title: Concomitance of monosomal karyotype with at least 5 chromosomal abnormalities is associated with dismal treatment outcome of AML patients with complex karyotype - retrospective analysis of Polish Adult Leukemia Group (PALG).
abstract: Monosomal karyotype (MK) and complex karyotype (CK) are poor prognostic factors in acute myeloid leukemia (AML). A comprehensive analysis of cytogenetic and clinical factors influencing an outcome of AML-CK+was performed. The impact of cladribine containing induction on treatment results was also evaluated. We analyzed 125 patients with AML-CK+treated within PALG protocols. MK was found in 75 (60%) individuals. The overall complete remission (CR) rate of 66 intensively treated patients was 62% vs. 28% in CK+MK-and CK+MK+group (p = .01). No difference in CR rate was observed between DA and DAC arms. The overall survival (OS) in intensively treated patients was negatively influenced by MK, karyotype complexity (≥5 abnormalities), and WBC >20 G/L in multivariate analysis. The addition of cladribine to DA regimen improved OS only in MK-but not in MK+group. In conclusion, concomitance of MK with ≥5 chromosomal abnormalities is associated with dismal treatment outcome in AMK-CK+.
authors: a Department of Hematology , Medical University of Lodz , Lodz , Poland.
authors: Agnieszka
authors: A
authors: Wierzbowska
authors: a Department of Hematology , Medical University of Lodz , Lodz , Poland.
authors: Ewa
authors: E
authors: Wawrzyniak
authors: b Department of Hematology , Copernicus Memorial Hospital , Lodz , Poland.
authors: Monika
authors: M
authors: Siemieniuk-Rys
authors: b Department of Hematology , Copernicus Memorial Hospital , Lodz , Poland.
authors: Aleksandra
authors: A
authors: Kotkowska
authors: a Department of Hematology , Medical University of Lodz , Lodz , Poland.
authors: Agnieszka
authors: A
authors: Pluta
authors: b Department of Hematology , Copernicus Memorial Hospital , Lodz , Poland.
authors: Aleksandra
authors: A
authors: Golos
authors: a Department of Hematology , Medical University of Lodz , Lodz , Poland.
authors: Tadeusz
authors: T
authors: Robak
authors: c Department of Hematology , Blood Malignancies and Bone Marrow Transplantation, Medical University of Wroclaw , Wroclaw , Poland.
authors: Marta
authors: M
authors: Szarawarska
authors: c Department of Hematology , Blood Malignancies and Bone Marrow Transplantation, Medical University of Wroclaw , Wroclaw , Poland.
authors: Anna
authors: A
authors: Jaskowiec
authors: c Department of Hematology , Blood Malignancies and Bone Marrow Transplantation, Medical University of Wroclaw , Wroclaw , Poland.
authors: Ewa
authors: E
authors: Duszenko
authors: c Department of Hematology , Blood Malignancies and Bone Marrow Transplantation, Medical University of Wroclaw , Wroclaw , Poland.
authors: Justyna
authors: J
authors: Rybka
authors: d Department of Hematology , WSS , Legnica , Poland.
authors: Jadwiga
authors: J
authors: Holojda
authors: e Department of Hematology , ZSM of Chorzow , Chorzow , Poland.
authors: Sebastian
authors: S
authors: Grosicki
authors: f Cancer Genetics Laboratory of Pathology Department , M Sklodowska-Curie Memorial Cancer Center and Institute , Warsaw , Poland.
authors: Barbara
authors: B
authors: Pienkowska-Grela
authors: f Cancer Genetics Laboratory of Pathology Department , M Sklodowska-Curie Memorial Cancer Center and Institute , Warsaw , Poland.
authors: Renata
authors: R
authors: Woroniecka
authors: g Department of Hematology , Institute of Hematology and Blood Transfusion , Warsaw , Poland.
authors: Anna
authors: A
authors: Ejduk
authors: h Department of Hematology , Holycross Cancer Center , Kielce , Poland.
authors: Marzena
authors: M
authors: Watek
authors: i Department of Hematooncology and Bone Marrow Transplantation , Medical University of Lublin , Lublin , Poland.
authors: Malgorzata
authors: M
authors: Wach
authors: j Department of Clinical Genetics , Collegium Medicum of Nicolaus Copernicus University , Bydgoszcz , Poland.
authors: Barbara
authors: B
authors: Mucha
authors: j Department of Clinical Genetics , Collegium Medicum of Nicolaus Copernicus University , Bydgoszcz , Poland.
authors: Katarzyna
authors: K
authors: Skonieczka
authors: k Department of Hematology , Nicolaus Copernicus Municipal Specialist Hospital , Torun , Poland.
authors: Maria
authors: M
authors: Czyzewska
authors: l Department of Hematology , Medical University of Bydgoszcz , Bydgoszcz , Poland.
authors: Anna
authors: A
authors: Jachalska
authors: m Department of Biology and Genetics , Medical University of Gdansk , Gdansk , Poland.
authors: Agnieszka
authors: A
authors: Klonowska
authors: m Department of Biology and Genetics , Medical University of Gdansk , Gdansk , Poland.
authors: Mariola
authors: M
authors: Iliszko
authors: n Department of Hematology , SP ZOZ WMCO Oncology Center , Olsztyn , Poland.
authors: Wanda
authors: W
authors: Knopinska-Posluszny
authors: o Institute of Human Genetics, PAN , Poznan , Poland.|p Department of Hematology and Bone Marrow Transplantation , University of Medical Sciences , Poznan , Poland.
authors: Malgorzata
authors: M
authors: Jarmuz-Szymczak
authors: p Department of Hematology and Bone Marrow Transplantation , University of Medical Sciences , Poznan , Poland.
authors: Anna
authors: A
authors: Przybylowicz-Chalecka
authors: p Department of Hematology and Bone Marrow Transplantation , University of Medical Sciences , Poznan , Poland.
authors: Lidia
authors: L
authors: Gil
authors: q Department of Hematology , Oncology Center, Municipal Hospital , Rzeszow , Poland.
authors: Agnieszka
authors: A
authors: Kopacz
authors: r Department of Bone Marrow Transplantation , M. Sklodowska-Curie Institute of Oncology , Gliwice , Poland.
authors: Jerzy
authors: J
authors: Holowiecki
authors: c Department of Hematology , Blood Malignancies and Bone Marrow Transplantation, Medical University of Wroclaw , Wroclaw , Poland.|j Department of Clinical Genetics , Collegium Medicum of Nicolaus Copernicus University , Bydgoszcz , Poland.
authors: Olga
authors: O
authors: Haus
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use; D015415:Biomarkers; D002869:Chromosome Aberrations; D003131:Combined Modality Therapy; D005260:Female; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D059785:Karyotype; D015470:Leukemia, Myeloid, Acute / Q000235:genetics* / Q000401:mortality* / Q000628:therapy; D008297:Male; D008875:Middle Aged; D009006:Monosomy; D011044:Poland; D011379:Prognosis; D012189:Retrospective Studies; D016019:Survival Analysis; D014184:Transplantation, Homologous; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D015415:Biomarkers
keywords: Acute myeloid leukemia; cladribine; complex karyotype; monosomal karyotype; prognosis