title: Predictors of Impaired Postpartum Renal Function in Women after Preeclampsia: Results of a Prospective Single Center Study.
abstract: Objective. The purpose of this prospective study was to investigate the predictive value of single prepartum findings combined with serum biomarkers sFlt-1 (soluble fms-like tyrosine kinase-1) and PlGF (placental growth factor) indicating severity of preeclampsia (PE) for occurrence and extent of impaired postpartum kidney function. Study Design. In this prospective, single center study 44 PE patients were compared to 39 healthy controls (similar in age and gestational age with singleton pregnancy) evaluated at time of delivery and at 6 months and 12 months postpartum. p values below 0.05 are considered statistically significant. Results. The majority of the PE patients had persistence of proteinuria (>120 mg/L after delivery) 6 months (p = 0.02) and 12 months postpartum (p < 0.0001) compared to controls. Also reduced GFR (glomerular filtration rate) persisted up to 6 months postpartum in PE patients compared to controls (p < 0.001). Prepartum sFlt-1 levels indeed correlated with impaired renal function parameters. Conclusion. A significant proportion of our PE patients had lower GFR levels and persistent proteinuria up to 12 months postpartum. Prepartum sFlt-1 is a trend-setting marker for impaired renal function postpartum, but it is not sufficient enough to predict renal impairment after PE. An evaluation of 24-month follow-up data is scheduled.
authors: Department of Obstetrics and Gynaecology, Heinrich-Heine-University Medical Centre, Moorenstrasse 5, 40225 Duesseldorf, Germany.
authors: T
authors: 0000-0001-7319-4908
authors: T
authors: Kaleta
authors: Department of Obstetrics and Gynaecology, Heinrich-Heine-University Medical Centre, Moorenstrasse 5, 40225 Duesseldorf, Germany.
authors: A
authors: A
authors: Stock
authors: Department of Obstetrics and Gynecology, Dormagen Hospital, Dr.-Geldmacher-Straße 20, 41540 Dormagen, Germany.
authors: D
authors: D
authors: Panayotopoulos
authors: Department of Nephrology, DKD Helios Clinic Wiesbaden GbR, Aukammallee 33, 65191 Wiesbaden, Germany.
authors: O
authors: O
authors: Vonend
authors: Department of Obstetrics and Gynaecology, Heinrich-Heine-University Medical Centre, Moorenstrasse 5, 40225 Duesseldorf, Germany.
authors: D
authors: 0000-0001-6231-9226
authors: D
authors: Niederacher
authors: Department of Obstetrics and Gynaecology, Heinrich-Heine-University Medical Centre, Moorenstrasse 5, 40225 Duesseldorf, Germany.
authors: M
authors: 0000-0003-3799-5446
authors: M
authors: Neumann
authors: Department of Obstetrics and Gynaecology, Heinrich-Heine-University Medical Centre, Moorenstrasse 5, 40225 Duesseldorf, Germany.
authors: T
authors: T
authors: Fehm
authors: Department of Mathematics, Faculty of Mathematics and Natural Sciences, Heinrich-Heine-University, Universitätsstrasse 1, 40225 Düsseldorf, Germany.
authors: W
authors: W
authors: Kaisers
authors: Department of Obstetrics and Gynaecology, Helios University Medical Center Wuppertal, Heusnerstraße 40, 42283 Wuppertal, Germany.
authors: M
authors: 0000-0002-8966-4721
authors: M
authors: Fleisch
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000378:metabolism*; D016022:Case-Control Studies; D005260:Female; D005500:Follow-Up Studies; D005858:Germany / Q000453:epidemiology; D005919:Glomerular Filtration Rate; D006801:Humans; D007677:Kidney Function Tests; D000072483:Placenta Growth Factor / Q000378:metabolism*; D049590:Postpartum Period; D011225:Pre-Eclampsia / Q000503:physiopathology*; D011237:Predictive Value of Tests; D011247:Pregnancy; D015995:Prevalence; D011446:Prospective Studies; D051437:Renal Insufficiency / Q000175:diagnosis* / Q000453:epidemiology / Q000378:metabolism; D040281:Vascular Endothelial Growth Factor Receptor-1 / Q000378:metabolism*; D055815:Young Adult
chemical_list: D015415:Biomarkers; D000072483:Placenta Growth Factor; C501162:FLT1 protein, human; D040281:Vascular Endothelial Growth Factor Receptor-1