title: Characterization of Alzheimer's Disease and Mild Cognitive Impairment in Older Adults in Panama.
abstract: Research on age-related cognitive impairment is scarce in Central America. We report factors associated with cognitive impairment among a sample of older adults in Panama diagnosed with Alzheimer's disease (AD, n = 31), mild cognitive impairment (MCI, n = 43), or no cognitive impairment (controls, n = 185). Apolipoprotein E (ApoE) genotype was assessed in a subset of cases (n = 135). Age (OR = 2.53, 95% CI = 1.03-6.17) and ApoE ɛ4 (OR = 5.14, 95% CI = 2.11-12.52) were significantly related to cognitive impairment (AD/MCI combined). Results underscore the potential of genetic screening in Panama for identifying those at risk of dementia.
authors: Centro de Neurociencias y Unidad de Investigación Clínica, Instituto de Investigaciones Científicas y Servicios de Alta Tecnología (INDICASAT AIP), Ciudad del Saber, Clayton, Apartado Postal 0843-01103, Panamá.|Department of Biotechnology, Acharya Nagarjuna University, Guntur 522 510, India.
authors: Alcibiades E
authors: AE
authors: Villarreal
authors: Centro de Neurociencias y Unidad de Investigación Clínica, Instituto de Investigaciones Científicas y Servicios de Alta Tecnología (INDICASAT AIP), Ciudad del Saber, Clayton, Apartado Postal 0843-01103, Panamá.
authors: Shantal
authors: S
authors: Grajales
authors: Institute for Healthy Aging, University of North Texas Health Science Center, 3500 Camp Bowie Blvd, Fort Worth, TX, 76107, USA.
authors: Sid E
authors: SE
authors: O'Bryant
authors: Department of Psychology, University of North Texas, 1155 Union Circle, Denton, TX, 76203, USA.
authors: Melissa
authors: M
authors: Edwards
authors: Department of Hematology, Social Security Hospital, Calle José de Fábrega, Vía Simón Bolivar, Panamá.
authors: Lineth
authors: L
authors: López
authors: Department of Psychiatry, Social Security Hospital, Calle José de Fábrega, Vía Simón Bolivar, Panamá.
authors: Astevia
authors: A
authors: Montalván
authors: Centro de Neurociencias y Unidad de Investigación Clínica, Instituto de Investigaciones Científicas y Servicios de Alta Tecnología (INDICASAT AIP), Ciudad del Saber, Clayton, Apartado Postal 0843-01103, Panamá.
authors: Gabrielle B
authors: GB
authors: Britton
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000235:genetics* / Q000523:psychology; D000544:Alzheimer Disease / Q000175:diagnosis* / Q000453:epidemiology / Q000235:genetics*; D053327:Apolipoprotein E4 / Q000235:genetics*; D060825:Cognitive Dysfunction / Q000175:diagnosis* / Q000453:epidemiology / Q000235:genetics*; D005260:Female; D006801:Humans; D008297:Male; D009483:Neuropsychological Tests; D010176:Panama / Q000453:epidemiology
chemical_list: D053327:Apolipoprotein E4
keywords: Aging; Alzheimer’s disease; Latin America; apolipoprotein E; cognition; dementia; mild cognitive impairment