title: Antineutrophil Cytoplasmic Antibody-associated Vasculitis Superimposed on Infection-related Glomerulonephritis Secondary to Pulmonary Mycobacterium avium Complex Infection.
abstract: A 73-year-old woman was diagnosed with pulmonary Mycobacterium avium complex (MAC) infection and received no treatment. Disease progression was evident one year later with the development of myeloperoxidase-antineutrophil cytoplasmic antibody (ANCA) titers and systemic symptoms of a fever, polyarthritis, purpura, and rapidly progressive glomerulonephritis. Her symptoms did not improve with antibiotic treatment. A renal biopsy revealed crescentic glomerulonephritis with immunodeposition. According to these findings, she was diagnosed with ANCA-associated vasculitis (AAV) superimposed on infection-related glomerulonephritis (IRGN). Although there was a risk of aggravating an underlying infection, the combination therapy of corticosteroid and antibiotics improved AAV, IRGN, and even the lung radiological findings. To the best of our knowledge, this is the first case of AAV and IRGN secondary to pulmonary MAC infection.
authors: Department of Respiratory Medicine, Nagoya University Graduate School of Medicine, Japan.
authors: Shuichi
authors: S
authors: Asano
authors: Shige
authors: S
authors: Mizuno
authors: Shotaro
authors: S
authors: Okachi
authors: Hiromichi
authors: H
authors: Aso
authors: Keiko
authors: K
authors: Wakahara
authors: Naozumi
authors: N
authors: Hashimoto
authors: Satoru
authors: S
authors: Ito
authors: Yohei
authors: Y
authors: Kozaki
authors: Takayuki
authors: T
authors: Katsuno
authors: Shoichi
authors: S
authors: Maruyama
authors: Yoshinori
authors: Y
authors: Hasegawa
mesh_terms: D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000368:Aged; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D056648:Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis / Q000209:etiology*; D018450:Disease Progression; D005260:Female; D005921:Glomerulonephritis / Q000209:etiology* / Q000382:microbiology; D006801:Humans; D015270:Mycobacterium avium-intracellulare Infection / Q000150:complications* / Q000188:drug therapy; D018410:Pneumonia, Bacterial / Q000150:complications* / Q000188:drug therapy / Q000382:microbiology
chemical_list: D000305:Adrenal Cortex Hormones; D000900:Anti-Bacterial Agents