title: The CXCL8-CXCR1/2 pathways in cancer.
abstract: Persistent infection or chronic inflammation contributes significantly to tumourigenesis and tumour progression. C-X-C motif ligand 8 (CXCL8) is a chemokine that acts as an important multifunctional cytokine to modulate tumour proliferation, invasion and migration in an autocrine or paracrine manner. Studies have suggested that CXCL8 and its cognate receptors, C-X-C chemokine receptor 1 (CXCR1) and C-X-C chemokine receptor 2 (CXCR2), mediate the initiation and development of various cancers including breast cancer, prostate cancer, lung cancer, colorectal carcinoma and melanoma. CXCL8 also integrates with multiple intracellular signalling pathways to produce coordinated effects. Neovascularisation, which provides a basis for fostering tumour growth and metastasis, is now recognised as a critical function of CXCL8 in the tumour microenvironment. In this review, we summarize the biological functions and clinical significance of the CXCL8 signalling axis in cancer. We also propose that CXCL8 may be a potential therapeutic target for cancer treatment.
authors: Department of Oncology, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
authors: Qian
authors: Q
authors: Liu
authors: Department of Interventional Radiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China.
authors: Anping
authors: A
authors: Li
authors: Department of Oncology, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
authors: Yijun
authors: Y
authors: Tian
authors: Department of Microbiology and Immunology, Hollings Cancer Center, Medical University of South Carolina, Charleston, SC, USA.
authors: Jennifer D
authors: JD
authors: Wu
authors: Department of Geriatric, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
authors: Yu
authors: Y
authors: Liu
authors: Department of Interventional Radiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China.
authors: Tengfei
authors: T
authors: Li
authors: Department of Oncology, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
authors: Yuan
authors: Y
authors: Chen
authors: Department of Interventional Radiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China. Electronic address: hanxinwei2006@163.com.
authors: Xinwei
authors: X
authors: Han
authors: Department of Oncology, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China. Electronic address: kmwu@tjh.tjmu.edu.cn.
authors: Kongming
authors: K
authors: Wu
mesh_terms: D000818:Animals; D006801:Humans; D016209:Interleukin-8 / Q000737:chemistry / Q000378:metabolism*; D058990:Molecular Targeted Therapy; D009369:Neoplasms / Q000378:metabolism*; D011487:Protein Conformation; D023062:Receptors, Interleukin-8A / Q000737:chemistry / Q000378:metabolism*; D023063:Receptors, Interleukin-8B / Q000737:chemistry / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D016209:Interleukin-8; D023062:Receptors, Interleukin-8A; D023063:Receptors, Interleukin-8B
keywords: Angiogenesis; CXCL8; CXCR1; CXCR2; Cancer; Metastasis