title: Mesenchymal stem cells in tissue repairing and regeneration: Progress and future.
abstract: The presence of mesenchymal progenitor cells within bone marrow has been known since the late nineteenth century. To date, mesenchymal stem cells (MSCs) have been isolated from several different connective tissues, such as adipose tissue, muscle, placenta, umbilical cord matrix, blood, liver, and dental pulp. Bone marrow, however, is still one of the major sources of MSCs for preclinical and clinical research. MSCs were first evaluated for regenerative applications and have since been shown to directly influence the immune system and to promote neovascularization of ischemic tissues. These observations have prompted a new era of MSC transplantation as a treatment for various diseases. In this review, we summarize the important studies that have investigated the use of MSCs as a therapeutic agent for regenerative medicine, immune disorders, cancer, and gene therapy. Furthermore, we discuss the mechanisms involved in MSC-based therapies and clinical-grade MSC manufacturing.
authors: Stem Cell and Regenerative Medicine Lab, Beijing Institute of Transfusion Medicine, 27, Tai Ping Road, Beijing, 100850 China.
authors: Jiafei
authors: J
authors: Xi
authors: Stem Cell and Regenerative Medicine Lab, Beijing Institute of Transfusion Medicine, 27, Tai Ping Road, Beijing, 100850 China.
authors: Xinlong
authors: X
authors: Yan
authors: Stem Cell and Regenerative Medicine Lab, Beijing Institute of Transfusion Medicine, 27, Tai Ping Road, Beijing, 100850 China.
authors: Junnian
authors: J
authors: Zhou
authors: Stem Cell and Regenerative Medicine Lab, Beijing Institute of Transfusion Medicine, 27, Tai Ping Road, Beijing, 100850 China.
authors: Wen
authors: W
authors: Yue
authors: Stem Cell and Regenerative Medicine Lab, Beijing Institute of Transfusion Medicine, 27, Tai Ping Road, Beijing, 100850 China.
authors: Xuetao
authors: X
authors: Pei
keywords: Mesenchymal stem cells; anticancer; gene therapy; immune disorder; regenerative medicine