title: An RGS2 3'UTR polymorphism is associated with preeclampsia in overweight women.
abstract: Preeclampsia is a common and heterogeneous vascular syndrome of pregnancy. Its genetic risk profile is yet unknown and may vary between individuals and populations. The rs4606 3' UTR polymorphism of the Regulator of G-protein signaling 2 gene (RGS2) in the mother has been implicated in preeclampsia as well as in the development of chronic hypertension after preeclampsia. The RGS2 protein acts as an inhibitor of physiological vasoconstrictive pathways, and a low RGS2 level is associated with hypertension and obesity, two conditions that predispose to preeclampsia. We genotyped the rs4606 polymorphism in 1339 preeclamptic patients and in 697 controls from the Finnish Genetics of Preeclampsia Consortium (FINNPEC) cohort to study the association of the variant with preeclampsia.
  
  
  
  No association between rs4606 and preeclampsia was detected in the analysis including all women. However, the polymorphism was associated with preeclampsia in a subgroup of overweight women (body mass index ≥ 25 kg/m(2), and < 30 kg/m(2)) (dominant model; odds ratio, 1.64; 95 % confidence interval, 1.10-2.42).
  
  
  
  Our results suggest that RGS2 might be involved in the pathogenesis of preeclampsia particularly in overweight women and contribute to their increased risk for hypertension and other types of cardiovascular disease later in life.
authors: Medical and Clinical Genetics, University of Helsinki and Helsinki University Hospital, Helsinki, Finland. tiina.karppanen@helsinki.fi.
authors: Tiina
authors: 0000-0002-0954-478X
authors: T
authors: Karppanen
authors: Medical and Clinical Genetics, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
authors: Tea
authors: T
authors: Kaartokallio
authors: Medical and Clinical Genetics, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.|Obstetrics and Gynecology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.|Department of Obstetrics and Gynecology, South-Karelia Central Hospital, Lappeenranta, Finland.
authors: Miira M
authors: MM
authors: Klemetti
authors: Obstetrics and Gynecology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
authors: Seppo
authors: S
authors: Heinonen
authors: Chronic Disease Prevention Unit, National Institute for Health and Welfare, Helsinki, Finland.|Children's Hospital, Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland.|PEDEGO Research Unit, MRC Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland.
authors: Eero
authors: E
authors: Kajantie
authors: Medical and Clinical Genetics, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.|Department of Biosciences and Nutrition, and Science for Life Laboratory, Karolinska Institutet, Stockholm, Sweden.|Folkhälsan Institute of Genetics, Helsinki, Finland.
authors: Juha
authors: J
authors: Kere
authors: Division of Cardiovascular Medicine, University of Cambridge, Cambridge, UK.
authors: Katja
authors: K
authors: Kivinen
authors: PEDEGO Research Unit, MRC Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland.|Department of Government services, National Institute for Health and Welfare, Helsinki, Finland.
authors: Anneli
authors: A
authors: Pouta
authors: Faculty of Medicine, University of Oslo, Oslo, Norway.|Department of Obstetrics and Gynecology, Oslo University Hospital, Oslo, Norway.
authors: Anne Cathrine
authors: AC
authors: Staff
authors: Medical and Clinical Genetics, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.|Obstetrics and Gynecology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.|Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland.
authors: Hannele
authors: H
authors: Laivuori
mesh_terms: D020413:3' Untranslated Regions; D000328:Adult; D000483:Alleles; D015415:Biomarkers; D015992:Body Mass Index; D016022:Case-Control Studies; D005260:Female; D005786:Gene Expression Regulation; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008954:Models, Biological; D016017:Odds Ratio; D050177:Overweight / Q000150:complications* / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D011225:Pre-Eclampsia / Q000175:diagnosis / Q000209:etiology* / Q000378:metabolism; D011247:Pregnancy; D020710:RGS Proteins / Q000235:genetics* / Q000378:metabolism; D012307:Risk Factors
chemical_list: D020413:3' Untranslated Regions; D015415:Biomarkers; D020710:RGS Proteins; C087182:RGS2 protein, human
keywords: Candidate gene study; Preeclampsia; Pregnancy; Regulator of G-protein signaling 2