title: Enantioselective addition of diphenyl phosphonate to ketimines derived from isatins catalyzed by binaphthyl-modified organocatalysts.
abstract: Chiral binaphthyl-modified squaramide-catalyzed enantioselective addition of diphenyl phosphonate to ketimines derived from isatins has been achieved. This method affords practical and efficient access to chiral 3-amino-3-phosphonyl-substituted oxindole derivatives in high yields with excellent enantioselectivities (up to 99% ee).
authors: Department of Chemistry, Soonchunhyang University, Soonchunhyang-Ro 22, Asan, Chungnam 31538, Korea.
authors: Hee Seung
authors: HS
authors: Jang
authors: Department of Chemistry, Soonchunhyang University, Soonchunhyang-Ro 22, Asan, Chungnam 31538, Korea.
authors: Yubin
authors: Y
authors: Kim
authors: Department of Chemistry, Soonchunhyang University, Soonchunhyang-Ro 22, Asan, Chungnam 31538, Korea.
authors: Dae Young
authors: DY
authors: Kim
keywords: 3-amino-3-phosphonyl-substituted oxindole; bifunctional organocatalyst; ketimines; organocatalysis; squaramide; α-aminophosphonates