title: miRNA: A Novel Link Between Rice Ragged Stunt Virus and Oryza sativa.
abstract: Rice ragged stunt disease caused leads to severe loss of rice yield. Recently, rice ragged stunt virus (RRSV) were found to be increasingly common in rice-growing regions of China and Vietnam. RRSV may cause problem by interacting with microRNAs (miRNAs) of host cells and the mechanism is not clear yet. In this study we identified 11 miRNAs in response to RRSV infection and predicted their possible targets to viral RNA segments (S1-S10) through the bioinformatics analysis. Interestingly, we found that Osa-miR-168b might bind to both the CDS region and 3'UTR of S5 and S8 and target eEF-1A to inhibit the activity of host cells to facilitate RRSV replication. These results suggest that miRNAs may be a potential target for developing rice against RRSV infection.
authors: Pathogenic Organism and Infectious Diseases Research Institute, School of Basic Medical Sciences, Wuhan University, Donghu Road No. 185, Wuchang, Wuhan, 430071 China ; Guizhou Medcial University, Guiyang, 550004 China.
authors: Yingying
authors: Y
authors: Zhang
authors: Pathogenic Organism and Infectious Diseases Research Institute, School of Basic Medical Sciences, Wuhan University, Donghu Road No. 185, Wuchang, Wuhan, 430071 China ; Guizhou Medcial University, Guiyang, 550004 China.
authors: Xiong
authors: X
authors: Chen
authors: State Key Laboratory of Hybrid Rice and College of Life Sciences, Wuhan University, Wuhan, 430072 China.
authors: Fang
authors: F
authors: Yang
authors: State Key Laboratory of Hybrid Rice and College of Life Sciences, Wuhan University, Wuhan, 430072 China.
authors: Lei
authors: L
authors: Zhang
authors: Pathogenic Organism and Infectious Diseases Research Institute, School of Basic Medical Sciences, Wuhan University, Donghu Road No. 185, Wuchang, Wuhan, 430071 China ; State Key Laboratory of Hybrid Rice and College of Life Sciences, Wuhan University, Wuhan, 430072 China ; Hubei Province Key Laboratory of Allergy and Immunology, Wuhan, 430071 China.
authors: Wanhong
authors: W
authors: Liu
keywords: Oryza sativa; Rice ragged stunt virus; miRNA