title: Collective cell migration: Implications for wound healing and cancer invasion.
abstract: During embryonic morphogenesis, wound repair and cancer invasion, cells often migrate collectively via tight cell-cell junctions, a process named collective migration. During such migration, cells move as coherent groups, large cell sheets, strands or tubes rather than individually. One unexpected finding regarding collective cell migration is that being a "multicellular structure" enables cells to better respond to chemical and physical cues, when compared with isolated cells. This is important because epithelial cells heal wounds via the migration of large sheets of cells with tight intercellular connections. Recent studies have gained some mechanistic insights that will benefit the clinical understanding of wound healing in general. In this review, we will briefly introduce the role of collective cell migration in wound healing, regeneration and cancer invasion and discuss its underlying mechanisms as well as implications for wound healing.
authors: Department of Respiratory Diseases, Daping Hospital, Third Military Medical University, Chongqing, 400042 ; State Key Laboratory of Trauma, Burns and Combined Injury, Institute of Surgery Research, Daping Hospital, Third Military Medical University, No.10 Changjiang Branch Road, Daping Main Street, Yuzhong District, Chongqing, 400042 P.R. China.
authors: Li
authors: L
authors: Li
authors: Department of Respiratory Diseases, Daping Hospital, Third Military Medical University, Chongqing, 400042.
authors: Yong
authors: Y
authors: He
authors: Department of Dermatology, Institute for Regenerative Cures, University of California, Davis, CA 95817 USA.
authors: Min
authors: M
authors: Zhao
authors: State Key Laboratory of Trauma, Burns and Combined Injury, Institute of Surgery Research, Daping Hospital, Third Military Medical University, No.10 Changjiang Branch Road, Daping Main Street, Yuzhong District, Chongqing, 400042 P.R. China.
authors: Jianxin
authors: J
authors: Jiang
keywords: E-cadherin; Wound healing; cancer invasion; collective migration; mechanical force Introduction