title: Clinical and electrophysiological findings in mesial temporal lobe epilepsy with hippocampal sclerosis, based on the recent histopathological classifications.
abstract: Hippocampal sclerosis (HS) is a common pathology in MTLE, patients may show different surgical outcomes and clinical features. The 2013 ILAE classification subdivides HS into 3 types (HS type 1: severe neuronal loss and gliosis predominantly in CA1 and CA4 regions; - HS type 2: CA1 predominant; HS type 3: CA4 predominant) and includes "gliosis only, as no-HS". The association of clinical and electrophysiological findings with different HS types has not been reported previously in detail.
  
  
  
  48 patients who had undergone temporal lobectomy with amygdalohippocampectomy due to mesial TLE-HS between February 2014 and February 2016 were included. The patients were divided into five groups: patients with HS ILAE type 1, HS ILAE type 2, HS ILAE type 3, FCD type IIIa, or gliosis/no HS. The correlation between HS ILAE types and clinical/EEG findings in patients with MTLE due to HS was investigated.
  
  
  
  Of the 48 patients 30 were male. In 23 patients, the resection was on the left side (48%). Three patients had only gliosis, 25 patients had HS ILAE type 1, 7 had HS ILAE type 2, and 4 had HS ILAE type 3. Nine of the 48 patients had cortical lamination abnormalities in the temporal lobe associated with HS (FCD type IIIa). All patients were seizure free for early follow up. There was no association between type of HS in terms of duration of epilepsy, onset age of epilepsy, lateralized or localized semiological findings, or interictal/ictal EEG findings. Family history of epilepsy or SGTCSs were statistically more frequent in patients with types 2 and 3 HS and status epilepticus was more frequent in patients with HS-FCD type IIIa.
  
  
  
  The patients with HS types 2 and 3 have more frequent SGTCS or status epilepticus as well as increased family history of epilepsy. These findings can be helpful in understanding the epileptogenicity-prognoses of HS.
authors: Hacettepe University, Faculty of Medicine, Dept. of Neurology, Ankara, Turkey. Electronic address: irseltezer@yahoo.com.tr.
authors: F Irsel
authors: FI
authors: Tezer
authors: Hacettepe University, Faculty of Medicine, Dept. of Neurology, Ankara, Turkey.
authors: Farid
authors: F
authors: Xasiyev
authors: Hacettepe University, Faculty of Medicine, Dept. of Pathology, Ankara, Turkey.
authors: Figen
authors: F
authors: Soylemezoglu
authors: Hacettepe University, Faculty of Medicine, Dept. of Neurosurgery, Ankara, Turkey.
authors: Burcak
authors: B
authors: Bilginer
authors: Hacettepe University, Faculty of Medicine, Dept. of Radiology, Ankara, Turkey.
authors: Kader Karli
authors: KK
authors: Oguz
authors: Hacettepe University, Faculty of Medicine, Dept. of Neurology, Ankara, Turkey.
authors: Serap
authors: S
authors: Saygi
mesh_terms: D000328:Adult; D038481:Anterior Temporal Lobectomy; D000069279:Drug Resistant Epilepsy / Q000145:classification / Q000473:pathology / Q000503:physiopathology* / Q000601:surgery; D004569:Electroencephalography; D004833:Epilepsy, Temporal Lobe / Q000145:classification / Q000473:pathology / Q000503:physiopathology* / Q000601:surgery; D005190:Family; D005260:Female; D005500:Follow-Up Studies; D020022:Genetic Predisposition to Disease; D006624:Hippocampus / Q000473:pathology / Q000503:physiopathology* / Q000601:surgery; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012598:Sclerosis / Q000145:classification / Q000473:pathology / Q000503:physiopathology / Q000601:surgery; D013226:Status Epilepticus / Q000145:classification / Q000473:pathology / Q000503:physiopathology / Q000601:surgery; D055815:Young Adult
keywords: Epilepsy; Hippocampal sclerosis; Pathology; Seizure; Temporal lobe epilepsy; Types of hippocampal sclerosis