title: TH9 cell differentiation, transcriptional control and function in inflammation, autoimmune diseases and cancer.
abstract: Naïve CD4+T cells differentiate into various T cell subsets depending on the specific cytokine environment. TH9 cells are less well-characterized than other T cell subsets, and factors that control their development and function have only recently been identified. It is now clear that TH9 cells play critical roles in immune-mediated diseases, including allergic airway, autoimmune and inflammatory bowel diseases, and cancer. Thus, the promotion or suppression of TH9 cell differentiation, transcriptional control and function may provide novel treatments for clinical inflammation, autoimmune diseases and tumors.
authors: Key Laboratory of Cell Proliferation and Regulation Biology of Ministry of Education, Institute of Cell Biology, College of Life Sciences, Beijing Normal University, Beijing, China.|Department of Immunology, School of Basic Medical Sciences, Fudan University, Shanghai, China.
authors: Yan
authors: Y
authors: Li
authors: Key Laboratory of Cell Proliferation and Regulation Biology of Ministry of Education, Institute of Cell Biology, College of Life Sciences, Beijing Normal University, Beijing, China.
authors: Qing
authors: Q
authors: Yu
authors: Key Laboratory of Cell Proliferation and Regulation Biology of Ministry of Education, Institute of Cell Biology, College of Life Sciences, Beijing Normal University, Beijing, China.|Department of Immunology, School of Basic Medical Sciences, Fudan University, Shanghai, China.
authors: Zhengguo
authors: Z
authors: Zhang
authors: Key Laboratory of Cell Proliferation and Regulation Biology of Ministry of Education, Institute of Cell Biology, College of Life Sciences, Beijing Normal University, Beijing, China.|Department of Immunology, School of Basic Medical Sciences, Fudan University, Shanghai, China.
authors: Jian
authors: J
authors: Wang
authors: Key Laboratory of Cell Proliferation and Regulation Biology of Ministry of Education, Institute of Cell Biology, College of Life Sciences, Beijing Normal University, Beijing, China.
authors: Simin
authors: S
authors: Li
authors: Key Laboratory of Cell Proliferation and Regulation Biology of Ministry of Education, Institute of Cell Biology, College of Life Sciences, Beijing Normal University, Beijing, China.
authors: Jiangyuan
authors: J
authors: Zhang
authors: Key Laboratory of Cell Proliferation and Regulation Biology of Ministry of Education, Institute of Cell Biology, College of Life Sciences, Beijing Normal University, Beijing, China.|Department of Immunology, School of Basic Medical Sciences, Fudan University, Shanghai, China.
authors: Guangwei
authors: G
authors: Liu
mesh_terms: D001327:Autoimmune Diseases / Q000276:immunology*; D002454:Cell Differentiation / Q000235:genetics / Q000276:immunology*; D016207:Cytokines / Q000235:genetics / Q000276:immunology / Q000378:metabolism; D003602:Cytotoxicity, Immunologic; D005786:Gene Expression Regulation; D006801:Humans; D007249:Inflammation / Q000276:immunology*; D009369:Neoplasms / Q000276:immunology*; D015398:Signal Transduction / Q000276:immunology; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology / Q000473:pathology*
chemical_list: D016207:Cytokines
keywords: T cell differentiation; TH9; allergic airway inflammation; autoimmune diseases; tumor