title: Low dose of lipopolysaccharide pretreatment can alleviate the in?ammatory response in wound infection mouse model.
abstract: To assess the effects of lipopolysaccharide (LPS) pretreatment on wound infection mouse model and evaluate the biological safety of the optimal pretreatment dose in vivo.
  
  
  
  Mice were pretreated with LPS of different doses at 48 and 24 h before femoral medial lon- gitudinal incision was made and infected with different bacteria.
  
  
  
  It is showed that 0.5 mg/kg/time of LPS pretreatment can significantly alleviate the inflammation in mouse model infected with methicillin-resistances Staphylococcus aureus, methicillin-sensitive S. aureus, Pseudomonas aeruginosa,or Escherichia coli compared with doses of 0.25 mg/kg/time, 1 mg/ kg/time, and 1.5 mg/kg/time.
  
  
  
  LPS pretreatment can alleviate the inflammation in mouse model and the optimal dose is 0.5 mg/kg/time, and meanwhile it does not damage organs' function.
authors: Department of Orthopedics, Beijing Chao-Yang Hospital, Beijing 100020, China.
authors: Dong
authors: D
authors: Wang
authors: Yang
authors: Y
authors: Liu
authors: Yan-Rui
authors: YR
authors: Zhao
authors: Jun-Lin
authors: JL
authors: Zhou
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D005260:Female; D007249:Inflammation / Q000517:prevention & control*; D008070:Lipopolysaccharides / Q000627:therapeutic use*; D051379:Mice; D008807:Mice, Inbred BALB C; D013530:Surgical Wound Infection / Q000188:drug therapy*; D051197:Toll-Like Receptor 4 / Q000502:physiology
chemical_list: D008070:Lipopolysaccharides; C493487:Tlr4 protein, mouse; D051197:Toll-Like Receptor 4