title: Intraductal Oncocytic Papillary Neoplasms of the Pancreas.
abstract: Intraductal oncocytic papillary neoplasms (IOPNs) are cystic neoplasms with intraductal growth and complex papillae composed of oncocytic cells. IOPNs have been reported both in the pancreas and biliary tree, and are most likely closely related in these 2 locations. In the pancreas, these rare tumors are now considered 1 of the 4 histologic subtypes of intraductal papillary mucinous neoplasm (IPMN). Significant differences in histology, immunophenotype, and molecular genetics have been reported between IOPNs and other IPMN subtypes. However, there are limited data regarding the clinical behavior and prognosis of IOPNs in comparison to other subtypes of IPMN. We review features of pancreatic IOPNs and discuss the differential diagnosis of other intraductal lesions in the pancreas.
authors: Michael E
authors: ME
authors: Kallen
authors: From the Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles.
authors: Bita V
authors: BV
authors: Naini
mesh_terms: D018249:Adenoma, Oxyphilic / Q000175:diagnosis / Q000235:genetics / Q000473:pathology* / Q000601:surgery; D021441:Carcinoma, Pancreatic Ductal / Q000175:diagnosis / Q000235:genetics / Q000473:pathology* / Q000601:surgery; D002291:Carcinoma, Papillary / Q000175:diagnosis / Q000235:genetics / Q000473:pathology* / Q000601:surgery; D003937:Diagnosis, Differential; D006801:Humans; D009154:Mutation; D010179:Pancreas / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D010190:Pancreatic Neoplasms / Q000175:diagnosis / Q000235:genetics / Q000473:pathology* / Q000601:surgery; D011379:Prognosis; D016283:Proto-Oncogene Proteins p21(ras) / Q000235:genetics
chemical_list: C117307:KRAS protein, human; D016283:Proto-Oncogene Proteins p21(ras)