title: Pregnancy in fibrodysplasia ossificans progressiva.
abstract: Fibrodysplasia ossificans progressiva (FOP) is a rare disabling genetic disorder characterized by progressive postnatal heterotopic ossification leading to cumulative disability. Heterotopic bone formation in FOP usually begins in early childhood following a series of painful, post-traumatic, inflammatory soft-tissue swellings known as flare-ups, which later undergo ossification resulting in the progressive immobilization of the chest wall, limbs and jaw by early adulthood. Pregnancy in FOP has occurred infrequently and reproductive decisions are a dilemma for an individual or couple with FOP. We present the clinical course, medical management and potential concerns of four cases of pregnancy in FOP.
authors: Department of Obstetrics & Gynaecology, Princess Alexandra Hospital , Harlow, Essex CM20 1QX , UK.
authors: Javaid A
authors: JA
authors: Muglu
authors: Department of Obstetrics & Gynaecology, Hope Hospital , Stott Lane, Salford M6 8HD , UK.
authors: Aditya
authors: A
authors: Garg
authors: Department of Obstetrics & Gynaecology, Rochdale Infirmary, Pennine Acute Hospitals NHS Trust , Rochdale, Lancashire, Manchester OL12 0NB , UK.
authors: T
authors: T
authors: Pandiarajan
authors: Departments of Orthopaedic Surgery and Genetics, The Center for Research in FOP and Related Disorders, The Perelman School of Medicine, The University of Pennsylvania , Philadelphia, PA 19104 , USA.
authors: Eileen M
authors: EM
authors: Shore
authors: Departments of Orthopaedic Surgery and Medicine, The Center for Research in FOP and Related Disorders, The University of Pennsylvania School of Medicine , Philadelphia, PA 19104 , USA.
authors: Frederick S
authors: FS
authors: Kaplan
authors: Department of Obstetrics & Gynaecology, University Hospital Lewisham , Lewisham High Street, London SE13 6LH , UK.
authors: Dhiraj
authors: D
authors: Uchil
authors: Department of Obstetrics & Gynaecology, Rochdale Infirmary, Pennine Acute Hospitals NHS Trust , Rochdale, Lancashire, Manchester OL12 0NB , UK.
authors: Malcolm J
authors: MJ
authors: Dickson
keywords: bone morphogenetic protein; fibrodysplasia ossificans progressiva; heterotopic ossification