title: Dietary Cerebroside from Sea Cucumber (Stichopus japonicus): Absorption and Effects on Skin Barrier and Cecal Short-Chain Fatty Acids.
abstract: Sphingolipids from marine sources have attracted more attention recently because of their distinctive structures and expected functions. In this study, the content and components of cerebroside from sea cucumber Stichopus japonicus were analyzed. The absorption of cerebroside from S. japonicus was investigated with an in vivo lipid absorption assay. The result revealed that S. japonicus is a rich source of cerebroside that contained considerable amounts of odd carbon chain sphingoid bases. The cumulative recoveries of d17:1- and d19:2-containing cerebrosides were 0.31 ± 0.16 and 0.32 ± 0.10%, respectively, for 24 h after administration. To the best of the authors' knowledge, this is the first work that shows sphingolipids from a marine source could be absorbed in vivo and incorporated into ceramides. In addition, dietary supplementation with sea cucumber cerebroside to hairless mouse improved the skin barrier function and increased short-chain fatty acids in cecal contents, which have shown beneficial effects on the host.
authors: Division of Applied Biosciences, Graduate School of Agriculture, Kyoto University , Kyoto 606-8502, Japan.|Department of Cardiology, Boston Children's Hospital , Boston, Massachusetts 02115, United States.
authors: Jingjing
authors: J
authors: Duan
authors: Division of Applied Biosciences, Graduate School of Agriculture, Kyoto University , Kyoto 606-8502, Japan.
authors: Marina
authors: M
authors: Ishida
authors: Innovation Center, Nippon Flour Mills Co., Ltd. , Atsugi 243-0041, Japan.
authors: Kazuhiko
authors: K
authors: Aida
authors: Laboratory of Food and Biomolecular Science, Graduate School of Agricultural Science, Tohoku University , Sendai 981-8555, Japan.
authors: Tsuyoshi
authors: T
authors: Tsuduki
authors: Department of Cardiology, Boston Children's Hospital , Boston, Massachusetts 02115, United States.
authors: Jin
authors: J
authors: Zhang
authors: Division of Applied Biosciences, Graduate School of Agriculture, Kyoto University , Kyoto 606-8502, Japan.
authors: Yuki
authors: Y
authors: Manabe
authors: Division of Applied Biosciences, Graduate School of Agriculture, Kyoto University , Kyoto 606-8502, Japan.|Shijonawate Gakuen University , Daito 574-0011, Japan.
authors: Takashi
authors: T
authors: Hirata
authors: Division of Applied Biosciences, Graduate School of Agriculture, Kyoto University , Kyoto 606-8502, Japan.
authors: Tatsuya
authors: T
authors: Sugawara
mesh_terms: D000818:Animals; D002432:Cecum / Q000737:chemistry / Q000378:metabolism*; D002554:Cerebrosides / Q000737:chemistry / Q000378:metabolism*; D019587:Dietary Supplements / Q000032:analysis; D005232:Fatty Acids, Volatile / Q000737:chemistry / Q000378:metabolism*; D005260:Female; D008297:Male; D051379:Mice; D008812:Mice, Hairless; D051381:Rats; D017207:Rats, Sprague-Dawley; D012867:Skin / Q000737:chemistry / Q000378:metabolism*; D047528:Stichopus / Q000737:chemistry*
chemical_list: D002554:Cerebrosides; D005232:Fatty Acids, Volatile
keywords: cerebroside; dietary sphingolipids; sea cucumber Stichopus japonicus; sphingoid base