title: The evaluation of sleep quality and response to anti-tumor necrosis factor α therapy in rheumatoid arthritis patients.
abstract: Poor sleep quality (SQ) is increasingly recognized as giving rise to decreased quality of life, and raising pain perception. Our aim is to evaluate the SQ in rheumatoid arthritis (RA) patients treated with anti-tumor necrosis factor alpha (anti-TNF-α) therapy. This was a prospective observational and open-label study of RA patients. A total of 35 patients with RA were enrolled in this study. Of the 35 patients, 22 had high disease activity (DA), and 13 were in remission. High DA group was initiated an anti TNF-α therapy. Clinical and objective parameters of SQ were assessed by using the Pittsburgh Sleep Quality Index (PSQI) and polysomnography (PSG). The total PSQI score and the frequency of poor SQ were high in 60 % of the RA patients. The median PSQI score was significantly higher in the high DA group than in the remission group (P = 0.026). Following an anti-TNF-α therapy initiation, significant improvements were observed in the high DA group by PSQI test (P = 0.012). However, no statistically significant difference was found by PSG (P > 0.05). Although an improvement in DA with anti-TNF-alpha therapy did not provide an amelioration in laboratory parameters, we found a significant improvement in SQ by subjective PSQI test. These findings may support that sleep disorders in RA are likely to be associated with a complex pathophysiology.
authors: Department of Physical Medicine, Ankara Physical Medicine and Rehabilitation Education and Research Hospital, 06100, Altindag, Ankara, Turkey. gulsah2206@gmail.com.
authors: Gulsah
authors: G
authors: Karatas
authors: Department of Physical Medicine and Rehabilitation, Diskapi Yildirim Beyazit Training and Research Hospital, Ankara, Turkey.
authors: Ajda
authors: A
authors: Bal
authors: Department of Respiratory and Sleep Medicine, Diskapi Yildirim Beyazit Training and Research Hospital, Ankara, Turkey.
authors: Melike
authors: M
authors: Yuceege
authors: Department of Physical Medicine, Ankara Physical Medicine and Rehabilitation Education and Research Hospital, 06100, Altindag, Ankara, Turkey.
authors: Elif
authors: E
authors: Yalcin
authors: Department of Respiratory and Sleep Medicine, Diskapi Yildirim Beyazit Training and Research Hospital, Ankara, Turkey.
authors: Hikmet
authors: H
authors: Firat
authors: Department of Physical Medicine and Rehabilitation, Diskapi Yildirim Beyazit Training and Research Hospital, Ankara, Turkey.
authors: Deniz
authors: D
authors: Dulgeroglu
authors: Department of Internal Medicine and Medical Oncology, Diskapi Yildirim Beyazit Training and Research Hospital, Ankara, Turkey.
authors: Fatih
authors: F
authors: Karataş
authors: Department of Internal Medicine and Medical Oncology, Diskapi Yildirim Beyazit Training and Research Hospital, Ankara, Turkey.
authors: Suleyman
authors: S
authors: Sahin
authors: Department of Physical Medicine and Rehabilitation, Diskapi Yildirim Beyazit Training and Research Hospital, Ankara, Turkey.
authors: Aytul
authors: A
authors: Cakci
authors: Department of Respiratory and Sleep Medicine, Diskapi Yildirim Beyazit Training and Research Hospital, Ankara, Turkey.
authors: Sadik
authors: S
authors: Ardic
mesh_terms: D000328:Adult; D000368:Aged; D018501:Antirheumatic Agents / Q000009:adverse effects / Q000627:therapeutic use*; D001172:Arthritis, Rheumatoid / Q000150:complications / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D017286:Polysomnography; D011446:Prospective Studies; D011788:Quality of Life; D012074:Remission Induction; D012720:Severity of Illness Index; D012890:Sleep; D012893:Sleep Wake Disorders / Q000150:complications*; D016896:Treatment Outcome; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors*
chemical_list: D018501:Antirheumatic Agents; C439524:TNF protein, human; D014409:Tumor Necrosis Factor-alpha
keywords: Anti TNF-α therapy; Disease activity; Polysomnography; Rheumatoid arthritis; Sleep quality