title: Serum interleukin-17 in Egyptian children with systemic lupus erythematosus: is it related to pulmonary affection?
abstract: Objective Pulmonary involvement in paediatric systemic lupus erythematosus (pSLE) is not an uncommon finding; however, subclinical affection occurs more frequently. Many studies have reported that cytokine dysregulation as interleukin-17 (IL-17) over-expression plays a key role in the pathogenesis of systemic lupus erythematosus (SLE). We aim to assess serum levels of IL-17 A and their association with pulmonary involvement in children with SLE. Methods Serum IL-17A levels - determined by solid phase sandwich ELISA - were assessed in forty-two pSLE patients and compared to 45 age-matched healthy controls. All patients were subjected to pulmonary function tests to detect subclinical pulmonary affection. High-resolution CT (HRCT) chest scan was carried out in patients with abnormal pulmonary function tests (PFTs) and those with chronic respiratory symptoms. Results Abnormal PFTs were found in 73% of patients; of them, only 25% had abnormal findings in HRCT chest. Serum levels of IL-17 A were significantly elevated in pSLE patients as compared to healthy controls ( p < 0.001). The serum levels of IL-17 A had a highly significant positive correlation with SLEDAI ( r = 0.811 and p < 0.001) Strong negative correlation was found between serum levels of IL-17A with both FEV1 and FVC ( p < 0.05). Conclusions Serum IL-17A is elevated in pSLE patients, which correlates with disease activity. IL-17 seems to have a possible role in the pathogenesis of subclinical lung affection. Abnormal PFTS may be found in pSLE patients even with normal radiology.
authors: 1 Pediatric Nephrology Unit, Department of Pediatrics, Faculty of Medicine, Mansoura University, Egypt.
authors: A
authors: A
authors: Hammad
authors: 2 Pediatric Allergy and Clinical Immunology Unit, Faculty of Medicine, Mansoura University, Egypt.
authors: E
authors: E
authors: Osman
authors: 3 Clinical Immunology Unit, Clinical Pathology Department, Faculty of Medicine, Mansoura University, Egypt.
authors: Y
authors: Y
authors: Mosaad
authors: 4 Pediatric Department, Faculty of Medicine, Mansoura University, Egypt.
authors: M
authors: M
authors: Wahba
mesh_terms: D000293:Adolescent; D002648:Child; D003430:Cross-Sectional Studies; D004534:Egypt; D005260:Female; D006801:Humans; D020381:Interleukin-17 / Q000097:blood* / Q000276:immunology; D008171:Lung Diseases / Q000097:blood* / Q000276:immunology / Q000503:physiopathology; D008180:Lupus Erythematosus, Systemic / Q000097:blood* / Q000276:immunology / Q000503:physiopathology*; D008297:Male; D012129:Respiratory Function Tests
chemical_list: C508717:IL17A protein, human; D020381:Interleukin-17
keywords: Interleukin -17 A; lupus; paediatrics; pulmonary affection