title: Effect of decision aid for breast cancer prevention on decisional conflict in women with a BRCA1 or BRCA2 mutation: a multisite, randomized, controlled trial.
abstract: Women with a BRCA1 or BRCA2 mutation are at high risk for breast cancer and must make important decisions about breast cancer prevention and screening. In the current study, we report a multisite, randomized, controlled trial evaluating the effectiveness of a decision aid for breast cancer prevention in women with a BRCA mutation with no previous diagnosis of cancer.
  
  
  
  Within 1 month of receiving a positive BRCA result, women were randomized to receive either usual care (control group) or decision aid (intervention group). Participants were followed at 3, 6, and 12 months; were asked about preventive measures; and completed standardized questionnaires assessing decision making and psychosocial functioning.
  
  
  
  One hundred fifty women were randomized. Mean cancer-related distress scores were significantly lower in the intervention group compared with the control group at 6 months (P = 0.01) and at 12 months postrandomization (P = 0.05). Decisional conflict scores declined over time for both groups and at no time were there statistical differences between the two groups.
  
  
  
  The decision aid for breast cancer prevention in women with a BRCA1 or BRCA2 mutation is effective in significantly decreasing cancer-related distress within the year following receipt of positive genetic test results.Genet Med 19 3, 330-336.
authors: Women's College Research Institute, Toronto, Ontario, Canada.|Lawrence S. Bloomberg Faculty of Nursing, University of Toronto, Toronto, Ontario, Canada.
authors: Kelly A
authors: KA
authors: Metcalfe
authors: Women's College Research Institute, Toronto, Ontario, Canada.|Lawrence S. Bloomberg Faculty of Nursing, University of Toronto, Toronto, Ontario, Canada.
authors: Cindy-Lee
authors: CL
authors: Dennis
authors: Women's College Research Institute, Toronto, Ontario, Canada.
authors: Aletta
authors: 0000-0003-4891-4947
authors: A
authors: Poll
authors: University Health Network, Toronto, Ontario, Canada.
authors: Susan
authors: 0000-0001-5016-3148
authors: S
authors: Armel
authors: University Health Network, Toronto, Ontario, Canada.
authors: Rochelle
authors: R
authors: Demsky
authors: Lawrence S. Bloomberg Faculty of Nursing, University of Toronto, Toronto, Ontario, Canada.
authors: Lindsay
authors: 0000-0002-0767-0029
authors: L
authors: Carlsson
authors: Women's College Research Institute, Toronto, Ontario, Canada.
authors: Sonia
authors: 0000-0002-3140-1590
authors: S
authors: Nanda
authors: Sunnybrook Research Institute, Toronto, Ontario, Canada.
authors: Alexander
authors: A
authors: Kiss
authors: Women's College Research Institute, Toronto, Ontario, Canada.
authors: Steven A
authors: SA
authors: Narod
mesh_terms: D000328:Adult; D019313:BRCA1 Protein / Q000235:genetics; D001943:Breast Neoplasms / Q000235:genetics / Q000517:prevention & control* / Q000523:psychology; D003657:Decision Making / Q000941:ethics; D003661:Decision Support Techniques; D005260:Female; D019398:Genes, BRCA1; D024522:Genes, BRCA2; D005817:Genetic Counseling / Q000523:psychology; D005820:Genetic Testing; D006801:Humans; D008875:Middle Aged; D012307:Risk Factors; D011795:Surveys and Questionnaires
chemical_list: D019313:BRCA1 Protein; C492913:BRCA1 protein, human