title: Heterogeneous incidence and propagation of spreading depolarizations.
abstract: Spreading depolarizations are implicated in a diverse set of neurologic diseases. They are unusual forms of nervous system activity in that they propagate very slowly and approximately concentrically, apparently not respecting the anatomic, synaptic, functional, or vascular architecture of the brain. However, there is evidence that spreading depolarizations are not truly concentric, isotropic, or homogeneous, either in space or in time. Here we present evidence from KCl-induced spreading depolarizations, in mouse and rat, in vivo and in vitro, showing the great variability that these depolarizations can exhibit. This variability can help inform the mechanistic understanding of spreading depolarizations, and it has implications for their phenomenology in neurologic disease.
authors: 1 Department of Neurology, University of Utah, Salt Lake City, UT, USA.
authors: Dan
authors: D
authors: Kaufmann
authors: 1 Department of Neurology, University of Utah, Salt Lake City, UT, USA.|2 Department of Neurology, University of California Los Angeles, Los Angeles, CA, USA.
authors: Jeremy J
authors: JJ
authors: Theriot
authors: 2 Department of Neurology, University of California Los Angeles, Los Angeles, CA, USA.
authors: Jekaterina
authors: J
authors: Zyuzin
authors: 1 Department of Neurology, University of Utah, Salt Lake City, UT, USA.
authors: C Austin
authors: CA
authors: Service
authors: 3 Rehabilitation Medicine Department, Mark O. Hatfield Clinical Research Center, National Institutes of Health, Bethesda, MD, USA.|4 Mathematical Biosciences Institute, The Ohio State University, Columbus, OH, USA.
authors: Joshua C
authors: JC
authors: Chang
authors: 5 Department of Mechanical and Aerospace Engineering, University of California Los Angeles, Los Angeles, CA, USA.
authors: Y Tanye
authors: YT
authors: Tang
authors: 1 Department of Neurology, University of Utah, Salt Lake City, UT, USA.|6 Department of Neurology, University of Liège, Liège, Belgium.
authors: Vladimir B
authors: VB
authors: Bogdanov
authors: 6 Department of Neurology, University of Liège, Liège, Belgium.
authors: Sylvie
authors: S
authors: Multon
authors: 6 Department of Neurology, University of Liège, Liège, Belgium.
authors: Jean
authors: J
authors: Schoenen
authors: 5 Department of Mechanical and Aerospace Engineering, University of California Los Angeles, Los Angeles, CA, USA.
authors: Y Sungtaek
authors: YS
authors: Ju
authors: 1 Department of Neurology, University of Utah, Salt Lake City, UT, USA.|2 Department of Neurology, University of California Los Angeles, Los Angeles, CA, USA.
authors: K C
authors: KC
authors: Brennan
mesh_terms: D000818:Animals; D001921:Brain / Q000098:blood supply / Q000000981:diagnostic imaging / Q000187:drug effects / Q000503:physiopathology*; D013181:Cortical Spreading Depression / Q000187:drug effects*; D006439:Hemodynamics / Q000187:drug effects / Q000502:physiology; D066298:In Vitro Techniques; D008297:Male; D008810:Mice, Inbred C57BL; D008959:Models, Neurological; D061848:Optical Imaging; D011189:Potassium Chloride / Q000494:pharmacology*; D017207:Rats, Sprague-Dawley; D058067:Wavelet Analysis
chemical_list: D011189:Potassium Chloride
keywords: Spreading depolarization; anisotropy; cortical spreading depression; susceptibility; velocity