title: [Virulence of Sporothrix globosa in murine models].
abstract: BACKGROUND
  The sporothricosis disease is an infection caused by species included in Sporothrix schenkii complex.
  
  
  OBJECTIVE
  Verify the virulence of a strain of S. globosa using two different concentrations of inoculum by intraperitoneally and subcutaneously, into a mouse model.
  
  
  METHODS
  Nonrandomized pilot study, in murine inoculated with a strain of S. globosa (CBS 14.076M) by intraperitoneally and subcutaneously with inoculum concentrations of 0.5 and 4 McFarland. For this purpose 18 rodents CF-1 (ISP, Santiago, Chile) were used.
  
  
  RESULTS
  The studied strain did not induce illness or injury on animals, they all survived and neither the tissue culture nor the histopathological analysis showed fungal growth or suggestive infection by organ abnormalities.
  
  
  CONCLUSIONS
  The S. globosa strain did not present any virulence enough to cause disease at 0.5 and 4.0 McFarland concentration inoculum when inoculated in both intraperitoneally and subcutaneously, in murine models.
authors: Cátedra de Micología, Universidad de Valparaíso, Unidad de Infectología, Hospital Carlos van Buren, Valparaíso, Chile. Electronic address: rcruzchoappa@gmail.com.
authors: Rodrigo
authors: R
authors: Cruz Choappa
authors: Escuela de Medicina, Universidad de Valparaíso, Chile.
authors: Salomón
authors: S
authors: Pérez Gaete
authors: Escuela de Medicina, Universidad de Valparaíso, Chile.
authors: Valentina
authors: V
authors: Rodríguez Badilla
authors: Cátedra de Micología y Anatomía Patológica, Universidad de Valparaíso, Valparaíso, Chile.
authors: Peggy
authors: P
authors: Vieille Oyarzo
authors: Anatomía Patológica, Universidad de Valparaíso, Chile.
authors: Héctor
authors: H
authors: Opazo Sanchez
mesh_terms: D000818:Animals; D004198:Disease Susceptibility; D007274:Injections, Intraperitoneal; D007279:Injections, Subcutaneous; D051379:Mice / Q000382:microbiology*; D023421:Models, Animal; D013045:Species Specificity; D013172:Spores, Fungal / Q000472:pathogenicity; D013175:Sporothrix / Q000302:isolation & purification / Q000472:pathogenicity*; D013174:Sporotrichosis / Q000382:microbiology*; D013535:Suspensions; D014774:Virulence
chemical_list: D013535:Suspensions
keywords: Esporotricosis; Pathogenicity; Patogenicidad; Sporothrix globosa; Sporotrichosis