title: Facile approach to prepare drug-loading film from hemicelluloses and chitosan.
abstract: This study introduces a facile and green route to fabricate film from bio-based polymers. The film has been prepared by the cross-linking reaction of quaternized hemicelluloses (QH) and chitosan (CHO) with epichlorohydrin (ECH) as crosslinker. It exhibits an excellently mechanical performance as a result of its high tensile strength (up to 37MPa). Importantly, the roughness of film was 2-5nm in the area of 400nm, and smooth surface with pores were presented on the film based on the results of scanning electron microscope (SEM) and atomic force microscope (AFM). Ciprofloxacin was utilized as a mode compound to investigate the loading behavior of the film, and the highest loading concentration was about 18%. The drug release was about 20% in film1 in comparison to only 15% in film3 within 48h. Furthermore, the results of a 293T cell viability assay indicated its good biocompatibility and non-toxicity.
authors: School of Forestry and Landscape Architecture, AnHui Agricultural University, Hefei 230036, China.
authors: Ying
authors: Y
authors: Guan
authors: Beijing Key Laboratory of Lignocellulosic Chemistry, Beijing Forestry University, Beijing 100083, China.
authors: Xian-Ming
authors: XM
authors: Qi
authors: Beijing Key Laboratory of Lignocellulosic Chemistry, Beijing Forestry University, Beijing 100083, China.
authors: Ge-Gu
authors: GG
authors: Chen
authors: Beijing Key Laboratory of Lignocellulosic Chemistry, Beijing Forestry University, Beijing 100083, China. Electronic address: fengpeng@bjfu.edu.cn.
authors: Feng
authors: F
authors: Peng
authors: Beijing Key Laboratory of Lignocellulosic Chemistry, Beijing Forestry University, Beijing 100083, China. Electronic address: rcsun3@bjfu.edu.cn.
authors: Run-Cang
authors: RC
authors: Sun
mesh_terms: D000900:Anti-Bacterial Agents / Q000008:administration & dosage* / Q000737:chemistry; D001458:Bandages; D048271:Chitosan / Q000737:chemistry*; D002939:Ciprofloxacin / Q000008:administration & dosage* / Q000737:chemistry; D003432:Cross-Linking Reagents / Q000737:chemistry; D016503:Drug Delivery Systems / Q000379:methods*; D065546:Drug Liberation; D004811:Epichlorohydrin / Q000737:chemistry; D011134:Polysaccharides / Q000737:chemistry*; D013718:Tensile Strength
chemical_list: D000900:Anti-Bacterial Agents; D003432:Cross-Linking Reagents; D011134:Polysaccharides; D004811:Epichlorohydrin; D002939:Ciprofloxacin; C007916:hemicellulose; D048271:Chitosan
keywords: Biocompatibility; Chitosan; Drug-loading; Film; Qurternized hemicelluloses