title: Renal Dysfunction in Post-Stroke Patients.
abstract: BACKGROUND
  The presence of chronic kidney disease (CKD) is an indicator of a worse long-term prognosis in patients with ischemic stroke (IS). Unfortunately, not much is known about renal function in the population of post-IS subjects. The aim of our study was to assess the prevalence of renal damage and impaired renal function (IRF) in the population of post-IS subjects.
  
  
  METHODS
  This prospective analysis concerned 352 consecutive post-IS survivors hospitalized in Pomeranian stroke centers (Poland) in 2009. In this group estimated glomerular filtration rate (eGFR) according to MDRD (modification of diet in renal diseases) and CKD-EPI (Chronic Kidney Disease Epidemiology Collaboration) formulas and urine albumin/creatinine ratio (ACR) were determined.
  
  
  RESULTS
  Among survivors decreased eGFR (<60 mL/min./1.73m2 according to MDRD or CKD-EPI) or ACR≥30mg/g were detected in 40.38% (23.07% Men, 55.32% Women; P<0.01). The highest prevalence of IRF was noted in post-IS subjects with atheromatic and lacunar IS. In multivariate analysis the ACR≥30mg/g was predicted by older age, diabetes mellitus (DM) and physical disability (modified Rankin scale 3-5 pts.). The association with reduced eGFR was proved for sex (female), DM and physical disability.
  
  
  CONCLUSIONS
  CKD is a frequently occurring problem in the group of post-IS subjects, especially after lacunar and atheromatic IS. Post-IS patients, mainly the elderly women, with physical disability and diabetes mellitus, should be regularly screened for CKD. This could reduce the risk of further cardiovascular events and delay the progression of IRF.
authors: Department of Neurology, Medical University of Gdańsk, Gdańsk, Poland.
authors: Kamil
authors: http://orcid.org/0000-0002-1361-8796
authors: K
authors: Chwojnicki
authors: Department of Nephrology, Medical University of Gdańsk, Gdańsk, Poland.
authors: Ewa
authors: E
authors: Król
authors: Department of Arterial Hypertension and Diabetology, Medical University of Gdańsk, Gdańsk, Poland.
authors: Łukasz
authors: Ł
authors: Wierucki
authors: Department of Neurology, Medical University of Gdańsk, Gdańsk, Poland.
authors: Grzegorz
authors: G
authors: Kozera
authors: Department of Neurology and Stroke Unit, Hospital of Sandomierz, Sandomierz, Poland.
authors: Piotr
authors: P
authors: Sobolewski
authors: Department of Neurology, Medical University of Gdańsk, Gdańsk, Poland.
authors: Walenty M
authors: WM
authors: Nyka
authors: Department of Arterial Hypertension and Diabetology, Medical University of Gdańsk, Gdańsk, Poland.
authors: Tomasz
authors: T
authors: Zdrojewski
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000418:Albumins / Q000378:metabolism*; D003404:Creatinine / Q000097:blood*; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D007668:Kidney / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D011044:Poland / Q000453:epidemiology; D015995:Prevalence; D011446:Prospective Studies; D051436:Renal Insufficiency, Chronic / Q000453:epidemiology* / Q000378:metabolism / Q000503:physiopathology; D012307:Risk Factors; D020521:Stroke / Q000150:complications* / Q000378:metabolism; D016019:Survival Analysis
chemical_list: D000418:Albumins; D003404:Creatinine