title: [Variations of peripheral blood autoantibody, immunoglobuliln, and complement levels in patients with non-lactational mastitis and their clinical significances].
abstract: OBJECTIVE
  To detect the variations in peripheral blood levels of autoantibodies, immunoglobulilns and complements in patients with non-lactational mastitis and investigate whether non-lactational mastitis is an autoimmune disease with immune dysfunction.
  
  
  METHODS
  Seven-eight patients with non-lactational mastitis treated in our hospital between September 2013 and May 2015 and 88 healthy women (control) were examined for peripheral blood levels of antinuclear antibody (ANA), anti-histone antibody (AHA), immunoglobulins (IgA, IgM, and IgG) and complements (C3, C4, and total complements).
  
  
  RESULTS
  s Of the 78 patients with non-lactational mastitis, 50 (64.10%) were positive of ANA showing mainly the granular and cytoplasmic granular fluorescence patterns, and the positivity rate was significantly higher than that in the control group (P<0.000). Twenty-eight (36.00%) of the patients were positive of AHA, a rate significantly higher than that in the control group (P<0.000). The levels of IgA, IgM, C4, and total complements levels were all significantly elevated in the patients compared with those in the control group (P<0.05).
  
  
  CONCLUSIONS
  Patients with non-lactational mastitis have abnormal changes in peripheral blood levels of immunoglobulins and complements with high positivity rates for ANA and AHA, indicating that non-lactational mastitis is an autoimmune disease with immune dysfunction.
authors: Department of Mammary Disease, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou 510120, China. E-mail: catdoctor007@163.com.
authors: Rui
authors: R
authors: Xu
authors: Qian-Qian
authors: QQ
authors: Guo
authors: Le-Ping
authors: LP
authors: Yang
authors: Mi-Lin
authors: ML
authors: Lai
authors: Lin
authors: L
authors: Tong
mesh_terms: D000974:Antibodies, Antinuclear / Q000097:blood*; D001323:Autoantibodies / Q000097:blood*; D001327:Autoimmune Diseases / Q000097:blood* / Q000175:diagnosis; D016022:Case-Control Studies; D003165:Complement System Proteins / Q000032:analysis*; D005260:Female; D006801:Humans; D008413:Mastitis / Q000097:blood* / Q000175:diagnosis
chemical_list: D000974:Antibodies, Antinuclear; D001323:Autoantibodies; D003165:Complement System Proteins