title: Exposure to phthalates in house dust and associated allergies in children aged 6-12years.
abstract: Phthalates are widely used as plasticizers in household products. Several studies have reported an association between phthalate exposure and an increased risk of allergies. The present study estimated phthalate exposure in children aged 6-12years and assessed potential correlations with allergies. House dust samples were collected from floors and multi-surface objects >35cm above the floor. Urine samples were collected from the first morning void of the day. Daily phthalate intake (DIdustand DI) was estimated using both house dust and urinary metabolite concentrations. Exposure to di-2-ethylhexyl phthalate (DEHP) in floor dust was associated with parental-reported rhino-conjunctivitis. After stratification by gender, this trend was found to only occur in boys. Furthermore, urinary mono-isobutyl phthalate was inversely associated with parental-reported wheeze in boys. DIdustof benzyl butyl phthalate (BBzP) and DEHP were significantly correlated with DI_BBzP and DI_DEHP, respectively. These correlations were stronger with floor than with multi-surface dust. Our results suggest that, among Japanese children, house dust from low surfaces, such as living room floors, might play a meaningful role in the indoor environmental exposure pathway for BBzP and DEHP.
authors: Hokkaido University Center for Environmental and Health Sciences, Kita 12, Nishi 7, Kita-ku, Sapporo 060-0812, Japan.
authors: Yu
authors: Y
authors: Ait Bamai
authors: Hokkaido University Center for Environmental and Health Sciences, Kita 12, Nishi 7, Kita-ku, Sapporo 060-0812, Japan.
authors: Atsuko
authors: A
authors: Araki
authors: Osaka Occupational Health Service Center, Japan Industrial Safety and Health Association, 2-3-8, Tosabori, Nishi-ku, Osaka 550-0001, Japan.
authors: Toshio
authors: T
authors: Kawai
authors: Osaka Occupational Health Service Center, Japan Industrial Safety and Health Association, 2-3-8, Tosabori, Nishi-ku, Osaka 550-0001, Japan.
authors: Tazuru
authors: T
authors: Tsuboi
authors: Department of Environmental Health and Toxicology, Division of Environment Health, Tokyo Metropolitan Institute of Public Health, 3-24-1 Hyakunincho, Shinjuku-ku, Tokyo 169-0073, Japan.
authors: Ikue
authors: I
authors: Saito
authors: Hokkaido University Center for Environmental and Health Sciences, Kita 12, Nishi 7, Kita-ku, Sapporo 060-0812, Japan; Asahikawa Medical University for Department of Health Science, E2-1-1-1, Midorigaoka, Asahikawa, Hokkaido 078-8510, Japan.
authors: Eiji
authors: E
authors: Yoshioka
authors: Hokkaido University Center for Environmental and Health Sciences, Kita 12, Nishi 7, Kita-ku, Sapporo 060-0812, Japan.
authors: Shi
authors: S
authors: Cong
authors: Hokkaido University Center for Environmental and Health Sciences, Kita 12, Nishi 7, Kita-ku, Sapporo 060-0812, Japan. Electronic address: rkishi@med.hokudai.ac.jp.
authors: Reiko
authors: R
authors: Kishi
mesh_terms: D002648:Child; D003876:Dermatitis, Atopic / Q000453:epidemiology / Q000209:etiology*; D004051:Diethylhexyl Phthalate; D004391:Dust / Q000032:analysis; D004781:Environmental Exposure / Q000009:adverse effects* / Q000032:analysis; D004785:Environmental Pollutants / Q000009:adverse effects* / Q000032:analysis / Q000276:immunology; D005260:Female; D005430:Floors and Floorcoverings; D006795:Household Products; D006801:Humans; D006967:Hypersensitivity; D007564:Japan / Q000453:epidemiology; D008297:Male; D009666:Nose; D010290:Parents; D010795:Phthalic Acids / Q000276:immunology* / Q000652:urine; D010968:Plasticizers; D012130:Respiratory Hypersensitivity / Q000453:epidemiology / Q000209:etiology*; D012135:Respiratory Sounds
chemical_list: D004391:Dust; D004785:Environmental Pollutants; D010795:Phthalic Acids; D010968:Plasticizers; C575690:mono-isobutyl phthalate; C032279:phthalic acid; D004051:Diethylhexyl Phthalate; C027561:butylbenzyl phthalate
keywords: Allergy; Child; Daily intake; House dust; Phthalates; Urinary metabolites