title: Computer modelling of bone's adaptation: the role of normal strain, shear strain and fluid flow.
abstract: Bone loss is a serious health problem. In vivo studies have found that mechanical stimulation may inhibit bone loss as elevated strain in bone induces osteogenesis, i.e. new bone formation. However, the exact relationship between mechanical environment and osteogenesis is less clear. Normal strain is considered as a prime stimulus of osteogenic activity; however, there are some instances in the literature where osteogenesis is observed in the vicinity of minimal normal strain, specifically near the neutral axis of bending in long bones. It suggests that osteogenesis may also be induced by other or secondary components of mechanical environment such as shear strain or canalicular fluid flow. As it is evident from the literature, shear strain and fluid flow can be potent stimuli of osteogenesis. This study presents a computational model to investigate the roles of these stimuli in bone adaptation. The model assumes that bone formation rate is roughly proportional to the normal, shear and fluid shear strain energy density above their osteogenic thresholds. In vivo osteogenesis due to cyclic cantilever bending of a murine tibia has been simulated. The model predicts results close to experimental findings when normal strain, and shear strain or fluid shear were combined. This study also gives a new perspective on the relation between osteogenic potential of micro-level fluid shear and that of macro-level bending shear. Attempts to establish such relations among the components of mechanical environment and corresponding osteogenesis may ultimately aid in the development of effective approaches to mitigating bone loss.
authors: School of Mechanical Materials and Energy Engineering, Indian Institute of Technology Ropar, Room No. 303, Nangal Road, Rupnagar, Punjab, 140001, India.
authors: Abhishek Kumar
authors: AK
authors: Tiwari
authors: School of Mechanical Materials and Energy Engineering, Indian Institute of Technology Ropar, Room No. 303, Nangal Road, Rupnagar, Punjab, 140001, India. jprasad@iitrpr.ac.in.
authors: Jitendra
authors: J
authors: Prasad
mesh_terms: D000222:Adaptation, Physiological; D000818:Animals; D001842:Bone and Bones / Q000502:physiology*; D003198:Computer Simulation; D051379:Mice; D008954:Models, Biological; D010012:Osteogenesis; D013314:Stress, Mechanical
keywords: Bone Loss; Fluid Flow; Normal Strain; Osteogenesis; Shear Strain