title: Prostate Cancer Related JAZF1 Gene is Associated with Schizophrenia.
abstract: BACKGROUND
  Epidemiological studies have shown that there is a reduced risk of prostate cancer among persons diagnosed with schizophrenia (SCZ). However, the mechanism of such relationship is not clear. The reduced incidence of cancer observed in SCZ patients may be related to differences in genetic background. Recently, the JAZF1 gene is found to be associated with prostate cancer and type 2 diabetes. However, no study has focused on the association of JAZF1 with the risk of SCZ.
  
  
  METHODS
  We examined genetic associations of 118 single-nucleotide polymorphisms (SNPs) within the JAZF1 gene with SCZ using one European American (EA) sample of 1,149 cases and 1,347 controls. Logistic regression analysis of SCZ as a binary trait was performed using PLINK software.
  
  
  RESULTS
  The most significant association with SCZ was observed with rs10258132 (p = 0.0011); while the next best signal was rs17156259 (p = 0.0031). The third best associated SNP was rs7791865 (p = 0.00889). In addition, haplotype analyses revealed that the A-C haplotype from rs10244184 and rs10258132 was associated with SCZ (p = 0.00093); and the G-G haplotype from rs17156238 and rs17156259 was associated with SCZ (p = 0.00455).
  
  
  CONCLUSIONS
  These findings provide evidence of several genetic variants in JAZF1 gene influencing the risk of SCZ and will serve as a resource for replication in other populations.
authors: Department of Biostatistics and Epidemiology, College of Public Health, East Tennessee State University, Johnson City, TN, USA.
authors: Ke-Sheng
authors: KS
authors: Wang
authors: Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.
authors: Lingjun
authors: L
authors: Zuo
authors: Department of Biostatistics and Epidemiology, College of Public Health, East Tennessee State University, Johnson City, TN, USA.
authors: Daniel
authors: D
authors: Owusu
authors: Department of Public Health Sciences, Miller School of Medicine, University of Miami, Miami, FL, USA.
authors: Yue
authors: Y
authors: Pan
authors: Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA; Biological Psychiatry Research Center, Beijing Huilongguan Hospital, Beijing, China.
authors: Xingguang
authors: X
authors: Luo
keywords: JAZF1; Pleiotropy; Prostate cancer; Schizophrenia; Single nucleotide polymorphism