title: Impact of metronomic neoadjuvant chemotherapy on early tongue cancer.
abstract: A metronomic schedule of chemotherapy (resulting in a greater frequency of drug delivery) has shown efficacy in head and neck cancer. Our aim was to investigate the overall survival in tongue cancer patients with metronomic neoadjuvant chemotherapy with bleomycin compared to those with surgery alone.
  
  
  
  In this retrospective study, 117 patients with stages I-II tongue cancer, who had undergone surgery, were divided into the "surgery group" or "metronomic neoadjuvant chemotherapy with bleomycin (15 mg × 6) group." The rate of overall survival was the primary outcome measure; the secondary outcome measures included the rates of distant metastasis, regional recurrence, and local recurrence.
  
  
  
  Of these patients, 54 underwent surgery alone and 63 received neoadjuvant chemotherapy. Neoadjuvant chemotherapy increased overall survival (76 vs. 90 %, P = 0.039). The neoadjuvant chemotherapy group had a significantly lower rates of distant metastasis (0 vs. 13 %, P = 0.003). There was no chemotherapy-related death.
  
  
  
  Metronomic neoadjuvant chemotherapy decreased the rates of distant metastasis and increased the overall survival of tongue tumor patients.
authors: Department of Oral and Maxillofacial Functional Rehabilitation, Graduate School of Medicine, University of the Ryukyus, 207 Uehara, Nishihara, Okinawa, 903-0215, Japan. kinashin@hotmail.com.
authors: Shinichiro
authors: S
authors: Kina
authors: Department of Oral and Maxillofacial Surgery, University Hospital of the Ryukyus, 207 Uehara, Nishihara, Okinawa, Japan.
authors: Toshiyuki
authors: T
authors: Nakasone
authors: Division of Morphological Pathology, Department of Basic Laboratory Sciences, School of Health Sciences, University of the Ryukyus, 207 Uehara, Nishihara, Okinawa, Japan.
authors: Takao
authors: T
authors: Kinjo
authors: Department of Oral and Maxillofacial Functional Rehabilitation, Graduate School of Medicine, University of the Ryukyus, 207 Uehara, Nishihara, Okinawa, 903-0215, Japan.
authors: Tessho
authors: T
authors: Maruyama
authors: Department of Oral and Maxillofacial Surgery, University Hospital of the Ryukyus, 207 Uehara, Nishihara, Okinawa, Japan.
authors: Toshihiro
authors: T
authors: Kawano
authors: Department of Oral and Maxillofacial Functional Rehabilitation, Graduate School of Medicine, University of the Ryukyus, 207 Uehara, Nishihara, Okinawa, 903-0215, Japan.|Department of Oral and Maxillofacial Surgery, University Hospital of the Ryukyus, 207 Uehara, Nishihara, Okinawa, Japan.
authors: Akira
authors: A
authors: Arasaki
mesh_terms: D059250:Administration, Metronomic; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage* / Q000009:adverse effects / Q000627:therapeutic use*; D001761:Bleomycin / Q000008:administration & dosage* / Q000009:adverse effects / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D020360:Neoadjuvant Therapy / Q000009:adverse effects / Q000379:methods*; D009362:Neoplasm Metastasis; D009364:Neoplasm Recurrence, Local / Q000453:epidemiology; D012189:Retrospective Studies; D016019:Survival Analysis; D014062:Tongue Neoplasms / Q000188:drug therapy* / Q000601:surgery; D055815:Young Adult
chemical_list: D000903:Antibiotics, Antineoplastic; D001761:Bleomycin
keywords: Chemotherapy; Distant metastasis; Metronomic; Neoadjuvant; Tongue cancer