title: The role of cord blood BDNF in infant cognitive impairment induced by low-level prenatal manganese exposure: LW birth cohort, China.
abstract: This study aimed to examine the potential association between low-level prenatal manganese (Mn) exposure and 1-year-old children's neurodevelopment quotient (DQ) by using the Gesell Developmental Inventory (GDI) (motor, adaptive, language, and social domains) and explored the role of brain-derived neurotrophic factor (BDNF) in Mn-induced cognitive impairments. A total of 377 mothers were recruited from a prospective birth cohort in rural northern China. Cord serum concentrations of Mn and BDNF were measured and children's DQ was evaluated. The median serum Mn concentration was 3.4 μg/L. After adjusting for confounding factors, Mn level was significantly associated with gross motor scores (β = -6.0, 95% CI: -11.8 to -0.2, p < 0.05) and personal-social scores (β = -4.2, 95% CI: -8.4 to 0.1, p < 0.05). BDNF level was positively correlated with personal-social score (β = 0.7, 95% CI: 0-1.4, p < 0.05). A significant correlation was found between Mn and BDNF (r = -0.13, 95% CI: -0.23 to -0.03, p < 0.01). Furthermore, the interaction between cord serum Mn and BDNF was significant (p < 0.001). In conclusion, elevated low-level prenatal Mn exposure impaired infant's neurodevelopment, and BDNF plays an important role in cognitive impairment, especially in the personal-social ability.
authors: MOE-Shanghai Key Lab of Children's Environmental Health, Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, People's Republic of China.
authors: Xiaodan
authors: X
authors: Yu
authors: Department of Environmental Health, School of Public Health, Shanghai Jiaotong University School of Medicine, Shanghai, People's Republic of China.
authors: Limei
authors: L
authors: Chen
authors: Department of Environmental Health, School of Public Health, Shanghai Jiaotong University School of Medicine, Shanghai, People's Republic of China.
authors: Caifeng
authors: C
authors: Wang
authors: MOE-Shanghai Key Lab of Children's Environmental Health, Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, People's Republic of China.
authors: Xin
authors: X
authors: Yang
authors: Department of Environmental Health, School of Public Health, Shanghai Jiaotong University School of Medicine, Shanghai, People's Republic of China.
authors: Yu
authors: Y
authors: Gao
authors: MOE-Shanghai Key Lab of Children's Environmental Health, Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, People's Republic of China; Department of Environmental Health, School of Public Health, Shanghai Jiaotong University School of Medicine, Shanghai, People's Republic of China. Electronic address: tianmiejp@sjtu.edu.cn.
authors: Ying
authors: Y
authors: Tian
mesh_terms: D000328:Adult; D019208:Brain-Derived Neurotrophic Factor / Q000097:blood*; D002681:China; D003072:Cognition Disorders / Q000097:blood; D060825:Cognitive Dysfunction / Q000097:blood; D005260:Female; D005312:Fetal Blood / Q000737:chemistry*; D006801:Humans; D007223:Infant; D008297:Male; D008345:Manganese / Q000097:blood*; D008423:Maternal Age; D018811:Maternal Exposure / Q000009:adverse effects*; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000097:blood*; D011446:Prospective Studies; D012307:Risk Factors
chemical_list: D019208:Brain-Derived Neurotrophic Factor; D008345:Manganese; C579455:BDNF protein, human
keywords: BDNF; Children's neurobehavioral development; Epidemiology; Mn; Prenatal exposure