title: Hydractinia echinata test-system. IV. Toxic synergism of human pharmaceuticals in mixtures with iodoform.
abstract: The structure-toxicity relationships for a series of singular human stomatological pharmaceuticals preparations and in mixture with Iodoform on Hydractinia echinata were obtained and their synergism was analyzed through the Metamorphosis Reduction Concentration (MRC50) within the "Köln model". The differences manifested between the total and individual components of the samples and mixtures, associated with toxic versus non-toxic synergism, are dependent on three essential factors of synthesis (the nature, the concentration and the number) besides manifested isotoxicity of the given components. The method represents a practical alternative useful for the reduction of experimental tests on animal to the lowest possible level, in accordance to the '3Rs' (reduce, reuse and recycle) integrative concept.
authors: Siegstr. 4, Köln D-50859, Germany. Electronic address: Lchi@gmx.de.
authors: Sergiu A
authors: SA
authors: Chicu
authors: Hölderlinstr. 58, Köln D-50858, Germany. Electronic address: l.schannen@web.de.
authors: Ladislaus
authors: L
authors: Schannen
authors: Laboratory of Computational and Structural Physical-Chemistry for Nanosciences and QSAR, Biology-Chemistry Department, Faculty of Chemistry, Biology, Geography at West University of Timişoara, Pestalozzi Street No.16, Timişoara RO-300115, Romania. Electronic address: mv_putz@yahoo.com.
authors: Mihai V
authors: MV
authors: Putz
authors: "Victor Babes" University of Medicine and Pharmacy Timișoara, Faculty of Pharmacy, Department 1-Pharmacy, Physical Chemistry, 2 Eftimie Murgu, 300041 Timișoara, Romania. Electronic address: simu.georgeta@umft.ro.
authors: Georgeta-M
authors: GM
authors: Simu
keywords: Human pharmaceutical preparations; Hydractinia echinata-test-system (HeTS); Iodoform; Iso-toxicity; Stomatological samples; Synergism