title: Cognitive decline: A vitamin B perspective.
abstract: Cognitive decline is one of the major causes of disability in older people. A high level of homocysteine, a byproduct of vitamin B, has been linked to brain atrophy, which itself is a precursor to cognitive decline leading to dementia and Alzheimer's disease. In addition, a low level of vitamin B is often noted in patients with dementia and Alzheimer's disease and its supplementation has been shown to improve memory and to slow the progress of brain atrophy. This information may aid in the use of vitamin B as a preventative measure against severe cognitive decline, and thus reduce the onset of conditions such as dementia and Alzheimer's disease.
authors: Centre for Chronic Disease, College of Health and Biomedicine, Victoria University, P.O. Box 14426, Melbourne VIC 8001, Australia.
authors: Kathleen
authors: K
authors: Mikkelsen
authors: Centre for Chronic Disease, College of Health and Biomedicine, Victoria University, P.O. Box 14426, Melbourne VIC 8001, Australia.
authors: Lily
authors: L
authors: Stojanovska
authors: Centre for Chronic Disease, College of Health and Biomedicine, Victoria University, P.O. Box 14426, Melbourne VIC 8001, Australia.
authors: Kathy
authors: K
authors: Tangalakis
authors: University Cardiology Clinic, Medical School, Skopje, Macedonia.
authors: Marijan
authors: M
authors: Bosevski
authors: Centre for Chronic Disease, College of Health and Biomedicine, Victoria University, P.O. Box 14426, Melbourne VIC 8001, Australia. Electronic address: vasso.apostolopoulos@vu.edu.au.
authors: Vasso
authors: V
authors: Apostolopoulos
mesh_terms: D003071:Cognition / Q000187:drug effects; D003072:Cognition Disorders / Q000097:blood*; D060825:Cognitive Dysfunction / Q000097:blood*; D019587:Dietary Supplements; D006710:Homocysteine / Q000097:blood*; D006801:Humans; D008568:Memory / Q000187:drug effects; D014803:Vitamin B Complex / Q000008:administration & dosage / Q000097:blood*
chemical_list: D006710:Homocysteine; D014803:Vitamin B Complex
keywords: Ageing; Gerontology; Immune cells; Immune system; Inflammation