title: Comparing the Incidence of Falls/Fractures in Parkinson's Disease Patients in the US Population.
abstract: Patients with Parkinson's disease (PD) may experience falls and/or fractures as a result of disease symptoms. There are limited data available from long-term studies estimating the incidence of falls/fractures in patients with PD. The objective was to compare the incidence rate of falls/fractures in PD patients with non-PD patients in a US population. This was a retrospective study using a US-based claims database (Truven Health MarketScan®) that compared the incidence rate of falls/fractures in PD subjects with non-PD subjects. The study period included the 12 months prior to index date (defined as earliest PD diagnosis [International Classification of Diseases, Ninth Revision, Clinical Modification code 332.0]) and a postindex period to the end of data availability. Fractures were defined by inpatient/outpatient claims as a principal or secondary diagnosis and accompanying procedure codes during the postindex period. Incidence rates and 95% CIs for falls/fractures were calculated as the number of events per 10,000 person-years of follow-up using negative binomial or Poisson regression models. Twenty-eight thousand two hundred and eighty PD subjects were matched to non-PD subjects for the analysis (mean [SD] age, 71.4 [11.8] years; 53% male). A higher incidence rate (adjusted for comorbidities and medications) of all fall/fracture cases and by fall and fracture types was observed for PD subjects versus non-PD subjects; the overall adjusted incidence rate ratio comparing PD to non-PD subjects was 2.05; 95% CI, 1.88-2.24. The incidence rate of falls/fractures was significantly higher in subjects with PD compared with non-PD subjects in a US population.
authors: UCB Pharma, Raleigh, North Carolina, United States of America.
authors: Linda
authors: L
authors: Kalilani
authors: UCB Pharma, Raleigh, North Carolina, United States of America.
authors: Mahnaz
authors: M
authors: Asgharnejad
authors: UCB Pharma, Monheim, Germany.
authors: Tuire
authors: T
authors: Palokangas
authors: UCB Pharma, Atlanta, Georgia, United States of America.
authors: Tracy
authors: T
authors: Durgin
mesh_terms: D000058:Accidental Falls / Q000706:statistics & numerical data*; D000328:Adult; D017677:Age Distribution; D000368:Aged; D005260:Female; D050723:Fractures, Bone / Q000150:complications* / Q000453:epidemiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000150:complications*; D012189:Retrospective Studies; D017678:Sex Distribution; D014481:United States / Q000453:epidemiology