title: Sulforaphane prevents quinolinic acid-induced mitochondrial dysfunction in rat striatum.
abstract: Quinolinic acid (QA) triggers striatal neuronal death by an excitotoxic cascade that involves oxidative stress, which in turns is tightly linked to mitochondria. Mitochondrial dysfunction is a molecular feature described in several brain pathologies. In this work, we determined whether the sulforaphane-neuroprotective effect in the rodent experimental model of Huntington's disease induced by QA is associated with mitochondrial function preservation. We found that QA impaired mitochondrial function within 24 h post-lesion. Sulforaphane effectively disrupted the mitochondrial dysfunction by preventing the decrease in respiratory control ratio, transmembrane potential, ability to synthetize ATP, and the activity of mitochondrial complexes I, II, and IV.
authors: Laboratorio de Neurobiología Molecular y Celular, Instituto Nacional de Neurología y Neurocirugía, Deleg. Tlalpan, CP 14269, Ciudad de México, México.|Departamento de Biología, Facultad de Química, Cd. Universitaria, Deleg. Coyoacán, CP 04510, Ciudad de México, México.
authors: Erika Rubí
authors: ER
authors: Luis-García
authors: Departamento de Biología, Facultad de Química, Cd. Universitaria, Deleg. Coyoacán, CP 04510, Ciudad de México, México.
authors: Jorge Humberto
authors: JH
authors: Limón-Pacheco
authors: Laboratorio de Neurobiología Molecular y Celular, Instituto Nacional de Neurología y Neurocirugía, Deleg. Tlalpan, CP 14269, Ciudad de México, México.
authors: Norma
authors: N
authors: Serrano-García
authors: Laboratorio de Microscopía Electrónica, Instituto Nacional de Rehabilitación, Deleg. Tlalpan, CP 14389, Ciudad de México, México.
authors: Alma Delia
authors: AD
authors: Hernández-Pérez
authors: Departamento de Biología, Facultad de Química, Cd. Universitaria, Deleg. Coyoacán, CP 04510, Ciudad de México, México.
authors: José
authors: J
authors: Pedraza-Chaverri
authors: Laboratorio de Neurobiología Molecular y Celular, Instituto Nacional de Neurología y Neurocirugía, Deleg. Tlalpan, CP 14269, Ciudad de México, México.
authors: Marisol
authors: M
authors: Orozco-Ibarra
mesh_terms: D000255:Adenosine Triphosphate / Q000096:biosynthesis; D000818:Animals; D003342:Corpus Striatum / Q000187:drug effects*; D017879:Isothiocyanates / Q000633:toxicity*; D008297:Male; D053078:Membrane Potential, Mitochondrial / Q000187:drug effects; D008928:Mitochondria / Q000187:drug effects*; D017378:Quinolinic Acid / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D013454:Sulfoxides
chemical_list: D017879:Isothiocyanates; D013454:Sulfoxides; D000255:Adenosine Triphosphate; D017378:Quinolinic Acid; C016766:sulforaphane
keywords: Antioxidant; Huntington's disease; electron transport chain; neurodegeneration; neurotoxicity