title: Gd-Hybridized Plasmonic Au-Nanocomposites Enhanced Tumor-Interior Drug Permeability in Multimodal Imaging-Guided Therapy.
abstract: An original gadolinium-hybridized plasmonic gold nanocomposite is fabricated to provide an insightful and attractive strategy to overcome both the physiological and pathological barriers of tumor, and increase the transportation and permeability of imaging agents and drugs in tumor interior for achieving high-sensitive multimodal imaging and simultaneously improving the therapeutic efficacy of cancer.
authors: CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety and CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology (NCNST), No.11, 1st North Street, Zhongguancun, Beijing, 100190, China.
authors: Jing
authors: J
authors: Wang
authors: CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety and CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology (NCNST), No.11, 1st North Street, Zhongguancun, Beijing, 100190, China.
authors: Jing
authors: J
authors: Liu
authors: CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety and CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology (NCNST), No.11, 1st North Street, Zhongguancun, Beijing, 100190, China.
authors: Ying
authors: Y
authors: Liu
authors: CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety and CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology (NCNST), No.11, 1st North Street, Zhongguancun, Beijing, 100190, China.
authors: Liming
authors: L
authors: Wang
authors: CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety and CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology (NCNST), No.11, 1st North Street, Zhongguancun, Beijing, 100190, China.
authors: Mingjing
authors: M
authors: Cao
authors: CAS Key Laboratory of Standardization and Measurement for Nanotechnology, NCNST, No.11, 1st North Street, Zhongguancun, Beijing, 100190, China.
authors: Yinglu
authors: Y
authors: Ji
authors: CAS Key Laboratory of Standardization and Measurement for Nanotechnology, NCNST, No.11, 1st North Street, Zhongguancun, Beijing, 100190, China.
authors: Xiaochun
authors: X
authors: Wu
authors: CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety and CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology (NCNST), No.11, 1st North Street, Zhongguancun, Beijing, 100190, China.
authors: Yingying
authors: Y
authors: Xu
authors: CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety and CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology (NCNST), No.11, 1st North Street, Zhongguancun, Beijing, 100190, China.
authors: Bing
authors: B
authors: Bai
authors: CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety and CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology (NCNST), No.11, 1st North Street, Zhongguancun, Beijing, 100190, China.
authors: Qing
authors: Q
authors: Miao
authors: CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety and CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology (NCNST), No.11, 1st North Street, Zhongguancun, Beijing, 100190, China.
authors: Chunying
authors: C
authors: Chen
authors: CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety and CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology (NCNST), No.11, 1st North Street, Zhongguancun, Beijing, 100190, China. zhaoyl@nanoctr.cn, zhaoyuliang@ihep.ac.cn.
authors: Yuliang
authors: Y
authors: Zhao
mesh_terms: D005682:Gadolinium; D006046:Gold; D064847:Multimodal Imaging; D053761:Nanocomposites; D009369:Neoplasms; D010539:Permeability
chemical_list: D006046:Gold; D005682:Gadolinium
keywords: drug delivery; enhanced pathological permeability; gold nanocomposites; multimodal imaging; tumor penetration