title: Mapping Billions of Short Reads to a Reference Genome.
abstract: Rapid development and commercialization of instruments that can accurately, rapidly, and cheaply sequence billions of DNA bases is revolutionizing molecular biology and medicine. Because a reference genome is usually available, the first bioinformatics challenge presented by the new generation of high-throughput sequencers is the genome mapping problem, where each read is mapped to a reference genome to reveal its location(s). An introduction to mapping algorithms, as well as factors that influence their results, is provided here.
authors: Jui-Hung
authors: JH
authors: Hung
authors: Zhiping
authors: Z
authors: Weng
mesh_terms: D019295:Computational Biology / Q000379:methods*; D016678:Genome; D059014:High-Throughput Nucleotide Sequencing / Q000379:methods*; D017422:Sequence Analysis, DNA / Q000379:methods*