title: Arabidopsis immune secretory pathways to powdery mildew fungi.
abstract: Innate immune responses in host plants begin with the recognition of pathogen-specific nonself molecules and terminate with the secretion of immune molecules. In the dicotyledonous model plant, Arabidopsis thaliana, two distinct secretory pathways required for disease resistance to powdery mildew fungi have been identified so far. One is an exocytic pathway consisting of PEN1, SNAP33 and VAMP721/722 SNARE proteins, but the other is an efflux-mediated one composed of PEN2 atypical myrosinase and PEN3 ABC transporter. Based on the conservation of the mechanically same exocytic pathway in the monocotyledonous plant barely, the former is regarded as an ancient secretory pathway, whereas the latter is considered as a newly evolved one in the Brassicaceae family including Arabidopsis. We recently identified synaptotagmin 1 as an additional regulator of these two secretory pathways. With current results, we discuss how these two secretory pathways contribute to Arabidopsis immunity depending on fungal adaptedness to Arabidopsis.
authors: a Department of Biological Sciences , Konkuk University , Seoul , Korea.
authors: Hye Sup
authors: HS
authors: Yun
authors: b ReSEAT Program, Korea Institute of Science and Technology Information , Seoul , Korea.
authors: Bin Goo
authors: BG
authors: Kang
authors: c Department of Molecular Biology , Dankook University , Yongin , Korea.
authors: Chian
authors: C
authors: Kwon
mesh_terms: D018528:ATP-Binding Cassette Transporters / Q000235:genetics / Q000378:metabolism; D017360:Arabidopsis / Q000276:immunology* / Q000378:metabolism / Q000382:microbiology*; D029681:Arabidopsis Proteins / Q000235:genetics / Q000378:metabolism; D001203:Ascomycota / Q000276:immunology* / Q000472:pathogenicity*; D060467:Disease Resistance; D018506:Gene Expression Regulation, Plant / Q000235:genetics / Q000502:physiology; D009699:N-Glycosyl Hydrolases / Q000235:genetics / Q000378:metabolism; D050765:Qa-SNARE Proteins / Q000235:genetics / Q000378:metabolism; D050766:Qb-SNARE Proteins / Q000235:genetics / Q000378:metabolism; D050767:Qc-SNARE Proteins / Q000235:genetics / Q000378:metabolism; D050683:R-SNARE Proteins / Q000235:genetics / Q000378:metabolism; D055571:Secretory Pathway / Q000235:genetics / Q000502:physiology; D050863:Synaptotagmin I / Q000235:genetics / Q000378:metabolism
chemical_list: D018528:ATP-Binding Cassette Transporters; D029681:Arabidopsis Proteins; D009699:N-Glycosyl Hydrolases; D050765:Qa-SNARE Proteins; D050766:Qb-SNARE Proteins; D050767:Qc-SNARE Proteins; D050683:R-SNARE Proteins; D050863:Synaptotagmin I; C510424:PDR8 protein, Arabidopsis; C479425:PEN1 protein, Arabidopsis; C439366:SNAP33 protein, Arabidopsis; C000606467:At2g20990 protein, Arabidopsis; C570049:VAMP721 protein, Arabidopsis; C570050:VAMP722 protein, Arabidopsis; C505663:PEN2 protein, Arabidopsis
keywords: Arabidopsis; Immune secretory pathway; PEN1; PEN2; SYT1