title: Serum markers of inflammation and oxidative stress in sarcopenia.
abstract: BACKGROUND
  Sarcopenia is a geriatric syndrome characterized by the presence of low muscle mass and function. Possible mechanisms underlying sarcopenia include oxidative stress and elevation of inflammatory cytokines.
  
  
  OBJECTIVE
  The aim of the study was to evaluate the relationship between sarcopenia and biomarkers that may be involved in its pathogenesis and hence early detection.
  
  
  METHODS
  A total of 72 patients (36 sarcopenic and 36 non-sarcopenic) were included in the study. An experienced geriatric team applied comprehensive geriatric assessment to all patients. Anthropometric measures, gait speed and handgrip strength were recorded. Bioelectrical impedance analysis was used to assess skeletal muscle mass. In addition to routine clinical laboratory tests, serum adiponectin, thioredoxin-1 and pentraxin-3 levels were measured. Sarcopenia was defined according to the European Working Group on Sarcopenia in older Adults as the presence of low muscle mass and low muscle function or muscle performance.
  
  
  RESULTS
  Sarcopenic patients were more likely to be functionally dependent and had lower scores on comprehensive geriatric assessment tools. Erythrocyte sedimentation rate (ESR) and C-reactive protein levels were significantly higher in the sarcopenic group. There was no significant difference in serum levels of thioredoxin-1 and pentraxin-3. Sarcopenic patients had lower levels of hemoglobin, albumin, total protein, calcium, triglycerides, uric acid and adiponectin (p < 0.05). Hypertension and body mass index were inversely correlated with sarcopenia whereas ESR was positively correlated.
  
  
  CONCLUSIONS
  The present study demonstrated an association of sarcopenia with inflammatory markers CRP, ESR and adiponectin. Long-term prospective studies are warranted to confirm the relationship between markers oxidative stress and age related muscle decline.
authors: Division of Geriatric Medicine, Department of Internal Medicine, Gazi University Medical School, 06010, Emek, Ankara, Turkey. alpabusra@hotmail.com.
authors: Busra
authors: B
authors: Can
authors: Division of Geriatric Medicine, Department of Internal Medicine, Gazi University Medical School, 06010, Emek, Ankara, Turkey.
authors: Ozgur
authors: O
authors: Kara
authors: Division of Geriatric Medicine, Department of Internal Medicine, Gazi University Medical School, 06010, Emek, Ankara, Turkey.
authors: Muhammet Cemal
authors: MC
authors: Kizilarslanoglu
authors: Division of Geriatric Medicine, Department of Internal Medicine, Gazi University Medical School, 06010, Emek, Ankara, Turkey.
authors: Gunes
authors: G
authors: Arik
authors: Division of Geriatric Medicine, Department of Internal Medicine, Gazi University Medical School, 06010, Emek, Ankara, Turkey.
authors: Gozde Sengul
authors: GS
authors: Aycicek
authors: Division of Geriatric Medicine, Department of Internal Medicine, Gazi University Medical School, 06010, Emek, Ankara, Turkey.
authors: Fatih
authors: F
authors: Sumer
authors: Department of Internal Medicine, Gazi University Medical School, Ankara, Turkey.
authors: Ramazan
authors: R
authors: Civelek
authors: Department of Biochemistry, Gazi University Medical School, Ankara, Turkey.
authors: Canan
authors: C
authors: Demirtas
authors: Division of Geriatric Medicine, Department of Internal Medicine, Gazi University Medical School, 06010, Emek, Ankara, Turkey.
authors: Zekeriya
authors: Z
authors: Ulger
mesh_terms: D052242:Adiponectin / Q000097:blood*; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000032:analysis; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D015577:Geriatric Assessment / Q000379:methods*; D006801:Humans; D008297:Male; D053580:Muscle Strength / Q000502:physiology; D018482:Muscle, Skeletal / Q000473:pathology*; D018384:Oxidative Stress / Q000502:physiology; D011446:Prospective Studies; D055948:Sarcopenia / Q000175:diagnosis* / Q000473:pathology; D000683:Serum Amyloid P-Component; D000099153:Pentraxins
chemical_list: D052242:Adiponectin; D015415:Biomarkers; D002097:C-Reactive Protein; D000683:Serum Amyloid P-Component; D000099153:Pentraxins; C499918:ADIPOQ protein, human
keywords: Adiponectin; Inflammation; Oxidative stress; Pentraxin-3; Sarcopenia; Thioredoxin-1