title: Melanosomes foster a tumour niche by activating CAFs.
abstract: Extracellular vesicles, such as exosomes, are important effectors in the formation of tumour-fostering niches. Pigmented melanosomes are now shown to have a relevant role in establishing a tumour niche in primary melanoma by reprogramming dermal fibroblasts into cancer-associated fibroblasts through the transfer of miR-211.
authors: Microenvironment and Metastasis Group, Molecular Oncology Program, Spanish National Cancer Research Centre (CNIO), 28029 Madrid, Spain.
authors: Susana
authors: S
authors: García-Silva
authors: Microenvironment and Metastasis Group, Molecular Oncology Program, Spanish National Cancer Research Centre (CNIO), 28029 Madrid, Spain.|Department of Pediatrics, Drukier Institute for Children's Health and Meyer Cancer Center, Weill Cornell Medical College, New York, 10021 New York, USA.
authors: Héctor
authors: H
authors: Peinado
mesh_terms: D000818:Animals; D055354:Exosomes / Q000378:metabolism*; D005347:Fibroblasts / Q000473:pathology; D006801:Humans; D020460:Melanosomes / Q000378:metabolism*; D009362:Neoplasm Metastasis / Q000473:pathology; D009369:Neoplasms / Q000378:metabolism* / Q000473:pathology; D059016:Tumor Microenvironment / Q000502:physiology*