title: A multivariable model to predict survival for patients with hepatic carcinoma or liver metastasis receiving radiotherapy.
abstract: OBJECTIVE
  New parameters that correlate with overall survival were identified in patients with liver lesions treated with radiation therapy.
  
  
  METHODS
  Pretreatment information and parameters of radiation treatment plans for 129 metastatic and 66 hepatocellular carcinoma liver cancer patients were analyzed. Study end points included overall survival collected from patient charts and electronic records.
  
  
  RESULTS
  Two practical nomograms were constructed for primary hepatocellular carcinoma and liver metastasis patients. For patients with a Child-Pugh A, radiation dose escalation provided a significant survival benefit. However, for those with Child-Pugh B or C, increasing dose does not impact on survival.
  
  
  CONCLUSIONS
  The developed models can potentially guide dose selection and provide prognostic information but still require external validation.
authors: Department of Medical Biophysics, Western University, London, ON, Canada.
authors: Jason
authors: J
authors: Vickress
authors: Department of Medical Biophysics, Western University, London, ON, Canada.|Department of Oncology, Western University, London, ON, Canada.|London Regional Cancer Program, London Health Sciences Centre, London, ON, Canada.
authors: Michael
authors: M
authors: Lock
authors: Department of Radiation Oncology, University of Washington School of Medicine, Seattle, WA, USA.
authors: Simon
authors: S
authors: Lo
authors: Department of Medical Biophysics, Western University, London, ON, Canada.|Department of Oncology, Western University, London, ON, Canada.|London Regional Cancer Program, London Health Sciences Centre, London, ON, Canada.
authors: Stewart
authors: S
authors: Gaede
authors: Department of Oncology, Western University, London, ON, Canada.
authors: Aaron
authors: A
authors: Leung
authors: Department of Oncology, Western University, London, ON, Canada.|London Regional Cancer Program, London Health Sciences Centre, London, ON, Canada.
authors: Jeff
authors: J
authors: Cao
authors: Department of Medical Biophysics, Western University, London, ON, Canada.|Department of Oncology, Western University, London, ON, Canada.|London Regional Cancer Program, London Health Sciences Centre, London, ON, Canada.
authors: Rob
authors: R
authors: Barnett
authors: Department of Medical Biophysics, Western University, London, ON, Canada.|Department of Oncology, Western University, London, ON, Canada.|London Regional Cancer Program, London Health Sciences Centre, London, ON, Canada.
authors: Slav
authors: S
authors: Yartsev
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers; D006528:Carcinoma, Hepatocellular / Q000175:diagnosis / Q000401:mortality* / Q000532:radiotherapy*; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D008113:Liver Neoplasms / Q000175:diagnosis / Q000401:mortality* / Q000532:radiotherapy* / Q000556:secondary; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D060787:Neoplasm Grading; D049451:Nomograms; D011379:Prognosis; D047368:Tumor Burden
chemical_list: D015415:Biomarkers
keywords: liver cancer; nomograms; radiation therapy; treatment outcomes