title: Macrocephaly Is Not a Predictor of Optic Pathway Glioma Development or Treatment in Neurofibromatosis Type 1.
abstract: Neurofibromatosis type 1 is a common neurogenetic disorder characterized by significant clinical variability. As such, numerous studies have focused on identifying clinical, radiographic, or molecular biomarkers that predict the occurrence or progression of specific clinical features in individuals with neurofibromatosis type 1. One of these clinical biomarkers, macrocephaly, has been proposed as a prognostic factor for optic pathway glioma development. In the current study, the authors demonstrate that macrocephaly is not associated with the development of these brain tumors or the need to institute treatment for clinical progression. These findings suggest that macrocephaly is not a robust biomarker of optic pathway glioma formation or progression in children with neurofibromatosis type 1.
authors: Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA.
authors: Stephanie M
authors: SM
authors: Morris
authors: Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA.
authors: Courtney L
authors: CL
authors: Monroe
authors: Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA gutmannd@wustl.edu.
authors: David H
authors: DH
authors: Gutmann
mesh_terms: D000293:Adolescent; D002648:Child; D015331:Cohort Studies; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008297:Male; D058627:Megalencephaly / Q000150:complications* / Q000175:diagnosis* / Q000628:therapy; D009456:Neurofibromatosis 1 / Q000150:complications* / Q000175:diagnosis* / Q000628:therapy; D020339:Optic Nerve Glioma / Q000150:complications* / Q000175:diagnosis* / Q000628:therapy; D011379:Prognosis; D012189:Retrospective Studies; D055815:Young Adult
keywords: brain tumor; head circumference; heterogeneity; neurofibromatosis type 1; occipital-frontal circumference