title: Structural characterization and anti-cancerous potential of gallium bioactive glass/hydrogel composites.
abstract: A bioactive glass series (0.42SiO2-0.10Na2O-0.08CaO-(0.40-X)ZnO-(X)Ga2O3) was incorporated into carboxymethyl cellulose (CMC)/dextran (Dex) hydrogels in three different amounts (0.05, 0.10, and 0.25m(2)), and the resulting composites were characterized using transmission electron microscopy (TEM), differential scanning calorimetry (DSC), and (13)C Cross Polarization Magic Angle Spinning Nuclear Magnetic Resonance (CP MAS-NMR). Composite extracts were also evaluated in vitro against MG-63 osteosarcoma cells. TEM confirmed glass distribution throughout the composites, although some particle agglomeration was observed. DSC revealed that glass composition and content did have small effects on both Tg and Tm. MAS-NMR revealed that both CMC and Dex were successfully functionalized, that cross-linking occurred, and that glass addition did slightly alter bonding environments. Cell viability analysis suggested that extracts of the glass and composites with the largest Ga-content significantly decreased MG-63 osteosarcoma viability after 30days. This study successfully characterized this composite series, and demonstrated their potential for anti-cancerous applications.
authors: Inamori School of Engineering, Alfred University, Alfred, NY, USA. Electronic address: tjk2@alfred.edu.
authors: T J
authors: TJ
authors: Keenan
authors: Inamori School of Engineering, Alfred University, Alfred, NY, USA.
authors: L M
authors: LM
authors: Placek
authors: Dept. of Bioengineering, The University of Toledo, Toledo, OH, USA.
authors: A
authors: A
authors: Coughlan
authors: Inamori School of Engineering, Alfred University, Alfred, NY, USA; College of Liberal Arts & Sciences, Dept. of Chemistry, Alfred University, Alfred, NY, USA.
authors: G M
authors: GM
authors: Bowers
authors: Inamori School of Engineering, Alfred University, Alfred, NY, USA.
authors: M M
authors: MM
authors: Hall
authors: Inamori School of Engineering, Alfred University, Alfred, NY, USA.
authors: A W
authors: AW
authors: Wren
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology; D001672:Biocompatible Materials / Q000737:chemistry / Q000494:pharmacology; D001859:Bone Neoplasms / Q000188:drug therapy; D002266:Carboxymethylcellulose Sodium / Q000031:analogs & derivatives* / Q000494:pharmacology; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D003911:Dextrans / Q000737:chemistry* / Q000494:pharmacology; D005708:Gallium / Q000737:chemistry* / Q000494:pharmacology; D005898:Glass / Q000737:chemistry*; D006801:Humans; D020100:Hydrogels / Q000737:chemistry* / Q000494:pharmacology; D012516:Osteosarcoma / Q000188:drug therapy
chemical_list: D000970:Antineoplastic Agents; D001672:Biocompatible Materials; D003911:Dextrans; D020100:Hydrogels; D005708:Gallium; D002266:Carboxymethylcellulose Sodium
keywords: Anti-cancerous; Bioactive glass; Characterization; Composites; Hydrogel