title: Phleghenrines A-D and Neophleghenrine A, Bioactive and Structurally Rigid Lycopodium Alkaloids from Phlegmariurus henryi.
abstract: Five new Lycopodium alkaloids, phleghenrines A-D (1-4) and neophleghenrine A (5), were isolated from Phlegmariurus henryi (Baker) Ching. The structures and absolute configurations of 1-5 were determined using extensive spectroscopic data coupled with computational calculations and revealed 1-4 possess a bicyclo[3.2.2]nonane core, whereas 5 possesses an unprecedented 9-azaprotoadamantane core. Compounds 1 and 4 showed potent acetylcholinesterase (AChE) inhibitory activities, and 4 is a good lead natural product for the treatment of Alzheimer's disease.
authors: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences , Kunming 650201, People's Republic of China.|Department of Chemistry, The Scripps Research Institute , Jupiter, Florida 33458, United States.
authors: Liao-Bin
authors: LB
authors: Dong
authors: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences , Kunming 650201, People's Republic of China.
authors: Xing-De
authors: XD
authors: Wu
authors: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences , Kunming 650201, People's Republic of China.
authors: Xin
authors: X
authors: Shi
authors: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences , Kunming 650201, People's Republic of China.
authors: Zhi-Jun
authors: ZJ
authors: Zhang
authors: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences , Kunming 650201, People's Republic of China.
authors: Jing
authors: J
authors: Yang
authors: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences , Kunming 650201, People's Republic of China.
authors: Qin-Shi
authors: QS
authors: Zhao