title: DRESS Syndrome Caused by Cross-reactivity Between Vancomycin and Subsequent Teicoplanin Administration: A Case Report.
abstract: BACKGROUND Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome is a potentially life-threatening syndrome comprising severe skin eruption, fever, eosinophilia, lymphadenopathy, and involvement of internal organs. Here, we describe a case of DRESS syndrome caused by cross-reactivity between vancomycin and subsequent teicoplanin administration. CASE REPORT A 79-year-old male was admitted to our hospital for the treatment of injuries incurred in a traffic accident. Eosinophilia and lung dysfunction appeared after vancomycin administration. These symptoms were improved temporarily by withdrawal of vancomycin and administration of corticosteroid, but exacerbated by subsequent teicoplanin administration. These symptoms disappeared after discontinuation of teicoplanin. Based on comprehensive assessment of the overall clinical course, we judged that DRESS syndrome was induced by cross-reactivity between vancomycin and subsequent teicoplanin administration. Using the European Registry of Severe Cutaneous Adverse Reactions (RegiSCAR) scoring system, we categorized DRESS syndrome related to vancomycin and teicoplanin as "probable." We describe, for the first time, DRESS syndrome (defined using the RegiSCAR scoring system) caused by cross-reactivity between vancomycin and subsequent teicoplanin administration. CONCLUSIONS Clinicians should be aware that DRESS syndrome can be induced by cross-reactivity between vancomycin and teicoplanin.
authors: Department of Pharmaceutical Care and Health Sciences, Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka, Japan.
authors: Daisuke
authors: D
authors: Miyazu
authors: Department of Internal Medicine, Fukuoka Tokushukai Medical Center, Fukuoka, Japan.
authors: Nobuhiro
authors: N
authors: Kodama
authors: Department of Pharmacy, Fukuoka Tokushukai Medical Center, Kasuga, Japan.
authors: Daiki
authors: D
authors: Yamashita
authors: Department of Pharmacy, Fukuoka Tokushukai Medical Center, Kasuga, Japan.
authors: Hirokazu
authors: H
authors: Tanaka
authors: Department of Pharmacy, Fukuoka Tokushukai Medical Center, Kasuga, Japan.
authors: Sachiko
authors: S
authors: Inoue
authors: Department of Pharmaceutical and Health Care Management, Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka, Japan.
authors: Osamu
authors: O
authors: Imakyure
authors: Department of Pharmacy, Fukuoka Tokushukai Medical Center, Kasuga, Japan.
authors: Masaaki
authors: M
authors: Hirakawa
authors: Department of Pharmaceutical Care and Health Sciences, Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka, Japan.
authors: Hideki
authors: H
authors: Shuto
authors: Department of Pharmaceutical Care and Health Sciences, Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka, Japan.
authors: Yasufumi
authors: Y
authors: Kataoka
mesh_terms: D000368:Aged; D000900:Anti-Bacterial Agents / Q000009:adverse effects*; D063926:Drug Hypersensitivity Syndrome / Q000175:diagnosis* / Q000209:etiology*; D004347:Drug Interactions; D006801:Humans; D008297:Male; D017334:Teicoplanin / Q000009:adverse effects*; D014640:Vancomycin / Q000009:adverse effects*
chemical_list: D000900:Anti-Bacterial Agents; D017334:Teicoplanin; D014640:Vancomycin