title: MicroRNAs and Inflammation in Colorectal Cancer.
abstract: Colorectal cancers (CRC) are known to be related to inflammatory conditions, and inflammatory bowel diseases increase the relative risk for developing CRC. The use of anti-inflammatory drugs prevents the development of colorectal cancer.Several molecular mediators are connecting the pathways that are involved in inflammatory conditions and in carcinogenesis. By the way these pathways are tightly interwoven, with the consequence that a deregulation at the level of any of these molecular mediators can affect the others.MiRNAs are demonstrated to be deregulated in inflammatory bowel diseases and in colorectal cancer. Moreover, they target several molecular mediators that connect inflammation to cancer, and they are thus implicated in the route from inflammation to colorectal cancer.This chapter will focus on the miRNAs that are jointly deregulated in inflammatory bowel disease and in colorectal cancer. Their role on the regulation of the molecular mediators and pathways that link inflammation to cancer will be described.
authors: University of Liège, GIGA-Research, Laboratory of Human Genetics, Liège, Belgium. c.josse@ulg.ac.be.
authors: Claire
authors: C
authors: Josse
authors: Human Genetics Department, University Hospital Centre of Liège, CHU, Liège, Belgium.
authors: Vincent
authors: V
authors: Bours
mesh_terms: D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D063646:Carcinogenesis; D015179:Colorectal Neoplasms / Q000209:etiology / Q000235:genetics* / Q000473:pathology / Q000517:prevention & control; D016207:Cytokines / Q000502:physiology; D004249:DNA Damage; D004198:Disease Susceptibility; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D007249:Inflammation; D036341:Intercellular Signaling Peptides and Proteins / Q000502:physiology; D035683:MicroRNAs / Q000235:genetics*; D009363:Neoplasm Proteins / Q000502:physiology; D018384:Oxidative Stress; D012334:RNA, Neoplasm / Q000235:genetics*; D015398:Signal Transduction; D014157:Transcription Factors / Q000502:physiology
chemical_list: D000893:Anti-Inflammatory Agents; D016207:Cytokines; D036341:Intercellular Signaling Peptides and Proteins; D035683:MicroRNAs; D009363:Neoplasm Proteins; D012334:RNA, Neoplasm; D014157:Transcription Factors
keywords: CAC; Colorectal cancer; IBD; Inflammation; Inflammatory bowel disease; microRNAs