title: A clinical evaluation of renal amyloidosis in the Japan renal biopsy registry: a cross-sectional study.
abstract: OBJECTIVE
  The available clinical data are limited in a rare glomerular disease, renal amyloidosis. We aimed to clarify the clinical features of renal amyloidosis from database of the Japan Renal Biopsy Registry (J-RBR).
  
  
  METHODS
  We performed a cross-sectional study with database of the J-RBR of the Japanese Society of Nephrology. We identified 281 cases of renal amyloidosis from 20,997 cases enrolled into the J-RBR from 2007 to 2014. Systolic blood pressure (SBP) and diastolic blood pressure (DBP) were compared among the levels of ages, amount of urine protein excretion (AUPE) or CKD G stages.
  
  
  RESULTS
  The prevalence of renal amyloidosis was 1.3 % (281/20,997). DBP significantly decreased in higher age quartiles (P = 0.034). SBP and DBP did not increase in the progression of AUPE levels and CKD G stages. In multiple regression analysis, eGFR was a significant independent factor for SBP in all cases and a subgroup without hypertensive agents. There was a reverse significant relationship between SBP and eGFR.
  
  
  CONCLUSIONS
  Blood pressure did not significantly increase in elderly and much proteinuric condition in renal amyloidosis. The progression of CKD and decrease of eGFR did not produce the higher SBP. The mechanism underlying these results remains unclear; however, they are unique features of renal amyloidosis. The couple of hypotensive and hypertensive conditions might produce no relationship between blood pressure and CKD stages.
authors: Division of Nephrology and Kidney Center, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki, Chuo-ku, Kobe, Hyogo, 650-0017, Japan. snishi@med.kobe-u.ac.jp.
authors: Shinichi
authors: S
authors: Nishi
authors: Center of Nephrology and Urology, Division of Nephrology and Dialysis, Kitano Hospital, The Tazuke Kofukai Medical Research Institute, 2-4-20 Ohgimachi, Kita-ku, Osaka, 530-8480, Japan.
authors: Eri
authors: E
authors: Muso
authors: Department of Analytic Human Pathology, Nippon Medical School, 1-1-5, Sendagi, Tokyo, 113-8602, Japan.
authors: Akira
authors: A
authors: Shimizu
authors: Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Science, 2-5-1 Shikata, Okayama, 700-8558, Japan.
authors: Hitoshi
authors: H
authors: Sugiyama
authors: Department of Nephrology, Kanazawa Medical University School of Medicine, 1-1 Daigaku, Uchinada, Ishikawa, 920-0293, Japan.
authors: Hitoshi
authors: H
authors: Yokoyama
authors: Department of Neurology, Department of Diagnostic Medicine, Graduate School of Medical Science, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto, 860-8556, Japan.
authors: Yukio
authors: Y
authors: Ando
authors: Division of Nephrology and Kidney Center, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki, Chuo-ku, Kobe, Hyogo, 650-0017, Japan.
authors: Shunsuke
authors: S
authors: Goto
authors: Division of Nephrology and Kidney Center, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki, Chuo-ku, Kobe, Hyogo, 650-0017, Japan.
authors: Hideki
authors: H
authors: Fujii
mesh_terms: D000368:Aged; D000686:Amyloidosis / Q000175:diagnosis* / Q000453:epidemiology / Q000473:pathology / Q000503:physiopathology; D001706:Biopsy; D001794:Blood Pressure; D003430:Cross-Sectional Studies; D018450:Disease Progression; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D007564:Japan / Q000453:epidemiology; D007678:Kidney Glomerulus / Q000473:pathology* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D015995:Prevalence; D011507:Proteinuria / Q000453:epidemiology / Q000473:pathology / Q000503:physiopathology; D012042:Registries; D051436:Renal Insufficiency, Chronic / Q000175:diagnosis* / Q000453:epidemiology / Q000473:pathology / Q000503:physiopathology; D012307:Risk Factors; D012720:Severity of Illness Index
keywords: Amyloidosis; Blood pressure; Chronic kidney disease; Nephrotic syndrome