title: Upper airway stimulation therapy: A novel approach to managing obstructive sleep apnea.
abstract: Review the role of upper airway stimulation (UAS) therapy in the management of moderate to severe obstructive sleep apnea (OSA).
  
  
  
  A literature search was performed of PubMed and Medline using the search terms clinical trial; obstructive sleep apnea; upper airway stimulation; hypoglossal stimulation; hypoglossal nerve; Inspire; and ImThera.
  
  
  
  All published clinical trials of currently available devices were reviewed. Unpublished data were excluded.
  
  
  
  UAS therapy results in surgical success (AHI decrease of >50% and overall AHI <= 20) in 66% of implanted subjects. In addition, UAS therapy results in significant improvement in daytime sleepiness, snoring, and sleep-related quality of life.
  
  
  
  UAS therapy is a valid alternative for select patients with moderate to severe OSA who are unsuccessful users of CPAP therapy. Laryngoscope, 126:S5-S8, 2016.
authors: Department of Otolaryngology-Head and Neck Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania, U.S.A.
authors: Ryan J
authors: RJ
authors: Soose
authors: Department of Otolaryngology-Head and Neck Surgery, Medical University of South Carolina, Charleston, South Carolina, U.S.A.
authors: M Boyd
authors: MB
authors: Gillespie
mesh_terms: D004599:Electric Stimulation Therapy; D005500:Follow-Up Studies; D005544:Forecasting; D006801:Humans; D020181:Sleep Apnea, Obstructive / Q000628:therapy*
keywords: Upper airway stimulation; obstructive sleep apnea; sleep medicine