title: Protective effect of polysaccharides from Lycium barbarum on spermatogenesis of mice with impaired reproduction system induced by cyclophosphamide.
abstract: Lycium barbarum (L. barbarum) polysaccharides (LBPs) are the main bioactive component. However, effect of LBP on spermatogenesis of mice with impaired reproduction system induced by cyclophosphamide is undetermined.
  
  
  
  This study aims to investigate the effect of LBP on spermatogenesis of rats with impaired reproduction system induced by cyclophosphamide. Kunming mice were randomly divided into five groups as follows: normal control group, model group (treated with cyclophosphamide) and three LBP groups (treated with cyclophosphamide and 0.2, 0.4 and 0.6 g/kg LBPs, respectively).
  
  
  
  Results indicate that LBP treatment improved sperm density, sperm movement, the rate of normal sperm morphology, and protein expression and superoxide dismutase activity in the testes of the mice and decreased the nitrate nitrogen level in the testes of the mice.
  
  
  
  LBPs have obviously protective effect on the spermatogenesis of rats with impaired reproduction system induced by cyclophosphamide.
authors: College of Veterinary Medicine, Gansu Agricultural University, Lanzhou, China.|Department of Clinical Laboratory, The Second People's Hospital of Lianyungang, Xinpu, China.
authors: Li
authors: L
authors: Qian
authors: College of Veterinary Medicine, Gansu Agricultural University, Lanzhou, China. yusjgs@sina.com.
authors: Sijiu
authors: S
authors: Yu
mesh_terms: D000818:Animals; D002478:Cells, Cultured; D003520:Cyclophosphamide / Q000633:toxicity; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000627:therapeutic use*; D007248:Infertility, Male / Q000139:chemically induced / Q000188:drug therapy*; D032305:Lycium / Q000276:immunology; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D051381:Rats; D013081:Sperm Motility / Q000187:drug effects; D013091:Spermatogenesis / Q000187:drug effects; D013094:Spermatozoa / Q000187:drug effects* / Q000473:pathology; D013482:Superoxide Dismutase / Q000378:metabolism*; D013737:Testis / Q000378:metabolism* / Q000473:pathology
chemical_list: D004365:Drugs, Chinese Herbal; C500223:lycium barbarum polysaccharide; D003520:Cyclophosphamide; D013482:Superoxide Dismutase
keywords: 
  Lycium barbarum
  ; polysaccharide; spermatogenesis