title: Effect of Bioregulators Isolated from Rat Liver and Blood Serum on the State of Murine Liver in Roller Organotypic Culture after CCl4-Induced Fibrosis.
abstract: We studied the protective effect of bioregulators isolated from the liver and blood serum of mammals under conditions of manifest fibrosis. Fibrosis was induced by CCl4 administration for 30 days and then, the liver was cultured in a roller organotypic culture for 30 days in the presence of bioregulators. Hepatoprotective effect of bioregulators was evaluated on histological sections of the liver at different terms of culturing. Experiments with roller organotypic culture of the liver isolated from animals with in vivo CCl4-induced fibrosis demonstrated the protective effect of bioregulator of the liver origin, while bioregulator isolated from the blood was ineffective.
authors: M. V. Lomonosov Moscow State University, Moscow, Russia. denis.nalobin@gmail.com.
authors: D S
authors: DS
authors: Nalobin
authors: A. N. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, Moscow, Russia.
authors: M S
authors: MS
authors: Krasnov
authors: M. V. Lomonosov Moscow State University, Moscow, Russia.
authors: S I
authors: SI
authors: Alipkina
authors: N. K. Kol'tsov Institute of Developmental Biology, Russian Academy of Sciences, Moscow, Russia.
authors: M S
authors: MS
authors: Syrchina
authors: N. K. Kol'tsov Institute of Developmental Biology, Russian Academy of Sciences, Moscow, Russia.
authors: V P
authors: VP
authors: Yamskova
authors: M. V. Lomonosov Moscow State University, Moscow, Russia.
authors: I A
authors: IA
authors: Yamskov
mesh_terms: D000818:Animals; D002251:Carbon Tetrachloride / Q000633:toxicity*; D005260:Female; D008099:Liver / Q000187:drug effects* / Q000378:metabolism*; D008103:Liver Cirrhosis / Q000097:blood* / Q000139:chemically induced / Q000378:metabolism*; D008297:Male; D051379:Mice; D009924:Organ Culture Techniques; D051381:Rats; D017208:Rats, Wistar
chemical_list: D002251:Carbon Tetrachloride
keywords: bioregulators; fibrosis; liver; organotypic culturing