title: Pupil Tracking for Real-Time Motion Corrected Anterior Segment Optical Coherence Tomography.
abstract: Volumetric acquisition with anterior segment optical coherence tomography (ASOCT) is necessary to obtain accurate representations of the tissue structure and to account for asymmetries of the anterior eye anatomy. Additionally, recent interest in imaging of anterior segment vasculature and aqueous humor flow resulted in application of OCT angiography techniques to generate en face and 3D micro-vasculature maps of the anterior segment. Unfortunately, ASOCT structural and vasculature imaging systems do not capture volumes instantaneously and are subject to motion artifacts due to involuntary eye motion that may hinder their accuracy and repeatability. Several groups have demonstrated real-time tracking for motion-compensated in vivo OCT retinal imaging, but these techniques are not applicable in the anterior segment. In this work, we demonstrate a simple and low-cost pupil tracking system integrated into a custom swept-source OCT system for real-time motion-compensated anterior segment volumetric imaging. Pupil oculography hardware coaxial with the swept-source OCT system enabled fast detection and tracking of the pupil centroid. The pupil tracking ASOCT system with a field of view of 15 x 15 mm achieved diffraction-limited imaging over a lateral tracking range of +/- 2.5 mm and was able to correct eye motion at up to 22 Hz. Pupil tracking ASOCT offers a novel real-time motion compensation approach that may facilitate accurate and reproducible anterior segment imaging.
authors: Department of Biomedical Engineering, Duke University, Durham, North Carolina, United States of America.
authors: Oscar M
authors: OM
authors: Carrasco-Zevallos
authors: Department of Biomedical Engineering, Duke University, Durham, North Carolina, United States of America.
authors: Derek
authors: D
authors: Nankivil
authors: Department of Biomedical Engineering, Duke University, Durham, North Carolina, United States of America.
authors: Christian
authors: C
authors: Viehland
authors: Department of Biomedical Engineering, Duke University, Durham, North Carolina, United States of America.
authors: Brenton
authors: B
authors: Keller
authors: Department of Biomedical Engineering, Duke University, Durham, North Carolina, United States of America.|Department of Ophthalmology, Duke University Medical Center, Durham, North Carolina, United States of America.
authors: Joseph A
authors: JA
authors: Izatt
mesh_terms: D000869:Anterior Eye Segment / Q000033:anatomy & histology*; D016477:Artifacts; D006801:Humans; D021621:Imaging, Three-Dimensional; D009038:Motion; D011680:Pupil / Q000502:physiology*; D041623:Tomography, Optical Coherence / Q000379:methods*