title: Utility of Diffusion-Weighted MRI to Detect Changes in Liver Diffusion in Benign and Malignant Distal Bile Duct Obstruction: The Influence of Choice of b-Values.
abstract: OBJECTIVE
  The study sought to evaluate the potential of diffusion-weighted magnetic resonance imaging to detect changes in liver diffusion in benign and malignant distal bile duct obstruction and to investigate the effect of the choice of b-values on apparent diffusion coefficient (ADC).
  
  
  METHODS
  Diffusion-weighted imaging was acquired with b-values of 200, 600, 800, and 1000 s/mm2. ADC values were obtained in 4 segments of the liver. The mean ADC values of 16 patients with malignant distal bile duct obstruction, 14 patients with benign distal bile duct obstruction, and a control group of 16 healthy patients were compared.
  
  
  RESULTS
  Mean ADC values for 4 liver segments were lower in the malignant obstruction group than in the benign obstruction and control groups using b = 200 s/mm2(P < .05). Mean ADC values of the left lobe medial and lateral segments were lower in the malignant obstruction group than in the benign obstructive and control groups using b = 600 s/mm2(P < .05). Mean ADC values of the right lobe posterior segment were lower in the malignant and benign obstruction groups than in the control group using b = 1000 s/mm2(P < .05). Using b = 800 s/mm2, ADC values of all 4 liver segments in each group were not significantly different (P > .05). There were no correlations between the ADC values of liver segments and liver function tests.
  
  
  CONCLUSIONS
  Measurement of ADC shows good potential for detecting changes in liver diffusion in patients with distal bile duct obstruction. Calculated ADC values were affected by the choice of b-values.
authors: Department of Radiology, Baskent University School of Medicine, Adana, Turkey; Department of Radiology, Medipol University School of Medicine, Istanbul, Turkey. Electronic address: belgink8@yahoo.com.
authors: Belgin
authors: B
authors: Karan
authors: Department of Radiology, Baskent University School of Medicine, Adana, Turkey.
authors: Gurcan
authors: G
authors: Erbay
authors: Department of Radiology, Baskent University School of Medicine, Adana, Turkey.
authors: Zafer
authors: Z
authors: Koc
authors: Department of Radiology, Baskent University School of Medicine, Adana, Turkey.
authors: Aysin
authors: A
authors: Pourbagher
authors: Department of General Surgery, Baskent University School of Medicine, Ankara, Turkey.
authors: Sedat
authors: S
authors: Yildirim
authors: Department of Radiology, Baskent University School of Medicine, Adana, Turkey.
authors: Ahmet Muhtesem
authors: AM
authors: Agildere
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002277:Carcinoma / Q000150:complications / Q000000981:diagnostic imaging*; D002769:Cholelithiasis / Q000150:complications / Q000000981:diagnostic imaging; D002780:Cholestasis, Intrahepatic / Q000000981:diagnostic imaging* / Q000209:etiology*; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods; D004067:Digestive System Neoplasms / Q000150:complications / Q000000981:diagnostic imaging* / Q000473:pathology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010195:Pancreatitis / Q000150:complications / Q000000981:diagnostic imaging; D012189:Retrospective Studies
keywords: Biliary obstruction; Diffusion-weighted imaging; Liver fibrosis; Magnetic resonance imaging; b-value