title: New labdane diterpenoids from Croton laui and their anti-inflammatory activities.
abstract: Nine new labdane diterpenoids (1-9) were isolated from the aerial parts of Croton laui, along with eight known analogues (10-17). Their structures were identified on the basis of the spectral data (IR, UV, HRESIMS, 1D and 2D NMR), and the structure of 8 was confirmed by single crystal X-ray diffraction analyses. In addition, compounds 1, 4, 7, 8, and 14 showed weak anti-inflammatory activities in LPS-stimulated RAW 264.7 cells.
authors: Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, PR China.
authors: Li
authors: L
authors: Yang
authors: Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, PR China.
authors: Yu-Bo
authors: YB
authors: Zhang
authors: Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, PR China.
authors: Li-Feng
authors: LF
authors: Chen
authors: Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, PR China.
authors: Neng-Hua
authors: NH
authors: Chen
authors: Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, PR China.
authors: Zhong-Nan
authors: ZN
authors: Wu
authors: Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, PR China.
authors: Si-Qi
authors: SQ
authors: Jiang
authors: Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, PR China.
authors: Lin
authors: L
authors: Jiang
authors: Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, PR China.
authors: Guo-Qiang
authors: GQ
authors: Li
authors: Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, PR China. Electronic address: tliyl@jnu.edu.cn.
authors: Yao-Lan
authors: YL
authors: Li
authors: Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, PR China. Electronic address: twangguocai@jnu.edu.cn.
authors: Guo-Cai
authors: GC
authors: Wang
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D002460:Cell Line; D029802:Croton / Q000737:chemistry*; D004224:Diterpenes / Q000302:isolation & purification* / Q000494:pharmacology; D051379:Mice; D013057:Spectrum Analysis / Q000379:methods
chemical_list: D000893:Anti-Inflammatory Agents; D004224:Diterpenes
keywords: Anti-inflammatory activity; Croton laui; Labdane diterpenoid