title: Gold-Catalyzed β-Regioselective Formal [3 + 2] Cycloaddition of Ynamides with Pyrido[1,2-b]indazoles: Reaction Development and Mechanistic Insights.
abstract: Here, we report an unprecedented gold(I)-induced β-site regioselective formal [3 + 2] cycloaddition of ynamides with pyrido[1,2-b]indazoles, giving 3-amido-7-(pyrid-2'-yl)indoles in good to excellent yields. A complex of gold(I) catalyst with ynamide was isolated and characterized by X-ray diffraction analysis for the first time. Mechanistic investigations suggest the reaction pathway involves a gold-stabilized carbocation intermediate, which in turn participated in sequential C-H bond functionalization of the ortho-position of the phenyl ring.
authors: Key Laboratory of Coal to Ethylene Glycol and Its Related Technology, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences , Yangqiao West Road 155#, Fuzhou, Fujian 350002, China.
authors: Yinghua
authors: Y
authors: Yu
authors: Key Laboratory of Coal to Ethylene Glycol and Its Related Technology, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences , Yangqiao West Road 155#, Fuzhou, Fujian 350002, China.
authors: Gui
authors: G
authors: Chen
authors: Key Laboratory of Coal to Ethylene Glycol and Its Related Technology, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences , Yangqiao West Road 155#, Fuzhou, Fujian 350002, China.
authors: Lei
authors: L
authors: Zhu
authors: Key Laboratory of Coal to Ethylene Glycol and Its Related Technology, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences , Yangqiao West Road 155#, Fuzhou, Fujian 350002, China.|College of Chemistry, Fuzhou University , Fuzhou, Fujian 350108, China.
authors: Yun
authors: Y
authors: Liao
authors: Key Laboratory of Coal to Ethylene Glycol and Its Related Technology, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences , Yangqiao West Road 155#, Fuzhou, Fujian 350002, China.|College of Chemistry, Fuzhou University , Fuzhou, Fujian 350108, China.
authors: Yufeng
authors: Y
authors: Wu
authors: Key Laboratory of Coal to Ethylene Glycol and Its Related Technology, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences , Yangqiao West Road 155#, Fuzhou, Fujian 350002, China.
authors: Xueliang
authors: X
authors: Huang