title: Animal models of hypoxic-ischemic encephalopathy: optimal choices for the best outcomes.
abstract: Hypoxic-ischemic encephalopathy (HIE), a serious disease leading to neonatal death, is becoming a key area of pediatric neurological research. Despite remarkable advances in the understanding of HIE, the explicit pathogenesis of HIE is unclear, and well-established treatments are absent. Animal models are usually considered as the first step in the exploration of the underlying disease and in evaluating promising therapeutic interventions. Various animal models of HIE have been developed with distinct characteristics, and it is important to choose an appropriate animal model according to the experimental objectives. Generally, small animal models may be more suitable for exploring the mechanisms of HIE, whereas large animal models are better for translational studies. This review focuses on the features of commonly used HIE animal models with respect to their modeling strategies, merits, and shortcomings, and associated neuropathological changes, providing a comprehensive reference for improving existing animal models and developing new animal models.
authors: Lan
authors: L
authors: Huang
authors: Fengyan
authors: F
authors: Zhao
authors: Yi
authors: Y
authors: Qu
authors: Li
authors: L
authors: Zhang
authors: Yan
authors: Y
authors: Wang
authors: Dezhi
authors: D
authors: Mu
mesh_terms: D000818:Animals; D001930:Brain Injuries / Q000628:therapy*; D002755:Choice Behavior / Q000502:physiology*; D004195:Disease Models, Animal; D006801:Humans; D020925:Hypoxia-Ischemia, Brain / Q000503:physiopathology*; D009474:Neurons / Q000473:pathology