title: Clinical Significance of Preoperative Neutrophil - to - Lymphocyte Ratio in Renal Cell Carcinoma.
abstract: BACKGROUND
  We investigated the prognostic significance of the neutrophil-to-lymphocyte ratio on tumor stage and Fuhrman nuclear grade in renal cell carcinoma.
  
  
  METHODS
  The records of 432 patients with RCC who underwent radical or partial nephrectomy between 2005 and 2014 were retrospectively reviewed. Patients were classified as group lower tumor stage(T1 + T2) and higher(T3 + T4). As like tumor stage, Fuhrman nuclear grade were classified lower (G1+G2) and higher(G3+G4) too. The best NLR cut off value was 3.01.Two sample t-test or Mann-Whitney U-test used for the continuous variables and a chi-square test or Fisher's exact test used for the categorical variables.
  
  
  RESULTS
  Among the 432 total patients analyzed in our study, there were 275 males (63.7%) and 157 females (36.3%). Mean laboratory values were CRP 2.73 ± 1.93 mg/ dL (normal less than 0.3), neutrophil count 4,23 ± 1.46/μL, lymphocyte count 1,61 ± 0,61/μL and NLR 2.64 ± 1.24. According to our data, statistically pretreatment NLR significantly correlated with CRP (p<0.0001). And tumor patologic stage (p=0.08), tumor histologic grade (p<0.001) was significantly associated with NLR.
  
  
  CONCLUSIONS
  We compared the relationship of preoperative NLR and NC parameters with RCC tumor stage and grade. And NLR were found to have statistically significant higher T stage and grade at RCC. Further studies with more patients are needed to confirm our study.
authors: Department of Urology, Okmeydani Training and Research Hospital, Istanbul, Turkey.
authors: Alper
authors: A
authors: Otunctemur
authors: Department of Urology, Okmeydani Training and Research Hospital, Istanbul, Turkey.
authors: Murat
authors: M
authors: Dursun
authors: Department of Urology, Okmeydani Training and Research Hospital, Istanbul, Turkey.
authors: Huseyin
authors: H
authors: Besiroglu
authors: Department of Urology, Ataturk Training and Research Hospital, Izmir, Turkey.
authors: Kutan
authors: K
authors: Ozer
authors: Department of Urology, Ataturk Training and Research Hospital, Izmir, Turkey.
authors: Ozan
authors: O
authors: Horsanali
authors: Department of Urology, Okmeydani Training and Research Hospital, Istanbul, Turkey.
authors: Emin
authors: E
authors: Ozbek
mesh_terms: D000368:Aged; D002292:Carcinoma, Renal Cell / Q000097:blood / Q000473:pathology* / Q000601:surgery; D005260:Female; D006801:Humans; D007680:Kidney Neoplasms / Q000097:blood / Q000473:pathology* / Q000601:surgery; D018655:Lymphocyte Count; D008214:Lymphocytes; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D009504:Neutrophils; D011300:Preoperative Care; D011379:Prognosis; D012189:Retrospective Studies; D012307:Risk Factors
keywords: Carcinoma, Renal Cell; Epithelium; Neutrophils