title: Evaluation of Bone Regeneration on Polyhydroxyethyl-polymethyl Methacrylate Membrane in a Rabbit Calvarial Defect Model.
abstract: This study was conducted to evaluate the capacity of guiding bone regeneration of polyhydroxyethyl-polymethyl methacrylate (PHEMA-PMMA) membrane as a guided tissue regeneration membrane for bone defects. Two 8-mm diameter transosseous round defects were made at the parietal bone of 18 New Zealand White rabbits. Defects were covered with or without PHEMA-PMMA membrane. Radiological and histological evaluation revealed that the bone tissue over the defect was more regenerated with time in both groups. However, there was significantly more bone regeneration at 8 weeks in the experimental group than the control group (p<0.05). There was no sign of membrane degradation or tissue inflammation and no invasion of muscle and fibrous tissue into defects. PHEMA-PMMA is a potential material for guided tissue regeneration membrane as it induces no adverse tissue reaction and effectively supports selective bone regeneration.
authors: Department of Veterinary Surgery, College of Veterinary Medicine, Chungbuk National University, Cheongju, Republic of Korea.
authors: Somin
authors: S
authors: Kim
authors: Department of Veterinary Surgery, College of Veterinary Medicine, Chungbuk National University, Cheongju, Republic of Korea.
authors: Yawon
authors: Y
authors: Hwang
authors: Department of Veterinary Surgery, College of Veterinary Medicine, Chungbuk National University, Cheongju, Republic of Korea.
authors: Muhammad
authors: M
authors: Kashif
authors: TE-Bios Company, LTD, C&V Center, Cheongju, Republic of Korea.
authors: Dosun
authors: D
authors: Jeong
authors: Department of Veterinary Surgery, College of Veterinary Medicine, Chungbuk National University, Cheongju, Republic of Korea ghkim@cbu.ac.kr.
authors: Gonhyung
authors: G
authors: Kim
mesh_terms: D000818:Animals; D001861:Bone Regeneration; D018786:Bone Substitutes / Q000008:administration & dosage / Q000009:adverse effects; D004195:Disease Models, Animal; D048091:Guided Tissue Regeneration; D006801:Humans; D008567:Membranes, Artificial; D011102:Polyhydroxyethyl Methacrylate / Q000008:administration & dosage* / Q000009:adverse effects; D019904:Polymethyl Methacrylate / Q000008:administration & dosage* / Q000009:adverse effects; D011817:Rabbits; D012886:Skull / Q000187:drug effects* / Q000473:pathology; D014945:Wound Healing / Q000187:drug effects
chemical_list: D018786:Bone Substitutes; D008567:Membranes, Artificial; D011102:Polyhydroxyethyl Methacrylate; D019904:Polymethyl Methacrylate
keywords: Periodontal membrane; parietal bone; polyhydroxyethyl-polymethyl methacrylate; rabbit