title: The BCR-ABL/NF-κB signal transduction network: a long lasting relationship in Philadelphia positive Leukemias.
abstract: The Nuclear Factor-kappa B (NF-κB) family of transcription factors plays a key role in cancer pathogenesis due to the ability to promote cellular proliferation and survival, to induce resistance to chemotherapy and to mediate invasion and metastasis. NF-κB is recruited through different mechanisms involving either canonical (RelA/p50) or non-canonical pathways (RelB/p50 or RelB/p52), which transduce the signals originated from growth-factors, cytokines, oncogenic stress and DNA damage, bacterial and viral products or other stimuli. The pharmacological inhibition of the NF-κB pathway has clearly been associated with significant clinical activity in different cancers. Almost 20 years ago, NF-κB was described as an essential modulator of BCR-ABL signaling in Chronic Myeloid Leukemia and Philadelphia-positive Acute Lymphoblastic Leukemia. This review summarizes the role of NF-κB in BCR-ABL-mediated leukemogenesis and provides new insights on the long lasting BCR-ABL/NF-κB connection.
authors: Department of Clinical and Biological Sciences, University of Turin, Orbassano, Italy.
authors: Giovanna
authors: G
authors: Carrà
authors: Department of Clinical and Biological Sciences, University of Turin, Orbassano, Italy.
authors: Davide
authors: D
authors: Torti
authors: Department of Clinical and Biological Sciences, University of Turin, Orbassano, Italy.
authors: Sabrina
authors: S
authors: Crivellaro
authors: Department of Clinical and Biological Sciences, University of Turin, Orbassano, Italy.
authors: Cristina
authors: C
authors: Panuzzo
authors: Department of Oncology, University of Turin, Orbassano, Italy.
authors: Riccardo
authors: R
authors: Taulli
authors: Department of Clinical and Biological Sciences, University of Turin, Orbassano, Italy.
authors: Daniela
authors: D
authors: Cilloni
authors: Department of Clinical and Biological Sciences, University of Turin, Orbassano, Italy.
authors: Angelo
authors: A
authors: Guerrasio
authors: Department of Clinical and Biological Sciences, University of Turin, Orbassano, Italy.
authors: Giuseppe
authors: G
authors: Saglio
authors: Department of Clinical and Biological Sciences, University of Turin, Orbassano, Italy.
authors: Alessandro
authors: A
authors: Morotti
mesh_terms: D017209:Apoptosis; D049109:Cell Proliferation; D016044:Fusion Proteins, bcr-abl / Q000378:metabolism*; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000378:metabolism / Q000473:pathology*; D016328:NF-kappa B / Q000378:metabolism*; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000378:metabolism / Q000473:pathology*; D015398:Signal Transduction
chemical_list: D016328:NF-kappa B; D016044:Fusion Proteins, bcr-abl
keywords: BCR-ABL; CML; IκB-α; NF-κB; NFKBIA