title: Dynamic transition of neuronal firing induced by abnormal astrocytic glutamate oscillation.
abstract: The gliotransmitter glutamate released from astrocytes can modulate neuronal firing by activating neuronal N-methyl-D-aspartic acid (NMDA) receptors. This enables astrocytic glutamate(AG) to be involved in neuronal physiological and pathological functions. Based on empirical results and classical neuron-glial "tripartite synapse" model, we propose a practical model to describe extracellular AG oscillation, in which the fluctuation of AG depends on the threshold of calcium concentration, and the effect of AG degradation is considered as well. We predict the seizure-like discharges under the dysfunction of AG degradation duration. Consistent with our prediction, the suppression of AG uptake by astrocytic transporters, which operates by modulating the AG degradation process, can account for the emergence of epilepsy.
authors: State Key Laboratory for Strength and Vibration of Mechanical Structures, School of Aerospace, Xi'an Jiaotong University, Xi'an 710049, China.
authors: Jiajia
authors: J
authors: Li
authors: College of Science, China University of Mining and Technology, Xuzhou 221116, China.
authors: Jun
authors: J
authors: Tang
authors: Department of Physics, Lanzhou University of Technology, Lanzhou 730050, China.
authors: Jun
authors: J
authors: Ma
authors: State Key Laboratory for Strength and Vibration of Mechanical Structures, School of Aerospace, Xi'an Jiaotong University, Xi'an 710049, China.
authors: Mengmeng
authors: M
authors: Du
authors: State Key Laboratory for Strength and Vibration of Mechanical Structures, School of Aerospace, Xi'an Jiaotong University, Xi'an 710049, China.
authors: Rong
authors: R
authors: Wang
authors: State Key Laboratory for Strength and Vibration of Mechanical Structures, School of Aerospace, Xi'an Jiaotong University, Xi'an 710049, China.
authors: Ying
authors: Y
authors: Wu
mesh_terms: D001224:Aspartic Acid / Q000378:metabolism; D001253:Astrocytes / Q000378:metabolism / Q000473:pathology; D018698:Glutamic Acid / Q000378:metabolism*; D006624:Hippocampus / Q000378:metabolism / Q000473:pathology; D006801:Humans; D009457:Neuroglia / Q000378:metabolism* / Q000473:pathology; D009474:Neurons / Q000378:metabolism* / Q000473:pathology; D016194:Receptors, N-Methyl-D-Aspartate / Q000235:genetics* / Q000378:metabolism; D012640:Seizures / Q000378:metabolism* / Q000503:physiopathology; D013569:Synapses / Q000378:metabolism / Q000473:pathology
chemical_list: D016194:Receptors, N-Methyl-D-Aspartate; D001224:Aspartic Acid; D018698:Glutamic Acid