title: Solvent Induced Morphological Evolution of Cholesterol Based Glucose Tailored Amphiphiles: Transformation from Vesicles to Nanoribbons.
abstract: Supramolecular self-assembly of low molecular mass amphiphiles is of topical interest with the urge to achieve precise control over the formation of various self-aggregated structures. Particularly, fabrication of multifarious nanostructures from single molecular backbone would be highly advantageous for task specific applications of the self-aggregates. To this end, the present study reports the solvent triggered evolution of hierarchical self-assembled structures of cholesterol based glucose appended amphiphiles and the pathway of structural transition. The amphiphiles formed bilayered vesicles in water and gels in different organic solvents. In DMSO-water solvent mixture, it showed gradual transition in the morphology of self-aggregates from vesicle-to-fiber and intermediate morphologies depending on the solvent compositions. Microscopic and spectroscopic investigations showed that morphological transformation took place through fusion, elongation and twisting of self-aggregates owing to the reorganization of the amphiphiles (H-type to J-type) in varied solvent polarity. Moreover, sheetlike molecular organization originating from hydrogen bonding and solvophobic interaction played a vital role in the formation of nanoribbons that led to the formation of gel fibril network. This study endows a new strategy to develop solvent induced multistructured self-aggregates from a single molecular scaffold, unraveling the route of forming hierarchical self-assembly.
authors: Department of Biological Chemistry, Indian Association for the Cultivation of Science , Jadavpur, Kolkata - 700 032, India.
authors: Deep
authors: D
authors: Mandal
authors: Department of Biological Chemistry, Indian Association for the Cultivation of Science , Jadavpur, Kolkata - 700 032, India.
authors: Soumik
authors: S
authors: Dinda
authors: Department of Biological Chemistry, Indian Association for the Cultivation of Science , Jadavpur, Kolkata - 700 032, India.
authors: Pritam
authors: P
authors: Choudhury
authors: Department of Biological Chemistry, Indian Association for the Cultivation of Science , Jadavpur, Kolkata - 700 032, India.
authors: Prasanta Kumar
authors: PK
authors: Das