title: The synergistic antibacterial activity and mechanism of multicomponent metal ions-containing aqueous solutions against Staphylococcus aureus.
abstract: Silver (Ag+), zinc (Zn2+) and copper (Cu2+) ions, are well known for their broad-spectrum antibacterial activities while generating low resistance. However, whether or multiple metal ions in aqueous solutions acted synergistically or antagonistically antimicrobial properties, remained unknown. Therefore, it was of great significance to investigate the antibacterial properties of multicomponent metal ions-containing aqueous solutions. In this study, the antibacterial activities of multicomponent metal ions-containing aqueous solutions were investigated for the first time. We found that the antibacterial activities of multicomponent metal ions-containing aqueous solutions were higher than those of single metal ion-containing aqueous solution. Furthermore, the synergistic antibacterial mechanism of these multicomponent metal ions-containing aqueous solutions was first investigated. The generation of reactive oxygen species (ROS) through electron transfer in the enzymes and Fenton reactions formed the main synergistic antibacterial mechanism of the multicomponent metal ions-containing aqueous solutions. Therefore, the encouraging results demonstrate the great potential applications of multicomponent metal ions for the design of new biomaterials or prosthesis containing Ag-Cu-Zn alloy which can release Ag+, Zn2+and Cu2+and minimize the risk of hospital acquired infection.
authors: School of Materials Science and Engineering, South China University of Technology, Guangzhou 510641, China; Guangdong Key Lab of Orthopedic Technology and Implant Materials, Key Laboratory of Trauma & Tissue Repair of Tropical Area of PLA, Guangzhou General Hospital of Guangzhou Military Command, Guangzhou 510010, China.
authors: Xiaolan
authors: X
authors: Wang
authors: Second Military Medical University, Shanghai 200433, China; Guangdong Key Lab of Orthopedic Technology and Implant Materials, Key Laboratory of Trauma & Tissue Repair of Tropical Area of PLA, Guangzhou General Hospital of Guangzhou Military Command, Guangzhou 510010, China.
authors: Shaoxiang
authors: S
authors: Liu
authors: Guangdong Key Lab of Orthopedic Technology and Implant Materials, Key Laboratory of Trauma & Tissue Repair of Tropical Area of PLA, Guangzhou General Hospital of Guangzhou Military Command, Guangzhou 510010, China.
authors: Mei
authors: M
authors: Li
authors: School of Materials Science and Engineering, South China University of Technology, Guangzhou 510641, China.
authors: Peng
authors: P
authors: Yu
authors: Guangdong Key Lab of Orthopedic Technology and Implant Materials, Key Laboratory of Trauma & Tissue Repair of Tropical Area of PLA, Guangzhou General Hospital of Guangzhou Military Command, Guangzhou 510010, China.
authors: Xiao
authors: X
authors: Chu
authors: Guangdong Key Lab of Orthopedic Technology and Implant Materials, Key Laboratory of Trauma & Tissue Repair of Tropical Area of PLA, Guangzhou General Hospital of Guangzhou Military Command, Guangzhou 510010, China.
authors: Lihua
authors: L
authors: Li
authors: Institute of Chemical Engineering and Light Industry, Guangdong University of Technology, Guangzhou 510006, China.
authors: Guoxin
authors: G
authors: Tan
authors: School of Materials Science and Engineering, South China University of Technology, Guangzhou 510641, China.
authors: Yingjun
authors: Y
authors: Wang
authors: School of Materials Science and Engineering, South China University of Technology, Guangzhou 510641, China.
authors: Xiaofeng
authors: X
authors: Chen
authors: Guangdong Key Lab of Orthopedic Technology and Implant Materials, Key Laboratory of Trauma & Tissue Repair of Tropical Area of PLA, Guangzhou General Hospital of Guangzhou Military Command, Guangzhou 510010, China. Electronic address: luck_2001@126.com.
authors: Yu
authors: Y
authors: Zhang
authors: School of Materials Science and Engineering, South China University of Technology, Guangzhou 510641, China; Guangdong Key Lab of Biomedical Engineering, South China University of Technology, Guangzhou 510006, China. Electronic address: ning_lab@hotmail.com.
authors: Chengyun
authors: C
authors: Ning
mesh_terms: D000497:Alloys / Q000737:chemistry / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology; D003300:Copper / Q000737:chemistry / Q000494:pharmacology; D017382:Reactive Oxygen Species / Q000378:metabolism; D012834:Silver / Q000737:chemistry / Q000494:pharmacology; D013211:Staphylococcus aureus / Q000378:metabolism*; D015032:Zinc / Q000737:chemistry / Q000494:pharmacology
chemical_list: D000497:Alloys; D000900:Anti-Bacterial Agents; D017382:Reactive Oxygen Species; D012834:Silver; D003300:Copper; D015032:Zinc
keywords: Antibacterial activities; Multicomponent metal ions; Synergistic antibacterial mechanism