Xi’an 710038, China.
authors: Dongni
authors: D
authors: Ren
authors: Department of Experimental Surgery, Tangdu Hospital, Fourth Military Medical University, Xi’an 710038, China.
authors: Pengxing
authors: P
authors: Zhang
authors: Department of Administrative, Tangdu Hospital, Fourth Military Medical University, Xi’an 710038, China.
authors: Yongsheng
authors: Y
authors: Zhang
authors: Department of Experimental Surgery, Tangdu Hospital, Fourth Military Medical University, Xi’an 710038, China.
authors: Yanyang
authors: Y
authors: Tu
mesh_terms: D044466:Asian People / Q000235:genetics*; D014408:Biomarkers, Tumor / Q000235:genetics*; D001932:Brain Neoplasms / Q000453:epidemiology / Q000235:genetics* / Q000473:pathology; D016022:Case-Control Studies; D002681:China / Q000453:epidemiology; D005260:Female; D005500:Follow-Up Studies; D059647:Gene-Environment Interaction; D020022:Genetic Predisposition to Disease; D005910:Glioma / Q000453:epidemiology / Q000235:genetics* / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D011379:Prognosis; D012307:Risk Factors; D055758:SOX9 Transcription Factor / Q000235:genetics*
chemical_list: D014408:Biomarkers, Tumor; D055758:SOX9 Transcription Factor; C527932:SOX9 protein, human
keywords: SOX9; genetic susceptibility; gliomas; polymorphism