title: Neural control of inflammation by the greater splanchnic nerves.
abstract: The brain influences immune function through a powerful neural reflex that suppresses the release of a key pro-inflammatory cytokine, tumor necrosis factor α, after immune challenge. The efferent motor pathway of this reflex is in the splanchnic nerves, not the vagi. This reflex regulates inflammation but does not suppress fever.
authors: Florey Institute of Neuroscience and Mental Health; University of Melbourne; Parkville, Australia; Department of Biomedical and Neuromotor Science; University of Bologna; Bologna, Italy.
authors: Davide
authors: D
authors: Martelli
authors: Florey Institute of Neuroscience and Mental Health; University of Melbourne; Parkville, Australia.
authors: Song T
authors: ST
authors: Yao
authors: Florey Institute of Neuroscience and Mental Health; University of Melbourne; Parkville, Australia; Department of Physiology; University of Melbourne; Parkville, Australia.
authors: Michael J
authors: MJ
authors: McKinley
authors: Florey Institute of Neuroscience and Mental Health; University of Melbourne; Parkville, Australia; Department of Anatomy and Neuroscience; University of Melbourne; Parkville, Australia.
authors: Robin M
authors: RM
authors: McAllen
keywords: endotoxemia; fever; greater splanchnic nerve; inflammation; lipopolysaccharide (LPS); sympathetic nervous system; tumor necrosis factor α (TNFα); vagus nerve