title: Dealing with Gene-Dosage Imbalance during S Phase.
abstract: DNA replication perturbs the dosage balance between genes that replicate early during S phase and those that replicate late. If propagated to influence protein content, this dosage imbalance could influence cellular functions. In bacteria, mechanisms have evolved to use this imbalance to tune certain processes with the rate of cell growth. By contrast, eukaryotes buffer this dosage imbalance to ensure gene expression homeostasis also during S phase. Here, we outline classical and more recent studies describing how different organisms deal with this replication-dependent dosage imbalance, and describe recent results linking the eukaryotic buffering mechanism to replication-dependent histone acetylation. Finally, we discuss the possible implications of this buffering mechanism and speculate why it is specific to eukaryote cells.
authors: Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 76100, Israel.
authors: Raz
authors: R
authors: Bar-Ziv
authors: Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 76100, Israel.
authors: Yoav
authors: Y
authors: Voichek
authors: Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 76100, Israel. Electronic address: naama.barkai@weizmann.ac.il.
authors: Naama
authors: N
authors: Barkai
mesh_terms: D000107:Acetylation; D001419:Bacteria / Q000235:genetics; D002453:Cell Cycle / Q000235:genetics; D004261:DNA Replication / Q000235:genetics*; D056890:Eukaryota / Q000235:genetics; D018628:Gene Dosage / Q000235:genetics*; D006657:Histones / Q000235:genetics; D016196:S Phase / Q000235:genetics*; D014158:Transcription, Genetic
chemical_list: D006657:Histones
keywords: gene dosage; replication; transcription