title: Investigation of membrane fatty acid profiles in erythrocytes of patients with stable coronary artery disease.
abstract: The association between the erythrocyte membrane fatty acids and the severity of coronary stenosis has not been studied in patients with stable coronary artery disease (CAD).
  
  
  
  We sought to investigate whether the fatty acid profile of erythrocyte membranes is significantly different in patients with stable CAD compared with patients with nonsignificant coronary stenosis and evaluate a possible relationship between fatty acid profile and the severity of coronary stenosis.
  
  
  
  The population included 144 patients, undergoing clinically indicated coronary angiography. The severity of coronary stenosis was scored after coronary angiography, and patients were divided into 2 groups; the S-stenosis group (CAD patients, n = 82) had a significant stenosis indicated by coronary angiography and the second group, S-stenosis (n = 62), had nonsignificant coronary stenosis.
  
  
  
  The erythrocyte membranes linoleic acid (LA) levels were lower (P < .001) and the arachidonic acid (AA)-to-LA ratio, a marker of desaturase activity, were higher (P < .001) in CAD patients compared with S-stenosis patients. The CAD scores were correlated negatively with the membrane LA levels (r = -0.338; P < .001) and positively with the AA-to-LA ratio (r = 0.306; P < .001).
  
  
  
  This study shows that LA levels of the erythrocyte membrane and AA-to-LA ratio are correlated with the severity of CAD.
authors: Department of Clinical Biochemistry, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran.
authors: Gholamreza
authors: G
authors: Namazi
authors: Isfahan Cardiovascular Research Center, Isfahan Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran.
authors: Parastoo
authors: P
authors: Asa
authors: Department of Clinical Biochemistry, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran.
authors: Ahmad
authors: A
authors: Movahedian
authors: Isfahan Cardiovascular Research Center, Isfahan Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran.
authors: Nizal
authors: N
authors: Sarrafzadegan
authors: Cardiac Rehabilitation Research Center, Isfahan Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran.
authors: Masoumeh
authors: M
authors: Sadeghi
authors: Department of Clinical Biochemistry, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran; Isfahan Cardiovascular Research Center, Isfahan Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran. Electronic address: Pourfarzam@pharm.mui.ac.ir.
authors: Morteza
authors: M
authors: Pourfarzam
mesh_terms: D003324:Coronary Artery Disease / Q000097:blood* / Q000378:metabolism*; D004910:Erythrocyte Membrane / Q000378:metabolism*; D005227:Fatty Acids / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012307:Risk Factors
chemical_list: D005227:Fatty Acids
keywords: Coronary artery disease; Erythrocyte membrane; Fatty acid profile; Gas Chromatography-Mass Spectrometry