title: The metabolic fate of acetate in cancer.
abstract: Recent high-profile reports have reignited an interest in acetate metabolism in cancer. Acetyl-CoA synthetases that catalyse the conversion of acetate to acetyl-CoA have now been implicated in the growth of hepatocellular carcinoma, glioblastoma, breast cancer and prostate cancer. In this Review, we discuss how acetate functions as a nutritional source for tumours and as a regulator of cancer cell stress, and how preventing its (re)capture by cancer cells may provide an opportunity for therapeutic intervention.
authors: Cancer Metabolism Research Unit, Cancer Research UK Beatson Institute, Switchback Road, Glasgow G61 1BD, Scotland, UK.|Wistar Institute, 3601 Spruce Street, Philadelphia, Pennsylvania 19104, USA.
authors: Zachary T
authors: ZT
authors: Schug
authors: Cancer Metabolism Research Unit, Cancer Research UK Beatson Institute, Switchback Road, Glasgow G61 1BD, Scotland, UK.
authors: Johan
authors: J
authors: Vande Voorde
authors: Cancer Metabolism Research Unit, Cancer Research UK Beatson Institute, Switchback Road, Glasgow G61 1BD, Scotland, UK.
authors: Eyal
authors: E
authors: Gottlieb
mesh_terms: D000085:Acetates / Q000378:metabolism*; D000105:Acetyl Coenzyme A / Q000378:metabolism*; D000069196:Gastrointestinal Microbiome / Q000502:physiology; D006801:Humans; D053858:Metabolic Networks and Pathways; D009369:Neoplasms / Q000378:metabolism* / Q000473:pathology; D015398:Signal Transduction
chemical_list: D000085:Acetates; D000105:Acetyl Coenzyme A