title: The prognostic value of D-dimer levels in metastatic osteosarcoma patients treated with second-line chemotherapy.
abstract: We performed a retrospective analysis of 32 metastatic osteosarcoma cases to examine the prognostic value of the plasma D-dimer level. We assessed the D-dimer level before second-line chemotherapy (D1) and the D-dimer level after two cycles of second-line chemotherapy (D2). The change in D-dimer level (ΔD) was defined as D2 minus D1. The overall survival (OS) of patients with a high D1 was significantly shorter than those with a low D1 (median OS, 4.7 vs. 16.2 months, P=0.001). Similar results were observed for the D2 (median OS, 4.7 vs. 8.6 months, P=0.033). Multivariable analysis demonstrated that a high D1 (hazard ratio, 3.375; 95% confidence interval, 1.133-10.053; P=0.029) was an unfavorable independent prognostic factor. The mean D2 of 11 patients with stable disease decreased by 0.69 mg/mL compared to the D1 (P = 0.016). The mean D2 increased by 1.47 mg/mL compared to the D1 in 21 patients with progressive disease (P = 0.004). The data suggest that D-dimer may serve as a prognostic biomarker for metastatic osteosarcoma patients treated with second-line chemotherapy.
authors: Department of Oncology, Affiliated Sixth People's Hospital, Shanghai Jiaotong University, 200233 Shanghai, People's Republic of China.
authors: Yujing
authors: Y
authors: Huang
authors: Department of Neurology, Affiliated Sixth People's Hospital, Shanghai Jiaotong University, 200233 Shanghai, People's Republic of China.
authors: Bangjian
authors: B
authors: Liu
authors: Department of Oncology, Affiliated Sixth People's Hospital, Shanghai Jiaotong University, 200233 Shanghai, People's Republic of China.
authors: Yuanjue
authors: Y
authors: Sun
authors: Department of Oncology, Affiliated Sixth People's Hospital, Shanghai Jiaotong University, 200233 Shanghai, People's Republic of China.
authors: Jianjun
authors: J
authors: Zhang
authors: Department of Oncology, Affiliated Sixth People's Hospital, Shanghai Jiaotong University, 200233 Shanghai, People's Republic of China.
authors: Yang
authors: Y
authors: Yao
authors: Department of Oncology, Affiliated Sixth People's Hospital, Shanghai Jiaotong University, 200233 Shanghai, People's Republic of China.
authors: Aina
authors: A
authors: He
mesh_terms: D000293:Adolescent; D054316:Biomarkers, Pharmacological / Q000378:metabolism*; D014408:Biomarkers, Tumor / Q000378:metabolism*; D001859:Bone Neoplasms / Q000175:diagnosis* / Q000188:drug therapy / Q000401:mortality; D005260:Female; D005338:Fibrin Fibrinogen Degradation Products / Q000378:metabolism*; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D009362:Neoplasm Metastasis; D012516:Osteosarcoma / Q000175:diagnosis* / Q000188:drug therapy / Q000401:mortality; D011237:Predictive Value of Tests; D011379:Prognosis; D012189:Retrospective Studies; D016019:Survival Analysis
chemical_list: D054316:Biomarkers, Pharmacological; D014408:Biomarkers, Tumor; D005338:Fibrin Fibrinogen Degradation Products; C036309:fibrin fragment D
keywords: D-dimer; chemotherapy response; osteosarcoma; prognosis; second-line chemotherapy