title: The development of an online database for interventions tested in transgenic mouse models of Alzheimer's disease.
abstract: Despite many efforts by the research community, Alzheimer's disease (AD) is still an incurable neurodegenerative condition that affects an estimated 44 million individuals worldwide and this figure is expected to increase to 135 million by the year 2050. As the research community currently reflects on previous endeavours, it is essential that we maximize the use of existing knowledge to inform future trials in the field. This article describes the development of a systematically identified data set relating to over 300 interventions tested in over 10,000 animals. The data set includes cohort-level information for six structural outcomes and six behavioural assessments. We encourage others to use this dataset to inform the design of future animal experiments modelling AD and to promote effective translation to human health.
authors: Department of Clinical Neurosciences University of Edinburgh Edinburgh UK.
authors: K J
authors: KJ
authors: Egan
authors: Department of Clinical Neurosciences University of Edinburgh Edinburgh UK.
authors: H M
authors: HM
authors: Vesterinen
authors: Stroke Division Florey Institute of Neuroscience and Mental Health Melbourne Australia.
authors: S K
authors: SK
authors: McCann
authors: Department of Clinical Neurosciences University of Edinburgh Edinburgh UK; Stroke Division Florey Institute of Neuroscience and Mental Health Melbourne Australia.
authors: E S
authors: ES
authors: Sena
authors: Department of Clinical Neurosciences University of Edinburgh Edinburgh UK.
authors: M R
authors: MR
authors: MacLeod
keywords: Alzheimer's disease; data; transgenic mouse models; translational failure