title: Vaccine-related autoimmune hepatitis: the same disease as idiopathic autoimmune hepatitis? Two clinical reports and review.
abstract: Autoimmune hepatitis (AIH) develops in genetically predisposed individuals after an inciting or environmental trigger. These factors are unknown but may include viral infections, environmental toxins, drugs and vaccinations. Few reports are written about vaccination as potential trigger of autoimmune hepatitis. In this article, we additionally describe two vaccine-related cases of AIH. In both cases, long-term immune-suppressive therapy is demanded. Moreover, we present the cases of vaccine-related AIH from literature and compare these with idiopathic AIH and our own cases.
authors: a Department of Internal Medicine and Gastroenterology , Amphia Ziekenhuis Locatie Molengracht , Breda , the Netherlands.
authors: Marline A J
authors: MA
authors: van Gemeren
authors: a Department of Internal Medicine and Gastroenterology , Amphia Ziekenhuis Locatie Molengracht , Breda , the Netherlands.
authors: Peter
authors: P
authors: van Wijngaarden
authors: b Department of Pathology , Erasmus University Medical Centre Rotterdam , Rotterdam , the Netherlands.
authors: Michael
authors: M
authors: Doukas
authors: c Department of Gastroenterology and Hepatology , Erasmus University Medical Centre, Rotterdam , Rotterdam , the Netherlands.
authors: Robert A
authors: RA
authors: de Man
mesh_terms: D000328:Adult; D001323:Autoantibodies / Q000097:blood; D001652:Bile Ducts / Q000473:pathology; D005260:Female; D006506:Hepatitis A / Q000517:prevention & control; D022362:Hepatitis A Vaccines / Q000008:administration & dosage / Q000009:adverse effects*; D019693:Hepatitis, Autoimmune / Q000175:diagnosis* / Q000188:drug therapy / Q000209:etiology*; D006801:Humans; D007114:Immunization / Q000009:adverse effects*; D007165:Immunosuppression Therapy / Q000379:methods; D008099:Liver / Q000276:immunology / Q000473:pathology / Q000821:virology; D011241:Prednisone / Q000627:therapeutic use; D055815:Young Adult
chemical_list: D001323:Autoantibodies; D022362:Hepatitis A Vaccines; D011241:Prednisone
keywords: Hepatitis A virus; autoimmune hepatitis; autoimmunity; vaccination