title: Regulatory Role of Circular RNAs and Neurological Disorders.
abstract: Circular RNAs (circRNAs) are a class of long noncoding RNAs that are characterized by the presence of covalently linked ends and have been found in all life kingdoms. Exciting studies in regulatory roles of circRNAs are emerging. Here, we summarize classification, characteristics, biogenesis, and regulatory functions of circRNAs. CircRNAs are found to be preferentially expressed along neural genes and in neural tissues. We thus highlight the association of circRNA dysregulation with neurodegenerative diseases such as Alzheimer's disease. Investigation of regulatory role of circRNAs will shed novel light in gene expression mechanisms during development and under disease conditions and may identify circRNAs as new biomarkers for aging and neurodegenerative disorders.
authors: Shanghai Jiao Tong University, Shanghai, 200240, China. gabriflo81@yahoo.it.
authors: Gabriele
authors: G
authors: Floris
authors: Huaqiao University, Quanzhou, 362021, China.
authors: Longbin
authors: L
authors: Zhang
authors: Department of Life and Environmental Sciences, University of Cagliari, Cagliari, Italy.
authors: Paolo
authors: P
authors: Follesa
authors: Department of Cell and Developmental Biology, Cornell University Weill Medical College, 1300 York Avenue, Box 60, New York, NY, 10065, USA. tas2009@med.cornell.edu.
authors: Tao
authors: T
authors: Sun
mesh_terms: D000544:Alzheimer Disease / Q000235:genetics*; D000818:Animals; D015415:Biomarkers / Q000032:analysis; D015870:Gene Expression / Q000235:genetics*; D006801:Humans; D009422:Nervous System Diseases / Q000235:genetics; D012313:RNA / Q000235:genetics*; D000079962:RNA, Circular; D062085:RNA, Long Noncoding / Q000235:genetics*
chemical_list: D015415:Biomarkers; D000079962:RNA, Circular; D062085:RNA, Long Noncoding; D012313:RNA
keywords: Back-splicing; Circular RNA; Neurodegeneration; Regulatory RNA; microRNA sponge