title: Clonal Evolution of Stem Cells in the Gastrointestinal Tract.
abstract: The field of gastrointestinal epithelial stem cells is a rapidly developing area of adult stem cell research. The discovery of Lgr5(+) intestinal stem cells has enabled us to study many hidden aspects of the biology of gastrointestinal adult stem cells. Marked by Lgr5 and Troy, several novel endodermal stem cells have been identified in the gastrointestinal tract. A precise working model of stem cell propagation, dynamics, and plasticity has been revealed by a genetic labeling method, termed lineage tracing. This chapter introduces the reidentification of crypt base columnar cells as Lgr5(+) stem cells in the intestine. Subsequently, it will discuss dynamic clonal evolution and cellular plasticity in the intestinal stem cell zone, as well as in stem cell zones of stomach glands.
authors: Department of Genetics, Wellcome Trust-Medical Research Council Stem Cell Institute, University of Cambridge, Cambridge, UK.
authors: Juergen
authors: J
authors: Fink
authors: Department of Genetics, Wellcome Trust-Medical Research Council Stem Cell Institute, University of Cambridge, Cambridge, UK. bkk25@cam.ac.uk.
authors: Bon-Kyoung
authors: BK
authors: Koo
mesh_terms: D053687:Adult Stem Cells / Q000166:cytology / Q000378:metabolism; D000818:Animals; D014408:Biomarkers, Tumor / Q000235:genetics; D019070:Cell Lineage / Q000235:genetics; D060965:Clonal Evolution; D004847:Epithelial Cells / Q000166:cytology / Q000378:metabolism; D041981:Gastrointestinal Tract / Q000166:cytology* / Q000378:metabolism; D006801:Humans; D007413:Intestinal Mucosa / Q000166:cytology* / Q000378:metabolism; D013234:Stem Cells / Q000166:cytology* / Q000378:metabolism
chemical_list: D014408:Biomarkers, Tumor
keywords: Cellular plasticity; Clonal evolution; Corpus Troy+ reserve stem cells; Intestinal Lgr5+ stem cells; Intestinal stem cell niche; Neutral competition; Pylorus Lgr5+ stem cells