title: Effect of image-guided hypofractionated stereotactic radiotherapy on peripheral non-small-cell lung cancer.
abstract: The objective of this study was to compare the effects of image-guided hypofractionated radiotherapy and conventional fractionated radiotherapy on non-small-cell lung cancer (NSCLC). Fifty stage- and age-matched cases with NSCLC were randomly divided into two groups (A and B). There were 23 cases in group A and 27 cases in group B. Image-guided radiotherapy (IGRT) and stereotactic radiotherapy were conjugately applied to the patients in group A. Group A patients underwent hypofractionated radiotherapy (6-8 Gy/time) three times per week, with a total dose of 64-66 Gy; group B received conventional fractionated radiotherapy, with a total dose of 68-70 Gy five times per week. In group A, 1-year and 2-year local failure survival rate and 1-year local failure-free survival rate were significantly higher than in group B (P<0.05). The local failure rate (P<0.05) and distant metastasis rate (P>0.05) were lower in group A than in group B. The overall survival rate of group A was significantly higher than that of group B (P=0.03), and the survival rate at 1 year was 87% vs 63%, (P<0.05). The median survival time of group A was longer than that of group B. There was no significant difference in the incidence of complications between the two groups (P>0.05). Compared with conventional fractionated radiation therapy, image-guided hypofractionated stereotactic radiotherapy in NSCLC received better treatment efficacy and showed good tolerability.
authors: Department of Radiotherapy, First Affiliated Hospital of Xian Jiaotong University.
authors: Shu-Wen
authors: SW
authors: Wang
authors: Department of Radiotherapy, First Affiliated Hospital of Xian Jiaotong University.
authors: Juan
authors: J
authors: Ren
authors: Medical School of Xian Jiaotong University, Xi'an, Shaanxi, People's Republic of China.
authors: Yan-Li
authors: YL
authors: Yan
authors: Medical School of Xian Jiaotong University, Xi'an, Shaanxi, People's Republic of China.
authors: Chao-Fan
authors: CF
authors: Xue
authors: Medical School of Xian Jiaotong University, Xi'an, Shaanxi, People's Republic of China.
authors: Li
authors: L
authors: Tan
authors: Medical School of Xian Jiaotong University, Xi'an, Shaanxi, People's Republic of China.
authors: Xiao-Wei
authors: XW
authors: Ma
keywords: hypofractionated radiotherapy; image-guided radiation therapy technology; intensity-modulated radiotherapy; non-small-cell lung cancer; segmentation; stereotactic radiotherapy